PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 2518726-9 1989 Transient expression of HC11 cDNA results in a readily detectable specific set of protein bands in SDS-PAGE analysis of supernatants from radio-labeled COS cells, consistent with HC11 encoding a secreted product(s). Sodium Dodecyl Sulfate 99-102 C-C motif chemokine ligand 2 Homo sapiens 24-28 2648385-3 1989 By a combination of Edman degradation and mass spectrometry, it was established that GDCF-2 comprises 76 amino acid residues, commencing at the N terminus with pyroglutamic acid. Pyrrolidonecarboxylic Acid 160-177 C-C motif chemokine ligand 2 Homo sapiens 85-91 9991992-0 1989 Magnetic susceptibility of stage-2 CocNi1-cCl2 graphite intercalation compounds. Graphite 47-55 C-C motif chemokine ligand 2 Homo sapiens 42-46 3612322-1 1987 Trichloroethylene (CHCL = CCL2) is a colorless aliphatic organic solvent with both historical use in medicine as an anesthetic agent and current use in industry as a degreasing agent. Trichloroethylene 0-17 C-C motif chemokine ligand 2 Homo sapiens 26-30 3415979-4 1988 On analytical sodium dodecyl sulfate-polyacrylamide gel electrophoresis, SMC-CF migrated as a monomeric protein with an apparent molecular weight of 14,500. Sodium Dodecyl Sulfate 14-36 C-C motif chemokine ligand 2 Homo sapiens 73-79 3415979-4 1988 On analytical sodium dodecyl sulfate-polyacrylamide gel electrophoresis, SMC-CF migrated as a monomeric protein with an apparent molecular weight of 14,500. polyacrylamide 37-51 C-C motif chemokine ligand 2 Homo sapiens 73-79 2897326-0 1988 Characterization of a CD11c-reactive monoclonal antibody (HC1/1) obtained by immunizing with phorbol ester differentiated U937 cells. Phorbol Esters 93-106 C-C motif chemokine ligand 2 Homo sapiens 58-63 2897326-1 1988 A mouse monoclonal antibody (HC1/1) specific for a differentiation marker of human monocytes and granulocytes has been generated by using as immunogen the monocytic cell line U937 differentiated with phorbol esters. Phorbol Esters 200-214 C-C motif chemokine ligand 2 Homo sapiens 29-34 7248966-7 1981 Concanavalin A:Sepharose chromatography of the alpha subunit secreted by HeLa CCL 2.2 and CCL 2.1 indicated that both proteins possess oligosaccharide side chains containing mannose while chromatography of these proteins on ricin:agarose suggested that less of the alpha subunit from CCL 2.1 contains galactose than that from CCL 2.2. Sepharose 15-24 C-C motif chemokine ligand 2 Homo sapiens 78-83 7248966-7 1981 Concanavalin A:Sepharose chromatography of the alpha subunit secreted by HeLa CCL 2.2 and CCL 2.1 indicated that both proteins possess oligosaccharide side chains containing mannose while chromatography of these proteins on ricin:agarose suggested that less of the alpha subunit from CCL 2.1 contains galactose than that from CCL 2.2. Oligosaccharides 135-150 C-C motif chemokine ligand 2 Homo sapiens 90-95 7248966-7 1981 Concanavalin A:Sepharose chromatography of the alpha subunit secreted by HeLa CCL 2.2 and CCL 2.1 indicated that both proteins possess oligosaccharide side chains containing mannose while chromatography of these proteins on ricin:agarose suggested that less of the alpha subunit from CCL 2.1 contains galactose than that from CCL 2.2. Oligosaccharides 135-150 C-C motif chemokine ligand 2 Homo sapiens 90-95 7248966-7 1981 Concanavalin A:Sepharose chromatography of the alpha subunit secreted by HeLa CCL 2.2 and CCL 2.1 indicated that both proteins possess oligosaccharide side chains containing mannose while chromatography of these proteins on ricin:agarose suggested that less of the alpha subunit from CCL 2.1 contains galactose than that from CCL 2.2. Oligosaccharides 135-150 C-C motif chemokine ligand 2 Homo sapiens 90-95 291942-2 1979 The EtMes doses effective for either cytotoxicity or mutation induction in a line of HeLa S3 cells are about 1/10th those required in the CCL2 HeLa line of the American Type Culture Collection. Ethyl Methanesulfonate 4-9 C-C motif chemokine ligand 2 Homo sapiens 138-142 33894403-7 2021 Furthermore, NP-RLX ameliorated the chronic AAD-induced AI, pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha), chemokines (CCL2, CCL11) and the pro-fibrotic TGF-beta1/IL-1beta axis on AWR and resulting AHR, as well as human myofibroblast-induced collagen gel contraction, to a similar extent as unconjugated RLX. np-rlx 13-19 C-C motif chemokine ligand 2 Homo sapiens 128-132 16591960-7 1971 The identity of CCl(2) and CCl(2) was demonstrated by measurement of the relative intensities and isotopic splittings of stretching vibrations due to the chlorine isotopes. Chlorine 154-162 C-C motif chemokine ligand 2 Homo sapiens 16-22 16591960-7 1971 The identity of CCl(2) and CCl(2) was demonstrated by measurement of the relative intensities and isotopic splittings of stretching vibrations due to the chlorine isotopes. Chlorine 154-162 C-C motif chemokine ligand 2 Homo sapiens 27-33 33982762-3 2021 The results of ELISA and reverse transcription-quantitative PCR revealed that THCA reduced the secretion and mRNA expression levels of interleukin (IL)-6; IL-8; thymus and activation-regulated chemokine; macrophage-derived chemokine; regulated upon activation, normal T cell expressed and secreted; and monocyte chemoattractant protein-1 in TI mixture-stimulated HaCaT cells. thca 78-82 C-C motif chemokine ligand 2 Homo sapiens 303-337 33894403-7 2021 Furthermore, NP-RLX ameliorated the chronic AAD-induced AI, pro-inflammatory cytokines (IL-1beta, IL-6, TNF-alpha), chemokines (CCL2, CCL11) and the pro-fibrotic TGF-beta1/IL-1beta axis on AWR and resulting AHR, as well as human myofibroblast-induced collagen gel contraction, to a similar extent as unconjugated RLX. Relaxin 16-19 C-C motif chemokine ligand 2 Homo sapiens 128-132 33645008-9 2021 RESULTS: The present results showed that the levels of S1PR3 and its ligand, sphingosine 1-phosphate (S1P), were dramatically increased following ICH, which regulated the expression of CCL2 and p38MAPK. sphingosine 1-phosphate 77-100 C-C motif chemokine ligand 2 Homo sapiens 185-189 32712770-4 2021 In contrast, ziram at 10 mumol.L-1 completely inhibited this phagocytic process, the oxidative burst triggered by zymosan and the production of TNF-alpha, IL-1beta, IL-6, and CCL2 triggered by LPS. Ziram 13-18 C-C motif chemokine ligand 2 Homo sapiens 175-179 33645008-9 2021 RESULTS: The present results showed that the levels of S1PR3 and its ligand, sphingosine 1-phosphate (S1P), were dramatically increased following ICH, which regulated the expression of CCL2 and p38MAPK. sphingosine 1-phosphate 55-58 C-C motif chemokine ligand 2 Homo sapiens 185-189 33992179-9 2021 Fluoxetine may potentially reduce pro-inflammatory chemokine/cytokines levels (such as CCL-2, IL-6, and TNF-alpha) in COVID-19 patients. Fluoxetine 0-10 C-C motif chemokine ligand 2 Homo sapiens 87-92 33813846-11 2021 Inhibition of NETs formation with Cl-amidine decreased mRNA expression of proinflammatory cytokines (intercellular adhesion molecule 1 (ICAM-1), interleukin 1 beta (IL-1beta), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor alpha (TNF-alpha)) in cerebral arteries. N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide 34-44 C-C motif chemokine ligand 2 Homo sapiens 176-210 33813846-11 2021 Inhibition of NETs formation with Cl-amidine decreased mRNA expression of proinflammatory cytokines (intercellular adhesion molecule 1 (ICAM-1), interleukin 1 beta (IL-1beta), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor alpha (TNF-alpha)) in cerebral arteries. N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide 34-44 C-C motif chemokine ligand 2 Homo sapiens 212-217 33781652-0 2021 Glycosaminoglycans located on neutrophils and monocytes impact on CXCL8- and CCL2-induced cell migration. Glycosaminoglycans 0-18 C-C motif chemokine ligand 2 Homo sapiens 77-81 33781652-4 2021 Subsequent analysis of CXCL8- and CCL2-induced chemotaxis revealed that leukocyte migration was strongly reduced after eliminating heparan sulfate from the surface of neutrophils and monocytes. Heparitin Sulfate 131-146 C-C motif chemokine ligand 2 Homo sapiens 34-38 33781652-5 2021 In the case of monocytes, an additional dependence of CCL2-induced chemotaxis on chondroitin sulfate was observed. Chondroitin Sulfates 81-100 C-C motif chemokine ligand 2 Homo sapiens 54-58 33417168-12 2021 In addition, PBM could also promote CCL2 secretion by DRG under oxidative stress. pbm 13-16 C-C motif chemokine ligand 2 Homo sapiens 36-40 33417168-15 2021 PBM could promote survival and axonal regeneration of DRG under SCI oxidative stress, increase the secretion level of CCL2 by DRG, and this change can reduce the polarization of macrophages to M1, further indicating that PBM could promote spinal cord injury repair. pbm 0-3 C-C motif chemokine ligand 2 Homo sapiens 118-122 33417168-15 2021 PBM could promote survival and axonal regeneration of DRG under SCI oxidative stress, increase the secretion level of CCL2 by DRG, and this change can reduce the polarization of macrophages to M1, further indicating that PBM could promote spinal cord injury repair. pbm 221-224 C-C motif chemokine ligand 2 Homo sapiens 118-122 33992032-9 2021 In topical blood, the change of inflammatory factors, such as TNF-a, PTX3, CCL2, PGE2, SOD1, and Mb, was lower in CTC and NT groups than in FC group (p < 0.01 and 0.05). nt 122-124 C-C motif chemokine ligand 2 Homo sapiens 75-79 33886273-8 2021 Enzyme-linked immunosorbent assay results show adsorption of MCP-1 on the poly(sodium 4-styrenesulfonate)-coated gold nanoparticle surface, supporting the hypothesis that adsorption of chemoattractants to nanoparticle surfaces interferes with chemotaxis. styrenesulfonic acid polymer 74-105 C-C motif chemokine ligand 2 Homo sapiens 61-66 34020271-5 2021 In this study we demonstrated that Cr(VI) induced the secretion of tumor promoting components of SASP such as IL-6, IL-8, and granulocyte-macrophage colony stimulating factor (GM-CSF) in senescent L-02 hepatocytes, while the levels of the anti-tumor components of SASP such as chemokine (c-x-c motif) ligand-1 (CXCL-1) and monocyte chemoattractant protein-1 (MCP-1) were not altered. chromium hexavalent ion 35-41 C-C motif chemokine ligand 2 Homo sapiens 323-357 34020271-5 2021 In this study we demonstrated that Cr(VI) induced the secretion of tumor promoting components of SASP such as IL-6, IL-8, and granulocyte-macrophage colony stimulating factor (GM-CSF) in senescent L-02 hepatocytes, while the levels of the anti-tumor components of SASP such as chemokine (c-x-c motif) ligand-1 (CXCL-1) and monocyte chemoattractant protein-1 (MCP-1) were not altered. chromium hexavalent ion 35-41 C-C motif chemokine ligand 2 Homo sapiens 359-364 34051328-6 2021 The results showed that ginsenoside CK significantly inhibited the increase of MCP-1 and TNF-alpha induced by the supernatant of hypertrophic adipocytes, promoted the expression of IL-10, inhibited the activation of inflammatory macrophages and increased the expression of anti-inflammatory macrophages. ginsenoside M1 24-38 C-C motif chemokine ligand 2 Homo sapiens 79-84 34030558-0 2021 Nephroprotective effects of febuxostat and/or mirtazapine against gentamicin-induced nephrotoxicity through modulation of ERK 1/2, NF-kappaB and MCP1. Febuxostat 28-38 C-C motif chemokine ligand 2 Homo sapiens 145-149 34030558-0 2021 Nephroprotective effects of febuxostat and/or mirtazapine against gentamicin-induced nephrotoxicity through modulation of ERK 1/2, NF-kappaB and MCP1. Mirtazapine 46-57 C-C motif chemokine ligand 2 Homo sapiens 145-149 34030558-6 2021 RESULTS: Febuxostat and mirtazapine significantly (p<0.05) alleviated biochemical and histopathological alterations that were induced by gentamicin and for the first time, significantly decreased the renal levels of ERK1/2 and MCP-1. Febuxostat 9-19 C-C motif chemokine ligand 2 Homo sapiens 227-232 34030558-6 2021 RESULTS: Febuxostat and mirtazapine significantly (p<0.05) alleviated biochemical and histopathological alterations that were induced by gentamicin and for the first time, significantly decreased the renal levels of ERK1/2 and MCP-1. Mirtazapine 24-35 C-C motif chemokine ligand 2 Homo sapiens 227-232 34018029-11 2021 Among patients with IRRs, those receiving ibrutinib-obinutuzumab had lower post-obinutuzumab increases in IL-6, IL-8, IL-10, and MCP-1 (P < 0.04) than patients receiving chlorambucil-obinutuzumab. ibrutinib 42-51 C-C motif chemokine ligand 2 Homo sapiens 129-134 33990437-8 2021 PSB reduced postoperative inflammatory response by limiting concentrations of proinflammatory cytokines IL-8, IL-18, IL-23, IL-33 and MCP-1 measured in the first 7-day after surgery (p<0.05). psb 0-3 C-C motif chemokine ligand 2 Homo sapiens 134-139 33946046-10 2021 RESULTS: Firstly, the elevated expressions of LOX-1, MCP-1, and CXCL-1 induced by stimulation with ox-LDL were significantly suppressed by Azilsartan. azilsartan 139-149 C-C motif chemokine ligand 2 Homo sapiens 53-58 33949772-7 2021 Moreover, nintedanib treatment inhibited expression of several cytokines/chemokines, including tumour necrosis factor-alpha, interleukin-1beta and interleukin-6, monocyte chemoattractant protein-1 and prevented infiltration of macrophages to the injured peritoneum. nintedanib 10-20 C-C motif chemokine ligand 2 Homo sapiens 162-196 33275825-8 2021 However, addition of sugammadex up to 180 minutes following LAD2 MRGPRX2 stimulation, significantly reduced CCL2 mRNA and protein induction. Sugammadex 21-31 C-C motif chemokine ligand 2 Homo sapiens 108-112 33275825-11 2021 Interestingly however, sugammadex did impair MRGPRX2-induced CCL2 release, suggesting that it may have some benefit in perhaps dampening less well-defined adverse effects of MRGPRX2-dependent anaphylaxis associated with the more slowly elaborated mast cell mediators. Sugammadex 23-33 C-C motif chemokine ligand 2 Homo sapiens 61-65 33596158-0 2021 l-Cysteine Stimulates the Effect of Vitamin D on Inhibition of Oxidative Stress, IL-8, and MCP-1 Secretion in High Glucose Treated Monocytes. Cysteine 0-10 C-C motif chemokine ligand 2 Homo sapiens 91-96 33747175-10 2021 HSS also reduced the static PA-induced expression of intercellular adhesion molecule-1 and monocyte chemoattractant protein-1. Palmitic Acid 28-30 C-C motif chemokine ligand 2 Homo sapiens 91-125 33596158-0 2021 l-Cysteine Stimulates the Effect of Vitamin D on Inhibition of Oxidative Stress, IL-8, and MCP-1 Secretion in High Glucose Treated Monocytes. Vitamin D 36-45 C-C motif chemokine ligand 2 Homo sapiens 91-96 33596158-3 2021 This study examined the hypothesis that supplementation with vitamin D, in combination with l-cysteine (LC), is better at reducing oxidative stress and thereby, more effective, at inhibiting the secretion of the pro-inflammatory cytokines, Interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in U937 monocytes exposed to high glucose concentrations. Vitamin D 61-70 C-C motif chemokine ligand 2 Homo sapiens 265-299 33596158-3 2021 This study examined the hypothesis that supplementation with vitamin D, in combination with l-cysteine (LC), is better at reducing oxidative stress and thereby, more effective, at inhibiting the secretion of the pro-inflammatory cytokines, Interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in U937 monocytes exposed to high glucose concentrations. Vitamin D 61-70 C-C motif chemokine ligand 2 Homo sapiens 301-306 33596158-3 2021 This study examined the hypothesis that supplementation with vitamin D, in combination with l-cysteine (LC), is better at reducing oxidative stress and thereby, more effective, at inhibiting the secretion of the pro-inflammatory cytokines, Interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in U937 monocytes exposed to high glucose concentrations. Cysteine 104-106 C-C motif chemokine ligand 2 Homo sapiens 265-299 33596158-3 2021 This study examined the hypothesis that supplementation with vitamin D, in combination with l-cysteine (LC), is better at reducing oxidative stress and thereby, more effective, at inhibiting the secretion of the pro-inflammatory cytokines, Interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in U937 monocytes exposed to high glucose concentrations. Cysteine 104-106 C-C motif chemokine ligand 2 Homo sapiens 301-306 33656516-0 2021 Serum Monocyte-Chemoattractant Protein-1 Could Be an Indicator of Coronary Artery Calcium Score. Calcium 82-89 C-C motif chemokine ligand 2 Homo sapiens 6-40 33656517-0 2021 Serum Monocyte-Chemoattractant Protein-1 Could be an Indicator of Coronary Artery Calcium Score-Reply. Calcium 82-89 C-C motif chemokine ligand 2 Homo sapiens 6-40 33965175-11 2021 In addition, ruxolitinib inhibits IFNgamma-induced pro-GVHD pathways on MSCs, which includes HLAABC(MHCI), HLADR(MHCII), CX3CL1, and CCL2. ruxolitinib 13-24 C-C motif chemokine ligand 2 Homo sapiens 133-137 33576698-7 2021 ZnO NPs delivered at 1.0 microg/cm2 in the NACIVT system, mimicking occupational exposure, induced significant increases in metabolic activity and release of the cytokines IL-8 and MCP-1, but no differences were observed using traditional exposures. Zinc Oxide 0-3 C-C motif chemokine ligand 2 Homo sapiens 181-186 33576698-7 2021 ZnO NPs delivered at 1.0 microg/cm2 in the NACIVT system, mimicking occupational exposure, induced significant increases in metabolic activity and release of the cytokines IL-8 and MCP-1, but no differences were observed using traditional exposures. nacivt 43-49 C-C motif chemokine ligand 2 Homo sapiens 181-186 33946212-11 2021 Plasma MCP-1 was decreased significantly in the MTN group at 4 weeks. m-Tolunitrile 48-51 C-C motif chemokine ligand 2 Homo sapiens 7-12 33891564-9 2021 CCL2 could activate the cyclooxygenase-2/prostaglandin E2 (COX-2/PGE2) pathway in macrophage via FoxO1 in a p38 MAPK-dependent manner. Dinoprostone 65-69 C-C motif chemokine ligand 2 Homo sapiens 0-4 33907944-4 2021 In 3 and 6 h after high PTZ dose, the expression of CCL2 and TNF increased in the neocortex. Pentylenetetrazole 24-27 C-C motif chemokine ligand 2 Homo sapiens 52-56 34056329-5 2021 Interestingly, Telmisartan inhibited TNF-alpha-induced expression and secretions of proinflammatory mediators such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and monocyte chemotactic protein 1 (MCP-1). Telmisartan 15-26 C-C motif chemokine ligand 2 Homo sapiens 174-204 34056329-5 2021 Interestingly, Telmisartan inhibited TNF-alpha-induced expression and secretions of proinflammatory mediators such as interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and monocyte chemotactic protein 1 (MCP-1). Telmisartan 15-26 C-C motif chemokine ligand 2 Homo sapiens 206-211 33923651-0 2021 Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 49-54 33959001-11 2021 In MSCs, atorvastatin and aspirin combination reduced the release of pro-inflammatory cytokines such as IL-6, IL-8, MCP-1 and IFN-gamma. Atorvastatin 9-21 C-C motif chemokine ligand 2 Homo sapiens 116-121 33959001-11 2021 In MSCs, atorvastatin and aspirin combination reduced the release of pro-inflammatory cytokines such as IL-6, IL-8, MCP-1 and IFN-gamma. Aspirin 26-33 C-C motif chemokine ligand 2 Homo sapiens 116-121 33959001-12 2021 Atorvastatin alone reduced the release of IL-6, IL-8 and MCP-1 from co-cultures of stroke monocytes and MSCs. Atorvastatin 0-12 C-C motif chemokine ligand 2 Homo sapiens 57-62 33923651-0 2021 Curcumin Inhibits Lysophosphatidic Acid Mediated MCP-1 Expression via Blocking ROCK Signalling. lysophosphatidic acid 18-39 C-C motif chemokine ligand 2 Homo sapiens 49-54 33923651-3 2021 Monocyte chemoattractant protein-1 (MCP-1) is a key inflammatory marker during the development of atherosclerosis, and curcumin blocks MCP-1 expression stimulated by various ligands. Curcumin 119-127 C-C motif chemokine ligand 2 Homo sapiens 135-140 33923651-4 2021 Hence, we studied the action of curcumin on lysophosphatidic acid (LPA) mediated MCP-1 expression and explored the specific underlying mechanisms. Curcumin 32-40 C-C motif chemokine ligand 2 Homo sapiens 81-86 33923651-4 2021 Hence, we studied the action of curcumin on lysophosphatidic acid (LPA) mediated MCP-1 expression and explored the specific underlying mechanisms. lysophosphatidic acid 44-65 C-C motif chemokine ligand 2 Homo sapiens 81-86 33923651-4 2021 Hence, we studied the action of curcumin on lysophosphatidic acid (LPA) mediated MCP-1 expression and explored the specific underlying mechanisms. lysophosphatidic acid 67-70 C-C motif chemokine ligand 2 Homo sapiens 81-86 33923651-6 2021 We found that LPA also signals via the TGFBR1 transactivation pathway to regulate MCP-1 expression. lysophosphatidic acid 14-17 C-C motif chemokine ligand 2 Homo sapiens 82-87 33923651-7 2021 Curcumin blocks LPA mediated TGFBR1 transactivation and subsequent MCP-1 expression by blocking the ROCK signalling. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 67-72 33517251-3 2021 We demonstrate that extracellular cardiolipin induces the secretion of monocyte chemoattractant protein-1 and interferon gamma-induced protein 10 by resting microglia while inhibiting secretion of cytokines by microglia stimulated with lipopolysaccharide, amyloid Abeta42 peptides, or alpha-synuclein. Cardiolipins 34-45 C-C motif chemokine ligand 2 Homo sapiens 71-105 33857535-10 2021 RESULTS: From ten biomarkers, EFA generated four factors reflecting tubule injury/repair (NGAL, IL-18 and YKL-40), tubule injury/fibrosis (KIM-1 and MCP-1), tubule reabsorption (alpha1m and beta2m), and tubule reserve/mineral metabolism (UMOD, FGF23, and PTH). efa 30-33 C-C motif chemokine ligand 2 Homo sapiens 149-154 33850164-5 2021 Cromolyn and a new fluorinated analog dramatically reduced the secretion of a wide spectrum of inflammatory mediators, which included cytokines such as IL-1beta, IL-6, IL-8 and IFN-gamma, and chemokines such as CXCL10, CCL2, CCL3 and CCL4. Cromolyn Sodium 0-8 C-C motif chemokine ligand 2 Homo sapiens 219-223 32924886-7 2021 Neopterin suppresses the expression of monocyte chemotactic protein-1, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in endothelial cells, and thereby suppresses the adhesion of monocytes to endothelial cells. Neopterin 0-9 C-C motif chemokine ligand 2 Homo sapiens 39-69 33839697-5 2021 LCZ696 inhibits LPS-induced expressions and secretions of the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-1alpha (IL-1alpha), and tumor necrosis factor beta (TNF-beta) as well as the chemokines, monocyte chemotactic protein 1 (MCP-1), and chemokine (C-X-C motif) ligand 1 protein (CXCL1). sacubitril and valsartan sodium hydrate drug combination 0-6 C-C motif chemokine ligand 2 Homo sapiens 213-243 33839697-5 2021 LCZ696 inhibits LPS-induced expressions and secretions of the pro-inflammatory cytokines, interleukin-6 (IL-6), interleukin-1alpha (IL-1alpha), and tumor necrosis factor beta (TNF-beta) as well as the chemokines, monocyte chemotactic protein 1 (MCP-1), and chemokine (C-X-C motif) ligand 1 protein (CXCL1). sacubitril and valsartan sodium hydrate drug combination 0-6 C-C motif chemokine ligand 2 Homo sapiens 245-250 34056184-0 2021 Hydroxyl Groups on Annular Ring-B Dictate the Affinities of Flavonol-CCL2 Chemokine Binding Interactions. 3-hydroxyflavone 60-68 C-C motif chemokine ligand 2 Homo sapiens 69-73 33834669-9 2021 Sitagliptin suppressed 5 microg mL-1 of LPS-induced IL-6, IL-8, CCL2, and SOD2 gene expression levels in HGF in a concentration-dependent manner. Sitagliptin Phosphate 0-11 C-C motif chemokine ligand 2 Homo sapiens 64-68 33834669-10 2021 Furthermore, sitagliptin significantly decreased the elevated secretion of IL-6, IL-8, and CCL2 protein induced by LPS. Sitagliptin Phosphate 13-24 C-C motif chemokine ligand 2 Homo sapiens 91-95 33834669-12 2021 Results of qRT-PCR analysis indicated that 0.5 micromol L-1 of sitagliptin and 5 micromol L-1 of BAY11-7082 significantly inhibited LPS-induced IL-6, IL-8, CCL2, and SOD2 gene expressions. Sitagliptin Phosphate 63-74 C-C motif chemokine ligand 2 Homo sapiens 156-160 33834669-12 2021 Results of qRT-PCR analysis indicated that 0.5 micromol L-1 of sitagliptin and 5 micromol L-1 of BAY11-7082 significantly inhibited LPS-induced IL-6, IL-8, CCL2, and SOD2 gene expressions. 3-(4-methylphenylsulfonyl)-2-propenenitrile 97-107 C-C motif chemokine ligand 2 Homo sapiens 156-160 33159802-3 2021 The N-terminal glutamine on immature CCL2 is replaced with pyroglutamate (pE) by glutaminyl cyclase (QC) and isoQC. Glutamine 15-24 C-C motif chemokine ligand 2 Homo sapiens 37-41 33159802-3 2021 The N-terminal glutamine on immature CCL2 is replaced with pyroglutamate (pE) by glutaminyl cyclase (QC) and isoQC. Pyrrolidonecarboxylic Acid 59-72 C-C motif chemokine ligand 2 Homo sapiens 37-41 33159802-3 2021 The N-terminal glutamine on immature CCL2 is replaced with pyroglutamate (pE) by glutaminyl cyclase (QC) and isoQC. Pyrrolidonecarboxylic Acid 74-76 C-C motif chemokine ligand 2 Homo sapiens 37-41 33159802-4 2021 pE-CCL2 is stable and resistant to peptidases. Pyrrolidonecarboxylic Acid 0-2 C-C motif chemokine ligand 2 Homo sapiens 3-7 34012800-9 2021 There are several strategies for TAM targeting and utilizing them for therapeutic purposes including limiting monocyte recruitment and localization through various pathways such as CCL2-CCR2, CSF1-CSF1R, and CXCL12-CXCR4, targeting the activation of TAMs, genetic and epigenetic reprogramming of TAMs to antitumor phenotype, and utilizing TAMs as the carrier for anti-cancer drugs. tam 33-36 C-C motif chemokine ligand 2 Homo sapiens 181-185 33846374-9 2021 DEHP exposure led to a proinflammatory state in SGBS-derived adipocytes (e.g., increased secretion of IL8 and MCP1). Diethylhexyl Phthalate 0-4 C-C motif chemokine ligand 2 Homo sapiens 110-114 33920100-5 2021 Using a solid-phase binding assay, we found that heparan sulfate-bound VEGF-A and CCL2 were displaced by recombinant CHI3L1 in a dose-dependent manner. Heparitin Sulfate 49-64 C-C motif chemokine ligand 2 Homo sapiens 82-86 33639176-7 2021 Baricitinib did modulate other soluble factors besides IFN-gamma, significantly decreasing the spike-specific-response mediated by IL-17, IL-1beta, IL-6, TNF-alpha, IL-4, IL-13, IL-1ra, IL-10, GM-CSF, FGF, IP-10, MCP-1, MIP-1beta (p <= 0.0156). baricitinib 0-11 C-C motif chemokine ligand 2 Homo sapiens 213-218 33189376-7 2021 Likewise, serum Cu was positively associated with HO-1 (beta = 0.0004, P = 0.03) and negatively associated with MCP-1 (beta = -0.0006, P = 0.003) and IL-8 (beta = -0.002, P = 0.03). Copper 16-18 C-C motif chemokine ligand 2 Homo sapiens 112-117 33998893-7 2021 Dex further reduced secreted levels of monocyte chemoattractant protein-1 in addition to suppressing IL-6 and VEGF beyond treatments with CBD. Dexamethasone 0-3 C-C motif chemokine ligand 2 Homo sapiens 39-73 33740174-0 2021 Insulin Rescued MCP-1-Suppressed Cholesterol Efflux to Large HDL2 Particles via ABCA1, ABCG1, SR-BI and PI3K/Akt Activation in Adipocytes. Cholesterol 33-44 C-C motif chemokine ligand 2 Homo sapiens 16-21 33740174-3 2021 In this study, we hypothesize that MCP-1 impairs cholesterol efflux of adipocytes to HDL2 and insulin rescues this process. Cholesterol 49-60 C-C motif chemokine ligand 2 Homo sapiens 35-40 33740174-5 2021 We performed [3H]-cholesterol efflux assay to demonstrate the effect of MCP-1 and insulin on cholesterol efflux from 3T3-L1 adipocytes to large HDL2 particles. Cholesterol 93-104 C-C motif chemokine ligand 2 Homo sapiens 72-77 33683903-3 2021 Notably, highly sulfated-IdoA tetrasaccharide (I-45) exhibited strong binding to CCL2 chemokine thereby blocking CCL2/CCR2-mediated in vitro cancer cell invasion and metastasis. -idoa tetrasaccharide 24-45 C-C motif chemokine ligand 2 Homo sapiens 81-85 33683903-3 2021 Notably, highly sulfated-IdoA tetrasaccharide (I-45) exhibited strong binding to CCL2 chemokine thereby blocking CCL2/CCR2-mediated in vitro cancer cell invasion and metastasis. -idoa tetrasaccharide 24-45 C-C motif chemokine ligand 2 Homo sapiens 113-117 33683903-3 2021 Notably, highly sulfated-IdoA tetrasaccharide (I-45) exhibited strong binding to CCL2 chemokine thereby blocking CCL2/CCR2-mediated in vitro cancer cell invasion and metastasis. i-45 47-51 C-C motif chemokine ligand 2 Homo sapiens 81-85 33683903-3 2021 Notably, highly sulfated-IdoA tetrasaccharide (I-45) exhibited strong binding to CCL2 chemokine thereby blocking CCL2/CCR2-mediated in vitro cancer cell invasion and metastasis. i-45 47-51 C-C motif chemokine ligand 2 Homo sapiens 113-117 33740174-8 2021 In differentiated 3T3-L1 adipocytes, MCP-1 reduced cholesterol efflux to large HDL2 particles by 55.4% via decreasing ATP-binding cassette A1 (ABCA1), ABCG1, and scavenger receptor class B type I (SR-BI) expression. Cholesterol 51-62 C-C motif chemokine ligand 2 Homo sapiens 37-42 33740174-9 2021 Intriguingly, insulin rescued MCP-1 mediated-inhibition of cholesterol efflux to HDL2 in an Akt phosphorylation-dependent manner. Cholesterol 59-70 C-C motif chemokine ligand 2 Homo sapiens 30-35 33740174-12 2021 CONCLUSIONS: These findings indicate that MCP-1 impairs cholesterol efflux to large HDL2 particles in adipocytes, which is reversed by insulin via the upregulation of ABCA1, ABCG1, and SR-BI. Cholesterol 56-67 C-C motif chemokine ligand 2 Homo sapiens 42-47 33998890-7 2021 CBDV (300 nM-10 muM) attenuated levels of monocyte chemoattractant protein (MCP)-1 in HBMECs. cannabidivarin 0-4 C-C motif chemokine ligand 2 Homo sapiens 42-82 34014157-0 2021 Curcumin alleviates inflammation in Takayasu"s arteritis by blocking CCL2 overexpression in adventitial fibroblasts. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 69-73 33655586-9 2021 After high glucose induction, the expression of TNF-alpha, IL-1beta, and IL-6 was increased and the expression of MCP-1, NLPR3, and ASC proteins was also increased (p < .001). Glucose 11-18 C-C motif chemokine ligand 2 Homo sapiens 114-119 34014157-8 2021 RT-qPCR, ELISA and western blot were used to determine the regulatory effect of curcumin on CCL2 expression in aortic adventitia fibroblasts (AAFs) and its mechanism. Curcumin 80-88 C-C motif chemokine ligand 2 Homo sapiens 92-96 34014157-9 2021 RESULTS: Curcumin treatment significantly lowered Kerr score and the levels of serum CCL2 in TAK patients. Curcumin 9-17 C-C motif chemokine ligand 2 Homo sapiens 85-89 34014157-12 2021 After curcumin treatment, the changes in CCL2 were positively associated with the changes in IL-6. Curcumin 6-14 C-C motif chemokine ligand 2 Homo sapiens 41-45 34014157-15 2021 Nevertheless, curcumin could reverse the HSP65-induced CCL2 upregulation through restraining JAK2/AKT/STAT3 pathway. Curcumin 14-22 C-C motif chemokine ligand 2 Homo sapiens 55-59 34014157-17 2021 CONCLUSIONS: Curcumin alleviated inflammation in TAK by downregulating CCL2 overexpression in AAFs through inhibiting the JAK2/AKT/STAT3 signalling pathway. Curcumin 13-21 C-C motif chemokine ligand 2 Homo sapiens 71-75 32317146-5 2021 In this study, we evaluated the effect of the MCP-1 synthesis inhibitor, Bindarit, on primary cultures of fibroblasts from the SSCT of five CTS patients. bindarit 73-81 C-C motif chemokine ligand 2 Homo sapiens 46-51 33405993-8 2021 The concentrations of MCP-1, ISG-15, MX-1, and OAS-1 were observed to be slightly dose-dependent, ranging from 1.0 to 1.8 mg TQ-A3334. tq-a3334 125-133 C-C motif chemokine ligand 2 Homo sapiens 22-27 33880998-11 2021 Further analysis presented that miR-421 overexpression alleviated Mg2+-freeinduced cell injuries by depleting CCL2. magnesium ion 66-70 C-C motif chemokine ligand 2 Homo sapiens 110-114 33205453-8 2021 Furthermore, we found that, after treatment with S100A9, HepG2 and MHCC-97H cells recruited more macrophages via chemokine (C C motif) ligand 2, which suggests a positive feedback between TAMs and HCC cells. tams 188-192 C-C motif chemokine ligand 2 Homo sapiens 113-143 33280267-4 2021 Here we performed high-throughput compound screening (HTS) using this PSC-derived NNS model to find potential therapeutic candidates and identified CUDC-907 as an effective inhibitor of the release of MCP-1 and IP-10. CUDC-907 148-156 C-C motif chemokine ligand 2 Homo sapiens 201-206 33649397-6 2021 Cholesterol loading of M-MO strongly suppressed the high baseline expression of CCL2, whereas in GM-MO the low baseline expression CCL2 remained unchanged during cholesterol loading. Cholesterol 0-11 C-C motif chemokine ligand 2 Homo sapiens 80-84 33599317-13 2022 IL-6 induction was decreased by pretreatment of cells with NF-kappaB inhibitor SN50 or p38 MAPK inhibitor SB203580, while CCL2 induction was reduced by SN50 or JNK inhibitor SP600125. pyrazolanthrone 174-182 C-C motif chemokine ligand 2 Homo sapiens 122-126 33253790-4 2021 Validated by ChIP-qPCR and MassArray methylation analysis, CCL2 expression was inhibited by EZH2-mediated H3K27me3 in the enhancer regions and DNMT1-mediated DNA methylation in the promoter regions, the process of which could be reversed by small-molecular compounds, EPZ011989 and Decitabine. EPZ011989 268-277 C-C motif chemokine ligand 2 Homo sapiens 59-63 33253790-4 2021 Validated by ChIP-qPCR and MassArray methylation analysis, CCL2 expression was inhibited by EZH2-mediated H3K27me3 in the enhancer regions and DNMT1-mediated DNA methylation in the promoter regions, the process of which could be reversed by small-molecular compounds, EPZ011989 and Decitabine. Decitabine 282-292 C-C motif chemokine ligand 2 Homo sapiens 59-63 33253790-6 2021 Furthermore, in an ectopic engraft model of SCLC, disruption of EZH2/DNMT1 function using the combination treatment of EPZ011989 and Decitabine potently abrogated the inhibition of macrophage infiltration and thus suppressed tumor growth, the effect of which was impaired by CCL2 neutralization or macrophage depletion. EPZ011989 119-128 C-C motif chemokine ligand 2 Homo sapiens 275-279 33253790-6 2021 Furthermore, in an ectopic engraft model of SCLC, disruption of EZH2/DNMT1 function using the combination treatment of EPZ011989 and Decitabine potently abrogated the inhibition of macrophage infiltration and thus suppressed tumor growth, the effect of which was impaired by CCL2 neutralization or macrophage depletion. Decitabine 133-143 C-C motif chemokine ligand 2 Homo sapiens 275-279 33248157-5 2021 Gefitinib increased Mcp-1 transcription level via the nuclear import of the transcription factor STAT3. Gefitinib 0-9 C-C motif chemokine ligand 2 Homo sapiens 20-25 33248157-7 2021 MCP-1 antibody or inhibition of STAT3 activation may represent novel therapeutic strategies for preventing gefitinib-induced pulmonary toxicity. Gefitinib 107-116 C-C motif chemokine ligand 2 Homo sapiens 0-5 33357907-4 2021 Higher DDA induced a more pronounced increase in alkaline phosphatase activity, osteopontin (OPN), vascular endothelial growth factor-A (VEGF), interleukin-6 (IL-6), and reduction in monocyte chemoattractant protein-1 (MCP-1), sclerostin (SOST) and dickkopf related protein-1 as compared to lower DDA. dda 7-10 C-C motif chemokine ligand 2 Homo sapiens 183-217 33357907-4 2021 Higher DDA induced a more pronounced increase in alkaline phosphatase activity, osteopontin (OPN), vascular endothelial growth factor-A (VEGF), interleukin-6 (IL-6), and reduction in monocyte chemoattractant protein-1 (MCP-1), sclerostin (SOST) and dickkopf related protein-1 as compared to lower DDA. dda 7-10 C-C motif chemokine ligand 2 Homo sapiens 219-224 33644540-11 2021 Results: The upregulated iNOS, excessive production of NO, IL-6, and MCP-1, and activated COX-2/PGE2 signaling pathways in the astrocytes induced by isoflurane were significantly reversed by the introduction of roflumilast, in a dose-dependent manner. Isoflurane 149-159 C-C motif chemokine ligand 2 Homo sapiens 69-74 33572154-6 2021 Intracellular calcium responses to ATP indicated differentiation of the functional astrocyte population with constitutive monocyte chemoattractant protein-1 (MCP-1/CCL2) and tissue inhibitor of metalloproteinases-2 (TIMP-2) expression. Calcium 14-21 C-C motif chemokine ligand 2 Homo sapiens 122-156 33572154-6 2021 Intracellular calcium responses to ATP indicated differentiation of the functional astrocyte population with constitutive monocyte chemoattractant protein-1 (MCP-1/CCL2) and tissue inhibitor of metalloproteinases-2 (TIMP-2) expression. Calcium 14-21 C-C motif chemokine ligand 2 Homo sapiens 158-163 33572154-6 2021 Intracellular calcium responses to ATP indicated differentiation of the functional astrocyte population with constitutive monocyte chemoattractant protein-1 (MCP-1/CCL2) and tissue inhibitor of metalloproteinases-2 (TIMP-2) expression. Calcium 14-21 C-C motif chemokine ligand 2 Homo sapiens 164-168 33572154-6 2021 Intracellular calcium responses to ATP indicated differentiation of the functional astrocyte population with constitutive monocyte chemoattractant protein-1 (MCP-1/CCL2) and tissue inhibitor of metalloproteinases-2 (TIMP-2) expression. Adenosine Triphosphate 35-38 C-C motif chemokine ligand 2 Homo sapiens 122-156 33572154-6 2021 Intracellular calcium responses to ATP indicated differentiation of the functional astrocyte population with constitutive monocyte chemoattractant protein-1 (MCP-1/CCL2) and tissue inhibitor of metalloproteinases-2 (TIMP-2) expression. Adenosine Triphosphate 35-38 C-C motif chemokine ligand 2 Homo sapiens 158-163 33572154-6 2021 Intracellular calcium responses to ATP indicated differentiation of the functional astrocyte population with constitutive monocyte chemoattractant protein-1 (MCP-1/CCL2) and tissue inhibitor of metalloproteinases-2 (TIMP-2) expression. Adenosine Triphosphate 35-38 C-C motif chemokine ligand 2 Homo sapiens 164-168 33559345-9 2021 Human renal cells treated with CPT or TPT had reduced expression of Fli-1 and decreased MCP1 following stimulation with IFN-alpha or IFN-gamma. Topotecan 38-41 C-C motif chemokine ligand 2 Homo sapiens 88-92 33567502-11 2021 Acrylamide induced histone H3K4 and H3K36 tri-methylation in an SDHA promoter and increased mitophagy-related PINK1 expression, which promoted a M2-like phenotypic switch with increase TGF-beta and CCL2 levels in THP-1 cells. Acrylamide 0-10 C-C motif chemokine ligand 2 Homo sapiens 198-202 33395292-8 2021 Other typical fragment-ions produced from protonated metallocenes included the M(cp)1+ ions (M = Fe or Ni), by elimination of a cyclopentadiene molecule, or the molecular cation, by loss of a H radical. protonated metallocenes 42-65 C-C motif chemokine ligand 2 Homo sapiens 79-85 33395292-8 2021 Other typical fragment-ions produced from protonated metallocenes included the M(cp)1+ ions (M = Fe or Ni), by elimination of a cyclopentadiene molecule, or the molecular cation, by loss of a H radical. Iron 97-99 C-C motif chemokine ligand 2 Homo sapiens 79-85 33395292-8 2021 Other typical fragment-ions produced from protonated metallocenes included the M(cp)1+ ions (M = Fe or Ni), by elimination of a cyclopentadiene molecule, or the molecular cation, by loss of a H radical. Cyclopentanes 128-143 C-C motif chemokine ligand 2 Homo sapiens 79-85 33561155-11 2021 The highly intensified receptor interaction of BPC is attributable to the presence of an n-pi-pi-n conjugation system mediated through the >C = CCl2 double bond. bpc 47-50 C-C motif chemokine ligand 2 Homo sapiens 144-148 33561155-11 2021 The highly intensified receptor interaction of BPC is attributable to the presence of an n-pi-pi-n conjugation system mediated through the >C = CCl2 double bond. Nitrogen 12-13 C-C motif chemokine ligand 2 Homo sapiens 144-148 33561155-11 2021 The highly intensified receptor interaction of BPC is attributable to the presence of an n-pi-pi-n conjugation system mediated through the >C = CCl2 double bond. Nitrogen 15-16 C-C motif chemokine ligand 2 Homo sapiens 144-148 33561155-11 2021 The highly intensified receptor interaction of BPC is attributable to the presence of an n-pi-pi-n conjugation system mediated through the >C = CCl2 double bond. Carbon 49-50 C-C motif chemokine ligand 2 Homo sapiens 144-148 33644540-11 2021 Results: The upregulated iNOS, excessive production of NO, IL-6, and MCP-1, and activated COX-2/PGE2 signaling pathways in the astrocytes induced by isoflurane were significantly reversed by the introduction of roflumilast, in a dose-dependent manner. Roflumilast 211-222 C-C motif chemokine ligand 2 Homo sapiens 69-74 33217242-4 2021 BK activation with NS1619 decreased LPS-induced CCL-2 but not IL-6 secretion from endothelial cells and had no effect on epithelial cells, although fluorometric assays revealed that BK activation hyperpolarized the plasma membrane potential (Em) of both cell types. NS 1619 19-25 C-C motif chemokine ligand 2 Homo sapiens 48-53 32363436-6 2021 In addition, CMBL5-LO inhibited several chemo-attractants, including interleukin (IL)-6, macrophage inflammatory protein (MIP)-2, chemokine (C-C motif) ligand 5 (CCL5), granulocyte colony-stimulating factor (GCSF), and monocyte chemoattractant protein-1 (MCP-1) expression. cmbl5-lo 13-21 C-C motif chemokine ligand 2 Homo sapiens 219-253 33369712-11 2021 The effects of ASIV on reducing CCL2 production, restoring acetylated p65 levels and preventing p65 nuclear translocation were mimicked by valproate, an HDAC inhibitor, in astrocytes subjected to oxygen-glucose deprivation. Valproic Acid 139-148 C-C motif chemokine ligand 2 Homo sapiens 32-36 32659104-7 2021 Colchicine did modulate the NOD-like receptor family pyrin domain containing 3 inflammasome in 3 studies and reduced production of chemokine ligand 2 (CCL2), CCL5, and C-X3-C motif chemokine ligand 1 in 1 study. Colchicine 0-10 C-C motif chemokine ligand 2 Homo sapiens 151-155 32363436-6 2021 In addition, CMBL5-LO inhibited several chemo-attractants, including interleukin (IL)-6, macrophage inflammatory protein (MIP)-2, chemokine (C-C motif) ligand 5 (CCL5), granulocyte colony-stimulating factor (GCSF), and monocyte chemoattractant protein-1 (MCP-1) expression. cmbl5-lo 13-21 C-C motif chemokine ligand 2 Homo sapiens 255-260 33575345-4 2021 Sudachitin inhibited IL-1beta-induced IL-6, IL-8, CXC chemokine ligand (CXCL)10, CC chemokine ligand (CCL)2, MMP-1, and MMP-3 production in HPDLC. sudachitin 0-10 C-C motif chemokine ligand 2 Homo sapiens 102-107 33278444-9 2021 Moreover, quercetin-glycyrrhizin nanogels were more effective in down-regulating the inflammation-related gene expression of tumor necrosis factor-alpha, interleukin-6, inducible nitric oxide synthase and monocyte chemotactic protein-1. Quercetin 10-19 C-C motif chemokine ligand 2 Homo sapiens 205-235 33278444-9 2021 Moreover, quercetin-glycyrrhizin nanogels were more effective in down-regulating the inflammation-related gene expression of tumor necrosis factor-alpha, interleukin-6, inducible nitric oxide synthase and monocyte chemotactic protein-1. Glycyrrhizic Acid 20-32 C-C motif chemokine ligand 2 Homo sapiens 205-235 33485352-9 2021 Baicalein significantly attenuated the inflammatory factors induced by LPS, including interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), matrix metalloprotein-1 (MMP-1), MMP-2 and monocyte chemoattractant protein 1 (MCP-1) at both mRNA and protein level. baicalein 0-9 C-C motif chemokine ligand 2 Homo sapiens 200-234 33485352-9 2021 Baicalein significantly attenuated the inflammatory factors induced by LPS, including interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), matrix metalloprotein-1 (MMP-1), MMP-2 and monocyte chemoattractant protein 1 (MCP-1) at both mRNA and protein level. baicalein 0-9 C-C motif chemokine ligand 2 Homo sapiens 236-241 33070717-10 2021 Decoupling the interaction between mobilized neutrophils/T cells and the neurovascular unit, achieved via a sphingosine-1-phosphate receptor 1 modulator RP101075 and a CCL2 synthesis inhibitor bindarit, which block lymphocyte egress and myeloid cell recruitment, respectively, attenuates hemorrhagic transformation and improves neurological function after tPA thrombolysis. bindarit 193-201 C-C motif chemokine ligand 2 Homo sapiens 168-172 33614913-5 2021 Intratumoral injection of vanadyl sulfate, a pan-inhibitor of protein tyrosine phosphatases, in combination with NDV significantly increased the number and activation status of natural killer (NK) cells in the tumor microenvironment, concomitant with increased expression of interferon-beta, granulocyte-macrophage colony-stimulating factor, and monocyte chemoattractant protein-1, leading to rapid tumor regression and long-term cures in mice bearing syngeneic B16-F10 melanomas. vanadyl sulfate 26-41 C-C motif chemokine ligand 2 Homo sapiens 346-380 33467441-7 2021 Ibrutinib achieves a reduction in the production of TNFalpha, IL1, IL-6 and Monocyte chemo-attractant protein-1 (MCP-1) by neutrophils and macrophages, that are key players in keeping the inflammatory process. ibrutinib 0-9 C-C motif chemokine ligand 2 Homo sapiens 76-111 33467441-7 2021 Ibrutinib achieves a reduction in the production of TNFalpha, IL1, IL-6 and Monocyte chemo-attractant protein-1 (MCP-1) by neutrophils and macrophages, that are key players in keeping the inflammatory process. ibrutinib 0-9 C-C motif chemokine ligand 2 Homo sapiens 113-118 33435371-5 2021 ART treatment induced an increase in inflammatory monocytes (CD14highCD16-) with HLA-DR high expression and MCP-1/IL-1beta release. Artesunate 0-3 C-C motif chemokine ligand 2 Homo sapiens 108-113 33489875-5 2020 At all three time points, Emodin (50 mg/kg) reduced inflammatory cell (i.e. CD11b+ and F4/80+) recruitment, cytokine (i.e. TNFalpha, IL1alpha/beta, IL6, CCL2, CXCL5) and pro-inflammatory enzymes (i.e. COX-2, NOS2) expression in the tumor microenvironment, while promoting recruitment of CD3+ T lymphocytes at 14 weeks. Emodin 26-32 C-C motif chemokine ligand 2 Homo sapiens 153-157 33488575-5 2020 Ceftazidime inhibited integrin signaling via Syk, including inhibition of adhesion-dependent upregulation of interleukin-1beta and monocyte chemoattractant protein-1, but did not inhibit ITAM-dependent phosphorylation of Syk mediated by FcgammaRI signaling. Ceftazidime 0-11 C-C motif chemokine ligand 2 Homo sapiens 131-165 33254416-7 2021 RESULTS: Among 27 cytokines, IL-9 and MIP1-alpha were significantly lower, but IL-4, IL-10, IL-15, MCP-1, TNF-alpha and VEGF were significantly higher in benzene exposure group than controls. Benzene 154-161 C-C motif chemokine ligand 2 Homo sapiens 99-104 33442507-6 2021 GST-hCCL2 was successfully induced by 0.1 mmol/L IPTG at 20 C for 6 h, and the recombinant protein was purified using affinity chromatography. Isopropyl Thiogalactoside 49-53 C-C motif chemokine ligand 2 Homo sapiens 4-9 33303222-5 2021 EPA lowered TNFA (p < 0.001) whereas DHA reduced TNFA (p < 0.001), IL6 (p < 0.02), MCP1 (p < 0.03), and IL10 (p < 0.01). Docosahexaenoic Acids 37-40 C-C motif chemokine ligand 2 Homo sapiens 83-87 33303222-7 2021 Relative to baseline, EPA, but not DHA, decreased the ratios of TNFA/IL10 and MCP1/IL10 (both p < 0.01). Eicosapentaenoic Acid 22-25 C-C motif chemokine ligand 2 Homo sapiens 78-82 33618532-10 2021 RESULTS: In our study, serum MCP-1 levels were significantly higher in cyclosporine and tacrolimus groups than in sirolimus (p<0.05). Cyclosporine 71-83 C-C motif chemokine ligand 2 Homo sapiens 29-34 33618532-10 2021 RESULTS: In our study, serum MCP-1 levels were significantly higher in cyclosporine and tacrolimus groups than in sirolimus (p<0.05). Tacrolimus 88-98 C-C motif chemokine ligand 2 Homo sapiens 29-34 33618532-10 2021 RESULTS: In our study, serum MCP-1 levels were significantly higher in cyclosporine and tacrolimus groups than in sirolimus (p<0.05). Sirolimus 114-123 C-C motif chemokine ligand 2 Homo sapiens 29-34 31657689-8 2021 CCL2 mRNA expression significantly reduced only followed by treatment of these cells with high dose of M2000, whereas, mRNA and cell surface expressions of CCR2 diminished significantly followed by treatment of these cells with high dose of M2000 and optimum dose of diclofenac. Diclofenac 267-277 C-C motif chemokine ligand 2 Homo sapiens 0-4 33325132-0 2021 Resveratrol treatment reduces expression of MCP-1, IL-6, IL-8 and RANTES in endometriotic stromal cells. Resveratrol 0-11 C-C motif chemokine ligand 2 Homo sapiens 44-49 33285354-6 2021 The highest levels of IL-1beta, IL-6, CCL2 and IL-8 were observed with MSU at 0.5 mg/ml, CPP at 0.01-0.05 mg/ml and BCP at 1 mg/ml after 18-48 h and then decreased. Uric Acid 71-74 C-C motif chemokine ligand 2 Homo sapiens 38-42 33285354-6 2021 The highest levels of IL-1beta, IL-6, CCL2 and IL-8 were observed with MSU at 0.5 mg/ml, CPP at 0.01-0.05 mg/ml and BCP at 1 mg/ml after 18-48 h and then decreased. bcp 116-119 C-C motif chemokine ligand 2 Homo sapiens 38-42 33325132-3 2021 In this study, we evaluated the effects of resveratrol treatment on expression of monocyte chemotactic protein-1 (MCP-1), interleukin-6 (IL-6), IL-8, and regulated upon activation, normal T cell expressed and secreted (RANTES) in endometrial stromal cells from patients with endometriosis compared with non-endometriotic controls. Resveratrol 43-54 C-C motif chemokine ligand 2 Homo sapiens 82-112 33325132-3 2021 In this study, we evaluated the effects of resveratrol treatment on expression of monocyte chemotactic protein-1 (MCP-1), interleukin-6 (IL-6), IL-8, and regulated upon activation, normal T cell expressed and secreted (RANTES) in endometrial stromal cells from patients with endometriosis compared with non-endometriotic controls. Resveratrol 43-54 C-C motif chemokine ligand 2 Homo sapiens 114-119 33325132-5 2021 Resveratrol treatment significantly reduced gene and protein expression of MCP-1, IL-6, and IL-8 in EuESCs and EESCs compared with CESCs (P < .05-.001, P < .05-.001 and P < .05-<.01, respectively), and this reduction was more noticeable in EESCs than EuESCs (P < .05-<.001). Resveratrol 0-11 C-C motif chemokine ligand 2 Homo sapiens 75-80 33325132-7 2021 Resveratrol treatment significantly reduced the expression of MCP-1, IL-6, IL-8 and RANTES in EESCs. Resveratrol 0-11 C-C motif chemokine ligand 2 Homo sapiens 62-67 33283480-8 2021 C-NP nanoparticles also stimulate the release of IL-lbeta, MCP-1, TNF-alpha, IL-8, IL-12p70, IL-17, IL-18, and IL-23 from MDM. c-np 0-4 C-C motif chemokine ligand 2 Homo sapiens 59-64 33277387-5 2021 We showed that MCP-1 induces Src phosphorylation in a similar time frame and that the MCP-1-induced Pyk2 tyrosine phosphorylation is controlled by the Src family kinase. Tyrosine 105-113 C-C motif chemokine ligand 2 Homo sapiens 86-91 33369072-10 2021 Increased spontaneous secretion of CCL2 and CCL5 and decreased secretion of CCL2, upon stimulation with PI and pIA2, in LADA compared to T1D and T2D could reflect altered immune responsiveness in LADA patients in association with their slower clinical progression compared to insulin dependence. pia2 111-115 C-C motif chemokine ligand 2 Homo sapiens 76-80 33379375-0 2020 Effect of Essential Oils on the Release of TNF-alpha and CCL2 by LPS-Stimulated THP-1 Cells. Oils, Volatile 10-24 C-C motif chemokine ligand 2 Homo sapiens 57-61 33179090-9 2021 Co-treatment with apelin-36 alleviated LPS-induced lung injury and pulmonary edema, reduced the levels of pro-inflammatory cytokines, including interleukin-6, monocyte chemoattractant protein-1 and tumor necrosis factor-alpha, in BALF, and inhibited apoptosis in the lung tissues. APELIN-36 18-27 C-C motif chemokine ligand 2 Homo sapiens 159-193 33447046-6 2020 SB was able to significantly prevent the increase of GM-CSF, MCP-1, IL-6 IL-12, and IL-13 triggered by LPS. Butyric Acid 0-2 C-C motif chemokine ligand 2 Homo sapiens 61-66 33447046-8 2020 IPA pre-treatment prevented the LPS-induced increase in MCP-1, IL-12, IL-13, and TNF-alpha levels 24 hours after pre-treatment, but had no effect on tryptophan metabolites. ipa 0-3 C-C motif chemokine ligand 2 Homo sapiens 56-61 33839684-5 2021 In PC3 cells, Stattic alone inhibited gene expression of CCL20 and CCL2, but activated expression of TNFA, CEBPD, SOX2, and MYC. stattic 14-21 C-C motif chemokine ligand 2 Homo sapiens 57-61 33356884-6 2021 Nicaraven suppressed TNFalpha-induced mRNA expression of multiple adhesion molecules and pro-inflammatory cytokines, including VCAM-1, ICAM-1, E-selectin, MCP-1, TNFalpha, IL-1beta, IL-6 and IL-8. nicaraven 0-9 C-C motif chemokine ligand 2 Homo sapiens 155-160 33381602-2 2020 In the present study, effort was made to find out the association of CCL2-2518 A>G and -362 G>C variants with susceptibility to TB in a population from North India. Terbium 128-130 C-C motif chemokine ligand 2 Homo sapiens 69-73 33614926-6 2021 Roxithromycin increased levels of IP-10 (P = .049) and decreased levels of MCP-1 (P < .001), MIP-1alpha (P < .016), ENA-78 (P < .001), and IL-8 (P < .001). Roxithromycin 0-13 C-C motif chemokine ligand 2 Homo sapiens 75-80 33381602-14 2020 It may be hypothesized from the findings that -2518G allele could be responsible for lower production of CCL2 which leads to defective Th1 response and makes a host susceptible for pulmonary tuberculosis. 2-(beta-D-glucosyl)benzothiazole 135-138 C-C motif chemokine ligand 2 Homo sapiens 105-109 33365026-6 2020 In vitro treatment with 1,25(OH)2D3 reduced proinflammatory cytokines (IL-6, CCL-2, IL-23A, IL-15) whereas anti-inflammatory cytokines (IL-10 and PD-L1) rose both in APS-type 1 diabetes and APS-Addison s disease. Calcitriol 24-35 C-C motif chemokine ligand 2 Homo sapiens 77-82 33363471-6 2020 Results: At a clinically relevant concentration (1 nM), roflumilast N-oxide and roflumilast consistently reduced the release of TNF-alpha, CCL2, CCL3, CCL4, CCL5 and CXCL9 (but not CXCL1, CXCL5, CXCL8 and IL-6) from human bronchial explants. Roflumilast 56-67 C-C motif chemokine ligand 2 Homo sapiens 139-143 33363471-6 2020 Results: At a clinically relevant concentration (1 nM), roflumilast N-oxide and roflumilast consistently reduced the release of TNF-alpha, CCL2, CCL3, CCL4, CCL5 and CXCL9 (but not CXCL1, CXCL5, CXCL8 and IL-6) from human bronchial explants. n-oxide 68-75 C-C motif chemokine ligand 2 Homo sapiens 139-143 33363471-6 2020 Results: At a clinically relevant concentration (1 nM), roflumilast N-oxide and roflumilast consistently reduced the release of TNF-alpha, CCL2, CCL3, CCL4, CCL5 and CXCL9 (but not CXCL1, CXCL5, CXCL8 and IL-6) from human bronchial explants. Roflumilast 80-91 C-C motif chemokine ligand 2 Homo sapiens 139-143 33363471-7 2020 Formoterol alone decreased the release of TNF-alpha, CCL2, and CCL3. Formoterol Fumarate 0-10 C-C motif chemokine ligand 2 Homo sapiens 53-57 33363471-8 2020 The combination of formoterol with roflumilast (1 nM) was more potent than roflumilast alone for inhibiting the LPS-induced release of TNF-alpha, CCL2, CCL3, CCL4, and CXCL9 by the bronchial explants. Formoterol Fumarate 19-29 C-C motif chemokine ligand 2 Homo sapiens 146-150 33363471-8 2020 The combination of formoterol with roflumilast (1 nM) was more potent than roflumilast alone for inhibiting the LPS-induced release of TNF-alpha, CCL2, CCL3, CCL4, and CXCL9 by the bronchial explants. Roflumilast 35-46 C-C motif chemokine ligand 2 Homo sapiens 146-150 33017186-7 2020 Finally, TMP195 inhibited LPS-induced upregulation of multiple proinflammatory cytokines/chemokines, including ICAM-1, MCP-1, TNF-alpha, and IL-1beta and accumulation of inflammatory cells in the injured kidney. TMP195 9-15 C-C motif chemokine ligand 2 Homo sapiens 119-124 33520015-11 2020 Finally, 6 key proteins of TNF, IL-10, IL-2, IL-6, STAT1 and CCL2 were selected and successfully docked with 4 active ingredients of quercetin, luteolin, wogonin and kaempferol. Quercetin 133-142 C-C motif chemokine ligand 2 Homo sapiens 61-65 33520015-11 2020 Finally, 6 key proteins of TNF, IL-10, IL-2, IL-6, STAT1 and CCL2 were selected and successfully docked with 4 active ingredients of quercetin, luteolin, wogonin and kaempferol. Luteolin 144-152 C-C motif chemokine ligand 2 Homo sapiens 61-65 33520015-11 2020 Finally, 6 key proteins of TNF, IL-10, IL-2, IL-6, STAT1 and CCL2 were selected and successfully docked with 4 active ingredients of quercetin, luteolin, wogonin and kaempferol. wogonin 154-161 C-C motif chemokine ligand 2 Homo sapiens 61-65 33520015-11 2020 Finally, 6 key proteins of TNF, IL-10, IL-2, IL-6, STAT1 and CCL2 were selected and successfully docked with 4 active ingredients of quercetin, luteolin, wogonin and kaempferol. kaempferol 166-176 C-C motif chemokine ligand 2 Homo sapiens 61-65 32991874-12 2020 Furthermore, we found that NT5DC2 deletion obviously reduced the TAM recruitments through suppressing CCL2/CCR2 and AKT/NF-kappaB signaling pathways. tam 65-68 C-C motif chemokine ligand 2 Homo sapiens 102-106 33401355-4 2020 RESULTS: The mean pretreatment urinary MCP-1 level at visit 1 (229.2-pg/mg creatinine) was significantly greater than the MCP-1 levels at visit 3 in both the treatment (107.0-pg/mg creatinine) (P<0.001) and control (52.35-pg/mg creatinine) groups (P<0.001). Creatinine 75-85 C-C motif chemokine ligand 2 Homo sapiens 39-44 33049493-8 2020 Our results showed that trelagliptin inhibited the expression of pro-inflammatory chemokines including monocyte chemoattractant protein 1 (MCP-1), CXCL-1, and IL-6. trelagliptin 24-36 C-C motif chemokine ligand 2 Homo sapiens 103-137 33049493-8 2020 Our results showed that trelagliptin inhibited the expression of pro-inflammatory chemokines including monocyte chemoattractant protein 1 (MCP-1), CXCL-1, and IL-6. trelagliptin 24-36 C-C motif chemokine ligand 2 Homo sapiens 139-144 33049495-8 2020 Juglanin also inhibits the inflammatory response by suppressing OSS-induced expressions of IL-1beta, MCP-1, and HMGB1. juglanin 0-8 C-C motif chemokine ligand 2 Homo sapiens 101-106 33401355-4 2020 RESULTS: The mean pretreatment urinary MCP-1 level at visit 1 (229.2-pg/mg creatinine) was significantly greater than the MCP-1 levels at visit 3 in both the treatment (107.0-pg/mg creatinine) (P<0.001) and control (52.35-pg/mg creatinine) groups (P<0.001). Creatinine 181-191 C-C motif chemokine ligand 2 Homo sapiens 39-44 33401355-4 2020 RESULTS: The mean pretreatment urinary MCP-1 level at visit 1 (229.2-pg/mg creatinine) was significantly greater than the MCP-1 levels at visit 3 in both the treatment (107.0-pg/mg creatinine) (P<0.001) and control (52.35-pg/mg creatinine) groups (P<0.001). Creatinine 181-191 C-C motif chemokine ligand 2 Homo sapiens 39-44 33075233-4 2020 The present study hypothesized that non-toxic concentrations of Cd (as cadmium chloride [CdCl2]) could up-regulate CCL2 production in U-87 MG human glio-blastoma cells. Cadmium 64-66 C-C motif chemokine ligand 2 Homo sapiens 115-119 33075233-4 2020 The present study hypothesized that non-toxic concentrations of Cd (as cadmium chloride [CdCl2]) could up-regulate CCL2 production in U-87 MG human glio-blastoma cells. Cadmium Chloride 71-87 C-C motif chemokine ligand 2 Homo sapiens 115-119 33075233-0 2020 Cadmium induces CCL2 production in glioblastoma cells via activation of MAPK, PI3K, and PKC pathways. Cadmium 0-7 C-C motif chemokine ligand 2 Homo sapiens 16-20 33075233-4 2020 The present study hypothesized that non-toxic concentrations of Cd (as cadmium chloride [CdCl2]) could up-regulate CCL2 production in U-87 MG human glio-blastoma cells. Cadmium Chloride 89-94 C-C motif chemokine ligand 2 Homo sapiens 115-119 33075233-5 2020 The results showed that after exposure of the U-87 MG cells to CdCl2 at 1 and 10 microM, there was an up-regulation of CCL2 mRNA expression after 3 h of exposure and increased CCL2 secretion after 6 and 24 h. The study also found that inhibition of MAPK pathways, including ERK1/2, p38, and JNK by U0126, SB203580 and SP600125, respectively, reduced Cd-induced CCL2 secretion by the cells. Cadmium Chloride 63-68 C-C motif chemokine ligand 2 Homo sapiens 119-123 33075233-5 2020 The results showed that after exposure of the U-87 MG cells to CdCl2 at 1 and 10 microM, there was an up-regulation of CCL2 mRNA expression after 3 h of exposure and increased CCL2 secretion after 6 and 24 h. The study also found that inhibition of MAPK pathways, including ERK1/2, p38, and JNK by U0126, SB203580 and SP600125, respectively, reduced Cd-induced CCL2 secretion by the cells. Cadmium Chloride 63-68 C-C motif chemokine ligand 2 Homo sapiens 176-180 33075233-5 2020 The results showed that after exposure of the U-87 MG cells to CdCl2 at 1 and 10 microM, there was an up-regulation of CCL2 mRNA expression after 3 h of exposure and increased CCL2 secretion after 6 and 24 h. The study also found that inhibition of MAPK pathways, including ERK1/2, p38, and JNK by U0126, SB203580 and SP600125, respectively, reduced Cd-induced CCL2 secretion by the cells. Cadmium Chloride 63-68 C-C motif chemokine ligand 2 Homo sapiens 176-180 33075233-5 2020 The results showed that after exposure of the U-87 MG cells to CdCl2 at 1 and 10 microM, there was an up-regulation of CCL2 mRNA expression after 3 h of exposure and increased CCL2 secretion after 6 and 24 h. The study also found that inhibition of MAPK pathways, including ERK1/2, p38, and JNK by U0126, SB203580 and SP600125, respectively, reduced Cd-induced CCL2 secretion by the cells. Cadmium 63-65 C-C motif chemokine ligand 2 Homo sapiens 119-123 33075233-5 2020 The results showed that after exposure of the U-87 MG cells to CdCl2 at 1 and 10 microM, there was an up-regulation of CCL2 mRNA expression after 3 h of exposure and increased CCL2 secretion after 6 and 24 h. The study also found that inhibition of MAPK pathways, including ERK1/2, p38, and JNK by U0126, SB203580 and SP600125, respectively, reduced Cd-induced CCL2 secretion by the cells. Cadmium 63-65 C-C motif chemokine ligand 2 Homo sapiens 176-180 33075233-5 2020 The results showed that after exposure of the U-87 MG cells to CdCl2 at 1 and 10 microM, there was an up-regulation of CCL2 mRNA expression after 3 h of exposure and increased CCL2 secretion after 6 and 24 h. The study also found that inhibition of MAPK pathways, including ERK1/2, p38, and JNK by U0126, SB203580 and SP600125, respectively, reduced Cd-induced CCL2 secretion by the cells. Cadmium 63-65 C-C motif chemokine ligand 2 Homo sapiens 176-180 32815569-6 2020 Owing to its plethora of surface receptors, pericytes respond to inflammatory mediators such as CCL2 (monocyte chemoattractant protein-1) and tumor necrosis factor-alpha, in turn secreting CCL2, nitric oxide, and several cytokines. Nitric Oxide 195-207 C-C motif chemokine ligand 2 Homo sapiens 96-100 33075233-6 2020 Moreover, when cells were pretreated with Ro 32-0432 (an inhibitor of calcium-dependent PKC) and LY294002 (a PI3K inhibitor), this also resulted in a down-regulation of any Cd-induced CCL2 expression. Ro 32-0432 42-52 C-C motif chemokine ligand 2 Homo sapiens 184-188 32815569-6 2020 Owing to its plethora of surface receptors, pericytes respond to inflammatory mediators such as CCL2 (monocyte chemoattractant protein-1) and tumor necrosis factor-alpha, in turn secreting CCL2, nitric oxide, and several cytokines. Nitric Oxide 195-207 C-C motif chemokine ligand 2 Homo sapiens 102-136 33075233-6 2020 Moreover, when cells were pretreated with Ro 32-0432 (an inhibitor of calcium-dependent PKC) and LY294002 (a PI3K inhibitor), this also resulted in a down-regulation of any Cd-induced CCL2 expression. Calcium 70-77 C-C motif chemokine ligand 2 Homo sapiens 184-188 33075233-6 2020 Moreover, when cells were pretreated with Ro 32-0432 (an inhibitor of calcium-dependent PKC) and LY294002 (a PI3K inhibitor), this also resulted in a down-regulation of any Cd-induced CCL2 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 97-105 C-C motif chemokine ligand 2 Homo sapiens 184-188 33075233-6 2020 Moreover, when cells were pretreated with Ro 32-0432 (an inhibitor of calcium-dependent PKC) and LY294002 (a PI3K inhibitor), this also resulted in a down-regulation of any Cd-induced CCL2 expression. Cadmium 173-175 C-C motif chemokine ligand 2 Homo sapiens 184-188 33075233-7 2020 Taken together, the results of this study allow for the conclusion to be made that CCL2 up-regulation in U-87 MG cells induced by Cd is mediated, in part, by an activation of MAPK, PI3K/Akt, and PKC pathways. Cadmium 130-132 C-C motif chemokine ligand 2 Homo sapiens 83-87 33244468-8 2020 Laquinimod significantly downregulated the expression of chemokines (monocyte chemotactic protein-1 and macrophage inflammatory protein-1), pro-inflammatory cytokines (interleukin-1beta and tumor necrosis factor-alpha), vascular endothelial growth factor, nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 and apoptosis-associated speck-like protein containing C-terminal caspase-recruitment domain adaptor protein in both injured corneas and RAW cells. laquinimod 0-10 C-C motif chemokine ligand 2 Homo sapiens 69-99 33012706-5 2020 Ensifentrine reduced the production of monocyte chemoattractant protein-1 and granulocyte monocyte colony-stimulating factor (GM-CSF) during challenge with interleukin-1beta Comparing the effect of ensifentrine with milrinone and roflumilast, selective PDE3 and PDE4 inhibitors, respectively, demonstrated that the anti-inflammatory effect of ensifentrine was mainly due to inhibition of PDE4. ensifentrine 0-12 C-C motif chemokine ligand 2 Homo sapiens 39-73 33228788-5 2020 Furthermore, after adjusting for potentials cofounders, it was revealed that the subjects with lower DII had lower monocyte chemoattractant protein-1 (MCP-1) levels in serum (beta = - 18.81, 95% CI - 35.84, - 1.79, p = 0.03). dilC18(3) dye 101-104 C-C motif chemokine ligand 2 Homo sapiens 115-149 33228788-5 2020 Furthermore, after adjusting for potentials cofounders, it was revealed that the subjects with lower DII had lower monocyte chemoattractant protein-1 (MCP-1) levels in serum (beta = - 18.81, 95% CI - 35.84, - 1.79, p = 0.03). dilC18(3) dye 101-104 C-C motif chemokine ligand 2 Homo sapiens 151-156 33228788-6 2020 These findings suggest an inverse and significant relationship between DII and FFM and also DII is directly related to Fat mass and the level of MCP-1. dilC18(3) dye 92-95 C-C motif chemokine ligand 2 Homo sapiens 145-150 32382733-1 2020 On human lung parenchymal explants, chloroquine concentration clinically achievable in the lung (100 muM) inhibited the lipopolysaccharide-induced release of TNF-alpha (by 76%), IL-6 (by 68%), CCL2 (by 72%) and CCL3 (by 67%). Chloroquine 36-47 C-C motif chemokine ligand 2 Homo sapiens 193-197 33228017-9 2020 In vitro, dapagliflozin reduced monocyte chemoattractant protein-1 release under high-glucose conditions in human and murine peritoneal mesothelial cells. dapagliflozin 10-23 C-C motif chemokine ligand 2 Homo sapiens 32-66 33228017-9 2020 In vitro, dapagliflozin reduced monocyte chemoattractant protein-1 release under high-glucose conditions in human and murine peritoneal mesothelial cells. Glucose 86-93 C-C motif chemokine ligand 2 Homo sapiens 32-66 33245731-8 2020 TMPRSS2, inflammatory cytokines G-CSF, M-CSF, IL-1alpha, IL-6 and MCP-1 are suppressed by MEKi alone or with remdesivir. remdesivir 109-119 C-C motif chemokine ligand 2 Homo sapiens 66-71 32961113-5 2020 This study aims to highlight for the first time the capability of theobromine in protecting the intestinal cell monolayer from a mixture of dietary oxysterols showing an inflammatory action in terms of IL-8 and MCP-1 overproduction. Theobromine 66-77 C-C motif chemokine ligand 2 Homo sapiens 211-216 32881004-5 2020 The TvSP-stimulated human mast cell line (HMC-1) exhibited significantly increased monocyte chemoattractant protein-1 (MCP-1) secretion compared to the unstimulated cells. tvsp 4-8 C-C motif chemokine ligand 2 Homo sapiens 83-117 32881004-5 2020 The TvSP-stimulated human mast cell line (HMC-1) exhibited significantly increased monocyte chemoattractant protein-1 (MCP-1) secretion compared to the unstimulated cells. tvsp 4-8 C-C motif chemokine ligand 2 Homo sapiens 119-124 33180478-7 2020 VPP and IPP reduced the protein levels of IL-6 to 227.34 +- 10.56 and 273.84 +- 22.28 pg/mL, of IL-1beta protein to 131.56 +- 23.18 and 221.14 +- 13.8 pg/mL, and of MCP-1 to 301.48 +- 19.75 and 428.68 +- 9.59 pg/mL. valyl-prolyl-proline 0-3 C-C motif chemokine ligand 2 Homo sapiens 165-170 33180478-7 2020 VPP and IPP reduced the protein levels of IL-6 to 227.34 +- 10.56 and 273.84 +- 22.28 pg/mL, of IL-1beta protein to 131.56 +- 23.18 and 221.14 +- 13.8 pg/mL, and of MCP-1 to 301.48 +- 19.75 and 428.68 +- 9.59 pg/mL. isoleucyl-prolyl-proline 8-11 C-C motif chemokine ligand 2 Homo sapiens 165-170 33228784-6 2020 CCL2 can enhance presynaptic calcium signal. Calcium 29-36 C-C motif chemokine ligand 2 Homo sapiens 0-4 33228784-7 2020 Whole-cell patch-clamp recordings showed that CCL2 can enhance NMDAR-eEPSCs through presynaptic effects, and further application of glutamate sensor method proved that CCL2 can act on presynaptic CCR2 to increase the release of presynaptic glutamate. Glutamic Acid 132-141 C-C motif chemokine ligand 2 Homo sapiens 168-172 33228784-7 2020 Whole-cell patch-clamp recordings showed that CCL2 can enhance NMDAR-eEPSCs through presynaptic effects, and further application of glutamate sensor method proved that CCL2 can act on presynaptic CCR2 to increase the release of presynaptic glutamate. Glutamic Acid 240-249 C-C motif chemokine ligand 2 Homo sapiens 168-172 33228784-8 2020 In conclusion, we suggest that CCL2 can directly act on the CCR2 on presynaptic terminals of sensory neurons in the spinal dorsal horn, leading to an increase in the release of presynaptic glutamate and participate in the formation of central sensitization. Glutamic Acid 189-198 C-C motif chemokine ligand 2 Homo sapiens 31-35 33215957-3 2020 GSSSG prevented the LPS-induced upregulation of interleukin (IL)-1beta, IL-6, and C-C motif chemokine ligand 2 (CCL2) in ARPE-19/primary RPE cells. glutathione trisulfide 0-5 C-C motif chemokine ligand 2 Homo sapiens 82-110 33215957-3 2020 GSSSG prevented the LPS-induced upregulation of interleukin (IL)-1beta, IL-6, and C-C motif chemokine ligand 2 (CCL2) in ARPE-19/primary RPE cells. glutathione trisulfide 0-5 C-C motif chemokine ligand 2 Homo sapiens 112-116 33215957-5 2020 ERK1/2 inhibition prevented the GSSSG-mediated inhibition of LPS-induced IL-6 and CCL2 upregulation. glutathione trisulfide 32-37 C-C motif chemokine ligand 2 Homo sapiens 82-86 33139635-0 2020 Empagliflozin Inhibits Basal and IL-1beta-Mediated MCP-1/CCL2 and Endothelin-1 Expression in Human Proximal Tubular Cells. empagliflozin 0-13 C-C motif chemokine ligand 2 Homo sapiens 51-56 33146789-10 2021 In addition, using the ROS inhibitor N-acetyl-L-cysteine (NAC), we observed abrogated mRNA expression of several ARPs and production of inflammatory cytokines/chemokines (IL-6, IL-8, MCP-1, and CCL-5) in the CSE-challenged cells suggesting an important role of ROS in regulating CSE-induced autophagy. ros 23-26 C-C motif chemokine ligand 2 Homo sapiens 183-188 33146789-10 2021 In addition, using the ROS inhibitor N-acetyl-L-cysteine (NAC), we observed abrogated mRNA expression of several ARPs and production of inflammatory cytokines/chemokines (IL-6, IL-8, MCP-1, and CCL-5) in the CSE-challenged cells suggesting an important role of ROS in regulating CSE-induced autophagy. Acetylcysteine 37-56 C-C motif chemokine ligand 2 Homo sapiens 183-188 33146789-10 2021 In addition, using the ROS inhibitor N-acetyl-L-cysteine (NAC), we observed abrogated mRNA expression of several ARPs and production of inflammatory cytokines/chemokines (IL-6, IL-8, MCP-1, and CCL-5) in the CSE-challenged cells suggesting an important role of ROS in regulating CSE-induced autophagy. Acetylcysteine 58-61 C-C motif chemokine ligand 2 Homo sapiens 183-188 32911202-0 2020 Effect of metformin and insulin combination on monocyte chemoattractant protein-1 and cathepsin-D in type 2 diabetes mellitus. Metformin 10-19 C-C motif chemokine ligand 2 Homo sapiens 47-81 32911202-7 2020 CONCLUSION: Patients treated with metformin and insulin combination had lower serum MCP-1 and cathepsin-D levels which suggests that this combination may be more effective in reducing the progression of diabetic retinopathy. Metformin 34-43 C-C motif chemokine ligand 2 Homo sapiens 84-89 32950474-6 2020 Furthermore, the levels of C-C motif ligand 2 (CCL2) mRNA and protein expression rose with the concentration and time increasing of Tp0136. tp0136 132-138 C-C motif chemokine ligand 2 Homo sapiens 27-45 32950474-6 2020 Furthermore, the levels of C-C motif ligand 2 (CCL2) mRNA and protein expression rose with the concentration and time increasing of Tp0136. tp0136 132-138 C-C motif chemokine ligand 2 Homo sapiens 47-51 32950474-8 2020 Further study revealed that, in cells pretreated with anti-fibronectin antibody, anti-integrin beta1 antibody or RGD (Arg-Gly-Asp), the expression levels of CCL2 induced by Tp0136 were notably decreased. arginyl-glycyl-aspartic acid 113-116 C-C motif chemokine ligand 2 Homo sapiens 157-161 32950474-8 2020 Further study revealed that, in cells pretreated with anti-fibronectin antibody, anti-integrin beta1 antibody or RGD (Arg-Gly-Asp), the expression levels of CCL2 induced by Tp0136 were notably decreased. arginyl-glycyl-aspartic acid 118-129 C-C motif chemokine ligand 2 Homo sapiens 157-161 32950474-8 2020 Further study revealed that, in cells pretreated with anti-fibronectin antibody, anti-integrin beta1 antibody or RGD (Arg-Gly-Asp), the expression levels of CCL2 induced by Tp0136 were notably decreased. tp0136 173-179 C-C motif chemokine ligand 2 Homo sapiens 157-161 32950474-10 2020 These results show that Tp0136 promots the migration of HMEC-1 cells by inducing CCL2 expression via the interaction of the fibronectin RGD domain with integrin beta1 and the CCL2/CCR2 signaling pathway, and these interactions may contribute to the mechanisms that increase the capacity for self-healing syphilis infection. tp0136 24-30 C-C motif chemokine ligand 2 Homo sapiens 81-85 32950474-10 2020 These results show that Tp0136 promots the migration of HMEC-1 cells by inducing CCL2 expression via the interaction of the fibronectin RGD domain with integrin beta1 and the CCL2/CCR2 signaling pathway, and these interactions may contribute to the mechanisms that increase the capacity for self-healing syphilis infection. tp0136 24-30 C-C motif chemokine ligand 2 Homo sapiens 175-179 33139635-0 2020 Empagliflozin Inhibits Basal and IL-1beta-Mediated MCP-1/CCL2 and Endothelin-1 Expression in Human Proximal Tubular Cells. empagliflozin 0-13 C-C motif chemokine ligand 2 Homo sapiens 57-61 33139635-6 2020 The co-administration of Empa inhibited IL-1beta-mediated MCP-1/CCL2 (0.2-fold, each) and ET-1 (0.2-fold, each) mRNA expression as early as 1 h after ligand stimulation and for at least 24 h in both HPTC lines, respectively. empagliflozin 25-29 C-C motif chemokine ligand 2 Homo sapiens 58-63 33139635-6 2020 The co-administration of Empa inhibited IL-1beta-mediated MCP-1/CCL2 (0.2-fold, each) and ET-1 (0.2-fold, each) mRNA expression as early as 1 h after ligand stimulation and for at least 24 h in both HPTC lines, respectively. empagliflozin 25-29 C-C motif chemokine ligand 2 Homo sapiens 64-68 33139635-7 2020 This inhibitory effect of Empa on basal and IL-1beta-mediated MCP-1/CCL2 and ET-1 mRNA expression was corroborated at the protein level. empagliflozin 26-30 C-C motif chemokine ligand 2 Homo sapiens 62-67 33139635-7 2020 This inhibitory effect of Empa on basal and IL-1beta-mediated MCP-1/CCL2 and ET-1 mRNA expression was corroborated at the protein level. empagliflozin 26-30 C-C motif chemokine ligand 2 Homo sapiens 68-72 32311699-12 2020 IMPACT: We found that decreases in the concentrations of MMP-2, bFGF, VEGF, and MCP-1 were associated with regression of the hemangioma, which indicates that one of the mechanisms of propranolol in the treatment of proliferative hemangiomas may involve downregulation of those cytokines.Patients with higher bFGF and VEGF levels showed better response to propranolol at 1 year. Propranolol 183-194 C-C motif chemokine ligand 2 Homo sapiens 80-85 32394976-7 2020 In the spinal cord, the muscovite nanoparticle injections exhibited inhibitory effects on astrocyte and microglia activation and reduced the expression of pro-inflammatory cytokines, such as interleukin-1beta, tumor necrosis factor-alpha, interleiukin-6 and monocyte chemoattractant protein-1, which were upregulated in the partial sciatic nerve ligation model. muscovite 24-33 C-C motif chemokine ligand 2 Homo sapiens 258-292 32956565-11 2020 CONCLUSIONS: Gefitinib-resistant cell lines have stronger proliferation and migration capabilities, and attract macrophages by releasing more CCL2 to reduce the sensitivity of cells to gefitinib. Gefitinib 13-22 C-C motif chemokine ligand 2 Homo sapiens 142-146 32920000-5 2020 Our results have demonstrated that lopinavir/ritonavir increased the expression of the genes involved in immune response and lipid metabolism (IL6, ICAM1, CCL2, TNF, APOA1, etc.). lopinavir-ritonavir drug combination 35-54 C-C motif chemokine ligand 2 Homo sapiens 155-159 32956565-11 2020 CONCLUSIONS: Gefitinib-resistant cell lines have stronger proliferation and migration capabilities, and attract macrophages by releasing more CCL2 to reduce the sensitivity of cells to gefitinib. Gefitinib 185-194 C-C motif chemokine ligand 2 Homo sapiens 142-146 32920000-6 2020 Chloroquine/hydroxychloroquine + azithromycin interacted with 6 genes (CCL2, CTSB, CXCL8, IL1B, IL6 and TNF), whereas chloroquine and azithromycin affected two additional genes (BCL2L1 and CYP3A4), which might be a reason behind a greater number of consequential diseases. Chloroquine 0-11 C-C motif chemokine ligand 2 Homo sapiens 71-75 32920000-6 2020 Chloroquine/hydroxychloroquine + azithromycin interacted with 6 genes (CCL2, CTSB, CXCL8, IL1B, IL6 and TNF), whereas chloroquine and azithromycin affected two additional genes (BCL2L1 and CYP3A4), which might be a reason behind a greater number of consequential diseases. Hydroxychloroquine 12-30 C-C motif chemokine ligand 2 Homo sapiens 71-75 32776108-13 2020 MCP-1 showed a significant linear decrease and also accounted for significant variance in alcohol craving, with higher levels associated with stronger craving. Alcohols 90-97 C-C motif chemokine ligand 2 Homo sapiens 0-5 32920000-6 2020 Chloroquine/hydroxychloroquine + azithromycin interacted with 6 genes (CCL2, CTSB, CXCL8, IL1B, IL6 and TNF), whereas chloroquine and azithromycin affected two additional genes (BCL2L1 and CYP3A4), which might be a reason behind a greater number of consequential diseases. Azithromycin 33-45 C-C motif chemokine ligand 2 Homo sapiens 71-75 32920000-6 2020 Chloroquine/hydroxychloroquine + azithromycin interacted with 6 genes (CCL2, CTSB, CXCL8, IL1B, IL6 and TNF), whereas chloroquine and azithromycin affected two additional genes (BCL2L1 and CYP3A4), which might be a reason behind a greater number of consequential diseases. Chloroquine 19-30 C-C motif chemokine ligand 2 Homo sapiens 71-75 33107041-12 2021 Therefore, the mRNA levels of MCP-1 and IL-8 in hPDLCs were significantly decreased through the vitamin D pathway. Vitamin D 96-105 C-C motif chemokine ligand 2 Homo sapiens 30-35 33140607-5 2020 However, pretreatment with Polyinosinic acid could significantly reduce the expression of MCP-1 compared with visfatin group. Poly I 27-44 C-C motif chemokine ligand 2 Homo sapiens 90-95 33105865-8 2020 The immune cell response after M-T7 treatment was associated with a retention of CCL2 levels, and increased abundances of arginase-1-expressing M2 macrophages and CD4 T cells. m-t7 31-35 C-C motif chemokine ligand 2 Homo sapiens 81-85 33135616-6 2021 RESULTS: B. animalis R101-8 inhibited LPS- and palmitic acid-induced protein expression of inflammatory cytokines IL-1beta, IL-6, TNF-alpha concomitant with decreases in chemerin, MCP-1, PEDF, and cellular triglycerides, and blocked NF-kB and AP-1 activation pathway through inhibition of p-IkappaBalpha, pc-Jun, and pc-Fos phosphorylation. Palmitic Acid 47-60 C-C motif chemokine ligand 2 Homo sapiens 180-185 33344897-6 2020 AGN 225660 inhibited RANTES, IL-8, and MCP-1 secretion by at least 50%, from TNFalpha activated human macrophages. agn 225660 0-10 C-C motif chemokine ligand 2 Homo sapiens 39-44 33344897-7 2020 Although AGN 225660 reduced TNFalpha-evoked MCP-1 release from human monocyte-derived macrophages, it increased LPS-induced MCP-1 secretion (up to 2-fold) from human monocyte-derived dendritic cells. agn 9-12 C-C motif chemokine ligand 2 Homo sapiens 44-49 33344897-7 2020 Although AGN 225660 reduced TNFalpha-evoked MCP-1 release from human monocyte-derived macrophages, it increased LPS-induced MCP-1 secretion (up to 2-fold) from human monocyte-derived dendritic cells. agn 9-12 C-C motif chemokine ligand 2 Homo sapiens 124-129 33114240-9 2020 One of the latter compounds-7,10-diisobutyryloxy-8,9-epoxythymyl isobutyrate-at concentrations 0.5, 1.0 and 2.5 muM, significantly reduced IL-8, IL-1beta and CCL2 excretion by LPS-stimulated human neutrophils. 7,10-diisobutyryloxy-8,9-epoxythymyl isobutyrate 28-76 C-C motif chemokine ligand 2 Homo sapiens 158-162 32776108-16 2020 Results also support further investigation into the role of MCP-1 in alcohol craving. Alcohols 69-76 C-C motif chemokine ligand 2 Homo sapiens 60-65 33107903-7 2020 Furthermore, fursultiamine suppressed LPS-induced upregulation of IL-6, IL-8, and monocyte chemoattractant protein-1 in a dose-dependent and time-dependent manner in primary hRPE cells. Fursultiamin 13-26 C-C motif chemokine ligand 2 Homo sapiens 82-116 33178053-7 2020 Among athletes who belong to different CD ranks, IL-1beta and monocyte chemoattractant protein-1(MCP1) levels were higher (p = 0.03) in the low CD-rank group compared with high CD counterpart, whereas, SOD levels were higher (p = 0.001) in high and moderate CD-rank groups compared to low counterpart. Cadmium 144-146 C-C motif chemokine ligand 2 Homo sapiens 97-101 33178053-7 2020 Among athletes who belong to different CD ranks, IL-1beta and monocyte chemoattractant protein-1(MCP1) levels were higher (p = 0.03) in the low CD-rank group compared with high CD counterpart, whereas, SOD levels were higher (p = 0.001) in high and moderate CD-rank groups compared to low counterpart. Cadmium 144-146 C-C motif chemokine ligand 2 Homo sapiens 97-101 32798558-8 2020 KEY FINDINGS: Results from humans showed that anesthesia with Dex decreased the number of both CD68 positive cells and CD86 positive cells and down-regulated level of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and monocyte chemotactic protein 1 (MCP-1) in human lung. Dexmedetomidine 62-65 C-C motif chemokine ligand 2 Homo sapiens 238-268 32798558-8 2020 KEY FINDINGS: Results from humans showed that anesthesia with Dex decreased the number of both CD68 positive cells and CD86 positive cells and down-regulated level of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and monocyte chemotactic protein 1 (MCP-1) in human lung. Dexmedetomidine 62-65 C-C motif chemokine ligand 2 Homo sapiens 270-275 32717406-7 2020 Furthermore, both minocycline and bindarit, a CCL-2 inhibitor, prevented apoptosis and electrophysiological dysfunction of Purkinje cells, the principal neurons and sole outputs of the cerebellar cortex, and consequently improved ataxia-like motor abnormalities. Minocycline 18-29 C-C motif chemokine ligand 2 Homo sapiens 46-51 32717406-7 2020 Furthermore, both minocycline and bindarit, a CCL-2 inhibitor, prevented apoptosis and electrophysiological dysfunction of Purkinje cells, the principal neurons and sole outputs of the cerebellar cortex, and consequently improved ataxia-like motor abnormalities. bindarit 34-42 C-C motif chemokine ligand 2 Homo sapiens 46-51 31302732-0 2020 Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid. Kynurenic Acid 76-90 C-C motif chemokine ligand 2 Homo sapiens 37-71 31302732-1 2020 Preclinical studies indicate a link between the kynurenine pathway and monocyte chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies examining this further. Kynurenine 48-58 C-C motif chemokine ligand 2 Homo sapiens 71-105 31302732-1 2020 Preclinical studies indicate a link between the kynurenine pathway and monocyte chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies examining this further. Kynurenine 48-58 C-C motif chemokine ligand 2 Homo sapiens 107-112 31302732-3 2020 We show an association between MCP-1 and kynurenic acid (KYNA), driven by unique environmental influences and a less pronounced association between MCP-1 and tryptophan. Kynurenic Acid 41-55 C-C motif chemokine ligand 2 Homo sapiens 31-36 32589777-8 2020 The concentration of CBM (12.5%) inhibited the production of IL-6 (p<0.05), IL-8 (p<0.01) and MCP-1 (p<0.005) and augmented the production of IL-10 (p<0.05). N-(4-chlorobenzoyl)melatonin 21-24 C-C motif chemokine ligand 2 Homo sapiens 94-99 32755990-11 2020 DHT pre-treatment significantly decreased IFNgamma-induced expression of HLA-DR, mRNA expression of iNOS, COX2 and MCP1, and secretion of IL1, IL2, IL5, IL6, MCP1 and GCSF. Dihydrotestosterone 0-3 C-C motif chemokine ligand 2 Homo sapiens 115-119 32755990-11 2020 DHT pre-treatment significantly decreased IFNgamma-induced expression of HLA-DR, mRNA expression of iNOS, COX2 and MCP1, and secretion of IL1, IL2, IL5, IL6, MCP1 and GCSF. Dihydrotestosterone 0-3 C-C motif chemokine ligand 2 Homo sapiens 158-162 32763585-2 2020 This study reports specifically on MCP-1 levels, as a potential marker of BDD and/or treatment response in patients receiving combination treatment with the cyclooxygenase-2 inhibitor, celecoxib (CBX). Celecoxib 185-194 C-C motif chemokine ligand 2 Homo sapiens 35-40 32763585-2 2020 This study reports specifically on MCP-1 levels, as a potential marker of BDD and/or treatment response in patients receiving combination treatment with the cyclooxygenase-2 inhibitor, celecoxib (CBX). cbx 196-199 C-C motif chemokine ligand 2 Homo sapiens 35-40 32763585-8 2020 Week 8 HAMD-17 scores and MCP-1 levels were significantly negatively correlated in treatment non-responders to CBX or PBO (P = 0.050). cbx 111-114 C-C motif chemokine ligand 2 Homo sapiens 26-31 32763585-10 2020 MCP-1 was positively correlated with pro-inflammatory analytes in the PBO group and with anti-inflammatory analytes in the CBX group. cbx 123-126 C-C motif chemokine ligand 2 Homo sapiens 0-5 32763585-13 2020 Since non-responders had lower levels of MCP-1, elevated MCP-1 may indicate a better response to CBX + SSRI treatment. cbx 97-100 C-C motif chemokine ligand 2 Homo sapiens 41-46 32763585-13 2020 Since non-responders had lower levels of MCP-1, elevated MCP-1 may indicate a better response to CBX + SSRI treatment. cbx 97-100 C-C motif chemokine ligand 2 Homo sapiens 57-62 32967076-5 2020 Patients treated with metformin showed decreased levels of all analyzed serum pro-inflammatory markers (TNFalpha, IL6, IL1beta and MCP1) and a downwards trend in IL18 levels associated with a lower production of oxidative stress markers in leukocytes (mitochondrial ROS and myeloperoxidase (MPO)). Metformin 22-31 C-C motif chemokine ligand 2 Homo sapiens 131-135 32898315-8 2020 Both GLA and PLA (50 muM) decreased production of soluble ICAM-1 (sICAM-1), MCP-1 and RANTES. gamma-Linolenic Acid 5-8 C-C motif chemokine ligand 2 Homo sapiens 76-81 32898315-10 2020 DGLA and ETA (10 muM) decreased EC production of sICAM-1, MCP-1, RANTES and IL-6. 8,11,14-Eicosatrienoic Acid 0-4 C-C motif chemokine ligand 2 Homo sapiens 58-63 33062929-1 2020 Purpose: The purpose of this study was to investigate the serum levels of malondialdehyde (MDA) which is a marker of oxidative stress, monocyte chemoattractant protein-1 (MCP-1) which has an important role in inflammation, and vitamin C which has antioxidant properties in patients with wet age-related macular degeneration (wAMD). Ascorbic Acid 227-236 C-C motif chemokine ligand 2 Homo sapiens 171-176 32927704-8 2020 The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha). Fatty Acids 12-22 C-C motif chemokine ligand 2 Homo sapiens 266-294 32948789-6 2020 The potently chemotactic chemokine CCL2 was induced by exosomes from a subgroup of patients, and in a blocking assay the exosome-induced CCL2 was reduced for 13 out of 19 patients by the asthma drug Montelukast, a cysteinyl leukotriene receptor antagonist. montelukast 199-210 C-C motif chemokine ligand 2 Homo sapiens 35-39 32948789-6 2020 The potently chemotactic chemokine CCL2 was induced by exosomes from a subgroup of patients, and in a blocking assay the exosome-induced CCL2 was reduced for 13 out of 19 patients by the asthma drug Montelukast, a cysteinyl leukotriene receptor antagonist. montelukast 199-210 C-C motif chemokine ligand 2 Homo sapiens 137-141 32948789-6 2020 The potently chemotactic chemokine CCL2 was induced by exosomes from a subgroup of patients, and in a blocking assay the exosome-induced CCL2 was reduced for 13 out of 19 patients by the asthma drug Montelukast, a cysteinyl leukotriene receptor antagonist. cysteinyl-leukotriene 214-235 C-C motif chemokine ligand 2 Homo sapiens 35-39 32948789-6 2020 The potently chemotactic chemokine CCL2 was induced by exosomes from a subgroup of patients, and in a blocking assay the exosome-induced CCL2 was reduced for 13 out of 19 patients by the asthma drug Montelukast, a cysteinyl leukotriene receptor antagonist. cysteinyl-leukotriene 214-235 C-C motif chemokine ligand 2 Homo sapiens 137-141 32948789-8 2020 These findings add to an emerging picture of exosomes as mediators and disseminators of inflammation, and open for further investigations of the link between CCL2 and exosomal leukotrienes in sarcoidosis. Leukotrienes 176-188 C-C motif chemokine ligand 2 Homo sapiens 158-162 32927704-8 2020 The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha). Fatty Acids 12-22 C-C motif chemokine ligand 2 Homo sapiens 296-300 32927704-8 2020 The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha). Prostaglandins 98-111 C-C motif chemokine ligand 2 Homo sapiens 266-294 32927704-8 2020 The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha). Prostaglandins 98-111 C-C motif chemokine ligand 2 Homo sapiens 296-300 32927704-8 2020 The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha). Dinoprostone 112-116 C-C motif chemokine ligand 2 Homo sapiens 266-294 32927704-8 2020 The altered fatty acid profile was associated with an increased synthesis of the pro-inflammatory prostaglandin PGE2, which correlated with the upregulation of numerous NFkB-dependent pro-inflammatory mediators, including interleukin-1 (IL-1), interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), and tumor necrosis factor-alpha (TNFalpha). Dinoprostone 112-116 C-C motif chemokine ligand 2 Homo sapiens 296-300 32782494-9 2020 However, pretreatment with curcumin increased the expression of ABCA1 and cholesterol efflux and suppressed secretion of TNF-alpha, MCP-1 and Il-6. Curcumin 27-35 C-C motif chemokine ligand 2 Homo sapiens 132-137 31624866-6 2020 Phenolic acid extracts contained in 10 mg biofortified bread downregulated the LPS-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 as well as pro-inflammatory cytokines TNF-alpha and IL-1beta, in endothelial cells and monocytes, with CXCL-10 as the most reduced inflammatory mediator. phenolic acid 0-13 C-C motif chemokine ligand 2 Homo sapiens 116-121 31912578-9 2020 Furthermore, emodin positively regulated TUG1 expression and TUG1 silencing could reverse the efficacy of emodin on IL-6 and MCP-1 expressions. Emodin 13-19 C-C motif chemokine ligand 2 Homo sapiens 125-130 31912578-9 2020 Furthermore, emodin positively regulated TUG1 expression and TUG1 silencing could reverse the efficacy of emodin on IL-6 and MCP-1 expressions. Emodin 106-112 C-C motif chemokine ligand 2 Homo sapiens 125-130 32753567-15 2020 In contrast, KR33426 decreased E-cadherin and TNF-alpha-enhanced CCL2. KR33426 13-20 C-C motif chemokine ligand 2 Homo sapiens 65-69 32753567-16 2020 Taken together, our results demonstrate that synovial cell migration via CCL2 expression could be regulated by BAFF expression which is decreased by KR33426 and c-Fos-siRNA. KR33426 149-156 C-C motif chemokine ligand 2 Homo sapiens 73-77 32782494-0 2020 Curcumin affects ox-LDL-induced IL-6, TNF-alpha, MCP-1 secretion and cholesterol efflux in THP-1 cells by suppressing the TLR4/NF-kappaB/miR33a signaling pathway. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 49-54 32726647-4 2020 OxLDL priming induced a proinflammatory memory with increased production of inflammatory cytokines such as IL-6, IL-8 and MCP-1 in response to PAM3cys4 restimulation. pam3cys4 143-151 C-C motif chemokine ligand 2 Homo sapiens 122-127 32645629-7 2020 We found that DMF significantly improved cell viability and reduced the expression of pro-inflammatory cytokines and chemokines, including IL-6, IL-8, and MCP-1. Dimethyl Fumarate 14-17 C-C motif chemokine ligand 2 Homo sapiens 155-160 32015430-6 2020 Mono-n-butyl phthalate (MBP) was correlated with higher IL-1beta, IL-6, and CRP expression in placentae of male fetuses and with higher IL-6, CRP, MCP-1, IL-8, IL-10, and CD68 expression in placentae of female fetuses. monobutyl phthalate 0-22 C-C motif chemokine ligand 2 Homo sapiens 147-152 32015430-6 2020 Mono-n-butyl phthalate (MBP) was correlated with higher IL-1beta, IL-6, and CRP expression in placentae of male fetuses and with higher IL-6, CRP, MCP-1, IL-8, IL-10, and CD68 expression in placentae of female fetuses. monobutyl phthalate 24-27 C-C motif chemokine ligand 2 Homo sapiens 147-152 32015430-7 2020 Mono benzyl phthalate (MBzP) increased the expression of TNF-alpha, MCP-1, and CD68 only in placentae of male fetuses. mono-benzyl phthalate 0-21 C-C motif chemokine ligand 2 Homo sapiens 68-73 32015430-7 2020 Mono benzyl phthalate (MBzP) increased the expression of TNF-alpha, MCP-1, and CD68 only in placentae of male fetuses. mono-benzyl phthalate 23-27 C-C motif chemokine ligand 2 Homo sapiens 68-73 32015430-8 2020 Mono (2-ethyl-5-oxohexyl) phthalate (MEOHP) was negatively correlated with CRP, MCP-1, and CD68 in placentae of female fetuses. mono(2-ethyl-5-oxohexyl)phthalate 0-35 C-C motif chemokine ligand 2 Homo sapiens 80-85 32767737-9 2020 Acute ACh treatment up-regulated monocyte chemoattractant protein 1 levels. Acetylcholine 6-9 C-C motif chemokine ligand 2 Homo sapiens 33-67 32713794-0 2020 Erratum to "CCL2/CCR2 Chemokine System in Embryonic Hypothalamus: Involvement in Sexually Dimorphic Stimulatory Effects of Prenatal Ethanol Exposure on Peptide-Expressing Neurons" [Neuroscience 424C (2020) 155-171]. Ethanol 132-139 C-C motif chemokine ligand 2 Homo sapiens 12-16 32923824-0 2020 Elucidating the Molecular Interactions of Chemokine CCL2 Orthologs with Flavonoid Baicalin. Flavonoids 72-81 C-C motif chemokine ligand 2 Homo sapiens 52-56 32923824-0 2020 Elucidating the Molecular Interactions of Chemokine CCL2 Orthologs with Flavonoid Baicalin. baicalin 82-90 C-C motif chemokine ligand 2 Homo sapiens 52-56 32923824-7 2020 In the current study, using an array of monomers/dimers of human and murine CCL2 orthologs (hCCL2/mCCL2), we have shown that BA binds to the CCL2 protein specifically with nanomolar affinity (K d = 270 +- 20 nM). baicalin 125-127 C-C motif chemokine ligand 2 Homo sapiens 92-97 32923824-10 2020 As the residues R18, R24, and K49 of hCCL2 are crucial determinants of monocyte trafficking through receptor/glycosaminoglycans (GAG) binding in CCL2 human/murine orthologs, we propose that baicalin engaging these residues in complex formation will result in attenuation of CCL2 binding to the receptor/GAGs, thus inhibiting the chemokine-regulated leukocyte trafficking. Glycosaminoglycans 109-127 C-C motif chemokine ligand 2 Homo sapiens 37-42 32923824-10 2020 As the residues R18, R24, and K49 of hCCL2 are crucial determinants of monocyte trafficking through receptor/glycosaminoglycans (GAG) binding in CCL2 human/murine orthologs, we propose that baicalin engaging these residues in complex formation will result in attenuation of CCL2 binding to the receptor/GAGs, thus inhibiting the chemokine-regulated leukocyte trafficking. Glycosaminoglycans 109-127 C-C motif chemokine ligand 2 Homo sapiens 38-42 32923824-10 2020 As the residues R18, R24, and K49 of hCCL2 are crucial determinants of monocyte trafficking through receptor/glycosaminoglycans (GAG) binding in CCL2 human/murine orthologs, we propose that baicalin engaging these residues in complex formation will result in attenuation of CCL2 binding to the receptor/GAGs, thus inhibiting the chemokine-regulated leukocyte trafficking. Glycosaminoglycans 129-132 C-C motif chemokine ligand 2 Homo sapiens 37-42 32786865-6 2020 Similarly, there was a significant reduction in chemokine MCP-1 from a positive control of 9.70 +- 0.52 ng/mL to 6.6 +- 0.43 ng/mL, after gamma-EV treatment. gamma-ev 138-146 C-C motif chemokine ligand 2 Homo sapiens 58-63 32923824-10 2020 As the residues R18, R24, and K49 of hCCL2 are crucial determinants of monocyte trafficking through receptor/glycosaminoglycans (GAG) binding in CCL2 human/murine orthologs, we propose that baicalin engaging these residues in complex formation will result in attenuation of CCL2 binding to the receptor/GAGs, thus inhibiting the chemokine-regulated leukocyte trafficking. Glycosaminoglycans 129-132 C-C motif chemokine ligand 2 Homo sapiens 38-42 32923824-10 2020 As the residues R18, R24, and K49 of hCCL2 are crucial determinants of monocyte trafficking through receptor/glycosaminoglycans (GAG) binding in CCL2 human/murine orthologs, we propose that baicalin engaging these residues in complex formation will result in attenuation of CCL2 binding to the receptor/GAGs, thus inhibiting the chemokine-regulated leukocyte trafficking. baicalin 190-198 C-C motif chemokine ligand 2 Homo sapiens 37-42 32923824-10 2020 As the residues R18, R24, and K49 of hCCL2 are crucial determinants of monocyte trafficking through receptor/glycosaminoglycans (GAG) binding in CCL2 human/murine orthologs, we propose that baicalin engaging these residues in complex formation will result in attenuation of CCL2 binding to the receptor/GAGs, thus inhibiting the chemokine-regulated leukocyte trafficking. baicalin 190-198 C-C motif chemokine ligand 2 Homo sapiens 38-42 33013356-12 2020 Ivacaftor increased plasma concentrations of CXCL2, a neutrophil chemokine secreted by monocytes and macrophages, and CCL2, a monocyte chemokine. ivacaftor 0-9 C-C motif chemokine ligand 2 Homo sapiens 118-122 32512068-4 2020 TAMs in IBC secrete high levels of the cytokines interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1/CCL2) compared to non-IBC patients. tams 0-4 C-C motif chemokine ligand 2 Homo sapiens 74-108 32512068-4 2020 TAMs in IBC secrete high levels of the cytokines interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1/CCL2) compared to non-IBC patients. tams 0-4 C-C motif chemokine ligand 2 Homo sapiens 110-115 32512068-4 2020 TAMs in IBC secrete high levels of the cytokines interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1/CCL2) compared to non-IBC patients. tams 0-4 C-C motif chemokine ligand 2 Homo sapiens 116-120 32512068-8 2020 Dasatinib, an inhibitor of p-Src, and U0126, an inhibitor of p-Erk1/2, down-regulated invasion and expression of CTSB by HCC70 and SUM149 cells, a mechanism that is reversed by IL-8 and MCP-1/CCL2. Dasatinib 0-9 C-C motif chemokine ligand 2 Homo sapiens 186-191 32512068-8 2020 Dasatinib, an inhibitor of p-Src, and U0126, an inhibitor of p-Erk1/2, down-regulated invasion and expression of CTSB by HCC70 and SUM149 cells, a mechanism that is reversed by IL-8 and MCP-1/CCL2. Dasatinib 0-9 C-C motif chemokine ligand 2 Homo sapiens 192-196 32512068-8 2020 Dasatinib, an inhibitor of p-Src, and U0126, an inhibitor of p-Erk1/2, down-regulated invasion and expression of CTSB by HCC70 and SUM149 cells, a mechanism that is reversed by IL-8 and MCP-1/CCL2. U 0126 38-43 C-C motif chemokine ligand 2 Homo sapiens 186-191 32512068-8 2020 Dasatinib, an inhibitor of p-Src, and U0126, an inhibitor of p-Erk1/2, down-regulated invasion and expression of CTSB by HCC70 and SUM149 cells, a mechanism that is reversed by IL-8 and MCP-1/CCL2. U 0126 38-43 C-C motif chemokine ligand 2 Homo sapiens 192-196 32922964-10 2020 Polymorphisms of the glucocorticoid receptor and variants of CCL2, YAP1, miR-21-5p and NF-kappabeta might be responsible for different responses to treatments used in keloid scars such as 5-fluorouracil. Fluorouracil 188-202 C-C motif chemokine ligand 2 Homo sapiens 61-65 32781843-6 2021 Furthermore, DDA and DTA showed strong anti-inflammatory effects in human macrophages differentiated from monocyte THP-1 cells through lowering the protein expression levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interferon gamma (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor alpha (TNF-alpha). dda 13-16 C-C motif chemokine ligand 2 Homo sapiens 286-320 32781843-6 2021 Furthermore, DDA and DTA showed strong anti-inflammatory effects in human macrophages differentiated from monocyte THP-1 cells through lowering the protein expression levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interferon gamma (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor alpha (TNF-alpha). diphtheria toxin fragment A 21-24 C-C motif chemokine ligand 2 Homo sapiens 286-320 32806763-12 2020 RIH/glucose fluctuations also induced M1 polarization and an inflammatory profile (CD11c, IL-1beta, TNF-alpha, IL-6, and monocyte chemoattractant protein (MCP)-1) in macrophages. Glucose 4-11 C-C motif chemokine ligand 2 Homo sapiens 121-161 32982316-11 2020 Additionally, we observed decreased mRNA expression of FN 1, LUM, BGN, MMP2, COL5A1, TIMP1 and CC-chemokines (CCL2, CCL5, CCL11) in response to 1,25(OH)2D3 addition to the TGF-beta1 or TNF-alpha-IL-1beta-stimulated HBFCs. Calcitriol 144-155 C-C motif chemokine ligand 2 Homo sapiens 110-114 32781843-6 2021 Furthermore, DDA and DTA showed strong anti-inflammatory effects in human macrophages differentiated from monocyte THP-1 cells through lowering the protein expression levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interferon gamma (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor alpha (TNF-alpha). diphtheria toxin fragment A 21-24 C-C motif chemokine ligand 2 Homo sapiens 322-327 32781843-6 2021 Furthermore, DDA and DTA showed strong anti-inflammatory effects in human macrophages differentiated from monocyte THP-1 cells through lowering the protein expression levels of pro-inflammatory cytokines interleukin-1beta (IL-1beta), interleukin-6 (IL-6), interferon gamma (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor alpha (TNF-alpha). dda 13-16 C-C motif chemokine ligand 2 Homo sapiens 322-327 32793908-8 2020 TMPRSS2, inflammatory cytokines G-CSF, M- CSF, IL-1a, IL-6 and MCP-1 are suppressed by MEKi alone or in combination with remdesivir. remdesivir 121-131 C-C motif chemokine ligand 2 Homo sapiens 63-68 32471866-9 2020 We show that a BK1.1 derivative, BK1.3, has substantially improved ability to disrupt P672 binding to CCL8, CCL2 and CCL3 in an AlphaScreen assay. 2-ETHYLHEXYL ACETATE 86-90 C-C motif chemokine ligand 2 Homo sapiens 108-112 32191339-0 2020 CCL2 mitigates cyclic AMP-suppressed Th2 immune response in human dendritic cells. Cyclic AMP 15-25 C-C motif chemokine ligand 2 Homo sapiens 0-4 32418888-5 2020 We discovered that PCCs secrete CCL3 and stimulate IL-6, CCL2, ICAM-1 and VCAM-1 expression in MSCs and that the MSC-PCC crosstalk can be disrupted by the lipid-lowering drug simvastatin, which displays pleiotropic effects on cell metabolism and suppresses IL-6 and CCL2 production by MSCs and CCL3 secretion by PCCs. pyridinium chlorochromate 19-22 C-C motif chemokine ligand 2 Homo sapiens 57-61 32686520-5 2020 Furthermore, extracellular ATP aggravates PA-induced monocyte chemoattractant protein-1 secretion and monocyte infiltration of tubular cells, enlarging the inflammatory response in both macrophages and HK-2 cells via the purinergic P2X7 receptor-mammalian target of rapamycin-forkhead box O1-thioredoxin-interacting protein/NOD-like receptor protein 3 inflammasome pathway. Adenosine Triphosphate 27-30 C-C motif chemokine ligand 2 Homo sapiens 53-87 32686520-5 2020 Furthermore, extracellular ATP aggravates PA-induced monocyte chemoattractant protein-1 secretion and monocyte infiltration of tubular cells, enlarging the inflammatory response in both macrophages and HK-2 cells via the purinergic P2X7 receptor-mammalian target of rapamycin-forkhead box O1-thioredoxin-interacting protein/NOD-like receptor protein 3 inflammasome pathway. Palmitic Acid 42-44 C-C motif chemokine ligand 2 Homo sapiens 53-87 32418888-5 2020 We discovered that PCCs secrete CCL3 and stimulate IL-6, CCL2, ICAM-1 and VCAM-1 expression in MSCs and that the MSC-PCC crosstalk can be disrupted by the lipid-lowering drug simvastatin, which displays pleiotropic effects on cell metabolism and suppresses IL-6 and CCL2 production by MSCs and CCL3 secretion by PCCs. pyridinium chlorochromate 19-22 C-C motif chemokine ligand 2 Homo sapiens 266-270 32430842-9 2020 Our data also revealed that CM-NP could significantly reduce the invasiveness of GSCs compared with CM, possibly via MCP-1-mediated pathways. cm-np 28-33 C-C motif chemokine ligand 2 Homo sapiens 117-122 32418888-5 2020 We discovered that PCCs secrete CCL3 and stimulate IL-6, CCL2, ICAM-1 and VCAM-1 expression in MSCs and that the MSC-PCC crosstalk can be disrupted by the lipid-lowering drug simvastatin, which displays pleiotropic effects on cell metabolism and suppresses IL-6 and CCL2 production by MSCs and CCL3 secretion by PCCs. Simvastatin 175-186 C-C motif chemokine ligand 2 Homo sapiens 57-61 32418888-5 2020 We discovered that PCCs secrete CCL3 and stimulate IL-6, CCL2, ICAM-1 and VCAM-1 expression in MSCs and that the MSC-PCC crosstalk can be disrupted by the lipid-lowering drug simvastatin, which displays pleiotropic effects on cell metabolism and suppresses IL-6 and CCL2 production by MSCs and CCL3 secretion by PCCs. Simvastatin 175-186 C-C motif chemokine ligand 2 Homo sapiens 266-270 32588186-10 2020 Namely, butyrate ameliorated the overproduction of adhesion molecules, including VCAM-1 and E-selectin, reduced oxidative stress by reducing the levels of ROS and 4-HNE, and suppressed inflammation via inhibition of MCP-1 and IL-8. Butyrates 8-16 C-C motif chemokine ligand 2 Homo sapiens 216-221 32627003-0 2020 Molecular mechanism of gossypol mediating CCL2 and IL-8 attenuation in triple-negative breast cancer cells. Gossypol 23-31 C-C motif chemokine ligand 2 Homo sapiens 42-46 32430842-9 2020 Our data also revealed that CM-NP could significantly reduce the invasiveness of GSCs compared with CM, possibly via MCP-1-mediated pathways. Curcumin 28-30 C-C motif chemokine ligand 2 Homo sapiens 117-122 32733952-9 2020 Hepatic glutathione peroxidase 1 and monocyte chemotactic protein 1 genes expression of piglets was upregulated by oral resveratrol administration. Resveratrol 120-131 C-C motif chemokine ligand 2 Homo sapiens 37-67 32747750-4 2020 Protein array analysis revealed hepatocyte growth factor (HGF) and C-C motif chemokine 2 (CCL2) were significantly upregulated in non-PB-ATLs compared with PB-ATLs. Lead 134-136 C-C motif chemokine ligand 2 Homo sapiens 90-94 32747750-4 2020 Protein array analysis revealed hepatocyte growth factor (HGF) and C-C motif chemokine 2 (CCL2) were significantly upregulated in non-PB-ATLs compared with PB-ATLs. Lead 156-158 C-C motif chemokine ligand 2 Homo sapiens 90-94 32802141-8 2020 Shikonin significantly inhibited Der p 2-induced expression of interleukin (IL)-6, IL-9, and IL-17A; monocyte chemoattractant protein (MCP)-1; macrophage inflammatory protein (MIP)-1alpha; MIP-1beta; and Chemokine (C-C motif) ligand 5 (RANTES). shikonin 0-8 C-C motif chemokine ligand 2 Homo sapiens 101-141 32793635-9 2020 On the other hand, patients with AF using rivaroxaban presented increased levels of the chemokines (MCP-1 in comparison with warfarin users; MIG and IP-10 in comparison with controls). Rivaroxaban 42-53 C-C motif chemokine ligand 2 Homo sapiens 100-105 32802081-13 2020 Captopril increased IL-8 from stroke-Mo and increased IL-6, IL-8, and MCP-1 secretions from MSCs. Captopril 0-9 C-C motif chemokine ligand 2 Homo sapiens 70-75 32802081-15 2020 Atenolol increased the secretion of IL-8 and MCP-1 while captopril increased the secretion of IL-6 and MCP-1 from MSCs. Atenolol 0-8 C-C motif chemokine ligand 2 Homo sapiens 45-50 32802081-15 2020 Atenolol increased the secretion of IL-8 and MCP-1 while captopril increased the secretion of IL-6 and MCP-1 from MSCs. Captopril 57-66 C-C motif chemokine ligand 2 Homo sapiens 103-108 32802081-17 2020 Losartan reduced MCP-1 and TNF-alpha from stroke-Mo and reduced IL-8 from cocultures of stroke-Mo and MSCs. Losartan 0-8 C-C motif chemokine ligand 2 Homo sapiens 17-22 32562599-5 2020 Upon RPM depletion, red pulp fibroblasts transiently produced the monocyte chemoattractants CCL2 and CCL7, thereby contributing to the replenishment of the RPM network. Sirolimus 5-8 C-C motif chemokine ligand 2 Homo sapiens 92-96 32678310-0 2021 Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties. bindarit 22-30 C-C motif chemokine ligand 2 Homo sapiens 14-18 32678310-3 2021 In this study, we found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltration of periodontal tissues were closely related to DP. dp 168-170 C-C motif chemokine ligand 2 Homo sapiens 51-55 32678310-4 2021 Moreover, inhibition of CCL2 by oral administration of bindarit reduced alveolar bone loss and increased periodontal epithelial thickness by suppressing periodontal inflammation. bindarit 55-63 C-C motif chemokine ligand 2 Homo sapiens 24-28 32562599-5 2020 Upon RPM depletion, red pulp fibroblasts transiently produced the monocyte chemoattractants CCL2 and CCL7, thereby contributing to the replenishment of the RPM network. Sirolimus 156-159 C-C motif chemokine ligand 2 Homo sapiens 92-96 32238729-4 2020 Administration of steroid and high-dose intravenous immunoglobulin (1 g/kg) did not alleviate fever or reduce cytokine production; however, after administration of etoposide (an antineoplastic agent), fever decreased immediately, the patient"s general condition improved, and levels of IL-6, IL-10, IL-8, MCP-1, IFN-gamma, and TNF-alpha declined after etoposide administration. Etoposide 164-173 C-C motif chemokine ligand 2 Homo sapiens 305-310 32485058-6 2020 Paclitaxel induced overexpression of C-C motif chemokine ligand 2 (CCL2), tumour necrosis alpha (TNFalpha) and interleukin-6 (IL-6) in DRGs, where the presence of macrophages was demonstrated. Paclitaxel 0-10 C-C motif chemokine ligand 2 Homo sapiens 37-65 32653013-11 2020 CCL2 was significantly increased in CPEB3 knockdown cells, while CCL2 antibody treatment rescued the effect of CPEB3 knockdown in promoting CD163+ TAM polarization. tam 147-150 C-C motif chemokine ligand 2 Homo sapiens 65-69 32510220-8 2020 However, concentrations of PFOS and 6:2 Cl-PFESA were both significantly and positively associated with MCP-1 levels, while PFOA was inversely associated with IL-8. perfluorooctane sulfonic acid 27-31 C-C motif chemokine ligand 2 Homo sapiens 104-109 32510220-8 2020 However, concentrations of PFOS and 6:2 Cl-PFESA were both significantly and positively associated with MCP-1 levels, while PFOA was inversely associated with IL-8. cl-pfesa 40-48 C-C motif chemokine ligand 2 Homo sapiens 104-109 32663289-6 2020 In addition, pretreatment of OFs with thiophenecarboxamide (TPCA-1) inhibits retinoid-induced MCP-1 induction, suggesting an NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells)-dependent mechanism. 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide 60-66 C-C motif chemokine ligand 2 Homo sapiens 94-99 32663289-6 2020 In addition, pretreatment of OFs with thiophenecarboxamide (TPCA-1) inhibits retinoid-induced MCP-1 induction, suggesting an NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells)-dependent mechanism. Retinoids 77-85 C-C motif chemokine ligand 2 Homo sapiens 94-99 32663289-7 2020 We also found that treatment with cholecalciferol (vitamin D3) mitigates MCP-1 induction, likely because of competition between retinoic acid receptors (RARs) and vitamin D receptors (VDR) for their common binding partner retinoid nuclear receptors (RXRs). Cholecalciferol 34-49 C-C motif chemokine ligand 2 Homo sapiens 73-78 32663289-7 2020 We also found that treatment with cholecalciferol (vitamin D3) mitigates MCP-1 induction, likely because of competition between retinoic acid receptors (RARs) and vitamin D receptors (VDR) for their common binding partner retinoid nuclear receptors (RXRs). Cholecalciferol 51-61 C-C motif chemokine ligand 2 Homo sapiens 73-78 32154764-0 2020 Puerarin inhibits the migration of osteoclast precursors and osteoclastogenesis by inhibiting MCP-1 production. puerarin 0-8 C-C motif chemokine ligand 2 Homo sapiens 94-99 32154764-3 2020 The results showed that puerarin reduced MCP-1 production in OCPs, while inhibiting OCPs migration based on MCP-1. puerarin 24-32 C-C motif chemokine ligand 2 Homo sapiens 41-46 32154764-3 2020 The results showed that puerarin reduced MCP-1 production in OCPs, while inhibiting OCPs migration based on MCP-1. puerarin 24-32 C-C motif chemokine ligand 2 Homo sapiens 108-113 32154764-4 2020 Puerarin reversed MCP-1-promoted osteoclastogenesis. puerarin 0-8 C-C motif chemokine ligand 2 Homo sapiens 18-23 32154764-6 2020 Therefore, puerarin prevents OCPs migration by reducing MCP-1, whereby inhibiting osteoclastogenesis. puerarin 11-19 C-C motif chemokine ligand 2 Homo sapiens 56-61 32167157-7 2020 CB1 deficiency enhanced the repeated APAP-induced increases in alphaSMA and cleaved Caspase3, and blocked those of Cyp2e1, TNFalpha, the chemokine MCP1, and the circulating transaminase gammaGT. Acetaminophen 37-41 C-C motif chemokine ligand 2 Homo sapiens 147-151 32167157-8 2020 Although JWH015 reduced the expression of alphaSMA and TNFalpha in acute APAP, ACEA increased the expression of cleaved Caspase3 and MCP1 in repeated APAP. arachidonyl-2-chloroethylamide 79-83 C-C motif chemokine ligand 2 Homo sapiens 133-137 32371379-7 2020 H19 relieved miR-1-3p-induced inhibition of CCL2 expression by acting as a ceRNA. mir-1-3p 13-21 C-C motif chemokine ligand 2 Homo sapiens 44-48 32663289-0 2020 Retinoic Acid Potentiates Orbital Tissues for Inflammation Through NF-kappaB and MCP-1. Tretinoin 0-13 C-C motif chemokine ligand 2 Homo sapiens 81-86 32663289-5 2020 Results: Both normal and TED patient-derived OFs display robust induction of monocyte chemoattractant protein 1 (MCP-1) upon retinoid treatment; TED OFs secrete significantly more MCP-1 than normal OFs. Retinoids 125-133 C-C motif chemokine ligand 2 Homo sapiens 77-111 32663289-5 2020 Results: Both normal and TED patient-derived OFs display robust induction of monocyte chemoattractant protein 1 (MCP-1) upon retinoid treatment; TED OFs secrete significantly more MCP-1 than normal OFs. Retinoids 125-133 C-C motif chemokine ligand 2 Homo sapiens 113-118 32663289-6 2020 In addition, pretreatment of OFs with thiophenecarboxamide (TPCA-1) inhibits retinoid-induced MCP-1 induction, suggesting an NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells)-dependent mechanism. thiophenecarboxamide 38-58 C-C motif chemokine ligand 2 Homo sapiens 94-99 32818222-7 2020 Urine netrin-1/Cr was positively correlated with MCP-1/CCL-2/Cr (r = 0.356, p = 0.045). Creatinine 15-17 C-C motif chemokine ligand 2 Homo sapiens 49-54 32818222-7 2020 Urine netrin-1/Cr was positively correlated with MCP-1/CCL-2/Cr (r = 0.356, p = 0.045). Creatinine 15-17 C-C motif chemokine ligand 2 Homo sapiens 55-60 32485058-6 2020 Paclitaxel induced overexpression of C-C motif chemokine ligand 2 (CCL2), tumour necrosis alpha (TNFalpha) and interleukin-6 (IL-6) in DRGs, where the presence of macrophages was demonstrated. Paclitaxel 0-10 C-C motif chemokine ligand 2 Homo sapiens 67-71 32570911-6 2020 RESULTS: Our data showed that ZnO was able to reduce the inflammatory response of DECs, in terms of vascular cell adhesion molecule-1 (VCAM-1), interleukin (IL)-8, IL-6, tumor necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1) expression induced by TNF-alpha stimulation. Zinc Oxide 30-33 C-C motif chemokine ligand 2 Homo sapiens 214-248 32484349-5 2020 Ouratein D (4) inhibited in vitro the release of the pro-inflammatory cytokine CCL2 by lipopolysaccharide-stimulated THP-1 cells (IC50 of 3.1 +- 1.1 muM), whereas TNF and IL-1beta release were not reduced by any of the biflavanones. ouratein d 0-10 C-C motif chemokine ligand 2 Homo sapiens 79-83 32484349-6 2020 These findings show ouratein D (4) as a selective CCL2 inhibitor, which may have potential for the development of new anti-inflammatory agents to prevent or treat cardiovascular diseases. ouratein d (4 20-33 C-C motif chemokine ligand 2 Homo sapiens 50-54 32377746-8 2020 It was also demonstrated that DHMEQ exposure significantly decreased the levels of interleukin (IL)-8 and monocyte chemoattractant protein-1 (MCP-1) in the supernatant of cultured ARPE-19 cells as determined by ELISA. dehydroxymethylepoxyquinomicin 30-35 C-C motif chemokine ligand 2 Homo sapiens 106-140 32377746-8 2020 It was also demonstrated that DHMEQ exposure significantly decreased the levels of interleukin (IL)-8 and monocyte chemoattractant protein-1 (MCP-1) in the supernatant of cultured ARPE-19 cells as determined by ELISA. dehydroxymethylepoxyquinomicin 30-35 C-C motif chemokine ligand 2 Homo sapiens 142-147 32377746-9 2020 Moreover, the protein expression levels of IL-8 and MCP-1 were significantly reduced in ARPE-19 cells exposed to DHMEQ compared with cells exposed to dexamethasone. dehydroxymethylepoxyquinomicin 113-118 C-C motif chemokine ligand 2 Homo sapiens 52-57 32685503-9 2020 Using isotretinoin for 1 week, LCN2, PTGES, and GDF15 were upregulated and might mediate sebocytes apoptosis and thus decreased sebum production; CCL2 originated from activated TNF signaling pathway and S100A7 could be related with "acne-flare". Isotretinoin 6-18 C-C motif chemokine ligand 2 Homo sapiens 146-150 32570911-6 2020 RESULTS: Our data showed that ZnO was able to reduce the inflammatory response of DECs, in terms of vascular cell adhesion molecule-1 (VCAM-1), interleukin (IL)-8, IL-6, tumor necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1) expression induced by TNF-alpha stimulation. Zinc Oxide 30-33 C-C motif chemokine ligand 2 Homo sapiens 250-255 31610228-8 2020 Patients with alcohol overconsumption had higher levels of IL-6 (p = 0.002), IFN-gamma (p = 0.018) and MCP-1 (p = 0.006), and lower levels of TGF-beta1 (p = 0.017) compared with control patients. Ethanol 14-21 C-C motif chemokine ligand 2 Homo sapiens 103-108 32536965-14 2020 Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2). kaempferol 107-117 C-C motif chemokine ligand 2 Homo sapiens 221-225 32536965-14 2020 Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2). Quercetin 119-128 C-C motif chemokine ligand 2 Homo sapiens 221-225 32536965-14 2020 Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2). 7-methoxy-2-methyl isoflavone 130-159 C-C motif chemokine ligand 2 Homo sapiens 221-225 32536965-14 2020 Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2). naringenin 161-171 C-C motif chemokine ligand 2 Homo sapiens 221-225 32536965-14 2020 Second, the molecular docking results showed that there was a certain affinity between the core compounds (kaempferol, quercetin, 7-Methoxy-2-methyl isoflavone, naringenin, formononetin) and core target genes (IL6, IL1B, CCL2). formononetin 173-185 C-C motif chemokine ligand 2 Homo sapiens 221-225 31610228-12 2020 CONCLUSION: Patients with alcohol overconsumption had a cytokine profile suggestive of increased systemic inflammatory activity, with higher levels of pro-inflammatory cytokines (IL-6, IFN-gamma and MCP-1) and lower levels of anti-inflammatory cytokines (TGF-beta1). Ethanol 26-33 C-C motif chemokine ligand 2 Homo sapiens 199-204 32606862-9 2020 In vitro, the mRNA expression of MCP-1 and TNF-alpha was significantly decreased when the generation of alpha1-AT in tubular epithelial cells was inhibited under high glucose stimulation. Glucose 167-174 C-C motif chemokine ligand 2 Homo sapiens 33-38 31736269-9 2020 CONCLUSION: The dexamethasone implant affected the aqueous cytokines and proteins MCP-1, sICAM-1, sVCAM-1 and MIG, whereas ranibizumab treatments reduced VEGF and PIGF levels. Dexamethasone 16-29 C-C motif chemokine ligand 2 Homo sapiens 82-87 32391982-4 2020 By using non-hydrolyzable analogues of pyrophosphate, the reagent can be readily modified to obtain a family of non-hydrolyzable analogues containing CH2 , CF2 , CCl2 , and NH that are stable in solution for several weeks if stored appropriately. diphosphoric acid 39-52 C-C motif chemokine ligand 2 Homo sapiens 162-166 31840936-12 2020 Metformin or AICAR presence decreased spontaneous production of IL-6, IL-8 and MCP-1 in RA synovial explants and SFCs (n=5-7). Metformin 0-9 C-C motif chemokine ligand 2 Homo sapiens 79-84 31840936-12 2020 Metformin or AICAR presence decreased spontaneous production of IL-6, IL-8 and MCP-1 in RA synovial explants and SFCs (n=5-7). AICA ribonucleotide 13-18 C-C motif chemokine ligand 2 Homo sapiens 79-84 32200039-5 2020 The chemokine expression of CXCL1, CXCL2, and CCL2 increased in cisplatin-resistant cells compared to those in their parent strains. Cisplatin 64-73 C-C motif chemokine ligand 2 Homo sapiens 46-50 32572902-12 2020 On the contrary, Sirt1 downregulation by Nico aggravated the phosphorylation of c-Fos/c-Jun and MCP-1 expression. Niacinamide 41-45 C-C motif chemokine ligand 2 Homo sapiens 96-101 32695293-10 2020 The secretion of MCP-1 and TGF-beta1 were higher in hDPSCs treated with Biodentine compared to some other groups (P<0.05, P<0.01). tricalcium silicate 72-82 C-C motif chemokine ligand 2 Homo sapiens 17-22 32058033-9 2020 EPA and DHA also significantly lowered production of monocyte chemoattractant protein 1, interleukin (IL)-6 and IL-8. Eicosapentaenoic Acid 0-3 C-C motif chemokine ligand 2 Homo sapiens 53-87 32058033-9 2020 EPA and DHA also significantly lowered production of monocyte chemoattractant protein 1, interleukin (IL)-6 and IL-8. Docosahexaenoic Acids 8-11 C-C motif chemokine ligand 2 Homo sapiens 53-87 32221618-7 2020 Co-stimulation with poly I:C and LL-37 enhanced pro-inflammatory IL-6 and MCP-1 transcripts several fold compared to treatment with poly I:C or LL-37 alone. Poly I-C 20-28 C-C motif chemokine ligand 2 Homo sapiens 74-79 32221618-8 2020 Poly I:C increased IL-6 and MCP-1 protein production, and this effect was potentiated by LL-37. Poly I-C 0-8 C-C motif chemokine ligand 2 Homo sapiens 28-33 32064734-3 2020 The results showed that BCP and beta-TCP could support macrophages attachment, proliferation and spreading favorably, as well as promote gene expressions of inflammatory related cytokines (IL-1, IL-6, MCP-1 and TNF-alpha) and growth factors (TGF-beta, FGF, PDGF, VEGF, IGF and EGF). 3-benzyl-6-chloro-2-pyrone 24-27 C-C motif chemokine ligand 2 Homo sapiens 201-206 32064734-3 2020 The results showed that BCP and beta-TCP could support macrophages attachment, proliferation and spreading favorably, as well as promote gene expressions of inflammatory related cytokines (IL-1, IL-6, MCP-1 and TNF-alpha) and growth factors (TGF-beta, FGF, PDGF, VEGF, IGF and EGF). beta-tricalcium phosphate 32-40 C-C motif chemokine ligand 2 Homo sapiens 201-206 31802418-12 2020 Treatment with RK-33 inhibits the Tat and cocaine-dependent increase in the number and size of microglia and the proinflammatory cytokines IL-6, TNF-alpha, MCP-1/CCL2, MIP-2, IL-1alpha and IL-1beta. Cocaine 42-49 C-C motif chemokine ligand 2 Homo sapiens 156-161 32374474-5 2020 In the present study, silvestrol down-regulated several pro- and anti-inflammatory cytokines (IL-6, IL-8, IL-10, CCL2, CCL18) and increased TNF-alpha during differentiation and activation of M1-macrophages, suggesting that the effects of silvestrol might cancel each other out. silvestrol 22-32 C-C motif chemokine ligand 2 Homo sapiens 113-117 32374474-6 2020 However, silvestrol amplified the anti-inflammatory potential of M2-macrophages by increasing expression of anti-inflammatory surface markers CD206, TREM2 and reducing release of pro-inflammatory IL-8 and CCL2. silvestrol 9-19 C-C motif chemokine ligand 2 Homo sapiens 205-209 31802418-12 2020 Treatment with RK-33 inhibits the Tat and cocaine-dependent increase in the number and size of microglia and the proinflammatory cytokines IL-6, TNF-alpha, MCP-1/CCL2, MIP-2, IL-1alpha and IL-1beta. Cocaine 42-49 C-C motif chemokine ligand 2 Homo sapiens 162-166 32801436-10 2020 TMZ and EECP therapy in patients with stable refractory angina remarkably decreased the inflammatory markers HSP60, MCP-1 and IL-1beta in serum levels also the decreased levels were found in serum levels of oxidative stress marker 8-iso-PGF2beta serum level. Trimetazidine 0-3 C-C motif chemokine ligand 2 Homo sapiens 116-121 32801436-10 2020 TMZ and EECP therapy in patients with stable refractory angina remarkably decreased the inflammatory markers HSP60, MCP-1 and IL-1beta in serum levels also the decreased levels were found in serum levels of oxidative stress marker 8-iso-PGF2beta serum level. eecp 8-12 C-C motif chemokine ligand 2 Homo sapiens 116-121 32330017-4 2020 The selected cyclic sulfopeptides possess high affinity for the target chemokine (as well as one or more of the related family members CCL2, CCL7 and CCL24) and inhibit CCL11 activation of CC chemokine receptor 3 (CCR3). cyclic sulfopeptides 13-33 C-C motif chemokine ligand 2 Homo sapiens 135-139 32219433-10 2020 Treatment with PFOS, PFOA, and GenX also decreased trophoblast expression of chemokines (e.g. CCL2), chemokine receptors (e.g. CCR4), and inflammatory enzymes (e.g. ALOX15) involved in migration. perfluorooctane sulfonic acid 15-19 C-C motif chemokine ligand 2 Homo sapiens 94-98 32219433-10 2020 Treatment with PFOS, PFOA, and GenX also decreased trophoblast expression of chemokines (e.g. CCL2), chemokine receptors (e.g. CCR4), and inflammatory enzymes (e.g. ALOX15) involved in migration. perfluorooctanoic acid 21-25 C-C motif chemokine ligand 2 Homo sapiens 94-98 32219433-10 2020 Treatment with PFOS, PFOA, and GenX also decreased trophoblast expression of chemokines (e.g. CCL2), chemokine receptors (e.g. CCR4), and inflammatory enzymes (e.g. ALOX15) involved in migration. perfluorooctane 31-35 C-C motif chemokine ligand 2 Homo sapiens 94-98 32333962-7 2020 The SCFA mixture, as well as several individual SCFAs at the highest concentrations used in the mixture (15-236 muM), decreased the secretion of interleukin (IL)-1beta, monocyte chemoattractant protein (MCP)-1, tumor necrosis factor (TNF)-alpha, and cytotoxins by immune-stimulated THP-1 cells. Fatty Acids, Volatile 4-8 C-C motif chemokine ligand 2 Homo sapiens 169-209 32333962-7 2020 The SCFA mixture, as well as several individual SCFAs at the highest concentrations used in the mixture (15-236 muM), decreased the secretion of interleukin (IL)-1beta, monocyte chemoattractant protein (MCP)-1, tumor necrosis factor (TNF)-alpha, and cytotoxins by immune-stimulated THP-1 cells. Fatty Acids, Volatile 48-53 C-C motif chemokine ligand 2 Homo sapiens 169-209 32455851-5 2020 PARP1 knockdown and PJ34 mediated inhibition showed reduced CCL2 transcript levels in breast cancer cells, corroborating the findings from the sequencing data. N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride 20-24 C-C motif chemokine ligand 2 Homo sapiens 60-64 31960917-6 2020 Pre-treating ARPE-19 cells with quercetin clearly attenuated high glucose-induced viability loss, apoptosis, MCP-1 and IL-6 overproduction, and ROS generation. Quercetin 32-41 C-C motif chemokine ligand 2 Homo sapiens 109-114 32429318-7 2020 Positive CCL2 staining in TCs was associated with shorter overall survival (OS), disease-specific survival (DSS), and relapse-free survival (RFS) (p = 0.004, p = 0.036, and p = 0.047; log rank test) and appeared to be an independent prognostic factor for OS (RR = 1.70; p = 0.007; multivariate Cox"s regression analysis). 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide 26-29 C-C motif chemokine ligand 2 Homo sapiens 9-13 32429318-8 2020 In contrast, positive CCL2 staining in the ICs was associated with longer OS, DSS, and RFS (p = 0.032, p = 0.001, and p = 0.001; log rank test) and appeared to be an independent prognostic factor for DSS (RR = 1.77; p = 0.031; multivariate Cox"s regression analysis). dss 78-81 C-C motif chemokine ligand 2 Homo sapiens 22-26 32429318-8 2020 In contrast, positive CCL2 staining in the ICs was associated with longer OS, DSS, and RFS (p = 0.032, p = 0.001, and p = 0.001; log rank test) and appeared to be an independent prognostic factor for DSS (RR = 1.77; p = 0.031; multivariate Cox"s regression analysis). dss 200-203 C-C motif chemokine ligand 2 Homo sapiens 22-26 32429318-11 2020 In summary, CCL2 positivity in TCs is a negative prognostic factor for OS, and CCL2 can mark ICs that are differentially associated with prognosis depending on the nodal stage of BCa patients. 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide 31-34 C-C motif chemokine ligand 2 Homo sapiens 12-16 32429318-12 2020 Therefore, CCL2 staining of TCs and ICs is suggested as a prognostic biomarker for BCa patients. 9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide 28-31 C-C motif chemokine ligand 2 Homo sapiens 11-15 32370749-10 2020 Meanwhile, sinensetin treatment significantly decreased IAV-induced expression of pro-inflammatory mediators at mRNA and protein levels, including IL-6, TNF-alpha, IP-10, IL-8 and MCP-1. sinensetin 11-21 C-C motif chemokine ligand 2 Homo sapiens 180-185 32431691-5 2020 We extended these findings to human Mphi THP-1 cells and showed that ATRA synergistically increased IL-4-induced CCL2, CCL13, and CCL26 mRNA and protein levels. Tretinoin 69-73 C-C motif chemokine ligand 2 Homo sapiens 113-117 32420479-5 2020 Lauric acid (LA) typically increased the mRNA expression of glial-derived neurotrophic factor (Gdnf), interleukin-6 (Il6), and C-C motif chemokine 2 (Ccl2) in astrocytes. lauric acid 0-11 C-C motif chemokine ligand 2 Homo sapiens 127-148 32420479-5 2020 Lauric acid (LA) typically increased the mRNA expression of glial-derived neurotrophic factor (Gdnf), interleukin-6 (Il6), and C-C motif chemokine 2 (Ccl2) in astrocytes. lauric acid 0-11 C-C motif chemokine ligand 2 Homo sapiens 150-154 32088177-7 2020 BDMC also significantly reduced the expression of intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) proteins, as well as the expression and translocation of the p65 subunit of nuclear factor-kappaB (NF-kappaB p65) into the nucleus, all of which were increased in the kidney by cisplatin treatment. bisdemethoxycurcumin 0-4 C-C motif chemokine ligand 2 Homo sapiens 97-131 32088177-7 2020 BDMC also significantly reduced the expression of intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) proteins, as well as the expression and translocation of the p65 subunit of nuclear factor-kappaB (NF-kappaB p65) into the nucleus, all of which were increased in the kidney by cisplatin treatment. bisdemethoxycurcumin 0-4 C-C motif chemokine ligand 2 Homo sapiens 133-138 32370011-5 2020 In the present study, CDDO-Me ameliorated monocyte infiltration without vasogenic edema formation in the frontoparietal cortex (FPC) following SE, accompanied by abrogating monocyte chemotactic protein-1 (MCP-1)/tumor necrosis factor-alpha (TNF-alpha) expressions and p38 mitogen-activated protein kinase (p38 MAPK) phosphorylation. bardoxolone methyl 22-29 C-C motif chemokine ligand 2 Homo sapiens 173-203 32370011-5 2020 In the present study, CDDO-Me ameliorated monocyte infiltration without vasogenic edema formation in the frontoparietal cortex (FPC) following SE, accompanied by abrogating monocyte chemotactic protein-1 (MCP-1)/tumor necrosis factor-alpha (TNF-alpha) expressions and p38 mitogen-activated protein kinase (p38 MAPK) phosphorylation. bardoxolone methyl 22-29 C-C motif chemokine ligand 2 Homo sapiens 205-210 32370011-8 2020 Therefore, these findings suggest, for the first time, that CDDO-Me may attenuate microglia/monocyte-mediated neuroinflammation via modulating NFkappaB- and p38 MAPK-MCP-1 signaling pathways following SE. bardoxolone methyl 60-67 C-C motif chemokine ligand 2 Homo sapiens 166-171 31960917-6 2020 Pre-treating ARPE-19 cells with quercetin clearly attenuated high glucose-induced viability loss, apoptosis, MCP-1 and IL-6 overproduction, and ROS generation. Glucose 66-73 C-C motif chemokine ligand 2 Homo sapiens 109-114 32370059-6 2020 Only patients in the MCP-1-high group had a significantly altered cytokine profile in the FF, and had a significantly higher serum estradiol level (p = 0.002) and a significantly lower number of oocytes recovered (p = 0.01) compared to the MCP-1-low and the control group. Estradiol 131-140 C-C motif chemokine ligand 2 Homo sapiens 21-26 32440094-6 2020 Methods: The effects of laquinimod on the gene expression of IL-6, MCP-1, VCAM-1, E-selectin, and KLF2 were measured by real-time PCR. laquinimod 24-34 C-C motif chemokine ligand 2 Homo sapiens 67-72 31896762-7 2020 DMPA-cytokine associations frequently differed by vaginal microbiome; in non-Lactobacillus-dominant women, DMPA was associated with elevated IL-8, MCP-1, and IP-10 concentrations. N,N-dimethyl-4-anisidine 0-4 C-C motif chemokine ligand 2 Homo sapiens 147-152 31896762-7 2020 DMPA-cytokine associations frequently differed by vaginal microbiome; in non-Lactobacillus-dominant women, DMPA was associated with elevated IL-8, MCP-1, and IP-10 concentrations. N,N-dimethyl-4-anisidine 107-111 C-C motif chemokine ligand 2 Homo sapiens 147-152 32091964-8 2020 Decrease of reactive oxygen species (ROS) level downregulated MCP-1 expression; in turn, rhMCP-1 promoted the generation of ROS. Reactive Oxygen Species 12-35 C-C motif chemokine ligand 2 Homo sapiens 62-67 32091964-8 2020 Decrease of reactive oxygen species (ROS) level downregulated MCP-1 expression; in turn, rhMCP-1 promoted the generation of ROS. Reactive Oxygen Species 37-40 C-C motif chemokine ligand 2 Homo sapiens 62-67 31796217-8 2020 Interleukin 1beta, monocyte chemoattractant protein 1, and IL-6 messenger RNA expression were considerably downregulated in the small intestine of the GAL group. galactomannan 151-154 C-C motif chemokine ligand 2 Homo sapiens 19-53 31796217-9 2020 In addition, GAL treatment significantly prevented plasma interleukin 6 and monocyte chemoattractant protein 1 upregulation and diminished nitrate and nitrite levels after 3 h of intestinal reperfusion. galactomannan 13-16 C-C motif chemokine ligand 2 Homo sapiens 76-110 32440094-10 2020 Results: Our findings demonstrate that laquinimod reduced the expression of key inflammatory cytokines and chemokines, including IL-6, MCP-1, and HMGB1. laquinimod 39-49 C-C motif chemokine ligand 2 Homo sapiens 135-140 32293313-0 2020 Urinary monocyte chemoattractant protein 1 associated with calcium oxalate crystallization in patients with primary hyperoxaluria. Calcium Oxalate 59-74 C-C motif chemokine ligand 2 Homo sapiens 8-42 32410856-6 2020 In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator. Carotenoids 28-39 C-C motif chemokine ligand 2 Homo sapiens 146-151 32410856-6 2020 In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator. Beta-Cryptoxanthin 47-65 C-C motif chemokine ligand 2 Homo sapiens 146-151 32410856-6 2020 In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator. Lutein 67-73 C-C motif chemokine ligand 2 Homo sapiens 146-151 32410856-6 2020 In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator. Lycopene 79-87 C-C motif chemokine ligand 2 Homo sapiens 146-151 32410856-6 2020 In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator. Fructose 104-112 C-C motif chemokine ligand 2 Homo sapiens 146-151 32313211-6 2021 Further, glutamate had extensive effects on gene expression in the mast cells, including the upregulation of pro-inflammatory components such as IL-6 and CCL2. Glutamic Acid 9-18 C-C motif chemokine ligand 2 Homo sapiens 154-158 32344494-10 2020 Urine MCP-1 was negatively correlated with eGFR (r=-0.303, P=0.012), but positively correlated with the urinary ratio of albumin to creatinin (r=0.368, P=0.002). creatinin 132-141 C-C motif chemokine ligand 2 Homo sapiens 6-11 32344494-12 2020 EGF/MCP-1 ratio was positively correlated with eGFR (r=0.693, P<0.001), but negatively correlated with the severity of the urinary ratio of albumin to creatinin and IFTA (r=-0.261, P=0.028 and r=-0.684, P<0.001, respectively). creatinin 151-160 C-C motif chemokine ligand 2 Homo sapiens 4-9 32344494-12 2020 EGF/MCP-1 ratio was positively correlated with eGFR (r=0.693, P<0.001), but negatively correlated with the severity of the urinary ratio of albumin to creatinin and IFTA (r=-0.261, P=0.028 and r=-0.684, P<0.001, respectively). ifta 165-169 C-C motif chemokine ligand 2 Homo sapiens 4-9 32344494-13 2020 Further multivariate logistic regression analysis showed that EGF/MCP-1 was a protective factor for moderate-to-severe IFTA (OR=0.891, 95%CI: 0.844-0.949, P=0.008). ifta 119-123 C-C motif chemokine ligand 2 Homo sapiens 66-71 32322697-1 2020 Objectives: To evaluate effectiveness of a nasal resveratrol/carboxymethyl-beta-glucan solution compared to nasal saline solution: a) on common cold symptoms by means of a validated measure scale (CARIFS score), b) on Rhinovirus infection and CCL2, CCL5, IL8, IL6, CXCL10 and TLR2 expression in nasal swabs, c) on frequency of relapses after 30 days of follow-up. Resveratrol 49-60 C-C motif chemokine ligand 2 Homo sapiens 243-247 32062076-6 2020 Besides, Cap attenuated APAP-induced overproduction and release of proinflammatory mediators like TNF-alpha, IL-1beta, IL-17A, IL-6, and MCP-1. cap 9-12 C-C motif chemokine ligand 2 Homo sapiens 137-142 32283652-8 2020 GLAP-aptamer bound to glycer-AGEs with a dissociation constant of 7.7 x 10-5 M. GLAP-aptamer, glycer-AGE-aptamer, or antibodies directed against receptor for glycer-AGEs (RAGE) completely prevented glycer-AGE- or GLAP-induced increase in ROS generation, MCP-1, PAI-1, or RAGE gene expression in tubular cells. glap 0-4 C-C motif chemokine ligand 2 Homo sapiens 254-259 32264868-8 2020 EMPA and DAPA (100 muM) significantly reduced SA-induced inflammation (IL1beta, TNFalpha, MCP1), oxidant stress (SOD2, TXN, HO1), but not apoptosis in MAC. empagliflozin 0-4 C-C motif chemokine ligand 2 Homo sapiens 90-94 32264868-8 2020 EMPA and DAPA (100 muM) significantly reduced SA-induced inflammation (IL1beta, TNFalpha, MCP1), oxidant stress (SOD2, TXN, HO1), but not apoptosis in MAC. dapagliflozin 9-13 C-C motif chemokine ligand 2 Homo sapiens 90-94 32264868-8 2020 EMPA and DAPA (100 muM) significantly reduced SA-induced inflammation (IL1beta, TNFalpha, MCP1), oxidant stress (SOD2, TXN, HO1), but not apoptosis in MAC. stearic acid 46-48 C-C motif chemokine ligand 2 Homo sapiens 90-94 32290603-4 2020 The results demonstrated that KC dose-dependently suppressed the production of inflammatory mediators, including NO, PGE2, IL-6, IL1beta, MCP-1, and IFN-beta in LPS-stimulated RAW264.7 macrophages. lysylcysteine 30-32 C-C motif chemokine ligand 2 Homo sapiens 138-143 32000013-7 2020 At the same time, the induction of TNFalpha and IL-1beta was diminished by the Ca2+/calmodulin-dependent protein kinase inhibitor, whereas the induction of IL-6 and CCL-2 was reduced by the inhibitor of phosphoinositide 3-kinase. Calcium 79-83 C-C motif chemokine ligand 2 Homo sapiens 165-170 32062076-6 2020 Besides, Cap attenuated APAP-induced overproduction and release of proinflammatory mediators like TNF-alpha, IL-1beta, IL-17A, IL-6, and MCP-1. Acetaminophen 24-28 C-C motif chemokine ligand 2 Homo sapiens 137-142 32179814-7 2020 Besides, melatonin prevented the positive actions that docetaxel exerts on the expression of other factors related to angiogenesis like JAG1, ANPEP, IGF-1, CXCL6, AKT1, ERK1, ERK2, MMP14 and NOS3 and neutralized the stimulating actions of vinorelbine on the expression of FIGF, FGFR3, CXCL6, CCL2, ERK1, ERK2, AKT1, NOS3 and MMP14. Melatonin 9-18 C-C motif chemokine ligand 2 Homo sapiens 292-296 32244804-6 2020 In brief, RB inactivation in several types of cancer cells enhances production of pro-inflammatory cytokines, including CCL2, through upregulation of mitochondrial reactive oxygen species (ROS) production. Reactive Oxygen Species 164-187 C-C motif chemokine ligand 2 Homo sapiens 120-124 32244804-6 2020 In brief, RB inactivation in several types of cancer cells enhances production of pro-inflammatory cytokines, including CCL2, through upregulation of mitochondrial reactive oxygen species (ROS) production. Reactive Oxygen Species 189-192 C-C motif chemokine ligand 2 Homo sapiens 120-124 31909645-5 2020 The expression of pro-inflammatory cytokines in the lung tissue, including TNF-alpha and MCP-1, was markedly increased by treatment with In2O3 NPs. Indium oxide (In2O3) 137-142 C-C motif chemokine ligand 2 Homo sapiens 89-94 31909645-8 2020 Real-time PCR analysis of the aorta showed that IL-6 and MCP-1 expression was up-regulated upon treatment with In2O3 NPs. Indium oxide (In2O3) 111-116 C-C motif chemokine ligand 2 Homo sapiens 57-62 31782556-5 2020 The dextran sulfate plasma adsorption system reduced IFN-gamma, IL-8, IL-1ra, eotaxin, TNF, MCP-1, PDGF-BB, MIP-1beta, and IP-10 (P < .05). Sulfates 12-19 C-C motif chemokine ligand 2 Homo sapiens 92-97 32198221-8 2020 Stromal CCL2 modulates both monocyte accumulation and ROS production, and is regulated, in part, by manipulations that modulate vascular permeability. Reactive Oxygen Species 54-57 C-C motif chemokine ligand 2 Homo sapiens 8-12 32179814-7 2020 Besides, melatonin prevented the positive actions that docetaxel exerts on the expression of other factors related to angiogenesis like JAG1, ANPEP, IGF-1, CXCL6, AKT1, ERK1, ERK2, MMP14 and NOS3 and neutralized the stimulating actions of vinorelbine on the expression of FIGF, FGFR3, CXCL6, CCL2, ERK1, ERK2, AKT1, NOS3 and MMP14. Docetaxel 55-64 C-C motif chemokine ligand 2 Homo sapiens 292-296 31794890-5 2020 We observed that SchA accelerated cell proliferation, prohibited apoptosis, and restrained pro-inflammatory cytokines (monocyte chemoattractant protein-1 [MCP-1], interleukin-6 [IL-6], and tumor necrosis factor alpha [TNF-alpha]) and reactive oxygen species (ROS) level in HG-stimulated cells. schizandrin A 17-21 C-C motif chemokine ligand 2 Homo sapiens 119-153 31930970-3 2020 In primary cultured bone marrow-derived macrophages (BMDMs), SalB attenuated lipopolysaccharide (LPS)-induced M1 biomarkers (IL-6, iNOS, CCL2 and TNF-alpha) mRNA expression in a concentration-dependent manner. salvianolic acid B 61-65 C-C motif chemokine ligand 2 Homo sapiens 137-141 32196098-6 2020 Results: Treatment with noncytotoxic concentrations of GS resulted in the dose-dependent inhibition of IL-1beta-induced inflammatory cytokines, including IL-6, IL-8, MCP-1, and COX-2, at both mRNA and protein levels. pregna-4,17-diene-3,16-dione 55-57 C-C motif chemokine ligand 2 Homo sapiens 166-171 32256661-7 2020 TCM treatment promoted the expression of CCL2 and CCL3 while it downregulated the CCL22 level among A549, H1975, and PC9 cells. tcm 0-3 C-C motif chemokine ligand 2 Homo sapiens 41-45 32168763-6 2020 The irreversible inhibitor of TG2 NC9 not only decreased reactive oxygen species production 28-fold, but decreased the concentration of MCP-1, IL-1beta and TNF-alpha 8-, 15- and 61-fold, respectively in the combined ATRA + ATO-treated wild-type NB4 cell culture. Tretinoin 216-220 C-C motif chemokine ligand 2 Homo sapiens 136-141 32168763-6 2020 The irreversible inhibitor of TG2 NC9 not only decreased reactive oxygen species production 28-fold, but decreased the concentration of MCP-1, IL-1beta and TNF-alpha 8-, 15- and 61-fold, respectively in the combined ATRA + ATO-treated wild-type NB4 cell culture. Arsenic Trioxide 223-226 C-C motif chemokine ligand 2 Homo sapiens 136-141 31794890-5 2020 We observed that SchA accelerated cell proliferation, prohibited apoptosis, and restrained pro-inflammatory cytokines (monocyte chemoattractant protein-1 [MCP-1], interleukin-6 [IL-6], and tumor necrosis factor alpha [TNF-alpha]) and reactive oxygen species (ROS) level in HG-stimulated cells. schizandrin A 17-21 C-C motif chemokine ligand 2 Homo sapiens 155-160 31972501-11 2020 Likewise, we also discovered that increasing CCL2 levels and decreasing selenium levels were associated with high CAS. cas 114-117 C-C motif chemokine ligand 2 Homo sapiens 45-49 31943636-0 2020 Phase I dose-escalation trial to repurpose propagermanium, an oral CCL2 inhibitor, in patients with breast cancer. propagermanium 43-57 C-C motif chemokine ligand 2 Homo sapiens 67-71 32147075-11 2020 Moreover, serum concentrations of TNF-alpha (p = 0.024), MCP-1 (p = 0.008) and EGF (p = 0.0001) were improved by curcuminoids in NAFLD patients. Diarylheptanoids 113-125 C-C motif chemokine ligand 2 Homo sapiens 57-62 32146317-7 2020 Theobromine also suppresses IL-1beta-induced production of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1), as well as matrix metalloproteinases (MMP)-3 and MMP-13. Theobromine 0-11 C-C motif chemokine ligand 2 Homo sapiens 134-168 32146317-7 2020 Theobromine also suppresses IL-1beta-induced production of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1), as well as matrix metalloproteinases (MMP)-3 and MMP-13. Theobromine 0-11 C-C motif chemokine ligand 2 Homo sapiens 170-175 32150886-7 2020 The release of IL-1beta, IL-8, MCP-1 and M-CSF proteins was mainly affected in macrophages after metal ion exposure (100 microM), indicating a higher impact on pro-inflammatory activity. Metals 97-102 C-C motif chemokine ligand 2 Homo sapiens 31-36 32135490-8 2020 Pristimerin dramatically inhibited the expression of TNF-alpha-induced endothelial adhesion molecules (intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1)) and the pro-inflammatory cytokine (IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1)). pristimerin 0-11 C-C motif chemokine ligand 2 Homo sapiens 244-278 32135490-8 2020 Pristimerin dramatically inhibited the expression of TNF-alpha-induced endothelial adhesion molecules (intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1)) and the pro-inflammatory cytokine (IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1)). pristimerin 0-11 C-C motif chemokine ligand 2 Homo sapiens 280-285 31962250-4 2020 BmV at 50 and 75 microg/mL reduced CXCL8/IL-8 (p < 0.001 and p < 0.01, respectively) and CCL2/MCP-1 production (p < 0.05), while BmooLAAO-I at the same concentrations reduced only CCL2/MCP-1 production (p < 0.01). 7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine 0-3 C-C motif chemokine ligand 2 Homo sapiens 89-93 31864122-5 2020 CML up-regulated both the gene expression of RAGE, the activating protein-1 (AP-1), the inflammatory cytokines Interleukin-6 (IL-6), vascular cell adhesion molecule1 (VCAM-1), monocyte chemotactic protein1 (MCP-1). Nepsilon-Dansyl-L-lysine 0-3 C-C motif chemokine ligand 2 Homo sapiens 176-205 31864122-5 2020 CML up-regulated both the gene expression of RAGE, the activating protein-1 (AP-1), the inflammatory cytokines Interleukin-6 (IL-6), vascular cell adhesion molecule1 (VCAM-1), monocyte chemotactic protein1 (MCP-1). Nepsilon-Dansyl-L-lysine 0-3 C-C motif chemokine ligand 2 Homo sapiens 207-212 31991371-5 2020 The results of our study show that tricetin suppressed oxidized low-density lipoprotein (ox-LDL)-induced expression of pro-inflammatory monocyte chemotactic protein-1 (MCP-1) and interleukin-1beta (IL-1beta), as well as the generation of reactive oxygen species (ROS). tricetin 35-43 C-C motif chemokine ligand 2 Homo sapiens 136-166 31962250-4 2020 BmV at 50 and 75 microg/mL reduced CXCL8/IL-8 (p < 0.001 and p < 0.01, respectively) and CCL2/MCP-1 production (p < 0.05), while BmooLAAO-I at the same concentrations reduced only CCL2/MCP-1 production (p < 0.01). 7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine 0-3 C-C motif chemokine ligand 2 Homo sapiens 94-99 31991371-5 2020 The results of our study show that tricetin suppressed oxidized low-density lipoprotein (ox-LDL)-induced expression of pro-inflammatory monocyte chemotactic protein-1 (MCP-1) and interleukin-1beta (IL-1beta), as well as the generation of reactive oxygen species (ROS). tricetin 35-43 C-C motif chemokine ligand 2 Homo sapiens 168-173 31962250-4 2020 BmV at 50 and 75 microg/mL reduced CXCL8/IL-8 (p < 0.001 and p < 0.01, respectively) and CCL2/MCP-1 production (p < 0.05), while BmooLAAO-I at the same concentrations reduced only CCL2/MCP-1 production (p < 0.01). 7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine 0-3 C-C motif chemokine ligand 2 Homo sapiens 180-184 31962250-4 2020 BmV at 50 and 75 microg/mL reduced CXCL8/IL-8 (p < 0.001 and p < 0.01, respectively) and CCL2/MCP-1 production (p < 0.05), while BmooLAAO-I at the same concentrations reduced only CCL2/MCP-1 production (p < 0.01). 7-cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine 0-3 C-C motif chemokine ligand 2 Homo sapiens 185-190 33318863-10 2021 H2S has also been shown to promote adipogenesis, inhibit lipolysis, and regulate adiponectin and MCP-1 secretion from adipocytes. Deuterium 0-3 C-C motif chemokine ligand 2 Homo sapiens 97-102 32281329-6 2020 Arachidonic acid(AA) metabolic pathway is principally used to synthesize inflammatory cytokines, such as monocyte chemotactic protein 1(MCP-1), tumor necrosis factor(TNF), IL, IFN, etc., which is closely related to the occurrence, development and regression of inflammation. Arachidonic Acid 0-16 C-C motif chemokine ligand 2 Homo sapiens 105-135 32281329-6 2020 Arachidonic acid(AA) metabolic pathway is principally used to synthesize inflammatory cytokines, such as monocyte chemotactic protein 1(MCP-1), tumor necrosis factor(TNF), IL, IFN, etc., which is closely related to the occurrence, development and regression of inflammation. Arachidonic Acid 0-16 C-C motif chemokine ligand 2 Homo sapiens 136-141 32103760-11 2020 Animal studies show blockade of CCL2-CCR2 axis strongly reduces tumor incidence by hindering TAMs recruitment and thereby potentiates the antitumor efficacy of CD8+ T cells in the tumor microenvironment. tams 93-97 C-C motif chemokine ligand 2 Homo sapiens 32-36 32153409-7 2020 Simvastatin (10 muM) treatment significantly reduced the monocyte chemoattractant protein 1 (MCP-1)-induced monocyte migration. Simvastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 57-91 32017913-6 2020 Additionally, Phoenixin-20 suppressed LPS-induced release of pro-inflammatory cytokines and inflammatory mediators, including IL-6, MCP-1, VCAM-1, and ICAM-1, as well as MMP-2 and MMP-9. phoenixin-20 14-26 C-C motif chemokine ligand 2 Homo sapiens 132-137 31724666-7 2020 Compared to DiDBV2 without iron oxide activation, DiDBV2-Fe indicated strong tumor tropism in response to monocyte chemoattractant protein-1 (CCL2) secreted by U87MG tumor cells. 4-(4-dihexadecylaminostyryl)-N-methylpyridium 12-18 C-C motif chemokine ligand 2 Homo sapiens 106-140 31724666-7 2020 Compared to DiDBV2 without iron oxide activation, DiDBV2-Fe indicated strong tumor tropism in response to monocyte chemoattractant protein-1 (CCL2) secreted by U87MG tumor cells. 4-(4-dihexadecylaminostyryl)-N-methylpyridium 12-18 C-C motif chemokine ligand 2 Homo sapiens 142-146 31724666-7 2020 Compared to DiDBV2 without iron oxide activation, DiDBV2-Fe indicated strong tumor tropism in response to monocyte chemoattractant protein-1 (CCL2) secreted by U87MG tumor cells. Iron 50-59 C-C motif chemokine ligand 2 Homo sapiens 106-140 31724666-7 2020 Compared to DiDBV2 without iron oxide activation, DiDBV2-Fe indicated strong tumor tropism in response to monocyte chemoattractant protein-1 (CCL2) secreted by U87MG tumor cells. Iron 50-59 C-C motif chemokine ligand 2 Homo sapiens 142-146 32153409-7 2020 Simvastatin (10 muM) treatment significantly reduced the monocyte chemoattractant protein 1 (MCP-1)-induced monocyte migration. Simvastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 93-98 32019805-8 2020 However, macrophages showed a significantly reduced amount of CXCL1 (KC) and CCL2 (MCP-1) secretion in CEACAM-humanized versus wt cells. ceacam 103-109 C-C motif chemokine ligand 2 Homo sapiens 77-81 32050980-5 2020 RESULTS: In this study, we report that clozapine treatment reduced the infiltration of peripheral immune cells into the central nervous system (CNS) and that this correlated with reduced expression of the chemokines CCL2 and CCL5 transcripts in the brain and spinal cord. Clozapine 39-48 C-C motif chemokine ligand 2 Homo sapiens 216-220 32057253-3 2020 The levels of cytokine and chemokine were analysed with ELISA and real-time PCR.Results: Astragaloside IV significantly inhibited the levels of CCL5, MCP-1, IL-6 and IL-8. astragaloside A 89-102 C-C motif chemokine ligand 2 Homo sapiens 150-155 32019805-8 2020 However, macrophages showed a significantly reduced amount of CXCL1 (KC) and CCL2 (MCP-1) secretion in CEACAM-humanized versus wt cells. ceacam 103-109 C-C motif chemokine ligand 2 Homo sapiens 83-88 32195015-5 2020 The formation and secretion of TAMs with M2 phenotypic characteristics, such as HIF-1alpha, and TNF-alpha, affect the progress of cancer cells by interfering with the secretion of MCP-1 by CAAs. tams 31-35 C-C motif chemokine ligand 2 Homo sapiens 180-185 32140070-8 2020 We first report the connection between Wnt5a/CaMKII/ERK/CCL2 axis and biological functions of TAMs in tumor microenvironment, indicating that Wnt5a may be a novel therapeutic target for CRC. tams 94-98 C-C motif chemokine ligand 2 Homo sapiens 56-60 31760088-4 2020 Exposure of MCF-7 cells to 17ss-estradiol stimulated cell proliferation and the expression of pro-metastatic and pro-invasive elements such as claudin-1, matrix metalloproteinase 9 (MMP9), and the CC chemokine ligand 2 (CCL2). Estradiol 32-41 C-C motif chemokine ligand 2 Homo sapiens 197-218 31760088-4 2020 Exposure of MCF-7 cells to 17ss-estradiol stimulated cell proliferation and the expression of pro-metastatic and pro-invasive elements such as claudin-1, matrix metalloproteinase 9 (MMP9), and the CC chemokine ligand 2 (CCL2). Estradiol 32-41 C-C motif chemokine ligand 2 Homo sapiens 220-224 31631328-6 2020 Moreover, it was observed that nicotine decreases the production of interleukin (IL)-6 and C-C chemokine ligand (CCL)5 during Mtb infection in epithelial cells (EpCs), whereas in macrophages derived from human monocytes (MDMs) there is a decrease in IL-8, IL-6, tumor necrosis factor (TNF)-alpha, IL-10, CCL2, C-X-C chemokine ligand (CXCL)9 and CXCL10 only during infection with Mtb. Nicotine 31-39 C-C motif chemokine ligand 2 Homo sapiens 304-308 31776047-7 2020 Melatonin levels after lunch were correlated with CCL2/MCP-1 (p = 4.2e-4), CCL3/MPI-1alpha (p = 6.5e-4) and VEGF-A (p = 5.3e-6). Melatonin 0-9 C-C motif chemokine ligand 2 Homo sapiens 50-54 31651714-6 2020 In this study, we demonstrate that mangiferin interferes with inflammation, lipid and calcium signaling which selectively inhibits multiple NFkB target genes including interleukin-6, tumor necrosis factor, interferon gamma, vascular endothelial growth factor receptor 2, plasminogen activator urokinase, matrix metalloprotease 19, C-C Motif Chemokine Ligand 2 and placental growth factor. mangiferin 35-45 C-C motif chemokine ligand 2 Homo sapiens 304-359 31776047-7 2020 Melatonin levels after lunch were correlated with CCL2/MCP-1 (p = 4.2e-4), CCL3/MPI-1alpha (p = 6.5e-4) and VEGF-A (p = 5.3e-6). Melatonin 0-9 C-C motif chemokine ligand 2 Homo sapiens 55-60 32076422-5 2020 Morphine-exposure of RM-PBMCs infected with SHIVs 4NF-kappaB, 3NF-kappaB, and AD8EO altered cellular transcript levels of monocyte chemoattractant protein 1, interleukin 6, interleukin 1beta, and Tumor Necrosis Factor alpha. Morphine 0-8 C-C motif chemokine ligand 2 Homo sapiens 122-156 31947962-5 2020 Local intravaginal delivery of curcumin nanoparticles, but not intraperitoneal or oral delivery, reduced CpG-mediated inflammatory histopathology and decreased production of pro-inflammatory cytokines Interleukin (IL)-6, Tumor Necrosis Factor Alpha (TNF-alpha) and Monocyte Chemoattractant Protein-1 (MCP-1) in the FGT. Curcumin 31-39 C-C motif chemokine ligand 2 Homo sapiens 265-299 31924826-9 2020 Supplementation of 25-vitamin D was able to reduce the expression of TRL4, cathelicidin, and MCP-1 in the uremic environment. Vitamin D 19-31 C-C motif chemokine ligand 2 Homo sapiens 93-98 31947962-5 2020 Local intravaginal delivery of curcumin nanoparticles, but not intraperitoneal or oral delivery, reduced CpG-mediated inflammatory histopathology and decreased production of pro-inflammatory cytokines Interleukin (IL)-6, Tumor Necrosis Factor Alpha (TNF-alpha) and Monocyte Chemoattractant Protein-1 (MCP-1) in the FGT. Curcumin 31-39 C-C motif chemokine ligand 2 Homo sapiens 301-306 31734849-10 2020 Arsenic could also trigger the induction of GATA4-NF-kappaB signaling and senescence-associated secretory phenotype (SASP) by increasing IL-1alpha, IL-1beta, TGF-beta, TNF-alpha, CCL2, PAI-1, and MMP13 mRNA expression. Arsenic 0-7 C-C motif chemokine ligand 2 Homo sapiens 179-183 31455510-6 2020 Levels of interleukin (IL)-6, IL-8, and macrophage chemotactic protein 1 (MCP-1) in the cerebrospinal fluid were high at onset and reduced transiently after steroid pulse therapy. Steroids 157-164 C-C motif chemokine ligand 2 Homo sapiens 40-72 31455510-6 2020 Levels of interleukin (IL)-6, IL-8, and macrophage chemotactic protein 1 (MCP-1) in the cerebrospinal fluid were high at onset and reduced transiently after steroid pulse therapy. Steroids 157-164 C-C motif chemokine ligand 2 Homo sapiens 74-79 31710162-8 2020 CCL2 immunohistochemistry was performed on pathological sections from 100 patients with invasive estrogen receptor-positive breast cancer. Estrogens 97-105 C-C motif chemokine ligand 2 Homo sapiens 0-4 31557637-7 2020 RESULTS: A significant association was observed between CCL2 levels and dyslipidemia (P = 0.029), even after adjustment for possible confounding variables, such as age, gender, body mass index, diabetes mellitus, HD time, urea pre-hemodialysis and interdialytic weight gain (P = 0.045). Urea 222-226 C-C motif chemokine ligand 2 Homo sapiens 56-60 32878466-9 2020 During islet infusion, serum cytokine (IL-6, IL-8, and MCP-1) levels and plasma hsa-miR-375 levels were lower in the CAA group than in the NAA group, but not significantly. caa 117-120 C-C motif chemokine ligand 2 Homo sapiens 55-60 31914700-2 2020 Recent evidence has demonstrated that CCL2 is involved in the blood-brain barrier (BBB) disruption and propagermanium (PG) as a CCL2 receptor inhibitor is neuroprotective in ischemic stroke. propagermanium 103-117 C-C motif chemokine ligand 2 Homo sapiens 128-132 31442679-7 2020 In the correlation analysis, albumin/creatinine ratio was significantly and positively correlated with IP-10/CXCL10, MCP-1/CCL2, MIG/CXCL9, IL-8/CXCL8, TNF, IL-10, and IL-6. Creatinine 37-47 C-C motif chemokine ligand 2 Homo sapiens 117-122 31442679-7 2020 In the correlation analysis, albumin/creatinine ratio was significantly and positively correlated with IP-10/CXCL10, MCP-1/CCL2, MIG/CXCL9, IL-8/CXCL8, TNF, IL-10, and IL-6. Creatinine 37-47 C-C motif chemokine ligand 2 Homo sapiens 123-127 31914700-2 2020 Recent evidence has demonstrated that CCL2 is involved in the blood-brain barrier (BBB) disruption and propagermanium (PG) as a CCL2 receptor inhibitor is neuroprotective in ischemic stroke. propagermanium 119-121 C-C motif chemokine ligand 2 Homo sapiens 128-132 31914700-11 2020 To the best of our knowledge, this is the first demonstration of PG in neuroprotecting the BBB integrity by inhibition of CCL2-CCR2-p38 MAPK pathway following ICH, targeting CCL2 could be developed as a novel treatment for hemorrhagic stroke. propagermanium 65-67 C-C motif chemokine ligand 2 Homo sapiens 122-126 31914700-11 2020 To the best of our knowledge, this is the first demonstration of PG in neuroprotecting the BBB integrity by inhibition of CCL2-CCR2-p38 MAPK pathway following ICH, targeting CCL2 could be developed as a novel treatment for hemorrhagic stroke. propagermanium 65-67 C-C motif chemokine ligand 2 Homo sapiens 174-178 31753516-11 2020 More importantly, metformin inhibited LPS-enhanced CCL-2 synthesis through modulation of the iNOS/NO pathway. Metformin 18-27 C-C motif chemokine ligand 2 Homo sapiens 51-56 31680470-3 2020 (R)-salbutamol significantly inhibited LPS-induced M1 macrophage polarization and downregulated expressions of typical M1 macrophage cytokines, including monocyte chemotactic protein-1 (MCP-1), interleukin-1beta (IL-1beta) and tumour necrosis factor alpha (TNF-alpha). Albuterol 0-14 C-C motif chemokine ligand 2 Homo sapiens 154-184 31680470-3 2020 (R)-salbutamol significantly inhibited LPS-induced M1 macrophage polarization and downregulated expressions of typical M1 macrophage cytokines, including monocyte chemotactic protein-1 (MCP-1), interleukin-1beta (IL-1beta) and tumour necrosis factor alpha (TNF-alpha). Albuterol 0-14 C-C motif chemokine ligand 2 Homo sapiens 186-191 31693860-5 2020 Pan-HDACi suberoylanilide hydroxamic acid (SAHA) and/or ITF2357 (givinostat) significantly reduced TNFalpha- and P. gingivalis-inducible expression and/or production of a cluster of inflammatory mediators in healthy donor GFs (IL1B, CCL2, CCL5, CXCL10, COX2, and MMP3) without affecting cell viability. vorinostat 10-41 C-C motif chemokine ligand 2 Homo sapiens 233-237 31693860-5 2020 Pan-HDACi suberoylanilide hydroxamic acid (SAHA) and/or ITF2357 (givinostat) significantly reduced TNFalpha- and P. gingivalis-inducible expression and/or production of a cluster of inflammatory mediators in healthy donor GFs (IL1B, CCL2, CCL5, CXCL10, COX2, and MMP3) without affecting cell viability. vorinostat 43-47 C-C motif chemokine ligand 2 Homo sapiens 233-237 31693860-5 2020 Pan-HDACi suberoylanilide hydroxamic acid (SAHA) and/or ITF2357 (givinostat) significantly reduced TNFalpha- and P. gingivalis-inducible expression and/or production of a cluster of inflammatory mediators in healthy donor GFs (IL1B, CCL2, CCL5, CXCL10, COX2, and MMP3) without affecting cell viability. givinostat hydrochloride 56-63 C-C motif chemokine ligand 2 Homo sapiens 233-237 31693860-5 2020 Pan-HDACi suberoylanilide hydroxamic acid (SAHA) and/or ITF2357 (givinostat) significantly reduced TNFalpha- and P. gingivalis-inducible expression and/or production of a cluster of inflammatory mediators in healthy donor GFs (IL1B, CCL2, CCL5, CXCL10, COX2, and MMP3) without affecting cell viability. givinostat 65-75 C-C motif chemokine ligand 2 Homo sapiens 233-237 31460824-16 2020 Postprandial serum and PA +25OHCH caused increase of IL-33, MCP-1, ICAM-1, IL-32, VEGF, and CX3C-chemokine mRNA expression as compared with fasting serum (P < 0.05). Protactinium 23-25 C-C motif chemokine ligand 2 Homo sapiens 60-65 31460824-16 2020 Postprandial serum and PA +25OHCH caused increase of IL-33, MCP-1, ICAM-1, IL-32, VEGF, and CX3C-chemokine mRNA expression as compared with fasting serum (P < 0.05). 25ohch 27-33 C-C motif chemokine ligand 2 Homo sapiens 60-65 31748348-4 2020 KDM6-specific chemical inhibition (GSK J4) in BMDC led to decreased production of chemokines and cytokines associated with the inflammatory response during RSV infection (i.e., CCL-2, CCL-3, CCL-5, IL-6) as well as decreased MHC class II and costimulatory marker (CD80/86) expression. kdm6 0-4 C-C motif chemokine ligand 2 Homo sapiens 177-182 31705896-0 2020 CCL2/CCR2 Chemokine System in Embryonic Hypothalamus: Involvement in Sexually Dimorphic Stimulatory Effects of Prenatal Ethanol Exposure on Peptide-Expressing Neurons. Ethanol 120-127 C-C motif chemokine ligand 2 Homo sapiens 0-4 31996529-9 2020 The co-addition of geranylgeraniol with ZA resulted in the significant down-regulation of these three genes along with CCL2, TGFBR1, ENG, and CXCL1. geranylgeraniol 19-34 C-C motif chemokine ligand 2 Homo sapiens 119-123 31996529-9 2020 The co-addition of geranylgeraniol with ZA resulted in the significant down-regulation of these three genes along with CCL2, TGFBR1, ENG, and CXCL1. zol 40-42 C-C motif chemokine ligand 2 Homo sapiens 119-123 31705896-4 2020 We found that prenatal ethanol exposure increases the expression and density of CCL2 and CCR2 cells along with MCH neurons in the LH and the colocalization of CCL2 with MCH. Ethanol 23-30 C-C motif chemokine ligand 2 Homo sapiens 80-84 31705896-4 2020 We found that prenatal ethanol exposure increases the expression and density of CCL2 and CCR2 cells along with MCH neurons in the LH and the colocalization of CCL2 with MCH. Ethanol 23-30 C-C motif chemokine ligand 2 Homo sapiens 159-163 31705896-5 2020 We also discovered that these effects are sexually dimorphic, consistently stronger in female embryos, and are blocked by maternal administration of a CCL2 antibody (1 and 5 microg/day, i.p., E10-E15) that neutralizes endogenous CCL2 and of a CCR2 antagonist INCB3344 (1 mg/day, i.p., E10-E15) that blocks CCL2"s main receptor. INCB3344 259-267 C-C motif chemokine ligand 2 Homo sapiens 151-155 31705896-6 2020 These results, which in the embryo anatomically and functionally link the CCL2/CCR2 system to MCH neurons in the LH, suggest an important role for this neuroimmune system in mediating ethanol"s sexually dimorphic, stimulatory effect on MCH neurons that may promote higher level of alcohol consumption described in females. Ethanol 184-191 C-C motif chemokine ligand 2 Homo sapiens 74-78 31705896-6 2020 These results, which in the embryo anatomically and functionally link the CCL2/CCR2 system to MCH neurons in the LH, suggest an important role for this neuroimmune system in mediating ethanol"s sexually dimorphic, stimulatory effect on MCH neurons that may promote higher level of alcohol consumption described in females. Ethanol 281-288 C-C motif chemokine ligand 2 Homo sapiens 74-78 31892218-5 2019 The hDPSCs exposed to HEMA let to an increment of ROS formation and in the expression of high levels of inflammatory mediators such as nuclear factor-kappaB (NFkB), inflammatory cytokines such as interleukin IL6, IL8, interferon (IFN)gamma and monocyte chemoattractant protein (MCP)1. poly(2-hydroxyethylmethacrylate)-TiO2 22-26 C-C motif chemokine ligand 2 Homo sapiens 244-283 31630418-7 2020 After blocking Act1/TRAF6/p38MAPK cascade and interfering AP-1 with Curcumin or c-Jun siRNA, CCL2 expression induced by IL-17 was significantly attenuated at both mRNA and protein levels. Curcumin 68-76 C-C motif chemokine ligand 2 Homo sapiens 93-97 31851935-3 2019 Metformin interrupts bidirectional signaling between tumor and mesothelial cells by blocking OvCa cell TGF-beta signaling and mesothelial cell production of CCL2 and IL-8. Metformin 0-9 C-C motif chemokine ligand 2 Homo sapiens 157-161 31614141-5 2019 In LPS-stimulated human brain microvascular endothelial cells (HBMECs), 10-HDA decreased the expression of chemokines (CCL-2 and CCL-3), adhesion molecules (ICAM-1 and VCAM-1), reactive oxygen species, matrix metalloproteinases (MMP-2 and MMP-9) and increased the expression of tight junction proteins. 10-hydroxy-2-decenoic acid 72-78 C-C motif chemokine ligand 2 Homo sapiens 119-124 31539553-5 2019 We found that agonism of GPR39 using its specific agonist TC-G 1008 significantly ameliorated important markers of RA, including oxidative stress, mitochondrial dysfunction, expression of proinflammatory cytokines including interleukin-1beta (IL-1beta), IL-6, and monocyte chemoattractant protein 1 (MCP-1), and secretion of key matrix metalloproteinases (MMPs) including MMP-1, MMP-3 and MMP-13. GPR39-C3 58-67 C-C motif chemokine ligand 2 Homo sapiens 264-298 31539553-5 2019 We found that agonism of GPR39 using its specific agonist TC-G 1008 significantly ameliorated important markers of RA, including oxidative stress, mitochondrial dysfunction, expression of proinflammatory cytokines including interleukin-1beta (IL-1beta), IL-6, and monocyte chemoattractant protein 1 (MCP-1), and secretion of key matrix metalloproteinases (MMPs) including MMP-1, MMP-3 and MMP-13. GPR39-C3 58-67 C-C motif chemokine ligand 2 Homo sapiens 300-305 31610186-4 2019 Among the 17 flavonoids tested, only apigenin (flavones), luteolin (flavones), daidzein (isoflavones) and genistein (isoflavones) reduced LPS-induced release of inflammatory cytokines/chemokines interleukin (IL)-6, IL-8 and monocyte chemoattractant protein-1 in BEAS-2B cells. Genistein 106-115 C-C motif chemokine ligand 2 Homo sapiens 224-258 31526917-5 2019 CCL2 (p = 0.039), and CCL5 (p = 0.001) levels were significantly higher in fingolimod-treated patients than healthy controls, whereas end-of-study serum levels of IL-6, IL-8, IL-17A, IL-22, IL-23, TNF-alpha, CXCL10, and CXCL13 were comparable to the baseline levels. Fingolimod Hydrochloride 75-85 C-C motif chemokine ligand 2 Homo sapiens 0-4 31669588-8 2019 The gene expression and the release of CCL5 and CCL2 stimulated by IL-33 were significantly inhibited by 2 h pre-treatment with methoxyluteolin (10, 50, 100 muM). methoxyluteolin 128-143 C-C motif chemokine ligand 2 Homo sapiens 48-52 31669588-0 2019 IL-33 stimulates human mast cell release of CCL5 and CCL2 via MAPK and NF-kappaB, inhibited by methoxyluteolin. methoxyluteolin 95-110 C-C motif chemokine ligand 2 Homo sapiens 53-57 31811113-4 2019 RESULTS Cells predisposed to MG demonstrated an increase in oxidative stress with augmented (P<0.01) inflammatory cytokines such as cyclooxygenase (COX)-2, chemokine receptor CXCR4, interleukin (IL)-6, IL-8, monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecule 1 (ICAM-1) genes. Pyruvaldehyde 29-31 C-C motif chemokine ligand 2 Homo sapiens 211-245 31811113-4 2019 RESULTS Cells predisposed to MG demonstrated an increase in oxidative stress with augmented (P<0.01) inflammatory cytokines such as cyclooxygenase (COX)-2, chemokine receptor CXCR4, interleukin (IL)-6, IL-8, monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecule 1 (ICAM-1) genes. Pyruvaldehyde 29-31 C-C motif chemokine ligand 2 Homo sapiens 247-252 31816951-5 2019 In our xenograft RCC model, intra-tumoral MCP-1 injection down-regulated Ki67 expression and reduced tumor size. ki67 73-77 C-C motif chemokine ligand 2 Homo sapiens 42-47 31816951-8 2019 ER stress-mediated apoptosis in MCP-1-treated RCC cells was confirmed using Terminal deoxynucleotidyl transferase dUTP Nick-End Labeling (TUNEL) assay. deoxyuridine triphosphate 114-118 C-C motif chemokine ligand 2 Homo sapiens 32-37 30607767-5 2019 The MCP-1 is also a known potent chemotactic factor for monocytes and macrophages that can stimulate them to produce superoxide and other mediators. Superoxides 117-127 C-C motif chemokine ligand 2 Homo sapiens 4-9 31106593-6 2019 Furthermore, salicin inhibits IL-1beta-induced production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1), vascular adhesion molecules such as intercellular cell adhesion molecule-1 (iCAM-1) and vascular cell adhesion molecule 1 (VCAM-1), and high-mobility group protein 1 (HMGB-1). salicin 13-20 C-C motif chemokine ligand 2 Homo sapiens 163-197 31106593-6 2019 Furthermore, salicin inhibits IL-1beta-induced production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1), vascular adhesion molecules such as intercellular cell adhesion molecule-1 (iCAM-1) and vascular cell adhesion molecule 1 (VCAM-1), and high-mobility group protein 1 (HMGB-1). salicin 13-20 C-C motif chemokine ligand 2 Homo sapiens 199-204 31672785-5 2019 Because breast cancer tissues express the CCR2 ligand CCL2, the activation and egress of tumor antigen-specific Tregs in the BM resulted in the accumulation of Tregs in breast tumor tissue. tregs 112-117 C-C motif chemokine ligand 2 Homo sapiens 54-58 31672785-5 2019 Because breast cancer tissues express the CCR2 ligand CCL2, the activation and egress of tumor antigen-specific Tregs in the BM resulted in the accumulation of Tregs in breast tumor tissue. tregs 160-165 C-C motif chemokine ligand 2 Homo sapiens 54-58 31815868-7 2019 Apigenin reversed the effects of TMAO on mRNA expression of LOX-1, SREC, SR-PSOX, NLRP3, ASC, TXNIP, VCAM-1, ICAM-1, and MCP-1, as well as protein expression of LOX-1, the adhesion molecule ICAM-1, and the inflammasome protein NLRP3. trimethyloxamine 33-37 C-C motif chemokine ligand 2 Homo sapiens 121-126 31730488-12 2019 In contrast, levels of MCP-1, a pro-inflammatory cytokine, were reduced in the conditioned medium of IPTD-MSCs treated with a combination of DMOG and TNF-alpha. Glyprothiazol 101-105 C-C motif chemokine ligand 2 Homo sapiens 23-28 32203941-5 2019 Exposure of MC to the studied dialysates caused intracellular oxidative stress and significantly increased expression of the genes regulating the synthesis of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), transforming growth factor-beta (TGF-beta), vascular cell adhesion molecule 1 (VCAM-1) and vascular endothelial growth factor (VEGF). Methylcholanthrene 12-14 C-C motif chemokine ligand 2 Homo sapiens 181-215 32203941-5 2019 Exposure of MC to the studied dialysates caused intracellular oxidative stress and significantly increased expression of the genes regulating the synthesis of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), transforming growth factor-beta (TGF-beta), vascular cell adhesion molecule 1 (VCAM-1) and vascular endothelial growth factor (VEGF). Methylcholanthrene 12-14 C-C motif chemokine ligand 2 Homo sapiens 217-222 32203941-6 2019 Secretion of the studied molecules from MC treated with dialysates was increased: by 96% for IL-6 (P < 0.01), 34% for MCP-1(P < 0.01), 24% for TGF-beta (P < 0.01), 27% for VCAM-1 (P < 0.01), and by 15% for VEGF (P < 0.01). Methylcholanthrene 40-42 C-C motif chemokine ligand 2 Homo sapiens 118-123 31871502-7 2019 The relationship between MCP-1 and DR and DME was significant, in which the SMD was (0.49 (0.09, 0.89)) and (1.49 (0.78, 2.20)), respectively. dimethylethylsilylimidazole 42-45 C-C motif chemokine ligand 2 Homo sapiens 25-30 31766780-9 2019 The chlorogenic acid isomers and caffeic acid inhibited the TNF release, with cryptochlorogenic acid exerting the most distinct effects, as well as decreasing the release of IL-6 and MCP-1. caffeic acid 33-45 C-C motif chemokine ligand 2 Homo sapiens 183-188 31824305-12 2019 CHC and HC dose-dependently reduced IL-1beta and CCL2 messenger RNA (mRNA) expression. cyclohexyl 4'-O-cyclohexylcellobiose 0-3 C-C motif chemokine ligand 2 Homo sapiens 49-53 31824305-12 2019 CHC and HC dose-dependently reduced IL-1beta and CCL2 messenger RNA (mRNA) expression. n-hexyl beta-D-glucopyranoside 1-3 C-C motif chemokine ligand 2 Homo sapiens 49-53 31744516-13 2019 Furthermore, we also revealed that elevated MCP-1 expression induced by SIRT4 downregulation was responsible for increased TAM infiltration in peritumour tissues. TAM protocol 123-126 C-C motif chemokine ligand 2 Homo sapiens 44-49 31815868-7 2019 Apigenin reversed the effects of TMAO on mRNA expression of LOX-1, SREC, SR-PSOX, NLRP3, ASC, TXNIP, VCAM-1, ICAM-1, and MCP-1, as well as protein expression of LOX-1, the adhesion molecule ICAM-1, and the inflammasome protein NLRP3. Apigenin 0-8 C-C motif chemokine ligand 2 Homo sapiens 121-126 31759251-7 2019 In vitro migration assay confirmed that exogenous CCL2 could rescue the impaired ability of ICC-Fbs to attract Gr-1+ cells caused by fibroblastic FAP knockdown. N-fluorobenzenesulfonimide 95-99 C-C motif chemokine ligand 2 Homo sapiens 50-54 31779275-6 2019 Transcriptional profiling revealed that various genes coding for cytokines and other proinflammatory proteins were upregulated upon recombinant alpha-MMC treatment in THP-1 cells, including MCP-1, IL-8, IL-1beta, and TNF-alpha. MK 316 144-153 C-C motif chemokine ligand 2 Homo sapiens 190-195 31730488-12 2019 In contrast, levels of MCP-1, a pro-inflammatory cytokine, were reduced in the conditioned medium of IPTD-MSCs treated with a combination of DMOG and TNF-alpha. dimethyloxallyl glycine 141-145 C-C motif chemokine ligand 2 Homo sapiens 23-28 31718684-12 2019 RESULTS: We found that ALCAR reduces cell proliferation, induces apoptosis, hinders the production of pro inflammatory cytokines (TNF-alpha and IFN-gamma) and of chemokines CCL2, CXCL12 and receptor CXCR4 involved in the chemotactic axis and impairs the adhesion, migration and invasion capabilities of PCa and BPH cells in vitro. Acetylcarnitine 23-28 C-C motif chemokine ligand 2 Homo sapiens 173-177 31718684-13 2019 ALCAR exerts angiopreventive activities on PCa by reducing production/release of pro angiogenic factors (VEGF, CXCL8, CCL2, angiogenin) and metalloprotease MMP-9. Acetylcarnitine 0-5 C-C motif chemokine ligand 2 Homo sapiens 118-122 31708994-7 2019 Initial exposure to H2O2 or TNFalpha enhanced SF senescence and increased mRNA expression of IL6, CXCL8, CCL2 and MMP3 and proteins secretion. Water 20-24 C-C motif chemokine ligand 2 Homo sapiens 105-109 30668739-8 2019 Participants receiving the ART+ regimen had lower median plasma CCL2 levels at week 24, and at week 96 had lower plasma neopterin levels. art+ 27-31 C-C motif chemokine ligand 2 Homo sapiens 64-68 31787969-5 2019 CD3+TCRalphabeta+ macrophages secrete IL-1beta, IL-6 IP-10, and MCP-1 by both tmTNF- and CD3-dependent pathways, while CD3+TCRalphabeta- macrophages specifically produce IFN-gamma, TNF, and MIP-1beta by a CD3-dependent pathway. hepta-6-sulfato-beta-cyclodextrin 0-16 C-C motif chemokine ligand 2 Homo sapiens 64-69 31708994-9 2019 Treatment of senescent SF with the senolytic drug fenofibrate normalized IL6, CXCL8 and CCL2 mRNA expression. Fenofibrate 50-61 C-C motif chemokine ligand 2 Homo sapiens 88-92 32002296-7 2020 Peripheral blood mononuclear cells (PBMCs) secreted high levels of CXCL10, CCL2 and IFN-gamma in response to co-culture with melphalan-exposed melanoma cells in vitro. Melphalan 125-134 C-C motif chemokine ligand 2 Homo sapiens 75-79 31659097-10 2019 Similar trends were seen for apigenin-mediated down-regulation of TNFalpha-up-regulated transcripts: IKBKE (TNFalpha: 4.55 FC vs. control, p<0.001; and TNFalpha plus apigenin: -4.92 FC, p<0.001), CCL2 (2.19 FC, p<0.002; and -2.12 FC, p<0.003), IL6 (3.25 FC, p<0.020; and -2.85 FC, p<0.043) and CSF2 (TNFalpha +6.04 FC, p<0.001; and -2.36 FC, p<0.007). Apigenin 29-37 C-C motif chemokine ligand 2 Homo sapiens 202-206 31545398-8 2019 The present study also demonstrated that bexarotene exerted an anti-inflammatory effect by downregulating expression of interleukin (IL)-6, IL-8, monocyte chemoattractant protein-1, and high mobility group box-1. Bexarotene 41-51 C-C motif chemokine ligand 2 Homo sapiens 146-180 31343124-5 2019 In CXA-10-202, a consistent decrease from baseline was observed with CXA-10 150 mg dose, but not 25 or 450 mg doses, for biomarkers of altered inflammation and metabolic dysfunction, including leptin, triglycerides, cholesterol, MCP-1, and IL-6. 10-nitro-oleic acid 3-9 C-C motif chemokine ligand 2 Homo sapiens 229-234 31343124-5 2019 In CXA-10-202, a consistent decrease from baseline was observed with CXA-10 150 mg dose, but not 25 or 450 mg doses, for biomarkers of altered inflammation and metabolic dysfunction, including leptin, triglycerides, cholesterol, MCP-1, and IL-6. 10-nitro-oleic acid 69-75 C-C motif chemokine ligand 2 Homo sapiens 229-234 31872186-8 2019 Sensitivity to tofacitinib was evaluated by measuring CCL2 inhibition using quantitative polymerase chain reaction. tofacitinib 15-26 C-C motif chemokine ligand 2 Homo sapiens 54-58 31521728-6 2019 We further identified that Au NRs significantly decreased eNOS mRNA/p-eNOS proteins as well as increased MCP-1 mRNA/sMCP-1 release, which are targets of KLF2. Gold 27-29 C-C motif chemokine ligand 2 Homo sapiens 105-110 31665675-5 2019 We also found that TNF-alpha-enhanced protein expressions of vascular cell adhesion molecule 1 (VCAM-1), monocyte chemotactic protein-1 (MCP-1) and nuclear factor (NF)-kappaB translocation were synergistically reduced by the combined curcumin and luteolin in EA.hy 926 cells while the individual chemical did not have this inhibitory effect. Curcumin 234-242 C-C motif chemokine ligand 2 Homo sapiens 105-135 31665675-7 2019 Therefore, combined curcumin and luteolin at physiological concentrations synergistically inhibits TNF-alpha-induced monocytes adhesion to endothelial cells and expressions of MCP-1 and VCAM-1 via suppressing NF-kappaB translocation into the nucleus. Curcumin 20-28 C-C motif chemokine ligand 2 Homo sapiens 176-181 31665675-7 2019 Therefore, combined curcumin and luteolin at physiological concentrations synergistically inhibits TNF-alpha-induced monocytes adhesion to endothelial cells and expressions of MCP-1 and VCAM-1 via suppressing NF-kappaB translocation into the nucleus. Luteolin 33-41 C-C motif chemokine ligand 2 Homo sapiens 176-181 31385893-9 2019 RESULTS: Losartan-treated human dermal fibroblasts displayed decreased contractile activity, migration, and gene expression of transforming growth factor-beta1, collagen I, and monocyte chemoattractant protein-1 relative to controls (p < 0.05). Losartan 9-17 C-C motif chemokine ligand 2 Homo sapiens 177-211 31437494-7 2019 CBD significantly attenuated LPS-induced NF-kappaB activity, IL-8, and MCP-1 release from macrophages. Cannabidiol 0-3 C-C motif chemokine ligand 2 Homo sapiens 71-76 31383729-12 2019 Collectively, this study demonstrates that the anti-inflammatory properties of THC suppress TLR7-induced monocyte secretion of IL-1beta through CB2, which results in decreased astrocyte secretion of MCP-1 and IL-6. Dronabinol 79-82 C-C motif chemokine ligand 2 Homo sapiens 199-204 31665136-9 2019 It also reveals the butein inhibitory effect on CCL2 expression with a possible association with IKBKE downregulation in MDA-MB-231 cells only, indicating that Caucasians and African Americans TNBC cells respond differently to butein treatment. butein 20-26 C-C motif chemokine ligand 2 Homo sapiens 48-52 31295376-10 2019 Increased expression of IL-22 resulted in an increase in the number of chemotactic macrophages, but was reversed by alphaIL-22 and CCL2 antagonist (alphaCCL2). alphaccl2 148-157 C-C motif chemokine ligand 2 Homo sapiens 131-135 31049957-7 2019 RESULTS: Production of IL-6, IL-8, MCP-1, and OPG was significantly increased by Poly I:C or Pam3CSK4 to a similar extent. Poly I-C 81-89 C-C motif chemokine ligand 2 Homo sapiens 35-40 31635102-12 2019 (4) Conclusions: Microglial HO-1 induction with endogenous CO production functions as a crucial signaling pathway in blood-induced inflammation, determining microglial MCP-1 production and the extent of neuronal cell death. Carbon Dioxide 59-61 C-C motif chemokine ligand 2 Homo sapiens 168-173 31737185-10 2019 At the molecular level, saxagliptin suppresses OGD/R-induced expression of pro-inflammatory cytokines and production of vascular adhesion molecules including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, monocyte chemoattractant protein 1 (MCP-1), vascular cellular adhesion molecule 1 (VCAM-1), and E-selectin. saxagliptin 24-35 C-C motif chemokine ligand 2 Homo sapiens 219-253 31737185-10 2019 At the molecular level, saxagliptin suppresses OGD/R-induced expression of pro-inflammatory cytokines and production of vascular adhesion molecules including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, monocyte chemoattractant protein 1 (MCP-1), vascular cellular adhesion molecule 1 (VCAM-1), and E-selectin. saxagliptin 24-35 C-C motif chemokine ligand 2 Homo sapiens 255-260 31220426-11 2019 RESULTS: Overall Mo from control subjects exposed to ASA showed increased secretion of IL-1RA, IL-8, MCP-1, and TNF-alpha and Mo from stroke patients showed greater release of IL-1RA and MCP-1. Aspirin 53-56 C-C motif chemokine ligand 2 Homo sapiens 101-106 31220426-13 2019 In addition, in co-cultures independent of Mo origin, ASA reduced IL-6, IL-8, MCP-1, and TNF-alpha. Aspirin 54-57 C-C motif chemokine ligand 2 Homo sapiens 78-83 31409556-10 2019 Colchicine treatment markedly reduced TC levels of CCL2, CCL5, and CX3CL1 in patients with ACS (P < 0.05). Colchicine 0-10 C-C motif chemokine ligand 2 Homo sapiens 51-55 31409556-10 2019 Colchicine treatment markedly reduced TC levels of CCL2, CCL5, and CX3CL1 in patients with ACS (P < 0.05). Technetium 38-40 C-C motif chemokine ligand 2 Homo sapiens 51-55 31409556-11 2019 In vitro colchicine suppressed CCL2 gene expression in stimulated monocytes (P < 0.05). Colchicine 9-19 C-C motif chemokine ligand 2 Homo sapiens 31-35 31593984-5 2019 Results: Treatment with curcumin resulted in a dose- and time-dependent decrease in IL-1beta-induced synthesis of inflammatory cytokines, including IL-6, IL-8, MCP-1, and ICAM-1 at both mRNA and protein levels. Curcumin 24-32 C-C motif chemokine ligand 2 Homo sapiens 160-165 31383729-0 2019 Delta9-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. Dronabinol 0-27 C-C motif chemokine ligand 2 Homo sapiens 81-115 31383729-8 2019 THC treatment of the TLR7-stimulated coculture suppressed monocyte secretion of IL-1beta, resulting in decreased astrocyte production of MCP-1 and IL-6. Dronabinol 0-3 C-C motif chemokine ligand 2 Homo sapiens 137-142 31594182-34 2019 The expression level of human monocyte chemoattractant protein 1 (MCP-1) in hASCs of AGEs-high glucose combination group showed increasing trend with the prolongation of culture time, while the expression level of growth-regulated oncogene (GRO) on PCD 6 was significantly higher than that on PCD 4 within the same group (P<0.05); the expression levels of MCP-1 and GRO in hASCs of protein-high osmotic pressure combination group showed decreasing trend with the prolongation of culture time. Glucose 95-102 C-C motif chemokine ligand 2 Homo sapiens 30-64 31389404-7 2019 RESULTS: CCL2:Cr was significant independent predictor of BK virus nephropathy (OR 1.1 95% CI 1.0-1.2; p=0.04). Chromium 14-16 C-C motif chemokine ligand 2 Homo sapiens 9-13 31389404-9 2019 CONCLUSIONS: CCL2:Cr and CXCL10:Cr may seem to predict BK virus nephropathy. Chromium 18-20 C-C motif chemokine ligand 2 Homo sapiens 13-17 31363829-7 2019 Among the entire patient population, SUA levels significantly increased 3 months after starting treatment with TNFis (279.5 [84.0] vs. 299.0 [102.0] mumol/l, p < 0.0001), while the levels of CRP, IL-6, IL-8, and MCP-1 significantly decreased. sua 37-40 C-C motif chemokine ligand 2 Homo sapiens 215-220 31771729-1 2019 OBJECTIVE: To investigate the effects of heparin on the secretion of monocyte chemotactic protein-1 (MCP-1) in human umbilical vein endothelial cells (HUVEC) and the adhesion of monocytes to endothelial cells stimulated by lipopolysaccharide (LPS). Heparin 41-48 C-C motif chemokine ligand 2 Homo sapiens 69-99 31771729-1 2019 OBJECTIVE: To investigate the effects of heparin on the secretion of monocyte chemotactic protein-1 (MCP-1) in human umbilical vein endothelial cells (HUVEC) and the adhesion of monocytes to endothelial cells stimulated by lipopolysaccharide (LPS). Heparin 41-48 C-C motif chemokine ligand 2 Homo sapiens 101-106 31771729-7 2019 RESULTS: Compared with the PBS control group, the MCP-1 mRNA expression significantly increased at 6 hours and 12 hours after LPS stimulation and peaked at 6 hours, then decreased gradually, but remained significantly higher than the PBS control group at 12 hours [2-DeltaDeltaCt: 16.41 (15.03, 18.00) vs. 1.00 (0.80, 1.26) at 6 hours, 9.27 (8.11, 9.85) vs. 1.00 (0.84, 1.20) at 12 hours, both P < 0.05]. pbs 27-30 C-C motif chemokine ligand 2 Homo sapiens 50-55 31771729-7 2019 RESULTS: Compared with the PBS control group, the MCP-1 mRNA expression significantly increased at 6 hours and 12 hours after LPS stimulation and peaked at 6 hours, then decreased gradually, but remained significantly higher than the PBS control group at 12 hours [2-DeltaDeltaCt: 16.41 (15.03, 18.00) vs. 1.00 (0.80, 1.26) at 6 hours, 9.27 (8.11, 9.85) vs. 1.00 (0.84, 1.20) at 12 hours, both P < 0.05]. pbs 234-237 C-C motif chemokine ligand 2 Homo sapiens 50-55 31771729-8 2019 Heparin preconditioning significantly reduced LPS-induced MCP-1 mRNA expression [2-DeltaDeltaCt: 2.06 (1.72, 2.46) vs. 16.41 (15.03, 18.00) at 6 hours, 2.46 (2.19, 4.56) vs. 9.27 (8.11, 9.85) at 12 hours, both P < 0.05]. Heparin 0-7 C-C motif chemokine ligand 2 Homo sapiens 58-63 31771729-11 2019 CONCLUSIONS: Heparin preconditioning could inhibit the MCP-1 mRNA expression , thereby reduce the adhesion of THP-1 to HUVEC, thus play a protective role in sepsis. Heparin 13-20 C-C motif chemokine ligand 2 Homo sapiens 55-60 31548589-6 2019 Evaluation of the effect of histamine on LPS-induced CCL2 secretion showed an inhibitory effect in the majority of adults, whereas this effect was detectable in all NBs. Histamine 28-37 C-C motif chemokine ligand 2 Homo sapiens 53-57 31548589-7 2019 Histamine receptor (HR) blockage revealed partial involvement of H1R, H2R and H4R in LPS-induced CCL2 inhibition in MNCs from both NBs and adults. Histamine 0-9 C-C motif chemokine ligand 2 Homo sapiens 97-101 31548589-11 2019 The immunomodulatory role of histamine on CCL2 and CXCL8 was detected at the transcript and protein levels. Histamine 29-38 C-C motif chemokine ligand 2 Homo sapiens 42-46 31594182-34 2019 The expression level of human monocyte chemoattractant protein 1 (MCP-1) in hASCs of AGEs-high glucose combination group showed increasing trend with the prolongation of culture time, while the expression level of growth-regulated oncogene (GRO) on PCD 6 was significantly higher than that on PCD 4 within the same group (P<0.05); the expression levels of MCP-1 and GRO in hASCs of protein-high osmotic pressure combination group showed decreasing trend with the prolongation of culture time. Glucose 95-102 C-C motif chemokine ligand 2 Homo sapiens 66-71 31565056-3 2019 We further investigated the effects of RAGE-aptamer on oxidative stress generation, RAGE, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1) gene expression in N epsilon -(carboxymethyl)lysine (CML)-exposed G361 melanoma cells in vitro. aspartyllysine 201-231 C-C motif chemokine ligand 2 Homo sapiens 137-171 31540502-7 2019 EPDA suppressed the production of monocyte chemoattractant protein-1 (MCP-1), and interleukin-6 (IL-6) in both cell lines, and nitric oxide (NO), and macrophage-inflammatory protein-3alpha (MIP3A) in RAW 264.7 macrophages. epda 0-4 C-C motif chemokine ligand 2 Homo sapiens 34-68 31540502-7 2019 EPDA suppressed the production of monocyte chemoattractant protein-1 (MCP-1), and interleukin-6 (IL-6) in both cell lines, and nitric oxide (NO), and macrophage-inflammatory protein-3alpha (MIP3A) in RAW 264.7 macrophages. epda 0-4 C-C motif chemokine ligand 2 Homo sapiens 70-75 31565056-3 2019 We further investigated the effects of RAGE-aptamer on oxidative stress generation, RAGE, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1) gene expression in N epsilon -(carboxymethyl)lysine (CML)-exposed G361 melanoma cells in vitro. aspartyllysine 201-231 C-C motif chemokine ligand 2 Homo sapiens 173-178 31237033-3 2019 Moreover, saponin induced IL1beta and MCP1 release and did not affect the complement system. Saponins 10-17 C-C motif chemokine ligand 2 Homo sapiens 38-42 31237033-6 2019 Inulin, agarose and cellulose induced IL1beta and MCP1 release, while dextran had no effect on cytokine secretion. Sepharose 8-15 C-C motif chemokine ligand 2 Homo sapiens 50-54 31237033-6 2019 Inulin, agarose and cellulose induced IL1beta and MCP1 release, while dextran had no effect on cytokine secretion. Cellulose 20-29 C-C motif chemokine ligand 2 Homo sapiens 50-54 31237033-8 2019 The inorganic compound aluminium hydroxide, Al(OH)3 , activated the complement system very efficiently (all three pathways) but only induced MCP1 release. Aluminum Hydroxide 23-42 C-C motif chemokine ligand 2 Homo sapiens 141-145 31237033-8 2019 The inorganic compound aluminium hydroxide, Al(OH)3 , activated the complement system very efficiently (all three pathways) but only induced MCP1 release. Aluminum Hydroxide 44-51 C-C motif chemokine ligand 2 Homo sapiens 141-145 31146011-6 2019 Tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) were decreased in the cortex and hippocampus of HHcy animals following NaHS supplementation. sodium bisulfide 180-184 C-C motif chemokine ligand 2 Homo sapiens 66-100 30539387-9 2019 However, addition of ER stress blocker, 4-PBA in the abnormal-iodine treated cells, decreased the expressions of p-P38, PERK, IRE1, ATF6, and MCP-1. 4-phenylbutylamine 40-45 C-C motif chemokine ligand 2 Homo sapiens 142-147 30539387-10 2019 Similarly, P38/MAPK activity inhibitor, SB203580, also decreased the expressions of p-P38 and MCP-1. SB 203580 40-48 C-C motif chemokine ligand 2 Homo sapiens 94-99 30539387-11 2019 Abnormal iodine nutrition status triggered ER stress and upregulated MCP-1 expression through P38/MAPK signaling pathway in thyrocyte. Iodine 9-15 C-C motif chemokine ligand 2 Homo sapiens 69-74 31567972-6 2019 Levels of IL-6, IL-7, and monocyte chemoattractant protein 1 were higher with 5-aminosalicylic acid (5-ASA) + Azathioprine therapy than controls (P < .05). Mesalamine 78-99 C-C motif chemokine ligand 2 Homo sapiens 26-60 31567972-6 2019 Levels of IL-6, IL-7, and monocyte chemoattractant protein 1 were higher with 5-aminosalicylic acid (5-ASA) + Azathioprine therapy than controls (P < .05). Mesalamine 101-106 C-C motif chemokine ligand 2 Homo sapiens 26-60 31567972-6 2019 Levels of IL-6, IL-7, and monocyte chemoattractant protein 1 were higher with 5-aminosalicylic acid (5-ASA) + Azathioprine therapy than controls (P < .05). Azathioprine 110-122 C-C motif chemokine ligand 2 Homo sapiens 26-60 30539387-0 2019 Abnormal Iodine Nutrition-Induced ER Stress Upregulates MCP-1 Expression Through P38/MAPK Signaling Pathway in Thyroid Cells. Iodine 9-15 C-C motif chemokine ligand 2 Homo sapiens 56-61 30539387-5 2019 Present study aims to investigate how iodine nutrition status influences MCP-1 expression through P38/MAPK pathway as well as the roles of ER stress in this process. Iodine 38-44 C-C motif chemokine ligand 2 Homo sapiens 73-78 31254955-9 2019 In the in vitro study, the increased secretion of MCP-1 was attenuated with linalool treatment in lipopolysaccharide (LPS)-stimulated H292 airway epithelial cells. linalool 76-84 C-C motif chemokine ligand 2 Homo sapiens 50-55 31146011-7 2019 Moreover, NaHS supplementation also decreased the TNF-alpha, IL-6 and MCP-1 in the serum of HHcy animals. sodium bisulfide 10-14 C-C motif chemokine ligand 2 Homo sapiens 70-75 31469844-4 2019 RESULTS: AL tissues had elevated levels of TNF-family members sTNFR2, TNFSF14, sFasL, sBAFF, cytokines/chemokines IL8, CCL2, IL1RA/IL36, sIL6R, and growth factors sAREG, CSF1, comparing to non-AL. Aluminum 9-11 C-C motif chemokine ligand 2 Homo sapiens 119-123 31455007-8 2019 The obtained data implies that glucose-induced insulin secretion (GIS) in pancreatic beta cells is significantly attenuated by IH, and that IH increases selenoprotein P, which is one of the hepatokines, as well as TNF-alpha, CCL-2, and resistin, members of adipokines, to induce insulin resistance via direct cellular mechanisms. Glucose 31-38 C-C motif chemokine ligand 2 Homo sapiens 225-230 31211863-11 2019 An increased mRNA expression of IL-6, IL-8, and MCP-1 by FAEEs is key finding to suggest a metabolic basis of EtOH-induced inflammatory response. Ethanol 110-114 C-C motif chemokine ligand 2 Homo sapiens 48-53 31136945-0 2019 Imiquimod and interferon-alpha augment monocyte-mediated astrocyte secretion of MCP-1, IL-6 and IP-10 in a human co-culture system. Imiquimod 0-9 C-C motif chemokine ligand 2 Homo sapiens 80-85 31032885-7 2019 Attenuation of DAG catabolism in monocytes by inhibiting DAG kinase (R59949) or DAG lipase (RHC80267) activity suppressed CCL2-evoked Ca2+ signalling and transwell migration in monocytes. dag 15-18 C-C motif chemokine ligand 2 Homo sapiens 122-126 31032885-12 2019 CONCLUSIONS AND IMPLICATIONS: Taken together, these data suggest that DAG production resulting from CCR2 activation is metabolised by both DAG kinase and DAG lipase pathways in monocytes and that pharmacological inhibition of DAG catabolism or application suppresses signalling on the CCL2-CCR2 axis via a mechanism dependent upon a PKC isoenzyme that is sensitive to Go6983 but not Go6976. dag 70-73 C-C motif chemokine ligand 2 Homo sapiens 285-289 31250339-6 2019 RESULTS: The kidney injury molecule-1-to-creatinine ratio (P = 0.035) and monocyte chemoattractant protein-1-to-creatinine ratio (P < 0.001) increased significantly with the increase in kidney disease severity and varied according to different albuminuria statuses and estimated glomerular-filtration rates. Creatinine 112-122 C-C motif chemokine ligand 2 Homo sapiens 74-108 31143972-8 2019 Salsalate treatment of HUVEC and THP-1 cells reduced LPS-induced phosphorylation of NFkappaB and secretion of the proinflammatory cytokines TNFalpha and MCP-1. salicylsalicylic acid 0-9 C-C motif chemokine ligand 2 Homo sapiens 153-158 31934133-9 2019 High glucose significantly evoked MV generation, which contained increased protein level of IL-6, 8 and MCP-1. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 104-109 31075639-7 2019 These measurements also verified the presence of [-CCl2-] groups and chlorine atoms on terminal carbons in highly chlorinated (>59% Cl) mixtures. Carbon 96-103 C-C motif chemokine ligand 2 Homo sapiens 51-55 31250339-7 2019 The monocyte chemoattractant protein-1-to-creatinine ratio showed a significant correlation with hemoglobin A1c (P = 0.002) and inflammatory marker levels (interleukin-6, P = 0.005; tumor necrosis factor-alpha, P < 0.001). Creatinine 42-52 C-C motif chemokine ligand 2 Homo sapiens 4-38 30868510-9 2019 Fasting plasma lactate was also positively associated with the circulating adipokines TNF-alpha and MCP-1. Lactic Acid 15-22 C-C motif chemokine ligand 2 Homo sapiens 100-105 31333667-4 2019 PolyI:C increased the expression of interferon-beta (IFN-beta), interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein (MCP-1), and interleukin-1beta (IL-1beta) in HCT116 cells, and these up-regulations were significantly altered when cells were pre-stimulated with LAB isolated from Korean fermented foods. Poly I-C 0-7 C-C motif chemokine ligand 2 Homo sapiens 142-147 31237579-1 2019 A robust fluorescent probe, MCP1, was developed for triple-detection of H2S, H2Sn and biothiols for the first time. Hydrogen Sulfide 72-75 C-C motif chemokine ligand 2 Homo sapiens 28-32 31237579-1 2019 A robust fluorescent probe, MCP1, was developed for triple-detection of H2S, H2Sn and biothiols for the first time. h2sn 77-81 C-C motif chemokine ligand 2 Homo sapiens 28-32 31237579-1 2019 A robust fluorescent probe, MCP1, was developed for triple-detection of H2S, H2Sn and biothiols for the first time. biothiols 86-95 C-C motif chemokine ligand 2 Homo sapiens 28-32 31237579-2 2019 Introduction of H2S, H2Sn and biothiols to MCP1 lead to distinct emission peaks at 508, 576 and 469 nm, respectively, enabling simultaneous detection of H2S, H2Sn and biothiols from distinct emission channels. Hydrogen Sulfide 16-19 C-C motif chemokine ligand 2 Homo sapiens 43-47 31237579-2 2019 Introduction of H2S, H2Sn and biothiols to MCP1 lead to distinct emission peaks at 508, 576 and 469 nm, respectively, enabling simultaneous detection of H2S, H2Sn and biothiols from distinct emission channels. h2sn 21-25 C-C motif chemokine ligand 2 Homo sapiens 43-47 31237579-2 2019 Introduction of H2S, H2Sn and biothiols to MCP1 lead to distinct emission peaks at 508, 576 and 469 nm, respectively, enabling simultaneous detection of H2S, H2Sn and biothiols from distinct emission channels. biothiols 30-39 C-C motif chemokine ligand 2 Homo sapiens 43-47 31237579-2 2019 Introduction of H2S, H2Sn and biothiols to MCP1 lead to distinct emission peaks at 508, 576 and 469 nm, respectively, enabling simultaneous detection of H2S, H2Sn and biothiols from distinct emission channels. Hydrogen Sulfide 21-24 C-C motif chemokine ligand 2 Homo sapiens 43-47 31237579-2 2019 Introduction of H2S, H2Sn and biothiols to MCP1 lead to distinct emission peaks at 508, 576 and 469 nm, respectively, enabling simultaneous detection of H2S, H2Sn and biothiols from distinct emission channels. h2sn 158-162 C-C motif chemokine ligand 2 Homo sapiens 43-47 31237579-2 2019 Introduction of H2S, H2Sn and biothiols to MCP1 lead to distinct emission peaks at 508, 576 and 469 nm, respectively, enabling simultaneous detection of H2S, H2Sn and biothiols from distinct emission channels. biothiols 167-176 C-C motif chemokine ligand 2 Homo sapiens 43-47 31354524-11 2019 Melatonin also counteracted the stimulatory effect of radiation on CXCL6, CCL2, ERK1, ERK2, and AKT1 mRNA expression and increased the inhibitory effect of radiation on NOS3 expression. Melatonin 0-9 C-C motif chemokine ligand 2 Homo sapiens 74-78 31354900-0 2019 Corrigendum to "Cafestol Inhibits Cyclic-Strain-Induced Interleukin-8, Intercellular Adhesion Molecule-1, and Monocyte Chemoattractant Protein-1 Production in Vascular Endothelial Cells". cafestol 16-24 C-C motif chemokine ligand 2 Homo sapiens 110-144 31339548-16 2019 Conclusions and Relevance: In this study, baseline serum levels of monocyte chemoattractant protein 1, leukemia inhibitory factor, and cluster of differentiation 152 were associated with hyperprogressive metastatic gastrointestinal cancer among patients receiving ICB. indole-2-carboxylic acid 264-267 C-C motif chemokine ligand 2 Homo sapiens 67-101 31111571-3 2019 Propagermanium (3-oxygermylpropionic acid polymer) is an organogermanium compound that is given for the treatment of hepatitis B in Japan and which inhibits the CCL2-CCR2 signaling pathway. propagermanium 0-14 C-C motif chemokine ligand 2 Homo sapiens 161-165 31022596-6 2019 RESULTS: Sal-B (10 muM) treatment significantly ameliorated LPS injury to MH7 A cells, as cell viability was increased, expression of p53 and p21 was repressed, apoptosis was inhibited, and the release of MCP-1, IL-6 and TNF-alpha was reduced. salvianolic acid B 9-14 C-C motif chemokine ligand 2 Homo sapiens 205-210 31111571-3 2019 Propagermanium (3-oxygermylpropionic acid polymer) is an organogermanium compound that is given for the treatment of hepatitis B in Japan and which inhibits the CCL2-CCR2 signaling pathway. propagermanium 16-49 C-C motif chemokine ligand 2 Homo sapiens 161-165 31111571-3 2019 Propagermanium (3-oxygermylpropionic acid polymer) is an organogermanium compound that is given for the treatment of hepatitis B in Japan and which inhibits the CCL2-CCR2 signaling pathway. organogermanium 57-72 C-C motif chemokine ligand 2 Homo sapiens 161-165 30974282-5 2019 NTD, like the CSF1R inhibitor GW2580, significantly decreased the adhesion of macrophages and production of the chemokine ligand (CCL) 2. 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine 30-36 C-C motif chemokine ligand 2 Homo sapiens 112-136 31243299-6 2019 As a result, neddylation inactivation exhibits lower chemotaxis of monocytes, thereby decreasing TAMs infiltration, which can be alleviated by CCL2 addition. tams 97-101 C-C motif chemokine ligand 2 Homo sapiens 143-147 31030090-3 2019 In this study, our findings showed that ACD treatment could reduce the high lethality rate; decrease the serum levels of alanine transaminase (ALT), aspartate aminotransferase (AST), monocyte chemoattractant protein (MCP)-1, interleukin-1beta (IL-1beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha), and ameliorate the pathological hepatic damage of ALF. atractylodin 40-43 C-C motif chemokine ligand 2 Homo sapiens 183-223 31293514-9 2019 Conclusions: This post-hoc analysis revealed that 12 weeks of atorvastatin treatment significantly decreased the markers of adipose tissue dysfunction and inflammation, namely ASP, IL-6 and MCP-1 in obese women with PCOS. Atorvastatin 62-74 C-C motif chemokine ligand 2 Homo sapiens 190-195 31289567-11 2019 In summary, the present study revealed that ketoconazole enhances GMI-inhibited proliferation and migration of A375.S2 melanoma cancer cells, and inhibits the secretion of MCP-1. Ketoconazole 44-56 C-C motif chemokine ligand 2 Homo sapiens 172-177 31243304-6 2019 Moreover, the attenuated ASC response to TNFalpha priming under smicrog was manifested in decreased production of TNFalpha-dependent pleiotropic cytokines (IL-8 and MCP-1), matrix remodeling proteases, and downregulation of some genes encoding growth factors and cytokines. smicrog 64-71 C-C motif chemokine ligand 2 Homo sapiens 165-170 31212975-11 2019 Taken together, these results provide evidence that quercetin protects ARPE-19 cells from the IL-1beta-stimulated increase in ICAM-1, sICAM-1, IL-6, IL-8 and MCP-1 production by blocking the activation of MAPK and NF-kappaB signaling pathways to ameliorate the inflammatory response. Quercetin 52-61 C-C motif chemokine ligand 2 Homo sapiens 158-163 31181818-10 2019 Peficitinib suppressed the secretion of MCP-1/CCL2 in the RA FLS supernatant (p < 0.05). peficitinib 0-11 C-C motif chemokine ligand 2 Homo sapiens 40-45 31212975-5 2019 The results showed that quercetin could dose-dependently decrease the mRNA and protein levels of ICAM-1, IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1). Quercetin 24-33 C-C motif chemokine ligand 2 Homo sapiens 120-154 31212975-5 2019 The results showed that quercetin could dose-dependently decrease the mRNA and protein levels of ICAM-1, IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1). Quercetin 24-33 C-C motif chemokine ligand 2 Homo sapiens 156-161 31212975-9 2019 U0126 and SB202190 could inhibit the expression of IL-6, IL-8 and MCP-1, but SP600125 could not. U 0126 0-5 C-C motif chemokine ligand 2 Homo sapiens 66-71 31212975-9 2019 U0126 and SB202190 could inhibit the expression of IL-6, IL-8 and MCP-1, but SP600125 could not. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 10-18 C-C motif chemokine ligand 2 Homo sapiens 66-71 31212975-10 2019 An NF-kappaB inhibitor (Bay 11-7082) also reduced the expression of ICAM-1, sICAM-1, IL-6, IL-8 and MCP-1. 3-(4-methylphenylsulfonyl)-2-propenenitrile 24-35 C-C motif chemokine ligand 2 Homo sapiens 100-105 31181818-10 2019 Peficitinib suppressed the secretion of MCP-1/CCL2 in the RA FLS supernatant (p < 0.05). peficitinib 0-11 C-C motif chemokine ligand 2 Homo sapiens 46-50 30827017-9 2019 Acarbose suppressed LPS-induced acetylation of histones H3 (H3) and H4 in the IP-10 and MCP-1 promoter regions. Acarbose 0-8 C-C motif chemokine ligand 2 Homo sapiens 88-93 30865473-6 2019 Moreover, palmitate induced gene expression (monocyte chemoattractant protein 1, matrix metalloproteinase-2, IL-1beta, IL-6, IL-8, and TNF-alpha) and intracellular protein content (plasminogen activator inhibitor-1 and urokinase plasminogen activator) of inflammatory mediators. Palmitates 10-19 C-C motif chemokine ligand 2 Homo sapiens 45-79 30466341-4 2019 Results: LPS-induced expressions of pro-inflammatory genes IL-6, IL-8, TNF-alpha, IL-1beta, MCP-1, MMP-9, iNOS and COX-2 were significantly and dose-dependently suppressed by XAV939. XAV939 175-181 C-C motif chemokine ligand 2 Homo sapiens 92-97 30827017-10 2019 These findings revealed the suppressive effects of acarbose on IP-10, MCP-1, MDC, and TNF-alpha production in THP-1 cells via, at least partially, the p38, JNK, ERK, and NF-kappaB-p65 pathways, as well as through epigenetic regulation via histone H3 and H4 acetylation. Acarbose 51-59 C-C motif chemokine ligand 2 Homo sapiens 70-75 31191554-9 2019 Chemotaxis of monocytes toward CCL2, CCL5, and CX3CL1 was increased in MS patients compared to healthy individuals and further enhanced by MP pulse therapy. Methylprednisolone 139-141 C-C motif chemokine ligand 2 Homo sapiens 31-35 31028903-5 2019 Exposure of these cells to lipogenic (insulin, glucose, fatty acids) and pro-inflammatory factors (IL-1beta, TNF-alpha, TGF-beta) resulted in a characteristic NASH response, as indicated by intracellular lipid accumulation, modulation of NASH-specific gene expression, increased caspase-3/7 activity and the expression and/or secretion of inflammatory markers, including CCL2, CCL5, CCL7, CCL8, CXCL5, CXCL8, IL1a, IL6 and IL11. Fatty Acids 56-67 C-C motif chemokine ligand 2 Homo sapiens 371-375 30910555-5 2019 Relatively high concentrations of this oxysterol markedly increased the release of pro-inflammatory interleukins 6 and 8, monocyte chemoattractant protein-1, vascular endothelial growth factor, as well as matrix metalloproteinases 2 and 9. Oxysterols 39-48 C-C motif chemokine ligand 2 Homo sapiens 122-156 31138333-7 2019 TAM generated in vitro exhibited increased transcript levels of the functional markers IL-6, IL-10, CCL2, c-Myc, iNOS, and arginase compared to in vitro generated M2-like macrophages. tam 0-3 C-C motif chemokine ligand 2 Homo sapiens 100-104 31213838-9 2019 beta-elemene could effectively suppress this recruitment phenomenon and MCP-1 expression via inhibiting Prx-1/NF-kappaB/HIF-1alpha pathways. beta-elemene 0-12 C-C motif chemokine ligand 2 Homo sapiens 72-77 31231362-9 2019 C-SVMP was able to induce increased production of the cytokines IL-1beta and IL-6 and the chemokines CXCL8/IL-8, CCL2/MCP-1, and CXCL9/MIG in the human whole blood model. c-svmp 0-6 C-C motif chemokine ligand 2 Homo sapiens 113-117 31023272-7 2019 Urinary monocyte chemoattractant protein-1 was also significantly lower in the propolis group than in the placebo group-58 pg/mg creatinine (95% CI, 36 to 95) vs. 98 pg/mg creatinine (95% CI, 62 to 155); P = 0.038. Creatinine 129-139 C-C motif chemokine ligand 2 Homo sapiens 8-42 30516070-2 2019 Monocyte chemoattractant protein (MCP)-1 and macrophage colony-stimulating factor (MCSF) stimulate monocyte migration and transition into macrophages with subsequent release of neopterin. Neopterin 177-186 C-C motif chemokine ligand 2 Homo sapiens 0-40 31058710-7 2019 Recombinant Shh could induce the CC chemokine ligand 2 (CCL2) overexpressing and Smo inhibitor GDC-O449 could inhibit CCL2 expression in airway epithelial cells, monocytes, or macrophages. gdc-o449 95-103 C-C motif chemokine ligand 2 Homo sapiens 118-122 30835899-4 2019 Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry. Iron 15-19 C-C motif chemokine ligand 2 Homo sapiens 101-105 30835899-4 2019 Treatment with iron (ferric ammonium citrate, FAC) led to increased expression levels of M1 markers: CCL2, CD14, iNOS, IL-1beta, IL-6, and TNF-alpha; it also increased protein levels of CD68, TNF-alpha, IL-1beta, and IL-6 by flow cytometry. ferric ammonium citrate 21-44 C-C motif chemokine ligand 2 Homo sapiens 101-105 31083166-5 2019 IV morphine injection reduced MCP-1 production in plasma. Morphine 3-11 C-C motif chemokine ligand 2 Homo sapiens 30-35 30951933-5 2019 Gemcitabine treatment promotes the generation of CCL2 and CCL2 could attach to C-C chemokine receptor type 2 (CCR2) to recruit M-MDSCs. gemcitabine 0-11 C-C motif chemokine ligand 2 Homo sapiens 49-53 30951933-5 2019 Gemcitabine treatment promotes the generation of CCL2 and CCL2 could attach to C-C chemokine receptor type 2 (CCR2) to recruit M-MDSCs. gemcitabine 0-11 C-C motif chemokine ligand 2 Homo sapiens 58-62 31008484-5 2019 The results showed that, PGE2 increased interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFalpha) output, decreased chemokine (c-x-c motif) ligand 8 (CXCL8) output in a dose-dependent manner, but had no effect on IL-1beta and chemokine (c-c motif) ligand 2 (CCL-2) secretion of HUSMCs. Dinoprostone 25-29 C-C motif chemokine ligand 2 Homo sapiens 122-132 31008484-5 2019 The results showed that, PGE2 increased interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFalpha) output, decreased chemokine (c-x-c motif) ligand 8 (CXCL8) output in a dose-dependent manner, but had no effect on IL-1beta and chemokine (c-c motif) ligand 2 (CCL-2) secretion of HUSMCs. Dinoprostone 25-29 C-C motif chemokine ligand 2 Homo sapiens 232-262 31008484-5 2019 The results showed that, PGE2 increased interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFalpha) output, decreased chemokine (c-x-c motif) ligand 8 (CXCL8) output in a dose-dependent manner, but had no effect on IL-1beta and chemokine (c-c motif) ligand 2 (CCL-2) secretion of HUSMCs. Dinoprostone 25-29 C-C motif chemokine ligand 2 Homo sapiens 264-269 30988769-1 2019 The present study prospectively investigated the effect of blood glucose level at admission on monocyte chemoattractant protein-1 levels at different time points before and after primary percutaneous coronary intervention, and the postoperative 1-year prognosis of patients with acute ST-segment elevation myocardial infarction. Glucose 65-72 C-C motif chemokine ligand 2 Homo sapiens 95-129 30988769-4 2019 The increase in monocyte chemoattractant protein-1 levels 24 h after percutaneous coronary intervention, compared with those before percutaneous coronary intervention, was significantly correlated with the blood glucose level at admission. Glucose 212-219 C-C motif chemokine ligand 2 Homo sapiens 16-50 31114197-8 2019 Encapsulated calcitriol diminished mRNA gene levels of TNF-, NF-B, MCP-1 and IL-6, while upregulating IL-10. Calcitriol 13-23 C-C motif chemokine ligand 2 Homo sapiens 67-72 30890405-11 2019 Pre-treatment with euxanthone markedly suppressed ox-LDL-induced ROS generation and inhibition of antioxidant enzymes, as well as the up-regulation of pro-inflammatory factors like MCP-1, IL-1beta and TNF-alpha in the HUVECs. euxanthone 19-29 C-C motif chemokine ligand 2 Homo sapiens 181-186 30826652-0 2019 A sensitive sandwich-type immunosensor for the detection of MCP-1 based on a rGO-TEPA-Thi-Au nanocomposite and novel RuPdPt trimetallic nanoalloy particles. rgo 77-80 C-C motif chemokine ligand 2 Homo sapiens 60-65 30826652-0 2019 A sensitive sandwich-type immunosensor for the detection of MCP-1 based on a rGO-TEPA-Thi-Au nanocomposite and novel RuPdPt trimetallic nanoalloy particles. Triethylenephosphoramide 81-85 C-C motif chemokine ligand 2 Homo sapiens 60-65 30826652-0 2019 A sensitive sandwich-type immunosensor for the detection of MCP-1 based on a rGO-TEPA-Thi-Au nanocomposite and novel RuPdPt trimetallic nanoalloy particles. thi-au 86-92 C-C motif chemokine ligand 2 Homo sapiens 60-65 30826652-0 2019 A sensitive sandwich-type immunosensor for the detection of MCP-1 based on a rGO-TEPA-Thi-Au nanocomposite and novel RuPdPt trimetallic nanoalloy particles. rupdpt 117-123 C-C motif chemokine ligand 2 Homo sapiens 60-65 30826652-3 2019 We obtained the excellent matrix material, which immobilized more primary antibody MCP-1-Ab1 on rGO-TEPA on a modified glassy carbon electrode (GCE). Triethylenephosphoramide 100-104 C-C motif chemokine ligand 2 Homo sapiens 83-88 30826652-3 2019 We obtained the excellent matrix material, which immobilized more primary antibody MCP-1-Ab1 on rGO-TEPA on a modified glassy carbon electrode (GCE). Carbon 126-132 C-C motif chemokine ligand 2 Homo sapiens 83-88 30826652-5 2019 RuPdPt trimetallic nanoalloy particles (RuPdPt TNPs), a novel nanomaterial, were synthesized by a one-pot method, displayed a uniform morphology as well as good electrochemical activity and bound with the secondary antibodies against MCP-1 via the Pt-NH2 bond. trimetallic 7-18 C-C motif chemokine ligand 2 Homo sapiens 234-239 30853600-6 2019 Treatment of MIN6 cells and human primary islets with palmitate increased phosphorylation of the inflammatory marker nuclear factor-kappa B (NFkappaB) and the release of pro-inflammatory cytokines including TNF and MCP-1 and decreased glucose-stimulated insulin secretion and cell viability. Palmitates 54-63 C-C motif chemokine ligand 2 Homo sapiens 215-220 30782482-9 2019 Analysis of the SMC supernatants by ELISA revealed CD-induced release of the senescence-associated cytokines IL-6 and MCP-1 in native and IFN-gamma-primed SMC, whereas no secretion of Interleukin-(IL) 1alpha and IL-1beta secretion were observed. Cadmium 51-53 C-C motif chemokine ligand 2 Homo sapiens 118-123 31258944-9 2019 Results: The baseline urinary MCP-1 levels in female patients with OAB were significantly higher than those of the controls, at a mean of 210.25 vs 48.02 pg/mg Cr (P < 0.001). Creatinine 160-162 C-C motif chemokine ligand 2 Homo sapiens 30-35 30191990-5 2019 LA, DHA, 12(S)-HETE, and RvD1 elicited mRNA expression of proinflammatory markers; tumor necrosis factor-alpha ( Tnf-alpha), interleukin 6 ( IL-6), chemokine (C-C motif) ligand 2 (Ccl2), and IL-1beta in wild type (WT) and in 12/15LOX -/- macrophages at early time point (4 hr). Docosahexaenoic Acids 4-7 C-C motif chemokine ligand 2 Homo sapiens 148-178 30933261-10 2019 Conclusions: Even though visual acuity response and anatomic effect are not always correlated in DME, we found that baseline elevated MCP-1 AH levels and DRT pattern were biomarkers that predicted a future favorable anatomic response to DEX. Dextromethorphan 237-240 C-C motif chemokine ligand 2 Homo sapiens 134-139 28992763-4 2019 RESULTS: Relative to untreated controls, OACs treated with hyperosmolar (80 mM Na+ gluconate or 160 mM sucrose) solutions produced lower levels of catabolic and inflammatory mediators in a marker- and time-dependent manner (i.e., MMP-9 after 1 day; MCP-1 after 7 days ( P <= 0.015)). oacs 41-45 C-C motif chemokine ligand 2 Homo sapiens 249-254 30203136-10 2019 GO and pathway annotation analysis for the cluster one revealed that five genes were associated with either response to dexamethasone or with lung fibrosis, including CTGF, CCL2, IGF1, EGFR and ICAM1. Dexamethasone 120-133 C-C motif chemokine ligand 2 Homo sapiens 173-177 30368911-2 2019 The monocyte chemoattractant protein-1 (MCP-1), a member of cysteine-cysteine chemokine family, plays critical roles in cancers. cysteine-cysteine 60-77 C-C motif chemokine ligand 2 Homo sapiens 4-38 30368911-2 2019 The monocyte chemoattractant protein-1 (MCP-1), a member of cysteine-cysteine chemokine family, plays critical roles in cancers. cysteine-cysteine 60-77 C-C motif chemokine ligand 2 Homo sapiens 40-45 30191990-5 2019 LA, DHA, 12(S)-HETE, and RvD1 elicited mRNA expression of proinflammatory markers; tumor necrosis factor-alpha ( Tnf-alpha), interleukin 6 ( IL-6), chemokine (C-C motif) ligand 2 (Ccl2), and IL-1beta in wild type (WT) and in 12/15LOX -/- macrophages at early time point (4 hr). Docosahexaenoic Acids 4-7 C-C motif chemokine ligand 2 Homo sapiens 181-185 30927925-13 2019 CONCLUSIONS: Our data indicates that TAMs induce EMT program to enhance CRC migration, invasion, and CTC-mediated metastasis by regulating the JAK2/STAT3/miR-506-3p/FoxQ1 axis, which in turn leads to the production of CCL2 that promote macrophage recruitment, revealing a new cross-talk between immune cells and tumor cells in CRC microenvironment. tams 37-41 C-C motif chemokine ligand 2 Homo sapiens 218-222 30569541-9 2019 Moreover, kahweol acetate and cafestol downregulated CCR2 and CCR5 without an increase in their ligands, CCL2 and CCL5. cafestol 30-38 C-C motif chemokine ligand 2 Homo sapiens 105-109 30961947-7 2019 The serum level of MCP-1 was decrease in carvacrol treated group only in the step II compared to step 0 (p < 0.05). carvacrol 41-50 C-C motif chemokine ligand 2 Homo sapiens 19-24 31167690-12 2019 Compared with the blank group, the protein levels of NF-kappaBp65, p-IkappaBalpha, IKKalpha, MCP-1 and ICAM-1 increased in the high glucose group, while the protein levels above decreased in the PDTC group compared with the high glucose group. Glucose 132-139 C-C motif chemokine ligand 2 Homo sapiens 93-98 30918802-7 2019 The concentrations of IL-6, IL-8 and MCP-1 in the culture medium reduced to 66% (for IL-6 and MCP-1) and 56% (for IL-8) of the levels without zeaxanthin. Zeaxanthins 142-152 C-C motif chemokine ligand 2 Homo sapiens 37-42 30871117-0 2019 Long-Term Exposure to Oroxylin A Inhibits Metastasis by Suppressing CCL2 in Oral Squamous Cell Carcinoma Cells. 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one 22-32 C-C motif chemokine ligand 2 Homo sapiens 68-72 30871130-10 2019 Finally, the CCL2-CCR2 axis has recently been demonstrated to be a key contributor to cabazitaxel resistance in CRPC. cabazitaxel 86-97 C-C motif chemokine ligand 2 Homo sapiens 13-17 30578392-9 2019 CONCLUSIONS: Our study reports a novel anti-angiogenesis mechanism of anlotinib via inhibiting CCL2 in an NCI-H1975-derived xenograft model and suggests that changes in serum CCL2 levels may be used to monitor and predict clinical outcomes in anlotinib-administered refractory advanced NSCLC patients using third-line therapy or beyond. anlotinib 70-79 C-C motif chemokine ligand 2 Homo sapiens 175-179 30852582-12 2019 The MCP-1 expression was positively correlated with the levels of TC, TG, and LDL in serum. Technetium 66-68 C-C motif chemokine ligand 2 Homo sapiens 4-9 30852582-12 2019 The MCP-1 expression was positively correlated with the levels of TC, TG, and LDL in serum. Triglycerides 70-72 C-C motif chemokine ligand 2 Homo sapiens 4-9 30578392-0 2019 Role of anlotinib-induced CCL2 decrease in anti-angiogenesis and response prediction for nonsmall cell lung cancer therapy. anlotinib 8-17 C-C motif chemokine ligand 2 Homo sapiens 26-30 30578392-9 2019 CONCLUSIONS: Our study reports a novel anti-angiogenesis mechanism of anlotinib via inhibiting CCL2 in an NCI-H1975-derived xenograft model and suggests that changes in serum CCL2 levels may be used to monitor and predict clinical outcomes in anlotinib-administered refractory advanced NSCLC patients using third-line therapy or beyond. anlotinib 243-252 C-C motif chemokine ligand 2 Homo sapiens 175-179 30578392-7 2019 Moreover, anlotinib inhibited angiogenesis in an NCI-H1975-derived xenograft model via inhibiting CCL2. anlotinib 10-19 C-C motif chemokine ligand 2 Homo sapiens 98-102 30639962-12 2019 In addition, pretreatment with JNK, ERK, P38, and NF-kB inhibitors could correspondingly attenuate palmitate-induced expression of VEGF, IL-6, and MCP-1. Palmitates 99-108 C-C motif chemokine ligand 2 Homo sapiens 147-152 30578392-8 2019 Finally, anlotinib-induced serum CCL2 level decreases were associated with the benefits of PFS and OS in refractory advanced NSCLC patients. anlotinib 9-18 C-C motif chemokine ligand 2 Homo sapiens 33-37 30578392-9 2019 CONCLUSIONS: Our study reports a novel anti-angiogenesis mechanism of anlotinib via inhibiting CCL2 in an NCI-H1975-derived xenograft model and suggests that changes in serum CCL2 levels may be used to monitor and predict clinical outcomes in anlotinib-administered refractory advanced NSCLC patients using third-line therapy or beyond. anlotinib 70-79 C-C motif chemokine ligand 2 Homo sapiens 95-99 30547709-5 2019 For example, the IP agonist cicaprost stimulated VEGF secretion although it inhibits monocyte chemoattractant protein-1 (MCP-1) secretion: both would favor a proangiogenic effect. cicaprost 28-37 C-C motif chemokine ligand 2 Homo sapiens 85-119 30519866-7 2019 Our data show that dopamine treatment of human macrophages isolated from healthy and cART-treated donors promotes production of inflammatory mediators including IL-1beta, IL-6, IL-18, CCL2, CXCL8, CXCL9, and CXCL10. Dopamine 19-27 C-C motif chemokine ligand 2 Homo sapiens 184-188 30547709-5 2019 For example, the IP agonist cicaprost stimulated VEGF secretion although it inhibits monocyte chemoattractant protein-1 (MCP-1) secretion: both would favor a proangiogenic effect. cicaprost 28-37 C-C motif chemokine ligand 2 Homo sapiens 121-126 30543876-6 2019 Effects of BA on TNF- and LPS-induced MCP-1 secretion and lipolysis were analyzed. Bile Acids and Salts 11-13 C-C motif chemokine ligand 2 Homo sapiens 38-43 30543876-11 2019 Importantly, TNF- and LPS-induced MCP-1 release from adipocytes as well as TNF-induced lipolysis can be antagonized by cholic acid (CA) and deoxycholic acid (DCA). Cholic Acid 119-130 C-C motif chemokine ligand 2 Homo sapiens 34-39 30543876-11 2019 Importantly, TNF- and LPS-induced MCP-1 release from adipocytes as well as TNF-induced lipolysis can be antagonized by cholic acid (CA) and deoxycholic acid (DCA). Deoxycholic Acid 140-156 C-C motif chemokine ligand 2 Homo sapiens 34-39 30543876-11 2019 Importantly, TNF- and LPS-induced MCP-1 release from adipocytes as well as TNF-induced lipolysis can be antagonized by cholic acid (CA) and deoxycholic acid (DCA). Deoxycholic Acid 158-161 C-C motif chemokine ligand 2 Homo sapiens 34-39 30543876-12 2019 CONCLUSIONS: The present data provide evidence of functional BA signaling pathways in adipocytes and argue for certain MCP-1 related anti-inflammatory effects of BA in TNF- and LPS-induced inflammation, whereas pro-inflammatory resistin is induced by CA and glycocholic acid (GCA). Bile Acids and Salts 162-164 C-C motif chemokine ligand 2 Homo sapiens 119-124 30287151-5 2019 Mechanistic studies reveal that pathways relevant to inflammation participate in the pathogenesis of DN, however, consumption of vitamin D-related products negatively regulates inflammatory response at multiple levels, indicated by inhibiting macrophage infiltration, nuclear factor-kappa B (NF-kappaB) activation, and production of such inflammatory mediators as transforming growth factor-beta(TGF-beta), monocyte chemoattractant protein 1(MCP-1), and regulated upon activation normal T cell expressed and secreted protein(RANTES). Vitamin D 129-138 C-C motif chemokine ligand 2 Homo sapiens 407-441 30899375-9 2019 Moreover, CCR4 knockdown, U0126 (a MEK/ERK inhibitor) or ophiopogonin B also partially blocked the EMT promoting effects of CCL2 and CCL5. U 0126 26-31 C-C motif chemokine ligand 2 Homo sapiens 124-128 31037275-7 2019 Results: TCJ significantly reduced sUA concentration by 19.2% (P < 0.05) and reduced by 19.4% (P = 0.09) and 6.3% (P = 0.08) proinflammatory high-sensitivity C-reactive protein and monocyte chemoattractant protein-1, respectively. tcj 9-12 C-C motif chemokine ligand 2 Homo sapiens 184-218 30842737-10 2019 GYY4137 and ATB-346 significantly reduced the IM-induced increase in muscular myeloperoxidase (MPO) activity and protein levels of interleukin (IL)-6, IL-1beta and monocyte chemotactic protein 1; the reduction by naproxen was less pronounced and only reached significance for MPO activity and IL-6 levels. GYY 4137 0-7 C-C motif chemokine ligand 2 Homo sapiens 164-194 30842737-10 2019 GYY4137 and ATB-346 significantly reduced the IM-induced increase in muscular myeloperoxidase (MPO) activity and protein levels of interleukin (IL)-6, IL-1beta and monocyte chemotactic protein 1; the reduction by naproxen was less pronounced and only reached significance for MPO activity and IL-6 levels. 4-anisyltetrazolium blue 12-15 C-C motif chemokine ligand 2 Homo sapiens 164-194 30287151-5 2019 Mechanistic studies reveal that pathways relevant to inflammation participate in the pathogenesis of DN, however, consumption of vitamin D-related products negatively regulates inflammatory response at multiple levels, indicated by inhibiting macrophage infiltration, nuclear factor-kappa B (NF-kappaB) activation, and production of such inflammatory mediators as transforming growth factor-beta(TGF-beta), monocyte chemoattractant protein 1(MCP-1), and regulated upon activation normal T cell expressed and secreted protein(RANTES). Vitamin D 129-138 C-C motif chemokine ligand 2 Homo sapiens 442-447 30792750-12 2019 In the water phase, the level of MCP-1 was significantly decreased, while all of the other factors increased during the 4th through 6th months. Water 7-12 C-C motif chemokine ligand 2 Homo sapiens 33-38 30428424-8 2019 RESULTS: Incubation with EPA and/or DHA attenuated inflammatory response to lipopolysaccharide (LPS) and monocyte co-culture with reduction in post-LPS mRNA expression and protein levels of IL6, CCL2 and CX3CL1. Eicosapentaenoic Acid 25-28 C-C motif chemokine ligand 2 Homo sapiens 195-199 30550941-6 2019 The immunomodulatory drug lenalidomide had direct anti-proliferative effect on activated B-cell like DLBCL spheroids and reduced several cytokines and other markers (e.g., CCL2, CCL3, CCL4, CD137 and ANG-1 levels) compared with untreated spheroids. Lenalidomide 26-38 C-C motif chemokine ligand 2 Homo sapiens 172-176 30315526-14 2019 Catalpol reduced HCY-stimulated ROS over-generation, inhibited the NF-kappaB transcriptional activation as well as the protein over-expressions of Nox4, ICAM-1, VCAM-1, and MCP-1. Homocysteine 17-20 C-C motif chemokine ligand 2 Homo sapiens 173-178 30863452-6 2019 Systematic analysis of the created TCMP-Compound-Target-Disease network revealed that DHI and NXT shared common targets such as PTGS2, F2, ADRB1, IL6, ALDH2, and CCL2, which were involved in the vasomotor system regulation, blood-brain barrier disruption, redox imbalance, neurotrophin activity, and brain inflammation. TCMP 35-39 C-C motif chemokine ligand 2 Homo sapiens 162-166 30863452-6 2019 Systematic analysis of the created TCMP-Compound-Target-Disease network revealed that DHI and NXT shared common targets such as PTGS2, F2, ADRB1, IL6, ALDH2, and CCL2, which were involved in the vasomotor system regulation, blood-brain barrier disruption, redox imbalance, neurotrophin activity, and brain inflammation. dehydrosoyasaponin I 86-89 C-C motif chemokine ligand 2 Homo sapiens 162-166 30392853-5 2019 In addition, the glucan induced a tendency to increase the secreted levels of the anti-inflammatory cytokine IL-10, enhanced the expression levels of CCL2 and CCL8 mRNAs, and inhibited expression of CCR2 mRNA in the IFNgamma/LPS activated macrophages. Glucans 17-23 C-C motif chemokine ligand 2 Homo sapiens 150-154 30428424-8 2019 RESULTS: Incubation with EPA and/or DHA attenuated inflammatory response to lipopolysaccharide (LPS) and monocyte co-culture with reduction in post-LPS mRNA expression and protein levels of IL6, CCL2 and CX3CL1. Docosahexaenoic Acids 36-39 C-C motif chemokine ligand 2 Homo sapiens 195-199 30531622-8 2019 Through this analysis, the authors found a set of genes, including YAP1 and CCL-2, whose expression changes predict 5-fluorouracil therapy status and include genes that have not previously been associated with keloid biology and are of unknown function. Fluorouracil 116-130 C-C motif chemokine ligand 2 Homo sapiens 76-81 30030777-7 2019 MCP-1 secretion was suppressed by nicotine, alone and together with Pg LPS, while 4-NQO activated its secretion. Nicotine 34-42 C-C motif chemokine ligand 2 Homo sapiens 0-5 30535458-7 2019 Moreover, the level of urinary monocyte chemoattractant protein-1 (u-MCP-1) was increased in the participants with obesity, and it was positively correlated with free fatty acid (FFA), UACR and u-NGAL. Fatty Acids, Nonesterified 162-177 C-C motif chemokine ligand 2 Homo sapiens 31-65 30535458-7 2019 Moreover, the level of urinary monocyte chemoattractant protein-1 (u-MCP-1) was increased in the participants with obesity, and it was positively correlated with free fatty acid (FFA), UACR and u-NGAL. Fatty Acids, Nonesterified 162-177 C-C motif chemokine ligand 2 Homo sapiens 69-74 30535458-7 2019 Moreover, the level of urinary monocyte chemoattractant protein-1 (u-MCP-1) was increased in the participants with obesity, and it was positively correlated with free fatty acid (FFA), UACR and u-NGAL. Fatty Acids, Nonesterified 179-182 C-C motif chemokine ligand 2 Homo sapiens 31-65 30535458-7 2019 Moreover, the level of urinary monocyte chemoattractant protein-1 (u-MCP-1) was increased in the participants with obesity, and it was positively correlated with free fatty acid (FFA), UACR and u-NGAL. Fatty Acids, Nonesterified 179-182 C-C motif chemokine ligand 2 Homo sapiens 69-74 30804705-7 2019 Results: Theobromine significantly inhibits the differentiation of preadipocytes in mature adipocytes and reduces the levels of proinflammatory cytokines as MCP-1 and IL-1beta in the supernatants obtained by the mature adipocytes and macrophages interaction. Theobromine 9-20 C-C motif chemokine ligand 2 Homo sapiens 157-162 30315378-8 2019 RESULTS: Administration of vinpocetine reduced mRNA levels of TLR2/4, as well as protein levels of the downstream signalling molecules, MyD88 and NF-kappaB; moreover, it lowered the expression levels of serum inflammatory cytokines, TNF-alpha and MCP-1. vinpocetine 27-38 C-C motif chemokine ligand 2 Homo sapiens 247-252 30634931-13 2019 The increased renal protein or mRNA of TLR4 and proinflammatory mediators (IL-6 and MCP-1) in the unpretreated animals was significantly attenuated in the norfloxacin-pretreated animals. Norfloxacin 155-166 C-C motif chemokine ligand 2 Homo sapiens 84-89 30426599-9 2019 The stimulation of DU145 cells with CCL2 increased the proliferation rate under treatments with cabazitaxel, and a CCR2 (a specific receptor of CCL2) antagonist suppressed the proliferation of DU145-TxR and DU145-TxR/CxR cells under treatments of cabazitaxel. cabazitaxel 247-258 C-C motif chemokine ligand 2 Homo sapiens 144-148 30426599-11 2019 CCL2 is apparently a key contributor to cabazitaxel resistance in prostate cancer cells. cabazitaxel 40-51 C-C motif chemokine ligand 2 Homo sapiens 0-4 30426599-12 2019 Inhibition of the CCL2-CCR2 axis may be a potential therapeutic strategy against chemoresistant CRPC in combination with cabazitaxel. cabazitaxel 121-132 C-C motif chemokine ligand 2 Homo sapiens 18-22 31029854-10 2019 Doxycycline-induced tetNGN3-HIEs secreted serotonin, monocyte chemoattractant protein-1, glucose-dependent insulinotropic peptide, peptide YY, and ghrelin in response to norepinephrine and rotavirus infection, further supporting the presence of multiple EEC types. Doxycycline 0-11 C-C motif chemokine ligand 2 Homo sapiens 53-87 31029854-10 2019 Doxycycline-induced tetNGN3-HIEs secreted serotonin, monocyte chemoattractant protein-1, glucose-dependent insulinotropic peptide, peptide YY, and ghrelin in response to norepinephrine and rotavirus infection, further supporting the presence of multiple EEC types. Norepinephrine 170-184 C-C motif chemokine ligand 2 Homo sapiens 53-87 30246883-7 2019 RESULTS: Vitamin D supplementation resulted in significant increase of serum 25OHD level (P < 0.001), and significant decrease in PTH (P < 0.001), MCP-1 (P < 0.05), IL-1beta (P < 0.05) and TLR-4 (P < 0.05); compared to the baseline values in vitamin D group. Vitamin D 9-18 C-C motif chemokine ligand 2 Homo sapiens 147-152 30246883-10 2019 CONCLUSIONS: Improvement in vitamin D status in obese subjects with vitamin D deficiency in combination with weight loss diet resulted in weight, fat mass and MCP-1 decrease. Vitamin D 28-37 C-C motif chemokine ligand 2 Homo sapiens 159-164 30246883-10 2019 CONCLUSIONS: Improvement in vitamin D status in obese subjects with vitamin D deficiency in combination with weight loss diet resulted in weight, fat mass and MCP-1 decrease. Vitamin D 68-77 C-C motif chemokine ligand 2 Homo sapiens 159-164 30818187-7 2019 The cells pretreated with SAHA showed enhanced expression of the many adipogenic genes, including peroxisome proliferator-activated receptor-gamma as well as the accumulation of intracytoplasmic fat as shown by oil red and Nile red staining and the secretion of adipokines, such as MCP-1 and IP-10. Vorinostat 26-30 C-C motif chemokine ligand 2 Homo sapiens 282-287 30426599-0 2019 CCL2 induces resistance to the antiproliferative effect of cabazitaxel in prostate cancer cells. cabazitaxel 59-70 C-C motif chemokine ligand 2 Homo sapiens 0-4 30426599-9 2019 The stimulation of DU145 cells with CCL2 increased the proliferation rate under treatments with cabazitaxel, and a CCR2 (a specific receptor of CCL2) antagonist suppressed the proliferation of DU145-TxR and DU145-TxR/CxR cells under treatments of cabazitaxel. cabazitaxel 96-107 C-C motif chemokine ligand 2 Homo sapiens 36-40 31345146-10 2019 RESULTS: Compared with control group, the folic acid plus vitamin B 12 group had significantly greater improvements in serum folate, homocysteine, vitamin B 12 and IL-6, TNF-alpha, MCP-1. Folic Acid 42-52 C-C motif chemokine ligand 2 Homo sapiens 181-186 31345146-10 2019 RESULTS: Compared with control group, the folic acid plus vitamin B 12 group had significantly greater improvements in serum folate, homocysteine, vitamin B 12 and IL-6, TNF-alpha, MCP-1. Vitamin B 12 58-70 C-C motif chemokine ligand 2 Homo sapiens 181-186 31425951-0 2019 Effects of vitamin D supplementation on circulatory YKL-40 and MCP-1 biomarkers associated with vascular diabetic complications: A randomized, placebo-controlled, double-blind clinical trial. Vitamin D 11-20 C-C motif chemokine ligand 2 Homo sapiens 63-68 31425951-5 2019 Therefore, this study was designed to investigate effects of vitamin D supplementation on serum levels of YKL-40 and MCP-1 involved in the development of diabetic complications. Vitamin D 61-70 C-C motif chemokine ligand 2 Homo sapiens 117-122 31425951-12 2019 CONCLUSIONS: Daily vitamin D supplementation effectively reduced circulatory YKL-40 and MCP-1 levels in patients with type-2 diabetes and vitamin D deficiency. Vitamin D 19-28 C-C motif chemokine ligand 2 Homo sapiens 88-93 31425951-12 2019 CONCLUSIONS: Daily vitamin D supplementation effectively reduced circulatory YKL-40 and MCP-1 levels in patients with type-2 diabetes and vitamin D deficiency. Vitamin D 138-147 C-C motif chemokine ligand 2 Homo sapiens 88-93 31425951-13 2019 Vitamin D might contribute in reducing diabetic complications via modulating YKL-40 and MCP-1 signaling pathways. Vitamin D 0-9 C-C motif chemokine ligand 2 Homo sapiens 88-93 30366059-5 2019 Induction of an inflammatory response was observed after LPS treatment and the addition of RESV led to decreases in expression of the inflammatory mediators, tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), and monocyte chemoattractant protein-1 (MCP-1), without cytotoxicity. Resveratrol 91-95 C-C motif chemokine ligand 2 Homo sapiens 225-259 30366059-5 2019 Induction of an inflammatory response was observed after LPS treatment and the addition of RESV led to decreases in expression of the inflammatory mediators, tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), and monocyte chemoattractant protein-1 (MCP-1), without cytotoxicity. Resveratrol 91-95 C-C motif chemokine ligand 2 Homo sapiens 261-266 30471617-14 2019 In Mrgprx2 knockdown LAD2 cells, the effect of Quercetin (200 muM) reduced C48/80 induced calcium flux and the release of beta-hexosaminidase, histamine, MCP-1 and IL-8 compared with non-atopic control (NC) transfected LAD2 human mast cells, suggesting that Quercetin anti-pseudo-allergic effect was related to Mrgprx2. Quercetin 47-56 C-C motif chemokine ligand 2 Homo sapiens 154-159 31418610-3 2019 Relapsed DME cases (T3) showed significantly higher levels of IL-6 (p = .028), IL-8 (p = .005), IP-10 (p = .013) and MCP-1 (p = .005) compared to T2.Conclusion: IP-10 and MCP-1 AH levels seem to be related to DEX intraocular action, decreasing after injection and increasing when DME relapses. dme 9-12 C-C motif chemokine ligand 2 Homo sapiens 117-122 31418610-3 2019 Relapsed DME cases (T3) showed significantly higher levels of IL-6 (p = .028), IL-8 (p = .005), IP-10 (p = .013) and MCP-1 (p = .005) compared to T2.Conclusion: IP-10 and MCP-1 AH levels seem to be related to DEX intraocular action, decreasing after injection and increasing when DME relapses. dme 9-12 C-C motif chemokine ligand 2 Homo sapiens 171-176 30568593-0 2018 TAK-442, a Direct Factor Xa Inhibitor, Inhibits Monocyte Chemoattractant Protein 1 Production in Endothelial Cells via Involvement of Protease-Activated Receptor 1. 1-(1-(3-((6-chloronaphthalen-2-yl)sulfonyl)-2-hydroxypropanoyl)piperidin-4-yl)tetrahydropyrimidin-2(1H)-one 0-7 C-C motif chemokine ligand 2 Homo sapiens 48-82 30472461-7 2019 Recent evidence indicates that alcohol exposure increased the activity of MCP-1/CCR2 in both mature and developing central nervous systems (CNS). Alcohols 31-38 C-C motif chemokine ligand 2 Homo sapiens 74-79 30472461-8 2019 MCP-1/CCR2 signaling in the brain was involved in alcohol drinking behavior. Alcohols 50-57 C-C motif chemokine ligand 2 Homo sapiens 0-5 30472461-9 2019 MCP-1/CCR2 inhibition alleviated alcohol neurotoxicity by reducing microglia activation/neuroinflammation in the developing brain and spinal cord. Alcohols 33-40 C-C motif chemokine ligand 2 Homo sapiens 0-5 30472461-10 2019 In this review, we discussed the role of MCP-1/CCR2 signaling in alcohol-induced neuroinflammation and brain damage. Alcohols 65-72 C-C motif chemokine ligand 2 Homo sapiens 41-46 30472461-11 2019 We also discussed the signaling cascades that are involved in the activation of MCP-1/CCR2 in response to alcohol exposure. Alcohols 106-113 C-C motif chemokine ligand 2 Homo sapiens 80-85 31665737-17 2019 In patients with IIP, the serum levels of KL-6, SP-A, CCL2, and CXCL13 all showed a significant negative correlation with the diffusing capacity of the lungs for carbon monoxide (DLCO; r = -0.36, -0.37, -0.36, -0.30, respectively; all p < 0.05). Carbon Monoxide 162-177 C-C motif chemokine ligand 2 Homo sapiens 54-58 30643045-5 2018 ATP at low concentration (5 mumol/L) significantly inhibited LPS-induced mRNA expression of IL-1beta, MCP-1 and ICAM-1(P<0.05), downregulated the LPS-induced protein expression of TLR4, MyD88 and CD14 in EPCs (P<0.05), and suppressed LPS-induced activation of NF-kappaB signaling pathway (P<0.05). Adenosine Triphosphate 0-3 C-C motif chemokine ligand 2 Homo sapiens 102-107 30585203-10 2018 Treatment with the pharmacological PKCdelta inhibitor; rottlerin, effectively blocked the enhanced productions of ICAM1 and CCL2. rottlerin 55-64 C-C motif chemokine ligand 2 Homo sapiens 124-128 30568593-4 2018 In human umbilical vein endothelial cells, FXa-increased production of monocyte chemoattractant protein 1 (MCP-1), a key inflammatory mediator, was inhibited by TAK-442 but not melagatran, and was also remarkably suppressed by vorapaxar. vorapaxar 227-236 C-C motif chemokine ligand 2 Homo sapiens 71-105 30568593-4 2018 In human umbilical vein endothelial cells, FXa-increased production of monocyte chemoattractant protein 1 (MCP-1), a key inflammatory mediator, was inhibited by TAK-442 but not melagatran, and was also remarkably suppressed by vorapaxar. vorapaxar 227-236 C-C motif chemokine ligand 2 Homo sapiens 107-112 30568593-4 2018 In human umbilical vein endothelial cells, FXa-increased production of monocyte chemoattractant protein 1 (MCP-1), a key inflammatory mediator, was inhibited by TAK-442 but not melagatran, and was also remarkably suppressed by vorapaxar. 1-(1-(3-((6-chloronaphthalen-2-yl)sulfonyl)-2-hydroxypropanoyl)piperidin-4-yl)tetrahydropyrimidin-2(1H)-one 161-168 C-C motif chemokine ligand 2 Homo sapiens 71-105 30568593-6 2018 We therefore confirmed the inhibitory effect of TAK-442 in endothelial MCP-1 production and the PAR1 intervention in the response. 1-(1-(3-((6-chloronaphthalen-2-yl)sulfonyl)-2-hydroxypropanoyl)piperidin-4-yl)tetrahydropyrimidin-2(1H)-one 48-55 C-C motif chemokine ligand 2 Homo sapiens 71-76 30568593-4 2018 In human umbilical vein endothelial cells, FXa-increased production of monocyte chemoattractant protein 1 (MCP-1), a key inflammatory mediator, was inhibited by TAK-442 but not melagatran, and was also remarkably suppressed by vorapaxar. 1-(1-(3-((6-chloronaphthalen-2-yl)sulfonyl)-2-hydroxypropanoyl)piperidin-4-yl)tetrahydropyrimidin-2(1H)-one 161-168 C-C motif chemokine ligand 2 Homo sapiens 107-112 29790294-10 2018 Tofacitinib inhibited the effect of oncostatin M (OSM) on interleukin-6 (IL-6) and monocyte chemotactic protein 1 and reversed the effects of OSM on RASF cellular metabolism. tofacitinib 0-11 C-C motif chemokine ligand 2 Homo sapiens 83-113 30372883-6 2018 Vildagliptin potently suppresses high glucose-induced generation of reactive oxygen species (ROS) and production of vascular inflammatory factors including tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), intercellular cell adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein 1 (MCP-1). Vildagliptin 0-12 C-C motif chemokine ligand 2 Homo sapiens 271-301 30372883-6 2018 Vildagliptin potently suppresses high glucose-induced generation of reactive oxygen species (ROS) and production of vascular inflammatory factors including tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), intercellular cell adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein 1 (MCP-1). Glucose 38-45 C-C motif chemokine ligand 2 Homo sapiens 303-308 30372883-6 2018 Vildagliptin potently suppresses high glucose-induced generation of reactive oxygen species (ROS) and production of vascular inflammatory factors including tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), intercellular cell adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein 1 (MCP-1). Vildagliptin 0-12 C-C motif chemokine ligand 2 Homo sapiens 303-308 30372883-6 2018 Vildagliptin potently suppresses high glucose-induced generation of reactive oxygen species (ROS) and production of vascular inflammatory factors including tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), intercellular cell adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein 1 (MCP-1). Glucose 38-45 C-C motif chemokine ligand 2 Homo sapiens 271-301 29791013-0 2018 Frontline Science: Buprenorphine decreases CCL2-mediated migration of CD14+ CD16+ monocytes. Buprenorphine 19-32 C-C motif chemokine ligand 2 Homo sapiens 43-47 30073566-0 2018 Hyperbaric Oxygen Alleviates the Inflammatory Response Induced by LPS Through Inhibition of NF-kappaB/MAPKs-CCL2/CXCL1 Signaling Pathway in Cultured Astrocytes. Oxygen 11-17 C-C motif chemokine ligand 2 Homo sapiens 108-112 30073566-6 2018 Inhibitors of NF-kappaB, ERK, and JNK (BAY117082, PD98059, and SP600125) significantly suppressed the expression of CXCL1 and CCL2 that were induced by LPS for 3 h. However, the p38 inhibitor, SB203580, had no obvious effect on expression levels of CXCL1 and CCL2. 3-(4-methylphenylsulfonyl)-2-propenenitrile 39-48 C-C motif chemokine ligand 2 Homo sapiens 126-130 30073566-6 2018 Inhibitors of NF-kappaB, ERK, and JNK (BAY117082, PD98059, and SP600125) significantly suppressed the expression of CXCL1 and CCL2 that were induced by LPS for 3 h. However, the p38 inhibitor, SB203580, had no obvious effect on expression levels of CXCL1 and CCL2. 3-(4-methylphenylsulfonyl)-2-propenenitrile 39-48 C-C motif chemokine ligand 2 Homo sapiens 259-263 30073566-6 2018 Inhibitors of NF-kappaB, ERK, and JNK (BAY117082, PD98059, and SP600125) significantly suppressed the expression of CXCL1 and CCL2 that were induced by LPS for 3 h. However, the p38 inhibitor, SB203580, had no obvious effect on expression levels of CXCL1 and CCL2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-57 C-C motif chemokine ligand 2 Homo sapiens 126-130 30073566-6 2018 Inhibitors of NF-kappaB, ERK, and JNK (BAY117082, PD98059, and SP600125) significantly suppressed the expression of CXCL1 and CCL2 that were induced by LPS for 3 h. However, the p38 inhibitor, SB203580, had no obvious effect on expression levels of CXCL1 and CCL2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-57 C-C motif chemokine ligand 2 Homo sapiens 259-263 30073566-6 2018 Inhibitors of NF-kappaB, ERK, and JNK (BAY117082, PD98059, and SP600125) significantly suppressed the expression of CXCL1 and CCL2 that were induced by LPS for 3 h. However, the p38 inhibitor, SB203580, had no obvious effect on expression levels of CXCL1 and CCL2. pyrazolanthrone 63-71 C-C motif chemokine ligand 2 Homo sapiens 126-130 30073566-6 2018 Inhibitors of NF-kappaB, ERK, and JNK (BAY117082, PD98059, and SP600125) significantly suppressed the expression of CXCL1 and CCL2 that were induced by LPS for 3 h. However, the p38 inhibitor, SB203580, had no obvious effect on expression levels of CXCL1 and CCL2. pyrazolanthrone 63-71 C-C motif chemokine ligand 2 Homo sapiens 259-263 30073566-6 2018 Inhibitors of NF-kappaB, ERK, and JNK (BAY117082, PD98059, and SP600125) significantly suppressed the expression of CXCL1 and CCL2 that were induced by LPS for 3 h. However, the p38 inhibitor, SB203580, had no obvious effect on expression levels of CXCL1 and CCL2. SB 203580 193-201 C-C motif chemokine ligand 2 Homo sapiens 126-130 29791013-9 2018 The effects of buprenorphine on CCL2-mediated CD14+ CD16+ monocytes transmigration across the BBB, a critical mechanism that promotes neuroinflammation and HAND, have not been characterized. Buprenorphine 15-28 C-C motif chemokine ligand 2 Homo sapiens 32-36 29791013-10 2018 We showed for the first time that buprenorphine decreases several steps of CCL2-mediated human mature monocyte transmigration. Buprenorphine 34-47 C-C motif chemokine ligand 2 Homo sapiens 75-79 30165193-7 2018 Among these cytokines increased in conditioned media of co-cultured cells, CCL2 was secreted from TAMs, leading to induction of ERO1-alpha, MMP-9 upregulation, and invasiveness in MCF10A cells. tams 98-102 C-C motif chemokine ligand 2 Homo sapiens 75-79 30244119-9 2018 Finally, capsaicin (<=125 muM) significantly increased lipopolysaccharide-stimulated IL-6 and TNF-alpha release from THP-1 cells, whereas phytohaemagglutinin-stimulated IL-1beta, TNF-alpha, MCP-1 and IL-6 release were concentration-dependently inhibited by capsaicin. Capsaicin 9-18 C-C motif chemokine ligand 2 Homo sapiens 193-198 30463189-3 2018 The results showed that COS pretreatment for 12 h significantly ameliorated lipid accumulation in HepG2 cells exposed to PA for 24 h, accompanied by a reversing of the upregulated mRNA expression of proinflammatory cytokines (IL-6, MCP-1, TNF-alpha) and glucolipid metabolism-related regulators (SCD-1, ACC1, PCK1-alpha). carbonyl sulfide 24-27 C-C motif chemokine ligand 2 Homo sapiens 232-237 30463189-3 2018 The results showed that COS pretreatment for 12 h significantly ameliorated lipid accumulation in HepG2 cells exposed to PA for 24 h, accompanied by a reversing of the upregulated mRNA expression of proinflammatory cytokines (IL-6, MCP-1, TNF-alpha) and glucolipid metabolism-related regulators (SCD-1, ACC1, PCK1-alpha). Palmitic Acid 121-123 C-C motif chemokine ligand 2 Homo sapiens 232-237 30458886-9 2018 IGF-1R inhibition in tumor epithelial cells elevated interleukin (IL)-6 and C-C motif chemokine ligand 2 (CCL2) expression, which was reversed by ROS scavenging. Reactive Oxygen Species 146-149 C-C motif chemokine ligand 2 Homo sapiens 76-104 30458886-9 2018 IGF-1R inhibition in tumor epithelial cells elevated interleukin (IL)-6 and C-C motif chemokine ligand 2 (CCL2) expression, which was reversed by ROS scavenging. Reactive Oxygen Species 146-149 C-C motif chemokine ligand 2 Homo sapiens 106-110 30354123-6 2018 A lead methylidene (CCl2-PbCl2) was identified only in reactions with CCl4. methylidene 7-18 C-C motif chemokine ligand 2 Homo sapiens 20-24 30354123-8 2018 In this case Pb uses three p orbitals in bonding and C is sp2 hybridized leaving spin paired but not bonding by symmetry single electrons in the C 2p orbital perpendicular to the CCl2 plane and in the Pb 6s orbital. Lead 13-15 C-C motif chemokine ligand 2 Homo sapiens 179-183 30418988-3 2018 MCP-1 activation can be reversed by application of rosiglitazone (thiazolidinedione). Rosiglitazone 51-64 C-C motif chemokine ligand 2 Homo sapiens 0-5 30466970-13 2018 The down-regulation of MCP-1 mRNA induced by coronopilin and damsin was confirmed on the protein level. coronopilin 45-56 C-C motif chemokine ligand 2 Homo sapiens 23-28 30418988-3 2018 MCP-1 activation can be reversed by application of rosiglitazone (thiazolidinedione). 2,4-thiazolidinedione 66-83 C-C motif chemokine ligand 2 Homo sapiens 0-5 30418988-5 2018 We hypothesized that vascular remodeling and MCP-1 activation is accompanied by pulmonary influx of fetal monocytes and can be attenuated by prenatal treatment with rosiglitazone. Rosiglitazone 165-178 C-C motif chemokine ligand 2 Homo sapiens 45-50 30418988-14 2018 CONCLUSION: Prenatal treatment with rosiglitazone has the potential to attenuate activation of pulmonary MCP-1, pulmonary monocyte influx, and vascular remodeling in experimental CDH. Rosiglitazone 36-49 C-C motif chemokine ligand 2 Homo sapiens 105-110 30295964-4 2018 RESULTS: Poly (I:C) induced the expression of the interferon-stimulated genes (ISG) MxA, OAS2 and APOBEC3G, and the cytokines MCP-1, IL-8, IL-6, CCL20, IFNbeta and RANTES by fibroblasts from all three sites. Poly I-C 9-19 C-C motif chemokine ligand 2 Homo sapiens 126-131 30400326-4 2018 Exposing monocytes to CaP-CHI-HA resulted in a secretion of pro-healing VEGF and TGF-beta growth factors, TNF-alpha, MCP-1, IL-6 and IL-8 pro-inflammatory mediators but also IL-10 anti-inflammatory cytokine along with an inflammatory index below 1.5 (versus 2.5 and 7.5 following CaP and LPS stimulation, respectively). cap 22-25 C-C motif chemokine ligand 2 Homo sapiens 117-122 29939445-14 2018 Ruxolitinib also significantly inhibited the production of IL-6, TNF-alpha and MCP-1 as induced by A23817 and substance P. Selective STAT5 inhibition with pimozide resulted in diminished degranulation and inhibition of cytokine production as induced by A23817 and substance P. CONCLUSIONS & CLINICAL RELEVANCE: This study demonstrates that the JAK1/JAK2 inhibitor ruxolitinib can inhibit MCactivity, possibly through prevention of STAT5 activation. ruxolitinib 0-11 C-C motif chemokine ligand 2 Homo sapiens 79-84 29939445-14 2018 Ruxolitinib also significantly inhibited the production of IL-6, TNF-alpha and MCP-1 as induced by A23817 and substance P. Selective STAT5 inhibition with pimozide resulted in diminished degranulation and inhibition of cytokine production as induced by A23817 and substance P. CONCLUSIONS & CLINICAL RELEVANCE: This study demonstrates that the JAK1/JAK2 inhibitor ruxolitinib can inhibit MCactivity, possibly through prevention of STAT5 activation. Pimozide 155-163 C-C motif chemokine ligand 2 Homo sapiens 79-84 29939445-14 2018 Ruxolitinib also significantly inhibited the production of IL-6, TNF-alpha and MCP-1 as induced by A23817 and substance P. Selective STAT5 inhibition with pimozide resulted in diminished degranulation and inhibition of cytokine production as induced by A23817 and substance P. CONCLUSIONS & CLINICAL RELEVANCE: This study demonstrates that the JAK1/JAK2 inhibitor ruxolitinib can inhibit MCactivity, possibly through prevention of STAT5 activation. a23817 99-105 C-C motif chemokine ligand 2 Homo sapiens 79-84 29630425-8 2018 RESULTS: Metformin suppressed LPS-induced IP-10 and MCP-1 production as well as LPS-induced phosphorylation of c-Jun N-terminal kinase (JNK), p38, extracellular signal-regulated kinase (ERK), and nuclear factor-kappa B (NF-kappaB). Metformin 9-18 C-C motif chemokine ligand 2 Homo sapiens 52-57 30192415-4 2018 Minocycline decreased the production of CCL22, CCL24 and CCL26 as well as CCL2 from M2 macrophages. Minocycline 0-11 C-C motif chemokine ligand 2 Homo sapiens 40-44 30255184-7 2018 The chemokine MCP-1 and cytokine TNF-alpha were lower in participants after consuming TCJ compared to those consuming the placebo beverage. tcj 86-89 C-C motif chemokine ligand 2 Homo sapiens 14-19 30274681-8 2018 In vitro, the sodium chloride concentration dose-dependently increased monocyte chemotactic cytokine CCL2 production in human myeloid and renal tubular epithelial cells. Sodium Chloride 14-29 C-C motif chemokine ligand 2 Homo sapiens 101-105 29777718-5 2018 Similarly, LTBI with LBMI is also characterized by diminished TB-antigen stimulated levels of CCL1, CCL2, CCL3, CCL4, CCL11, CXCL1, CXCL2, CXCL9, CXCL10 and CXCL11. Terbium 12-14 C-C motif chemokine ligand 2 Homo sapiens 100-104 30242884-9 2018 A particular role in melatonin"s actions seems to be associated with the upregulation of sirtuin-1 (SIRT1), which shares various effects known from melatonin and additionally interferes with the signaling by the mechanistic target of rapamycin (mTOR) and Notch, and reduces the expression of the proinflammatory lncRNA-CCL2. Melatonin 21-30 C-C motif chemokine ligand 2 Homo sapiens 319-323 29957728-8 2018 Intramuscular MCP-1 was increased at 1H, 5H, and 48H in all groups. Hydrogen 37-39 C-C motif chemokine ligand 2 Homo sapiens 14-19 29957728-8 2018 Intramuscular MCP-1 was increased at 1H, 5H, and 48H in all groups. 48H 49-52 C-C motif chemokine ligand 2 Homo sapiens 14-19 30392338-0 2018 [Aspirin inhibits cell stemness of esophageal cancer by downregulation of chemokine CCL2]. Aspirin 1-8 C-C motif chemokine ligand 2 Homo sapiens 84-88 30392338-8 2018 When chemokine CCL2 was knocked down, the levels of Nanog gene in M2+ shCCL2-KYSE450+ ASA group and M2+ shCCL2-KYSE450 group were decreased to 1.22+-0.11 and 1.17+-0.08, respectively, and there was no statistically significant difference between them (P=0.69). Aspirin 86-89 C-C motif chemokine ligand 2 Homo sapiens 15-19 30392338-11 2018 Conclusions: Tumor-associated macrophages enhances the stemness of esophageal cancer cells, whereas aspirin attenuates the stemness by suppressing the expression of CCL2. Aspirin 100-107 C-C motif chemokine ligand 2 Homo sapiens 165-169 30201767-0 2018 Hypothalamic CCL2/CCR2 Chemokine System: Role in Sexually Dimorphic Effects of Maternal Ethanol Exposure on Melanin-Concentrating Hormone and Behavior in Adolescent Offspring. Ethanol 88-95 C-C motif chemokine ligand 2 Homo sapiens 13-17 30201767-4 2018 We demonstrate that maternal administration of ethanol (2 g/kg/d) from embryonic day 10 (E10) to E15, while having little impact on glia, stimulates expression of neuronal CCL2 and CCR2, increases density of both large CCL2 neurons colocalizing MCH and small CCL2 neurons surrounding MCH neurons, and stimulates ethanol drinking and anxiety in adolescent offspring. Ethanol 47-54 C-C motif chemokine ligand 2 Homo sapiens 172-176 30402038-7 2018 Lonafarnib significantly suppressed LPS-, IL-1beta-, or TNF-alpha-induced IL-6, IL-8, MCP-1, and GRO-alpha expression and secretion in placental tissue. lonafarnib 0-10 C-C motif chemokine ligand 2 Homo sapiens 86-91 30201767-4 2018 We demonstrate that maternal administration of ethanol (2 g/kg/d) from embryonic day 10 (E10) to E15, while having little impact on glia, stimulates expression of neuronal CCL2 and CCR2, increases density of both large CCL2 neurons colocalizing MCH and small CCL2 neurons surrounding MCH neurons, and stimulates ethanol drinking and anxiety in adolescent offspring. Ethanol 47-54 C-C motif chemokine ligand 2 Homo sapiens 219-223 30201767-4 2018 We demonstrate that maternal administration of ethanol (2 g/kg/d) from embryonic day 10 (E10) to E15, while having little impact on glia, stimulates expression of neuronal CCL2 and CCR2, increases density of both large CCL2 neurons colocalizing MCH and small CCL2 neurons surrounding MCH neurons, and stimulates ethanol drinking and anxiety in adolescent offspring. Ethanol 47-54 C-C motif chemokine ligand 2 Homo sapiens 219-223 30201767-5 2018 We show that these neuronal and behavioral changes are similarly produced by maternal administration of CCL2 (4 or 8 mug/kg/d, E10-E15) and blocked by maternal administration of a CCR2 antagonist INCB3344 (1 mg/kg/d, E10-E15), and these effects of ethanol and CCL2 are sexually dimorphic, consistently stronger in females. Ethanol 248-255 C-C motif chemokine ligand 2 Homo sapiens 104-108 30201767-6 2018 These results suggest that this neuronal CCL2/CCR2 system closely linked to MCH neurons has a role in mediating the effects of maternal ethanol exposure on adolescent offspring and contributes to the higher levels of adolescent risk factors for alcohol use disorders described in women.SIGNIFICANCE STATEMENT Ethanol consumption and inflammatory agents during pregnancy similarly increase alcohol intake and anxiety in adolescent offspring. Ethanol 136-143 C-C motif chemokine ligand 2 Homo sapiens 41-45 30201767-6 2018 These results suggest that this neuronal CCL2/CCR2 system closely linked to MCH neurons has a role in mediating the effects of maternal ethanol exposure on adolescent offspring and contributes to the higher levels of adolescent risk factors for alcohol use disorders described in women.SIGNIFICANCE STATEMENT Ethanol consumption and inflammatory agents during pregnancy similarly increase alcohol intake and anxiety in adolescent offspring. Alcohols 245-252 C-C motif chemokine ligand 2 Homo sapiens 41-45 30201767-6 2018 These results suggest that this neuronal CCL2/CCR2 system closely linked to MCH neurons has a role in mediating the effects of maternal ethanol exposure on adolescent offspring and contributes to the higher levels of adolescent risk factors for alcohol use disorders described in women.SIGNIFICANCE STATEMENT Ethanol consumption and inflammatory agents during pregnancy similarly increase alcohol intake and anxiety in adolescent offspring. Ethanol 309-316 C-C motif chemokine ligand 2 Homo sapiens 41-45 30201767-6 2018 These results suggest that this neuronal CCL2/CCR2 system closely linked to MCH neurons has a role in mediating the effects of maternal ethanol exposure on adolescent offspring and contributes to the higher levels of adolescent risk factors for alcohol use disorders described in women.SIGNIFICANCE STATEMENT Ethanol consumption and inflammatory agents during pregnancy similarly increase alcohol intake and anxiety in adolescent offspring. Alcohols 389-396 C-C motif chemokine ligand 2 Homo sapiens 41-45 30201767-8 2018 We demonstrate in adolescent offspring that maternal administration of CCL2, like ethanol, stimulates these neurons and increases ethanol drinking and anxiety, and these effects of ethanol are blocked by maternal CCR2 antagonist and consistently stronger in females. Ethanol 82-89 C-C motif chemokine ligand 2 Homo sapiens 71-75 30201767-8 2018 We demonstrate in adolescent offspring that maternal administration of CCL2, like ethanol, stimulates these neurons and increases ethanol drinking and anxiety, and these effects of ethanol are blocked by maternal CCR2 antagonist and consistently stronger in females. Ethanol 130-137 C-C motif chemokine ligand 2 Homo sapiens 71-75 30201767-8 2018 We demonstrate in adolescent offspring that maternal administration of CCL2, like ethanol, stimulates these neurons and increases ethanol drinking and anxiety, and these effects of ethanol are blocked by maternal CCR2 antagonist and consistently stronger in females. Ethanol 130-137 C-C motif chemokine ligand 2 Homo sapiens 71-75 29407194-4 2018 A selective alpha1-ADR agonist, phenylephrine, increased intracellular Ca2+-levels in cultured HTPCs and induced COX-2, IL-6 and MCP-1 mRNA expression without affecting IL-1beta mRNA. Phenylephrine 32-45 C-C motif chemokine ligand 2 Homo sapiens 129-134 30886977-8 2018 Results: Resveratrol reduced monocyte chemoattractant protein 1 production by synovial fluid mononuclear cells significantly (p = 0.005) compared to untreated controls. Resveratrol 9-20 C-C motif chemokine ligand 2 Homo sapiens 29-63 30886977-10 2018 Further, the combination of methotrexate and resveratrol significantly reduced monocyte chemoattractant protein 1 levels compared with methotrexate alone in cultures from patients with low disease activity (p = 0.016), and in cultures with high lymphocyte count (p = 0.011). Methotrexate 28-40 C-C motif chemokine ligand 2 Homo sapiens 79-113 30886977-10 2018 Further, the combination of methotrexate and resveratrol significantly reduced monocyte chemoattractant protein 1 levels compared with methotrexate alone in cultures from patients with low disease activity (p = 0.016), and in cultures with high lymphocyte count (p = 0.011). Resveratrol 45-56 C-C motif chemokine ligand 2 Homo sapiens 79-113 29990859-0 2018 Alkyl-glycerophosphate-mediated C-C motif chemokine 2 secretion induces oxidative stress via increased PPARgamma activation in human umbilical vein endothelial cells. alkyl-glycerophosphate 0-22 C-C motif chemokine ligand 2 Homo sapiens 32-53 29983334-5 2018 Here, we show that primary human monocytes stimulated with Shiga toxin 1a (Stx1a) through the glycolipid receptor globotriaosylceramide released larger amounts of proinflammatory molecules (IL-1beta, TNFalpha, IL-6, G-CSF, CXCL8, CCL2, CCL4) than Stx1a-treated neutrophils. globotriaosylceramide 114-135 C-C motif chemokine ligand 2 Homo sapiens 230-234 30099007-4 2018 The pan-specific AR agonist, 5"-N-Ethylcarboxamidoadenosine (NECA) inhibited C3a-induced LAD2 cell migration, adhesion, degranulation, production of CCL2, and ERK1/2 phosphorylation. Adenosine-5'-(N-ethylcarboxamide) 29-59 C-C motif chemokine ligand 2 Homo sapiens 149-153 30099007-4 2018 The pan-specific AR agonist, 5"-N-Ethylcarboxamidoadenosine (NECA) inhibited C3a-induced LAD2 cell migration, adhesion, degranulation, production of CCL2, and ERK1/2 phosphorylation. Adenosine-5'-(N-ethylcarboxamide) 61-65 C-C motif chemokine ligand 2 Homo sapiens 149-153 29803697-4 2018 Cyanidin also attenuated endotoxin induced myocardial injury by modulating inflammatory cytokines (Tumor necrosis factor alpha or TNFalpha, Interleukin-1 beta or IL-1beta, macrophage inflammatory protein 2 or MIP-2 and chemokine (C-C motif) ligand 2 also known as monocyte chemoattractant protein 1 or MCP1) and oxidative stress (protein nitration). cyanidin 0-8 C-C motif chemokine ligand 2 Homo sapiens 219-249 29803697-4 2018 Cyanidin also attenuated endotoxin induced myocardial injury by modulating inflammatory cytokines (Tumor necrosis factor alpha or TNFalpha, Interleukin-1 beta or IL-1beta, macrophage inflammatory protein 2 or MIP-2 and chemokine (C-C motif) ligand 2 also known as monocyte chemoattractant protein 1 or MCP1) and oxidative stress (protein nitration). cyanidin 0-8 C-C motif chemokine ligand 2 Homo sapiens 264-298 29803697-4 2018 Cyanidin also attenuated endotoxin induced myocardial injury by modulating inflammatory cytokines (Tumor necrosis factor alpha or TNFalpha, Interleukin-1 beta or IL-1beta, macrophage inflammatory protein 2 or MIP-2 and chemokine (C-C motif) ligand 2 also known as monocyte chemoattractant protein 1 or MCP1) and oxidative stress (protein nitration). cyanidin 0-8 C-C motif chemokine ligand 2 Homo sapiens 302-306 29959625-7 2018 Spilanthol decreased the expression of PGE2, COX-2, TNF-alpha, and MCP-1. N-isobutyl-2E-decenamide 0-10 C-C motif chemokine ligand 2 Homo sapiens 67-72 30102465-10 2018 PA enhances the expression of MCP-1, IL-6, and COX-2 genes, while POA downregulates these genes, decreases expression of NFkappaB, and upregulates PPAR-alpha gene expression. Palmitic Acid 0-2 C-C motif chemokine ligand 2 Homo sapiens 30-35 30039507-6 2018 This way we were able to show that the decrease of cerebral ACh triggers increased secretion of IL-1beta, IL-6, TNFalpha, MIP-2 (CCL3), RANTES, MCP1, IFNgamma, and IP-10. Acetylcholine 60-63 C-C motif chemokine ligand 2 Homo sapiens 144-148 30100024-14 2018 RESULTS: Simvastatin reduced TLR4-induced ICAM-1, IL-8, and MCP-1 expression in AVICs. Simvastatin 9-20 C-C motif chemokine ligand 2 Homo sapiens 60-65 28852897-1 2018 PURPOSE: In this study, we elucidated the effects of berberine, a major alkaloid component contained in medicinal herbs, such as Phellodendri Cortex and Coptidis Rhizoma, on expression of monocyte chemotactic protein-1 (MCP-1) and interleukin-8 (IL-8) in a human retinal pigment epithelial cell line (ARPE-19) caused by lipopolysaccharide (LPS) stimulation. Berberine 53-62 C-C motif chemokine ligand 2 Homo sapiens 188-218 28852897-1 2018 PURPOSE: In this study, we elucidated the effects of berberine, a major alkaloid component contained in medicinal herbs, such as Phellodendri Cortex and Coptidis Rhizoma, on expression of monocyte chemotactic protein-1 (MCP-1) and interleukin-8 (IL-8) in a human retinal pigment epithelial cell line (ARPE-19) caused by lipopolysaccharide (LPS) stimulation. Berberine 53-62 C-C motif chemokine ligand 2 Homo sapiens 220-225 28852897-7 2018 CONCLUSIONS: These findings indicate that berberine inhibited the expression of MCP-1 and IL-8 induced by LPS. Berberine 42-51 C-C motif chemokine ligand 2 Homo sapiens 80-85 30079432-10 2018 Participants having higher levels of plasma MCP-1 reported higher SOWS, most notably after the buprenorphine taper ended. Buprenorphine 95-108 C-C motif chemokine ligand 2 Homo sapiens 44-49 30217257-8 2018 RESULTS: Honokiol significantly decreased pro-inflammatory cytokine (IL1A, IL6) and chemokine (CXCL8, CXCL1, CCL2) mRNA expression and secretion from fetal membranes (amnion and choriodecidua) and myometrium stimulated with LPS, fsl-1 or poly(I:C). honokiol 9-17 C-C motif chemokine ligand 2 Homo sapiens 109-113 30266096-8 2018 RESULTS: Ingenol mebutat significantly and dose-dependently induced the expression of proinflammatory chemokines (CXCL8, CCL2) and AMP (RNase7, HBD3) in HEK and epithelial cancer cell lines. ingenol 9-16 C-C motif chemokine ligand 2 Homo sapiens 121-125 30002156-4 2018 Mechanistically, we show that circulating T-MPs readily enter the lung parenchyma where they are taken up by local macrophages and induce CCL2 production. t-mps 42-47 C-C motif chemokine ligand 2 Homo sapiens 138-142 30141614-0 2018 C-C Chemokine Ligand 2 (CCL2) Recruits Macrophage-Membrane-Camouflaged Hollow Bismuth Selenide Nanoparticles To Facilitate Photothermal Sensitivity and Inhibit Lung Metastasis of Breast Cancer. bismuth selenide 78-94 C-C motif chemokine ligand 2 Homo sapiens 0-22 30141614-0 2018 C-C Chemokine Ligand 2 (CCL2) Recruits Macrophage-Membrane-Camouflaged Hollow Bismuth Selenide Nanoparticles To Facilitate Photothermal Sensitivity and Inhibit Lung Metastasis of Breast Cancer. bismuth selenide 78-94 C-C motif chemokine ligand 2 Homo sapiens 24-28 30254419-3 2018 Results: PMACI results in a significant increase in the production of proinflammatory cytokines, such as TNF-alpha, IL-1beta, MCP-1, IL-6 and as well as histamine. pmaci 9-14 C-C motif chemokine ligand 2 Homo sapiens 126-131 29864522-6 2018 CCL2 increased the phosphorylation levels of PKCalpha (Thr638), P38MAPK (Thr180/Tyr182) and HSP27 (S78/S82) in human platelets, which were abrogated by PKCalpha inhibitor (RO 318220) or P38MAPK inhibitor (SB 203580). Ro 31-8220 172-181 C-C motif chemokine ligand 2 Homo sapiens 0-4 29864522-6 2018 CCL2 increased the phosphorylation levels of PKCalpha (Thr638), P38MAPK (Thr180/Tyr182) and HSP27 (S78/S82) in human platelets, which were abrogated by PKCalpha inhibitor (RO 318220) or P38MAPK inhibitor (SB 203580). SB 203580 205-214 C-C motif chemokine ligand 2 Homo sapiens 0-4 29864522-7 2018 RO 318220 or SB 203580 diminished CCL2-induced platelet function. Antimony 13-15 C-C motif chemokine ligand 2 Homo sapiens 34-38 30237731-6 2018 After stimulation with LPS, we observed an exacerbated increase in TNF-alpha, IL-6, and MCP-1 concentration in the high glucose condition compared to the normal glucose environment. Glucose 120-127 C-C motif chemokine ligand 2 Homo sapiens 88-93 30129532-7 2018 In vitro, eosin treatment significantly decreased the release of CCL2, CCL5, and VEGF-A by keratinocytes and angiopoietin-2 by endothelial cells. Eosine Yellowish-(YS) 10-15 C-C motif chemokine ligand 2 Homo sapiens 65-69 30230985-8 2018 Serum MCP-1 levels in systemic vasculitis patients were positively correlated with serum creatinine levels (r = 0.387, P < 0.010) and with 24-h proteinuria (r = 0.404, P < 0.014). Creatinine 89-99 C-C motif chemokine ligand 2 Homo sapiens 6-11 29777873-5 2018 In addition, cinnamaldehyde reduced monocyte chemotactic protein-1 (MCP-1), matrix metalloproteinase-2 (MMP-2) and lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) expression. cinnamaldehyde 13-27 C-C motif chemokine ligand 2 Homo sapiens 36-66 29777873-5 2018 In addition, cinnamaldehyde reduced monocyte chemotactic protein-1 (MCP-1), matrix metalloproteinase-2 (MMP-2) and lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) expression. cinnamaldehyde 13-27 C-C motif chemokine ligand 2 Homo sapiens 68-73 30015902-5 2018 Pretreatment with spilanthol decreased TNF-alpha-induced COX-2 expression by western blotting and suppressed the expression of pro-inflammatory mediators, including interleukin (IL)-6, IL-8 and monocyte chemotactic protein 1 using ELISA. N-isobutyl-2E-decenamide 18-28 C-C motif chemokine ligand 2 Homo sapiens 194-224 29792849-7 2018 The expression and secretion of MCP-1 induced by PA was also similarly prevented by TRAM-34 and KCa3.1 siRNA. Palmitic Acid 49-51 C-C motif chemokine ligand 2 Homo sapiens 32-37 29792849-8 2018 These results demonstrate for the first time that PA upregulates KCa3.1 channels through TLR2/4, p38-MAPK and NF-kappaB pathway to promote the expression of MCP-1, and then induce the trans-endothelial migration of monocytes. Palmitic Acid 50-52 C-C motif chemokine ligand 2 Homo sapiens 157-162 30010336-2 2018 The unusually large quadrupole splitting (Delta EQ = +2.2 mm s-1) and asymmetric parameter (eta = 0.9) of the five-coordinate heme carbene [Fe(TTP)(CCl2)], which is the largest among all known low spin ferrohemes, has driven investigations by means of Mossbauer effect Nuclear Resonance Vibrational Spectroscopy (NRVS). heme carbene 126-138 C-C motif chemokine ligand 2 Homo sapiens 148-152 30010336-2 2018 The unusually large quadrupole splitting (Delta EQ = +2.2 mm s-1) and asymmetric parameter (eta = 0.9) of the five-coordinate heme carbene [Fe(TTP)(CCl2)], which is the largest among all known low spin ferrohemes, has driven investigations by means of Mossbauer effect Nuclear Resonance Vibrational Spectroscopy (NRVS). Iron 140-142 C-C motif chemokine ligand 2 Homo sapiens 148-152 30010336-2 2018 The unusually large quadrupole splitting (Delta EQ = +2.2 mm s-1) and asymmetric parameter (eta = 0.9) of the five-coordinate heme carbene [Fe(TTP)(CCl2)], which is the largest among all known low spin ferrohemes, has driven investigations by means of Mossbauer effect Nuclear Resonance Vibrational Spectroscopy (NRVS). ferrohemes 202-212 C-C motif chemokine ligand 2 Homo sapiens 148-152 29372505-9 2018 After cocaine challenge, sCD40 ligand levels decreased in subjects and were significantly lower at 24 h. MCP-1 levels decreased and were significantly lower at the 6-day time point. Cocaine 6-13 C-C motif chemokine ligand 2 Homo sapiens 105-110 30228938-8 2018 Our study suggests that targeting the CCL2/CCR2 chemokine axis decreases TAM at the metastatic site, disrupting the immunosuppressive TME and rendering mCRC susceptible to anti-tumor T-cell responses. tam 73-76 C-C motif chemokine ligand 2 Homo sapiens 38-42 29573529-5 2018 Dapagliflozin decreased urinary KIM-1 excretion by 22.6% (0.3%-39.8%; P = .05) and IL-6 excretion by 23.5% (1.4%-40.6%; P = .04) compared to placebo, whereas no changes in NGAL, LFABP and MCP-1 were observed. dapagliflozin 0-13 C-C motif chemokine ligand 2 Homo sapiens 188-193 30078983-9 2018 Results: The CE-CKC emulsions decreased inflammatory gene expression in LPS-stimulated PBMCs (IFN-gamma, IL-17A, CXCL-9, and TNFalpha) and LPS-stimulated HCE-2 cells (THBS1 and CCL2). CKC 16-19 C-C motif chemokine ligand 2 Homo sapiens 177-181 29758489-4 2018 Fisetin significantly inhibited COX-2 expression and reduced prostaglandin E2 production, and it suppressed the levels of IL-8, CCL5, monocyte chemotactic protein 1, tumor necrosis factor alpha, and IL-6. fisetin 0-7 C-C motif chemokine ligand 2 Homo sapiens 134-164 30116631-9 2018 Results: MG132 decreased the secretion of MCP-1 in the culture medium of RPE, but it increased the expression of IL-6 mRNA in RPE and IL-6 protein level in the culture medium of RPE. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 9-14 C-C motif chemokine ligand 2 Homo sapiens 42-47 29976873-6 2018 Tianeptine attenuated microglia activation by decreasing the expression of cluster of differentiation 40 (CD40), and major histocompatibility complex class II (MHC II) markers, as well as the release of pro-inflammatory factors: interleukin (IL)-1beta, IL-18, IL-6, tumor necrosis factor alpha (TNF-alpha), and chemokine CC motif ligand 2 (CCL2), and the production of nitric oxide and reactive oxygen species. tianeptine 0-10 C-C motif chemokine ligand 2 Homo sapiens 311-338 29976873-6 2018 Tianeptine attenuated microglia activation by decreasing the expression of cluster of differentiation 40 (CD40), and major histocompatibility complex class II (MHC II) markers, as well as the release of pro-inflammatory factors: interleukin (IL)-1beta, IL-18, IL-6, tumor necrosis factor alpha (TNF-alpha), and chemokine CC motif ligand 2 (CCL2), and the production of nitric oxide and reactive oxygen species. tianeptine 0-10 C-C motif chemokine ligand 2 Homo sapiens 340-344 30116142-5 2018 Folic acid and choline decreased C-C motif chemokine ligand 2 (CCL2) mRNA levels. Folic Acid 0-10 C-C motif chemokine ligand 2 Homo sapiens 33-61 30116142-5 2018 Folic acid and choline decreased C-C motif chemokine ligand 2 (CCL2) mRNA levels. Folic Acid 0-10 C-C motif chemokine ligand 2 Homo sapiens 63-67 30116142-5 2018 Folic acid and choline decreased C-C motif chemokine ligand 2 (CCL2) mRNA levels. Choline 15-22 C-C motif chemokine ligand 2 Homo sapiens 33-61 30116142-5 2018 Folic acid and choline decreased C-C motif chemokine ligand 2 (CCL2) mRNA levels. Choline 15-22 C-C motif chemokine ligand 2 Homo sapiens 63-67 30006619-7 2018 S1P3 mediates its effects on BTB permeability through astrocytic secretion of IL-6 and CCL2, which relaxes endothelial cell adhesion. btb 29-32 C-C motif chemokine ligand 2 Homo sapiens 87-91 29626298-6 2018 G6PD/GSH deficiency induced by either siRNA or inhibitors (6AN/BSO, respectively) significantly (p < 0.005) increased the levels of cell adhesion molecules (ICAM-1, VCAM-1, SELL, ITGB1 and 2); NADPH oxidase (NOX), reactive oxygen species (ROS) and MCP-1 were upregulated, and decreases in levels of GSH, and nitric oxide were observed. Glutathione 5-8 C-C motif chemokine ligand 2 Homo sapiens 251-256 29678503-6 2018 Cytokine levels of IL-8, MIP-1beta, IL-6, IFN-gamma, GM-CSF, TNF, IL-2, IL-4, MCP-1, and IL-10 were decreased significantly with caffeine treatment. Caffeine 129-137 C-C motif chemokine ligand 2 Homo sapiens 78-83 30061946-11 2018 These results demonstrated that chemoresistance may be mediated by cell stress responses involving CCL2 expression, suggesting that CCL2 may be a potential target for enhancing the therapeutic effect of DTX in lung cancer. Docetaxel 203-206 C-C motif chemokine ligand 2 Homo sapiens 99-103 29794037-6 2018 Palmitate, but not palmitoleate, had mild effects on Akt phosphorylation but significantly inhibited insulin-stimulated GLUT4 translocation and increased expression of pro-inflammatory cytokines Il6 and Ccl2 Ceramides, hexosylceramides, and sphingosine-1-phosphate significantly heightened by palmitate correlated negatively with insulin sensitivity and positively with pro-inflammatory indices. Palmitates 0-9 C-C motif chemokine ligand 2 Homo sapiens 203-207 29794037-6 2018 Palmitate, but not palmitoleate, had mild effects on Akt phosphorylation but significantly inhibited insulin-stimulated GLUT4 translocation and increased expression of pro-inflammatory cytokines Il6 and Ccl2 Ceramides, hexosylceramides, and sphingosine-1-phosphate significantly heightened by palmitate correlated negatively with insulin sensitivity and positively with pro-inflammatory indices. Ceramides 208-217 C-C motif chemokine ligand 2 Homo sapiens 203-207 30061946-0 2018 CCL2 influences the sensitivity of lung cancer A549 cells to docetaxel. Docetaxel 61-70 C-C motif chemokine ligand 2 Homo sapiens 0-4 30061946-6 2018 Reverse transcription-quantitative polymerase chain reaction and western blot analysis revealed that DTX treatment increased the mRNA and protein expression of CCL2 in lung cancer A549 cells. Docetaxel 101-104 C-C motif chemokine ligand 2 Homo sapiens 160-164 30061946-8 2018 An MTT assay indicated that CCL2 downregulation decreased the viability of A549 cells and augmented the DTX-induced cytotoxicity, whereas CCL2 upregulation protected A549 cells from DTX-induced cytotoxicity. monooxyethylene trimethylolpropane tristearate 3-6 C-C motif chemokine ligand 2 Homo sapiens 28-32 30061946-8 2018 An MTT assay indicated that CCL2 downregulation decreased the viability of A549 cells and augmented the DTX-induced cytotoxicity, whereas CCL2 upregulation protected A549 cells from DTX-induced cytotoxicity. Docetaxel 104-107 C-C motif chemokine ligand 2 Homo sapiens 28-32 30061946-8 2018 An MTT assay indicated that CCL2 downregulation decreased the viability of A549 cells and augmented the DTX-induced cytotoxicity, whereas CCL2 upregulation protected A549 cells from DTX-induced cytotoxicity. Docetaxel 182-185 C-C motif chemokine ligand 2 Homo sapiens 138-142 30061946-9 2018 Additionally, it was revealed that CCL2 overexpression activated phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling and inhibited apoptosis-associated protein caspase-3 activation and B-cell lymphoma 2 (Bcl-2) phosphorylation at Ser70 induced by DTX, and enhanced DTX-induced Bcl-2-associated death promoter phosphorylation at Ser112. Docetaxel 261-264 C-C motif chemokine ligand 2 Homo sapiens 35-39 30061946-9 2018 Additionally, it was revealed that CCL2 overexpression activated phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling and inhibited apoptosis-associated protein caspase-3 activation and B-cell lymphoma 2 (Bcl-2) phosphorylation at Ser70 induced by DTX, and enhanced DTX-induced Bcl-2-associated death promoter phosphorylation at Ser112. Docetaxel 279-282 C-C motif chemokine ligand 2 Homo sapiens 35-39 29645296-8 2018 Moreover, Ruxolitinib reduced MSC secretion of MCP-1 and IL-6. ruxolitinib 10-21 C-C motif chemokine ligand 2 Homo sapiens 47-52 29928429-12 2018 However, of 28 distinct soluble immune-modulating molecules (i.e. chemokines, cytokines and soluble co-stimulators) only C-C motif chemokine ligand 2 (CCL2), CCL24 and sCD27 were affected by bortezomib-based therapy. Bortezomib 191-201 C-C motif chemokine ligand 2 Homo sapiens 121-149 29554018-0 2018 Chemokine CCL2 and its receptor CCR2 in the dorsal root ganglion contribute to oxaliplatin-induced mechanical hypersensitivity. Oxaliplatin 79-90 C-C motif chemokine ligand 2 Homo sapiens 10-14 29554018-5 2018 Immunohistochemical showed that the expression of CCL2/CCR2 started to increase by 4 hours after oxaliplatin treatment, was significantly increased at day 4, and then both signals became normalized by day 15. Oxaliplatin 97-108 C-C motif chemokine ligand 2 Homo sapiens 50-54 29554018-6 2018 Cotreatment with intrathecal anti-CCL2 antibodies prevented the development of oxaliplatin-induced mechanical hyperresponsiveness, and transiently reversed established hyperalgesia when given 1 week after chemotherapy. Oxaliplatin 79-90 C-C motif chemokine ligand 2 Homo sapiens 34-38 29554018-7 2018 This is the first study to demonstrate CCL2/CCR2 signaling in a model of oxaliplatin-related CIPN; and it further shows that blocking of this signal can attenuate the development of oxaliplatin-induced mechanical hyperalgesia. Oxaliplatin 73-84 C-C motif chemokine ligand 2 Homo sapiens 39-43 29554018-7 2018 This is the first study to demonstrate CCL2/CCR2 signaling in a model of oxaliplatin-related CIPN; and it further shows that blocking of this signal can attenuate the development of oxaliplatin-induced mechanical hyperalgesia. Oxaliplatin 182-193 C-C motif chemokine ligand 2 Homo sapiens 39-43 30061946-10 2018 PI3K/AKT inhibitor LY294002 restored DTX-induced caspase-3 activation and Bcl-2 phosphorylation, reversed the effect of CCL2 on the viability of A549 cells and enhanced DTX-induced cytotoxicity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 19-27 C-C motif chemokine ligand 2 Homo sapiens 120-124 30061946-11 2018 These results demonstrated that chemoresistance may be mediated by cell stress responses involving CCL2 expression, suggesting that CCL2 may be a potential target for enhancing the therapeutic effect of DTX in lung cancer. Docetaxel 203-206 C-C motif chemokine ligand 2 Homo sapiens 132-136 29934505-3 2018 Here we examined the levels of CCL2 in 4 breast cancer cell lines along with 57 human breast cancer specimens and found them significantly increased with presence of 17beta-estradiol (E2) in estrogen receptor (ER)-positive breast cancer cells, while anti-estrogen treatment weakened this enhancement. Estradiol 166-182 C-C motif chemokine ligand 2 Homo sapiens 31-35 29933753-15 2018 At 72 h, we found elevated plasma levels of IL-5, MCP-1, and IL-17 in NAIS. nais 70-74 C-C motif chemokine ligand 2 Homo sapiens 50-55 29730267-2 2018 Here, we showed that Imatinib significantly prevented macrophage M2-like polarization induced by IL-13 or IL-4 in vitro, as illustrated by reduced expression of cell surface marker CD206 and M2-like genes, including Arg1, Mgl2, Mrc1, CDH1, and CCL2. Imatinib Mesylate 21-29 C-C motif chemokine ligand 2 Homo sapiens 244-248 29596892-13 2018 In conclusion, the cholesterol sensor SCAP plays a role in regulating the expression of inflammatory factors such as IL-1beta, TNF-alpha, and MCP-1 in THP-1 macrophages. Cholesterol 19-30 C-C motif chemokine ligand 2 Homo sapiens 142-147 29914535-5 2018 RESULTS: After the bone cut and surgery, TXA significantly increased MCP-1, TNF-alpha, IL-1beta and IL-6 levels compared to non-TXA patients, which was further amplified postoperatively. Tranexamic Acid 41-44 C-C motif chemokine ligand 2 Homo sapiens 69-74 29234825-2 2018 Bindarit, a CCL2 inhibitor, is a small anti-inflammatory molecule proven safe by phase II trials in type 2 diabetic nephropathy patients. bindarit 0-8 C-C motif chemokine ligand 2 Homo sapiens 12-16 29874809-6 2018 The anti-inflammatory properties of tHGA were assessed by monocyte adhesion assay and analysis of MCP-1 and ICAM-1 expression. 2,4,6-trihydroxy-3-geranylacetophenone 36-40 C-C motif chemokine ligand 2 Homo sapiens 98-103 29874809-10 2018 tHGA suppressed leukocyte adhesion to TNF-alpha-induced epithelium and reduced MCP-1 and ICAM-1 gene expression and secretion. 2,4,6-trihydroxy-3-geranylacetophenone 0-4 C-C motif chemokine ligand 2 Homo sapiens 79-84 29410350-6 2018 Osmotin suppressed lipopolysaccharide-induced upregulation of tumor necrosis factor-alpha (TNF-alpha), monocyte chemotactic protein-1, vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and E-selectin in HUVECs, and TNF-alpha-induced THP-1-HUVEC adhesion. osmotin 0-7 C-C motif chemokine ligand 2 Homo sapiens 103-133 29659888-12 2018 Intramyocellular lipids (P = 0.04), monocyte chemoattractant protein-1 (P = 0.04), and high-density lipoprotein (P = 0.04) improved among those randomized to eplerenone vs placebo. Eplerenone 158-168 C-C motif chemokine ligand 2 Homo sapiens 36-70 29704322-8 2018 In addition, quantitative real-time polymerase chain reaction showed that after implantation of EGCG-modified collagen membranes, expression of CXCL1 (predominant chemoattractants to neutrophils and inflammation promotors) was significantly downregulated, whereas expressions of STAB1, CCR2, CCR3, CCL2, and CCL3 (related to M2 macrophages) were significantly upregulated. epigallocatechin gallate 96-100 C-C motif chemokine ligand 2 Homo sapiens 298-302 29632147-0 2018 The Synergy between Palmitate and TNF-alpha for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation. Palmitates 20-29 C-C motif chemokine ligand 2 Homo sapiens 48-52 29538260-12 2018 Endothelial cell treatment with NIM811 during the early postreperfusion period rescued mitochondrial fitness and reduced EC immunogenicity by decreasing CCL2, KC release, and VCAM-1, MHC-I, TAP1 expression. (melle-4)cyclosporin 32-38 C-C motif chemokine ligand 2 Homo sapiens 153-157 29785210-9 2018 Resistin/RBP4, visfatin/MCP-1 and MCP-1/RBP4 ratios were strongly correlated with the levels of fasting glucose, HbA1c and HOMA-beta. Glucose 104-111 C-C motif chemokine ligand 2 Homo sapiens 34-39 29726680-0 2018 Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner. stilbenoids 8-19 C-C motif chemokine ligand 2 Homo sapiens 134-138 29772762-9 2018 In humans, chloroquine treatment did not affect viremia or clinical parameters during the acute stage of the disease (D1 to D14), but affected the levels of C-reactive Protein (CRP), IFNalpha, IL-6, and MCP1 over time (D1 to D16). Chloroquine 11-22 C-C motif chemokine ligand 2 Homo sapiens 203-207 29632147-4 2018 Our data show that treatment of THP-1 and primary human monocytic cells with palmitate and TNF-alpha led to a marked increase in CCL2 production compared with either treatment alone. Palmitates 77-86 C-C motif chemokine ligand 2 Homo sapiens 129-133 29632147-7 2018 Moreover, IRF3 activation by polyinosinic-polycytidylic acid augmented TNF-alpha-induced CCL2 secretion. Poly I-C 29-60 C-C motif chemokine ligand 2 Homo sapiens 89-93 29668284-8 2018 HCQ pretreatment caused a significant decrease of TNF-alpha and MCP-1 secretion and an increase of IL-1beta and CXCL10 release from UC-MSCs. Hydroxychloroquine 0-3 C-C motif chemokine ligand 2 Homo sapiens 64-69 28835131-7 2018 DHA slightly countered the actions of IL-1beta on CCL2, IL6 and ADIPOQ expression, though not on secretion of these adipokines. Docosahexaenoic Acids 0-3 C-C motif chemokine ligand 2 Homo sapiens 50-54 29496661-5 2018 The second wave of Ly6CHi cells in diabetic wounds corresponded to a spike in MCP-1 (monocyte chemoattractant protein-1) and selective administration of anti-MCP-1 reversed the second Ly6CHi influx and improved wound healing. ly6chi 19-25 C-C motif chemokine ligand 2 Homo sapiens 85-119 29496661-5 2018 The second wave of Ly6CHi cells in diabetic wounds corresponded to a spike in MCP-1 (monocyte chemoattractant protein-1) and selective administration of anti-MCP-1 reversed the second Ly6CHi influx and improved wound healing. ly6chi 19-25 C-C motif chemokine ligand 2 Homo sapiens 158-163 29477409-1 2018 The chemokine CC motif ligand 2 (CCL2) is important in recruiting tumor-associated macrophages and is involved in the development of castration-resistance prostate cancer (CRPC) after androgen-deprivation therapy (ADT); however, the underlying mechanism remains unclear. adt 214-217 C-C motif chemokine ligand 2 Homo sapiens 4-31 29496661-5 2018 The second wave of Ly6CHi cells in diabetic wounds corresponded to a spike in MCP-1 (monocyte chemoattractant protein-1) and selective administration of anti-MCP-1 reversed the second Ly6CHi influx and improved wound healing. ly6chi 19-25 C-C motif chemokine ligand 2 Homo sapiens 78-83 29477409-1 2018 The chemokine CC motif ligand 2 (CCL2) is important in recruiting tumor-associated macrophages and is involved in the development of castration-resistance prostate cancer (CRPC) after androgen-deprivation therapy (ADT); however, the underlying mechanism remains unclear. adt 214-217 C-C motif chemokine ligand 2 Homo sapiens 33-37 29477409-6 2018 In tissues from prostate cancer patients with ADT, low SPDEF levels were correlated with high CCL2 expression compared to patients without ADT. adt 46-49 C-C motif chemokine ligand 2 Homo sapiens 94-98 29477409-7 2018 We present a novel mechanism that contributes to the EMT and metastatic phenotype observed in a subset of ADT-resistant prostate cancer, where the CCL2 is stimulated through the inactivated of AR-mediated SPDEF. adt 106-109 C-C motif chemokine ligand 2 Homo sapiens 147-151 29471285-10 2018 SAT inflammation-related gene expression (Tumor necrosis factor alpha [TNF-alpha], and monocyte chemoattractant protein-1 [MCP-1]) significantly decreased in the DHA group. Docosahexaenoic Acids 162-165 C-C motif chemokine ligand 2 Homo sapiens 87-121 29471285-10 2018 SAT inflammation-related gene expression (Tumor necrosis factor alpha [TNF-alpha], and monocyte chemoattractant protein-1 [MCP-1]) significantly decreased in the DHA group. Docosahexaenoic Acids 162-165 C-C motif chemokine ligand 2 Homo sapiens 123-128 29409972-5 2018 Moreover, HFD-induced DPP4 activity facilitated angiogenesis and cancer cell metastasis in vitro and in vivo, and vildagliptin prevented tumor progression by mediating the pro-angiogenic role of chemokine ligand 2 (CCL2). Vildagliptin 114-126 C-C motif chemokine ligand 2 Homo sapiens 215-219 29560593-1 2018 The rate constants of OH radicals with CF3CF=CCl2, CF3CH=CF2, CF3CF=CH2, CF3CH=CH2, and (CF3)2C=CH2 have been measured over the temperature range 250-430 K. Kinetic measurements have been carried out using flash photolysis and laser photolysis methods combined respectively with laser-induced fluorescence technique. oh radicals 22-33 C-C motif chemokine ligand 2 Homo sapiens 45-49 29587203-4 2018 We found that high glucose induced phosphorylation of Btk, MAPKs and NF-kappaB, and the expression of downstream inflammation cytokines monocyte chemo-attractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). Glucose 19-26 C-C motif chemokine ligand 2 Homo sapiens 136-171 29587203-4 2018 We found that high glucose induced phosphorylation of Btk, MAPKs and NF-kappaB, and the expression of downstream inflammation cytokines monocyte chemo-attractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). Glucose 19-26 C-C motif chemokine ligand 2 Homo sapiens 173-178 30398154-4 2018 LPS-treated HUVECs cultured in low magnesium showed up-regulation of mRNA expression for pro-inflammatory factors and the expression of cytokine proteins, including IL-2, IL-3, IL-8, IL-15 and MCP-1. Magnesium 35-44 C-C motif chemokine ligand 2 Homo sapiens 193-198 29854096-0 2018 Cafestol Inhibits Cyclic-Strain-Induced Interleukin-8, Intercellular Adhesion Molecule-1, and Monocyte Chemoattractant Protein-1 Production in Vascular Endothelial Cells. cafestol 0-8 C-C motif chemokine ligand 2 Homo sapiens 94-128 29854096-6 2018 Cafestol attenuated cyclic-strain-stimulated intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein- (MCP-) 1, and interleukin- (IL-) 8 secretion. cafestol 0-8 C-C motif chemokine ligand 2 Homo sapiens 89-131 29854096-9 2018 The addition of zinc protoporphyrin IX, sirtinol, or Sirt1 silencing (transfected with Sirt1 siRNA) significantly attenuated cafestol-mediated modulatory effects on cyclic-strain-stimulated ICAM-1, MCP-1, and IL-8 secretion. cafestol 125-133 C-C motif chemokine ligand 2 Homo sapiens 198-203 29436639-8 2018 Taken together, the results indicated that GL may suppress the migration of monocytes and induce apoptosis to reduce systemic inflammation by blocking downstream NF-kappaB/MCP-1 and MAPK/ERK/Mcl-1 signaling pathways. Glycyrrhizic Acid 43-45 C-C motif chemokine ligand 2 Homo sapiens 172-177 29849500-7 2018 The result showed that CBT effectively suppressed the expressions of TNF-alpha, IL-6, MCP-1, and IL-1beta in a dose-dependent manner and significantly downregulated 19 out of 32 differentially expressed genes, most of which were involved in the NOD1/NF-kappaB pathway, and also showed that CBT remarkably inhibited LPS-induced NOD1, RIP2, and NF-kappaB activation. columbianetin 23-26 C-C motif chemokine ligand 2 Homo sapiens 86-91 29249591-5 2018 RESULTS: Concentration of MCP-1 at 6 hours was higher in the serum of patients with worsened NIHSS by 24 hours (P = .009). nihss 93-98 C-C motif chemokine ligand 2 Homo sapiens 26-31 29785126-14 2018 In the whole-blood culture model, the cytokines with the most pronounced increase after OT-101 treatment were IL-1beta, IL-8, and MCP-1. ot-101 88-94 C-C motif chemokine ligand 2 Homo sapiens 130-135 29588466-5 2018 Incubation with clinically-relevant concentrations of canagliflozin, but not empagliflozin or dapagliflozin activated AMPK and inhibited IL-1beta-stimulated adhesion of pro-monocytic U937 cells and secretion of IL-6 and monocyte chemoattractant protein-1 (MCP-1). Canagliflozin 54-67 C-C motif chemokine ligand 2 Homo sapiens 220-254 29460119-9 2018 These results could shed light on understanding of the molecular basis for the inhibition of Curcumin on MCP-1 expression during the process of astrocyte activation, and provide a molecular mechanism for using Curcumin in neuropathic pain. Curcumin 93-101 C-C motif chemokine ligand 2 Homo sapiens 105-110 29460119-0 2018 Curcumin Inhibits Monocyte Chemoattractant Protein-1 Expression in TNF-alpha induced Astrocytes Through AMPK Pathway. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 18-52 29460119-6 2018 Our data demonstrated that Curcumin inhibited TNF-alpha-induced astrocytes migration, decreased MCP-1 expression, and up-regulated SOD2 expression in TNF-alpha-induced astrocytes in vitro. Curcumin 27-35 C-C motif chemokine ligand 2 Homo sapiens 96-101 29588466-5 2018 Incubation with clinically-relevant concentrations of canagliflozin, but not empagliflozin or dapagliflozin activated AMPK and inhibited IL-1beta-stimulated adhesion of pro-monocytic U937 cells and secretion of IL-6 and monocyte chemoattractant protein-1 (MCP-1). Canagliflozin 54-67 C-C motif chemokine ligand 2 Homo sapiens 256-261 29518977-4 2018 By combining statistical methods with available gene annotations and without a previously defined hypothesis HRas, MAPK14 (p38), CCL2, DOK1 and PTK2B were identified as genes possibly relevant for cisplatin resistance. Cisplatin 197-206 C-C motif chemokine ligand 2 Homo sapiens 129-133 29440506-0 2018 Carbon Monoxide Impairs CD11b+Ly-6Chi Monocyte Migration from the Blood to Inflamed Pancreas via Inhibition of the CCL2/CCR2 Axis. Carbon Monoxide 0-15 C-C motif chemokine ligand 2 Homo sapiens 115-119 29713651-5 2018 Results: Palmitate-preloaded cells exhibited significant increase in MCP-1 release and triglyceride (TG) deposition. Palmitates 9-18 C-C motif chemokine ligand 2 Homo sapiens 69-74 29713651-8 2018 In contrast, MCP-1 release suppression was abolished by the AMPK inhibitor compound C and the MEK inhibitor U0126. U 0126 108-113 C-C motif chemokine ligand 2 Homo sapiens 13-18 29518977-6 2018 HRas, p38, CCL2, DOK1, PTK2B and JNK3 were integrated into a model of resistance-associated signalling alterations describing differential gene and protein expression between cisplatin-sensitive and -resistant cells in reaction to cisplatin exposure. Cisplatin 175-184 C-C motif chemokine ligand 2 Homo sapiens 11-15 29518977-6 2018 HRas, p38, CCL2, DOK1, PTK2B and JNK3 were integrated into a model of resistance-associated signalling alterations describing differential gene and protein expression between cisplatin-sensitive and -resistant cells in reaction to cisplatin exposure. Cisplatin 231-240 C-C motif chemokine ligand 2 Homo sapiens 11-15 29274621-5 2018 The hypothesis of this study was that cannabinoids anandamide (AEA), HU-308 (CB2R selective agonist), and SMM-189 decrease pro-inflammatory IL-6 and MCP-1 production by primary human periodontal ligament fibroblasts (hPDLFs) stimulated with P. gingivalis LPS, TNF-alpha, or IL-1beta. Cannabinoids 38-50 C-C motif chemokine ligand 2 Homo sapiens 149-154 29513760-6 2018 Several inflammatory molecules upregulated by tumor necrosis factor-alpha in human retinal vascular endothelial cells were markedly reduced by metformin, including nuclear factor kappa B p65 (NFkappaB p65), intercellular adhesion molecule-1 (ICAM-1), monocyte chemotactic protein-1 (MCP-1), and interleukin-8 (IL-8). Metformin 143-152 C-C motif chemokine ligand 2 Homo sapiens 251-281 29513760-6 2018 Several inflammatory molecules upregulated by tumor necrosis factor-alpha in human retinal vascular endothelial cells were markedly reduced by metformin, including nuclear factor kappa B p65 (NFkappaB p65), intercellular adhesion molecule-1 (ICAM-1), monocyte chemotactic protein-1 (MCP-1), and interleukin-8 (IL-8). Metformin 143-152 C-C motif chemokine ligand 2 Homo sapiens 283-288 29513760-8 2018 Activation of AMP-activated protein kinase was found to play a partial role in the suppression of ICAM-1 and MCP-1 by metformin, but not in those of NFkappaB p65 and IL-8. Metformin 118-127 C-C motif chemokine ligand 2 Homo sapiens 109-114 29274621-9 2018 LPS (1 mug/ml), TNF-alpha (10 ng/ml), and IL-1beta (1 ng/ml) increased IL-6 and MCP-1 production, which were inhibited by AEA, SMM-189, and HU-308. anandamide 122-125 C-C motif chemokine ligand 2 Homo sapiens 80-85 29678838-4 2018 RESULTS: Treatment of human retinal Muller cells with high-glucose induced significant upregulation of ROCK-1, VEGF, and MCP-1/CCL2. Glucose 59-66 C-C motif chemokine ligand 2 Homo sapiens 121-126 29678838-4 2018 RESULTS: Treatment of human retinal Muller cells with high-glucose induced significant upregulation of ROCK-1, VEGF, and MCP-1/CCL2. Glucose 59-66 C-C motif chemokine ligand 2 Homo sapiens 127-131 29274621-5 2018 The hypothesis of this study was that cannabinoids anandamide (AEA), HU-308 (CB2R selective agonist), and SMM-189 decrease pro-inflammatory IL-6 and MCP-1 production by primary human periodontal ligament fibroblasts (hPDLFs) stimulated with P. gingivalis LPS, TNF-alpha, or IL-1beta. anandamide 51-61 C-C motif chemokine ligand 2 Homo sapiens 149-154 29274621-5 2018 The hypothesis of this study was that cannabinoids anandamide (AEA), HU-308 (CB2R selective agonist), and SMM-189 decrease pro-inflammatory IL-6 and MCP-1 production by primary human periodontal ligament fibroblasts (hPDLFs) stimulated with P. gingivalis LPS, TNF-alpha, or IL-1beta. anandamide 63-66 C-C motif chemokine ligand 2 Homo sapiens 149-154 29274621-5 2018 The hypothesis of this study was that cannabinoids anandamide (AEA), HU-308 (CB2R selective agonist), and SMM-189 decrease pro-inflammatory IL-6 and MCP-1 production by primary human periodontal ligament fibroblasts (hPDLFs) stimulated with P. gingivalis LPS, TNF-alpha, or IL-1beta. HU 308 69-75 C-C motif chemokine ligand 2 Homo sapiens 149-154 28765037-0 2018 Vitamin D effects on monocytes" CCL-2, IL6 and CD14 transcription in Addison"s disease and HLA susceptibility. Vitamin D 0-9 C-C motif chemokine ligand 2 Homo sapiens 32-37 29146238-11 2018 Protein array analyses revealed only minor changes to cytokine profiles when morphine was administered acutely or repeatedly; however, 24 h post morphine administration, the expression of several cytokines was greatly increased, including endogenous CCR5 chemokine ligands (CCL3, CCL4, and CCL5), as well as CCL2. Morphine 77-85 C-C motif chemokine ligand 2 Homo sapiens 308-312 29520786-9 2018 IL-8 and monocyte chemotactic protein-1 mRNA expression could be suppressed by the vitamin D pathway. Vitamin D 83-92 C-C motif chemokine ligand 2 Homo sapiens 9-39 29629347-4 2018 The purpose of this study was to determine whether beta-carotene regulates the expression of adipokines, such as adiponectin, monocyte chemoattractant protein-1 (MCP-1), and regulated on activation, normal T cell expressed and secreted (RANTES) in 3T3-L1 adipocytes treated with glucose/glucose oxidase (G/GO). beta Carotene 51-64 C-C motif chemokine ligand 2 Homo sapiens 126-160 29629347-4 2018 The purpose of this study was to determine whether beta-carotene regulates the expression of adipokines, such as adiponectin, monocyte chemoattractant protein-1 (MCP-1), and regulated on activation, normal T cell expressed and secreted (RANTES) in 3T3-L1 adipocytes treated with glucose/glucose oxidase (G/GO). beta Carotene 51-64 C-C motif chemokine ligand 2 Homo sapiens 162-167 29629347-11 2018 G/GO-induced dysregulation of adiponectin, MCP-1, and RANTES were significantly recovered by treatment with beta-carotene. beta Carotene 108-121 C-C motif chemokine ligand 2 Homo sapiens 43-48 29629347-12 2018 Conclusions: beta-Carotene inhibits oxidative stress-induced inflammation by suppressing pro-inflammatory adipokines MCP-1 and RANTES, and by enhancing adiponectin in adipocytes. beta Carotene 13-26 C-C motif chemokine ligand 2 Homo sapiens 117-122 28765037-8 2018 We found a downregulation of CCL-2 after vitamin D treatment in IL1beta-stimulated monocytes both from AD patients and HC (AD p<0.001; HC p<0.0001). Vitamin D 41-50 C-C motif chemokine ligand 2 Homo sapiens 29-34 29444128-7 2018 Regardless of the type of keratinocyte stimulation used, reduction of cytokine IL-8, IL-20 and CCL2 production (both at RNA and protein level) following genistein treatment was visible. Genistein 153-162 C-C motif chemokine ligand 2 Homo sapiens 95-99 29773098-9 2018 Pre-treatment with EX-527 attenuated the inhibitory effects of polydatin on the proliferation of MDMs, inhibited the expressions of SIRT1, promoted the expressions of MCP-1, TNF-alpha and IL-6. 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide 19-25 C-C motif chemokine ligand 2 Homo sapiens 167-172 29495330-6 2018 (3) Results: Generally, serum individual and total carotenoids were significantly and inversely associated with retinol-adjusted RBP4, RBP4, hsCRP, MCP1, and TNF-alpha levels. Carotenoids 51-62 C-C motif chemokine ligand 2 Homo sapiens 148-152 29495330-9 2018 Among the individual carotenoids, those with the most predominant association were lutein-zeaxanthin and total carotenoids for retinol-adjusted RBP4 and RBP4, alpha- and beta-carotene for hsCRP, and alpha-carotene for MCP1 and TNF-alpha. Carotenoids 21-32 C-C motif chemokine ligand 2 Homo sapiens 218-222 29495330-11 2018 (4) Conclusions: Serum carotenoids were inversely associated with RBP4, hsCRP, MCP1 and TNF-alpha among middle-aged and elderly Chinese adults. Carotenoids 23-34 C-C motif chemokine ligand 2 Homo sapiens 79-83 29643980-5 2018 In human keratinocytes, we found that perillaldehyde (1) inhibited BaP-induced AHR activation and ROS production, (2) inhibited BaP/AHR-mediated release of the CCL2 chemokine, and (3) activated the NRF2/HO1 antioxidant pathway. perillaldehyde 38-52 C-C motif chemokine ligand 2 Homo sapiens 160-164 29164336-7 2018 RESULTS: The secretion of CCL5 and CCL2 was stimulated in undifferentiated and decidualized ESCs by the combination of TNF-alpha and IFN-gamma under non-apoptotic as well as apoptotic (with Fas-stimulation in parallel) conditions. ammonium ferrous sulfate 190-193 C-C motif chemokine ligand 2 Homo sapiens 35-39 29420219-7 2018 In human aortic endothelial cells, neopterin reduced proliferation and TNF-alpha (tumor necrosis factor alpha)-induced upregulation of MCP-1 (monocyte chemotactic protein 1), ICAM-1 (intercellular adhesion molecule 1), and VCAM-1 (vascular cell adhesion molecule 1). Neopterin 35-44 C-C motif chemokine ligand 2 Homo sapiens 135-140 29420219-7 2018 In human aortic endothelial cells, neopterin reduced proliferation and TNF-alpha (tumor necrosis factor alpha)-induced upregulation of MCP-1 (monocyte chemotactic protein 1), ICAM-1 (intercellular adhesion molecule 1), and VCAM-1 (vascular cell adhesion molecule 1). Neopterin 35-44 C-C motif chemokine ligand 2 Homo sapiens 142-172 28852907-7 2018 HK-2 cells with high glucose up-regulated IL-6 and MCP-1 in a dose- and time-dependent manner, and SUV39H1 expression was reduced with greater glucose and prolonged stimulation. Glucose 21-28 C-C motif chemokine ligand 2 Homo sapiens 51-56 29241586-2 2018 In this work, we tested the hypothesis that cellular cholesterol alters chemotactic response of monocytes to Monocyte Chemoattractant Protein-1 (MCP-1) due to their effect on the receptor, CCR2. Cholesterol 53-64 C-C motif chemokine ligand 2 Homo sapiens 109-143 29241586-2 2018 In this work, we tested the hypothesis that cellular cholesterol alters chemotactic response of monocytes to Monocyte Chemoattractant Protein-1 (MCP-1) due to their effect on the receptor, CCR2. Cholesterol 53-64 C-C motif chemokine ligand 2 Homo sapiens 145-150 29241586-4 2018 Compared to untreated cells, cholesterol enrichment increased the number of monocytes transmigrated in response to MCP-1 while depletion had opposite effect. Cholesterol 29-40 C-C motif chemokine ligand 2 Homo sapiens 115-120 29406285-5 2018 Clarithromycin significantly suppressed the induction of serum MCP-1 and MMP-9 and vascular hyperpermeability in these organs in the early phase of infection, but did not suppress the induction of trypsin, IL-6 or IFN-gamma. Clarithromycin 0-14 C-C motif chemokine ligand 2 Homo sapiens 63-68 29406285-7 2018 These results suggest that clarithromycin suppresses infection-related inflammation and reduces vascular hyperpermeability by suppressing the induction of MCP-1 and MMP-9. Clarithromycin 27-41 C-C motif chemokine ligand 2 Homo sapiens 155-160 29231123-12 2018 This minireview highlights several proteins (kidney injury molecule-1, beta-2-microglobulin, neutrophil gelatinase-associated lipocalin, calbindin, monocyte chemotactic protein-1, trefoil factor 3) with the greatest promise for detecting cisplatin-induced acute kidney injury in humans. Cisplatin 238-247 C-C motif chemokine ligand 2 Homo sapiens 148-196 29107385-7 2018 Therefore, CCL2 secreted from the tumor microenvironment may attract and interact with monocytes/macrophages, and favor Th2 accumulation by inducing CCL22 secretion. th2 120-123 C-C motif chemokine ligand 2 Homo sapiens 11-15 29162452-7 2018 Taken together, we speculate that DT-13 inhibits endothelium vascular inflammation through regulating nitric oxide production and the expression of ROS, TNFR, IL-8, MCP-1, which are associated with inflammation. DT-13 34-39 C-C motif chemokine ligand 2 Homo sapiens 165-170 29386061-0 2018 Dihydroisotanshinone I combined with radiation inhibits the migration ability of prostate cancer cells through DNA damage and CCL2 pathway. dihydroisotanshinone I 0-22 C-C motif chemokine ligand 2 Homo sapiens 126-130 29386061-8 2018 Mechanistically, DT and the combination treatment reduced the secretion of chemokine (C-C Motif) Ligand 2 (CCL2) from prostate cancer cells. dihydroisotanshinone I 17-19 C-C motif chemokine ligand 2 Homo sapiens 75-105 29386061-8 2018 Mechanistically, DT and the combination treatment reduced the secretion of chemokine (C-C Motif) Ligand 2 (CCL2) from prostate cancer cells. dihydroisotanshinone I 17-19 C-C motif chemokine ligand 2 Homo sapiens 107-111 29386061-10 2018 CONCLUSIONS: DT displays radiosensitization and antimigration effects in prostate cancer cells by inducing DNA damage and inhibiting CCL2 secretion. dihydroisotanshinone I 13-15 C-C motif chemokine ligand 2 Homo sapiens 133-137 30215534-8 2018 Suppression of LPS-induced Il6 and Ccl2 genes by CpdA in macrophages is hampered upon Sqstm1 silencing, confirming that SQSTM1 is essential for the anti-inflammatory capacity of CpdA, at least in this cell type. CPDA 49-53 C-C motif chemokine ligand 2 Homo sapiens 35-39 29162452-5 2018 Enzyme-linked immunosorbent assay (ELISA) results demonstrated that DT-13 could suppress the TNF-alpha-induced upregulation of reactive oxygen species (ROS), tumor necrosis factor receptor (TNFR), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and nitric oxide in vivo dose-dependently and suppressed production of nitric oxide in vitro as shown by DAF-FMDA. DT-13 68-73 C-C motif chemokine ligand 2 Homo sapiens 219-253 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 C-C motif chemokine ligand 2 Homo sapiens 221-226 29191392-7 2018 RESULTS: We observed that CAP significantly induces the expression of Artemin, EGF, EG-VEGF (PK1), Endothelin-1 (ET-1), FGF-2 (FGF basic), IL-8 (CXCL8) and uPA in keratinocytes and Angiogenin (ANG), Endostatin (Col18A1), MCP-1 (CCL2), MMP-9, TIMP-1, uPA and VEGF in fibroblasts. cap 26-29 C-C motif chemokine ligand 2 Homo sapiens 228-232 29379059-12 2018 Taken together, targeting a reduction of MCP-1 opens the door to a better understanding of the mechanistic consequences of ceramide accumulation and may even delay the progression of FD in some organ systems. Ceramides 123-131 C-C motif chemokine ligand 2 Homo sapiens 41-46 29497482-11 2017 In MDA-MB-231 cells high fractional oxygen increased secretion of angiogenesis factors monocyte chemotactic protein 1, regulated on activation normal T-cell expressed and vascular endothelial growth factor. Oxygen 36-42 C-C motif chemokine ligand 2 Homo sapiens 87-117 29113965-8 2018 The increased mitochondrial reactive oxygen species levels of atherosclerotic-MSCs promoted a phenotypic switch characterized by enhanced glycolysis and an altered cytokine secretion (interleukin-6 P<0.0001, interleukin-8/C-X-C motif chemokine ligand 8 P=0.04, and monocyte chemoattractant protein-1/chemokine ligand 2 P=0.01). Reactive Oxygen Species 28-51 C-C motif chemokine ligand 2 Homo sapiens 268-302 29113965-9 2018 Furthermore, treatment of atherosclerotic-MSCs with the reactive oxygen species scavenger N-acetyl-l-cysteine reduced the levels of interleukin-6, interleukin-8/C-X-C motif chemokine ligand 8, and monocyte chemoattractant protein-1/chemokine ligand 2 in the MSC secretome and improved MSCs immunosuppressive capacity (P=0.03). Reactive Oxygen Species 56-79 C-C motif chemokine ligand 2 Homo sapiens 197-231 29113965-9 2018 Furthermore, treatment of atherosclerotic-MSCs with the reactive oxygen species scavenger N-acetyl-l-cysteine reduced the levels of interleukin-6, interleukin-8/C-X-C motif chemokine ligand 8, and monocyte chemoattractant protein-1/chemokine ligand 2 in the MSC secretome and improved MSCs immunosuppressive capacity (P=0.03). Acetylcysteine 90-109 C-C motif chemokine ligand 2 Homo sapiens 197-231 29162452-5 2018 Enzyme-linked immunosorbent assay (ELISA) results demonstrated that DT-13 could suppress the TNF-alpha-induced upregulation of reactive oxygen species (ROS), tumor necrosis factor receptor (TNFR), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and nitric oxide in vivo dose-dependently and suppressed production of nitric oxide in vitro as shown by DAF-FMDA. DT-13 68-73 C-C motif chemokine ligand 2 Homo sapiens 255-260 30333430-3 2018 The addition of gnetin C (10 muM) to the media moderately reduced the CCL2 production and markedly suppressed CCL5 production in both cells. gnetin C 16-24 C-C motif chemokine ligand 2 Homo sapiens 70-74 30068872-11 2018 Furthermore, DBM effectively inhibited the expression of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta), IL-6, and monocyte chemoattractant protein-1 (MCP-1). dibenzoylmethane 13-16 C-C motif chemokine ligand 2 Homo sapiens 174-208 30068872-11 2018 Furthermore, DBM effectively inhibited the expression of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1beta), IL-6, and monocyte chemoattractant protein-1 (MCP-1). dibenzoylmethane 13-16 C-C motif chemokine ligand 2 Homo sapiens 210-215 28914666-5 2018 The pleiotropic nonselective MCP-1/CCR2 inhibition by current pharmacological agents is thought to contribute to their anti-inflammatory and antiatherosclerotic effects that is also seen for nutraceutical compounds such as curcumin. Curcumin 223-231 C-C motif chemokine ligand 2 Homo sapiens 29-34 30064139-10 2018 RESULTS: Zedoarondiol attenuated HUVECs injury, up-regulated SOD activity, suppressed formation of MDA and ROS, and secretion and protein expression of IL-1beta, TNF-alpha, and MCP-1 in injured HUVECs induced by ox-LDL. zedoarondiol 9-21 C-C motif chemokine ligand 2 Homo sapiens 177-182 29030692-7 2018 The MCP-1, PDGF-AA, and VEGF levels decreased significantly in the IVBe + STTA group (p = 0.013, p = 0.004 and p = 0.018 respectively), but only the VEGF level decreased in the IVBe group (p = 0.001). 3-Buten-2-one, 1,1,1-trifluoro-4-mercapto-4-(2-thienyl)- 74-78 C-C motif chemokine ligand 2 Homo sapiens 4-9 29236160-4 2018 In this chapter, we will focus on key cytokines (e.g., IL-1, IL-6, TNF-alpha) and chemokines (e.g., MCP-1/CCL2) that mediate the ethanol-induced neuroimmune responses. Ethanol 129-136 C-C motif chemokine ligand 2 Homo sapiens 100-105 29236160-4 2018 In this chapter, we will focus on key cytokines (e.g., IL-1, IL-6, TNF-alpha) and chemokines (e.g., MCP-1/CCL2) that mediate the ethanol-induced neuroimmune responses. Ethanol 129-136 C-C motif chemokine ligand 2 Homo sapiens 106-110 29030692-9 2018 CONCLUSION: Intravitreal bevacizumab and subtenon triamcinolone injection reduces the VEGF, MCP-1 and PDGF-AA levels and increases the IL-8 level in the plural cytokine profiles of patients with DME, which might explain the limited therapeutic effect of combination therapy. Triamcinolone 50-63 C-C motif chemokine ligand 2 Homo sapiens 92-97 29132256-0 2018 MCP-1 produced by keratinocytes is associated with leucocyte recruitment during elicitation of nickel-induced occupational allergic contact dermatitis. Nickel 95-101 C-C motif chemokine ligand 2 Homo sapiens 0-5 29439331-9 2018 Higher CSF sAbetaPPbeta levels were associated with higher plasma markers only (IL-8; MCP-1). sabetappbeta 11-23 C-C motif chemokine ligand 2 Homo sapiens 86-91 29115506-0 2018 Angiotensin II induces monocyte chemoattractant protein-1 expression by increasing reactive oxygen species-mediated activation of the nuclear factor-kappaB signaling pathway in osteoblasts. Reactive Oxygen Species 83-106 C-C motif chemokine ligand 2 Homo sapiens 23-57 29115506-6 2018 The results of the present study ndicated that Ang II upregulated MCP-1 expression in osteoblasts, which was mitigated by agonists of the AT1R, including olmesartan, a ROS scavenger N-acetylcysteine (NAC), ammonium pyrrolidinethiocarbamate (PDTC) and nuclear factor (NF)-kappaB, but not by the Ang II type 2 receptor antagonist, PD123319. olmesartan 154-164 C-C motif chemokine ligand 2 Homo sapiens 66-71 29115506-6 2018 The results of the present study ndicated that Ang II upregulated MCP-1 expression in osteoblasts, which was mitigated by agonists of the AT1R, including olmesartan, a ROS scavenger N-acetylcysteine (NAC), ammonium pyrrolidinethiocarbamate (PDTC) and nuclear factor (NF)-kappaB, but not by the Ang II type 2 receptor antagonist, PD123319. Reactive Oxygen Species 168-171 C-C motif chemokine ligand 2 Homo sapiens 66-71 29115506-6 2018 The results of the present study ndicated that Ang II upregulated MCP-1 expression in osteoblasts, which was mitigated by agonists of the AT1R, including olmesartan, a ROS scavenger N-acetylcysteine (NAC), ammonium pyrrolidinethiocarbamate (PDTC) and nuclear factor (NF)-kappaB, but not by the Ang II type 2 receptor antagonist, PD123319. Acetylcysteine 182-198 C-C motif chemokine ligand 2 Homo sapiens 66-71 29115506-6 2018 The results of the present study ndicated that Ang II upregulated MCP-1 expression in osteoblasts, which was mitigated by agonists of the AT1R, including olmesartan, a ROS scavenger N-acetylcysteine (NAC), ammonium pyrrolidinethiocarbamate (PDTC) and nuclear factor (NF)-kappaB, but not by the Ang II type 2 receptor antagonist, PD123319. Acetylcysteine 200-203 C-C motif chemokine ligand 2 Homo sapiens 66-71 29115506-6 2018 The results of the present study ndicated that Ang II upregulated MCP-1 expression in osteoblasts, which was mitigated by agonists of the AT1R, including olmesartan, a ROS scavenger N-acetylcysteine (NAC), ammonium pyrrolidinethiocarbamate (PDTC) and nuclear factor (NF)-kappaB, but not by the Ang II type 2 receptor antagonist, PD123319. ammonium pyrrolidinethiocarbamate 206-239 C-C motif chemokine ligand 2 Homo sapiens 66-71 29115506-6 2018 The results of the present study ndicated that Ang II upregulated MCP-1 expression in osteoblasts, which was mitigated by agonists of the AT1R, including olmesartan, a ROS scavenger N-acetylcysteine (NAC), ammonium pyrrolidinethiocarbamate (PDTC) and nuclear factor (NF)-kappaB, but not by the Ang II type 2 receptor antagonist, PD123319. prolinedithiocarbamate 241-245 C-C motif chemokine ligand 2 Homo sapiens 66-71 29115506-6 2018 The results of the present study ndicated that Ang II upregulated MCP-1 expression in osteoblasts, which was mitigated by agonists of the AT1R, including olmesartan, a ROS scavenger N-acetylcysteine (NAC), ammonium pyrrolidinethiocarbamate (PDTC) and nuclear factor (NF)-kappaB, but not by the Ang II type 2 receptor antagonist, PD123319. PD 123319 329-337 C-C motif chemokine ligand 2 Homo sapiens 66-71 29422964-7 2018 A specific phosphoinositide 3-kinase (PI3K) inhibitor, wortmannin, was used to test the effect of PI3K inhibition on the secretion of CCL-2 in gastric cancer. Wortmannin 55-65 C-C motif chemokine ligand 2 Homo sapiens 134-139 29422964-13 2018 Furthermore, it was demonstrated that CCL-2 mRNA and protein expression was significantly inhibited by treatment with the PI3K inhibitor wortmannin. Wortmannin 137-147 C-C motif chemokine ligand 2 Homo sapiens 38-43 28653238-6 2018 Furthermore, we found that ghrelin effectively suppressed TNF-alpha-induced inflammatory factors" (including ICAM-1, VCAM-1, MCP-1, and IL-1beta) expression through inhibiting AMPK phosphorylation and p65 expression both in HUVEC and THP-1. Ghrelin 27-34 C-C motif chemokine ligand 2 Homo sapiens 125-130 29115520-5 2018 The human HCC cell line MHCC-97H was treated with CCL2. mhcc-97h 24-32 C-C motif chemokine ligand 2 Homo sapiens 50-54 29115520-12 2018 Furthermore, pretreatment with cyclopamine or predepletion of Gli-1 by siRNA also eliminated the changes of Snail, vimentin and E-cadherin, and HCC invasion and EMT caused by CCL2. cyclopamine 31-42 C-C motif chemokine ligand 2 Homo sapiens 175-179 30362842-9 2018 At 15 ng/mL cut-off value, vitamin D was negatively correlated with MCP-1 (p = .0006). Vitamin D 27-36 C-C motif chemokine ligand 2 Homo sapiens 68-73 30362842-11 2018 MCP-1 was a risk factor for vitamin D deficiency (p < .0001). Vitamin D 28-37 C-C motif chemokine ligand 2 Homo sapiens 0-5 29132256-1 2018 To investigate the expression profile of monocyte chemoattractant peptide-1 (MCP-1) by keratinocytes after nickel exposure and to identify its role for leucocyte migration during nickel-induced occupational allergic contact dermatitis (OACD), 26 workers diagnosed with nickel-induced OACD were enrolled. Nickel 107-113 C-C motif chemokine ligand 2 Homo sapiens 41-75 29132256-1 2018 To investigate the expression profile of monocyte chemoattractant peptide-1 (MCP-1) by keratinocytes after nickel exposure and to identify its role for leucocyte migration during nickel-induced occupational allergic contact dermatitis (OACD), 26 workers diagnosed with nickel-induced OACD were enrolled. Nickel 107-113 C-C motif chemokine ligand 2 Homo sapiens 77-82 29132256-4 2018 The results showed that at positive nickel-challenged sites, strong expressions of MCP-1, both messenger RNA (mRNA) and protein, were detected in the basal keratinocytes during the early phase (24-48 h after nickel application), paralleled by the recruitment of CD68+ and CD45RO+ cells to the skin compartments. Nickel 36-42 C-C motif chemokine ligand 2 Homo sapiens 83-88 29132256-4 2018 The results showed that at positive nickel-challenged sites, strong expressions of MCP-1, both messenger RNA (mRNA) and protein, were detected in the basal keratinocytes during the early phase (24-48 h after nickel application), paralleled by the recruitment of CD68+ and CD45RO+ cells to the skin compartments. Nickel 208-214 C-C motif chemokine ligand 2 Homo sapiens 83-88 29132256-5 2018 The expressions of MCP-1 declined gradually in the late phase (72-96 h after nickel application). Nickel 77-83 C-C motif chemokine ligand 2 Homo sapiens 19-24 29132256-7 2018 The data indicated that a temporal expression pattern of MCP-1 produced by keratinocytes after nickel exposure was involved in the complex process of mononuclear cell infiltration during elicitation of nickel-induced OACD. Nickel 95-101 C-C motif chemokine ligand 2 Homo sapiens 57-62 29132256-7 2018 The data indicated that a temporal expression pattern of MCP-1 produced by keratinocytes after nickel exposure was involved in the complex process of mononuclear cell infiltration during elicitation of nickel-induced OACD. Nickel 202-208 C-C motif chemokine ligand 2 Homo sapiens 57-62 29236068-15 2017 To support the ability to inhibit p38 MAPK, the treatment of javamide-II-ethyl and -methyl esters could suppress the production of IL-8 and MCP-1 protein significantly by 22-73% (p < 0.05) in the differentiated THP-1 cells, and the inhibition was slightly stronger by the ethyl ester than the methyl ester. javamide-ii-ethyl and -methyl esters 61-97 C-C motif chemokine ligand 2 Homo sapiens 140-145 29267498-5 2017 As a result, ginsenoside Rg1 protected HK-2 cells from LPS-induced injury, as cell viability was increased, cell apoptosis was decreased, and the release of MCP-1, IL-1beta, IL-6, and TNF-alpha was reduced. Ginsenosides 13-24 C-C motif chemokine ligand 2 Homo sapiens 157-162 29258201-4 2017 Supplementation of the culture medium with particular fatty acids was found to have a promoting effect on cellular production of the cytokines IL-6, IL-8, GM-CSF, and MCP-1. Fatty Acids 54-65 C-C motif chemokine ligand 2 Homo sapiens 167-172 29236764-3 2017 27-Hydroxycholesterol (27OHChol), an oxysterol elevated with hypercholesterolemia, enhanced production of CCL2, known as MCP1, chemokine from monocytes/macrophages and migration of the monocytic cells, but the CCL2 production and the cell migration were reduced by treatment with dexamethasone. 27-hydroxycholesterol 0-21 C-C motif chemokine ligand 2 Homo sapiens 106-110 29236764-3 2017 27-Hydroxycholesterol (27OHChol), an oxysterol elevated with hypercholesterolemia, enhanced production of CCL2, known as MCP1, chemokine from monocytes/macrophages and migration of the monocytic cells, but the CCL2 production and the cell migration were reduced by treatment with dexamethasone. 27-hydroxycholesterol 0-21 C-C motif chemokine ligand 2 Homo sapiens 121-125 29236764-3 2017 27-Hydroxycholesterol (27OHChol), an oxysterol elevated with hypercholesterolemia, enhanced production of CCL2, known as MCP1, chemokine from monocytes/macrophages and migration of the monocytic cells, but the CCL2 production and the cell migration were reduced by treatment with dexamethasone. 27-hydroxycholesterol 0-21 C-C motif chemokine ligand 2 Homo sapiens 210-214 29236764-3 2017 27-Hydroxycholesterol (27OHChol), an oxysterol elevated with hypercholesterolemia, enhanced production of CCL2, known as MCP1, chemokine from monocytes/macrophages and migration of the monocytic cells, but the CCL2 production and the cell migration were reduced by treatment with dexamethasone. 27ohchol 23-31 C-C motif chemokine ligand 2 Homo sapiens 106-110 29236764-3 2017 27-Hydroxycholesterol (27OHChol), an oxysterol elevated with hypercholesterolemia, enhanced production of CCL2, known as MCP1, chemokine from monocytes/macrophages and migration of the monocytic cells, but the CCL2 production and the cell migration were reduced by treatment with dexamethasone. 27ohchol 23-31 C-C motif chemokine ligand 2 Homo sapiens 121-125 29236764-3 2017 27-Hydroxycholesterol (27OHChol), an oxysterol elevated with hypercholesterolemia, enhanced production of CCL2, known as MCP1, chemokine from monocytes/macrophages and migration of the monocytic cells, but the CCL2 production and the cell migration were reduced by treatment with dexamethasone. 27ohchol 23-31 C-C motif chemokine ligand 2 Homo sapiens 210-214 29236764-3 2017 27-Hydroxycholesterol (27OHChol), an oxysterol elevated with hypercholesterolemia, enhanced production of CCL2, known as MCP1, chemokine from monocytes/macrophages and migration of the monocytic cells, but the CCL2 production and the cell migration were reduced by treatment with dexamethasone. Dexamethasone 280-293 C-C motif chemokine ligand 2 Homo sapiens 106-110 29236764-3 2017 27-Hydroxycholesterol (27OHChol), an oxysterol elevated with hypercholesterolemia, enhanced production of CCL2, known as MCP1, chemokine from monocytes/macrophages and migration of the monocytic cells, but the CCL2 production and the cell migration were reduced by treatment with dexamethasone. Dexamethasone 280-293 C-C motif chemokine ligand 2 Homo sapiens 121-125 29236764-4 2017 Dexamethasone inhibited superproduction of CCL2 induced by 27OHChol plus LPS and attenuated transcription of matrix metalloproteinase 9 as well as secretion of its active gene product induced by 27OHChol. Dexamethasone 0-13 C-C motif chemokine ligand 2 Homo sapiens 43-47 29236764-4 2017 Dexamethasone inhibited superproduction of CCL2 induced by 27OHChol plus LPS and attenuated transcription of matrix metalloproteinase 9 as well as secretion of its active gene product induced by 27OHChol. 27ohchol 59-67 C-C motif chemokine ligand 2 Homo sapiens 43-47 29228979-8 2017 RESULTS: We demonstrate that bryostatin-1 induces secretion of chemokines CCL2 and IL-8 and proinflammatory cytokines IL-6 and GM-CSF, whereas their production is repressed by JQ1. bryostatin 1 29-41 C-C motif chemokine ligand 2 Homo sapiens 74-78 29236068-15 2017 To support the ability to inhibit p38 MAPK, the treatment of javamide-II-ethyl and -methyl esters could suppress the production of IL-8 and MCP-1 protein significantly by 22-73% (p < 0.05) in the differentiated THP-1 cells, and the inhibition was slightly stronger by the ethyl ester than the methyl ester. ethyl ester 85-96 C-C motif chemokine ligand 2 Homo sapiens 140-145 29236068-15 2017 To support the ability to inhibit p38 MAPK, the treatment of javamide-II-ethyl and -methyl esters could suppress the production of IL-8 and MCP-1 protein significantly by 22-73% (p < 0.05) in the differentiated THP-1 cells, and the inhibition was slightly stronger by the ethyl ester than the methyl ester. methyl ester 84-96 C-C motif chemokine ligand 2 Homo sapiens 140-145 28935574-7 2017 Taurocholate induced LPCs to release MCP-1, MIP1alpha, and RANTES into conditioned medium causing HSC chemotaxis, which was inhibited by anti-MIP1alpha. Taurocholic Acid 0-12 C-C motif chemokine ligand 2 Homo sapiens 37-42 28990058-7 2017 The results demonstrated that MCP-1 and IL-6 secretion, as well as TNF-alpha expression, were significantly increased following FFA treatment, which was attenuated by Rb1 in a dose-dependent manner. Fatty Acids, Nonesterified 128-131 C-C motif chemokine ligand 2 Homo sapiens 30-35 28866026-8 2017 In HRMECs, the expression levels of tumor necrosis factor (TNF)-alpha-induced monocyte chemoattractant protein (MCP)-1, intercellular adhesion molecule (ICAM)-1, and vascular cell adhesion molecule (VCAM)-1 were significantly suppressed by bezafibrate in a dose-dependent manner. Bezafibrate 240-251 C-C motif chemokine ligand 2 Homo sapiens 78-118 29141644-11 2017 CONCLUSIONS: Our findings provide the first evidence that the bacterial endotoxin LPS potentiates calcium mobilization and ERK/p38 MAPK pathway activation and leads to the secretion of the pro-inflammatory chemokine MCP-1 by inducing PAR-2 expression and its associated activity in vascular ECs. Calcium 98-105 C-C motif chemokine ligand 2 Homo sapiens 216-221 29076753-3 2017 Research shows that the more neurotoxic factor, pyroglutamate-Abetas, and the more important inflammatory mediators, pyroglutamate-CCL2, both contribute to the initiation of AD specifically and the generation of N-terminal intramolecular cyclization catalyzed by glutaminyl cyclase quality control, the over-expression of which correlates positively with the severity of AD. Pyrrolidonecarboxylic Acid 117-130 C-C motif chemokine ligand 2 Homo sapiens 131-135 29076753-4 2017 Subsequently, lowering pyroglutamate-Abetas and pyroglutamate-CCL2 levels by quality control inhibition using small molecule inhibitors could be expected as an amazing strategy for the prevention and treatment of AD. Pyrrolidonecarboxylic Acid 48-61 C-C motif chemokine ligand 2 Homo sapiens 62-66 28065790-5 2017 Moreover, oxidative stress was evidenced only after exposure to CS, with a decrease secretion of GRO-alpha from 8min and of IL-8 and MCP-1 after 48min exposure. Cesium 64-66 C-C motif chemokine ligand 2 Homo sapiens 133-138 29166648-11 2017 While the levels of monocyte chemoattractant protein 1 mRNA expressed by hypox-visASCs correlated positively with the body mass index and waist circumference of the subjects, the concentration of vascular endothelial growth factor present in hypox-visASC-conditioned culture medium decreased significantly with increasing plasma glucose. Glucose 329-336 C-C motif chemokine ligand 2 Homo sapiens 20-54 29038174-7 2017 Mechanistically, ZEB1 expression in TAMs induced their polarization toward an F4/80low pro-tumor phenotype, including direct activation of Ccr2 In turn, expression of ZEB1 by TAMs induced Ccl2, Cd74, and a mesenchymal/stem-like phenotype in cancer cells. tams 36-40 C-C motif chemokine ligand 2 Homo sapiens 188-192 29038174-7 2017 Mechanistically, ZEB1 expression in TAMs induced their polarization toward an F4/80low pro-tumor phenotype, including direct activation of Ccr2 In turn, expression of ZEB1 by TAMs induced Ccl2, Cd74, and a mesenchymal/stem-like phenotype in cancer cells. tams 175-179 C-C motif chemokine ligand 2 Homo sapiens 188-192 29123118-2 2017 Compared with polyester flat substrates having uniformly distributed homogenous pores (2D), three-dimensional polystyrene substrates with randomly oriented and interconnected pores of heterogeneous size (3D) stimulated the stromal secretion of IGF-1 while lessened the production of VEGFR-1, MCP-1 and IL-6. Polystyrenes 110-121 C-C motif chemokine ligand 2 Homo sapiens 292-297 28838848-6 2017 Moreover, EPA and DHA pretreatment diminished increased Monocyte Chemoattractant Protein-1 (MCP-1) and Tumor Necrosis Factor-alpha (TNF-alpha) release from SV under inflammatory conditions. Eicosapentaenoic Acid 10-13 C-C motif chemokine ligand 2 Homo sapiens 56-90 28598282-9 2017 Also, high glucose increased TRAF6, interleukin (IL)-6, TNF-alpha, and chemical chemokine ligand (CCL) 2 levels, whereas it decreased IL-10 level. Glucose 11-18 C-C motif chemokine ligand 2 Homo sapiens 80-104 28598282-12 2017 Overexpression of miR-126 significantly abrogated high glucose-induced secretion of proinflammatory cytokines such as IL-6, TNF-alpha, and CCL2 and promoted production of IL-10. Glucose 55-62 C-C motif chemokine ligand 2 Homo sapiens 139-143 28838848-6 2017 Moreover, EPA and DHA pretreatment diminished increased Monocyte Chemoattractant Protein-1 (MCP-1) and Tumor Necrosis Factor-alpha (TNF-alpha) release from SV under inflammatory conditions. Eicosapentaenoic Acid 10-13 C-C motif chemokine ligand 2 Homo sapiens 92-97 28838848-6 2017 Moreover, EPA and DHA pretreatment diminished increased Monocyte Chemoattractant Protein-1 (MCP-1) and Tumor Necrosis Factor-alpha (TNF-alpha) release from SV under inflammatory conditions. Docosahexaenoic Acids 18-21 C-C motif chemokine ligand 2 Homo sapiens 56-90 28838848-6 2017 Moreover, EPA and DHA pretreatment diminished increased Monocyte Chemoattractant Protein-1 (MCP-1) and Tumor Necrosis Factor-alpha (TNF-alpha) release from SV under inflammatory conditions. Docosahexaenoic Acids 18-21 C-C motif chemokine ligand 2 Homo sapiens 92-97 28867378-9 2017 Both ROS and PGZ significantly induced the release of adiponectin and inhibited release of MCP-1 from the fat. Rosiglitazone 5-8 C-C motif chemokine ligand 2 Homo sapiens 91-96 28867378-9 2017 Both ROS and PGZ significantly induced the release of adiponectin and inhibited release of MCP-1 from the fat. Pioglitazone 13-16 C-C motif chemokine ligand 2 Homo sapiens 91-96 29049420-8 2017 Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells. dapt 13-17 C-C motif chemokine ligand 2 Homo sapiens 93-98 29276352-0 2017 Pretreatment Serum MCP-1 Level Predicts Response to Risperidone in Schizophrenia. Risperidone 52-63 C-C motif chemokine ligand 2 Homo sapiens 19-24 29276352-8 2017 Pretreatment level of MCP-1 may serve as a biomarker indicating response to risperidone treatment. Risperidone 76-87 C-C motif chemokine ligand 2 Homo sapiens 22-27 29049420-8 2017 Furthermore, DAPT and LiCl decreased production of IL-1beta, TNF-alpha, IL-6, iNOS, Cox2 and MCP-1; however, IL-10 expression was increased notably in LiCl treated cells. Lithium Chloride 22-26 C-C motif chemokine ligand 2 Homo sapiens 93-98 28356286-5 2017 With early treatment, cisplatin nephrotoxicity was attenuated as evidenced by decreased blood urea nitrogen (BUN) and reduced apoptosis and tubular injury scores on day 3 Early treatment resulted in downregulation of intrarenal monocyte chemotactic protein-1 and IL-6 expression and upregulation of IL-10 and VEGF expression. Cisplatin 22-31 C-C motif chemokine ligand 2 Homo sapiens 228-258 28892713-7 2017 SA also impairs CAC function and increases pro-inflammatory molecule (IL-1beta, IL-6, IL-8, MCP-1 and TNFalpha) gene expression and secretion in CACs starting from 3 h of incubation. stearic acid 0-2 C-C motif chemokine ligand 2 Homo sapiens 92-97 28791341-0 2017 Apocynin protects mesangial cells from lipopolysaccharide-induced inflammation by exerting heme oxygenase 1-mediated monocyte chemoattractant protein-1 suppression. acetovanillone 0-8 C-C motif chemokine ligand 2 Homo sapiens 117-151 29093604-11 2017 Conclusion: Further in-depth studies are needed to investigate the functions of cytokines CCL2, CCL5 and IL-6 in endometrial cancer cells treated with paclitaxel. Paclitaxel 151-161 C-C motif chemokine ligand 2 Homo sapiens 90-94 29093604-9 2017 Secretion of the cytokines CCL5, CCL2 and IL-6 increased after paclitaxel treatment in several endometrial cancer cell lines, but no general effect on cytokine secretion was detected after heparin treatment. Paclitaxel 63-73 C-C motif chemokine ligand 2 Homo sapiens 33-37 28791341-10 2017 Inhibition of HO-1 with zinc protoporphyrin significantly abolished apocynin-induced suppression of MCP-1, indicating that HO-1 is significant in the suppression of MCP-1. zinc protoporphyrin 24-43 C-C motif chemokine ligand 2 Homo sapiens 100-105 28302706-6 2017 Mast cell degranulation by MCP-1 was prevented by the NO donor spermine-NONOate. spermine nitric oxide complex 63-79 C-C motif chemokine ligand 2 Homo sapiens 27-32 28791341-10 2017 Inhibition of HO-1 with zinc protoporphyrin significantly abolished apocynin-induced suppression of MCP-1, indicating that HO-1 is significant in the suppression of MCP-1. acetovanillone 68-76 C-C motif chemokine ligand 2 Homo sapiens 100-105 28791341-10 2017 Inhibition of HO-1 with zinc protoporphyrin significantly abolished apocynin-induced suppression of MCP-1, indicating that HO-1 is significant in the suppression of MCP-1. acetovanillone 68-76 C-C motif chemokine ligand 2 Homo sapiens 165-170 28886135-4 2017 Interestingly, treatment of patient PBMCs with the Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) agonist, CDDO-Me(bardoxolone methyl), reduced MCP-1 production but not IL-6 or Interleukin-10 (IL-10) secretion. bardoxolone methyl 111-118 C-C motif chemokine ligand 2 Homo sapiens 148-153 29033853-9 2017 Results: The major findings of these analyses were: (1) MCs secreted HMGB1 from the nucleus during exposure to high glucose levels; HMGB1 acted in an autocrine fashion on the MCs to promote the production of MCP-1 and IL-8; (2) HMGB1 had little effect on high-glucose-induced apoptosis of the MCs; and (3) HMGB1-mediated MCP-1 and IL-8 production depended on the activation of MAPK signaling pathways. mcs 175-178 C-C motif chemokine ligand 2 Homo sapiens 208-213 29033853-9 2017 Results: The major findings of these analyses were: (1) MCs secreted HMGB1 from the nucleus during exposure to high glucose levels; HMGB1 acted in an autocrine fashion on the MCs to promote the production of MCP-1 and IL-8; (2) HMGB1 had little effect on high-glucose-induced apoptosis of the MCs; and (3) HMGB1-mediated MCP-1 and IL-8 production depended on the activation of MAPK signaling pathways. mcs 175-178 C-C motif chemokine ligand 2 Homo sapiens 321-326 29033853-9 2017 Results: The major findings of these analyses were: (1) MCs secreted HMGB1 from the nucleus during exposure to high glucose levels; HMGB1 acted in an autocrine fashion on the MCs to promote the production of MCP-1 and IL-8; (2) HMGB1 had little effect on high-glucose-induced apoptosis of the MCs; and (3) HMGB1-mediated MCP-1 and IL-8 production depended on the activation of MAPK signaling pathways. mcs 175-178 C-C motif chemokine ligand 2 Homo sapiens 208-213 29033853-9 2017 Results: The major findings of these analyses were: (1) MCs secreted HMGB1 from the nucleus during exposure to high glucose levels; HMGB1 acted in an autocrine fashion on the MCs to promote the production of MCP-1 and IL-8; (2) HMGB1 had little effect on high-glucose-induced apoptosis of the MCs; and (3) HMGB1-mediated MCP-1 and IL-8 production depended on the activation of MAPK signaling pathways. mcs 175-178 C-C motif chemokine ligand 2 Homo sapiens 321-326 28950844-0 2017 Effect of simvastatin on monocyte chemoattractant protein-1 expression in endometriosis patients: a randomized controlled trial. Simvastatin 10-21 C-C motif chemokine ligand 2 Homo sapiens 25-59 28950844-2 2017 It is a cholesterol-lowering drug that acts by inhibiting HMG-CoA reductase, resulting in a decrease in mevalonate, a precursor of cholesterol and monocyte chemoattractant protein-1 (MCP-1). Cholesterol 8-19 C-C motif chemokine ligand 2 Homo sapiens 147-181 28950844-2 2017 It is a cholesterol-lowering drug that acts by inhibiting HMG-CoA reductase, resulting in a decrease in mevalonate, a precursor of cholesterol and monocyte chemoattractant protein-1 (MCP-1). Cholesterol 8-19 C-C motif chemokine ligand 2 Homo sapiens 183-188 28950844-2 2017 It is a cholesterol-lowering drug that acts by inhibiting HMG-CoA reductase, resulting in a decrease in mevalonate, a precursor of cholesterol and monocyte chemoattractant protein-1 (MCP-1). Mevalonic Acid 104-114 C-C motif chemokine ligand 2 Homo sapiens 147-181 28950844-2 2017 It is a cholesterol-lowering drug that acts by inhibiting HMG-CoA reductase, resulting in a decrease in mevalonate, a precursor of cholesterol and monocyte chemoattractant protein-1 (MCP-1). Mevalonic Acid 104-114 C-C motif chemokine ligand 2 Homo sapiens 183-188 28950844-3 2017 This study investigated the effect of pre-operative oral simvastatin administration on MCP-1 gene expression and serum MCP-1 protein levels in patients with endometriosis. Simvastatin 57-68 C-C motif chemokine ligand 2 Homo sapiens 87-92 28950844-10 2017 Serum MCP-1 levels following simvastatin treatment were higher than in samples obtained before treatment (297.89 +- 70.77 and 255.51 +- 63.79 pg/ml, respectively) (P = 0.01). Simvastatin 29-40 C-C motif chemokine ligand 2 Homo sapiens 6-11 28935932-6 2017 CBD significantly attenuated the alcohol feeding-induced serum transaminase elevations, hepatic inflammation (mRNA expressions of TNFalpha, MCP1, IL1beta, MIP2 and E-Selectin, and neutrophil accumulation), oxidative/nitrative stress (lipid peroxidation, 3-nitrotyrosine formation, and expression of reactive oxygen species generating enzyme NOX2). Alcohols 33-40 C-C motif chemokine ligand 2 Homo sapiens 140-144 28807849-13 2017 In addition, DT also blocked the colon cancer cells recruitment ability of macrophage by decreasing CCL2 secretion in macrophages. dihydroisotanshinone I 13-15 C-C motif chemokine ligand 2 Homo sapiens 100-104 29340323-8 2018 In human tubular epithelial HK-2 cells, IgG fractions containing anti-EPOR antibodies upregulated the expression of monocyte chemoattractant protein-1 mRNA under a high concentration of glucose. Glucose 186-193 C-C motif chemokine ligand 2 Homo sapiens 116-150 28878153-8 2017 The expression of several chemokine genes, including CCL2 , CXCL10 , CXCL12 , CCR2 and CXCR4 , was significantly changed after celastrol treatment. celastrol 127-136 C-C motif chemokine ligand 2 Homo sapiens 53-57 29033853-9 2017 Results: The major findings of these analyses were: (1) MCs secreted HMGB1 from the nucleus during exposure to high glucose levels; HMGB1 acted in an autocrine fashion on the MCs to promote the production of MCP-1 and IL-8; (2) HMGB1 had little effect on high-glucose-induced apoptosis of the MCs; and (3) HMGB1-mediated MCP-1 and IL-8 production depended on the activation of MAPK signaling pathways. mcs 56-59 C-C motif chemokine ligand 2 Homo sapiens 208-213 29033853-9 2017 Results: The major findings of these analyses were: (1) MCs secreted HMGB1 from the nucleus during exposure to high glucose levels; HMGB1 acted in an autocrine fashion on the MCs to promote the production of MCP-1 and IL-8; (2) HMGB1 had little effect on high-glucose-induced apoptosis of the MCs; and (3) HMGB1-mediated MCP-1 and IL-8 production depended on the activation of MAPK signaling pathways. mcs 56-59 C-C motif chemokine ligand 2 Homo sapiens 321-326 28928376-7 2017 Furthermore, Oligo-Fucoidan supplementation increases cancer cell death and attenuates the adverse effects induced by etoposide that decreases production of the pro-inflammatory cytokine IL-6 and chemokine CCL2/MCP-1. Etoposide 118-127 C-C motif chemokine ligand 2 Homo sapiens 206-210 28928376-7 2017 Furthermore, Oligo-Fucoidan supplementation increases cancer cell death and attenuates the adverse effects induced by etoposide that decreases production of the pro-inflammatory cytokine IL-6 and chemokine CCL2/MCP-1. Etoposide 118-127 C-C motif chemokine ligand 2 Homo sapiens 211-216 28690191-0 2017 Methyl (E)-(3-(3,4-dihydroxyphenyl)acryloyl)tryptophanate can suppress MCP-1 expression by inhibiting p38 MAP kinase and NF-kappaB in LPS-stimulated differentiated THP-1 cells. methyl (E)-(3-(3,4-dihydroxyphenyl)acryloyl)tryptophanate 0-57 C-C motif chemokine ligand 2 Homo sapiens 71-76 28886135-4 2017 Interestingly, treatment of patient PBMCs with the Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) agonist, CDDO-Me(bardoxolone methyl), reduced MCP-1 production but not IL-6 or Interleukin-10 (IL-10) secretion. 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid 119-130 C-C motif chemokine ligand 2 Homo sapiens 148-153 28886135-5 2017 In enriched monocytes from healthy donors, CDDO-Me(bardoxolone methyl) also reduced LPS-induced MCP1/CCL2 production but did not alter IL-6 or IL-10 secretion. bardoxolone methyl 43-50 C-C motif chemokine ligand 2 Homo sapiens 96-100 28886135-5 2017 In enriched monocytes from healthy donors, CDDO-Me(bardoxolone methyl) also reduced LPS-induced MCP1/CCL2 production but did not alter IL-6 or IL-10 secretion. bardoxolone methyl 43-50 C-C motif chemokine ligand 2 Homo sapiens 101-105 28886135-5 2017 In enriched monocytes from healthy donors, CDDO-Me(bardoxolone methyl) also reduced LPS-induced MCP1/CCL2 production but did not alter IL-6 or IL-10 secretion. 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid 51-62 C-C motif chemokine ligand 2 Homo sapiens 96-100 28886135-5 2017 In enriched monocytes from healthy donors, CDDO-Me(bardoxolone methyl) also reduced LPS-induced MCP1/CCL2 production but did not alter IL-6 or IL-10 secretion. 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid 51-62 C-C motif chemokine ligand 2 Homo sapiens 101-105 28051087-3 2017 Compared with samples from unexposed women in the mid-luteal phase, depot-medroxyprogesterone acetate use was associated with: increased endocervical concentrations of MCP1 and IFNalpha2; decreased endocervical concentrations of IL1beta and IL6; increased proportions of endometrial CD4+ and CD8+ cells expressing the activation marker HLADR; increased density of endometrial macrophages; and decreased density of endometrial regulatory T cells. Medroxyprogesterone Acetate 74-101 C-C motif chemokine ligand 2 Homo sapiens 168-172 27932554-6 2017 Overall, our results suggest that EVT significantly increases IL-6, MCP-1, and TNF-alpha levels in the ischemic leg, but this effect is not associated with a higher rate of in-stent restenosis. EVT 34-37 C-C motif chemokine ligand 2 Homo sapiens 68-73 28595117-8 2017 In general, the lowest values for all cytokines were found in EDTA samples, stored on crushed ice, centrifuged within 4h and thereafter stored at -80 C. MCP-1 and MIP-1beta levels were highest in heparin plasma and storage of blood for up to 4h at room temperature significantly increased the interleukin (IL)-2, IL-6, IL-8, IFN-gamma and GM-CSF levels in EDTA plasma, indicating post-sampling release. Edetic Acid 62-66 C-C motif chemokine ligand 2 Homo sapiens 153-158 28595117-8 2017 In general, the lowest values for all cytokines were found in EDTA samples, stored on crushed ice, centrifuged within 4h and thereafter stored at -80 C. MCP-1 and MIP-1beta levels were highest in heparin plasma and storage of blood for up to 4h at room temperature significantly increased the interleukin (IL)-2, IL-6, IL-8, IFN-gamma and GM-CSF levels in EDTA plasma, indicating post-sampling release. Edetic Acid 356-360 C-C motif chemokine ligand 2 Homo sapiens 153-158 28466979-7 2017 The production of IL-6 and MCP-1 cytokines was also dependent on the structure of PTFE that the macrophages interacted with, but in a time-dependent manner. Polytetrafluoroethylene 82-86 C-C motif chemokine ligand 2 Homo sapiens 27-32 28886321-1 2017 The monocyte chemoattractant protein-1 (MCP-1) gene polymorphism(-2518A&gt;G) in the regulatory region of the MCP-1 protein has been reported to be associated with cancer risk. Adenosine Monophosphate 72-75 C-C motif chemokine ligand 2 Homo sapiens 4-38 28886321-1 2017 The monocyte chemoattractant protein-1 (MCP-1) gene polymorphism(-2518A&gt;G) in the regulatory region of the MCP-1 protein has been reported to be associated with cancer risk. Adenosine Monophosphate 72-75 C-C motif chemokine ligand 2 Homo sapiens 40-45 28886321-1 2017 The monocyte chemoattractant protein-1 (MCP-1) gene polymorphism(-2518A&gt;G) in the regulatory region of the MCP-1 protein has been reported to be associated with cancer risk. Adenosine Monophosphate 72-75 C-C motif chemokine ligand 2 Homo sapiens 115-120 28886321-2 2017 In this study we aimed to investigate the relationship of MCP-1 (-2518A&gt;G) gene polymorphism and ovarian cancer. Adenosine Monophosphate 72-75 C-C motif chemokine ligand 2 Homo sapiens 58-63 28886321-5 2017 This study suggests that MCP-1 (-2518A&gt;G) AG genotype and G allele could be considered as risk factor for susceptibility to ovarian cancer. Adenosine Monophosphate 39-42 C-C motif chemokine ligand 2 Homo sapiens 25-30 28655771-3 2017 We found that, among the RhoGEFs tested, MCP1 induced tyrosine phosphorylation of p115 RhoGEF but not of PDZ RhoGEF or leukemia-associated RhoGEF in human aortic smooth muscle cells (HASMCs). Tyrosine 54-62 C-C motif chemokine ligand 2 Homo sapiens 41-45 28655771-9 2017 These findings suggest that p115 RhoGEF is critical for MCP1-induced HASMC migration and proliferation in vitro and for injury-induced neointima formation in vivo by modulating Rac1-NFATc1-cyclin D1-CDK6-PKN1-CDK4-PAK1 signaling. hasmc 69-74 C-C motif chemokine ligand 2 Homo sapiens 56-60 28739588-2 2017 Frequently, the activity of chemokines depends on a modified N-terminus as described for the N-terminus of CCL2 modified to a pGlu- (pyroglutamate) residue by QC (glutaminyl cyclase) activity. Pyrrolidonecarboxylic Acid 126-130 C-C motif chemokine ligand 2 Homo sapiens 107-111 28890654-0 2017 Chondroitin Sulfate Inhibits Monocyte Chemoattractant Protein-1 Release From 3T3-L1 Adipocytes: A New Treatment Opportunity for Obesity-Related Inflammation? Chondroitin Sulfates 0-19 C-C motif chemokine ligand 2 Homo sapiens 29-63 28890654-4 2017 At the same time, varying concentrations of chondroitin sulfate (CS) were added in a physiologically relevant range (10-200 microg/mL) to determine its impact on MCP-1 release. Chondroitin Sulfates 44-63 C-C motif chemokine ligand 2 Homo sapiens 162-167 28890654-4 2017 At the same time, varying concentrations of chondroitin sulfate (CS) were added in a physiologically relevant range (10-200 microg/mL) to determine its impact on MCP-1 release. Chondroitin Sulfates 65-67 C-C motif chemokine ligand 2 Homo sapiens 162-167 28890654-6 2017 Because the main action of MCP-1 is to induce monocyte migration, cultured THP-1 monocytes were used to test whether CS at the highest physiologically relevant concentration could inhibit cell migration induced by human recombinant MCP-1. Chondroitin Sulfates 117-119 C-C motif chemokine ligand 2 Homo sapiens 232-237 28890654-7 2017 Chondroitin sulfate (100-200 microg/mL) inhibited MCP-1 release from inflamed adipocytes in a dose-dependent manner (P < .01, 95% confidence interval [CI]: -5.89 to -3.858 at 100 microg/mL and P < .001, 95% CI: -6.028 to -3.996 at 200 microg/mL) but had no effect on MCP-1-driven chemotaxis of THP-1 monocytes. Chondroitin Sulfates 0-19 C-C motif chemokine ligand 2 Homo sapiens 50-55 28890654-7 2017 Chondroitin sulfate (100-200 microg/mL) inhibited MCP-1 release from inflamed adipocytes in a dose-dependent manner (P < .01, 95% confidence interval [CI]: -5.89 to -3.858 at 100 microg/mL and P < .001, 95% CI: -6.028 to -3.996 at 200 microg/mL) but had no effect on MCP-1-driven chemotaxis of THP-1 monocytes. Chondroitin Sulfates 0-19 C-C motif chemokine ligand 2 Homo sapiens 273-278 28890654-8 2017 In summary, CS could be expected to reduce macrophage infiltration into adipose tissue by reduction in adipocyte expression and release of MCP-1 and as such might reduce adipose tissue inflammation in response to pro-inflammatory stimuli such as LPS, now increasingly recognized to be relevant in vivo. Chondroitin Sulfates 12-14 C-C motif chemokine ligand 2 Homo sapiens 139-144 28739588-2 2017 Frequently, the activity of chemokines depends on a modified N-terminus as described for the N-terminus of CCL2 modified to a pGlu- (pyroglutamate) residue by QC (glutaminyl cyclase) activity. Pyrrolidonecarboxylic Acid 133-146 C-C motif chemokine ligand 2 Homo sapiens 107-111 28371087-9 2017 Gene expressions of inflammatory markers IL-8 and MCP1 were reduced after clopidogrel treatment (P<.05); however, only MCP-1 remained reduced at protein level. Clopidogrel 74-85 C-C motif chemokine ligand 2 Homo sapiens 50-54 28627412-5 2017 Mechanistic studies revealed that CCR2 is required for macrophages to activate phosphatidylinositol 3-kinase (PI3K)-AKT-mechanistic target of rapamycin (mTOR) signaling in response to its ligand monocyte chemoattractant protein 1 stimulation, whereas hypoxia-inducible factor (HIF)-1alpha is downstream of PI3K-AKT-mTOR signaling. Phosphatidylinositols 79-99 C-C motif chemokine ligand 2 Homo sapiens 195-229 27614743-0 2017 Clarithromycin attenuates the expression of monocyte chemoattractant protein-1 by activating toll-like receptor 4 in human mesangial cells. Clarithromycin 0-14 C-C motif chemokine ligand 2 Homo sapiens 44-78 28477980-11 2017 ROS scavenger N-acetyl-L-cysteine (NAC) and Akt inhibitor MK2206 reduced TNF-alpha-induced mRNA expression of MCP-1 and IL-6 in VAFs. Reactive Oxygen Species 0-3 C-C motif chemokine ligand 2 Homo sapiens 110-115 28477980-11 2017 ROS scavenger N-acetyl-L-cysteine (NAC) and Akt inhibitor MK2206 reduced TNF-alpha-induced mRNA expression of MCP-1 and IL-6 in VAFs. MK 2206 58-64 C-C motif chemokine ligand 2 Homo sapiens 110-115 28477980-12 2017 In vivo studies indicated that the expression of SIRT1, SIRT6 was decreased and the expression of MCP-1, IL-6 and IL-1beta was increased in carotid collar-induced vascular inflammation. carotid 140-147 C-C motif chemokine ligand 2 Homo sapiens 98-103 28499250-12 2017 The ox-LDLs and endo-PF treatment also produced significant overexpression of microRNA predicted target genes nerve growth factor, interleukin-6 and prostaglandin E synthase and overexpression of their downstream protein targets Mip1alpha and MCP1. endo-pf 16-23 C-C motif chemokine ligand 2 Homo sapiens 243-247 28425077-2 2017 We compared the effect of hemodialysis (HD) with enoxaparin as an anticoagulant and without systemic anticoagulation (heparin-grafted membrane-Evodial) on the release of monocyte chemoattractant protein 1 (MCP-1), endostatin (ES) and activin A (Act-A). Enoxaparin 49-59 C-C motif chemokine ligand 2 Homo sapiens 170-204 28425077-2 2017 We compared the effect of hemodialysis (HD) with enoxaparin as an anticoagulant and without systemic anticoagulation (heparin-grafted membrane-Evodial) on the release of monocyte chemoattractant protein 1 (MCP-1), endostatin (ES) and activin A (Act-A). Heparin 118-125 C-C motif chemokine ligand 2 Homo sapiens 170-204 28627644-0 2017 5-aza-2"-deoxycytidine promotes migration of acute monocytic leukemia cells via activation of CCL2-CCR2-ERK signaling pathway. Decitabine 0-22 C-C motif chemokine ligand 2 Homo sapiens 94-98 28627644-9 2017 Using reverse transcription-polymerase chain reaction, Western blot and enzyme-linked immunosorbent assay analyses, 5-Aza treatment was observed to upregulate the expression of chemokine (C-C motif) ligand 2 (CCL2) and C-C chemokine receptor type 2 (CCR2) in THP-1 cells. Decitabine 116-121 C-C motif chemokine ligand 2 Homo sapiens 177-207 28627644-9 2017 Using reverse transcription-polymerase chain reaction, Western blot and enzyme-linked immunosorbent assay analyses, 5-Aza treatment was observed to upregulate the expression of chemokine (C-C motif) ligand 2 (CCL2) and C-C chemokine receptor type 2 (CCR2) in THP-1 cells. Decitabine 116-121 C-C motif chemokine ligand 2 Homo sapiens 209-213 28627644-10 2017 In addition, the results demonstrated that CCL2 induced extracellular signal-regulated kinase (ERK) phosphorylation by CCR2 in 5-Aza-treated THP-1 cells. Decitabine 127-132 C-C motif chemokine ligand 2 Homo sapiens 43-47 28587938-8 2017 Etidronate also inhibited Pam3CSK4-induced MCP-1 and TNF-alpha production by THP-1 cells. Etidronic Acid 0-10 C-C motif chemokine ligand 2 Homo sapiens 43-48 28706958-11 2017 In the culture media of Pam3CSK4-stimulated cells, MCP-1 protein level was increased, which was suppressed in the presence of IkappaK inhibitors. ikappak 126-133 C-C motif chemokine ligand 2 Homo sapiens 51-56 28969039-12 2017 After lapatinib treatment, the release of CCL2, CCL21, VEGF and CXCL1 decreased in a dose-dependent manner. Lapatinib 6-15 C-C motif chemokine ligand 2 Homo sapiens 42-46 28693163-9 2017 MCP-1 induced tyrosine phosphorylation of mitogen-activated protein kinase in HKBML cells, as analyzed by western blotting. Tyrosine 14-22 C-C motif chemokine ligand 2 Homo sapiens 0-5 26996066-4 2017 Moreover, MCP-1 treatment reduced glycogen synthase kinase-3beta (GSK-3beta) activity via the MEK/ERK-mediated phosphorylation of serine-9 in MCF-7 cells. Serine 130-136 C-C motif chemokine ligand 2 Homo sapiens 10-15 26996066-5 2017 The inhibition of MEK/ERK by U0126 attenuated the MCP-1-induced phosphorylation of GSK-3beta and decreased the expression of Snail, an EMT-related transcription factor, leading to the inhibition of MCF-7 cell migration and invasion. U 0126 29-34 C-C motif chemokine ligand 2 Homo sapiens 50-55 28456077-5 2017 Based upon transcriptome analysis, the axis of miR-327/CCL2 in Schwann cells (SCs) was identified as a potential target of COS. oligochitosan 123-126 C-C motif chemokine ligand 2 Homo sapiens 55-59 28456077-6 2017 The following experiments have confirmed that COS stimulate CCL2 expression by down-regulating miR-327 in SCs. oligochitosan 46-49 C-C motif chemokine ligand 2 Homo sapiens 60-64 28157698-0 2017 Anti-cancer effect of danshen and dihydroisotanshinone I on prostate cancer: targeting the crosstalk between macrophages and cancer cells via inhibition of the STAT3/CCL2 signaling pathway. dihydroisotanshinone I 34-56 C-C motif chemokine ligand 2 Homo sapiens 166-170 28637505-7 2017 Salmeterol and formoterol exerted an inhibitory effect on the LPS-induced production of TNF-alpha, IL-6, CCL2, CCL3, and CCL4 in MDMs. Salmeterol Xinafoate 0-10 C-C motif chemokine ligand 2 Homo sapiens 105-109 28637505-7 2017 Salmeterol and formoterol exerted an inhibitory effect on the LPS-induced production of TNF-alpha, IL-6, CCL2, CCL3, and CCL4 in MDMs. Formoterol Fumarate 15-25 C-C motif chemokine ligand 2 Homo sapiens 105-109 29207614-6 2017 Second, 10 muM DT repressed the phosphorylation of signal transducer and activator of transcription 3 (STAT3), the protein expression of S-phase kinase associated protein-2 (Skp2), and the mRNA levels of STAT3-related genes, including chemokine (C-C motif) ligand 2 (CCL2). dihydroisotanshinone I 15-17 C-C motif chemokine ligand 2 Homo sapiens 235-265 29207614-6 2017 Second, 10 muM DT repressed the phosphorylation of signal transducer and activator of transcription 3 (STAT3), the protein expression of S-phase kinase associated protein-2 (Skp2), and the mRNA levels of STAT3-related genes, including chemokine (C-C motif) ligand 2 (CCL2). dihydroisotanshinone I 15-17 C-C motif chemokine ligand 2 Homo sapiens 267-271 29207614-7 2017 In addition, 10 muM DT suppressed the macrophage recruitment ability of lung cancer cells by reducing CCL2 secretion from both macrophages and lung cancer cells. dihydroisotanshinone I 20-22 C-C motif chemokine ligand 2 Homo sapiens 102-106 28157698-5 2017 Mechanistically, DT both diminished the ability of prostate cancer cells to recruit macrophages and reduced the secretion of chemokine (C-C motif) ligand 2 (CCL2) from both macrophages and prostate cancer cells in a dose-dependent manner. dihydroisotanshinone I 17-19 C-C motif chemokine ligand 2 Homo sapiens 125-155 28157698-5 2017 Mechanistically, DT both diminished the ability of prostate cancer cells to recruit macrophages and reduced the secretion of chemokine (C-C motif) ligand 2 (CCL2) from both macrophages and prostate cancer cells in a dose-dependent manner. dihydroisotanshinone I 17-19 C-C motif chemokine ligand 2 Homo sapiens 157-161 28157698-9 2017 Furthermore, DT can inhibit the migration of prostate cancer cells by interrupting the crosstalk between prostate cancer cells and macrophages via the inhibition of the CCL2/STAT3 axis. dihydroisotanshinone I 13-15 C-C motif chemokine ligand 2 Homo sapiens 169-173 28726203-2 2017 Migration of monocytes stimulated by cysteine-containing peptides (fragments of chemokines with free thiol group MCP-1 and fractalkine) was completely inhibited by apocinin and MEK/ERK blocker. Cysteine 37-45 C-C motif chemokine ligand 2 Homo sapiens 113-134 28730084-7 2017 RESULTS: Vitreous levels of IL-2, IL-5, MCP-1, TNF-alpha and IP-10 were significantly higher (P<0.05) in AACG group. aacg 108-112 C-C motif chemokine ligand 2 Homo sapiens 40-45 28535046-3 2017 Pretreatment with piceatannol also inhibited TNF-alpha-induced expression of interleukin-6 (IL-6) and MCP-1 at both mRNA and protein levels in the 3T3-L1 adipocytes. 3,3',4,5'-tetrahydroxystilbene 18-29 C-C motif chemokine ligand 2 Homo sapiens 102-107 28535046-2 2017 Piceatannol at 10 muM significantly reduced the release of inflammatory cytokines of TNF-alpha and monocyte chemoattractant protein-1 (MCP-1) by 19 and 31% in the cocultured system, respectively. 3,3',4,5'-tetrahydroxystilbene 0-11 C-C motif chemokine ligand 2 Homo sapiens 99-133 28535046-2 2017 Piceatannol at 10 muM significantly reduced the release of inflammatory cytokines of TNF-alpha and monocyte chemoattractant protein-1 (MCP-1) by 19 and 31% in the cocultured system, respectively. 3,3',4,5'-tetrahydroxystilbene 0-11 C-C motif chemokine ligand 2 Homo sapiens 135-140 28424406-9 2017 We demonstrated that CCL2 treatment promoted A549 cell viability, motility and invasion by upregulating MMP-9 expression and that this induction was significantly suppressed by CAS 445479-97-0. Calcium 177-180 C-C motif chemokine ligand 2 Homo sapiens 21-25 28726203-2 2017 Migration of monocytes stimulated by cysteine-containing peptides (fragments of chemokines with free thiol group MCP-1 and fractalkine) was completely inhibited by apocinin and MEK/ERK blocker. Sulfhydryl Compounds 101-106 C-C motif chemokine ligand 2 Homo sapiens 113-134 28726203-2 2017 Migration of monocytes stimulated by cysteine-containing peptides (fragments of chemokines with free thiol group MCP-1 and fractalkine) was completely inhibited by apocinin and MEK/ERK blocker. apocinin 164-172 C-C motif chemokine ligand 2 Homo sapiens 113-134 27190355-0 2017 Tolvaptan suppresses monocyte chemotactic protein-1 excretion in autosomal-dominant polycystic kidney disease. Tolvaptan 0-9 C-C motif chemokine ligand 2 Homo sapiens 21-51 28379580-9 2017 Results: At baseline, serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triacylglycerol (TAG), and monocyte chemotactic protein 1 concentrations were significantly associated with serum TSH concentrations. Thyrotropin 211-214 C-C motif chemokine ligand 2 Homo sapiens 124-154 28333279-14 2017 In human foetal membranes, PIM1 inhibitors SMI-4a and AZD1208 significantly decreased the expression of pro-inflammatory cytokine interleukin-6 (IL6) and chemokines CXCL8 and CCL2 mRNA and release, prostaglandin prostaglandin F2alpha (PGF2alpha) release, adhesion molecule intercellular adhesion molecule 1 mRNA expression and release, and oxidative stress marker 8-isoprostane release after stimulation with either LPS or flagellin. AZD1208 54-61 C-C motif chemokine ligand 2 Homo sapiens 175-179 28162907-5 2017 A chemical cAMP analog 8-Br-cAMP also inhibited ERK phosphorylation and TNF and MCP-1 release. Cyclic AMP 11-15 C-C motif chemokine ligand 2 Homo sapiens 80-85 28162907-5 2017 A chemical cAMP analog 8-Br-cAMP also inhibited ERK phosphorylation and TNF and MCP-1 release. 8-Bromo Cyclic Adenosine Monophosphate 23-32 C-C motif chemokine ligand 2 Homo sapiens 80-85 28162907-6 2017 As expected, MAPK/ERK kinase (MEK)1/2 inhibitor PD0325901 inhibited ERK phosphorylation and suppressed both TNF and MCP-1 production. mirdametinib 48-57 C-C motif chemokine ligand 2 Homo sapiens 116-121 27190355-4 2017 In a sub-analysis, we determined whether tolvaptan administration for up to 3 years changed the urinary excretion of MCP-1 referenced to creatinine in 869 treated subjects compared with 438 placebo subjects. Tolvaptan 41-50 C-C motif chemokine ligand 2 Homo sapiens 117-122 27190355-10 2017 Conclusion: Tolvaptan, administered for 3 years to patients with ADPKD, caused a sustained reduction in the urinary excretion of MCP-1 relative to placebo. Tolvaptan 12-21 C-C motif chemokine ligand 2 Homo sapiens 129-134 28555020-0 2017 N-Caffeoyltryptamine, a Potent Anti-Inflammatory Phenolic Amide, Suppressed MCP-1 Expression in LPS-stimulated THP-1 Cells and Rats Fed a High-Fat Diet. N-caffeoyltryptamine 0-20 C-C motif chemokine ligand 2 Homo sapiens 76-81 28555020-3 2017 Therefore, in this paper, the potential effect of N-caffeoyltryptamine on MCP-1 expression was investigated as a potential p38 mitogen-activated protein (MAP) kinase inhibitor in vitro and in vivo. N-caffeoyltryptamine 50-70 C-C motif chemokine ligand 2 Homo sapiens 74-79 28555020-5 2017 Also, the pretreatment of the lipopolysaccharide (LPS)-stimulated THP-1 cells with N-caffeoyltryptamine (10, 20 and 40 muM) led to significant suppression of MCP-1 production by 10-45% (p < 0.05) in the cells. N-caffeoyltryptamine 83-103 C-C motif chemokine ligand 2 Homo sapiens 158-163 28555020-11 2017 However, the MCP-1 levels of the HFS group were significantly lower than those of the HF group (p < 0.05), suggesting that N-caffeoyltryptamine could decrease MCP-1 expression in vivo. N-caffeoyltryptamine 126-146 C-C motif chemokine ligand 2 Homo sapiens 13-18 28555020-11 2017 However, the MCP-1 levels of the HFS group were significantly lower than those of the HF group (p < 0.05), suggesting that N-caffeoyltryptamine could decrease MCP-1 expression in vivo. N-caffeoyltryptamine 126-146 C-C motif chemokine ligand 2 Homo sapiens 162-167 28555020-13 2017 These data suggest that N-caffeoyltryptamine may specifically suppress MCP-1 expression in vitro and in vivo, possibly by inhibiting p38 MAP kinase. N-caffeoyltryptamine 24-44 C-C motif chemokine ligand 2 Homo sapiens 71-76 28302482-5 2017 Mechanistically, CAFs with high FAP expression promoted immunosuppression in the CRC tumor immune microenvironment by up-regulating CCL2 secretion, recruiting myeloid cells, and decreasing T-cell activity. cafs 17-21 C-C motif chemokine ligand 2 Homo sapiens 132-136 28475489-2 2017 Materials and methods Our study aimed to analyze the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, monocyte chemoattractant protein (MCP)-1 and IL-8 by whole blood cells following short-term exposure to epinephrine (Epi) and 17beta-estradiol (E2) in the presence or absence of lipopolysaccharide (LPS). Epinephrine 230-241 C-C motif chemokine ligand 2 Homo sapiens 126-166 28486961-6 2017 Heparin reduced the expression of pro-inflammatory markers (TNF-alpha and IL-6) in hAM and deactivated the NF-kss pathway in hATII, diminishing the expression of IRAK1 and MyD88 and their effectors, IL-6, MCP-1 and IL-8. Heparin 0-7 C-C motif chemokine ligand 2 Homo sapiens 205-210 28443720-9 2017 The induction of the expression of MMP-3 and the downregulation of MCP-1 might result in an antiplatelet activity that was not observed for the micronized purified flavonoid fraction. Flavonoids 164-173 C-C motif chemokine ligand 2 Homo sapiens 67-72 28293857-6 2017 RESULTS: Cilostazol demonstrated renoprotective effects in patients with diabetic nephropathy by reducing serum soluble adhesion molecule-1 and monocyte chemoattractant protein-1. Cilostazol 9-19 C-C motif chemokine ligand 2 Homo sapiens 120-178 28589165-9 2017 RESULTS: In both murine and human astrocytes, DMF, but not MMF, significantly reduced secretion of IL-6, CXCL10, and CCL2; neither fumarate promoted a robust increase in antioxidant gene expression, although both MMF and DMF prevented intracellular ROS production. Dimethyl Fumarate 46-49 C-C motif chemokine ligand 2 Homo sapiens 117-121 28577105-5 2017 Atorvastatin therapy significantly reduced the levels of VEGF (by 11%), C-reactive protein (by 26%), total cholesterol (by 30%), LDL cholesterol (by 35%), and triglycerides (by 18%); the levels of endostatin, MCP-1, and HDL cholesterol remained unchanged. Atorvastatin 0-12 C-C motif chemokine ligand 2 Homo sapiens 209-214 28391993-0 2017 Sodium azide suppresses LPS-induced expression MCP-1 through regulating IkappaBzeta and STAT1 activities in macrophages. Sodium Azide 0-12 C-C motif chemokine ligand 2 Homo sapiens 47-52 28391993-3 2017 Interestingly, the LPS-induced expression of monocyte chemoattractant protein (MCP)-1 was suppressed by NaN3 without affecting the expression of IL-8 and TNF-alpha. Sodium Azide 104-108 C-C motif chemokine ligand 2 Homo sapiens 45-85 28391993-4 2017 Further analysis of cellular signaling mediators involved in the expression of these cytokines revealed that NaN3 suppressed the LPS-induced activation of signal transducers and activator of transcription (STAT)1 and inhibitor of kappaB (IkappaB) sigma, which are involved in the LPS-induced expression of MCP-1, while the LPS-induced activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) was not affected. Sodium Azide 109-113 C-C motif chemokine ligand 2 Homo sapiens 306-311 28476406-4 2017 FINDINGS: Vitamin D3 significantly suppressed monocyte chemoattractant protein 1, macrophage inhibitory protein (MIP)-1alpha, MIP-1beta, regulated on activation, normal T-cell expressed and secreted (RANTES), and interferon-gamma inducible protein 10 (IP-10)-positive T-cell subsets compared with culture filtrate antigen stimulated cells without vitamin D3 treatment. Cholecalciferol 10-20 C-C motif chemokine ligand 2 Homo sapiens 46-80 27798431-6 2017 RESULTS: We show that, in contrast to RAL, ritonavir treatment significantly increases mRNA expression levels of HO-1, IL-8, TNFalpha, CCL5, and MCP-1 in vitro in a dose-dependent manner. Ritonavir 43-52 C-C motif chemokine ligand 2 Homo sapiens 145-150 28554965-2 2017 Here we show that Fetuin-A (FetA) or lipopolysaccharide (LPS) exacerbate palmitic acid-induced podocyte death, which is associated with a strong induction of monocyte chemoattractant protein-1 (MCP-1) and keratinocyte chemoattractant (KC). Palmitic Acid 73-86 C-C motif chemokine ligand 2 Homo sapiens 158-192 28554965-2 2017 Here we show that Fetuin-A (FetA) or lipopolysaccharide (LPS) exacerbate palmitic acid-induced podocyte death, which is associated with a strong induction of monocyte chemoattractant protein-1 (MCP-1) and keratinocyte chemoattractant (KC). Palmitic Acid 73-86 C-C motif chemokine ligand 2 Homo sapiens 194-199 28431555-11 2017 After 40 h exposure, EDTMP coated MOx show significant decreases of neutrophil counts, lactate dehydrogenase (LDH) release, MCP-1, LIX and IL-6 in bronchoalveolar lavage fluid (BALF), compared to uncoated particles. (ethylenedinitrilo)-tetramethylenephosphonic acid 21-26 C-C motif chemokine ligand 2 Homo sapiens 124-129 28322790-0 2017 Short-chain fatty acids, GPR41 and GPR43 ligands, inhibit TNF-alpha-induced MCP-1 expression by modulating p38 and JNK signaling pathways in human renal cortical epithelial cells. Fatty Acids, Volatile 0-23 C-C motif chemokine ligand 2 Homo sapiens 76-81 28322790-7 2017 SCFAs, especially propionate, attenuated TNF-alpha- stimulated MCP-1 expression by inhibiting the phosphorylation of p38 and JNK. Fatty Acids, Volatile 0-5 C-C motif chemokine ligand 2 Homo sapiens 63-68 28322790-7 2017 SCFAs, especially propionate, attenuated TNF-alpha- stimulated MCP-1 expression by inhibiting the phosphorylation of p38 and JNK. Propionates 18-28 C-C motif chemokine ligand 2 Homo sapiens 63-68 28431555-11 2017 After 40 h exposure, EDTMP coated MOx show significant decreases of neutrophil counts, lactate dehydrogenase (LDH) release, MCP-1, LIX and IL-6 in bronchoalveolar lavage fluid (BALF), compared to uncoated particles. MOX 34-37 C-C motif chemokine ligand 2 Homo sapiens 124-129 28232185-8 2017 LDL-C increased monocyte CCR2 expression, which augmented monocyte migration towards MCP-1. ldl-c 0-5 C-C motif chemokine ligand 2 Homo sapiens 85-90 28052863-5 2017 Poly(I:C) increased the production of IL-6, IL-8, monocyte chemoattractant protein-1, and ICAM-1. Poly I-C 0-8 C-C motif chemokine ligand 2 Homo sapiens 50-84 28380135-8 2017 A logistic regression model adjusted for body mass index (BMI), age, race, aldosterone levels, and presence of diabetes and RH demonstrated that median levels of MCP-1 (2.55 pg/mL [1.22 - 5.2 pg/mL], p = 0.01) were independently associated with LVH in the entire hypertensive population. Aldosterone 75-86 C-C motif chemokine ligand 2 Homo sapiens 162-167 28126596-3 2017 The results of cellular experiments confirmed that the gene expression of most inflammatory factors (IL-1, IL-6 and MCP-1) and growth factors (VEGF, PDGF and EGF) by macrophages were up-regulated to varying degrees by BCP ceramic and its degradation products. hydroxyapatite-beta tricalcium phosphate 218-221 C-C motif chemokine ligand 2 Homo sapiens 116-121 27896541-4 2017 Gomisin N inhibited interleukin (IL)-6, IL-8, CC chemokine ligand (CCL) 2, and CCL20 production in TNF-alpha-stimulated HPDLC in a dose-dependent manner. schizandrin B 0-9 C-C motif chemokine ligand 2 Homo sapiens 46-73 28366881-6 2017 We now demonstrate that exposure of either human macrophages or PBMCs to SP leads to increased production of chemokines, including MCP-1, for which expression is limited to cells of the myeloid lineage. TFF2 protein, human 73-75 C-C motif chemokine ligand 2 Homo sapiens 131-136 28366881-10 2017 Our results suggest that increased SP levels associated with HIV and other inflammatory conditions may contribute to increased monocyte migration into the CNS and other tissues through a MCP-1-dependent mechanism. TFF2 protein, human 35-37 C-C motif chemokine ligand 2 Homo sapiens 187-192 27393275-0 2017 Urinary MCP-1 HMGB1 increased in calcium nephrolithiasis patients and the influence of hypercalciuria on the production of the two cytokines. Calcium 33-40 C-C motif chemokine ligand 2 Homo sapiens 8-13 27393275-9 2017 Results showed that urinary MCP-1 and HMGB1 increased in calcium nephrolithiasis patients and hypercalciuria might affect the identical pathways (through the reactive oxygen species) with other factors in stimulating the production of MCP-1 and HMGB1 in vivo. Calcium 57-64 C-C motif chemokine ligand 2 Homo sapiens 28-33 27393275-9 2017 Results showed that urinary MCP-1 and HMGB1 increased in calcium nephrolithiasis patients and hypercalciuria might affect the identical pathways (through the reactive oxygen species) with other factors in stimulating the production of MCP-1 and HMGB1 in vivo. Reactive Oxygen Species 158-181 C-C motif chemokine ligand 2 Homo sapiens 28-33 27393275-9 2017 Results showed that urinary MCP-1 and HMGB1 increased in calcium nephrolithiasis patients and hypercalciuria might affect the identical pathways (through the reactive oxygen species) with other factors in stimulating the production of MCP-1 and HMGB1 in vivo. Reactive Oxygen Species 158-181 C-C motif chemokine ligand 2 Homo sapiens 235-240 28274716-3 2017 Here, We found that atractylenolide I inhibited Ox-LDL-induced VSMCs proliferation and migration in a dose-dependent manner, and decreased the production of inflammatory cytokines and the expression of monocyte chemoattractant protein-1 (MCP-1) in VSMCs. (+)-Atractylenolide 20-35 C-C motif chemokine ligand 2 Homo sapiens 202-236 28274716-3 2017 Here, We found that atractylenolide I inhibited Ox-LDL-induced VSMCs proliferation and migration in a dose-dependent manner, and decreased the production of inflammatory cytokines and the expression of monocyte chemoattractant protein-1 (MCP-1) in VSMCs. (+)-Atractylenolide 20-35 C-C motif chemokine ligand 2 Homo sapiens 238-243 28284222-6 2017 Upon treatment with teriflunomide, cytokine secretion was decreased (CXCL10, 3-fold; CCL2, 2.5-fold; IL-6, 2.2-fold; p < 0.001) and monomethylfumarate treatment led to 2.9-fold lower CXCL10 secretion (p < 0.001). teriflunomide 20-33 C-C motif chemokine ligand 2 Homo sapiens 85-89 28161330-0 2017 Testosterone increases CCL-2 expression in visceral adipose tissue from obese women of reproductive age. Testosterone 0-12 C-C motif chemokine ligand 2 Homo sapiens 23-28 28161330-19 2017 CONCLUSIONS: Testosterone increases CCL-2 expression in visceral adipose tissue from obese women of reproductive age. Testosterone 13-25 C-C motif chemokine ligand 2 Homo sapiens 36-41 28314697-5 2017 Upon FXa stimulation, the expressions of pro-inflammatory genes such as monocyte chemoattractant protein-1 (MCP-1), intracellular adhesion molecule-1, and interleukin-8 were maximally increased at 4 h after stimulation, and were suppressed by rivaroxaban. Rivaroxaban 243-254 C-C motif chemokine ligand 2 Homo sapiens 72-106 28024939-11 2017 RAGE or ER stress knockdown reduced the up-regulation of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) in human AVICs exposed to HMGB1.These novel findings demonstrate that RAGE deficiency protects against aortic valve calcification in high cholesterol diet-fed ApoE-/- mice via inhibition of ER stress. Cholesterol 282-293 C-C motif chemokine ligand 2 Homo sapiens 93-98 28278187-6 2017 Treatment with resveratrol significantly reduced the expression and secretion of pro-inflammatory cytokines IL-6, IL-1alpha, IL-1beta and pro-inflammatory chemokines IL-8 and MCP-1 in human placenta and omental and subcutaneous adipose tissue. Resveratrol 15-26 C-C motif chemokine ligand 2 Homo sapiens 175-180 27417275-13 2017 CONCLUSIONS: Intravitreal dexamethasone treatment resulted in alterations in the concentrations of pro-inflammatory cytokines MCP-1 and IL17-E in patients with BRVO and MCP-1 and IL1-alpha in patients with CRVO. Dexamethasone 26-39 C-C motif chemokine ligand 2 Homo sapiens 126-131 27417275-13 2017 CONCLUSIONS: Intravitreal dexamethasone treatment resulted in alterations in the concentrations of pro-inflammatory cytokines MCP-1 and IL17-E in patients with BRVO and MCP-1 and IL1-alpha in patients with CRVO. Dexamethasone 26-39 C-C motif chemokine ligand 2 Homo sapiens 169-174 28081470-7 2017 The expression level of cytokines and chemokines influenced by eleutheroside B1 was further demonstrated, the IL-6, CXCL-8, CCL-2 expression were all inhibited by the eleuthe roside B1 at concentration 200mug/ml. eleuthe roside b1 167-184 C-C motif chemokine ligand 2 Homo sapiens 124-129 28063327-9 2017 Only the correlation between FGF23 and MCP1 remained significant after adjustments for 25(OH) vitamin D and renal function. 25(oh) vitamin d 87-103 C-C motif chemokine ligand 2 Homo sapiens 39-43 28314697-5 2017 Upon FXa stimulation, the expressions of pro-inflammatory genes such as monocyte chemoattractant protein-1 (MCP-1), intracellular adhesion molecule-1, and interleukin-8 were maximally increased at 4 h after stimulation, and were suppressed by rivaroxaban. Rivaroxaban 243-254 C-C motif chemokine ligand 2 Homo sapiens 108-113 28314697-8 2017 Interestingly, rivaroxaban inhibited both time courses of MCP-1 expression. Rivaroxaban 15-26 C-C motif chemokine ligand 2 Homo sapiens 58-63 27655254-8 2017 NH4Cl also attenuated LPS-induced release of MCP-1, IL-6 and IL-10 in mono-cultured microglia. Ammonium Chloride 0-5 C-C motif chemokine ligand 2 Homo sapiens 45-50 28087464-5 2017 Furthermore, the mitochondrial ROS scavenger Mito-TEMPO, which inhibited MAPK and AP-1, significantly reduced MCP-1 and IL-1beta mRNA expression and reduced HL-60 cell migration through the suppression of MCP-1 and IL-8 protein secretion. Reactive Oxygen Species 31-34 C-C motif chemokine ligand 2 Homo sapiens 110-115 28087464-5 2017 Furthermore, the mitochondrial ROS scavenger Mito-TEMPO, which inhibited MAPK and AP-1, significantly reduced MCP-1 and IL-1beta mRNA expression and reduced HL-60 cell migration through the suppression of MCP-1 and IL-8 protein secretion. Reactive Oxygen Species 31-34 C-C motif chemokine ligand 2 Homo sapiens 205-210 28107185-7 2017 HAS3-derived HA release into extracellular milieu enhanced transendothelial monocyte migration and MCP-1 expression, which was attenuated by anti-HAS3 antibodies or a HAS inhibitor, 4-Methylumbelliferone (4-MU). Hymecromone 182-203 C-C motif chemokine ligand 2 Homo sapiens 99-104 28107185-7 2017 HAS3-derived HA release into extracellular milieu enhanced transendothelial monocyte migration and MCP-1 expression, which was attenuated by anti-HAS3 antibodies or a HAS inhibitor, 4-Methylumbelliferone (4-MU). Hymecromone 205-209 C-C motif chemokine ligand 2 Homo sapiens 99-104 28231837-8 2017 RESULTS: PBMCs from nAMD patients secreted higher levels of IL-8, CCL2 and VEGF, especially following LPS and 1% oxygen stimulation, than those from controls. Oxygen 113-119 C-C motif chemokine ligand 2 Homo sapiens 66-70 28168393-9 2017 Further, alcohol-related increases (1.5-3.0 fold) were observed in the expression of hepatic cytokines (TNF-alpha, IL-1 beta, IL-6, IL-10) and other factors noted to be involved in the colonization of CRC cells including ICAM-1, CCL-2, CCL-7, MMP-2, and MMP-9. Alcohols 9-16 C-C motif chemokine ligand 2 Homo sapiens 229-234 28178994-11 2017 RESULTS: Doxycycline decreased plasma lysophosphatidate concentrations, delayed tumor growth and decreased the concentrations of several cytokines/chemokines (IL-1beta, IL-6, IL-9, CCL2, CCL11, CXCL1, CXCL2, CXCL9, G-CSF, LIF, VEGF) in the tumor. Doxycycline 9-20 C-C motif chemokine ligand 2 Homo sapiens 181-185 28039457-2 2017 We previously reported that TAMs promote prostate cancer metastasis via activation of the CCL2-CCR2 axis. tams 28-32 C-C motif chemokine ligand 2 Homo sapiens 90-94 27186953-5 2017 Unexpectedly, NaW further induced IL-6, IL-8, and MCP-1 secretion in both N- and D-RPTEC, together with lower levels of IL-1 RA, IL-4, IL-10, and GM-CSF, suggesting that it may contribute to the extent of renal damage/repair during DKD. naw 14-17 C-C motif chemokine ligand 2 Homo sapiens 50-55 28352316-3 2017 However, the role of spinal MCP-1 in the development of morphine tolerance in patients with cancer-induced bone pain remains unclear. Morphine 56-64 C-C motif chemokine ligand 2 Homo sapiens 28-33 27668844-0 2017 Sorafenib with ASC-J9 synergistically suppresses the HCC progression via altering the pSTAT3-CCL2/Bcl2 signals. Sorafenib 0-9 C-C motif chemokine ligand 2 Homo sapiens 94-98 27743775-0 2017 Curcumin as a natural regulator of monocyte chemoattractant protein-1. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 35-69 27743775-5 2017 The purpose of this review is to evaluate the effects of curcumin on the regulation of MCP-1 as a key mediator of chemotaxis and inflammation, and the biological consequences thereof. Curcumin 57-65 C-C motif chemokine ligand 2 Homo sapiens 87-92 27743775-7 2017 Animal studies have also revealed that curcumin can attenuate MCP-1 expression and improve a range of inflammatory diseases through multiple molecular targets and mechanisms of action. Curcumin 39-47 C-C motif chemokine ligand 2 Homo sapiens 62-67 27743775-8 2017 There is limited data from human clinical trials showing the decreasing effect of curcumin on MCP-1 concentrations and improvement of the course of inflammatory diseases. Curcumin 82-90 C-C motif chemokine ligand 2 Homo sapiens 94-99 27743775-9 2017 Most of the in vitro and animal studies confirm that curcumin exert its MCP-1-lowering and anti-inflammatory effects by down-regulating the mitogen-activated protein kinase (MAPK) and NF-kappaB signaling pathway. Curcumin 53-61 C-C motif chemokine ligand 2 Homo sapiens 72-77 27743775-10 2017 As yet, there is limited data from human clinical trials showing the effect of curcumin on MCP-1 levels and improvement of the course of inflammatory diseases. Curcumin 79-87 C-C motif chemokine ligand 2 Homo sapiens 91-96 27808345-11 2017 In agreement, mCRP induced upregulation of the TF signalling pathway in mECs with downstream phosphorylation of AKT and activation of the transcription factor ETS1 leading to increased CCL2 release. mcrp 14-18 C-C motif chemokine ligand 2 Homo sapiens 185-189 27921117-10 2017 Blocking the ERK1/2 pathway in ASMSCs with U0126 corrected the abnormal osteogenic differentiation, inhibited MCP1 overexpression, and prevented subsequent monocyte dysfunction. U 0126 43-48 C-C motif chemokine ligand 2 Homo sapiens 110-114 27561918-3 2017 The transported polyphenols were able to downregulate the secretion of pro-inflammatory markers, i.e. IL-8, monocyte chemoattractant protein 1, vascular endothelial growth factor, and intercellular adhesion molecule 1, under normal and tumor necrosis factor alpha induced inflammatory conditions. Polyphenols 16-27 C-C motif chemokine ligand 2 Homo sapiens 108-142 27980102-10 2017 In addition, CCL2 nAb enhanced hepatic NK-cell cytotoxicity and IFNgamma production, which is likely to contribute to the inhibition of tumorigenesis. nab 18-21 C-C motif chemokine ligand 2 Homo sapiens 13-17 27956244-5 2017 Nevertheless DTX-1 was more potent than OA in increasing TNF-alpha and IL-6 as well as their dependent chemokines KC, MCP-1, LIX, MIP-1 alpha, MIP-1 beta and MIP-2. dinophysistoxin 1 13-18 C-C motif chemokine ligand 2 Homo sapiens 118-123 27856463-4 2017 Here we show that KIT D816V promotes expression of the proangiogenic cytokine CCL2 in neoplastic mast cells. d816v 22-27 C-C motif chemokine ligand 2 Homo sapiens 78-82 27856463-5 2017 Correspondingly, the KIT-targeting drug midostaurin and RNA interference-mediated knockdown of KIT reduced expression of CCL2. midostaurin 40-51 C-C motif chemokine ligand 2 Homo sapiens 121-125 29349065-11 2017 Conclusions: The reduction of urinary MCP-1 excretion in the absence of MCP-1 serum concentration may suggest a beneficial effect of omega-3 supplementation on tubular MCP-1 production. Fatty Acids, Omega-3 133-140 C-C motif chemokine ligand 2 Homo sapiens 38-43 28176921-8 2017 RESULTS: Local expressions instead of CX3CL1 and CCL2 in STANR, AF, and NP were significantly higher in the SP group than in M-MP compared with scoliosis painless group. sp 108-110 C-C motif chemokine ligand 2 Homo sapiens 49-53 27751964-5 2017 Among all chemokines, expression levels of three chemokine ligand-receptor systems, i.e., CCL2-CCR2, CCL3-CCR1/5, and CCL4-CCR5, were up-regulated in the SDH of diabetic monkeys. sdh 154-157 C-C motif chemokine ligand 2 Homo sapiens 90-94 29288479-7 2017 After stimulation with LPS, TSA and both agents together CCL2 expression rose by 1.52, 1.62 and 1.8 times in comparison to control cultures respectively. trichostatin A 28-31 C-C motif chemokine ligand 2 Homo sapiens 57-61 28027722-4 2017 Celastrol significantly inhibited poly(I:C)-induced expression of adhesion molecules, such as ICAM-1/VCAM-1, and chemokines, such as CCL2, CXCL8, and CXCL10, in CRT-MG human astroglioma cells. celastrol 0-9 C-C motif chemokine ligand 2 Homo sapiens 133-137 28286770-0 2017 Dexmedetomidine Attenuates Lipopolysaccharide Induced MCP-1 Expression in Primary Astrocyte. Dexmedetomidine 0-15 C-C motif chemokine ligand 2 Homo sapiens 54-59 28286770-4 2017 This study aimed to investigate the potential effects of DEX on the production of MCP-1 in lipopolysaccharide-stimulated astrocytes. Dexmedetomidine 57-60 C-C motif chemokine ligand 2 Homo sapiens 82-87 28286770-10 2017 Administration of DEX significantly inhibited the expression of MCP-1 mRNA (P < 0.001). Dexmedetomidine 18-21 C-C motif chemokine ligand 2 Homo sapiens 64-69 28286770-13 2017 DEX is a potent suppressor of MCP-1 in astrocytes induced with lipopolysaccharide through alpha2A-adrenergic receptors, which potentially explains its beneficial effects in the treatment of delirium by attenuating neuroinflammation. Dexmedetomidine 0-3 C-C motif chemokine ligand 2 Homo sapiens 30-35 28027722-4 2017 Celastrol significantly inhibited poly(I:C)-induced expression of adhesion molecules, such as ICAM-1/VCAM-1, and chemokines, such as CCL2, CXCL8, and CXCL10, in CRT-MG human astroglioma cells. poly 34-38 C-C motif chemokine ligand 2 Homo sapiens 133-137 28027722-4 2017 Celastrol significantly inhibited poly(I:C)-induced expression of adhesion molecules, such as ICAM-1/VCAM-1, and chemokines, such as CCL2, CXCL8, and CXCL10, in CRT-MG human astroglioma cells. Carbon 0-1 C-C motif chemokine ligand 2 Homo sapiens 133-137 26981614-10 2017 CONCLUSIONS: Nine cytokines, including NCAM1, IGFBP6, Lipocalin2, LYVE1, TGFB1, MMP10, EGF, PDGFA and CCL2, might act as potential markers for early prediction of MMI and involve in the progression from NACI to MMI. naci 203-207 C-C motif chemokine ligand 2 Homo sapiens 102-106 27828735-6 2017 Iohexol and Urografin also caused a significant increase in NF-kappaB followed by the release of IL-6 and MCP-1. Iohexol 0-7 C-C motif chemokine ligand 2 Homo sapiens 106-111 27828735-6 2017 Iohexol and Urografin also caused a significant increase in NF-kappaB followed by the release of IL-6 and MCP-1. Diatrizoate Meglumine 12-21 C-C motif chemokine ligand 2 Homo sapiens 106-111 30147247-2 2017 Competitive adsorption between chlorinated benzenes and chlorinated phenols affects the transformation of these precursors and plays a crucial role in the PCDD/F formation in mixed MCP/1,2-DCBz-feed streams. chlorobenzene 31-51 C-C motif chemokine ligand 2 Homo sapiens 181-186 30147247-2 2017 Competitive adsorption between chlorinated benzenes and chlorinated phenols affects the transformation of these precursors and plays a crucial role in the PCDD/F formation in mixed MCP/1,2-DCBz-feed streams. Phenols 68-75 C-C motif chemokine ligand 2 Homo sapiens 181-186 30147247-2 2017 Competitive adsorption between chlorinated benzenes and chlorinated phenols affects the transformation of these precursors and plays a crucial role in the PCDD/F formation in mixed MCP/1,2-DCBz-feed streams. pcdd/f 155-161 C-C motif chemokine ligand 2 Homo sapiens 181-186 30147247-2 2017 Competitive adsorption between chlorinated benzenes and chlorinated phenols affects the transformation of these precursors and plays a crucial role in the PCDD/F formation in mixed MCP/1,2-DCBz-feed streams. 3,4-dichlorocatechol 189-193 C-C motif chemokine ligand 2 Homo sapiens 181-186 27814627-5 2017 High IL-10 (p=0.014), IL-23 (p<0.001), IFN-gamma (p<0.001) and MCP-1 (p=0.002) correlated with high 8-OHdG and high IL-23 (p<0.001), INF-gamma (p<0.001), IP-10 (p=0.023) and MCP-1 (p=0.002) correlated with low leukocyte mtDNA. 8-ohdg 106-112 C-C motif chemokine ligand 2 Homo sapiens 69-74 27814627-5 2017 High IL-10 (p=0.014), IL-23 (p<0.001), IFN-gamma (p<0.001) and MCP-1 (p=0.002) correlated with high 8-OHdG and high IL-23 (p<0.001), INF-gamma (p<0.001), IP-10 (p=0.023) and MCP-1 (p=0.002) correlated with low leukocyte mtDNA. 8-ohdg 106-112 C-C motif chemokine ligand 2 Homo sapiens 186-191 27511707-7 2017 QA decreased lipopolysaccharide-induced secretion of tumour necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1), and it significantly reduced the expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, TNF-alpha and MCP-1. quinovic acid 0-2 C-C motif chemokine ligand 2 Homo sapiens 98-132 27722989-9 2017 Inhibition of TLR4 attenuated the high-glucose-induced expression of MCP-1 mRNA and protein, MyD88 mRNA, nuclear NF-kappaB p65 protein, TGF-beta, fibronectin, and alpha-SMA mRNA and protein. Glucose 39-46 C-C motif chemokine ligand 2 Homo sapiens 69-74 27035356-2 2017 Therefore, we predict that in vascular smooth muscle (VSMCs), MCPIP1 may be induced by MCP-1 and undergo degradation, which can be inhibited by the proteasome inhibitor, MG132. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 170-175 C-C motif chemokine ligand 2 Homo sapiens 87-92 27511707-7 2017 QA decreased lipopolysaccharide-induced secretion of tumour necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1), and it significantly reduced the expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, TNF-alpha and MCP-1. quinovic acid 0-2 C-C motif chemokine ligand 2 Homo sapiens 134-139 27511707-7 2017 QA decreased lipopolysaccharide-induced secretion of tumour necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1), and it significantly reduced the expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, TNF-alpha and MCP-1. quinovic acid 0-2 C-C motif chemokine ligand 2 Homo sapiens 273-278 28326930-9 2017 JWH015 reduced the concentration of major pro-inflammatory factors (IL-6 and MCP-1) and increased the concentration of a major anti-inflammatory factor (TGF-beta) in lipopolysaccharide-stimulated cells. JHW 015 0-6 C-C motif chemokine ligand 2 Homo sapiens 77-82 28472795-10 2017 MCP-1 expression increased after toxins treatment but decreased after Pb treatment. Probenecid 70-72 C-C motif chemokine ligand 2 Homo sapiens 0-5 28472795-11 2017 PCS and IS uptake were mediated by OATs, and OAT blockage could serve as a therapeutic strategy to inhibit MCP-1 expression. 4-cresol sulfate 0-3 C-C motif chemokine ligand 2 Homo sapiens 107-112 28934926-8 2017 RESULTS: DIM significantly (p<0.05) reduced the production and mRNA expression of MCP-1, IL-6, and TNFalpha in a DIM concentration dependent manner, concomitantly increasing the abundance of IRS-1 pY612 and Akt-1/PKB pT308. pt308 220-225 C-C motif chemokine ligand 2 Homo sapiens 85-90 29017158-1 2017 OBJECTIVE: To determine the effect of supplementation with n-3 polyunsaturated fatty acids (PUFAs) on circulatory resistin and monocyte chemoattractant protein 1 (MCP-1) levels in type 2 diabetes mellitus (T2DM) patients. Fatty Acids, Omega-3 59-90 C-C motif chemokine ligand 2 Homo sapiens 127-161 29017158-1 2017 OBJECTIVE: To determine the effect of supplementation with n-3 polyunsaturated fatty acids (PUFAs) on circulatory resistin and monocyte chemoattractant protein 1 (MCP-1) levels in type 2 diabetes mellitus (T2DM) patients. Fatty Acids, Omega-3 59-90 C-C motif chemokine ligand 2 Homo sapiens 163-168 29017158-1 2017 OBJECTIVE: To determine the effect of supplementation with n-3 polyunsaturated fatty acids (PUFAs) on circulatory resistin and monocyte chemoattractant protein 1 (MCP-1) levels in type 2 diabetes mellitus (T2DM) patients. Fatty Acids, Unsaturated 92-97 C-C motif chemokine ligand 2 Homo sapiens 127-161 29017158-1 2017 OBJECTIVE: To determine the effect of supplementation with n-3 polyunsaturated fatty acids (PUFAs) on circulatory resistin and monocyte chemoattractant protein 1 (MCP-1) levels in type 2 diabetes mellitus (T2DM) patients. Fatty Acids, Unsaturated 92-97 C-C motif chemokine ligand 2 Homo sapiens 163-168 29017158-11 2017 CONCLUSIONS: The MCP-1 levels and lipid profile were improved after supplementation with n-3 PUFAs, but resistin serum levels were not changed. Fatty Acids, Omega-3 89-98 C-C motif chemokine ligand 2 Homo sapiens 17-22 28291657-0 2017 Oxidized phospholipids exert a dual effect on bile acid-induced CCL2 expression in pancreatic acini. Phospholipids 9-22 C-C motif chemokine ligand 2 Homo sapiens 64-68 28546852-3 2017 Resveratrol was safe and well tolerated and was associated with significant increases in the numbers of circulating gammadelta T cells and regulatory T cells and resulted in small, yet significant, decreases in the plasma levels of the proinflammatory cytokines TNF-alpha and MCP-1 and a significant increase in the plasma antioxidant activity compared with the corresponding antioxidant baseline activity and with that in four control individuals. Resveratrol 0-11 C-C motif chemokine ligand 2 Homo sapiens 276-281 27819395-3 2017 Here, we describe the mechanisms through which TCA affects human astrocytes, demonstrating: a late apoptotic process, mediated by caspases 9 and 3 activation, involving the Bcl2-Bak-axis; an early and late p38 MAPK activation; an interference with the IL-8 and MCP-1 secretory response. Trichloroacetic Acid 47-50 C-C motif chemokine ligand 2 Homo sapiens 261-266 28785380-6 2017 Ginkgolide B also reduced the levels of platelet endothelial cell adhesion molecule-1, interleukin-6, and monocyte chemotactic protein 1. ginkgolide B 0-12 C-C motif chemokine ligand 2 Homo sapiens 106-136 28291657-0 2017 Oxidized phospholipids exert a dual effect on bile acid-induced CCL2 expression in pancreatic acini. Bile Acids and Salts 46-55 C-C motif chemokine ligand 2 Homo sapiens 64-68 28291657-11 2017 Mediated by PPARgamma, oxPOPC (50 muM) inhibited the CCL2 overexpression found in NaTc-treated acini. oxpopc 23-29 C-C motif chemokine ligand 2 Homo sapiens 53-57 28291657-11 2017 Mediated by PPARgamma, oxPOPC (50 muM) inhibited the CCL2 overexpression found in NaTc-treated acini. natc 82-86 C-C motif chemokine ligand 2 Homo sapiens 53-57 27888616-9 2016 Finally, we reported that curcumin, a powerful natural drug, suppressed the production of EGF and CCL2 in macrophages and cancer cells, respectively, blocking the feedback loop and suppressing the migration and invasion of HNSCC cells. Curcumin 26-34 C-C motif chemokine ligand 2 Homo sapiens 98-102 30263473-2 2016 EGCG significantly decreased the secretion of nitric oxide (NO) and monocyte chemoattractant protein-1 in the coculture of RAW 264.7 macrophages and differentiated 3T3-L1 adipocytes. epigallocatechin gallate 0-4 C-C motif chemokine ligand 2 Homo sapiens 68-102 28030645-6 2016 Depletion of cholesterol by MbetaCD increased MCP-1 secretion as well as the mRNA and protein levels, suggesting perturbation at biosynthesis and secretion. Cholesterol 13-24 C-C motif chemokine ligand 2 Homo sapiens 46-51 28030645-6 2016 Depletion of cholesterol by MbetaCD increased MCP-1 secretion as well as the mRNA and protein levels, suggesting perturbation at biosynthesis and secretion. methyl-beta-cyclodextrin 28-35 C-C motif chemokine ligand 2 Homo sapiens 46-51 28030645-7 2016 Pharmacological inhibition revealed that NF-kappaB, but not MEK, p38 and JNK, was involved in MbetaCD-stimulated MCP-1 biosynthesis and secretion in adipocytes. methyl-beta-cyclodextrin 94-101 C-C motif chemokine ligand 2 Homo sapiens 113-118 28030645-8 2016 Finally, another cholesterol-binding drug, filipin, also induced MCP-1 secretion without altering membrane cholesterol level. Cholesterol 17-28 C-C motif chemokine ligand 2 Homo sapiens 65-70 28030645-10 2016 Thus, the depletion of membrane cholesterol in obese adipocytes may result in dysfunction of lipid rafts, leading to the elevation of proinflammatory signaling and MCP-1 secretion in adipocytes. Cholesterol 32-43 C-C motif chemokine ligand 2 Homo sapiens 164-169 26690313-1 2016 AIMS: Bindarit (BND) is a selective inhibitor of monocyte chemotactic protein-1 (MCP-1/CCL2), which plays an important role in generating intimal hyperplasia. bindarit 6-14 C-C motif chemokine ligand 2 Homo sapiens 49-79 28078047-5 2016 Synthesis of IL-6, MCP-1 and hyaluronan in unstimulated and stimulated with interleukin-1 (100 pg/ml) HPMC was inhibited in the presence of DHMEQ and the effect was proportional to the dose of the drug. hydroxypropylmethylcellulose-lactose matrix 102-106 C-C motif chemokine ligand 2 Homo sapiens 19-24 28078047-5 2016 Synthesis of IL-6, MCP-1 and hyaluronan in unstimulated and stimulated with interleukin-1 (100 pg/ml) HPMC was inhibited in the presence of DHMEQ and the effect was proportional to the dose of the drug. dehydroxymethylepoxyquinomicin 140-145 C-C motif chemokine ligand 2 Homo sapiens 19-24 28078047-6 2016 DHMEQ (10 microg/ml) reduced in unstimulated HPMC synthesis of IL-6 (-55%), MCP-1 (-58%) and hyaluronan (-41%). dehydroxymethylepoxyquinomicin 0-5 C-C motif chemokine ligand 2 Homo sapiens 76-81 27983705-6 2016 Our results indicated an efficient reduction in pro-inflammatory factors (TNFalpha, IL-6, MCP-1, HMGB1) upon culture with riboflavin supplementation (500-1000 nM), accompanied by elevation in anti-inflammatory adiponectin and IL-10. Riboflavin 122-132 C-C motif chemokine ligand 2 Homo sapiens 90-95 29657992-9 2017 Conclusion: SNPs in the FAS/CD95, RB1/LPAR6 and CCL2 genes were found to be associated with nausea among women treated with adjuvant FEC for BC. ammonium ferrous sulfate 24-27 C-C motif chemokine ligand 2 Homo sapiens 48-52 26690313-1 2016 AIMS: Bindarit (BND) is a selective inhibitor of monocyte chemotactic protein-1 (MCP-1/CCL2), which plays an important role in generating intimal hyperplasia. bindarit 6-14 C-C motif chemokine ligand 2 Homo sapiens 81-86 26690313-1 2016 AIMS: Bindarit (BND) is a selective inhibitor of monocyte chemotactic protein-1 (MCP-1/CCL2), which plays an important role in generating intimal hyperplasia. bindarit 6-14 C-C motif chemokine ligand 2 Homo sapiens 87-91 27801570-0 2016 Enrichment of Two Isomeric Heparin Oligosaccharides Exhibiting Different Affinities toward Monocyte Chemoattractant Protein-1. heparin oligosaccharides 27-51 C-C motif chemokine ligand 2 Homo sapiens 91-125 27801570-2 2016 Here we demonstrate chromatographic isolation and purification of two heparin hexasaccharide isomers that interact with the oligomeric chemokine Monocyte Chemoattractant Protein-1 (MCP-1)/CCL2 with different binding affinities. heparin hexasaccharide 70-92 C-C motif chemokine ligand 2 Homo sapiens 145-179 27801570-2 2016 Here we demonstrate chromatographic isolation and purification of two heparin hexasaccharide isomers that interact with the oligomeric chemokine Monocyte Chemoattractant Protein-1 (MCP-1)/CCL2 with different binding affinities. heparin hexasaccharide 70-92 C-C motif chemokine ligand 2 Homo sapiens 181-186 27801570-2 2016 Here we demonstrate chromatographic isolation and purification of two heparin hexasaccharide isomers that interact with the oligomeric chemokine Monocyte Chemoattractant Protein-1 (MCP-1)/CCL2 with different binding affinities. heparin hexasaccharide 70-92 C-C motif chemokine ligand 2 Homo sapiens 188-192 27801570-4 2016 Ion mobility mass spectrometry (IM-MS) showed that the two isolated oligosaccharides have different conformations and both displayed preferential binding for one of the two distinct conformations known for MCP-1 dimers. Oligosaccharides 68-84 C-C motif chemokine ligand 2 Homo sapiens 206-211 27801570-7 2016 The structural difference between the two hexasaccharides was defined as the differential location of a single sulfate at either C-6 of glucosamine or C-2 of uronic acid in the reducing disaccharide, resulting in a 200-fold difference in binding affinity for MCP-1. hexasaccharides 42-57 C-C motif chemokine ligand 2 Homo sapiens 259-264 27801570-7 2016 The structural difference between the two hexasaccharides was defined as the differential location of a single sulfate at either C-6 of glucosamine or C-2 of uronic acid in the reducing disaccharide, resulting in a 200-fold difference in binding affinity for MCP-1. Sulfates 111-118 C-C motif chemokine ligand 2 Homo sapiens 259-264 27801570-7 2016 The structural difference between the two hexasaccharides was defined as the differential location of a single sulfate at either C-6 of glucosamine or C-2 of uronic acid in the reducing disaccharide, resulting in a 200-fold difference in binding affinity for MCP-1. Uronic Acids 158-169 C-C motif chemokine ligand 2 Homo sapiens 259-264 27801570-7 2016 The structural difference between the two hexasaccharides was defined as the differential location of a single sulfate at either C-6 of glucosamine or C-2 of uronic acid in the reducing disaccharide, resulting in a 200-fold difference in binding affinity for MCP-1. Disaccharides 186-198 C-C motif chemokine ligand 2 Homo sapiens 259-264 27558640-4 2016 In vitro, treatment with ramalin produced significantly less inflammatory chemokines and cytokines, including TARC, MCP-1, RANTES, and IL-8 in TNF-alpha-stimulated HaCaT cells. Ramalin 25-32 C-C motif chemokine ligand 2 Homo sapiens 116-121 27677742-8 2016 Lenalidomide and trabectedin prevent TAM recruitment mainly through CCL2 blockade. Lenalidomide 0-12 C-C motif chemokine ligand 2 Homo sapiens 68-72 27677742-8 2016 Lenalidomide and trabectedin prevent TAM recruitment mainly through CCL2 blockade. Trabectedin 17-28 C-C motif chemokine ligand 2 Homo sapiens 68-72 27677742-8 2016 Lenalidomide and trabectedin prevent TAM recruitment mainly through CCL2 blockade. tam 37-40 C-C motif chemokine ligand 2 Homo sapiens 68-72 27520709-7 2016 Fructose-exposed pups have cardiomegaly, oxidation, and depletion in Se heart deposits, a decrease in selenoproteins" expression and in the p-AMPK/AMPKt energy ratio; an increase in NF-kB p65 expression, and a decrease of thyroid hormones and MCP-1. Fructose 0-8 C-C motif chemokine ligand 2 Homo sapiens 243-248 27889107-6 2016 However, supplementing adipocytes with an equal combination of malvidin plus peonidin followed by LPS treatment decreased the mRNA levels of interleukin (IL)-6, IL-1beta, IL-8, monocyte chemoattractant protein-1, toll-like receptor-2, tumor necrosis factor alpha, cyclooxygenase-2, and interferon gamma-induced protein-10. peonidin 77-85 C-C motif chemokine ligand 2 Homo sapiens 177-262 28774105-0 2016 Strontium-Substituted Bioceramics Particles: A New Way to Modulate MCP-1 and Gro-alpha Production by Human Primary Osteoblastic Cells. Strontium 0-9 C-C motif chemokine ligand 2 Homo sapiens 67-72 28774105-7 2016 Importantly, the current work determines the down-regulating effect of strontium-substituted CaP on MCP-1 and Gro-alpha production. Strontium 71-80 C-C motif chemokine ligand 2 Homo sapiens 100-105 27904436-6 2016 RESULTS: We found that metformin reduced the levels of IL-6 in blood and MCP-1 in urine, but increased IL-10 levels in blood of patients with type 2 diabetes. Metformin 23-32 C-C motif chemokine ligand 2 Homo sapiens 73-78 27933092-5 2016 Interestingly, the decreases in the CXCL7 and CCL2 levels were both positively correlated with the decreases in the serum low-density lipoprotein-cholesterol (LDL-C), high-sensitivity C-reactive protein (hsCRP) and interleukin-1beta (IL-1beta) levels after anthocyanin supplementation for 24 weeks. Anthocyanins 257-268 C-C motif chemokine ligand 2 Homo sapiens 46-50 27904436-8 2016 Furthermore, compared to individual drug treatment, metformin significantly reduced the levels of serum IL-6 and TNF-alpha, as well as urine MCP-1. Metformin 52-61 C-C motif chemokine ligand 2 Homo sapiens 141-146 27904436-10 2016 Metformin (1.5 g) treatment reduced the urinary levels of MCP-1 as compared with dose of 1.0 g in patients with type 2 diabetes. Metformin 0-9 C-C motif chemokine ligand 2 Homo sapiens 58-63 27591243-13 2016 14,15-EET treatment resulted in a significant reduction in IL-6, IL-8, and MCP-1 secretion, and increased accumulation of Nrf2 and expression of HO-1. 14,15-epoxy-5,8,11-eicosatrienoic acid 0-9 C-C motif chemokine ligand 2 Homo sapiens 75-80 27281349-5 2016 Budesonide suppressed secreted chemokines IL-8 and CCL2 (MCP-1) within 4 hours, reaching a 90% decrease at 12 hours, which was fully reversed 72 hours after removal of the steroid. Budesonide 0-10 C-C motif chemokine ligand 2 Homo sapiens 51-55 27281349-5 2016 Budesonide suppressed secreted chemokines IL-8 and CCL2 (MCP-1) within 4 hours, reaching a 90% decrease at 12 hours, which was fully reversed 72 hours after removal of the steroid. Budesonide 0-10 C-C motif chemokine ligand 2 Homo sapiens 57-62 28955982-7 2016 PPARbeta/delta activation induced expression of several anti-inflammatory genes in a dose-dependent manner, and GW501516 inhibited Mcp1 promoter-driven luciferase in a BCL6-dependent manner. GW 501516 112-120 C-C motif chemokine ligand 2 Homo sapiens 131-135 27749218-5 2016 RESULTS: Patients with pSS had higher prevalence of carotid atherosclerosis (13% vs. 2%, p<0.05) and higher serum levels of calprotectin, tumour necrosis factor receptor 2 (TNF-R2), hepatocyte growth factor (HGF), and monocyte chemoattractant protein-1 (MCP-1) than controls. pss 23-26 C-C motif chemokine ligand 2 Homo sapiens 221-255 27890374-4 2016 RESULTS: The serum levels of MCP-1, TNF-alpha and IL-8 from MAP group, MSAP group and SAP group at day 1 of admission to hospital all significantly increased. msap 71-75 C-C motif chemokine ligand 2 Homo sapiens 29-34 27890374-7 2016 In MSAP group and SAP group, the serum concentrations of MCP-1, TNF-alpha and IL-8 were the highest at day 1, which were significantly higher than the detection levels at day 4 and 7. msap 3-7 C-C motif chemokine ligand 2 Homo sapiens 57-62 27890374-8 2016 At each detecting timing, the serum concentrations of MCP-1, TNF-alpha and IL-8 from MSAP group and SAP group were all higher than those of MAP group and MSAP group, respectively. msap 85-89 C-C motif chemokine ligand 2 Homo sapiens 54-59 28164676-11 2016 In addition, CCL2 levels were positively correlated with inflammation markers TNF-alpha, IL-6, and VAS scores. vas 99-102 C-C motif chemokine ligand 2 Homo sapiens 13-17 27749218-5 2016 RESULTS: Patients with pSS had higher prevalence of carotid atherosclerosis (13% vs. 2%, p<0.05) and higher serum levels of calprotectin, tumour necrosis factor receptor 2 (TNF-R2), hepatocyte growth factor (HGF), and monocyte chemoattractant protein-1 (MCP-1) than controls. pss 23-26 C-C motif chemokine ligand 2 Homo sapiens 257-262 27770720-3 2016 Five types of flavonoids: isoliquiritigenin, chrysin, 3",4"-dihydroxy-4-methoxydalbergione, 4-methoxydalbergion, and cearoin, markedly inhibited inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS mRNA and LPS-induced mRNA expression of TNFalpha and CCL2. Cearoin 117-124 C-C motif chemokine ligand 2 Homo sapiens 295-299 27770720-3 2016 Five types of flavonoids: isoliquiritigenin, chrysin, 3",4"-dihydroxy-4-methoxydalbergione, 4-methoxydalbergion, and cearoin, markedly inhibited inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS mRNA and LPS-induced mRNA expression of TNFalpha and CCL2. Flavonoids 14-24 C-C motif chemokine ligand 2 Homo sapiens 295-299 27770720-4 2016 Their inhibitory effects on LPS-induced inflammatory responses correlated with the intensities of these flavonoids to suppress the LPS-induced activation of nuclear factor kappaB (NF-kappaB), an essential transcription factor for the mRNA expression of iNOS, TNFalpha, and CCL2. Flavonoids 104-114 C-C motif chemokine ligand 2 Homo sapiens 273-277 27770720-3 2016 Five types of flavonoids: isoliquiritigenin, chrysin, 3",4"-dihydroxy-4-methoxydalbergione, 4-methoxydalbergion, and cearoin, markedly inhibited inflammatory responses including LPS-induced NO production by suppressing the expression of iNOS mRNA and LPS-induced mRNA expression of TNFalpha and CCL2. isoliquiritigenin 26-43 C-C motif chemokine ligand 2 Homo sapiens 295-299 27157387-12 2016 The stimulatory effect of HG-MacCM on MCP-1 expression in adipocytes was partially inhibited when MDMs were treated with sc-514 (IKKbeta inhibitor). SC 514 121-127 C-C motif chemokine ligand 2 Homo sapiens 38-43 27739445-6 2016 Using ex vivo human CRC explants, quininib significantly reduced the secretions of IL-6, IL-8, VEGF, ENA-78, GRO-alpha, TNF, IL-1beta and MCP-1 ex vivo (all values p < 0.01). quininib 34-42 C-C motif chemokine ligand 2 Homo sapiens 138-143 27523388-6 2016 The antigen-specific release of each cytokine, IFN-gamma, IP-10, and MCP-1, was significantly higher in the TB groups than in either the non-tuberculous pulmonary disease group (p < 0.001) or the healthy control group (p < 0.001). Terbium 108-110 C-C motif chemokine ligand 2 Homo sapiens 69-74 27342654-12 2016 After treatment, serum hs-CRP, MCP-1, and TNF-alpha in the TGP group decreased more than the losartan group. tgp 59-62 C-C motif chemokine ligand 2 Homo sapiens 31-36 27567684-8 2016 Furthermore, kinsenoside suppressed the protein and gene expression of NF-kappaB, and reduced the release of intercellular adhesion molecule-1 (ICAM-1) and human monocyte chemoattractant protein-1 (MCP-1) in a dose-dependent manner remarkably. 3-glucopyranosyloxybutanolide 13-24 C-C motif chemokine ligand 2 Homo sapiens 162-196 27295129-8 2016 We also identified 3 drugs, methotrexate, quercetin, and mimosine, which repressed the activated cell cycle genes, ARID5B, STK17B, and CCL2, in HeLa cells with minimal side-effects. Methotrexate 28-40 C-C motif chemokine ligand 2 Homo sapiens 135-139 27295129-8 2016 We also identified 3 drugs, methotrexate, quercetin, and mimosine, which repressed the activated cell cycle genes, ARID5B, STK17B, and CCL2, in HeLa cells with minimal side-effects. Quercetin 42-51 C-C motif chemokine ligand 2 Homo sapiens 135-139 27295129-8 2016 We also identified 3 drugs, methotrexate, quercetin, and mimosine, which repressed the activated cell cycle genes, ARID5B, STK17B, and CCL2, in HeLa cells with minimal side-effects. Mimosine 57-65 C-C motif chemokine ligand 2 Homo sapiens 135-139 27567684-8 2016 Furthermore, kinsenoside suppressed the protein and gene expression of NF-kappaB, and reduced the release of intercellular adhesion molecule-1 (ICAM-1) and human monocyte chemoattractant protein-1 (MCP-1) in a dose-dependent manner remarkably. 3-glucopyranosyloxybutanolide 13-24 C-C motif chemokine ligand 2 Homo sapiens 198-203 27424158-6 2016 Compared to metformin, exenatide was more effective in reducing MCP-1 levels. Exenatide 23-32 C-C motif chemokine ligand 2 Homo sapiens 64-69 26609908-11 2016 (4) Urinary MCP-1 and TGF-1 concentrations were positively correlated with serum creatinine and decreased in the SG group. Creatinine 81-91 C-C motif chemokine ligand 2 Homo sapiens 12-17 26609908-12 2016 CONCLUSION: Low-dosage steroid therapy reversed or delayed the renal failure progression in severe chronic AAN patients, which may be associated with the suppression of MCP-1 and TGF-beta1 activities. Steroids 23-30 C-C motif chemokine ligand 2 Homo sapiens 169-174 27424158-13 2016 Exenatide was more effective than metformin in reducing MCP-1 expression and JNK activity. Exenatide 0-9 C-C motif chemokine ligand 2 Homo sapiens 56-61 27576203-3 2016 Transcription and secretion of CCL2, CCL3, and CCL4 chemokines enhanced by 27OHChol were significantly attenuated by diclofenac in a concentration dependent manner. 27ohchol 75-83 C-C motif chemokine ligand 2 Homo sapiens 31-35 27424158-13 2016 Exenatide was more effective than metformin in reducing MCP-1 expression and JNK activity. Metformin 34-43 C-C motif chemokine ligand 2 Homo sapiens 56-61 27667443-4 2016 Upon treatment with acetate SCFA or FFAR2- and FFAR3-specific synthetic agonists, human monocytes displayed elevated p38 phosphorylation and attenuated C5, CCL1, CCL2, GM-CSF, IL-1alpha, IL-1beta and ICAM-1 inflammatory cytokine expression. Acetates 20-27 C-C motif chemokine ligand 2 Homo sapiens 162-166 27685462-6 2016 RESULTS: The levels of IL-1ra, IL-2, IL-13, IL-15, IFN-gamma, IP-10 and MCP-1 in background corrected TB antigen stimulated supernatants (TBAg-Nil) significantly distinguished both active TB and LTBI QFT high groups from the QFT negative controls (p<=0.004). tbag 138-142 C-C motif chemokine ligand 2 Homo sapiens 72-77 27576203-3 2016 Transcription and secretion of CCL2, CCL3, and CCL4 chemokines enhanced by 27OHChol were significantly attenuated by diclofenac in a concentration dependent manner. Diclofenac 117-127 C-C motif chemokine ligand 2 Homo sapiens 31-35 27576203-5 2016 Superproduction of CCL2 and monocytic cell migration induced by 27OHChol plus LPS were significantly attenuated by diclofenac. 27ohchol 64-72 C-C motif chemokine ligand 2 Homo sapiens 19-23 27576203-5 2016 Superproduction of CCL2 and monocytic cell migration induced by 27OHChol plus LPS were significantly attenuated by diclofenac. Diclofenac 115-125 C-C motif chemokine ligand 2 Homo sapiens 19-23 27392713-8 2016 Furthermore, luciferase-reporter analysis indicated that MCP-1 promoter activity was predominantly suppressed by dihydrotestosterone (DHT)-AR interactions through functional canonical nuclear factor-kappa B (NF-kappaB) sites, whereas non-canonical NF-kappaB site containing important flanking sequences exhibited minor contributions to DHT-AR transcriptional repression. Dihydrotestosterone 336-339 C-C motif chemokine ligand 2 Homo sapiens 57-62 27666890-3 2016 Testosterone 10 mumol/L was added into indirect co-culture for 24 h. ELISA was used to testing IL-6, MCP-1 concentrations in supernatant. Testosterone 0-12 C-C motif chemokine ligand 2 Homo sapiens 101-106 27666890-6 2016 Results: Testosterone enhanced inflammatory cytokines (IL-6, MCP-1) production in indirect co-culture of 3T3-L1 adipocytes and RAW264.7 macrophages, promoted the activation of ERK1/2 and nuclear factor kappa B p65, and inhibited glucose uptake in adipocytes. Testosterone 9-21 C-C motif chemokine ligand 2 Homo sapiens 61-66 27579511-1 2016 Rate coefficients k1-k3 have been measured for Cl atom reactions with CF2 CF2, CFCl CFCl, and CCl2 CF2 relative to k4 for CF2 CF-CF CF2 at 293 +- 2 K. k4 was remeasured relative to Cl + ethane. cl + ethane 181-192 C-C motif chemokine ligand 2 Homo sapiens 94-98 27458015-0 2016 CC-Chemokine Ligand 2 (CCL2) Suppresses High Density Lipoprotein (HDL) Internalization and Cholesterol Efflux via CC-Chemokine Receptor 2 (CCR2) Induction and p42/44 Mitogen-activated Protein Kinase (MAPK) Activation in Human Endothelial Cells. Cholesterol 91-102 C-C motif chemokine ligand 2 Homo sapiens 0-21 27458015-0 2016 CC-Chemokine Ligand 2 (CCL2) Suppresses High Density Lipoprotein (HDL) Internalization and Cholesterol Efflux via CC-Chemokine Receptor 2 (CCR2) Induction and p42/44 Mitogen-activated Protein Kinase (MAPK) Activation in Human Endothelial Cells. Cholesterol 91-102 C-C motif chemokine ligand 2 Homo sapiens 23-27 27458015-6 2016 Furthermore, CCL2 inhibited [(3)H]cholesterol efflux to HDL/apoA1 in ECs. Tritium 30-33 C-C motif chemokine ligand 2 Homo sapiens 13-17 27458015-6 2016 Furthermore, CCL2 inhibited [(3)H]cholesterol efflux to HDL/apoA1 in ECs. Cholesterol 34-45 C-C motif chemokine ligand 2 Homo sapiens 13-17 27458015-7 2016 We further found that CCL2 induced CC-chemokine receptor 2 (CCR2) expression and siRNA-CCR2 reversed CCL2 suppression on HDL binding, association, internalization, and on cholesterol efflux in ECs. Cholesterol 171-182 C-C motif chemokine ligand 2 Homo sapiens 101-105 27458015-10 2016 CCL2 suppressed HDL internalization and cholesterol efflux via CCR2 induction and p42/44 MAPK activation in ECs. Cholesterol 40-51 C-C motif chemokine ligand 2 Homo sapiens 0-4 27392713-8 2016 Furthermore, luciferase-reporter analysis indicated that MCP-1 promoter activity was predominantly suppressed by dihydrotestosterone (DHT)-AR interactions through functional canonical nuclear factor-kappa B (NF-kappaB) sites, whereas non-canonical NF-kappaB site containing important flanking sequences exhibited minor contributions to DHT-AR transcriptional repression. Dihydrotestosterone 113-132 C-C motif chemokine ligand 2 Homo sapiens 57-62 27392713-8 2016 Furthermore, luciferase-reporter analysis indicated that MCP-1 promoter activity was predominantly suppressed by dihydrotestosterone (DHT)-AR interactions through functional canonical nuclear factor-kappa B (NF-kappaB) sites, whereas non-canonical NF-kappaB site containing important flanking sequences exhibited minor contributions to DHT-AR transcriptional repression. Dihydrotestosterone 134-137 C-C motif chemokine ligand 2 Homo sapiens 57-62 27060359-5 2016 UA markedly reduced the expressions of ICAM-1 (intercellular adhesion molecule 1) and MCP-1 (monocyte chemotactic protein 1) and further attenuated THP-1 (human acute monocytic leukemia cell line) cell adhesion. 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one 0-2 C-C motif chemokine ligand 2 Homo sapiens 93-123 27309675-12 2016 Our data strengthen the importance of CCL2 on ET-1, AngII- and TGFbeta-induced mesangial cell dysfunction, adding new insights into the cellular mechanisms responsible of bindarit protective effects in human MC dysfunction. bindarit 171-179 C-C motif chemokine ligand 2 Homo sapiens 38-42 27394658-7 2016 Furthermore, treatment the MEK1/2 kinase inhibitor PD98059 blocked increases in MCP-1 secretion and augmented Cry1Ac-induced ICOS-L upregulation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 51-58 C-C motif chemokine ligand 2 Homo sapiens 80-85 26641773-4 2016 In this study, we demonstrate that treatment of HL-60 cells with allopurinol significantly increased the mRNA expression levels of interleukin-8, monocyte chemotactic protein-1 and tumor necrosis factor alpha in a time- and concentration-dependent manner. Allopurinol 65-76 C-C motif chemokine ligand 2 Homo sapiens 146-208 27060359-5 2016 UA markedly reduced the expressions of ICAM-1 (intercellular adhesion molecule 1) and MCP-1 (monocyte chemotactic protein 1) and further attenuated THP-1 (human acute monocytic leukemia cell line) cell adhesion. 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one 0-2 C-C motif chemokine ligand 2 Homo sapiens 86-91 27548845-5 2016 CCL2/CXCL10 are reported in relation to urine creatinine (ng/mmol). Creatinine 46-56 C-C motif chemokine ligand 2 Homo sapiens 0-4 27548845-6 2016 RESULTS: Fifty-two patients (52/185, 28%) reached the primary outcome at a median 6.0 years, and their urinary CCL2:Cr was significantly higher compared with patients with stable allograft function (median [interquartile range], 38.6 ng/mmol [19.7-72.5] vs 25.9 ng/mmol [16.1-45.8], P = 0.009). Chromium 116-118 C-C motif chemokine ligand 2 Homo sapiens 111-115 27548845-7 2016 Low urinary CCL2:Cr (<=70.0 ng/mmol) was associated with 88% 5-year event-free survival compared with 50% with high urinary CCL2:Cr (P < 0.0001). Chromium 17-19 C-C motif chemokine ligand 2 Homo sapiens 12-16 27548845-8 2016 In a multivariate Cox-regression model, the only independent predictors of the primary outcome were high CCL2:Cr (hazard ratio [HR], 2.86; 95% confidence interval [95% CI], 1.33-5.73) and CXCL10:Cr (HR, 2.35; 95% CI, 1.23-4.88; both P = 0.009). Chromium 110-112 C-C motif chemokine ligand 2 Homo sapiens 105-109 27548845-9 2016 Urinary CCL2:Cr/CXCL10:Cr area under the curves were 0.62 (P = 0.001)/0.63 (P = 0.03), respectively. Chromium 13-15 C-C motif chemokine ligand 2 Homo sapiens 8-12 27548845-11 2016 CONCLUSIONS: This study confirms that urinary CCL2:Cr is an independent predictor of long-term allograft outcomes. Chromium 51-53 C-C motif chemokine ligand 2 Homo sapiens 46-50 27548845-12 2016 Urinary CCL2:Cr/CXCL10:Cr alone have similar prognostic performance, but when both are elevated, this suggests a worse prognosis. Chromium 13-15 C-C motif chemokine ligand 2 Homo sapiens 8-12 27513734-7 2016 Furthermore, stimulation with 1,25(OH)2D reduced mRNA expression levels and/or protein levels of IL-8, TNF-alpha and MCP-1 in CSE-treated THP-1 macrophages. 1,25(oh)2d 30-40 C-C motif chemokine ligand 2 Homo sapiens 117-122 27189318-8 2016 C statistic for traditional predictors of eGFR decline was 0.70, which improved significantly to 0.74 with monocyte chemotactic protein-1-to-creatinine ratio. Creatinine 141-151 C-C motif chemokine ligand 2 Homo sapiens 107-137 27189318-9 2016 CONCLUSIONS: Urinary monocyte chemotactic protein-1-to-creatinine ratio concentrations were strongly associated with sustained renal decline in patients with type 2 diabetes with preserved renal function. Creatinine 55-65 C-C motif chemokine ligand 2 Homo sapiens 21-51 27189318-5 2016 RESULTS: Baseline and 24-month levels of monocyte chemotactic protein-1-to-creatinine ratio levels were higher for cases versus controls. Creatinine 75-85 C-C motif chemokine ligand 2 Homo sapiens 41-71 27189318-6 2016 The highest quartile of baseline monocyte chemotactic protein-1-to-creatinine ratio had fivefold greater odds, and each log increment had 2.27-fold higher odds for outcome (odds ratio, 5.27; 95% confidence interval, 2.19 to 12.71 and odds ratio, 2.27; 95% confidence interval, 1.44 to 3.58, respectively). Creatinine 67-77 C-C motif chemokine ligand 2 Homo sapiens 33-63 27486749-3 2016 This work was completed by an analysis of the effects of cyclosporine A (CsA), dexamethasone (Dex) and doxycycline (Dox) on HO-induced CCL2 and NFAT5 induction. Doxycycline 116-119 C-C motif chemokine ligand 2 Homo sapiens 135-139 27486749-0 2016 In Vitro Inhibition of NFAT5-Mediated Induction of CCL2 in Hyperosmotic Conditions by Cyclosporine and Dexamethasone on Human HeLa-Modified Conjunctiva-Derived Cells. Cyclosporine 86-98 C-C motif chemokine ligand 2 Homo sapiens 51-55 27259980-8 2016 In a model of macrophage-myeloma cell crosstalk, versikine induced components of "T-cell inflammation," including IRF8-dependent type I interferon transcriptional signatures and T-cell chemoattractant CCL2. versikine 49-58 C-C motif chemokine ligand 2 Homo sapiens 201-205 27486749-0 2016 In Vitro Inhibition of NFAT5-Mediated Induction of CCL2 in Hyperosmotic Conditions by Cyclosporine and Dexamethasone on Human HeLa-Modified Conjunctiva-Derived Cells. Dexamethasone 103-116 C-C motif chemokine ligand 2 Homo sapiens 51-55 27486749-3 2016 This work was completed by an analysis of the effects of cyclosporine A (CsA), dexamethasone (Dex) and doxycycline (Dox) on HO-induced CCL2 and NFAT5 induction. Cyclosporine 73-76 C-C motif chemokine ligand 2 Homo sapiens 135-139 27486749-3 2016 This work was completed by an analysis of the effects of cyclosporine A (CsA), dexamethasone (Dex) and doxycycline (Dox) on HO-induced CCL2 and NFAT5 induction. Dexamethasone 79-92 C-C motif chemokine ligand 2 Homo sapiens 135-139 27486749-3 2016 This work was completed by an analysis of the effects of cyclosporine A (CsA), dexamethasone (Dex) and doxycycline (Dox) on HO-induced CCL2 and NFAT5 induction. Dexamethasone 94-97 C-C motif chemokine ligand 2 Homo sapiens 135-139 27486749-3 2016 This work was completed by an analysis of the effects of cyclosporine A (CsA), dexamethasone (Dex) and doxycycline (Dox) on HO-induced CCL2 and NFAT5 induction. Doxycycline 103-114 C-C motif chemokine ligand 2 Homo sapiens 135-139 27486749-9 2016 p38 MAPK (p38), c-Jun NH2-terminal kinase (JNK) and NFkB inhibitors, CsA and Dex induced a partial inhibition of HO-induced CCL2, while Dox and extracellular signal-regulated kinase (ERK) inhibitor did not. Cyclosporine 69-72 C-C motif chemokine ligand 2 Homo sapiens 124-128 27486749-9 2016 p38 MAPK (p38), c-Jun NH2-terminal kinase (JNK) and NFkB inhibitors, CsA and Dex induced a partial inhibition of HO-induced CCL2, while Dox and extracellular signal-regulated kinase (ERK) inhibitor did not. Dexamethasone 77-80 C-C motif chemokine ligand 2 Homo sapiens 124-128 27486749-9 2016 p38 MAPK (p38), c-Jun NH2-terminal kinase (JNK) and NFkB inhibitors, CsA and Dex induced a partial inhibition of HO-induced CCL2, while Dox and extracellular signal-regulated kinase (ERK) inhibitor did not. Holmium 113-115 C-C motif chemokine ligand 2 Homo sapiens 124-128 27470399-6 2016 Within-group analysis revealed significant reductions in serum concentrations of TNF-alpha, IL-6, TGF-beta and MCP-1 following curcumin supplementation (p<0.001). Curcumin 127-135 C-C motif chemokine ligand 2 Homo sapiens 111-116 27470399-8 2016 Between-group comparison suggested significantly greater reductions in serum concentrations of TNF-alpha, IL-6, TGF-beta and MCP-1 in the curcumin versus placebo group (p<0.001). Curcumin 138-146 C-C motif chemokine ligand 2 Homo sapiens 125-130 27339628-5 2016 CCL2 rs4586 showed a significant correlation with OS in a recessive model in a univariate analysis, as well as a multivariate analysis. Osmium 50-52 C-C motif chemokine ligand 2 Homo sapiens 0-4 27253488-6 2016 Within 24h, butyrate significantly decreased the levels of chemokines CCL2 and CCL5 in HL-60 and U937 cells, and decreased CCL5 in THP-1 leukemia cells. Butyrates 12-20 C-C motif chemokine ligand 2 Homo sapiens 70-74 27253488-7 2016 Differential effects were observed in treatments with valproic acid for CCL2 and CCL5 indicating butyrate-specificity. Valproic Acid 54-67 C-C motif chemokine ligand 2 Homo sapiens 72-76 26562135-8 2016 MCP-1 correlated significantly with SRT, dIS/OS, and dELM. Osmium 45-47 C-C motif chemokine ligand 2 Homo sapiens 0-5 28955928-4 2016 Recent studies have demonstrated that cobalt ions from metal-on-metal joints also activate human TLR4, increasing cellular secretion of inflammatory chemokines including interleukin-8 (IL-8, CXCL8) and CCL2. Cobalt 38-44 C-C motif chemokine ligand 2 Homo sapiens 202-206 28955928-4 2016 Recent studies have demonstrated that cobalt ions from metal-on-metal joints also activate human TLR4, increasing cellular secretion of inflammatory chemokines including interleukin-8 (IL-8, CXCL8) and CCL2. Metals 55-60 C-C motif chemokine ligand 2 Homo sapiens 202-206 28955928-9 2016 Cobalt ions significantly increased release of CCL2 and IL-6 by MonoMac 6 cells (P<0.001). Cobalt 0-6 C-C motif chemokine ligand 2 Homo sapiens 47-51 26384705-12 2016 Macrophage infiltration and increase of monocyte chemotactic protein-1 in kidneys were induced by iohexol, and it was aggravated with autophagy inhibition. Iohexol 98-105 C-C motif chemokine ligand 2 Homo sapiens 40-70 27263035-7 2016 Correlation of MCP-1 with both ADMA and SDMA levels at 6 hours was associated with both NIHSS worsening and poststroke infections, respectively; sCD40L and SDMA correlation at 6 hours was also associated with NIHSS worsening. N,N-dimethylarginine 31-35 C-C motif chemokine ligand 2 Homo sapiens 15-20 27263035-7 2016 Correlation of MCP-1 with both ADMA and SDMA levels at 6 hours was associated with both NIHSS worsening and poststroke infections, respectively; sCD40L and SDMA correlation at 6 hours was also associated with NIHSS worsening. symmetric dimethylarginine 40-44 C-C motif chemokine ligand 2 Homo sapiens 15-20 28164647-3 2016 RESULTS: We observed a significant increase of TNFalpha and CCL2 mRNA expression in leukocytes placed in EDTA anticoagulant compared to leukocytes collected with citrate or heparin (p <= 0.5). Edetic Acid 105-109 C-C motif chemokine ligand 2 Homo sapiens 60-64 28164647-4 2016 Compared to blood cells influenced by one of the three anticoagulant agents present in vacuum tubes, cells from transfusion bags affected by CPDA displayed significantly lower levels of CCL2 and MYC mRNA, whereas levels of IL-10 and TNFalpha mRNA were much higher (p <= 0.5). CPDA 141-145 C-C motif chemokine ligand 2 Homo sapiens 186-190 27655482-8 2016 When MCs were stimulated with SP (2 muM), there was a statistically significant beta-hex release as well as release of TNF, VEGF and MCP-1. TFF2 protein, human 30-32 C-C motif chemokine ligand 2 Homo sapiens 133-138 26667361-2 2016 Tissue factor (TF), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant protein 1 (MCP-1) may play critical roles in the process of CTEPH thrombosis and pulmonary vascular remodeling. cteph 175-180 C-C motif chemokine ligand 2 Homo sapiens 90-124 26667361-2 2016 Tissue factor (TF), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant protein 1 (MCP-1) may play critical roles in the process of CTEPH thrombosis and pulmonary vascular remodeling. cteph 175-180 C-C motif chemokine ligand 2 Homo sapiens 126-131 26667361-9 2016 In CTEPH patients, the expression of CRP, TNF-alpha, and MCP-1 was significantly higher than that in controls (P < 0.05). cteph 3-8 C-C motif chemokine ligand 2 Homo sapiens 57-62 26667361-11 2016 In CTEPH patients, levels of CRP, MCP-1, and TNF-alpha significantly correlated with the level of TF antigen in plasma. cteph 3-8 C-C motif chemokine ligand 2 Homo sapiens 34-39 27031327-4 2016 We show that both the polymers and nanoparticles possess high binding affinity for the chemokine monocyte chemoattractant protein-1 (MCP-1) in monomeric and dimeric form. Polymers 22-30 C-C motif chemokine ligand 2 Homo sapiens 133-138 27038284-1 2016 Silver nanoparticle immobilized mesoporous cross-linked polyacrylic acid (Ag-MCP-1) has been synthesized via aqueous-phase polymerization of acrylic acid followed by the surface immobilization with silver nanoparticles. Silver 0-6 C-C motif chemokine ligand 2 Homo sapiens 77-82 27038284-1 2016 Silver nanoparticle immobilized mesoporous cross-linked polyacrylic acid (Ag-MCP-1) has been synthesized via aqueous-phase polymerization of acrylic acid followed by the surface immobilization with silver nanoparticles. carbopol 940 56-72 C-C motif chemokine ligand 2 Homo sapiens 77-82 27038284-1 2016 Silver nanoparticle immobilized mesoporous cross-linked polyacrylic acid (Ag-MCP-1) has been synthesized via aqueous-phase polymerization of acrylic acid followed by the surface immobilization with silver nanoparticles. acrylic acid 60-72 C-C motif chemokine ligand 2 Homo sapiens 77-82 27038284-1 2016 Silver nanoparticle immobilized mesoporous cross-linked polyacrylic acid (Ag-MCP-1) has been synthesized via aqueous-phase polymerization of acrylic acid followed by the surface immobilization with silver nanoparticles. Silver 198-204 C-C motif chemokine ligand 2 Homo sapiens 77-82 27038284-4 2016 The Ag-MCP-1 nanocomposite can be used as an efficient heterogeneous catalyst in the reductive coupling of nitrobenzenes and alcohols using glycerol as hydrogen source. Nitrobenzenes 107-120 C-C motif chemokine ligand 2 Homo sapiens 7-12 27038284-4 2016 The Ag-MCP-1 nanocomposite can be used as an efficient heterogeneous catalyst in the reductive coupling of nitrobenzenes and alcohols using glycerol as hydrogen source. Alcohols 125-133 C-C motif chemokine ligand 2 Homo sapiens 7-12 27038284-4 2016 The Ag-MCP-1 nanocomposite can be used as an efficient heterogeneous catalyst in the reductive coupling of nitrobenzenes and alcohols using glycerol as hydrogen source. Glycerol 140-148 C-C motif chemokine ligand 2 Homo sapiens 7-12 27038284-4 2016 The Ag-MCP-1 nanocomposite can be used as an efficient heterogeneous catalyst in the reductive coupling of nitrobenzenes and alcohols using glycerol as hydrogen source. Hydrogen 152-160 C-C motif chemokine ligand 2 Homo sapiens 7-12 27363897-2 2016 In addition, MCP1-induced cortactin tyrosine phosphorylation, p21Cip1 degradation and HASMC proliferation are dependent on Fyn activation. Tyrosine 36-44 C-C motif chemokine ligand 2 Homo sapiens 13-17 27363897-3 2016 Upstream to Fyn, MCP1 stimulated C-C chemokine receptor type 2 (CCR2) and Gi/o and inhibition of either one of these molecules using their specific antagonists or inhibitors attenuated MCP1-induced cortactin tyrosine phosphorylation, p21Cip1 degradation and HASMC proliferation. Tyrosine 208-216 C-C motif chemokine ligand 2 Homo sapiens 17-21 27363897-3 2016 Upstream to Fyn, MCP1 stimulated C-C chemokine receptor type 2 (CCR2) and Gi/o and inhibition of either one of these molecules using their specific antagonists or inhibitors attenuated MCP1-induced cortactin tyrosine phosphorylation, p21Cip1 degradation and HASMC proliferation. Tyrosine 208-216 C-C motif chemokine ligand 2 Homo sapiens 185-189 27170049-10 2016 Orbital fibroblasts expressed HRH1 and loratadine and SC-514 both blocked histamine-induced IL-6, IL-8 and CCL2 production by orbital fibroblasts. SC 514 54-60 C-C motif chemokine ligand 2 Homo sapiens 107-111 27199127-8 2016 Sitagliptin treatment improved cardiac function and perfusion, reduced macrophage infiltration, and diminished the levels of inflammatory biomarkers including TNF-alpha, IL-1beta, and CCL2. Sitagliptin Phosphate 0-11 C-C motif chemokine ligand 2 Homo sapiens 184-188 27170049-10 2016 Orbital fibroblasts expressed HRH1 and loratadine and SC-514 both blocked histamine-induced IL-6, IL-8 and CCL2 production by orbital fibroblasts. Loratadine 39-49 C-C motif chemokine ligand 2 Homo sapiens 107-111 27170049-9 2016 Histamine stimulated the production of IL-6, IL-8 and CCL2 by orbital fibroblasts, while it had no effect on the production of CCL5, CCL7, CXCL10, CXCL11 and hyaluronan. Histamine 0-9 C-C motif chemokine ligand 2 Homo sapiens 54-58 27170049-10 2016 Orbital fibroblasts expressed HRH1 and loratadine and SC-514 both blocked histamine-induced IL-6, IL-8 and CCL2 production by orbital fibroblasts. Histamine 74-83 C-C motif chemokine ligand 2 Homo sapiens 107-111 27058904-0 2016 Changes in plasma chemokine C-C motif ligand 2 levels during treatment with eicosapentaenoic acid predict outcome in patients undergoing surgery for colorectal cancer liver metastasis. Eicosapentaenoic Acid 76-97 C-C motif chemokine ligand 2 Homo sapiens 18-46 27438970-0 2016 p-cresol but not p-cresyl sulfate stimulate MCP-1 production via NF-kappaB p65 in human vascular smooth muscle cells. 4-cresol 0-8 C-C motif chemokine ligand 2 Homo sapiens 44-49 27438970-10 2016 When VSMC were treated with the NF-kappaB p65 inhibitor plus PCu and PCm, there was a significant decrease in MCP-1 production (p < 0.005). vsmc 5-9 C-C motif chemokine ligand 2 Homo sapiens 110-115 27438970-13 2016 Our results suggest that PC mediates MCP-1 production in VSMC, probably through NF-kappaB p65 pathway, although we hypothesize that PCS acts through a different subunit pathway since NF-kappaB p65 inhibitor was not able to inhibit MCP-1 production. 4-cresol 25-27 C-C motif chemokine ligand 2 Homo sapiens 37-42 27438970-13 2016 Our results suggest that PC mediates MCP-1 production in VSMC, probably through NF-kappaB p65 pathway, although we hypothesize that PCS acts through a different subunit pathway since NF-kappaB p65 inhibitor was not able to inhibit MCP-1 production. vsmc 57-61 C-C motif chemokine ligand 2 Homo sapiens 37-42 27131284-9 2016 However, dabigatran at low concentrations (3-300nM) increased significantly the expression levels of CXCL1, CXCL2, IL-8, ELAM-1, MCP-1, and tissue factor. Dabigatran 9-19 C-C motif chemokine ligand 2 Homo sapiens 129-134 26924089-23 2016 Pharmacologic inhibitors of AKT and P38 inhibited secretion of CCL2 and CCL17 by these PBNs. pbns 87-91 C-C motif chemokine ligand 2 Homo sapiens 63-67 27058904-2 2016 We tested the hypothesis that EPA reduces expression of chemokine C-C motif ligand 2 (CCL2), a pro-inflammatory chemokine with known roles in metastasis.We measured CCL2 in clinical samples from a randomized trial of EPA in patients undergoing liver surgery for CRC liver metastasis (LM) and preclinical models. Eicosapentaenoic Acid 30-33 C-C motif chemokine ligand 2 Homo sapiens 56-84 27058904-2 2016 We tested the hypothesis that EPA reduces expression of chemokine C-C motif ligand 2 (CCL2), a pro-inflammatory chemokine with known roles in metastasis.We measured CCL2 in clinical samples from a randomized trial of EPA in patients undergoing liver surgery for CRC liver metastasis (LM) and preclinical models. Eicosapentaenoic Acid 30-33 C-C motif chemokine ligand 2 Homo sapiens 86-90 27058904-2 2016 We tested the hypothesis that EPA reduces expression of chemokine C-C motif ligand 2 (CCL2), a pro-inflammatory chemokine with known roles in metastasis.We measured CCL2 in clinical samples from a randomized trial of EPA in patients undergoing liver surgery for CRC liver metastasis (LM) and preclinical models. Eicosapentaenoic Acid 30-33 C-C motif chemokine ligand 2 Homo sapiens 165-169 27058904-2 2016 We tested the hypothesis that EPA reduces expression of chemokine C-C motif ligand 2 (CCL2), a pro-inflammatory chemokine with known roles in metastasis.We measured CCL2 in clinical samples from a randomized trial of EPA in patients undergoing liver surgery for CRC liver metastasis (LM) and preclinical models. Eicosapentaenoic Acid 217-220 C-C motif chemokine ligand 2 Homo sapiens 86-90 27058904-3 2016 Genome-wide transcriptional profiling of tumors from EPA-treated patients was performed.EPA decreased CCL2 synthesis by CRC cells in a dose-dependent manner. Eicosapentaenoic Acid 53-56 C-C motif chemokine ligand 2 Homo sapiens 102-106 27058904-6 2016 However, EPA treatment was associated with decreased plasma CCL2 levels compared with controls (P=0.04). Eicosapentaenoic Acid 9-12 C-C motif chemokine ligand 2 Homo sapiens 60-64 27058904-7 2016 Reduction in plasma CCL2 following EPA treatment predicted improved disease-free survival (HR 0.32; P=0.003). Eicosapentaenoic Acid 35-38 C-C motif chemokine ligand 2 Homo sapiens 20-24 27058904-8 2016 Lack of "CCL2 response" was associated with a specific CRCLM gene expression signature.In conclusion, reduction in plasma CCL2 in patients with CRCLM treated with EPA predicts better clinical outcome and a specific tumor gene expression profile. Eicosapentaenoic Acid 163-166 C-C motif chemokine ligand 2 Homo sapiens 9-13 27058904-8 2016 Lack of "CCL2 response" was associated with a specific CRCLM gene expression signature.In conclusion, reduction in plasma CCL2 in patients with CRCLM treated with EPA predicts better clinical outcome and a specific tumor gene expression profile. Eicosapentaenoic Acid 163-166 C-C motif chemokine ligand 2 Homo sapiens 122-126 27058904-9 2016 Further work is needed to validate CCL2 as a therapeutic response biomarker for omega-3 fatty acid treatment of CRC patients. Fatty Acids, Omega-3 80-98 C-C motif chemokine ligand 2 Homo sapiens 35-39 27098798-8 2016 PKA inhibitor H-89 markedly reduced the oxLDL-induced MCP-1 expression, but no further decrease was observed when H-89 was used in combination with L-4F (50 mug/ml) (P > 0.05). N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide 14-18 C-C motif chemokine ligand 2 Homo sapiens 54-59 27152519-9 2016 Further, patients with successful ARBE treatment featured enhanced levels of Th17-cell specific cytokine IL-22 and immunoregulatory cytokine IL-10 as well as reduced serum levels of TNF-alpha and MCP-1, but enhanced levels of IL-17A, in contrast to patients that did not reach remission after ARBE treatment. arbe 34-38 C-C motif chemokine ligand 2 Homo sapiens 196-201 26910885-10 2016 Here it was discovered that the ubiquinol status significantly correlated to the concentration of the inflammation marker monocyte chemotactic protein 1. ubiquinol 32-41 C-C motif chemokine ligand 2 Homo sapiens 122-152 27125366-9 2016 Change in CIMTBIF correlated with log values of baseline absolute count of non-classical monocytes (r = 0.37, p = 0.020), and with MCP-1 (r = 0.42, p = 0.0024) and TNF-alpha (r = 0.30, p = 0.036) levels. cimtbif 10-17 C-C motif chemokine ligand 2 Homo sapiens 131-136 26790757-7 2016 We found that exposure to cortisol induced transient upregulation of monocyte mRNA for CCR2, the receptor for monocyte chemotactic protein-1 (MCP-1/CCL2) as well as for the chemokine receptor CX3CR1. Hydrocortisone 26-34 C-C motif chemokine ligand 2 Homo sapiens 110-140 26790757-7 2016 We found that exposure to cortisol induced transient upregulation of monocyte mRNA for CCR2, the receptor for monocyte chemotactic protein-1 (MCP-1/CCL2) as well as for the chemokine receptor CX3CR1. Hydrocortisone 26-34 C-C motif chemokine ligand 2 Homo sapiens 142-147 26790757-7 2016 We found that exposure to cortisol induced transient upregulation of monocyte mRNA for CCR2, the receptor for monocyte chemotactic protein-1 (MCP-1/CCL2) as well as for the chemokine receptor CX3CR1. Hydrocortisone 26-34 C-C motif chemokine ligand 2 Homo sapiens 148-152 27125366-10 2016 In multivariable linear regression, only non-classical monocytes and MCP-1 predicted the change in CIMTBIF, independent of Framingham Risk Score and baseline CIMTBIF. cimtbif 99-106 C-C motif chemokine ligand 2 Homo sapiens 69-74 27125366-13 2016 CONCLUSIONS: Our findings highlight the role of non-classical monocytes and MCP-1 in the progression of CIMTBIF in HIV-infected individuals on stable ART independent of traditional cardio-metabolic risk factors. cimtbif 104-111 C-C motif chemokine ligand 2 Homo sapiens 76-81 27145432-3 2016 Resveratrol (50 muM or 5-50 muM) inhibited the production of interleukin-10 and monocyte chemoattractant protein-1 in M2 macrophages, whereas it promoted that of transforming growth factor-beta1. Resveratrol 0-11 C-C motif chemokine ligand 2 Homo sapiens 80-114 26949104-9 2016 This suggests that 1,25(OH)2D3 inhibits ROS, MCP-1, ICAM-1, and adherence of monocytes mediated by the upregulation of GCLC and GSH. Calcitriol 19-30 C-C motif chemokine ligand 2 Homo sapiens 45-50 26014148-0 2016 Role of MCP-1 in alcohol-induced aggressiveness of colorectal cancer cells. Alcohols 17-24 C-C motif chemokine ligand 2 Homo sapiens 8-13 26014148-9 2016 Alcohol increased the expression of MCP-1 and its receptor CCR2 at both protein and mRNA levels. Alcohols 0-7 C-C motif chemokine ligand 2 Homo sapiens 36-41 26014148-10 2016 The pattern of alcohol-induced alterations in MCP-1 expression was consistent with its effect on migration/invasion; HCT116 cells displayed the highest up-regulation of MCP-1/CCR2 in response to alcohol exposure. Alcohols 15-22 C-C motif chemokine ligand 2 Homo sapiens 46-51 26014148-10 2016 The pattern of alcohol-induced alterations in MCP-1 expression was consistent with its effect on migration/invasion; HCT116 cells displayed the highest up-regulation of MCP-1/CCR2 in response to alcohol exposure. Alcohols 15-22 C-C motif chemokine ligand 2 Homo sapiens 169-174 26014148-10 2016 The pattern of alcohol-induced alterations in MCP-1 expression was consistent with its effect on migration/invasion; HCT116 cells displayed the highest up-regulation of MCP-1/CCR2 in response to alcohol exposure. Alcohols 195-202 C-C motif chemokine ligand 2 Homo sapiens 46-51 26014148-10 2016 The pattern of alcohol-induced alterations in MCP-1 expression was consistent with its effect on migration/invasion; HCT116 cells displayed the highest up-regulation of MCP-1/CCR2 in response to alcohol exposure. Alcohols 195-202 C-C motif chemokine ligand 2 Homo sapiens 169-174 26014148-13 2016 Alcohol stimulated the activity of MCP-1 gene promoter in a beta-catenin-dependent manner. Alcohols 0-7 C-C motif chemokine ligand 2 Homo sapiens 35-40 26014148-14 2016 Furthermore, knock-down of MCP-1/CCR2 or beta-catenin was sufficient to inhibit alcohol-induced cell migration/invasion. Alcohols 80-87 C-C motif chemokine ligand 2 Homo sapiens 27-32 26014148-15 2016 Together, these results suggested that alcohol may promote the metastasis of CRC through modulating GSK3beta/beta-catenin/MCP-1 pathway. Alcohols 39-46 C-C motif chemokine ligand 2 Homo sapiens 122-127 26732386-6 2016 We showed that CTS significantly suppressed TNF-alpha-induced increased endothelial permeability, monocyte adhesion, sICAM-1, sVCAM-1 and MCP-1, and restored nitric oxide production. cryptotanshinone 15-18 C-C motif chemokine ligand 2 Homo sapiens 138-143 26746853-9 2016 Pravastatin inhibited ANG-induced MCP-1 production. Pravastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 34-39 26976796-5 2016 Aleglitazar, at concentrations as low as 10nmol/L, providing the half-maximal transcriptional activation of both PPARalpha and PPARgamma, reduced the stimulated expression of several pro-inflammatory mediators including interleukin (IL)-6, the chemokine CXC-L10, and monocyte chemoattractant protein (MCP)-1. aleglitazar 0-11 C-C motif chemokine ligand 2 Homo sapiens 267-307 26976796-6 2016 Correspondingly, media from adipocytes treated with aleglitazar reduced monocyte migration, consistent with suppression of MCP-1 secretion. aleglitazar 52-63 C-C motif chemokine ligand 2 Homo sapiens 123-128 26746853-2 2016 METHODS: MCP-1 production in human umbilical vein endothelial cells (HUVECs) under treatments with ANG, AT1 and angiotensin type 2 (AT2) receptor blockers and pravastatin was measured by ELISA. Pravastatin 159-170 C-C motif chemokine ligand 2 Homo sapiens 9-14 26746853-10 2016 CONCLUSIONS: Our results support that ANG-induced MCP-1 production in HUVECs is mediated by AT2 instead AT1 receptor activation, which in turn activates NF-kappaB involving reactive oxygen species produced by the NADPH oxidase complex. Reactive Oxygen Species 173-196 C-C motif chemokine ligand 2 Homo sapiens 50-55 27069498-7 2016 Hydroxycinnamic acid derivatives also reduce the expression of the potent proinflammatory adipokines tumor necrosis factor-alpha (TNFalpha), monocyte chemoattractant protein-1 (MCP-1), and plasminogen activator inhibitor type-1 (PAI-1), and they increase the secretion of an anti-inflammatory agent adiponectin from adipocytes. Coumaric Acids 0-20 C-C motif chemokine ligand 2 Homo sapiens 141-175 27104513-8 2016 Gallic acid and chlorogenic acid could suppress the release of pro-inflammatory cytokine IL-6 and chemokine CCL7 and CXCL8, respectively, in IL-31- and IL-33-treated eosinophils-dermal fibroblasts co-culture; while berberine could suppress the release of IL-6, CXCL8, CCL2 and CCL7 in the eosinophil culture and eosinophils-dermal fibroblasts co-culture (all p < 0.05). Gallic Acid 0-11 C-C motif chemokine ligand 2 Homo sapiens 268-272 27104513-8 2016 Gallic acid and chlorogenic acid could suppress the release of pro-inflammatory cytokine IL-6 and chemokine CCL7 and CXCL8, respectively, in IL-31- and IL-33-treated eosinophils-dermal fibroblasts co-culture; while berberine could suppress the release of IL-6, CXCL8, CCL2 and CCL7 in the eosinophil culture and eosinophils-dermal fibroblasts co-culture (all p < 0.05). Chlorogenic Acid 16-32 C-C motif chemokine ligand 2 Homo sapiens 268-272 27124181-9 2016 In addition, PGE2 inhibited the expression of inflammatory genes (i.e. IL-6 and MCP-1) in WAT explants as well as in adipocytes challenged with LPS. Dinoprostone 13-17 C-C motif chemokine ligand 2 Homo sapiens 80-85 27175087-0 2016 Toward a noncytotoxic glioblastoma therapy: blocking MCP-1 with the MTZ Regimen. mtz 68-71 C-C motif chemokine ligand 2 Homo sapiens 53-58 27175087-7 2016 Three noncytotoxic drugs, an antibiotic - minocycline, an antihypertensive drug - telmisartan, and a bisphosphonate - zoledronic acid, have ancillary attributes of MCP-1 synthesis inhibition and could be re-purposed, singly or in combination, to inhibit or reverse MLC-mediated immunosuppression, angiogenesis, and other growth-enhancing aspects. Minocycline 42-53 C-C motif chemokine ligand 2 Homo sapiens 164-169 27175087-7 2016 Three noncytotoxic drugs, an antibiotic - minocycline, an antihypertensive drug - telmisartan, and a bisphosphonate - zoledronic acid, have ancillary attributes of MCP-1 synthesis inhibition and could be re-purposed, singly or in combination, to inhibit or reverse MLC-mediated immunosuppression, angiogenesis, and other growth-enhancing aspects. Telmisartan 82-93 C-C motif chemokine ligand 2 Homo sapiens 164-169 27175087-7 2016 Three noncytotoxic drugs, an antibiotic - minocycline, an antihypertensive drug - telmisartan, and a bisphosphonate - zoledronic acid, have ancillary attributes of MCP-1 synthesis inhibition and could be re-purposed, singly or in combination, to inhibit or reverse MLC-mediated immunosuppression, angiogenesis, and other growth-enhancing aspects. Zoledronic Acid 101-133 C-C motif chemokine ligand 2 Homo sapiens 164-169 27069498-7 2016 Hydroxycinnamic acid derivatives also reduce the expression of the potent proinflammatory adipokines tumor necrosis factor-alpha (TNFalpha), monocyte chemoattractant protein-1 (MCP-1), and plasminogen activator inhibitor type-1 (PAI-1), and they increase the secretion of an anti-inflammatory agent adiponectin from adipocytes. Coumaric Acids 0-20 C-C motif chemokine ligand 2 Homo sapiens 177-182 27044314-3 2016 The present study investigates the basal effects of EPA, DHA and a mixture EPA + DHA on the expression of 10 genes (AKT1, MAPK, NFKB, TNFA, IL1Beta, MCP1, ALOX5, PTGS2, MGST1 and NOS2) related to inflammation in unstimulated cultured THP1 macrophages. Docosahexaenoic Acids 81-84 C-C motif chemokine ligand 2 Homo sapiens 149-153 27044314-7 2016 Treatment with 50 muM, 10 muM EPA, 50 muM DHA and EPA + DHA decreased expression levels of cytokines genes IL1Beta and MCP1. Eicosapentaenoic Acid 30-33 C-C motif chemokine ligand 2 Homo sapiens 119-123 27044314-7 2016 Treatment with 50 muM, 10 muM EPA, 50 muM DHA and EPA + DHA decreased expression levels of cytokines genes IL1Beta and MCP1. Eicosapentaenoic Acid 50-53 C-C motif chemokine ligand 2 Homo sapiens 119-123 27044314-7 2016 Treatment with 50 muM, 10 muM EPA, 50 muM DHA and EPA + DHA decreased expression levels of cytokines genes IL1Beta and MCP1. Docosahexaenoic Acids 56-59 C-C motif chemokine ligand 2 Homo sapiens 119-123 27044314-7 2016 Treatment with 50 muM, 10 muM EPA, 50 muM DHA and EPA + DHA decreased expression levels of cytokines genes IL1Beta and MCP1. Docosahexaenoic Acids 42-45 C-C motif chemokine ligand 2 Homo sapiens 119-123 26701099-4 2016 Strikingly, evoxine also inhibits hypercapnic suppression of interleukin-6 and the chemokine CCL2 expression in human THP-1 macrophages. EVOXINE 12-19 C-C motif chemokine ligand 2 Homo sapiens 93-97 26832326-7 2016 In addition, (-)-linalool inhibited microglial migration induced by monocyte-chemoattractant protein-1 (MCP-1), a chemokine released by OGD/R. linalool 13-25 C-C motif chemokine ligand 2 Homo sapiens 68-102 26832326-7 2016 In addition, (-)-linalool inhibited microglial migration induced by monocyte-chemoattractant protein-1 (MCP-1), a chemokine released by OGD/R. linalool 13-25 C-C motif chemokine ligand 2 Homo sapiens 104-109 26593599-4 2016 Our data demonstrated that LCB significantly reduced the expression and secretion of IL-6, MCP-1 and leptin, as well as suppressed the overexpression of PAI-1 induced by H2O2. CHEMBL4090226 27-30 C-C motif chemokine ligand 2 Homo sapiens 91-96 27069129-0 2016 Unfractionated Heparin Selectively Modulates the Expression of CXCL8, CCL2 and CCL5 in Endometrial Carcinoma Cells. Heparin 15-22 C-C motif chemokine ligand 2 Homo sapiens 70-74 27069129-5 2016 UFH attenuated the secretion of CXCL8 and CCL2, and enhanced that of CCL5. Heparin 0-3 C-C motif chemokine ligand 2 Homo sapiens 42-46 27069129-7 2016 CONCLUSION: UFH has selective modulating effects on the secretion of CXCL8, CCL2 and CCL5 in different endometrial adenocarcinoma cell lines. Heparin 12-15 C-C motif chemokine ligand 2 Homo sapiens 76-80 27363047-8 2016 We conclude the importance of the detection of MCP-1 expression at the start of therapy as a factor for assessing the likelihood of HCV genotype 4 patients to achieving a sustained virological response to treatment with IFN-a2 in combination with ribavirin. Ribavirin 247-256 C-C motif chemokine ligand 2 Homo sapiens 47-52 26673018-5 2016 Mean CCL2 was 512.9 pg/mL (range 220-917) and positively correlated with triglycerides (r=0.45; p=0.04) and TNF-alpha (r=0.57; p=0.007) and marginally negatively correlated with fruit/vegetable intake (r=-0.42, p=0.06) and omega-3 fatty acids (r=-0.41, p=0.07). Triglycerides 73-86 C-C motif chemokine ligand 2 Homo sapiens 5-9 26673018-5 2016 Mean CCL2 was 512.9 pg/mL (range 220-917) and positively correlated with triglycerides (r=0.45; p=0.04) and TNF-alpha (r=0.57; p=0.007) and marginally negatively correlated with fruit/vegetable intake (r=-0.42, p=0.06) and omega-3 fatty acids (r=-0.41, p=0.07). Fatty Acids, Omega-3 223-242 C-C motif chemokine ligand 2 Homo sapiens 5-9 26573462-4 2016 RESULTS: We found that monocyte chemoattractant protein-1 (MCP-1) was secreted as a dominant component of the SASP during expansion of UCB-MSCs and reinforced senescence via its cognate receptor chemokine (c-c motif) receptor 2 (CCR2) by activating the ROS-p38-MAPK-p53/p21 signaling cascade in both an autocrine and paracrine manner. ros 253-256 C-C motif chemokine ligand 2 Homo sapiens 23-57 26868135-9 2016 In the supernatants obtained after cell incubation with serum from sulodexide treated patients, the increase in concentrations of IL-6, MCP-1 and ICAM-1 was significantly less than the control. glucuronyl glucosamine glycan sulfate 67-77 C-C motif chemokine ligand 2 Homo sapiens 136-141 26811545-9 2016 Concordantly, the ERK inhibitor U0126 significantly decreased IL1B-induced IL6, CXCL8, CCL2 and PTGS2 mRNA abundance; IL6, CXCL8, CCL2 and PGF2 alpha release; and NF-kappaB activation. U 0126 32-37 C-C motif chemokine ligand 2 Homo sapiens 87-91 26811545-9 2016 Concordantly, the ERK inhibitor U0126 significantly decreased IL1B-induced IL6, CXCL8, CCL2 and PTGS2 mRNA abundance; IL6, CXCL8, CCL2 and PGF2 alpha release; and NF-kappaB activation. U 0126 32-37 C-C motif chemokine ligand 2 Homo sapiens 130-134 26630427-11 2016 In addition, animals treated with hydrogel plus steroid showed significant reduction in the number of infiltrating macrophages at the sciatic nerve and reduced expression of the neuroinflammatory chemokine monocyte chemoattractant protein-1 (P < 0.05). Steroids 48-55 C-C motif chemokine ligand 2 Homo sapiens 206-240 26573462-4 2016 RESULTS: We found that monocyte chemoattractant protein-1 (MCP-1) was secreted as a dominant component of the SASP during expansion of UCB-MSCs and reinforced senescence via its cognate receptor chemokine (c-c motif) receptor 2 (CCR2) by activating the ROS-p38-MAPK-p53/p21 signaling cascade in both an autocrine and paracrine manner. ros 253-256 C-C motif chemokine ligand 2 Homo sapiens 59-64 27064875-5 2016 Meta-analysis by vasculitis type revealed an association between the GG+GA genotype of the MCP-1 -2518 A/G polymorphism and Behcet"s disease (BD; OR = 1.349, 95% CI = 1.013-1.796, p = 0.040). Gallium 72-74 C-C motif chemokine ligand 2 Homo sapiens 91-96 26689461-0 2016 Silencing TNFalpha with lipidoid nanoparticles downregulates both TNFalpha and MCP-1 in an in vitro co-culture model of diabetic foot ulcers. lipidoid 24-32 C-C motif chemokine ligand 2 Homo sapiens 79-84 26739492-6 2016 In support, cultured adipocytes demonstrated IH-induced elevations of NADPH oxidase 4, phosphorylation of Erk, NF-kappaBp65, and inducible NOS (iNOS) and increased expression of IL-6 and MCP-1. Ile-His 45-47 C-C motif chemokine ligand 2 Homo sapiens 187-192 26872986-6 2016 Moreover, ambroxol significantly alleviated LPS-induced the influx of inflammatory cells and the extracellular signal-regulated kinase 1/2 (Erk 1/2) expression in lung tissues, and inhibited increases in the mRNA expression of the pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha, CCL-2 (monocyte chemotactic protein-1), KC (keratinocyte cell protein) and interleukin (IL)-1beta in lung tissues. Ambroxol 10-18 C-C motif chemokine ligand 2 Homo sapiens 293-298 26872986-6 2016 Moreover, ambroxol significantly alleviated LPS-induced the influx of inflammatory cells and the extracellular signal-regulated kinase 1/2 (Erk 1/2) expression in lung tissues, and inhibited increases in the mRNA expression of the pro-inflammatory cytokines tumor necrosis factor (TNF)-alpha, CCL-2 (monocyte chemotactic protein-1), KC (keratinocyte cell protein) and interleukin (IL)-1beta in lung tissues. Ambroxol 10-18 C-C motif chemokine ligand 2 Homo sapiens 300-330 29931877-10 2016 CONCLUSIONS: Rosuvastatin may attenuate MCP-1/CCR2 through PPARbeta upstream pathway. Rosuvastatin Calcium 13-25 C-C motif chemokine ligand 2 Homo sapiens 40-45 26963617-12 2016 In the SHR-CRP transgenic strain, we found that metformin treatment decreased circulating levels of inflammatory response marker IL-6, TNFalpha and MCP-1 while levels of human CRP remained unchanged. Metformin 48-57 C-C motif chemokine ligand 2 Homo sapiens 148-153 26689461-9 2016 In co-culture experiments, a single lipidoid nanoparticle dose of 100nM siTNFalpha downregulated TNFalpha and MCP-1 by 64% and 32%, respectively. lipidoid 36-44 C-C motif chemokine ligand 2 Homo sapiens 110-115 26689461-13 2016 We show that siRNA-loaded lipidoid nanoparticles silence the overexpression of tumor necrosis factor alpha (TNFalpha) in inflammatory macrophages which leads to a subsequent downregulation of fibroblast-produced macrophage chemotactant protein-1 (MCP-1). lipidoid 26-34 C-C motif chemokine ligand 2 Homo sapiens 212-245 26689461-13 2016 We show that siRNA-loaded lipidoid nanoparticles silence the overexpression of tumor necrosis factor alpha (TNFalpha) in inflammatory macrophages which leads to a subsequent downregulation of fibroblast-produced macrophage chemotactant protein-1 (MCP-1). lipidoid 26-34 C-C motif chemokine ligand 2 Homo sapiens 247-252 26247921-8 2016 Furthermore, the binding of p65 and cAMP response element binding protein (CREB) binding protein (CBP) or p300 decreased and NF-kappaB related genes which were inhibitors of NF-kappaB alpha (IkappaBalpha), A20, B cell lymphoma protein 2 (Bcl-2), and monocyte chemoattractant protein-1 (MCP-1) were low in cells transfected with Sec6 siRNAs in response to TNF-alpha stimulation. Cyclic AMP 36-40 C-C motif chemokine ligand 2 Homo sapiens 250-284 26802601-9 2016 The results of our study suggest an association between the CCL2 gene rs1024611 G allele and PTDM in patients treated with tacrolimus or cyclosporine. Tacrolimus 123-133 C-C motif chemokine ligand 2 Homo sapiens 60-64 26802601-9 2016 The results of our study suggest an association between the CCL2 gene rs1024611 G allele and PTDM in patients treated with tacrolimus or cyclosporine. Cyclosporine 137-149 C-C motif chemokine ligand 2 Homo sapiens 60-64 26556868-7 2016 Interruption of the newly identified ERbeta/CCL2/CCR2/EMT/MMP9 pathway via either ERbeta-siRNA, ERbeta antagonist PHTPP, or CCR2 antagonist can effectively reverse the mast cell-enhanced BCa cells invasion. PHTPP 114-119 C-C motif chemokine ligand 2 Homo sapiens 44-48 26908203-0 2016 Induction of IL-8(CXCL8) and MCP-1(CCL2) with oxidative stress and its inhibition with N-acetyl cysteine (NAC) in cell culture model using HK-2 cell. Acetylcysteine 106-109 C-C motif chemokine ligand 2 Homo sapiens 35-39 26908203-9 2016 Exposure to hydrogen peroxide induced a significant increase in the activity of the antioxidant enzyme glutathione peroxidase and the levels of the chemokines Interleukin-8 (IL-8; CXCL8) and MCP-1 (CCL2). Hydrogen Peroxide 12-29 C-C motif chemokine ligand 2 Homo sapiens 191-196 26908203-9 2016 Exposure to hydrogen peroxide induced a significant increase in the activity of the antioxidant enzyme glutathione peroxidase and the levels of the chemokines Interleukin-8 (IL-8; CXCL8) and MCP-1 (CCL2). Hydrogen Peroxide 12-29 C-C motif chemokine ligand 2 Homo sapiens 198-202 26908203-11 2016 The cytokine Interleukin-1beta (IL-1beta) at 1 ng/ml significantly potentiated the expression of both IL-8 (CXCL8) and MCP-1 (CCL2) which showed synergistic response in the presence of hydrogen peroxide. Hydrogen Peroxide 185-202 C-C motif chemokine ligand 2 Homo sapiens 119-124 26908203-11 2016 The cytokine Interleukin-1beta (IL-1beta) at 1 ng/ml significantly potentiated the expression of both IL-8 (CXCL8) and MCP-1 (CCL2) which showed synergistic response in the presence of hydrogen peroxide. Hydrogen Peroxide 185-202 C-C motif chemokine ligand 2 Homo sapiens 126-130 26908203-12 2016 Pre-incubation of the cells with the anti-oxidant N-acetyl cysteine (NAC) strongly suppressed the induction of both IL-8 and MCP-1 when stimulated with hydrogen peroxide and IL-1beta. Acetylcysteine 50-67 C-C motif chemokine ligand 2 Homo sapiens 125-130 26908203-12 2016 Pre-incubation of the cells with the anti-oxidant N-acetyl cysteine (NAC) strongly suppressed the induction of both IL-8 and MCP-1 when stimulated with hydrogen peroxide and IL-1beta. Acetylcysteine 69-72 C-C motif chemokine ligand 2 Homo sapiens 125-130 26908203-12 2016 Pre-incubation of the cells with the anti-oxidant N-acetyl cysteine (NAC) strongly suppressed the induction of both IL-8 and MCP-1 when stimulated with hydrogen peroxide and IL-1beta. Hydrogen Peroxide 152-169 C-C motif chemokine ligand 2 Homo sapiens 125-130 26860701-9 2016 TCDD treatment also increased LX-2 cell proliferation, expression of alpha-smooth muscle actin, and production of monocyte chemoattractant protein-1 (MCP-1), all of which are characteristics of activated HSCs. Polychlorinated Dibenzodioxins 0-4 C-C motif chemokine ligand 2 Homo sapiens 114-148 26860701-9 2016 TCDD treatment also increased LX-2 cell proliferation, expression of alpha-smooth muscle actin, and production of monocyte chemoattractant protein-1 (MCP-1), all of which are characteristics of activated HSCs. Polychlorinated Dibenzodioxins 0-4 C-C motif chemokine ligand 2 Homo sapiens 150-155 26901838-6 2016 Daidzein significantly decreased chemokine (C-C motif) ligand 2 (Ccl2, known in humans as monocyte chemo-attractant protein 1 (MCP1)) and interleukin 6 (Il6) mRNA levels induced by co-culture. daidzein 0-8 C-C motif chemokine ligand 2 Homo sapiens 33-63 26901838-6 2016 Daidzein significantly decreased chemokine (C-C motif) ligand 2 (Ccl2, known in humans as monocyte chemo-attractant protein 1 (MCP1)) and interleukin 6 (Il6) mRNA levels induced by co-culture. daidzein 0-8 C-C motif chemokine ligand 2 Homo sapiens 65-69 26901838-6 2016 Daidzein significantly decreased chemokine (C-C motif) ligand 2 (Ccl2, known in humans as monocyte chemo-attractant protein 1 (MCP1)) and interleukin 6 (Il6) mRNA levels induced by co-culture. daidzein 0-8 C-C motif chemokine ligand 2 Homo sapiens 90-125 26901838-6 2016 Daidzein significantly decreased chemokine (C-C motif) ligand 2 (Ccl2, known in humans as monocyte chemo-attractant protein 1 (MCP1)) and interleukin 6 (Il6) mRNA levels induced by co-culture. daidzein 0-8 C-C motif chemokine ligand 2 Homo sapiens 127-131 26901838-8 2016 Daidzein also decreased Ccl2 and Il6 mRNA levels in RAW264 macrophages stimulated with palmitate or conditioned medium (CM) from hypertrophied 3T3-L1 adipocytes. daidzein 0-8 C-C motif chemokine ligand 2 Homo sapiens 24-28 26924930-4 2016 In present study, agmatine attenuated the cell death and the expression of pro-inflammatory cytokines such as IL-6, TNF-alpha and CCL2 in high glucose in vitro conditions. Glucose 143-150 C-C motif chemokine ligand 2 Homo sapiens 130-134 26867220-0 2016 Non-Classical Monocytes and Monocyte Chemoattractant Protein-1 (MCP-1) Correlate with Coronary Artery Calcium Progression in Chronically HIV-1 Infected Adults on Stable Antiretroviral Therapy. Calcium 102-109 C-C motif chemokine ligand 2 Homo sapiens 64-69 26721307-6 2016 In general, EtOH decreased secretion of IP-10, IL-6, eotaxin, GCSF, and MCP-1. Ethanol 12-16 C-C motif chemokine ligand 2 Homo sapiens 72-77 26748475-7 2016 PGC-1beta inhibited PA induced TNFalpha, MCP-1, and IL-1beta mRNA and protein expressions. Palmitic Acid 20-22 C-C motif chemokine ligand 2 Homo sapiens 41-46 26695864-10 2016 Linagliptin abated DPP-4 activity by greater than 50%, significantly increased active glucagon-like peptide-1 and stromal cell-derived factor-1alpha, and reduced monocyte chemotactic protein-1, CCL22, and IL-12. Linagliptin 0-11 C-C motif chemokine ligand 2 Homo sapiens 162-192 26648448-0 2016 N-methyl-N-nitro-N"-nitrosoguanidine induces the expression of CCR2 in human gastric epithelial cells promoting CCL2-mediated migration. Methylnitronitrosoguanidine 0-36 C-C motif chemokine ligand 2 Homo sapiens 112-116 26788115-6 2016 DHA alone attenuated the secretion of pro-inflammatory adipokines such as chemerin, interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1/CCL2), whereas AC suppressed only the latter two. Docosahexaenoic Acids 0-3 C-C motif chemokine ligand 2 Homo sapiens 109-143 26684239-0 2016 Overcoming melanoma resistance to vemurafenib by targeting CCL2-induced miR-34a, miR-100 and miR-125b. Vemurafenib 34-45 C-C motif chemokine ligand 2 Homo sapiens 59-63 26684239-0 2016 Overcoming melanoma resistance to vemurafenib by targeting CCL2-induced miR-34a, miR-100 and miR-125b. mir-125b 93-101 C-C motif chemokine ligand 2 Homo sapiens 59-63 26684239-5 2016 Vemurafenib treatment increased the CCL2 levels in plasma, whereas the long-term clinical response was associated with low CCL2 levels.Increased CCL2 production was associated with miRNA deregulation in the resistant cells. Vemurafenib 0-11 C-C motif chemokine ligand 2 Homo sapiens 36-40 26608530-6 2016 The effect of MCP-1 in silicosis occurs mainly through MCPIP1, which, in turn, mediates the observed SiO2-induced increase in pulmonary fibroblast migration. Silicon Dioxide 101-105 C-C motif chemokine ligand 2 Homo sapiens 14-19 27069537-18 2016 Such phenomenon was completely reversed after administration of MCP-1 inhibitor (Bindarit). bindarit 81-89 C-C motif chemokine ligand 2 Homo sapiens 64-69 26909897-10 2016 In conclusion, both TLR4 and CCL2 were closely related to the occurrence of RSA, suggesting that serum TLR4 and CCL2 levels could be used as indices for monitoring RSA in pregnant women. rabbit sperm membrane autoantigen 76-79 C-C motif chemokine ligand 2 Homo sapiens 29-33 26909897-10 2016 In conclusion, both TLR4 and CCL2 were closely related to the occurrence of RSA, suggesting that serum TLR4 and CCL2 levels could be used as indices for monitoring RSA in pregnant women. rabbit sperm membrane autoantigen 76-79 C-C motif chemokine ligand 2 Homo sapiens 112-116 26909897-10 2016 In conclusion, both TLR4 and CCL2 were closely related to the occurrence of RSA, suggesting that serum TLR4 and CCL2 levels could be used as indices for monitoring RSA in pregnant women. rabbit sperm membrane autoantigen 164-167 C-C motif chemokine ligand 2 Homo sapiens 112-116 26683974-0 2016 Chronic Intracerebroventricular Infusion of Monocyte Chemoattractant Protein-1 Leads to a Persistent Increase in Sweetened Ethanol Consumption During Operant Self-Administration But Does Not Influence Sucrose Consumption in Long-Evans Rats. Ethanol 123-130 C-C motif chemokine ligand 2 Homo sapiens 44-78 26683974-1 2016 BACKGROUND: Among the evidence implicating neuroimmune signaling in alcohol use disorders are increased levels of the chemokine monocyte chemoattractant protein-1 (MCP-1) in the brains of human alcoholics and animal models of alcohol abuse. Alcohols 68-75 C-C motif chemokine ligand 2 Homo sapiens 128-162 26683974-1 2016 BACKGROUND: Among the evidence implicating neuroimmune signaling in alcohol use disorders are increased levels of the chemokine monocyte chemoattractant protein-1 (MCP-1) in the brains of human alcoholics and animal models of alcohol abuse. Alcohols 68-75 C-C motif chemokine ligand 2 Homo sapiens 164-169 26353790-10 2016 In PsA explant, tofacitinib significantly decreased spontaneous secretion of IL-6, IL-8, MCP-1, MMP9/MMP2, MMP3 (all p<0.05) and decreased the MMP3/TIMP3 ratio (p<0.05), with no effect observed for IP-10 or IL-10. tofacitinib 16-27 C-C motif chemokine ligand 2 Homo sapiens 89-94 26365696-3 2016 DESIGN AND METHODS: The detection of MCP-1 was achieved by performing a sandwich immunoassay on a silicon photonic microring resonator sensor platform. Silicon 98-105 C-C motif chemokine ligand 2 Homo sapiens 37-42 28018922-7 2016 MCP-1 was increased in the CFA and DFA groups at two and five months of age, as well as in DC5 when compared to CC5. Diphenylamine 35-38 C-C motif chemokine ligand 2 Homo sapiens 0-5 26481476-8 2016 Specifically, SA significantly increased the expression of Ccl5 (5.3-fold) and Mcp-1 (3.2-fold), and the secretion of IL-6 (17.8-fold) and MCP-1 (4.0-fold) in SCD1-inhibited adipocytes compared to controls. Stearates 14-16 C-C motif chemokine ligand 2 Homo sapiens 79-84 26481476-8 2016 Specifically, SA significantly increased the expression of Ccl5 (5.3-fold) and Mcp-1 (3.2-fold), and the secretion of IL-6 (17.8-fold) and MCP-1 (4.0-fold) in SCD1-inhibited adipocytes compared to controls. Stearates 14-16 C-C motif chemokine ligand 2 Homo sapiens 139-144 26481476-10 2016 The effects of PA, PMA and OA were not as substantial as those of SA, although PA did significantly increase Ccl5 (2.7-fold) and Mcp-1 (1.2-fold) expression in SCD1-inhibited adipocytes. Palmitates 79-81 C-C motif chemokine ligand 2 Homo sapiens 129-134 27340563-11 2016 The levels of monocyte chemoattractant protein-1 (MCP-1) and Chemokine (C-C Motif) Ligand 11 (CCL-11) were significantly higher in the CoCl2 than in the control (340.8 +- 43.3 versus 279.7 +- 68.3 pg/mL for MCP-1, and 15.2 +- 12.9 versus 12.5 +- 6.1 pg/mL for CCL-11. cobaltous chloride 135-140 C-C motif chemokine ligand 2 Homo sapiens 14-48 27340563-11 2016 The levels of monocyte chemoattractant protein-1 (MCP-1) and Chemokine (C-C Motif) Ligand 11 (CCL-11) were significantly higher in the CoCl2 than in the control (340.8 +- 43.3 versus 279.7 +- 68.3 pg/mL for MCP-1, and 15.2 +- 12.9 versus 12.5 +- 6.1 pg/mL for CCL-11. cobaltous chloride 135-140 C-C motif chemokine ligand 2 Homo sapiens 50-55 27340563-11 2016 The levels of monocyte chemoattractant protein-1 (MCP-1) and Chemokine (C-C Motif) Ligand 11 (CCL-11) were significantly higher in the CoCl2 than in the control (340.8 +- 43.3 versus 279.7 +- 68.3 pg/mL for MCP-1, and 15.2 +- 12.9 versus 12.5 +- 6.1 pg/mL for CCL-11. cobaltous chloride 135-140 C-C motif chemokine ligand 2 Homo sapiens 207-212 27988512-8 2016 By univariate analysis, glomerular filtration rate, EGF, and EGF/MCP-1 ratio were associated with IFTA. ifta 98-102 C-C motif chemokine ligand 2 Homo sapiens 65-70 27988512-9 2016 By multivariate analysis, only EGF/MCP-1 ratio was independently associated with IFTA. ifta 81-85 C-C motif chemokine ligand 2 Homo sapiens 35-40 27988512-10 2016 EGF/MCP-1 ratio had a sensitivity of 88% and specificity of 74 % for IFTA. ifta 69-73 C-C motif chemokine ligand 2 Homo sapiens 4-9 26765462-2 2016 Alpha-lipoic acid (ALA) is well known as a multifunctional antioxidant, helping to protect cells against oxidative stress and inflammatory damage.The aim of this study was to investigate the effects of ALA on intracellular production of reactive oxygen species (ROS), inflammation, and adipogenesis using primary cultured orbital fibroblasts from patients with GO.Intracellular ROS levels and mRNA expressions of proinflammatory cytokines and chemokines including intercellular adhesion molecule-1 (ICAM-1), interleukin (IL)-6, monocyte chemoattractant protein (MCP)-1, and regulated upon activation normal T cell expressed and presumably secreted (RANTES) were measured. Thioctic Acid 0-17 C-C motif chemokine ligand 2 Homo sapiens 528-568 26765462-2 2016 Alpha-lipoic acid (ALA) is well known as a multifunctional antioxidant, helping to protect cells against oxidative stress and inflammatory damage.The aim of this study was to investigate the effects of ALA on intracellular production of reactive oxygen species (ROS), inflammation, and adipogenesis using primary cultured orbital fibroblasts from patients with GO.Intracellular ROS levels and mRNA expressions of proinflammatory cytokines and chemokines including intercellular adhesion molecule-1 (ICAM-1), interleukin (IL)-6, monocyte chemoattractant protein (MCP)-1, and regulated upon activation normal T cell expressed and presumably secreted (RANTES) were measured. Thioctic Acid 19-22 C-C motif chemokine ligand 2 Homo sapiens 528-568 26765462-6 2016 Tumor necrosis factor (TNF)alpha-induced mRNA expressions of ICAM-1, IL-6, MCP-1, and RANTES were inhibited by ALA treatment. Thioctic Acid 111-114 C-C motif chemokine ligand 2 Homo sapiens 75-80 26011645-9 2016 These biomarkers increased moderately in response to NP exposure, except for MCP-1, which was reduced in HBE after AgNP treatment. agnp 115-119 C-C motif chemokine ligand 2 Homo sapiens 77-82 26490115-4 2015 MCP1, a G protein-coupled receptor agonist, activates phosphorylation of cortactin on S405 and S418 residues in a time-dependent manner, and inhibition of its phosphorylation attenuates MCP1-induced HASMC G-actin polymerization, F-actin stress fiber formation, and migration. hasmc 199-204 C-C motif chemokine ligand 2 Homo sapiens 0-4 26641100-7 2015 ANCE-induced IL-6, IL-8, and MCP-1 release was inhibited by IL-1 receptor antagonist and by an IKK2 inhibitor (a blocker of NF-kappaB signaling) in a concentration-dependent manner, but was not affected by a pan-caspase inhibitor (Z-VAD-FMK). ance 0-4 C-C motif chemokine ligand 2 Homo sapiens 29-34 26415685-0 2015 Unsaturated but not saturated fatty acids induce transcriptional regulation of CCL2 in pancreatic acini. unsaturated but 0-15 C-C motif chemokine ligand 2 Homo sapiens 79-83 26556845-7 2015 Thus, the results showed that cerivastatin was a potent inhibitor of the inflammation genes MCP-1 and CCR2 through the induction of KLF2. cerivastatin 30-42 C-C motif chemokine ligand 2 Homo sapiens 92-97 26556845-8 2015 The regulation of MCP-1, CCR2 and KLF2 by cerivastatin was isoprenoid pathway dependent. cerivastatin 42-54 C-C motif chemokine ligand 2 Homo sapiens 18-23 26556845-8 2015 The regulation of MCP-1, CCR2 and KLF2 by cerivastatin was isoprenoid pathway dependent. Terpenes 59-69 C-C motif chemokine ligand 2 Homo sapiens 18-23 25614126-8 2015 Incubation of cultured myofibroblasts derived from stenotic valves with sitostanol or sitosterol decreased mRNA expression of the monocyte chemotactic protein-1 (p < 0.05) and interleukin-1 beta (p < 0.05). stigmastanol 72-82 C-C motif chemokine ligand 2 Homo sapiens 130-160 25614126-8 2015 Incubation of cultured myofibroblasts derived from stenotic valves with sitostanol or sitosterol decreased mRNA expression of the monocyte chemotactic protein-1 (p < 0.05) and interleukin-1 beta (p < 0.05). gamma-sitosterol 86-96 C-C motif chemokine ligand 2 Homo sapiens 130-160 26507164-8 2015 We found that icariin inhibited TNF-alpha/IFN-gamma-induced IL-6, IL-8, IL-1beta, and MCP-1 production in a dose-dependent manner; meanwhile, the icariin treatment inhibited the gene expression of IL-8, IL-1beta, ICAM-1 and TACR1 in HaCaT cells in a time- and dose-dependent manner. icariin 14-21 C-C motif chemokine ligand 2 Homo sapiens 86-91 26714421-4 2015 METHODS: We measured the serum levels of MCP-1 in SAH patients who had CAs and compared it with that of MCP-1 in two control groups: including patients with SAH without CAs, and the normal population of blood donors. Calcium 71-74 C-C motif chemokine ligand 2 Homo sapiens 41-46 26714421-7 2015 RESULTS: Mean serum MCP-1 level in patients with SAH and CAs was 188.2168 Pg/ml and 331.3982 Pg/ml in the normal population. Calcium 57-60 C-C motif chemokine ligand 2 Homo sapiens 20-25 26714421-11 2015 There was a relationship between poor clinical grade and MCP-1 levels in patients with CAs. Calcium 87-90 C-C motif chemokine ligand 2 Homo sapiens 57-62 25715004-5 2015 RESULTS: Latanoprost stimulated the release of IL-6, IL-8, and MCP-1 from HTFs in a concentration-dependent and time-dependent manner, whereas timolol maleate and pilocarpine had no such effects. Latanoprost 9-20 C-C motif chemokine ligand 2 Homo sapiens 63-68 25715004-5 2015 RESULTS: Latanoprost stimulated the release of IL-6, IL-8, and MCP-1 from HTFs in a concentration-dependent and time-dependent manner, whereas timolol maleate and pilocarpine had no such effects. htfs 74-78 C-C motif chemokine ligand 2 Homo sapiens 63-68 26769828-10 2015 Moreover, the TLR6, NO, iNOS, IL-1beta, MCP-1, and the keratinocyte chemoattractant (KC) levels significantly decreased in the zymosan-stimulated groups maintained in riboflavin-enriched medium. Zymosan 127-134 C-C motif chemokine ligand 2 Homo sapiens 40-45 26554595-9 2016 The membrane-permeant calcium chelator BAPTA-AM reduced ES-induced CCL2 secretion. Calcium 22-29 C-C motif chemokine ligand 2 Homo sapiens 67-71 26554595-9 2016 The membrane-permeant calcium chelator BAPTA-AM reduced ES-induced CCL2 secretion. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 39-47 C-C motif chemokine ligand 2 Homo sapiens 67-71 26949603-7 2016 RESULTS: Triptolide inhibited the zymosan-induced release of IL-6, IL-8, and MCP-1 from HCFs in a concentration- and time-dependent manner. triptolide 9-19 C-C motif chemokine ligand 2 Homo sapiens 77-82 26949603-7 2016 RESULTS: Triptolide inhibited the zymosan-induced release of IL-6, IL-8, and MCP-1 from HCFs in a concentration- and time-dependent manner. Zymosan 34-41 C-C motif chemokine ligand 2 Homo sapiens 77-82 26603571-7 2016 Meanwhile, the expression of monocyte chemotactic protein-1 (MCP-1) was decreased by miR-125b-5p mimics treatment in THP-1 macrophages. mir-125b-5p 85-96 C-C motif chemokine ligand 2 Homo sapiens 29-59 26603571-7 2016 Meanwhile, the expression of monocyte chemotactic protein-1 (MCP-1) was decreased by miR-125b-5p mimics treatment in THP-1 macrophages. mir-125b-5p 85-96 C-C motif chemokine ligand 2 Homo sapiens 61-66 26603571-9 2016 In addition, the upregulation of MCP-1 expression through miR-125b-5p inhibitors was attenuate by siRNA-LACTB treatment in LPS-stimulated THP-1 macrophages. mir-125b 58-66 C-C motif chemokine ligand 2 Homo sapiens 33-38 26603571-9 2016 In addition, the upregulation of MCP-1 expression through miR-125b-5p inhibitors was attenuate by siRNA-LACTB treatment in LPS-stimulated THP-1 macrophages. CHEMBL3740941 67-69 C-C motif chemokine ligand 2 Homo sapiens 33-38 26603571-10 2016 CONCLUSIONS: MiR-125b-5p attenuates the secretion of MCP-1 by directly targeting inhibiting LACTB in LPS-stimulated THP-1 macrophages. 125b 17-21 C-C motif chemokine ligand 2 Homo sapiens 53-58 27007532-10 2016 In the Zn-H group, levels of G-CSF and MCP-1 were significantly higher by 70% and 145%, respectively, compared to the Zn-L group. zn-h 7-11 C-C motif chemokine ligand 2 Homo sapiens 39-44 26722037-4 2016 The three selected synthetic stilbenes (at concentrations of 5, 10, 25, and 50 muM) inhibited the production of interleukin-10 and monocyte chemoattractant protein-1 in M2 macrophages, but promoted that of transforming growth factor-beta1. Stilbenes 29-38 C-C motif chemokine ligand 2 Homo sapiens 131-165 26722041-5 2016 Itraconazole also suppressed monocyte chemoattractant protein-1 secretion and the growth of CAFs. Itraconazole 0-12 C-C motif chemokine ligand 2 Homo sapiens 29-63 26492523-11 2016 Aspirin, U0126, LY294002 and 5z-7-oxozeaenol attenuated the IL-1beta-induced MCP-1 expression. Aspirin 0-7 C-C motif chemokine ligand 2 Homo sapiens 77-82 26492523-11 2016 Aspirin, U0126, LY294002 and 5z-7-oxozeaenol attenuated the IL-1beta-induced MCP-1 expression. U 0126 9-14 C-C motif chemokine ligand 2 Homo sapiens 77-82 26492523-11 2016 Aspirin, U0126, LY294002 and 5z-7-oxozeaenol attenuated the IL-1beta-induced MCP-1 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 16-24 C-C motif chemokine ligand 2 Homo sapiens 77-82 26492523-11 2016 Aspirin, U0126, LY294002 and 5z-7-oxozeaenol attenuated the IL-1beta-induced MCP-1 expression. 5-7-oxo-zeaenol 29-44 C-C motif chemokine ligand 2 Homo sapiens 77-82 27190988-9 2016 We found that Hcy could induce cell apoptosis with corresponding decrease of nitric oxide (NO) level, increase of endothelin-1 (ET-1), intracellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1), and monocyte chemoattractant protein-1 (MCP-1) levels, elevation of ROS, and dissipation of MMP. Homocysteine 14-17 C-C motif chemokine ligand 2 Homo sapiens 231-265 27190988-9 2016 We found that Hcy could induce cell apoptosis with corresponding decrease of nitric oxide (NO) level, increase of endothelin-1 (ET-1), intracellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1), and monocyte chemoattractant protein-1 (MCP-1) levels, elevation of ROS, and dissipation of MMP. Homocysteine 14-17 C-C motif chemokine ligand 2 Homo sapiens 267-272 26499899-0 2016 Elevated circulating monocyte chemoattractant protein 1 (MCP-1/CCL-2) level may be an unfavorable predictive factor to platinum- and taxane-based combination chemotherapy in patients with gastric cancer. Platinum 119-127 C-C motif chemokine ligand 2 Homo sapiens 21-55 26499899-0 2016 Elevated circulating monocyte chemoattractant protein 1 (MCP-1/CCL-2) level may be an unfavorable predictive factor to platinum- and taxane-based combination chemotherapy in patients with gastric cancer. Platinum 119-127 C-C motif chemokine ligand 2 Homo sapiens 57-62 26499899-0 2016 Elevated circulating monocyte chemoattractant protein 1 (MCP-1/CCL-2) level may be an unfavorable predictive factor to platinum- and taxane-based combination chemotherapy in patients with gastric cancer. Platinum 119-127 C-C motif chemokine ligand 2 Homo sapiens 63-68 26499899-0 2016 Elevated circulating monocyte chemoattractant protein 1 (MCP-1/CCL-2) level may be an unfavorable predictive factor to platinum- and taxane-based combination chemotherapy in patients with gastric cancer. taxane 133-139 C-C motif chemokine ligand 2 Homo sapiens 21-55 26499899-0 2016 Elevated circulating monocyte chemoattractant protein 1 (MCP-1/CCL-2) level may be an unfavorable predictive factor to platinum- and taxane-based combination chemotherapy in patients with gastric cancer. taxane 133-139 C-C motif chemokine ligand 2 Homo sapiens 57-62 26499899-0 2016 Elevated circulating monocyte chemoattractant protein 1 (MCP-1/CCL-2) level may be an unfavorable predictive factor to platinum- and taxane-based combination chemotherapy in patients with gastric cancer. taxane 133-139 C-C motif chemokine ligand 2 Homo sapiens 63-68 26499899-13 2016 CONCLUSION: Elevated circulating MCP-1/CCL-2 level may be an unfavorable predictive factor to chemotherapy based on platinum and taxane in patients with gastric cancer. Platinum 116-124 C-C motif chemokine ligand 2 Homo sapiens 33-38 26499899-13 2016 CONCLUSION: Elevated circulating MCP-1/CCL-2 level may be an unfavorable predictive factor to chemotherapy based on platinum and taxane in patients with gastric cancer. Platinum 116-124 C-C motif chemokine ligand 2 Homo sapiens 39-44 26499899-13 2016 CONCLUSION: Elevated circulating MCP-1/CCL-2 level may be an unfavorable predictive factor to chemotherapy based on platinum and taxane in patients with gastric cancer. taxane 129-135 C-C motif chemokine ligand 2 Homo sapiens 33-38 26499899-13 2016 CONCLUSION: Elevated circulating MCP-1/CCL-2 level may be an unfavorable predictive factor to chemotherapy based on platinum and taxane in patients with gastric cancer. taxane 129-135 C-C motif chemokine ligand 2 Homo sapiens 39-44 27889767-8 2016 RESULTS: Upon Lipopolysaccharide (LPS)-induced inflammatory response in HUVECs, Crocetin ameliorated cell cytotoxicity, suppressed MCP-1 and IL-8 expressions through blocking NF-kappaB p65 signaling transduction. crocetin 80-88 C-C motif chemokine ligand 2 Homo sapiens 131-136 26667367-5 2016 CS levels of pentraxin 3 and monocyte chemoattractant protein-1 were lower after than before treatment with EPA (3.3 +- 2.1 to 2.6 +- 1.2 ng/ml, 120.4 +- 26.2 to 110.2 +- 26.8 pg/ml, P=0.015 and P=0.008, respectively); however, there were no significant changes in those inflammatory cytokines between pre- and post-treatment in the control group. Eicosapentaenoic Acid 108-111 C-C motif chemokine ligand 2 Homo sapiens 29-63 27633039-0 2016 Relationships Between Metformin, Paraoxonase-1 and the Chemokine (C-C Motif) Ligand 2. Metformin 22-31 C-C motif chemokine ligand 2 Homo sapiens 55-85 27797602-7 2016 RESULTS: Bleomycin increased intercellular adhesion molecule 1 (ICAM-1; CD54), vascular cell adhesion molecule (VCAM-1; CD106), and E-selectin (CD62E) expression, and increased monocyte chemoattractant protein (MCP-1) and interleukin (IL-8) release by endothelial cells. Bleomycin 9-18 C-C motif chemokine ligand 2 Homo sapiens 211-216 26662286-7 2016 Either silencing of Notch1 by siRNA or pharmacological inhibition of Notch signaling by DAPT prevented the loss of cell viability, and induction of apoptosis, and enhanced expression Notch1, Hes1 and MCP-1 by LPC in HUVECs. dapt 88-92 C-C motif chemokine ligand 2 Homo sapiens 200-205 26839895-4 2016 The aim of the study is to investigate the relationship between these polymorphisms with soluble CCL2 levels (sCCL2), metabolic markers, and adiposity. sccl2 110-115 C-C motif chemokine ligand 2 Homo sapiens 97-101 26430781-7 2016 The mbIL-12-mediated decrease in tumor burden was associated with a significant reduction in neutrophil and macrophage infiltration in the OFB, and correlated with a reduced expression of neutrophil and macrophage chemoattractants (CXCL1, -2, -3 and CCL2, -7). mbil-12 4-11 C-C motif chemokine ligand 2 Homo sapiens 250-254 26767865-5 2016 RESULTS: Ang III increased MCP-1 protein production in dose- and time-dependent manners in HK-2 cells, which was inhibited by the AT1 receptor blocker losartan. Losartan 151-159 C-C motif chemokine ligand 2 Homo sapiens 27-32 26767865-8 2016 Pre-treatment with a p38 inhibitor, a JNK inhibitor, or curcumin significantly inhibited Ang III-induced MCP-1 production. Curcumin 56-64 C-C motif chemokine ligand 2 Homo sapiens 105-110 27881903-0 2016 Forskolin Inhibits Lipopolysaccharide-Induced Modulation of MCP-1 and GPR120 in 3T3-L1 Adipocytes through an Inhibition of NFkappaB. Colforsin 0-9 C-C motif chemokine ligand 2 Homo sapiens 60-65 27881903-3 2016 The aim of this study was to determine the signaling pathway by which Forskolin (FK), a cyclic adenosine monophosphate- (cAMP-) promoting agent causing positive changes in body composition in overweight and obese adult men, affects MCP-1 and GPR120 expression during an inflammatory response induced by lipopolysaccharide (LPS) in adipocytes, such as in an obese state. Colforsin 70-79 C-C motif chemokine ligand 2 Homo sapiens 232-237 26740864-8 2016 Changes in IL-8, MIP-1beta, and MCP-1 serum concentrations may be associated with efficacy of pegIFNalpha- and ribavirin-based therapies in patients coinfected by HCV and HIV. pegifnalpha 94-105 C-C motif chemokine ligand 2 Homo sapiens 32-37 26740864-8 2016 Changes in IL-8, MIP-1beta, and MCP-1 serum concentrations may be associated with efficacy of pegIFNalpha- and ribavirin-based therapies in patients coinfected by HCV and HIV. Ribavirin 111-120 C-C motif chemokine ligand 2 Homo sapiens 32-37 27296256-10 2016 Clusterin, MCP-1 and KIM-1 positively and significantly correlated with serum creatinine at the week following the determination of BMs in the multivariate linear regression models adjusted for other confounders. Creatinine 78-88 C-C motif chemokine ligand 2 Homo sapiens 11-16 26723683-3 2015 The HCCCl precursor is produced by microwave discharge of a mixture of a matrix gas with trichloroethylene (HClC=CCl2). hcccl 4-9 C-C motif chemokine ligand 2 Homo sapiens 113-117 26723683-3 2015 The HCCCl precursor is produced by microwave discharge of a mixture of a matrix gas with trichloroethylene (HClC=CCl2). Trichloroethylene 89-106 C-C motif chemokine ligand 2 Homo sapiens 113-117 26723683-3 2015 The HCCCl precursor is produced by microwave discharge of a mixture of a matrix gas with trichloroethylene (HClC=CCl2). hclc 108-112 C-C motif chemokine ligand 2 Homo sapiens 113-117 26152744-6 2015 RESULTS: In late-stage cancer patients, plasma levels of multiple biomarkers, including IL6, G-CSF, MCP-1, and MIP1-beta, increased with increasing motolimod dose. VTX-2337 148-157 C-C motif chemokine ligand 2 Homo sapiens 100-105 26556845-3 2015 Cerivastatin significantly inhibited the two atherosclerotic genes, monocyte chemoattractant protein-1 (MCP-1) and C-C chemokine receptor type 2 (CCR2) at both the mRNA and protein levels, while the other statins did not. cerivastatin 0-12 C-C motif chemokine ligand 2 Homo sapiens 68-102 26556845-3 2015 Cerivastatin significantly inhibited the two atherosclerotic genes, monocyte chemoattractant protein-1 (MCP-1) and C-C chemokine receptor type 2 (CCR2) at both the mRNA and protein levels, while the other statins did not. cerivastatin 0-12 C-C motif chemokine ligand 2 Homo sapiens 104-109 26556845-5 2015 An siRNA-induced reduction in KLF2 expression blocked the inhibition of MCP-1 and CCR2 by cerivastatin. cerivastatin 90-102 C-C motif chemokine ligand 2 Homo sapiens 72-77 26556845-6 2015 When the cells were further treated with mevalonate, farnesylpyrophosphate (FPP) or geranylgeranyl pyrophosphate (GGPP), the effects of cerivastatin on KLF2, MCP-1 and CCR2 were obviously reversed. geranylgeranyl pyrophosphate 84-112 C-C motif chemokine ligand 2 Homo sapiens 158-163 26396259-11 2015 Moreover, cytosporone B, an NR4A1 agonist, completely reversed cholesterol-induced IL-6 (interleukin 6) and MCP-1 (monocyte chemoattractant protein 1) expression to below basal levels, and knockdown of NR4A1 expression by siRNA not only mimicked, but also exaggerated the effects of cholesterol on inflammatory biomarker up-regulation. cytosporone B 10-23 C-C motif chemokine ligand 2 Homo sapiens 108-113 26396259-11 2015 Moreover, cytosporone B, an NR4A1 agonist, completely reversed cholesterol-induced IL-6 (interleukin 6) and MCP-1 (monocyte chemoattractant protein 1) expression to below basal levels, and knockdown of NR4A1 expression by siRNA not only mimicked, but also exaggerated the effects of cholesterol on inflammatory biomarker up-regulation. cytosporone B 10-23 C-C motif chemokine ligand 2 Homo sapiens 115-149 26396259-11 2015 Moreover, cytosporone B, an NR4A1 agonist, completely reversed cholesterol-induced IL-6 (interleukin 6) and MCP-1 (monocyte chemoattractant protein 1) expression to below basal levels, and knockdown of NR4A1 expression by siRNA not only mimicked, but also exaggerated the effects of cholesterol on inflammatory biomarker up-regulation. Cholesterol 63-74 C-C motif chemokine ligand 2 Homo sapiens 108-113 26396259-11 2015 Moreover, cytosporone B, an NR4A1 agonist, completely reversed cholesterol-induced IL-6 (interleukin 6) and MCP-1 (monocyte chemoattractant protein 1) expression to below basal levels, and knockdown of NR4A1 expression by siRNA not only mimicked, but also exaggerated the effects of cholesterol on inflammatory biomarker up-regulation. Cholesterol 63-74 C-C motif chemokine ligand 2 Homo sapiens 115-149 26293782-3 2015 In an animal model of sepsis, EGCG significantly elevated peritoneal levels of G-CSF and several chemokines (e.g., MCP-1/CCL2 and MIP-1gamma/CCL9), and consequently increased peritoneal neutrophil numbers (neutrophilia) at a late stage. epigallocatechin gallate 30-34 C-C motif chemokine ligand 2 Homo sapiens 115-120 26293782-3 2015 In an animal model of sepsis, EGCG significantly elevated peritoneal levels of G-CSF and several chemokines (e.g., MCP-1/CCL2 and MIP-1gamma/CCL9), and consequently increased peritoneal neutrophil numbers (neutrophilia) at a late stage. epigallocatechin gallate 30-34 C-C motif chemokine ligand 2 Homo sapiens 121-125 26507164-8 2015 We found that icariin inhibited TNF-alpha/IFN-gamma-induced IL-6, IL-8, IL-1beta, and MCP-1 production in a dose-dependent manner; meanwhile, the icariin treatment inhibited the gene expression of IL-8, IL-1beta, ICAM-1 and TACR1 in HaCaT cells in a time- and dose-dependent manner. icariin 146-153 C-C motif chemokine ligand 2 Homo sapiens 86-91 26053326-4 2015 Poly(ethylene glycol) (PEG)-containing hydrogels (PEG and an interpenetrating network of PEG and gelatin) promote the release of the alpha-defensins human neutrophil peptides 1-3, but not azurocidin or monocyte chemotactic protein-1. Polyethylene Glycols 0-21 C-C motif chemokine ligand 2 Homo sapiens 202-232 26053326-4 2015 Poly(ethylene glycol) (PEG)-containing hydrogels (PEG and an interpenetrating network of PEG and gelatin) promote the release of the alpha-defensins human neutrophil peptides 1-3, but not azurocidin or monocyte chemotactic protein-1. Polyethylene Glycols 23-26 C-C motif chemokine ligand 2 Homo sapiens 202-232 25715004-7 2015 The latanoprost-induced release of IL-6, IL-8, and MCP-1 was attenuated by inhibitors of MAPK (PD98059, SB203580, or JNK inhibitor II) or NF-kappaB (IkappaB kinase 2 inhibitor) signaling pathways. Latanoprost 4-15 C-C motif chemokine ligand 2 Homo sapiens 51-56 25715004-7 2015 The latanoprost-induced release of IL-6, IL-8, and MCP-1 was attenuated by inhibitors of MAPK (PD98059, SB203580, or JNK inhibitor II) or NF-kappaB (IkappaB kinase 2 inhibitor) signaling pathways. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 95-102 C-C motif chemokine ligand 2 Homo sapiens 51-56 25715004-7 2015 The latanoprost-induced release of IL-6, IL-8, and MCP-1 was attenuated by inhibitors of MAPK (PD98059, SB203580, or JNK inhibitor II) or NF-kappaB (IkappaB kinase 2 inhibitor) signaling pathways. SB 203580 104-112 C-C motif chemokine ligand 2 Homo sapiens 51-56 26407807-7 2015 Activation of AMPK, using two pharmacologically distinct compounds, AICAR or phenformin, significantly suppressed LPS- or IL-1beta-induced gene expression and secretion of pro-inflammatory cytokine IL-6, the chemokines IL-8 and MCP-1, and COX-2 and subsequent prostaglandin release from adipose tissue and skeletal muscle. Phenformin 77-87 C-C motif chemokine ligand 2 Homo sapiens 228-233 26788115-6 2016 DHA alone attenuated the secretion of pro-inflammatory adipokines such as chemerin, interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1/CCL2), whereas AC suppressed only the latter two. Docosahexaenoic Acids 0-3 C-C motif chemokine ligand 2 Homo sapiens 145-150 26788115-6 2016 DHA alone attenuated the secretion of pro-inflammatory adipokines such as chemerin, interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1/CCL2), whereas AC suppressed only the latter two. Docosahexaenoic Acids 0-3 C-C motif chemokine ligand 2 Homo sapiens 151-155 26739470-10 2015 CONCLUSION: Stimulation of hepatocytes by the PA fatty acid in vitro promotes mRNA expression of TNF-alpha, MCP-1 and IL-8, but overexpression of JAZF1 inhibits the PA-induced expression and secretion of these factors. pa fatty acid 46-59 C-C motif chemokine ligand 2 Homo sapiens 108-113 26291279-3 2015 Significant increases were seen in the release of IL-6, MCP-1/CCL2, RANTES/CCL5 and KC/CXCL1 and this release was inhibited by treatment with Brefeldin A, suggesting a golgi-mediated release of cytokines by muscle cells. Brefeldin A 142-153 C-C motif chemokine ligand 2 Homo sapiens 56-61 26291279-3 2015 Significant increases were seen in the release of IL-6, MCP-1/CCL2, RANTES/CCL5 and KC/CXCL1 and this release was inhibited by treatment with Brefeldin A, suggesting a golgi-mediated release of cytokines by muscle cells. Brefeldin A 142-153 C-C motif chemokine ligand 2 Homo sapiens 62-66 26143161-10 2015 MCP-1 had a negative correlation with LDL cholesterol (p = 0.026) and ESR (p = 0.017). Cholesterol 42-53 C-C motif chemokine ligand 2 Homo sapiens 0-5 26739470-10 2015 CONCLUSION: Stimulation of hepatocytes by the PA fatty acid in vitro promotes mRNA expression of TNF-alpha, MCP-1 and IL-8, but overexpression of JAZF1 inhibits the PA-induced expression and secretion of these factors. Palmitic Acid 46-48 C-C motif chemokine ligand 2 Homo sapiens 108-113 26583035-8 2015 HK2 cells exposed to high glucose had reduced FXR expression and increased MCP-1, TGF-beta1, fibronectin and collagen IV expression, which was reversed in the presence of GW4064. Glucose 26-33 C-C motif chemokine ligand 2 Homo sapiens 75-80 26474699-6 2015 Inhibition of MEK or PI3K resulted in significantly attenuated expression of CCL2, along with that of MMP-9, induced by 7alphaOHChol. 7alphaohchol 120-132 C-C motif chemokine ligand 2 Homo sapiens 77-81 26474699-7 2015 We propose that elevated concentration of a certain type of 7-oxygenated cholesterol derivative, like 7alphaOHChol, leads to inflammation via upregulation of CCL2 and MMP-9 in macrophages in the artery, thereby promoting progression of atherosclerosis, and the ERK and the PI3K pathways are involved in the process. Cholesterol 73-84 C-C motif chemokine ligand 2 Homo sapiens 158-162 26474699-7 2015 We propose that elevated concentration of a certain type of 7-oxygenated cholesterol derivative, like 7alphaOHChol, leads to inflammation via upregulation of CCL2 and MMP-9 in macrophages in the artery, thereby promoting progression of atherosclerosis, and the ERK and the PI3K pathways are involved in the process. 7alphaohchol 102-114 C-C motif chemokine ligand 2 Homo sapiens 158-162 26572585-4 2015 EC overexpression of mutant ITGB4 with specific tyrosines mutated to phenylalanine (Y1440, Y1526 Y1640, or Y1422) resulted in significantly attenuated CS-induced cytokine expression (IL6, IL-8, MCP-1, and RANTES). Cesium 151-153 C-C motif chemokine ligand 2 Homo sapiens 194-199 26618488-5 2015 Early Ly-6Chi monocyte recruitment was governed by CCL2 produced from hematopoietic stem cell (HSC)-derived leukocytes, whereas NK cell recruitment predominantly depended on CC chemokines produced by resident epithelial cells. ly-6chi 6-13 C-C motif chemokine ligand 2 Homo sapiens 51-55 26474699-0 2015 7alpha-Hydroxycholesterol induces inflammation by enhancing production of chemokine (C-C motif) ligand 2. cholest-5-en-3 beta,7 alpha-diol 0-25 C-C motif chemokine ligand 2 Homo sapiens 74-104 26474699-2 2015 Treatment of THP-1 monocyte/macrophage with 7alpha-hydroxycholesterol (7alphaOHChol) resulted in increased gene transcription of CCL2 and production of its corresponding protein. cholest-5-en-3 beta,7 alpha-diol 44-69 C-C motif chemokine ligand 2 Homo sapiens 129-133 26474699-2 2015 Treatment of THP-1 monocyte/macrophage with 7alpha-hydroxycholesterol (7alphaOHChol) resulted in increased gene transcription of CCL2 and production of its corresponding protein. 7alphaohchol 71-83 C-C motif chemokine ligand 2 Homo sapiens 129-133 26583035-8 2015 HK2 cells exposed to high glucose had reduced FXR expression and increased MCP-1, TGF-beta1, fibronectin and collagen IV expression, which was reversed in the presence of GW4064. GW 4064 171-177 C-C motif chemokine ligand 2 Homo sapiens 75-80 26407820-9 2015 CONCLUSIONS: Urinary KIM-1 and MCP-1, either alone or in combination, may represent biomarkers of cisplatin-induced AKI in lung cancer patients. Cisplatin 98-107 C-C motif chemokine ligand 2 Homo sapiens 31-36 26508036-5 2015 Carbon atom displacements almost completely account for the differences in the symmetric and asymmetric CCl2 stretching intensities of dichloromethane, 103.9 of the total calculated value of 105.2 km mol(-1). Carbon 0-6 C-C motif chemokine ligand 2 Homo sapiens 104-108 26508036-5 2015 Carbon atom displacements almost completely account for the differences in the symmetric and asymmetric CCl2 stretching intensities of dichloromethane, 103.9 of the total calculated value of 105.2 km mol(-1). Methylene Chloride 135-150 C-C motif chemokine ligand 2 Homo sapiens 104-108 24840272-10 2015 Secretion of the proliferative factor, monocyte chemoattractant protein (MCP)-1, significantly increased during the first 6 hours of incubation with 480 muM Ni(2+)-treated medium. Nickel(2+) 157-163 C-C motif chemokine ligand 2 Homo sapiens 39-79 26354876-8 2015 This compound behaves like the prototypic AhR ligand 6-formylindolo[3,2-b]carbazole, a cutaneous UV light-induced tryptophan metabolite, both promoting IL-22, IL-8, and CCL2 secretion by T-cells and macrophages. 6-formylindolo(3,2-b)carbazole 53-83 C-C motif chemokine ligand 2 Homo sapiens 169-173 26407820-0 2015 Urinary kidney injury molecule-1 and monocyte chemotactic protein-1 are noninvasive biomarkers of cisplatin-induced nephrotoxicity in lung cancer patients. Cisplatin 98-107 C-C motif chemokine ligand 2 Homo sapiens 37-67 26348774-4 2015 The inhibitory mechanism of Edaravone was associated with suppression of the chemokine MCP-1 and adhesion molecule VCAM-1 and ICAM-1 expression. Edaravone 28-37 C-C motif chemokine ligand 2 Homo sapiens 87-121 26467463-9 2015 RESULTS: Metformin induced single-cultured RAW264.7 macrophages with an M2 phenotype but attenuated the M2 macrophage differentiation and inhibited monocyte chemoattractant protein-1 (MCP-1) secretion in a co-culture system. Metformin 9-18 C-C motif chemokine ligand 2 Homo sapiens 148-182 26467463-9 2015 RESULTS: Metformin induced single-cultured RAW264.7 macrophages with an M2 phenotype but attenuated the M2 macrophage differentiation and inhibited monocyte chemoattractant protein-1 (MCP-1) secretion in a co-culture system. Metformin 9-18 C-C motif chemokine ligand 2 Homo sapiens 184-189 26099791-9 2015 Hyperosmolar HES 200/0.5 and albumin showed significantly different pattern of recovery with increased concentration of MIG, IP-10, C3a and C5a and decreased concentration of IL-1beta, TNF, MCP-1 and IL-8 in comparison with dextran 60. Hydroxyethyl Starch Derivatives 13-16 C-C motif chemokine ligand 2 Homo sapiens 190-195 26058873-8 2015 CCL2 and CXCL16 expression levels and cell proliferation were significantly inhibited by U0126 in a dose- and time-dependent manner. U 0126 89-94 C-C motif chemokine ligand 2 Homo sapiens 0-4 25715999-9 2015 Ang II promoted the migration of monocytes through endothelial cells and the secretion of MCP-1 from human umbilical vein endothelial cells in vitro, which was inhibited by TRAM-34. TRAM 34 173-180 C-C motif chemokine ligand 2 Homo sapiens 90-95 26491301-8 2015 Following, by using specific MAPK inhibitors, we observed that lipopolysaccharide-induced production of monocyte chemotactic protein-1 and nitric oxide was significantly inhibited on the Ti/TiO2 surface via p38 and ERK1/2, but not via JNK. titanium dioxide 190-194 C-C motif chemokine ligand 2 Homo sapiens 104-134 26518714-7 2015 We found a significant association between MCP-1 -2518 polymorphism and TB susceptibility only in the East Asian and Latin American groups (OR 3.47, P = 0.08; OR 2.73, P = 0.02). Terbium 72-74 C-C motif chemokine ligand 2 Homo sapiens 43-48 26518714-9 2015 CONCLUSIONS: There is an association between MCP-1 -2518 polymorphism and TB susceptibility only in the East Asian and Latin American groups. Terbium 74-76 C-C motif chemokine ligand 2 Homo sapiens 45-50 26460736-9 2015 Neutrophils treated with a2NTD (a2Neuphi) showed increased secretion of IL-1RA, IL-10, CCL-2 and IL-6 that are important mediators in cancer related inflammation. a2ntd 25-30 C-C motif chemokine ligand 2 Homo sapiens 87-92 26455502-9 2015 In conclusion, CCL2 downregulation in SA may be an attempt to protect muscle against macrophage infiltration, and defects in fatty acid partitioning to muscle may lead to the disproportionate adiposity and adverse cardiometabolic profile in SA. sa 38-40 C-C motif chemokine ligand 2 Homo sapiens 15-19 26455502-9 2015 In conclusion, CCL2 downregulation in SA may be an attempt to protect muscle against macrophage infiltration, and defects in fatty acid partitioning to muscle may lead to the disproportionate adiposity and adverse cardiometabolic profile in SA. sa 241-243 C-C motif chemokine ligand 2 Homo sapiens 15-19 26163174-3 2015 Clinical evidence indicates that the activation of alveolar macrophages by SiO2 produces rapid and sustained inflammation that is characterized by the generation of monocyte chemotactic protein 1 (MCP-1), which induces fibrosis. Silicon Dioxide 75-79 C-C motif chemokine ligand 2 Homo sapiens 165-195 26163174-3 2015 Clinical evidence indicates that the activation of alveolar macrophages by SiO2 produces rapid and sustained inflammation that is characterized by the generation of monocyte chemotactic protein 1 (MCP-1), which induces fibrosis. Silicon Dioxide 75-79 C-C motif chemokine ligand 2 Homo sapiens 197-202 26163174-6 2015 CONCLUSION: These data demonstrated that the up-regulation of pulmonary fibroblast-derived MCP-1 is involved in pulmonary fibroblast migration induced by SiO2. Silicon Dioxide 154-158 C-C motif chemokine ligand 2 Homo sapiens 91-96 26163174-7 2015 CCR2 was also up-regulated in response to SiO2, and this up-regulation facilitated the effect of MCP-1 on fibroblasts. Silicon Dioxide 42-46 C-C motif chemokine ligand 2 Homo sapiens 97-102 26491301-9 2015 However, the selective inhibitor for JNK signaling pathway (SP600125) was effective in reducing tumor necrosis factor alpha release as well as monocyte chemotactic protein-1 and nitric oxide production. pyrazolanthrone 60-68 C-C motif chemokine ligand 2 Homo sapiens 143-173 26166377-8 2015 The results of the present study demonstrated that berberine significantly inhibited the TNF-alpha-induced expression of ICAM-1 and MCP-1, as well as the activation of NF-kappaB in the HAECs. Berberine 51-60 C-C motif chemokine ligand 2 Homo sapiens 132-137 26284488-9 2015 The search for mediators of senescent HPMC activity showed that increased SW480 cell proliferation was stimulated by IL-6, migration by CXCL8 and CCL2, invasion by IL-6, MMP-3 and uPA, and epithelial-mesenchymal transition by TGF-beta1. Hypromellose Derivatives 38-42 C-C motif chemokine ligand 2 Homo sapiens 146-150 26156105-10 2015 Losartan and PDTC reduced the expression of IL-1alpha, MCP-1, and IL-10, and the number of dilated capillaries and capillaries with endothelial detachment. Losartan 0-8 C-C motif chemokine ligand 2 Homo sapiens 55-60 26209236-8 2015 These changes were accompanied by an attenuation of BLM-induced elevations in pulmonary levels of profibrotic cytokines interleukin-6, monocyte chemoattractant protein-1, and transforming growth factor-beta (TGF-beta). Bleomycin 52-55 C-C motif chemokine ligand 2 Homo sapiens 135-169 26166377-10 2015 In conclusion, the results of the present study indicated that berberine inhibits the TNF-alpha-induced expression of ICAM-1 and MCP-1, and the activation of NF-kappaB in HAECs in vitro, possibly through the AMPK-dependent pathway. Berberine 63-72 C-C motif chemokine ligand 2 Homo sapiens 129-134 26093057-0 2015 Roles of chemokines CCL2 and CCL5 in the pharmacokinetics of PEGylated liposomal doxorubicin in vivo and in patients with recurrent epithelial ovarian cancer. Doxorubicin 81-92 C-C motif chemokine ligand 2 Homo sapiens 20-24 26093057-6 2015 Plasma exposure of encapsulated liposomal doxorubicin positively correlated with the total exposure of plasma CCL2 and CCL5 in patients with recurrent epithelial ovarian cancer treated with PLD. Doxorubicin 42-53 C-C motif chemokine ligand 2 Homo sapiens 110-114 26187356-8 2015 In addition, gemigliptin diminished TNF-alpha-mediated cell adhesion molecules such as MCP-1 and VCAM-1 and reduced MMP2 activity in VSMCs. LC15-0444 13-24 C-C motif chemokine ligand 2 Homo sapiens 87-92 26407865-6 2015 Noteworthy, the migration capacity of PA-MSCs of second passage was significantly improved after stimulation with FGF-2 (P < 0.02), PDGF-BB (P < 0.006), MCP-1 (P < 0.002) and IL-6 (P < 0.03), whereas only TGF-beta enhanced significantly migration process of PA-MSCs of P4 12 h after the treatment (P < 0.02). Protactinium 38-40 C-C motif chemokine ligand 2 Homo sapiens 159-164 26183340-6 2015 The lowest quantification limits for the assay of MCP-1 (1 pg mL(-1)) were reached when the microsensors based on protoporphyrin IX/Graphene-Au-3 and on MD/Graphene were employed in the platform design. protoporphyrin IX 114-131 C-C motif chemokine ligand 2 Homo sapiens 50-55 26183340-6 2015 The lowest quantification limits for the assay of MCP-1 (1 pg mL(-1)) were reached when the microsensors based on protoporphyrin IX/Graphene-Au-3 and on MD/Graphene were employed in the platform design. Graphite 132-140 C-C motif chemokine ligand 2 Homo sapiens 50-55 26183340-6 2015 The lowest quantification limits for the assay of MCP-1 (1 pg mL(-1)) were reached when the microsensors based on protoporphyrin IX/Graphene-Au-3 and on MD/Graphene were employed in the platform design. Graphite 156-164 C-C motif chemokine ligand 2 Homo sapiens 50-55 25491674-13 2015 CONCLUSION: MMC treatment leads to elevated urinary CK levels with significantly higher MCP-1 and IL-6 levels in C-HT-treated patients. Mitomycin 12-15 C-C motif chemokine ligand 2 Homo sapiens 88-93 26314842-9 2015 Mechanistically, the variant-alleles of these two polymorphisms significantly decreased by 20-30% of CCL2/CCL5 (CDR ligands) levels relative to their major counterparts. cdr 112-115 C-C motif chemokine ligand 2 Homo sapiens 101-105 26400537-13 2015 CONCLUSIONS: Irbesartan attenuates TNFalpha-induced ICAM-1, VCAM-1 and MCP-1 expression through the suppression of NF-kappaB pathways. Irbesartan 13-23 C-C motif chemokine ligand 2 Homo sapiens 71-76 26327448-7 2015 TNF was most potent in myofibroblast cultures, suggesting ADT induces CCL2 via paracrine interactions within the tumor microenvironment. adt 58-61 C-C motif chemokine ligand 2 Homo sapiens 70-74 26327448-8 2015 A soluble TNF receptor (etanercept) blocked enzalutamide-induced CCL2 protein secretion and mRNA, implying dependence on secreted TNF. enzalutamide 44-56 C-C motif chemokine ligand 2 Homo sapiens 65-69 26327448-10 2015 Analysis of human prostate cancers suggests that a TNF-CCL2 paracrine loop is induced in response to ADT and might account for some forms of prostate cancer therapy resistance. adt 101-104 C-C motif chemokine ligand 2 Homo sapiens 55-59 26232645-10 2015 Administration of bilirubin reduced mean linear intercept and mean alveoli area, increased mean alveoli number, reduced macrophage, neutrophil and TNF-alpha content of BALF, and increased BALF and serum IL-10 level, but lowered local and systemic CCL2, CXCL2, CXCL8 and IL-17 levels. Bilirubin 18-27 C-C motif chemokine ligand 2 Homo sapiens 247-251 25986659-9 2015 Cinacalcet also elevated expression of the proinflammatory factors IL1beta, IL6 and CCL2. Cinacalcet 0-10 C-C motif chemokine ligand 2 Homo sapiens 84-88 26136104-6 2015 The results revealed that treatment with YCG063 significantly inhibited the levels of IL-6, IL-8, MCP-1 and ICAM-1 in the PA-LPS-stimulated ARPE-19 cells. YCG 063 41-47 C-C motif chemokine ligand 2 Homo sapiens 98-103 25977183-6 2015 Moreover, pretreatment of NHEKs with Z-lig reduced UVB-induced nuclear factor kappa B (NF-kappaB)-dependent inflammatory mediators (IL-6, IL-8 and MCP-1) production at both mRNA and protein level. ligustilide 37-42 C-C motif chemokine ligand 2 Homo sapiens 147-152 26136104-6 2015 The results revealed that treatment with YCG063 significantly inhibited the levels of IL-6, IL-8, MCP-1 and ICAM-1 in the PA-LPS-stimulated ARPE-19 cells. Protactinium 122-124 C-C motif chemokine ligand 2 Homo sapiens 98-103 25876063-5 2015 Osthole was able to suppress the levels of proinflammatory cytokines interleukin (IL)-1beta and IL-6, as well as chemokines monocyte chemoattractant protein-1 and IL-8. osthol 0-7 C-C motif chemokine ligand 2 Homo sapiens 124-158 26617775-4 2015 We observed in HK-2 cells that fenofibrate significantly inhibited fatty acids bound albumin (FA-BSA) induced up-regulation of MCP-1 and IL-8. Fenofibrate 31-42 C-C motif chemokine ligand 2 Homo sapiens 127-132 26617775-4 2015 We observed in HK-2 cells that fenofibrate significantly inhibited fatty acids bound albumin (FA-BSA) induced up-regulation of MCP-1 and IL-8. Fatty Acids 67-78 C-C motif chemokine ligand 2 Homo sapiens 127-132 25832610-9 2015 RESULTS: NW-21 suppressed osteoclast formation and activity as well as significantly reducing mRNA expression of MCP-1 and MIP-1alpha in monocytes stimulated by lipopolysaccharide or TNF-alpha (P < 0.05) in vitro. nw-21 9-14 C-C motif chemokine ligand 2 Homo sapiens 113-118 25572340-11 2015 However, rosiglitazone exhibited anti-inflammatory activity in human adipocytes by limiting MCP-1 expression. Rosiglitazone 9-22 C-C motif chemokine ligand 2 Homo sapiens 92-97 26233874-8 2015 SES corrected plasma level of monocyte chemoattractant protein-1 (P = 0.0380), which was increased by the HF diet. ses 0-3 C-C motif chemokine ligand 2 Homo sapiens 30-64 26054298-6 2015 Inhibition of the CCL2 receptor (CCR2) on THP-1 monocytes with RS102895, a specific CCR2 inhibitor, did not block migration induced by lipoapoptotic supernatants. RS 102895 63-71 C-C motif chemokine ligand 2 Homo sapiens 18-22 25901081-10 2015 In a zebrafish model, macrophages increased cancer cell dissemination via CCL2 and CCL5 in the presence of estradiol, which was inhibited with anti-CCL2 and anti-CCL5 treatment. Estradiol 107-116 C-C motif chemokine ligand 2 Homo sapiens 148-152 26085050-2 2015 In ACS, aspirin at antiplatelet doses exhibits anti-inflammatory effects as seen from the decrease in inflammation markers such as CRP, M-CSF, MCP-1 and others. Aspirin 8-15 C-C motif chemokine ligand 2 Homo sapiens 143-148 26294325-5 2015 Of the top 10 genes (fold-change > 10, P < 10(-10)) regulated by metformin plus aspirin, PCDH18, CCL2, RASL11A, FAM111B and BMP5 were down-regulated >= 20-fold, while NGFR, NPTX1, C7orf57, MRPL23AS1 and UNC5B were up-regulated >= 10-fold. Metformin 71-80 C-C motif chemokine ligand 2 Homo sapiens 103-107 26294325-5 2015 Of the top 10 genes (fold-change > 10, P < 10(-10)) regulated by metformin plus aspirin, PCDH18, CCL2, RASL11A, FAM111B and BMP5 were down-regulated >= 20-fold, while NGFR, NPTX1, C7orf57, MRPL23AS1 and UNC5B were up-regulated >= 10-fold. Aspirin 86-93 C-C motif chemokine ligand 2 Homo sapiens 103-107 26190093-4 2015 Resveratrol can both decrease the secretion of proinflammatory cytokines (e.g., IL-6, IL-8, and TNF-alpha) and increase the production of anti-inflammatory cytokines; it also decreases the expression of adhesion proteins (e.g., ICAM-1) and leukocyte chemoattractants (e.g., MCP-1). Resveratrol 0-11 C-C motif chemokine ligand 2 Homo sapiens 274-279 25845330-4 2015 Next, Au@Pt core-shell microspheres with large surface area were grafted onto the modified electrode to immobilize more MCP-1 antibodies. Gold 6-8 C-C motif chemokine ligand 2 Homo sapiens 120-125 25967348-7 2015 Consistent with histology results, EGCG treatment significantly inhibited MCD diet-induced IL-1beta, IL-6, TNF-alpha and MCP-1 mRNA expression. epigallocatechin gallate 35-39 C-C motif chemokine ligand 2 Homo sapiens 121-126 26246800-3 2015 Here, we analyze the influence of DMF on TNF-alpha-induced expression of the important pro-inflammatory and pro-atherogenic chemokine MCP-1 and investigate the underlying mechanisms of this expression. Dimethyl Fumarate 34-37 C-C motif chemokine ligand 2 Homo sapiens 134-139 26246800-4 2015 FINDINGS: We analyzed constitutive and TNF-alpha-induced expression of MCP-1 in human umbilical vascular endothelial cells (HUVEC) +/- DMF treatment via enzyme-linkes immunosorbent assay (ELISA). Dimethyl Fumarate 135-138 C-C motif chemokine ligand 2 Homo sapiens 71-76 26246800-6 2015 Furthermore, MCP-1 mRNA expression was also reduced in response to DMF, as demonstrated by RT-PCR. Dimethyl Fumarate 67-70 C-C motif chemokine ligand 2 Homo sapiens 13-18 26246800-8 2015 Interestingly, DMF prolonged the TNF-alpha-induced p38 and JNK phosphorylation in HUVEC, as demonstrated by Western blot analysis; however, the p38 and JNK inhibitor SB203580 did not affect the DMF-conveyed suppression of TNF-alpha-induced MCP-1 expression. Dimethyl Fumarate 15-18 C-C motif chemokine ligand 2 Homo sapiens 240-245 26093886-8 2015 Only in diabetic plaques, calcium content was inversely correlated with MCP1 and IL1b, whereas the direct correlation with TNF-alpha expression seen in non-diabetic plaques was lost in diabetes. Calcium 26-33 C-C motif chemokine ligand 2 Homo sapiens 72-76 25890876-6 2015 This inhibitory action of resveratrol was also observed for the cytokines-induced expression of chemokines CXCL9, CCL2 and CCL5. Resveratrol 26-37 C-C motif chemokine ligand 2 Homo sapiens 114-118 25154882-0 2015 Effect of prostaglandin I2 analogs on monocyte chemoattractant protein-1 in human monocyte and macrophage. Epoprostenol 10-26 C-C motif chemokine ligand 2 Homo sapiens 38-72 25154882-5 2015 However, little is known about the effect of PGI2 analogs on the MCP-1 production in human monocytes and macrophages. Epoprostenol 45-49 C-C motif chemokine ligand 2 Homo sapiens 65-70 25154882-6 2015 We investigated the effects of three conventional (iloprost, beraprost and treprostinil) and one new (ONO-1301) PGI2 analogs, on the expression of MCP-1 expression in human monocytes and macrophages. Iloprost 51-59 C-C motif chemokine ligand 2 Homo sapiens 147-152 25154882-6 2015 We investigated the effects of three conventional (iloprost, beraprost and treprostinil) and one new (ONO-1301) PGI2 analogs, on the expression of MCP-1 expression in human monocytes and macrophages. beraprost 61-70 C-C motif chemokine ligand 2 Homo sapiens 147-152 25154882-6 2015 We investigated the effects of three conventional (iloprost, beraprost and treprostinil) and one new (ONO-1301) PGI2 analogs, on the expression of MCP-1 expression in human monocytes and macrophages. treprostinil 75-87 C-C motif chemokine ligand 2 Homo sapiens 147-152 25154882-6 2015 We investigated the effects of three conventional (iloprost, beraprost and treprostinil) and one new (ONO-1301) PGI2 analogs, on the expression of MCP-1 expression in human monocytes and macrophages. ONO 1301 102-110 C-C motif chemokine ligand 2 Homo sapiens 147-152 25154882-6 2015 We investigated the effects of three conventional (iloprost, beraprost and treprostinil) and one new (ONO-1301) PGI2 analogs, on the expression of MCP-1 expression in human monocytes and macrophages. Epoprostenol 112-116 C-C motif chemokine ligand 2 Homo sapiens 147-152 25154882-9 2015 To explore which receptors involved the effects of PGI2 analogs on the expression of MCP-1 expression, IP and EP, PPAR-alpha and PPAR-gamma receptor antagonists were used. Epoprostenol 51-55 C-C motif chemokine ligand 2 Homo sapiens 85-90 25154882-10 2015 Forskolin, a cAMP activator, was used to further confirm the involvement of cAMP on MCP-1 production in human monocytes. Colforsin 0-9 C-C motif chemokine ligand 2 Homo sapiens 84-89 25154882-10 2015 Forskolin, a cAMP activator, was used to further confirm the involvement of cAMP on MCP-1 production in human monocytes. Cyclic AMP 76-80 C-C motif chemokine ligand 2 Homo sapiens 84-89 25154882-16 2015 PGI2 analogs suppressed LPS-induced MCP-1 production in human monocytes and macrophages via the IP receptor and cAMP pathway. Epoprostenol 0-4 C-C motif chemokine ligand 2 Homo sapiens 36-41 25154882-16 2015 PGI2 analogs suppressed LPS-induced MCP-1 production in human monocytes and macrophages via the IP receptor and cAMP pathway. Cyclic AMP 112-116 C-C motif chemokine ligand 2 Homo sapiens 36-41 26083329-10 2015 CONCLUSIONS: Our data indicates a correlation between the MCP-1 A-2518G polymorphism with macrovascular complications in T2DM patients; lower BMI and FC, as well as higher HDL-C levels may be the protective factors for T2DM, while higher levels of TG, LDL-C, and G/G genotype frequency were independent risk factors for T2DM. Triglycerides 248-250 C-C motif chemokine ligand 2 Homo sapiens 58-63 26113681-7 2015 C-reactive protein (CRP), interleukin-10, monocyte chemotactic protein-1, macrophage inflammatory protein-1alpha and matrix metalloproteinase (MMP)-9 were significantly elevated in CTEPH patients. cteph 181-186 C-C motif chemokine ligand 2 Homo sapiens 42-72 25857968-2 2015 We demonstrated that CPS-F not only inhibits platelet-derived growth factor BB (PDGF-BB)-induced intracellular reactive oxygen species (ROS) generation, and up-regulation of tumor necrosis factor-alpha (TNF-alpha), TNF-alpha receptor 1 (TNFR1), and monocyte chemotactic protein-1 (MCP-1), but also acts synergistically in combination with MAPK/ERK inhibitor U0126 and PI3K/Akt inhibitor LY294002. Chlorpyrifos 21-26 C-C motif chemokine ligand 2 Homo sapiens 249-279 26244291-6 2015 Sorafenib significantly inhibited production of TGF-beta1, VEGF, IL-6, IL-8, MCP-1, and TNF-alpha and blocked the activation of migration-related signaling molecules, such as HIF-1alpha, p-STAT3, MMP2, and Ang-1. Sorafenib 0-9 C-C motif chemokine ligand 2 Homo sapiens 77-82 26003810-5 2015 CCL2 was also down-regulated by luteotrophic prostaglandin (PG) E (P < 0.0001), but up-regulated by luteolytic PGF (P < 0.05) in vitro. Prostaglandins E 45-65 C-C motif chemokine ligand 2 Homo sapiens 0-4 26003810-5 2015 CCL2 was also down-regulated by luteotrophic prostaglandin (PG) E (P < 0.0001), but up-regulated by luteolytic PGF (P < 0.05) in vitro. Prostaglandins F 114-117 C-C motif chemokine ligand 2 Homo sapiens 0-4 26003810-8 2015 CCL2 mRNA expression was negatively correlated with both HSD3B1 and PGES, suggesting that locally produced progesterone and PGE suppress macrophage infiltration into the CL. Progesterone 107-119 C-C motif chemokine ligand 2 Homo sapiens 0-4 26003810-8 2015 CCL2 mRNA expression was negatively correlated with both HSD3B1 and PGES, suggesting that locally produced progesterone and PGE suppress macrophage infiltration into the CL. Prostaglandins E 68-71 C-C motif chemokine ligand 2 Homo sapiens 0-4 25962642-9 2015 Within 2-4 h, Ag increased superoxide anion release and stimulated cytokine production (MCP-1, IL-8) that was diminished by Ca2+ inhibitors or trolox. 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid 143-149 C-C motif chemokine ligand 2 Homo sapiens 88-93 26222138-7 2015 In addition, PMA-inducible secretion of monocyte chemotactic protein 1 (MCP-1) was significantly high in NRF2-silenced U937. Tetradecanoylphorbol Acetate 13-16 C-C motif chemokine ligand 2 Homo sapiens 40-70 26222138-7 2015 In addition, PMA-inducible secretion of monocyte chemotactic protein 1 (MCP-1) was significantly high in NRF2-silenced U937. Tetradecanoylphorbol Acetate 13-16 C-C motif chemokine ligand 2 Homo sapiens 72-77 26251624-8 2015 Sitagliptin therapy for 3 and 6 months significantly reduced plasma levels of sP-selectin, sE-selectin, sVCAM-1, and MCP-1 relative to baseline, while significantly increasing adiponectin levels. Sitagliptin Phosphate 0-11 C-C motif chemokine ligand 2 Homo sapiens 117-122 26251624-10 2015 Furthermore, the reductions in sP-selectin, sE-selectin, sVCAM-1, and MCP-1 during sitagliptin therapy were significantly greater in responders, defined as patients with a significant increase in adiponectin levels, than in nonresponders. Sitagliptin Phosphate 83-94 C-C motif chemokine ligand 2 Homo sapiens 70-75 25857968-4 2015 Furthermore, CPS-F prevents the PDGF receptor beta (PDGFRbeta) promoter activity induced by PDGF-BB in transfected cells and ameliorates increased levels of TNF-alpha, TNFR1, and MCP-1 when PDGFRbeta is silenced, thereby suggesting that CPS-F possesses a bidirectional regulatory function. Chlorpyrifos 13-18 C-C motif chemokine ligand 2 Homo sapiens 179-184 25981678-6 2015 Cholesterol cholic acid diet induced an increased monocyte to macrophage differentiation by upregulating MCP1 and VCAM1 which induced the inflammatory cytokines that further substantiated the monocyte conversion and infiltration into the vascular walls. cholesterol cholic acid 0-23 C-C motif chemokine ligand 2 Homo sapiens 105-109 26006043-0 2015 Suppression of methylmercury-induced IL-6 and MCP-1 expressions by N-acetylcysteine in U-87MG human astrocytoma cells. Acetylcysteine 67-83 C-C motif chemokine ligand 2 Homo sapiens 46-51 26006043-7 2015 MeHg-induced expression of MCP-1 and IL-6 mRNA was reduced by 10-20% in the presence of 5mM NAC (co-treatment experiment) compared to cells treated with MeHg only. Acetylcysteine 92-95 C-C motif chemokine ligand 2 Homo sapiens 27-32 26006043-8 2015 Pre-treatment of cells with 0.5 or 5mM NAC at 0.5 or 1h and its subsequent washout before MeHg addition suppressed MCP-1 and IL-6 cytokine expressions. Acetylcysteine 39-42 C-C motif chemokine ligand 2 Homo sapiens 115-120 26006043-8 2015 Pre-treatment of cells with 0.5 or 5mM NAC at 0.5 or 1h and its subsequent washout before MeHg addition suppressed MCP-1 and IL-6 cytokine expressions. Hydrogen 53-55 C-C motif chemokine ligand 2 Homo sapiens 115-120 26038194-7 2015 Chemokines, RANTES/CCL5, MCP-1/CCL2, and related molecules, constitute the C-C class of chemokine supergene family, play a role in regulating T helper-cell cytokine production and MC trafficking, and are involved in histamine and serotonin generation and MC functions. Histamine 216-225 C-C motif chemokine ligand 2 Homo sapiens 25-31 26038194-7 2015 Chemokines, RANTES/CCL5, MCP-1/CCL2, and related molecules, constitute the C-C class of chemokine supergene family, play a role in regulating T helper-cell cytokine production and MC trafficking, and are involved in histamine and serotonin generation and MC functions. Histamine 216-225 C-C motif chemokine ligand 2 Homo sapiens 31-35 26038194-7 2015 Chemokines, RANTES/CCL5, MCP-1/CCL2, and related molecules, constitute the C-C class of chemokine supergene family, play a role in regulating T helper-cell cytokine production and MC trafficking, and are involved in histamine and serotonin generation and MC functions. Serotonin 230-239 C-C motif chemokine ligand 2 Homo sapiens 25-31 26038194-7 2015 Chemokines, RANTES/CCL5, MCP-1/CCL2, and related molecules, constitute the C-C class of chemokine supergene family, play a role in regulating T helper-cell cytokine production and MC trafficking, and are involved in histamine and serotonin generation and MC functions. Serotonin 230-239 C-C motif chemokine ligand 2 Homo sapiens 31-35 25857968-2 2015 We demonstrated that CPS-F not only inhibits platelet-derived growth factor BB (PDGF-BB)-induced intracellular reactive oxygen species (ROS) generation, and up-regulation of tumor necrosis factor-alpha (TNF-alpha), TNF-alpha receptor 1 (TNFR1), and monocyte chemotactic protein-1 (MCP-1), but also acts synergistically in combination with MAPK/ERK inhibitor U0126 and PI3K/Akt inhibitor LY294002. Chlorpyrifos 21-26 C-C motif chemokine ligand 2 Homo sapiens 281-286 26138903-8 2015 Honokiol showed an anti-inflammatory effect in PA-inducted HUVECs by significantly inhibiting the generation of interleukin-6 (IL-6), IL-8 and monocyte chemoattractant protein-1. honokiol 0-8 C-C motif chemokine ligand 2 Homo sapiens 143-177 26151816-12 2015 CONCLUSIONS: Alcohol consumption affects the immune phenotype of CD8 cells since binge drinking pattern was found to be associated with high CD69 and low TLR4, CXCR4 and CCR2 expression, which suggest recent activation, decreased sensitivity to LPS and lower migration capacity in response to chemokines SDF-1 and MCP-1. Alcohols 13-20 C-C motif chemokine ligand 2 Homo sapiens 314-319 26138903-8 2015 Honokiol showed an anti-inflammatory effect in PA-inducted HUVECs by significantly inhibiting the generation of interleukin-6 (IL-6), IL-8 and monocyte chemoattractant protein-1. Palmitic Acid 47-49 C-C motif chemokine ligand 2 Homo sapiens 143-177 25626738-9 2015 Lower levels of MCP-1 and IL-8 (P < 0.001) and higher levels of IL-6 and MMP-9 (P = 0.003) were found in the sevoflurane group, compared with the TIVA group 30 min post-operatively. Sevoflurane 112-123 C-C motif chemokine ligand 2 Homo sapiens 16-21 24854157-6 2015 Interleukin-1 beta (IL-1beta), chemokine (C-X3-C motif) ligand 1 (CX3CL1)/fractalkine and CXCL12/SDF-1 positively correlated with the cocaine symptom severity when using the DSM-IV-TR criteria for cocaine abuse/dependence. Cocaine 134-141 C-C motif chemokine ligand 2 Homo sapiens 31-41 26124338-10 2015 An increase of MCP1 level or its addition to cisplatin, docetaxel and cilengitide reduce colony formation but the efficacy of temsirolimus is augmented by MCP1 depletion. Docetaxel 56-65 C-C motif chemokine ligand 2 Homo sapiens 15-19 26124338-7 2015 Addition of MCP1 to cisplatin, docetaxel and cilengitide increased efficacy of cytostatics in inhibition of colony formation, whereas those with temsirolimus were increased by anti-MCP1 that when applied alone failed to modulate colony formation. Cisplatin 20-29 C-C motif chemokine ligand 2 Homo sapiens 12-16 26124338-10 2015 An increase of MCP1 level or its addition to cisplatin, docetaxel and cilengitide reduce colony formation but the efficacy of temsirolimus is augmented by MCP1 depletion. temsirolimus 126-138 C-C motif chemokine ligand 2 Homo sapiens 15-19 26124338-7 2015 Addition of MCP1 to cisplatin, docetaxel and cilengitide increased efficacy of cytostatics in inhibition of colony formation, whereas those with temsirolimus were increased by anti-MCP1 that when applied alone failed to modulate colony formation. Docetaxel 31-40 C-C motif chemokine ligand 2 Homo sapiens 12-16 26124338-10 2015 An increase of MCP1 level or its addition to cisplatin, docetaxel and cilengitide reduce colony formation but the efficacy of temsirolimus is augmented by MCP1 depletion. temsirolimus 126-138 C-C motif chemokine ligand 2 Homo sapiens 155-159 25631486-8 2015 Among the vitrectomised patients, the mean vitreous level of MCP-1 in eyes with diabetic macular oedema (DME) was significantly higher than in those without DME (p=0.028). dme 105-108 C-C motif chemokine ligand 2 Homo sapiens 61-66 25631486-8 2015 Among the vitrectomised patients, the mean vitreous level of MCP-1 in eyes with diabetic macular oedema (DME) was significantly higher than in those without DME (p=0.028). dme 157-160 C-C motif chemokine ligand 2 Homo sapiens 61-66 25631486-9 2015 CONCLUSIONS: The elevated levels of MCP-1 and IL-6 may indicate prolonged inflammation even after successful vitrectomy, which can cause postoperative DME. dme 151-154 C-C motif chemokine ligand 2 Homo sapiens 36-41 25801692-6 2015 However, overall significant decreases in MCP-1, PAI-1, MMP-9, IL-18 and IL-6, and increases in adropin and osteocrin plasma concentrations occurred after T&A. t& 155-160 C-C motif chemokine ligand 2 Homo sapiens 42-47 25958099-9 2015 TGF-beta1 and E-selectin concentrations increased while MCP-1 decreased across quartiles of fasting plasma glucose. Glucose 107-114 C-C motif chemokine ligand 2 Homo sapiens 56-61 25545021-6 2015 Inhibition of KCa3.1 by the selective, pore-blocking inhibitor TRAM-34, (and, in part, by siRNA) significantly reduced cell proliferation, as well as expression and secretion of pro-inflammatory factors (IL-6, IL-8, and MCP1) and the tissue-destructive protease MMP3. TRAM 34 63-70 C-C motif chemokine ligand 2 Homo sapiens 220-224 25738314-7 2015 Furthermore, the data suggested that the functions of miR-125b in arteriosclerosis obliterans may be associated with transgelin, lectin-type oxidized LDL receptor-1, vascular endothelial-cadherin, intercellular adhesion molecule-1, interleukin-6 and monocyte chemotactic protein-1. mir-125b 54-62 C-C motif chemokine ligand 2 Homo sapiens 250-280 25727025-8 2015 Positive significant correlations were detected between serum neopterin and ESR, TNF-alpha, IL-6, MCP-1, and JADAS-27 (p<0.05). Neopterin 62-71 C-C motif chemokine ligand 2 Homo sapiens 98-103 25738264-0 2015 Testosterone enhances lipopolysaccharide-induced interleukin-6 and macrophage chemotactic protein-1 expression by activating the extracellular signal-regulated kinase 1/2/nuclear factor-kappaB signalling pathways in 3T3-L1 adipocytes. Testosterone 0-12 C-C motif chemokine ligand 2 Homo sapiens 67-99 25938165-3 2015 We used a database of glycan array data to identify the lectins CCL2 to detect glycan motifs with fucose in a 3" linkage; CGL2 for motifs with fucose in a 2" linkage; and RSL for fucose in all linkages. Polysaccharides 22-28 C-C motif chemokine ligand 2 Homo sapiens 64-68 25738264-7 2015 Testosterone induces IL-6 and MCP-1, and enhances LPS-induction of IL-6 and MCP-1. Testosterone 0-12 C-C motif chemokine ligand 2 Homo sapiens 30-35 25738264-7 2015 Testosterone induces IL-6 and MCP-1, and enhances LPS-induction of IL-6 and MCP-1. Testosterone 0-12 C-C motif chemokine ligand 2 Homo sapiens 76-81 25738264-10 2015 The effect of testosterone on the expression of IL-6 and MCP-1 is inhibited by PD98059 , an ERK1/2 inhibitor, and PDTC, an NF-kappaB inhibitor. Testosterone 14-26 C-C motif chemokine ligand 2 Homo sapiens 57-62 25738264-10 2015 The effect of testosterone on the expression of IL-6 and MCP-1 is inhibited by PD98059 , an ERK1/2 inhibitor, and PDTC, an NF-kappaB inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 79-86 C-C motif chemokine ligand 2 Homo sapiens 57-62 25738264-11 2015 The results indicate that testosterone enhances LPS-induced IL-6 and MCP-1 expression by activating the ERK1/2/NF-kappaB signalling pathways in 3T3-L1 adipocytes. Testosterone 26-38 C-C motif chemokine ligand 2 Homo sapiens 69-74 26110640-14 2015 Dh404 significantly decreased production of cytokines/chemokines including IL-1beta, IL-6, IFN-gamma and MCP-1. dh404 0-5 C-C motif chemokine ligand 2 Homo sapiens 105-110 25882540-4 2015 Confirmatory enzyme-linked immunosorbent assays (ELISAs) showed that PGF2alpha stimulated increased output of interleukin (IL) 1beta, IL6, IL8 (CXCL8) and monocyte chemotactic protein-1 (MCP1, also known as chemokine (c-c motif) ligand 2, CCL2) by HUSMCs isolated from both upper and lower uterine segments. Dinoprost 69-78 C-C motif chemokine ligand 2 Homo sapiens 155-185 25882540-4 2015 Confirmatory enzyme-linked immunosorbent assays (ELISAs) showed that PGF2alpha stimulated increased output of interleukin (IL) 1beta, IL6, IL8 (CXCL8) and monocyte chemotactic protein-1 (MCP1, also known as chemokine (c-c motif) ligand 2, CCL2) by HUSMCs isolated from both upper and lower uterine segments. Dinoprost 69-78 C-C motif chemokine ligand 2 Homo sapiens 187-191 25882540-4 2015 Confirmatory enzyme-linked immunosorbent assays (ELISAs) showed that PGF2alpha stimulated increased output of interleukin (IL) 1beta, IL6, IL8 (CXCL8) and monocyte chemotactic protein-1 (MCP1, also known as chemokine (c-c motif) ligand 2, CCL2) by HUSMCs isolated from both upper and lower uterine segments. Dinoprost 69-78 C-C motif chemokine ligand 2 Homo sapiens 207-237 25882540-4 2015 Confirmatory enzyme-linked immunosorbent assays (ELISAs) showed that PGF2alpha stimulated increased output of interleukin (IL) 1beta, IL6, IL8 (CXCL8) and monocyte chemotactic protein-1 (MCP1, also known as chemokine (c-c motif) ligand 2, CCL2) by HUSMCs isolated from both upper and lower uterine segments. Dinoprost 69-78 C-C motif chemokine ligand 2 Homo sapiens 239-243 25882540-10 2015 Inhibition of ERK reversed PGF2alpha-induced IL1beta, IL6 and CCL2 output, while inhibition of PI3K blocked the effect of PGF2alpha on IL6, CXCL8 and CCL2 output and inhibition of NF-kappaB reversed PGF2alpha-induced IL1beta and CCL2 output. Dinoprost 27-36 C-C motif chemokine ligand 2 Homo sapiens 62-66 25882540-10 2015 Inhibition of ERK reversed PGF2alpha-induced IL1beta, IL6 and CCL2 output, while inhibition of PI3K blocked the effect of PGF2alpha on IL6, CXCL8 and CCL2 output and inhibition of NF-kappaB reversed PGF2alpha-induced IL1beta and CCL2 output. Dinoprost 122-131 C-C motif chemokine ligand 2 Homo sapiens 150-154 25882540-10 2015 Inhibition of ERK reversed PGF2alpha-induced IL1beta, IL6 and CCL2 output, while inhibition of PI3K blocked the effect of PGF2alpha on IL6, CXCL8 and CCL2 output and inhibition of NF-kappaB reversed PGF2alpha-induced IL1beta and CCL2 output. Dinoprost 122-131 C-C motif chemokine ligand 2 Homo sapiens 150-154 25882540-10 2015 Inhibition of ERK reversed PGF2alpha-induced IL1beta, IL6 and CCL2 output, while inhibition of PI3K blocked the effect of PGF2alpha on IL6, CXCL8 and CCL2 output and inhibition of NF-kappaB reversed PGF2alpha-induced IL1beta and CCL2 output. Dinoprost 122-131 C-C motif chemokine ligand 2 Homo sapiens 150-154 25882540-10 2015 Inhibition of ERK reversed PGF2alpha-induced IL1beta, IL6 and CCL2 output, while inhibition of PI3K blocked the effect of PGF2alpha on IL6, CXCL8 and CCL2 output and inhibition of NF-kappaB reversed PGF2alpha-induced IL1beta and CCL2 output. Dinoprost 122-131 C-C motif chemokine ligand 2 Homo sapiens 150-154 25882540-11 2015 NFAT was involved in PGF2alpha modulation of CCL2 and TNFalpha output. Dinoprost 21-30 C-C motif chemokine ligand 2 Homo sapiens 45-49 26052894-6 2015 In addition to increased expression of downstream signaling mediators RIPK2 and NF-kappaB p65 nuclear translocation, there was remarkably higher release of monocyte chemotactic protein1 (MCP-1), interleukin (IL)-6, and IL-8 in MetS versus controls following priming of the isolated adipocytes with NOD1 ligand iE-DAP. alpha,beta-diacryloxypropionic acid 313-316 C-C motif chemokine ligand 2 Homo sapiens 156-185 25924055-8 2015 In addition, :CCl3(-)* can be nonreductively dechlorinated to form :CCl2* followed by sequential nucleophilic attack by OH(-)*, resulting in the formation of :CCl(OH)* and :C(OH)2*, which are responsible for production of CO and formate, respectively. Cefaclor 14-17 C-C motif chemokine ligand 2 Homo sapiens 68-72 25924055-8 2015 In addition, :CCl3(-)* can be nonreductively dechlorinated to form :CCl2* followed by sequential nucleophilic attack by OH(-)*, resulting in the formation of :CCl(OH)* and :C(OH)2*, which are responsible for production of CO and formate, respectively. Carbon Monoxide 222-224 C-C motif chemokine ligand 2 Homo sapiens 68-72 25924055-8 2015 In addition, :CCl3(-)* can be nonreductively dechlorinated to form :CCl2* followed by sequential nucleophilic attack by OH(-)*, resulting in the formation of :CCl(OH)* and :C(OH)2*, which are responsible for production of CO and formate, respectively. formic acid 229-236 C-C motif chemokine ligand 2 Homo sapiens 68-72 25938165-3 2015 We used a database of glycan array data to identify the lectins CCL2 to detect glycan motifs with fucose in a 3" linkage; CGL2 for motifs with fucose in a 2" linkage; and RSL for fucose in all linkages. Polysaccharides 79-85 C-C motif chemokine ligand 2 Homo sapiens 64-68 25938165-3 2015 We used a database of glycan array data to identify the lectins CCL2 to detect glycan motifs with fucose in a 3" linkage; CGL2 for motifs with fucose in a 2" linkage; and RSL for fucose in all linkages. Fucose 98-104 C-C motif chemokine ligand 2 Homo sapiens 64-68 25819434-10 2015 Finally, trophoblast cells treated with Neo increased the expression of two antigen-presenting cells attracting chemokines, MCP-1, MIP-1alpha and RANTES through muscarinic receptors, and it was prevented by atropine. Neostigmine 40-43 C-C motif chemokine ligand 2 Homo sapiens 124-129 26040555-12 2015 In addition, anti-dsDNA antibodies also significantly increased the activation of NF-kappaB and upregulated the expression of IL-1beta, TNF-alpha and MCP-1, which were suppressed by pretreatment of HMCs with chemical ER stress inhibitor 4-PBA. 4-phenylbutylamine 237-242 C-C motif chemokine ligand 2 Homo sapiens 150-155 25819434-10 2015 Finally, trophoblast cells treated with Neo increased the expression of two antigen-presenting cells attracting chemokines, MCP-1, MIP-1alpha and RANTES through muscarinic receptors, and it was prevented by atropine. Atropine 207-215 C-C motif chemokine ligand 2 Homo sapiens 124-129 25834072-7 2015 CCL2 mRNA expression was upregulated by high concentrations of glucose after 6 h, but, most notably, a concentration-dependent induction of CCL2 was present after 96 h. In human peritoneal biopsies, NFAT5 mRNA levels were increased in uremic patients compared with nonuremic control patients. Glucose 63-70 C-C motif chemokine ligand 2 Homo sapiens 0-4 25882815-7 2015 High glucose increased TGF-beta1 mRNA expression, which significantly increased migration inhibitory factor and monocyte chemoattractant protein-1 protein secretion. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 112-146 25398374-9 2015 Tofacitinib treatment significantly reduced synovial mRNA expression of matrix metalloproteinase (MMP)-1 and MMP-3 (p<0.05) and chemokines CCL2, CXCL10 and CXCL13 (p<0.05). tofacitinib 0-11 C-C motif chemokine ligand 2 Homo sapiens 142-146 25340263-6 2015 Ten nmol/l 17beta-estradiol increased RAGE and monocyte chemoattractant protein-1 (MCP-1) gene and protein expression in human umbilical vein endothelial cells (HUVECs), both of which were blocked by 10 nmol/l bazedoxifene. Estradiol 11-27 C-C motif chemokine ligand 2 Homo sapiens 47-81 25340263-6 2015 Ten nmol/l 17beta-estradiol increased RAGE and monocyte chemoattractant protein-1 (MCP-1) gene and protein expression in human umbilical vein endothelial cells (HUVECs), both of which were blocked by 10 nmol/l bazedoxifene. Estradiol 11-27 C-C motif chemokine ligand 2 Homo sapiens 83-88 25340263-6 2015 Ten nmol/l 17beta-estradiol increased RAGE and monocyte chemoattractant protein-1 (MCP-1) gene and protein expression in human umbilical vein endothelial cells (HUVECs), both of which were blocked by 10 nmol/l bazedoxifene. bazedoxifene 210-222 C-C motif chemokine ligand 2 Homo sapiens 47-81 25340263-6 2015 Ten nmol/l 17beta-estradiol increased RAGE and monocyte chemoattractant protein-1 (MCP-1) gene and protein expression in human umbilical vein endothelial cells (HUVECs), both of which were blocked by 10 nmol/l bazedoxifene. bazedoxifene 210-222 C-C motif chemokine ligand 2 Homo sapiens 83-88 25340263-7 2015 Bazedoxifene at 10 nmol/l also significantly inhibited the AGEs-induced superoxide generation, RAGE and MCP-1 gene and protein expression in HUVECs. bazedoxifene 0-12 C-C motif chemokine ligand 2 Homo sapiens 104-109 25817234-0 2015 Puerarin suppresses high glucose-induced MCP-1 expression via modulating histone methylation in cultured endothelial cells. puerarin 0-8 C-C motif chemokine ligand 2 Homo sapiens 41-46 25996641-4 2015 Phloretin inhibited levels of prostaglandin E2, decreased COX-2 expression, and suppressed IL-8, monocyte chemotactic protein 1, and IL-6 production. Phloretin 0-9 C-C motif chemokine ligand 2 Homo sapiens 97-127 25715050-5 2015 rIFI16 caused dose/time-dependent upregulation of IL-6, IL-8, CCL2, CCL5, CCL20, ICAM1, VCAM1, and TLR4, while secretion of IL-6 and IL-8 was amplified with lipopolysaccharide synergy. rifi16 0-6 C-C motif chemokine ligand 2 Homo sapiens 62-66 25817234-0 2015 Puerarin suppresses high glucose-induced MCP-1 expression via modulating histone methylation in cultured endothelial cells. Glucose 25-32 C-C motif chemokine ligand 2 Homo sapiens 41-46 25817234-2 2015 The purpose of the present study was to investigate the epigenetic mechanism involved in the repression of monocyte chemoattractant protein-1 (MCP-1) expression by puerarin under high glucose (25mM) condition. puerarin 164-172 C-C motif chemokine ligand 2 Homo sapiens 107-141 25817234-2 2015 The purpose of the present study was to investigate the epigenetic mechanism involved in the repression of monocyte chemoattractant protein-1 (MCP-1) expression by puerarin under high glucose (25mM) condition. puerarin 164-172 C-C motif chemokine ligand 2 Homo sapiens 143-148 25817234-2 2015 The purpose of the present study was to investigate the epigenetic mechanism involved in the repression of monocyte chemoattractant protein-1 (MCP-1) expression by puerarin under high glucose (25mM) condition. Glucose 184-191 C-C motif chemokine ligand 2 Homo sapiens 107-141 25817234-2 2015 The purpose of the present study was to investigate the epigenetic mechanism involved in the repression of monocyte chemoattractant protein-1 (MCP-1) expression by puerarin under high glucose (25mM) condition. Glucose 184-191 C-C motif chemokine ligand 2 Homo sapiens 143-148 25817234-3 2015 MAIN METHODS: MCP-1 gene expression was measured by Real-Time quantitative Polymerase Chain Reaction (RT-qPCR), the histone 3 lysine 4 methylation (H3K4me) and lysine 9 methylation (H3K9me) were evaluated using chromatin immunoprecipitation assay. Lysine 160-166 C-C motif chemokine ligand 2 Homo sapiens 14-19 25817234-4 2015 KEY FINDINGS: Puerarin significantly inhibited high glucose-induced upregulation of H3K4 di- and tri-methylation (H3K4me2/3) on the MCP-1 gene promotor. puerarin 14-22 C-C motif chemokine ligand 2 Homo sapiens 132-137 25672286-7 2015 Furthermore, the expression levels of chemokine (C-C motif) ligand (CCL)2, cyclooxygenase (COX)-2 and prostaglandin E2 (PGE2) were increased in the Transwell system and the inhibition of COX-2, but not CCL2, significantly decreased the polarization of the M2 macrophages. Dinoprostone 102-118 C-C motif chemokine ligand 2 Homo sapiens 202-206 25817234-4 2015 KEY FINDINGS: Puerarin significantly inhibited high glucose-induced upregulation of H3K4 di- and tri-methylation (H3K4me2/3) on the MCP-1 gene promotor. Glucose 52-59 C-C motif chemokine ligand 2 Homo sapiens 132-137 25672286-7 2015 Furthermore, the expression levels of chemokine (C-C motif) ligand (CCL)2, cyclooxygenase (COX)-2 and prostaglandin E2 (PGE2) were increased in the Transwell system and the inhibition of COX-2, but not CCL2, significantly decreased the polarization of the M2 macrophages. Dinoprostone 120-124 C-C motif chemokine ligand 2 Homo sapiens 202-206 25817234-5 2015 Additionally, the enrichment of H3K4 histone methyltransferases including MLL, menin and SET7 on the MCP-1 promotor was increased, while the demethylase LSD1 was decreased in EA.hy926 cells following exposure to high glucose. Glucose 217-224 C-C motif chemokine ligand 2 Homo sapiens 101-106 25817234-8 2015 SIGNIFICANCE: Our findings suggested that puerarin plays a critical role in transcriptional repression of high glucose-induced MCP-1 gene expression, at least in part due to alteration of H3K4me2/3 methylation, thus possesses a therapeutic potential in diabetes-induced vascular injuries. puerarin 42-50 C-C motif chemokine ligand 2 Homo sapiens 127-132 25817234-8 2015 SIGNIFICANCE: Our findings suggested that puerarin plays a critical role in transcriptional repression of high glucose-induced MCP-1 gene expression, at least in part due to alteration of H3K4me2/3 methylation, thus possesses a therapeutic potential in diabetes-induced vascular injuries. Glucose 111-118 C-C motif chemokine ligand 2 Homo sapiens 127-132 25622053-6 2015 RESULTS: Increases in plasma or CSF MCP-1 were associated with lower NAA/Cr in the MFC and BG, whereas metabolite changes in the frontal white matter for NAA/Cr, GlxCr, and Cho/Cr were explained almost exclusively by a single factor, sCD14. N-acetylaspartate 69-72 C-C motif chemokine ligand 2 Homo sapiens 36-41 26020416-0 2015 L-cystathionine inhibits oxidized low density lipoprotein-induced THP-1-derived macrophage inflammatory cytokine monocyte chemoattractant protein-1 generation via the NF-kappaB pathway. Cystathionine 0-15 C-C motif chemokine ligand 2 Homo sapiens 113-147 26020416-5 2015 Compared with the ox-LDL group, 0.3 mmol/L and 1.0 mmol/L L-cystathionine significantly inhibited the expression of THP-1-derived macrophage MCP-1. Cystathionine 58-73 C-C motif chemokine ligand 2 Homo sapiens 141-146 26020416-6 2015 Mechanistically, 0.3 mmol/L and 1.0 mmol/L L-cystathionine suppressed phosphorylation and nuclear translocation of the NF-kappaB p65 protein, as well as the DNA binding activity and DNA binding level of NF-kappaB with the MCP-1 promoter, which resulted in a reduced THP-1-derived macrophage MCP-1 generation. Cystathionine 43-58 C-C motif chemokine ligand 2 Homo sapiens 222-227 26020416-6 2015 Mechanistically, 0.3 mmol/L and 1.0 mmol/L L-cystathionine suppressed phosphorylation and nuclear translocation of the NF-kappaB p65 protein, as well as the DNA binding activity and DNA binding level of NF-kappaB with the MCP-1 promoter, which resulted in a reduced THP-1-derived macrophage MCP-1 generation. Cystathionine 43-58 C-C motif chemokine ligand 2 Homo sapiens 291-296 26020416-7 2015 This study suggests that L-cystathionine could inhibit the expression of MCP-1 in THP-1-derived macrophages induced by ox-LDL via inhibition of NF-kappaB p65 phosphorylation, nuclear translocation, and binding of the MCP-1 promoter sequence after entry into the nucleus. Cystathionine 25-40 C-C motif chemokine ligand 2 Homo sapiens 73-78 26020416-7 2015 This study suggests that L-cystathionine could inhibit the expression of MCP-1 in THP-1-derived macrophages induced by ox-LDL via inhibition of NF-kappaB p65 phosphorylation, nuclear translocation, and binding of the MCP-1 promoter sequence after entry into the nucleus. Cystathionine 25-40 C-C motif chemokine ligand 2 Homo sapiens 217-222 25813285-9 2015 Unfractionated heparin and LMWHs attenuated the TNF-alpha-mediated induction of CXCL8 and enhanced CXCL5, CCL2, and CCL5. Heparin 15-22 C-C motif chemokine ligand 2 Homo sapiens 106-110 25813285-9 2015 Unfractionated heparin and LMWHs attenuated the TNF-alpha-mediated induction of CXCL8 and enhanced CXCL5, CCL2, and CCL5. Heparin, Low-Molecular-Weight 27-32 C-C motif chemokine ligand 2 Homo sapiens 106-110 25622053-6 2015 RESULTS: Increases in plasma or CSF MCP-1 were associated with lower NAA/Cr in the MFC and BG, whereas metabolite changes in the frontal white matter for NAA/Cr, GlxCr, and Cho/Cr were explained almost exclusively by a single factor, sCD14. Creatine 73-75 C-C motif chemokine ligand 2 Homo sapiens 36-41 25567426-0 2015 CRF-amplified neuronal TLR4/MCP-1 signaling regulates alcohol self-administration. Alcohols 54-61 C-C motif chemokine ligand 2 Homo sapiens 28-33 25418357-13 2015 In these patients, serum levels of MCP1, but not routine biomarkers of bone turnover, including C-terminal cross-linking telopeptide of type-1 collagen (beta-CTx), positively correlated with their bone loss. beta-ctx 153-161 C-C motif chemokine ligand 2 Homo sapiens 35-39 25546398-9 2015 Macrophages exposed to GL-CM presented decreased ATP and AMP hydrolysis and increased IL-10 and MCP-1 secretion, effects that were diminished by P1 or P2 antagonists. glycylleucine 23-25 C-C motif chemokine ligand 2 Homo sapiens 96-101 25546398-11 2015 In summary, we found that A2A and P2X7 activation is necessary for IL-10, MCP-1, and IL-6 release by macrophages exposed to GL-CM, which, in turn, modulates the macrophages to M2-phenotype. glycylleucine 124-126 C-C motif chemokine ligand 2 Homo sapiens 74-79 25567426-3 2015 We report that alcohol-preferring P rats have innately elevated levels of Toll-like receptor 4 (TLR4) and monocyte chemotactic protein-1 (MCP-1) that colocalize in neurons from the central nucleus of the amygdala (CeA) and ventral tegmental area (VTA). Alcohols 15-22 C-C motif chemokine ligand 2 Homo sapiens 106-136 25567426-3 2015 We report that alcohol-preferring P rats have innately elevated levels of Toll-like receptor 4 (TLR4) and monocyte chemotactic protein-1 (MCP-1) that colocalize in neurons from the central nucleus of the amygdala (CeA) and ventral tegmental area (VTA). Alcohols 15-22 C-C motif chemokine ligand 2 Homo sapiens 138-143 25567426-6 2015 A similarly delivered amplicon for scrambled siRNA did not inhibit TLR4 or MCP-1 expression nor reduce binge drinking, identifying a neuronal TLR4/MCP-1 signal that regulates the initiation of voluntary alcohol self-administration. Alcohols 203-210 C-C motif chemokine ligand 2 Homo sapiens 147-152 25767113-5 2015 SCH-C inhibited RANTES (regulated on activation, normal T cell expressed and secreted) (CCL5)-mediated calcium flux on CCR5 with an IC50 of 22.8 nM but was inactive against monocyte chemoattractant protein-1 (CCL2)-mediated calcium flux on CCR2b. Calcium 103-110 C-C motif chemokine ligand 2 Homo sapiens 209-213 26022021-12 2015 Urinary MCP-1 correlates positively with proteinuria, blood urea nitrogen level and creatinine and negatively with hemoglobin and creatinine clearance. Urea 60-64 C-C motif chemokine ligand 2 Homo sapiens 8-13 26022021-12 2015 Urinary MCP-1 correlates positively with proteinuria, blood urea nitrogen level and creatinine and negatively with hemoglobin and creatinine clearance. Nitrogen 65-73 C-C motif chemokine ligand 2 Homo sapiens 8-13 26022021-12 2015 Urinary MCP-1 correlates positively with proteinuria, blood urea nitrogen level and creatinine and negatively with hemoglobin and creatinine clearance. Creatinine 84-94 C-C motif chemokine ligand 2 Homo sapiens 8-13 26022021-12 2015 Urinary MCP-1 correlates positively with proteinuria, blood urea nitrogen level and creatinine and negatively with hemoglobin and creatinine clearance. Creatinine 130-140 C-C motif chemokine ligand 2 Homo sapiens 8-13 25767113-6 2015 However, SCH-C inhibited CCL2-induced calcium flux against a CCR5/CCR2b chimera consisting of transmembrane domains IV-VI of CCR5 with an IC50 of 55 nM. Ancriviroc 9-14 C-C motif chemokine ligand 2 Homo sapiens 25-29 25767113-6 2015 However, SCH-C inhibited CCL2-induced calcium flux against a CCR5/CCR2b chimera consisting of transmembrane domains IV-VI of CCR5 with an IC50 of 55 nM. Calcium 38-45 C-C motif chemokine ligand 2 Homo sapiens 25-29 25919031-9 2014 These changes were at least partly ensured by the increased concentration of MCP-1 and IL-8 at 5% O2. Oxygen 98-100 C-C motif chemokine ligand 2 Homo sapiens 77-82 25897968-10 2015 Further, rosiglitazone and pioglitazone treatment reduced serum hsCRP and MCP-1 but had no marked effects on MMP-9, IL-6 and ICAM-1. Rosiglitazone 9-22 C-C motif chemokine ligand 2 Homo sapiens 74-79 25901662-1 2015 We report the crystal structure of a 40 mer mirror-image RNA oligonucleotide completely built from nucleotides of the non-natural L-chirality in complex with the pro-inflammatory chemokine L-CLL2 (monocyte chemoattractant protein-1), a natural protein composed of regular L-amino acids. Oligonucleotides 61-76 C-C motif chemokine ligand 2 Homo sapiens 197-231 25901662-1 2015 We report the crystal structure of a 40 mer mirror-image RNA oligonucleotide completely built from nucleotides of the non-natural L-chirality in complex with the pro-inflammatory chemokine L-CLL2 (monocyte chemoattractant protein-1), a natural protein composed of regular L-amino acids. Amino Acids 272-285 C-C motif chemokine ligand 2 Homo sapiens 197-231 25901662-2 2015 The L-oligonucleotide is an L-aptamer (a Spiegelmer) identified to bind L-CCL2 with high affinity, thereby neutralizing the chemokine"s activity. l-oligonucleotide 4-21 C-C motif chemokine ligand 2 Homo sapiens 74-78 25897968-10 2015 Further, rosiglitazone and pioglitazone treatment reduced serum hsCRP and MCP-1 but had no marked effects on MMP-9, IL-6 and ICAM-1. Pioglitazone 27-39 C-C motif chemokine ligand 2 Homo sapiens 74-79 26131136-3 2015 They were intervened by heparin and the expression levels of soluble thrombomodulin (sTM) and serum activated protein C (APC) were detected by ELISA, the regulatory mechanism of heparin improving vascular endothelial cells injury induced by TNFalpha was detected by Western Blotting method, the methylation of histone in the gene promoter region of endothelial nitric oxide synthase (eNOS) and monocyte chemotactic protein-1 (MCP-1) were detected using chromatin immunoprecipitation method. Heparin 178-185 C-C motif chemokine ligand 2 Homo sapiens 394-424 25763784-6 2015 Systemic levels of IFN-alpha and cervicovaginal fluid levels of IFN-alpha, CXCL10, monocyte chemotactic protein-1, and granulocyte-colony stimulating factor were significantly lower in DMPA users compared to control volunteers not using hormonal contraception. Medroxyprogesterone Acetate 185-189 C-C motif chemokine ligand 2 Homo sapiens 83-113 26131136-3 2015 They were intervened by heparin and the expression levels of soluble thrombomodulin (sTM) and serum activated protein C (APC) were detected by ELISA, the regulatory mechanism of heparin improving vascular endothelial cells injury induced by TNFalpha was detected by Western Blotting method, the methylation of histone in the gene promoter region of endothelial nitric oxide synthase (eNOS) and monocyte chemotactic protein-1 (MCP-1) were detected using chromatin immunoprecipitation method. Heparin 178-185 C-C motif chemokine ligand 2 Homo sapiens 426-431 26131136-4 2015 Results Heparin could inhibit the secretion of sTM and APC protein and the expression of MCP-1 gene which involved in NF-kappaB signal pathway. Heparin 8-15 C-C motif chemokine ligand 2 Homo sapiens 89-94 25926797-4 2015 We found that resveratrol reduced IL-6, IL-8, and MCP-1 levels in a concentration-dependent manner in adipocytes under inflammatory conditions. Resveratrol 14-25 C-C motif chemokine ligand 2 Homo sapiens 50-55 25925964-10 2015 On the other hand, EGCG and L-theanine inhibited TNF-alpha-induced adhesion of U937 cells to endothelial cells and inhibited increases in ICAM1, CCL2 and VCAM1 expression. epigallocatechin gallate 19-23 C-C motif chemokine ligand 2 Homo sapiens 145-149 25925964-10 2015 On the other hand, EGCG and L-theanine inhibited TNF-alpha-induced adhesion of U937 cells to endothelial cells and inhibited increases in ICAM1, CCL2 and VCAM1 expression. theanine 28-38 C-C motif chemokine ligand 2 Homo sapiens 145-149 25647410-10 2015 The inhibition of autophagy led to a further increase in the PA-induced expression of monocyte chemoattractant protein-1 (MCP-1) and interleukin-6 (IL-6). Palmitates 61-63 C-C motif chemokine ligand 2 Homo sapiens 86-120 25721605-12 2015 Cytokine array analysis of conditioned media revealed higher levels of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) in the CAA-conditioned medium. caa 146-149 C-C motif chemokine ligand 2 Homo sapiens 132-137 25661535-6 2015 Furthermore, gemigliptin reduced LPS-induced expression of adhesion molecules and inflammatory cytokines such as vascular cell adhesion molecule-1 (VCAM-1), E-selectin, tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1), interleukin-1beta (IL-1beta), and IL-6 in HUVECs. LC15-0444 13-24 C-C motif chemokine ligand 2 Homo sapiens 210-244 25661535-6 2015 Furthermore, gemigliptin reduced LPS-induced expression of adhesion molecules and inflammatory cytokines such as vascular cell adhesion molecule-1 (VCAM-1), E-selectin, tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1), interleukin-1beta (IL-1beta), and IL-6 in HUVECs. LC15-0444 13-24 C-C motif chemokine ligand 2 Homo sapiens 246-251 25666182-3 2015 Two putative substrates of isoQC, N-truncated Abeta peptides and the monocyte chemoattractant chemokine CCL2, undergo isoQC-catalyzed pyroglutamate (pGlu) modification. Pyrrolidonecarboxylic Acid 134-147 C-C motif chemokine ligand 2 Homo sapiens 104-108 25721605-12 2015 Cytokine array analysis of conditioned media revealed higher levels of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) in the CAA-conditioned medium. caa 146-149 C-C motif chemokine ligand 2 Homo sapiens 96-130 25519802-8 2015 DHMEQ significantly suppressed the production of both IL-8 and MCP-1 in IL-1beta-stimulated HCFs. dehydroxymethylepoxyquinomicin 0-5 C-C motif chemokine ligand 2 Homo sapiens 63-68 25519802-11 2015 CONCLUSIONS: The suppression of inflammatory chemokines IL-8 and MCP-1 and inhibition of the expression of ICAM-1 in cultured HCFs by DHMEQ indicates that DHMEQ may have a therapeutic potential for treating ICAM-1 and chemokine-mediated corneal inflammatory disorders. dehydroxymethylepoxyquinomicin 155-160 C-C motif chemokine ligand 2 Homo sapiens 65-70 25647410-10 2015 The inhibition of autophagy led to a further increase in the PA-induced expression of monocyte chemoattractant protein-1 (MCP-1) and interleukin-6 (IL-6). Palmitates 61-63 C-C motif chemokine ligand 2 Homo sapiens 122-127 26317041-10 2015 Prostate cancer cell invasion and CCL2 expression induced in the co-cultures was inhibited by Lactacystin and Bay11-7082 NF-kappaB inhibitors. 3-(4-methylphenylsulfonyl)-2-propenenitrile 110-120 C-C motif chemokine ligand 2 Homo sapiens 34-38 26122215-4 2015 Deficiency of vitamin B1 may cause beriberi, dysfunction of the nervous system, neuroinflammation, T cell infiltration, chemokine CCL2 activation, over expression of proinflammatory cytokines, such as IL-1, TNF, IL-6, and arachidonic acid products, and induces expression of CD40 by the microglia and CD40L by astrocytes which provoke the death of neurons. Thiamine 14-24 C-C motif chemokine ligand 2 Homo sapiens 130-134 26317041-10 2015 Prostate cancer cell invasion and CCL2 expression induced in the co-cultures was inhibited by Lactacystin and Bay11-7082 NF-kappaB inhibitors. lactacystin 94-105 C-C motif chemokine ligand 2 Homo sapiens 34-38 25716997-0 2015 Buprenorphine decreases the CCL2-mediated chemotactic response of monocytes. Buprenorphine 0-13 C-C motif chemokine ligand 2 Homo sapiens 28-32 25716997-7 2015 Buprenorphine decreases the formation of membrane projections in response to CCL2. Buprenorphine 0-13 C-C motif chemokine ligand 2 Homo sapiens 77-81 25716997-8 2015 It also decreases CCL2-induced chemotaxis and mediates a delay in reinsertion of the CCL2 receptor, CCR2, into the cell membrane after CCL2-mediated receptor internalization, suggesting a mechanism of action of buprenorphine. Buprenorphine 211-224 C-C motif chemokine ligand 2 Homo sapiens 18-22 25716997-8 2015 It also decreases CCL2-induced chemotaxis and mediates a delay in reinsertion of the CCL2 receptor, CCR2, into the cell membrane after CCL2-mediated receptor internalization, suggesting a mechanism of action of buprenorphine. Buprenorphine 211-224 C-C motif chemokine ligand 2 Homo sapiens 85-89 25716997-8 2015 It also decreases CCL2-induced chemotaxis and mediates a delay in reinsertion of the CCL2 receptor, CCR2, into the cell membrane after CCL2-mediated receptor internalization, suggesting a mechanism of action of buprenorphine. Buprenorphine 211-224 C-C motif chemokine ligand 2 Homo sapiens 85-89 25716997-10 2015 We show that buprenorphine decreases these phosphorylations in CCL2-treated monocytes. Buprenorphine 13-26 C-C motif chemokine ligand 2 Homo sapiens 63-67 25716997-11 2015 Using DAMGO, CTAP, and Nor-BNI, we demonstrate that the effect of buprenorphine on CCL2 signaling is opioid receptor mediated. CTAP 13-17 C-C motif chemokine ligand 2 Homo sapiens 83-87 25716997-11 2015 Using DAMGO, CTAP, and Nor-BNI, we demonstrate that the effect of buprenorphine on CCL2 signaling is opioid receptor mediated. norbinaltorphimine 23-30 C-C motif chemokine ligand 2 Homo sapiens 83-87 25716997-11 2015 Using DAMGO, CTAP, and Nor-BNI, we demonstrate that the effect of buprenorphine on CCL2 signaling is opioid receptor mediated. Buprenorphine 66-79 C-C motif chemokine ligand 2 Homo sapiens 83-87 25716997-12 2015 To identify additional potential mechanisms by which buprenorphine inhibits CCL2-induced monocyte migration, we performed proteomic analyses to characterize additional proteins in monocytes whose phosphorylation after CCL2 treatment was inhibited by buprenorphine. Buprenorphine 53-66 C-C motif chemokine ligand 2 Homo sapiens 76-80 25716997-12 2015 To identify additional potential mechanisms by which buprenorphine inhibits CCL2-induced monocyte migration, we performed proteomic analyses to characterize additional proteins in monocytes whose phosphorylation after CCL2 treatment was inhibited by buprenorphine. Buprenorphine 53-66 C-C motif chemokine ligand 2 Homo sapiens 218-222 25716997-12 2015 To identify additional potential mechanisms by which buprenorphine inhibits CCL2-induced monocyte migration, we performed proteomic analyses to characterize additional proteins in monocytes whose phosphorylation after CCL2 treatment was inhibited by buprenorphine. Buprenorphine 250-263 C-C motif chemokine ligand 2 Homo sapiens 76-80 25716997-12 2015 To identify additional potential mechanisms by which buprenorphine inhibits CCL2-induced monocyte migration, we performed proteomic analyses to characterize additional proteins in monocytes whose phosphorylation after CCL2 treatment was inhibited by buprenorphine. Buprenorphine 250-263 C-C motif chemokine ligand 2 Homo sapiens 218-222 25716997-14 2015 We propose that buprenorphine limits CCL2-mediated monocyte transmigration into the CNS, thereby reducing neuroinflammation characteristic of HAND. Buprenorphine 16-29 C-C motif chemokine ligand 2 Homo sapiens 37-41 26015780-0 2015 Exhaled nitric oxide correlates with IL-2, MCP-1, PDGF-BB and TIMP-2 in exhaled breath condensate of children with refractory asthma. Nitric Oxide 8-20 C-C motif chemokine ligand 2 Homo sapiens 43-48 25557254-0 2015 22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRalpha. 22-hydroxycholesterol 0-23 C-C motif chemokine ligand 2 Homo sapiens 115-120 25557254-0 2015 22-S-Hydroxycholesterol protects against ethanol-induced liver injury by blocking the auto/paracrine activation of MCP-1 mediated by LXRalpha. Ethanol 41-48 C-C motif chemokine ligand 2 Homo sapiens 115-120 25557254-4 2015 Here, we show the role of liver X receptor alpha (LXRalpha) in the regulation of MCP-1 expression during the development of ethanol-induced fatty liver injury, using an antagonist, 22-S-hydroxycholesterol (22-S-HC). Ethanol 124-131 C-C motif chemokine ligand 2 Homo sapiens 81-86 25557254-4 2015 Here, we show the role of liver X receptor alpha (LXRalpha) in the regulation of MCP-1 expression during the development of ethanol-induced fatty liver injury, using an antagonist, 22-S-hydroxycholesterol (22-S-HC). 22-hydroxycholesterol 181-204 C-C motif chemokine ligand 2 Homo sapiens 81-86 25557254-4 2015 Here, we show the role of liver X receptor alpha (LXRalpha) in the regulation of MCP-1 expression during the development of ethanol-induced fatty liver injury, using an antagonist, 22-S-hydroxycholesterol (22-S-HC). 22-hydroxycholesterol 206-213 C-C motif chemokine ligand 2 Homo sapiens 81-86 25557254-6 2015 Second, hypoxic conditions or treatment with the LXRalpha agonist GW3965 significantly induced the expression of MCP-1, which was completely blocked by treatment with 22-S-HC or infection by shLXRalpha lentivirus in the primary hepatocytes. GW 3965 66-72 C-C motif chemokine ligand 2 Homo sapiens 113-118 25557254-7 2015 Third, over-expression of LXRalpha or GW3965 treatment increased MCP-1 promoter activity by increasing the binding of hypoxia-inducible factor-1alpha to the hypoxia response elements, together with LXRalpha. GW 3965 38-44 C-C motif chemokine ligand 2 Homo sapiens 65-70 26015780-8 2015 We showed a significant positive correlation between the FeNO level and crucial mediators in asthma development and progression (IL-2, MCP-1), and potent markers of airway remodeling (PDGFBB, TIMP-2). feno 57-61 C-C motif chemokine ligand 2 Homo sapiens 135-140 25413674-8 2015 GBS induced a massive weight and fat mass loss, improved insulin sensitivity and lipid profile, decreased C-reactive protein, leptin, and CCL2 levels. gbs 0-3 C-C motif chemokine ligand 2 Homo sapiens 138-142 25595138-8 2015 Improvements in ACQ and/or AQLQ scores with atorvastatin and ICS were associated with decreases in G-CSF, IL-7, CCL2 and CXCL8. acenaphthenequinone 16-19 C-C motif chemokine ligand 2 Homo sapiens 112-116 25595138-8 2015 Improvements in ACQ and/or AQLQ scores with atorvastatin and ICS were associated with decreases in G-CSF, IL-7, CCL2 and CXCL8. aqlq 27-31 C-C motif chemokine ligand 2 Homo sapiens 112-116 25595138-8 2015 Improvements in ACQ and/or AQLQ scores with atorvastatin and ICS were associated with decreases in G-CSF, IL-7, CCL2 and CXCL8. Atorvastatin 44-56 C-C motif chemokine ligand 2 Homo sapiens 112-116 25413674-12 2015 In vitro, OEA inhibited CCL2 secretion from adipocytes via ERK1/2 activation. N-oleoylethanolamine 10-13 C-C motif chemokine ligand 2 Homo sapiens 24-28 25413674-14 2015 OEA directly reduced CCL2 secretion via ERK1/2 activation in adipocytes. N-oleoylethanolamine 0-3 C-C motif chemokine ligand 2 Homo sapiens 21-25 25870583-5 2015 The combined fold-changes in plasma levels of PRDX6, S100b, MCP1, NSE, and BDNF resulted in the formulation of a TBI assessment score that identified mTBI with a receiver operating characteristic (ROC) area under the curve of 0.97, when compared to healthy controls. Thioacetazone 113-116 C-C motif chemokine ligand 2 Homo sapiens 60-64 25767679-2 2015 In this study, we investigated the effect of 3-(4-Hydroxyphenyl)-1-(thio3-(4-Hydroxyphenyl phen-2-yl)prop-2-en-1-one (TI-I-175), a synthetic chalcone derivative, on endotoxin-induced expression of monocyte chemoattractant protein-1 (MCP-1), one of the key chemokines that regulates migration and infiltration of immune cells, and its potential mechanisms. 3-(4-hydroxyphenyl)-1-(thio3 45-73 C-C motif chemokine ligand 2 Homo sapiens 197-231 25497142-0 2015 27-Hydroxycholesterol up-regulates CD14 and predisposes monocytic cells to superproduction of CCL2 in response to lipopolysaccharide. 27-hydroxycholesterol 0-21 C-C motif chemokine ligand 2 Homo sapiens 94-98 25497142-4 2015 Additions of lipopolysaccharide (LPS) to 27OHChol-treated THP-1 monocytic cells resulted in superinduction in terms of the gene transcription of CCL2 and the secretion of its gene product. 27ohchol 41-49 C-C motif chemokine ligand 2 Homo sapiens 145-149 25819872-5 2015 PHY906 may potentiate Sorafenib action by increasing hMCP1 expression and enhancing infiltration of macrophages into tumors with a higher M1/M2 (tumor rejection) signature expression pattern, as well as affect autophagy by increasing AMPKalpha-P and ULK1-S555-P of tumors. Sorafenib 22-31 C-C motif chemokine ligand 2 Homo sapiens 53-58 25889689-0 2015 Inhibition of the spinal astrocytic JNK/MCP-1 pathway activation correlates with the analgesic effects of tanshinone IIA sulfonate in neuropathic pain. tanshinone II A sodium sulfonate 106-130 C-C motif chemokine ligand 2 Homo sapiens 40-45 25744297-5 2015 Cell adhesion markers, such as MCP-1 and ICAM-1, were significantly reduced by scoparone. scoparone 79-88 C-C motif chemokine ligand 2 Homo sapiens 31-36 25658848-7 2015 Additionally, of the two polymers tested, it was found that the stiffer substrate resulted in significant decreases in the secretion of IL-3 and MCP-1. Polymers 25-33 C-C motif chemokine ligand 2 Homo sapiens 145-150 25767679-0 2015 Inhibitory Effect of 3-(4-Hydroxyphenyl)-1-(thiophen-2-yl) prop-2-en-1-one, a Chalcone Derivative on MCP-1 Expression in Macrophages via Inhibition of ROS and Akt Signaling. 3-(4-hydroxyphenyl)-1-(thiophen-2-yl) prop-2-en-1-one 21-74 C-C motif chemokine ligand 2 Homo sapiens 101-106 25767679-0 2015 Inhibitory Effect of 3-(4-Hydroxyphenyl)-1-(thiophen-2-yl) prop-2-en-1-one, a Chalcone Derivative on MCP-1 Expression in Macrophages via Inhibition of ROS and Akt Signaling. Chalcone 78-86 C-C motif chemokine ligand 2 Homo sapiens 101-106 25767679-0 2015 Inhibitory Effect of 3-(4-Hydroxyphenyl)-1-(thiophen-2-yl) prop-2-en-1-one, a Chalcone Derivative on MCP-1 Expression in Macrophages via Inhibition of ROS and Akt Signaling. Reactive Oxygen Species 151-154 C-C motif chemokine ligand 2 Homo sapiens 101-106 25767679-2 2015 In this study, we investigated the effect of 3-(4-Hydroxyphenyl)-1-(thio3-(4-Hydroxyphenyl phen-2-yl)prop-2-en-1-one (TI-I-175), a synthetic chalcone derivative, on endotoxin-induced expression of monocyte chemoattractant protein-1 (MCP-1), one of the key chemokines that regulates migration and infiltration of immune cells, and its potential mechanisms. 3-(4-hydroxyphenyl)-1-(thio3 45-73 C-C motif chemokine ligand 2 Homo sapiens 233-238 25767679-3 2015 TII-175 potently inhibited MCP-1 mRNA expression stimulated by lipopolysaccharide (LPS) in RAW 264.7 macrophages without significant effect on cell viability. tii-175 0-7 C-C motif chemokine ligand 2 Homo sapiens 27-32 25767679-4 2015 Treatment of cells with TI-I-175 markedly prevented LPS-induced transcriptional activation of activator protein-1 (AP-1) as measured by luciferase reporter assay, while nuclear factor-kappaB (NF-kappaB) activity was not inhibited by TI-I-175, implying that TI-I-175 suppressed MCP-1 expression probably via regulation of AP-1. ti-i 24-28 C-C motif chemokine ligand 2 Homo sapiens 277-282 25391768-11 2015 This is probably because the additional glycine residues present at the N-terminus of hCCL2 following TEV digestion interfere with the binding of hCCL2 to its receptor. Glycine 40-47 C-C motif chemokine ligand 2 Homo sapiens 86-91 25746024-8 2015 Monocyte chemoattractant protein-1, interferon gamma-induced protein, and C-reactive protein levels were higher in the CF-LVAD recipients at each of the time points (baseline before CF-LVAD implantation and 3, 6, and 9 months after implantation) compared with levels in healthy controls. lvad 122-126 C-C motif chemokine ligand 2 Homo sapiens 0-34 24806810-5 2015 RESULTS: P. gingivalis LPS induced cytokine/chemokine (IL-6, IL-8, MCP-1, and GRO) protein production in HGFs, and this effect was suppressed by azithromycin at all concentrations tested. Azithromycin 145-157 C-C motif chemokine ligand 2 Homo sapiens 67-72 24766056-8 2015 In patients with mild ALD, 1 week of alcohol withdrawal was sufficient to decrease expression level of total macrophage markers in the adipose tissue, to orient adipose tissue macrophages (ATM) towards an anti-inflammatory M2 phenotype and to decrease the mRNA expression of cytokines/chemokines (IL18, CCL2, osteopontin, semaphorin 7A). Alcohols 37-44 C-C motif chemokine ligand 2 Homo sapiens 303-307 25127747-10 2015 CONCLUSION: Plasma levels of MCP-1, galectin -3 and NT-proBNP improve the ability of the LIPID clinical scale to predict the prognosis of patients with SCAD. lipid 89-94 C-C motif chemokine ligand 2 Homo sapiens 29-34 25391768-11 2015 This is probably because the additional glycine residues present at the N-terminus of hCCL2 following TEV digestion interfere with the binding of hCCL2 to its receptor. Glycine 40-47 C-C motif chemokine ligand 2 Homo sapiens 146-151 26120598-6 2015 Further investigation into the effects of metformin suggest that the drug directly activates AMPK and dose-dependently suppressed the release of TNF-alpha, IL-6, and MCP-1 by macrophages while enhancing the release of IL-10 in vitro. Metformin 42-51 C-C motif chemokine ligand 2 Homo sapiens 166-171 25738355-5 2015 hMCP1 siRNA-DOPC nanoparticles significantly abrogated daily restraint stress-induced tumor growth and inhibited infiltration of CD68+ and F4/80+ cells. 1,2-oleoylphosphatidylcholine 12-16 C-C motif chemokine ligand 2 Homo sapiens 0-5 23524880-8 2015 CIT markedly increased TNF-alpha-induced HUVECs adhesion to monocytes and the expression levels of ICAM-1, VCAM-1, E-selectin, and MCP-1. citreoviridin 0-3 C-C motif chemokine ligand 2 Homo sapiens 131-136 23524880-10 2015 Our study demonstrates that CIT upregulates TNF-alpha-induced endothelial adhesion via increasing activation of NF-kappaB, which results in the expression of ICAM-1, VCAM-1, E-selectin, and MCP-1. citreoviridin 28-31 C-C motif chemokine ligand 2 Homo sapiens 190-195 25536525-0 2015 Phosphate modulates receptor sulfotyrosine recognition by the chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). Phosphates 0-9 C-C motif chemokine ligand 2 Homo sapiens 72-106 25499119-4 2015 The level of SuPAR has been measured in PJI patients and healthy controls, correlated with canonical inflammatory markers, such as C-reactive protein, IL-6, IL-1 and TNFalpha and the chemokine CCL2. supar 13-18 C-C motif chemokine ligand 2 Homo sapiens 193-197 25499119-5 2015 Serum suPAR displayed a strongly significative increase in PJI patients compared to not infected controls, and a significative positive correlation with C-reactive protein, IL-6, IL-1 and TNFalpha and the chemokine CCL2. supar 6-11 C-C motif chemokine ligand 2 Homo sapiens 215-219 25536525-0 2015 Phosphate modulates receptor sulfotyrosine recognition by the chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). Phosphates 0-9 C-C motif chemokine ligand 2 Homo sapiens 108-113 25499119-6 2015 Also serum CCL2 showed statistically significative increase in PJI patients, and it displayed a strong positive correlation with serum suPAR. supar 135-140 C-C motif chemokine ligand 2 Homo sapiens 11-15 25536525-0 2015 Phosphate modulates receptor sulfotyrosine recognition by the chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). Phosphates 0-9 C-C motif chemokine ligand 2 Homo sapiens 114-118 25536525-0 2015 Phosphate modulates receptor sulfotyrosine recognition by the chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). tyrosine O-sulfate 29-42 C-C motif chemokine ligand 2 Homo sapiens 72-106 25536525-0 2015 Phosphate modulates receptor sulfotyrosine recognition by the chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). tyrosine O-sulfate 29-42 C-C motif chemokine ligand 2 Homo sapiens 108-113 25536525-0 2015 Phosphate modulates receptor sulfotyrosine recognition by the chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). tyrosine O-sulfate 29-42 C-C motif chemokine ligand 2 Homo sapiens 114-118 25521217-5 2015 RESULTS: These show that TiO2 nanotube surfaces, especially of 80 nm TiO2 nanotube, benefited macrophage adhesion and proliferation, and reduced protein secretion and mRNA expression of TNF-alpha, MCP-1 and MIP-1alpha. titanium dioxide 25-29 C-C motif chemokine ligand 2 Homo sapiens 197-202 25560198-7 2015 BHMC concentration-dependently reduced endothelial hyperpermeability, leukocyte-endothelial cell adhesion and monocyte transendothelial migration through inhibition of the protein expression of adhesion molecules (Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1) and secretion of chemokines (Monocyte Chemotactic Protein-1) at the transcriptional level. bhmc 0-4 C-C motif chemokine ligand 2 Homo sapiens 316-346 25581570-12 2015 Furthermore, AGE- or MGO-induced increased expression of VEGF and MCP-1 was significantly reduced in the presence of NAC or SB203580. Pyruvaldehyde 21-24 C-C motif chemokine ligand 2 Homo sapiens 66-71 25581570-12 2015 Furthermore, AGE- or MGO-induced increased expression of VEGF and MCP-1 was significantly reduced in the presence of NAC or SB203580. Acetylcysteine 117-120 C-C motif chemokine ligand 2 Homo sapiens 66-71 25581570-12 2015 Furthermore, AGE- or MGO-induced increased expression of VEGF and MCP-1 was significantly reduced in the presence of NAC or SB203580. SB 203580 124-132 C-C motif chemokine ligand 2 Homo sapiens 66-71 25581570-13 2015 CONCLUSIONS: Together, this study suggested that AGE or MGO promoted VEGF and MCP-1 expression through activation of p38 MAPK signaling. Pyruvaldehyde 56-59 C-C motif chemokine ligand 2 Homo sapiens 78-83 25621970-0 2015 6-shogaol, an active constituent of dietary ginger, impairs cancer development and lung metastasis by inhibiting the secretion of CC-chemokine ligand 2 (CCL2) in tumor-associated dendritic cells. shogaol 0-9 C-C motif chemokine ligand 2 Homo sapiens 130-151 25621970-3 2015 6-Shogaol decreases cancer-induced up-regulation of CCL2 in TADCs, preventing the enhancing effects of TADCs on tumorigenesis and metastatic properties in A549 and MDA-MB-231 cells. shogaol 0-9 C-C motif chemokine ligand 2 Homo sapiens 52-56 25621970-4 2015 A549 and MDA-MB-231 cells enhance CCL2 expression by increasing the phosphorylation of signal transducer and activator of transcription 3 (STAT3), and the activation of STAT3 induced by A549 and MDA-MB-231 is completely inhibited by 6-shogaol. shogaol 233-242 C-C motif chemokine ligand 2 Homo sapiens 34-38 25581570-9 2015 The mRNA and protein expression of cytokines including vascular endothelial growth factor (VEGF) and monocyte chemotactic protein-1 (MCP-1) was significantly increased after treatment with MGO and AGE-HSA. Pyruvaldehyde 189-192 C-C motif chemokine ligand 2 Homo sapiens 101-131 25581570-9 2015 The mRNA and protein expression of cytokines including vascular endothelial growth factor (VEGF) and monocyte chemotactic protein-1 (MCP-1) was significantly increased after treatment with MGO and AGE-HSA. Pyruvaldehyde 189-192 C-C motif chemokine ligand 2 Homo sapiens 133-138 25581570-9 2015 The mRNA and protein expression of cytokines including vascular endothelial growth factor (VEGF) and monocyte chemotactic protein-1 (MCP-1) was significantly increased after treatment with MGO and AGE-HSA. Altretamine 201-204 C-C motif chemokine ligand 2 Homo sapiens 101-131 25581570-9 2015 The mRNA and protein expression of cytokines including vascular endothelial growth factor (VEGF) and monocyte chemotactic protein-1 (MCP-1) was significantly increased after treatment with MGO and AGE-HSA. Altretamine 201-204 C-C motif chemokine ligand 2 Homo sapiens 133-138 25585347-0 2015 Iopromide in combination with IFN-gamma induces the activation of HMC-1 cells via IL-4 and MCP-1 expression. iopromide 0-9 C-C motif chemokine ligand 2 Homo sapiens 91-96 25585347-2 2015 Iopromide, a nonionic iodinated contrast agent, slightly induced mast cell proliferation and significantly increased the expression of IL-4 and MCP-1 at low doses. iopromide 0-9 C-C motif chemokine ligand 2 Homo sapiens 144-149 25511715-7 2015 RESULTS: ALA significantly increased VEGF, bFGF and IL-10 and decreased MCP-1 serum concentrations in patients with T2DM and CAD and DSPN. Thioctic Acid 9-12 C-C motif chemokine ligand 2 Homo sapiens 72-77 25464927-8 2015 However, standard DTT-processing resulted in lower detectable concentrations of ferritin, TIMP-1, MCP-1, MIP-1beta, ICAM-1, and complement C3. Dithiothreitol 18-21 C-C motif chemokine ligand 2 Homo sapiens 98-103 25511715-9 2015 CONCLUSIONS: ALA may influence angiogenesis in type 2 diabetic patients through an effect on some circulating factors including VEGF, bFGF, MCP-1 and IL-10. Thioctic Acid 13-16 C-C motif chemokine ligand 2 Homo sapiens 140-145 25398834-6 2015 We found that lenalidomide induces high actin polymerization on CD14(+) monocytes through activation of small GTPases, RhoA, Rac1 and Rap1 that correlated with increased adhesion and impaired monocyte migration in response to CCL2, CCL3 and CXCL12. Lenalidomide 14-26 C-C motif chemokine ligand 2 Homo sapiens 226-230 25398834-8 2015 Gene expression signature, induced by lenalidomide in nurse-like cells, indicated a reduction of pivotal pro-survival signals for chronic lymphocytic leukemia, such as CCL2, IGF1, CXCL12, HGF1, and supported a modulation towards M1 phenotype with high IL2 and low IL10, IL8 and CD163. Lenalidomide 38-50 C-C motif chemokine ligand 2 Homo sapiens 168-172 25272052-7 2015 P2X7R antagonists, such as the oxidized ATP, A438079, brilliant blue G, and broad spectrum P2 receptor antagonist suramin, attenuated Tat-induced CCL2 release in a calcium- and extracellular signal-regulated kinase (ERK)1/2-dependent manner. Adenosine Triphosphate 40-43 C-C motif chemokine ligand 2 Homo sapiens 146-150 25272052-13 2015 We proposed the following cascade for Tat-mediated CCL2 release from astrocytes: Tat mediates increase in P2X7R expression, which on activation evokes increase in intracellular calcium, which further leads to phosphorylation of ERK1/2 followed by the release of CCL2 from astrocytes. Calcium 177-184 C-C motif chemokine ligand 2 Homo sapiens 51-55 25272052-7 2015 P2X7R antagonists, such as the oxidized ATP, A438079, brilliant blue G, and broad spectrum P2 receptor antagonist suramin, attenuated Tat-induced CCL2 release in a calcium- and extracellular signal-regulated kinase (ERK)1/2-dependent manner. 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine 45-52 C-C motif chemokine ligand 2 Homo sapiens 146-150 25272052-13 2015 We proposed the following cascade for Tat-mediated CCL2 release from astrocytes: Tat mediates increase in P2X7R expression, which on activation evokes increase in intracellular calcium, which further leads to phosphorylation of ERK1/2 followed by the release of CCL2 from astrocytes. Calcium 177-184 C-C motif chemokine ligand 2 Homo sapiens 262-266 25272052-7 2015 P2X7R antagonists, such as the oxidized ATP, A438079, brilliant blue G, and broad spectrum P2 receptor antagonist suramin, attenuated Tat-induced CCL2 release in a calcium- and extracellular signal-regulated kinase (ERK)1/2-dependent manner. coomassie Brilliant Blue 54-70 C-C motif chemokine ligand 2 Homo sapiens 146-150 25272052-7 2015 P2X7R antagonists, such as the oxidized ATP, A438079, brilliant blue G, and broad spectrum P2 receptor antagonist suramin, attenuated Tat-induced CCL2 release in a calcium- and extracellular signal-regulated kinase (ERK)1/2-dependent manner. Suramin 114-121 C-C motif chemokine ligand 2 Homo sapiens 146-150 25272052-7 2015 P2X7R antagonists, such as the oxidized ATP, A438079, brilliant blue G, and broad spectrum P2 receptor antagonist suramin, attenuated Tat-induced CCL2 release in a calcium- and extracellular signal-regulated kinase (ERK)1/2-dependent manner. Calcium 164-171 C-C motif chemokine ligand 2 Homo sapiens 146-150 25692011-6 2015 PCS also up-regulates the mRNA levels and the protein secretion of monocyte chemotactic protein-1 (MCP-1) in HUVEC. 4-cresol sulfate 0-3 C-C motif chemokine ligand 2 Homo sapiens 67-97 25374119-5 2015 The results demonstrated that simvastatin suppressed the increased mRNA expression of monocyte chemoattractant protein-1, tumor necrosis factor-alpha, interleukin (IL)-1beta and IL-6 and the content of reactive oxygen species induced by Ang II in a dose-dependent manner. Simvastatin 30-41 C-C motif chemokine ligand 2 Homo sapiens 86-149 25204316-10 2015 Supplementation of omega-3 PUFAs effectively decreased the LPS-induced PBMC expression of RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) and MCP-1 (Monocyte Chemotactic Protein-1; unadjusted P = 0.04 and 0.06; adjusted for demographics P = 0.02 and 0.05, respectively). Fatty Acids, Omega-3 19-32 C-C motif chemokine ligand 2 Homo sapiens 167-172 25204316-10 2015 Supplementation of omega-3 PUFAs effectively decreased the LPS-induced PBMC expression of RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted) and MCP-1 (Monocyte Chemotactic Protein-1; unadjusted P = 0.04 and 0.06; adjusted for demographics P = 0.02 and 0.05, respectively). Fatty Acids, Omega-3 19-32 C-C motif chemokine ligand 2 Homo sapiens 174-204 25204316-12 2015 CONCLUSIONS: The results of this pilot study suggest that supplementation of omega-3 PUFAs is beneficial in decreasing the levels of endothelial chemokines, RANTES and MCP-1. Fatty Acids, Omega-3 77-90 C-C motif chemokine ligand 2 Homo sapiens 168-173 25692011-6 2015 PCS also up-regulates the mRNA levels and the protein secretion of monocyte chemotactic protein-1 (MCP-1) in HUVEC. 4-cresol sulfate 0-3 C-C motif chemokine ligand 2 Homo sapiens 99-104 25622857-9 2015 Conversely, blockage of alcohol-mediated ROS accumulation and NF-kappaB signaling inhibited alcohol-induced expression of VEGF and MCP-1, the tumor growth, angiogenesis and metastasis. Alcohols 92-99 C-C motif chemokine ligand 2 Homo sapiens 131-136 25529449-9 2015 Statins suppressed migration and proliferation of HASMCs, and inhibited lipopolysaccharide-induced expression of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) in HASMCs. hasmcs 203-209 C-C motif chemokine ligand 2 Homo sapiens 113-147 25529449-9 2015 Statins suppressed migration and proliferation of HASMCs, and inhibited lipopolysaccharide-induced expression of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) in HASMCs. hasmcs 203-209 C-C motif chemokine ligand 2 Homo sapiens 149-154 25629558-9 2015 However, only DHA and DHA/ARA exerted a potentanti-inflammatory effect reflected by prevention of tumor necrosis factor-alpha (TNF-alpha) induced NF-kappaB activation and MCP-1 secretion in human adipocytes. Docosahexaenoic Acids 14-17 C-C motif chemokine ligand 2 Homo sapiens 171-176 25629558-9 2015 However, only DHA and DHA/ARA exerted a potentanti-inflammatory effect reflected by prevention of tumor necrosis factor-alpha (TNF-alpha) induced NF-kappaB activation and MCP-1 secretion in human adipocytes. Docosahexaenoic Acids 22-25 C-C motif chemokine ligand 2 Homo sapiens 171-176 25529444-6 2015 Mechanistically, we found that GA ameliorated the upregulation of MCP-1, VCAM-1, and E-selectin induced by TNF-alpha. Glatiramer Acetate 31-33 C-C motif chemokine ligand 2 Homo sapiens 66-71 25622857-7 2015 Consistently, higher expression of VEGF, MCP-1 and NF-kappaB was observed in HCC tissues of alcohol-drinkers. Alcohols 92-99 C-C motif chemokine ligand 2 Homo sapiens 41-46 25622857-9 2015 Conversely, blockage of alcohol-mediated ROS accumulation and NF-kappaB signaling inhibited alcohol-induced expression of VEGF and MCP-1, the tumor growth, angiogenesis and metastasis. Alcohols 24-31 C-C motif chemokine ligand 2 Homo sapiens 131-136 25622857-9 2015 Conversely, blockage of alcohol-mediated ROS accumulation and NF-kappaB signaling inhibited alcohol-induced expression of VEGF and MCP-1, the tumor growth, angiogenesis and metastasis. Reactive Oxygen Species 41-44 C-C motif chemokine ligand 2 Homo sapiens 131-136 25629558-9 2015 However, only DHA and DHA/ARA exerted a potentanti-inflammatory effect reflected by prevention of tumor necrosis factor-alpha (TNF-alpha) induced NF-kappaB activation and MCP-1 secretion in human adipocytes. Arachidonic Acid 26-29 C-C motif chemokine ligand 2 Homo sapiens 171-176 25622857-10 2015 CONCLUSION: This study suggested that chronic moderate alcohol consumption may promote the progression and metastasis of HCC; the oncogenic effect may be at least partially mediated by the ROS accumulation and NF-kB-dependent VEGF and MCP-1 up-regulation. Alcohols 55-62 C-C motif chemokine ligand 2 Homo sapiens 235-240 25447894-2 2015 TRIB3 can inhibit FFA and reactive oxygen species (ROS) stimulated podocyte production of MCP-1. Reactive Oxygen Species 26-49 C-C motif chemokine ligand 2 Homo sapiens 90-95 25447894-2 2015 TRIB3 can inhibit FFA and reactive oxygen species (ROS) stimulated podocyte production of MCP-1. Reactive Oxygen Species 51-54 C-C motif chemokine ligand 2 Homo sapiens 90-95 25366592-7 2015 Currently, we propose that IA is a chronic inflammatory disease regulated by a positive feedback loop consisting of the cyclooxygenase (COX)-2 - prostaglandin (PG) E2 - prostaglandin E receptor 2 (EP2) - nuclear factor (NF)-kappaB signaling pathway triggered under hemodynamic stress and macrophage infiltration via NF-kappaB-mediated monocyte chemoattractant protein (MCP)-1 induction. prostaglandin (pg 145-162 C-C motif chemokine ligand 2 Homo sapiens 335-375 25785032-0 2015 Ghrelin inhibits AngII -induced expression of TNF-alpha, IL-8, MCP-1 in human umbilical vein endothelial cells. Ghrelin 0-7 C-C motif chemokine ligand 2 Homo sapiens 63-68 25785032-5 2015 The aim of this study is to examine the effect of ghrelin on angiotension II (AngII)-induced expression of TNF-alpha, MCP-1, IL-8 in HUVECs. Ghrelin 50-57 C-C motif chemokine ligand 2 Homo sapiens 118-123 25785032-10 2015 RESULT: our study showed that ghrelin inhibited AngII -induced expression of IL-8, TNF-alpha and MCP-1 in the HUVECs via GHSR pathway in concentration- and time-dependent manners. Ghrelin 30-37 C-C motif chemokine ligand 2 Homo sapiens 97-102 25449925-5 2015 Chitosan enhanced anabolic factor release from M0 and M2a macrophages (MCP-1, IP-10, MIP-1beta, IL-1ra, IL-10, PDGF), and IL-1beta release, with 25- to 400-fold excess IL-1ra over IL-1beta. Chitosan 0-8 C-C motif chemokine ligand 2 Homo sapiens 71-76 25608886-4 2015 In this study, we dissected the molecular mechanisms by which CCL2 neutralization inhibits HIV-1 replication in monocyte-derived macrophages (MDM), and the potential involvement of the innate restriction factors protein sterile alpha motif (SAM) histidine/aspartic acid (HD) domain containing 1 (SAMHD1) and apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3 (APOBEC3) family members. Histidine 246-255 C-C motif chemokine ligand 2 Homo sapiens 62-66 25608886-4 2015 In this study, we dissected the molecular mechanisms by which CCL2 neutralization inhibits HIV-1 replication in monocyte-derived macrophages (MDM), and the potential involvement of the innate restriction factors protein sterile alpha motif (SAM) histidine/aspartic acid (HD) domain containing 1 (SAMHD1) and apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3 (APOBEC3) family members. Aspartic Acid 256-269 C-C motif chemokine ligand 2 Homo sapiens 62-66 25608886-5 2015 RESULTS: CCL2 neutralization potently reduced the number of p24 Gag+ cells during the course of either productive or single cycle infection with HIV-1. Glycosaminoglycans 64-67 C-C motif chemokine ligand 2 Homo sapiens 9-13 25445541-4 2015 The LPS-induced release of these cytokines was also modulated by purinergic receptor activation since IL-8 and MCP-1 release was decreased by the nucleotide scavenger apyrase as well as by the pharmacological P2Y6 receptor antagonists suramin and MRS2578. Suramin 235-242 C-C motif chemokine ligand 2 Homo sapiens 111-116 25807959-0 2015 Ginsenoside Rg1 downregulates the shear stress induced MCP-1 expression by inhibiting MAPK signaling pathway. Ginsenosides 0-11 C-C motif chemokine ligand 2 Homo sapiens 55-60 24285492-8 2015 RESULTS: In rheumatoid arthritis synovial fibroblasts (RASF), FFA dose-dependently enhanced the secretion of the proinflammatory cytokine IL-6, the chemokines IL-8 and MCP-1, as well as the matrix-degrading enzymes pro-MMP1 and MMP3. Fatty Acids, Nonesterified 62-65 C-C motif chemokine ligand 2 Homo sapiens 168-173 25445541-4 2015 The LPS-induced release of these cytokines was also modulated by purinergic receptor activation since IL-8 and MCP-1 release was decreased by the nucleotide scavenger apyrase as well as by the pharmacological P2Y6 receptor antagonists suramin and MRS2578. N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea 247-254 C-C motif chemokine ligand 2 Homo sapiens 111-116 25714853-5 2015 Most interestingly, the novel multiple tyrosine kinase inhibitor Dovitinib significantly blocked the CAFs-induced invasion of breast cancer cells by, at least in part, inhibition of the expression and secretion of CCL2, CCL5 and VEGF in CAFs. 4-amino-5-fluoro-3-(5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl)quinolin-2(1H)-one 65-74 C-C motif chemokine ligand 2 Homo sapiens 214-218 26345342-6 2015 We further examined the chemoattractant expression in melanocytes and demonstrated that EGCG significantly inhibited IFN-gamma-induced expression of intracellular adhesion molecule (ICAM)-1, CXCL10, and monocyte chemotactic protein (MCP)-1 in human melanocytes. epigallocatechin gallate 88-92 C-C motif chemokine ligand 2 Homo sapiens 203-239 26050467-1 2015 Automated Fmoc solid-phase technique was used to synthesize Cys-containing linear peptide fragments of monocyte chemoattractant protein-1 and chemokine domain of fractalkine along with their analogues with Cys residue being either modified or replaced with Ser. Cysteine 60-63 C-C motif chemokine ligand 2 Homo sapiens 103-137 26309782-13 2015 Minimally glycoxidized pentosidine-rich collagen suppressed most mRNAs of the genes studied (p<0.05) and decreased VEGF and increased MCP1 protein expression. pentosidine 23-34 C-C motif chemokine ligand 2 Homo sapiens 137-141 25420194-6 2015 We found that the infarct and border zones of rat myocardium treated with h-AECs had higher expression levels of the human-origin cytokines ANG, EGF, IL-6, and MCP-1 compared to the tissues of saline-treated rats. h-aecs 74-80 C-C motif chemokine ligand 2 Homo sapiens 160-165 25613133-5 2015 In addition, dCA potently inhibits Tat mediated dysregulation of IL-1beta, TNF-alpha and MCP-1, key neuroinflammatory signaling proteins. didehydro-cortistatin A 13-16 C-C motif chemokine ligand 2 Homo sapiens 89-94 25591955-5 2015 Moreover, treatment of macrophages with 15d-PGJ2, a natural PPAR-gamma ligand, significantly reduced Ang II-induced expression of Egr-1 and its inflammatory gene targets (IL-1beta, TNF-alpha, TGF-beta, MCP-1 and ICAM-1) through PPAR-gamma activation and ROS formation. 15-deoxyprostaglandin J2 40-48 C-C motif chemokine ligand 2 Homo sapiens 202-207 26136131-5 2015 Simvastatin, fenofibrate, and simvastatin/fenofibrate combination therapy reduced monocyte release of TNF-alpha, inteleukin-1beta, interleukin-6, and MCP-1, with no difference between the treatment groups. Simvastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 150-155 26136131-5 2015 Simvastatin, fenofibrate, and simvastatin/fenofibrate combination therapy reduced monocyte release of TNF-alpha, inteleukin-1beta, interleukin-6, and MCP-1, with no difference between the treatment groups. Fenofibrate 13-24 C-C motif chemokine ligand 2 Homo sapiens 150-155 26136131-5 2015 Simvastatin, fenofibrate, and simvastatin/fenofibrate combination therapy reduced monocyte release of TNF-alpha, inteleukin-1beta, interleukin-6, and MCP-1, with no difference between the treatment groups. Simvastatin 30-41 C-C motif chemokine ligand 2 Homo sapiens 150-155 26136131-5 2015 Simvastatin, fenofibrate, and simvastatin/fenofibrate combination therapy reduced monocyte release of TNF-alpha, inteleukin-1beta, interleukin-6, and MCP-1, with no difference between the treatment groups. Fenofibrate 42-53 C-C motif chemokine ligand 2 Homo sapiens 150-155 26136131-7 2015 The effect of simvastatin/fenofibrate combination therapy on monocyte release of interleukin-6 and MCP-1 was more pronounced in the male population. Simvastatin 14-25 C-C motif chemokine ligand 2 Homo sapiens 99-104 26136131-7 2015 The effect of simvastatin/fenofibrate combination therapy on monocyte release of interleukin-6 and MCP-1 was more pronounced in the male population. Fenofibrate 26-37 C-C motif chemokine ligand 2 Homo sapiens 99-104 24958127-0 2015 Ghrelin augments the expressions and secretions of proinflammatory adipokines, VEGF120 and MCP-1, in differentiated 3T3-L1 adipocytes. Ghrelin 0-7 C-C motif chemokine ligand 2 Homo sapiens 91-96 25139172-4 2015 In general terms, non-flavonoid polyphenols reduce the production of inflammatory mediators, such as IL-1beta, IL-8, MCP-1, COX-2 or iNOS in these animal models of diabetes. Polyphenols 32-43 C-C motif chemokine ligand 2 Homo sapiens 117-122 25055998-7 2015 We also found that poly-IC-induced mRNA expression of other proinflammatory mediators such as MCP-1, RANTES, and IL-8 was suppressed by licochalcone A. Poly I-C 19-26 C-C motif chemokine ligand 2 Homo sapiens 94-99 25055998-7 2015 We also found that poly-IC-induced mRNA expression of other proinflammatory mediators such as MCP-1, RANTES, and IL-8 was suppressed by licochalcone A. licochalcone 136-148 C-C motif chemokine ligand 2 Homo sapiens 94-99 25586482-0 2015 Propofol Attenuates Lipopolysaccharide-Induced Monocyte Chemoattractant Protein-1 Production Through Enhancing apoM and foxa2 Expression in HepG2 Cells. Propofol 0-8 C-C motif chemokine ligand 2 Homo sapiens 47-81 25586482-3 2015 However, the effect and possible mechanisms of propofol on MCP-1 expression remain unclear. Propofol 47-55 C-C motif chemokine ligand 2 Homo sapiens 59-64 25586482-6 2015 We found that propofol markedly decreased both MCP-1 messenger RNA (mRNA) and protein levels in LPS-stimulated HepG2 cells in a time-dependent manner. Propofol 14-22 C-C motif chemokine ligand 2 Homo sapiens 47-52 25586482-8 2015 In addition, the inhibitory effect of propofol on MCP-1 expression was significantly abolished by small interfering RNA against apoM and foxa2 in LPS-stimulated HepG2 cells. Propofol 38-46 C-C motif chemokine ligand 2 Homo sapiens 50-55 25586482-9 2015 Propofol attenuates LPS-induced MCP-1 production through enhancing apoM and foxa2 expression in HepG2 cells. Propofol 0-8 C-C motif chemokine ligand 2 Homo sapiens 32-37 24958127-7 2015 Furthermore, the treatment with LY294002 (50 mumol/L) and Wortmannin (10nmol/L), inhibitors of phosphatidylinositol 3-kinase (PI3K), significantly decreased the amplified VEGF(120) secretion by 29% (p < 0.01) and 28% (p < 0.01) relative to the cells stimulated by ghrelin alone, respectively, whereas these inhibitors had no effects on increased MCP-1 release. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 32-40 C-C motif chemokine ligand 2 Homo sapiens 352-357 24958127-7 2015 Furthermore, the treatment with LY294002 (50 mumol/L) and Wortmannin (10nmol/L), inhibitors of phosphatidylinositol 3-kinase (PI3K), significantly decreased the amplified VEGF(120) secretion by 29% (p < 0.01) and 28% (p < 0.01) relative to the cells stimulated by ghrelin alone, respectively, whereas these inhibitors had no effects on increased MCP-1 release. Wortmannin 58-68 C-C motif chemokine ligand 2 Homo sapiens 352-357 24958127-8 2015 On the other hand, JNK inhibitor SP600125 (10 mumol/L) clearly reduced the increased MCP-1, but not VEGF(120), release by 35% relative to the only ghrelin-stimulated cells (p < 0.01). pyrazolanthrone 33-41 C-C motif chemokine ligand 2 Homo sapiens 85-90 24958127-9 2015 In conclusion, ghrelin can enhance the secretions of proinflammatory adipokines, VEGF(120) and MCP-1, but fails to affect IL-10 and adiponectin which are considered to be anti-inflammatory adipokines. Ghrelin 15-22 C-C motif chemokine ligand 2 Homo sapiens 95-100 25653476-9 2015 Furthermore, rapamycin decreased PA-induced nuclear translocation of NFkappaB P65 subunit, thereby NFkappaB-dependent inflammatory cytokines MCP-1 and IL-6 expression and secretion. Sirolimus 13-22 C-C motif chemokine ligand 2 Homo sapiens 141-146 26084792-6 2015 The MCP-1 values were reduced by -28% in the patients treated with pitavastatin and only -11% in those treated with atorvastatin (p=0.016). pitavastatin 67-79 C-C motif chemokine ligand 2 Homo sapiens 4-9 26084792-6 2015 The MCP-1 values were reduced by -28% in the patients treated with pitavastatin and only -11% in those treated with atorvastatin (p=0.016). Atorvastatin 116-128 C-C motif chemokine ligand 2 Homo sapiens 4-9 26016511-5 2015 RESULTS: When HUVEC were exposed to PA, there was an increase in the expression of adhesion molecule, cytokines, and inflammatory protein (ICAM-1, MCP-1, interleukin-6, PTX3). Palmitic Acid 36-38 C-C motif chemokine ligand 2 Homo sapiens 147-152 26016511-8 2015 In addition, p21 knockdown suppressed the PA-induced increase in the expression of MCP-1 and ICAM-1. Palmitic Acid 42-44 C-C motif chemokine ligand 2 Homo sapiens 83-88 26016511-9 2015 EPA suppressed the PA-induced increase in the expression of ACSL and p21, the enhancement of p65 phosphorylation, as well as the associated increase in the expression of ICAM-1, MCP-1, interleukin-6, and PTX3. Palmitic Acid 1-3 C-C motif chemokine ligand 2 Homo sapiens 178-183 25653476-9 2015 Furthermore, rapamycin decreased PA-induced nuclear translocation of NFkappaB P65 subunit, thereby NFkappaB-dependent inflammatory cytokines MCP-1 and IL-6 expression and secretion. Palmitates 33-35 C-C motif chemokine ligand 2 Homo sapiens 141-146 26556954-3 2015 RAFLS incubated with CoCl2, but not S1P, produced less IL-8 and MCP-1 than normal FLS. cobaltous chloride 21-26 C-C motif chemokine ligand 2 Homo sapiens 64-69 26294848-7 2015 Hi-oxLDL induced mannose receptor expression and production of IL-6 and monocyte chemoattractant protein-1, which mostly match the phenotype of M2 macrophages. hi-oxldl 0-8 C-C motif chemokine ligand 2 Homo sapiens 72-106 24828014-7 2014 RESULTS: After 8 weeks of risperidone treatment, 2 of the 27 plasma cytokines showed statistically significant decreases in median levels: Eotaxin (p=0.0003) and monocyte chemoattractant protein-1 (MCP-1) (p=0.0024). Risperidone 26-37 C-C motif chemokine ligand 2 Homo sapiens 162-196 26335292-3 2015 MCP1 2518 A/G genotype was identified by PCR-RFLP in 60 biopsy-proven FSGS patients, 76 steroid sensitive nephrotic syndrome (SSNS) patients, and 96 healthy children. Steroids 88-95 C-C motif chemokine ligand 2 Homo sapiens 0-4 26335292-7 2015 Serum MCP-1 levels were similar in all groups, whereas urinary MCP-1 levels of the patients with FSGS (1680 pg/mg creatinine) were significantly higher than that of patients with SSNS (365 pg/mg creatinine, p < 0.05) and healthy controls (348 pg/mg creatinine; p < 0.05). Creatinine 114-124 C-C motif chemokine ligand 2 Homo sapiens 63-68 25457841-4 2014 Increased levels of CCL22, CXCL10 and sCD40L characterized relapsing-remitting MS patients with the presence of gadolinium-enhancing lesions; decreased CCL2 and increased CXCL1 and CCL5 were typical of relapsing-remitting MS patients irrespectively of the presence of gadolinium-enhancing lesions. Gadolinium 112-122 C-C motif chemokine ligand 2 Homo sapiens 20-24 25474105-8 2014 Ramipril reduces mRNA expression of multiple pro-inflammatory cytokines such as IL-1beta, IL-6, IL-8, TNF -alpha, Interferon-[Formula: see text], and MCP-1, as well as aortic wall IL-8 and MCP-1 (P = 0.017 and 0.008, respectively) protein content. Ramipril 0-8 C-C motif chemokine ligand 2 Homo sapiens 150-155 25474105-8 2014 Ramipril reduces mRNA expression of multiple pro-inflammatory cytokines such as IL-1beta, IL-6, IL-8, TNF -alpha, Interferon-[Formula: see text], and MCP-1, as well as aortic wall IL-8 and MCP-1 (P = 0.017 and 0.008, respectively) protein content. Ramipril 0-8 C-C motif chemokine ligand 2 Homo sapiens 189-194 25251945-6 2014 The beta-glucan-consisting glycans curdlan and zymosan stimulated IL-8 and CCL2 secretion by IEC lines. beta-Glucans 4-15 C-C motif chemokine ligand 2 Homo sapiens 75-79 25251945-6 2014 The beta-glucan-consisting glycans curdlan and zymosan stimulated IL-8 and CCL2 secretion by IEC lines. Polysaccharides 27-34 C-C motif chemokine ligand 2 Homo sapiens 75-79 25251945-6 2014 The beta-glucan-consisting glycans curdlan and zymosan stimulated IL-8 and CCL2 secretion by IEC lines. Zymosan 47-54 C-C motif chemokine ligand 2 Homo sapiens 75-79 25201328-7 2014 RESULTS: IL-1Ra, IL-6, IL-8, IL-10, IL-15, and MCP-1 were significantly elevated in the PTAA group. ptaa 88-92 C-C motif chemokine ligand 2 Homo sapiens 47-52 24828014-9 2014 CONCLUSIONS: Two cytokines, eotaxin and MCP-1, which have previously been identified as abnormally elevated in children with autism, decreased during treatment with risperidone. Risperidone 165-176 C-C motif chemokine ligand 2 Homo sapiens 40-45 25490414-4 2014 Pitavastatin also prevented the enhancement of the LPC content in LDL and the expression of MCP-1 mRNA when TNFalpha-stimulated HUVECs were incubated with LDL. pitavastatin 0-12 C-C motif chemokine ligand 2 Homo sapiens 92-97 26783382-5 2015 Addition of 40 mM NaCl significantly induced IL-6 and MCP-1 production but had no effect on IL-8 secretion. Sodium Chloride 18-22 C-C motif chemokine ligand 2 Homo sapiens 54-59 26539255-6 2015 RESULTS: UA significantly increased the expressions of IL-6, ICAM-1, TNF-alpha, and MCP-1 and the production of ROS in HUVEC. Uric Acid 9-11 C-C motif chemokine ligand 2 Homo sapiens 84-89 25477254-3 2014 The report shows that JW133 inhibits expression of the CCL2 cytokine, osteoclastogenesis and reduces histological indicators of joint degeneration. jw133 22-27 C-C motif chemokine ligand 2 Homo sapiens 55-59 25463072-7 2014 RESULTS: In separate SMC and monocyte cultures (monocultures) 25-hydroxycholesterol only poorly activated IL-1, IL-6 and MCP-1 production, whereas LPS stimulated much higher cytokine levels than unstimulated cultures. 25-hydroxycholesterol 62-83 C-C motif chemokine ligand 2 Homo sapiens 121-126 25463072-9 2014 Blocking experiments with IL-1-receptor antagonist showed that IL-1 decisively contributed to the 25-hydroxycholesterol-induced synergistic IL-6 and MCP-1 production. Hydroxycholesterols 101-119 C-C motif chemokine ligand 2 Homo sapiens 149-154 25145982-9 2014 The higher magnitude of metabolic demand reflected in higher lactate response in HYP could be the reason for the significantly high responses in WBC, IL-1ra and decrease in MCP-1. Lactic Acid 61-68 C-C motif chemokine ligand 2 Homo sapiens 173-178 25384214-6 2014 TANs produced substantial quantities of the proinflammatory factors MCP-1, IL-8, MIP-1alpha, and IL-6, as well as the antiinflammatory IL-1R antagonist. tans 0-4 C-C motif chemokine ligand 2 Homo sapiens 68-73 24828014-7 2014 RESULTS: After 8 weeks of risperidone treatment, 2 of the 27 plasma cytokines showed statistically significant decreases in median levels: Eotaxin (p=0.0003) and monocyte chemoattractant protein-1 (MCP-1) (p=0.0024). Risperidone 26-37 C-C motif chemokine ligand 2 Homo sapiens 198-203 25283329-4 2014 Palmitate enhanced ceramide accumulation and stimulated the expression and secretion of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) in L1. Palmitates 0-9 C-C motif chemokine ligand 2 Homo sapiens 113-147 25283329-4 2014 Palmitate enhanced ceramide accumulation and stimulated the expression and secretion of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) in L1. Palmitates 0-9 C-C motif chemokine ligand 2 Homo sapiens 149-154 25283329-10 2014 Myriocin or fumonisin B1 significantly lowered these cytokine levels and suppressed the gene expression of TNF-alpha and MCP-1 in RAW and of IL-6 and MCP-1 in L1. thermozymocidin 0-8 C-C motif chemokine ligand 2 Homo sapiens 121-126 25283329-10 2014 Myriocin or fumonisin B1 significantly lowered these cytokine levels and suppressed the gene expression of TNF-alpha and MCP-1 in RAW and of IL-6 and MCP-1 in L1. thermozymocidin 0-8 C-C motif chemokine ligand 2 Homo sapiens 150-155 25283329-10 2014 Myriocin or fumonisin B1 significantly lowered these cytokine levels and suppressed the gene expression of TNF-alpha and MCP-1 in RAW and of IL-6 and MCP-1 in L1. fumonisin B1 12-24 C-C motif chemokine ligand 2 Homo sapiens 121-126 25283329-10 2014 Myriocin or fumonisin B1 significantly lowered these cytokine levels and suppressed the gene expression of TNF-alpha and MCP-1 in RAW and of IL-6 and MCP-1 in L1. fumonisin B1 12-24 C-C motif chemokine ligand 2 Homo sapiens 150-155 25409333-12 2014 IL-10, MCP-1, and TNF were significantly increased in animals treated with LiCl compared to NaCl. Lithium Chloride 75-79 C-C motif chemokine ligand 2 Homo sapiens 7-12 24996906-10 2014 However, total cholesterol levels in the upper normal range were associated with systolic (r = -0.56, P < 0.01) and diastolic (r = -0.64, P < 0.001) dysfunction and with high eotaxin and MCP-1 (r = 0.56 and r = 0.50, P < 0.01) in patients with active disease, but not in those with inactive disease or in controls (all r < +-0.2). Cholesterol 15-26 C-C motif chemokine ligand 2 Homo sapiens 193-198 24996906-12 2014 In those with active disease and cholesterol levels in the upper normal range, eotaxin and MCP-1 might enhance susceptibility to cardiac dysfunction. Cholesterol 33-44 C-C motif chemokine ligand 2 Homo sapiens 91-96 25734173-13 2014 Baseline BDG concentrations correlated with CSF fungal burden (rho = 0.820; P < .001), CSF CRAG lateral flow assay titers (rho = 0.780, P < .001), and monocyte chemotactic protein-1 levels in CSF (P = .047). O(6)-n-butyldeoxyguanosine 9-12 C-C motif chemokine ligand 2 Homo sapiens 157-187 25271060-7 2014 We demonstrate that THP-1 cells rapidly secrete ATP during signalling downstream of the CCL2-CCR2 axis and suggest this might act as a mechanism for P2Y6 receptor co-activation following CCL2 activation of the CCR2 receptor. Adenosine Triphosphate 48-51 C-C motif chemokine ligand 2 Homo sapiens 88-92 25135357-2 2014 At molecular level, GSNO effects have been shown to modulate the activity of a series of transcription factors (notably NF-kappaB, AP-1, CREB and others) as well as other components of signal transduction chains (e.g. IKK-beta, caspase 1, calpain and others), resulting in the modulation of several cytokines and chemokines expression (TNFalpha, IL-1beta, IFN-gamma, IL-4, IL-8, RANTES, MCP-1 and others). S-Nitrosoglutathione 20-24 C-C motif chemokine ligand 2 Homo sapiens 387-392 25271060-7 2014 We demonstrate that THP-1 cells rapidly secrete ATP during signalling downstream of the CCL2-CCR2 axis and suggest this might act as a mechanism for P2Y6 receptor co-activation following CCL2 activation of the CCR2 receptor. Adenosine Triphosphate 48-51 C-C motif chemokine ligand 2 Homo sapiens 187-191 25381355-0 2014 Response to Comment on "Thiamine deficiency promotes T cell infiltration in experimental autoimmune encephalomyelitis: the involvement of CCL2". Thiamine 24-32 C-C motif chemokine ligand 2 Homo sapiens 138-142 24639403-6 2014 RESULTS: Although bolus and basal insulin doses were almost unchanged before and after replacement therapy, switching to glulisine insulin for 24 weeks significantly decreased level of HbA1c , advanced glycation end products (AGEs), soluble receptor for AGEs (sRAGE), monocyte chemoattractant protein-1 (MCP-1) and urinary albumin excretion. glulisine 121-130 C-C motif chemokine ligand 2 Homo sapiens 268-302 25234816-8 2014 Although monocyte chemoattractant protein-1 levels were not significantly higher than controls either under cocaine or PFP stimulation, atorvastatin completely avoided monocyte chemoattractant protein-1 release in both conditions. Atorvastatin 136-148 C-C motif chemokine ligand 2 Homo sapiens 168-202 24639403-6 2014 RESULTS: Although bolus and basal insulin doses were almost unchanged before and after replacement therapy, switching to glulisine insulin for 24 weeks significantly decreased level of HbA1c , advanced glycation end products (AGEs), soluble receptor for AGEs (sRAGE), monocyte chemoattractant protein-1 (MCP-1) and urinary albumin excretion. glulisine 121-130 C-C motif chemokine ligand 2 Homo sapiens 304-309 25331390-11 2014 CONCLUSION: The API, FMD and plasma levels of MCP-1 of hypercholesterolemia patients without clear coronary heart disease can be improved by simvastatin treatment. Simvastatin 141-152 C-C motif chemokine ligand 2 Homo sapiens 46-51 25263500-6 2014 Serum sKlotho levels negatively correlated with UACR, TG, CHO, LDL, 8-Iso-PGF2alpha, MCP-1, TNF-alpha, TGF-beta1 (P < 0.001), but positively correlated with LDL (P < 0.001). sklotho 6-13 C-C motif chemokine ligand 2 Homo sapiens 85-90 24952412-6 2014 RESULTS: Lidocaine (>=2 mug/mL) significantly inhibited the release and expression of nitric oxide, monocyte chemotactic protein 1, prostaglandin E2, interleukin 1beta, and tumor necrosis factor alpha in LPS-activated microglia. Lidocaine 9-18 C-C motif chemokine ligand 2 Homo sapiens 103-133 24737200-7 2014 Serum enhanced silica-induced interleukin (IL)-6, IL-10, IL-1beta and MCP-1 release, whereas albumin partially inhibited MCP-1 release. Silicon Dioxide 15-21 C-C motif chemokine ligand 2 Homo sapiens 70-75 24737200-8 2014 Aminated silica, 50 nm was more potent than the 200-nm particles at inducing monocyte chemoattractant protein-1 (MCP-1) production when dispersed in medium or LLF, suggesting a size specific effect for these particles and this cytokine. Silicon Dioxide 9-15 C-C motif chemokine ligand 2 Homo sapiens 77-111 24737200-8 2014 Aminated silica, 50 nm was more potent than the 200-nm particles at inducing monocyte chemoattractant protein-1 (MCP-1) production when dispersed in medium or LLF, suggesting a size specific effect for these particles and this cytokine. Silicon Dioxide 9-15 C-C motif chemokine ligand 2 Homo sapiens 113-118 25165111-8 2014 The application of minocycline, an inhibitor of neuroinflammation, altered the WNV-induced proinflammatory cytokine/chemokine expression profile, with inhibited production of CCL5, CCL2, and IL-6. Minocycline 19-30 C-C motif chemokine ligand 2 Homo sapiens 181-185 25164482-2 2014 It was found that under anaerobic conditions, the substrate CCl4 might undergo one or two subsequent one-electron reductions to generate different reactive metabolites, trichloromethyl radical ( CCl3) and dichlorocarbene (:CCl2) respectively. trichloromethyl free radical 169-192 C-C motif chemokine ligand 2 Homo sapiens 223-227 25164482-2 2014 It was found that under anaerobic conditions, the substrate CCl4 might undergo one or two subsequent one-electron reductions to generate different reactive metabolites, trichloromethyl radical ( CCl3) and dichlorocarbene (:CCl2) respectively. dichlorocarbene 205-220 C-C motif chemokine ligand 2 Homo sapiens 223-227 25053617-5 2014 Moreover, MCP-1 promoted the engagement of Galphai1, Galpha13, Galphaz, and betaarrestin2 to the heterooligomer, resulting in calcium signaling that was synergistically potentiated on coactivation of CCR2 and CXCR4, demonstrating that complexes larger than dimers reach the cell surface as functional units. Calcium 126-133 C-C motif chemokine ligand 2 Homo sapiens 10-15 25299192-6 2014 Isoprenaline or a beta-AR blocker could mediate through beta2-AR, affecting MCP-1 secretion, CCR2 protein expression and cell migration capacity of THP-1 cells. Isoproterenol 0-12 C-C motif chemokine ligand 2 Homo sapiens 76-81 24991787-7 2014 In type 2 diabetic subjects, overall positive correlation was found between total cholesterol or LDL serum concentration and MCP-1 serum level. Cholesterol 82-93 C-C motif chemokine ligand 2 Homo sapiens 125-130 26461414-9 2014 Very recently, it has been demonstrated that the inhibition of LXRalpha by 22-s-HC dramatically represses steatosis and HIF-1 mediated activation of MCP-1 in ethanol-induced fatty liver injury in hepatocytes as well as in Kupferr cells. 22-s-hc 75-82 C-C motif chemokine ligand 2 Homo sapiens 149-154 26461414-9 2014 Very recently, it has been demonstrated that the inhibition of LXRalpha by 22-s-HC dramatically represses steatosis and HIF-1 mediated activation of MCP-1 in ethanol-induced fatty liver injury in hepatocytes as well as in Kupferr cells. Ethanol 158-165 C-C motif chemokine ligand 2 Homo sapiens 149-154 25324951-10 2014 CONCLUSIONS: The urinary MCP-1/Cr ratio is significantly elevated in neonates with severe obstruction requiring surgical intervention. Chromium 31-33 C-C motif chemokine ligand 2 Homo sapiens 25-30 25023776-0 2014 Unfractionated heparin suppresses lipopolysaccharide-induced monocyte chemoattractant protein-1 expression in human microvascular endothelial cells by blocking Kruppel-like factor 5 and nuclear factor-kappaB pathway. Heparin 15-22 C-C motif chemokine ligand 2 Homo sapiens 61-95 25064633-11 2014 CONCLUSION: Curcumin suppresses MCP-1 production induced by ox-LDL via the JNK pathway and NK-kappaB pathway, while enhances cholesterol efflux in macrophage via suppressing the JNK pathway and activating the LXR-ABCA1/SR-BI pathway, which indicate that the vascular protective effect of curcumin is related to anti-inflammation and anti-atherosclerosis. Curcumin 12-20 C-C motif chemokine ligand 2 Homo sapiens 32-37 25151996-6 2014 RESULTS: CAPE inhibited the expression of IL-6, MCP-1 and ICAM-1 induced by the pro-inflammatory cytokine IL-1beta in corneal fibroblasts. caffeic acid phenethyl ester 9-13 C-C motif chemokine ligand 2 Homo sapiens 48-53 25064633-0 2014 Curcumin inhibits monocyte chemoattractant protein-1 expression and enhances cholesterol efflux by suppressing the c-Jun N-terminal kinase pathway in macrophage. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 18-52 25064633-1 2014 OBJECTIVE: To investigate the effect of curcumin on monocyte chemoattractant protein 1 (MCP-1) production and reverse cholesterol transport (RCT) in macrophage induced by oxidation low-density lipoprotein (ox-LDL), and to identify the signal pathways involved. Curcumin 40-48 C-C motif chemokine ligand 2 Homo sapiens 52-86 25064633-1 2014 OBJECTIVE: To investigate the effect of curcumin on monocyte chemoattractant protein 1 (MCP-1) production and reverse cholesterol transport (RCT) in macrophage induced by oxidation low-density lipoprotein (ox-LDL), and to identify the signal pathways involved. Curcumin 40-48 C-C motif chemokine ligand 2 Homo sapiens 88-93 25064633-6 2014 RESULTS: Curcumin decreased the production of MCP-1 induced by ox-LDL in macrophages. Curcumin 9-17 C-C motif chemokine ligand 2 Homo sapiens 46-51 25064633-7 2014 MCP-1 expression was restrained by the inhibition of c-Jun N-terminal kinase (JNK) pathway (SP600125) and NF-kappaB pathway (BAY11-7082). pyrazolanthrone 92-100 C-C motif chemokine ligand 2 Homo sapiens 0-5 24184699-0 2014 CCL2 induction by 1,25(OH)2D3 in dendritic cells from healthy donors and multiple sclerosis patients. Calcitriol 18-29 C-C motif chemokine ligand 2 Homo sapiens 0-4 24184699-4 2014 In this study we analyzed the role of 1,25(OH)2D3, the bioactive vitamin D metabolite, in the regulation of CCL2 expression by dendritic cells (DC) obtained from healthy donors and relapsing-remitting MS patients. Calcitriol 38-49 C-C motif chemokine ligand 2 Homo sapiens 108-112 24184699-4 2014 In this study we analyzed the role of 1,25(OH)2D3, the bioactive vitamin D metabolite, in the regulation of CCL2 expression by dendritic cells (DC) obtained from healthy donors and relapsing-remitting MS patients. Vitamin D 65-74 C-C motif chemokine ligand 2 Homo sapiens 108-112 24184699-5 2014 We report that 1,25(OH)2D3, as well as 25OHD3, its main blood precursor, induce the secretion of high levels of CCL2. Calcitriol 15-26 C-C motif chemokine ligand 2 Homo sapiens 112-116 24184699-7 2014 Moreover, we observed that 1,25(OH)2D3 is able to induce a significant CCL2 secretion in DC obtained from relapsing-remitting MS patients, although CCL2 levels in these latter are lower with respect to healthy controls. Calcitriol 27-38 C-C motif chemokine ligand 2 Homo sapiens 71-75 24184699-9 2014 However, we propose CCL2 as a molecular player contributing to the immunomodulatory activity of 1,25(OH)2D3 on DC, and hypothesize a role for this chemokine in the response of MS patients to vitamin D therapy. Calcitriol 96-107 C-C motif chemokine ligand 2 Homo sapiens 20-24 24184871-5 2014 Adding 25(OH)D3 to monocytes cultured in vitamin D-deficient serum or media decreased monocyte adhesion to fibronectin and migration stimulated by monocyte chemotactic protein 1 (MCP-1). Calcifediol 7-15 C-C motif chemokine ligand 2 Homo sapiens 147-177 24184871-5 2014 Adding 25(OH)D3 to monocytes cultured in vitamin D-deficient serum or media decreased monocyte adhesion to fibronectin and migration stimulated by monocyte chemotactic protein 1 (MCP-1). Calcifediol 7-15 C-C motif chemokine ligand 2 Homo sapiens 179-184 24184871-5 2014 Adding 25(OH)D3 to monocytes cultured in vitamin D-deficient serum or media decreased monocyte adhesion to fibronectin and migration stimulated by monocyte chemotactic protein 1 (MCP-1). Vitamin D 41-50 C-C motif chemokine ligand 2 Homo sapiens 147-177 24184871-5 2014 Adding 25(OH)D3 to monocytes cultured in vitamin D-deficient serum or media decreased monocyte adhesion to fibronectin and migration stimulated by monocyte chemotactic protein 1 (MCP-1). Vitamin D 41-50 C-C motif chemokine ligand 2 Homo sapiens 179-184 25044948-0 2014 Docosahexaenoic acid reduces linoleic acid induced monocyte chemoattractant protein-1 expression via PPARgamma and nuclear factor-kappaB pathway in retinal pigment epithelial cells. Docosahexaenoic Acids 0-20 C-C motif chemokine ligand 2 Homo sapiens 51-85 25044948-0 2014 Docosahexaenoic acid reduces linoleic acid induced monocyte chemoattractant protein-1 expression via PPARgamma and nuclear factor-kappaB pathway in retinal pigment epithelial cells. Linoleic Acid 29-42 C-C motif chemokine ligand 2 Homo sapiens 51-85 25044948-1 2014 SCOPE: To investigate whether docosahexaenoic acid (DHA) could inhibit linoleic acid (LA) induced monocyte chemoattractant protein (MCP)-1 expression in human retinal pigment epithelial (RPE) cells. Docosahexaenoic Acids 30-50 C-C motif chemokine ligand 2 Homo sapiens 98-138 24816187-3 2014 Elevated CCL2 expression was found in three non-MDR paclitaxel resistant ovarian cancer lines ES-2/TP, MES-OV/TP and OVCAR-3/TP, compared to parental cells. Paclitaxel 52-62 C-C motif chemokine ligand 2 Homo sapiens 9-13 24816187-3 2014 Elevated CCL2 expression was found in three non-MDR paclitaxel resistant ovarian cancer lines ES-2/TP, MES-OV/TP and OVCAR-3/TP, compared to parental cells. 2-(N-morpholino)ethanesulfonic acid 103-106 C-C motif chemokine ligand 2 Homo sapiens 9-13 25229495-9 2014 Urinary MCP1 correlated negatively with 25(OH)D (r = -0.53, p = 0.003) and positively with serum deoxypyridinoline (r = 0.53, p = 0.004). deoxypyridinoline 97-114 C-C motif chemokine ligand 2 Homo sapiens 8-12 25060177-5 2014 The results showed that the concentration of CCL2 in the OSCC group was significantly lower compared to that in the healthy controls (67.81 vs. 108.1 pg/ml, P < 0.0001). oscc 57-61 C-C motif chemokine ligand 2 Homo sapiens 45-49 25044948-1 2014 SCOPE: To investigate whether docosahexaenoic acid (DHA) could inhibit linoleic acid (LA) induced monocyte chemoattractant protein (MCP)-1 expression in human retinal pigment epithelial (RPE) cells. Docosahexaenoic Acids 52-55 C-C motif chemokine ligand 2 Homo sapiens 98-138 25044948-1 2014 SCOPE: To investigate whether docosahexaenoic acid (DHA) could inhibit linoleic acid (LA) induced monocyte chemoattractant protein (MCP)-1 expression in human retinal pigment epithelial (RPE) cells. Linoleic Acid 71-84 C-C motif chemokine ligand 2 Homo sapiens 98-138 25044948-5 2014 DHA at 50 and 100 muM effectively inhibited LA-induced MCP-1 expression and production (p < 0.05) and NF-kappaB activation. Docosahexaenoic Acids 0-3 C-C motif chemokine ligand 2 Homo sapiens 55-60 25044948-9 2014 CONCLUSION: DHA reduced LA-induced MCP-1 expression via a PPARgamma- and NF-kappaB-dependent pathway in ARPE-19 cells. Docosahexaenoic Acids 12-15 C-C motif chemokine ligand 2 Homo sapiens 35-40 25257976-8 2014 RESULTS: Sirolimus significantly suppressed the LPS-induced expression of MCP-1, IL-8, RANTES, MIP-1alpha, and MIP-1beta in the THP-1 cells and human primary monocytes. Sirolimus 9-18 C-C motif chemokine ligand 2 Homo sapiens 74-79 25257976-11 2014 CONCLUSION: Sirolimus downregulates the expression of chemokines in monocytes, including MCP-1, RANTES, IL-8, MIP-1alpha, and MIP-1beta, by inhibiting the NF-kappaB-p65 and MAPK-p38 signalling pathways. Sirolimus 12-21 C-C motif chemokine ligand 2 Homo sapiens 89-94 25153881-3 2014 These two malvidin glycosides could inhibit tumor necrosis factor-alpha (TNF-alpha) induced increases of monocyte chemotactic protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) production both in the protein and mRNA levels in a concentration-dependent manner. Glycosides 19-29 C-C motif chemokine ligand 2 Homo sapiens 105-135 24788844-5 2014 Significant differences were found in gender, age, fever days, white blood cell count, C-reactive protein level, blood glucose concentration, and CCL2 level among genotypes of CCL2-2510A/G in EV71-infected patients, but no significant differences were found in alanine aminotransferase, aspartate aminotransferase, or creatine kinase myocardial isozyme levels or in cerebrospinal fluid evaluations (except monocytes) in patients with EV71 encephalitis. Glucose 119-126 C-C motif chemokine ligand 2 Homo sapiens 176-180 25079671-6 2014 Glucose fluctuations were significantly improved by the change in treatment (M-value: 10.54 +- 4.32 to 8.36 +- 2.54), while serum protein concentrations of MCP-1 (525.04 +- 288.06-428.11 +- 163.78 pg/mL) and sE-selectin (18.65 +- 9.77-14.50 +- 6.26 ng/mL) were suppressed. se-selectin 208-219 C-C motif chemokine ligand 2 Homo sapiens 156-161 25079671-7 2014 CONCLUSION: Our results suggest that switching from acarbose or voglibose to miglitol for 3 months suppressed glucose fluctuations and serum protein levels of MCP-1 and sE-selectin in type 2 diabetic Japanese patients, with fewer adverse effects. Acarbose 52-60 C-C motif chemokine ligand 2 Homo sapiens 159-164 25079671-7 2014 CONCLUSION: Our results suggest that switching from acarbose or voglibose to miglitol for 3 months suppressed glucose fluctuations and serum protein levels of MCP-1 and sE-selectin in type 2 diabetic Japanese patients, with fewer adverse effects. voglibose 64-73 C-C motif chemokine ligand 2 Homo sapiens 159-164 25079671-7 2014 CONCLUSION: Our results suggest that switching from acarbose or voglibose to miglitol for 3 months suppressed glucose fluctuations and serum protein levels of MCP-1 and sE-selectin in type 2 diabetic Japanese patients, with fewer adverse effects. miglitol 77-85 C-C motif chemokine ligand 2 Homo sapiens 159-164 24477600-8 2014 Moreover, adenosine inhibited thrombin-induced elevated expression of proinflammatory cytokines, IL-6 and HMGB-1; and chemokines, MCP-1, CXCL-1, and CXCL-3. Adenosine 10-19 C-C motif chemokine ligand 2 Homo sapiens 130-135 24951966-13 2014 Last, we showed that fluvastatin reduced the mRNA levels of pro-inflammatory molecules such as IL-1beta and MCP-1 in LPS-treated macrophages, which were completely reversed by CSE inhibitor PAG. Fluvastatin 21-32 C-C motif chemokine ligand 2 Homo sapiens 108-113 24951966-13 2014 Last, we showed that fluvastatin reduced the mRNA levels of pro-inflammatory molecules such as IL-1beta and MCP-1 in LPS-treated macrophages, which were completely reversed by CSE inhibitor PAG. propargylglycine 190-193 C-C motif chemokine ligand 2 Homo sapiens 108-113 25226283-8 2014 Consequently, DCE and CS decreased the IL-22- and IFN-gamma-induced expression of inflammatory and regulatory genes in keratinocytes, including CCL2, CXCL10, ICAM-1 and SOCS3. costunolide 22-24 C-C motif chemokine ligand 2 Homo sapiens 144-148 25016365-7 2014 RESULTS: Irbesartan reduced concentrations of IL-6, IL-8, CCL2, CXCL5, OPG, OPN and CXCL16 in both atheroma and primary vascular cell culture supernatants. Irbesartan 9-19 C-C motif chemokine ligand 2 Homo sapiens 58-62 24928308-7 2014 Furthermore we could observe an increased expression and secretion of pro-inflammatory cytokines like interleukin (IL)-6, IL-8 and MCP-1 (2.5-, 2.4- and 1.5-fold, respectively) by the sDPP4 treatment. sdpp4 184-189 C-C motif chemokine ligand 2 Homo sapiens 131-136 25317018-9 2014 CoCl2 effectively reduced MCP-1 and RANTES production. cobaltous chloride 0-5 C-C motif chemokine ligand 2 Homo sapiens 26-31 25149422-7 2014 As a follow-up, we observed a significantly increased CCL2 production by WM-, but not GM-derived astrocytes upon stimulation with bz-ATP in vitro. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 130-136 C-C motif chemokine ligand 2 Homo sapiens 54-58 25149422-11 2014 We propose that the divergent expression of CCL2 and CCR2 in WML and GML explains or contributes to the differences in WML and GML formation in MS. dodecanoic acid;propane-1,2,3-triol 69-72 C-C motif chemokine ligand 2 Homo sapiens 44-48 25149422-11 2014 We propose that the divergent expression of CCL2 and CCR2 in WML and GML explains or contributes to the differences in WML and GML formation in MS. dodecanoic acid;propane-1,2,3-triol 127-130 C-C motif chemokine ligand 2 Homo sapiens 44-48 25142123-1 2014 BACKGROUND: We aimed to evaluate urinary MCP-1 and oxidative stress through urinary malondialdehyde (MDA) in leprosy and correlate them with traditional, but less sensitive markers of renal disease. Malondialdehyde 84-99 C-C motif chemokine ligand 2 Homo sapiens 41-46 25153881-3 2014 These two malvidin glycosides could inhibit tumor necrosis factor-alpha (TNF-alpha) induced increases of monocyte chemotactic protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) production both in the protein and mRNA levels in a concentration-dependent manner. Glycosides 19-29 C-C motif chemokine ligand 2 Homo sapiens 137-142 25153881-4 2014 Mv-3-glc at the concentration of 1 muM could inhibit 35.9% increased MCP-1, 54.4% ICAM-1, and 44.7% VCAM-1 protein in supernatant, as well as 9.88% MCP-1 and 48.6% ICAM-1 mRNA expression (p<0.05). mv-3-glc 0-8 C-C motif chemokine ligand 2 Homo sapiens 69-74 25153881-4 2014 Mv-3-glc at the concentration of 1 muM could inhibit 35.9% increased MCP-1, 54.4% ICAM-1, and 44.7% VCAM-1 protein in supernatant, as well as 9.88% MCP-1 and 48.6% ICAM-1 mRNA expression (p<0.05). mv-3-glc 0-8 C-C motif chemokine ligand 2 Homo sapiens 148-153 25000979-4 2014 We found that Ly6G(+) cells transmigrated more efficiently across lal(-/-) ECs than wild-type (lal(+/+)) ECs, which were associated with increased levels of PECAM-1 and MCP-1 in lal(-/-) ECs. ly6g 14-18 C-C motif chemokine ligand 2 Homo sapiens 169-174 25089120-7 2014 IPE secreted IL-8 or MCP-1 in response to Pam3CSK4.3HCl, Poly(I:C), LPS and MALP-2, whereas RPE produced IL-8 only after Poly(I:C), LPS or MALP-2 treatment. ipe 0-3 C-C motif chemokine ligand 2 Homo sapiens 21-26 24813355-8 2014 There was a positive relationship between serum MCP-1 and uric acid concentrations (r = 0.27, p < 0.05). Uric Acid 58-67 C-C motif chemokine ligand 2 Homo sapiens 48-53 25069913-8 2014 Gln also up-regulated expression of interleukin-6, interleukin-8, MCP-1, MIP-3alpha, CCL2, CCL20, and CXCL1. Glutamine 0-3 C-C motif chemokine ligand 2 Homo sapiens 66-71 25069913-8 2014 Gln also up-regulated expression of interleukin-6, interleukin-8, MCP-1, MIP-3alpha, CCL2, CCL20, and CXCL1. Glutamine 0-3 C-C motif chemokine ligand 2 Homo sapiens 85-89 25092091-0 2014 Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma. sphingosine 1-phosphate 47-70 C-C motif chemokine ligand 2 Homo sapiens 13-43 25092091-2 2014 Preliminary data derived from a human angiogenesis array in NB showed that the bioactive lipid sphingosine-1-phosphate (S1P) induced the secretion of several angiogenesis-related proteins including the important inflammatory factor chemokine (C-C motif) ligand 2 (CCL2). sphingosine 1-phosphate 95-118 C-C motif chemokine ligand 2 Homo sapiens 232-262 25092091-2 2014 Preliminary data derived from a human angiogenesis array in NB showed that the bioactive lipid sphingosine-1-phosphate (S1P) induced the secretion of several angiogenesis-related proteins including the important inflammatory factor chemokine (C-C motif) ligand 2 (CCL2). sphingosine 1-phosphate 95-118 C-C motif chemokine ligand 2 Homo sapiens 264-268 25092091-8 2014 Blockade of S1P2 signaling using the selective S1P2 antagonist JTE-013 inhibited S1P-induced CCL2 expression. JTE 013 63-70 C-C motif chemokine ligand 2 Homo sapiens 93-97 25089120-7 2014 IPE secreted IL-8 or MCP-1 in response to Pam3CSK4.3HCl, Poly(I:C), LPS and MALP-2, whereas RPE produced IL-8 only after Poly(I:C), LPS or MALP-2 treatment. poly 57-61 C-C motif chemokine ligand 2 Homo sapiens 21-26 24972512-14 2014 MCP1 cytokine mRNA levels and secreted protein expression was significantly decreased by everolimus (10(-5) M) in FC. Everolimus 89-99 C-C motif chemokine ligand 2 Homo sapiens 0-4 24646773-0 2014 Elevated urinary CCL2: Cr at 6 months is associated with renal allograft interstitial fibrosis and inflammation at 24 months. Chromium 23-25 C-C motif chemokine ligand 2 Homo sapiens 17-21 24646773-1 2014 BACKGROUND: We have demonstrated that 6-month urinary CCL2: Cr is a predictor of interstitial fibrosis and tubular atrophy (IFTA) on 24-month biopsy and death-censored graft loss. Chromium 60-62 C-C motif chemokine ligand 2 Homo sapiens 54-58 24646773-1 2014 BACKGROUND: We have demonstrated that 6-month urinary CCL2: Cr is a predictor of interstitial fibrosis and tubular atrophy (IFTA) on 24-month biopsy and death-censored graft loss. ifta 124-128 C-C motif chemokine ligand 2 Homo sapiens 54-58 24646773-3 2014 As early CCL2: Cr predicts late graft loss, the goal of this study was to determine if 6-month urinary CCL2: Cr was a predictor of IF+i at 24 months. Chromium 109-111 C-C motif chemokine ligand 2 Homo sapiens 103-107 24646773-5 2014 RESULTS: Six-month urinary CCL2: Cr was significantly higher in IF+i and transplant glomerulopathy patients compared with normal histology at 24 months. Chromium 33-35 C-C motif chemokine ligand 2 Homo sapiens 27-31 24646773-6 2014 By multivariate analysis, 6-month urinary CCL2: Cr was independently correlated with IF+i at 24 months (OR 2.78, 95% CI 1.38-6.12, AUC 0.695, P=0.003). Chromium 48-50 C-C motif chemokine ligand 2 Homo sapiens 42-46 24646773-7 2014 Six-month urinary CCL2: Cr was also an independent correlate of 6-month IF+i (OR 1.99, 95% CI 1.03-4.18, AUC 0.63, P=0.04). Chromium 24-26 C-C motif chemokine ligand 2 Homo sapiens 18-22 24646773-8 2014 Six-month urinary CCL2: Cr distinguished noninflamed renal tissue (normal, fibrosis) from IF+i with a sensitivity/specificity of 0.71/0.62 at a cutoff of 15 ng CCL2/mmol Cr (AUC 0.695, P=0.003, n=91). Chromium 24-26 C-C motif chemokine ligand 2 Homo sapiens 18-22 24646773-8 2014 Six-month urinary CCL2: Cr distinguished noninflamed renal tissue (normal, fibrosis) from IF+i with a sensitivity/specificity of 0.71/0.62 at a cutoff of 15 ng CCL2/mmol Cr (AUC 0.695, P=0.003, n=91). Chromium 170-172 C-C motif chemokine ligand 2 Homo sapiens 18-22 24646773-9 2014 CONCLUSIONS: Urinary CCL2: Cr may be useful for the noninvasive identification of patients with or at risk for IF+i. Chromium 27-29 C-C motif chemokine ligand 2 Homo sapiens 21-25 24646773-11 2014 Furthermore, urinary CCL2: Cr may also identify individuals who may benefit from novel interventional trials targeting IF+i. Chromium 27-29 C-C motif chemokine ligand 2 Homo sapiens 21-25 24792438-4 2014 The silencing of MSKs with small-interfering RNAs and the pharmacological inhibitor of MSKs SB747651A shows a role for both MSK1 and MSK2 in LPA-mediated phosphorylation of CREB at Ser-133 and secretion of IL-8 and MCP-1. SB 747651A 92-101 C-C motif chemokine ligand 2 Homo sapiens 215-220 24792438-4 2014 The silencing of MSKs with small-interfering RNAs and the pharmacological inhibitor of MSKs SB747651A shows a role for both MSK1 and MSK2 in LPA-mediated phosphorylation of CREB at Ser-133 and secretion of IL-8 and MCP-1. lysophosphatidic acid 141-144 C-C motif chemokine ligand 2 Homo sapiens 215-220 24792438-4 2014 The silencing of MSKs with small-interfering RNAs and the pharmacological inhibitor of MSKs SB747651A shows a role for both MSK1 and MSK2 in LPA-mediated phosphorylation of CREB at Ser-133 and secretion of IL-8 and MCP-1. Serine 181-184 C-C motif chemokine ligand 2 Homo sapiens 215-220 24599781-7 2014 In addition, two inhibitors of CCL2 (L-Mimosine) were retrieved from the DrugBank database. Mimosine 37-47 C-C motif chemokine ligand 2 Homo sapiens 31-35 24874745-10 2014 Furthermore, orbital tissue was obtained from a patient with active GO, and the effect of dasatinib on the expression levels of HAS2-, CCL2-, IL6-, and IL8-mRNA expression was examined by real-time quantitative PCR. Dasatinib 90-99 C-C motif chemokine ligand 2 Homo sapiens 135-139 24874745-14 2014 In orbital tissue from active GO, dasatinib significantly suppressed HAS2-, CCL2-, IL6- and IL8-mRNA levels. Dasatinib 34-43 C-C motif chemokine ligand 2 Homo sapiens 76-80 24918924-5 2014 RESULTS: In HAEC, TLR4 antagonism with eritoran inhibited LPS-induced mRNA expression of IL-6, IL-8, TNFalpha, CCL-2, VCAM and ICAM (P<0.05 for all) and inhibited Ox-PAPC-induced mRNA expression of IL-8 (P<0.05) and IL-6, albeit not to a statistically significant level (p = 0.07). eritoran 39-47 C-C motif chemokine ligand 2 Homo sapiens 111-116 24727346-7 2014 Results showed that animals receiving OR486 exhibited higher levels of NO derivatives, tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and chemokine (C-C motif) ligand 2 (CCL2) in a beta2- and beta3AR-dependent manner. OR486 38-43 C-C motif chemokine ligand 2 Homo sapiens 183-213 24727346-7 2014 Results showed that animals receiving OR486 exhibited higher levels of NO derivatives, tumor necrosis factor alpha (TNFalpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and chemokine (C-C motif) ligand 2 (CCL2) in a beta2- and beta3AR-dependent manner. OR486 38-43 C-C motif chemokine ligand 2 Homo sapiens 215-219 24746987-5 2014 The 16-hour exposure to ZnO particles increased the level of monocyte chemotactic protein-1 (MCP-1) and induced the migration of THP-1 monocyte mediated by increased MCP-1. Zinc Oxide 24-27 C-C motif chemokine ligand 2 Homo sapiens 61-91 24746987-5 2014 The 16-hour exposure to ZnO particles increased the level of monocyte chemotactic protein-1 (MCP-1) and induced the migration of THP-1 monocyte mediated by increased MCP-1. Zinc Oxide 24-27 C-C motif chemokine ligand 2 Homo sapiens 93-98 24746987-5 2014 The 16-hour exposure to ZnO particles increased the level of monocyte chemotactic protein-1 (MCP-1) and induced the migration of THP-1 monocyte mediated by increased MCP-1. Zinc Oxide 24-27 C-C motif chemokine ligand 2 Homo sapiens 166-171 24980831-0 2014 Histone deacetylase inhibitor-temozolomide co-treatment inhibits melanoma growth through suppression of Chemokine (C-C motif) ligand 2-driven signals. Temozolomide 30-42 C-C motif chemokine ligand 2 Homo sapiens 104-134 24980831-6 2014 Co-incubation with a CCL2-blocking-antibody enhanced in vitro cell sensitivity to temozolomide. Temozolomide 82-94 C-C motif chemokine ligand 2 Homo sapiens 21-25 24980831-9 2014 By showing that down-regulation of CCL2-driven signals by SAHA and temozolomide via JNK contributes to reduce melanoma growth, we provide a rationale for the therapeutic advantage of the drug combination. Vorinostat 58-62 C-C motif chemokine ligand 2 Homo sapiens 35-39 24980831-9 2014 By showing that down-regulation of CCL2-driven signals by SAHA and temozolomide via JNK contributes to reduce melanoma growth, we provide a rationale for the therapeutic advantage of the drug combination. Temozolomide 67-79 C-C motif chemokine ligand 2 Homo sapiens 35-39 24967182-5 2014 RESULTS: EGCG pre-treatment significantly inhibited the secretion of TNF-alpha, VEGF, MCP-1 and NO in LPS-stimulated HRECs. epigallocatechin gallate 9-13 C-C motif chemokine ligand 2 Homo sapiens 86-91 24911931-0 2014 3T3-L1 preadipocytes exhibit heightened monocyte-chemoattractant protein-1 response to acute fatty acid exposure. acute fatty acid 87-103 C-C motif chemokine ligand 2 Homo sapiens 40-74 24911931-6 2014 Fatty acid exposure at 2 and 4 h increased both monocyte chemoattractant protein-1 and interleukin-6 gene expression levels in preadipocytes to greater levels than in mature adipocytes. Fatty Acids 0-10 C-C motif chemokine ligand 2 Homo sapiens 48-82 24495780-0 2014 A pharmacogenetic study of risperidone on chemokine (C-C motif) ligand 2 (CCL2) in Chinese Han schizophrenia patients. Risperidone 27-38 C-C motif chemokine ligand 2 Homo sapiens 42-72 24495780-4 2014 This investigation was attempted to clarify whether CCL2 polymorphism could affect risperidone efficacy. Risperidone 83-94 C-C motif chemokine ligand 2 Homo sapiens 52-56 24495780-0 2014 A pharmacogenetic study of risperidone on chemokine (C-C motif) ligand 2 (CCL2) in Chinese Han schizophrenia patients. Risperidone 27-38 C-C motif chemokine ligand 2 Homo sapiens 74-78 24495780-5 2014 We genotyped four SNPs (rs4795893, rs1024611, rs4586 and rs2857657) distributed throughout the CCL2 gene and examined them for association using the Positive and Negative Syndrome Scale (PANSS) score in two independent cohorts of Chinese schizophrenic patients (n = 208) from two different geographic areas, following an 8-week period of risperidone monotherapy. Risperidone 338-349 C-C motif chemokine ligand 2 Homo sapiens 95-99 24495780-7 2014 Our results indicate that there may be some effect of variations in the CCL2 gene on therapeutic efficacy of risperidone, and the associated polymorphisms may be a potential genetic marker for predicting the therapeutic effect of risperidone. Risperidone 109-120 C-C motif chemokine ligand 2 Homo sapiens 72-76 24531940-0 2014 A CCL2/ROS autoregulation loop is critical for cancer-associated fibroblasts-enhanced tumor growth of oral squamous cell carcinoma. Reactive Oxygen Species 7-10 C-C motif chemokine ligand 2 Homo sapiens 2-6 24495780-7 2014 Our results indicate that there may be some effect of variations in the CCL2 gene on therapeutic efficacy of risperidone, and the associated polymorphisms may be a potential genetic marker for predicting the therapeutic effect of risperidone. Risperidone 230-241 C-C motif chemokine ligand 2 Homo sapiens 72-76 24922637-0 2014 Diallyl disulfide inhibits TNFalpha-induced CCL2 release by MDA-MB-231 cells. diallyl disulfide 0-17 C-C motif chemokine ligand 2 Homo sapiens 44-48 24922637-4 2014 In the current study, we investigated the effects of the organosulfur compound diallyl disulfide (DADS), a natural constituent of Allium sativum (garlic) on suppression of TNFalpha-induced release of CCL2 from triple-negative human breast tumor (MDA-MB-231) cells. organosulfur 57-69 C-C motif chemokine ligand 2 Homo sapiens 200-204 24922637-4 2014 In the current study, we investigated the effects of the organosulfur compound diallyl disulfide (DADS), a natural constituent of Allium sativum (garlic) on suppression of TNFalpha-induced release of CCL2 from triple-negative human breast tumor (MDA-MB-231) cells. diallyl disulfide 79-96 C-C motif chemokine ligand 2 Homo sapiens 200-204 24922637-4 2014 In the current study, we investigated the effects of the organosulfur compound diallyl disulfide (DADS), a natural constituent of Allium sativum (garlic) on suppression of TNFalpha-induced release of CCL2 from triple-negative human breast tumor (MDA-MB-231) cells. diallyl disulfide 98-102 C-C motif chemokine ligand 2 Homo sapiens 200-204 24922637-7 2014 TNFalpha-induced CCL2 release was reversed by a sub-lethal concentration of DADS (100 muM), evident in antibody based assays. diallyl disulfide 76-80 C-C motif chemokine ligand 2 Homo sapiens 17-21 24443409-0 2014 Bisphosphonates inhibit osteosarcoma-mediated osteolysis via attenuation of tumor expression of MCP-1 and RANKL. Diphosphonates 0-15 C-C motif chemokine ligand 2 Homo sapiens 96-101 24714806-4 2014 Network analysis revealed strong negative correlations between the inflammatory markers CRP, TNF-alpha, resistin and MCP-1 and lipids in the LPC, PC and PE classes, whereas IL-8 formed positive correlations with lipids from the CER and SM classes. pc 142-144 C-C motif chemokine ligand 2 Homo sapiens 117-122 24661543-9 2014 H89 (PKA inhibitor) and sc-514 (IKKbeta inhibitor) each blocked TSH-stimulated MCP-1 mRNA expression and protein release, suggesting PKA and IKKbeta participate in this pathway. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide 0-3 C-C motif chemokine ligand 2 Homo sapiens 79-84 24661543-9 2014 H89 (PKA inhibitor) and sc-514 (IKKbeta inhibitor) each blocked TSH-stimulated MCP-1 mRNA expression and protein release, suggesting PKA and IKKbeta participate in this pathway. SC 514 24-30 C-C motif chemokine ligand 2 Homo sapiens 79-84 24661543-9 2014 H89 (PKA inhibitor) and sc-514 (IKKbeta inhibitor) each blocked TSH-stimulated MCP-1 mRNA expression and protein release, suggesting PKA and IKKbeta participate in this pathway. Thyrotropin 64-67 C-C motif chemokine ligand 2 Homo sapiens 79-84 24988089-5 2014 Ambient plasma glucose concentration showed a significant positive association with plasma MDA, oxLDL, MCP-1, and VCAM, and a significant inverse association with PON1 and ApoA1 in diabetic patients. Glucose 15-22 C-C motif chemokine ligand 2 Homo sapiens 103-108 24714806-4 2014 Network analysis revealed strong negative correlations between the inflammatory markers CRP, TNF-alpha, resistin and MCP-1 and lipids in the LPC, PC and PE classes, whereas IL-8 formed positive correlations with lipids from the CER and SM classes. pe 153-155 C-C motif chemokine ligand 2 Homo sapiens 117-122 24414608-10 2014 CONCLUSIONS: Urinary MCP-1/creatinine levels are elevated in the early stages of severe HSP nephritis and can be used as a biomarker for HSP nephritis. Creatinine 27-37 C-C motif chemokine ligand 2 Homo sapiens 21-26 24668612-0 2014 Elevated IL-8, TNF-alpha, and MCP-1 in men with metastatic prostate cancer starting androgen-deprivation therapy (ADT) are associated with shorter time to castration-resistance and overall survival. adt 114-117 C-C motif chemokine ligand 2 Homo sapiens 30-35 24891839-8 2014 Likewise, UAH and EAH showed a reduction in the expression of monocyte-chemo attractant protein-1 (MCP-1) (35% and 42%, respectively), transferrin receptor-1 (TfR-1) (48% and 61%, respectively), granulocyte-macrophage colony-stimulating factor (GM-CSF) (59% and 63%, respectively), and tumor necrosis factor-alpha (TNF-alpha) (60% and 63%, respectively). (5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate 10-13 C-C motif chemokine ligand 2 Homo sapiens 62-97 24891839-8 2014 Likewise, UAH and EAH showed a reduction in the expression of monocyte-chemo attractant protein-1 (MCP-1) (35% and 42%, respectively), transferrin receptor-1 (TfR-1) (48% and 61%, respectively), granulocyte-macrophage colony-stimulating factor (GM-CSF) (59% and 63%, respectively), and tumor necrosis factor-alpha (TNF-alpha) (60% and 63%, respectively). eah 18-21 C-C motif chemokine ligand 2 Homo sapiens 62-97 24891839-8 2014 Likewise, UAH and EAH showed a reduction in the expression of monocyte-chemo attractant protein-1 (MCP-1) (35% and 42%, respectively), transferrin receptor-1 (TfR-1) (48% and 61%, respectively), granulocyte-macrophage colony-stimulating factor (GM-CSF) (59% and 63%, respectively), and tumor necrosis factor-alpha (TNF-alpha) (60% and 63%, respectively). eah 18-21 C-C motif chemokine ligand 2 Homo sapiens 99-104 24879414-11 2014 Angiogenin, IGFBP-1, IL-8, MCP-1, MMP-9, and VEGF mRNA and protein expressions were significantly enhanced in LPA-treated chondrocytes. lysophosphatidic acid 110-113 C-C motif chemokine ligand 2 Homo sapiens 27-32 24879414-13 2014 Pretreatment with the Gi/o type G protein inhibitor, pertussis toxin (PTX), and the NF-kB inhibitor, PDTC, significantly inhibited LPA-induced angiogenin, IGFBP-1, IL-8, MCP-1, MMP-9, and VEGF expressions in chondrocytes. lysophosphatidic acid 131-134 C-C motif chemokine ligand 2 Homo sapiens 170-175 24891839-8 2014 Likewise, UAH and EAH showed a reduction in the expression of monocyte-chemo attractant protein-1 (MCP-1) (35% and 42%, respectively), transferrin receptor-1 (TfR-1) (48% and 61%, respectively), granulocyte-macrophage colony-stimulating factor (GM-CSF) (59% and 63%, respectively), and tumor necrosis factor-alpha (TNF-alpha) (60% and 63%, respectively). (5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate 10-13 C-C motif chemokine ligand 2 Homo sapiens 99-104 24605795-0 2014 Following the path of CCL2 from prostaglandins to periostin in lung fibrosis. Prostaglandins 32-46 C-C motif chemokine ligand 2 Homo sapiens 22-26 24885771-6 2014 In vitro macrophage exposure to representative NP (Fe2O3, Fe3O4, MnFe2O4 and CrOOH) induced the production of a pro-inflammatory secretome (increased production of CXCL-8, IL-1ss, TNF-alpha, CCL-2, -3, -4, and to a lesser extent IL-6, CCL-7 and -22), and all but Fe3O4 NP induce an increased migration of macrophages (Boyden chamber). Iron(III) oxide 51-56 C-C motif chemokine ligand 2 Homo sapiens 191-196 24885771-6 2014 In vitro macrophage exposure to representative NP (Fe2O3, Fe3O4, MnFe2O4 and CrOOH) induced the production of a pro-inflammatory secretome (increased production of CXCL-8, IL-1ss, TNF-alpha, CCL-2, -3, -4, and to a lesser extent IL-6, CCL-7 and -22), and all but Fe3O4 NP induce an increased migration of macrophages (Boyden chamber). crooh 77-82 C-C motif chemokine ligand 2 Homo sapiens 191-196 24689518-7 2014 CONCLUSIONS: These preliminary findings are consistent with the hypothesis that neuroinflammation as indexed by CSF MCP-1 is associated with alcohol-induced liver inflammation, as defined by peripheral concentrations of GGT and AST/GOT. Alcohols 141-148 C-C motif chemokine ligand 2 Homo sapiens 116-121 24782172-0 2014 Effects of mycophenolate mofetil on the expression of monocyte chemoattractant protein-1 and fibronectin in high glucose cultured human mesangial cells. Mycophenolic Acid 11-32 C-C motif chemokine ligand 2 Homo sapiens 54-88 29764065-4 2014 RESULTS: Suggestive relationships have been established between lipid plasma levels and total bilirubin and SNPs in CETP, MCP1, ABCC2, LEP and SLCO1B3 genes and between diarrhea and SNPs in IL6 gene. Bilirubin 94-103 C-C motif chemokine ligand 2 Homo sapiens 122-126 24493202-10 2014 MCP-1 was upregulated and blocked by CLI-095, but not by palmitate. ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 37-44 C-C motif chemokine ligand 2 Homo sapiens 0-5 24584901-0 2014 Inhibitory effects of resveratrol on foam cell formation are mediated through monocyte chemotactic protein-1 and lipid metabolism-related proteins. Resveratrol 22-33 C-C motif chemokine ligand 2 Homo sapiens 78-108 24584901-14 2014 However, the effects of resveratrol on SIRT1, PPARgamma and PPARalpha expression and lipid accumulation were reversed when the cells were pre-treated with compound C. Resveratrol downregulated the mRNA expression of MCP-1 in a dose-dependent manner and LPS upregulate its expression in a time-dependent manner. Resveratrol 24-35 C-C motif chemokine ligand 2 Homo sapiens 216-221 24584901-14 2014 However, the effects of resveratrol on SIRT1, PPARgamma and PPARalpha expression and lipid accumulation were reversed when the cells were pre-treated with compound C. Resveratrol downregulated the mRNA expression of MCP-1 in a dose-dependent manner and LPS upregulate its expression in a time-dependent manner. Resveratrol 167-178 C-C motif chemokine ligand 2 Homo sapiens 216-221 24584901-15 2014 MCP-1 expression induced by LPS was inhibited by resveratrol at both the transcriptional and translational level. Resveratrol 49-60 C-C motif chemokine ligand 2 Homo sapiens 0-5 24584901-16 2014 These data suggest that resveratrol inhibits foam cell formation by regulating the expression of MCP-1 and activating the AMPK-SIRT1-PPAR signaling pathway; thus, resveratrol may be a novel therapeutic agent for atherosclerosis. Resveratrol 24-35 C-C motif chemokine ligand 2 Homo sapiens 97-102 24584901-16 2014 These data suggest that resveratrol inhibits foam cell formation by regulating the expression of MCP-1 and activating the AMPK-SIRT1-PPAR signaling pathway; thus, resveratrol may be a novel therapeutic agent for atherosclerosis. Resveratrol 163-174 C-C motif chemokine ligand 2 Homo sapiens 97-102 24782172-0 2014 Effects of mycophenolate mofetil on the expression of monocyte chemoattractant protein-1 and fibronectin in high glucose cultured human mesangial cells. Glucose 113-120 C-C motif chemokine ligand 2 Homo sapiens 54-88 24782172-1 2014 The effects of high glucose on the expression of monocyte chemoattractant protein-1 (MCP-1) and the main component of the extracellular matrix, fibronectin (FN), were explored in human mesangial cells (HMCs), along with the intervention effects of mycophenolate mofetil (MMF) on these indicators. Glucose 20-27 C-C motif chemokine ligand 2 Homo sapiens 49-83 24782172-1 2014 The effects of high glucose on the expression of monocyte chemoattractant protein-1 (MCP-1) and the main component of the extracellular matrix, fibronectin (FN), were explored in human mesangial cells (HMCs), along with the intervention effects of mycophenolate mofetil (MMF) on these indicators. Glucose 20-27 C-C motif chemokine ligand 2 Homo sapiens 85-90 24782172-4 2014 MCP-1 mRNA and protein expressions and FN secretion significantly increased in HMCs of the high glucose group compared with the normal control group (P < 0.01), with the highest expression observed at 48 h. MMF could reduce the MCP-1 mRNA and protein and FN expression levels (P < 0.01), and the inhibition occurred in a dose- and time-dependent manner (P < 0.05). Glucose 96-103 C-C motif chemokine ligand 2 Homo sapiens 0-5 24782172-4 2014 MCP-1 mRNA and protein expressions and FN secretion significantly increased in HMCs of the high glucose group compared with the normal control group (P < 0.01), with the highest expression observed at 48 h. MMF could reduce the MCP-1 mRNA and protein and FN expression levels (P < 0.01), and the inhibition occurred in a dose- and time-dependent manner (P < 0.05). Glucose 96-103 C-C motif chemokine ligand 2 Homo sapiens 231-236 24736562-4 2014 While PolyI:C induced maximal cytokine and chemokine production from both PHCEC (IFNgamma, CCL2, CCL3, and (CCL4), IL6, CXCL10, CCL5, TNFalpha) and PHKF (CCL2, IL-6, CXCL10, CCL5), only PHKF cytokines were inhibited by GCs. Poly I-C 6-13 C-C motif chemokine ligand 2 Homo sapiens 154-158 24736562-4 2014 While PolyI:C induced maximal cytokine and chemokine production from both PHCEC (IFNgamma, CCL2, CCL3, and (CCL4), IL6, CXCL10, CCL5, TNFalpha) and PHKF (CCL2, IL-6, CXCL10, CCL5), only PHKF cytokines were inhibited by GCs. Poly I-C 6-13 C-C motif chemokine ligand 2 Homo sapiens 91-95 24548972-9 2014 Additionally, the proposed hypothesis is strengthened by the indirect experimental findings indicating that CNTs and fullerenes induce an excessive expression of specific cytokines and chemokines (i.e. IL-8 and MCP1). Fullerenes 117-127 C-C motif chemokine ligand 2 Homo sapiens 211-215 24550391-5 2014 NaHS markedly suppressed NF-kappaB p65 phosphorylation, nuclear translocation, DNA binding activity, and recruitment to the MCP-1 promoter in ox-LDL-treated macrophages. sodium bisulfide 0-4 C-C motif chemokine ligand 2 Homo sapiens 124-129 24550391-0 2014 Hydrogen sulfide suppresses oxidized low-density lipoprotein (ox-LDL)-stimulated monocyte chemoattractant protein 1 generation from macrophages via the nuclear factor kappaB (NF-kappaB) pathway. Hydrogen Sulfide 0-16 C-C motif chemokine ligand 2 Homo sapiens 81-115 24550391-1 2014 This study was designed to examine the role of hydrogen sulfide (H2S) in the generation of oxidized low-density lipoprotein (ox-LDL)-stimulated monocyte chemoattractant protein 1 (MCP-1) from macrophages and possible mechanisms. Hydrogen Sulfide 47-63 C-C motif chemokine ligand 2 Homo sapiens 144-178 24550391-8 2014 These results suggested that endogenous H2S inhibited ox-LDL-induced macrophage inflammation by suppressing NF-kappaB p65 phosphorylation, nuclear translocation, DNA binding activity, and recruitment to the MCP-1 promoter. Hydrogen Sulfide 40-43 C-C motif chemokine ligand 2 Homo sapiens 207-212 24550391-1 2014 This study was designed to examine the role of hydrogen sulfide (H2S) in the generation of oxidized low-density lipoprotein (ox-LDL)-stimulated monocyte chemoattractant protein 1 (MCP-1) from macrophages and possible mechanisms. Hydrogen Sulfide 47-63 C-C motif chemokine ligand 2 Homo sapiens 180-185 24550391-1 2014 This study was designed to examine the role of hydrogen sulfide (H2S) in the generation of oxidized low-density lipoprotein (ox-LDL)-stimulated monocyte chemoattractant protein 1 (MCP-1) from macrophages and possible mechanisms. Hydrogen Sulfide 65-68 C-C motif chemokine ligand 2 Homo sapiens 144-178 24662749-6 2014 RESULTS: The results showed that LPS significantly increased MCP-1 and TLR4 expression and MCP-1 secretion in 3T3-L1 adipocytes, and that the MCP-1 expression was blocked by a TLR4 inhibitor (CLI095). ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 192-198 C-C motif chemokine ligand 2 Homo sapiens 61-66 24550391-1 2014 This study was designed to examine the role of hydrogen sulfide (H2S) in the generation of oxidized low-density lipoprotein (ox-LDL)-stimulated monocyte chemoattractant protein 1 (MCP-1) from macrophages and possible mechanisms. Hydrogen Sulfide 65-68 C-C motif chemokine ligand 2 Homo sapiens 180-185 25245457-2 2014 We show here that low extracellular magnesium stimulates the secretion of interleukin 8 and monocyte chemoattractant protein-1 in dermal microvascular endothelial cells. Magnesium 36-45 C-C motif chemokine ligand 2 Homo sapiens 92-126 24338998-6 2014 Additionally, phloretin inhibited monocyte secretion of MCP-1, IL-6 and IL-8 responsible for pro-inflammatory activity of thrombin inducing endothelial CD40. Phloretin 14-23 C-C motif chemokine ligand 2 Homo sapiens 56-61 24344240-10 2014 And the IL-33-induced CCL2/CCR2 expression was abrogated by treatment with the NF-kappaB inhibitor BAY 11-7082 or ERK1/2 inhibitor U0126. 3-(4-methylphenylsulfonyl)-2-propenenitrile 99-110 C-C motif chemokine ligand 2 Homo sapiens 22-26 24344240-10 2014 And the IL-33-induced CCL2/CCR2 expression was abrogated by treatment with the NF-kappaB inhibitor BAY 11-7082 or ERK1/2 inhibitor U0126. U 0126 131-136 C-C motif chemokine ligand 2 Homo sapiens 22-26 24662749-0 2014 Effects of LPS and dietary free fatty acids on MCP-1 in 3T3-L1 adipocytes and macrophages in vitro. Fatty Acids, Nonesterified 27-43 C-C motif chemokine ligand 2 Homo sapiens 47-52 24684779-7 2014 RESULTS: Simvastatin significantly reduced plasma interleukin-6, leptin, resistin and monocyte chemoattractant protein-1 (p < 0.001 for all); pioglitazone reduced interleukin-6, tumoral necrose factor-alpha, resistin and matrix metalloproteinase-9 (p < 0.001 for all). Simvastatin 9-20 C-C motif chemokine ligand 2 Homo sapiens 86-120 24662749-6 2014 RESULTS: The results showed that LPS significantly increased MCP-1 and TLR4 expression and MCP-1 secretion in 3T3-L1 adipocytes, and that the MCP-1 expression was blocked by a TLR4 inhibitor (CLI095). ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 192-198 C-C motif chemokine ligand 2 Homo sapiens 91-96 24662749-6 2014 RESULTS: The results showed that LPS significantly increased MCP-1 and TLR4 expression and MCP-1 secretion in 3T3-L1 adipocytes, and that the MCP-1 expression was blocked by a TLR4 inhibitor (CLI095). ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 192-198 C-C motif chemokine ligand 2 Homo sapiens 91-96 24662749-8 2014 In macrophages, palmitic acid increased MCP-1 mRNA expression by 1.8-fold (P<0.05), but oleic acid and elaidic acid had no effects. Palmitic Acid 16-29 C-C motif chemokine ligand 2 Homo sapiens 40-45 24662749-10 2014 The different classes of FFA did not induce MCP-1 mRNA expression or protein secretion in the adipocytes, but the saturated FFA, palmitic acid, induced MCP-1 mRNA expression in macrophages, possibly because of the higher expression level of TLR4 in the macrophages than the adipocytes. Palmitic Acid 129-142 C-C motif chemokine ligand 2 Homo sapiens 152-157 24361424-4 2014 Monocyte chemotactic protein-1 (MCP-1) and interleukin-6 (IL-6) were identified as two cytokines present in MCM, at concentrations that have previously been shown to influence VSMC phenotype. vsmc 176-180 C-C motif chemokine ligand 2 Homo sapiens 0-30 24361424-4 2014 Monocyte chemotactic protein-1 (MCP-1) and interleukin-6 (IL-6) were identified as two cytokines present in MCM, at concentrations that have previously been shown to influence VSMC phenotype. vsmc 176-180 C-C motif chemokine ligand 2 Homo sapiens 32-37 24587317-9 2014 In primary hPdLCs, both 25(OH)D3 and 1,25(OH)2D3 inhibited the production of IL-8 and MCP-1 but have no significant effect on the IL-6 production. Calcifediol 24-32 C-C motif chemokine ligand 2 Homo sapiens 86-91 27122781-8 2014 The intracellular mechanism about the effects of vitamin A, C and 1alpha,25-(OH)2D3 on the expression of MCP-1 expression in human monocytes was assessed by western blot. Vitamin A 49-58 C-C motif chemokine ligand 2 Homo sapiens 105-110 27122781-8 2014 The intracellular mechanism about the effects of vitamin A, C and 1alpha,25-(OH)2D3 on the expression of MCP-1 expression in human monocytes was assessed by western blot. 1alpha, 66-73 C-C motif chemokine ligand 2 Homo sapiens 105-110 27122781-8 2014 The intracellular mechanism about the effects of vitamin A, C and 1alpha,25-(OH)2D3 on the expression of MCP-1 expression in human monocytes was assessed by western blot. 25-(oh)2d3 73-83 C-C motif chemokine ligand 2 Homo sapiens 105-110 27122781-9 2014 RESULTS: We found that Lipopolysaccharides (LPS)-induced MCP-1 production was suppressed by 1alpha,25-(OH)2D3 in THP-1 cells and THP-1-induced macrophage. 1alpha, 92-99 C-C motif chemokine ligand 2 Homo sapiens 57-62 27122781-9 2014 RESULTS: We found that Lipopolysaccharides (LPS)-induced MCP-1 production was suppressed by 1alpha,25-(OH)2D3 in THP-1 cells and THP-1-induced macrophage. 25-(oh)2d3 99-109 C-C motif chemokine ligand 2 Homo sapiens 57-62 27122781-10 2014 Only high concentration of vitamin A and C could reduce LPS-induced MCP-1 production in THP-1-induced macrophage, but not in THP-1 cells. Vitamin A 27-36 C-C motif chemokine ligand 2 Homo sapiens 68-73 27122781-12 2014 A selective p38 pathway inhibitor SB203580 could also suppress LPS-induced MCP-1 production. SB 203580 34-42 C-C motif chemokine ligand 2 Homo sapiens 75-80 27122781-13 2014 However, vitamin D receptor blocking antibody could reverse the suppressive effect of 1alpha,25-(OH)2D3 on MCP-1 expression. 1alpha 86-92 C-C motif chemokine ligand 2 Homo sapiens 107-112 27122781-13 2014 However, vitamin D receptor blocking antibody could reverse the suppressive effect of 1alpha,25-(OH)2D3 on MCP-1 expression. 25-(oh)2d3 93-103 C-C motif chemokine ligand 2 Homo sapiens 107-112 27122781-14 2014 CONCLUSIONS: These data demonstrate that 1alpha,25-(OH)2D3 is effective in down-regulating LPS-induced MCP-1. 25-(oh)2d3 48-58 C-C motif chemokine ligand 2 Homo sapiens 103-108 24037783-4 2014 Treatment of cultured spinal astrocytes with isoproterenol (a beta-adrenergic receptor agonist; 1 microM) reduced both TNF-alpha-induced JNK1 phosphorylation, as observed by Western blotting, and the subsequent increase of both CCL2 mRNA expression and CCL2 production, which were measured by real time-PCR and ELISA, respectively. Isoproterenol 45-58 C-C motif chemokine ligand 2 Homo sapiens 228-232 24037783-4 2014 Treatment of cultured spinal astrocytes with isoproterenol (a beta-adrenergic receptor agonist; 1 microM) reduced both TNF-alpha-induced JNK1 phosphorylation, as observed by Western blotting, and the subsequent increase of both CCL2 mRNA expression and CCL2 production, which were measured by real time-PCR and ELISA, respectively. Isoproterenol 45-58 C-C motif chemokine ligand 2 Homo sapiens 253-257 24037783-8 2014 Moreover, treatment with isoproterenol markedly suppressed the TNF-alpha-induced increase of CCL2 mRNA expression and CCL2 production through a beta-adrenergic receptor-PKA pathway mediated by GSK-3beta regulation. Isoproterenol 25-38 C-C motif chemokine ligand 2 Homo sapiens 93-97 24037783-8 2014 Moreover, treatment with isoproterenol markedly suppressed the TNF-alpha-induced increase of CCL2 mRNA expression and CCL2 production through a beta-adrenergic receptor-PKA pathway mediated by GSK-3beta regulation. Isoproterenol 25-38 C-C motif chemokine ligand 2 Homo sapiens 118-122 27122781-0 2014 Effect of Vitamin D3 on Monocyte Chemoattractant Protein 1 Production in Monocytes and Macrophages. Cholecalciferol 10-20 C-C motif chemokine ligand 2 Homo sapiens 24-58 23815460-0 2014 Involvement of SDF-1 and monocyte chemoattractant protein-1 in hydrogen peroxide-induced extracellular matrix degradation in human dental pulp cells. Hydrogen Peroxide 63-80 C-C motif chemokine ligand 2 Homo sapiens 25-59 23815460-1 2014 AIM: To determine whether chemokines such as SDF-1 and monocyte chemoattractant protein-1 (MCP-1) are responsible for hydrogen peroxide (H2 O2 )-induced extracellular matrix (ECM) degradation and to identify the underlying mechanism in human dental pulp cells (HDPCs). Hydrogen Peroxide 118-135 C-C motif chemokine ligand 2 Homo sapiens 55-89 23815460-1 2014 AIM: To determine whether chemokines such as SDF-1 and monocyte chemoattractant protein-1 (MCP-1) are responsible for hydrogen peroxide (H2 O2 )-induced extracellular matrix (ECM) degradation and to identify the underlying mechanism in human dental pulp cells (HDPCs). Hydrogen Peroxide 118-135 C-C motif chemokine ligand 2 Homo sapiens 91-96 23815460-1 2014 AIM: To determine whether chemokines such as SDF-1 and monocyte chemoattractant protein-1 (MCP-1) are responsible for hydrogen peroxide (H2 O2 )-induced extracellular matrix (ECM) degradation and to identify the underlying mechanism in human dental pulp cells (HDPCs). Hydrogen Peroxide 137-142 C-C motif chemokine ligand 2 Homo sapiens 55-89 23815460-1 2014 AIM: To determine whether chemokines such as SDF-1 and monocyte chemoattractant protein-1 (MCP-1) are responsible for hydrogen peroxide (H2 O2 )-induced extracellular matrix (ECM) degradation and to identify the underlying mechanism in human dental pulp cells (HDPCs). Hydrogen Peroxide 137-142 C-C motif chemokine ligand 2 Homo sapiens 91-96 23815460-6 2014 RESULTS: Hydrogen peroxide provoked the activation of MCP-1 and SDF-1 mRNA and their respective receptors, CXCR4 and CXCR2. Hydrogen Peroxide 9-26 C-C motif chemokine ligand 2 Homo sapiens 54-59 23815460-8 2014 Hydrogen peroxide-induced ECM degradation and MMP upregulation were blocked by neutralizing antibodies and siRNAs directed against SDF-1 and MCP-1. Hydrogen Peroxide 0-17 C-C motif chemokine ligand 2 Homo sapiens 141-146 23815460-9 2014 Inhibition of SDF-1 and MCP-1 blocked the H2 O2 -induced activation of Akt, p38, ERK and NF-kB. Hydrogen Peroxide 42-47 C-C motif chemokine ligand 2 Homo sapiens 24-29 23815460-10 2014 CONCLUSION: Inhibition of SDF and MCP-1 is a potent component of reducing release reactive oxygen species-induced ECM degradation in HDPCs and may play an important role in pulpal and periapical inflammation. Reactive Oxygen Species 82-105 C-C motif chemokine ligand 2 Homo sapiens 34-39 24587317-9 2014 In primary hPdLCs, both 25(OH)D3 and 1,25(OH)2D3 inhibited the production of IL-8 and MCP-1 but have no significant effect on the IL-6 production. Calcitriol 37-48 C-C motif chemokine ligand 2 Homo sapiens 86-91 24600221-6 2014 Consequently, the blood glucose concentration in the MCP-1 group was significantly lower than that in the control group at week 2 post-surgery. Glucose 24-31 C-C motif chemokine ligand 2 Homo sapiens 53-58 24586431-8 2014 Activation of PAR-4 by a selective agonist was found to elicit the pro-inflammatory and pro-fibrotic phenotypes in PTEC while blockade of the receptor by specific antagonist attenuated high glucose-induced IL-6, CCL-2, CTGF and collagen IV expression. Glucose 190-197 C-C motif chemokine ligand 2 Homo sapiens 212-217 24486487-5 2014 In lipopolysaccharide (LPS)-inflamed RAW264.7 macrophages, dh404 dramatically suppressed the expression of pro-inflammatory cytokines including inducible nitric oxide synthase (iNOS), monocyte chemotactic protein-1 (MCP-1), and macrophage inflammatory protein-1 beta (MIP-1beta), while minimally regulating the expression of interleulin-6 (IL-6), IL-1beta, and tumor necrosis factor alpha (TNFalpha). dh404 59-64 C-C motif chemokine ligand 2 Homo sapiens 184-214 24486487-5 2014 In lipopolysaccharide (LPS)-inflamed RAW264.7 macrophages, dh404 dramatically suppressed the expression of pro-inflammatory cytokines including inducible nitric oxide synthase (iNOS), monocyte chemotactic protein-1 (MCP-1), and macrophage inflammatory protein-1 beta (MIP-1beta), while minimally regulating the expression of interleulin-6 (IL-6), IL-1beta, and tumor necrosis factor alpha (TNFalpha). dh404 59-64 C-C motif chemokine ligand 2 Homo sapiens 216-221 24600221-8 2014 The rapid decrease of blood creatinine, urine creatinine, and blood urea nitrogen suggested that the recovery of renal functions compromised by hyperglycemia could also be attributed to MCP-1. Urea 68-72 C-C motif chemokine ligand 2 Homo sapiens 186-191 24600221-8 2014 The rapid decrease of blood creatinine, urine creatinine, and blood urea nitrogen suggested that the recovery of renal functions compromised by hyperglycemia could also be attributed to MCP-1. Nitrogen 73-81 C-C motif chemokine ligand 2 Homo sapiens 186-191 24287278-10 2014 By contrast, FK866 boosted TNFalpha-induced expression of MCP-1 and RANTES mRNA and endogenous NAMPT targeting by siRNA also had a proinflammatory effect. N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide 13-18 C-C motif chemokine ligand 2 Homo sapiens 58-63 24405838-9 2014 Changes in TNF-alpha, IL-6 and MCP-1 levels after spironolactone treatment were significantly correlated with changes in HOMA-IR (r=0.61, r=0.55 and r=0.65, respectively; p=0.01, p=0.03 and p=0.01, respectively). Spironolactone 50-64 C-C motif chemokine ligand 2 Homo sapiens 31-36 24182989-8 2014 Pretreatment with TQ also inhibited the LPS-induced proinflammatory response in LX2 cells as demonstrated by reduced mRNA expression of IL-6 and MCP-1. thymoquinone 18-20 C-C motif chemokine ligand 2 Homo sapiens 145-150 23981542-10 2014 Resveratrol was superior to dexamethasone in reducing CCL-2, IL-6 and IL-8 in LTA-exposed HASMCs of patients with COPD. Resveratrol 0-11 C-C motif chemokine ligand 2 Homo sapiens 54-59 24405838-7 2014 TNF-alpha, IL-6 and MCP-1 decreased with spironolactone (p=0.002, p=0.02 and p=0.02 vs. baseline, respectively), but not with furosemide. Spironolactone 41-55 C-C motif chemokine ligand 2 Homo sapiens 20-25 24390544-5 2014 Treatment of macrophages with n-butyrate led to the down-regulation of lipopolysaccharide-induced proinflammatory mediators, including nitric oxide, IL-6, and IL-12, but did not affect levels of TNF-alpha or MCP-1. Butyrates 30-40 C-C motif chemokine ligand 2 Homo sapiens 208-213 24018781-5 2014 Olmesartan/amlodipine significantly decreased Hs-CRP, MCP-1, and MIP-1beta. olmesartan 0-10 C-C motif chemokine ligand 2 Homo sapiens 54-59 23025717-8 2014 Cortisol upregulated collagen1 and MCP-1 mRNAs via the glucocorticoid receptor (GRalpha), in both VSMC phenotypes, whereas fludrocortisone stimulated the collagen1 expression only in lipid-storing VSMCs. Hydrocortisone 0-8 C-C motif chemokine ligand 2 Homo sapiens 35-40 23025717-8 2014 Cortisol upregulated collagen1 and MCP-1 mRNAs via the glucocorticoid receptor (GRalpha), in both VSMC phenotypes, whereas fludrocortisone stimulated the collagen1 expression only in lipid-storing VSMCs. vsmc 98-102 C-C motif chemokine ligand 2 Homo sapiens 35-40 24018781-5 2014 Olmesartan/amlodipine significantly decreased Hs-CRP, MCP-1, and MIP-1beta. Amlodipine 11-21 C-C motif chemokine ligand 2 Homo sapiens 54-59 24337644-6 2014 15d-PGJ(2) and CV3988 inhibited the LPS-induced mRNA expression and protein production of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecule-1 (ICAM-1) in ARPE19 cells. CV 3988 15-21 C-C motif chemokine ligand 2 Homo sapiens 148-153 24337644-6 2014 15d-PGJ(2) and CV3988 inhibited the LPS-induced mRNA expression and protein production of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecule-1 (ICAM-1) in ARPE19 cells. 15d-pgj 0-7 C-C motif chemokine ligand 2 Homo sapiens 112-146 24316968-7 2014 Carnosol not only inhibited TNF-alpha-induced protein expression of intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1 and E-selectin in HUVECs, but also suppressed interleukin (IL)-8 and monocyte chemoattractant protein (MCP)-1 expression. carnosol 0-8 C-C motif chemokine ligand 2 Homo sapiens 220-260 24337644-6 2014 15d-PGJ(2) and CV3988 inhibited the LPS-induced mRNA expression and protein production of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecule-1 (ICAM-1) in ARPE19 cells. 15d-pgj 0-7 C-C motif chemokine ligand 2 Homo sapiens 148-153 24337644-6 2014 15d-PGJ(2) and CV3988 inhibited the LPS-induced mRNA expression and protein production of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion molecule-1 (ICAM-1) in ARPE19 cells. CV 3988 15-21 C-C motif chemokine ligand 2 Homo sapiens 112-146 23996571-4 2014 MCP-1 induction preceded peak induction of calcium signaling activator calmodulin 1 (CALM1) and transcription factors JUN and FOS, which were at 3 days. Calcium 43-50 C-C motif chemokine ligand 2 Homo sapiens 0-5 24328351-1 2014 Insertion of dichlorocarbene (:CCl2), generated by decomposition of the Seyferth reagent PhHgCCl2Br, into the Si-H bond of a tertiary silane to form a Si-CCl2H group is an efficient homogeneous, molecular transformation. dichlorocarbene 13-28 C-C motif chemokine ligand 2 Homo sapiens 31-35 24315932-8 2014 We found that ritonavir administration caused intestinal damage and its co-administration with naproxen or ASA exacerbated the severity of injury and intestinal inflammation, as assessed by measuring haematocrit, MPO, mucosal levels of PGE2 and mRNA levels of iNOS, MCP-1 and VLA-1. Ritonavir 14-23 C-C motif chemokine ligand 2 Homo sapiens 266-271 24315932-8 2014 We found that ritonavir administration caused intestinal damage and its co-administration with naproxen or ASA exacerbated the severity of injury and intestinal inflammation, as assessed by measuring haematocrit, MPO, mucosal levels of PGE2 and mRNA levels of iNOS, MCP-1 and VLA-1. Naproxen 95-103 C-C motif chemokine ligand 2 Homo sapiens 266-271 24315932-8 2014 We found that ritonavir administration caused intestinal damage and its co-administration with naproxen or ASA exacerbated the severity of injury and intestinal inflammation, as assessed by measuring haematocrit, MPO, mucosal levels of PGE2 and mRNA levels of iNOS, MCP-1 and VLA-1. Aspirin 107-110 C-C motif chemokine ligand 2 Homo sapiens 266-271 24460726-0 2014 Reduced levels of CCL2 and CXCL10 in systemic lupus erythematosus patients under treatment with prednisone, mycophenolate mofetil, or hydroxychloroquine, except in a high STAT1 subset. Prednisone 96-106 C-C motif chemokine ligand 2 Homo sapiens 18-22 24460726-0 2014 Reduced levels of CCL2 and CXCL10 in systemic lupus erythematosus patients under treatment with prednisone, mycophenolate mofetil, or hydroxychloroquine, except in a high STAT1 subset. Mycophenolic Acid 108-129 C-C motif chemokine ligand 2 Homo sapiens 18-22 24460726-0 2014 Reduced levels of CCL2 and CXCL10 in systemic lupus erythematosus patients under treatment with prednisone, mycophenolate mofetil, or hydroxychloroquine, except in a high STAT1 subset. Hydroxychloroquine 134-152 C-C motif chemokine ligand 2 Homo sapiens 18-22 24731463-6 2014 The proliferation of FLS after an addition of culture supernatant of NKp44+NK cells was detected by methyl thiazolyl tetrazolium (MTT) at 24, 48 and 72 h. Monocyte chemotactic protein (MCP)-1 production of RA FLS after an addition of rhIL-22 was detected by ELISA. methyl thiazolyl tetrazolium 100-128 C-C motif chemokine ligand 2 Homo sapiens 155-191 24731463-6 2014 The proliferation of FLS after an addition of culture supernatant of NKp44+NK cells was detected by methyl thiazolyl tetrazolium (MTT) at 24, 48 and 72 h. Monocyte chemotactic protein (MCP)-1 production of RA FLS after an addition of rhIL-22 was detected by ELISA. monooxyethylene trimethylolpropane tristearate 130-133 C-C motif chemokine ligand 2 Homo sapiens 155-191 24328351-1 2014 Insertion of dichlorocarbene (:CCl2), generated by decomposition of the Seyferth reagent PhHgCCl2Br, into the Si-H bond of a tertiary silane to form a Si-CCl2H group is an efficient homogeneous, molecular transformation. seyferth 72-80 C-C motif chemokine ligand 2 Homo sapiens 31-35 24328351-1 2014 Insertion of dichlorocarbene (:CCl2), generated by decomposition of the Seyferth reagent PhHgCCl2Br, into the Si-H bond of a tertiary silane to form a Si-CCl2H group is an efficient homogeneous, molecular transformation. phhgccl2br 89-99 C-C motif chemokine ligand 2 Homo sapiens 31-35 24328351-1 2014 Insertion of dichlorocarbene (:CCl2), generated by decomposition of the Seyferth reagent PhHgCCl2Br, into the Si-H bond of a tertiary silane to form a Si-CCl2H group is an efficient homogeneous, molecular transformation. Silicon 110-112 C-C motif chemokine ligand 2 Homo sapiens 31-35 24328351-1 2014 Insertion of dichlorocarbene (:CCl2), generated by decomposition of the Seyferth reagent PhHgCCl2Br, into the Si-H bond of a tertiary silane to form a Si-CCl2H group is an efficient homogeneous, molecular transformation. Silanes 134-140 C-C motif chemokine ligand 2 Homo sapiens 31-35 24328351-1 2014 Insertion of dichlorocarbene (:CCl2), generated by decomposition of the Seyferth reagent PhHgCCl2Br, into the Si-H bond of a tertiary silane to form a Si-CCl2H group is an efficient homogeneous, molecular transformation. Silicon 151-153 C-C motif chemokine ligand 2 Homo sapiens 31-35 24328351-1 2014 Insertion of dichlorocarbene (:CCl2), generated by decomposition of the Seyferth reagent PhHgCCl2Br, into the Si-H bond of a tertiary silane to form a Si-CCl2H group is an efficient homogeneous, molecular transformation. ccl2h 154-159 C-C motif chemokine ligand 2 Homo sapiens 31-35 24232001-5 2014 Pre- and coadministration of paeoniflorin significantly reduced the severity of colitis and resulted in downregulation of several inflammatory parameters in the colon, including the activity of myeloperoxidase (MPO), the levels of TNF-alpha and IL-6, and the mRNA expression of proinflammatory mediators (MCP-1, Cox2, IFN-gamma, TNF-alpha, IL-6, and IL-17). peoniflorin 29-41 C-C motif chemokine ligand 2 Homo sapiens 305-310 24269954-8 2014 Our results showed that pre-treatment with EGCG could significantly reduce the production of TNF-alpha, Rantes, MCP-1, ICAM-1, NO, VEGF, and MMP-2 in LPS-stimulated L02 hepatocytes in a dose-dependent manner. epigallocatechin gallate 43-47 C-C motif chemokine ligand 2 Homo sapiens 112-117 25033895-6 2014 Furthermore, MCP-1-induced secretion of MMP-9 was inhibited by U0126 (inhibitor of the ERK 1/2 pathway) and SB203580 (inhibitor of the p38 MAPK pathway), but not SP600125 (inhibitor of the JNK1/2 pathway). U 0126 63-68 C-C motif chemokine ligand 2 Homo sapiens 13-18 23817506-11 2014 Simvastatin resulted in a significant decrease in plasma MCP-1 on day 3 and reduced exhaled breath condensate acidification. Simvastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 57-62 25162011-3 2014 We assessed the ability of EA and RA to modulate IL-1beta, IL-6, IL-8, IL-10, MCP-1, and TNF-alpha gene expression in HaCaT cells after UVB irradiation. Ellagic Acid 27-29 C-C motif chemokine ligand 2 Homo sapiens 78-83 23917077-6 2014 Expression microarray analysis followed by reverse transcription-PCR revealed that adipocytes respond directly to asbestos exposure with an increased production of proinflammatory adipocytokines [e.g. monocyte chemoattractant protein-1 (MCP-1)], whereas the production of anti-inflammatory adipocytokines (e.g. adiponectin) is suppressed. Asbestos 114-122 C-C motif chemokine ligand 2 Homo sapiens 201-235 23917077-6 2014 Expression microarray analysis followed by reverse transcription-PCR revealed that adipocytes respond directly to asbestos exposure with an increased production of proinflammatory adipocytokines [e.g. monocyte chemoattractant protein-1 (MCP-1)], whereas the production of anti-inflammatory adipocytokines (e.g. adiponectin) is suppressed. Asbestos 114-122 C-C motif chemokine ligand 2 Homo sapiens 237-242 24852948-0 2014 Green tea polyphenol epigallocatechin-3-gallate inhibits TNF-alpha-induced production of monocyte chemoattractant protein-1 in human umbilical vein endothelial cells. polyphenol epigallocatechin-3-gallate 10-47 C-C motif chemokine ligand 2 Homo sapiens 89-123 24852948-2 2014 This study was conducted to test the hypothesis that EGCG was able to inhibit tumor necrosis factor-alpha (TNF-alpha)-induced production of monocyte chemoattractant protein-1 (MCP-1) in human umbilical vein endothelial cells (HUVECs) and investigated the underlying molecular mechanisms. epigallocatechin gallate 53-57 C-C motif chemokine ligand 2 Homo sapiens 140-174 24852948-2 2014 This study was conducted to test the hypothesis that EGCG was able to inhibit tumor necrosis factor-alpha (TNF-alpha)-induced production of monocyte chemoattractant protein-1 (MCP-1) in human umbilical vein endothelial cells (HUVECs) and investigated the underlying molecular mechanisms. epigallocatechin gallate 53-57 C-C motif chemokine ligand 2 Homo sapiens 176-181 24852948-3 2014 METHODS: The inhibitory effect of EGCG on TNF-alpha-induced expression of MCP-1 was measured using ELISA and RT-qPCR. epigallocatechin gallate 34-38 C-C motif chemokine ligand 2 Homo sapiens 74-79 24852948-6 2014 RESULTS: EGCG significantly suppressed the TNF-alpha-induced protein and mRNA expression of MCP-1. epigallocatechin gallate 9-13 C-C motif chemokine ligand 2 Homo sapiens 92-97 24852948-8 2014 In addition, the 67-kD laminin receptor (67LR) was involved in EGCG-mediated suppression of MCP-1 generation. epigallocatechin gallate 63-67 C-C motif chemokine ligand 2 Homo sapiens 92-97 24852948-10 2014 CONCLUSION: EGCG suppresses TNF-alpha-induced MCP-1 expression in HUVECs. epigallocatechin gallate 12-16 C-C motif chemokine ligand 2 Homo sapiens 46-51 25323428-1 2014 BACKGROUND: The aim of this study was to investigate the association between the dialysate MCP-1 (dMCP-1) and systemic inflammatory and nutritional markers in peritoneal dialysis (PD) patients. Dimyristoylphosphatidylcholine 98-102 C-C motif chemokine ligand 2 Homo sapiens 91-96 25162011-7 2014 RA produced a significant reduction in UVB-induced expression of IL-6, IL-8, MCP-1, and TNF-alpha when applied at the same time as irradiation. rosmarinic acid 0-2 C-C motif chemokine ligand 2 Homo sapiens 77-82 25033895-6 2014 Furthermore, MCP-1-induced secretion of MMP-9 was inhibited by U0126 (inhibitor of the ERK 1/2 pathway) and SB203580 (inhibitor of the p38 MAPK pathway), but not SP600125 (inhibitor of the JNK1/2 pathway). SB 203580 108-116 C-C motif chemokine ligand 2 Homo sapiens 13-18 24720535-8 2014 LLT with S and S+E reduced MCP-1 levels (P < 0 01 by anova) and IFNgamma levels (P < 0 01) in DM-CKD patients but not in DM-only patients. Sulfur 9-10 C-C motif chemokine ligand 2 Homo sapiens 27-32 24525800-3 2014 In this study, delayed administration of Q-VD-OPh, 12 and 36 h after HI, decreased HI-induced caspase-3 activity (DEVD cleavage) by 23% and diminished the levels of the proinflammatory chemokines CCL2 (MCP-1) and CCL3 (MIP-1alpha) by 29.3 and 29.1%, respectively, but not the levels of the anti-inflammatory cytokines IL-4 and IL-10. hi 83-85 C-C motif chemokine ligand 2 Homo sapiens 196-200 24525800-3 2014 In this study, delayed administration of Q-VD-OPh, 12 and 36 h after HI, decreased HI-induced caspase-3 activity (DEVD cleavage) by 23% and diminished the levels of the proinflammatory chemokines CCL2 (MCP-1) and CCL3 (MIP-1alpha) by 29.3 and 29.1%, respectively, but not the levels of the anti-inflammatory cytokines IL-4 and IL-10. hi 83-85 C-C motif chemokine ligand 2 Homo sapiens 202-207 24720535-8 2014 LLT with S and S+E reduced MCP-1 levels (P < 0 01 by anova) and IFNgamma levels (P < 0 01) in DM-CKD patients but not in DM-only patients. Sulfur 15-16 C-C motif chemokine ligand 2 Homo sapiens 27-32 23948942-8 2014 Astroglial activation and CCL2 release was induced by ATP released by damaged neurons through interaction with P2X7 receptors present on astrocyte surface. Adenosine Triphosphate 54-57 C-C motif chemokine ligand 2 Homo sapiens 26-30 24135266-0 2014 Simvastatin reduces CCL2 expression in monocyte-derived cells by induction of a repressive CCL2 chromatin state. Simvastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 20-24 24135266-0 2014 Simvastatin reduces CCL2 expression in monocyte-derived cells by induction of a repressive CCL2 chromatin state. Simvastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 91-95 24135266-5 2014 In this study, we found that simvastatin reduces secretion and gene expression of CCL2 in monocyte-derived immature dendritic cells and in type 1 macrophages, which is accompanied by increased levels of the 3meK27H3 and 3meK9H3 repressive histone marks and decreased levels of the permissive histone marks AcH3 and 3meK4H3 in CCL2 promoter chromatin. Simvastatin 29-40 C-C motif chemokine ligand 2 Homo sapiens 82-86 24135266-5 2014 In this study, we found that simvastatin reduces secretion and gene expression of CCL2 in monocyte-derived immature dendritic cells and in type 1 macrophages, which is accompanied by increased levels of the 3meK27H3 and 3meK9H3 repressive histone marks and decreased levels of the permissive histone marks AcH3 and 3meK4H3 in CCL2 promoter chromatin. Simvastatin 29-40 C-C motif chemokine ligand 2 Homo sapiens 326-330 24895793-3 2014 METHODOLOGY: Concentrations of MCP-1 in serum were determined in 165 patients with chronic hepatitis C (CHC) treated with interferon and ribavirin by enzyme linked immunosorbent assay before and 48 weeks after cessation of therapy. Ribavirin 137-146 C-C motif chemokine ligand 2 Homo sapiens 31-36 23948942-0 2014 Bindarit, inhibitor of CCL2 synthesis, protects neurons against amyloid-beta-induced toxicity. bindarit 0-8 C-C motif chemokine ligand 2 Homo sapiens 23-27 23948942-6 2014 In the present study, we demonstrated the protective effect of bindarit (which inhibits CCL2 synthesis) against both Abeta25-35 and Abeta1-42-induced toxicity in primary mixed neural cultures. bindarit 63-71 C-C motif chemokine ligand 2 Homo sapiens 88-92 23948942-7 2014 Bindarit (30-500 muM) reversed cell death induced by Abeta in a dose-dependent manner and reduced the transcription and release of CCL2 by astrocytes after Abeta treatment, as revealed by qRT-PCR, ELISA, and immunofluorescence staining. bindarit 0-8 C-C motif chemokine ligand 2 Homo sapiens 131-135 24134561-0 2014 Mizoribine selectively attenuates monocyte chemoattractant protein-1 production in cultured human glomerular mesangial cell: a possible benefit of its use in the treatment of lupus nephritis. mizoribine 0-10 C-C motif chemokine ligand 2 Homo sapiens 34-68 24555677-7 2014 Exposure of THP-1 cells to both sizes of ZnO stimulated and increased release of proinflammatory cytokines interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, and IL-6, as well as chemokine IL-8, and upregulated the expression of monocyte chemoattractant protein-1 and cyclooxygenase-2 genes. Zinc Oxide 41-44 C-C motif chemokine ligand 2 Homo sapiens 237-271 25464609-6 2014 Dynamics of cytokine concentrations in supernatants of mononuclear leukocytes obtained after incubation of the cells with atorvastatin in vitro confirmed the assumption of direct inhibitory effect of this drug on spontaneous production of some proinflammatory cytokines (IL-6 and monocyte chemotactic protein-1). Atorvastatin 122-134 C-C motif chemokine ligand 2 Homo sapiens 280-310 25276053-2 2014 The extracellular nucleotide signalling molecules UTP and ATP acting via the P2Y2 receptor are known to induce CCL2 secretion in macrophages. Uridine Triphosphate 50-53 C-C motif chemokine ligand 2 Homo sapiens 111-115 25276053-2 2014 The extracellular nucleotide signalling molecules UTP and ATP acting via the P2Y2 receptor are known to induce CCL2 secretion in macrophages. Adenosine Triphosphate 58-61 C-C motif chemokine ligand 2 Homo sapiens 111-115 25276053-3 2014 We confirmed this in the human THP-1 monocytic cell line showing that UTP is as efficient as LPS at inducing CCL2 at early time points (2-6 hours). Uridine Triphosphate 70-73 C-C motif chemokine ligand 2 Homo sapiens 109-113 25276053-10 2014 Finally, we investigated CCL2 secretion in response to LPS or UTP in human macrophages expressing 312Arg-P2Y2 or 312Ser-P2Y2 where only the latter exhibited significant UTP-induced CCL2 secretion (n = 5 donors per group). Uridine Triphosphate 62-65 C-C motif chemokine ligand 2 Homo sapiens 25-29 25276053-10 2014 Finally, we investigated CCL2 secretion in response to LPS or UTP in human macrophages expressing 312Arg-P2Y2 or 312Ser-P2Y2 where only the latter exhibited significant UTP-induced CCL2 secretion (n = 5 donors per group). Uridine Triphosphate 169-172 C-C motif chemokine ligand 2 Homo sapiens 25-29 25276053-10 2014 Finally, we investigated CCL2 secretion in response to LPS or UTP in human macrophages expressing 312Arg-P2Y2 or 312Ser-P2Y2 where only the latter exhibited significant UTP-induced CCL2 secretion (n = 5 donors per group). Uridine Triphosphate 169-172 C-C motif chemokine ligand 2 Homo sapiens 181-185 24134561-7 2014 CONCLUSION: Mizoribine itself selectively attenuated the expression of MCP-1 both mRNA and protein levels in MCs treated with poly IC; that is, a possible model of "pseudoviral" infection, which may be involved in the pathogenesis of lupus nephritis. mizoribine 12-22 C-C motif chemokine ligand 2 Homo sapiens 71-76 25342084-3 2014 Vitreous fluid levels of VEGF, sVEGFR-2, sICAM-1, MCP-1 and PTX3 were significantly higher in the patients with DME than in those with MH. dme 112-115 C-C motif chemokine ligand 2 Homo sapiens 50-55 24225134-6 2014 Furthermore, TTM dose-dependently inhibited tumor necrosis factor alpha (TNFalpha)-induced activation of NF-kappaB and AP-1, as well as mRNA and protein expression of VCAM-1, ICAM-1, and MCP-1, which was abolished by preincubating the cells with 5 microM TTM and 15 microM cupric sulfate. tetrathiomolybdate 13-16 C-C motif chemokine ligand 2 Homo sapiens 187-192 24211271-8 2014 Additionally, cisplatin showed a marked pro-inflammatory response as evidenced by significant increase in tissue levels of IL-1beta, TNF-alpha, NF-kB, iNOS, ICAM-1 and MCP-1. Cisplatin 14-23 C-C motif chemokine ligand 2 Homo sapiens 168-173 24269812-0 2013 27-Hydroxycholesterol induces recruitment of monocytic cells by enhancing CCL2 production. 27-hydroxycholesterol 0-21 C-C motif chemokine ligand 2 Homo sapiens 74-78 24225134-4 2014 Incubating HAECs with cupric sulfate dose- and time-dependently increased mRNA and protein expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and monocyte chemotactic protein-1 (MCP-1). Copper Sulfate 22-36 C-C motif chemokine ligand 2 Homo sapiens 197-227 24225134-4 2014 Incubating HAECs with cupric sulfate dose- and time-dependently increased mRNA and protein expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and monocyte chemotactic protein-1 (MCP-1). Copper Sulfate 22-36 C-C motif chemokine ligand 2 Homo sapiens 229-234 24343720-6 2013 Candesartan reversed LPS-induced upregulation of TLR4 expression, inhibited NF-kappaB activation, and reduced MCP-1 and RANTES release. candesartan 0-11 C-C motif chemokine ligand 2 Homo sapiens 110-115 24134915-2 2013 Flavone effects were assessed on soluble pro-inflammatory mediator (IL-8, IL-6, macrophage chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2)-derived PGE2) production and on nuclear factor (NF)-kappaB activation in 3d-confluent and 21d-differentiated Caco-2 cells stimulated with interleukin (IL)-1beta. flavone 0-7 C-C motif chemokine ligand 2 Homo sapiens 80-116 24134915-2 2013 Flavone effects were assessed on soluble pro-inflammatory mediator (IL-8, IL-6, macrophage chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2)-derived PGE2) production and on nuclear factor (NF)-kappaB activation in 3d-confluent and 21d-differentiated Caco-2 cells stimulated with interleukin (IL)-1beta. flavone 0-7 C-C motif chemokine ligand 2 Homo sapiens 118-123 24269812-9 2013 Expression of CCL2 induced by 27-hydroxycholesterol was blocked when Akt inhibitor IV was added and when Akt1 was knocked down. 27-hydroxycholesterol 30-51 C-C motif chemokine ligand 2 Homo sapiens 14-18 23880643-9 2013 Fifteen cytokines/chemokines including Type 2 cytokines IL-13, MCP-1, and CD40 ligand were detected in ambient O2 ASC medium. Oxygen 111-113 C-C motif chemokine ligand 2 Homo sapiens 63-68 23880643-9 2013 Fifteen cytokines/chemokines including Type 2 cytokines IL-13, MCP-1, and CD40 ligand were detected in ambient O2 ASC medium. asc medium 114-124 C-C motif chemokine ligand 2 Homo sapiens 63-68 23564379-0 2013 CCL2/CCR2 augments the production of transforming growth factor-beta1, type 1 collagen and CCL2 by human CD45-/collagen 1-positive cells under high glucose concentrations. Glucose 148-155 C-C motif chemokine ligand 2 Homo sapiens 91-95 23564379-0 2013 CCL2/CCR2 augments the production of transforming growth factor-beta1, type 1 collagen and CCL2 by human CD45-/collagen 1-positive cells under high glucose concentrations. Glucose 148-155 C-C motif chemokine ligand 2 Homo sapiens 0-4 23999007-12 2013 TWEAK activated NFkappaB and increased MCP-1 mRNA and protein, an effect prevented by the NFkappaB inhibitor parthenolide. parthenolide 109-121 C-C motif chemokine ligand 2 Homo sapiens 39-44 24231355-3 2013 In primary human keratinocytes, we found that hypochlorite (HOCl) reversibly inhibited the expression of CCL2 and SOD2, two NF-kappaB-dependent genes. Hypochlorous Acid 46-58 C-C motif chemokine ligand 2 Homo sapiens 105-109 24231355-3 2013 In primary human keratinocytes, we found that hypochlorite (HOCl) reversibly inhibited the expression of CCL2 and SOD2, two NF-kappaB-dependent genes. Hypochlorous Acid 60-64 C-C motif chemokine ligand 2 Homo sapiens 105-109 24145706-4 2013 Notably, the levels of interleukin (IL)-1beta, IL-8 and monocyte chemotactic protein-1 (MCP-1) in the ELF were significantly increased following the operations which involved the inhalation of sevoflurane and nitrous oxide, although the levels of these molecules were not significantly changed by the inhalation of sevoflurane and air. Nitrous Oxide 209-222 C-C motif chemokine ligand 2 Homo sapiens 88-93 24145706-4 2013 Notably, the levels of interleukin (IL)-1beta, IL-8 and monocyte chemotactic protein-1 (MCP-1) in the ELF were significantly increased following the operations which involved the inhalation of sevoflurane and nitrous oxide, although the levels of these molecules were not significantly changed by the inhalation of sevoflurane and air. Sevoflurane 193-204 C-C motif chemokine ligand 2 Homo sapiens 56-86 24145706-4 2013 Notably, the levels of interleukin (IL)-1beta, IL-8 and monocyte chemotactic protein-1 (MCP-1) in the ELF were significantly increased following the operations which involved the inhalation of sevoflurane and nitrous oxide, although the levels of these molecules were not significantly changed by the inhalation of sevoflurane and air. Sevoflurane 193-204 C-C motif chemokine ligand 2 Homo sapiens 88-93 24145706-4 2013 Notably, the levels of interleukin (IL)-1beta, IL-8 and monocyte chemotactic protein-1 (MCP-1) in the ELF were significantly increased following the operations which involved the inhalation of sevoflurane and nitrous oxide, although the levels of these molecules were not significantly changed by the inhalation of sevoflurane and air. Sevoflurane 315-326 C-C motif chemokine ligand 2 Homo sapiens 56-86 24145706-4 2013 Notably, the levels of interleukin (IL)-1beta, IL-8 and monocyte chemotactic protein-1 (MCP-1) in the ELF were significantly increased following the operations which involved the inhalation of sevoflurane and nitrous oxide, although the levels of these molecules were not significantly changed by the inhalation of sevoflurane and air. Nitrous Oxide 209-222 C-C motif chemokine ligand 2 Homo sapiens 56-86 24145706-4 2013 Notably, the levels of interleukin (IL)-1beta, IL-8 and monocyte chemotactic protein-1 (MCP-1) in the ELF were significantly increased following the operations which involved the inhalation of sevoflurane and nitrous oxide, although the levels of these molecules were not significantly changed by the inhalation of sevoflurane and air. Sevoflurane 315-326 C-C motif chemokine ligand 2 Homo sapiens 88-93 24145706-6 2013 These observations suggest that the combination of sevoflurane and nitrous oxide induces an inflammatory response (increased production of IL-1beta, IL-8 and MCP-1) and suppresses the anti-inflammatory response (reduced production of IL-12p70) in the local milieu of the airway. Sevoflurane 51-62 C-C motif chemokine ligand 2 Homo sapiens 158-163 24145706-6 2013 These observations suggest that the combination of sevoflurane and nitrous oxide induces an inflammatory response (increased production of IL-1beta, IL-8 and MCP-1) and suppresses the anti-inflammatory response (reduced production of IL-12p70) in the local milieu of the airway. Nitrous Oxide 67-80 C-C motif chemokine ligand 2 Homo sapiens 158-163 24260297-11 2013 In human AAA tissues in ex vivo culture, MCP-1 secretion was dramatically suppressed by PF573228. 6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one 88-96 C-C motif chemokine ligand 2 Homo sapiens 41-46 24211328-4 2013 In stimulated human monocytes, micromolar Fluridone inhibited cyclooxygenase-2 expression and the release of monocyte chemoattractant protein-1 and prostaglandin-E2, to a similar extent as Acetylsalicylic acid. fluridone 42-51 C-C motif chemokine ligand 2 Homo sapiens 109-143 24649055-10 2013 The application of aspirin (0.1 mM) significantly inhibited the activation of ERK1/2 and NF-kappaB, the expression of TNF-alpha, IL-6, IL-1beta and MCP-1 genes and the secretion of TNF-alpha and IL-6. Aspirin 19-26 C-C motif chemokine ligand 2 Homo sapiens 148-153 24046362-3 2013 Short-term treatment with iodoacetamide mimicked experimental intestinal inflammation in IBD, as indicated by histological alterations such as hemorrhage, hyperemia and loss of regular crypt architecture, as well as enhanced expression of cytokines (e.g. IL-6, IL-10 and MCP-1) compared with control segments perfused with media. Iodoacetamide 26-39 C-C motif chemokine ligand 2 Homo sapiens 271-276 23974215-5 2013 Upon (32)P-labeling and vimentin immunoprecipitation, increased phosphorylation of vimentin was observed in MCP-1 treated monocytes as compared to the untreated monocytes. Phosphorus-32 5-10 C-C motif chemokine ligand 2 Homo sapiens 108-113 24061853-8 2013 Using SMD we confirm that molecular recognition in MCP1-IgG is based mainly on six pairs of residues: Glu39A - Arg98H, Lys56A - Asp52H, Asp65A - Arg32L, Asp68A - Arg32L, Thr32A - Glu55L, Gln61A - Tyr33H. asp68a 153-159 C-C motif chemokine ligand 2 Homo sapiens 51-55 23916117-7 2013 In cancer NAF samples (containing higher amounts of aluminium salts) we also found a significantly increased levels of pro-inflammatory cytokines (IL-1beta, IL-6, IL-12 p70, and TNF-alpha) and chemoattractant CC and CXC chemokines (IL-8, MIP-1alpha and MCP-1). aluminium salts 52-67 C-C motif chemokine ligand 2 Homo sapiens 253-258 23916117-8 2013 In 12 invasive cancer NAF samples we found a significant positive linear correlation among aluminium, carbonyls and pro-inflammatory IL-6 cytokine (Y = 64.79x-39.63, r(2) 0.8192, p < 0.0005), as well as pro-inflammatory monocyte chemoattractant MCP-1 cytokine (Y = 2026x-866, r(2) 0.9495, p < 0.0001). Aluminum 91-100 C-C motif chemokine ligand 2 Homo sapiens 248-253 24007780-5 2013 Following vitamin D loading at 3 months, the relationships between some of the cytokines changed (TNF-alpha and MCP-1: r=0.38, p=0.017, IL-1beta and IL-17: r=0.3, p=0.06). Vitamin D 10-19 C-C motif chemokine ligand 2 Homo sapiens 112-117 24061853-8 2013 Using SMD we confirm that molecular recognition in MCP1-IgG is based mainly on six pairs of residues: Glu39A - Arg98H, Lys56A - Asp52H, Asp65A - Arg32L, Asp68A - Arg32L, Thr32A - Glu55L, Gln61A - Tyr33H. glu39a 102-108 C-C motif chemokine ligand 2 Homo sapiens 51-55 24061853-8 2013 Using SMD we confirm that molecular recognition in MCP1-IgG is based mainly on six pairs of residues: Glu39A - Arg98H, Lys56A - Asp52H, Asp65A - Arg32L, Asp68A - Arg32L, Thr32A - Glu55L, Gln61A - Tyr33H. arg32l 162-168 C-C motif chemokine ligand 2 Homo sapiens 51-55 24061853-8 2013 Using SMD we confirm that molecular recognition in MCP1-IgG is based mainly on six pairs of residues: Glu39A - Arg98H, Lys56A - Asp52H, Asp65A - Arg32L, Asp68A - Arg32L, Thr32A - Glu55L, Gln61A - Tyr33H. arg98h 111-117 C-C motif chemokine ligand 2 Homo sapiens 51-55 24061853-8 2013 Using SMD we confirm that molecular recognition in MCP1-IgG is based mainly on six pairs of residues: Glu39A - Arg98H, Lys56A - Asp52H, Asp65A - Arg32L, Asp68A - Arg32L, Thr32A - Glu55L, Gln61A - Tyr33H. lys56a 119-125 C-C motif chemokine ligand 2 Homo sapiens 51-55 24061853-8 2013 Using SMD we confirm that molecular recognition in MCP1-IgG is based mainly on six pairs of residues: Glu39A - Arg98H, Lys56A - Asp52H, Asp65A - Arg32L, Asp68A - Arg32L, Thr32A - Glu55L, Gln61A - Tyr33H. thr32a 170-176 C-C motif chemokine ligand 2 Homo sapiens 51-55 24061853-8 2013 Using SMD we confirm that molecular recognition in MCP1-IgG is based mainly on six pairs of residues: Glu39A - Arg98H, Lys56A - Asp52H, Asp65A - Arg32L, Asp68A - Arg32L, Thr32A - Glu55L, Gln61A - Tyr33H. asp52h 128-134 C-C motif chemokine ligand 2 Homo sapiens 51-55 24061853-8 2013 Using SMD we confirm that molecular recognition in MCP1-IgG is based mainly on six pairs of residues: Glu39A - Arg98H, Lys56A - Asp52H, Asp65A - Arg32L, Asp68A - Arg32L, Thr32A - Glu55L, Gln61A - Tyr33H. glu55l 179-185 C-C motif chemokine ligand 2 Homo sapiens 51-55 24061853-8 2013 Using SMD we confirm that molecular recognition in MCP1-IgG is based mainly on six pairs of residues: Glu39A - Arg98H, Lys56A - Asp52H, Asp65A - Arg32L, Asp68A - Arg32L, Thr32A - Glu55L, Gln61A - Tyr33H. asp65a 136-142 C-C motif chemokine ligand 2 Homo sapiens 51-55 24061853-8 2013 Using SMD we confirm that molecular recognition in MCP1-IgG is based mainly on six pairs of residues: Glu39A - Arg98H, Lys56A - Asp52H, Asp65A - Arg32L, Asp68A - Arg32L, Thr32A - Glu55L, Gln61A - Tyr33H. arg32l 145-151 C-C motif chemokine ligand 2 Homo sapiens 51-55 24061853-8 2013 Using SMD we confirm that molecular recognition in MCP1-IgG is based mainly on six pairs of residues: Glu39A - Arg98H, Lys56A - Asp52H, Asp65A - Arg32L, Asp68A - Arg32L, Thr32A - Glu55L, Gln61A - Tyr33H. gln61a 187-193 C-C motif chemokine ligand 2 Homo sapiens 51-55 24061853-8 2013 Using SMD we confirm that molecular recognition in MCP1-IgG is based mainly on six pairs of residues: Glu39A - Arg98H, Lys56A - Asp52H, Asp65A - Arg32L, Asp68A - Arg32L, Thr32A - Glu55L, Gln61A - Tyr33H. tyr33h 196-202 C-C motif chemokine ligand 2 Homo sapiens 51-55 23494816-8 2013 We determined that the anti-allergy effects of acteoside were due to the down-regulation of the expressions of the chemokine ligand 1 (CCL1), CCL2, CCL3, CCL4, FCER1A and NFATC1 genes and the inhibition of the MAPK pathway through decreased JNK phosphorylation. acteoside 47-56 C-C motif chemokine ligand 2 Homo sapiens 142-146 23958343-10 2013 We found a novel function of edaravone is the promotion of tight junction formations of vascular endothelial cells partly via the down-regulation of MCP-1 secretion. Edaravone 29-38 C-C motif chemokine ligand 2 Homo sapiens 149-154 24091659-5 2013 Alcohol exposure enhanced acinar cell-specific production of TNFalpha, IL-6, MCP-1 and IL-10, as early as 3 h after LPS, whereas IL-18 and caspase-1 were evident 24 h later. Alcohols 0-7 C-C motif chemokine ligand 2 Homo sapiens 77-82 23515495-1 2013 We aimed to find the relationship between serum transforming growth factor beta 1(TGF-beta(1)) and urinary monocyte chemoattractant protein-1 (MCP-1) throughout the course of diabetic nephropathy (DN) and to assess the relationship between both levels and other parameters of renal injury such as albumin/creatinine ratio and estimated glomerular filtration rate (eGFR). Creatinine 305-315 C-C motif chemokine ligand 2 Homo sapiens 143-148 23792106-0 2013 Atorvastatin in stable angina patients lowers CCL2 and ICAM1 expression: pleiotropic evidence from plasma mRNA analyses. Atorvastatin 0-12 C-C motif chemokine ligand 2 Homo sapiens 46-50 23792106-6 2013 RESULTS: Atorvastatin lowered plasma mRNA levels (CCL2: -31.76%, p=0.037; ICAM1: -34.09%, p<0.001) and MCP-1 protein concentration (-18.88%, p=0.008) but did not lower sICAM-1 and sVCAM-1 protein concentrations, and the decreases appeared to be independent from the lowering of LDL-C. Atorvastatin 9-21 C-C motif chemokine ligand 2 Homo sapiens 50-54 23733596-9 2013 Results showed that supplementation with LC and Na2S reduced NF-kappaB phosphorylation and the secretion of TNF-alpha, MCP-1, IL-8, IL-1beta, and IP-10. sodium sulfide 48-52 C-C motif chemokine ligand 2 Homo sapiens 119-124 23279317-4 2013 RESULTS: Exposure to nicotine caused significant down-regulation in the expression of IL-10 (P = 0.046), growth-regulated oncogene (GRO)alpha (P = 0.036), MCP-1 (P = 0.046), and GMCSF (P = 0.004) compared with the control untreated HUVECs. Nicotine 21-29 C-C motif chemokine ligand 2 Homo sapiens 155-160 23726937-0 2013 Induction of monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 in primary sensory neurons contributes to paclitaxel-induced peripheral neuropathy. Paclitaxel 120-130 C-C motif chemokine ligand 2 Homo sapiens 13-47 23726937-0 2013 Induction of monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 in primary sensory neurons contributes to paclitaxel-induced peripheral neuropathy. Paclitaxel 120-130 C-C motif chemokine ligand 2 Homo sapiens 49-54 23726937-2 2013 Here we show that paclitaxel CIPN was associated with induction of chemokine monocyte chemoattractant protein-1 (MCP-1) and its cognate receptor CCR2 in primary sensory neurons of dorsal root ganglia. paclitaxel cipn 18-33 C-C motif chemokine ligand 2 Homo sapiens 77-111 23726937-2 2013 Here we show that paclitaxel CIPN was associated with induction of chemokine monocyte chemoattractant protein-1 (MCP-1) and its cognate receptor CCR2 in primary sensory neurons of dorsal root ganglia. paclitaxel cipn 18-33 C-C motif chemokine ligand 2 Homo sapiens 113-118 23726937-4 2013 Direct application of MCP-1 consistently induced intracellular calcium increases in dorsal root ganglia large and medium-sized neurons but not in small neurons mainly dissociated from paclitaxel-treated but not vehicle-treated animals. Calcium 63-70 C-C motif chemokine ligand 2 Homo sapiens 22-27 23726937-4 2013 Direct application of MCP-1 consistently induced intracellular calcium increases in dorsal root ganglia large and medium-sized neurons but not in small neurons mainly dissociated from paclitaxel-treated but not vehicle-treated animals. Paclitaxel 184-194 C-C motif chemokine ligand 2 Homo sapiens 22-27 23726937-5 2013 Paclitaxel also induced increased expression of MCP-1 in spinal astrocytes, but no CCR2 signal was detected in the spinal cord. Paclitaxel 0-10 C-C motif chemokine ligand 2 Homo sapiens 48-53 23726937-6 2013 Local blockade of MCP-1/CCR2 signaling by anti-MCP-1 antibody or CCR2 antisense oligodeoxynucleotides significantly attenuated paclitaxel CIPN phenotypes including mechanical hypersensitivity and loss of intraepidermal nerve fibers in hindpaw glabrous skin. paclitaxel cipn 127-142 C-C motif chemokine ligand 2 Homo sapiens 18-23 23726937-7 2013 These results suggest that activation of paracrine MCP-1/CCR2 signaling between dorsal root ganglion neurons plays a critical role in the development of paclitaxel CIPN, and targeting MCP-1/CCR2 signaling could be a novel therapeutic approach. paclitaxel cipn 153-168 C-C motif chemokine ligand 2 Homo sapiens 51-56 23726937-9 2013 The current study suggests that blocking MCP-1/CCR2 signaling could be a new therapeutic strategy to prevent or reverse paclitaxel CIPN. paclitaxel cipn 120-135 C-C motif chemokine ligand 2 Homo sapiens 41-46 23752092-4 2013 By performing electrophysiological experiments we have observed that, in cortical neurons MCP-1 (2-150 ng/ml) induced an enhancement of GABA-evoked currents that was significantly higher in G93A neurons compared to controls. gamma-Aminobutyric Acid 136-140 C-C motif chemokine ligand 2 Homo sapiens 90-95 23752092-5 2013 The effect of MCP-1 was not dependent on the activation of its receptor CCR2, while it was blocked by flumazenil, the antagonist of benzodiazepine sites. Flumazenil 102-112 C-C motif chemokine ligand 2 Homo sapiens 14-19 23752092-5 2013 The effect of MCP-1 was not dependent on the activation of its receptor CCR2, while it was blocked by flumazenil, the antagonist of benzodiazepine sites. Benzodiazepines 132-146 C-C motif chemokine ligand 2 Homo sapiens 14-19 23752092-7 2013 Instead, in cultured spinal neurons MCP-1 induced a significant reduction of GABA-evoked currents, also through the benzodiazepine sites, indicating a region-specific mechanism of action. gamma-Aminobutyric Acid 77-81 C-C motif chemokine ligand 2 Homo sapiens 36-41 23752092-7 2013 Instead, in cultured spinal neurons MCP-1 induced a significant reduction of GABA-evoked currents, also through the benzodiazepine sites, indicating a region-specific mechanism of action. Benzodiazepines 116-130 C-C motif chemokine ligand 2 Homo sapiens 36-41 23752092-9 2013 These findings provide the first evidence that MCP-1, acting on benzodiazepine sites, can modulate the GABA-evoked currents, depending on the subunit composition of GABA(A) receptor. Benzodiazepines 64-78 C-C motif chemokine ligand 2 Homo sapiens 47-52 23752092-9 2013 These findings provide the first evidence that MCP-1, acting on benzodiazepine sites, can modulate the GABA-evoked currents, depending on the subunit composition of GABA(A) receptor. gamma-Aminobutyric Acid 103-107 C-C motif chemokine ligand 2 Homo sapiens 47-52 23752092-9 2013 These findings provide the first evidence that MCP-1, acting on benzodiazepine sites, can modulate the GABA-evoked currents, depending on the subunit composition of GABA(A) receptor. gamma-Aminobutyric Acid 165-169 C-C motif chemokine ligand 2 Homo sapiens 47-52 23752092-10 2013 In cortical neurons MCP-1 upmodulates the GABA-evoked current and this effect is exacerbated in the mutated neurons. gamma-Aminobutyric Acid 42-46 C-C motif chemokine ligand 2 Homo sapiens 20-25 23752092-11 2013 It is reasonable to assume that the higher Cl(-) influx through GABA(A) receptors in the presence of MCP-1 in mutated cortical neurons may induce an excitotoxicity acceleration. gamma-Aminobutyric Acid 64-68 C-C motif chemokine ligand 2 Homo sapiens 101-106 24086554-0 2013 Febuxostat, an inhibitor of xanthine oxidase, suppresses lipopolysaccharide-induced MCP-1 production via MAPK phosphatase-1-mediated inactivation of JNK. Febuxostat 0-10 C-C motif chemokine ligand 2 Homo sapiens 84-89 24020822-6 2013 These data suggest that nanoencapsulated EGCG may have a potential to inhibit atherosclerotic lesion development through decreasing macrophage cholesterol content and MCP-1 expression. epigallocatechin gallate 41-45 C-C motif chemokine ligand 2 Homo sapiens 167-172 24086554-5 2013 Here we show that febuxostat suppresses LPS-induced MCP-1 production and mRNA expression via activating MAPK phosphatase-1 (MKP-1) which, in turn, leads to dephosphorylation and inactivation of JNK in macrophages. Febuxostat 18-28 C-C motif chemokine ligand 2 Homo sapiens 52-57 24086554-7 2013 Taken together, our data suggest that XO mediates LPS-induced phosphorylation of JNK through ROS production and MKP-1 inactivation, leading to MCP-1 production in macrophages. Reactive Oxygen Species 93-96 C-C motif chemokine ligand 2 Homo sapiens 143-148 23782265-5 2013 Both naringenin and flavone also effectively suppressed IL-6-stimulated phosphorylation of STAT3 (Tyr705) which led to suppression of IL-6-induction of the atherogenic STAT3 target gene MCP1 (monocyte chemotactic protein-1), suggesting that their ability to induce SOCS3 gene expression is STAT3-independent. naringenin 5-15 C-C motif chemokine ligand 2 Homo sapiens 186-190 22748497-5 2013 In contrast, resveratrol decreased the expression of pro-inflammatory genes IL-6 (interleukin-6) and MCP-1 (monocyte chemoattractant protein-1). Resveratrol 13-24 C-C motif chemokine ligand 2 Homo sapiens 101-106 22748497-5 2013 In contrast, resveratrol decreased the expression of pro-inflammatory genes IL-6 (interleukin-6) and MCP-1 (monocyte chemoattractant protein-1). Resveratrol 13-24 C-C motif chemokine ligand 2 Homo sapiens 108-142 24066150-7 2013 RESULTS: Roflumilast and Roflumilast-N-oxide concentration-dependently reduced the release of TNF-alpha and chemokines CCL2, CCL3, CCL4, CXCL9 and CXCL10 from LPS-stimulated human lung explants, whereas CXCL1, CXCL5 and CXCL8 release was not altered. roflumilast N-oxide 25-44 C-C motif chemokine ligand 2 Homo sapiens 119-123 23782265-5 2013 Both naringenin and flavone also effectively suppressed IL-6-stimulated phosphorylation of STAT3 (Tyr705) which led to suppression of IL-6-induction of the atherogenic STAT3 target gene MCP1 (monocyte chemotactic protein-1), suggesting that their ability to induce SOCS3 gene expression is STAT3-independent. naringenin 5-15 C-C motif chemokine ligand 2 Homo sapiens 192-222 23782265-5 2013 Both naringenin and flavone also effectively suppressed IL-6-stimulated phosphorylation of STAT3 (Tyr705) which led to suppression of IL-6-induction of the atherogenic STAT3 target gene MCP1 (monocyte chemotactic protein-1), suggesting that their ability to induce SOCS3 gene expression is STAT3-independent. flavone 20-27 C-C motif chemokine ligand 2 Homo sapiens 186-190 23782265-5 2013 Both naringenin and flavone also effectively suppressed IL-6-stimulated phosphorylation of STAT3 (Tyr705) which led to suppression of IL-6-induction of the atherogenic STAT3 target gene MCP1 (monocyte chemotactic protein-1), suggesting that their ability to induce SOCS3 gene expression is STAT3-independent. flavone 20-27 C-C motif chemokine ligand 2 Homo sapiens 192-222 23817641-5 2013 Higher (p < 0.05) concentrations of IL-6, IL-17 and MCP-1 were found in lipopolysaccharide-stimulated PBMC from RA patients compared to controls. PBMC 105-109 C-C motif chemokine ligand 2 Homo sapiens 55-60 23611517-6 2013 Serum creatinine at time of diagnosis had significant correlation with proteinuria (p = 0.02), urinary levels of IL-1beta (p = 0.03), IL-2 (p = 0.01) and MCP-1 (p = 0.03). Creatinine 6-16 C-C motif chemokine ligand 2 Homo sapiens 154-159 23913961-13 2013 In GAS-infected human THP-1 (macrophage-like) cells, PGE2 inhibited the production of MCP-1 and TNF-alpha while augmenting IL-10 expression. Dinoprostone 53-57 C-C motif chemokine ligand 2 Homo sapiens 86-91 26785981-3 2013 The use of adjunct biomarkers for TB diagnosis has been proposed, such as the chemokines: CXCL9, CXCL10 and CCL2. Terbium 34-36 C-C motif chemokine ligand 2 Homo sapiens 108-112 23629852-7 2013 Cobalt increased secretion of IL8 and MCP1 significantly, and upregulated the expression of ICAM-1 in ECs compared to stimulation by chromium and controls. Cobalt 0-6 C-C motif chemokine ligand 2 Homo sapiens 38-42 23662915-7 2013 RESULTS: Rebamipide could suppress polyI:C-induced cytokine production and the expression of mRNAs for CXCL10, CXCL11, RANTES, MCP-1, and IL-6 in human conjunctival epithelial cells. rebamipide 9-19 C-C motif chemokine ligand 2 Homo sapiens 127-132 24028188-6 2013 Simvastatin significantly attenuated TNF-alpha-induced CCL2 secretion without affecting CCL2 mRNA or protein expression. Simvastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 55-59 23683582-4 2013 CCL2-induced hyperalgesia was abolished by prior systemic leukocyte depletion by cyclophosphamide and was reconstituted by local adoptive transfer of donor macrophages but not of neutrophils. Cyclophosphamide 81-97 C-C motif chemokine ligand 2 Homo sapiens 0-4 23683582-7 2013 In vitro CCL2 did not directly stimulate Cox-2 expression or prostaglandin E2 formation but slightly enhanced the formation of reactive oxygen species in monocytes and macrophages. Reactive Oxygen Species 127-150 C-C motif chemokine ligand 2 Homo sapiens 9-13 23661232-0 2013 Inhibitory effects of resveratrol on MCP-1, IL-6, and IL-8 production in human coronary artery smooth muscle cells. Resveratrol 22-33 C-C motif chemokine ligand 2 Homo sapiens 37-42 23661232-5 2013 Basal levels of monocyte chemoattractant protein-1 (MCP-1), interleukin (IL)-6, and IL-8 were significantly decreased in the presence of resveratrol at 1-50 muM in a concentration-dependent manner and were significantly decreased in the presence of U0126, an ERK inhibitor. Resveratrol 137-148 C-C motif chemokine ligand 2 Homo sapiens 16-50 23661232-6 2013 Resveratrol significantly decreased both basal and interferon-gamma (IFN-gamma) (200 ng/ml)-stimulated levels of MCP-1, IL-6, and IL-8 and significantly attenuated both basal and IFN-gamma-stimulated activity of ERK. Resveratrol 0-11 C-C motif chemokine ligand 2 Homo sapiens 113-118 23661232-8 2013 Therefore, resveratrol is thought to inhibit production of MCP-1, IL-6, and IL-8 in HCASMCs through attenuating ERK activity. Resveratrol 11-22 C-C motif chemokine ligand 2 Homo sapiens 59-64 23661232-5 2013 Basal levels of monocyte chemoattractant protein-1 (MCP-1), interleukin (IL)-6, and IL-8 were significantly decreased in the presence of resveratrol at 1-50 muM in a concentration-dependent manner and were significantly decreased in the presence of U0126, an ERK inhibitor. Resveratrol 137-148 C-C motif chemokine ligand 2 Homo sapiens 52-57 23831464-0 2013 Differential regulation of CC chemokine ligand 2 and CXCL8 by antifungal agent nystatin in macrophages. Nystatin 79-87 C-C motif chemokine ligand 2 Homo sapiens 27-48 23967234-0 2013 Amniotic fluid stem cells inhibit the progression of bleomycin-induced pulmonary fibrosis via CCL2 modulation in bronchoalveolar lavage. Bleomycin 53-62 C-C motif chemokine ligand 2 Homo sapiens 94-98 23967234-8 2013 CCL2 expression increased in bleomycin-injured bronchoalveolar lavage (BAL), but significantly decreased following AFSC treatment at either day 0 or at day 14. Bleomycin 29-38 C-C motif chemokine ligand 2 Homo sapiens 0-4 23831464-4 2013 However, nystatin dose-dependently increased CCL2 and CXCL8 expression at the mRNA and protein levels. Nystatin 9-17 C-C motif chemokine ligand 2 Homo sapiens 45-49 23831464-5 2013 To understand the molecular mechanisms of the antifungal agent, we identified cellular factors activated by nystatin and those involved in nystatin-induced upregulation of CCL2 and CXCL8. Nystatin 139-147 C-C motif chemokine ligand 2 Homo sapiens 172-176 23831464-7 2013 Treatment with cholesterol, LY294002, Akt inhibitor IV, U0126, and SP6001250 resulted in abrogation or significant attenuation of nystatin-induced CCL2 expression. Cholesterol 15-26 C-C motif chemokine ligand 2 Homo sapiens 147-151 23831464-7 2013 Treatment with cholesterol, LY294002, Akt inhibitor IV, U0126, and SP6001250 resulted in abrogation or significant attenuation of nystatin-induced CCL2 expression. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 28-36 C-C motif chemokine ligand 2 Homo sapiens 147-151 21997325-9 2013 "In vitro" results demonstrate that glucose directly and significantly induced MCP-1 and IL6 and reduced TLR2 mRNA expression. Glucose 36-43 C-C motif chemokine ligand 2 Homo sapiens 79-84 23831464-7 2013 Treatment with cholesterol, LY294002, Akt inhibitor IV, U0126, and SP6001250 resulted in abrogation or significant attenuation of nystatin-induced CCL2 expression. U 0126 56-61 C-C motif chemokine ligand 2 Homo sapiens 147-151 21997325-10 2013 Insulin at high dose (100 IU/ml) dramatically enhanced the upregulatory effects of glucose on MCP-1 and IL-6 and reduced per se TLR2 mRNA expression. Glucose 83-90 C-C motif chemokine ligand 2 Homo sapiens 94-99 23831464-7 2013 Treatment with cholesterol, LY294002, Akt inhibitor IV, U0126, and SP6001250 resulted in abrogation or significant attenuation of nystatin-induced CCL2 expression. sp6001250 67-76 C-C motif chemokine ligand 2 Homo sapiens 147-151 23831464-7 2013 Treatment with cholesterol, LY294002, Akt inhibitor IV, U0126, and SP6001250 resulted in abrogation or significant attenuation of nystatin-induced CCL2 expression. Nystatin 130-138 C-C motif chemokine ligand 2 Homo sapiens 147-151 23831464-9 2013 These results indicate that exposure of human macrophages to nystatin can lead to differential regulation of CCL2 and CXCL8 via the activation of multiple cellular kinases. Nystatin 61-69 C-C motif chemokine ligand 2 Homo sapiens 109-113 23831464-10 2013 We propose that upregulation of CCL2 and CXCL8 contributes to pharmacological effects of nystatin. Nystatin 89-97 C-C motif chemokine ligand 2 Homo sapiens 32-36 23559389-4 2013 Significantly high IL-1beta, IL-6, TNF-alpha, CXCL10, and CCL2 in MC + HCV vs healthy controls were confirmed. Methylcholanthrene 66-68 C-C motif chemokine ligand 2 Homo sapiens 58-62 23559389-6 2013 This study demonstrates in MC + HCV high serum levels of (a) T-helper 1 chemokines, CXCL11 and CXCL10 (related to each other) and (b) proinflammatory cytokines IL-6 and CCL2 (related to each other). Methylcholanthrene 27-31 C-C motif chemokine ligand 2 Homo sapiens 169-173 23624000-2 2013 Moreover, Tregs induced upregulation of profibrogenic markers TIMP1, MMP2, TGF-beta1, alpha-SMA, collagen, and CCL2 in primary human hepatic stellate cells (HSC). tregs 10-15 C-C motif chemokine ligand 2 Homo sapiens 111-115 23649946-5 2013 We review studies showing a relationship between elevated aqueous VEGF, monocyte chemoattractant protein -1, interleukin 6, or interleukin 8 in association with DME and as predictors of DME. dme 161-164 C-C motif chemokine ligand 2 Homo sapiens 72-107 23794630-5 2013 We report in this article that downstream depletion of geranylgeranyl pyrophosphate (GGPP), which is required for protein prenylation, caused cell stress in monocytes, followed by caspase-1-mediated maturation and release of IL-18, which, in turn, induced gammadelta T cell CCL2. geranylgeranyl pyrophosphate 55-83 C-C motif chemokine ligand 2 Homo sapiens 274-278 23794630-5 2013 We report in this article that downstream depletion of geranylgeranyl pyrophosphate (GGPP), which is required for protein prenylation, caused cell stress in monocytes, followed by caspase-1-mediated maturation and release of IL-18, which, in turn, induced gammadelta T cell CCL2. geranylgeranyl pyrophosphate 85-89 C-C motif chemokine ligand 2 Homo sapiens 274-278 23670941-3 2013 DESIGN AND METHODS: We compared signal transduction pathways regulating VEGF with those regulating monocyte chemoattractant protein-1 (MCP-1), which is increased in obese adipocytes, in an in vitro model of artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate, without the influence of hypoxia. Palmitates 267-276 C-C motif chemokine ligand 2 Homo sapiens 135-140 23670941-4 2013 RESULTS: Palmitate-preloaded cells exhibited significantly enhanced oxidative stress (P < 0.01) and showed increased VEGF120 and MCP-1 release (P < 0.01, respectively), while endoplasmic reticulum (ER) stress was not induced. Palmitates 9-18 C-C motif chemokine ligand 2 Homo sapiens 132-137 23670941-7 2013 In contrast, increased MCP-1 release was suppressed with JNK inhibitor SP600125 and p38 MAPK inhibitor SB203580 (P < 0.01). pyrazolanthrone 71-79 C-C motif chemokine ligand 2 Homo sapiens 23-28 23670941-7 2013 In contrast, increased MCP-1 release was suppressed with JNK inhibitor SP600125 and p38 MAPK inhibitor SB203580 (P < 0.01). SB 203580 103-111 C-C motif chemokine ligand 2 Homo sapiens 23-28 23715591-5 2013 The rate of chlorinated ethylene substrate decay increased with increasing substrate chlorination in the order CH2=CHCl < cis-CHCl=CHCl < trans-CHCl=CHCl < CCl2=CHCl. ethylene 24-32 C-C motif chemokine ligand 2 Homo sapiens 165-169 23712703-4 2013 However, the receptor for advanced glycation end products (RAGE) blocker RAGE-Ab (5 mug/ml) or 10 muM c-Jun N-terminal kinases (JNK) inhibitor SP600125 could inhibit HMGB1-induced the release of inflammation cytokines including TNF-alpha, IL-8, IL-10, and MCP-1 in a dose-dependent manner. pyrazolanthrone 143-151 C-C motif chemokine ligand 2 Homo sapiens 256-261 23562973-8 2013 All retinoids tested stimulated release of the anti-inflammatory cytokines granulocyte-macrophage colony-stimulating factor and IL-10, and also monocyte chemotactic protein-1, vascular endothelial growth factor and eotaxin-1. Retinoids 4-13 C-C motif chemokine ligand 2 Homo sapiens 144-174 23936148-0 2013 Effect of folic acid supplementation on levels of circulating Monocyte Chemoattractant Protein-1 and the presence of intravascular ultrasound derived virtual histology thin-cap fibroatheromas in patients with stable angina pectoris. Folic Acid 10-20 C-C motif chemokine ligand 2 Homo sapiens 62-96 23936148-2 2013 Monocyte Chemoattractant Protein-1 (MCP-1) is linked with coronary atherosclerosis and plaque instability and could potentially be modified by folic acid treatment. Folic Acid 143-153 C-C motif chemokine ligand 2 Homo sapiens 0-34 23936148-2 2013 Monocyte Chemoattractant Protein-1 (MCP-1) is linked with coronary atherosclerosis and plaque instability and could potentially be modified by folic acid treatment. Folic Acid 143-153 C-C motif chemokine ligand 2 Homo sapiens 36-41 23936148-6 2013 RESULTS: Patients treated with folic acid/vitamin B12 had a geometric mean (SD) MCP-1 level of 79.95 (1.49) versus 86.00 (1.43) pg/mL for patients receiving placebo (p-value 0.34). Folic Acid 31-41 C-C motif chemokine ligand 2 Homo sapiens 80-85 23936148-6 2013 RESULTS: Patients treated with folic acid/vitamin B12 had a geometric mean (SD) MCP-1 level of 79.95 (1.49) versus 86.00 (1.43) pg/mL for patients receiving placebo (p-value 0.34). Vitamin B 12 42-53 C-C motif chemokine ligand 2 Homo sapiens 80-85 23936148-8 2013 Serum levels of MCP-1 were 1.46 (95% CI 1.12 to 1.92) times higher in patients with VH-TCFA lesions than in those without (p-value 0.005). tcfa 87-91 C-C motif chemokine ligand 2 Homo sapiens 16-21 23936148-11 2013 MCP-1 is however associated with VH-TCFA, a finding corroborated by increased risk for future MI. tcfa 36-40 C-C motif chemokine ligand 2 Homo sapiens 0-5 23770363-0 2013 Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes. Vitamin D 0-9 C-C motif chemokine ligand 2 Homo sapiens 116-121 23770363-7 2013 1,25 (OH)2 vitamin D caused significantly (p<0.05) lower secretion of IL-8 and MCP-1, and lower ROS levels in monocytes exposed to control and HG-treated monocytes. 1,25 (oh)2 vitamin d 0-20 C-C motif chemokine ligand 2 Homo sapiens 82-87 23683858-4 2013 ppTGRL were found to increase the secretion of chemoattractants, including monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1alpha and -1beta and IL-8, by HMDM and to have a stimulatory effect on monocyte chemotaxis. pptgrl 0-6 C-C motif chemokine ligand 2 Homo sapiens 75-109 23772028-10 2013 We also show that LPS, through p38 MAPK signaling, induces phosphorylation of GRK2 at serine 670, which, in turn, suppresses GRK2 translocation to the membrane, thereby preventing GRK2-initiated internalization and desensitization of CCR2 in response to MCP-1. Serine 86-92 C-C motif chemokine ligand 2 Homo sapiens 254-259 23845159-8 2013 CCL2 bound to CS chains of versican and colocalized with versican in the monocytes" Golgi apparatus. Chondroitin Sulfates 14-16 C-C motif chemokine ligand 2 Homo sapiens 0-4 22975282-5 2013 This review focuses on recent evidence that the Ca(v)3 subunits of T-type channels, Ca(v)3.1, Ca(v)3.2 and Ca(v)3.3, are differentially modulated by a multitude of endogenous ligands including anandamide, monocyte chemoattractant protein-1, endostatin, and redox and oxidizing agents. anandamide 193-203 C-C motif chemokine ligand 2 Homo sapiens 205-239 23845159-9 2013 Finally, CCL2 had a greater ability to mediate monocyte migration when bound to CS chains, because this binding provided efficient formation of CCL2 gradients and protection from protease attack. Chondroitin Sulfates 80-82 C-C motif chemokine ligand 2 Homo sapiens 9-13 23845159-9 2013 Finally, CCL2 had a greater ability to mediate monocyte migration when bound to CS chains, because this binding provided efficient formation of CCL2 gradients and protection from protease attack. Chondroitin Sulfates 80-82 C-C motif chemokine ligand 2 Homo sapiens 144-148 23604718-4 2013 We found that SsnB dose-dependently attenuated the LPS-induced expression of interleukin (IL)-1beta and monocyte chemoattractant protein 1 both at the transcription and translation levels in HUVEC. sparstolonin B 14-18 C-C motif chemokine ligand 2 Homo sapiens 104-138 23807419-11 2013 In addition, both BPs strongly influenced the secretion of the chemokine CCL2 by osteoblasts. Diphosphonates 18-21 C-C motif chemokine ligand 2 Homo sapiens 73-77 23683858-4 2013 ppTGRL were found to increase the secretion of chemoattractants, including monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1alpha and -1beta and IL-8, by HMDM and to have a stimulatory effect on monocyte chemotaxis. pptgrl 0-6 C-C motif chemokine ligand 2 Homo sapiens 111-116 23297114-5 2013 In endothelial cells, H2 S treatment reduces the increase in MCP-1, inter-cellular adhesion molecule-1, vascular cell adhesion molecule-1, and of a disintegrin and metalloproteinase metallopeptidase domain 17 (ADAM17), both at the gene expression and protein levels. Hydrogen 22-24 C-C motif chemokine ligand 2 Homo sapiens 61-137 23364255-9 2013 Plasma levels of hs-CRP, IL-6, and MCP-1 increased significantly after PCI in both the rosuvastatin and control groups; however, the postprocedural elevations in hs-CRP and IL-6 levels were significantly lower in the rosuvastatin group than the control group. Rosuvastatin Calcium 87-99 C-C motif chemokine ligand 2 Homo sapiens 35-40 23297114-7 2013 In addition, H2S significantly reduces activation of ADAM17 by PMA in endothelial cells, with consequent reduction of both ADAM17-dependent TNF-alpha ectodomain shedding and MCP-1 release. Hydrogen Sulfide 13-16 C-C motif chemokine ligand 2 Homo sapiens 174-179 23667177-4 2013 A human MCP-1 mutant in which basic amino acids Arg-18 and Lys-19 were replaced with Ala did not bind to OxLDL. Amino Acids, Basic 30-47 C-C motif chemokine ligand 2 Homo sapiens 8-13 23667177-5 2013 The MCP-1 binding to OxLDL was inhibited by the monoclonal antibody E06, which binds oxidized phospholipids (OxPLs) in OxLDL. Phospholipids 94-107 C-C motif chemokine ligand 2 Homo sapiens 4-9 23667177-5 2013 The MCP-1 binding to OxLDL was inhibited by the monoclonal antibody E06, which binds oxidized phospholipids (OxPLs) in OxLDL. oxpls 109-114 C-C motif chemokine ligand 2 Homo sapiens 4-9 23423499-4 2013 Melanin uptake increased the secretion of the chemokines MIP-1beta (CCL4) and MCP-1 (CCL2). Melanins 0-7 C-C motif chemokine ligand 2 Homo sapiens 78-83 23490191-12 2013 Both before and after IVTA, MCP-1 was higher in eyes with macula-off RRD than in eyes with macula-on RRD. ivta 22-26 C-C motif chemokine ligand 2 Homo sapiens 28-33 23490191-13 2013 CONCLUSIONS: IVTA suppressed elevated levels of intraocular MCP-1, MIP-1beta, and IP-10 in eyes with RRD. ivta 13-17 C-C motif chemokine ligand 2 Homo sapiens 60-65 23585426-0 2013 Indole-3-carbinol and 3",3"-diindolylmethane modulate androgen"s effect on C-C chemokine ligand 2 and monocyte attraction to prostate cancer cells. indole-3-carbinol 0-17 C-C motif chemokine ligand 2 Homo sapiens 75-97 23585426-0 2013 Indole-3-carbinol and 3",3"-diindolylmethane modulate androgen"s effect on C-C chemokine ligand 2 and monocyte attraction to prostate cancer cells. 3,3'-diindolylmethane 22-44 C-C motif chemokine ligand 2 Homo sapiens 75-97 23585426-5 2013 Dihydrotestosterone was found to induce a time-dependent (0-72 hours) and concentration-dependent (0-1 nmol/L) increase in CCL2 mRNA levels in androgen-responsive human prostate cancer cells (LNCaP). Dihydrotestosterone 0-19 C-C motif chemokine ligand 2 Homo sapiens 123-127 23585426-7 2013 The effect of dihydrotestosterone was mediated through an androgen receptor (AR)-dependent pathway as small inhibitor RNA against AR negated the induction of CCL2. Dihydrotestosterone 14-33 C-C motif chemokine ligand 2 Homo sapiens 158-162 23585426-8 2013 Although dihydrotestosterone also induced TWIST1 mRNA, an epithelial-mesenchymal transition-related factor, and purported inducer of CCL2, blocking its expression with small inhibitor RNA did not inhibit dihydrotestosterone induction of CCL2 mRNA. Dihydrotestosterone 9-28 C-C motif chemokine ligand 2 Homo sapiens 133-137 23585426-10 2013 Both I3C and DIM inhibited promotional effects of dihydrotestosterone on CCL2 and migration. Dihydrotestosterone 50-69 C-C motif chemokine ligand 2 Homo sapiens 73-77 24063213-9 2013 The serum CRP and MCP-1 levels were significantly higher in Group OBT, NOBT, and OBNT than in Group P (P < 0.05, P < 0.01). nobt 71-75 C-C motif chemokine ligand 2 Homo sapiens 18-23 23423499-4 2013 Melanin uptake increased the secretion of the chemokines MIP-1beta (CCL4) and MCP-1 (CCL2). Melanins 0-7 C-C motif chemokine ligand 2 Homo sapiens 85-89 23262985-9 2013 CONCLUSIONS: Propofol at clinically relevant concentrations attenuated LPS-induced MCP-1 mRNA expression and secretion by inhibiting the phosphorylation of p38 MAPK, SAPK/JNK, ATF-2, and c-Jun exerting its anti-inflammatory effects in AECs. Propofol 13-21 C-C motif chemokine ligand 2 Homo sapiens 83-88 23600826-5 2013 Co-incubation of fatty acids with uric acid resulted in a significant reduction of IL-10, IL-12(p70), IFN-gamma and CCL2 (MCP-1) concentrations in supernatants compared to incubation with uric acid alone (P < 0 0001). Fatty Acids 17-28 C-C motif chemokine ligand 2 Homo sapiens 116-120 23600826-5 2013 Co-incubation of fatty acids with uric acid resulted in a significant reduction of IL-10, IL-12(p70), IFN-gamma and CCL2 (MCP-1) concentrations in supernatants compared to incubation with uric acid alone (P < 0 0001). Fatty Acids 17-28 C-C motif chemokine ligand 2 Homo sapiens 122-127 23600826-5 2013 Co-incubation of fatty acids with uric acid resulted in a significant reduction of IL-10, IL-12(p70), IFN-gamma and CCL2 (MCP-1) concentrations in supernatants compared to incubation with uric acid alone (P < 0 0001). Uric Acid 34-43 C-C motif chemokine ligand 2 Homo sapiens 116-120 23600826-5 2013 Co-incubation of fatty acids with uric acid resulted in a significant reduction of IL-10, IL-12(p70), IFN-gamma and CCL2 (MCP-1) concentrations in supernatants compared to incubation with uric acid alone (P < 0 0001). Uric Acid 34-43 C-C motif chemokine ligand 2 Homo sapiens 122-127 23262985-0 2013 Propofol attenuates lipopolysaccharide-induced monocyte chemoattractant protein-1 production through p38 MAPK and SAPK/JNK in alveolar epithelial cells. Propofol 0-8 C-C motif chemokine ligand 2 Homo sapiens 47-81 23262985-3 2013 The present study investigated the anti-inflammatory effect and mechanism of propofol on MCP-1 production and mitogen-activated protein kinase (MAPK) phosphorylation induced by lipopolysaccharide (LPS) in alveolar epithelial cells (AECs). Propofol 77-85 C-C motif chemokine ligand 2 Homo sapiens 89-94 23600826-7 2013 Similarly, co-incubation of fatty acids with glucose diminished secretion of IL-10, IFN-gamma and CCL2 (monocyte chemotactic protein-1), while IL-8 was up-regulated (P < 0 001). Fatty Acids 28-39 C-C motif chemokine ligand 2 Homo sapiens 98-102 23600826-7 2013 Similarly, co-incubation of fatty acids with glucose diminished secretion of IL-10, IFN-gamma and CCL2 (monocyte chemotactic protein-1), while IL-8 was up-regulated (P < 0 001). Fatty Acids 28-39 C-C motif chemokine ligand 2 Homo sapiens 104-134 23600826-7 2013 Similarly, co-incubation of fatty acids with glucose diminished secretion of IL-10, IFN-gamma and CCL2 (monocyte chemotactic protein-1), while IL-8 was up-regulated (P < 0 001). Glucose 45-52 C-C motif chemokine ligand 2 Homo sapiens 98-102 23600826-7 2013 Similarly, co-incubation of fatty acids with glucose diminished secretion of IL-10, IFN-gamma and CCL2 (monocyte chemotactic protein-1), while IL-8 was up-regulated (P < 0 001). Glucose 45-52 C-C motif chemokine ligand 2 Homo sapiens 104-134 22492174-9 2013 Acute application of pCB significantly inhibited both the basal and CCL2-stimulated migration of monocytes, but only in subjects non-naive to Cannabis. pcb 21-24 C-C motif chemokine ligand 2 Homo sapiens 68-72 23262985-7 2013 RESULTS: Propofol at 50 and 100 muM dose-dependently inhibited MCP-1 mRNA expression (P < 0.05), and also propofol at 50 muM decreased extracellular MCP-1 protein levels (P < 0.05) compared to the LPS group. Propofol 9-17 C-C motif chemokine ligand 2 Homo sapiens 63-68 23262985-7 2013 RESULTS: Propofol at 50 and 100 muM dose-dependently inhibited MCP-1 mRNA expression (P < 0.05), and also propofol at 50 muM decreased extracellular MCP-1 protein levels (P < 0.05) compared to the LPS group. Propofol 9-17 C-C motif chemokine ligand 2 Homo sapiens 152-157 23262985-7 2013 RESULTS: Propofol at 50 and 100 muM dose-dependently inhibited MCP-1 mRNA expression (P < 0.05), and also propofol at 50 muM decreased extracellular MCP-1 protein levels (P < 0.05) compared to the LPS group. Propofol 109-117 C-C motif chemokine ligand 2 Homo sapiens 152-157 23204548-5 2013 CONCLUSION: Hyperuricaemia causes elevated serum CCL2 levels and increased monocyte recruitment that may be driven by soluble uric acid-induced CCL2 production. Uric Acid 126-135 C-C motif chemokine ligand 2 Homo sapiens 49-53 23204548-5 2013 CONCLUSION: Hyperuricaemia causes elevated serum CCL2 levels and increased monocyte recruitment that may be driven by soluble uric acid-induced CCL2 production. Uric Acid 126-135 C-C motif chemokine ligand 2 Homo sapiens 144-148 23542035-2 2013 We show that sustained LPS or poly(I:C)-stimulated MCP-1 production requires an IFNbeta-mediated feedback loop. Poly I-C 30-39 C-C motif chemokine ligand 2 Homo sapiens 51-56 23542035-4 2013 Blocking IFNbeta signaling with Ruxolitinib, a JAK inhibitor, inhibited MCP-1 transcription. ruxolitinib 32-43 C-C motif chemokine ligand 2 Homo sapiens 72-77 23328126-8 2013 The addition of omega-3 fatty acids reduced MCP-1 expression with no effect on TNF-alpha. Fatty Acids, Omega-3 16-35 C-C motif chemokine ligand 2 Homo sapiens 44-49 23971693-9 2013 We predict that cholecalciferol will attenuate hypertension, proteinuria and reduce the urinary excretion of a biomarker, monocyte chemoattractant protein-1 (MCP-1, a surrogate inflammatory marker of progression in ADPKD). Cholecalciferol 16-31 C-C motif chemokine ligand 2 Homo sapiens 122-156 23971693-9 2013 We predict that cholecalciferol will attenuate hypertension, proteinuria and reduce the urinary excretion of a biomarker, monocyte chemoattractant protein-1 (MCP-1, a surrogate inflammatory marker of progression in ADPKD). Cholecalciferol 16-31 C-C motif chemokine ligand 2 Homo sapiens 158-163 23541900-0 2013 Impact of telmisartan on the inflammatory state in patients with coronary atherosclerosis--influence on IP-10, TNF-alpha and MCP-1. Telmisartan 10-21 C-C motif chemokine ligand 2 Homo sapiens 125-130 23541900-11 2013 MCP-1 (P=0.001; P<0.001) was increased significantly in both telmisartan and control group. Telmisartan 64-75 C-C motif chemokine ligand 2 Homo sapiens 0-5 23328126-9 2013 In addition, omega-3 fatty acids suppressed the upregulation of adipocyte MCP-1 that occurred when adipocytes were cocultured with macrophages. Fatty Acids, Omega-3 13-32 C-C motif chemokine ligand 2 Homo sapiens 74-79 23402987-2 2013 We hypothesized that MCP-1 might impair the reverse cholesterol transport (RCT) capacity of HepG2 cells by decreasing the cell-surface protein expression of ATP binding cassette A1 (ABCA1), ATP binding cassette G1 (ABCG1), and scavenger receptor class B type I (SR-BI). Cholesterol 52-63 C-C motif chemokine ligand 2 Homo sapiens 21-26 23536633-6 2013 Further, blockade of fatty-acid synthesis decreased DC expression of MHC class II, ICAM-1, B7-1, and B7-2 but increased their production of selected proinflammatory cytokines including IL-12 and MCP-1. Fatty Acids 21-31 C-C motif chemokine ligand 2 Homo sapiens 195-200 23402987-8 2013 Moreover, we found that MCP-1 decreased the lipid uptake by HepG2 cells and the ABCA1-mediated cholesterol efflux to apoA-I, which could be reversed by PI3K activation. Cholesterol 95-106 C-C motif chemokine ligand 2 Homo sapiens 24-29 23549806-1 2013 PURPOSE: Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that can increase adhesion molecule expression on monocytes and produce superoxide anions. Superoxides 139-156 C-C motif chemokine ligand 2 Homo sapiens 9-43 23549806-1 2013 PURPOSE: Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that can increase adhesion molecule expression on monocytes and produce superoxide anions. Superoxides 139-156 C-C motif chemokine ligand 2 Homo sapiens 45-50 23616769-8 2013 EGCG inhibited interleukin (IL)-1beta, transforming growth factor beta, IL-8, and chemokine (C-C motif) ligand 2 (CCL2) release by stimulated FLS and/or THP-1 cells in a dose-dependent manner. epigallocatechin gallate 0-4 C-C motif chemokine ligand 2 Homo sapiens 82-112 23616769-8 2013 EGCG inhibited interleukin (IL)-1beta, transforming growth factor beta, IL-8, and chemokine (C-C motif) ligand 2 (CCL2) release by stimulated FLS and/or THP-1 cells in a dose-dependent manner. epigallocatechin gallate 0-4 C-C motif chemokine ligand 2 Homo sapiens 114-118 23616769-11 2013 Furthermore, MbetaCD enhanced the inflammatory response to CPP crystals increasing IL-8 and CCL2 secretion which was inhibited by EGCG in a dose-dependent manner. methyl-beta-cyclodextrin 13-20 C-C motif chemokine ligand 2 Homo sapiens 92-96 23616769-11 2013 Furthermore, MbetaCD enhanced the inflammatory response to CPP crystals increasing IL-8 and CCL2 secretion which was inhibited by EGCG in a dose-dependent manner. epigallocatechin gallate 130-134 C-C motif chemokine ligand 2 Homo sapiens 92-96 23466098-7 2013 An inverse association was also observed between 14,15-EET:DHET ratios (a biomarker of sEH metabolism) and both monocyte chemoattractant protein-1 levels (r = -0.252, p = 0.009) and a consolidated cellular adhesion molecule "score" reflecting the levels of E-selectin and P-selectin (r = -0.216, p = 0.027). dhet 59-63 C-C motif chemokine ligand 2 Homo sapiens 112-146 23408426-0 2013 Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1). Tyrosine 0-8 C-C motif chemokine ligand 2 Homo sapiens 123-157 23408426-0 2013 Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1). Tyrosine 0-8 C-C motif chemokine ligand 2 Homo sapiens 159-164 23408426-2 2013 We have investigated the effect of tyrosine sulfation of the chemokine receptor CCR2 on its interactions with the chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). Tyrosine 35-43 C-C motif chemokine ligand 2 Homo sapiens 124-158 23408426-2 2013 We have investigated the effect of tyrosine sulfation of the chemokine receptor CCR2 on its interactions with the chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). Tyrosine 35-43 C-C motif chemokine ligand 2 Homo sapiens 160-165 23408426-2 2013 We have investigated the effect of tyrosine sulfation of the chemokine receptor CCR2 on its interactions with the chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). Tyrosine 35-43 C-C motif chemokine ligand 2 Homo sapiens 166-170 23408426-3 2013 Inhibition of CCR2 sulfation, by growth of expressing cells in the presence of sodium chlorate, significantly reduced the potency for MCP-1 activation of CCR2. sodium chlorate 79-94 C-C motif chemokine ligand 2 Homo sapiens 134-139 23557144-4 2013 METHODS: On the grounds of preliminary investigations in 252 patients with alum-associated ASIA showing both a selective increase of circulating CCL2, the major monocyte chemoattractant, and a variation in the CCL2 gene, we designed mouse experiments to assess biodistribution of vaccine-derived aluminum and of alum-particle fluorescent surrogates injected in muscle. aluminum sulfate 75-79 C-C motif chemokine ligand 2 Homo sapiens 145-149 23557144-4 2013 METHODS: On the grounds of preliminary investigations in 252 patients with alum-associated ASIA showing both a selective increase of circulating CCL2, the major monocyte chemoattractant, and a variation in the CCL2 gene, we designed mouse experiments to assess biodistribution of vaccine-derived aluminum and of alum-particle fluorescent surrogates injected in muscle. aluminum sulfate 75-79 C-C motif chemokine ligand 2 Homo sapiens 210-214 23557144-11 2013 Loss/gain-of-function experiments consistently implicated CCL2 in systemic diffusion of Al-Rho particles captured by monocyte-lineage cells and in their subsequent neurodelivery. Aluminum 88-90 C-C motif chemokine ligand 2 Homo sapiens 58-62 23557387-0 2013 Chemokine (C-C motif) Ligand 2 is a potential biomarker of inflammation & physical fitness in obese children: a cross-sectional study. Adenosine Monophosphate 73-76 C-C motif chemokine ligand 2 Homo sapiens 0-30 23380242-10 2013 TiO2 NPs also significantly increased induction of mRNA and protein levels of vascular cell adhesion molecule-1 (VCAM-1) and mRNA levels of monocyte chemoattractant protein-1 (MCP-1). titanium dioxide 0-4 C-C motif chemokine ligand 2 Homo sapiens 140-174 23380242-10 2013 TiO2 NPs also significantly increased induction of mRNA and protein levels of vascular cell adhesion molecule-1 (VCAM-1) and mRNA levels of monocyte chemoattractant protein-1 (MCP-1). titanium dioxide 0-4 C-C motif chemokine ligand 2 Homo sapiens 176-181 23593194-8 2013 In addition, high-salt intake was associated with progressive hypoxia in the renal medulla (increased R2* signal) and enhanced urinary monocyte chemoattractant protein-1 (MCP-1) excretion, indicating a temporal and spatial correlation between CD14++CD16+ subset and renal inflammation. Salts 18-22 C-C motif chemokine ligand 2 Homo sapiens 135-169 23593194-8 2013 In addition, high-salt intake was associated with progressive hypoxia in the renal medulla (increased R2* signal) and enhanced urinary monocyte chemoattractant protein-1 (MCP-1) excretion, indicating a temporal and spatial correlation between CD14++CD16+ subset and renal inflammation. Salts 18-22 C-C motif chemokine ligand 2 Homo sapiens 171-176 23295714-8 2013 RESULTS: Sevoflurane suppressed TNF-alpha-induced IL-6, IL-8, and MCP-1 gene expression and the production of IL-6 and IL-8 in SAEC under anoxia/reoxygenation conditions. Sevoflurane 9-20 C-C motif chemokine ligand 2 Homo sapiens 66-71 23146110-9 2013 KEY RESULTS: Andrographolide suppressed cigarette smoke-induced increases in lavage fluid cell counts; levels of IL-1beta, MCP-1, IP-10 and KC; and levels of oxidative biomarkers 8-isoprostane, 8-OHdG and 3-nitrotyrosine in a dose-dependent manner. andrographolide 13-28 C-C motif chemokine ligand 2 Homo sapiens 123-128 23159435-4 2013 RESULTS: Simvastatin, but not placebo, reduced monocyte release of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta and monocyte chemoattractant protein-1, as well decreased plasma levels of C-reactive protein. Simvastatin 9-20 C-C motif chemokine ligand 2 Homo sapiens 133-167 23199701-10 2013 In the metabolic syndrome group, selenium negatively correlated with monocytes chemoattractant protein (MCP)-1 (r=-0.429, P<0.05). Selenium 33-41 C-C motif chemokine ligand 2 Homo sapiens 69-110 23271056-4 2013 Preincubation of primary human SMCs with rHDLs containing apolipoprotein (apo)A-I and phosphatidylcholine (20 muM, final apoA-I concentration), before stimulation with TNF-alpha, inhibited CCL2 (54%), CCL5 (38%), and CX3CL1 (33%) protein levels. Phosphatidylcholines 86-105 C-C motif chemokine ligand 2 Homo sapiens 189-193 23423338-7 2013 MCP-1, a key regulator of monocyte transmigration, showed long-term elevation in busulfan-conditioned brain, whereas irradiated brains showed long-term elevation of the proinflammatory chemokine interleukin 1alpha (IL-1alpha), with increased in situ proliferation of resident microglia, and significant increases in the relative number of amoeboid activated microglia in the brain. Busulfan 81-89 C-C motif chemokine ligand 2 Homo sapiens 0-5 23408783-10 2013 The levels of CRP and MCP-1 were reduced in patients in the RSG, BEZ and combination groups. Rosiglitazone 60-63 C-C motif chemokine ligand 2 Homo sapiens 22-27 23012315-4 2013 In the presence of LPS, vitamin D caused dose-dependent decreases in the messenger RNA expression of MCP-1, IL-1beta, IL-13, TNF-alpha, TLR-4, and TLR-5, the contractile-associated proteins connexin 43, the oxytocin receptor, and the prostaglandin receptor but caused increases in IL-10 and TLR-10 in UtSM cells. Vitamin D 24-33 C-C motif chemokine ligand 2 Homo sapiens 101-106 23012315-6 2013 Vitamin D also attenuated IL-1beta-induced MCP-1, IL-6, connexin 43, cyclooxygenase (COX)-2, and prostaglandin receptor expression. Vitamin D 0-9 C-C motif chemokine ligand 2 Homo sapiens 43-48 23012315-7 2013 Western analysis showed that vitamin D decreased MCP-1, TLR-4, and connexin 43 in the presence of LPS and decreased connexin 43 in the presence of IL-1beta. Vitamin D 29-38 C-C motif chemokine ligand 2 Homo sapiens 49-54 23376721-3 2013 The aim of this study is to evaluate the effect of simvastatin on the ox-LDL-induced ER stress and expression and secretion of TNF-alpha and MCP-1 in 3T3-L1 adipocytes. Simvastatin 51-62 C-C motif chemokine ligand 2 Homo sapiens 141-146 23376721-11 2013 Simvastatin could inhibit ox-LDL-induced ER stress and reduce the expression of TNF-alpha and MCP-1 at mRNA and protien level in dose dependent manner. Simvastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 94-99 22937747-8 2013 Dietary Se significantly decreased renal lipid oxidation, phospho-P65, TNFalpha gene expression, MCP-1 and Cl-Tyr/Tyr, improved NO bioavailability in aorta but not in the renal microvasculature, and inhibited proteinuria. Selenium 8-10 C-C motif chemokine ligand 2 Homo sapiens 97-102 23092829-7 2013 Only MCP-1 production was significantly induced by 7beta-hydroxycholesterol, as well as by cholesterol and oxysterol mixture. cholest-5-en-3 beta,7 alpha-diol 51-75 C-C motif chemokine ligand 2 Homo sapiens 5-10 23092829-7 2013 Only MCP-1 production was significantly induced by 7beta-hydroxycholesterol, as well as by cholesterol and oxysterol mixture. Cholesterol 64-75 C-C motif chemokine ligand 2 Homo sapiens 5-10 23092829-7 2013 Only MCP-1 production was significantly induced by 7beta-hydroxycholesterol, as well as by cholesterol and oxysterol mixture. Oxysterols 107-116 C-C motif chemokine ligand 2 Homo sapiens 5-10 23434371-2 2013 However, here we show that Fas/CD95-induced apoptosis is associated with the production of an array of cytokines and chemokines, including IL-6, IL-8, CXCL1, MCP-1, and GMCSF. ammonium ferrous sulfate 27-30 C-C motif chemokine ligand 2 Homo sapiens 158-163 23434371-3 2013 Fas-induced production of MCP-1 and IL-8 promoted chemotaxis of phagocytes toward apoptotic cells, suggesting that these factors serve as "find-me" signals in this context. ammonium ferrous sulfate 0-3 C-C motif chemokine ligand 2 Homo sapiens 26-31 23397947-0 2013 Nicotinamide downregulates gene expression of interleukin-6, interleukin-10, monocyte chemoattractant protein-1, and tumour necrosis factor-alpha gene expression in HaCaT keratinocytes after ultraviolet B irradiation. Niacinamide 0-12 C-C motif chemokine ligand 2 Homo sapiens 77-111 23397947-3 2013 In this study we investigated whether nicotinamide (NCT), the amide form of vitamin B3, might have a protective function in reducing the expression of interleukin (IL)-1beta, IL-6, IL-8, IL-10, monocyte chemoattractant protein (MCP)-1 and tumour necrosis factor (TNF)-alpha in UV-irradiated keratinocytes. Niacinamide 38-50 C-C motif chemokine ligand 2 Homo sapiens 194-234 23397947-3 2013 In this study we investigated whether nicotinamide (NCT), the amide form of vitamin B3, might have a protective function in reducing the expression of interleukin (IL)-1beta, IL-6, IL-8, IL-10, monocyte chemoattractant protein (MCP)-1 and tumour necrosis factor (TNF)-alpha in UV-irradiated keratinocytes. Amides 45-50 C-C motif chemokine ligand 2 Homo sapiens 194-234 23361158-6 2013 An in vitro experiment was performed to investigate the effect of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) treatment on MCP-1 secretion in THP-1 monocytes activated with lipopolysaccharide (LPS) and Pseudomonas aeruginosa. 1,25-dihydroxyvitamin d3 (1,25(oh)2d3 66-103 C-C motif chemokine ligand 2 Homo sapiens 118-123 23361158-7 2013 RESULTS: By 12 weeks, serum MCP-1 decreased in the cholecalciferol group (66.2+-2.5 to 60.8+-2.6 pg/ml, group-by-time interaction P=0.02) but was not different from baseline at 1 year. Cholecalciferol 51-66 C-C motif chemokine ligand 2 Homo sapiens 28-33 23361158-9 2013 In vitro, LPS- and Pseudomonas-activated monocytes treated with 1,25(OH)2D3 had significantly less MCP-1 secretion compared with untreated cells. Calcitriol 64-75 C-C motif chemokine ligand 2 Homo sapiens 99-104 23361158-10 2013 CONCLUSIONS: High-dose cholecalciferol decreased serum MCP-1 concentrations by 12 weeks in patients with early CKD, although the decrease was not maintained for the remainder of the year. Cholecalciferol 23-38 C-C motif chemokine ligand 2 Homo sapiens 55-60 23361158-11 2013 In vitro results confirm an MCP-1-lowering effect of vitamin D. Vitamin D 53-62 C-C motif chemokine ligand 2 Homo sapiens 28-33 23361158-12 2013 Future studies should determine if vitamin D-mediated reductions in MCP-1 concentrations reflect improved clinical outcomes. Vitamin D 35-44 C-C motif chemokine ligand 2 Homo sapiens 68-73 23408783-11 2013 In addition, RSG, BEZ and the combination of RSG and BEZ also inhibited MCP-1 secretion. Rosiglitazone 13-16 C-C motif chemokine ligand 2 Homo sapiens 72-77 23408783-11 2013 In addition, RSG, BEZ and the combination of RSG and BEZ also inhibited MCP-1 secretion. Bezafibrate 18-21 C-C motif chemokine ligand 2 Homo sapiens 72-77 23408783-11 2013 In addition, RSG, BEZ and the combination of RSG and BEZ also inhibited MCP-1 secretion. Rosiglitazone 45-48 C-C motif chemokine ligand 2 Homo sapiens 72-77 23408783-11 2013 In addition, RSG, BEZ and the combination of RSG and BEZ also inhibited MCP-1 secretion. Bezafibrate 53-56 C-C motif chemokine ligand 2 Homo sapiens 72-77 22508334-0 2013 1,25-Dihydroxyvitamin D3 inhibits the cytokine-induced secretion of MCP-1 and reduces monocyte recruitment by human preadipocytes. Calcitriol 0-24 C-C motif chemokine ligand 2 Homo sapiens 68-73 22508334-10 2013 Pretreatment with 1,25(OH)2D3 (10 nM and 100 nM) significantly decreased the stimulatory effects of MC medium, TNFalpha and IL-1beta on MCP-1 expression and protein release, although the effect on stimulated release of IL-6 was less potent. Calcitriol 18-29 C-C motif chemokine ligand 2 Homo sapiens 136-141 22508334-10 2013 Pretreatment with 1,25(OH)2D3 (10 nM and 100 nM) significantly decreased the stimulatory effects of MC medium, TNFalpha and IL-1beta on MCP-1 expression and protein release, although the effect on stimulated release of IL-6 was less potent. mc medium 100-109 C-C motif chemokine ligand 2 Homo sapiens 136-141 22508334-11 2013 CONCLUSIONS: These results demonstrate that 1,25(OH)2D3 decreases the production of MCP-1 and other proinflammatory mediators by preadipocytes and reduces monocyte migration. Calcitriol 44-55 C-C motif chemokine ligand 2 Homo sapiens 84-89 23529237-7 2013 Pretreatment with high glucose significantly promoted LPS-induced NF-kappaB nuclear translocation (P<0.01) and the mRNA expression and secretion of MCP-1 and IL-6. Glucose 23-30 C-C motif chemokine ligand 2 Homo sapiens 151-156 23525727-9 2013 In KYSE220 cells, pretreatment of MG-132 significantly abrogated upregulation of p65 and APE-1 levels induced by MCP-1, and treatment with 10 and 20 nM p65 siRNA significantly inhibited APE-1 mRNA expression. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 34-40 C-C motif chemokine ligand 2 Homo sapiens 113-118 23529237-6 2013 High glucose promoted NF-kappaB nuclear translocation and significantly enhanced the expression and secretion of both MCP-1 and IL-6 (P<0.01). Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 118-123 23220557-7 2013 The expression levels of 19 genes were statistically significantly correlated with the severity of AC degeneration and changes of SB structure; these included: ADAMTS1, ASPN, BMP6, BMPER, CCL2, CCL8, COL5A1, COL6A3, COL7A1, COL16A1, FRZB, GDF10, MMP3, OGN, OMD, POSTN, PTGES, TNFSF11 and WNT1. Antimony 130-132 C-C motif chemokine ligand 2 Homo sapiens 188-192 23439564-3 2013 PHF, DP and GA could significantly suppress the expression of allergic inflammatory cytokine IL-33-upregulated intercellular adhesion molecule (ICAM)-1, and the release of chemokines CCL2, CCL5, CXCL8 and inflammatory cytokine IL-6 from KU812 cells (all p < 0.05). phf 0-3 C-C motif chemokine ligand 2 Homo sapiens 183-187 23333790-10 2013 NQ up-regulated Il-8, Tnf, and Mcp-1 genes, while AQ induced the expression of Rantes gene. nq 0-2 C-C motif chemokine ligand 2 Homo sapiens 31-36 23192155-0 2013 Increased urinary CCL2: Cr ratio at 6 months is associated with late renal allograft loss. Chromium 24-26 C-C motif chemokine ligand 2 Homo sapiens 18-22 23192155-3 2013 We have previously demonstrated in a multicenter cohort that urinary CCL2 at 6 months is an independent predictor for the development of IFTA at 24 months. ifta 137-141 C-C motif chemokine ligand 2 Homo sapiens 69-73 23192155-7 2013 RESULTS: Urine CCL2: Cr at 6 months was significantly associated with death-censored graft loss (HR, 2.42; 95% CI, 1.54-3.82, P<0.0001). Chromium 21-23 C-C motif chemokine ligand 2 Homo sapiens 15-19 23192155-8 2013 On multivariate analysis, urinary CCL2: Cr at 6 months remained an independent predictor of death-censored graft loss (HR, 2.20; 95% CI, 1.18-4.10, P=0.01) after adjustment for pretransplant/de novo donor-specific antibody and delayed graft function. Chromium 40-42 C-C motif chemokine ligand 2 Homo sapiens 34-38 23161207-9 2013 In group 1 patients, urinary MCP-1/CCL2 levels were negatively correlated to serum albumin levels and positively correlated to the levels of total cholesterol and triglycerides. Cholesterol 147-158 C-C motif chemokine ligand 2 Homo sapiens 29-34 23161207-9 2013 In group 1 patients, urinary MCP-1/CCL2 levels were negatively correlated to serum albumin levels and positively correlated to the levels of total cholesterol and triglycerides. Cholesterol 147-158 C-C motif chemokine ligand 2 Homo sapiens 35-39 23161207-9 2013 In group 1 patients, urinary MCP-1/CCL2 levels were negatively correlated to serum albumin levels and positively correlated to the levels of total cholesterol and triglycerides. Triglycerides 163-176 C-C motif chemokine ligand 2 Homo sapiens 29-34 23161207-9 2013 In group 1 patients, urinary MCP-1/CCL2 levels were negatively correlated to serum albumin levels and positively correlated to the levels of total cholesterol and triglycerides. Triglycerides 163-176 C-C motif chemokine ligand 2 Homo sapiens 35-39 23439564-3 2013 PHF, DP and GA could significantly suppress the expression of allergic inflammatory cytokine IL-33-upregulated intercellular adhesion molecule (ICAM)-1, and the release of chemokines CCL2, CCL5, CXCL8 and inflammatory cytokine IL-6 from KU812 cells (all p < 0.05). dp 5-7 C-C motif chemokine ligand 2 Homo sapiens 183-187 23439564-3 2013 PHF, DP and GA could significantly suppress the expression of allergic inflammatory cytokine IL-33-upregulated intercellular adhesion molecule (ICAM)-1, and the release of chemokines CCL2, CCL5, CXCL8 and inflammatory cytokine IL-6 from KU812 cells (all p < 0.05). Gallic Acid 12-14 C-C motif chemokine ligand 2 Homo sapiens 183-187 23238646-9 2013 Regarding inflammation, no TNFalpha was produced, and lidocaine decreased the levels of IL-6 and MCP-1 in a dose-dependent manner. Lidocaine 54-63 C-C motif chemokine ligand 2 Homo sapiens 97-102 23183267-3 2013 Recently, we showed that the N-terminus of CCL2 is modified to a pyroglutamate (pE)-residue by both glutaminyl cyclases (QC (QPCT)) and its isoenzyme (isoQC (QPCTL)). Pyrrolidonecarboxylic Acid 65-78 C-C motif chemokine ligand 2 Homo sapiens 43-47 23183267-3 2013 Recently, we showed that the N-terminus of CCL2 is modified to a pyroglutamate (pE)-residue by both glutaminyl cyclases (QC (QPCT)) and its isoenzyme (isoQC (QPCTL)). Pyrrolidonecarboxylic Acid 80-82 C-C motif chemokine ligand 2 Homo sapiens 43-47 23089279-7 2013 Treatment with PGF2alpha increased mRNA for AP-1-responsive genes, CCL2 at 0.5 h (202%) and CCL2 and SERPINE1 at 10 h (719% and 1,515%), only in day-17 CL. Dinoprost 15-24 C-C motif chemokine ligand 2 Homo sapiens 67-71 23089279-7 2013 Treatment with PGF2alpha increased mRNA for AP-1-responsive genes, CCL2 at 0.5 h (202%) and CCL2 and SERPINE1 at 10 h (719% and 1,515%), only in day-17 CL. Dinoprost 15-24 C-C motif chemokine ligand 2 Homo sapiens 92-96 23291378-0 2013 Genistein inhibits ox-LDL-induced VCAM-1, ICAM-1 and MCP-1 expression of HUVECs through heme oxygenase-1. Genistein 0-9 C-C motif chemokine ligand 2 Homo sapiens 53-58 23245988-11 2013 Both inhibition of PI3kinase (with wortmannin) and NFkappaB (with BAY11-7085) prevented ASP stimulation of MCP-1 and KC secretion in adipocytes. BAY 11-7085 66-76 C-C motif chemokine ligand 2 Homo sapiens 107-112 23268743-7 2013 In the RAW 264.7 macrophage-derived conditioned medium (RAW-CM)-induced 3T3-L1 adipocyte and 3T3-CM-induced RAW 264.7 macrophage models, pterostilbene significantly decreased IL-6 and TNF-alpha secretion and proinflammatory mRNA expression (COX-2, iNOS, IL-6, TNF-alpha, PAI-1, CRP, MCP-1, resistin, and leptin). pterostilbene 137-150 C-C motif chemokine ligand 2 Homo sapiens 283-288 23291378-7 2013 RESULTS: Pretreatment with genistein markedly reduced ox-LDL-induced MCP-1, VCAM-1 and ICAM-1 secretion and mRNA transcription, which was further decreased by the inducer of HO and reversed by the inhibitor of HO; additionally, the effects were accompanied with upregulating HO-1 mRNA and protein expression and markedly abolished with Nrf2 siRNA. Genistein 27-36 C-C motif chemokine ligand 2 Homo sapiens 69-74 23319318-0 2013 Mycophenolic acid regulates spleen tyrosine kinase to repress tumour necrosis factor-alpha-induced monocyte chemotatic protein-1 production in cultured human aortic endothelial cells. Mycophenolic Acid 0-17 C-C motif chemokine ligand 2 Homo sapiens 99-128 23607100-10 2013 GW501516 also significantly attenuated TNF-mediated expression of MCP-1. GW 501516 0-8 C-C motif chemokine ligand 2 Homo sapiens 66-71 23319318-10 2013 TNF-alpha-induced MCP-1 mRNA expression was inhibited by N-acetylcysteine (NAC), Syk inhibitor, Syk-siRNA and MPA. Acetylcysteine 75-78 C-C motif chemokine ligand 2 Homo sapiens 18-23 23319318-18 2013 MPA exerts anti-inflammatory effect by inhibiting MCP-1 expression via suppression of ROS and Syk. Reactive Oxygen Species 86-89 C-C motif chemokine ligand 2 Homo sapiens 50-55 23319318-10 2013 TNF-alpha-induced MCP-1 mRNA expression was inhibited by N-acetylcysteine (NAC), Syk inhibitor, Syk-siRNA and MPA. Acetylcysteine 57-73 C-C motif chemokine ligand 2 Homo sapiens 18-23 23883876-1 2013 BACKGROUND: Linoleic acid (LA) promotes monocyte chemotaxis and cell adhesion molecules such as MCP-1 and VCAM-1, which contribute to atherosclerogenesis. Linoleic Acid 12-25 C-C motif chemokine ligand 2 Homo sapiens 96-101 23431246-7 2013 HE3286 HbA1c decrease correlated with weight loss and inversely with baseline monocyte chemoattractant protein-1 (MCP-1) in metformin-treated diabetics. Metformin 124-133 C-C motif chemokine ligand 2 Homo sapiens 78-112 23037589-0 2013 Activation of aryl hydrocarbon receptor mediates indoxyl sulfate-induced monocyte chemoattractant protein-1 expression in human umbilical vein endothelial cells. Indican 49-64 C-C motif chemokine ligand 2 Homo sapiens 73-107 23037589-8 2013 Taken together, these results suggest that IS activates AhR as an endogenous agonist and induces MCP-1 expression through reactive oxygen species production in HUVECs. Reactive Oxygen Species 122-145 C-C motif chemokine ligand 2 Homo sapiens 97-102 23043158-7 2013 Fenofibrate also attenuated overexpression of intercellular adhesion molecule-1, monocyte chemoattractant protein-1, and vascular endothelial growth factor (VEGF) and blocked activation of hypoxia-inducible factor-1 and nuclear factor-kappaB in the retinas of OIR and diabetic models. Fenofibrate 0-11 C-C motif chemokine ligand 2 Homo sapiens 81-115 24024768-9 2013 Only TRP significantly decreased serum levels of apolipoprotein B (apoB; -6%), interleukin-8 (IL-8; -11%) and monocyte chemotactic protein-1 (MCP-1; -19%). Tryptophan 5-8 C-C motif chemokine ligand 2 Homo sapiens 110-140 24024768-9 2013 Only TRP significantly decreased serum levels of apolipoprotein B (apoB; -6%), interleukin-8 (IL-8; -11%) and monocyte chemotactic protein-1 (MCP-1; -19%). Tryptophan 5-8 C-C motif chemokine ligand 2 Homo sapiens 142-147 23983782-6 2013 Results showed that the hyperglycemia-induced GAG alterations in the cell surface perlecan as well as in the ECM indeed upregulated the expressions of IL-6, IL-8, and MCP-1 and the activities of MMP-2 and MMP-9 and downregulated the expressions of TIMP-2. Glycosaminoglycans 46-49 C-C motif chemokine ligand 2 Homo sapiens 167-172 23470566-6 2013 RESULTS: We found increased production of TNF-alpha, MCP-1, IL-6, and free glycerol, FFAs in the co-culture medium, and butyrate significantly reduced them. Butyrates 120-128 C-C motif chemokine ligand 2 Homo sapiens 53-58 22990668-8 2013 RESULTS: Treatment of RA FLS with GW3965 induced dose-dependent reductions in mRNA expression of pro-inflammatory mediators (IL-1beta, IL-6, MMP-9, CCL-2, CCL-7, and COX-2). GW 3965 34-40 C-C motif chemokine ligand 2 Homo sapiens 148-153 23431246-7 2013 HE3286 HbA1c decrease correlated with weight loss and inversely with baseline monocyte chemoattractant protein-1 (MCP-1) in metformin-treated diabetics. Metformin 124-133 C-C motif chemokine ligand 2 Homo sapiens 114-119 23074218-8 2012 1,25(OH)(2)D(3) supplementation also inhibited monocyte chemoattractant protein-1 and stimulated adiponectin secretion in HG-treated adipocytes, and this positive effect was prevented in propargylglycine-treated or CSE-knockdown adipocytes. propargylglycine 187-203 C-C motif chemokine ligand 2 Homo sapiens 47-81 22841520-5 2013 RESULTS: Compared to placebo, metformin reduced monocyte release of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, monocyte chemoattractant protein-1 and interleukin-8, as well as decreased plasma C-reactive protein levels, which were accompanied by an improvement in insulin sensitivity. Metformin 30-39 C-C motif chemokine ligand 2 Homo sapiens 131-165 23358371-6 2013 Recently, the association of serum selenium with adipocytokines, such as TNF-alpha, VCAM-1, leptin, FABP-4, and MCP-1, has been observed. Selenium 35-43 C-C motif chemokine ligand 2 Homo sapiens 112-117 23560031-8 2013 MCP-1 correlated significantly with SRT, dIS/OS, and dELM. Osmium 45-47 C-C motif chemokine ligand 2 Homo sapiens 0-5 24399727-6 2013 RESULTS: Metformin treatment reduced plasma C-reactive protein levels and monocyte release of tumor necrosis factor-alpha and interleukin-6, as well as tended to reduce monocyte release of interleukin-1beta and monocyte chemoattractant protein-1, which was accompanied by an improvement in insulin sensitivity. Metformin 9-18 C-C motif chemokine ligand 2 Homo sapiens 211-245 23555755-5 2013 Notably, phosphatidylcholine-specific phospholipase C (PC-PLC), previously reported to be required for NF-kB-mediated CCL2 production induced by gp120 in macrophages, drives both ERK1/2 activation and PI-PLC beta1 nuclear localization induced by gp120. Phosphatidylcholines 9-28 C-C motif chemokine ligand 2 Homo sapiens 118-122 22953728-5 2013 The expression levels of the prostaglandin-dependent Tnfaip6 and Ccl2 genes were also altered in B10.BR(Y(del)) cumulus cells in a manner indicating increased prostaglandin signalling. Prostaglandins 29-42 C-C motif chemokine ligand 2 Homo sapiens 65-69 22953728-5 2013 The expression levels of the prostaglandin-dependent Tnfaip6 and Ccl2 genes were also altered in B10.BR(Y(del)) cumulus cells in a manner indicating increased prostaglandin signalling. Prostaglandins 159-172 C-C motif chemokine ligand 2 Homo sapiens 65-69 22985912-5 2013 The secretion of proinflammatory products was strongly stimulated by sequential incubation of EC with iodixanol and TNFalpha (p<0.00001 for all tested molecules, namely TNFalpha, IL-8, sVCAM-1, MCP-1, and IL-6). iodixanol 102-111 C-C motif chemokine ligand 2 Homo sapiens 197-202 22985912-6 2013 N-acetylcysteine prevented morphologic and oxidative derangements, and significantly reduced proinflammatory product secretion (P range<0.0001 to<0.00001 for TNFalpha, VCAM-1, MCP-1, and IL-6); rosuvastatin inhibited morphology and oxidative modifications only. Acetylcysteine 0-16 C-C motif chemokine ligand 2 Homo sapiens 182-187 23887394-12 2013 15d-PGJ2 downregulated LPS-induced IL-8 and MCP-1 production. 15-deoxyprostaglandin J2 0-8 C-C motif chemokine ligand 2 Homo sapiens 44-49 23259689-7 2012 However, all the PUFA tested: DHA, EPA and to a lesser extent OA down-regulated TNF-alpha, IL-6 and MCP-1 secretion in human adipose tissue and adipocytes cultures. dehydroacetic acid 30-33 C-C motif chemokine ligand 2 Homo sapiens 100-105 23259744-10 2012 In M10 cells, TMZ promoted NF-kappaB2/p52 generation and nuclear translocation and enhanced the secretion of IL-8 and MCP-1. Temozolomide 14-17 C-C motif chemokine ligand 2 Homo sapiens 118-123 23017229-2 2012 Monocyte chemoattractant protein-1 (MCP-1) is a member of the cysteine-cysteine (CC) chemokine family and is increased in obesity. cysteine-cysteine 62-79 C-C motif chemokine ligand 2 Homo sapiens 0-34 23089469-0 2012 High therapeutic concentration of prazosin up-regulates angiogenic IL6 and CCL2 genes in hepatocellular carcinoma cells. Prazosin 34-42 C-C motif chemokine ligand 2 Homo sapiens 75-79 23089469-4 2012 This study was to investigate the influence of therapeutic concentrations of prazosin (0.01 and 0.1muM) on cell proliferation and differential expressions of CCL2, CCL20, CXCL6, CXCL10, IL8 and IL6 genes related to inflammation and/or oxidative stress in human HCC cell lines. Prazosin 77-85 C-C motif chemokine ligand 2 Homo sapiens 158-162 23089469-10 2012 However, 0.1muM prazosin caused remarkable up-regulation of IL6 gene and slightly up-regulation of CCL2 gene in cell line B. Prazosin 16-24 C-C motif chemokine ligand 2 Homo sapiens 99-103 23089469-11 2012 In conclusion, high therapeutic concentration of prazosin can up-regulate angiogenic IL6 and CCL2 genes in human HCC cells susceptible to amphotericin B-induced oxidative stress. Prazosin 49-57 C-C motif chemokine ligand 2 Homo sapiens 93-97 23089469-11 2012 In conclusion, high therapeutic concentration of prazosin can up-regulate angiogenic IL6 and CCL2 genes in human HCC cells susceptible to amphotericin B-induced oxidative stress. Amphotericin B 138-152 C-C motif chemokine ligand 2 Homo sapiens 93-97 23017229-2 2012 Monocyte chemoattractant protein-1 (MCP-1) is a member of the cysteine-cysteine (CC) chemokine family and is increased in obesity. cysteine-cysteine 62-79 C-C motif chemokine ligand 2 Homo sapiens 36-41 22579840-1 2012 We investigated the effect of caffeoylserotonin (CaS) on THP-1 monocyte migration and adhesion to fibronectin in response to MCP-1. N-caffeoylserotonin 30-47 C-C motif chemokine ligand 2 Homo sapiens 125-130 22579840-1 2012 We investigated the effect of caffeoylserotonin (CaS) on THP-1 monocyte migration and adhesion to fibronectin in response to MCP-1. cas 49-52 C-C motif chemokine ligand 2 Homo sapiens 125-130 22579840-2 2012 CaS decreased monocyte adhesion and migration induced by MCP-1, together with CCR2 expression and alpha5beta1 integrin, and activated beta1 integrin expression on the cell surface. cas 0-3 C-C motif chemokine ligand 2 Homo sapiens 57-62 22535284-7 2012 Additionally, a higher oxygen tension led to an upregulation of the expression of IL-6, MCP-1, and PPAR-gamma, while ANGPTL4 was downregulated in the hyperoxia group with respect to control. Oxygen 23-29 C-C motif chemokine ligand 2 Homo sapiens 88-93 22475809-6 2012 Moreover, IL-6 and MCP-1 were more significantly reduced by EPA treatment compared to Agt (IL-6>MCP>Agt). Eicosapentaenoic Acid 60-63 C-C motif chemokine ligand 2 Homo sapiens 19-24 22475809-9 2012 Moreover, EPA attenuated tumor necrosis factor-alpha-induced MCP-1 and further reduced its secretion in the presence of an NF-kappaB inhibitor. Eicosapentaenoic Acid 10-13 C-C motif chemokine ligand 2 Homo sapiens 61-66 23150653-11 2012 Plaque suPAR levels correlated with plaque content of lipids and macrophages and with proinflammatory chemokines and cytokines monocyte chemoattractant protein 1, tumor necrosis factor alpha, interleukin 1beta, interleukin 6, platelet-derived growth factor AB/BB, monocyte inflammatory protein 1beta, regulated on activation normal T-cell expressed and secreted, and s-CD40L. supar 7-12 C-C motif chemokine ligand 2 Homo sapiens 127-161 22982961-2 2012 Bindarit is an original indazolic derivative able to inhibit MCPs synthesis and to significantly decrease MCP-1/CCL2 urinary excretion in patients with Lupus Nephritis, in correlation with reduction in albuminuria. bindarit 0-8 C-C motif chemokine ligand 2 Homo sapiens 112-116 22982961-2 2012 Bindarit is an original indazolic derivative able to inhibit MCPs synthesis and to significantly decrease MCP-1/CCL2 urinary excretion in patients with Lupus Nephritis, in correlation with reduction in albuminuria. indazolic 24-33 C-C motif chemokine ligand 2 Homo sapiens 106-111 22982961-2 2012 Bindarit is an original indazolic derivative able to inhibit MCPs synthesis and to significantly decrease MCP-1/CCL2 urinary excretion in patients with Lupus Nephritis, in correlation with reduction in albuminuria. indazolic 24-33 C-C motif chemokine ligand 2 Homo sapiens 112-116 22982961-5 2012 Bindarit (10-300 muM) significantly inhibited MCP-1/CCL2 release in response to both stimuli within 12h. bindarit 0-8 C-C motif chemokine ligand 2 Homo sapiens 46-51 22982961-5 2012 Bindarit (10-300 muM) significantly inhibited MCP-1/CCL2 release in response to both stimuli within 12h. bindarit 0-8 C-C motif chemokine ligand 2 Homo sapiens 52-56 22982961-6 2012 Bindarit also inhibited mRNA MCP-1/CCL2 expression, confirming an effect of the drug at transcriptional level. bindarit 0-8 C-C motif chemokine ligand 2 Homo sapiens 29-34 22982961-6 2012 Bindarit also inhibited mRNA MCP-1/CCL2 expression, confirming an effect of the drug at transcriptional level. bindarit 0-8 C-C motif chemokine ligand 2 Homo sapiens 35-39 22982961-2 2012 Bindarit is an original indazolic derivative able to inhibit MCPs synthesis and to significantly decrease MCP-1/CCL2 urinary excretion in patients with Lupus Nephritis, in correlation with reduction in albuminuria. bindarit 0-8 C-C motif chemokine ligand 2 Homo sapiens 106-111 22514016-5 2012 The mean level of the serum monocyte chemoattractant protein-1 (MCP-1) in the HFD group was significantly higher than that in the HCD and CD groups (P = 0.024; HFD vs. HCD, P = 0.033; HFD vs. CD, P = 0.001). Cadmium 131-133 C-C motif chemokine ligand 2 Homo sapiens 28-62 22514016-5 2012 The mean level of the serum monocyte chemoattractant protein-1 (MCP-1) in the HFD group was significantly higher than that in the HCD and CD groups (P = 0.024; HFD vs. HCD, P = 0.033; HFD vs. CD, P = 0.001). Cadmium 138-140 C-C motif chemokine ligand 2 Homo sapiens 28-62 23010641-8 2012 RESULTS: A marked increase in the expression of MCP-1 was detected 4 weeks after STZ injection, and the expression was consistently upregulated at 3 and 5 months in the rodent DR model. Streptozocin 81-84 C-C motif chemokine ligand 2 Homo sapiens 48-53 22425757-9 2012 Accordingly, (-)-epicatechin inhibited TNFalpha-mediated altered transcription of genes (MCP-1, interleukin-6, TNFalpha, resistin, and protein-tyrosine phosphatase 1B) involved in inflammation and insulin signaling. Catechin 13-28 C-C motif chemokine ligand 2 Homo sapiens 89-94 23181472-8 2012 A differential secretion of CXCL8 and CCL2 was observed upon oligosaccharide co-cultivation with colorectal epithelial Caco-2 cells. Oligosaccharides 61-76 C-C motif chemokine ligand 2 Homo sapiens 38-42 22750393-9 2012 In contrast, beta-carotene increased the expression of CaMKKII, PI3K, PZK1, LKB1, eNOS, PON-1, and reduced the expression of ICAM-1 and MCP-1. beta Carotene 13-26 C-C motif chemokine ligand 2 Homo sapiens 136-141 22895606-0 2012 Tacrolimus (FK506) suppresses TNF-alpha-induced CCL2 (MCP-1) and CXCL10 (IP-10) expression via the inhibition of p38 MAP kinase activation in human colonic myofibroblasts. Tacrolimus 12-17 C-C motif chemokine ligand 2 Homo sapiens 48-52 22895606-0 2012 Tacrolimus (FK506) suppresses TNF-alpha-induced CCL2 (MCP-1) and CXCL10 (IP-10) expression via the inhibition of p38 MAP kinase activation in human colonic myofibroblasts. Tacrolimus 12-17 C-C motif chemokine ligand 2 Homo sapiens 54-59 22895606-5 2012 Tacrolimus (1 microM) suppressed tumor necrosis factor (TNF)-alpha-induced CCL2 and CXCL10 mRNA expression, but did not modulate TNF-alpha-induced interleukin (IL)-6 or CXCL8 mRNA expression. Tacrolimus 0-10 C-C motif chemokine ligand 2 Homo sapiens 75-79 22895606-6 2012 Dose-dependent, inhibitory effects of tacrolimus on CCL2 and CXCL10 expression were observed at the mRNA and protein levels. Tacrolimus 38-48 C-C motif chemokine ligand 2 Homo sapiens 52-56 22895606-7 2012 Significant inhibitory effects of tacrolimus were observed at concentrations as low as 0.5 microM for CCL2 and 0.1 microM for CXCL10, respectively. Tacrolimus 34-44 C-C motif chemokine ligand 2 Homo sapiens 102-106 22895606-10 2012 In conclusion, tacrolimus suppressed CCL2 and CXCL10 expression in human colonic myofibroblasts. Tacrolimus 15-25 C-C motif chemokine ligand 2 Homo sapiens 37-41 22895606-0 2012 Tacrolimus (FK506) suppresses TNF-alpha-induced CCL2 (MCP-1) and CXCL10 (IP-10) expression via the inhibition of p38 MAP kinase activation in human colonic myofibroblasts. Tacrolimus 0-10 C-C motif chemokine ligand 2 Homo sapiens 48-52 22895606-0 2012 Tacrolimus (FK506) suppresses TNF-alpha-induced CCL2 (MCP-1) and CXCL10 (IP-10) expression via the inhibition of p38 MAP kinase activation in human colonic myofibroblasts. Tacrolimus 0-10 C-C motif chemokine ligand 2 Homo sapiens 54-59 22843790-11 2012 Moreover, EGCG diminished OSM-stimulated CCL2 expression at least partially via suppressing Cyr61 induction. epigallocatechin gallate 10-14 C-C motif chemokine ligand 2 Homo sapiens 41-45 23316654-7 2012 In addition, the possibilities that intraocular soluble glucosaminoglycans can inhibit the function of another heparin-binding inflammatory cytokine, CCL2, and suppress the intraocular inflammation, are proposed. glucosaminoglycans 56-74 C-C motif chemokine ligand 2 Homo sapiens 150-154 22915474-6 2012 Here, we demonstrate that melamine can activate mitogen-activated protein kinases, NFkappaB, and reactive oxygen species, which results in the upregulation of interleukin-6, monocyte chemoattractant protein-1, vascular cell adhesion molecule-1, and TGF-beta1 in HK-2 cells. melamine 26-34 C-C motif chemokine ligand 2 Homo sapiens 174-208 22674286-11 2012 Thrombin-mediated CCL2 production was attenuated by the thrombin inhibitor PPACK, the protein kinase Cdelta (PKCdelta) inhibitor rottlerin, the c-Src inhibitor PP2, epidermal growth factor receptor (EGFR) inhibitor AG-1478, MEK inhibitors PD98059 and U0126, or AP-1 inhibitors curcumin and tanshinone IIA. rottlerin 129-138 C-C motif chemokine ligand 2 Homo sapiens 18-22 22609259-7 2012 The concentration of circulating MCP-1 and the urinary MCP-1 to creatinine ratio (UMCR) were higher in the obese group and were correlated with fat mass and HOMA-IR. Creatinine 64-74 C-C motif chemokine ligand 2 Homo sapiens 55-60 22674286-11 2012 Thrombin-mediated CCL2 production was attenuated by the thrombin inhibitor PPACK, the protein kinase Cdelta (PKCdelta) inhibitor rottlerin, the c-Src inhibitor PP2, epidermal growth factor receptor (EGFR) inhibitor AG-1478, MEK inhibitors PD98059 and U0126, or AP-1 inhibitors curcumin and tanshinone IIA. Curcumin 277-285 C-C motif chemokine ligand 2 Homo sapiens 18-22 22674286-11 2012 Thrombin-mediated CCL2 production was attenuated by the thrombin inhibitor PPACK, the protein kinase Cdelta (PKCdelta) inhibitor rottlerin, the c-Src inhibitor PP2, epidermal growth factor receptor (EGFR) inhibitor AG-1478, MEK inhibitors PD98059 and U0126, or AP-1 inhibitors curcumin and tanshinone IIA. tanshinone 290-304 C-C motif chemokine ligand 2 Homo sapiens 18-22 22674286-11 2012 Thrombin-mediated CCL2 production was attenuated by the thrombin inhibitor PPACK, the protein kinase Cdelta (PKCdelta) inhibitor rottlerin, the c-Src inhibitor PP2, epidermal growth factor receptor (EGFR) inhibitor AG-1478, MEK inhibitors PD98059 and U0126, or AP-1 inhibitors curcumin and tanshinone IIA. RTKI cpd 215-222 C-C motif chemokine ligand 2 Homo sapiens 18-22 22674286-11 2012 Thrombin-mediated CCL2 production was attenuated by the thrombin inhibitor PPACK, the protein kinase Cdelta (PKCdelta) inhibitor rottlerin, the c-Src inhibitor PP2, epidermal growth factor receptor (EGFR) inhibitor AG-1478, MEK inhibitors PD98059 and U0126, or AP-1 inhibitors curcumin and tanshinone IIA. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 239-246 C-C motif chemokine ligand 2 Homo sapiens 18-22 22674286-11 2012 Thrombin-mediated CCL2 production was attenuated by the thrombin inhibitor PPACK, the protein kinase Cdelta (PKCdelta) inhibitor rottlerin, the c-Src inhibitor PP2, epidermal growth factor receptor (EGFR) inhibitor AG-1478, MEK inhibitors PD98059 and U0126, or AP-1 inhibitors curcumin and tanshinone IIA. U 0126 251-256 C-C motif chemokine ligand 2 Homo sapiens 18-22 22809665-7 2012 We also found that Nac pre-administration resulted in lower blood levels of the cytokines and chemokines interferon-gamma, interleukin-10, CCL2, CCL4, and CCL5, but only lowered CCL4 in the cerebral cortex and hippocampus. nac 19-22 C-C motif chemokine ligand 2 Homo sapiens 139-143 22800603-5 2012 In HCs, vitamin D(3) significantly suppressed the MCP-1 mRNA expression of CFA stimulated cells (p=0.0027), while no such effect was observed in PTB patients. Vitamin D 8-17 C-C motif chemokine ligand 2 Homo sapiens 50-55 22658637-12 2012 CONCLUSIONS: Our findings suggested that simvastatin counteracted the stimulatory effect of TNF-alpha on secretion and expression of MCP-1, PAI-1 and adiponectin, implying a potential anti-atherogenic effect during the inflammatory process; these pleitropic effects were more pronounced with HMG-CoA reductase inhibitor. Simvastatin 41-52 C-C motif chemokine ligand 2 Homo sapiens 133-138 22762377-3 2012 While poly(I:C) induced IL-8 gene expression was solely inhibited by the NF-kappaB inhibitor III, MCP-1 gene induction was also blocked by PKA, p38 MAPK and JAK-STAT inhibitors. Poly I-C 6-14 C-C motif chemokine ligand 2 Homo sapiens 98-103 22762377-4 2012 Moreover, Brefeldin A, an inhibitor of the anterograde transport, suppressed MCP-1 but not IL-8 gene expression, indicating that poly(I:C)-induced cytokines are involved in the chemokine gene expression. Brefeldin A 10-21 C-C motif chemokine ligand 2 Homo sapiens 77-82 22762377-6 2012 These data are indicative for distinct signalling pathways in the poly(I:C)-induced gene expression of IL-8 and MCP-1 in HaCaT keratinocytes. Poly I-C 66-75 C-C motif chemokine ligand 2 Homo sapiens 112-117 22743636-5 2012 At 3 days after TNFalpha stimulation, 30 muM telmisartan or 20 mM NAC administered before and during TNFalpha stimulation prevented the enhancement of LPC content in LDL and monocyte chemoattractant protein-1 mRNA by LDL incubation with TNFalpha-stimulated HUVEC. Acetylcysteine 66-69 C-C motif chemokine ligand 2 Homo sapiens 174-208 22787116-10 2012 MG262 concentration-dependently inhibited basal and transforming growth factor-beta-induced collagen mRNA expression and interleukin (IL)-1beta-induced production of IL-6, IL-8, monocyte chemoattractant protein-1, regulated on activation normal T cell expressed and secreted, and granulocyte/macrophage colony-stimulating factor in both fibroblast types. MG 262 0-5 C-C motif chemokine ligand 2 Homo sapiens 178-212 22980179-8 2012 CONCLUSIONS: Analyses of cytokines and the chemokine CCL-2/MCP-1 demonstrated the benefits of calcium hydroxide as a root canal dressing because it impedes the increase of all mediators during the experimental time. Calcium Hydroxide 94-111 C-C motif chemokine ligand 2 Homo sapiens 59-64 22322985-5 2012 The results showed that RIN markedly reduced the production of nitric oxide (NO), prostaglandins E(2) (PGE(2) ), monocyte chemoattractant protein (MCP-1), tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in LPS-activated microglia. rhyncophylline 24-27 C-C motif chemokine ligand 2 Homo sapiens 147-152 23302384-0 2012 [Effect of berberine hydrochloride on the secretion of monocyte chemoattractant protein-1 from human periodontal ligament cells in vitro]. berberine chloride 11-34 C-C motif chemokine ligand 2 Homo sapiens 55-89 22690903-5 2012 Only lipopolysaccharide (LPS), poly(I:C), Pam3CSK4 and MALP-2 could induce the production of IL-6, IL-8 and MCP-1 by adipocytes. Poly I 31-37 C-C motif chemokine ligand 2 Homo sapiens 108-113 22690903-5 2012 Only lipopolysaccharide (LPS), poly(I:C), Pam3CSK4 and MALP-2 could induce the production of IL-6, IL-8 and MCP-1 by adipocytes. Carbon 38-39 C-C motif chemokine ligand 2 Homo sapiens 108-113 23302384-9 2012 CONCLUSIONS: The inhibitory effect of berberine hydrochloride on the activities of MCP-1 from PDLC was more significant when PDLC were stimulated with LPS and in a concentration-dependent manner. berberine chloride 38-61 C-C motif chemokine ligand 2 Homo sapiens 83-88 22449852-4 2012 The CaSR activation by the calcimimatic cinacalcet (5muM) in adipose tissue and in vitro cultured LS14 adipose cells elicited an elevation in the expression of the proinflammatory cytokines IL6, IL1beta, TNFalpha, and the chemoattractant CCL2. Cinacalcet 40-50 C-C motif chemokine ligand 2 Homo sapiens 238-242 26894024-10 2012 In cultured VSMCs, leptin increased MCP-1 production in a dose-dependent manner, and this stimulating effect of leptin on MCP-1 expression was reversed by the MAPK (MEK) inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 180-187 C-C motif chemokine ligand 2 Homo sapiens 36-41 22433003-11 2012 Licofelone reduced interleukin-18-induced phosphorylation of p38 mitogen-activated protein kinase and suppressed monocyte chemotactic protein-1 and interferon-gamma synthesis. licofelone 0-10 C-C motif chemokine ligand 2 Homo sapiens 113-143 22897577-6 2012 We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs. Adenosine Triphosphate 93-96 C-C motif chemokine ligand 2 Homo sapiens 261-265 22897577-6 2012 We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs. Adenosine Triphosphate 93-96 C-C motif chemokine ligand 2 Homo sapiens 267-297 22897577-6 2012 We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs. adenosine 5'-O-(3-thiotriphosphate) 102-138 C-C motif chemokine ligand 2 Homo sapiens 261-265 22897577-6 2012 We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs. adenosine 5'-O-(3-thiotriphosphate) 102-138 C-C motif chemokine ligand 2 Homo sapiens 267-297 22897577-6 2012 We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs. adenosine 5'-O-(3-thiotriphosphate) 140-149 C-C motif chemokine ligand 2 Homo sapiens 261-265 22897577-6 2012 We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs. adenosine 5'-O-(3-thiotriphosphate) 140-149 C-C motif chemokine ligand 2 Homo sapiens 267-297 22897577-6 2012 We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs. Adenosine Triphosphate 140-143 C-C motif chemokine ligand 2 Homo sapiens 261-265 22897577-6 2012 We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs. Adenosine Triphosphate 140-143 C-C motif chemokine ligand 2 Homo sapiens 267-297 22897577-8 2012 We have now demonstrated that AFC dose-dependently inhibits ATP-, ATPgammaS- and TNFalpha-induced production of CXCL1, CXCL8 and CCL2 by a human dermal microvascular EC line (HMEC-1) in vitro under conditions that do not affect cell viability. Adenosine Triphosphate 60-63 C-C motif chemokine ligand 2 Homo sapiens 129-133 22897577-8 2012 We have now demonstrated that AFC dose-dependently inhibits ATP-, ATPgammaS- and TNFalpha-induced production of CXCL1, CXCL8 and CCL2 by a human dermal microvascular EC line (HMEC-1) in vitro under conditions that do not affect cell viability. adenosine 5'-O-(3-thiotriphosphate) 66-75 C-C motif chemokine ligand 2 Homo sapiens 129-133 22487967-5 2012 Pretreatment of slices with 15d-PGJ2 markedly reduced Tat-induced monocyte chemoattractant protein-1 (MCP-1/CCL2) production. 15-deoxy-delta(12,14)-prostaglandin J2 28-36 C-C motif chemokine ligand 2 Homo sapiens 66-100 22487967-5 2012 Pretreatment of slices with 15d-PGJ2 markedly reduced Tat-induced monocyte chemoattractant protein-1 (MCP-1/CCL2) production. 15-deoxy-delta(12,14)-prostaglandin J2 28-36 C-C motif chemokine ligand 2 Homo sapiens 102-107 22487967-5 2012 Pretreatment of slices with 15d-PGJ2 markedly reduced Tat-induced monocyte chemoattractant protein-1 (MCP-1/CCL2) production. 15-deoxy-delta(12,14)-prostaglandin J2 28-36 C-C motif chemokine ligand 2 Homo sapiens 108-112 22487967-9 2012 Conversely, 15d-PGJ2 suppressed Tat-induced ERK1/2 activation, decreasing MCP-1 production upon Tat stimulation. 15-deoxy-delta(12,14)-prostaglandin J2 12-20 C-C motif chemokine ligand 2 Homo sapiens 74-79 22487967-10 2012 The NADPH oxidase inhibitors DPI and apocynin also abrogated Tat-stimulated ERK1/2 activation, reducing MCP-1 production. 3-aminodiphenyleneiodium 29-32 C-C motif chemokine ligand 2 Homo sapiens 104-109 22487967-10 2012 The NADPH oxidase inhibitors DPI and apocynin also abrogated Tat-stimulated ERK1/2 activation, reducing MCP-1 production. acetovanillone 37-45 C-C motif chemokine ligand 2 Homo sapiens 104-109 22884503-5 2012 The current study demonstrates that mitoxantrone inhibits lipopolysachharide (LPS) induction of NO, TNF-alpha, IL-1beta, and MCP-1 production by primary astrocytes. Mitoxantrone 36-48 C-C motif chemokine ligand 2 Homo sapiens 125-130 22884503-5 2012 The current study demonstrates that mitoxantrone inhibits lipopolysachharide (LPS) induction of NO, TNF-alpha, IL-1beta, and MCP-1 production by primary astrocytes. lipopolysachharide 58-76 C-C motif chemokine ligand 2 Homo sapiens 125-130 22823162-2 2012 In this study, we demonstrate that the Toll-like receptor-2 agonist Pam2Cys, when administered intranasally, triggers a cascade of inflammatory and innate immune signals, acting as an immunostimulant by attracting neutrophils and macrophages and inducing secretion of IL-2, IL-6, IL-10, IFN-gamma, MCP-1 and TNF-alpha. S-(2,3-bis(palmitoyloxy)propyl)cysteine 68-75 C-C motif chemokine ligand 2 Homo sapiens 298-303 22790593-6 2012 HCl upregulated mRNA and protein expression for the acid-sensing transient receptor potential cation channel, subfamily vanilloid member 1 (TRPV1), lyso-PAF AT, IL-8, eotaxin-1, -2, and -3, macrophage inflammatory protein-1alpha, and monocyte chemoattractant protein-1. Hydrochloric Acid 0-3 C-C motif chemokine ligand 2 Homo sapiens 234-268 22897577-6 2012 We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs. Adenosine Triphosphate 66-91 C-C motif chemokine ligand 2 Homo sapiens 261-265 22897577-6 2012 We have previously shown that the sympathetic nerve cotransmitter adenosine-5"-triphosphate (ATP) and adenosine-5"-O-(3-thio) triphosphate (ATPgammaS), an ATP analogue that is resistant to hydrolysis, increase secretion of the chemokines CXCL8 (interleukin-8), CCL2 (monocyte chemotactic protein-1) and CXCL1 (growth-regulated oncogene alpha) by dermal microvascular ECs. Adenosine Triphosphate 66-91 C-C motif chemokine ligand 2 Homo sapiens 267-297 22487967-0 2012 15-deoxy-Delta12,14 -prostaglandin J2 inhibits human immunodeficiency virus-1 tat-induced monocyte chemoattractant protein-1/CCL2 production by blocking the extracellular signal-regulated kinase-1/2 signaling pathway independently of peroxisome proliferator-activated receptor-gamma and heme oxygenase-1 in rat hippocampal slices. 14 -prostaglandin j2 17-37 C-C motif chemokine ligand 2 Homo sapiens 90-124 22487967-0 2012 15-deoxy-Delta12,14 -prostaglandin J2 inhibits human immunodeficiency virus-1 tat-induced monocyte chemoattractant protein-1/CCL2 production by blocking the extracellular signal-regulated kinase-1/2 signaling pathway independently of peroxisome proliferator-activated receptor-gamma and heme oxygenase-1 in rat hippocampal slices. 14 -prostaglandin j2 17-37 C-C motif chemokine ligand 2 Homo sapiens 125-129 26894024-10 2012 In cultured VSMCs, leptin increased MCP-1 production in a dose-dependent manner, and this stimulating effect of leptin on MCP-1 expression was reversed by the MAPK (MEK) inhibitor PD98059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 180-187 C-C motif chemokine ligand 2 Homo sapiens 122-127 22801372-2 2012 We previously demonstrated that dexamethasone (Dex) inhibits MCP-1 mRNA accumulation in smooth muscle cells by decreasing its half-life. Dexamethasone 32-45 C-C motif chemokine ligand 2 Homo sapiens 61-66 22993666-0 2012 Relationship between vitamin D and IL-23, IL-17 and macrophage chemoattractant protein-1 as markers of fibrosis in hepatitis C virus Egyptians. Vitamin D 21-30 C-C motif chemokine ligand 2 Homo sapiens 52-88 22801372-2 2012 We previously demonstrated that dexamethasone (Dex) inhibits MCP-1 mRNA accumulation in smooth muscle cells by decreasing its half-life. Dexamethasone 47-50 C-C motif chemokine ligand 2 Homo sapiens 61-66 22801372-6 2012 YB-1, UK, and GR small interfering RNA (siRNA) substantially inhibited the effect of Dex on MCP-1 mRNA accumulation. Dexamethasone 85-88 C-C motif chemokine ligand 2 Homo sapiens 92-97 22801372-7 2012 In addition, YB-1 antibody blocked the degradation of MCP-1 mRNA by cytoplasmic extracts from the Dex-treated cells. Dexamethasone 98-101 C-C motif chemokine ligand 2 Homo sapiens 54-59 22993666-1 2012 AIM: To assess vitamin D in hepatitis C patients and its relationship to interleukin (IL)-23, IL-17, and macrophage chemoattractant protein-1 (MCP-1). Vitamin D 15-24 C-C motif chemokine ligand 2 Homo sapiens 105-141 22993666-1 2012 AIM: To assess vitamin D in hepatitis C patients and its relationship to interleukin (IL)-23, IL-17, and macrophage chemoattractant protein-1 (MCP-1). Vitamin D 15-24 C-C motif chemokine ligand 2 Homo sapiens 143-148 22993666-20 2012 IL-23, IL-17, and MCP-1 were markedly increased in HCV-infected patients in comparison to controls.A significant negative correlation between vitamin D and IL-17 and -23 and MCP-1 was detected. Vitamin D 142-151 C-C motif chemokine ligand 2 Homo sapiens 174-179 22768975-11 2012 EGCG also inhibited the expression of MCP-1/CCL2, VCAM-1 and ICAM-1. epigallocatechin gallate 0-4 C-C motif chemokine ligand 2 Homo sapiens 38-43 22621785-7 2012 Pre-exposure of adherent human monocytes to sEHI (5 muM) significantly inhibited lipopolysaccharide-induced release of monocyte chemotactic protein-1 (MCP-1) and tumor necrosis factor-alpha and enhanced the EET-to-diol ratio. sehi 44-48 C-C motif chemokine ligand 2 Homo sapiens 119-149 22677362-3 2012 As in humans, cantharidin (12.5 mug/ear) generated macrophage-inflammatory protein (MIP)-2, monocyte chemoattractant protein (MCP)-1, keratinocyte-derived chemokine (KC), interleukin (IL)-6, IL-1beta, and myeloperoxidase (MPO) production, as well as neutrophil accumulation in mouse ear tissue. Cantharidin 14-25 C-C motif chemokine ligand 2 Homo sapiens 92-132 22711276-8 2012 The significantly higher levels of expression of cKIT, monocyte chemoattractant protein-1, interleukin-6, stromal-derived factor-1, platelet-derived growth factor-b, and S100A4 in R-cells were downregulated by valproic acid and suberoylanilide hydroxamic acid treatment. Valproic Acid 210-223 C-C motif chemokine ligand 2 Homo sapiens 55-89 22592163-3 2012 This study focused on the ability of these alkaloids to modulate the gene expression of pro-inflammatory tumour necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein 1 (MCP-1, also known as CCL-2), interleukin (IL)-6, IL-1beta and anti-inflammatory cytokines IL-1 receptor antagonist (IL-1RA) and IL-10. Alkaloids 43-52 C-C motif chemokine ligand 2 Homo sapiens 147-181 22592163-3 2012 This study focused on the ability of these alkaloids to modulate the gene expression of pro-inflammatory tumour necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein 1 (MCP-1, also known as CCL-2), interleukin (IL)-6, IL-1beta and anti-inflammatory cytokines IL-1 receptor antagonist (IL-1RA) and IL-10. Alkaloids 43-52 C-C motif chemokine ligand 2 Homo sapiens 183-188 22592163-3 2012 This study focused on the ability of these alkaloids to modulate the gene expression of pro-inflammatory tumour necrosis factor alpha (TNF-alpha), monocyte chemoattractant protein 1 (MCP-1, also known as CCL-2), interleukin (IL)-6, IL-1beta and anti-inflammatory cytokines IL-1 receptor antagonist (IL-1RA) and IL-10. Alkaloids 43-52 C-C motif chemokine ligand 2 Homo sapiens 204-209 22592163-8 2012 Two hours after LPS stimulation, cells influenced by sanguinarine and chelerythrine significantly declined the CCL-2 expression by a factors of 3.5 (p<0.001) and 1.9 (p<0.01); for those treated with prednisone the factor was 5.3 (p<0.001). sanguinarine 53-65 C-C motif chemokine ligand 2 Homo sapiens 111-116 22592163-8 2012 Two hours after LPS stimulation, cells influenced by sanguinarine and chelerythrine significantly declined the CCL-2 expression by a factors of 3.5 (p<0.001) and 1.9 (p<0.01); for those treated with prednisone the factor was 5.3 (p<0.001). chelerythrine 70-83 C-C motif chemokine ligand 2 Homo sapiens 111-116 22592163-8 2012 Two hours after LPS stimulation, cells influenced by sanguinarine and chelerythrine significantly declined the CCL-2 expression by a factors of 3.5 (p<0.001) and 1.9 (p<0.01); for those treated with prednisone the factor was 5.3 (p<0.001). Prednisone 205-215 C-C motif chemokine ligand 2 Homo sapiens 111-116 22592163-9 2012 Eight hours after LPS induction, both alkaloids significantly diminished the CCL-2 expression. Alkaloids 38-47 C-C motif chemokine ligand 2 Homo sapiens 77-82 22592163-13 2012 Sanguinarine decreased gene expression of CCL-2 and IL-6 more than chelerythrine and its effect was quite similar to prednisone. sanguinarine 0-12 C-C motif chemokine ligand 2 Homo sapiens 42-47 22502743-5 2012 Inhibitors of NADPH oxidase, apocynin and diphenyleneiodonium, and a dual selective NOX1/4 inhibitor, blocked ROS generation (p<0.01) and induction of MCP-1 (p<0.05) by pro-inflammatory cytokines in beta cells. diphenyleneiodonium 42-61 C-C motif chemokine ligand 2 Homo sapiens 154-159 22517618-5 2012 Using selective EP receptor agonists and a selective EP(4) antagonist, we show that PGE(2) mediates the repression of IL-1beta-induced release of CXCL8, CCL2, and CSF2 via activation of the EP(2) and EP(4) receptors. Prostaglandins E 84-87 C-C motif chemokine ligand 2 Homo sapiens 153-157 22901451-13 2012 Untreated macrophages show dopamine mediated increases IL-6 and CCL2. Dopamine 27-35 C-C motif chemokine ligand 2 Homo sapiens 64-68 22561694-0 2012 Prostaglandin J2 series induces the gene expression of monocyte chemoattractant protein-1 during the maturation phase of cultured adipocytes. 9-deoxy-delta-9-prostaglandin D2 0-16 C-C motif chemokine ligand 2 Homo sapiens 55-89 22561694-6 2012 In addition, the increased transcription of MCP-1 was detectable at later maturation phase of adipogenesis, which was prevented by co-incubation with aspirin. Aspirin 150-157 C-C motif chemokine ligand 2 Homo sapiens 44-49 22561694-7 2012 Although 15d-PGJ(2) was more potent than Delta(12)-PGJ(2), both PGJ(2) derivatives series had similar effects to rescue dose-dependently the expression of the MCP-1 gene attenuated by aspirin. Aspirin 184-191 C-C motif chemokine ligand 2 Homo sapiens 159-164 22768975-11 2012 EGCG also inhibited the expression of MCP-1/CCL2, VCAM-1 and ICAM-1. epigallocatechin gallate 0-4 C-C motif chemokine ligand 2 Homo sapiens 44-48 22751874-5 2012 RESULTS: Mean (SD) chemokine ligand 2 (monocyte chemoattractant protein 1) levels were significantly higher (184.6 [101.1] vs 121.4 [55.8] pg/mL) at 12 months, as well as the increase in regulatory T-cell percentage (4.55% [1.5%] vs 3.34% [1.8%]) with cholecalciferol vs placebo. Cholecalciferol 252-267 C-C motif chemokine ligand 2 Homo sapiens 39-73 22753728-3 2012 MATERIALS AND METHODS: The cytotoxicity of carboxylato gold complexes 4-6 towards the HeLa (human cervix epithelioid) cancer cell line ATCC CCL-2, resting lymphocytes and phytohaemagglutinin(PHA)-stimulated lymphocytes were determined. carboxylato gold 43-59 C-C motif chemokine ligand 2 Homo sapiens 140-145 22299633-6 2012 When human EPCs were stimulated with LPS and nucleotides, ATP or UTP inhibited the expression of pro-inflammatory cytokines including MCP-1 (monocyte chemoattractant protein-1), IFNalpha (interferon alpha), TNFalpha (tumour necrosis factor alpha) and adhesion molecule VCAM-1 (vascular cell adhesion molecule 1) induced by LPS. Adenosine Triphosphate 58-61 C-C motif chemokine ligand 2 Homo sapiens 134-139 22299633-6 2012 When human EPCs were stimulated with LPS and nucleotides, ATP or UTP inhibited the expression of pro-inflammatory cytokines including MCP-1 (monocyte chemoattractant protein-1), IFNalpha (interferon alpha), TNFalpha (tumour necrosis factor alpha) and adhesion molecule VCAM-1 (vascular cell adhesion molecule 1) induced by LPS. Adenosine Triphosphate 58-61 C-C motif chemokine ligand 2 Homo sapiens 141-175 22299633-6 2012 When human EPCs were stimulated with LPS and nucleotides, ATP or UTP inhibited the expression of pro-inflammatory cytokines including MCP-1 (monocyte chemoattractant protein-1), IFNalpha (interferon alpha), TNFalpha (tumour necrosis factor alpha) and adhesion molecule VCAM-1 (vascular cell adhesion molecule 1) induced by LPS. Uridine Triphosphate 65-68 C-C motif chemokine ligand 2 Homo sapiens 134-139 22299633-6 2012 When human EPCs were stimulated with LPS and nucleotides, ATP or UTP inhibited the expression of pro-inflammatory cytokines including MCP-1 (monocyte chemoattractant protein-1), IFNalpha (interferon alpha), TNFalpha (tumour necrosis factor alpha) and adhesion molecule VCAM-1 (vascular cell adhesion molecule 1) induced by LPS. Uridine Triphosphate 65-68 C-C motif chemokine ligand 2 Homo sapiens 141-175 22469745-0 2012 Quercetin suppresses NF-kappaB and MCP-1 expression in a high glucose-induced human mesangial cell proliferation model. Quercetin 0-9 C-C motif chemokine ligand 2 Homo sapiens 35-40 22561121-3 2012 Zaprinast was found to activate ERK1/2, p38 MAPK, JNK, NFkappaB, and PI3K/Akt, and subsequently, induce the mRNA expressions of IL-1alpha, IL-1beta, TNF-alpha, CCL2, CCL4, CXCL1, CXCL2, and CD14. zaprinast 0-9 C-C motif chemokine ligand 2 Homo sapiens 160-164 22561121-6 2012 SP600125, PD98059, and LY294002 inhibited the induction of at least CCL2. pyrazolanthrone 0-8 C-C motif chemokine ligand 2 Homo sapiens 68-72 22561121-6 2012 SP600125, PD98059, and LY294002 inhibited the induction of at least CCL2. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 10-17 C-C motif chemokine ligand 2 Homo sapiens 68-72 22561121-6 2012 SP600125, PD98059, and LY294002 inhibited the induction of at least CCL2. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 23-31 C-C motif chemokine ligand 2 Homo sapiens 68-72 22441004-1 2012 OBJECTIVE: To observe the effects of pioglitazone hydrochloride on urinary sediment podocalyxin and monocyte chemoattractant protein-1 (MCP-1) excretion in patients with type 2 diabetes and to explore its possible renoprotective mechanisms. Pioglitazone 37-63 C-C motif chemokine ligand 2 Homo sapiens 100-134 22441004-4 2012 Moreover, the DP group showed significantly better efficacy in reducing urinary MCP-1 excretion in comparison with the DS group. dp 14-16 C-C motif chemokine ligand 2 Homo sapiens 80-85 22561123-6 2012 In addition, corilagin inhibits TNF-alpha induced secretion of MCP-1 and RANTES, exhibiting low or no effect on the release of G-CSF, IL-6 and VEGF. corilagin 13-22 C-C motif chemokine ligand 2 Homo sapiens 63-68 22469745-0 2012 Quercetin suppresses NF-kappaB and MCP-1 expression in a high glucose-induced human mesangial cell proliferation model. Glucose 62-69 C-C motif chemokine ligand 2 Homo sapiens 35-40 22469745-7 2012 HMCs cultured in high glucose had signficantly greater proliferation, accumulation in the G1 phase, upregulated NF-kappaB and MCP-1 expression. Glucose 22-29 C-C motif chemokine ligand 2 Homo sapiens 126-131 22694757-0 2012 ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion. fasudil 15-22 C-C motif chemokine ligand 2 Homo sapiens 55-60 22183741-7 2012 In addition, treatment of endometriotic stromal cells with curcumin markedly inhibited TNF-alpha-induced secretion of IL-6, IL-8 and MCP-1. Curcumin 59-67 C-C motif chemokine ligand 2 Homo sapiens 133-138 22523336-0 2012 Sex steroid-induced changes in circulating monocyte chemoattractant protein-1 levels may contribute to metabolic dysfunction in obese men. Steroids 4-11 C-C motif chemokine ligand 2 Homo sapiens 43-77 22523336-8 2012 In a separate clinical trial, the direct adverse effects of lowering testosterone and raising estradiol on MCP1 were substantiated in vivo. Estradiol 94-103 C-C motif chemokine ligand 2 Homo sapiens 107-111 22523336-10 2012 The direct adverse effects on MCP1, a chemokine highly linked to the development of metabolic dysfunction, were substantiated in a trial mimicking obesity-related alterations of sex steroid levels in healthy young males. Steroids 182-189 C-C motif chemokine ligand 2 Homo sapiens 30-34 22649203-8 2012 Omniscan and gadodiamide signaling via TLRs 4 and 7 resulted in increased production and expression of numerous proinflammatory/profibrotic cytokines, chemokines, and growth factors, including CXCL10, CCL2, CCL8, CXCL12, IL-4, IL-6, TGF-beta, and vascular endothelial growth factor. gadodiamide 0-8 C-C motif chemokine ligand 2 Homo sapiens 201-205 22649203-8 2012 Omniscan and gadodiamide signaling via TLRs 4 and 7 resulted in increased production and expression of numerous proinflammatory/profibrotic cytokines, chemokines, and growth factors, including CXCL10, CCL2, CCL8, CXCL12, IL-4, IL-6, TGF-beta, and vascular endothelial growth factor. gadodiamide 13-24 C-C motif chemokine ligand 2 Homo sapiens 201-205 22694757-0 2012 ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion. Glucose 39-46 C-C motif chemokine ligand 2 Homo sapiens 55-60 22694757-10 2012 Fasudil also decreased MCP-1 concentration in HUVEC supernatants, but increased sVCAM-1 shedding into the media. fasudil 0-7 C-C motif chemokine ligand 2 Homo sapiens 23-28 22694757-11 2012 In human diabetic subjects, 2 weeks of fasudil treatment significantly decreased serum MCP-1 level from 27.9 +- 10.6 pg/ml to 13.8 +- 7.0 pg/ml (P < 0.05), while sVCAM-1 increased from 23.2 +- 7.5 ng/ml to 39.7 +- 5.6 ng/ml after fasudil treatment (P < 0.05). fasudil 39-46 C-C motif chemokine ligand 2 Homo sapiens 87-92 22694757-12 2012 CONCLUSIONS: Treatment with the Rho/ROCK pathway inhibitor fasudil attenuated HG-induced monocyte-endothelial cell adhesion, possibly by reducing endothelial expression of VCAM-1 and MCP-1. fasudil 59-66 C-C motif chemokine ligand 2 Homo sapiens 183-188 22430974-7 2012 Rilpivirine induced the release of proinflammatory cytokines (interleukin-6 and -8, monocyte chemoattractant protein 1 [MCP-1], plasminogen activator inhibitor type 1 [PAI-1]) only at very high concentrations (10 muM). Rilpivirine 0-11 C-C motif chemokine ligand 2 Homo sapiens 84-118 22546346-9 2012 Dexamethasone inhibited the hydrogen peroxide-induced increase in MCP-1 and IP-10. Hydrogen Peroxide 28-45 C-C motif chemokine ligand 2 Homo sapiens 66-71 26593832-7 2012 We compared the binding affinity to N2 with various carbenes (:CF2, :CCl2, :CBr2, and :CI2). Nitrogen 36-38 C-C motif chemokine ligand 2 Homo sapiens 69-73 22546346-0 2012 Dexamethasone reduces bilirubin-induced toxicity and IL-8 and MCP-1 release in human NT2-N neurons. Dexamethasone 0-13 C-C motif chemokine ligand 2 Homo sapiens 62-67 22546346-6 2012 Dexamethasone significantly lowered the UCB-induced increase in MCP-1 release, and attenuated UCB-induced neuronal damage assessed with MTT cleavage and LDH release. Dexamethasone 0-13 C-C motif chemokine ligand 2 Homo sapiens 64-69 22546346-6 2012 Dexamethasone significantly lowered the UCB-induced increase in MCP-1 release, and attenuated UCB-induced neuronal damage assessed with MTT cleavage and LDH release. ucb 40-43 C-C motif chemokine ligand 2 Homo sapiens 64-69 22546346-8 2012 Hydrogen peroxide increased MCP-1, IP-10, and VEGF, but not IL-8, IL-13, or PDGF. Hydrogen Peroxide 0-17 C-C motif chemokine ligand 2 Homo sapiens 28-33 22546346-9 2012 Dexamethasone inhibited the hydrogen peroxide-induced increase in MCP-1 and IP-10. Dexamethasone 0-13 C-C motif chemokine ligand 2 Homo sapiens 66-71 22430974-7 2012 Rilpivirine induced the release of proinflammatory cytokines (interleukin-6 and -8, monocyte chemoattractant protein 1 [MCP-1], plasminogen activator inhibitor type 1 [PAI-1]) only at very high concentrations (10 muM). Rilpivirine 0-11 C-C motif chemokine ligand 2 Homo sapiens 120-125 21975431-2 2012 The aim of this study was to investigate the methylation status of CpG sites in the MCP-1 promoter in Type 2 diabetic patients and its correlation to serum MCP- 1 level, and blood glucose level. Glucose 180-187 C-C motif chemokine ligand 2 Homo sapiens 84-89 22415310-6 2012 ATP stimulation of P2Y(2) receptors increased alpha-smooth muscle actin (alpha-SMA) production, and in an ERK-dependent manner, ATP increased collagen accumulation by 60% and mRNA expression of profibrotic markers: plasminogen activator inhibitor-1 and monocyte chemotactic protein-1 by 4.5- and 4.0-fold, respectively. Adenosine Triphosphate 0-3 C-C motif chemokine ligand 2 Homo sapiens 253-283 22415310-6 2012 ATP stimulation of P2Y(2) receptors increased alpha-smooth muscle actin (alpha-SMA) production, and in an ERK-dependent manner, ATP increased collagen accumulation by 60% and mRNA expression of profibrotic markers: plasminogen activator inhibitor-1 and monocyte chemotactic protein-1 by 4.5- and 4.0-fold, respectively. Adenosine Triphosphate 128-131 C-C motif chemokine ligand 2 Homo sapiens 253-283 21975431-9 2012 CONCLUSION: These data suggest that hypomethylation of CpG sites in the MCP-1 promoter region may be affected by blood glucose and TG, which then increase the serum MCP-1 level and may play a role in the vascular complications of Type 2 diabetes. Glucose 119-126 C-C motif chemokine ligand 2 Homo sapiens 72-77 21975431-9 2012 CONCLUSION: These data suggest that hypomethylation of CpG sites in the MCP-1 promoter region may be affected by blood glucose and TG, which then increase the serum MCP-1 level and may play a role in the vascular complications of Type 2 diabetes. Glucose 119-126 C-C motif chemokine ligand 2 Homo sapiens 165-170 21975431-8 2012 MCP-1 promoter methylation was significantly correlated to serum MCP-1, HbA1c, fasting blood glucose, and triglyceride. Glucose 93-100 C-C motif chemokine ligand 2 Homo sapiens 0-5 21975431-8 2012 MCP-1 promoter methylation was significantly correlated to serum MCP-1, HbA1c, fasting blood glucose, and triglyceride. Triglycerides 106-118 C-C motif chemokine ligand 2 Homo sapiens 0-5 22487721-2 2012 Binding of CCL2 to its receptor CCR2 triggers calcium mobilization and chemotaxis. Calcium 46-53 C-C motif chemokine ligand 2 Homo sapiens 11-15 21840193-9 2012 These results suggest that linoleic acid-induced changes in monocyte chemotaxis and subsequent binding are not solely mediated by changes in adhesion molecule expression but may be due to secreted factors such as IL-8, monocyte chemoattractant protein-1 or prostaglandins (PGs) such as PGE(2), as IL-8 neutralisation and COX-2 inhibition reduced monocyte binding without changes in adhesion molecule expression. Linoleic Acid 27-40 C-C motif chemokine ligand 2 Homo sapiens 219-253 22222817-10 2012 Moreover, CCL2-stimulated microglia enhanced Akt phosphorylation by ATP applied extracellularly, a P2X4R-mediated response. Adenosine Triphosphate 68-71 C-C motif chemokine ligand 2 Homo sapiens 10-14 22345170-4 2012 Everolimus led to inhibition of protein translation, activation of p38 MAPK, and the release of proinflammatory cytokines (eg, IL-6, TNFalpha) and chemokines (eg, MCP1, Rantes) before induction of autophagic death. Everolimus 0-10 C-C motif chemokine ligand 2 Homo sapiens 163-167 22377751-0 2012 Calcium oxalate monohydrate crystals stimulate monocyte chemoattractant protein-1 and transforming growth factor beta1 expression in human renal epithelial cells. Calcium Oxalate 0-27 C-C motif chemokine ligand 2 Homo sapiens 47-93 22326051-5 2012 Treatment with leonurine blocked TNF-alpha-induced mRNA and protein expression of adhesion molecules (intercellular adhesion molecule-1 and vascular cell adhesion molecule-1), cyclooxygenase-2, and monocyte chemoattractant protein-1 in endothelial cells. leonurine 15-24 C-C motif chemokine ligand 2 Homo sapiens 198-232 22399514-11 2012 These cells produce high levels of several cytokines and chemokines including IL-8, regulated upon activation, normal T cell expressed and secreted, and monocyte chemoattractant protein-1 when treated with TSH or M22. Thyrotropin 206-209 C-C motif chemokine ligand 2 Homo sapiens 153-187 22558981-5 2012 RESULTS: Compared with the control group, the levels of the MCP-1 and FN in high glucose group were significantly increased with the expression peak at 48 h (P<0.01). Glucose 82-89 C-C motif chemokine ligand 2 Homo sapiens 61-66 22648625-9 2012 Uro-A inhibited endothelial cell migration and was able to decrease the expression of CCL2 and interleukin-8 (IL-8). 3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one 0-5 C-C motif chemokine ligand 2 Homo sapiens 86-90 22558981-0 2012 [Effect of mycophenolate on expression of MCP-1 and fibronectin in human mesangial cells induced by high glucose]. Mycophenolic Acid 11-24 C-C motif chemokine ligand 2 Homo sapiens 42-47 22558981-0 2012 [Effect of mycophenolate on expression of MCP-1 and fibronectin in human mesangial cells induced by high glucose]. Glucose 105-112 C-C motif chemokine ligand 2 Homo sapiens 42-47 22469443-6 2012 RESULTS: Serum levels of IL-8, MCP-1, and CCL-20 were significantly higher in the AS group than in the AR and NA groups. Arsenic 82-84 C-C motif chemokine ligand 2 Homo sapiens 31-36 22434621-6 2012 Vatiparol is unique in its unprecedented carbon skeleton and selective inhibitory effect on the expression of monocyte chemo-attractant protein-1 (MCP-1, also known as CCL2). vatiparol 0-9 C-C motif chemokine ligand 2 Homo sapiens 110-145 22434621-6 2012 Vatiparol is unique in its unprecedented carbon skeleton and selective inhibitory effect on the expression of monocyte chemo-attractant protein-1 (MCP-1, also known as CCL2). vatiparol 0-9 C-C motif chemokine ligand 2 Homo sapiens 147-152 22434621-6 2012 Vatiparol is unique in its unprecedented carbon skeleton and selective inhibitory effect on the expression of monocyte chemo-attractant protein-1 (MCP-1, also known as CCL2). vatiparol 0-9 C-C motif chemokine ligand 2 Homo sapiens 168-172 22326498-3 2012 MAIN METHODS: The effect of indoxyl sulfate on the expression of MCP-1 was determined using human proximal tubular cells (HK-2 cells) and following animals: (1) Dahl salt-resistant normotensive rats (DN), (2) Dahl salt-resistant normotensive indoxyl sulfate-administered rats (DN+IS), (3) Dahl salt-sensitive hypertensive rats (DH), and (4) Dahl salt-sensitive hypertensive indoxyl sulfate-administered rats (DH+IS). Indican 28-43 C-C motif chemokine ligand 2 Homo sapiens 65-70 22326498-3 2012 MAIN METHODS: The effect of indoxyl sulfate on the expression of MCP-1 was determined using human proximal tubular cells (HK-2 cells) and following animals: (1) Dahl salt-resistant normotensive rats (DN), (2) Dahl salt-resistant normotensive indoxyl sulfate-administered rats (DN+IS), (3) Dahl salt-sensitive hypertensive rats (DH), and (4) Dahl salt-sensitive hypertensive indoxyl sulfate-administered rats (DH+IS). dahl salt 161-170 C-C motif chemokine ligand 2 Homo sapiens 65-70 22246000-0 2012 Ciclesonide inhibits TNFalpha- and IL-1beta-induced monocyte chemotactic protein-1 (MCP-1/CCL2) secretion from human airway smooth muscle cells. ciclesonide 0-11 C-C motif chemokine ligand 2 Homo sapiens 52-82 22246000-0 2012 Ciclesonide inhibits TNFalpha- and IL-1beta-induced monocyte chemotactic protein-1 (MCP-1/CCL2) secretion from human airway smooth muscle cells. ciclesonide 0-11 C-C motif chemokine ligand 2 Homo sapiens 84-89 22246000-0 2012 Ciclesonide inhibits TNFalpha- and IL-1beta-induced monocyte chemotactic protein-1 (MCP-1/CCL2) secretion from human airway smooth muscle cells. ciclesonide 0-11 C-C motif chemokine ligand 2 Homo sapiens 90-94 22246000-9 2012 Formoterol had no effect on MCP-1 expression, while ciclesonide significantly inhibited IL-1beta- and TNFalpha-induced MCP-1. ciclesonide 52-63 C-C motif chemokine ligand 2 Homo sapiens 119-124 22246000-10 2012 Furthermore, ciclesonide inhibited IL-1beta- and TNFalpha-induced MCP-1 mRNA and IL-1beta- and TNFalpha-induced MCP-1 promoter and enhancer luciferase reporters. ciclesonide 13-24 C-C motif chemokine ligand 2 Homo sapiens 66-71 22246000-10 2012 Furthermore, ciclesonide inhibited IL-1beta- and TNFalpha-induced MCP-1 mRNA and IL-1beta- and TNFalpha-induced MCP-1 promoter and enhancer luciferase reporters. ciclesonide 13-24 C-C motif chemokine ligand 2 Homo sapiens 112-117 22305882-3 2012 We found that leonurine pretreatment concentration-dependently attenuated LPS-induced mRNA expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), E-selectin, and monocyte chemoattractant protein-1. leonurine 14-23 C-C motif chemokine ligand 2 Homo sapiens 209-243 21701898-0 2012 Differential effects of 1alpha,25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes. Calcitriol 24-58 C-C motif chemokine ligand 2 Homo sapiens 62-67 22385239-5 2012 Glutamic acid decarboxylase-65 (GAD-65) autoantibodies (GADA) were associated negatively with CXCL10 (r = -0 45; P = 0 011) and CCL2 (r = -0 65; P = 0 000), while IA-2A showed a negative correlation with IL-10 (r = -0 38; P = 0 027). gada 56-60 C-C motif chemokine ligand 2 Homo sapiens 128-132 22146696-10 2012 Accordingly, the same BA-doses inhibited the expression of pro-inflammatory and NFkappaB regulated genes as MCP-1 and RANTES, but did not affect expression of genes not related to NFkappaB signaling. Barium 22-24 C-C motif chemokine ligand 2 Homo sapiens 108-113 21701898-9 2012 DHCC attenuated TNFalpha-induced CCL2 mRNA expression in both pre-incubation (~15%, p < 0.05) and concomitant (~60%, p < 0.01) treatments. Calcitriol 0-4 C-C motif chemokine ligand 2 Homo sapiens 33-37 21701898-13 2012 CONCLUSIONS: DHCC attenuates MCP-1 and adiponectin production in human adipocytes, thereby reducing the expression of both pro- and anti-inflammatory factors. Calcitriol 13-17 C-C motif chemokine ligand 2 Homo sapiens 29-34 22218934-5 2012 Gallic acid caused a decrease in the secretion of MCP-1, ICAM-1, and VCAM-1 in endothelial cells. Gallic Acid 0-11 C-C motif chemokine ligand 2 Homo sapiens 50-55 22293775-5 2012 gamma-tocotrienol effectively improved the TNF-alpha-induced adverse changes in MCP-1, IL-6 and adiponectin secretion, and in MCP-1, IL-6, adiponectin and PPARgamma mRNA expression. plastochromanol 8 0-17 C-C motif chemokine ligand 2 Homo sapiens 80-85 22050507-8 2012 RESULTS: Indomethacin and indomethacin-releasing stent material inhibited MCP-1 and RANTES production in activated THP-1 macrophages. Indomethacin 9-21 C-C motif chemokine ligand 2 Homo sapiens 74-79 22050507-8 2012 RESULTS: Indomethacin and indomethacin-releasing stent material inhibited MCP-1 and RANTES production in activated THP-1 macrophages. Indomethacin 26-38 C-C motif chemokine ligand 2 Homo sapiens 74-79 22293775-0 2012 gamma-Tocotrienol attenuates TNF-alpha-induced changes in secretion and gene expression of MCP-1, IL-6 and adiponectin in 3T3-L1 adipocytes. plastochromanol 8 0-17 C-C motif chemokine ligand 2 Homo sapiens 91-96 22293775-5 2012 gamma-tocotrienol effectively improved the TNF-alpha-induced adverse changes in MCP-1, IL-6 and adiponectin secretion, and in MCP-1, IL-6, adiponectin and PPARgamma mRNA expression. plastochromanol 8 0-17 C-C motif chemokine ligand 2 Homo sapiens 126-131 22189196-8 2012 The high-salt intake markedly increased plasma tumor necrosis factor-alpha (P < 0.0001) and monocyte chemoattractant protein-1 (P < 0.0001) in normotensive salt-sensitive and salt-resistant subjects. Salts 9-13 C-C motif chemokine ligand 2 Homo sapiens 95-129 22189196-8 2012 The high-salt intake markedly increased plasma tumor necrosis factor-alpha (P < 0.0001) and monocyte chemoattractant protein-1 (P < 0.0001) in normotensive salt-sensitive and salt-resistant subjects. Salts 162-166 C-C motif chemokine ligand 2 Homo sapiens 95-129 22189196-8 2012 The high-salt intake markedly increased plasma tumor necrosis factor-alpha (P < 0.0001) and monocyte chemoattractant protein-1 (P < 0.0001) in normotensive salt-sensitive and salt-resistant subjects. Salts 162-166 C-C motif chemokine ligand 2 Homo sapiens 95-129 22169009-8 2012 Immunohistochemistry showed that calcitriol and paricalcitol reduced MCP-1 and IL-6 in podocytes and tubular cells as well as glomerular infiltration by macrophages, glomerular cell NF-kappaB activation, apoptosis, and extracellular matrix deposition. Calcitriol 33-43 C-C motif chemokine ligand 2 Homo sapiens 69-74 22169009-8 2012 Immunohistochemistry showed that calcitriol and paricalcitol reduced MCP-1 and IL-6 in podocytes and tubular cells as well as glomerular infiltration by macrophages, glomerular cell NF-kappaB activation, apoptosis, and extracellular matrix deposition. paricalcitol 48-60 C-C motif chemokine ligand 2 Homo sapiens 69-74 22169009-9 2012 In cultured podocytes, paricalcitol and calcitriol at concentrations in the physiological and clinically significant range prevented the increase in MCP-1, IL-6, renin, and fibronectin mRNA expression and the secretion of MCP-1 to the culture media induced by high glucose. paricalcitol 23-35 C-C motif chemokine ligand 2 Homo sapiens 149-154 22169009-9 2012 In cultured podocytes, paricalcitol and calcitriol at concentrations in the physiological and clinically significant range prevented the increase in MCP-1, IL-6, renin, and fibronectin mRNA expression and the secretion of MCP-1 to the culture media induced by high glucose. paricalcitol 23-35 C-C motif chemokine ligand 2 Homo sapiens 222-227 22169009-9 2012 In cultured podocytes, paricalcitol and calcitriol at concentrations in the physiological and clinically significant range prevented the increase in MCP-1, IL-6, renin, and fibronectin mRNA expression and the secretion of MCP-1 to the culture media induced by high glucose. Calcitriol 40-50 C-C motif chemokine ligand 2 Homo sapiens 149-154 22169009-9 2012 In cultured podocytes, paricalcitol and calcitriol at concentrations in the physiological and clinically significant range prevented the increase in MCP-1, IL-6, renin, and fibronectin mRNA expression and the secretion of MCP-1 to the culture media induced by high glucose. Calcitriol 40-50 C-C motif chemokine ligand 2 Homo sapiens 222-227 22169009-9 2012 In cultured podocytes, paricalcitol and calcitriol at concentrations in the physiological and clinically significant range prevented the increase in MCP-1, IL-6, renin, and fibronectin mRNA expression and the secretion of MCP-1 to the culture media induced by high glucose. Glucose 265-272 C-C motif chemokine ligand 2 Homo sapiens 222-227 22414048-8 2012 RESULTS: Multiple inflammatory mediators were inhibited by methoxyphenols, including: CCL2, CCL5, IL-6, IL-8, ICAM-1, MIF, CXCL1, CXCL10, and Serpin E1. Guaiacol 59-73 C-C motif chemokine ligand 2 Homo sapiens 86-90 22334674-4 2012 Depletion of lipin-2 promotes the increased expression of the proinflammatory genes Il6, Ccl2, and Tnfalpha, which depends on the overstimulation of the JNK1/c-Jun pathway by saturated fatty acids. Fatty Acids 175-196 C-C motif chemokine ligand 2 Homo sapiens 89-93 20456252-9 2012 One week after IVTA, the FT was significantly decreased (p < 0.001), and the levels of MCP-1 and MIP-1beta were also significantly reduced (p < 0.001 and p = 0.044, respectively). ivta 15-19 C-C motif chemokine ligand 2 Homo sapiens 90-95 22330806-1 2012 Although white adipocytes contain a larger number of mitochondria per cytoplasmic volume, adipocyte mitochondrial uncoupling to reduce the efficiency of ATP production on cellular function including secretory regulation of bioactive molecules such as VEGF and MCP-1 remains to be elucidated. Adenosine Triphosphate 153-156 C-C motif chemokine ligand 2 Homo sapiens 260-265 22330806-3 2012 MCP-1 release was significantly decreased by 26% (p<0.01) in 24h DNP (30 mumol/L)-treated adipocytes compared to control cells. Dinitrophenols 68-71 C-C motif chemokine ligand 2 Homo sapiens 0-5 22330806-6 2012 Treatment with thapsigargin, which can induce exogenous endoplasmic reticulum (ER) stress, clearly attenuated MCP-1 release (p<0.01), but exhibited no effects on VEGF(120) secretion. Thapsigargin 15-27 C-C motif chemokine ligand 2 Homo sapiens 110-115 21913898-2 2012 This study assessed the effects of the PDE4 inhibitor roflumilast and its active metabolite, roflumilast N-oxide on the release of a range of chemokines (CCL2, 3, 4, CXCL1, 8, 10) and of TNF-alpha, from human lung macrophages, stimulated with bacterial lipopolysaccharide LPS. Roflumilast 54-65 C-C motif chemokine ligand 2 Homo sapiens 154-158 22177985-1 2012 The truncated [1+9-76] CCL2 analogue, also known as 7ND, has been described in numerous reports as an anti-inflammatory and anti-fibrotic agent in a wide spectrum of animal models, e.g. models of cardiovascular disease, graft versus host disease and bleomycin-induced pulmonary fibrosis. Bleomycin 250-259 C-C motif chemokine ligand 2 Homo sapiens 23-27 21726210-6 2012 KEY RESULTS: Azithromycin (1.5-50 microM) dose-dependently inhibited gene expression and/or release of M1 macrophage markers (CCR7, CXCL 11 and IL-12p70), but enhanced CCL2, without altering TNF-alpha or IL-6. Azithromycin 13-25 C-C motif chemokine ligand 2 Homo sapiens 168-172 22226738-8 2012 ARB also significantly suppressed MCP-1 expression in C4-2AT6 tumors. beta-L-Arabinose 0-3 C-C motif chemokine ligand 2 Homo sapiens 34-39 22155371-7 2012 Hyperglycemia-induced enhanced levels of VEGF, ICAM-1, MCP-1 and IL-6 in the plasma of STZ treated animals indicate vascular inflammation in T1DM. Streptozocin 87-90 C-C motif chemokine ligand 2 Homo sapiens 55-60 21913898-2 2012 This study assessed the effects of the PDE4 inhibitor roflumilast and its active metabolite, roflumilast N-oxide on the release of a range of chemokines (CCL2, 3, 4, CXCL1, 8, 10) and of TNF-alpha, from human lung macrophages, stimulated with bacterial lipopolysaccharide LPS. n-oxide 105-112 C-C motif chemokine ligand 2 Homo sapiens 154-158 21913898-8 2012 Roflumilast and roflumilast N-oxide concentration-dependently reduced the LPS-stimulated release of CCL2, CCL3, CCL4, CXCL10 and TNF-alpha from human lung macrophages, whereas that of CXCL1 or CXCL8 was not altered. n-oxide 28-35 C-C motif chemokine ligand 2 Homo sapiens 100-104 21913898-12 2012 CONCLUSIONS AND IMPLICATIONS: Roflumilast and roflumilast N-oxide reduced LPS-induced release of CCL2, 3, 4, CXCL10 and TNF-alpha in human lung macrophages. n-oxide 58-65 C-C motif chemokine ligand 2 Homo sapiens 97-107 21632263-9 2012 Levels of soluble MCP-1 and MMP-1 in supernatants were lower after preincubation with nicotinic acid. Niacin 86-100 C-C motif chemokine ligand 2 Homo sapiens 18-23 22109668-8 2012 The TBR as well as high-sensitivity C-reactive protein (hsCRP), E-selectin, MMP-9, monocyte chemotactic protein 1, FABP4 and follistatin values were reduced significantly after the 12-week atorvastatin treatment. Atorvastatin 189-201 C-C motif chemokine ligand 2 Homo sapiens 83-113 22565056-7 2012 PGE(2) dampened early production of the inflammatory chemokines CCL2, CCL4, CCL5 and attenuated the expression of the T cell attractant CXCL10. Prostaglandins E 0-3 C-C motif chemokine ligand 2 Homo sapiens 64-68 22691208-5 2012 RESULTS: MCP1/CCL2, RANTES/CCL5 and MIP1alpha/CCL3 levels were significantly higher in SSc patients than in controls and significantly decreased after PGE1 treatment. Alprostadil 151-155 C-C motif chemokine ligand 2 Homo sapiens 9-13 22691208-5 2012 RESULTS: MCP1/CCL2, RANTES/CCL5 and MIP1alpha/CCL3 levels were significantly higher in SSc patients than in controls and significantly decreased after PGE1 treatment. Alprostadil 151-155 C-C motif chemokine ligand 2 Homo sapiens 14-18 22691208-8 2012 PGE1 down-regulates serum MCP1/CCL2 and RANTES/CCL5 levels, suggesting its possible additional effect on inflammation and cell trafficking in SSc. Alprostadil 0-4 C-C motif chemokine ligand 2 Homo sapiens 26-30 22691208-8 2012 PGE1 down-regulates serum MCP1/CCL2 and RANTES/CCL5 levels, suggesting its possible additional effect on inflammation and cell trafficking in SSc. Alprostadil 0-4 C-C motif chemokine ligand 2 Homo sapiens 31-35 22315307-8 2012 SkMCs released IL-6, IL-8, and monocyte chemoattractant protein-1 on Hsp60 stimulation. skmcs 0-5 C-C motif chemokine ligand 2 Homo sapiens 31-65 22228203-7 2012 Associations of the MCP1-TNF-alpha pattern with loci in several biologically plausible genes [CYP4F8 (rs3764563), APBB1IP (rs1775246), COL13A1 (rs2683572), and COMMD10 (rs1396485)] approached genome-wide significance (P=3x10, 5x10, 6x10, and 7x10, respectively) before fenofibrate treatment. Fenofibrate 269-280 C-C motif chemokine ligand 2 Homo sapiens 20-24 22116002-6 2012 Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1. Poly I-C 0-8 C-C motif chemokine ligand 2 Homo sapiens 50-55 22116002-6 2012 Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1. Poly I-C 0-8 C-C motif chemokine ligand 2 Homo sapiens 174-179 22116002-6 2012 Poly(I:C) stimulated the secretion of IL-6, IL-8, MCP-1, RANTES, IP-10, eotaxin, MIP-1beta, and interferon-gamma, whereas zymosan triggered the production of IL-6, IL-8, and MCP-1. Zymosan 122-129 C-C motif chemokine ligand 2 Homo sapiens 174-179 22116002-7 2012 LPS, poly(I:C), and zymosan thus each induced a distinct pattern of cytokine and chemokine release from human corneal fibroblasts, with the release of IL-6, IL-8, and MCP-1 being commonly elicited by all three agents. Poly I-C 5-14 C-C motif chemokine ligand 2 Homo sapiens 167-172 22116002-7 2012 LPS, poly(I:C), and zymosan thus each induced a distinct pattern of cytokine and chemokine release from human corneal fibroblasts, with the release of IL-6, IL-8, and MCP-1 being commonly elicited by all three agents. Zymosan 20-27 C-C motif chemokine ligand 2 Homo sapiens 167-172 22020763-12 2012 Importantly, NFkappa B and p38 MAPK signaling pathways, which were activated by NOX-derived ROS, were involved in CRP-induced monocyte-endothelial cell adhesion and up-regulation of MCP-1 expression. Reactive Oxygen Species 92-95 C-C motif chemokine ligand 2 Homo sapiens 182-187 22381103-0 2012 Effects of 17beta-estradiol on the release of monocyte chemotactic protein-1 and MAPK activity in monocytes stimulated with peritoneal fluid from endometriosis patients. Estradiol 11-27 C-C motif chemokine ligand 2 Homo sapiens 46-76 22381103-4 2012 RESULTS: E2 down-regulated MCP-1 release by lipopolysaccharide- or cPF-treated monocytes, but failed to suppress its release by ePF-treated monocytes. cpf 67-70 C-C motif chemokine ligand 2 Homo sapiens 27-32 22381103-5 2012 The release of MCP-1 by ePF- and cPF-treated monocytes was efficiently abrogated by p38 mitogen activated protein kinase (MAPK) inhibitors; however, the MCP-1 release by cPF-treated monocytes, but not by ePF-treated monocytes, was blocked by a MAPK kinase inhibitor. cpf 33-36 C-C motif chemokine ligand 2 Homo sapiens 15-20 22100460-6 2012 Compared with AGEs-modified BSA prepared without metformin (AGEs-MF0), those prepared in the presence of 30 mM or 100 mM metformin (AGEs-MF30 or AGEs-MF100) significantly reduced RAGE mRNA level, reactive oxygen species (ROS) generation, apoptosis, monocyte chemoattractant protein-1 and transforming growth factor-beta mRNA level in tubular cells. Metformin 121-130 C-C motif chemokine ligand 2 Homo sapiens 249-319 22228203-8 2012 After fenofibrate treatment, the rs12722605 locus in IL2RA was also associated with the MCP1-TNF-alpha pattern (P=3x10). Fenofibrate 6-17 C-C motif chemokine ligand 2 Homo sapiens 88-92 22611924-6 2012 CONCLUSION: The expression of NF-kappaB, MCP-1, IL-1beta, IL-6 and IL-8 in HUVECs up-regulated by TNF-alpha was promoted by CIT. citreoviridin 124-127 C-C motif chemokine ligand 2 Homo sapiens 41-46 22611924-0 2012 [Effects of citreoviridin on the expression of MCP-1 and ILs induced by TNF-alpha in vein endothelial cells]. citreoviridin 12-25 C-C motif chemokine ligand 2 Homo sapiens 47-52 22611924-1 2012 OBJECTIVE: To investigate the effects of citreoviridin (CIT) on the expression of MCP-1, IL-1beta, IL-6 and IL-8 induced by TNF-alpha in human umbilical vein endothelial cells (HUVECs). citreoviridin 41-54 C-C motif chemokine ligand 2 Homo sapiens 82-87 22611924-1 2012 OBJECTIVE: To investigate the effects of citreoviridin (CIT) on the expression of MCP-1, IL-1beta, IL-6 and IL-8 induced by TNF-alpha in human umbilical vein endothelial cells (HUVECs). citreoviridin 56-59 C-C motif chemokine ligand 2 Homo sapiens 82-87 22332224-0 2012 Downregulation of monocyte chemoattractant protein 1 expression by prostaglandin E(2) in human ocular surface epithelium. Dinoprostone 67-85 C-C motif chemokine ligand 2 Homo sapiens 18-52 22205309-7 2012 Both ethanol and phenolic compounds of RW downregulated serum concentrations of CD40 antigen, CD40 ligand, IL-16, monocyte chemotactic protein-1, and vascular cell adhesion molecule-1. Ethanol 5-12 C-C motif chemokine ligand 2 Homo sapiens 114-144 22095986-3 2012 METHODS AND RESULTS: Chronic exposure of monocytes to diabetic conditions induced by human LDL plus high D-glucose concentrations (LDL+HG) promoted NADPH Oxidase 4 (Nox4) expression, increased intracellular H(2)O(2) formation, stimulated protein S-glutathionylation, and increased chemotaxis in response to MCP-1, platelet-derived growth factor B, and RANTES. Glucose 105-114 C-C motif chemokine ligand 2 Homo sapiens 307-312 21707612-7 2012 Analysis of hepatic gene expression showed that both conjugates significantly reduced Gal/LPS-mediated expression of chemoattractants, such as monocyte chemotactic protein 1 (MCP1) and RANTES. cyclohexenoesculetin-beta-galactoside 86-89 C-C motif chemokine ligand 2 Homo sapiens 143-173 22868806-8 2012 Linear regression analysis showed significant and direct correlations among serum MCP-1 concentration and lactate levels at baseline. Lactic Acid 106-113 C-C motif chemokine ligand 2 Homo sapiens 82-87 21707612-7 2012 Analysis of hepatic gene expression showed that both conjugates significantly reduced Gal/LPS-mediated expression of chemoattractants, such as monocyte chemotactic protein 1 (MCP1) and RANTES. cyclohexenoesculetin-beta-galactoside 86-89 C-C motif chemokine ligand 2 Homo sapiens 175-179 21494800-8 2012 Nicotine upregulated OPN, IL-6, and MCP-1 expressions, and this effect attenuated after PDTC pretreatment. Nicotine 0-8 C-C motif chemokine ligand 2 Homo sapiens 36-41 22132892-5 2012 The basal secretion of CCL2 by PBMC or induced by Staphylococcus aureus enterotoxin A (SEA) was higher in CIU patients than in the control group, as well as for CXCL8 and CCL5 secretions upon phytohaemagglutinin stimulation. PBMC 31-35 C-C motif chemokine ligand 2 Homo sapiens 23-27 21900689-4 2012 When peroxides associated with Ox-LDL were reduced to hydroxides, the ability to induce BNP and MCP-1 gene expression was abolished. Peroxides 5-14 C-C motif chemokine ligand 2 Homo sapiens 96-101 21900689-4 2012 When peroxides associated with Ox-LDL were reduced to hydroxides, the ability to induce BNP and MCP-1 gene expression was abolished. Hydroxides 54-64 C-C motif chemokine ligand 2 Homo sapiens 96-101 23123466-6 2012 CAPE significantly suppressed the levels of lipopolysaccharide (LPS)-induced interleukin (IL)-1-beta, tumor necrosis factor (TNF)-alpha and monocyte chemoattractant protein (MCP)-1 from a macrophage cell line, RAW264.7. caffeic acid phenethyl ester 0-4 C-C motif chemokine ligand 2 Homo sapiens 140-180 23095175-0 2012 Intracoronary monocyte chemoattractant protein 1 and vascular endothelial growth factor levels are associated with necrotic core, calcium and fibrous tissue atherosclerotic plaque components: an intracoronary ultrasound radiofrequency study. Calcium 130-137 C-C motif chemokine ligand 2 Homo sapiens 14-48 22112811-9 2012 Two candidate plasma factors, glucose and the saturated fatty acid palmitic acid, did not affect proliferation or adipocyte differentiation in vitro but were found to increase CCL2 (monocyte chemoattractant protein-1) secretion by adipocytes. Glucose 30-37 C-C motif chemokine ligand 2 Homo sapiens 176-180 22112811-9 2012 Two candidate plasma factors, glucose and the saturated fatty acid palmitic acid, did not affect proliferation or adipocyte differentiation in vitro but were found to increase CCL2 (monocyte chemoattractant protein-1) secretion by adipocytes. Glucose 30-37 C-C motif chemokine ligand 2 Homo sapiens 182-216 22112811-9 2012 Two candidate plasma factors, glucose and the saturated fatty acid palmitic acid, did not affect proliferation or adipocyte differentiation in vitro but were found to increase CCL2 (monocyte chemoattractant protein-1) secretion by adipocytes. Fatty Acids 46-66 C-C motif chemokine ligand 2 Homo sapiens 176-180 22112811-9 2012 Two candidate plasma factors, glucose and the saturated fatty acid palmitic acid, did not affect proliferation or adipocyte differentiation in vitro but were found to increase CCL2 (monocyte chemoattractant protein-1) secretion by adipocytes. Fatty Acids 46-66 C-C motif chemokine ligand 2 Homo sapiens 182-216 22112811-9 2012 Two candidate plasma factors, glucose and the saturated fatty acid palmitic acid, did not affect proliferation or adipocyte differentiation in vitro but were found to increase CCL2 (monocyte chemoattractant protein-1) secretion by adipocytes. Palmitic Acid 67-80 C-C motif chemokine ligand 2 Homo sapiens 176-180 22112811-9 2012 Two candidate plasma factors, glucose and the saturated fatty acid palmitic acid, did not affect proliferation or adipocyte differentiation in vitro but were found to increase CCL2 (monocyte chemoattractant protein-1) secretion by adipocytes. Palmitic Acid 67-80 C-C motif chemokine ligand 2 Homo sapiens 182-216 22185690-2 2012 LL-23 demonstrated, compared to LL-37, a conserved ability to induce the chemokine MCP-1 in human peripheral blood mononuclear cells, a lack of ability to suppress induction of the pro-inflammatory cytokine TNF-alpha in response to bacterial lipopolysaccharides (LPS), and reduced antimicrobial activity. LL-23 0-5 C-C motif chemokine ligand 2 Homo sapiens 83-88 22466558-5 2012 Reverse transcription polymerase chain reaction (RT-PCR) analysis revealed that gallotannin significantly attenuated oxalate-induced mRNA and protein expressions of monocyte chemoattractant protein 1 (MCP-1), osteopontin (OPN), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunit p22(phox) and p47(phox) in human primary renal epithelial cells (HRCs). Oxalates 117-124 C-C motif chemokine ligand 2 Homo sapiens 165-199 22466558-5 2012 Reverse transcription polymerase chain reaction (RT-PCR) analysis revealed that gallotannin significantly attenuated oxalate-induced mRNA and protein expressions of monocyte chemoattractant protein 1 (MCP-1), osteopontin (OPN), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunit p22(phox) and p47(phox) in human primary renal epithelial cells (HRCs). Oxalates 117-124 C-C motif chemokine ligand 2 Homo sapiens 201-206 22086137-9 2012 Our results show that high glucose concentrations (12 mM and particularly 24 mM) alter the biomineralization process in osteoblastic cells and provoke the following: i) a rise in mineralization, ii) an increase in the mRNA expression of RANKL and a decrease of OPG, iii) an increase in the mRNA expression of osteocalcin, bone sialoprotein and the transcription factor Runx2, iv) a diminished quality of the mineral, and v) an increase in the expression of IL1beta, IL6, IL8, MCP-1 and IL10 mRNAs. Glucose 27-34 C-C motif chemokine ligand 2 Homo sapiens 476-481 22132892-7 2012 The findings showed a high responsiveness of monocytes through CCL2/CXCL8 expression, contributing to the creation of a proinflammatory environment in CIU. n-cyclohexyl-n'-(4-iodophenyl)urea 151-154 C-C motif chemokine ligand 2 Homo sapiens 63-67 22680639-5 2012 Pre-treatment of cells with 3,4-DHPEA-EDA resulted in a dose-dependent inhibition of CCL2 secretion. 3,4-dihydroxyphenylethanol 28-37 C-C motif chemokine ligand 2 Homo sapiens 85-89 22680639-6 2012 The effect of 3,4-DHPEA-EDA on CCL2 expression was observed at the transcriptional level. 3,4-dihydroxyphenylethanol 14-23 C-C motif chemokine ligand 2 Homo sapiens 31-35 22028071-10 2012 Both types of vitamin D contributed to a decrease in five out of seven markers of innate immunity, significantly more pronounced with HyD for eotaxin, IL-12, MCP-1, and MIP-1 beta. Vitamin D 14-23 C-C motif chemokine ligand 2 Homo sapiens 158-163 22942727-2 2012 Preclinical studies indicate that treatment with acetylsalicylic acid + extended-release dipyridamole (ASA + ER-DP) has anti-inflammatory and thereby neuroprotective effects by inhibition of monocyte chemotactic protein-1 (MCP-1) expression. Aspirin 49-69 C-C motif chemokine ligand 2 Homo sapiens 191-221 22942727-2 2012 Preclinical studies indicate that treatment with acetylsalicylic acid + extended-release dipyridamole (ASA + ER-DP) has anti-inflammatory and thereby neuroprotective effects by inhibition of monocyte chemotactic protein-1 (MCP-1) expression. Aspirin 49-69 C-C motif chemokine ligand 2 Homo sapiens 223-228 22942727-2 2012 Preclinical studies indicate that treatment with acetylsalicylic acid + extended-release dipyridamole (ASA + ER-DP) has anti-inflammatory and thereby neuroprotective effects by inhibition of monocyte chemotactic protein-1 (MCP-1) expression. extended-release 72-88 C-C motif chemokine ligand 2 Homo sapiens 191-221 22942727-2 2012 Preclinical studies indicate that treatment with acetylsalicylic acid + extended-release dipyridamole (ASA + ER-DP) has anti-inflammatory and thereby neuroprotective effects by inhibition of monocyte chemotactic protein-1 (MCP-1) expression. extended-release 72-88 C-C motif chemokine ligand 2 Homo sapiens 223-228 22942727-2 2012 Preclinical studies indicate that treatment with acetylsalicylic acid + extended-release dipyridamole (ASA + ER-DP) has anti-inflammatory and thereby neuroprotective effects by inhibition of monocyte chemotactic protein-1 (MCP-1) expression. Dipyridamole 89-101 C-C motif chemokine ligand 2 Homo sapiens 191-221 22942727-2 2012 Preclinical studies indicate that treatment with acetylsalicylic acid + extended-release dipyridamole (ASA + ER-DP) has anti-inflammatory and thereby neuroprotective effects by inhibition of monocyte chemotactic protein-1 (MCP-1) expression. Dipyridamole 89-101 C-C motif chemokine ligand 2 Homo sapiens 223-228 22942727-2 2012 Preclinical studies indicate that treatment with acetylsalicylic acid + extended-release dipyridamole (ASA + ER-DP) has anti-inflammatory and thereby neuroprotective effects by inhibition of monocyte chemotactic protein-1 (MCP-1) expression. Aspirin 103-106 C-C motif chemokine ligand 2 Homo sapiens 191-221 22942727-2 2012 Preclinical studies indicate that treatment with acetylsalicylic acid + extended-release dipyridamole (ASA + ER-DP) has anti-inflammatory and thereby neuroprotective effects by inhibition of monocyte chemotactic protein-1 (MCP-1) expression. Aspirin 103-106 C-C motif chemokine ligand 2 Homo sapiens 223-228 22942727-2 2012 Preclinical studies indicate that treatment with acetylsalicylic acid + extended-release dipyridamole (ASA + ER-DP) has anti-inflammatory and thereby neuroprotective effects by inhibition of monocyte chemotactic protein-1 (MCP-1) expression. er-dp 109-114 C-C motif chemokine ligand 2 Homo sapiens 191-221 22942727-2 2012 Preclinical studies indicate that treatment with acetylsalicylic acid + extended-release dipyridamole (ASA + ER-DP) has anti-inflammatory and thereby neuroprotective effects by inhibition of monocyte chemotactic protein-1 (MCP-1) expression. er-dp 109-114 C-C motif chemokine ligand 2 Homo sapiens 223-228 22942727-3 2012 We hypothesized that early treatment with ASA + ER-DP will reduce levels of MCP-1 also in patients with ischemic stroke. Aspirin 42-45 C-C motif chemokine ligand 2 Homo sapiens 76-81 22942727-3 2012 We hypothesized that early treatment with ASA + ER-DP will reduce levels of MCP-1 also in patients with ischemic stroke. er-dp 48-53 C-C motif chemokine ligand 2 Homo sapiens 76-81 22942727-8 2012 Comparisons within MCP-1 baseline quartiles indicated that patients in the highest quartile (>217-973 pg/mL) showed improved outcome at 90 days if treated with ASA + ER-DP in comparison to treatment with ASA alone (p = 0.004). Aspirin 163-166 C-C motif chemokine ligand 2 Homo sapiens 19-24 22942727-8 2012 Comparisons within MCP-1 baseline quartiles indicated that patients in the highest quartile (>217-973 pg/mL) showed improved outcome at 90 days if treated with ASA + ER-DP in comparison to treatment with ASA alone (p = 0.004). er-dp 169-174 C-C motif chemokine ligand 2 Homo sapiens 19-24 22021706-6 2012 In vitro, high glucose induced TLR4 expression via protein kinase C activation in a time- and dose-dependent manner, resulting in upregulation of IL-6 and chemokine (C-C motif) ligand 2 (CCL-2) expression via IkappaB/NF-kappaB activation in human proximal tubular epithelial cells. Glucose 15-22 C-C motif chemokine ligand 2 Homo sapiens 187-192 22213773-5 2012 In contrast, treatment with 9cisRA rapidly enhanced the production of monocyte chemoattractive protein/CCL2. 9cisra 28-34 C-C motif chemokine ligand 2 Homo sapiens 103-107 22013105-9 2012 The plasma concentrations of monocyte chemoattractant protein-1, matrix metalloproteinase-9, serum amyloid A, and IL-6 were suppressed after 12 wk exenatide treatment by 15 +- 7, 20 +- 11, 16 +- 7, and 22 +- 12%, respectively (P < 0.05 for all). Exenatide 147-156 C-C motif chemokine ligand 2 Homo sapiens 29-63 22124178-8 2012 In THP-1 cells, telmisartan significantly reduced LPS-induced tumor necrosis factor-alpha, inhibitor of kappaB-alpha, monocyte chemotactic protein-1 (MCP-1) and lectin-like oxidized low-density lipoprotein receptor-1 gene expression and MCP-1-directed migration. Telmisartan 16-27 C-C motif chemokine ligand 2 Homo sapiens 118-148 22124178-8 2012 In THP-1 cells, telmisartan significantly reduced LPS-induced tumor necrosis factor-alpha, inhibitor of kappaB-alpha, monocyte chemotactic protein-1 (MCP-1) and lectin-like oxidized low-density lipoprotein receptor-1 gene expression and MCP-1-directed migration. Telmisartan 16-27 C-C motif chemokine ligand 2 Homo sapiens 150-155 22124178-8 2012 In THP-1 cells, telmisartan significantly reduced LPS-induced tumor necrosis factor-alpha, inhibitor of kappaB-alpha, monocyte chemotactic protein-1 (MCP-1) and lectin-like oxidized low-density lipoprotein receptor-1 gene expression and MCP-1-directed migration. Telmisartan 16-27 C-C motif chemokine ligand 2 Homo sapiens 237-242 22736938-0 2012 Palmitate induced secretion of IL-6 and MCP-1 in orbital fibroblasts derived from patients with thyroid-associated ophthalmopathy. Palmitates 0-9 C-C motif chemokine ligand 2 Homo sapiens 40-45 23324306-6 2012 Here, we compared and monitored the effects of EGFR inhibitors gefitinib, erlotinib and AG1517 (PD153035) on the mRNA expression levels of Fosl1, Tnf and Ccl2. Gefitinib 69-78 C-C motif chemokine ligand 2 Homo sapiens 166-170 23324306-6 2012 Here, we compared and monitored the effects of EGFR inhibitors gefitinib, erlotinib and AG1517 (PD153035) on the mRNA expression levels of Fosl1, Tnf and Ccl2. Erlotinib Hydrochloride 80-89 C-C motif chemokine ligand 2 Homo sapiens 166-170 22496599-0 2012 Activation of peroxisome proliferator-activated receptor-gamma by glitazones reduces the expression and release of monocyte chemoattractant protein-1 in human mesothelial cells. Thiazolidinediones 66-76 C-C motif chemokine ligand 2 Homo sapiens 115-149 22496599-2 2012 The present study was designed to assess the effect of the peroxisome proliferator-activated receptor-gamma- (PPARgamma-) activator rosiglitazone on the mesothelial MCP-1 expression and release. Rosiglitazone 132-145 C-C motif chemokine ligand 2 Homo sapiens 165-170 22496599-7 2012 Activation of this receptor via rosiglitazone (0,1-10 mumol/L) resulted in significantly reduced amounts of mesothelial MCP-1 release as well as MCP-1 mRNA. Rosiglitazone 32-45 C-C motif chemokine ligand 2 Homo sapiens 120-125 22496599-7 2012 Activation of this receptor via rosiglitazone (0,1-10 mumol/L) resulted in significantly reduced amounts of mesothelial MCP-1 release as well as MCP-1 mRNA. Rosiglitazone 32-45 C-C motif chemokine ligand 2 Homo sapiens 145-150 22496599-9 2012 Rosiglitazone was also effective in reducing TNFalpha-induced enhanced secretion of MCP-1. Rosiglitazone 0-13 C-C motif chemokine ligand 2 Homo sapiens 84-89 22496599-10 2012 Our findings indicate that glitazones are effective in reducing constitutive and TNFalpha-stimulated mesothelial MCP-1 mRNA expression and release. Thiazolidinediones 27-37 C-C motif chemokine ligand 2 Homo sapiens 113-118 22777192-11 2012 CRP was similar after both therapies (8,8+-34 vs. 8,4+-32 microg/mL) but MCP-1 concentration was significantly lower after aliskiren than after ramipril (294,0+-172,6 vs. 358,9+-183,3 pg/mL). aliskiren 123-132 C-C motif chemokine ligand 2 Homo sapiens 73-78 22777192-14 2012 The decrease of MCP-1 concentration after aliskiren treatment may provide an indirect evidence for its blood pressure independent cardioprotective and anti-inflammatory effects. aliskiren 42-51 C-C motif chemokine ligand 2 Homo sapiens 16-21 22736938-13 2012 Treatment with palmitate induced significant production of IL-6 and MCP-1, but not IL-8 and HA, in orbital fibroblasts. Palmitates 15-24 C-C motif chemokine ligand 2 Homo sapiens 68-73 22736938-15 2012 IL-6 expression was mediated by the p38, ERK, JNK pathways, whereas MCP-1 expression was mediated by ERK and JNK, but not by p38, in palmitate-treated orbital fibroblasts. Palmitates 133-142 C-C motif chemokine ligand 2 Homo sapiens 68-73 22776897-6 2012 U937 human monocyte cell culture was used to examine the effect of AA and BHB on secretion of MCP-1. 3-Hydroxybutyric Acid 74-77 C-C motif chemokine ligand 2 Homo sapiens 94-99 22086172-2 2011 Here we describe the properties of an ABA synthetic analog that competes with the hormone for binding to human granulocyte membranes and to purified recombinant LANCL2 (the human ABA receptor) and inhibits several ABA-triggered inflammatory functions of granulocytes and monocytes in vitro: chemotaxis, phagocytosis, reactive oxygen species production and release of prostaglandin E(2) (PGE(2)) by human granulocytes, release of PGE(2) and of monocyte chemoattractant protein-1 by human monocytes. Abscisic Acid 38-41 C-C motif chemokine ligand 2 Homo sapiens 443-477 22973975-7 2012 Preincubation of Detroit cells with 200 muM curcumin for 5 to 60 min resulted in complete suppression of the release of tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, monocyte chemoattractant protein 1, granulocyte macrophage-colony stimulating factor, and vascular endothelial growth factor. Curcumin 44-52 C-C motif chemokine ligand 2 Homo sapiens 175-209 23028541-13 2012 Over 97% of PSS samples were distinguished from controls by elevated CXCL10 (>500 ng/mL), CXCL8 (>30 ng/mL) and CCL2 (>60 ng/mL) levels. pss 12-15 C-C motif chemokine ligand 2 Homo sapiens 118-122 22615566-5 2012 The structure reveals that the monomeric CCL2 adopts a beta-trefoil fold and recognizes the trisaccharide by a single, topologically novel carbohydrate-binding site. Trisaccharides 92-105 C-C motif chemokine ligand 2 Homo sapiens 41-45 22615566-5 2012 The structure reveals that the monomeric CCL2 adopts a beta-trefoil fold and recognizes the trisaccharide by a single, topologically novel carbohydrate-binding site. Carbohydrates 139-151 C-C motif chemokine ligand 2 Homo sapiens 41-45 22615566-8 2012 The trisaccharide specifically recognized by CCL2 is a key carbohydrate determinant of pollen and insect venom allergens implying this particular glycoepitope is targeted by both fungal defence and mammalian immune systems. Trisaccharides 4-17 C-C motif chemokine ligand 2 Homo sapiens 45-49 22615566-8 2012 The trisaccharide specifically recognized by CCL2 is a key carbohydrate determinant of pollen and insect venom allergens implying this particular glycoepitope is targeted by both fungal defence and mammalian immune systems. Carbohydrates 59-71 C-C motif chemokine ligand 2 Homo sapiens 45-49 21912093-8 2012 RESULTS: Analytes sensitive to dithiothreitol (DTT) that had increased recovery in the 2-step sputum process were IL-1beta, 4, 5, 10, 13, IFN-gamma, TNFRI, GM-CSF, CCL2, 3, 4, 5, 13 and 17. Dithiothreitol 31-45 C-C motif chemokine ligand 2 Homo sapiens 164-168 21912093-8 2012 RESULTS: Analytes sensitive to dithiothreitol (DTT) that had increased recovery in the 2-step sputum process were IL-1beta, 4, 5, 10, 13, IFN-gamma, TNFRI, GM-CSF, CCL2, 3, 4, 5, 13 and 17. Dithiothreitol 47-50 C-C motif chemokine ligand 2 Homo sapiens 164-168 23185512-4 2012 CCL2-mediated VCAM-1 expression was attenuated by CCR2 inhibitor (RS102895), PKCdelta inhibitor (rottlerin), p38MAPK inhibitor (SB203580), and AP-1 inhibitors (curcumin and tanshinone IIA). RS 102895 66-74 C-C motif chemokine ligand 2 Homo sapiens 0-4 23185512-4 2012 CCL2-mediated VCAM-1 expression was attenuated by CCR2 inhibitor (RS102895), PKCdelta inhibitor (rottlerin), p38MAPK inhibitor (SB203580), and AP-1 inhibitors (curcumin and tanshinone IIA). rottlerin 97-106 C-C motif chemokine ligand 2 Homo sapiens 0-4 23185512-4 2012 CCL2-mediated VCAM-1 expression was attenuated by CCR2 inhibitor (RS102895), PKCdelta inhibitor (rottlerin), p38MAPK inhibitor (SB203580), and AP-1 inhibitors (curcumin and tanshinone IIA). SB 203580 128-136 C-C motif chemokine ligand 2 Homo sapiens 0-4 23185512-4 2012 CCL2-mediated VCAM-1 expression was attenuated by CCR2 inhibitor (RS102895), PKCdelta inhibitor (rottlerin), p38MAPK inhibitor (SB203580), and AP-1 inhibitors (curcumin and tanshinone IIA). Curcumin 160-168 C-C motif chemokine ligand 2 Homo sapiens 0-4 23185512-4 2012 CCL2-mediated VCAM-1 expression was attenuated by CCR2 inhibitor (RS102895), PKCdelta inhibitor (rottlerin), p38MAPK inhibitor (SB203580), and AP-1 inhibitors (curcumin and tanshinone IIA). tanshinone 173-187 C-C motif chemokine ligand 2 Homo sapiens 0-4 22815786-6 2012 Atorvastatin increased the intracellular contents of GRO-alpha, IL-8, and MCP-1 and induced colocalization with E-selectin in multivesicular bodies. Atorvastatin 0-12 C-C motif chemokine ligand 2 Homo sapiens 74-79 22514713-4 2012 Our results show that artemisinin significantly inhibited LPS-induced production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1) and nitric oxide (NO). artemisinin 22-33 C-C motif chemokine ligand 2 Homo sapiens 147-177 22514713-4 2012 Our results show that artemisinin significantly inhibited LPS-induced production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1) and nitric oxide (NO). artemisinin 22-33 C-C motif chemokine ligand 2 Homo sapiens 179-184 22086172-2 2011 Here we describe the properties of an ABA synthetic analog that competes with the hormone for binding to human granulocyte membranes and to purified recombinant LANCL2 (the human ABA receptor) and inhibits several ABA-triggered inflammatory functions of granulocytes and monocytes in vitro: chemotaxis, phagocytosis, reactive oxygen species production and release of prostaglandin E(2) (PGE(2)) by human granulocytes, release of PGE(2) and of monocyte chemoattractant protein-1 by human monocytes. Abscisic Acid 179-182 C-C motif chemokine ligand 2 Homo sapiens 443-477 22241125-10 2011 In contrast, OHB patients showed an increase in monocyte chemoattractant protein (MCP)-1 and MCP-2 compared to healthy controls and patients who resolved HBV infection. salicylamide 13-16 C-C motif chemokine ligand 2 Homo sapiens 48-88 21957157-7 2011 In contrast, IPC in sham-operated control animals evoked a modest initial upregulation of VEGF (P = 0.01), MCP-1 (P = 0.02), and CXCL1 (P = 0.03) mRNA in the muscle without concomitant changes in protein levels. ipc 13-16 C-C motif chemokine ligand 2 Homo sapiens 107-112 22076814-3 2011 For example, CCL3 (MIP-1alpha), CCL4 (MIP-1beta) and CCL5 (RANTES) have been shown to possess antiviral effects by binding to the HIV-1 co-receptor CCR5, whereas CCL2, a pro-inflammatory chemokine, supports HIV-1 replication despite being a member of same chemokine family. Carbon Tetrachloride 32-36 C-C motif chemokine ligand 2 Homo sapiens 162-166 21956423-3 2011 OBJECTIVE: Our objective was to determine the effects of 10 wk of dietary fructose or glucose consumption on plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1), E-selectin, intercellular adhesion molecule-1, C-reactive protein, and IL-6. Glucose 86-93 C-C motif chemokine ligand 2 Homo sapiens 134-168 21956423-10 2011 CONCLUSIONS: Consumption of fructose for 10 wk leads to increases of MCP-1, PAI-1, and E-selectin. Fructose 28-36 C-C motif chemokine ligand 2 Homo sapiens 69-74 21877251-8 2011 Using oligonucleotide microarray, we demonstrated a dramatic increase in proinflammatory cytokine and chemokine transcripts (CXCL10, CXCL11, TNFSF10, CCL5, CCL4, CCL2, IFNB1, CCL20, IL-8, and CCL11). Oligonucleotides 6-21 C-C motif chemokine ligand 2 Homo sapiens 162-166 21855538-8 2011 Furthermore, MCP-1 serum levels were also elevated in patients with ultrasound-diagnosed NAFLD and correlated with the body-mass index and fasting glucose. Glucose 147-154 C-C motif chemokine ligand 2 Homo sapiens 13-18 21912264-7 2011 Furthermore, with the addition of the NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B) and extracellular signal-regulated kinase inhibitors pyrrolidine dithiocarbamate and PD98059, the IL-17-induced CCL2 mRNA level was significantly compromised. pyrrolidine dithiocarbamic acid 160-187 C-C motif chemokine ligand 2 Homo sapiens 219-223 21771657-3 2011 In this paper, we discuss the evidence that doxycycline and related non-antibiotic chemically modified tetracyclines (e.g., CMT-3) can effectively reduce cytokine (TNF-alpha, IL-6, and MCP-1) production by human mononuclear inflammatory cells when stimulated either by endotoxin (LPS) or by a complex of C-reactive protein/oxidized LDL cholesterol relevant to the pathogenesis of periodontal disease and ASCVD, respectively. Doxycycline 44-55 C-C motif chemokine ligand 2 Homo sapiens 185-190 21771657-3 2011 In this paper, we discuss the evidence that doxycycline and related non-antibiotic chemically modified tetracyclines (e.g., CMT-3) can effectively reduce cytokine (TNF-alpha, IL-6, and MCP-1) production by human mononuclear inflammatory cells when stimulated either by endotoxin (LPS) or by a complex of C-reactive protein/oxidized LDL cholesterol relevant to the pathogenesis of periodontal disease and ASCVD, respectively. Tetracyclines 103-116 C-C motif chemokine ligand 2 Homo sapiens 185-190 21906671-7 2011 Hyperoxia resulted in significant increases in cytotoxicity, ROS generation, and MCP-1 production, which were significantly attenuated with the functional activation of AhR by omeprazole. Omeprazole 176-186 C-C motif chemokine ligand 2 Homo sapiens 81-86 22087859-12 2011 Concerning MCP-1, the basal level is down-regulated by SR141716A, but not the LPS-induced level. Rimonabant 55-64 C-C motif chemokine ligand 2 Homo sapiens 11-16 21906671-9 2011 These findings support the hypothesis that omeprazole protects against hyperoxic injury in vitro via AhR activation that is associated with decreased ROS generation and expression of MCP-1. Omeprazole 43-53 C-C motif chemokine ligand 2 Homo sapiens 183-188 22033411-8 2011 The increase in MCP-1 expression was prevented by treatment with quinazoline or salicylate, inhibitors of nuclear factor-kappaB activation. Quinazolines 65-76 C-C motif chemokine ligand 2 Homo sapiens 16-21 22013115-6 2011 This shift was confined to the SVC fraction, in which secretion of Th1 cytokines (IL-6, MCP-1, and TNF-alpha) was blocked by DHA. Docosahexaenoic Acids 125-128 C-C motif chemokine ligand 2 Homo sapiens 88-93 21976775-9 2011 Finally, we found that DMF attenuates CCL2-induced monocyte chemotaxis, suggesting that DMF could decrease recruitment of activated monocytes to the CNS in response to inflammatory mediators. Dimethyl Fumarate 23-26 C-C motif chemokine ligand 2 Homo sapiens 38-42 21976775-9 2011 Finally, we found that DMF attenuates CCL2-induced monocyte chemotaxis, suggesting that DMF could decrease recruitment of activated monocytes to the CNS in response to inflammatory mediators. Dimethyl Fumarate 88-91 C-C motif chemokine ligand 2 Homo sapiens 38-42 22033411-8 2011 The increase in MCP-1 expression was prevented by treatment with quinazoline or salicylate, inhibitors of nuclear factor-kappaB activation. Salicylates 80-90 C-C motif chemokine ligand 2 Homo sapiens 16-21 21119093-5 2011 Bezafibrate treatment normalized monocyte release of MCP-1, interleukin-6, TNF-alpha, and interleukin-1beta and also normalized plasma hsCRP levels in mixed dyslipidemic subjects, whereas in IFG individuals the drug reduced only MCP-1 and interleukin-6 release. Bezafibrate 0-11 C-C motif chemokine ligand 2 Homo sapiens 53-58 21733322-0 2011 Reduction of monocyte chemoattractant protein 1 and macrophage migration inhibitory factor by a polyphenol-rich extract in subjects with clustered cardiometabolic risk factors. Polyphenols 96-106 C-C motif chemokine ligand 2 Homo sapiens 13-47 21878375-3 2011 Data showed that DMSO decreased induced IL-6 and MCP-1 secretions in a dose-dependent manner (P<0.05), but not IL-8; these effects were cell development- and stimulus- independent. Dimethyl Sulfoxide 17-21 C-C motif chemokine ligand 2 Homo sapiens 49-54 21782151-7 2011 RESULTS: Before the administration of the drugs, aqueous levels of IL-8, IP-10, MCP-1, and VEGF were significantly higher in the DME group than in the control group. dme 129-132 C-C motif chemokine ligand 2 Homo sapiens 80-85 21782151-9 2011 IL-6, IP-10, MCP-1, PDGF-AA, and VEGF were significantly decreased in the IVTA group, but only VEGF in the IVBe group. ivta 74-78 C-C motif chemokine ligand 2 Homo sapiens 13-18 21744268-0 2011 Synthetic peptide fragment (65-76) of monocyte chemotactic protein-1 (MCP-1) inhibits MCP-1 binding to heparin and possesses anti-inflammatory activity in stable angina patients after coronary stenting. Heparin 103-110 C-C motif chemokine ligand 2 Homo sapiens 38-68 21744268-0 2011 Synthetic peptide fragment (65-76) of monocyte chemotactic protein-1 (MCP-1) inhibits MCP-1 binding to heparin and possesses anti-inflammatory activity in stable angina patients after coronary stenting. Heparin 103-110 C-C motif chemokine ligand 2 Homo sapiens 70-75 21744268-0 2011 Synthetic peptide fragment (65-76) of monocyte chemotactic protein-1 (MCP-1) inhibits MCP-1 binding to heparin and possesses anti-inflammatory activity in stable angina patients after coronary stenting. Heparin 103-110 C-C motif chemokine ligand 2 Homo sapiens 86-91 21744268-9 2011 MCP-1 dimerization was studied by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Sodium Dodecyl Sulfate 34-56 C-C motif chemokine ligand 2 Homo sapiens 0-5 21744268-9 2011 MCP-1 dimerization was studied by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). polyacrylamide 57-71 C-C motif chemokine ligand 2 Homo sapiens 0-5 21744268-9 2011 MCP-1 dimerization was studied by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Sodium Dodecyl Sulfate 93-96 C-C motif chemokine ligand 2 Homo sapiens 0-5 21951854-4 2011 Treatment of HeLa cells with 5-aza-dC, an inhibitor of DNA methylation, abolished the repression of IL-1beta-induced MCP-1 expression by hypoxia. Decitabine 29-37 C-C motif chemokine ligand 2 Homo sapiens 117-122 21951854-8 2011 Our findings suggest that changes in the methylation status of CpGs, as well as histone 3 methylation, may represent a critical event in transcriptional repression of IL-1beta-induced MCP-1 expression by hypoxia. cytidylyl-3'-5'-guanosine 63-67 C-C motif chemokine ligand 2 Homo sapiens 184-189 21859809-1 2011 The cystine-cystine (CC) chemokine monocyte chemoattractant protein-1 (MCP-1) has been established playing a pathogenic role in the development of atherosclerosis due to its chemotactic ability of leading monocytes to locate to subendothelia. cystine-cystine 4-19 C-C motif chemokine ligand 2 Homo sapiens 35-69 21859809-1 2011 The cystine-cystine (CC) chemokine monocyte chemoattractant protein-1 (MCP-1) has been established playing a pathogenic role in the development of atherosclerosis due to its chemotactic ability of leading monocytes to locate to subendothelia. cystine-cystine 4-19 C-C motif chemokine ligand 2 Homo sapiens 71-76 21859809-4 2011 Moreover, MCP-1 upregulated p53 expression of HUVECs and the p53-specific inhibitor pifithrin-alpha (PFTalpha) rescued the MCP-1-induced apoptosis of HUVECs. pifithrin 84-99 C-C motif chemokine ligand 2 Homo sapiens 123-128 21859809-4 2011 Moreover, MCP-1 upregulated p53 expression of HUVECs and the p53-specific inhibitor pifithrin-alpha (PFTalpha) rescued the MCP-1-induced apoptosis of HUVECs. pifithrin 101-109 C-C motif chemokine ligand 2 Homo sapiens 123-128 21693690-6 2011 Stimulation of NOD1 with a synthetic ligand Tri-DAP induces proinflammatory chemokine MCP-1, RANTES, and cytokine TNF-alpha and MIP-2 (human IL-8 homolog) and IL-6 mRNA expression in 3T3-L1 adipocytes in a time- and dose-dependent manner. L-Ala-gamma-D-Glu-meso-diaminopimelic acid 44-51 C-C motif chemokine ligand 2 Homo sapiens 86-91 21119093-5 2011 Bezafibrate treatment normalized monocyte release of MCP-1, interleukin-6, TNF-alpha, and interleukin-1beta and also normalized plasma hsCRP levels in mixed dyslipidemic subjects, whereas in IFG individuals the drug reduced only MCP-1 and interleukin-6 release. Bezafibrate 0-11 C-C motif chemokine ligand 2 Homo sapiens 229-234 21744278-5 2011 SP600125 attenuated t10,c12 CLA-mediated induction of inflammatory genes, including interleukin (IL)-6, IL-8, IL-1beta, ATF3, monocyte chemoattractant protein (MCP)-1, and cyclooxygenase-2. pyrazolanthrone 0-8 C-C motif chemokine ligand 2 Homo sapiens 126-166 21812913-11 2011 In transwell assays, asTF potentiated PMBC migration through MVEC monolayers by ~3-fold under MCP-1 gradient. astf 21-25 C-C motif chemokine ligand 2 Homo sapiens 94-99 21744278-6 2011 Consistent with these data, SP600125 prevented t10,c12 CLA-mediated secretion of IL-8, IL-6, and MCP-1. pyrazolanthrone 28-36 C-C motif chemokine ligand 2 Homo sapiens 97-102 21708226-7 2011 Moreover, SMC treated with glycol-AGEs also expressed interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1), and the level of cytokines expression was significantly elevated in the co-culture system of HUVEC and THP-1 when treated with glycol-AGEs. Glycols 27-33 C-C motif chemokine ligand 2 Homo sapiens 79-113 21812913-11 2011 In transwell assays, asTF potentiated PMBC migration through MVEC monolayers by ~3-fold under MCP-1 gradient. pmbc 38-42 C-C motif chemokine ligand 2 Homo sapiens 94-99 21651980-2 2011 To investigate the mechanisms underlying the anti-atheroscleroic action of atorvastatin, we examined the expression of the receptor for advanced glycation end products (RAGE) and its downstream target gene, monocyte chemoattractant protein-1 (MCP-1) using real-time PCR. Atorvastatin 75-87 C-C motif chemokine ligand 2 Homo sapiens 207-241 21651980-6 2011 Treatment with atorvastatin (20mg/kg qd) significantly downregulated the expression of RAGE and MCP-1. Atorvastatin 15-27 C-C motif chemokine ligand 2 Homo sapiens 96-101 21930770-4 2011 Intratumoral RNS production induces CCL2 chemokine nitration and hinders T cell infiltration, resulting in the trapping of tumor-specific T cells in the stroma that surrounds cancer cells. Reactive Nitrogen Species 13-16 C-C motif chemokine ligand 2 Homo sapiens 36-40 21943001-10 2011 Finally, inhibition of either of these ROS-induced signaling pathways suppressed cytokine (TNF-alpha and IL-1beta) production, while chemokine (CCL2 and CXCL10) induction pathways were sensitive to inhibition of p38, but not ERK1/2 MAPK. Reactive Oxygen Species 39-42 C-C motif chemokine ligand 2 Homo sapiens 144-148 21460858-7 2011 Importantly, human alveolar macrophages showed enhanced LPS-induced FOSL1 and CCL2 expression after gefitinib treatment. Gefitinib 100-109 C-C motif chemokine ligand 2 Homo sapiens 78-82 21708226-7 2011 Moreover, SMC treated with glycol-AGEs also expressed interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1), and the level of cytokines expression was significantly elevated in the co-culture system of HUVEC and THP-1 when treated with glycol-AGEs. Glycols 27-33 C-C motif chemokine ligand 2 Homo sapiens 115-120 21114535-8 2011 Systemic treatment of the recipient with YSPSL pre-reperfusion, with or without pre-implantation YSPSL flush of the donor organ, attenuated the post-reperfusion increase in MCP-1 and TGFbeta (p < 0.05), E-selectin and hemoxygenase 1 transcripts (p < 0.1). yspsl 41-46 C-C motif chemokine ligand 2 Homo sapiens 173-190 21741938-0 2011 Mesenchymal stem cells stably transduced with a dominant-negative inhibitor of CCL2 greatly attenuate bleomycin-induced lung damage. Bleomycin 102-111 C-C motif chemokine ligand 2 Homo sapiens 79-83 21670067-5 2011 Nonreduced mCRP was largely inert in activating human coronary artery endothelial cells (HCAECs), whereas reduced or cysteine-mutated mCRP evoked marked release of IL-8 and monocyte chemoattractant protein-1 from HCAECs, with ~50% increase at a concentration of 1 mug/ml. Cysteine 117-125 C-C motif chemokine ligand 2 Homo sapiens 173-207 21601309-7 2011 The anti-oxidant molecule GSH shows a negative association with serum levels of MCP-1/CCL-2, RANTES/CCL5 and IP-10/CXCL-10 in SLE patients and with MCP-1/CCL-2 and RANTES/CCL5 in RA patients. Glutathione 26-29 C-C motif chemokine ligand 2 Homo sapiens 80-85 21940313-9 2011 CONCLUSIONS: Decreases in serum high sensitive CRP levels following calcium polycarbophil treatment may be involved in the relief of abdominal symptoms in IBS patients; diarrhea type IBS is characterized by increased MCP-1 expression. calcium polycarbophil 68-89 C-C motif chemokine ligand 2 Homo sapiens 217-222 21601309-7 2011 The anti-oxidant molecule GSH shows a negative association with serum levels of MCP-1/CCL-2, RANTES/CCL5 and IP-10/CXCL-10 in SLE patients and with MCP-1/CCL-2 and RANTES/CCL5 in RA patients. Glutathione 26-29 C-C motif chemokine ligand 2 Homo sapiens 86-91 21601309-7 2011 The anti-oxidant molecule GSH shows a negative association with serum levels of MCP-1/CCL-2, RANTES/CCL5 and IP-10/CXCL-10 in SLE patients and with MCP-1/CCL-2 and RANTES/CCL5 in RA patients. Glutathione 26-29 C-C motif chemokine ligand 2 Homo sapiens 148-153 21601309-7 2011 The anti-oxidant molecule GSH shows a negative association with serum levels of MCP-1/CCL-2, RANTES/CCL5 and IP-10/CXCL-10 in SLE patients and with MCP-1/CCL-2 and RANTES/CCL5 in RA patients. Glutathione 26-29 C-C motif chemokine ligand 2 Homo sapiens 154-159 21623862-4 2011 DA-6034 significantly inhibited NF-kappaB activation and upregulated the expressions of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 in MKN-45 cells infected with H. pylori. recoflavone 0-7 C-C motif chemokine ligand 2 Homo sapiens 113-147 21679760-6 2011 RESULTS: Sinomenine was found to significantly inhibit TNF-alpha induced cell surface expression of vascular cell adhesion molecule (VCAM)-1 and release of inflammatory cytokine and chemokine IL-6, CCL2 and CXCL8 from both normal and RA-FLS (all p<0.05). sinomenine 9-19 C-C motif chemokine ligand 2 Homo sapiens 198-202 21685244-8 2011 Our study has demonstrated for the first time that the abnormal lower CD82 expression in ESCs induced by TCDD and estrogen may be an important molecular basis of endometriosis pathogenesis through enhancing the CCL2 secretion and CCR2 expression and the invasion of ESCs via MAPK and integrinbeta1 signal pathway. Polychlorinated Dibenzodioxins 105-109 C-C motif chemokine ligand 2 Homo sapiens 211-215 21685244-7 2011 The combination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with 17beta-estradiol can promote the invasion of ESCs via suppressing CD82 expression and stimulating CCL2 secretion and CCR2 expression, and the enhanced interaction of CCL2-CCR2 recruits more macrophages into the ectopic milieu in a paracrine manner, which further downregulates CD82 expression in the ectopic ESCs. Polychlorinated Dibenzodioxins 19-54 C-C motif chemokine ligand 2 Homo sapiens 165-169 21685244-7 2011 The combination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with 17beta-estradiol can promote the invasion of ESCs via suppressing CD82 expression and stimulating CCL2 secretion and CCR2 expression, and the enhanced interaction of CCL2-CCR2 recruits more macrophages into the ectopic milieu in a paracrine manner, which further downregulates CD82 expression in the ectopic ESCs. Polychlorinated Dibenzodioxins 19-54 C-C motif chemokine ligand 2 Homo sapiens 233-237 21685244-7 2011 The combination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with 17beta-estradiol can promote the invasion of ESCs via suppressing CD82 expression and stimulating CCL2 secretion and CCR2 expression, and the enhanced interaction of CCL2-CCR2 recruits more macrophages into the ectopic milieu in a paracrine manner, which further downregulates CD82 expression in the ectopic ESCs. Polychlorinated Dibenzodioxins 56-60 C-C motif chemokine ligand 2 Homo sapiens 165-169 21685244-7 2011 The combination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with 17beta-estradiol can promote the invasion of ESCs via suppressing CD82 expression and stimulating CCL2 secretion and CCR2 expression, and the enhanced interaction of CCL2-CCR2 recruits more macrophages into the ectopic milieu in a paracrine manner, which further downregulates CD82 expression in the ectopic ESCs. Polychlorinated Dibenzodioxins 56-60 C-C motif chemokine ligand 2 Homo sapiens 233-237 21685244-7 2011 The combination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with 17beta-estradiol can promote the invasion of ESCs via suppressing CD82 expression and stimulating CCL2 secretion and CCR2 expression, and the enhanced interaction of CCL2-CCR2 recruits more macrophages into the ectopic milieu in a paracrine manner, which further downregulates CD82 expression in the ectopic ESCs. Estradiol 67-83 C-C motif chemokine ligand 2 Homo sapiens 165-169 21799302-2 2011 Monocyte chemoattractant protein-1 (MCP-1), a member of the cysteine-cysteine family of chemokines, is one of the cytokines involved in the pathogenesis of atherosclerosis and is also known as cysteine-cysteine chemokine ligand 2 (CCL2). cysteine-cysteine 60-77 C-C motif chemokine ligand 2 Homo sapiens 0-34 21685244-7 2011 The combination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) with 17beta-estradiol can promote the invasion of ESCs via suppressing CD82 expression and stimulating CCL2 secretion and CCR2 expression, and the enhanced interaction of CCL2-CCR2 recruits more macrophages into the ectopic milieu in a paracrine manner, which further downregulates CD82 expression in the ectopic ESCs. Estradiol 67-83 C-C motif chemokine ligand 2 Homo sapiens 233-237 21651918-13 2011 Moreover, reduction in the levels of IL-6, IL-1Ra, MCP-1/CCL2 and IL-8/CXCL8 was observed in the presence of APE1 Glu allele in BM patients. Glutamic Acid 114-117 C-C motif chemokine ligand 2 Homo sapiens 51-56 21651918-13 2011 Moreover, reduction in the levels of IL-6, IL-1Ra, MCP-1/CCL2 and IL-8/CXCL8 was observed in the presence of APE1 Glu allele in BM patients. Glutamic Acid 114-117 C-C motif chemokine ligand 2 Homo sapiens 57-61 21715345-10 2011 A significant increase in expression levels of IL-6, TNF-alpha, IL-8, MCP-1, ICAM-1, and BFGF was observed after poly (I:C) RNA stimulation (P < 0.05). Poly I-C 113-123 C-C motif chemokine ligand 2 Homo sapiens 70-75 21490083-8 2011 In peritoneal macrophages, rosiglitazone down-regulated interferon-gamma-induced gene expression of cyclooxygenase-2 and inducible nitric oxide synthase and attenuated the chemotactic response to monocyte chemotactic protein-1. Rosiglitazone 27-40 C-C motif chemokine ligand 2 Homo sapiens 196-226 21626431-9 2011 Indeed, levosimendan increased cyclic guanosine monophosphate (cGMP) in human umbilical vein endothelial cells (HUVECs) and impaired the tumor necrosis factor-alpha (TNF-alpha)-induced inflammatory expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), cyclooxygenase-2 (COX-2), and monocyte chemotactic protein-1 (MCP-1). Simendan 8-20 C-C motif chemokine ligand 2 Homo sapiens 298-328 21626431-9 2011 Indeed, levosimendan increased cyclic guanosine monophosphate (cGMP) in human umbilical vein endothelial cells (HUVECs) and impaired the tumor necrosis factor-alpha (TNF-alpha)-induced inflammatory expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), cyclooxygenase-2 (COX-2), and monocyte chemotactic protein-1 (MCP-1). Simendan 8-20 C-C motif chemokine ligand 2 Homo sapiens 330-335 21799302-2 2011 Monocyte chemoattractant protein-1 (MCP-1), a member of the cysteine-cysteine family of chemokines, is one of the cytokines involved in the pathogenesis of atherosclerosis and is also known as cysteine-cysteine chemokine ligand 2 (CCL2). cysteine-cysteine 60-77 C-C motif chemokine ligand 2 Homo sapiens 36-41 21799302-2 2011 Monocyte chemoattractant protein-1 (MCP-1), a member of the cysteine-cysteine family of chemokines, is one of the cytokines involved in the pathogenesis of atherosclerosis and is also known as cysteine-cysteine chemokine ligand 2 (CCL2). cysteine-cysteine 60-77 C-C motif chemokine ligand 2 Homo sapiens 193-229 21447688-7 2011 RESULTS: MCP-1-activated human monocytes increased [Ca(2+)](i), ROS levels, and apoptosis in RPE cells, all of which were inhibited by 8-bromo-cyclic adenosine diphosphoribosyl ribose (8-Br-cADPR), an antagonist of cADPR. Reactive Oxygen Species 64-67 C-C motif chemokine ligand 2 Homo sapiens 9-14 21447688-7 2011 RESULTS: MCP-1-activated human monocytes increased [Ca(2+)](i), ROS levels, and apoptosis in RPE cells, all of which were inhibited by 8-bromo-cyclic adenosine diphosphoribosyl ribose (8-Br-cADPR), an antagonist of cADPR. 8-bromo-cyclic adenosine diphosphoribosyl ribose 135-183 C-C motif chemokine ligand 2 Homo sapiens 9-14 21447688-7 2011 RESULTS: MCP-1-activated human monocytes increased [Ca(2+)](i), ROS levels, and apoptosis in RPE cells, all of which were inhibited by 8-bromo-cyclic adenosine diphosphoribosyl ribose (8-Br-cADPR), an antagonist of cADPR. 8-br-cadpr 185-195 C-C motif chemokine ligand 2 Homo sapiens 9-14 21610146-5 2011 RESULTS: CCR2b transduction led to CCL2-induced calcium flux and increased transmigration, as well as augmentation of in vitro T-cell killing ability. Calcium 48-55 C-C motif chemokine ligand 2 Homo sapiens 35-39 21756880-0 2011 Cilostazol reduces MCP-1-induced chemotaxis and adhesion of THP-1 monocytes by inhibiting CCR2 gene expression. Cilostazol 0-10 C-C motif chemokine ligand 2 Homo sapiens 19-24 21756880-3 2011 This study aimed to investigate the modulating effect of cilostazol on the MCP-1-induced chemotaxis and adhesion of monocytes. Cilostazol 57-67 C-C motif chemokine ligand 2 Homo sapiens 75-80 21756880-6 2011 Cilostazol dose-dependently inhibited the MCP-1-induced chemotaxis of monocytes which was shown to be cAMP-dependent. Cilostazol 0-10 C-C motif chemokine ligand 2 Homo sapiens 42-47 21756880-6 2011 Cilostazol dose-dependently inhibited the MCP-1-induced chemotaxis of monocytes which was shown to be cAMP-dependent. Cyclic AMP 102-106 C-C motif chemokine ligand 2 Homo sapiens 42-47 21756880-11 2011 Result confirmed the inhibitory effect of cilostazol on the phosphorylation of p44/42 and p38 MAPK after MCP-1 stimulation. Cilostazol 42-52 C-C motif chemokine ligand 2 Homo sapiens 105-110 21756880-12 2011 The activation of monocytes after MCP-1 treatment exhibited enhanced adhesion to vascular endothelial cells which was dose-dependently suppressed by cilostazol. Cilostazol 149-159 C-C motif chemokine ligand 2 Homo sapiens 34-39 21756880-13 2011 Together, cilostazol was demonstrated, for the first time, to inhibit the CCR2 gene expression and MCP-1-induced chemotaxis and adhesion of monocytes which might therefore reduce the infiltration of monocytes during the early atherosclerosis. Cilostazol 10-20 C-C motif chemokine ligand 2 Homo sapiens 99-104 21765609-0 2011 Relationship between dietary folate intake and plasma monocyte chemoattractant protein-1 and interleukin-8 in heart failure patients. Folic Acid 29-35 C-C motif chemokine ligand 2 Homo sapiens 54-88 21677137-6 2011 Activation of Nod1 by its agonist, bacterial gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP), in term trophoblast cultures induced a proinflammatory cytokine profile, characterized by elevated levels of secreted IL-6, GRO-alpha, and MCP-1, when compared with the control. N(2)-(gamma-D-glutamyl)-meso-2,2'-diaminopimelic acid 45-86 C-C motif chemokine ligand 2 Homo sapiens 236-241 21530057-10 2011 MCP-1 level was positively correlated with BMI (r=0.381, p=0.000), waist:hip ratio (r=0.421, p=0.000), HOMA-IR (r=0.265, p=0.007) and triglycerides (r=0.439, p=0.000). Triglycerides 134-147 C-C motif chemokine ligand 2 Homo sapiens 0-5 21508145-8 2011 Levothyroxine reduced monocyte release of TNF-alpha, IL-1beta, IL-6, and monocyte chemoattractant protein-1, whereas selenomethionine inhibited lymphocyte release of IL-2, interferon-gamma, and TNF-alpha, which was accompanied by a reduction in plasma CRP levels. Thyroxine 0-13 C-C motif chemokine ligand 2 Homo sapiens 73-107 21765609-7 2011 On the other hand, plasma levels of monocyte chemoattractant protein-1 significantly correlated with dietary folate intake (r = -0.31, p<0.001), and plasma interleukin-8 levels significantly correlated with dietary intakes of vitamin C (r = -0.38, p<0.001), beta-carotene (r = -0.42, p<0.001), and folate (r = -0.38, p<0.001) after the adjustment. Folic Acid 109-115 C-C motif chemokine ligand 2 Homo sapiens 36-70 21765609-8 2011 Dietary folate intake was found as a primary influencing factor on plasma levels of monocyte chemoattractant protein-1 (p<0.005, R(2) = 0.20) and interleukin-8 (p<0.001, R(2) = 0.32) through a stepwise multiple linear regression analysis. Folic Acid 8-14 C-C motif chemokine ligand 2 Homo sapiens 84-118 21765609-9 2011 Dietary folate intake was significantly associated with plasma levels of monocyte chemoattractant protein-1 and interleukin-8 which indicates dietary folate may have a potentially beneficial role in the prevention and treatment of heart failure. Folic Acid 8-14 C-C motif chemokine ligand 2 Homo sapiens 73-107 21765609-9 2011 Dietary folate intake was significantly associated with plasma levels of monocyte chemoattractant protein-1 and interleukin-8 which indicates dietary folate may have a potentially beneficial role in the prevention and treatment of heart failure. Folic Acid 150-156 C-C motif chemokine ligand 2 Homo sapiens 73-107 20952175-6 2011 In both preadipocytes and differentiated 3T3-L1 adipocytes, lycopene preincubation for 24 h decreased the TNFalpha-mediated induction of IL-6 and MCP-1. Lycopene 60-68 C-C motif chemokine ligand 2 Homo sapiens 146-151 21621513-6 2011 Furthermore, pretreatment with casuarinin decreased TNF-alpha-induced pro-inflammatory mediators, such as IL-1beta, IL-6, IL-8, and MCP-1. casuarinin 31-41 C-C motif chemokine ligand 2 Homo sapiens 132-137 21829352-7 2011 Conversely, females administered high doses of estradiol had a >=10-fold lower induction of TNF-alpha and CCL2 in the lungs and increased rates of survival as compared with females that had either low or no estradiol. Estradiol 47-56 C-C motif chemokine ligand 2 Homo sapiens 109-113 21330342-6 2011 Patients with pSS had higher levels CXCL10 and CCL2 than controls (P = 0.05). pss 14-17 C-C motif chemokine ligand 2 Homo sapiens 47-51 20803229-0 2011 Vardenafil, an inhibitor of phosphodiesterase-5, blocks advanced glycation end product (AGE)-induced up-regulation of monocyte chemoattractant protein-1 mRNA levels in endothelial cells by suppressing AGE receptor (RAGE) expression via elevation of cGMP. Vardenafil Dihydrochloride 0-10 C-C motif chemokine ligand 2 Homo sapiens 118-152 21575596-0 2011 Irbesartan attenuates ischemic brain damage by inhibition of MCP-1/CCR2 signaling pathway beyond AT1 receptor blockade. Irbesartan 0-10 C-C motif chemokine ligand 2 Homo sapiens 61-66 21575596-3 2011 Irbesartan is reported to act as an antagonist of the monocyte chemoattractant protein-1 (MCP-1) receptor, C-C chemokine receptor 2 (CCR2), due to its molecular structure. Irbesartan 0-10 C-C motif chemokine ligand 2 Homo sapiens 54-88 21575596-8 2011 MCP-1 mRNA level was significantly increased on the ipsilateral side after MCAO, and administration of irbesartan with propagermanium decreased the MCP-1 level, whereas co-administration of losartan did not. Irbesartan 103-113 C-C motif chemokine ligand 2 Homo sapiens 148-153 21575596-12 2011 Taking these findings together, irbesartan exerts more beneficial effects on ischemic brain damage with an MCP-1 receptor blocker, at least due to its inhibitory effects on MCP-1/CCR2 signaling beyond AT(1) receptor blockade. Irbesartan 32-42 C-C motif chemokine ligand 2 Homo sapiens 107-112 21411099-5 2011 The angiotensin converting enzyme (ACE) inhibitors, imidaprilat and perindoprilat, enhanced the secretion of endogenous HGF, augmented the TNF-alpha-induced IL-10 secretion and suppressed MCP-1 secretion from AAA tissue. imidaprilat 52-63 C-C motif chemokine ligand 2 Homo sapiens 188-193 21411099-5 2011 The angiotensin converting enzyme (ACE) inhibitors, imidaprilat and perindoprilat, enhanced the secretion of endogenous HGF, augmented the TNF-alpha-induced IL-10 secretion and suppressed MCP-1 secretion from AAA tissue. perindoprilat 68-81 C-C motif chemokine ligand 2 Homo sapiens 188-193 20803229-0 2011 Vardenafil, an inhibitor of phosphodiesterase-5, blocks advanced glycation end product (AGE)-induced up-regulation of monocyte chemoattractant protein-1 mRNA levels in endothelial cells by suppressing AGE receptor (RAGE) expression via elevation of cGMP. Cyclic GMP 249-253 C-C motif chemokine ligand 2 Homo sapiens 118-152 20803229-8 2011 Further, vardenafil reduced the AGE-induced ROS generation and subsequently inhibited up-regulation of monocyte chemoattractant protein-1 (MCP-1) mRNA levels in HUVEC. Vardenafil Dihydrochloride 9-19 C-C motif chemokine ligand 2 Homo sapiens 103-137 20803229-8 2011 Further, vardenafil reduced the AGE-induced ROS generation and subsequently inhibited up-regulation of monocyte chemoattractant protein-1 (MCP-1) mRNA levels in HUVEC. Vardenafil Dihydrochloride 9-19 C-C motif chemokine ligand 2 Homo sapiens 139-144 20803229-9 2011 We demonstrated here for the first time that vardenafil could block the AGE-induced up-regulation of MCP-1 mRNA levels in HUVEC by suppressing RAGE expression and subsequent ROS generation via elevation of cGMP. Vardenafil Dihydrochloride 45-55 C-C motif chemokine ligand 2 Homo sapiens 101-106 20803229-9 2011 We demonstrated here for the first time that vardenafil could block the AGE-induced up-regulation of MCP-1 mRNA levels in HUVEC by suppressing RAGE expression and subsequent ROS generation via elevation of cGMP. Reactive Oxygen Species 174-177 C-C motif chemokine ligand 2 Homo sapiens 101-106 20803229-9 2011 We demonstrated here for the first time that vardenafil could block the AGE-induced up-regulation of MCP-1 mRNA levels in HUVEC by suppressing RAGE expression and subsequent ROS generation via elevation of cGMP. Cyclic GMP 206-210 C-C motif chemokine ligand 2 Homo sapiens 101-106 21104588-11 2011 LPS-induced CCL2 concentration was significantly and positively correlated with serum triglyceride concentration (r=0.4; p=0.009) in T2D patients. Triglycerides 86-98 C-C motif chemokine ligand 2 Homo sapiens 12-16 21413027-3 2011 Here, we investigated the role of phosphatidylcholine-specific phospholipase C (PC-PLC) in LPS-induced IL-8 and MCP-1 production in VECs. Phosphatidylcholines 34-53 C-C motif chemokine ligand 2 Homo sapiens 112-117 21436722-6 2011 Increases in monocyte chemoattractant protein-1 and intercellular adhesion molecule 1 expression induced by ox-LDL, however, were inhibited by both ginkgolide B and CV3988. ginkgolide B 148-160 C-C motif chemokine ligand 2 Homo sapiens 13-47 21436722-6 2011 Increases in monocyte chemoattractant protein-1 and intercellular adhesion molecule 1 expression induced by ox-LDL, however, were inhibited by both ginkgolide B and CV3988. CV 3988 165-171 C-C motif chemokine ligand 2 Homo sapiens 13-47 21419119-0 2011 Extracellular HIV-1 Tat upregulates TNF-alpha dependent MCP-1/CCL2 production via activation of ERK1/2 pathway in rat hippocampal slice cultures: inhibition by resveratrol, a polyphenolic phytostilbene. Resveratrol 160-171 C-C motif chemokine ligand 2 Homo sapiens 56-61 21419119-4 2011 We also attempted to identify the mechanism by which resveratrol (trans-3,5,4"-trihydroxystilbene) modulates MCP-1 release in hippocampal tissues exposed to Tat. Resveratrol 53-64 C-C motif chemokine ligand 2 Homo sapiens 109-114 21419119-4 2011 We also attempted to identify the mechanism by which resveratrol (trans-3,5,4"-trihydroxystilbene) modulates MCP-1 release in hippocampal tissues exposed to Tat. trans-3,5,4"-trihydroxystilbene 66-97 C-C motif chemokine ligand 2 Homo sapiens 109-114 21419119-7 2011 Tat-induced MCP-1 release was abrogated by inhibitors of tyrosine kinases (TK), herbimycin A or genistein, a finding that supports the MAPK signaling mechanism. herbimycin 80-92 C-C motif chemokine ligand 2 Homo sapiens 12-17 21419119-7 2011 Tat-induced MCP-1 release was abrogated by inhibitors of tyrosine kinases (TK), herbimycin A or genistein, a finding that supports the MAPK signaling mechanism. Genistein 96-105 C-C motif chemokine ligand 2 Homo sapiens 12-17 21419119-12 2011 Additionally, the inhibition of Tat-induced production of MCP-1 and TNF-alpha via the inactivation of the ERK1/2 pathway may represent the anti-inflammatory mechanism of resveratrol in the hippocampus. Resveratrol 170-181 C-C motif chemokine ligand 2 Homo sapiens 58-63 21508136-8 2011 MCP-1 was positively associated with osteocalcin and propeptide of type 1 collagen in the leaner (r > 0.3, P < 0.05) but not the obese women and was not associated with BMD in either group. propeptide 53-63 C-C motif chemokine ligand 2 Homo sapiens 0-5 21413027-5 2011 Blocking the function of PC-PLC by exploiting the neutralization antibody of PC-PLC or tricyclodecan-9-yl-xanthogenate (D609), an inhibitor of PC-PLC, significantly inhibited LPS-induced production of IL-8 and MCP-1 in HUVECs. tricyclodecan-9-yl-xanthogenate 87-118 C-C motif chemokine ligand 2 Homo sapiens 210-215 21413027-5 2011 Blocking the function of PC-PLC by exploiting the neutralization antibody of PC-PLC or tricyclodecan-9-yl-xanthogenate (D609), an inhibitor of PC-PLC, significantly inhibited LPS-induced production of IL-8 and MCP-1 in HUVECs. tricyclodecane-9-yl-xanthogenate 120-124 C-C motif chemokine ligand 2 Homo sapiens 210-215 21296829-0 2011 Suppression of choroidal neovascularization and quantitative and qualitative inhibition of VEGF and CCL2 by heparin. Heparin 108-115 C-C motif chemokine ligand 2 Homo sapiens 100-104 21401388-3 2011 CS activates epithelial cells to secrete chemokines such as interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) that recruit neutrophils and macrophages to the lung. Cesium 0-2 C-C motif chemokine ligand 2 Homo sapiens 85-115 21401388-3 2011 CS activates epithelial cells to secrete chemokines such as interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) that recruit neutrophils and macrophages to the lung. Cesium 0-2 C-C motif chemokine ligand 2 Homo sapiens 117-122 21401388-9 2011 Production of both chemokines was significantly reduced with SFN given prior to CSE; SFN inhibited IL-8 and MCP-1 gene expression at the transcription level. sulforaphane 61-64 C-C motif chemokine ligand 2 Homo sapiens 108-113 21401388-9 2011 Production of both chemokines was significantly reduced with SFN given prior to CSE; SFN inhibited IL-8 and MCP-1 gene expression at the transcription level. sulforaphane 85-88 C-C motif chemokine ligand 2 Homo sapiens 108-113 21397653-8 2011 Taken together, CDP inhibits UVB-induced MMP-1 expression in skin fibroblasts by suppressing expression of AP-1 and CYR61 and MCP-1 production. Cytidine Diphosphate 16-19 C-C motif chemokine ligand 2 Homo sapiens 126-131 21924076-0 2011 [Effect of atorvastatin on advanced glycation end products induced monocyte chemoattractant protein-1 expression in cultured human endothelial cells]. Atorvastatin 11-23 C-C motif chemokine ligand 2 Homo sapiens 67-101 21924076-1 2011 OBJECTIVE: To investigate the effects of atorvastatin on advanced glycation end products (AGE) induced monocyte chemoattractant protein-1 (MCP-1) expression in human umbilical vein endothelial cells (HUVECs) and whether this effect could be linked to peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and nuclear factor-kappaB (NF-kappaB). Atorvastatin 41-53 C-C motif chemokine ligand 2 Homo sapiens 103-137 21924076-1 2011 OBJECTIVE: To investigate the effects of atorvastatin on advanced glycation end products (AGE) induced monocyte chemoattractant protein-1 (MCP-1) expression in human umbilical vein endothelial cells (HUVECs) and whether this effect could be linked to peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and nuclear factor-kappaB (NF-kappaB). Atorvastatin 41-53 C-C motif chemokine ligand 2 Homo sapiens 139-144 21924076-4 2011 RESULTS: (1) The expression of MCP-1 mRNA was increased in proportion with increasing concentrations of AGEs which could be blocked by atorvastatin in a dose-dependent manner. Atorvastatin 135-147 C-C motif chemokine ligand 2 Homo sapiens 31-36 21924076-7 2011 (4) PPAR-gamma inhibitor antagonized the effect of atorvastatin on the expression of phospho-NF-kappaB p65 protein, nonphospho-NF-kappaB p65 protein and MCP-1 mRNA stimulated by AGE in HUVECs (P < 0.01). Atorvastatin 51-63 C-C motif chemokine ligand 2 Homo sapiens 153-158 21397653-6 2011 CDP (10 or 5mg/ml) diminished UVB-induced MMP-1 and CYR61 mRNA expression and MCP-1 production, whereas, UVB-suppressed procollagen and TbRII mRNA was restored by CDP treatment. Cytidine Diphosphate 0-3 C-C motif chemokine ligand 2 Homo sapiens 78-83 21296829-9 2011 Relative decreases in VEGF and CCL2 levels were observed in media of ARPE19 cells at higher heparin concentrations. Heparin 92-99 C-C motif chemokine ligand 2 Homo sapiens 31-35 21296829-12 2011 Reduced VEGF and CCL2 secretion by RPE cells and suppression of VEGF-VEGFR2 and CCL2-CCR2 interactions at the laser site mediated by heparin may contribute to the pharmacologic effect. Heparin 133-140 C-C motif chemokine ligand 2 Homo sapiens 80-84 21367918-13 2011 Imatinib also inhibited the albumin-induced mRNA expression of MCP-1, VCAM-1, transforming growth factor (TGF)-beta1, and collagen I (alpha1). Imatinib Mesylate 0-8 C-C motif chemokine ligand 2 Homo sapiens 63-68 21320071-8 2011 MCP-1 (monocyte chemotactic protein 1) secretion increased in cells exposed to Mb-insult and this was abrogated by DFOB or DFOB-AdAOH. Deferoxamine 115-119 C-C motif chemokine ligand 2 Homo sapiens 0-5 21320071-8 2011 MCP-1 (monocyte chemotactic protein 1) secretion increased in cells exposed to Mb-insult and this was abrogated by DFOB or DFOB-AdAOH. Deferoxamine 115-119 C-C motif chemokine ligand 2 Homo sapiens 7-37 21320071-8 2011 MCP-1 (monocyte chemotactic protein 1) secretion increased in cells exposed to Mb-insult and this was abrogated by DFOB or DFOB-AdAOH. Deferoxamine 123-127 C-C motif chemokine ligand 2 Homo sapiens 0-5 21320071-8 2011 MCP-1 (monocyte chemotactic protein 1) secretion increased in cells exposed to Mb-insult and this was abrogated by DFOB or DFOB-AdAOH. adaoh 128-133 C-C motif chemokine ligand 2 Homo sapiens 0-5 21320071-8 2011 MCP-1 (monocyte chemotactic protein 1) secretion increased in cells exposed to Mb-insult and this was abrogated by DFOB or DFOB-AdAOH. adaoh 128-133 C-C motif chemokine ligand 2 Homo sapiens 7-37 21670915-8 2011 In addition, inhibition of nuclear factor kappaB by carbobenzoxyl-l-leucinyl-l-leucinyl-l-leucinal suppressed the secretion of interleukin-6 and monocyte chemoattractant protein-1 in the supernatants of S. aureus-infected human osteoblasts in a dose-dependent manner. carbobenzoxyl 52-65 C-C motif chemokine ligand 2 Homo sapiens 145-179 21349590-6 2011 CCL2 and CCL3 were significantly down-regulated 24h post infection with NY03 and Ab4. ny03 72-76 C-C motif chemokine ligand 2 Homo sapiens 0-4 21411606-8 2011 Vitamin A-supplemented, GII-infected children had reduced MCP-1 and TNFalpha levels compared with GII-infected children in the placebo group (P-interaction = 0.02 and 0.03, respectively). Vitamin A 0-9 C-C motif chemokine ligand 2 Homo sapiens 58-63 21486440-0 2011 Inflammatory mediators in breast cancer: coordinated expression of TNFalpha & IL-1beta with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition. Adenosine Monophosphate 77-80 C-C motif chemokine ligand 2 Homo sapiens 96-100 21486440-6 2011 Significant associations were found between CCL2 & CCL5 and TNFalpha & IL-1beta in the tumor cells in DCIS and IDC-no-relapse patients. Adenosine Monophosphate 50-53 C-C motif chemokine ligand 2 Homo sapiens 44-48 21486440-7 2011 In the IDC-with-relapse group, the expression of CCL2 & CCL5 was accompanied by further elevated incidence of TNFalpha & IL-1beta expression. Adenosine Monophosphate 55-58 C-C motif chemokine ligand 2 Homo sapiens 49-53 21486440-7 2011 In the IDC-with-relapse group, the expression of CCL2 & CCL5 was accompanied by further elevated incidence of TNFalpha & IL-1beta expression. Adenosine Monophosphate 124-127 C-C motif chemokine ligand 2 Homo sapiens 49-53 21276586-5 2011 Simvastatin and fenofibrate decreased monocyte release of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and monocyte chemoattractant protein-1 and lymphocyte release of interleukin-2, interferon-gamma, and tumor necrosis factor-alpha, which was accompanied by a decrease in plasma C-reactive protein levels. Simvastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 125-159 21276586-5 2011 Simvastatin and fenofibrate decreased monocyte release of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and monocyte chemoattractant protein-1 and lymphocyte release of interleukin-2, interferon-gamma, and tumor necrosis factor-alpha, which was accompanied by a decrease in plasma C-reactive protein levels. Fenofibrate 16-27 C-C motif chemokine ligand 2 Homo sapiens 125-159 20890983-7 2011 In SLE, neopterin was significantly correlated with higher erythrocyte sedimentation rate (ESR; P=0.001), tumor necrosis factor alpha (P<0.001), monocyte chemoattractant protein 1 (P=0.005), and homocysteine concentrations (P=0.01), but in RA, it was only associated with ESR (P=0.01). Neopterin 8-17 C-C motif chemokine ligand 2 Homo sapiens 148-182 21442636-0 2011 Circulating levels of MCP-1, sIL-2R, IL-15, and IL-8 predict anemia response to pomalidomide therapy in myelofibrosis. pomalidomide 80-92 C-C motif chemokine ligand 2 Homo sapiens 22-27 24900329-2 2011 INCB3284 exhibited an IC50 of 3.7 nM in antagonism of monocyte chemoattractant protein-1 binding to hCCR2, an IC50 of 4.7 nM in antagonism of chemotaxis activity, an IC50 of 84 muM in inhibition of the hERG potassium current, a free fraction of 58% in protein binding, high selectivity over other chemokine receptors and G-protein-coupled receptors, and acceptable oral bioavailability in rodents and primates. INCB 3284 0-8 C-C motif chemokine ligand 2 Homo sapiens 54-88 21112921-9 2011 RESULTS: After a 4-week TLM program, MCP-1, fasting insulin, and HOMA were significantly decreased in the TLM group compared to those in the control group (all p < .05). thiolactomycin 24-27 C-C motif chemokine ligand 2 Homo sapiens 37-42 21368227-0 2011 Sphingosylphosphorylcholine stimulates CCL2 production from human umbilical vein endothelial cells. sphingosine phosphorylcholine 0-27 C-C motif chemokine ligand 2 Homo sapiens 39-43 21455109-7 2011 Sulodexide partially prevents oxidative stress and totally eliminates other senescence-related changes such as increased release of MCP-1, lengthening of the population doubling time, and impaired healing of the cellular monolayer after its mechanical injury. glucuronyl glucosamine glycan sulfate 0-10 C-C motif chemokine ligand 2 Homo sapiens 132-137 21147091-4 2011 In this study, LPS treatment led to a marked upregulation of the levels of IL-1beta, IL-18, TNF-alpha, TGF-beta1, CCL2, CCL3, and CCL5 in HRMCs. hrmcs 138-143 C-C motif chemokine ligand 2 Homo sapiens 114-118 21256188-8 2011 The presence of alpha-tocopherol also modulated the expression of some cytokines, including CCL2, CCL3, IL-6, CSF3 and CXCL1; increased the antigen loading in monocytes; and increased the recruitment of granulocytes in the dLNs. alpha-Tocopherol 16-32 C-C motif chemokine ligand 2 Homo sapiens 92-96 21130860-10 2011 CR extract alone inhibited monocyte chemoattractant protein (MCP)-1 release and in the presence of LPS, inhibited IL-10, TNF-alpha and MCP-1 release compared to LPS alone. Chromium 0-2 C-C motif chemokine ligand 2 Homo sapiens 27-67 21130860-10 2011 CR extract alone inhibited monocyte chemoattractant protein (MCP)-1 release and in the presence of LPS, inhibited IL-10, TNF-alpha and MCP-1 release compared to LPS alone. Chromium 0-2 C-C motif chemokine ligand 2 Homo sapiens 135-140 21189358-6 2011 Dex suppressed genes in immune/inflammatory (IL-6, IL-8, and MCP-1, expressed in nonadipocytes) and proapoptotic pathways, yet induced genes related to the acute-phase response (SAA, factor D, haptoglobin, and RBP4, expressed in adipocytes) and stress/defense response. Dexamethasone 0-3 C-C motif chemokine ligand 2 Homo sapiens 61-66 21216561-5 2011 The results showed that atorvastatin significantly decreased the expression of six cytokines (IL-6, IL-8, IL-1, PAI-1, TGF-beta1, TGF-beta2) and five chemokines (CCL2, CCL7, CCL13, CCL18, CXCL1). Atorvastatin 24-36 C-C motif chemokine ligand 2 Homo sapiens 162-166 21317391-2 2011 In this study, we found that UDP induced expression of chemokines CCL2 (MCP-1) and CCL3 (MIP-1alpha) in microglia, astrocytes, and slice cultures by activation of P2Y(6). Uridine Diphosphate 29-32 C-C motif chemokine ligand 2 Homo sapiens 66-70 21317391-2 2011 In this study, we found that UDP induced expression of chemokines CCL2 (MCP-1) and CCL3 (MIP-1alpha) in microglia, astrocytes, and slice cultures by activation of P2Y(6). Uridine Diphosphate 29-32 C-C motif chemokine ligand 2 Homo sapiens 72-77 21317391-4 2011 However, CCL2 synthesis kinetics in response to UDP differed in microglia and astrocytes; microglia rapidly produced small amounts of CCL2, whereas astrocytes continuously synthesized large amounts of CCL2, resulting in a high ultimate level of the chemokine. Uridine Diphosphate 48-51 C-C motif chemokine ligand 2 Homo sapiens 9-13 21317391-4 2011 However, CCL2 synthesis kinetics in response to UDP differed in microglia and astrocytes; microglia rapidly produced small amounts of CCL2, whereas astrocytes continuously synthesized large amounts of CCL2, resulting in a high ultimate level of the chemokine. Uridine Diphosphate 48-51 C-C motif chemokine ligand 2 Homo sapiens 134-138 21317391-4 2011 However, CCL2 synthesis kinetics in response to UDP differed in microglia and astrocytes; microglia rapidly produced small amounts of CCL2, whereas astrocytes continuously synthesized large amounts of CCL2, resulting in a high ultimate level of the chemokine. Uridine Diphosphate 48-51 C-C motif chemokine ligand 2 Homo sapiens 134-138 21248183-6 2011 RESULTS: Vitamin A-supplemented children with fecal MCP-1 or IL-8 concentrations less than the median of detectable concentrations and IL-10 concentrations of at least median concentrations had longer durations of EPEC infection than did children in the placebo group. Vitamin A 9-18 C-C motif chemokine ligand 2 Homo sapiens 52-57 21183736-0 2011 Serum hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in patients with metabolic syndrome alterations. Iron 30-34 C-C motif chemokine ligand 2 Homo sapiens 50-55 21183736-3 2011 METHODS AND RESULTS: Manipulation of iron status with ferric ammonium citrate and hepcidin-25 induced monocyte chemoattractant protein (MCP)-1 and interleukin-6 in human differentiating monocytes of patients with hyperferritinemia associated with the metabolic syndrome (n=11), but not in subjects with hemochromatosis or HFE mutations impairing iron accumulation (n=15), and the degree of induction correlated with the presence of carotid plaques, detected by echocolor-Doppler. Iron 37-41 C-C motif chemokine ligand 2 Homo sapiens 102-142 21183736-3 2011 METHODS AND RESULTS: Manipulation of iron status with ferric ammonium citrate and hepcidin-25 induced monocyte chemoattractant protein (MCP)-1 and interleukin-6 in human differentiating monocytes of patients with hyperferritinemia associated with the metabolic syndrome (n=11), but not in subjects with hemochromatosis or HFE mutations impairing iron accumulation (n=15), and the degree of induction correlated with the presence of carotid plaques, detected by echocolor-Doppler. ferric ammonium citrate 54-77 C-C motif chemokine ligand 2 Homo sapiens 102-142 21183736-4 2011 In monocytes of healthy subjects (n=7), iron and hepcidin increased the mRNA levels and release of MCP-1, but not of interleukin-6. Iron 40-44 C-C motif chemokine ligand 2 Homo sapiens 99-104 21183736-6 2011 CONCLUSIONS: Hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in high-risk individuals with metabolic alterations. Iron 37-41 C-C motif chemokine ligand 2 Homo sapiens 57-62 22235409-0 2011 Changes in the concentration of monocytic chemotaxic protein-1 in patients with unstable angina treated with arixtra. Fondaparinux 109-116 C-C motif chemokine ligand 2 Homo sapiens 32-62 22235409-2 2011 Plasma concentration of monocytic chemotaxic protein-1 (MCP-1) decreased on days 2 and 3 in patients receiving arixtra and a trend to an increase in MCP-1 concentration was observed on day 7 after the drug was discontinued. Fondaparinux 111-118 C-C motif chemokine ligand 2 Homo sapiens 24-54 22235409-2 2011 Plasma concentration of monocytic chemotaxic protein-1 (MCP-1) decreased on days 2 and 3 in patients receiving arixtra and a trend to an increase in MCP-1 concentration was observed on day 7 after the drug was discontinued. Fondaparinux 111-118 C-C motif chemokine ligand 2 Homo sapiens 56-61 22235409-5 2011 It seems that arixtra is characterized by an anti-inflammatory effect manifesting by reduction of plasma chemokine MCP-1 concentration. Fondaparinux 14-21 C-C motif chemokine ligand 2 Homo sapiens 115-120 21386905-0 2011 Cigarette smoke-related hydroquinone dysregulates MCP-1, VEGF and PEDF expression in retinal pigment epithelium in vitro and in vivo. hydroquinone 24-36 C-C motif chemokine ligand 2 Homo sapiens 50-55 20932155-7 2011 SDD resulted in a stable IL-4 and IL-10 response while reducing the monocyte chemoattractant protein 1 levels at 3 months (P <0.05). 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt 0-3 C-C motif chemokine ligand 2 Homo sapiens 68-102 21348878-4 2011 Accordingly, this review examines how varying degrees of CR-induced weight loss (i.e., >10%, 5-10%, and <5% from baseline) impact plasma levels and expression of adiponectin, leptin, resistin, interleukin 6 (IL-6), interleukin 8 (IL-8), monocyte chemotactic protein 1 (MCP-1), and retinol-binding protein 4 (RBP-4). Chromium 57-59 C-C motif chemokine ligand 2 Homo sapiens 243-273 21348878-4 2011 Accordingly, this review examines how varying degrees of CR-induced weight loss (i.e., >10%, 5-10%, and <5% from baseline) impact plasma levels and expression of adiponectin, leptin, resistin, interleukin 6 (IL-6), interleukin 8 (IL-8), monocyte chemotactic protein 1 (MCP-1), and retinol-binding protein 4 (RBP-4). Chromium 57-59 C-C motif chemokine ligand 2 Homo sapiens 275-280 21386905-12 2011 CONCLUSION: We propose that impaired RPE-derived MCP-1-mediated scavenging macrophages recruitment and phagocytosis might lead to incomplete clearance of proinflammatory debris and infiltration of proangiogenic macrophages which along with increased VEGF/PEDF ratio favoring angiogenesis might promote drusen accumulation and progression to CNV in smoker patients with dry AMD. drusen 302-308 C-C motif chemokine ligand 2 Homo sapiens 49-54 20708308-10 2011 CONCLUSION: High consumption of total fat and dietary cholesterol accompanied by a low folate, antioxidant vitamin, a special vitamin C and dietary fiber intake, contributes to elevated Hcy, GGT and MCP-1 levels and in consequence, could lead to intense inflammatory process and atherosclerosis in HF patients. Cholesterol 54-65 C-C motif chemokine ligand 2 Homo sapiens 199-204 20708308-10 2011 CONCLUSION: High consumption of total fat and dietary cholesterol accompanied by a low folate, antioxidant vitamin, a special vitamin C and dietary fiber intake, contributes to elevated Hcy, GGT and MCP-1 levels and in consequence, could lead to intense inflammatory process and atherosclerosis in HF patients. Folic Acid 87-93 C-C motif chemokine ligand 2 Homo sapiens 199-204 21042828-0 2011 Renoprotective effects of clarithromycin via reduction of urinary MCP-1 levels in type 2 diabetic patients. Clarithromycin 26-40 C-C motif chemokine ligand 2 Homo sapiens 66-71 20952659-5 2011 Results show that NF-kappaB inhibitors prevent the induction of CCL2 expression in response to DAMGO administration and that the NF-kappaB subunit, p65, is phosphorylated at serine residues 311 and 536 in response to MOR activation. Serine 174-180 C-C motif chemokine ligand 2 Homo sapiens 64-68 21042828-7 2011 Urinary MCP-1 levels were significantly reduced in the clarithromycin-administrated group (P = 0.009). Clarithromycin 55-69 C-C motif chemokine ligand 2 Homo sapiens 8-13 21042828-10 2011 In the CAM group, the changes of serum creatinine also showed a significant positive correlation with those of urinary ACR, urinary MCP-1, urinary IL-18 and serum levels of soluble ICAM-1. Creatinine 39-49 C-C motif chemokine ligand 2 Homo sapiens 132-137 21042828-11 2011 CONCLUSION: The results from our study suggest that clarithromycin may attenuate the production of renal MCP-1 in type 2 diabetic patients, resulting in amelioration of urinary ACR via anti-inflammatory effects. Clarithromycin 52-66 C-C motif chemokine ligand 2 Homo sapiens 105-110 21156725-6 2011 PPACK, U0126, U-73122, 2-APB or GF-109203X suppressed the increases in production of IL-8, GROalpha and MCP-1 induced by thrombin (P < 0.001, P <0.001 and P <0.001, respectively). 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 14-21 C-C motif chemokine ligand 2 Homo sapiens 104-109 21156725-6 2011 PPACK, U0126, U-73122, 2-APB or GF-109203X suppressed the increases in production of IL-8, GROalpha and MCP-1 induced by thrombin (P < 0.001, P <0.001 and P <0.001, respectively). 2-aminoethoxydiphenyl borate 23-28 C-C motif chemokine ligand 2 Homo sapiens 104-109 21156725-6 2011 PPACK, U0126, U-73122, 2-APB or GF-109203X suppressed the increases in production of IL-8, GROalpha and MCP-1 induced by thrombin (P < 0.001, P <0.001 and P <0.001, respectively). glycylphenylalanine 32-34 C-C motif chemokine ligand 2 Homo sapiens 104-109 21156725-6 2011 PPACK, U0126, U-73122, 2-APB or GF-109203X suppressed the increases in production of IL-8, GROalpha and MCP-1 induced by thrombin (P < 0.001, P <0.001 and P <0.001, respectively). U 0126 7-12 C-C motif chemokine ligand 2 Homo sapiens 104-109 21073393-0 2011 Monocyte chemoattractant protein-1 is related to metabolic syndrome and homocysteine in subjects without clinically significant atherosclerotic cardiovascular disease. Homocysteine 72-84 C-C motif chemokine ligand 2 Homo sapiens 0-34 20663020-8 2011 RESULTS: Pretreatment of PBMCs with alendronate promoted lipid A-induced production of IL-1beta and IL-6, but decreased lipid A-induced IL-8 and MCP-1 production. Alendronate 36-47 C-C motif chemokine ligand 2 Homo sapiens 145-150 20663020-8 2011 RESULTS: Pretreatment of PBMCs with alendronate promoted lipid A-induced production of IL-1beta and IL-6, but decreased lipid A-induced IL-8 and MCP-1 production. Lipid A 120-127 C-C motif chemokine ligand 2 Homo sapiens 145-150 21461238-3 2011 Exposure of human AoSMCs to NAD(+), an agonist of the human P2Y(11) receptor, and NADP(+) as well as ATP, an agonist for P2Y(1) and P2Y(11) receptors, caused increase in chemokine (C-C motif) ligand 2 gene (CCL2) transcript and CCL2 release; however, UPT did not affect CCL2 expression. NADP 82-89 C-C motif chemokine ligand 2 Homo sapiens 170-200 21461238-3 2011 Exposure of human AoSMCs to NAD(+), an agonist of the human P2Y(11) receptor, and NADP(+) as well as ATP, an agonist for P2Y(1) and P2Y(11) receptors, caused increase in chemokine (C-C motif) ligand 2 gene (CCL2) transcript and CCL2 release; however, UPT did not affect CCL2 expression. NADP 82-89 C-C motif chemokine ligand 2 Homo sapiens 207-211 21461238-3 2011 Exposure of human AoSMCs to NAD(+), an agonist of the human P2Y(11) receptor, and NADP(+) as well as ATP, an agonist for P2Y(1) and P2Y(11) receptors, caused increase in chemokine (C-C motif) ligand 2 gene (CCL2) transcript and CCL2 release; however, UPT did not affect CCL2 expression. NADP 82-89 C-C motif chemokine ligand 2 Homo sapiens 228-232 21461238-3 2011 Exposure of human AoSMCs to NAD(+), an agonist of the human P2Y(11) receptor, and NADP(+) as well as ATP, an agonist for P2Y(1) and P2Y(11) receptors, caused increase in chemokine (C-C motif) ligand 2 gene (CCL2) transcript and CCL2 release; however, UPT did not affect CCL2 expression. NADP 82-89 C-C motif chemokine ligand 2 Homo sapiens 228-232 21461238-4 2011 CCL2 release by NAD(+) and NADP(+) was inhibited by a concentration dependent manner by suramin, an antagonist of P2-purinergic receptors. NAD 16-22 C-C motif chemokine ligand 2 Homo sapiens 0-4 21461238-4 2011 CCL2 release by NAD(+) and NADP(+) was inhibited by a concentration dependent manner by suramin, an antagonist of P2-purinergic receptors. NADP 27-34 C-C motif chemokine ligand 2 Homo sapiens 0-4 21461238-4 2011 CCL2 release by NAD(+) and NADP(+) was inhibited by a concentration dependent manner by suramin, an antagonist of P2-purinergic receptors. Suramin 88-95 C-C motif chemokine ligand 2 Homo sapiens 0-4 21461238-6 2011 NAD(+)- and NADP(+)-mediated CCL2 release was significantly attenuated by SP6001250, U0126, LY294002, Akt inhibitor IV, RO318220, GF109203X, and diphenyleneiodium chloride. NAD 0-6 C-C motif chemokine ligand 2 Homo sapiens 29-33 21461238-6 2011 NAD(+)- and NADP(+)-mediated CCL2 release was significantly attenuated by SP6001250, U0126, LY294002, Akt inhibitor IV, RO318220, GF109203X, and diphenyleneiodium chloride. NADP 12-19 C-C motif chemokine ligand 2 Homo sapiens 29-33 21461238-6 2011 NAD(+)- and NADP(+)-mediated CCL2 release was significantly attenuated by SP6001250, U0126, LY294002, Akt inhibitor IV, RO318220, GF109203X, and diphenyleneiodium chloride. sp6001250 74-83 C-C motif chemokine ligand 2 Homo sapiens 29-33 21461238-6 2011 NAD(+)- and NADP(+)-mediated CCL2 release was significantly attenuated by SP6001250, U0126, LY294002, Akt inhibitor IV, RO318220, GF109203X, and diphenyleneiodium chloride. U 0126 85-90 C-C motif chemokine ligand 2 Homo sapiens 29-33 21461238-6 2011 NAD(+)- and NADP(+)-mediated CCL2 release was significantly attenuated by SP6001250, U0126, LY294002, Akt inhibitor IV, RO318220, GF109203X, and diphenyleneiodium chloride. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 92-100 C-C motif chemokine ligand 2 Homo sapiens 29-33 21461238-6 2011 NAD(+)- and NADP(+)-mediated CCL2 release was significantly attenuated by SP6001250, U0126, LY294002, Akt inhibitor IV, RO318220, GF109203X, and diphenyleneiodium chloride. Ro 31-8220 120-128 C-C motif chemokine ligand 2 Homo sapiens 29-33 21461238-6 2011 NAD(+)- and NADP(+)-mediated CCL2 release was significantly attenuated by SP6001250, U0126, LY294002, Akt inhibitor IV, RO318220, GF109203X, and diphenyleneiodium chloride. bisindolylmaleimide I 130-139 C-C motif chemokine ligand 2 Homo sapiens 29-33 21461238-6 2011 NAD(+)- and NADP(+)-mediated CCL2 release was significantly attenuated by SP6001250, U0126, LY294002, Akt inhibitor IV, RO318220, GF109203X, and diphenyleneiodium chloride. diphenyleneiodonium 145-171 C-C motif chemokine ligand 2 Homo sapiens 29-33 21073393-7 2011 In multiple regression analysis, age, HOMA-IR and homocysteine were found to be an independent factor associated with MCP-1 adjusted by gender, waist, systolic blood pressure, triglyceride, HDL-cholesterol, and hs-CRP. Cholesterol 194-205 C-C motif chemokine ligand 2 Homo sapiens 118-123 21073393-6 2011 RESULTS: MCP-1 was positively correlated with homeostasis model assessment of insulin resistance, homocysteine, and mean pulse wave velocity, but IL-8 was not. Homocysteine 98-110 C-C motif chemokine ligand 2 Homo sapiens 9-14 21073393-7 2011 In multiple regression analysis, age, HOMA-IR and homocysteine were found to be an independent factor associated with MCP-1 adjusted by gender, waist, systolic blood pressure, triglyceride, HDL-cholesterol, and hs-CRP. Homocysteine 50-62 C-C motif chemokine ligand 2 Homo sapiens 118-123 21073393-7 2011 In multiple regression analysis, age, HOMA-IR and homocysteine were found to be an independent factor associated with MCP-1 adjusted by gender, waist, systolic blood pressure, triglyceride, HDL-cholesterol, and hs-CRP. Triglycerides 176-188 C-C motif chemokine ligand 2 Homo sapiens 118-123 21186817-5 2011 p-Coumaric acid, quercetin, and resveratrol demonstrated inhibitions of TNF-alpha-induced changes in levels of monocyte chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1), and intracellular reactive oxygen species (ROS) in 3T3-L1 adipocytes. p-coumaric acid 0-15 C-C motif chemokine ligand 2 Homo sapiens 111-145 21186817-5 2011 p-Coumaric acid, quercetin, and resveratrol demonstrated inhibitions of TNF-alpha-induced changes in levels of monocyte chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1), and intracellular reactive oxygen species (ROS) in 3T3-L1 adipocytes. p-coumaric acid 0-15 C-C motif chemokine ligand 2 Homo sapiens 147-152 21266029-7 2011 In ten SC patients receiving therapy with risperidone, olanzapine or clozapine basal and LPS-induced production of RANTES and IL-18 was increased, while both basal and LPS-induced MCP-1 production was decreased. Risperidone 42-53 C-C motif chemokine ligand 2 Homo sapiens 180-185 21266029-7 2011 In ten SC patients receiving therapy with risperidone, olanzapine or clozapine basal and LPS-induced production of RANTES and IL-18 was increased, while both basal and LPS-induced MCP-1 production was decreased. Clozapine 69-78 C-C motif chemokine ligand 2 Homo sapiens 180-185 21186817-5 2011 p-Coumaric acid, quercetin, and resveratrol demonstrated inhibitions of TNF-alpha-induced changes in levels of monocyte chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1), and intracellular reactive oxygen species (ROS) in 3T3-L1 adipocytes. Quercetin 17-26 C-C motif chemokine ligand 2 Homo sapiens 111-145 21186817-5 2011 p-Coumaric acid, quercetin, and resveratrol demonstrated inhibitions of TNF-alpha-induced changes in levels of monocyte chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1), and intracellular reactive oxygen species (ROS) in 3T3-L1 adipocytes. Quercetin 17-26 C-C motif chemokine ligand 2 Homo sapiens 147-152 21186817-5 2011 p-Coumaric acid, quercetin, and resveratrol demonstrated inhibitions of TNF-alpha-induced changes in levels of monocyte chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1), and intracellular reactive oxygen species (ROS) in 3T3-L1 adipocytes. Resveratrol 32-43 C-C motif chemokine ligand 2 Homo sapiens 111-145 21186817-5 2011 p-Coumaric acid, quercetin, and resveratrol demonstrated inhibitions of TNF-alpha-induced changes in levels of monocyte chemoattractant protein-1 (MCP-1), plasminogen activator inhibitor-1 (PAI-1), and intracellular reactive oxygen species (ROS) in 3T3-L1 adipocytes. Resveratrol 32-43 C-C motif chemokine ligand 2 Homo sapiens 147-152 21146687-0 2011 Differential effect of telmisartan and amlodipine on monocyte chemoattractant protein-1 and peroxisome proliferator-activated receptor-gamma gene expression in peripheral monocytes in patients with essential hypertension. Amlodipine 39-49 C-C motif chemokine ligand 2 Homo sapiens 53-87 20980255-7 2011 Furthermore, mTORC2 down-regulation decreased PGE(2)-induced production of the chemokine monocyte chemoattractant protein-1 (CCL2), which was linked to a significant reduction in ROS production. Dinoprostone 46-52 C-C motif chemokine ligand 2 Homo sapiens 125-129 20980255-7 2011 Furthermore, mTORC2 down-regulation decreased PGE(2)-induced production of the chemokine monocyte chemoattractant protein-1 (CCL2), which was linked to a significant reduction in ROS production. ros 179-182 C-C motif chemokine ligand 2 Homo sapiens 125-129 21148795-3 2011 Cell treatment with the potent GC budesonide accelerated the decay of CCL2 mRNA (t(1/2) = 8 +- 1 min versus 62 +- 17 min in DMSO-treated cells) and CCL7 mRNA (t(1/2) = 15 +- 4 min versus 114 +- 37 min), but not that of CCL5 mRNA (t(1/2)=231 +- 8 min versus 266 +- 5 min) in the BEAS-2B cell line. Budesonide 34-44 C-C motif chemokine ligand 2 Homo sapiens 70-74 21146687-8 2011 In contrast, in the amlodipine group, MCP-1 gene expression was significantly downregulated after treatment with telmisartan (from 21.4 +- 20.5 to 8.1 +- 6.5, p = 0.009), whereas the amlodipine group did not show any significant change (12.5 +- 8.5 vs 17.6 +- 16.4, p = NS). Amlodipine 20-30 C-C motif chemokine ligand 2 Homo sapiens 38-43 21146687-8 2011 In contrast, in the amlodipine group, MCP-1 gene expression was significantly downregulated after treatment with telmisartan (from 21.4 +- 20.5 to 8.1 +- 6.5, p = 0.009), whereas the amlodipine group did not show any significant change (12.5 +- 8.5 vs 17.6 +- 16.4, p = NS). Telmisartan 113-124 C-C motif chemokine ligand 2 Homo sapiens 38-43 21146687-8 2011 In contrast, in the amlodipine group, MCP-1 gene expression was significantly downregulated after treatment with telmisartan (from 21.4 +- 20.5 to 8.1 +- 6.5, p = 0.009), whereas the amlodipine group did not show any significant change (12.5 +- 8.5 vs 17.6 +- 16.4, p = NS). Amlodipine 183-193 C-C motif chemokine ligand 2 Homo sapiens 38-43 21146687-10 2011 In conclusion, treatment with telmisartan results in a significant attenuation of MCP-1 gene expression and an increase of PPAR-gamma gene expression in peripheral monocytes in patients with essential hypertension. Telmisartan 30-41 C-C motif chemokine ligand 2 Homo sapiens 82-87 20959532-5 2011 In THP-1 cells, palmitate increased cellular TLR2 and TLR4 expression, generated reactive oxygen species (ROS), and increased NF-kappaB activity, IL-1beta, and MCP-1 release in a dose- and time-dependent manner. Palmitates 16-25 C-C motif chemokine ligand 2 Homo sapiens 160-165 21876349-5 2011 RESULTS: Urinary CCL2 significantly decreased during bindarit therapy (p = 0.008 vs. baseline) with a reduction that approximated 50% at study end. bindarit 53-61 C-C motif chemokine ligand 2 Homo sapiens 17-21 21345291-0 2011 Geranylgeranyl-pyrophosphate regulates secretion of pentraxin 3 and monocyte chemoattractant protein-1 from rheumatoid fibroblast-like synoviocytes in distinct manners. geranylgeranyl pyrophosphate 0-28 C-C motif chemokine ligand 2 Homo sapiens 68-102 20827464-1 2011 The preparation and characterization of heparin-immobilized microspheres which were used to bind acidic fibroblast growth factor (aFGF), vascular endothelial growth factor (VEGF), monocyte chemoattractant protein 1 (MCP-1/CCL2), and regulation upon activation normal T cell express sequence (RANTES/CCL5) is described. Heparin 40-47 C-C motif chemokine ligand 2 Homo sapiens 180-214 20827464-1 2011 The preparation and characterization of heparin-immobilized microspheres which were used to bind acidic fibroblast growth factor (aFGF), vascular endothelial growth factor (VEGF), monocyte chemoattractant protein 1 (MCP-1/CCL2), and regulation upon activation normal T cell express sequence (RANTES/CCL5) is described. Heparin 40-47 C-C motif chemokine ligand 2 Homo sapiens 216-221 20827464-1 2011 The preparation and characterization of heparin-immobilized microspheres which were used to bind acidic fibroblast growth factor (aFGF), vascular endothelial growth factor (VEGF), monocyte chemoattractant protein 1 (MCP-1/CCL2), and regulation upon activation normal T cell express sequence (RANTES/CCL5) is described. Heparin 40-47 C-C motif chemokine ligand 2 Homo sapiens 222-226 20827464-6 2011 These heparin-immobilized microspheres exhibited broad dynamic ranges for binding to the four cytokines (aFGF, 1.0-1,000 ng/mL; VEGF, 0.5-1,000 ng/mL; CCL2, 1.95-1,000 ng/mL; CCL5, 1.95-500 ng/mL). Heparin 6-13 C-C motif chemokine ligand 2 Homo sapiens 151-155 21224075-5 2011 12-O-tetradecanoylphorbol-13-acetate stimulated skin fibroblasts, secreting high levels of monocyte chemotactic protein-1, and neutralization of this chemokine eliminated almost completely the fibroblast-induced chemotaxis of macrophages. Tetradecanoylphorbol Acetate 0-36 C-C motif chemokine ligand 2 Homo sapiens 91-121 21092943-4 2011 These mAbs bind the extracellular domain of mouse TLR3, inhibit poly(I:C)-induced activation of HEK293T cells transfected with mTLR3, and reduce poly(I:C)-induced production of CCL2 and CXCL10 by primary mouse embryonic fibroblasts. Poly I-C 145-154 C-C motif chemokine ligand 2 Homo sapiens 177-181 21345291-7 2011 CONCLUSIONS: Although simvastatin inhibited the production of PTX3 and MCP-1 in RA FLS, the mechanisms were quite different. Simvastatin 22-33 C-C motif chemokine ligand 2 Homo sapiens 71-76 21345291-2 2011 In this study, we have investigated the mechanism by which simvastatin inhibits the production of the mediators of inflammation, such as pentraxin 3 (PTX3) and monocyte chemoattractant protein-1 (MCP-1), from fibroblast-like synoviocytes (FLS) derived from patients with RA. Simvastatin 59-70 C-C motif chemokine ligand 2 Homo sapiens 160-194 21345291-2 2011 In this study, we have investigated the mechanism by which simvastatin inhibits the production of the mediators of inflammation, such as pentraxin 3 (PTX3) and monocyte chemoattractant protein-1 (MCP-1), from fibroblast-like synoviocytes (FLS) derived from patients with RA. Simvastatin 59-70 C-C motif chemokine ligand 2 Homo sapiens 196-201 21345291-4 2011 RESULTS: Simvastatin both reduced the secretion of PTX3 and MCP-1 in FLS cultures and inhibited their mRNA expression in these cells. Simvastatin 9-20 C-C motif chemokine ligand 2 Homo sapiens 60-65 20950664-6 2011 CbpA could also induce the release of inflammatory cytokine interleukin-6, and chemokines CCL2, CXCL1, and CXCL8 from human bronchial epithelia cells. cbpa 0-4 C-C motif chemokine ligand 2 Homo sapiens 90-94 20956498-10 2011 Furthermore, metformin decreased IL-6 and MCP-1 gene expression in comparison with differentiated adipocytes. Metformin 13-22 C-C motif chemokine ligand 2 Homo sapiens 42-47 21071523-6 2011 Maleate increased urinary MCP-1 protein and mRNA more than the corresponding increases in NGAL. maleic acid 0-7 C-C motif chemokine ligand 2 Homo sapiens 26-31 21425908-6 2011 Exposing astrocytes to the TLR agonists LTA (TLR2), poly I:C (TLR3), LPS (TLR4) and unmethylated CpG ODN (TLR9) resulted in increased secretion of MCP-1/CCL2 and elevations in reactive oxygen species. Reactive Oxygen Species 176-199 C-C motif chemokine ligand 2 Homo sapiens 147-152 21787693-6 2011 Nivalenol reduced monocyte chemotactic protein (MCP)-1 secretion. nivalenol 0-9 C-C motif chemokine ligand 2 Homo sapiens 18-54 20939853-10 2011 The secretion of the inflammatory proteins IL-6, monocyte chemotactic protein-1/chemokine ligand 2 and macrophage inflammatory protein-1alpha/chemokine ligand 3 were also significantly decreased by glycine pretreatment. Glycine 198-205 C-C motif chemokine ligand 2 Homo sapiens 49-79 21878744-0 2011 Resveratrol inhibits monocytic cell chemotaxis to MCP-1 and prevents spontaneous endothelial cell migration through Rho kinase-dependent mechanism. Resveratrol 0-11 C-C motif chemokine ligand 2 Homo sapiens 50-55 21878744-11 2011 In monocytic cells, treatment with resveratrol significantly inhibited chemotaxis towards MCP-1 already at 1 micromol/L. Resveratrol 35-46 C-C motif chemokine ligand 2 Homo sapiens 90-95 21878744-12 2011 At a resveratrol concentration of 10 micromol/L, chemotaxis was reduced nearly to the negative control (unstimulated with MCP-1) levels. Resveratrol 5-16 C-C motif chemokine ligand 2 Homo sapiens 122-127 21878744-14 2011 In resveratrol treated monocytic cells, MCP-1-induced Erk phosphorylation downstream of CCR2 receptor was dose-dependently inhibited, as observed by Western blot analysis. Resveratrol 3-14 C-C motif chemokine ligand 2 Homo sapiens 40-45 21878744-15 2011 CONCLUSIONS: Resveratrol dose-dependently inhibited endothelial cell migration and MCP-1-induced monocytic cell chemotaxis. Resveratrol 13-24 C-C motif chemokine ligand 2 Homo sapiens 83-88 20382011-4 2011 We found that GPE attenuated TNFalpha-induced expression of inflammatory genes including interleukin (IL)-6, IL-1beta, IL-8, monocyte chemoattractant protein (MCP)-1, cyclooxygenase (COX)-2 and Toll-like receptor (TLR)-2. gpe 14-17 C-C motif chemokine ligand 2 Homo sapiens 125-165 22254128-10 2011 MCP-1 was highest in CRVO (595.7) > AMD (530.8) > DME (178). dme 56-59 C-C motif chemokine ligand 2 Homo sapiens 0-5 22254128-11 2011 The CBA reproducibility after frozen storage was examined to be most accurate for MCP1 (P = 0.91) > VEGF (P = 0.68) > IL-6 (P = 0.49). cba 4-7 C-C motif chemokine ligand 2 Homo sapiens 82-86 20437404-7 2011 Median urinary TGF-beta1 and MCP- 1 levels were 0.3 (range 0.0-28.1) and 18 (range 3-370) ng/mmol of creatinine, respectively. Creatinine 101-111 C-C motif chemokine ligand 2 Homo sapiens 29-35 20437404-8 2011 Urinary protein and MCP-1 to creatinine ratios were associated with slope, and this applied to both diabetic and nondiabetic patients separately. Creatinine 29-39 C-C motif chemokine ligand 2 Homo sapiens 20-25 21991356-8 2011 Our results also suggest a role for CCL-2 in maintaining the integrity of granuloma in asymptomatic individuals with latent infection in high TB burden settings. Terbium 142-144 C-C motif chemokine ligand 2 Homo sapiens 36-41 21687657-11 2011 Uncomplicated P. knowlesi patients had significantly lower levels of MCP-1 than uncomplicated P. falciparum patients (DPT, p = <0.001). diphenylthiosulfinate 118-121 C-C motif chemokine ligand 2 Homo sapiens 69-74 21931678-7 2011 In fact, sirtinol significantly reduced membrane expression of adhesion molecules in TNFa- or IL-1beta-stimulated cells, as well as the amount of CXCL10 and CCL2 released by HDMEC following TNFalpha treatment. sirtinol 9-17 C-C motif chemokine ligand 2 Homo sapiens 157-161 20943792-7 2010 RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1. Quercetin 9-18 C-C motif chemokine ligand 2 Homo sapiens 168-202 20853389-0 2010 Kinetic study of OH radical reactions with CF3CCl=CCl2, CF3CCl=CClCF3 and CF3CF=CFCF3. oh radical 17-27 C-C motif chemokine ligand 2 Homo sapiens 50-54 20943792-7 2010 RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1. Resveratrol 43-52 C-C motif chemokine ligand 2 Homo sapiens 168-202 21124011-9 2011 The serum level of monocyte chemotactic protein 1 was significantly decreased immediately after PMX-DHP. pmx-dhp 96-103 C-C motif chemokine ligand 2 Homo sapiens 19-49 20943792-7 2010 RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1. Quercetin 9-18 C-C motif chemokine ligand 2 Homo sapiens 204-209 20943792-7 2010 RESULTS: Quercetin, and to a lesser extent trans-RSV, attenuated the TNF-alpha-induced expression of inflammatory genes such as interleukin (IL)-6, IL-1beta, IL-8, and monocyte chemoattractant protein-1 (MCP-1) and the secretion of IL-6, IL-8, and MCP-1. Quercetin 9-18 C-C motif chemokine ligand 2 Homo sapiens 248-253 20841991-2 2010 Lopinavir, the most potent inducer of interleukin (IL)-8 expression, also inhibited dsRNA-induced monocyte chemotactic protein 1 expression. Lopinavir 0-9 C-C motif chemokine ligand 2 Homo sapiens 98-128 20937260-3 2010 In cultured proximal tubular cells, a saturated fatty acid, palmiate, increased the expression of monocyte chemoattractant protein-1 (MCP-1), but this effect was abrogated by co-incubation of monounsaturated fatty acid, oleate, or omega-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA). Fatty Acids 38-58 C-C motif chemokine ligand 2 Homo sapiens 98-132 20937260-3 2010 In cultured proximal tubular cells, a saturated fatty acid, palmiate, increased the expression of monocyte chemoattractant protein-1 (MCP-1), but this effect was abrogated by co-incubation of monounsaturated fatty acid, oleate, or omega-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA). Fatty Acids 38-58 C-C motif chemokine ligand 2 Homo sapiens 134-139 20937260-3 2010 In cultured proximal tubular cells, a saturated fatty acid, palmiate, increased the expression of monocyte chemoattractant protein-1 (MCP-1), but this effect was abrogated by co-incubation of monounsaturated fatty acid, oleate, or omega-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA). palmiate 60-68 C-C motif chemokine ligand 2 Homo sapiens 98-132 20937260-3 2010 In cultured proximal tubular cells, a saturated fatty acid, palmiate, increased the expression of monocyte chemoattractant protein-1 (MCP-1), but this effect was abrogated by co-incubation of monounsaturated fatty acid, oleate, or omega-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA). palmiate 60-68 C-C motif chemokine ligand 2 Homo sapiens 134-139 20937260-3 2010 In cultured proximal tubular cells, a saturated fatty acid, palmiate, increased the expression of monocyte chemoattractant protein-1 (MCP-1), but this effect was abrogated by co-incubation of monounsaturated fatty acid, oleate, or omega-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA). Fatty Acids, Monounsaturated 192-218 C-C motif chemokine ligand 2 Homo sapiens 98-132 20937260-3 2010 In cultured proximal tubular cells, a saturated fatty acid, palmiate, increased the expression of monocyte chemoattractant protein-1 (MCP-1), but this effect was abrogated by co-incubation of monounsaturated fatty acid, oleate, or omega-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA). Fatty Acids, Monounsaturated 192-218 C-C motif chemokine ligand 2 Homo sapiens 134-139 20937260-3 2010 In cultured proximal tubular cells, a saturated fatty acid, palmiate, increased the expression of monocyte chemoattractant protein-1 (MCP-1), but this effect was abrogated by co-incubation of monounsaturated fatty acid, oleate, or omega-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA). Oleic Acid 220-226 C-C motif chemokine ligand 2 Homo sapiens 98-132 20937260-3 2010 In cultured proximal tubular cells, a saturated fatty acid, palmiate, increased the expression of monocyte chemoattractant protein-1 (MCP-1), but this effect was abrogated by co-incubation of monounsaturated fatty acid, oleate, or omega-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA). Oleic Acid 220-226 C-C motif chemokine ligand 2 Homo sapiens 134-139 20937260-3 2010 In cultured proximal tubular cells, a saturated fatty acid, palmiate, increased the expression of monocyte chemoattractant protein-1 (MCP-1), but this effect was abrogated by co-incubation of monounsaturated fatty acid, oleate, or omega-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA). omega-3 polyunsaturated fatty acid 231-265 C-C motif chemokine ligand 2 Homo sapiens 98-132 20937260-3 2010 In cultured proximal tubular cells, a saturated fatty acid, palmiate, increased the expression of monocyte chemoattractant protein-1 (MCP-1), but this effect was abrogated by co-incubation of monounsaturated fatty acid, oleate, or omega-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA). omega-3 polyunsaturated fatty acid 231-265 C-C motif chemokine ligand 2 Homo sapiens 134-139 20937260-3 2010 In cultured proximal tubular cells, a saturated fatty acid, palmiate, increased the expression of monocyte chemoattractant protein-1 (MCP-1), but this effect was abrogated by co-incubation of monounsaturated fatty acid, oleate, or omega-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA). Eicosapentaenoic Acid 267-288 C-C motif chemokine ligand 2 Homo sapiens 98-132 20937260-3 2010 In cultured proximal tubular cells, a saturated fatty acid, palmiate, increased the expression of monocyte chemoattractant protein-1 (MCP-1), but this effect was abrogated by co-incubation of monounsaturated fatty acid, oleate, or omega-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA). Eicosapentaenoic Acid 267-288 C-C motif chemokine ligand 2 Homo sapiens 134-139 20937260-3 2010 In cultured proximal tubular cells, a saturated fatty acid, palmiate, increased the expression of monocyte chemoattractant protein-1 (MCP-1), but this effect was abrogated by co-incubation of monounsaturated fatty acid, oleate, or omega-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA). Eicosapentaenoic Acid 290-293 C-C motif chemokine ligand 2 Homo sapiens 98-132 20937260-3 2010 In cultured proximal tubular cells, a saturated fatty acid, palmiate, increased the expression of monocyte chemoattractant protein-1 (MCP-1), but this effect was abrogated by co-incubation of monounsaturated fatty acid, oleate, or omega-3 polyunsaturated fatty acid, eicosapentaenoic acid (EPA). Eicosapentaenoic Acid 290-293 C-C motif chemokine ligand 2 Homo sapiens 134-139 20937260-5 2010 Among the several PKC inhibitors, rottlerin, a PKCtheta inhibitor, prevented palmitate-induced MCP-1 expression via inactivation of NFB pathway. rottlerin 34-43 C-C motif chemokine ligand 2 Homo sapiens 95-100 20937260-5 2010 Among the several PKC inhibitors, rottlerin, a PKCtheta inhibitor, prevented palmitate-induced MCP-1 expression via inactivation of NFB pathway. Palmitates 77-86 C-C motif chemokine ligand 2 Homo sapiens 95-100 20937260-6 2010 Overexpression of dominant-negative PKCtheta also inhibited palmitate-induced activation of MCP-1 promoter. Palmitates 60-69 C-C motif chemokine ligand 2 Homo sapiens 92-97 21187454-4 2010 The CCL2 gene expression evaluated by RT-PCR was investigated in relation to chemo-response/clinical outcomes in the OC patients and to sensitivity to cisplatin/paclitaxel in the OCCLs. Cisplatin 151-160 C-C motif chemokine ligand 2 Homo sapiens 4-8 21187454-4 2010 The CCL2 gene expression evaluated by RT-PCR was investigated in relation to chemo-response/clinical outcomes in the OC patients and to sensitivity to cisplatin/paclitaxel in the OCCLs. Paclitaxel 161-171 C-C motif chemokine ligand 2 Homo sapiens 4-8 21187454-9 2010 The cells expressing higher levels of CCL2 were more sensitive to paclitaxel and cisplatin as compared to those lines expressing lower levels of this chemokine. Paclitaxel 66-76 C-C motif chemokine ligand 2 Homo sapiens 38-42 21187454-9 2010 The cells expressing higher levels of CCL2 were more sensitive to paclitaxel and cisplatin as compared to those lines expressing lower levels of this chemokine. Cisplatin 81-90 C-C motif chemokine ligand 2 Homo sapiens 38-42 21187454-10 2010 Up-regulation of CCL2 in the PAT-7 cell line further enhanced the response of these cells to paclitaxel (p = 0.0001) and led to decreased invasion (p = 0.0009). Paclitaxel 93-103 C-C motif chemokine ligand 2 Homo sapiens 17-21 20829061-6 2010 Furthermore, GW2580, a c-FMS kinase inhibitor, inhibited the induction of MCP-1 by M-CSF or IL-34 in a concentration dependent manner. 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine 13-19 C-C motif chemokine ligand 2 Homo sapiens 74-79 20582713-5 2010 RESULTS: Treatment with 50 mmol/L glucose markedly increased the level of IL-1beta, IL-18, TNF-alpha, PGE2, NO, TGF-beta1, MCP-1, MIP-1alpha, and RANTES. Glucose 34-41 C-C motif chemokine ligand 2 Homo sapiens 123-128 21199725-0 2010 Reactive oxygen species-activated p38/ERK 1/2 MAPK signaling pathway in the Mycobacterium bovis bacillus Calmette Guerin (BCG)-induced CCL2 secretion in human monocytic cell line THP-1. Reactive Oxygen Species 0-23 C-C motif chemokine ligand 2 Homo sapiens 135-139 21199725-2 2010 Here we assess the role of reactive oxygen species (ROS) in the secretion of the CCL2 and the activation of mitogen-activated protein kinases (MAPKs) by human monocytic cells infected with Mycobacterium bovis bacillus Calmette Guerin (BCG). Reactive Oxygen Species 27-50 C-C motif chemokine ligand 2 Homo sapiens 81-85 21199725-2 2010 Here we assess the role of reactive oxygen species (ROS) in the secretion of the CCL2 and the activation of mitogen-activated protein kinases (MAPKs) by human monocytic cells infected with Mycobacterium bovis bacillus Calmette Guerin (BCG). Reactive Oxygen Species 52-55 C-C motif chemokine ligand 2 Homo sapiens 81-85 21199725-6 2010 mRNA expression of CCL2 was increased in M. bovis BCG-infected monocytic cells, and this increase was abrogated by administration of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor diphenyleneiodonium (DPI). Adenine 150-157 C-C motif chemokine ligand 2 Homo sapiens 19-23 21199725-6 2010 mRNA expression of CCL2 was increased in M. bovis BCG-infected monocytic cells, and this increase was abrogated by administration of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor diphenyleneiodonium (DPI). diphenyleneiodonium 207-226 C-C motif chemokine ligand 2 Homo sapiens 19-23 21199725-6 2010 mRNA expression of CCL2 was increased in M. bovis BCG-infected monocytic cells, and this increase was abrogated by administration of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor diphenyleneiodonium (DPI). diphenyleneiodonium 228-231 C-C motif chemokine ligand 2 Homo sapiens 19-23 21199725-7 2010 Importantly, M. bovis BCG-induced CCL2 protein secretion was also inhibited by the NADPH oxidase inhibitor DPI, the selective inhibitor of NADPH oxidase apocynin, the mitochondrial electron transfer chain subunit I inhibitor rotenone and H(2)O(2) scavenging enzyme catalase, indicating that the inhibition is through the NADPH/ROS pathway. diphenyleneiodonium 107-110 C-C motif chemokine ligand 2 Homo sapiens 34-38 21199725-7 2010 Importantly, M. bovis BCG-induced CCL2 protein secretion was also inhibited by the NADPH oxidase inhibitor DPI, the selective inhibitor of NADPH oxidase apocynin, the mitochondrial electron transfer chain subunit I inhibitor rotenone and H(2)O(2) scavenging enzyme catalase, indicating that the inhibition is through the NADPH/ROS pathway. Rotenone 225-233 C-C motif chemokine ligand 2 Homo sapiens 34-38 21199725-7 2010 Importantly, M. bovis BCG-induced CCL2 protein secretion was also inhibited by the NADPH oxidase inhibitor DPI, the selective inhibitor of NADPH oxidase apocynin, the mitochondrial electron transfer chain subunit I inhibitor rotenone and H(2)O(2) scavenging enzyme catalase, indicating that the inhibition is through the NADPH/ROS pathway. Hydrogen Peroxide 238-246 C-C motif chemokine ligand 2 Homo sapiens 34-38 21199725-7 2010 Importantly, M. bovis BCG-induced CCL2 protein secretion was also inhibited by the NADPH oxidase inhibitor DPI, the selective inhibitor of NADPH oxidase apocynin, the mitochondrial electron transfer chain subunit I inhibitor rotenone and H(2)O(2) scavenging enzyme catalase, indicating that the inhibition is through the NADPH/ROS pathway. NADP 83-88 C-C motif chemokine ligand 2 Homo sapiens 34-38 21199725-7 2010 Importantly, M. bovis BCG-induced CCL2 protein secretion was also inhibited by the NADPH oxidase inhibitor DPI, the selective inhibitor of NADPH oxidase apocynin, the mitochondrial electron transfer chain subunit I inhibitor rotenone and H(2)O(2) scavenging enzyme catalase, indicating that the inhibition is through the NADPH/ROS pathway. Reactive Oxygen Species 327-330 C-C motif chemokine ligand 2 Homo sapiens 34-38 21199725-9 2010 CONCLUSIONS: These results strongly suggest that NADPH oxidase-derived ROS-mediated activation of p38 and ERK 1/2 is essential for the M. bovis BCG-induced CCL2 production. Reactive Oxygen Species 71-74 C-C motif chemokine ligand 2 Homo sapiens 156-160 20827028-6 2010 Serum tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1 levels were significantly decreased with losartan (P<0.05). Losartan 147-155 C-C motif chemokine ligand 2 Homo sapiens 65-105 21273686-6 2010 All three biomarkers of inflammation significantly decreased after atorvastatin: CRP from 4.08 +- 3.72 to 2.97 +- 3.26 mug/ml (p < 0.05), IL-6 from 20.66 +- 20.05 to 13.36 +- 11.21 pg/ml (p < 0.05) and MCP-1 from 271.08 +- 85.72 to 213.24 +- 115.09 pg/ml (p < 0.05). Atorvastatin 67-79 C-C motif chemokine ligand 2 Homo sapiens 208-213 20309792-9 2010 Molecular docking studies showed that the complementarity of prenylated flavonoids with the hydrophobic MD-2 pocket (indicating goodness of fit) directly predicted their relative ability to inhibit MCP-1 and IL-6 production. Flavonoids 72-82 C-C motif chemokine ligand 2 Homo sapiens 198-203 21029462-14 2010 We also found that targeting CCR2 enhances NTHI-induced up-regulation of MCP-1/CCL2 in SLFs. nthi 43-47 C-C motif chemokine ligand 2 Homo sapiens 73-78 21029462-14 2010 We also found that targeting CCR2 enhances NTHI-induced up-regulation of MCP-1/CCL2 in SLFs. nthi 43-47 C-C motif chemokine ligand 2 Homo sapiens 79-83 21029462-15 2010 CONCLUSIONS: Taken together, we suggest that NTHI-induced SLF-derived MCP-1/CCL2 is a key molecule contributing to inner ear inflammation through CCR2-mediated recruitment of monocytes. nthi 45-49 C-C motif chemokine ligand 2 Homo sapiens 70-75 21029462-15 2010 CONCLUSIONS: Taken together, we suggest that NTHI-induced SLF-derived MCP-1/CCL2 is a key molecule contributing to inner ear inflammation through CCR2-mediated recruitment of monocytes. nthi 45-49 C-C motif chemokine ligand 2 Homo sapiens 76-80 20339855-10 2010 No cytotoxic effects were identified with 25-OH, which highly stimulated ROS production, MCP-1, and VEGF secretion. 25-hydroxycholesterol 42-47 C-C motif chemokine ligand 2 Homo sapiens 89-94 20955273-0 2010 Biocompatibility of heparin-grafted hemodialysis membranes: impact on monocyte chemoattractant protein-1 circulating level and oxidative status. Heparin 20-27 C-C motif chemokine ligand 2 Homo sapiens 70-104 21029462-13 2010 We demonstrated that targeting MCP-1/CCL2 enhances NTHI-induced up-regulation of MCP-2/CCL8 in SLFs and up-regulates the basal expression of CCR2 in the splenocytes. nthi 51-55 C-C motif chemokine ligand 2 Homo sapiens 31-36 21029462-13 2010 We demonstrated that targeting MCP-1/CCL2 enhances NTHI-induced up-regulation of MCP-2/CCL8 in SLFs and up-regulates the basal expression of CCR2 in the splenocytes. nthi 51-55 C-C motif chemokine ligand 2 Homo sapiens 37-41 20601112-6 2010 DHEA and EPEA were found to decrease LPS induced adipocyte IL-6 and MCP-1 levels. Dehydroepiandrosterone 0-4 C-C motif chemokine ligand 2 Homo sapiens 68-73 20818133-0 2010 Indoxyl sulfate stimulates monocyte chemoattractant protein-1 expression in human umbilical vein endothelial cells by inducing oxidative stress through activation of the NADPH oxidase-nuclear factor-kappaB pathway. Indican 0-15 C-C motif chemokine ligand 2 Homo sapiens 27-61 20818133-11 2010 These results suggest that IS increases NADPH oxidase-derived ROS, which in turn, activates the MAPK/NF-kappaB pathway and leads to induction of MCP-1 expression in HUVEC. Reactive Oxygen Species 62-65 C-C motif chemokine ligand 2 Homo sapiens 145-150 20668453-7 2010 Interestingly, irbesartan inhibited MCP-1 production more strongly than losartan. Irbesartan 15-25 C-C motif chemokine ligand 2 Homo sapiens 36-41 20580034-0 2010 Epigallocatechin gallate-mediated protection against tumor necrosis factor-alpha-induced monocyte chemoattractant protein-1 expression is heme oxygenase-1 dependent. epigallocatechin gallate 0-24 C-C motif chemokine ligand 2 Homo sapiens 89-123 20580034-5 2010 Pretreatment with EGCG inhibited the secretion of monocyte chemoattractant protein-1 and the activation of activator protein-1 in porcine aortic endothelial cells stimulated with tumor necrosis factor-alpha. epigallocatechin gallate 18-22 C-C motif chemokine ligand 2 Homo sapiens 50-84 20809989-0 2010 Increased levels of CRP and MCP-1 are associated with previously unknown abnormal glucose regulation in patients with acute STEMI: a cohort study. Glucose 82-89 C-C motif chemokine ligand 2 Homo sapiens 28-33 20538801-4 2010 WPBs could also contain tPA, and in IL-1beta-treated cells, IL-8, IL-6, MCP-1, and GRO-alpha, and were the primary source for histamine or ionomycin-stimulated secretion of these molecules. Ionomycin 139-148 C-C motif chemokine ligand 2 Homo sapiens 72-77 20709957-5 2010 Because estrogens influence the rennin-angiotensin system, chronic treatment with t-RESV (15 mg/kg/day, orally) inhibited ovariectomy-induced arteriolar leukocyte adhesion by 81%, partly through a reduction of cell adhesion molecule (CAM) expression and circulating levels of cytokine-induced neutrophil chemoattractant, MCP-1, and MIP-1alpha. Resveratrol 82-88 C-C motif chemokine ligand 2 Homo sapiens 321-326 20809989-8 2010 High levels of CRP (>= 75 percentiles (33.13 mg/L)) and MCP-1 (>= 25 percentiles (190 ug/mL)) were associated with abnormal glucose regulation with an adjusted OR of 3.2 (95% CI 1.5, 6.8) and 7.6 (95% CI 1.7, 34.2), respectively. Glucose 130-137 C-C motif chemokine ligand 2 Homo sapiens 59-64 20809989-9 2010 CONCLUSION: Elevated levels of CRP and MCP-1 measured in patients early after an acute STEMI were associated with abnormal glucose regulation classified by an OGTT at three-month follow-up. Glucose 123-130 C-C motif chemokine ligand 2 Homo sapiens 39-44 20619710-1 2010 RATIONALE: We previously reported that mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is necessary for oxidized phospholipids to induce monocyte chemoattractant protein-1 (MCP-1) secretion by human aortic endothelial cells. Phospholipids 131-144 C-C motif chemokine ligand 2 Homo sapiens 191-196 20599874-0 2010 3-hydroxyanthranilic acid is independently associated with monocyte chemoattractant protein-1 (CCL2) and macrophage inflammatory protein-1beta (CCL4) in patients with chronic kidney disease. 3-Hydroxyanthranilic Acid 0-25 C-C motif chemokine ligand 2 Homo sapiens 59-93 20599874-0 2010 3-hydroxyanthranilic acid is independently associated with monocyte chemoattractant protein-1 (CCL2) and macrophage inflammatory protein-1beta (CCL4) in patients with chronic kidney disease. 3-Hydroxyanthranilic Acid 0-25 C-C motif chemokine ligand 2 Homo sapiens 95-99 20619710-1 2010 RATIONALE: We previously reported that mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is necessary for oxidized phospholipids to induce monocyte chemoattractant protein-1 (MCP-1) secretion by human aortic endothelial cells. Phospholipids 131-144 C-C motif chemokine ligand 2 Homo sapiens 155-189 20603779-6 2010 In experiments on adipocytes treated at day 14 post-differentiation, JTE-907, a synthetic cannabinoid, upregulated the expression of key inflammatory markers - IL-6, MCP-1 and IL-1 beta - and angiogenic factors - VEGF and ANGPTL4 - at 10 microM after 20 h of treatment, having also increased the expression of TRPV1 at 10 microM. Cannabinoids 90-101 C-C motif chemokine ligand 2 Homo sapiens 166-171 20576301-7 2010 A significant elevation in MCP-1 mRNA and protein expression in Caco-2 cells was detected after a 4h exposure to TNF-alpha. 4h 98-100 C-C motif chemokine ligand 2 Homo sapiens 27-32 20625355-6 2010 On univariate analysis, 6-month urinary CCL2 was a risk factor for developing 24-month IFTA, defined as ci+ct score more than 0 (odds ratio 1.045, 95% confidence interval: 1.005-1.084, P=0.028). ifta 87-91 C-C motif chemokine ligand 2 Homo sapiens 40-44 20625355-7 2010 Furthermore, CCL2 remained an independent predictor of IFTA on multivariate analysis (odds ratio 1.049, 95% confidence interval: 1.006-1.094, P=0.024) when adjusted for donor age, delayed graft function, deceased donation, and angiotensin-converting enzyme inhibitor/angiotensin receptor blocker exposure. ifta 55-59 C-C motif chemokine ligand 2 Homo sapiens 13-17 20625355-9 2010 CONCLUSION: This study demonstrates that early urinary CCL2 is an independent predictor for the subsequent development of IFTA at 24 months. ifta 122-126 C-C motif chemokine ligand 2 Homo sapiens 55-59 20576301-8 2010 Pre-incubation of Caco-2 cells with L. plantarum L2 for 2h resulted in an attenuation of both MCP-1 protein production and mRNA expression in TNF-alpha-stimulated cells. Deuterium 56-58 C-C motif chemokine ligand 2 Homo sapiens 94-99 20484496-5 2010 Results from oligonucleotide-based microarray, real-time PCR, and enzyme-linked immunosorbent assays indicated an upregulation of the fibrosis-associated chemokine (C-C motif) ligand 2 (CCL2) by the viral spike protein and the virus-like particles. Oligonucleotides 13-28 C-C motif chemokine ligand 2 Homo sapiens 186-190 20590818-4 2010 In this article, we demonstrate by immunocytochemistry that the skin lesions of patients treated with oral gefitinib had higher expression of CCL2 and CCL5 compared to normal human epidermis. Gefitinib 107-116 C-C motif chemokine ligand 2 Homo sapiens 142-146 20590818-5 2010 Further, PD153035, a gefitinib prototype, induced CCL2 and CCL5 mRNA and protein expression in HaCaT and HSC-1 keratinocyte cell lines with or without interleukin-1 (IL-1) treatment in vitro. 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline 9-17 C-C motif chemokine ligand 2 Homo sapiens 50-54 20590818-5 2010 Further, PD153035, a gefitinib prototype, induced CCL2 and CCL5 mRNA and protein expression in HaCaT and HSC-1 keratinocyte cell lines with or without interleukin-1 (IL-1) treatment in vitro. Gefitinib 21-30 C-C motif chemokine ligand 2 Homo sapiens 50-54 20590818-8 2010 Taken together, our data strongly suggest that IL-1-mediated signalling is activated to induce the high expression of CCL2 and CCL5 via reduction in IL-1R2 in the skin lesions caused by gefitinib. Gefitinib 186-195 C-C motif chemokine ligand 2 Homo sapiens 118-122 20505014-6 2010 RT-qPCR and proteome analysis of human islets incubated with 16.7 mM/l glucose revealed a significant decrease in pro-angiogenic factors including vascular endothelial growth factor (VEGF) mRNA by 20% and VEGF protein levels by 42% as well as additional proteins such as fibroblast growth factor-4 by 41%, MMP9 by 18%, monocyte chemoattractant protein-1 by 21%, and prolactin by 25%. Glucose 71-78 C-C motif chemokine ligand 2 Homo sapiens 319-353 20504881-0 2010 Parenteral iron formulations differentially affect MCP-1, HO-1, and NGAL gene expression and renal responses to injury. Iron 11-15 C-C motif chemokine ligand 2 Homo sapiens 51-56 20813681-10 2010 CONCLUSIONS: Preoperative intravenous LOR injection may increase serum RANTES level and decrease MCP-1 and SDF-1alpha expressions to effectively relieve the perioperative immune disorders caused by TAH, and the effect is more potent at the dose of 16 mg. lornoxicam 38-41 C-C motif chemokine ligand 2 Homo sapiens 97-102 20369226-0 2010 Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes. Palmitates 0-9 C-C motif chemokine ligand 2 Homo sapiens 85-89 20434448-0 2010 Rho-kinase mediates lysophosphatidic acid-induced IL-8 and MCP-1 production via p38 and JNK pathways in human endothelial cells. lysophosphatidic acid 20-41 C-C motif chemokine ligand 2 Homo sapiens 59-64 20185130-5 2010 We found that 5"-NIO inhibited TNF-alpha induced MCP-1 and IL-8 expression at the RNA and protein levels in HUVECs. 5'-nitroindirubinoxime 14-20 C-C motif chemokine ligand 2 Homo sapiens 49-54 20185130-6 2010 Specifically, 5"-NIO significantly inhibited the TNF-alpha stimulated release of MCP-1 and IL-8, with levels that were only 19.8% and 30.9% of those of untreated control cells, respectively. 5'-nitroindirubinoxime 14-20 C-C motif chemokine ligand 2 Homo sapiens 81-86 20463188-2 2010 METHODS: Guanine (G) to adenine (A) single nucleotide polymorphism (SNP) of the -2518 MCP-1 promoter region in pSS and healthy controls was determined by the PCR-restriction fragment length polymorphism technique. Guanine 9-16 C-C motif chemokine ligand 2 Homo sapiens 86-91 20463188-2 2010 METHODS: Guanine (G) to adenine (A) single nucleotide polymorphism (SNP) of the -2518 MCP-1 promoter region in pSS and healthy controls was determined by the PCR-restriction fragment length polymorphism technique. Adenine 24-31 C-C motif chemokine ligand 2 Homo sapiens 86-91 20463188-7 2010 Primary salivary epithelial cells in vitro from pSS produced MCP-1, which was significantly stimulated by IFN-gamma, as identified by both ELISA and RT-PCR. pss 48-51 C-C motif chemokine ligand 2 Homo sapiens 61-66 20463188-9 2010 CONCLUSIONS: MCP-1 is involved in the disease susceptibility of pSS in the Japanese population. pss 64-67 C-C motif chemokine ligand 2 Homo sapiens 13-18 19958313-7 2010 Stimulation with histamine or a H(4)R agonist downregulated the chemokine (C-C motif) ligand 2 (CCL2) in human monocyte-derived LC and primary LC. Histamine 17-26 C-C motif chemokine ligand 2 Homo sapiens 64-94 19958313-7 2010 Stimulation with histamine or a H(4)R agonist downregulated the chemokine (C-C motif) ligand 2 (CCL2) in human monocyte-derived LC and primary LC. Histamine 17-26 C-C motif chemokine ligand 2 Homo sapiens 96-100 20040767-5 2010 While exploring a lack of association between this polymorphism and EDTA plasma MCP-1 concentrations (P = .82), we determined that both clotting and exogenous heparan sulfate (unfractionated heparin) released substantial amounts of MCP-1 from Darc. Heparitin Sulfate 159-174 C-C motif chemokine ligand 2 Homo sapiens 232-237 20357375-6 2010 After 4 weeks, as compared with control subjects, patients receiving sitagliptin showed a significant increase in EPCs and SDF-1alpha and a decrease in MCP-1. Sitagliptin Phosphate 69-80 C-C motif chemokine ligand 2 Homo sapiens 152-157 20711880-0 2010 Effect of the C-terminal domain peptide fragment (65-76) of monocytic chemotactic protein-1 (MCP-1) on the interaction between MCP-1 and heparin. Heparin 137-144 C-C motif chemokine ligand 2 Homo sapiens 60-91 20711880-0 2010 Effect of the C-terminal domain peptide fragment (65-76) of monocytic chemotactic protein-1 (MCP-1) on the interaction between MCP-1 and heparin. Heparin 137-144 C-C motif chemokine ligand 2 Homo sapiens 93-98 20711880-0 2010 Effect of the C-terminal domain peptide fragment (65-76) of monocytic chemotactic protein-1 (MCP-1) on the interaction between MCP-1 and heparin. Heparin 137-144 C-C motif chemokine ligand 2 Homo sapiens 127-132 20201957-4 2010 In vitro, baclofen reduces chemotaxis of human peripheral blood mononuclear cells towards CCL2, CCL5, CXCL10, CXCL2 and CX3CL1 in a dose-dependant manner. Baclofen 10-18 C-C motif chemokine ligand 2 Homo sapiens 90-94 20206138-5 2010 In human HaCaT keratinocytes falcarinol increased the expression of the pro-allergic chemokines IL-8 and CCL2/MCP-1 in a CB(1) receptor-dependent manner. falcarinol 29-39 C-C motif chemokine ligand 2 Homo sapiens 105-109 20558542-7 2010 Inhibition of c-Src activity and silencing c-Src expression abrogated the light chain-induced MCP-1 response, but had no effect on H(2)O(2), indicating that production of H(2)O(2) is upstream of c-Src in the signaling cascade. Water 171-176 C-C motif chemokine ligand 2 Homo sapiens 94-99 20558542-9 2010 These data show that intracellular H(2)O(2) induced by endocytosis of monoclonal free light chains oxidizes and activates c-Src, which promotes release of MCP-1. Hydrogen Peroxide 35-43 C-C motif chemokine ligand 2 Homo sapiens 155-160 20410153-2 2010 Our objective was to evaluate the capacity of atorvastatin to reduce plasma levels of interferon-regulated chemokines (CCL2, CCL3 and CXCL9) and to study the correlation between these chemokines and disease activity in patients with systemic lupus erythematosus. Atorvastatin 46-58 C-C motif chemokine ligand 2 Homo sapiens 119-123 20179016-8 2010 These cells inhibited T cell proliferation, were unable to fully differentiate into mature dendritic cells, were associated with dexamethasone-mediated changes in CCL2 levels, and could be re-created in vitro using tumor supernatants. Dexamethasone 129-142 C-C motif chemokine ligand 2 Homo sapiens 163-167 20179016-9 2010 We provide evidence that tumors express high levels of CCL2, can contain high numbers of CD14(+) cells, that tumor supernatants can transform CD14(+)HLA-DR(+) cells into CD14(+)HLA-DR(lo/neg) immune suppressors, and that dexamethasone reduces CCL2 in vitro and is correlated with reduction of CCL2 in vivo. Dexamethasone 221-234 C-C motif chemokine ligand 2 Homo sapiens 55-59 20692455-12 2010 CONCLUSIONS: These data show that MCP-1 gene expression regulated by the -2518 G/A polymorphism, is correlated with glucose-stimulated insulin release. Glucose 116-123 C-C motif chemokine ligand 2 Homo sapiens 34-39 20206138-5 2010 In human HaCaT keratinocytes falcarinol increased the expression of the pro-allergic chemokines IL-8 and CCL2/MCP-1 in a CB(1) receptor-dependent manner. falcarinol 29-39 C-C motif chemokine ligand 2 Homo sapiens 110-115 20092409-3 2010 We further observed that supplementation with H(2)S or an endogenous precursor of H(2)S (l-cysteine) in culture medium prevents IL-8 and MCP-1 secretion in high-glucose-treated human U937 monocytes. Hydrogen Sulfide 46-51 C-C motif chemokine ligand 2 Homo sapiens 137-142 20354174-4 2010 We now demonstrate that cocaine induces MCP-1 in rodent microglia through translocation of the sigma receptor to the lipid raft microdomains of the plasma membrane. Cocaine 24-31 C-C motif chemokine ligand 2 Homo sapiens 40-45 20092409-3 2010 We further observed that supplementation with H(2)S or an endogenous precursor of H(2)S (l-cysteine) in culture medium prevents IL-8 and MCP-1 secretion in high-glucose-treated human U937 monocytes. Hydrogen Sulfide 82-87 C-C motif chemokine ligand 2 Homo sapiens 137-142 20092409-3 2010 We further observed that supplementation with H(2)S or an endogenous precursor of H(2)S (l-cysteine) in culture medium prevents IL-8 and MCP-1 secretion in high-glucose-treated human U937 monocytes. Cysteine 89-99 C-C motif chemokine ligand 2 Homo sapiens 137-142 20819511-6 2010 Activation of p38 mitogen activated protein kinase and NF-kappaB, the expression of intercellular adhesion molecule-1 and monocyte chemotactic protein-1, which were only mildly affected by aspirin or pravastatin alone, were significantly attenuated by their combination. Aspirin 189-196 C-C motif chemokine ligand 2 Homo sapiens 122-152 20819511-6 2010 Activation of p38 mitogen activated protein kinase and NF-kappaB, the expression of intercellular adhesion molecule-1 and monocyte chemotactic protein-1, which were only mildly affected by aspirin or pravastatin alone, were significantly attenuated by their combination. Pravastatin 200-211 C-C motif chemokine ligand 2 Homo sapiens 122-152 20167660-5 2010 At the 24-hour postcollar implantation, the endothelial expression of vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and monocyte chemotactic protein-1 was markedly decreased in the niacin-supplemented animals compared with controls. Niacin 205-211 C-C motif chemokine ligand 2 Homo sapiens 144-174 20200316-11 2010 Finally, linoleic acid activates NF-kappaB and upregulates NF-kappaB-mediated LPL and MCP-1 expression in cultured VSMC. Linoleic Acid 9-22 C-C motif chemokine ligand 2 Homo sapiens 86-91 20200316-11 2010 Finally, linoleic acid activates NF-kappaB and upregulates NF-kappaB-mediated LPL and MCP-1 expression in cultured VSMC. vsmc 115-119 C-C motif chemokine ligand 2 Homo sapiens 86-91 20497022-5 2010 COPD group had higher plasma MCP1 levels than healthy participants (257.0 versus 194.4 pg/mL) in the univariate analysis (P = .005); and in stepwise liner regression analysis after adjustment for age, alcohol, body mass index, cancer history, and steroid use (P = .002; 95% confidence interval [CI]: 30.72-128.02). Alcohols 201-208 C-C motif chemokine ligand 2 Homo sapiens 29-33 20497022-5 2010 COPD group had higher plasma MCP1 levels than healthy participants (257.0 versus 194.4 pg/mL) in the univariate analysis (P = .005); and in stepwise liner regression analysis after adjustment for age, alcohol, body mass index, cancer history, and steroid use (P = .002; 95% confidence interval [CI]: 30.72-128.02). Steroids 247-254 C-C motif chemokine ligand 2 Homo sapiens 29-33 19960026-4 2010 Patients with a more impaired acetylcholine-dependent vasodilation (first tertile) had increased levels of e-selectin (P=0.009), p-selectin (P<0.001), monocyte chemotactic protein type 1 (MCP-1; P=0.012) and the tissue inhibitor of metalloproteinases type 1 (TIMP-1; P=0.044), which in turn showed significant inverse correlations with maximal endothelium-dependent vasodilation. Acetylcholine 30-43 C-C motif chemokine ligand 2 Homo sapiens 154-189 19960026-4 2010 Patients with a more impaired acetylcholine-dependent vasodilation (first tertile) had increased levels of e-selectin (P=0.009), p-selectin (P<0.001), monocyte chemotactic protein type 1 (MCP-1; P=0.012) and the tissue inhibitor of metalloproteinases type 1 (TIMP-1; P=0.044), which in turn showed significant inverse correlations with maximal endothelium-dependent vasodilation. Acetylcholine 30-43 C-C motif chemokine ligand 2 Homo sapiens 191-196 19998383-5 2010 A coculture of 3T3-L1 adipocytes and RAW 264 macrophages markedly enhanced the production of tumor necrosis factor-alpha, monocyte chemoattractant protein-1, and nitric oxide compared with the sum of their single cultures; however, treatment with diosgenin inhibited the production of these proinflammatory mediators. Diosgenin 247-256 C-C motif chemokine ligand 2 Homo sapiens 122-156 20438710-4 2010 Aldosterone also dose-dependently increased MCP-1, TGF-beta and type III collagen mRNA levels in MRC-5 cells, which were suppressed by nifedipine, but not amlodipine, a control calcium channel blocker. Aldosterone 0-11 C-C motif chemokine ligand 2 Homo sapiens 44-49 20438710-4 2010 Aldosterone also dose-dependently increased MCP-1, TGF-beta and type III collagen mRNA levels in MRC-5 cells, which were suppressed by nifedipine, but not amlodipine, a control calcium channel blocker. Nifedipine 135-145 C-C motif chemokine ligand 2 Homo sapiens 44-49 20526368-0 2010 Palmitate induced IL-6 and MCP-1 expression in human bladder smooth muscle cells provides a link between diabetes and urinary tract infections. Palmitates 0-9 C-C motif chemokine ligand 2 Homo sapiens 27-32 20154064-8 2010 In addition, treatment with 17-DMAG significantly reduced monocyte chemoattractant protein-1 levels, both in plaques and in plasma. 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin 28-35 C-C motif chemokine ligand 2 Homo sapiens 58-92 20371128-0 2010 Hydrochloride pioglitazone decreases urinary monocyte chemoattractant protein-1 excretion in type 2 diabetics. hydrochloride 0-13 C-C motif chemokine ligand 2 Homo sapiens 45-79 20371128-0 2010 Hydrochloride pioglitazone decreases urinary monocyte chemoattractant protein-1 excretion in type 2 diabetics. Pioglitazone 14-26 C-C motif chemokine ligand 2 Homo sapiens 45-79 20371128-1 2010 AIM: To observe the effects of hydrochloride pioglitazone on monocyte chemoattractant protein-1 (MCP-1) excretion in type 2 diabetics and explore its reno-protective mechanism. hydrochloride 31-44 C-C motif chemokine ligand 2 Homo sapiens 61-95 20371128-1 2010 AIM: To observe the effects of hydrochloride pioglitazone on monocyte chemoattractant protein-1 (MCP-1) excretion in type 2 diabetics and explore its reno-protective mechanism. hydrochloride 31-44 C-C motif chemokine ligand 2 Homo sapiens 97-102 20371128-1 2010 AIM: To observe the effects of hydrochloride pioglitazone on monocyte chemoattractant protein-1 (MCP-1) excretion in type 2 diabetics and explore its reno-protective mechanism. Pioglitazone 45-57 C-C motif chemokine ligand 2 Homo sapiens 61-95 20371128-1 2010 AIM: To observe the effects of hydrochloride pioglitazone on monocyte chemoattractant protein-1 (MCP-1) excretion in type 2 diabetics and explore its reno-protective mechanism. Pioglitazone 45-57 C-C motif chemokine ligand 2 Homo sapiens 97-102 20371128-8 2010 CONCLUSIONS: Pioglitazone can decrease urinary albumin and MCP-1 excretion in type 2 diabetics, which may partly contribute to its reno-protection by inhibiting the inflammation reaction in vivo. Pioglitazone 13-25 C-C motif chemokine ligand 2 Homo sapiens 59-64 20526368-10 2010 MCP-1 was moderately upregulated by palmitate but was strongly upregulated by LPS involving NF-kappaB and MEK1 dependent pathways. Palmitates 36-45 C-C motif chemokine ligand 2 Homo sapiens 0-5 20490773-0 2010 SP600125, an inhibitor of c-Jun NH2-terminal kinase, blocks expression of angiotensin II-induced monocyte chemoattractant protein-1 in human mesangial cells. pyrazolanthrone 0-8 C-C motif chemokine ligand 2 Homo sapiens 97-131 20222014-8 2010 In addition, AC-treated MSC secreted interleukin (IL)-8, monocyte chemoattractant protein-1, and RANTES, which might induce chemotaxis of CD4+ T cells to the inflamed joints. Charcoal 13-15 C-C motif chemokine ligand 2 Homo sapiens 57-91 20187772-9 2010 Muscle mRNA expression for IL-8 (6.4-fold), MCP-1 (4.7-fold), and IL-6 (7.3-fold) increased substantially after carbohydrate ingestion. Carbohydrates 112-124 C-C motif chemokine ligand 2 Homo sapiens 44-49 20490773-9 2010 SP600125 also reduced MCP-1 mRNA stability: the halflife of MCP-1 mRNA was approximately 5 hours in cells treated with Ang II only, but was reduced to 2 hours when treated with a combination of Ang II and SP600125. pyrazolanthrone 0-8 C-C motif chemokine ligand 2 Homo sapiens 22-27 20490773-9 2010 SP600125 also reduced MCP-1 mRNA stability: the halflife of MCP-1 mRNA was approximately 5 hours in cells treated with Ang II only, but was reduced to 2 hours when treated with a combination of Ang II and SP600125. pyrazolanthrone 0-8 C-C motif chemokine ligand 2 Homo sapiens 60-65 20490773-9 2010 SP600125 also reduced MCP-1 mRNA stability: the halflife of MCP-1 mRNA was approximately 5 hours in cells treated with Ang II only, but was reduced to 2 hours when treated with a combination of Ang II and SP600125. pyrazolanthrone 205-213 C-C motif chemokine ligand 2 Homo sapiens 22-27 20177146-3 2010 Inhibition of p38 MAPK and JNK by their specific inhibitors (SB203580 and SP600125), or inhibition by a dominant negative mutant of p38 MAPK dramatically decreased SAA-induced CCL2 production. SB 203580 61-69 C-C motif chemokine ligand 2 Homo sapiens 176-180 20490773-9 2010 SP600125 also reduced MCP-1 mRNA stability: the halflife of MCP-1 mRNA was approximately 5 hours in cells treated with Ang II only, but was reduced to 2 hours when treated with a combination of Ang II and SP600125. pyrazolanthrone 205-213 C-C motif chemokine ligand 2 Homo sapiens 60-65 20177146-3 2010 Inhibition of p38 MAPK and JNK by their specific inhibitors (SB203580 and SP600125), or inhibition by a dominant negative mutant of p38 MAPK dramatically decreased SAA-induced CCL2 production. pyrazolanthrone 74-82 C-C motif chemokine ligand 2 Homo sapiens 176-180 20086201-6 2010 In the DIO and DEX groups, circulating levels of MCP-1, MIP-1alpha, IL-15, and IL-18 were decreased, and adiponectin was increased (P < 0.05 for all). 3,3'-Dioctadecyloxacarbocyanine perchlorate 7-10 C-C motif chemokine ligand 2 Homo sapiens 49-54 20337495-0 2010 2-MeS-beta,gamma-CCl2-ATP is a potent agent for reducing intraocular pressure. 2-mes-beta 0-10 C-C motif chemokine ligand 2 Homo sapiens 17-21 20086201-6 2010 In the DIO and DEX groups, circulating levels of MCP-1, MIP-1alpha, IL-15, and IL-18 were decreased, and adiponectin was increased (P < 0.05 for all). Dextromethorphan 15-18 C-C motif chemokine ligand 2 Homo sapiens 49-54 20119897-8 2010 RESULTS: Treatment of human islets with RvE1 (500 nM) for 24 h reduced LPS-induced increase in mRNA and protein levels of selected pro-inflammatory markers (IL-8, MCP-1, and TF). lps 71-74 C-C motif chemokine ligand 2 Homo sapiens 163-168 20074254-3 2010 The aims of this study was to examined the effects of CRP on expressions of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1), and the possible mechanisms of atorvastatin on CRP-induced IL-6 and MCP-1 production in cultured human pulmonary artery smooth muscle cells (PASMCs). Atorvastatin 176-188 C-C motif chemokine ligand 2 Homo sapiens 137-142 20074254-3 2010 The aims of this study was to examined the effects of CRP on expressions of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1), and the possible mechanisms of atorvastatin on CRP-induced IL-6 and MCP-1 production in cultured human pulmonary artery smooth muscle cells (PASMCs). Atorvastatin 176-188 C-C motif chemokine ligand 2 Homo sapiens 213-218 20074254-10 2010 Preincubation with 0.1-10 micromol/L of atorvastatin significantly decreased the secretions of IL-6 and MCP-1 induced by CRP. Atorvastatin 40-52 C-C motif chemokine ligand 2 Homo sapiens 104-109 20074254-11 2010 Moreover, 10 micromol/L of atorvastatin completely abrogated CRP-induced increase in IL-6 and MCP-1 by attenuating the activation of NF-kappaB. Atorvastatin 27-39 C-C motif chemokine ligand 2 Homo sapiens 94-99 19951731-5 2010 Affinity peptides capable of sequestering MCP-1 were identified from CCR2 (a G protein-coupled receptor for MCP-1) and incorporated within PEG hydrogels via a thiol-acrylate photopolymerization. Sulfhydryl Compounds 159-164 C-C motif chemokine ligand 2 Homo sapiens 42-47 19918244-10 2010 Increases in CSF KYN and QUIN were correlated with increased CSF IFN-alpha, soluble tumor necrosis factor-alpha receptor 2 and monocyte chemoattractant protein-1 as well as increased depressive symptoms. Kynurenine 17-20 C-C motif chemokine ligand 2 Homo sapiens 127-161 19918244-10 2010 Increases in CSF KYN and QUIN were correlated with increased CSF IFN-alpha, soluble tumor necrosis factor-alpha receptor 2 and monocyte chemoattractant protein-1 as well as increased depressive symptoms. Quinolinic Acid 25-29 C-C motif chemokine ligand 2 Homo sapiens 127-161 19902472-7 2010 Proliferation assays showed that MCP-1 stimulates the proliferation of PrEC, but not PrSC, and that a specific MCP-1 antagonist (RS102895) suppressed this effect. RS 102895 129-137 C-C motif chemokine ligand 2 Homo sapiens 111-116 20097750-4 2010 We have therefore generated novel MCP-1/CCL2 mutants with increased GAG binding affinity and knocked out CCR2 activity, which were designed to interrupt the MCP-1/CCL2-related signaling cascade. Glycosaminoglycans 68-71 C-C motif chemokine ligand 2 Homo sapiens 34-39 20097750-4 2010 We have therefore generated novel MCP-1/CCL2 mutants with increased GAG binding affinity and knocked out CCR2 activity, which were designed to interrupt the MCP-1/CCL2-related signaling cascade. Glycosaminoglycans 68-71 C-C motif chemokine ligand 2 Homo sapiens 40-44 20097750-4 2010 We have therefore generated novel MCP-1/CCL2 mutants with increased GAG binding affinity and knocked out CCR2 activity, which were designed to interrupt the MCP-1/CCL2-related signaling cascade. Glycosaminoglycans 68-71 C-C motif chemokine ligand 2 Homo sapiens 157-162 20097750-4 2010 We have therefore generated novel MCP-1/CCL2 mutants with increased GAG binding affinity and knocked out CCR2 activity, which were designed to interrupt the MCP-1/CCL2-related signaling cascade. Glycosaminoglycans 68-71 C-C motif chemokine ligand 2 Homo sapiens 163-167 20097750-5 2010 We provide evidence that our lead mutant MCP-1(Y13A/S21K/Q23R) exhibits a 4-fold higher affinity toward the natural MCP-1 GAG ligand heparan sulfate and that it shows a complete deficiency in activating CCR2 on THP-1 cells. Heparitin Sulfate 133-148 C-C motif chemokine ligand 2 Homo sapiens 41-46 20097750-5 2010 We provide evidence that our lead mutant MCP-1(Y13A/S21K/Q23R) exhibits a 4-fold higher affinity toward the natural MCP-1 GAG ligand heparan sulfate and that it shows a complete deficiency in activating CCR2 on THP-1 cells. Heparitin Sulfate 133-148 C-C motif chemokine ligand 2 Homo sapiens 116-121 19736361-13 2010 Preincubation of HSCs with TAK779, a CCR5 receptor antagonist, prevented gp120-mediated chemotaxis and monocyte chemoattractant protein-1 secretion. TAK 779 27-33 C-C motif chemokine ligand 2 Homo sapiens 103-137 20492298-5 2010 14.68 mmol/L concentration of limonene diminished MCP-1 production via NF-kappa B activation comparable to the addition of the proteasomal inhibitor MG132. Limonene 30-38 C-C motif chemokine ligand 2 Homo sapiens 50-55 19578979-0 2010 Mycophenolic acid inhibits albumin-induced MCP-1 expression in renal tubular epithelial cells through the p38 MAPK pathway. Mycophenolic Acid 0-17 C-C motif chemokine ligand 2 Homo sapiens 43-48 20044439-3 2010 To profile LPA-induced cytokine production in vascular smooth muscle cells (SMCs), we used a cytokine antibody array system and found that LPA prominently induces the secretion of IL-6 and monocyte chemoattractant protein (MCP)-1 from human aortic SMCs (HASMCs). lysophosphatidic acid 11-14 C-C motif chemokine ligand 2 Homo sapiens 189-229 20044439-4 2010 The mechanism by which LPA induces MCP-1 expression in SMCs has been previously reported. lysophosphatidic acid 23-26 C-C motif chemokine ligand 2 Homo sapiens 35-40 20065062-3 2010 Daptomycin led to lower CSF concentrations of interleukin 1beta (IL-1beta), IL-10, IL-18, monocyte chemoattractant protein 1 (MCP-1), and macrophage inflammatory protein 1 alpha (MIP-1alpha) (P < 0.05). Daptomycin 0-10 C-C motif chemokine ligand 2 Homo sapiens 90-124 20065062-3 2010 Daptomycin led to lower CSF concentrations of interleukin 1beta (IL-1beta), IL-10, IL-18, monocyte chemoattractant protein 1 (MCP-1), and macrophage inflammatory protein 1 alpha (MIP-1alpha) (P < 0.05). Daptomycin 0-10 C-C motif chemokine ligand 2 Homo sapiens 126-131 20130114-6 2010 Activation of TRL4 by lipopolysaccharide (LPS) and TLR1/2 by Pam(3)Cys up-regulates IL-6 and MCP-1 release in adipocytes via specific activation of Erk. trl4 14-18 C-C motif chemokine ligand 2 Homo sapiens 93-98 19781706-0 2010 Anti-inflammatory effects of nicotinic acid in adipocytes demonstrated by suppression of fractalkine, RANTES, and MCP-1 and upregulation of adiponectin. Niacin 29-43 C-C motif chemokine ligand 2 Homo sapiens 114-119 20136831-7 2010 Co-incubation of mevalonate and geranylgeranyl pyrophosphate, but not farnesyl pyrophosphate, reversed the inhibitory effects of statins on MCP-1 expression. Mevalonic Acid 17-27 C-C motif chemokine ligand 2 Homo sapiens 140-145 20136831-7 2010 Co-incubation of mevalonate and geranylgeranyl pyrophosphate, but not farnesyl pyrophosphate, reversed the inhibitory effects of statins on MCP-1 expression. geranylgeranyl pyrophosphate 32-60 C-C motif chemokine ligand 2 Homo sapiens 140-145 20130114-10 2010 In human adipocytes isolated from noninflamed adipose tissue, LPS and Pam(3)Cys, but not MALP-2, are potent inducers of IL-6 and MCP-1. (3)cys 73-79 C-C motif chemokine ligand 2 Homo sapiens 129-134 19642141-6 2010 MCP-1/CCL2"s chemotactic activities rely on tyrosine phosphorylation of focal adhesion components and depend on matrix metalloproteinase (MMP)-2 and MMP-9. Tyrosine 44-52 C-C motif chemokine ligand 2 Homo sapiens 0-5 20339966-2 2010 The aim of this study was to clarify whether ramipril was a therapeutic agent against monocyte chemoattractant protein 1 (MCP-1), interleukin 18 (IL-18), and interleukin 10 (IL-10) in elderly patients with ACS. Ramipril 45-53 C-C motif chemokine ligand 2 Homo sapiens 86-120 20339966-2 2010 The aim of this study was to clarify whether ramipril was a therapeutic agent against monocyte chemoattractant protein 1 (MCP-1), interleukin 18 (IL-18), and interleukin 10 (IL-10) in elderly patients with ACS. Ramipril 45-53 C-C motif chemokine ligand 2 Homo sapiens 122-127 20339966-6 2010 After treating with ramipril, the levels of MCP-1 and IL-18 were decreased in elderly patients with ACS. Ramipril 20-28 C-C motif chemokine ligand 2 Homo sapiens 44-49 19642141-6 2010 MCP-1/CCL2"s chemotactic activities rely on tyrosine phosphorylation of focal adhesion components and depend on matrix metalloproteinase (MMP)-2 and MMP-9. Tyrosine 44-52 C-C motif chemokine ligand 2 Homo sapiens 6-10 20383942-3 2010 In the present study, we found that bicyclol pre-treatment could attenuate the production of the inflammatory cytokines (TNF-alpha and IL-18) and chemokines (MCP-1, MIP-1 alpha and Rantes) and inhibit the activation of the p65-NF-kappaB and MAPK signaling pathways in CpG-ODN 2006-stimulated L02 hepatocytes in a dose-dependent manner. bicyclol 36-44 C-C motif chemokine ligand 2 Homo sapiens 158-163 19923143-2 2010 METHODS AND RESULTS: High-glucose (HG) super-induced interleukin (IL)-6, CCL-2, transforming growth factor (TGF)-beta, vascular endothelial growth factor (VEGF) and B(2)K receptor (B(2)KR) mRNA in cultured proximal tubular epithelial cells (PTEC), whereas bradykinin (BK) upregulated IL-6, CCL-2 and TGF-beta mRNA. Glucose 26-33 C-C motif chemokine ligand 2 Homo sapiens 73-78 19923143-2 2010 METHODS AND RESULTS: High-glucose (HG) super-induced interleukin (IL)-6, CCL-2, transforming growth factor (TGF)-beta, vascular endothelial growth factor (VEGF) and B(2)K receptor (B(2)KR) mRNA in cultured proximal tubular epithelial cells (PTEC), whereas bradykinin (BK) upregulated IL-6, CCL-2 and TGF-beta mRNA. Glucose 26-33 C-C motif chemokine ligand 2 Homo sapiens 290-295 19923143-5 2010 Inhibition of MAPK p42/p44 by PD98059 partially reduced HG and BK induction of IL-6, CCL-2 and TGF-beta, whereas inhibition of PKC by staurosporine partially reduced HG- but not BK-induced overexpression of these cytokines and that of VEGF. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 30-37 C-C motif chemokine ligand 2 Homo sapiens 85-90 19923143-6 2010 Staurosporine and PD98059 synergistically reduced the effect of HG on IL-6, CCL-2 and TGF-beta expression. Staurosporine 0-13 C-C motif chemokine ligand 2 Homo sapiens 76-81 19923143-6 2010 Staurosporine and PD98059 synergistically reduced the effect of HG on IL-6, CCL-2 and TGF-beta expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 18-25 C-C motif chemokine ligand 2 Homo sapiens 76-81 19923143-9 2010 The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist, rosiglitazone, attenuated HG-induced PKC but not HG- or BK- induced MAPK p42/44 activation and reduced HG-stimulated VEGF, along with IL-6, CCL-2 and TGF-beta secretion. Rosiglitazone 75-88 C-C motif chemokine ligand 2 Homo sapiens 215-220 19655299-7 2010 Addition of ROC at different concentrations together with IFN-gamma and histamine induced a dose-dependent inhibition of ICAM-1 expression and MCP-1 and IL-8 release. Saquinavir 12-15 C-C motif chemokine ligand 2 Homo sapiens 143-148 19655299-7 2010 Addition of ROC at different concentrations together with IFN-gamma and histamine induced a dose-dependent inhibition of ICAM-1 expression and MCP-1 and IL-8 release. Histamine 72-81 C-C motif chemokine ligand 2 Homo sapiens 143-148 20370601-6 2010 By contrast, broader-spectrum cdk inhibitors, such as roscovitine, 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (DRB), and flavopiridol, inhibited MCP-1/CCL2 induction by Tat. Dichlororibofuranosylbenzimidazole 67-115 C-C motif chemokine ligand 2 Homo sapiens 151-156 20370601-6 2010 By contrast, broader-spectrum cdk inhibitors, such as roscovitine, 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (DRB), and flavopiridol, inhibited MCP-1/CCL2 induction by Tat. Dichlororibofuranosylbenzimidazole 67-115 C-C motif chemokine ligand 2 Homo sapiens 157-161 20370601-6 2010 By contrast, broader-spectrum cdk inhibitors, such as roscovitine, 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (DRB), and flavopiridol, inhibited MCP-1/CCL2 induction by Tat. alvocidib 127-139 C-C motif chemokine ligand 2 Homo sapiens 151-156 20370601-6 2010 By contrast, broader-spectrum cdk inhibitors, such as roscovitine, 5,6-dichloro-1-beta-d-ribofuranosylbenzimidazole (DRB), and flavopiridol, inhibited MCP-1/CCL2 induction by Tat. alvocidib 127-139 C-C motif chemokine ligand 2 Homo sapiens 157-161 19866475-0 2010 CCL2 is induced by chemotherapy and protects prostate cancer cells from docetaxel-induced cytotoxicity. Docetaxel 72-81 C-C motif chemokine ligand 2 Homo sapiens 0-4 19866475-2 2010 In this study, we identified a docetaxel-induced resistance mechanism centered on CCL2. Docetaxel 31-40 C-C motif chemokine ligand 2 Homo sapiens 82-86 19866475-6 2010 Docetaxel increased CCL2 expression in prostate cancer cell lines in vitro. Docetaxel 0-9 C-C motif chemokine ligand 2 Homo sapiens 20-24 19866475-7 2010 CCL2-specific siRNA inhibited LNCaP and LAPC4 cell proliferation and enhanced the growth inhibitory effect of low-dose docetaxel. Docetaxel 119-128 C-C motif chemokine ligand 2 Homo sapiens 0-4 19866475-8 2010 In contrast, overexpression of CCL2 or recombinant CCL2 protein stimulated prostate cancer cell proliferation and rescued cells from docetaxel-induced cytotoxicity. Docetaxel 133-142 C-C motif chemokine ligand 2 Homo sapiens 31-35 19866475-8 2010 In contrast, overexpression of CCL2 or recombinant CCL2 protein stimulated prostate cancer cell proliferation and rescued cells from docetaxel-induced cytotoxicity. Docetaxel 133-142 C-C motif chemokine ligand 2 Homo sapiens 51-55 19866475-9 2010 This protective effect of CCL2 was associated with activation of the ERK/MAP kinase and PI3K/AKT, inhibition of docetaxel-induced Bcl2 phosphorylation at serine 70, phosphorylation of Bad, and activation of caspase-3. Docetaxel 112-121 C-C motif chemokine ligand 2 Homo sapiens 26-30 19866475-9 2010 This protective effect of CCL2 was associated with activation of the ERK/MAP kinase and PI3K/AKT, inhibition of docetaxel-induced Bcl2 phosphorylation at serine 70, phosphorylation of Bad, and activation of caspase-3. Serine 154-160 C-C motif chemokine ligand 2 Homo sapiens 26-30 19958764-6 2010 We also demonstrated that BHMC has a very minimal effect upon iNOS activity with no effect at all upon the secretion of PGE(2) but has a strong inhibitory effect upon MCP-1 and IL-10 secretion and gene expression. bhmc 26-30 C-C motif chemokine ligand 2 Homo sapiens 167-172 19866475-10 2010 The addition of a PI3K/AKT inhibitor Ly294002 reversed the CCL2 protection and was additive to docetaxel-induced toxicity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 37-45 C-C motif chemokine ligand 2 Homo sapiens 59-63 19866475-11 2010 CONCLUSION: These results support a mechanism of chemotherapy resistance mediated by cellular stress responses involving the induction of CCL2 expression and suggest that inhibiting CCL2 activity could enhance therapeutic responses to taxane-based therapy. taxane 235-241 C-C motif chemokine ligand 2 Homo sapiens 138-142 19866475-11 2010 CONCLUSION: These results support a mechanism of chemotherapy resistance mediated by cellular stress responses involving the induction of CCL2 expression and suggest that inhibiting CCL2 activity could enhance therapeutic responses to taxane-based therapy. taxane 235-241 C-C motif chemokine ligand 2 Homo sapiens 182-186 20054232-4 2010 The reduced adhesion by GFW correlated with the suppressed expression of MCP-1 and IL-8, the major IBD-associated chemokines. ethyl 2-[4-[4-(3-methylbutylsulfamoyl)phenyl]-1,3-thiazol-2-yl]ethanoate 24-27 C-C motif chemokine ligand 2 Homo sapiens 73-78 20054232-9 2010 The results suggest that GFW ameliorates colon inflammation by suppressing production of TNF-alpha as well as its signaling through NF-kappaB leading to the expression of inflammatory chemokines, MCP-1 and IL-8. ethyl 2-[4-[4-(3-methylbutylsulfamoyl)phenyl]-1,3-thiazol-2-yl]ethanoate 25-28 C-C motif chemokine ligand 2 Homo sapiens 196-201 19933497-0 2010 Regulation of monocyte chemotactic protein-1 expression in human endometrial endothelial cells by sex steroids: a potential mechanism for leukocyte recruitment in endometriosis. Steroids 102-110 C-C motif chemokine ligand 2 Homo sapiens 14-44 19933497-5 2010 The effects of estradiol (5 x 10(- 8) mol/L), progesterone (10(-7) mol/L), or both on MCP-1 messenger RNA (mRNA) and protein levels were analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis and enzyme-linked immunosorbent serologic assay (ELISA), respectively. Estradiol 15-24 C-C motif chemokine ligand 2 Homo sapiens 86-91 19933497-5 2010 The effects of estradiol (5 x 10(- 8) mol/L), progesterone (10(-7) mol/L), or both on MCP-1 messenger RNA (mRNA) and protein levels were analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis and enzyme-linked immunosorbent serologic assay (ELISA), respectively. Progesterone 46-58 C-C motif chemokine ligand 2 Homo sapiens 86-91 19933497-7 2010 However, we observed that the sex steroid treatment stimulated MCP-1 mRNA and protein expression in HEECs from women with endometriosis (P < .05). Steroids 34-41 C-C motif chemokine ligand 2 Homo sapiens 63-68 19910630-9 2010 In the presence of 2% and 4% HES 200/0.5 in 98% (96%) medium over a stimulation time period of 10 h and 18 h, the MCP-1 concentration was decreased between 26% and 56% (P < 0.05). Hydroxyethyl Starch Derivatives 29-32 C-C motif chemokine ligand 2 Homo sapiens 114-119 20102702-5 2010 Surprisingly, the variant with deletion of amino acids 220-320 (FliCDelta220-320) induced higher production of IL-8, MCP-1, and TNF-alpha, and showed higher mucosal adjuvancy than full-length FliC flagellin. flicdelta220 64-76 C-C motif chemokine ligand 2 Homo sapiens 117-122 19926874-6 2010 In contrast, secondary necrotic VSMCs release both IL-1alpha and caspase-activated IL-1beta, augmenting IL-6 and MCP-1 production. vsmcs 32-37 C-C motif chemokine ligand 2 Homo sapiens 113-118 19939912-8 2010 Selective GR stimulation of white adipocytes with dexamethasone inhibited the expression of interleukin 6 (IL6), monocyte chemoattractant protein-1 (MCP1 or CCL2 as listed in the MGI Database), tumour necrosis factor-alpha, chemerin and leptin. Dexamethasone 50-63 C-C motif chemokine ligand 2 Homo sapiens 113-147 20029197-1 2010 BACKGROUND: The -928 guanine (G)/cytosine (C) and -362 G/C single-nucleotide polymorphisms (SNPs) in the proximal promoter region of the monocyte chemoattractant protein 1 gene have been associated with an increased risk for intimal medial thickness and carotid atherosclerosis, respectively. Guanine 21-28 C-C motif chemokine ligand 2 Homo sapiens 137-171 19890837-7 2010 TRPM6 mRNA was also rapidly upregulated or downregulated in HC11 cells deprived of magnesium or in low-magnesium cells re-added with magnesium, respectively. Magnesium 83-92 C-C motif chemokine ligand 2 Homo sapiens 60-64 19939912-8 2010 Selective GR stimulation of white adipocytes with dexamethasone inhibited the expression of interleukin 6 (IL6), monocyte chemoattractant protein-1 (MCP1 or CCL2 as listed in the MGI Database), tumour necrosis factor-alpha, chemerin and leptin. Dexamethasone 50-63 C-C motif chemokine ligand 2 Homo sapiens 149-153 19939912-8 2010 Selective GR stimulation of white adipocytes with dexamethasone inhibited the expression of interleukin 6 (IL6), monocyte chemoattractant protein-1 (MCP1 or CCL2 as listed in the MGI Database), tumour necrosis factor-alpha, chemerin and leptin. Dexamethasone 50-63 C-C motif chemokine ligand 2 Homo sapiens 157-161 19939912-10 2010 Furthermore, in the presence of an acute GR knockdown as well as in GR knockout adipocytes, corticosterone increased the gene expression of the pro-inflammatory adipokines IL6 and MCP1. Corticosterone 92-106 C-C motif chemokine ligand 2 Homo sapiens 180-184 19864434-3 2010 Here we show that MCP-1 mediates activation of the CCR2 receptor and inhibits coexpressed N-type calcium channels in tsA-201 cells via a voltage-dependent pathway. trichostatin A 117-120 C-C motif chemokine ligand 2 Homo sapiens 18-23 19864434-6 2010 Whole-cell T-type calcium currents in acutely dissociated dorsal root ganglia neurons are effectively inhibited by MCP-1, consistent with the notion that these cells express Ca(v)3.2. Calcium 18-25 C-C motif chemokine ligand 2 Homo sapiens 115-120 20149224-1 2010 INTRODUCTION: To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL). Uric Acid 55-58 C-C motif chemokine ligand 2 Homo sapiens 100-134 19877654-1 2010 Dichlorocarbene (CCl(2)), generated by laser flash photolysis of dichlorodiazirine, formed pi- and O-ylidic complexes with aromatic ethers such as anisole, 1,3-dimethoxybenzene, 1,3,5-trimethoxybenzene, dibenzofuran, and dibenzo-18-crown-6 and with the aromatic ester phenyl acetate. dichlorocarbene 0-15 C-C motif chemokine ligand 2 Homo sapiens 17-23 19877654-1 2010 Dichlorocarbene (CCl(2)), generated by laser flash photolysis of dichlorodiazirine, formed pi- and O-ylidic complexes with aromatic ethers such as anisole, 1,3-dimethoxybenzene, 1,3,5-trimethoxybenzene, dibenzofuran, and dibenzo-18-crown-6 and with the aromatic ester phenyl acetate. dichlorodiazirine 65-82 C-C motif chemokine ligand 2 Homo sapiens 17-23 19877654-1 2010 Dichlorocarbene (CCl(2)), generated by laser flash photolysis of dichlorodiazirine, formed pi- and O-ylidic complexes with aromatic ethers such as anisole, 1,3-dimethoxybenzene, 1,3,5-trimethoxybenzene, dibenzofuran, and dibenzo-18-crown-6 and with the aromatic ester phenyl acetate. o-ylidic 99-107 C-C motif chemokine ligand 2 Homo sapiens 17-23 19877654-1 2010 Dichlorocarbene (CCl(2)), generated by laser flash photolysis of dichlorodiazirine, formed pi- and O-ylidic complexes with aromatic ethers such as anisole, 1,3-dimethoxybenzene, 1,3,5-trimethoxybenzene, dibenzofuran, and dibenzo-18-crown-6 and with the aromatic ester phenyl acetate. aromatic 123-131 C-C motif chemokine ligand 2 Homo sapiens 17-23 19877654-1 2010 Dichlorocarbene (CCl(2)), generated by laser flash photolysis of dichlorodiazirine, formed pi- and O-ylidic complexes with aromatic ethers such as anisole, 1,3-dimethoxybenzene, 1,3,5-trimethoxybenzene, dibenzofuran, and dibenzo-18-crown-6 and with the aromatic ester phenyl acetate. Ethers 132-138 C-C motif chemokine ligand 2 Homo sapiens 17-23 19877654-1 2010 Dichlorocarbene (CCl(2)), generated by laser flash photolysis of dichlorodiazirine, formed pi- and O-ylidic complexes with aromatic ethers such as anisole, 1,3-dimethoxybenzene, 1,3,5-trimethoxybenzene, dibenzofuran, and dibenzo-18-crown-6 and with the aromatic ester phenyl acetate. anisole 147-154 C-C motif chemokine ligand 2 Homo sapiens 17-23 19877654-1 2010 Dichlorocarbene (CCl(2)), generated by laser flash photolysis of dichlorodiazirine, formed pi- and O-ylidic complexes with aromatic ethers such as anisole, 1,3-dimethoxybenzene, 1,3,5-trimethoxybenzene, dibenzofuran, and dibenzo-18-crown-6 and with the aromatic ester phenyl acetate. 1,3-dimethoxybenzene 156-176 C-C motif chemokine ligand 2 Homo sapiens 17-23 19877654-1 2010 Dichlorocarbene (CCl(2)), generated by laser flash photolysis of dichlorodiazirine, formed pi- and O-ylidic complexes with aromatic ethers such as anisole, 1,3-dimethoxybenzene, 1,3,5-trimethoxybenzene, dibenzofuran, and dibenzo-18-crown-6 and with the aromatic ester phenyl acetate. 1,3,5-trimethoxybenzene 178-201 C-C motif chemokine ligand 2 Homo sapiens 17-23 19877654-1 2010 Dichlorocarbene (CCl(2)), generated by laser flash photolysis of dichlorodiazirine, formed pi- and O-ylidic complexes with aromatic ethers such as anisole, 1,3-dimethoxybenzene, 1,3,5-trimethoxybenzene, dibenzofuran, and dibenzo-18-crown-6 and with the aromatic ester phenyl acetate. dibenzofuran 203-215 C-C motif chemokine ligand 2 Homo sapiens 17-23 19877654-1 2010 Dichlorocarbene (CCl(2)), generated by laser flash photolysis of dichlorodiazirine, formed pi- and O-ylidic complexes with aromatic ethers such as anisole, 1,3-dimethoxybenzene, 1,3,5-trimethoxybenzene, dibenzofuran, and dibenzo-18-crown-6 and with the aromatic ester phenyl acetate. dibenzo-18-crown-6 221-239 C-C motif chemokine ligand 2 Homo sapiens 17-23 19877654-1 2010 Dichlorocarbene (CCl(2)), generated by laser flash photolysis of dichlorodiazirine, formed pi- and O-ylidic complexes with aromatic ethers such as anisole, 1,3-dimethoxybenzene, 1,3,5-trimethoxybenzene, dibenzofuran, and dibenzo-18-crown-6 and with the aromatic ester phenyl acetate. aromatic ester phenyl acetate 253-282 C-C motif chemokine ligand 2 Homo sapiens 17-23 19877654-2 2010 These complexes were visualized by UV-vis spectroscopy, and they retarded the addition of CCl(2) to tetramethylethylene by factors of 18-152. 2,3-dimethyl-2-butene 100-119 C-C motif chemokine ligand 2 Homo sapiens 90-95 19877654-4 2010 Complexes were not observed between CCl(2) and simple, nonaromatic ethers such as THF, dioxane, or 18-crown-6, nor did these ethers much affect the addition rate of CCl(2) to tetramethylethylene. Ethers 125-131 C-C motif chemokine ligand 2 Homo sapiens 165-171 19877654-5 2010 Computations also suggested that pi-complexes of CCl(2) and, e.g., mesitylene and durene, were energetically reasonable transients. mesitylene 67-77 C-C motif chemokine ligand 2 Homo sapiens 49-55 19877654-5 2010 Computations also suggested that pi-complexes of CCl(2) and, e.g., mesitylene and durene, were energetically reasonable transients. durene 82-88 C-C motif chemokine ligand 2 Homo sapiens 49-55 19877654-6 2010 Although these species were not detected spectroscopically, the aromatic compounds did slow the addition of CCl(2) to tetramethylethylene by factors of 15 and 31, respectively. 2,3-dimethyl-2-butene 118-137 C-C motif chemokine ligand 2 Homo sapiens 108-114 20389059-0 2010 Indoxyl sulfate upregulates expression of ICAM-1 and MCP-1 by oxidative stress-induced NF-kappaB activation. Indican 0-15 C-C motif chemokine ligand 2 Homo sapiens 53-58 20389059-2 2010 The present study aimed to determine whether indoxyl sulfate increases the expression of intercellular adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein-1 (MCP-1) by reactive oxygen species (ROS)-induced activation of nuclear factor-kappaB (NF-kappaB) in vascular endothelial cells. Indican 45-60 C-C motif chemokine ligand 2 Homo sapiens 136-166 20389059-2 2010 The present study aimed to determine whether indoxyl sulfate increases the expression of intercellular adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein-1 (MCP-1) by reactive oxygen species (ROS)-induced activation of nuclear factor-kappaB (NF-kappaB) in vascular endothelial cells. Indican 45-60 C-C motif chemokine ligand 2 Homo sapiens 168-173 20389059-2 2010 The present study aimed to determine whether indoxyl sulfate increases the expression of intercellular adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein-1 (MCP-1) by reactive oxygen species (ROS)-induced activation of nuclear factor-kappaB (NF-kappaB) in vascular endothelial cells. Reactive Oxygen Species 178-201 C-C motif chemokine ligand 2 Homo sapiens 136-166 20389059-2 2010 The present study aimed to determine whether indoxyl sulfate increases the expression of intercellular adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein-1 (MCP-1) by reactive oxygen species (ROS)-induced activation of nuclear factor-kappaB (NF-kappaB) in vascular endothelial cells. Reactive Oxygen Species 178-201 C-C motif chemokine ligand 2 Homo sapiens 168-173 20389059-2 2010 The present study aimed to determine whether indoxyl sulfate increases the expression of intercellular adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein-1 (MCP-1) by reactive oxygen species (ROS)-induced activation of nuclear factor-kappaB (NF-kappaB) in vascular endothelial cells. Reactive Oxygen Species 203-206 C-C motif chemokine ligand 2 Homo sapiens 136-166 20389059-2 2010 The present study aimed to determine whether indoxyl sulfate increases the expression of intercellular adhesion molecule-1 (ICAM-1) and monocyte chemotactic protein-1 (MCP-1) by reactive oxygen species (ROS)-induced activation of nuclear factor-kappaB (NF-kappaB) in vascular endothelial cells. Reactive Oxygen Species 203-206 C-C motif chemokine ligand 2 Homo sapiens 168-173 20389059-6 2010 RESULTS: Indoxyl sulfate significantly increased the mRNA expression of ICAM-1 and MCP-1 in HUVEC in a time- and concentration-dependent manner. Indican 9-24 C-C motif chemokine ligand 2 Homo sapiens 83-88 20389059-7 2010 Inhibitors of NF-kappaB (ammonium pyrrolidinedithiocarbamate and isohelenin) and an antioxidant (N-acetyl-L-cysteine) suppressed the indoxyl sulfate-induced expression of ICAM-1 and MCP-1 in HUVEC. pyrrolidine dithiocarbamic acid 25-60 C-C motif chemokine ligand 2 Homo sapiens 182-187 20389059-7 2010 Inhibitors of NF-kappaB (ammonium pyrrolidinedithiocarbamate and isohelenin) and an antioxidant (N-acetyl-L-cysteine) suppressed the indoxyl sulfate-induced expression of ICAM-1 and MCP-1 in HUVEC. isohelenin 65-75 C-C motif chemokine ligand 2 Homo sapiens 182-187 20389059-7 2010 Inhibitors of NF-kappaB (ammonium pyrrolidinedithiocarbamate and isohelenin) and an antioxidant (N-acetyl-L-cysteine) suppressed the indoxyl sulfate-induced expression of ICAM-1 and MCP-1 in HUVEC. Acetylcysteine 97-116 C-C motif chemokine ligand 2 Homo sapiens 182-187 20389059-7 2010 Inhibitors of NF-kappaB (ammonium pyrrolidinedithiocarbamate and isohelenin) and an antioxidant (N-acetyl-L-cysteine) suppressed the indoxyl sulfate-induced expression of ICAM-1 and MCP-1 in HUVEC. Indican 133-148 C-C motif chemokine ligand 2 Homo sapiens 182-187 20389059-9 2010 CONCLUSIONS: Indoxyl sulfate upregulates the expression of ICAM-1 and MCP-1 by ROS-induced activation of NF-kappaB in vascular endothelial cells. Indican 13-28 C-C motif chemokine ligand 2 Homo sapiens 70-75 20389059-9 2010 CONCLUSIONS: Indoxyl sulfate upregulates the expression of ICAM-1 and MCP-1 by ROS-induced activation of NF-kappaB in vascular endothelial cells. Reactive Oxygen Species 79-82 C-C motif chemokine ligand 2 Homo sapiens 70-75 20389059-10 2010 Thus, indoxyl sulfate may play an important role in the development of CVD in CKD by increasing the endothelial expression of ICAM-1 and MCP-1. Indican 6-21 C-C motif chemokine ligand 2 Homo sapiens 137-142 20149224-0 2010 High-density lipoproteins downregulate CCL2 production in human fibroblast-like synoviocytes stimulated by urate crystals. Uric Acid 107-112 C-C motif chemokine ligand 2 Homo sapiens 39-43 20149224-1 2010 INTRODUCTION: To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL). Uric Acid 37-53 C-C motif chemokine ligand 2 Homo sapiens 94-98 20149224-1 2010 INTRODUCTION: To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL). Uric Acid 37-53 C-C motif chemokine ligand 2 Homo sapiens 100-134 20149224-1 2010 INTRODUCTION: To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL). Uric Acid 37-53 C-C motif chemokine ligand 2 Homo sapiens 136-141 20149224-1 2010 INTRODUCTION: To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL). Uric Acid 55-58 C-C motif chemokine ligand 2 Homo sapiens 94-98 20149224-1 2010 INTRODUCTION: To investigate whether monosodium urate (MSU) crystals induce the production of CCL2 (monocyte chemoattractant protein-1; MCP-1) in human fibroblast-like synoviocytes (FLS) and whether this mechanism would be affected by high-density lipoproteins (HDL). Uric Acid 55-58 C-C motif chemokine ligand 2 Homo sapiens 136-141 20091676-2 2010 The thioester-peptide segment was synthesized using the sulfonamide safety-catch linker and 9-fluorenylmethoxycarbonyl (Fmoc) SPPS, and pseudoproline dipeptides were used to facilitate the synthesis of both CCL2 fragments. pseudoproline 136-149 C-C motif chemokine ligand 2 Homo sapiens 207-211 20606305-8 2010 Azelnidipine significantly diminished the PHA-induced rise of [Ca(2+)](i), and the production of MCP-1 and TNF-alpha. azelnidipine 0-12 C-C motif chemokine ligand 2 Homo sapiens 97-102 20004647-7 2010 MK0812 selectively reduced the peripheral blood monocyte frequency, and caused an elevation in the CCR2 ligand CCL2. MK-0812 0-6 C-C motif chemokine ligand 2 Homo sapiens 111-115 21215246-4 2010 We demonstrated, by using in vivo and in vitro approaches, that SDF-1 and MCP-1 can modulate DA neurotransmission in the nigro-striatal pathway, modifying the electrophysiological state of the neuron and DA release, through their cognate receptors. Dopamine 93-95 C-C motif chemokine ligand 2 Homo sapiens 74-79 21215246-5 2010 These effects are produced through N-type high voltage-activated calcium currents for SDF-1 and potassium channels for MCP-1. Calcium 65-72 C-C motif chemokine ligand 2 Homo sapiens 119-124 20091676-3 2010 After assembly of the full-length peptide chain by NCL, a glutathione redox buffer was used to fold and oxidize the CCL2 protein. glutathione redox buffer 58-82 C-C motif chemokine ligand 2 Homo sapiens 116-120 21526274-11 2010 Sodium nitroprusside also caused a reduction in monocyte chemotactic protein-1 secretion by both cell types. Nitroprusside 0-20 C-C motif chemokine ligand 2 Homo sapiens 48-78 20719078-10 2010 The production of cytokine/chemokine including IL-1beta, TNF-alpha, IFN-gamma, IL-6, IL-8, MIP-1beta, MCP-1, and RANTES but not tissue factor from the OptiPrep group was significantly lower during 48-h culture after isolation. iodixanol 151-159 C-C motif chemokine ligand 2 Homo sapiens 102-107 20332635-6 2010 In addition, DHMEQ induces a significant dose-dependent decrease in ICAM expression, MCP-1, RANTES, and IL-8 release. dehydroxymethylepoxyquinomicin 13-18 C-C motif chemokine ligand 2 Homo sapiens 85-90 21173461-0 2010 Reactions between rubidium atoms and C6F6, C2Cl4, C2HCl3, CH2=CCl2 or trans-C2H2Cl2 in crossed molecular beams. Rubidium 18-26 C-C motif chemokine ligand 2 Homo sapiens 62-66 19906815-0 2010 Lysophosphatidic acid up-regulates expression of growth-regulated oncogene-alpha, interleukin-8, and monocyte chemoattractant protein-1 in human first-trimester trophoblasts: possible roles in angiogenesis and immune regulation. lysophosphatidic acid 0-21 C-C motif chemokine ligand 2 Homo sapiens 101-135 20843508-7 2010 Morphine treatment inhibited early recruitment of both neutrophils and monocytes towards an inflammatory signal with a significant decrease in the monocyte chemoattractant MCP-1. Morphine 0-8 C-C motif chemokine ligand 2 Homo sapiens 172-177 19906815-13 2010 LPA-induced GRO-alpha and MCP-1 incited chemotaxis of natural killer cells and monocytes. lysophosphatidic acid 0-3 C-C motif chemokine ligand 2 Homo sapiens 26-31 21173461-0 2010 Reactions between rubidium atoms and C6F6, C2Cl4, C2HCl3, CH2=CCl2 or trans-C2H2Cl2 in crossed molecular beams. Methylene 58-61 C-C motif chemokine ligand 2 Homo sapiens 62-66 19766691-0 2010 Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 58-63 19766691-0 2010 Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity. Tetradecanoylphorbol Acetate 18-43 C-C motif chemokine ligand 2 Homo sapiens 58-63 19766691-0 2010 Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity. Tetradecanoylphorbol Acetate 45-48 C-C motif chemokine ligand 2 Homo sapiens 58-63 20653997-2 2010 This study focused on the ability of diplacone to modulate the gene expression of pro-inflammatory tumour necrosis factor alpha and monocyte chemoattractant protein 1, and of anti-inflammatory zinc finger protein 36. diplacone 37-46 C-C motif chemokine ligand 2 Homo sapiens 132-166 20653997-6 2010 In this model, diplacone significantly down-regulated the expression of tumour necrosis factor alpha and monocyte chemoattractant protein 1 and up-regulated the zinc finger protein 36 expression. diplacone 15-24 C-C motif chemokine ligand 2 Homo sapiens 105-139 19766691-3 2010 We found that curcumin, a natural biologically active compound extracted from rhizomes of Curcuma species, significantly inhibited the PMA-induced increase in MCP-1 expression and secretion. Curcumin 14-22 C-C motif chemokine ligand 2 Homo sapiens 159-164 19766691-3 2010 We found that curcumin, a natural biologically active compound extracted from rhizomes of Curcuma species, significantly inhibited the PMA-induced increase in MCP-1 expression and secretion. Tetradecanoylphorbol Acetate 135-138 C-C motif chemokine ligand 2 Homo sapiens 159-164 19766691-4 2010 These effects of curcumin are dose dependent and correlate with the suppression of MCP-1 mRNA expression levels. Curcumin 17-25 C-C motif chemokine ligand 2 Homo sapiens 83-88 19766691-6 2010 Therefore, one possible anti-inflammatory mechanism of curcumin may be to inhibit the secretions of inflammatory MCP-1 chemokine. Curcumin 55-63 C-C motif chemokine ligand 2 Homo sapiens 113-118 19460789-4 2009 The muscarinic receptor agonists carbachol and methacholine both induced modest effects on basal interleukin (IL)-8 and -6 secretion, whereas the secretion of RANTES, eotaxin, vascular endothelial growth factor-A and monocyte chemoattractant protein-1 was not affected. Carbachol 33-42 C-C motif chemokine ligand 2 Homo sapiens 217-251 20360622-6 2010 In all groups of dyslipidemic patients, micronized fenofibrate reduced monocyte release of interleukin-1beta and MCP-1, and this effect was stronger in prediabetic subjects. Fenofibrate 51-62 C-C motif chemokine ligand 2 Homo sapiens 113-118 19800902-3 2010 Using in vitro assays, we have shown in a previous study that human bronchial epithelial cells release inflammatory mediators such as the cytokine monocyte chemoattractant protein-1 (MCP-1) in response to chlorobenzene. chlorobenzene 205-218 C-C motif chemokine ligand 2 Homo sapiens 147-181 19800902-3 2010 Using in vitro assays, we have shown in a previous study that human bronchial epithelial cells release inflammatory mediators such as the cytokine monocyte chemoattractant protein-1 (MCP-1) in response to chlorobenzene. chlorobenzene 205-218 C-C motif chemokine ligand 2 Homo sapiens 183-188 19800902-8 2010 However, in the presence of the antioxidants N-(2-mercaptopropionyl)-glycine (MPG) or bucillamine, chlorobenzene-induced upregulation of marker proteins and release of the inflammatory mediator MCP-1 are suppressed. Tiopronin 45-76 C-C motif chemokine ligand 2 Homo sapiens 194-199 19800902-8 2010 However, in the presence of the antioxidants N-(2-mercaptopropionyl)-glycine (MPG) or bucillamine, chlorobenzene-induced upregulation of marker proteins and release of the inflammatory mediator MCP-1 are suppressed. bucillamine 86-97 C-C motif chemokine ligand 2 Homo sapiens 194-199 19800902-8 2010 However, in the presence of the antioxidants N-(2-mercaptopropionyl)-glycine (MPG) or bucillamine, chlorobenzene-induced upregulation of marker proteins and release of the inflammatory mediator MCP-1 are suppressed. chlorobenzene 99-112 C-C motif chemokine ligand 2 Homo sapiens 194-199 20002897-9 2010 DEX dose dependently down-regulated basal and MMC-induced interleukin-8 and monocyte chemoattractant protein-1 mRNA expression and protein secretion. Dexamethasone 0-3 C-C motif chemokine ligand 2 Homo sapiens 76-110 20002897-11 2010 These suggested that DEX may inhibit MMC-induced interleukin-8 and monocyte chemoattractant protein-1 by up-regulating MKP-1 expression, which subsequently deactivated p38 and Jun N-terminal kinases activation. Dexamethasone 21-24 C-C motif chemokine ligand 2 Homo sapiens 67-101 20002897-11 2010 These suggested that DEX may inhibit MMC-induced interleukin-8 and monocyte chemoattractant protein-1 by up-regulating MKP-1 expression, which subsequently deactivated p38 and Jun N-terminal kinases activation. Mitomycin 37-40 C-C motif chemokine ligand 2 Homo sapiens 67-101 19912233-4 2009 EXPERIMENTAL APPROACH: We used a human monocyte cell line (THP-1) to analyse the effects of treatment with EGCG under non-cytotoxic conditions on the expression levels of the monocyte chemotactic protein-1 (MCP-1) and of the MCP-1 receptor (CCR2) and on the activation of beta1 integrin. epigallocatechin gallate 107-111 C-C motif chemokine ligand 2 Homo sapiens 175-205 19912233-4 2009 EXPERIMENTAL APPROACH: We used a human monocyte cell line (THP-1) to analyse the effects of treatment with EGCG under non-cytotoxic conditions on the expression levels of the monocyte chemotactic protein-1 (MCP-1) and of the MCP-1 receptor (CCR2) and on the activation of beta1 integrin. epigallocatechin gallate 107-111 C-C motif chemokine ligand 2 Homo sapiens 207-212 19755933-5 2010 On d 3, MCP 1 was higher and RANTES lower among infants with early prolonged O2 exposure. Oxygen 77-79 C-C motif chemokine ligand 2 Homo sapiens 8-13 19755933-6 2010 After adjusting for covariates, prolonged early O2 exposure retained a statistically significant association with higher MCP 1 on d 3 (p = 0.003). Oxygen 48-50 C-C motif chemokine ligand 2 Homo sapiens 121-126 19755933-7 2010 The consistent association between O2 exposure and MCP 1 among extremely preterm infants suggests that further investigation of its role in oxidative injury is warranted. Oxygen 35-37 C-C motif chemokine ligand 2 Homo sapiens 51-56 20025541-9 2010 The iodide-induced increase in CCL2 was greater in thyroid follicles obtained from thyroid gland that had been moderately infiltrated with the immunocompetent cells. Iodides 4-10 C-C motif chemokine ligand 2 Homo sapiens 31-35 20025541-10 2010 CONCLUSION: We have demonstrated that iodide stimulates thyroid follicular cells to produce chemokines, particularly CCL2, CXCL8, and CXCL14. Iodides 38-44 C-C motif chemokine ligand 2 Homo sapiens 117-121 20056091-7 2010 The level of MCP-1 in serum of RA patieuts was positively correlated with IgG, IgM, and gamma-G. Radium 31-33 C-C motif chemokine ligand 2 Homo sapiens 13-18 19850013-4 2009 Exposure of HEC for 48h to AGE-LDL in 5mM glucose induced an increase of RAGE expression (50%), NADPHox activity (107%), p22(phox) and NOX4 mRNA (50% and 188%, respectively) and MCP-1 expression (80%). Glucose 42-49 C-C motif chemokine ligand 2 Homo sapiens 178-183 19850013-6 2009 The addition of 25mM glucose in the culture medium enhanced the effect of AGE-LDL, but also of nLDL, on RAGE, p22(phox), NOX4, p67(phox), and MCP-1 gene expression. Glucose 21-28 C-C motif chemokine ligand 2 Homo sapiens 142-147 19912233-6 2009 KEY RESULTS: Treatment of THP-1 cells with EGCG decreased MCP-1 and CCR2 gene expression, together with MCP-1 secretion and CCR2 expression at the cell surface. epigallocatechin gallate 43-47 C-C motif chemokine ligand 2 Homo sapiens 58-63 19912233-6 2009 KEY RESULTS: Treatment of THP-1 cells with EGCG decreased MCP-1 and CCR2 gene expression, together with MCP-1 secretion and CCR2 expression at the cell surface. epigallocatechin gallate 43-47 C-C motif chemokine ligand 2 Homo sapiens 104-109 19912233-8 2009 The effects on these molecular targets were in agreement with the EGCG-induced inhibition of THP-1 migration in response to MCP-1 and adhesion to fibronectin. epigallocatechin gallate 66-70 C-C motif chemokine ligand 2 Homo sapiens 124-129 19558503-13 2009 Induction of MxA, CCL2, CXCL10 and IFI27 was reduced in patients with low NAb levels and lost in patients with intermediate/high NAb levels. nab 74-77 C-C motif chemokine ligand 2 Homo sapiens 18-22 19460789-4 2009 The muscarinic receptor agonists carbachol and methacholine both induced modest effects on basal interleukin (IL)-8 and -6 secretion, whereas the secretion of RANTES, eotaxin, vascular endothelial growth factor-A and monocyte chemoattractant protein-1 was not affected. Methacholine Chloride 47-59 C-C motif chemokine ligand 2 Homo sapiens 217-251 20374368-9 2009 Urinary MCP-1 correlated positively with proteinuria, and negatively with creatinine clearance and hemoglobin; thus, urinary MCP-1 correlates with the severity of nephritis. Creatinine 74-84 C-C motif chemokine ligand 2 Homo sapiens 125-130 19885628-8 2009 In culture media, the increase in MCP-1 detected after LPS stimulation was significantly attenuated after pre-treatment with AdG. Ala-Asp-Gly 125-128 C-C motif chemokine ligand 2 Homo sapiens 34-39 19885628-12 2009 Both AdG and AdFl exert anti-inflammatory activity suppressing IL-6 and MCP-1 production from inflamed adipocytes. Ala-Asp-Gly 5-8 C-C motif chemokine ligand 2 Homo sapiens 72-77 19915063-5 2009 We found that iloprost inhibited IFN-gamma- and IL-6-induced MCP-1, IL-8, RANTES, and TNF-alpha production in monocytes, indicating wide-ranging anti-inflammatory action. Iloprost 14-22 C-C motif chemokine ligand 2 Homo sapiens 61-66 19885629-9 2009 On the other hand, taxol-induced up-regulation of MCP-1 was reduced in cells treated with U73122, an inhibitor of phospholipase C (PLC), and ectopic expression of PLC-gamma1 increased the expression of MCP-1 in taxol-treated MCF-7 cells, indicating that PLC-gamma1 functions as a positive regulator in taxol-induced MCP-1 expression. Paclitaxel 19-24 C-C motif chemokine ligand 2 Homo sapiens 202-207 19885629-9 2009 On the other hand, taxol-induced up-regulation of MCP-1 was reduced in cells treated with U73122, an inhibitor of phospholipase C (PLC), and ectopic expression of PLC-gamma1 increased the expression of MCP-1 in taxol-treated MCF-7 cells, indicating that PLC-gamma1 functions as a positive regulator in taxol-induced MCP-1 expression. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 90-96 C-C motif chemokine ligand 2 Homo sapiens 202-207 19885629-9 2009 On the other hand, taxol-induced up-regulation of MCP-1 was reduced in cells treated with U73122, an inhibitor of phospholipase C (PLC), and ectopic expression of PLC-gamma1 increased the expression of MCP-1 in taxol-treated MCF-7 cells, indicating that PLC-gamma1 functions as a positive regulator in taxol-induced MCP-1 expression. Paclitaxel 211-216 C-C motif chemokine ligand 2 Homo sapiens 202-207 19885629-9 2009 On the other hand, taxol-induced up-regulation of MCP-1 was reduced in cells treated with U73122, an inhibitor of phospholipase C (PLC), and ectopic expression of PLC-gamma1 increased the expression of MCP-1 in taxol-treated MCF-7 cells, indicating that PLC-gamma1 functions as a positive regulator in taxol-induced MCP-1 expression. Paclitaxel 211-216 C-C motif chemokine ligand 2 Homo sapiens 202-207 19944317-0 2009 Effect of edaravone on plasma monocyte chemoattractant protein-1 levels in patients with acute myocardial infarction. Edaravone 10-19 C-C motif chemokine ligand 2 Homo sapiens 30-64 19944317-3 2009 METHODS: Plasma MCP-1 levels were measured in 45 consecutive patients with AMI (edaravone group, n=25; control group, n=20). Edaravone 80-89 C-C motif chemokine ligand 2 Homo sapiens 16-21 19944317-9 2009 Compared with the placebo group, the edaravone group had statistically lower maximum creatine kinase-MB levels (218+-31 IU/l versus 145+-21 IU/l, p<0.05) and plasma MCP-1 levels on day 3 after reperfusion (873+-118 pg/ml versus 516+-66 pg/ml, p<0.05). Edaravone 37-46 C-C motif chemokine ligand 2 Homo sapiens 168-173 19944317-12 2009 CONCLUSION: Edaravone suppressed plasma MCP-1, improved left ventricular ejection fraction, and reduced rehospitalization due to heart failure. Edaravone 12-21 C-C motif chemokine ligand 2 Homo sapiens 40-45 19944317-13 2009 Suppression of plasma MCP-1 level by edaravone might induce better prognosis for AMI patients. Edaravone 37-46 C-C motif chemokine ligand 2 Homo sapiens 22-27 19759193-6 2009 Caffeic acid phenethyl ester and parthenolide inhibited NF-kappaB activation, as seen by gel shift assays and immunoblotting for p65 in nuclear fractions, as well as decreased production of IL-6 and MCP-1. caffeic acid phenethyl ester 0-28 C-C motif chemokine ligand 2 Homo sapiens 199-204 20019839-3 2009 This study demonstrates that upon serum starvation, CCL2 functions as a negative regulator of AMP-activated protein kinase (AMPK) by decreasing phosphorylation at its major regulatory site (Thr(172)) in PC3, DU145, and C4-2B prostate cancer cells. Threonine 190-193 C-C motif chemokine ligand 2 Homo sapiens 52-56 20019839-4 2009 The CCL2-mediated AMPK regulation decreased raptor phosphorylation (Ser(792)) resulting in hyperactivation of mTORC1. Serine 68-71 C-C motif chemokine ligand 2 Homo sapiens 4-8 20019839-8 2009 Furthermore, bisindolylmaleimide-V, a specific inhibitor of p70(S6K), stunted survivin expression and induced cell death in CCL2-treated PC3. bisindolylmaleimide V 13-34 C-C motif chemokine ligand 2 Homo sapiens 124-128 19966527-8 2009 In addition, the levels of MCP-1 and SDF-1alpha were significantly elevated in the untreated patients, but were significantly lower in the patients treated with LOR. lornoxicam 161-164 C-C motif chemokine ligand 2 Homo sapiens 27-32 19741020-8 2009 High glucose (25 mM) increased TNF-alpha, IL-6, and monocyte chemoattractant protein-1 in mesangial cell conditioned medium. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 52-86 19846883-4 2009 Maturation of DCs with zymosan reduced CysLT1 mRNA levels and protein expression in a time-dependent fashion and was associated with a diminution of functional responsiveness to leukotriene D(4) as assessed by intracellular calcium mobilization, CCL2 and CCL3 production, and chemotaxis. Zymosan 23-30 C-C motif chemokine ligand 2 Homo sapiens 246-250 19741199-5 2009 Treatment of macrovascular human umbilical vein endothelial cells (HUVECs) and microvascular endothelial cells (MVECs) with the cholinergic agonists nicotine and GTS-21 significantly reduced IL-6-mediated monocyte chemoattractant protein-1 (MCP-1) production and ICAM-1 expression which are regulated through the JAK2/STAT3 pathway. Nicotine 149-157 C-C motif chemokine ligand 2 Homo sapiens 205-239 19741199-5 2009 Treatment of macrovascular human umbilical vein endothelial cells (HUVECs) and microvascular endothelial cells (MVECs) with the cholinergic agonists nicotine and GTS-21 significantly reduced IL-6-mediated monocyte chemoattractant protein-1 (MCP-1) production and ICAM-1 expression which are regulated through the JAK2/STAT3 pathway. Nicotine 149-157 C-C motif chemokine ligand 2 Homo sapiens 241-246 19759193-6 2009 Caffeic acid phenethyl ester and parthenolide inhibited NF-kappaB activation, as seen by gel shift assays and immunoblotting for p65 in nuclear fractions, as well as decreased production of IL-6 and MCP-1. parthenolide 33-45 C-C motif chemokine ligand 2 Homo sapiens 199-204 19759193-7 2009 Supplementation of MC3T3-E1 with methylseleninic acid (MSA) (0.5 microM to 4 microM) reduced the activation of NF-kappaB leading to a decrease in IL-6, MCP-1, COX-2 and iNOS in response to MDA-MB-231 conditioned medium. methylselenic acid 33-53 C-C motif chemokine ligand 2 Homo sapiens 152-157 19759193-7 2009 Supplementation of MC3T3-E1 with methylseleninic acid (MSA) (0.5 microM to 4 microM) reduced the activation of NF-kappaB leading to a decrease in IL-6, MCP-1, COX-2 and iNOS in response to MDA-MB-231 conditioned medium. methylselenic acid 55-58 C-C motif chemokine ligand 2 Homo sapiens 152-157 19446037-6 2009 Using proteosome inhibitor MG132 and I kappaB overexpression we demonstrated that an NF-kappaB-dependent mechanism was involved in both the activation of IL-8 and the repression of MCP-1 mRNA expression in response to hypoxia. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 27-32 C-C motif chemokine ligand 2 Homo sapiens 181-186 19446037-7 2009 The histone deacetylase inhibitor Trihostatin A abolished the inhibitory actions of hypoxia on IL-1 beta-induced MCP-1 gene expression. trihostatin a 34-47 C-C motif chemokine ligand 2 Homo sapiens 113-118 19712757-4 2009 Pidotimod also stimulated DCs to release high amounts of pro-inflammatory molecules such as MCP-1 and TNF-alpha cytokines and to drive T cell proliferation and differentiation towards a Th1 phenotype. pidotimod 0-9 C-C motif chemokine ligand 2 Homo sapiens 92-97 19680683-7 2009 Inhibition of voltage-gated K+ channels with 4-aminopyridine or margatoxin partially inhibited MCP-1- and LPC-stimulated migration of monocytes. 4-Aminopyridine 45-60 C-C motif chemokine ligand 2 Homo sapiens 95-100 19675564-2 2009 Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion. Phosphatidylserines 65-83 C-C motif chemokine ligand 2 Homo sapiens 220-224 19675564-2 2009 Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion. Phosphatidylserines 85-87 C-C motif chemokine ligand 2 Homo sapiens 220-224 19675564-2 2009 Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6, Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion. Phosphatidylcholines 93-112 C-C motif chemokine ligand 2 Homo sapiens 220-224 19759245-10 2009 Moreover, the secretion of inflammatory molecules (interleukin-6 and monocyte chemoattractant protein-1) induced by macrophage-secreted factors was partially abolished in 100 micromol/L 1,2-DT-treated preadipocytes (-28 and -25%, respectively). 1,2-dt 186-192 C-C motif chemokine ligand 2 Homo sapiens 69-103 19680683-8 2009 Blockade of Ca2+-activated K+ channels with TRAM-34 also partially reduced migration of MCP-1- and LPC-stimulated monocytes. TRAM 34 44-51 C-C motif chemokine ligand 2 Homo sapiens 88-93 19825152-8 2009 For both rs12255372 and rs7903146, homozygote T-allele carriers had significantly higher (P < 0.05) post-fenofibrate concentrations of MCP-1 in the recessive model. Fenofibrate 108-119 C-C motif chemokine ligand 2 Homo sapiens 138-143 19561397-3 2009 The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-kapaB inhibitor completely suppressed the IL-1beta-induced MCP1 expression through blocking NF-gammaB translocation to the nucleus. Phosphatidylcholines 22-41 C-C motif chemokine ligand 2 Homo sapiens 171-175 19561397-3 2009 The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-kapaB inhibitor completely suppressed the IL-1beta-induced MCP1 expression through blocking NF-gammaB translocation to the nucleus. Phosphatidylcholines 43-45 C-C motif chemokine ligand 2 Homo sapiens 171-175 19561397-3 2009 The pretreatment of a phosphatidylcholine (PC)-specific PLC (PC-PLC) inhibitor (D609), PKC inhibitors, or an NF-kapaB inhibitor completely suppressed the IL-1beta-induced MCP1 expression through blocking NF-gammaB translocation to the nucleus. tricyclodecane-9-yl-xanthogenate 80-84 C-C motif chemokine ligand 2 Homo sapiens 171-175 20160907-7 2009 Finally, we compared the collisional activation data for the MCP-1 dimer with an MCP-1 dimer non-covalently bound to a single molecule of the semi-synthetic glycosaminoglycan (GAG) analog Arixtra ; the latter a therapeutic anti-thrombin III-activating pentasaccharide. Glycosaminoglycans 157-174 C-C motif chemokine ligand 2 Homo sapiens 81-86 20160907-7 2009 Finally, we compared the collisional activation data for the MCP-1 dimer with an MCP-1 dimer non-covalently bound to a single molecule of the semi-synthetic glycosaminoglycan (GAG) analog Arixtra ; the latter a therapeutic anti-thrombin III-activating pentasaccharide. Glycosaminoglycans 176-179 C-C motif chemokine ligand 2 Homo sapiens 81-86 20160907-7 2009 Finally, we compared the collisional activation data for the MCP-1 dimer with an MCP-1 dimer non-covalently bound to a single molecule of the semi-synthetic glycosaminoglycan (GAG) analog Arixtra ; the latter a therapeutic anti-thrombin III-activating pentasaccharide. Fondaparinux 188-195 C-C motif chemokine ligand 2 Homo sapiens 81-86 20160907-8 2009 We observed that while dimeric MCP-1 dissociated at relatively low trap CEs, the Arixtra-bound dimer required much higher energies, which also induced covalent bond cleavage in the bound Arixtra molecule. Cerium 72-75 C-C motif chemokine ligand 2 Homo sapiens 31-36 20160907-8 2009 We observed that while dimeric MCP-1 dissociated at relatively low trap CEs, the Arixtra-bound dimer required much higher energies, which also induced covalent bond cleavage in the bound Arixtra molecule. Fondaparinux 81-88 C-C motif chemokine ligand 2 Homo sapiens 31-36 20160907-8 2009 We observed that while dimeric MCP-1 dissociated at relatively low trap CEs, the Arixtra-bound dimer required much higher energies, which also induced covalent bond cleavage in the bound Arixtra molecule. Fondaparinux 187-194 C-C motif chemokine ligand 2 Homo sapiens 31-36 20160907-10 2009 That both dimers shifted to longer arrival times with increasing activation energy, while the dissociated MCP-1 monomers remained compact, suggests that the longer arrival times of the Arixtra-free and Arixtra-bound dimers may represent a partial breach of non-covalent interactions between the associated MCP-1 monomers, rather than extensive unfolding of individual subunits. Fondaparinux 185-192 C-C motif chemokine ligand 2 Homo sapiens 106-111 20160907-10 2009 That both dimers shifted to longer arrival times with increasing activation energy, while the dissociated MCP-1 monomers remained compact, suggests that the longer arrival times of the Arixtra-free and Arixtra-bound dimers may represent a partial breach of non-covalent interactions between the associated MCP-1 monomers, rather than extensive unfolding of individual subunits. Fondaparinux 202-209 C-C motif chemokine ligand 2 Homo sapiens 106-111 20160907-10 2009 That both dimers shifted to longer arrival times with increasing activation energy, while the dissociated MCP-1 monomers remained compact, suggests that the longer arrival times of the Arixtra-free and Arixtra-bound dimers may represent a partial breach of non-covalent interactions between the associated MCP-1 monomers, rather than extensive unfolding of individual subunits. Fondaparinux 202-209 C-C motif chemokine ligand 2 Homo sapiens 306-311 20160907-11 2009 The fact that Arixtra preferentially binds MCP-1 dimers and prevents dimer dissociation at comparable activation energies to the Arixtra-free dimer, may suggest that the drug interacts across the two monomers, thereby inhibiting their dissociation. Fondaparinux 14-21 C-C motif chemokine ligand 2 Homo sapiens 43-48 19607809-3 2009 Both OA-NO(2) and LNO(2) prevented TNFalpha-stimulated release of the cytokines, IL-6, IL-8, IL-12/p40, IFNgamma, MCP-1, and IP-10, and inhibited NF-kappaB activation. L-Leucyl-Hydroxylamine 18-21 C-C motif chemokine ligand 2 Homo sapiens 114-119 19587377-5 2009 Transcriptome analysis on normal MSCs treated with the glucocerebrosidase inhibitor conduritol B epoxide showed an up-regulation of an array of inflammatory mediators, including CCL2, and other differentially regulated pathways. conduritol epoxide 84-104 C-C motif chemokine ligand 2 Homo sapiens 178-182 19446813-4 2009 Digitoxin, employing therapeutical concentrations used in patients (3-30nM), potently inhibited the IL-1beta-induced expression of MCP-1 and VCAM-1 in EC and the capacity of corresponding cell culture supernatants on monocyte migration as well as monocyte adhesion to endothelial monolayers, respectively. Digitoxin 0-9 C-C motif chemokine ligand 2 Homo sapiens 131-136 19852204-0 2009 Regulation of monocyte chemoattractant protein 1 by cysteinyl leukotriene D4 in human lung epithelial A549 cells. cysteinyl leukotriene d4 52-76 C-C motif chemokine ligand 2 Homo sapiens 14-48 19667211-9 2009 RESULTS: CCL1, CCL2, CCL7, CXCL10, CXCL11, and CCR1 gene expression was strongly upregulated in interferon beta-treated, NAB-negative MS patients. nab 121-124 C-C motif chemokine ligand 2 Homo sapiens 15-19 19759376-5 2009 Increasing levels of sESAM were associated with all major cardiovascular risk factors as well as with inflammatory markers such as monocyte chemoattractant protein-1, but only weakly correlated with sICAM-1 and sVCAM-1. sesam 21-26 C-C motif chemokine ligand 2 Homo sapiens 131-165 19446813-6 2009 Inhibition of NF-kappaB signaling but not p44/42-MAPK mimicked the observed inhibitory effects of digitoxin on MCP-1 expression and monocyte migration. Digitoxin 98-107 C-C motif chemokine ligand 2 Homo sapiens 111-116 19673614-10 2009 Also, the patients who received rosiglitazone had reduced inflammatory responses to infection, compared with the patients who received a placebo (ie, interleukin-6 levels at 24 h [p < .005] and at 48 h [p = .013] and monocyte chemoattractant protein-1 level at 48 h [p = .05]). Rosiglitazone 32-45 C-C motif chemokine ligand 2 Homo sapiens 220-254 19529000-9 2009 These results indicated that GL suppresses the PMN-dependent increase of R5 HIV replication in MDMs through inhibiting CCL2/IL-10 production by PMNs stimulated with R5 HIV. Glycyrrhizic Acid 29-31 C-C motif chemokine ligand 2 Homo sapiens 119-123 19625220-0 2009 Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1. Folic Acid 0-6 C-C motif chemokine ligand 2 Homo sapiens 97-131 19625220-0 2009 Folate/homocysteine phenotypes and MTHFR 677C>T genotypes are associated with serum levels of monocyte chemoattractant protein-1. Homocysteine 7-19 C-C motif chemokine ligand 2 Homo sapiens 97-131 19674806-7 2009 Serum MMP-9 levels were decreased in the metformin (-13.5+/-34.8%, p=0.02) and rosiglitazone (-27.2+/-51.0%, p=0.023) groups compared with baseline values, whereas no significant change was seen in serum MCP-1 levels. Metformin 41-50 C-C motif chemokine ligand 2 Homo sapiens 204-209 19674806-7 2009 Serum MMP-9 levels were decreased in the metformin (-13.5+/-34.8%, p=0.02) and rosiglitazone (-27.2+/-51.0%, p=0.023) groups compared with baseline values, whereas no significant change was seen in serum MCP-1 levels. Rosiglitazone 79-92 C-C motif chemokine ligand 2 Homo sapiens 204-209 19563447-10 2009 LPS-induced release of monocytic MCP-1 and TNF was significantly and positively correlated with serum triglyceride levels in 30 patients with T2D. Triglycerides 102-114 C-C motif chemokine ligand 2 Homo sapiens 33-38 19535686-7 2009 In contrast, S1P stimulated secretion of the chemokine, monocyte chemoattractant protein 1 (MCP-1/CCL2), from these macrophage-depleted and purified CB-MCs. cb-mcs 149-155 C-C motif chemokine ligand 2 Homo sapiens 56-90 19535686-7 2009 In contrast, S1P stimulated secretion of the chemokine, monocyte chemoattractant protein 1 (MCP-1/CCL2), from these macrophage-depleted and purified CB-MCs. cb-mcs 149-155 C-C motif chemokine ligand 2 Homo sapiens 92-97 19535686-7 2009 In contrast, S1P stimulated secretion of the chemokine, monocyte chemoattractant protein 1 (MCP-1/CCL2), from these macrophage-depleted and purified CB-MCs. cb-mcs 149-155 C-C motif chemokine ligand 2 Homo sapiens 98-102 19443712-1 2009 PURPOSE: To investigate the role of HtrA2/Omi, a nuclear-encoded mitochondrial serine protease with a proapoptosis function, under H(2)O(2)-induced oxidative stress in human RPE, in the Ccl2(-)(/)(-)Cx3cr1(-)(/)(-) double-knockout (DKO) mouse retina, and the HtrA2/Omi-deficient mice. Hydrogen Peroxide 131-139 C-C motif chemokine ligand 2 Homo sapiens 186-190 25949368-0 2009 Enoxaparin decreases serum MCP-1 concentration during haemodialysis-preliminary report. Enoxaparin 0-10 C-C motif chemokine ligand 2 Homo sapiens 27-32 19647751-3 2009 KEY FINDINGS: We showed that gAd induces the expression of a number of genes using PCR arrays, including MCP-1, VCAM-1, E-selectin, IL-6, and IL-8, all of which have been previously shown to be associated with adiponectin, as well as SOD2, PAI-1, and CSF2, which is a new finding. ganoderic acid D 29-32 C-C motif chemokine ligand 2 Homo sapiens 105-110 19592499-8 2009 Knockdown of Par3 significantly reduced MCP1-induced chemotaxis of THP-1 monocytes, as did knockdown of SPTLC1, and this Par3 effect depended upon SPT activity and was blunted by ceramide treatment. Ceramides 179-187 C-C motif chemokine ligand 2 Homo sapiens 40-44 18926686-6 2009 Retinoic acid also repressed LPS-induced transcription of NF-kappaB target genes such as IL-6, MCP-1 and COX-2. Tretinoin 0-13 C-C motif chemokine ligand 2 Homo sapiens 95-100 19555664-4 2009 Upregulation of MCP-1 by TrxR1 was associated with increasing generation of intracellular ROS generation, enhanced nuclear translocation and DNA-binding activity of NF-kappaB. Reactive Oxygen Species 90-93 C-C motif chemokine ligand 2 Homo sapiens 16-21 19597037-8 2009 In vitro, SAR407899 demonstrated concentration-dependent inhibition of Rho-kinase-mediated phosphorylation of myosin phosphatase, thrombin-induced stress fiber formation, platelet-derived growth factor-induced proliferation, and monocyte chemotactic protein-1-stimulated chemotaxis. SAR407899 10-19 C-C motif chemokine ligand 2 Homo sapiens 229-259 19525846-0 2009 Effects of pitavastatin on monocyte chemoattractant protein-1 in hyperlipidemic patients. pitavastatin 11-23 C-C motif chemokine ligand 2 Homo sapiens 27-61 19525846-9 2009 When pitavastatin-treated patients were divided into two groups according to the adiponectin response to pitavastatin treatment, significant decreases of the plasma MCP-1, PDMP and sCD40L levels were observed after pitavastatin treatment in the responder group. pitavastatin 5-17 C-C motif chemokine ligand 2 Homo sapiens 165-170 19451399-4 2009 In fact, the bacterial tripeptide fMLP, but not the cytokines IL-1beta or IFN-gamma, significantly and dose-dependently synergized with CCL2 in monocyte chemotaxis. tripeptide K-26 23-33 C-C motif chemokine ligand 2 Homo sapiens 136-140 19592054-7 2009 Finally, L-arginine increased insulin sensitivity index (P < .05) and adiponectin (P < .01) and decreased interleukin-6 and monocyte chemoattractant protein-1 levels. Arginine 9-19 C-C motif chemokine ligand 2 Homo sapiens 130-164 19570035-0 2009 Prostaglandin EP2 and EP4 receptors modulate expression of the chemokine CCL2 (MCP-1) in response to LPS-induced renal glomerular inflammation. Prostaglandins 0-13 C-C motif chemokine ligand 2 Homo sapiens 73-77 19570035-0 2009 Prostaglandin EP2 and EP4 receptors modulate expression of the chemokine CCL2 (MCP-1) in response to LPS-induced renal glomerular inflammation. Prostaglandins 0-13 C-C motif chemokine ligand 2 Homo sapiens 79-84 19570035-1 2009 The pro-inflammatory chemokine CCL2 [chemokine (Cys-Cys motif) ligand 2; also known as MCP-1 (monocyte chemotactic protein-1)] is up-regulated in the glomerular compartment during the early phase of LPS (lipopolysaccharide)-induced nephritis. cysteinylcysteine 48-55 C-C motif chemokine ligand 2 Homo sapiens 31-35 19570035-1 2009 The pro-inflammatory chemokine CCL2 [chemokine (Cys-Cys motif) ligand 2; also known as MCP-1 (monocyte chemotactic protein-1)] is up-regulated in the glomerular compartment during the early phase of LPS (lipopolysaccharide)-induced nephritis. cysteinylcysteine 48-55 C-C motif chemokine ligand 2 Homo sapiens 87-92 19570035-1 2009 The pro-inflammatory chemokine CCL2 [chemokine (Cys-Cys motif) ligand 2; also known as MCP-1 (monocyte chemotactic protein-1)] is up-regulated in the glomerular compartment during the early phase of LPS (lipopolysaccharide)-induced nephritis. cysteinylcysteine 48-55 C-C motif chemokine ligand 2 Homo sapiens 94-124 19661323-5 2009 CCL2-induced phosphorylation of Akt was inhibited by pertussis toxin and the adenylyl cyclase inhibitor SQ22536. 9-(tetrahydro-2-furyl)-adenine 104-111 C-C motif chemokine ligand 2 Homo sapiens 0-4 19634869-6 2009 Moreover, other constituents, namely, iso-alpha-acids, in combination with the beta-acid hulupone, showed a moderate but selective inhibitory activity only on MCP-1 release. iso-alpha-acids 38-53 C-C motif chemokine ligand 2 Homo sapiens 159-164 19634869-6 2009 Moreover, other constituents, namely, iso-alpha-acids, in combination with the beta-acid hulupone, showed a moderate but selective inhibitory activity only on MCP-1 release. beta-acid hulupone 79-97 C-C motif chemokine ligand 2 Homo sapiens 159-164 19525388-10 2009 Ox-AT generated in the airway interacts directly with epithelial cells to release chemokines IL-8 and MCP-1, which in turn attracts macrophages and neutrophils into the airways. ox-at 0-5 C-C motif chemokine ligand 2 Homo sapiens 102-107 19443025-11 2009 MCP-1 secretion from monocytes on PEG-only hydrogels was Hck independent in contrast to Hck-dependent MCP-1 secretion in U937 on TCPS. Polyethylene Glycols 34-37 C-C motif chemokine ligand 2 Homo sapiens 0-5 19556365-8 2009 Knockdown of BRG1 by small interfering RNA blocked an ATP depletion-induced increase in TNF-alpha and MCP-1 transcription in a human proximal tubule cell line; this effect was associated with decreased recruitment of BRG1 and Pol II to these genes. Adenosine Triphosphate 54-57 C-C motif chemokine ligand 2 Homo sapiens 102-107 19342461-2 2009 We recently found that C-C chemokines such as CCL2, CCL7, and CCL9 are produced and stimulate integrin-mediated ECM assembly in the postovulatory cumulus to protect eggs and that prostaglandin E(2)-EP2 signaling in the cumulus cells facilitates fertilization by suppressing this chemokine signaling, which otherwise results in fertilization failure by preventing sperm penetration through the cumulus ECM. Dinoprostone 179-197 C-C motif chemokine ligand 2 Homo sapiens 46-50 19842489-4 2009 Complexes of C(NH3)2, C(PH3)2, C[P(CH3)3]2, CF2, CCl2, and imidazol-2-ylidene with such proton donors as H2O, HCF3, HCN and HCCH have been analyzed by means of high-level quantum chemical methods. Carbon 0-1 C-C motif chemokine ligand 2 Homo sapiens 49-53 19842489-4 2009 Complexes of C(NH3)2, C(PH3)2, C[P(CH3)3]2, CF2, CCl2, and imidazol-2-ylidene with such proton donors as H2O, HCF3, HCN and HCCH have been analyzed by means of high-level quantum chemical methods. Water 105-108 C-C motif chemokine ligand 2 Homo sapiens 49-53 19406381-0 2009 Analysis of gene expression profiles in human periodontal ligament cells under hypoxia: the protective effect of CC chemokine ligand 2 to oxygen shortage. Oxygen 138-144 C-C motif chemokine ligand 2 Homo sapiens 113-134 19406381-8 2009 However, the exogenous CCL2 prevented PDL cell death under oxygen shortage with the increment of cellular inhibitor of apoptosis (cIAP) mRNA expression. Oxygen 59-65 C-C motif chemokine ligand 2 Homo sapiens 23-27 19409809-4 2009 Urinary MCP-1/creatinine ratios were found to be significantly higher in patients with macroalbuminuria (3.3- and 2.1-fold higher (p<0.01) than normoalbuminuric and microalbuminuric patients, respectively). Creatinine 14-24 C-C motif chemokine ligand 2 Homo sapiens 8-13 19415233-7 2009 RESULTS: Treatment of LPS-stimulated human islets with the synthetic LXR agonist GW3965 (1 micromol/l) for 24 h reduced mRNA and protein levels of selected pro-inflammatory cytokines (IL-8, monocyte chemotactic protein-1 and tissue factor). GW 3965 81-87 C-C motif chemokine ligand 2 Homo sapiens 190-238 19594939-12 2009 The expression levels of IL-8, ICAM-1, IP-10, MCP-1, TNF-alpha and MMP-1 were significantly reduced after PC pre-treatment for at least two hours. Phosphatidylcholines 106-108 C-C motif chemokine ligand 2 Homo sapiens 46-51 19152916-3 2009 We investigated the mechanisms underlying the modulation of MCP-1 expression by long-term "folate stress". Folic Acid 91-97 C-C motif chemokine ligand 2 Homo sapiens 60-65 19166999-7 2009 We found the increase in MCP-1 and CCR2 levels by visfatin were negated by LY294002 and BAY11-7085, but not with U0126, suggesting the crucial role of PI3Kinase and NF-kappaB pathways in visfatin induced MCP-1 and its autocrine regulation via the CCR2 receptor. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 75-83 C-C motif chemokine ligand 2 Homo sapiens 25-30 19132727-2 2009 Titanium particles have previously been shown to induce IL-8 and MCP-1 secretion in osteoblasts. Titanium 0-8 C-C motif chemokine ligand 2 Homo sapiens 65-70 18789665-0 2009 Red wine anthocyanins are rapidly absorbed in humans and affect monocyte chemoattractant protein 1 levels and antioxidant capacity of plasma. Anthocyanins 9-21 C-C motif chemokine ligand 2 Homo sapiens 64-98 18789665-10 2009 Total urinary excretion of red wine anthocyanins was 0.05+/-0.01% of the administered dose within 24 h. About 94% of the excreted anthocyanins was found in urine within 6 h. In spite of the low concentration of anthocyanins found in plasma, an increase in the antioxidant capacity and a decrease in MCP-1 circulating levels in plasma were observed. Anthocyanins 36-48 C-C motif chemokine ligand 2 Homo sapiens 299-304 19132727-6 2009 We demonstrate that cobalt ions rapidly induce the protein secretion of IL-8 and MCP-1 in primary human osteoblasts. Cobalt 20-26 C-C motif chemokine ligand 2 Homo sapiens 81-86 19132727-10 2009 In aggregate these data demonstrate that cobalt ions can activate transcription of the chemokine genes IL-8 and MCP-1 in primary human osteoblasts. Cobalt 41-47 C-C motif chemokine ligand 2 Homo sapiens 112-117 18976766-0 2009 Raloxifene reduces circulating levels of interleukin-7 and monocyte chemoattractant protein-1 in postmenopausal women. Raloxifene Hydrochloride 0-10 C-C motif chemokine ligand 2 Homo sapiens 59-93 19781192-0 2009 [NADPH oxidase-derived reactive oxygen species involved in angiotensin II-induced monocyte chemoattractant protein-1 expression in mesangial cells]. Reactive Oxygen Species 23-46 C-C motif chemokine ligand 2 Homo sapiens 82-116 19781192-1 2009 OBJECTIVE: To investigate the origin of oxidative stress induced by angiotensin II (AngII) in human mesangial cells and the role of reactive oxygen species (ROS) in AngII-induced monocyte chemoattractant protein-1 (MCP-1) expression. Reactive Oxygen Species 157-160 C-C motif chemokine ligand 2 Homo sapiens 179-213 19781192-18 2009 CONCLUSIONS: NADPH oxidase-derived ROS is involved in AngII-induced MCP-1 expression. Reactive Oxygen Species 35-38 C-C motif chemokine ligand 2 Homo sapiens 68-73 19332545-3 2009 Incubation of monocytes with ABA evokes an intracellular Ca2+ rise through the second messenger cyclic ADP-ribose, leading to NF-kappaB activation and consequent increase of cyclooxygenase-2 expression and prostaglandin E2 production and enhanced release of MCP-1 (monocyte chemoattractant protein-1) and of metalloprotease-9, all events reportedly involved in atherogenesis. Abscisic Acid 29-32 C-C motif chemokine ligand 2 Homo sapiens 258-263 19332545-3 2009 Incubation of monocytes with ABA evokes an intracellular Ca2+ rise through the second messenger cyclic ADP-ribose, leading to NF-kappaB activation and consequent increase of cyclooxygenase-2 expression and prostaglandin E2 production and enhanced release of MCP-1 (monocyte chemoattractant protein-1) and of metalloprotease-9, all events reportedly involved in atherogenesis. Abscisic Acid 29-32 C-C motif chemokine ligand 2 Homo sapiens 265-299 19332545-3 2009 Incubation of monocytes with ABA evokes an intracellular Ca2+ rise through the second messenger cyclic ADP-ribose, leading to NF-kappaB activation and consequent increase of cyclooxygenase-2 expression and prostaglandin E2 production and enhanced release of MCP-1 (monocyte chemoattractant protein-1) and of metalloprotease-9, all events reportedly involved in atherogenesis. Cyclic ADP-Ribose 96-113 C-C motif chemokine ligand 2 Homo sapiens 258-263 19332545-3 2009 Incubation of monocytes with ABA evokes an intracellular Ca2+ rise through the second messenger cyclic ADP-ribose, leading to NF-kappaB activation and consequent increase of cyclooxygenase-2 expression and prostaglandin E2 production and enhanced release of MCP-1 (monocyte chemoattractant protein-1) and of metalloprotease-9, all events reportedly involved in atherogenesis. Cyclic ADP-Ribose 96-113 C-C motif chemokine ligand 2 Homo sapiens 265-299 19332545-4 2009 Moreover, monocytes release ABA when exposed to thrombin-activated platelets, a condition occurring at the injured vascular endothelium; monocyte-derived ABA behaves as an autocrine and paracrine pro-inflammatory hormone-stimulating monocyte migration and MCP-1 release, as well as vascular smooth muscle cells migration and proliferation. Abscisic Acid 154-157 C-C motif chemokine ligand 2 Homo sapiens 256-261 19375763-9 2009 Fasting MCP-1 levels correlated with activated nuclear factor kappaB during hyperglycemia (P < .05) and androstenedione (P < .004). Androstenedione 107-122 C-C motif chemokine ligand 2 Homo sapiens 8-13 19524871-7 2009 We used calcium ionophore as a positive control for stimulating transcription and translation of CCL2/MCP-1. Calcium 8-15 C-C motif chemokine ligand 2 Homo sapiens 97-101 19524871-7 2009 We used calcium ionophore as a positive control for stimulating transcription and translation of CCL2/MCP-1. Calcium 8-15 C-C motif chemokine ligand 2 Homo sapiens 102-107 19953890-11 2009 The concentrations of MCP-1 and VCAM-1 in cellular supernatant of the H2O2 treatment group were significantly higher than those of the control group [(69.2 +/- 3.5) ng/ml vs (62.5 +/- 3.6) ng/ml, P < 0.05; (114.0 +/- 7.5) ng/ml vs (97.2 +/- 5.0) ng/ml, P < 0.01]. Hydrogen Peroxide 70-74 C-C motif chemokine ligand 2 Homo sapiens 22-27 18976766-5 2009 RESULTS: Serum IL-7 concentrations in women who received raloxifene were decreased significantly (p=0.014), and serum monocyte chemoattractant protein (MCP)-1 concentrations in women who received raloxifene were decreased significantly (p=0.0003) at 12 months. Raloxifene Hydrochloride 196-206 C-C motif chemokine ligand 2 Homo sapiens 118-158 18976766-7 2009 There were significant differences (p=0.032 and p=0.0024, respectively) in percentage changes in IL-7 and MCP-1 in the control group and in the raloxifene group. Raloxifene Hydrochloride 144-154 C-C motif chemokine ligand 2 Homo sapiens 106-111 18976766-9 2009 CONCLUSION: Circulating levels of IL-7 and MCP-1 decrease in postmenopausal women who received raloxifene. Raloxifene Hydrochloride 95-105 C-C motif chemokine ligand 2 Homo sapiens 43-48 19439823-8 2009 The level of MCP-1 cultured in supernatant of macrophages was higher than in PRMI-1640 with the same biomaterials. prmi-1640 77-86 C-C motif chemokine ligand 2 Homo sapiens 13-18 19439823-10 2009 MCP-1 was also significantly expressed in beta-tricalcium phosphate (beta-TCP) and calcium phosphate cement samples (CPC) (p < 0.01). beta-tricalcium phosphate 42-67 C-C motif chemokine ligand 2 Homo sapiens 0-5 19439823-10 2009 MCP-1 was also significantly expressed in beta-tricalcium phosphate (beta-TCP) and calcium phosphate cement samples (CPC) (p < 0.01). beta-tricalcium phosphate 69-77 C-C motif chemokine ligand 2 Homo sapiens 0-5 19371341-12 2009 Blocking the inhibitor of kappaB kinase-2 with 2-[(aminocarbonyl)amino]-5-[4-fluorophenyl]-3-thiophenecarboxamide (TPCA-1) decreased ET-1-stimulated MCP-1 production. 2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide 47-113 C-C motif chemokine ligand 2 Homo sapiens 149-154 19439823-10 2009 MCP-1 was also significantly expressed in beta-tricalcium phosphate (beta-TCP) and calcium phosphate cement samples (CPC) (p < 0.01). calcium phosphate 50-67 C-C motif chemokine ligand 2 Homo sapiens 0-5 19234337-12 2009 Studies using human ECs demonstrated that TNF-alpha-induced CCL2 production was also inhibited by the NAD(P)H oxidase inhibitor DPI, the antioxidant N-acetyl-L-cysteine, or the superoxide scavenger Tiron, further indicating that inhibition occurs through the NAD(P)H/ROS pathway. 3-aminodiphenyleneiodium 128-131 C-C motif chemokine ligand 2 Homo sapiens 60-64 19490202-4 2009 DISCUSSION: Thiazolidinediones attenuate circulating levels of pro-inflammatory mediators in patients with type 2 diabetes, including C-reactive protein, interleukin-6, CD40L, monocyte chemoattractant protein-1 and metalloproteinase-9. Thiazolidinediones 12-30 C-C motif chemokine ligand 2 Homo sapiens 176-234 19234337-12 2009 Studies using human ECs demonstrated that TNF-alpha-induced CCL2 production was also inhibited by the NAD(P)H oxidase inhibitor DPI, the antioxidant N-acetyl-L-cysteine, or the superoxide scavenger Tiron, further indicating that inhibition occurs through the NAD(P)H/ROS pathway. Acetylcysteine 149-168 C-C motif chemokine ligand 2 Homo sapiens 60-64 19234337-12 2009 Studies using human ECs demonstrated that TNF-alpha-induced CCL2 production was also inhibited by the NAD(P)H oxidase inhibitor DPI, the antioxidant N-acetyl-L-cysteine, or the superoxide scavenger Tiron, further indicating that inhibition occurs through the NAD(P)H/ROS pathway. Superoxides 177-187 C-C motif chemokine ligand 2 Homo sapiens 60-64 19234337-12 2009 Studies using human ECs demonstrated that TNF-alpha-induced CCL2 production was also inhibited by the NAD(P)H oxidase inhibitor DPI, the antioxidant N-acetyl-L-cysteine, or the superoxide scavenger Tiron, further indicating that inhibition occurs through the NAD(P)H/ROS pathway. 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt 198-203 C-C motif chemokine ligand 2 Homo sapiens 60-64 19234337-12 2009 Studies using human ECs demonstrated that TNF-alpha-induced CCL2 production was also inhibited by the NAD(P)H oxidase inhibitor DPI, the antioxidant N-acetyl-L-cysteine, or the superoxide scavenger Tiron, further indicating that inhibition occurs through the NAD(P)H/ROS pathway. nad(p)h 102-109 C-C motif chemokine ligand 2 Homo sapiens 60-64 19234337-12 2009 Studies using human ECs demonstrated that TNF-alpha-induced CCL2 production was also inhibited by the NAD(P)H oxidase inhibitor DPI, the antioxidant N-acetyl-L-cysteine, or the superoxide scavenger Tiron, further indicating that inhibition occurs through the NAD(P)H/ROS pathway. ros 267-270 C-C motif chemokine ligand 2 Homo sapiens 60-64 19382275-11 2009 Secretion of MCP-1 was also reduced in the presence of nicotinamide, from infected and uninfected islets. Niacinamide 55-67 C-C motif chemokine ligand 2 Homo sapiens 13-18 19454720-6 2009 Induction of CCL2, CCL7, CXCL3, and CXCL8 by anti-IgE was significantly inhibited by dexamethasone but was enhanced by FK506. Dexamethasone 85-98 C-C motif chemokine ligand 2 Homo sapiens 13-17 19454720-6 2009 Induction of CCL2, CCL7, CXCL3, and CXCL8 by anti-IgE was significantly inhibited by dexamethasone but was enhanced by FK506. Tacrolimus 119-124 C-C motif chemokine ligand 2 Homo sapiens 13-17 19398228-7 2009 Silybin (25-50 microM), inhibited the IL-1-induced synthesis of MCP-1 (P < 0.01) and IL-8 (P < 0.01) showing a potent anti-inflammatory activity. Silybin 0-7 C-C motif chemokine ligand 2 Homo sapiens 64-69 19439012-8 2009 LMP-420, a small molecular transcriptional inhibitor of both TNF-alpha and MCP-1 expression, did not reduce MTB-induced HIV-1 expression. 2-amino-6-chloro-9-((5-dihydroxyboryl)pentyl)purine 0-7 C-C motif chemokine ligand 2 Homo sapiens 75-80 19332124-2 2009 MCP-1, MIP-1alpha and GRO-alpha were significantly upregulated in the striatum 2-3 days following QA-induced lesioning, correlating with maximum SVZ-derived progenitor cell recruitment into the lesioned striatum. Quinolinic Acid 98-100 C-C motif chemokine ligand 2 Homo sapiens 0-5 19354228-1 2009 Rate constants and activation parameters are reported for additions of CCl(2) to methyl acrylate, acrylonitrile, and alpha-chloroacrylonitrile. methyl acrylate 81-96 C-C motif chemokine ligand 2 Homo sapiens 71-76 19439372-3 2009 Thus, aluminum salts activate dendritic cells, monocytes and macrophages with enhanced expression of adhesion molecules CD54 and CD58 and co-stimulatory molecules CD40 and CD86, which are crucial in T cell activation; induce chemokines CCL2, CCL3, CCL4 and CXCL8, which mediate recruitment of inflammatory cells at the site of vaccination; and stimulate cytokines crucial in the innate immune response. aluminum salts 6-20 C-C motif chemokine ligand 2 Homo sapiens 236-240 18952226-8 2009 Cytokine stimulation of cultured vSMCs induced vigorous production of the key chemotactant MCP-1, the expression of which was PKCdelta dependent. vsmcs 33-38 C-C motif chemokine ligand 2 Homo sapiens 91-96 19354228-1 2009 Rate constants and activation parameters are reported for additions of CCl(2) to methyl acrylate, acrylonitrile, and alpha-chloroacrylonitrile. Acrylonitrile 98-111 C-C motif chemokine ligand 2 Homo sapiens 71-76 19354228-1 2009 Rate constants and activation parameters are reported for additions of CCl(2) to methyl acrylate, acrylonitrile, and alpha-chloroacrylonitrile. 2-chloroacrylonitrile 117-142 C-C motif chemokine ligand 2 Homo sapiens 71-76 19354228-2 2009 The results reveal latent nucleophilicity in the addition of CCl(2) to alpha-chloroacrylonitrile, a conclusion supported by theoretical studies of the cyclopropanation reaction transition state. 2-chloroacrylonitrile 71-96 C-C motif chemokine ligand 2 Homo sapiens 61-66 19048368-5 2009 Activation of intracellular cyclic adenosine monophosphate or protein kinase C with forskolin and phorbol 12-myristate 13-acetate, respectively, was able to completely abolish the MCP-1-induced migration. Cyclic AMP 28-58 C-C motif chemokine ligand 2 Homo sapiens 180-185 19252096-8 2009 The release of MCP-1 by late EPCs was markedly reduced by simvastatin treatment of the cells. Simvastatin 58-69 C-C motif chemokine ligand 2 Homo sapiens 15-20 19404962-14 2009 AG-490 suppressed OSM-stimulated activation of STAT-1/3 and synthesis of CCL2 in vitro and diminished the severity of CIA and the number of CCL2-synthesizing osteoblasts in vivo. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 0-6 C-C motif chemokine ligand 2 Homo sapiens 73-77 19404962-14 2009 AG-490 suppressed OSM-stimulated activation of STAT-1/3 and synthesis of CCL2 in vitro and diminished the severity of CIA and the number of CCL2-synthesizing osteoblasts in vivo. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 0-6 C-C motif chemokine ligand 2 Homo sapiens 140-144 19048368-5 2009 Activation of intracellular cyclic adenosine monophosphate or protein kinase C with forskolin and phorbol 12-myristate 13-acetate, respectively, was able to completely abolish the MCP-1-induced migration. Colforsin 84-93 C-C motif chemokine ligand 2 Homo sapiens 180-185 19048368-5 2009 Activation of intracellular cyclic adenosine monophosphate or protein kinase C with forskolin and phorbol 12-myristate 13-acetate, respectively, was able to completely abolish the MCP-1-induced migration. Tetradecanoylphorbol Acetate 98-129 C-C motif chemokine ligand 2 Homo sapiens 180-185 19361458-6 2009 Circulating MCP-1 concentrations correlated with serum triglycerides (r=0.4, p=0.001) and also correlated with serum triglyceride concentrations, after adjusting for age and obesity, in postmenopausal women. Triglycerides 55-68 C-C motif chemokine ligand 2 Homo sapiens 12-17 19361458-6 2009 Circulating MCP-1 concentrations correlated with serum triglycerides (r=0.4, p=0.001) and also correlated with serum triglyceride concentrations, after adjusting for age and obesity, in postmenopausal women. Triglycerides 55-67 C-C motif chemokine ligand 2 Homo sapiens 12-17 19241441-5 2009 Evodiamine and rutaecarpine decreased the LIGHT-induced production of ROS, IL-8, monocyte chemoattractant protein-1 (MCP-1), TNF-alpha, and IL-6, as well as the expression of chemokine receptor (CCR) 1, CCR2 and ICAM-1 and the phosphorylation of the ERK 1/2 and p38 MAPK. evodiamine 0-10 C-C motif chemokine ligand 2 Homo sapiens 81-115 19241441-5 2009 Evodiamine and rutaecarpine decreased the LIGHT-induced production of ROS, IL-8, monocyte chemoattractant protein-1 (MCP-1), TNF-alpha, and IL-6, as well as the expression of chemokine receptor (CCR) 1, CCR2 and ICAM-1 and the phosphorylation of the ERK 1/2 and p38 MAPK. evodiamine 0-10 C-C motif chemokine ligand 2 Homo sapiens 117-122 19259948-4 2009 Previous studies have shown that anti-CCL2 antibodies given in combination with docetaxel were able to induce tumor regression in a pre-clinical prostate cancer model. Docetaxel 80-89 C-C motif chemokine ligand 2 Homo sapiens 38-42 19241441-5 2009 Evodiamine and rutaecarpine decreased the LIGHT-induced production of ROS, IL-8, monocyte chemoattractant protein-1 (MCP-1), TNF-alpha, and IL-6, as well as the expression of chemokine receptor (CCR) 1, CCR2 and ICAM-1 and the phosphorylation of the ERK 1/2 and p38 MAPK. rutecarpine 15-27 C-C motif chemokine ligand 2 Homo sapiens 81-115 19241441-5 2009 Evodiamine and rutaecarpine decreased the LIGHT-induced production of ROS, IL-8, monocyte chemoattractant protein-1 (MCP-1), TNF-alpha, and IL-6, as well as the expression of chemokine receptor (CCR) 1, CCR2 and ICAM-1 and the phosphorylation of the ERK 1/2 and p38 MAPK. rutecarpine 15-27 C-C motif chemokine ligand 2 Homo sapiens 117-122 19569526-6 2009 We propose that Ingramon might interfere with MCP-1-heparin/heparan sulphate binding on cell surface. Heparin 52-59 C-C motif chemokine ligand 2 Homo sapiens 46-51 19569526-6 2009 We propose that Ingramon might interfere with MCP-1-heparin/heparan sulphate binding on cell surface. Heparitin Sulfate 60-76 C-C motif chemokine ligand 2 Homo sapiens 46-51 19563733-5 2009 Furthermore, TNF-alpha-induced MCP-1 and IL-8 mRNA expression levels were also attenuated by pretreatment with EZS. 1-[1-(4-fluorobenzyl)-2-methyl-1H-imidazol-4-yl]-1-ethanone 111-114 C-C motif chemokine ligand 2 Homo sapiens 31-36 19339605-5 2009 MCP-1 upregulation by TNF-alpha was dose dependently inhibited by the JNK inhibitors SP600125 (anthra[1,9-cd]pyrazol-6(2H)-one) and D-JNKI-1. pyrazolanthrone 85-93 C-C motif chemokine ligand 2 Homo sapiens 0-5 19239904-3 2009 We found that sofalcone has a strong suppressive effect on the production of nitric oxide (NO), tumor necrosis factor (TNF)alpha, and monocyte chemoattractant protein (MCP)-1 in the culture medium of a coculture system containing RAW264.7 macrophages and 3T3-F442A adipocytes stimulated with lipopolysaccharide (LPS). sofalcone 14-23 C-C motif chemokine ligand 2 Homo sapiens 134-174 19222481-10 2009 In THP-1 cells, ezetimibe decreased monocyte chemoattractant protein-1-induced monocyte migration. Ezetimibe 16-25 C-C motif chemokine ligand 2 Homo sapiens 36-70 19245380-10 2009 The mean plasma MCP-1 concentration at 24 hours was 382.38 pg/mL in the SES group versus 329.04 pg/mL in the BMS group (P = 0.2). ses 72-75 C-C motif chemokine ligand 2 Homo sapiens 16-21 19397838-5 2009 In response to high glucose, several of these transcription factors regulate the gene encoding the profibrotic cytokine transforming growth factor beta, as well as genes for a range of other proteins implicated in inflammation and extracellular matrix turnover, including thrombospondin 1, the chemokine CCL2, osteopontin, fibronectin, decorin, plasminogen activator inhibitor 1 and aldose reductase. Glucose 20-27 C-C motif chemokine ligand 2 Homo sapiens 304-308 19185514-0 2009 Differentiation of 3-O-sulfated heparin disaccharide isomers: identification of structural aspects of the heparin CCL2 binding motif. 3-o-sulfated heparin disaccharide 19-52 C-C motif chemokine ligand 2 Homo sapiens 114-118 19185514-0 2009 Differentiation of 3-O-sulfated heparin disaccharide isomers: identification of structural aspects of the heparin CCL2 binding motif. Heparin 32-39 C-C motif chemokine ligand 2 Homo sapiens 114-118 19339605-5 2009 MCP-1 upregulation by TNF-alpha was dose dependently inhibited by the JNK inhibitors SP600125 (anthra[1,9-cd]pyrazol-6(2H)-one) and D-JNKI-1. pyrazolanthrone 95-126 C-C motif chemokine ligand 2 Homo sapiens 0-5 19339605-11 2009 Patch-clamp recordings in lamina II neurons of isolated spinal cord slices showed that MCP-1 not only enhanced spontaneous EPSCs but also potentiated NMDA- and AMPA-induced currents. N-Methylaspartate 150-154 C-C motif chemokine ligand 2 Homo sapiens 87-92 18705650-8 2009 Naringenin also markedly inhibited the secretion of interleukin (IL)-1alpha (by 59%), IL-23 (by 87%) and monocyte chemoattractant protein-1 (by 58%). naringenin 0-10 C-C motif chemokine ligand 2 Homo sapiens 105-139 19201463-5 2009 TNF-mediated stimulation of CCL2 secretion was completely inhibited by incubating the trophoblast cells with the p38-MAPK inhibitor SB203580, whereas CCL5 secretion was inhibited by treating the trophoblast cells with inhibitors specific for JNK (SP600125) and ERK kinase (U0126). SB 203580 132-140 C-C motif chemokine ligand 2 Homo sapiens 28-32 19185514-4 2009 Using this technique, we show that an octasaccharide with 11 sulfate groups with high affinity for inflammatory chemokine CCL2 does not contain 3-O-sulfated disaccharides. Octasaccharide 38-52 C-C motif chemokine ligand 2 Homo sapiens 122-126 19185514-4 2009 Using this technique, we show that an octasaccharide with 11 sulfate groups with high affinity for inflammatory chemokine CCL2 does not contain 3-O-sulfated disaccharides. Sulfates 61-68 C-C motif chemokine ligand 2 Homo sapiens 122-126 19279518-8 2009 Colestimide also significantly decreased the levels of urinary 8-iso-prostaglandin (PG) F2alpha (a marker of oxidative stress) and urinary monocyte chemoattractant protein-1 (MCP-1) (a marker of diabetic nephropathy). colestimide 0-11 C-C motif chemokine ligand 2 Homo sapiens 139-173 19279518-8 2009 Colestimide also significantly decreased the levels of urinary 8-iso-prostaglandin (PG) F2alpha (a marker of oxidative stress) and urinary monocyte chemoattractant protein-1 (MCP-1) (a marker of diabetic nephropathy). colestimide 0-11 C-C motif chemokine ligand 2 Homo sapiens 175-180 19158351-4 2009 At a similar concentration to that observed in peripheral blood after a meal, fructose induced production of monocyte chemotactic protein 1 (MCP-1) and reactive oxygen species in HK-2 cells. Fructose 78-86 C-C motif chemokine ligand 2 Homo sapiens 109-139 18606415-6 2009 Upon treatment with (R)-K-13675 at 0, 10, 20, 50 and 100nM, with the inflammatory markers at 0nM as 100 (arbitrary units), MCP-1 levels were significantly suppressed (94+/-9, 88+/-2, 80+/-5 and 74+/-11, respectively). (R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid 20-31 C-C motif chemokine ligand 2 Homo sapiens 123-128 19158351-4 2009 At a similar concentration to that observed in peripheral blood after a meal, fructose induced production of monocyte chemotactic protein 1 (MCP-1) and reactive oxygen species in HK-2 cells. Fructose 78-86 C-C motif chemokine ligand 2 Homo sapiens 141-146 19158351-8 2009 Fructose increased intracellular uric acid, and uric acid induced production of MCP-1 as well. Uric Acid 48-57 C-C motif chemokine ligand 2 Homo sapiens 80-85 19147409-2 2009 Polymorphisms in two of these genes, namely NOS2A and CCL2, have been associated with TB in various populations. Terbium 86-88 C-C motif chemokine ligand 2 Homo sapiens 54-58 19034671-9 2009 In vitro studies demonstrated that MCP-1 increased BMM migration across an artificial BBB, and the MCP-1-induced BMM migration was blocked by tetraethylammonium, a voltage-gated K+ channel blocker. Tetraethylammonium 142-160 C-C motif chemokine ligand 2 Homo sapiens 35-40 19034671-9 2009 In vitro studies demonstrated that MCP-1 increased BMM migration across an artificial BBB, and the MCP-1-induced BMM migration was blocked by tetraethylammonium, a voltage-gated K+ channel blocker. Tetraethylammonium 142-160 C-C motif chemokine ligand 2 Homo sapiens 99-104 19151033-7 2009 RESULTS: Treatment with simvastatin or atorvastatin decreased CRP-induced release of CCL2, CCL3 and CCL4. Simvastatin 24-35 C-C motif chemokine ligand 2 Homo sapiens 85-89 19151033-7 2009 RESULTS: Treatment with simvastatin or atorvastatin decreased CRP-induced release of CCL2, CCL3 and CCL4. Atorvastatin 39-51 C-C motif chemokine ligand 2 Homo sapiens 85-89 19218094-7 2009 Sulodexide caused the inhibition of the intracellular generation of free radicals in a dose-dependent manner (maximally by 32%, P < 0.01), as well as the inhibition of MCP-1 (maximally by 60%, P < 0.001) and IL-6 (maximally by 69%, P < 0.01). glucuronyl glucosamine glycan sulfate 0-10 C-C motif chemokine ligand 2 Homo sapiens 171-176 19218094-8 2009 Cells cultured in a medium with glucose 30 mmol/L generated more free radicals (+20%, P < 0.05) and released more MCP-1 (+113%, P < 0.001) and IL-6 (+26%, P < 0.05). Glucose 32-39 C-C motif chemokine ligand 2 Homo sapiens 117-122 19147409-3 2009 To investigate a possible association of gene variants with TB in the South African Coloured population we genotyped SNPs from NOS2A and CCL2 in over 800 TB cases and controls. Terbium 154-156 C-C motif chemokine ligand 2 Homo sapiens 137-141 19068240-6 2009 Plasma MCP-1 correlated negatively with the ratio of femoral artery diameter to lean leg mass (b=-0.42, P=0.009) and positively with serum triglycerides (b=0.46, P=0.005). Triglycerides 139-152 C-C motif chemokine ligand 2 Homo sapiens 7-12 19179025-9 2009 Serum concentrations of IL-8, IL-10, macrophage inflammatory protein (MIP)-1beta and monocyte chemoattractant protein-1 in women treated with paroxetine decreased significantly. Paroxetine 142-152 C-C motif chemokine ligand 2 Homo sapiens 85-119 19243600-8 2009 RESULTS: Rosiglitazone reduced plasma MCP1 and hsCRP concentrations in diabetic patients (-9.5 +/- 5.3 pg/mL, p = 0.043 and -1.1 +/- 0.3 mg/L p = 0.003), respectively). Rosiglitazone 9-22 C-C motif chemokine ligand 2 Homo sapiens 38-42 18489909-5 2009 Quercetin was able to reduce TNFalpha-induced upregulation of VCAM-1, ICAM-1 and MCP-1 at both the protein and transcript (mRNA) level in HUASMC. Quercetin 0-9 C-C motif chemokine ligand 2 Homo sapiens 81-86 19228389-0 2009 Influence of HFE variants and cellular iron on monocyte chemoattractant protein-1. Iron 39-43 C-C motif chemokine ligand 2 Homo sapiens 47-81 19228389-6 2009 The influence of cellular iron secretion on the potent chemokine monocyte chemoattractant protein-1 (MCP-1) was assessed using ferric ammonium citrate and the iron chelator, desferroxamine. Iron 26-30 C-C motif chemokine ligand 2 Homo sapiens 65-99 19228389-6 2009 The influence of cellular iron secretion on the potent chemokine monocyte chemoattractant protein-1 (MCP-1) was assessed using ferric ammonium citrate and the iron chelator, desferroxamine. Iron 26-30 C-C motif chemokine ligand 2 Homo sapiens 101-106 19228389-6 2009 The influence of cellular iron secretion on the potent chemokine monocyte chemoattractant protein-1 (MCP-1) was assessed using ferric ammonium citrate and the iron chelator, desferroxamine. ferric ammonium citrate 127-150 C-C motif chemokine ligand 2 Homo sapiens 65-99 19228389-6 2009 The influence of cellular iron secretion on the potent chemokine monocyte chemoattractant protein-1 (MCP-1) was assessed using ferric ammonium citrate and the iron chelator, desferroxamine. ferric ammonium citrate 127-150 C-C motif chemokine ligand 2 Homo sapiens 101-106 19228389-6 2009 The influence of cellular iron secretion on the potent chemokine monocyte chemoattractant protein-1 (MCP-1) was assessed using ferric ammonium citrate and the iron chelator, desferroxamine. Iron 159-163 C-C motif chemokine ligand 2 Homo sapiens 65-99 19228389-6 2009 The influence of cellular iron secretion on the potent chemokine monocyte chemoattractant protein-1 (MCP-1) was assessed using ferric ammonium citrate and the iron chelator, desferroxamine. Iron 159-163 C-C motif chemokine ligand 2 Homo sapiens 101-106 19228389-6 2009 The influence of cellular iron secretion on the potent chemokine monocyte chemoattractant protein-1 (MCP-1) was assessed using ferric ammonium citrate and the iron chelator, desferroxamine. Deferoxamine 174-188 C-C motif chemokine ligand 2 Homo sapiens 65-99 19228389-6 2009 The influence of cellular iron secretion on the potent chemokine monocyte chemoattractant protein-1 (MCP-1) was assessed using ferric ammonium citrate and the iron chelator, desferroxamine. Deferoxamine 174-188 C-C motif chemokine ligand 2 Homo sapiens 101-106 19228389-10 2009 We further examined the relationship between iron and MCP-1 and found MCP-1 secretion tightly associated with intracellular iron status. Iron 45-49 C-C motif chemokine ligand 2 Homo sapiens 54-59 19228389-10 2009 We further examined the relationship between iron and MCP-1 and found MCP-1 secretion tightly associated with intracellular iron status. Iron 45-49 C-C motif chemokine ligand 2 Homo sapiens 70-75 19228389-10 2009 We further examined the relationship between iron and MCP-1 and found MCP-1 secretion tightly associated with intracellular iron status. Iron 124-128 C-C motif chemokine ligand 2 Homo sapiens 70-75 19228389-12 2009 Moreover, HFE genotype was a factor in the effect of minocycline, a multifaceted antibiotic used in treating a number of neurologic conditions associated with inflammation, on MCP-1 secretion. Minocycline 53-64 C-C motif chemokine ligand 2 Homo sapiens 176-181 19228389-15 2009 Finally, these data demonstrate a pharmacogenetic effect of HFE polymorphisms on the ability of minocycline to inhibit MCP-1 secretion. Minocycline 96-107 C-C motif chemokine ligand 2 Homo sapiens 119-124 19211873-6 2009 Parallel but distinct extracellular signal-regulated kinase (ERK)/cAMP response element-binding protein (CREB) and Akt/nuclear factor kappaB (NF-kappaB) pathways were involved in the CCL2-mediated neuroprotection. Cyclic AMP 66-70 C-C motif chemokine ligand 2 Homo sapiens 183-187 18979300-5 2009 RESULTS: In combination with aldosterone, spironolactone, drospirenone, progesterone and R5020 were able to inhibit the aldosterone-induced increase in MCP-1 concentration, the effect being greatest for spironolactone. Aldosterone 29-40 C-C motif chemokine ligand 2 Homo sapiens 152-157 18979300-5 2009 RESULTS: In combination with aldosterone, spironolactone, drospirenone, progesterone and R5020 were able to inhibit the aldosterone-induced increase in MCP-1 concentration, the effect being greatest for spironolactone. Spironolactone 42-56 C-C motif chemokine ligand 2 Homo sapiens 152-157 19032551-7 2009 In the early phase of sevoflurane post-conditioning expression of TNF-alpha, CINC-1, MIP-2 and MCP-1 was attenuated, leading to a diminished chemotaxis reaction for neutrophils. Sevoflurane 22-33 C-C motif chemokine ligand 2 Homo sapiens 95-100 18979300-5 2009 RESULTS: In combination with aldosterone, spironolactone, drospirenone, progesterone and R5020 were able to inhibit the aldosterone-induced increase in MCP-1 concentration, the effect being greatest for spironolactone. drospirenone 58-70 C-C motif chemokine ligand 2 Homo sapiens 152-157 18979300-5 2009 RESULTS: In combination with aldosterone, spironolactone, drospirenone, progesterone and R5020 were able to inhibit the aldosterone-induced increase in MCP-1 concentration, the effect being greatest for spironolactone. Progesterone 72-84 C-C motif chemokine ligand 2 Homo sapiens 152-157 18979300-5 2009 RESULTS: In combination with aldosterone, spironolactone, drospirenone, progesterone and R5020 were able to inhibit the aldosterone-induced increase in MCP-1 concentration, the effect being greatest for spironolactone. Aldosterone 120-131 C-C motif chemokine ligand 2 Homo sapiens 152-157 18979300-5 2009 RESULTS: In combination with aldosterone, spironolactone, drospirenone, progesterone and R5020 were able to inhibit the aldosterone-induced increase in MCP-1 concentration, the effect being greatest for spironolactone. Spironolactone 203-217 C-C motif chemokine ligand 2 Homo sapiens 152-157 19334566-5 2009 The levels of NO and MCP-1 released by the macrophages co-cultured with Ti-O were lower when compared with those released by macrophages co-cultured with SS. titanium dioxide 72-76 C-C motif chemokine ligand 2 Homo sapiens 21-26 24692827-12 2009 CONCLUSION: Preemptive IV lornoxicam treatment was associated with attenuation of the plasma concentrations of MCP-1 and SDF-1alpha immediately after and 24 hours after hysterectomy and was associated with more rapid resolution to near-baseline concentrations of both cytokines in these patients compared with controls; however, it was not associated with significantly reducing epidural morphine consumption. lornoxicam 26-36 C-C motif chemokine ligand 2 Homo sapiens 111-116 19411809-6 2009 However, a trend towards a dose-dependent biphasic effect was observed for IL- 6, IL-10 and MCP-1 with reduced immune mediator levels at low and increased/unaltered levels at higher somatostatin or octreotide concentrations. Octreotide 198-208 C-C motif chemokine ligand 2 Homo sapiens 92-97 18954908-6 2009 Inhibition of Pyk2 activity using a pharmacological inhibitor, Tyrphostin A9 significantly attenuated LPS-induced Pyk2 tyrosine phosphorylation, p38 MAP kinase (MAPK) activation, NF-kappaB activation, and MCP-1 expression. tyrphostin A9 63-76 C-C motif chemokine ligand 2 Homo sapiens 205-210 19229322-5 2009 Our present findings demonstrate a rapid and HMB-PP-dependent crosstalk between Vgamma9/Vdelta2 T cells and autologous monocytes that results in the immediate production of inflammatory mediators including the cytokines interleukin (IL)-6, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and oncostatin M (OSM); the chemokines CCL2, CXCL8, and CXCL10; and TNF-related apoptosis-inducing ligand (TRAIL). 4-hydroxy-3-methylbut-2-enyl pyrophosphate 45-51 C-C motif chemokine ligand 2 Homo sapiens 338-342 19129402-0 2009 Astrocyte-derived MCP-1 mediates neuroprotective effects of noradrenaline. Norepinephrine 60-73 C-C motif chemokine ligand 2 Homo sapiens 18-23 19124762-3 2009 Priming of the cells with ER stress inducers (tunicamycin, thapsigargin, A23187, and AB5 subtilase cytotoxin) caused blunted induction of MCP-1 in response to TNF-alpha, IL-1beta, macrophage-derived factors, or bystander macrophages. Tunicamycin 46-57 C-C motif chemokine ligand 2 Homo sapiens 138-143 19124762-3 2009 Priming of the cells with ER stress inducers (tunicamycin, thapsigargin, A23187, and AB5 subtilase cytotoxin) caused blunted induction of MCP-1 in response to TNF-alpha, IL-1beta, macrophage-derived factors, or bystander macrophages. Thapsigargin 59-71 C-C motif chemokine ligand 2 Homo sapiens 138-143 19124762-3 2009 Priming of the cells with ER stress inducers (tunicamycin, thapsigargin, A23187, and AB5 subtilase cytotoxin) caused blunted induction of MCP-1 in response to TNF-alpha, IL-1beta, macrophage-derived factors, or bystander macrophages. Calcimycin 73-79 C-C motif chemokine ligand 2 Homo sapiens 138-143 19129402-4 2009 NA increased activation of an MCP-1 promoter driving luciferase expression, which was replicated by beta-adrenergic receptor agonists and a cAMP analog, and blocked by a specific beta2-adrenergic receptor antagonist. Cyclic AMP 140-144 C-C motif chemokine ligand 2 Homo sapiens 30-35 19129402-5 2009 In primary neurons, addition of MCP-1 reduced NMDA-dependent glutamate release as well as glutamate-dependent Ca(2+) entry. N-Methylaspartate 46-50 C-C motif chemokine ligand 2 Homo sapiens 32-37 19129402-5 2009 In primary neurons, addition of MCP-1 reduced NMDA-dependent glutamate release as well as glutamate-dependent Ca(2+) entry. Glutamic Acid 61-70 C-C motif chemokine ligand 2 Homo sapiens 32-37 19129402-5 2009 In primary neurons, addition of MCP-1 reduced NMDA-dependent glutamate release as well as glutamate-dependent Ca(2+) entry. Glutamic Acid 90-99 C-C motif chemokine ligand 2 Homo sapiens 32-37 19129402-6 2009 Similarly, conditioned media from NA-treated astrocytes reduced glutamate release, an effect that was blocked by neutralizing antibody to MCP-1, whereas MCP-1 dose-dependently reduced neuronal damage attributable to NMDA or to glutamate. Glutamic Acid 64-73 C-C motif chemokine ligand 2 Homo sapiens 138-143 19129402-6 2009 Similarly, conditioned media from NA-treated astrocytes reduced glutamate release, an effect that was blocked by neutralizing antibody to MCP-1, whereas MCP-1 dose-dependently reduced neuronal damage attributable to NMDA or to glutamate. N-Methylaspartate 216-220 C-C motif chemokine ligand 2 Homo sapiens 153-158 19129402-6 2009 Similarly, conditioned media from NA-treated astrocytes reduced glutamate release, an effect that was blocked by neutralizing antibody to MCP-1, whereas MCP-1 dose-dependently reduced neuronal damage attributable to NMDA or to glutamate. Glutamic Acid 227-236 C-C motif chemokine ligand 2 Homo sapiens 153-158 18973761-4 2009 KEY FINDINGS: We found increased inflammation and secretion of the chemokines IL-6, MCP-1 and MIP-alpha 2 weeks after SiO2 application, and increased lung fibrosis after 3 months. Silicon Dioxide 118-122 C-C motif chemokine ligand 2 Homo sapiens 84-89 19129402-7 2009 MCP-1 significantly reduced lactate dehydrogenase release from neurons after oxygen-glucose deprivation (OGD) and prevented the loss of ATP levels that occurred after OGD or treatment with glutamate. oxygen-glucose 77-91 C-C motif chemokine ligand 2 Homo sapiens 0-5 19129402-7 2009 MCP-1 significantly reduced lactate dehydrogenase release from neurons after oxygen-glucose deprivation (OGD) and prevented the loss of ATP levels that occurred after OGD or treatment with glutamate. Adenosine Triphosphate 136-139 C-C motif chemokine ligand 2 Homo sapiens 0-5 19129402-7 2009 MCP-1 significantly reduced lactate dehydrogenase release from neurons after oxygen-glucose deprivation (OGD) and prevented the loss of ATP levels that occurred after OGD or treatment with glutamate. Glutamic Acid 189-198 C-C motif chemokine ligand 2 Homo sapiens 0-5 19225232-9 2009 Valsartan blocked the AII-induced mRNA expression of proinflammatory genes (i.e. MCP-1, LIF and COX-2) maintained in normal and high glucose. Valsartan 0-9 C-C motif chemokine ligand 2 Homo sapiens 81-86 19098936-6 2009 Both 15d-PGJ2 at 2.5 and 5 micromol/L and TGL at 2.5 micromol/L exhibited inhibitory effects on TGF-beta1-induced MCP-1 expression. 15-deoxyprostaglandin J2 5-13 C-C motif chemokine ligand 2 Homo sapiens 114-119 19098936-6 2009 Both 15d-PGJ2 at 2.5 and 5 micromol/L and TGL at 2.5 micromol/L exhibited inhibitory effects on TGF-beta1-induced MCP-1 expression. Troglitazone 42-45 C-C motif chemokine ligand 2 Homo sapiens 114-119 20069129-0 2009 Reduction of monocyte chemoattractant protein-1 and interleukin-8 levels by ticlopidine in TNF-alpha stimulated human umbilical vein endothelial cells. Ticlopidine 76-87 C-C motif chemokine ligand 2 Homo sapiens 13-47 18703532-6 2009 Furthermore, cilostazol attenuated the TNFalpha-induced gene expression of various pro-inflammatory and cell adhesion molecules, such as vascular cell adhesion molecule-1, E-selectin, intercellular adhesion molecule-1, monocyte chemoattractant protein-1 (MCP-1), and PECAM-1 in HUVEC. Cilostazol 13-23 C-C motif chemokine ligand 2 Homo sapiens 219-253 18703532-6 2009 Furthermore, cilostazol attenuated the TNFalpha-induced gene expression of various pro-inflammatory and cell adhesion molecules, such as vascular cell adhesion molecule-1, E-selectin, intercellular adhesion molecule-1, monocyte chemoattractant protein-1 (MCP-1), and PECAM-1 in HUVEC. Cilostazol 13-23 C-C motif chemokine ligand 2 Homo sapiens 255-260 18973470-3 2009 show that a 4-week treatment course with the lipophilic statin atorvastatin ameliorates left ventricular remodelling and function, reduces serum levels of TNF-alpha (tumour necrosis factor-alpha), IL (interleukin)-6 and MCP-1 (monocyte chemoattractant protein-1), and increases both serum and myocardial levels of IL-10. Atorvastatin 63-75 C-C motif chemokine ligand 2 Homo sapiens 220-225 18973470-3 2009 show that a 4-week treatment course with the lipophilic statin atorvastatin ameliorates left ventricular remodelling and function, reduces serum levels of TNF-alpha (tumour necrosis factor-alpha), IL (interleukin)-6 and MCP-1 (monocyte chemoattractant protein-1), and increases both serum and myocardial levels of IL-10. Atorvastatin 63-75 C-C motif chemokine ligand 2 Homo sapiens 227-261 19218821-0 2009 Cysteinyl leukotrienes induce monocyte chemoattractant protein-1 in human monocyte/macrophages via mitogen-activated protein kinase and nuclear factor-kappaB pathways. cysteinyl-leukotriene 0-22 C-C motif chemokine ligand 2 Homo sapiens 30-64 19218821-1 2009 BACKGROUND: We have previously demonstrated that cysteinyl leukotriene (CysLT) induced monocyte chemoattractant protein-1 (MCP-1) production in monocytes/macrophages. cysteinyl-leukotriene 49-70 C-C motif chemokine ligand 2 Homo sapiens 87-121 19218821-1 2009 BACKGROUND: We have previously demonstrated that cysteinyl leukotriene (CysLT) induced monocyte chemoattractant protein-1 (MCP-1) production in monocytes/macrophages. cysteinyl-leukotriene 49-70 C-C motif chemokine ligand 2 Homo sapiens 123-128 19218821-6 2009 Pretreatment with the ERK1/2 inhibitor PD98059 and JNK inhibitor SP600125 attenuated MCP-1 production by CysLTs. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 39-46 C-C motif chemokine ligand 2 Homo sapiens 85-90 19218821-6 2009 Pretreatment with the ERK1/2 inhibitor PD98059 and JNK inhibitor SP600125 attenuated MCP-1 production by CysLTs. pyrazolanthrone 65-73 C-C motif chemokine ligand 2 Homo sapiens 85-90 19218821-8 2009 Pretreatment with the NF-kappaB inhibitors caffeic acid phenylethyl ester and MG-132 inhibited MCP-1 production by CysLTs. caffeic acid phenethyl ester 43-73 C-C motif chemokine ligand 2 Homo sapiens 95-100 19218821-8 2009 Pretreatment with the NF-kappaB inhibitors caffeic acid phenylethyl ester and MG-132 inhibited MCP-1 production by CysLTs. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 78-84 C-C motif chemokine ligand 2 Homo sapiens 95-100 18495130-7 2009 Pretreatment of human monocytes with candesartan significantly decreased Pam3CSK4 or LPS induced TLR2 and TLR4 expression of both mRNA and protein levels (P<0.05 vs. control) along with decrease in the activity of NF-kappaB and the expression of IL-1beta, IL-6, TNF-alpha, and MCP-1. candesartan 37-48 C-C motif chemokine ligand 2 Homo sapiens 280-285 19756411-3 2009 The aim of this study was to investigate the effect of intermittent high glucose on the expression of IL-18, MCP-1, and PAI-1 and adiponectin in 3T3-L1 adipocytes. Glucose 73-80 C-C motif chemokine ligand 2 Homo sapiens 109-114 19756411-6 2009 Stable high glucose significantly increased expression and secretion of IL-18, MCP-1, and PAI-1, and reduced adiponectin expression and secretion compared to normal glucose conditions.These effects were significantly greater under intermittent high glucose conditions compared to stable high glucose. Glucose 12-19 C-C motif chemokine ligand 2 Homo sapiens 79-84 19641312-9 2009 CONCLUSION: Triflusal modulates additional mechanisms to those of aspirin [pro-inflammatory (IL-6) and chemokine (MIP-1 and MCP-1) pathways] that could participate in the ischemic damage process following human acute stroke. triflusal 12-21 C-C motif chemokine ligand 2 Homo sapiens 124-129 19641312-9 2009 CONCLUSION: Triflusal modulates additional mechanisms to those of aspirin [pro-inflammatory (IL-6) and chemokine (MIP-1 and MCP-1) pathways] that could participate in the ischemic damage process following human acute stroke. Aspirin 66-73 C-C motif chemokine ligand 2 Homo sapiens 124-129 18663553-4 2009 Three months therapy with leflunomide caused reduction in serum RANTES and MCP-1 (in both cases, p < 0.001) levels. Leflunomide 26-37 C-C motif chemokine ligand 2 Homo sapiens 75-80 19273214-6 2009 The cleaved form of suPAR binds and activates the fMLP-Rs and regulates the activity of MCP-1, RANTES and SDF1 receptors. supar 20-25 C-C motif chemokine ligand 2 Homo sapiens 88-93 19218821-9 2009 Pranlukast inhibited phosphorylation of ERK1/2 and JNK, NF-kappaB activation, and the MCP-1 production induced by CysLTs. pranlukast 0-10 C-C motif chemokine ligand 2 Homo sapiens 86-91 18690522-5 2009 In addition, the 30-kDa Ag activated mRNA and protein expression of CXCL8 and CCL2 in human primary monocytes through nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent ROS generation. NADP 118-161 C-C motif chemokine ligand 2 Homo sapiens 78-82 20069129-8 2009 These results suggest that ticlopidine decreased TNF-alpha induced MCP-1, IL-8, and VCAM-1 levels in HUVECs, and monocyte adhesion. Ticlopidine 27-38 C-C motif chemokine ligand 2 Homo sapiens 67-72 18690522-5 2009 In addition, the 30-kDa Ag activated mRNA and protein expression of CXCL8 and CCL2 in human primary monocytes through nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent ROS generation. Reactive Oxygen Species 188-191 C-C motif chemokine ligand 2 Homo sapiens 78-82 18690522-10 2009 CONCLUSION: These results indicate that TLR2-ROS signaling plays a crucial role in the 30-kDa Ag-mediated expression of CXCL8 and CCL2 in human monocytes. Reactive Oxygen Species 45-48 C-C motif chemokine ligand 2 Homo sapiens 130-134 19118698-7 2009 RESULTS: Vitreous fluid levels of VEGF, ICAM-1, IL-6, and MCP-1 were significantly higher in patients with DME than in nondiabetic patients (P<0.05, all respectively) or diabetic patients without retinopathy (P<0.05, all respectively). dme 107-110 C-C motif chemokine ligand 2 Homo sapiens 58-63 19118698-9 2009 Vitreous levels of VEGF, ICAM-1, IL-6, and MCP-1 were significantly higher in patients with hyperfluorescent DME than in those with minimally fluorescent DME (P = 0.0018, P = 0.0022, P = 0.0032, and P = 0.0053, respectively). dme 109-112 C-C motif chemokine ligand 2 Homo sapiens 43-48 19439918-12 2009 However, the detectable concentrations of MCP-1 and MIP-1alpha were significantly reduced in the sputum of DTT-treated samples. Dithiothreitol 107-110 C-C motif chemokine ligand 2 Homo sapiens 42-47 19340290-10 2009 CFP10-induced CCL2 was higher in PTB than LNTB patients. lntb 42-46 C-C motif chemokine ligand 2 Homo sapiens 14-18 18840498-6 2008 Ethanol decreased LPS-stimulated IL-6, IL-8, TNF-alpha, and MCP-1 dose-dependently (all p<0.01). Ethanol 0-7 C-C motif chemokine ligand 2 Homo sapiens 60-65 19439918-3 2009 OBJECTIVES: Our study was designed to investigate whether DTT affects the detection of monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1alpha and interleukin (IL)-10. Dithiothreitol 58-61 C-C motif chemokine ligand 2 Homo sapiens 87-127 19439918-9 2009 Sputum treated with DTT had higher total cell counts (p < 0.01) but lower levels of MCP-1 and MIP-1alpha (p < 0.02, p < 0.05) than that treated with PBS. Dithiothreitol 20-23 C-C motif chemokine ligand 2 Homo sapiens 87-92 18799930-0 2008 Rosmarinic acid down-regulates the LPS-induced production of monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha (MIP-1alpha) via the MAPK pathway in bone-marrow derived dendritic cells. rosmarinic acid 0-15 C-C motif chemokine ligand 2 Homo sapiens 61-95 18799930-0 2008 Rosmarinic acid down-regulates the LPS-induced production of monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha (MIP-1alpha) via the MAPK pathway in bone-marrow derived dendritic cells. rosmarinic acid 0-15 C-C motif chemokine ligand 2 Homo sapiens 97-102 18799930-1 2008 In the present study, we investigated whether rosmarinic acid, which has been suggested to exhibit anti-inflammatory properties, can suppress the expressions of monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha (MIP-1alpha) via the MAPK pathway in LPS-stimulated bone marrow-derived dendritic cells (BMDCs) in the presence of GM-CSF and IL-4 in media. rosmarinic acid 46-61 C-C motif chemokine ligand 2 Homo sapiens 161-195 18799930-1 2008 In the present study, we investigated whether rosmarinic acid, which has been suggested to exhibit anti-inflammatory properties, can suppress the expressions of monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha (MIP-1alpha) via the MAPK pathway in LPS-stimulated bone marrow-derived dendritic cells (BMDCs) in the presence of GM-CSF and IL-4 in media. rosmarinic acid 46-61 C-C motif chemokine ligand 2 Homo sapiens 197-202 18799930-5 2008 Rosmarinic acid also significantly reduced the expressions of MCP-1 and MIP-lalpha induced by LPS in BMDCs and inhibited LPS-induced activation of MAPK and the nuclear translocation of NF-kappaB. rosmarinic acid 0-15 C-C motif chemokine ligand 2 Homo sapiens 62-67 18951912-10 2009 Acrolein treatment led to activation and nuclear translocation of the transcription factor NF-kappaB and an increase in TNF-alpha, IL-6 and IL-8, but not MCP-1, mRNA. Acrolein 0-8 C-C motif chemokine ligand 2 Homo sapiens 154-159 19921973-9 2009 A concave quadratic equation described the associations between plasma venlafaxine concentrations and IL1beta (P=0.03), TNFalpha (P=0.09), and MCP-1 (P=0.02), suggesting that these biomarkers may have become selectively lowered in the serotonergic dose range of venlafaxine. Venlafaxine Hydrochloride 71-82 C-C motif chemokine ligand 2 Homo sapiens 143-148 19050284-0 2008 The 15-deoxy-delta 12,14-prostaglandin J2 suppresses monocyte chemoattractant protein-1 expression in IFN-gamma-stimulated astrocytes through induction of MAPK phosphatase-1. 15-deoxy-delta(12,14)-prostaglandin J2 4-41 C-C motif chemokine ligand 2 Homo sapiens 53-87 19050284-4 2008 In the present study, we focused on the inhibitory action of 15d-PGJ(2) on the chemokine MCP-1, which plays a key role in the initiation and progression of inflammation by recruiting inflammatory cells to lesion sites. 15d-pgj 61-68 C-C motif chemokine ligand 2 Homo sapiens 89-94 19050284-6 2008 The inhibitory effects of 15d-PGJ(2) on MCP-1 resulted from its actions on the transcription factors, AP-1 and specificity protein-1, which play key roles in IFN-gamma-induced MCP-1 expression in astrocytes. 15d-pgj 26-33 C-C motif chemokine ligand 2 Homo sapiens 40-45 19050284-6 2008 The inhibitory effects of 15d-PGJ(2) on MCP-1 resulted from its actions on the transcription factors, AP-1 and specificity protein-1, which play key roles in IFN-gamma-induced MCP-1 expression in astrocytes. 15d-pgj 26-33 C-C motif chemokine ligand 2 Homo sapiens 176-181 19050284-7 2008 Of interest, the negative effects of 15d-PGJ(2) on AP-1/specificity protein-1 signaling and the resulting inhibition of MCP-1 expression were mediated by MAPK phosphatase (MKP)-1 activity, which was induced by 15d-PGJ(2) in a peroxisome proliferator-activated receptor-independent manner. 15d-pgj 37-44 C-C motif chemokine ligand 2 Homo sapiens 120-125 19050284-7 2008 Of interest, the negative effects of 15d-PGJ(2) on AP-1/specificity protein-1 signaling and the resulting inhibition of MCP-1 expression were mediated by MAPK phosphatase (MKP)-1 activity, which was induced by 15d-PGJ(2) in a peroxisome proliferator-activated receptor-independent manner. 15d-pgj 210-217 C-C motif chemokine ligand 2 Homo sapiens 120-125 19050284-9 2008 Considering the importance of MCP-1 in inflammatory processes, our results suggest that 15d-PGJ(2) analogues may have therapeutic potential to attenuate inflammatory brain diseases by inducing MKP-1 expression. 15d-pgj 88-95 C-C motif chemokine ligand 2 Homo sapiens 30-35 19020780-6 2008 The results demonstrated that glucosamine but not N-acetylglucosamine suppressed TNF-alpha-induced expression of MCP-1 and ICAM-1 at both the mRNA and protein levels. Glucosamine 30-41 C-C motif chemokine ligand 2 Homo sapiens 113-118 18991443-1 2008 The first Friedel-Crafts reaction initiated by the direct generation of a carbocation at the C3 position of MCP 1,1-diesters through distal-bond cleavage was presented. friedel 10-17 C-C motif chemokine ligand 2 Homo sapiens 108-113 19034332-4 2008 In contrast, decreased MCP-1 plasma levels, NF-kappaB activation (EMSA) and MCP-1 mRNA expression (quantitative PCR) was only observed in blood from ATV+AML treated-patients. Atazanavir Sulfate 149-152 C-C motif chemokine ligand 2 Homo sapiens 23-28 18791174-4 2008 Effects of tunicamycin and thapsigargin on IL-1beta- and TNF-alpha-stimulated MCP-1 mRNA expression and protein production were further examined by RT-PCR and ELISA, respectively. Tunicamycin 11-22 C-C motif chemokine ligand 2 Homo sapiens 78-83 18791174-4 2008 Effects of tunicamycin and thapsigargin on IL-1beta- and TNF-alpha-stimulated MCP-1 mRNA expression and protein production were further examined by RT-PCR and ELISA, respectively. Thapsigargin 27-39 C-C motif chemokine ligand 2 Homo sapiens 78-83 18716605-3 2008 Genistein significantly decreased reactive oxygen species production, the expression of intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 proteins, as well as the translocation of the p65 subunit of nuclear factor-kappaB into the nucleus and the infiltration of macrophages, all of which were increased in the kidney by cisplatin treatment. Genistein 0-9 C-C motif chemokine ligand 2 Homo sapiens 126-160 18657352-0 2008 Effect of treatment with methylprednisolone on the serum levels of IL-12, IL-10 and CCL2 chemokine in patients with multiple sclerosis in relapse. Methylprednisolone 25-43 C-C motif chemokine ligand 2 Homo sapiens 84-88 18657352-5 2008 RESULTS: A significant increase of IL-10 and decrease of CCL2 serum levels was observed (p=0.0028 and 0.045 respectively) five days after the onset of steroid treatment but not after one month. Steroids 151-158 C-C motif chemokine ligand 2 Homo sapiens 57-61 18657352-7 2008 CONCLUSIONS: The clinical improvement of our MS patients with relapse following the treatment with methylprednisolone may be associated with an immediate but not a long-term modification of serum levels of IL-10 and CCL2. Methylprednisolone 99-117 C-C motif chemokine ligand 2 Homo sapiens 216-220 19034332-4 2008 In contrast, decreased MCP-1 plasma levels, NF-kappaB activation (EMSA) and MCP-1 mRNA expression (quantitative PCR) was only observed in blood from ATV+AML treated-patients. Atazanavir Sulfate 149-152 C-C motif chemokine ligand 2 Homo sapiens 76-81 18688800-5 2008 High glucose-induced MCP-1 and IL-8 mRNA expression levels also decreased by ABO. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 21-26 18826286-1 2008 Dichloro- and phenylchlorocarbene (CCl2 and PhCCl) add to cyclooctyne via a barrierless process (MP2/6-311+G*, B3LYP/6-311+G*, B3LYP/6-31G*) to yield the expected corresponding cyclopropene adducts. dichloro- and phenylchlorocarbene 0-33 C-C motif chemokine ligand 2 Homo sapiens 35-39 18976655-0 2008 Regulatory role of thioredoxin in homocysteine-induced monocyte chemoattractant protein-1 secretion in monocytes/macrophages. Homocysteine 34-46 C-C motif chemokine ligand 2 Homo sapiens 55-89 18976655-1 2008 We have previously shown that homocysteine (Hcy) can induce monocyte chemoattractant protein-1 (MCP-1) secretion via reactive oxygen species (ROS) in human monocytes. Homocysteine 30-42 C-C motif chemokine ligand 2 Homo sapiens 60-94 18976655-1 2008 We have previously shown that homocysteine (Hcy) can induce monocyte chemoattractant protein-1 (MCP-1) secretion via reactive oxygen species (ROS) in human monocytes. Homocysteine 30-42 C-C motif chemokine ligand 2 Homo sapiens 96-101 19132243-0 2008 High glucose conditions induce upregulation of fractalkine and monocyte chemotactic protein-1 in human smooth muscle cells. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 63-93 19132243-7 2008 Treatment of HG-exposed SMC with peroxisome proliferator-activated receptors alpha (PPARalpha) activators (fenofibrate and clofibrate) resulted in a reduction of mRNA and protein expression of MCP-1 and fractalkine. Fenofibrate 107-118 C-C motif chemokine ligand 2 Homo sapiens 193-214 19132243-7 2008 Treatment of HG-exposed SMC with peroxisome proliferator-activated receptors alpha (PPARalpha) activators (fenofibrate and clofibrate) resulted in a reduction of mRNA and protein expression of MCP-1 and fractalkine. Clofibrate 123-133 C-C motif chemokine ligand 2 Homo sapiens 193-214 18976655-1 2008 We have previously shown that homocysteine (Hcy) can induce monocyte chemoattractant protein-1 (MCP-1) secretion via reactive oxygen species (ROS) in human monocytes. Homocysteine 44-47 C-C motif chemokine ligand 2 Homo sapiens 60-94 18976655-1 2008 We have previously shown that homocysteine (Hcy) can induce monocyte chemoattractant protein-1 (MCP-1) secretion via reactive oxygen species (ROS) in human monocytes. Homocysteine 44-47 C-C motif chemokine ligand 2 Homo sapiens 96-101 18976655-1 2008 We have previously shown that homocysteine (Hcy) can induce monocyte chemoattractant protein-1 (MCP-1) secretion via reactive oxygen species (ROS) in human monocytes. Reactive Oxygen Species 117-140 C-C motif chemokine ligand 2 Homo sapiens 60-94 18976655-1 2008 We have previously shown that homocysteine (Hcy) can induce monocyte chemoattractant protein-1 (MCP-1) secretion via reactive oxygen species (ROS) in human monocytes. Reactive Oxygen Species 117-140 C-C motif chemokine ligand 2 Homo sapiens 96-101 18976655-1 2008 We have previously shown that homocysteine (Hcy) can induce monocyte chemoattractant protein-1 (MCP-1) secretion via reactive oxygen species (ROS) in human monocytes. Reactive Oxygen Species 142-145 C-C motif chemokine ligand 2 Homo sapiens 60-94 18976655-1 2008 We have previously shown that homocysteine (Hcy) can induce monocyte chemoattractant protein-1 (MCP-1) secretion via reactive oxygen species (ROS) in human monocytes. Reactive Oxygen Species 142-145 C-C motif chemokine ligand 2 Homo sapiens 96-101 18826286-1 2008 Dichloro- and phenylchlorocarbene (CCl2 and PhCCl) add to cyclooctyne via a barrierless process (MP2/6-311+G*, B3LYP/6-311+G*, B3LYP/6-31G*) to yield the expected corresponding cyclopropene adducts. Cyclooctyne 58-69 C-C motif chemokine ligand 2 Homo sapiens 35-39 18826286-1 2008 Dichloro- and phenylchlorocarbene (CCl2 and PhCCl) add to cyclooctyne via a barrierless process (MP2/6-311+G*, B3LYP/6-311+G*, B3LYP/6-31G*) to yield the expected corresponding cyclopropene adducts. cyclopropene 177-189 C-C motif chemokine ligand 2 Homo sapiens 35-39 18826286-2 2008 A three-dimensional potential energy surface (PES) for CCl2 addition to cyclooctyne (B3LYP/6-31G*) shows the formation of the cyclopropene product and also possible formation of a vinylcarbene. Cyclooctyne 72-83 C-C motif chemokine ligand 2 Homo sapiens 55-59 18826286-2 2008 A three-dimensional potential energy surface (PES) for CCl2 addition to cyclooctyne (B3LYP/6-31G*) shows the formation of the cyclopropene product and also possible formation of a vinylcarbene. cyclopropene 126-138 C-C motif chemokine ligand 2 Homo sapiens 55-59 18826286-2 2008 A three-dimensional potential energy surface (PES) for CCl2 addition to cyclooctyne (B3LYP/6-31G*) shows the formation of the cyclopropene product and also possible formation of a vinylcarbene. vinylcarbene 180-192 C-C motif chemokine ligand 2 Homo sapiens 55-59 18975306-10 2008 ACh significantly reduced the production of IL-6, CXCL8, CCL2, CCL3, CCL5, and granulocyte colony-stimulating factor by IL-1-stimulated FLS. Acetylcholine 0-3 C-C motif chemokine ligand 2 Homo sapiens 57-61 18697197-4 2008 Treatment of tumor cells with doxorubicin and cisplatin resulted in a substantial increase in the production of IL-6, CXCL8, CCL2, CCL5, BFGF, G-CSF and VEGF. Cisplatin 46-55 C-C motif chemokine ligand 2 Homo sapiens 125-129 18697197-4 2008 Treatment of tumor cells with doxorubicin and cisplatin resulted in a substantial increase in the production of IL-6, CXCL8, CCL2, CCL5, BFGF, G-CSF and VEGF. Doxorubicin 30-41 C-C motif chemokine ligand 2 Homo sapiens 125-129 18697197-6 2008 Treatment of tumor cells with doxorubicin and antibodies neutralizing G-CSF, CCL2 or CCL5 had higher inhibitory effects than each modality used alone. Doxorubicin 30-41 C-C motif chemokine ligand 2 Homo sapiens 77-81 18974575-7 2008 The urinary MCP-1 level was significantly higher in patients with micro and macroalbuminuria (167.41 +/- 50.23 and 630.87 +/- 318.10 ng/gm creatinine respectively) as compared with normoalbuminuric patients and healthy controls (63.85 +/- 21.15 and 61.50 +/- 24.81 ng/gm creatinine, p p 0.001), HbA1c (r= 0.55, p 0.001) and inversely with eGFR (r=-0.60, p< 0.001). Creatinine 139-149 C-C motif chemokine ligand 2 Homo sapiens 12-17 18949387-6 2008 Glucosamine but not N-acetylglucosamine suppressed the LL-37-induced expression of MCP-1 and ICAM-1 at both mRNA (p<0.05 at 0.1 mM) and protein levels (p<0.05 at 1 mM). Glucosamine 0-11 C-C motif chemokine ligand 2 Homo sapiens 83-88 18949387-8 2008 Of note, alloxan, an O-N-acetylglucosamine transferase inhibitor, which prevented the glucosamine-induced O-GlcNAc modification, abrogated the suppressive effect of glucosamine on MCP-1 and ICAM-1 expression (p<0.05 at 0.5 mM). Alloxan 9-16 C-C motif chemokine ligand 2 Homo sapiens 180-185 18949387-8 2008 Of note, alloxan, an O-N-acetylglucosamine transferase inhibitor, which prevented the glucosamine-induced O-GlcNAc modification, abrogated the suppressive effect of glucosamine on MCP-1 and ICAM-1 expression (p<0.05 at 0.5 mM). Glucosamine 86-97 C-C motif chemokine ligand 2 Homo sapiens 180-185 18784644-2 2008 Urinary MCP-1 protein and renal macrophage infiltration were each significantly but inversely correlated with serum 1,25(OH)2D levels. 1,25(oh)2d 116-126 C-C motif chemokine ligand 2 Homo sapiens 8-13 18974575-7 2008 The urinary MCP-1 level was significantly higher in patients with micro and macroalbuminuria (167.41 +/- 50.23 and 630.87 +/- 318.10 ng/gm creatinine respectively) as compared with normoalbuminuric patients and healthy controls (63.85 +/- 21.15 and 61.50 +/- 24.81 ng/gm creatinine, p p 0.001), HbA1c (r= 0.55, p 0.001) and inversely with eGFR (r=-0.60, p< 0.001). Creatinine 271-281 C-C motif chemokine ligand 2 Homo sapiens 12-17 18727697-7 2008 The transplant induced upregulation in the inflammatory mediators CCL2, IL-1 beta, IL-6 and TNF-alpha were mitigated by hydrogen. Hydrogen 120-128 C-C motif chemokine ligand 2 Homo sapiens 66-70 18821707-0 2008 Epigallocatechin-3-gallate diminishes CCL2 expression in human osteoblastic cells via up-regulation of phosphatidylinositol 3-Kinase/Akt/Raf-1 interaction: a potential therapeutic benefit for arthritis. epigallocatechin gallate 0-26 C-C motif chemokine ligand 2 Homo sapiens 38-42 18821707-10 2008 EMSA and ChIP assay revealed that EGCG attenuated activator protein 1 (AP-1)-CCL2 promoter interaction, possibly by reducing c-Fos synthesis. epigallocatechin gallate 34-38 C-C motif chemokine ligand 2 Homo sapiens 77-81 18821707-1 2008 OBJECTIVE: To assess the effects of epigallocatechin-3-gallate (EGCG) on oncostatin M (OSM)-induced CCL2 synthesis and the associated signaling pathways in human osteoblastic cells. epigallocatechin gallate 36-62 C-C motif chemokine ligand 2 Homo sapiens 100-104 18821707-12 2008 Administration of EGCG markedly diminished the severity of CIA, macrophage infiltration, and the amount of CCL2-synthesizing osteoblasts. epigallocatechin gallate 18-22 C-C motif chemokine ligand 2 Homo sapiens 107-111 18821707-1 2008 OBJECTIVE: To assess the effects of epigallocatechin-3-gallate (EGCG) on oncostatin M (OSM)-induced CCL2 synthesis and the associated signaling pathways in human osteoblastic cells. epigallocatechin gallate 64-68 C-C motif chemokine ligand 2 Homo sapiens 100-104 18821707-13 2008 CONCLUSION: By stimulating PI 3-kinase activity, EGCG promoted Akt/Raf-1 crosstalk, resulting in decreased AP-1 binding to CCL2 promoter, and finally reduced CCL2 production in osteoblasts. epigallocatechin gallate 49-53 C-C motif chemokine ligand 2 Homo sapiens 123-127 18821707-13 2008 CONCLUSION: By stimulating PI 3-kinase activity, EGCG promoted Akt/Raf-1 crosstalk, resulting in decreased AP-1 binding to CCL2 promoter, and finally reduced CCL2 production in osteoblasts. epigallocatechin gallate 49-53 C-C motif chemokine ligand 2 Homo sapiens 158-162 18821707-7 2008 RESULTS: EGCG inhibited OSM-stimulated CCL2 expression in primary human osteoblasts and MG-63 cells. epigallocatechin gallate 9-13 C-C motif chemokine ligand 2 Homo sapiens 39-43 18821707-14 2008 EGCG alleviated the severity of CIA, probably by suppressing CCL2 synthesis in osteoblasts to diminish macrophage infiltration. epigallocatechin gallate 0-4 C-C motif chemokine ligand 2 Homo sapiens 61-65 18790652-6 2008 Accordingly, MCP-1 significantly promoted the release of RANTES from endogenous pre-made vesicles, in an active process that depended on calcium from intracellular and extracellular sources, and on intracellular transport of RANTES towards exocytosis. Calcium 137-144 C-C motif chemokine ligand 2 Homo sapiens 13-18 18937353-9 2008 CONCLUSIONS: The results of these analyses indicate that, if maternal CCL-2 genotype is related to the risk of spina bifida, this relationship is likely to be more complex than initially hypothesized, perhaps depending upon folate intake, MTHFR 677C>T genotype, the distribution of folate derivatives, and immune/inflammatory activity. Folic Acid 224-230 C-C motif chemokine ligand 2 Homo sapiens 70-75 18937353-9 2008 CONCLUSIONS: The results of these analyses indicate that, if maternal CCL-2 genotype is related to the risk of spina bifida, this relationship is likely to be more complex than initially hypothesized, perhaps depending upon folate intake, MTHFR 677C>T genotype, the distribution of folate derivatives, and immune/inflammatory activity. Folic Acid 285-291 C-C motif chemokine ligand 2 Homo sapiens 70-75 18611860-5 2008 Both cell survival and survivin expression were stunted in CCL2-stimulated PC3 cells when treated either with the phosphatidylinositol 3-kinase inhibitor LY294002 (2 microm) or the Akt-specific inhibitor-X (Akti-X; 2.5 microm). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 154-162 C-C motif chemokine ligand 2 Homo sapiens 59-63 18827968-2 2008 We investigated the ability of bindarit, an inhibitor of monocyte chemoattractant protein-1 (MCP-1/CCL2) synthesis, to inhibit chemokine production by human intestinal epithelial cells (HT-29) and its effect in trinitro-benzene sulfonic acid (TNBS)-induced colitis in mice. bindarit 31-39 C-C motif chemokine ligand 2 Homo sapiens 57-91 18827968-2 2008 We investigated the ability of bindarit, an inhibitor of monocyte chemoattractant protein-1 (MCP-1/CCL2) synthesis, to inhibit chemokine production by human intestinal epithelial cells (HT-29) and its effect in trinitro-benzene sulfonic acid (TNBS)-induced colitis in mice. bindarit 31-39 C-C motif chemokine ligand 2 Homo sapiens 93-98 18827968-2 2008 We investigated the ability of bindarit, an inhibitor of monocyte chemoattractant protein-1 (MCP-1/CCL2) synthesis, to inhibit chemokine production by human intestinal epithelial cells (HT-29) and its effect in trinitro-benzene sulfonic acid (TNBS)-induced colitis in mice. bindarit 31-39 C-C motif chemokine ligand 2 Homo sapiens 99-103 18827968-6 2008 RESULTS: In HT-29 cells, bindarit concentration-dependently and selectively inhibited MCP-1 secretion (as well as mRNA expression) primed by TNF-alpha/IFN-gamma. bindarit 25-33 C-C motif chemokine ligand 2 Homo sapiens 86-91 18611860-5 2008 Both cell survival and survivin expression were stunted in CCL2-stimulated PC3 cells when treated either with the phosphatidylinositol 3-kinase inhibitor LY294002 (2 microm) or the Akt-specific inhibitor-X (Akti-X; 2.5 microm). akti-x 207-213 C-C motif chemokine ligand 2 Homo sapiens 59-63 18611860-6 2008 Furthermore, CCL2 significantly reduced light chain 3-II (LC3-II) in serum-starved PC3; in contrast, treatment with LY294002 or Akti-X reversed the effect of CCL2 on LC3-II levels, suggesting that CCL2 signaling limits autophagy in these cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 116-124 C-C motif chemokine ligand 2 Homo sapiens 158-162 18611860-6 2008 Furthermore, CCL2 significantly reduced light chain 3-II (LC3-II) in serum-starved PC3; in contrast, treatment with LY294002 or Akti-X reversed the effect of CCL2 on LC3-II levels, suggesting that CCL2 signaling limits autophagy in these cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 116-124 C-C motif chemokine ligand 2 Homo sapiens 158-162 18611860-12 2008 Altogether, these findings indicate that CCL2 protects prostate cancer PC3 cells from autophagic death via the phosphatidylinositol 3-kinase/Akt/survivin pathway and reveal survivin as a critical molecule in this survival mechanism. Phosphatidylinositols 111-131 C-C motif chemokine ligand 2 Homo sapiens 41-45 18702954-6 2008 CCL2 was significantly higher in MC and in MC + AT than in control 1 or in control 2 (P < .01). Methylcholanthrene 33-35 C-C motif chemokine ligand 2 Homo sapiens 0-4 18579703-0 2008 MCP-1/CCR2 system is involved in high glucose-induced fibronectin and type IV collagen expression in cultured mesangial cells. Glucose 38-45 C-C motif chemokine ligand 2 Homo sapiens 0-5 18579703-3 2008 This study was undertaken to investigate the functional role of the MCP-1/CCR2 system in high glucose-induced ECM (fibronectin and type IV collagen) protein expression in cultured mesangial cells (MCs). Glucose 94-101 C-C motif chemokine ligand 2 Homo sapiens 68-73 18775807-4 2008 Here we comprehensively examine the effect of bindarit on the chemokine system, and report that in activated monocytes and endothelial cells, it selectively inhibits the production of the monocyte chemotactic protein subfamily of CC inflammatory chemokines (MCP-1/CCL2, MCP-3/CCL7, MCP-2/CCL8). bindarit 46-54 C-C motif chemokine ligand 2 Homo sapiens 258-263 18775807-4 2008 Here we comprehensively examine the effect of bindarit on the chemokine system, and report that in activated monocytes and endothelial cells, it selectively inhibits the production of the monocyte chemotactic protein subfamily of CC inflammatory chemokines (MCP-1/CCL2, MCP-3/CCL7, MCP-2/CCL8). bindarit 46-54 C-C motif chemokine ligand 2 Homo sapiens 264-268 18616672-13 2008 Consistent with inhibition of IL-6-induced STAT3 DNA binding in alcohol-pretreated cells, the levels of IL-6-dependent genes, MCP-1 and ICAM-1, was reduced after IL-6 stimulation. Alcohols 64-71 C-C motif chemokine ligand 2 Homo sapiens 126-131 18644347-5 2008 As a result, TNFalpha-induced expression of inflammatory cytokines, CXCL1/KC and CCL2/MCP-1, was clearly inhibited by Celecoxib. Celecoxib 118-127 C-C motif chemokine ligand 2 Homo sapiens 81-85 18644347-5 2008 As a result, TNFalpha-induced expression of inflammatory cytokines, CXCL1/KC and CCL2/MCP-1, was clearly inhibited by Celecoxib. Celecoxib 118-127 C-C motif chemokine ligand 2 Homo sapiens 86-91 18702954-6 2008 CCL2 was significantly higher in MC and in MC + AT than in control 1 or in control 2 (P < .01). Methylcholanthrene 43-47 C-C motif chemokine ligand 2 Homo sapiens 0-4 18702954-7 2008 A high CCL2 level (>mean + SD control 1; >730 pg/mL) was present in 2% control 1, 1% control 2, 18% MC, and 21% MC + AT (P < .0001). Methylcholanthrene 106-108 C-C motif chemokine ligand 2 Homo sapiens 7-11 18702954-7 2008 A high CCL2 level (>mean + SD control 1; >730 pg/mL) was present in 2% control 1, 1% control 2, 18% MC, and 21% MC + AT (P < .0001). Methylcholanthrene 118-122 C-C motif chemokine ligand 2 Homo sapiens 7-11 18702954-8 2008 The study demonstrates high CXCL10 and CCL2 serum levels in patients with MC; CXCL10 in MC + AT is significantly higher than that in MC. Methylcholanthrene 74-76 C-C motif chemokine ligand 2 Homo sapiens 39-43 18702954-8 2008 The study demonstrates high CXCL10 and CCL2 serum levels in patients with MC; CXCL10 in MC + AT is significantly higher than that in MC. mc + at 88-95 C-C motif chemokine ligand 2 Homo sapiens 39-43 18758143-5 2008 Consistent with previous reports, exposure of ECV304 cells to high glucose for 24 h caused an increase of intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein 1 (MCP-1), and promoted cell adhesion between monocyte and ECV304 cells. Glucose 67-74 C-C motif chemokine ligand 2 Homo sapiens 153-187 18492738-7 2008 RESULTS: The inhibition of LPS-induced interleukin (IL)1beta, IL6, IL8, monocyte chemotactic protein (MCP)-1 and macrophage inflammatory protein (MIP)-1alpha release by dexamethasone (10(-6) M) was significantly less in macrophages from patients with severe asthma than in macrophages from patients with non-severe asthma. Dexamethasone 169-182 C-C motif chemokine ligand 2 Homo sapiens 72-108 18554678-3 2008 Contact of styrene with epithelial cells stimulates the expression of a variety of inflammatory mediators, including the chemotactic cytokine monocyte chemoattractant protein-1 (MCP-1). Styrene 11-18 C-C motif chemokine ligand 2 Homo sapiens 142-176 18554678-3 2008 Contact of styrene with epithelial cells stimulates the expression of a variety of inflammatory mediators, including the chemotactic cytokine monocyte chemoattractant protein-1 (MCP-1). Styrene 11-18 C-C motif chemokine ligand 2 Homo sapiens 178-183 18554678-5 2008 The results demonstrate that styrene-induced MCP-1 expression, as well as the expression of the oxidative stress marker glutathione S-transferase (GST), is associated with a concentration dependent pattern of NF-kappaB activity. Styrene 29-36 C-C motif chemokine ligand 2 Homo sapiens 45-50 18554678-6 2008 An inhibitor of NF-kappaB, IKK-NBD, and the anti-inflammatory antioxidant N-acetylcysteine (NAC) were both effective in suppressing styrene-induced MCP-1 secretion. Acetylcysteine 74-90 C-C motif chemokine ligand 2 Homo sapiens 148-153 18554678-6 2008 An inhibitor of NF-kappaB, IKK-NBD, and the anti-inflammatory antioxidant N-acetylcysteine (NAC) were both effective in suppressing styrene-induced MCP-1 secretion. Acetylcysteine 92-95 C-C motif chemokine ligand 2 Homo sapiens 148-153 18554678-6 2008 An inhibitor of NF-kappaB, IKK-NBD, and the anti-inflammatory antioxidant N-acetylcysteine (NAC) were both effective in suppressing styrene-induced MCP-1 secretion. Styrene 132-139 C-C motif chemokine ligand 2 Homo sapiens 148-153 19967051-3 2008 The combination of cilostazol (0.3~3 microM) with probucol (0.1~0.3 microM) inhibited the expression of vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1 (MCP-1) more significantly than did the monotherapy with either probucol or cilostazol. Cilostazol 19-29 C-C motif chemokine ligand 2 Homo sapiens 151-185 18493738-9 2008 RESULTS: Physiological concentrations of C-peptide affect high glucose-induced endothelial dysfunction by: (1) decreasing VCAM-1 expression and U-937 cell adherence to HAEC; (2) reducing secretion of IL-8 and MCP-1; and (3) suppressing NF-kappaB activation. Glucose 63-70 C-C motif chemokine ligand 2 Homo sapiens 209-214 18528327-3 2008 In 54 patients with less than 20% chronic damage, there was a significant correlation between the urinary albumin to creatinine ratio and MCP-1/CCL2, and MCP-1/CCL2 and macrophages but not between MCP-1/CCL2 and capillary density. Creatinine 117-127 C-C motif chemokine ligand 2 Homo sapiens 138-143 18528327-3 2008 In 54 patients with less than 20% chronic damage, there was a significant correlation between the urinary albumin to creatinine ratio and MCP-1/CCL2, and MCP-1/CCL2 and macrophages but not between MCP-1/CCL2 and capillary density. Creatinine 117-127 C-C motif chemokine ligand 2 Homo sapiens 144-148 19967051-3 2008 The combination of cilostazol (0.3~3 microM) with probucol (0.1~0.3 microM) inhibited the expression of vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1 (MCP-1) more significantly than did the monotherapy with either probucol or cilostazol. Cilostazol 19-29 C-C motif chemokine ligand 2 Homo sapiens 187-192 19967051-3 2008 The combination of cilostazol (0.3~3 microM) with probucol (0.1~0.3 microM) inhibited the expression of vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1 (MCP-1) more significantly than did the monotherapy with either probucol or cilostazol. Probucol 50-58 C-C motif chemokine ligand 2 Homo sapiens 151-185 18469140-7 2008 It is noteworthy that CCL2 mediated extracellular signal-regulated kinase 1/2 phosphorylation and calcium mobilization was significantly enhanced by CXCL8 in monocytes, indicating cooperative downstream signaling pathways during enhanced chemotaxis. Calcium 98-105 C-C motif chemokine ligand 2 Homo sapiens 22-26 19967051-3 2008 The combination of cilostazol (0.3~3 microM) with probucol (0.1~0.3 microM) inhibited the expression of vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1 (MCP-1) more significantly than did the monotherapy with either probucol or cilostazol. Probucol 50-58 C-C motif chemokine ligand 2 Homo sapiens 187-192 18622277-9 2008 Tumor necrosis factor-alpha, interleukin-1beta, monocyte chemotactic protein-1, and macrophage inflammatory protein-1beta production from the impure sirolimus group significantly decreased (P<0.05). Sirolimus 149-158 C-C motif chemokine ligand 2 Homo sapiens 48-78 18645721-5 2008 Exposure of lung epithelial cells to chlorobenzene resulted in an activation of NF-kappa B and p38 MAP kinase and a release of the chemokine MCP-1. chlorobenzene 37-50 C-C motif chemokine ligand 2 Homo sapiens 141-146 18645721-7 2008 Our data show that the release of MCP-1 following chlorobenzene exposure is dependent on the NF-kappa B and MAPK pathways. chlorobenzene 50-63 C-C motif chemokine ligand 2 Homo sapiens 34-39 21479441-4 2008 EGCG downregulated the levels of pro-inflammatory cytokine interleukin (IL)-6 and chemokines IL-8, monocyte-chemoattractant protein (MCP)-1 and RANTES. epigallocatechin gallate 0-4 C-C motif chemokine ligand 2 Homo sapiens 99-139 18239617-5 2008 Functionally, histamine and H(4)R agonists clobenpropit and 4-methylhistamine downregulated the production of the Th2-linked chemokine CCL2 and the Th1 cytokine IL-12 on Mo-IDEC, whereas agonists for the other histamine receptors did not. Histamine 14-23 C-C motif chemokine ligand 2 Homo sapiens 135-139 18239617-5 2008 Functionally, histamine and H(4)R agonists clobenpropit and 4-methylhistamine downregulated the production of the Th2-linked chemokine CCL2 and the Th1 cytokine IL-12 on Mo-IDEC, whereas agonists for the other histamine receptors did not. clobenpropit 43-55 C-C motif chemokine ligand 2 Homo sapiens 135-139 18239617-5 2008 Functionally, histamine and H(4)R agonists clobenpropit and 4-methylhistamine downregulated the production of the Th2-linked chemokine CCL2 and the Th1 cytokine IL-12 on Mo-IDEC, whereas agonists for the other histamine receptors did not. 4-methylhistamine 60-77 C-C motif chemokine ligand 2 Homo sapiens 135-139 18676106-10 2008 MCP-1 concentrations in the supernatants of oxLDL-stimulated HUVEC cultures were inhibited by 7.5 microM beta-sitosterol as well as by progesterone and the mixture of the two female hormones. gamma-sitosterol 105-120 C-C motif chemokine ligand 2 Homo sapiens 0-5 18676106-10 2008 MCP-1 concentrations in the supernatants of oxLDL-stimulated HUVEC cultures were inhibited by 7.5 microM beta-sitosterol as well as by progesterone and the mixture of the two female hormones. Progesterone 135-147 C-C motif chemokine ligand 2 Homo sapiens 0-5 18799820-8 2008 Perindopril significantly reduced plasma levels of oxidized LDLs, CRP, MCP-1, fibrinogen and PAI-1, and increased interleukin-10. Perindopril 0-11 C-C motif chemokine ligand 2 Homo sapiens 71-76 18563354-7 2008 The reduced adhesion by EPS was correlated with suppressed expression of MCP-1 and IL-8, the major chemokines in IBD. eps 24-27 C-C motif chemokine ligand 2 Homo sapiens 73-78 18705004-0 2008 [Effect of Cryptoporus polysaccharide on lipopolysaccharide-induced production of monocyte chemoattractant protein-1 in human alveolar epithelial cells]. cryptoporus polysaccharide 11-37 C-C motif chemokine ligand 2 Homo sapiens 82-116 18705004-4 2008 RESULT: The protein concentration of MCP-1 was significantly increased by LPS 1000 microg/L at 24 h. There were no effects on the growth and viability of A549 cells in the presence of CP 100 microg/L or dexamethasone 1 mumol/L. Dexamethasone 203-216 C-C motif chemokine ligand 2 Homo sapiens 37-42 18705004-5 2008 However, CP 100 microg/L or dexamethasone 1 micromol/L significantly inhibited the protein concentration and mRNA expression of MCP-1 induced by LPS. Dexamethasone 28-41 C-C motif chemokine ligand 2 Homo sapiens 128-133 19034703-0 2008 Berberine inhibits the expression of TNFalpha, MCP-1, and IL-6 in AcLDL-stimulated macrophages through PPARgamma pathway. Berberine 0-9 C-C motif chemokine ligand 2 Homo sapiens 47-52 19034703-7 2008 The results of RT-PCR and ELISA shows that berberine may inhibit the expression and secretion of the tumor necrosis factor alpha (TNFalpha), monocyte chemoattractant protein 1 (MCP-1), and interleukin-6 (IL-6) in macrophages stimulated by acetylated low-density lipoprotein (AcLDL), whereas the peroxisome proliferator-activated receptor gamma (PPARgamma) inhibitor GW9662 could attenuate this effect of berberine. Berberine 43-52 C-C motif chemokine ligand 2 Homo sapiens 141-175 19034703-8 2008 This study demonstrates that berberine may inhibit the expression and production of TNF-alpha, MCP-1, and IL-6 in AcLDL-stimulated macrophages. Berberine 29-38 C-C motif chemokine ligand 2 Homo sapiens 95-100 19034703-7 2008 The results of RT-PCR and ELISA shows that berberine may inhibit the expression and secretion of the tumor necrosis factor alpha (TNFalpha), monocyte chemoattractant protein 1 (MCP-1), and interleukin-6 (IL-6) in macrophages stimulated by acetylated low-density lipoprotein (AcLDL), whereas the peroxisome proliferator-activated receptor gamma (PPARgamma) inhibitor GW9662 could attenuate this effect of berberine. Berberine 43-52 C-C motif chemokine ligand 2 Homo sapiens 177-182 18271757-0 2008 Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2, but not STAT3, activation. Alprostadil 0-16 C-C motif chemokine ligand 2 Homo sapiens 39-44 17869082-4 2008 Similar results were also found in cultured 3T3-L1 adipocytes; in addition, calcitriol also up-regulated macrophage colony-stimulating factor, macrophage inflammatory protein, interleukin-6 (IL-6) as well as monocyte chemoattractant protein-1 expression in 3T3-L1 adipocytes and stimulated tumor necrosis factor as well as IL-6 expression in RAW 264 macrophages. Calcitriol 76-86 C-C motif chemokine ligand 2 Homo sapiens 208-242 18271757-7 2008 In the present study, we have investigated the inhibitory activity of PGE(1) (prostaglandin E(1)) on IL-6-induced MCP-1 expression and have elucidated the underlying molecular mechanism. Alprostadil 70-76 C-C motif chemokine ligand 2 Homo sapiens 114-119 18271757-7 2008 In the present study, we have investigated the inhibitory activity of PGE(1) (prostaglandin E(1)) on IL-6-induced MCP-1 expression and have elucidated the underlying molecular mechanism. Alprostadil 78-96 C-C motif chemokine ligand 2 Homo sapiens 114-119 18291098-0 2008 Anti-inflammatory effect of resveratrol on TNF-alpha-induced MCP-1 expression in adipocytes. Resveratrol 28-39 C-C motif chemokine ligand 2 Homo sapiens 61-66 18473409-12 2008 CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. Mesalamine 47-57 C-C motif chemokine ligand 2 Homo sapiens 175-180 18291098-3 2008 In this study we investigated the effects of resveratrol upon both tumor necrosis factor (TNF)-alpha-induced MCP-1 gene expression and its underlying signaling pathways in 3T3-L1 adipocytes. Resveratrol 45-56 C-C motif chemokine ligand 2 Homo sapiens 109-114 18267111-4 2008 DAA significantly suppressed the production of proinflammatory mediators such as MCP-1, TNF-alpha, and NO in stimulated RAW 264 macrophages and in the coculture of RAW 264 macrophages and 3T3-L1 adipocytes. dehydroabietic acid 0-3 C-C motif chemokine ligand 2 Homo sapiens 81-86 18291098-4 2008 Resveratrol was found to inhibit TNF-alpha-induced MCP-1 secretion and gene transcription, as well as promoter activity, which based on down-regulation of TNF-alpha-induced MCP-1 transcription. Resveratrol 0-11 C-C motif chemokine ligand 2 Homo sapiens 51-56 18291098-4 2008 Resveratrol was found to inhibit TNF-alpha-induced MCP-1 secretion and gene transcription, as well as promoter activity, which based on down-regulation of TNF-alpha-induced MCP-1 transcription. Resveratrol 0-11 C-C motif chemokine ligand 2 Homo sapiens 173-178 18291098-7 2008 Finally, the inhibition of MCP-1 may represent a novel mechanism of resveratrol in preventing obesity-related pathologies. Resveratrol 68-79 C-C motif chemokine ligand 2 Homo sapiens 27-32 18216048-2 2008 The current study investigated the role of monocyte chemotactic protein (MCP)-1 in the chemotactic transmigration of ATRA-treated NB4 (ATRA-NB4) APL cells toward A549 alveolar epithelial cells. Tretinoin 117-121 C-C motif chemokine ligand 2 Homo sapiens 43-79 18322021-6 2008 In cultured primary human renal mesangial cells (HMC), the high-glucose medium-induced upregulation of VEGF and MCP-1 was largely blocked by PEDF. Glucose 64-71 C-C motif chemokine ligand 2 Homo sapiens 112-117 18216048-6 2008 The secretion of MCP-1 was enhanced by ATRA treatment in both A549 and NB4 cells. Tretinoin 39-43 C-C motif chemokine ligand 2 Homo sapiens 17-22 18216048-10 2008 Monocyte chemotactic protein-1 secreted from alveolar epithelial cells plays an important role in the cell-cell interaction involved in the chemotactic transmigration of all-trans retinoic acid-treated acute promyelocytic leukaemia cells toward alveolar epithelial cells. Tretinoin 180-193 C-C motif chemokine ligand 2 Homo sapiens 0-30 18203956-0 2008 Phosphatidylcholine-specific phospholipase C activation is required for CCR5-dependent, NF-kB-driven CCL2 secretion elicited in response to HIV-1 gp120 in human primary macrophages. Phosphatidylcholines 0-19 C-C motif chemokine ligand 2 Homo sapiens 101-105 18080321-3 2008 Our experiments showed that protein production and mRNA expressions of MMP-1, MMP-3, MMP-13, IL-8, MCP-1, and RANTES were downregulated by treatment with glucosamine in HPSFs. Glucosamine 154-165 C-C motif chemokine ligand 2 Homo sapiens 99-104 18080321-6 2008 The results suggest that the inhibition of MMP-1, -3, and -13 expressions as well as IL-8, MCP-1, and RANTES productions by GLN might mediate suppression of NF-kappaB signal pathways, and HPSFs seem to have a potential functions as an alternative source of MMPs and chemokines for inducing the degradation of cartilage in OA. Glucosamine 124-127 C-C motif chemokine ligand 2 Homo sapiens 91-96 18347511-8 2008 CONCLUSION: An increase in adiponectin level due to a decrease in estradiol results in a reduction in monocyte chemotactic protein-1 level in postmenopausal women, suggesting that adiponectin may be associated with a protective role against insulin resistance and atherosclerosis, which occur in the postmenopausal stage. Estradiol 66-75 C-C motif chemokine ligand 2 Homo sapiens 102-132 18353310-5 2008 The topical application of a low dose (10 pg, 1 ng, or 100 ng/wound area) of asiaticoside increased monocyte chemoattractant protein-1 (MCP-1), vascular endothelial growth factor (VEGF), and interleukin (IL)-1beta levels in burn wound exudates. asiaticoside 77-89 C-C motif chemokine ligand 2 Homo sapiens 100-134 18353310-5 2008 The topical application of a low dose (10 pg, 1 ng, or 100 ng/wound area) of asiaticoside increased monocyte chemoattractant protein-1 (MCP-1), vascular endothelial growth factor (VEGF), and interleukin (IL)-1beta levels in burn wound exudates. asiaticoside 77-89 C-C motif chemokine ligand 2 Homo sapiens 136-141 18353310-7 2008 Furthermore, asiaticoside (10 pg to 100 ng/ml) increased the IL-1beta production in THP-1 macrophages with MCP-1, but it had no effect on IL-1beta production without MCP-1 or with lipopolysaccharide (LPS). asiaticoside 13-25 C-C motif chemokine ligand 2 Homo sapiens 107-112 18353310-8 2008 These findings suggest that the enhancement of burn wound healing by asiaticoside might be due to the promotion of angiogenesis during skin wound repair as a result of the stimulation of VEGF production caused by the increase in MCP-1 expression in keratinocytes and the increase in IL-1beta expression in macrophages induced cooperatively by asiaticoside plus MCP-1. asiaticoside 69-81 C-C motif chemokine ligand 2 Homo sapiens 229-234 18353310-8 2008 These findings suggest that the enhancement of burn wound healing by asiaticoside might be due to the promotion of angiogenesis during skin wound repair as a result of the stimulation of VEGF production caused by the increase in MCP-1 expression in keratinocytes and the increase in IL-1beta expression in macrophages induced cooperatively by asiaticoside plus MCP-1. asiaticoside 69-81 C-C motif chemokine ligand 2 Homo sapiens 361-366 18242157-11 2008 15d-PGJ2 and ciglitazone blocked the induction of MCP-1 by TNF-alpha. 15-deoxy-delta(12,14)-prostaglandin J2 0-8 C-C motif chemokine ligand 2 Homo sapiens 50-55 18242157-11 2008 15d-PGJ2 and ciglitazone blocked the induction of MCP-1 by TNF-alpha. ciglitazone 13-24 C-C motif chemokine ligand 2 Homo sapiens 50-55 18242157-12 2008 Moreover, the addition of MCP-1 rescued the inhibition of TRAP-positive multinucleated cell (TRAP-MNCs) formation by 15d-PGJ2 and ciglitazone, although generated TRAP-MNCs had no capacity to resorb dentin slices. 15-deoxy-delta(12,14)-prostaglandin J2 117-125 C-C motif chemokine ligand 2 Homo sapiens 26-31 18393413-1 2008 We report the first measured activation parameters for the additions of CCl2 and CClF to simple alkenes and demonstrate the existence of enthalpic barriers for CCl2 additions to cyclohexene and 1-hexene. CClF 81-85 C-C motif chemokine ligand 2 Homo sapiens 160-164 18393413-1 2008 We report the first measured activation parameters for the additions of CCl2 and CClF to simple alkenes and demonstrate the existence of enthalpic barriers for CCl2 additions to cyclohexene and 1-hexene. Alkenes 96-103 C-C motif chemokine ligand 2 Homo sapiens 72-76 18393413-1 2008 We report the first measured activation parameters for the additions of CCl2 and CClF to simple alkenes and demonstrate the existence of enthalpic barriers for CCl2 additions to cyclohexene and 1-hexene. cyclohexene 178-189 C-C motif chemokine ligand 2 Homo sapiens 72-76 18393413-1 2008 We report the first measured activation parameters for the additions of CCl2 and CClF to simple alkenes and demonstrate the existence of enthalpic barriers for CCl2 additions to cyclohexene and 1-hexene. cyclohexene 178-189 C-C motif chemokine ligand 2 Homo sapiens 160-164 18393413-1 2008 We report the first measured activation parameters for the additions of CCl2 and CClF to simple alkenes and demonstrate the existence of enthalpic barriers for CCl2 additions to cyclohexene and 1-hexene. 1-hexene 194-202 C-C motif chemokine ligand 2 Homo sapiens 72-76 18393413-1 2008 We report the first measured activation parameters for the additions of CCl2 and CClF to simple alkenes and demonstrate the existence of enthalpic barriers for CCl2 additions to cyclohexene and 1-hexene. 1-hexene 194-202 C-C motif chemokine ligand 2 Homo sapiens 160-164 18242157-12 2008 Moreover, the addition of MCP-1 rescued the inhibition of TRAP-positive multinucleated cell (TRAP-MNCs) formation by 15d-PGJ2 and ciglitazone, although generated TRAP-MNCs had no capacity to resorb dentin slices. ciglitazone 130-141 C-C motif chemokine ligand 2 Homo sapiens 26-31 18242157-13 2008 Our data demonstrate that 15d-PGJ2 and ciglitazone down-regulate TNF-alpha-mediated osteoclast differentiation in human cells, in part via suppression of the action of MCP-1. 15-deoxy-delta(12,14)-prostaglandin J2 26-34 C-C motif chemokine ligand 2 Homo sapiens 168-173 18203956-3 2008 In this study, we show for the first time that the phosphatidylcholine-specific phospholipase C (PC-PLC) is required for the production of CCL2 triggered by gp120 in human monocyte-derived macrophages (MDMs). Phosphatidylcholines 51-70 C-C motif chemokine ligand 2 Homo sapiens 139-143 18242157-13 2008 Our data demonstrate that 15d-PGJ2 and ciglitazone down-regulate TNF-alpha-mediated osteoclast differentiation in human cells, in part via suppression of the action of MCP-1. ciglitazone 39-50 C-C motif chemokine ligand 2 Homo sapiens 168-173 18264128-6 2008 MCP-1 mRNA expression and NF-kappaB activity were enhanced by venom sPLA2-treated LDL, which was completely suppressed by indoxam but not by thioetheramide-PC, a competitive sPLA2 inhibitor. indoxam 122-129 C-C motif chemokine ligand 2 Homo sapiens 0-5 17925051-8 2008 TFA treatment also induced the release of monocyte chemoattractant protein-1 by nearly 3-fold in non-stimulated HAEC. Trifluoroacetic Acid 0-3 C-C motif chemokine ligand 2 Homo sapiens 42-76 18264128-10 2008 Indoxam suppressed MCP-1 mRNA expression and NF-kappaB activity in TNFalpha-stimulated HUVEC incubated with native or glycoxidized LDL. indoxam 0-7 C-C motif chemokine ligand 2 Homo sapiens 19-24 18190912-14 2008 These data suggest that the enhanced expression of MCP-1 and microglia activities in alcoholic brains could contribute to ethanol-induced pathogenesis. Ethanol 122-129 C-C motif chemokine ligand 2 Homo sapiens 51-56 18192240-5 2008 Simvastatin treatment lead to downregulation of many pro-inflammatory genes including several chemokines [e.g. monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory proteins-1alpha and beta, interleukin-2 receptor-beta], members of the tumour necrosis factor family (e.g. lymphotoxin beta), vascular cell adhesion molecule-1, and tissue factor (TF). Simvastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 111-141 18192240-5 2008 Simvastatin treatment lead to downregulation of many pro-inflammatory genes including several chemokines [e.g. monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory proteins-1alpha and beta, interleukin-2 receptor-beta], members of the tumour necrosis factor family (e.g. lymphotoxin beta), vascular cell adhesion molecule-1, and tissue factor (TF). Simvastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 143-148 18192240-7 2008 The effects of simvastatin on MCP-1 and TF could be mimicked by KLF-2 overexpression using lentiviral gene transfer. Simvastatin 15-26 C-C motif chemokine ligand 2 Homo sapiens 30-35 18178718-3 2008 Human monocytes treated with the CB2 agonist JWH-015 for 12-18 h showed significantly reduced migration to chemokines CCL2 and CCL3, associated with reduced mRNA and surface expression of their receptors CCR2 and CCR1. JHW 015 45-52 C-C motif chemokine ligand 2 Homo sapiens 118-122 18282229-3 2008 Exogenous administration of C-C chemokines, particularly monocyte chemoattractant protein (MCP)-1, led to the induction of superoxide anion generation via the restoration of impaired protein kinase C (PKC) signalling in Man-LAM-treated macrophages. Superoxides 123-139 C-C motif chemokine ligand 2 Homo sapiens 57-97 18282229-3 2008 Exogenous administration of C-C chemokines, particularly monocyte chemoattractant protein (MCP)-1, led to the induction of superoxide anion generation via the restoration of impaired protein kinase C (PKC) signalling in Man-LAM-treated macrophages. lipoarabinomannan 224-227 C-C motif chemokine ligand 2 Homo sapiens 57-97 17467819-8 2008 In the culture supernatants, MCP-1 concentrations were reduced by nebivolol. Nebivolol 66-75 C-C motif chemokine ligand 2 Homo sapiens 29-34 20641934-12 2004 (12) successfully labeled recombinant human MCP-1 with (99m)Tc using the nicotinic acid analog hydrazinonicotinamide (HYNIC) as the chelator. Technetium 60-62 C-C motif chemokine ligand 2 Homo sapiens 44-49 20641934-12 2004 (12) successfully labeled recombinant human MCP-1 with (99m)Tc using the nicotinic acid analog hydrazinonicotinamide (HYNIC) as the chelator. Niacin 73-87 C-C motif chemokine ligand 2 Homo sapiens 44-49 20641934-12 2004 (12) successfully labeled recombinant human MCP-1 with (99m)Tc using the nicotinic acid analog hydrazinonicotinamide (HYNIC) as the chelator. hydrazino nicotinamide 95-116 C-C motif chemokine ligand 2 Homo sapiens 44-49 18206870-7 2008 Pretreatment of AM with INO-1001 decreased both the early translocation of NFkappaB and the production of TNF-alpha (p<0.05) and MIP-1alpha p=0.02, but did not affect CINC or MCP-1 production. INO 1001 24-32 C-C motif chemokine ligand 2 Homo sapiens 178-183 18379402-0 2008 1,25(OH)2-vitamin D3 inhibits proliferation and decreases production of monocyte chemoattractant protein-1, thrombopoietin, VEGF, and angiogenin by human annulus cells in vitro. Calcitriol 0-20 C-C motif chemokine ligand 2 Homo sapiens 72-106 17880982-7 2008 Quercetin also inhibited MCP-1 gene expression. Quercetin 0-9 C-C motif chemokine ligand 2 Homo sapiens 25-30 18398813-7 2008 Intake of ethanol or de-alcoholised red wine significantly reduced monocyte chemoattractant protein-1 (MCP-1)-induced monocyte migration by 58% (p<0.05; n=6) and 36% (p<0.05; n=7) and FMLP (N-formyl-methionyl-leucyl-phenylalanine)-induced migration by 41% (p<0.05) and 36% (p<0.05), respectively. Ethanol 10-17 C-C motif chemokine ligand 2 Homo sapiens 67-101 17588584-6 2008 At the end of the study, these parameters were significantly lower in the pioglitazone group as compared to the placebo group (MMP-9: 392+/-286 versus 427+/-166 ng/ml; hsCRP: 1.9+/-1.7 versus 3.1+/-2.3 ng/L; MCP-1: 413+/-115 versus 471+/-146 pg/ml; p<0.05, respectively). Pioglitazone 74-86 C-C motif chemokine ligand 2 Homo sapiens 208-213 18235151-0 2008 Reduced albuminuria with sarpogrelate is accompanied by a decrease in monocyte chemoattractant protein-1 levels in type 2 diabetes. sarpogrelate 25-37 C-C motif chemokine ligand 2 Homo sapiens 70-104 18235151-6 2008 Moreover, percentage change of monocyte chemoattractant protein-1 level correlated positively to that of albumin-to-creatinine ratio. Creatinine 116-126 C-C motif chemokine ligand 2 Homo sapiens 31-65 18226915-5 2008 All chemokines except RANTES were significantly high in PF compared to BL in TB group, whereas IL-8 and MCP-1 showed significant increase only in NTB PF. ntb pf 146-152 C-C motif chemokine ligand 2 Homo sapiens 104-109 18398813-7 2008 Intake of ethanol or de-alcoholised red wine significantly reduced monocyte chemoattractant protein-1 (MCP-1)-induced monocyte migration by 58% (p<0.05; n=6) and 36% (p<0.05; n=7) and FMLP (N-formyl-methionyl-leucyl-phenylalanine)-induced migration by 41% (p<0.05) and 36% (p<0.05), respectively. Ethanol 10-17 C-C motif chemokine ligand 2 Homo sapiens 103-108 17399814-0 2008 Simvastatin exerts its anti-inflammatory effect in hypercholesterolaemic patients by decreasing the serum levels of monocyte chemoattractant protein-1. Simvastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 116-150 18286574-5 2008 Constitutive signaling was shown using inositol phosphate assays and inducible calcium signaling by response to CCL2, CCL5 and CCL11. Calcium 79-86 C-C motif chemokine ligand 2 Homo sapiens 112-116 18046654-0 2008 Cocaine-mediated alteration in tight junction protein expression and modulation of CCL2/CCR2 axis across the blood-brain barrier: implications for HIV-dementia. Cocaine 0-7 C-C motif chemokine ligand 2 Homo sapiens 83-87 18046654-6 2008 Furthermore, cocaine also modulated upregulation of the CCL2/CCR2 axis in monocytes. Cocaine 13-20 C-C motif chemokine ligand 2 Homo sapiens 56-60 17399814-4 2008 RESULTS: From the inflammatory markers only MCP-1 was decreased significantly (217.4+/-48 versus 177+/-75 pg/ml, p<0.001) after treatment with simvastatin and this reduction was independent of lipid changes. Simvastatin 146-157 C-C motif chemokine ligand 2 Homo sapiens 44-49 17399814-5 2008 CONCLUSION: Simvastatin significantly decreases only MCP-1 levels in hypercholesterolaemic patients suggesting that this molecule is probably a sensitive marker to detect the anti-inflammatory effect of simvastatin in blood. Simvastatin 12-23 C-C motif chemokine ligand 2 Homo sapiens 53-58 17399814-5 2008 CONCLUSION: Simvastatin significantly decreases only MCP-1 levels in hypercholesterolaemic patients suggesting that this molecule is probably a sensitive marker to detect the anti-inflammatory effect of simvastatin in blood. Simvastatin 203-214 C-C motif chemokine ligand 2 Homo sapiens 53-58 18089573-0 2008 Monocyte chemoattractant protein-1 expression is enhanced by granulocyte-macrophage colony-stimulating factor via Jak2-Stat5 signaling and inhibited by atorvastatin in human monocytic U937 cells. Atorvastatin 152-164 C-C motif chemokine ligand 2 Homo sapiens 0-34 18089573-7 2008 This GM-CSF-induced MCP-1 expression, measured as both protein and mRNA levels, was down-regulated by atorvastatin, a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor. Atorvastatin 102-114 C-C motif chemokine ligand 2 Homo sapiens 20-25 17977946-2 2008 The present study aimed to clarify changes in population dynamics of intestinal muscularis macrophages during colonic inflammation and to test possible inhibitory actions of agents targeting monocyte chemoattractant protein-1 (MCP-1) on muscularis macrophage dynamics and motility disorder in the colonic inflammation elicited by 2,4,6-trinitrobenzene sulfonic acid. Trinitrobenzenesulfonic Acid 330-365 C-C motif chemokine ligand 2 Homo sapiens 227-232 18283585-6 2008 RESULTS: We found that pretreatment with cerivastatin significantly abrogates the production of inflammatory cytokines TNF-alpha and MCP-1 by human monocytes in response to polymethylmethacrylate particle activation. cerivastatin 41-53 C-C motif chemokine ligand 2 Homo sapiens 133-138 18283585-6 2008 RESULTS: We found that pretreatment with cerivastatin significantly abrogates the production of inflammatory cytokines TNF-alpha and MCP-1 by human monocytes in response to polymethylmethacrylate particle activation. Polymethyl Methacrylate 173-195 C-C motif chemokine ligand 2 Homo sapiens 133-138 18060855-0 2008 Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes. aurapten 7-16 C-C motif chemokine ligand 2 Homo sapiens 86-91 18060855-6 2008 The results indicate that auraptene activates PPARgamma in adipocytes to control adipocytekines such as adiponectin and MCP-1 and suggest that the consumption of citrus fruits, which contain auraptene can lead to a partial prevention of lipid and glucose metabolism abnormalities. aurapten 26-35 C-C motif chemokine ligand 2 Homo sapiens 120-125 18060855-4 2008 In contrast, auraptene suppressed monocyte chemoattractant protein (MCP)-1 expression in 3T3-L1 adipocytes. aurapten 13-22 C-C motif chemokine ligand 2 Homo sapiens 34-74 17943082-7 2008 The area of the EGF/MCP-1 ratio was significantly higher than that of EGF or MCP-1 alone, histologic grade, creatinine clearance, or proteinuria. Creatinine 108-118 C-C motif chemokine ligand 2 Homo sapiens 20-25 18055523-8 2008 CT-1-mediated upregulation of ICAM-1 and MCP-1 was suppressed by PD-98059, SB-203580, LY-294002, and parthenolide. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 65-73 C-C motif chemokine ligand 2 Homo sapiens 41-46 18055523-8 2008 CT-1-mediated upregulation of ICAM-1 and MCP-1 was suppressed by PD-98059, SB-203580, LY-294002, and parthenolide. Antimony 75-77 C-C motif chemokine ligand 2 Homo sapiens 41-46 18055523-8 2008 CT-1-mediated upregulation of ICAM-1 and MCP-1 was suppressed by PD-98059, SB-203580, LY-294002, and parthenolide. Lysine 86-88 C-C motif chemokine ligand 2 Homo sapiens 41-46 18055523-8 2008 CT-1-mediated upregulation of ICAM-1 and MCP-1 was suppressed by PD-98059, SB-203580, LY-294002, and parthenolide. parthenolide 101-113 C-C motif chemokine ligand 2 Homo sapiens 41-46 18175929-3 2008 TNFalpha treatment of HC11 cells also induced expression of SAA genes, and the effect on SAA1 and SAA2 expression was suppressed by treatment with MG132, and in cells transfected with a dominant negative mutant form of IkappaBalpha. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 147-152 C-C motif chemokine ligand 2 Homo sapiens 22-26 18093816-10 2008 RS-102895, a CCR2-specific antagonist, significantly reduced VEGF production in CD40L- and MCP-1-stimulated HUVECs. RS 102895 0-9 C-C motif chemokine ligand 2 Homo sapiens 91-96 17604287-7 2008 Elevation of CCL2 serum levels in the lcSSc subset was not associated with pulmonary arterial hypertension, although there was a trend for reduction following treatment with prostacyclin analogues or bosentan. Epoprostenol 174-186 C-C motif chemokine ligand 2 Homo sapiens 13-17 17604287-7 2008 Elevation of CCL2 serum levels in the lcSSc subset was not associated with pulmonary arterial hypertension, although there was a trend for reduction following treatment with prostacyclin analogues or bosentan. Bosentan 200-208 C-C motif chemokine ligand 2 Homo sapiens 13-17 18161950-8 2008 Reduced catalysis with bulky halo-containing substrates is manifested in the fidelity of T-G incorporation, where the CCl2-bridging analogue shows a 27-fold increase in fidelity over the natural dGTP. deoxyguanosine triphosphate 195-199 C-C motif chemokine ligand 2 Homo sapiens 118-122 18082489-7 2008 However, from baseline to 3 months the levels of tumor necrosis factor alpha and monocyte chemoattractant protein 1 increased less in the mBMC group (P < .05 for both). mbmc 138-142 C-C motif chemokine ligand 2 Homo sapiens 81-115 18296319-9 2008 We showed that various dietary terpenoids and other natural ingredients regulate the transcription of PPAR target genes, induces the expression and secretion of adiponectin, and inhibits those of MCP-1 in adipocytes and beta-oxidation in liver. Terpenes 31-41 C-C motif chemokine ligand 2 Homo sapiens 196-201 17939949-0 2008 Toll-like receptor 9-stimulated monocyte chemoattractant protein-1 is mediated via JNK-cytosolic phospholipase A2-ROS signaling. Reactive Oxygen Species 114-117 C-C motif chemokine ligand 2 Homo sapiens 32-66 17522861-6 2008 However, only CCL2 was detected by enzyme-linked immunosorbent assay, indicating that CCL2 may be the principal chemokine for Treg migration in GBM patients. treg 126-130 C-C motif chemokine ligand 2 Homo sapiens 86-90 17522861-9 2008 Production of CCL2 by glioma cells could also be mitigated by the chemotherapeutic agents temozolomide and carmustine [3-bis (2-chloroethyl)-1-nitrosourea]. Temozolomide 90-102 C-C motif chemokine ligand 2 Homo sapiens 14-18 17522861-9 2008 Production of CCL2 by glioma cells could also be mitigated by the chemotherapeutic agents temozolomide and carmustine [3-bis (2-chloroethyl)-1-nitrosourea]. Carmustine 107-117 C-C motif chemokine ligand 2 Homo sapiens 14-18 17522861-9 2008 Production of CCL2 by glioma cells could also be mitigated by the chemotherapeutic agents temozolomide and carmustine [3-bis (2-chloroethyl)-1-nitrosourea]. 3-bis (2-chloroethyl)-1-nitrosourea 119-154 C-C motif chemokine ligand 2 Homo sapiens 14-18 17939949-2 2008 This study highlights the importance of cytosolic phospholipase A2 (cPLA2)-mediated reactive oxygen species (ROS) signaling processes in the regulation of MCP-1 release as a result of toll-like receptor (TLR) activation. Reactive Oxygen Species 84-107 C-C motif chemokine ligand 2 Homo sapiens 155-160 17939949-2 2008 This study highlights the importance of cytosolic phospholipase A2 (cPLA2)-mediated reactive oxygen species (ROS) signaling processes in the regulation of MCP-1 release as a result of toll-like receptor (TLR) activation. Reactive Oxygen Species 109-112 C-C motif chemokine ligand 2 Homo sapiens 155-160 18656701-7 2008 Selective inhibitors of p38 MAPK (SB203580), JNK (SP600125) and ERK (PD98059) could suppress TNF-alpha-induced CCL2 and ICAM-1 expression, while only p38 MAPK and ERK inhibitors could suppress TNF-alpha-induced VCAM-1 expression. SB 203580 34-42 C-C motif chemokine ligand 2 Homo sapiens 111-115 17939949-8 2008 Overall, these results suggest that CpG enhances ROS generation through cPLA2-dependent pathways, which results in MCP-1 release. Reactive Oxygen Species 49-52 C-C motif chemokine ligand 2 Homo sapiens 115-120 19364068-9 2008 Decreased MCP-1, IL-6, and IL-8 expression indicated that APS-purified islets were possibly exposed to less proinflammatory stress. aps 58-61 C-C motif chemokine ligand 2 Homo sapiens 10-15 18395486-7 2008 Furthermore, in vivo, neutralization of both JE and MCP5, the two functional orthologs of CCL2, during bleomycin-induced pulmonary fibrosis significantly reduced collagen deposition as well as JE and CCR2 expression. Bleomycin 103-112 C-C motif chemokine ligand 2 Homo sapiens 90-94 18175998-8 2008 CONCLUSIONS: These data suggest that reduction in MCP-1 production by SES may be one mechanism to prevent restenosis after coronary stenting. ses 70-73 C-C motif chemokine ligand 2 Homo sapiens 50-55 17516547-5 2008 In monocytic THP-1 cells, cilostazol and N6,O2"-dibutyryl-cAMP (dioctanoyl-cAMP, a cAMP analog) dose-dependently inhibited LPS-induced MCP-1 protein expression and MMP-9 activation, but did not affect the tissue inhibitor of metalloproteinase-1. Cilostazol 26-36 C-C motif chemokine ligand 2 Homo sapiens 135-140 17516547-5 2008 In monocytic THP-1 cells, cilostazol and N6,O2"-dibutyryl-cAMP (dioctanoyl-cAMP, a cAMP analog) dose-dependently inhibited LPS-induced MCP-1 protein expression and MMP-9 activation, but did not affect the tissue inhibitor of metalloproteinase-1. Bucladesine 41-62 C-C motif chemokine ligand 2 Homo sapiens 135-140 17516547-5 2008 In monocytic THP-1 cells, cilostazol and N6,O2"-dibutyryl-cAMP (dioctanoyl-cAMP, a cAMP analog) dose-dependently inhibited LPS-induced MCP-1 protein expression and MMP-9 activation, but did not affect the tissue inhibitor of metalloproteinase-1. N(6),O(2)-dioctanoyl cyclic AMP 64-79 C-C motif chemokine ligand 2 Homo sapiens 135-140 17516547-5 2008 In monocytic THP-1 cells, cilostazol and N6,O2"-dibutyryl-cAMP (dioctanoyl-cAMP, a cAMP analog) dose-dependently inhibited LPS-induced MCP-1 protein expression and MMP-9 activation, but did not affect the tissue inhibitor of metalloproteinase-1. Cyclic AMP 58-62 C-C motif chemokine ligand 2 Homo sapiens 135-140 17591667-0 2008 Aqueous humor levels of asymmetric dimethylarginine (ADMA) are positively associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis. dimethylarginine 35-51 C-C motif chemokine ligand 2 Homo sapiens 90-124 17591667-0 2008 Aqueous humor levels of asymmetric dimethylarginine (ADMA) are positively associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis. dimethylarginine 35-51 C-C motif chemokine ligand 2 Homo sapiens 126-131 17591667-0 2008 Aqueous humor levels of asymmetric dimethylarginine (ADMA) are positively associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis. N,N-dimethylarginine 53-57 C-C motif chemokine ligand 2 Homo sapiens 90-124 17591667-0 2008 Aqueous humor levels of asymmetric dimethylarginine (ADMA) are positively associated with monocyte chemoattractant protein-1 (MCP-1) in patients with uveitis. N,N-dimethylarginine 53-57 C-C motif chemokine ligand 2 Homo sapiens 126-131 17591667-1 2008 BACKGROUND/AIMS: The aim of the study was to evaluate whether aqueous humor levels of asymmetric dimethylarginine (ADMA) are associated with monocyte chemoattractant protein-1 (MCP-1). dimethylarginine 97-113 C-C motif chemokine ligand 2 Homo sapiens 141-175 17591667-1 2008 BACKGROUND/AIMS: The aim of the study was to evaluate whether aqueous humor levels of asymmetric dimethylarginine (ADMA) are associated with monocyte chemoattractant protein-1 (MCP-1). dimethylarginine 97-113 C-C motif chemokine ligand 2 Homo sapiens 177-182 17591667-1 2008 BACKGROUND/AIMS: The aim of the study was to evaluate whether aqueous humor levels of asymmetric dimethylarginine (ADMA) are associated with monocyte chemoattractant protein-1 (MCP-1). N,N-dimethylarginine 115-119 C-C motif chemokine ligand 2 Homo sapiens 141-175 17591667-1 2008 BACKGROUND/AIMS: The aim of the study was to evaluate whether aqueous humor levels of asymmetric dimethylarginine (ADMA) are associated with monocyte chemoattractant protein-1 (MCP-1). N,N-dimethylarginine 115-119 C-C motif chemokine ligand 2 Homo sapiens 177-182 17591667-5 2008 A positive correlation between ADMA and MCP-1 levels in aqueous humor was found in control and uveitis patients (r = 0.33, p<0.05). N,N-dimethylarginine 31-35 C-C motif chemokine ligand 2 Homo sapiens 40-45 17965029-6 2008 A significant inhibitory effect of besifloxacin was observed at 0.1 mg/L for IL-1alpha, at 1 mg/L for G-CSF, IL-1ra and IL-6 and at 30 mg/L for GM-CSF, IL-12p40, IL-1beta, IL-8, IP-10, MCP-1 and MIP-1alpha. besifloxacin 35-47 C-C motif chemokine ligand 2 Homo sapiens 185-190 18656701-7 2008 Selective inhibitors of p38 MAPK (SB203580), JNK (SP600125) and ERK (PD98059) could suppress TNF-alpha-induced CCL2 and ICAM-1 expression, while only p38 MAPK and ERK inhibitors could suppress TNF-alpha-induced VCAM-1 expression. pyrazolanthrone 50-58 C-C motif chemokine ligand 2 Homo sapiens 111-115 18656701-7 2008 Selective inhibitors of p38 MAPK (SB203580), JNK (SP600125) and ERK (PD98059) could suppress TNF-alpha-induced CCL2 and ICAM-1 expression, while only p38 MAPK and ERK inhibitors could suppress TNF-alpha-induced VCAM-1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 69-76 C-C motif chemokine ligand 2 Homo sapiens 111-115 18574968-9 2008 Under the experimental conditions (pH = 4.41--11.07, Ccl2 = 1.23--4.50 mg/L), low pH and high chlorine concentration favored the generation of bromate. Chlorine 94-102 C-C motif chemokine ligand 2 Homo sapiens 53-57 18574968-9 2008 Under the experimental conditions (pH = 4.41--11.07, Ccl2 = 1.23--4.50 mg/L), low pH and high chlorine concentration favored the generation of bromate. Bromates 143-150 C-C motif chemokine ligand 2 Homo sapiens 53-57 19116667-5 2008 Pretreatment with the NF-kappaB inhibitor parthenolide provided evidence that Tat+/-morphine-induced release of MCP-1, IL-6 and TNF-alpha by astrocytes is NF-kappaB dependent. parthenolide 42-54 C-C motif chemokine ligand 2 Homo sapiens 112-117 18025836-5 2008 RESULTS: Olmesartan significantly inhibited the AGE-evoked ROS generation and reduced the expression levels of monocyte chemoattractant protein 1 in microvascular ECs. olmesartan 9-19 C-C motif chemokine ligand 2 Homo sapiens 111-145 18584038-7 2008 Pioglitazone and troglitazone demonstrated opposing actions on microglial CCL2 production that were TLR ligand-dependent. Pioglitazone 0-12 C-C motif chemokine ligand 2 Homo sapiens 74-78 19116667-5 2008 Pretreatment with the NF-kappaB inhibitor parthenolide provided evidence that Tat+/-morphine-induced release of MCP-1, IL-6 and TNF-alpha by astrocytes is NF-kappaB dependent. Morphine 84-92 C-C motif chemokine ligand 2 Homo sapiens 112-117 18584038-7 2008 Pioglitazone and troglitazone demonstrated opposing actions on microglial CCL2 production that were TLR ligand-dependent. Troglitazone 17-29 C-C motif chemokine ligand 2 Homo sapiens 74-78 19116667-7 2008 Similarly, chelating intracellular calcium ([Ca(2+)](i)) blocked Tat+/-morphine-evoked MCP-1 and IL-6 release, while artificially increasing the concentration of extracellular Ca(2+) reversed this effect. Calcium 35-42 C-C motif chemokine ligand 2 Homo sapiens 87-92 19116667-7 2008 Similarly, chelating intracellular calcium ([Ca(2+)](i)) blocked Tat+/-morphine-evoked MCP-1 and IL-6 release, while artificially increasing the concentration of extracellular Ca(2+) reversed this effect. Morphine 71-79 C-C motif chemokine ligand 2 Homo sapiens 87-92 18048089-6 2008 CCL2, CCL4 and CCL5 were positively associated with uPA/suPAR system. supar 56-61 C-C motif chemokine ligand 2 Homo sapiens 0-4 18855759-4 2008 Further, telmisartan was found to inhibit up-regulation of mRNA levels for monocyte chemoattractant protein-1, intercellular adhesion molecule-1 and vascular endothelial growth factor in AGEs-exposed ECs. Telmisartan 9-20 C-C motif chemokine ligand 2 Homo sapiens 75-144 17627770-9 2007 Selective inhibitors of p38 MAPK (SB203580), ERK (PD98059), and JNK (SP600125) could differentially inhibit the production of EGF, VEGF and CCL2, thereby suggesting a role for MAPKs in IL-31 functions. SB 203580 34-42 C-C motif chemokine ligand 2 Homo sapiens 140-144 18047927-7 2008 In the patients with acute rejection MCP-1 level was ten-fold higher than in the patients with a stable graft function (6.1+/-3.4 vs 0.6+/-0.4 ng/mg creatinine). Creatinine 149-159 C-C motif chemokine ligand 2 Homo sapiens 37-42 18053242-9 2007 In addition, donor and CP PBMC significantly induced an increase in IL-6, MCP-1 and TGFbeta levels under coculture conditions. cp pbmc 23-30 C-C motif chemokine ligand 2 Homo sapiens 74-79 17627770-9 2007 Selective inhibitors of p38 MAPK (SB203580), ERK (PD98059), and JNK (SP600125) could differentially inhibit the production of EGF, VEGF and CCL2, thereby suggesting a role for MAPKs in IL-31 functions. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 50-57 C-C motif chemokine ligand 2 Homo sapiens 140-144 17627770-9 2007 Selective inhibitors of p38 MAPK (SB203580), ERK (PD98059), and JNK (SP600125) could differentially inhibit the production of EGF, VEGF and CCL2, thereby suggesting a role for MAPKs in IL-31 functions. pyrazolanthrone 69-77 C-C motif chemokine ligand 2 Homo sapiens 140-144 17869220-5 2007 Other inducers of ER stress completely reproduced the effects of K-7174 including suppression of lipid accumulation, blockade of induction of adiponection and PPARgamma and maintenance of MCP-1 expression. K 7174 65-71 C-C motif chemokine ligand 2 Homo sapiens 188-193 17878405-3 2007 Preincubation of THP-1 cells with imidaprilat (50 nM; 4 h), an active metabolite of imidapril, reduced MCP-1-triggered THP-1 cell adhesion (P < 0.01). imidaprilat 34-45 C-C motif chemokine ligand 2 Homo sapiens 103-108 17878405-3 2007 Preincubation of THP-1 cells with imidaprilat (50 nM; 4 h), an active metabolite of imidapril, reduced MCP-1-triggered THP-1 cell adhesion (P < 0.01). imidapril 34-43 C-C motif chemokine ligand 2 Homo sapiens 103-108 17878405-6 2007 Imidaprilat attenuated MCP-1-induced PKC activation and integrin up-regulation in THP-1 cells. imidaprilat 0-11 C-C motif chemokine ligand 2 Homo sapiens 23-28 17995524-2 2007 We and others observed that IgA itself could directly activate mesangial cells to produce monocyte chemotactic peptide-1 (MCP-1), interleukin-6 (IL-6) and transforming growth factor-beta (TGF-beta) and this was suppressed by the treatment with steroid or angiotensin receptor blocker (ARB). Steroids 244-251 C-C motif chemokine ligand 2 Homo sapiens 90-120 17878405-8 2007 In attempt to elucidate the mechanisms for the modulation of PKC activity by imidaprilat, we found that MCP-1 or PMA increased labile zinc in THP-1 cells, which was canceled by imidaprilat. imidaprilat 77-88 C-C motif chemokine ligand 2 Homo sapiens 104-109 17923111-5 2007 Moreover, LPA1 and LPA3 siRNA also inhibited LPA-enhanced IL-1-dependent long-term IL-8 and MCP-1 mRNA expression, and subsequent THP-1 cell chemotaxis toward LPA-treated HUVEC-conditioned media. lysophosphatidic acid 10-13 C-C motif chemokine ligand 2 Homo sapiens 92-97 17923111-5 2007 Moreover, LPA1 and LPA3 siRNA also inhibited LPA-enhanced IL-1-dependent long-term IL-8 and MCP-1 mRNA expression, and subsequent THP-1 cell chemotaxis toward LPA-treated HUVEC-conditioned media. lysophosphatidic acid 19-22 C-C motif chemokine ligand 2 Homo sapiens 92-97 18036447-3 2007 METHODS: Monocyte chemoattractant protein-1 was measured at baseline (n = 4,244), 4 months (n = 3,603), and 12 months (n = 2,950), and correlated with clinical events in the Z phase of the A to Z (Aggrastat to Zocor) trial, which compared early intensive versus delayed and less intensive statin therapy after ACS. Tirofiban 197-206 C-C motif chemokine ligand 2 Homo sapiens 9-43 18036447-3 2007 METHODS: Monocyte chemoattractant protein-1 was measured at baseline (n = 4,244), 4 months (n = 3,603), and 12 months (n = 2,950), and correlated with clinical events in the Z phase of the A to Z (Aggrastat to Zocor) trial, which compared early intensive versus delayed and less intensive statin therapy after ACS. Simvastatin 210-215 C-C motif chemokine ligand 2 Homo sapiens 9-43 17499741-3 2007 Resveratrol treatment inhibited 125I-MCP-1 binding to THP-1 cells; 31, 56, 84% decrease for 10, 50 and 100 microM resveratrol, in the absence of any effect on receptor affinity. Resveratrol 0-11 C-C motif chemokine ligand 2 Homo sapiens 37-42 17949278-2 2007 In the present study, a series of human MCP-1 promoter reporter genes were constructed to illustrate elements involved in antioxidant dimethyl sulfoxide (DMSO) inhibition of MCP-1 gene expression. Dimethyl Sulfoxide 134-152 C-C motif chemokine ligand 2 Homo sapiens 40-45 17949278-2 2007 In the present study, a series of human MCP-1 promoter reporter genes were constructed to illustrate elements involved in antioxidant dimethyl sulfoxide (DMSO) inhibition of MCP-1 gene expression. Dimethyl Sulfoxide 134-152 C-C motif chemokine ligand 2 Homo sapiens 174-179 17949278-2 2007 In the present study, a series of human MCP-1 promoter reporter genes were constructed to illustrate elements involved in antioxidant dimethyl sulfoxide (DMSO) inhibition of MCP-1 gene expression. Dimethyl Sulfoxide 154-158 C-C motif chemokine ligand 2 Homo sapiens 40-45 17949278-2 2007 In the present study, a series of human MCP-1 promoter reporter genes were constructed to illustrate elements involved in antioxidant dimethyl sulfoxide (DMSO) inhibition of MCP-1 gene expression. Dimethyl Sulfoxide 154-158 C-C motif chemokine ligand 2 Homo sapiens 174-179 17949278-3 2007 MCP-1 secretion and mRNA expression and transcription activity stimulated by TNF-alpha or IL-1beta were significantly inhibited by 1% DMSO in alveolar type II epithelial cells (A549). Dimethyl Sulfoxide 134-138 C-C motif chemokine ligand 2 Homo sapiens 0-5 17823354-6 2007 Effect of CCL2 on PA-SMC proliferation and migration was assessed using [3H]thymidine incorporation and a modified Boyden"s chamber. pa-smc 18-24 C-C motif chemokine ligand 2 Homo sapiens 10-14 17499741-3 2007 Resveratrol treatment inhibited 125I-MCP-1 binding to THP-1 cells; 31, 56, 84% decrease for 10, 50 and 100 microM resveratrol, in the absence of any effect on receptor affinity. Resveratrol 114-125 C-C motif chemokine ligand 2 Homo sapiens 37-42 17490777-0 2007 Monocyte chemoattractant protein-1 promoter -2518 polymorphism is associated with post-challenge insulin and glucose levels in non-diabetic Japanese subjects. Glucose 109-116 C-C motif chemokine ligand 2 Homo sapiens 0-34 17499741-4 2007 The inhibitory effect of resveratrol on 125I-MCP-1 binding to THP-1 cells and on CCR2 protein expression determined by FACS analysis was attenuated by treatment with L-NAME (NOS inhibitor), PD98059 (MAPK inhibitor) and LY294002 (PI3K inhibitor), whereas neither X/XO (reactive oxygen species generator) nor ICI182780 (estrogen receptor antagonist) had any effect. Resveratrol 25-36 C-C motif chemokine ligand 2 Homo sapiens 45-50 17499741-4 2007 The inhibitory effect of resveratrol on 125I-MCP-1 binding to THP-1 cells and on CCR2 protein expression determined by FACS analysis was attenuated by treatment with L-NAME (NOS inhibitor), PD98059 (MAPK inhibitor) and LY294002 (PI3K inhibitor), whereas neither X/XO (reactive oxygen species generator) nor ICI182780 (estrogen receptor antagonist) had any effect. NG-Nitroarginine Methyl Ester 166-172 C-C motif chemokine ligand 2 Homo sapiens 45-50 17490777-1 2007 We investigated that the association of MCP-1 polymorphism at position -2518 with insulin sensitivity and insulin secretion by measuring the fasting and post-challenge glucose and insulin levels during 75g OGTT in 409 non-diabetic Japanese subjects. Glucose 168-175 C-C motif chemokine ligand 2 Homo sapiens 40-45 17490777-9 2007 The present study demonstrates that the A/A polymorphism of the MCP-1 gene at position -2518 is associated with insulin resistance during glucose loading in non-diabetic Japanese subjects. Glucose 138-145 C-C motif chemokine ligand 2 Homo sapiens 64-69 17700511-0 2007 Dexamethasone modulates interleukin-12 production by inducing monocyte chemoattractant protein-1 in human dendritic cells. Dexamethasone 0-13 C-C motif chemokine ligand 2 Homo sapiens 62-96 17700511-2 2007 This study evaluated the gene and protein expression of monocyte chemoattractant protein-1 (MCP-1), and its relationship with interleukin-12 and interleukin-10 synthesis, in human monocyte-derived dendritic cells exposed to dexamethasone. Dexamethasone 224-237 C-C motif chemokine ligand 2 Homo sapiens 56-90 17700511-2 2007 This study evaluated the gene and protein expression of monocyte chemoattractant protein-1 (MCP-1), and its relationship with interleukin-12 and interleukin-10 synthesis, in human monocyte-derived dendritic cells exposed to dexamethasone. Dexamethasone 224-237 C-C motif chemokine ligand 2 Homo sapiens 92-97 17700511-4 2007 Our results showed that dexamethasone-primed mature dendritic cells expressed low levels of interleukin-12, and, at the opposite, high levels of interleukin-10 and MCP-1. Dexamethasone 24-37 C-C motif chemokine ligand 2 Homo sapiens 164-169 17700511-5 2007 Transfection experiments confirmed the ability of dexamethasone to activate MCP-1 gene promoter. Dexamethasone 50-63 C-C motif chemokine ligand 2 Homo sapiens 76-81 17700511-7 2007 The addition of anti-MCP-1 blocking antibody depressed MCP-1 release, and increased interleukin-12 production in dexamethasone-treated dendritic cells, thus demonstrating that interleukin-12 downregulation is largely dependent on MCP-1 overexpression. Dexamethasone 113-126 C-C motif chemokine ligand 2 Homo sapiens 21-26 17936526-6 2007 Thus, DNBS, isoeugenol, eugenol and hydroxycitronellal consistently modulated CCR5, CCL27, CCL2 and CCR7, respectively, whereas the CXCL10 gene was regulated by SDS. 2,4-dinitrofluorobenzene sulfonic acid 6-10 C-C motif chemokine ligand 2 Homo sapiens 84-88 17975143-10 2007 CONCLUSIONS: MCP-1 SNP-2518 may be a valuable genetic marker for assessing the risk of developing distant metastasis after the radiotherapy in NPC patients. snp-2518 19-27 C-C motif chemokine ligand 2 Homo sapiens 13-18 18084847-2 2007 We have previously shown that nifedipine, one of the most popular DHPs, blocks tumour necrosis factor-alpha (TNF-alpha)-induced monocyte chemoattractant protein-1 as well as vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells by suppressing reactive oxygen species generation (ROS). Nifedipine 30-40 C-C motif chemokine ligand 2 Homo sapiens 128-162 18084847-2 2007 We have previously shown that nifedipine, one of the most popular DHPs, blocks tumour necrosis factor-alpha (TNF-alpha)-induced monocyte chemoattractant protein-1 as well as vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells by suppressing reactive oxygen species generation (ROS). dhps 66-70 C-C motif chemokine ligand 2 Homo sapiens 128-162 17936526-6 2007 Thus, DNBS, isoeugenol, eugenol and hydroxycitronellal consistently modulated CCR5, CCL27, CCL2 and CCR7, respectively, whereas the CXCL10 gene was regulated by SDS. isoeugenol 12-22 C-C motif chemokine ligand 2 Homo sapiens 84-88 17936526-6 2007 Thus, DNBS, isoeugenol, eugenol and hydroxycitronellal consistently modulated CCR5, CCL27, CCL2 and CCR7, respectively, whereas the CXCL10 gene was regulated by SDS. Eugenol 15-22 C-C motif chemokine ligand 2 Homo sapiens 84-88 17936526-6 2007 Thus, DNBS, isoeugenol, eugenol and hydroxycitronellal consistently modulated CCR5, CCL27, CCL2 and CCR7, respectively, whereas the CXCL10 gene was regulated by SDS. hydroxycitronellal 36-54 C-C motif chemokine ligand 2 Homo sapiens 84-88 17704101-9 2007 We further studied effects of the pregnancy-associated hormones, estrogen, progesterone or HCG on CCL2 secretion by DSC. Progesterone 75-87 C-C motif chemokine ligand 2 Homo sapiens 98-102 17938235-5 2007 We show that Galpha(q)-deficient neutrophils and dendritic cells (DCs) make defective calcium and chemotactic responses upon stimulation with N-formyl methionyl leucyl phenylalanine and CC chemokine ligand (CCL) 3 (neutrophils), or upon stimulation with CCL2, CCL19, CCL21, and CXC chemokine ligand (CXCL) 12 (DCs). galpha(q) 13-22 C-C motif chemokine ligand 2 Homo sapiens 254-258 18167242-1 2007 OBJECTIVE: To investigate the influence of atorvastatin (ATOR) on the expression of monocyte chemoattractant protein-1 (MCP-1) induced by high concentration glucose in peritoneal mesothelial cells (PMCs) and the possible mechanism thereof. Atorvastatin 43-55 C-C motif chemokine ligand 2 Homo sapiens 84-118 18167242-1 2007 OBJECTIVE: To investigate the influence of atorvastatin (ATOR) on the expression of monocyte chemoattractant protein-1 (MCP-1) induced by high concentration glucose in peritoneal mesothelial cells (PMCs) and the possible mechanism thereof. Atorvastatin 43-55 C-C motif chemokine ligand 2 Homo sapiens 120-125 18167242-1 2007 OBJECTIVE: To investigate the influence of atorvastatin (ATOR) on the expression of monocyte chemoattractant protein-1 (MCP-1) induced by high concentration glucose in peritoneal mesothelial cells (PMCs) and the possible mechanism thereof. Atorvastatin 57-61 C-C motif chemokine ligand 2 Homo sapiens 84-118 18167242-1 2007 OBJECTIVE: To investigate the influence of atorvastatin (ATOR) on the expression of monocyte chemoattractant protein-1 (MCP-1) induced by high concentration glucose in peritoneal mesothelial cells (PMCs) and the possible mechanism thereof. Atorvastatin 57-61 C-C motif chemokine ligand 2 Homo sapiens 120-125 18167242-1 2007 OBJECTIVE: To investigate the influence of atorvastatin (ATOR) on the expression of monocyte chemoattractant protein-1 (MCP-1) induced by high concentration glucose in peritoneal mesothelial cells (PMCs) and the possible mechanism thereof. Glucose 157-164 C-C motif chemokine ligand 2 Homo sapiens 84-118 18167242-1 2007 OBJECTIVE: To investigate the influence of atorvastatin (ATOR) on the expression of monocyte chemoattractant protein-1 (MCP-1) induced by high concentration glucose in peritoneal mesothelial cells (PMCs) and the possible mechanism thereof. Glucose 157-164 C-C motif chemokine ligand 2 Homo sapiens 120-125 18167242-5 2007 Glucose dose- and time-dependently reduced the protein expression of IkappaBalpha in the PMCs and increased the p65 expression in the nucleus, and accelerated the PMCs to express MCP-1 mRNA and protein (P < 0.05 and P < 0.01). Glucose 0-7 C-C motif chemokine ligand 2 Homo sapiens 179-184 18167242-6 2007 PDTC dose-dependently inhibited the acceleration of expression of MCP-1 mRNA and protein in the PMCs induced by high concentration glucose (P < 0.05 or P < 0.01). Glucose 131-138 C-C motif chemokine ligand 2 Homo sapiens 66-71 18167242-7 2007 ATOR dose-dependently increased the IkappaBalpha expression, decreased the p65 expression in nucleus, and decreased the expression of MCP-1 mRNA and protein (P < 0.05 or P < 0.01). Atorvastatin 0-4 C-C motif chemokine ligand 2 Homo sapiens 134-139 18167242-8 2007 CONCLUSION: High concentration glucose induces PMCs to express MCP-1 in a time- and dose-dependent manner. Glucose 31-38 C-C motif chemokine ligand 2 Homo sapiens 63-68 17320090-8 2007 Compared to placebo (ANOVA and Tukey"s test), flavonoids significantly reduced serum 8-isoprostans (p<0.000) and Ox-LDL levels (p<0.000) (by 38 and 29%, respectively), as well as hsCRP (p<0.007) and MCP-1 (p<0.001) levels (by 23 and 29%, respectively). Flavonoids 46-56 C-C motif chemokine ligand 2 Homo sapiens 208-213 18167242-0 2007 [Influence of atorvastatin on the expression of monocyte chemoattractant protein-1 in peritoneal mesothelial cells by high glucose]. Atorvastatin 14-26 C-C motif chemokine ligand 2 Homo sapiens 48-82 18167242-0 2007 [Influence of atorvastatin on the expression of monocyte chemoattractant protein-1 in peritoneal mesothelial cells by high glucose]. Glucose 123-130 C-C motif chemokine ligand 2 Homo sapiens 48-82 17878996-5 2007 Our data show that among other effects, EGCG treatment reduces expression of two integrins (alpha5 and beta3) and a chemokine (MCP1), resulting in a lower adhesion of mast cells associated with a decreased potential to produce signals eliciting monocyte recruitment. epigallocatechin gallate 40-44 C-C motif chemokine ligand 2 Homo sapiens 127-131 17704101-10 2007 CCL2 secretion by DSC was up-regulated by estrogen, progesterone or HCG. Progesterone 52-64 C-C motif chemokine ligand 2 Homo sapiens 0-4 17704101-12 2007 CCL2 is secreted in an autocrine manner through the ERK/MAPK pathway, and is up-regulated by the pregnancy-associated hormones, estrogen, progesterone and HCG, which suggests that CCL2 may play an important role at materno-fetal interface. Progesterone 138-150 C-C motif chemokine ligand 2 Homo sapiens 0-4 17704101-12 2007 CCL2 is secreted in an autocrine manner through the ERK/MAPK pathway, and is up-regulated by the pregnancy-associated hormones, estrogen, progesterone and HCG, which suggests that CCL2 may play an important role at materno-fetal interface. Progesterone 138-150 C-C motif chemokine ligand 2 Homo sapiens 180-184 17767550-4 2007 The aim of this study was to assess MCP-1 levels in patients with HH and correlate these results with HFE status and iron indexes. Iron 117-121 C-C motif chemokine ligand 2 Homo sapiens 36-41 17884451-10 2007 Plasma level of monocyte chemoattractant protein 1 was decreased in the rosiglitazone group compared with the level at baseline (392 +/- 42 and 273 +/- 40 pg/mL, respectively). Rosiglitazone 72-85 C-C motif chemokine ligand 2 Homo sapiens 16-50 17767550-11 2007 This study suggests for the first time that a differential expression of MCP-1 protein in patients with HH is associated with the specific HFE genetic component for iron overload. Iron 165-169 C-C motif chemokine ligand 2 Homo sapiens 73-78 17937289-8 2007 Four product pathways are energetically feasible for DDVP degradation initiated by OH radicals in the atmosphere and are consistent with the experimentally observed products CCl2O and CO, but the additional products CCl2CHO, (CH3O)2P(O)OH, HO2, and a closed-shell organophosphorus compound denoted P10 are also predicted. oh radicals 83-94 C-C motif chemokine ligand 2 Homo sapiens 174-178 18161306-10 2007 CONCLUSION: EPZ could inhibit H2O2-induced ICAM-1, VCAM-1 and MCP-1 expression in ECV-304 and could inhibit the adherence of monocytes to endothelial cell, which may result in the protect effect in endothelial cells. Hydrogen Peroxide 30-34 C-C motif chemokine ligand 2 Homo sapiens 62-67 17696452-12 2007 Inhibition of adenosine elimination by EHNA or phloridzin raised apical adenosine levels by >3-fold and stimulated IL-13 and MCP-1 secretion by 6-fold. Adenosine 14-23 C-C motif chemokine ligand 2 Homo sapiens 128-133 17696452-12 2007 Inhibition of adenosine elimination by EHNA or phloridzin raised apical adenosine levels by >3-fold and stimulated IL-13 and MCP-1 secretion by 6-fold. 9-(2-hydroxy-3-nonyl)adenine 39-43 C-C motif chemokine ligand 2 Homo sapiens 128-133 17824649-3 2007 B3LYP/6-31G* calculations show preferential :CCl2 addition to substituted benzocyclopropene through electrophilic attack on the benzocyclopropene pi-system (Ea = 1.1-2.4 kcal/mol) rather than C-C sigma-bond insertion into the cyclopropenyl moiety (Ea = 5-24 kcal/mol). Bicyclo[4.1.0]hepta-1,3,5-triene 74-91 C-C motif chemokine ligand 2 Homo sapiens 45-49 17824649-3 2007 B3LYP/6-31G* calculations show preferential :CCl2 addition to substituted benzocyclopropene through electrophilic attack on the benzocyclopropene pi-system (Ea = 1.1-2.4 kcal/mol) rather than C-C sigma-bond insertion into the cyclopropenyl moiety (Ea = 5-24 kcal/mol). Bicyclo[4.1.0]hepta-1,3,5-triene 128-145 C-C motif chemokine ligand 2 Homo sapiens 45-49 17892360-5 2007 OxNEFA have potent monocyte chemotactic activity and LysoPC upregulates inflammatory mediators, including cytokines, adhesion molecules and the chemotactic mediator MCP-1. oxnefa 0-6 C-C motif chemokine ligand 2 Homo sapiens 165-170 17876051-8 2007 Kaempferol suppressed the expression of proinflammatory cytokine interleukin-6 and chemokines interleukin-8, monocyte chemoattractant protein-1, and regulated on activation, normal T-cell expressed and secreted. kaempferol 0-10 C-C motif chemokine ligand 2 Homo sapiens 109-143 17645690-7 2007 Interestingly, melatonin showed a suppressive effect on the expression of CC chemokine subfamily genes, including CCL2/MCP1, CCL3/MIP1 alpha, CCL4/MIP1 beta, CCL5/RANTES, CCL8/MCP2, CCL20/MDC, and CCL22/MIP3 alpha, in LPS-stimulated PBMCs. Melatonin 15-24 C-C motif chemokine ligand 2 Homo sapiens 114-118 17645690-7 2007 Interestingly, melatonin showed a suppressive effect on the expression of CC chemokine subfamily genes, including CCL2/MCP1, CCL3/MIP1 alpha, CCL4/MIP1 beta, CCL5/RANTES, CCL8/MCP2, CCL20/MDC, and CCL22/MIP3 alpha, in LPS-stimulated PBMCs. Melatonin 15-24 C-C motif chemokine ligand 2 Homo sapiens 119-123 17645690-9 2007 Among the CC chemokine subfamily genes, particularly, the expression of CCL2 and CCL5 was markedly downregulated by melatonin in LPS-stimulated PBMCs. Melatonin 116-125 C-C motif chemokine ligand 2 Homo sapiens 72-76 17645690-12 2007 ), whereas melatonin pretreatment (153.0 +/- 3.8 pg/mL) inhibited the LPS-induced secretion of CCL2. Melatonin 11-20 C-C motif chemokine ligand 2 Homo sapiens 95-99 17645690-14 2007 Taken together, these results suggest that melatonin may have a suppressive effect on LPS-induced expression of CC chemokine genes, especially CCL2 and CCL5, which may explain its beneficial effects in the treatment of various inflammatory conditions. Melatonin 43-52 C-C motif chemokine ligand 2 Homo sapiens 143-147 17604001-6 2007 Furthermore, K-7174-elicited UPR abrogated induction of MCP-1 and iNOS not only by TNF-alpha but also by medium conditioned by activated macrophages. K 7174 13-19 C-C motif chemokine ligand 2 Homo sapiens 56-61 17618604-4 2007 In the disease-specific EC, glucose treatment resulted also in moderately inhibited cell growth by 5-10%, increased basal expression of VCAM-1 by 10-20%, and an enhanced release of monocyte-chemoattractant-protein-1 (MCP-1) by 40-70%. Glucose 28-35 C-C motif chemokine ligand 2 Homo sapiens 181-215 17618604-4 2007 In the disease-specific EC, glucose treatment resulted also in moderately inhibited cell growth by 5-10%, increased basal expression of VCAM-1 by 10-20%, and an enhanced release of monocyte-chemoattractant-protein-1 (MCP-1) by 40-70%. Glucose 28-35 C-C motif chemokine ligand 2 Homo sapiens 217-222 17097661-0 2007 Short-term high glucose exposure induces monocyte-endothelial cells adhesion and transmigration by increasing VCAM-1 and MCP-1 expression in human aortic endothelial cells. Glucose 16-23 C-C motif chemokine ligand 2 Homo sapiens 121-126 17658879-3 2007 A conventional interpretation of these band shifts would suggest that the CCl2 fragment of DCCl3 is a stronger hydrogen-bond acceptor than the BF2 fragment of a BF4- group. dccl3 91-96 C-C motif chemokine ligand 2 Homo sapiens 74-78 17658879-3 2007 A conventional interpretation of these band shifts would suggest that the CCl2 fragment of DCCl3 is a stronger hydrogen-bond acceptor than the BF2 fragment of a BF4- group. Hydrogen 111-119 C-C motif chemokine ligand 2 Homo sapiens 74-78 17889312-6 2007 Concentrations of tumor necrosis factor-alpha and monocyte chemoattractant protein-1 in BALF in the alcohol consumption group were increased. Alcohols 100-107 C-C motif chemokine ligand 2 Homo sapiens 50-84 17097661-3 2007 HAECs stimulated with 25mM d(+)glucose (HG) for not more than 12h, exhibited rapid up-regulation of vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1 (MCP-1) mRNA and protein. Glucose 27-38 C-C motif chemokine ligand 2 Homo sapiens 147-181 17097661-3 2007 HAECs stimulated with 25mM d(+)glucose (HG) for not more than 12h, exhibited rapid up-regulation of vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1 (MCP-1) mRNA and protein. Glucose 27-38 C-C motif chemokine ligand 2 Homo sapiens 183-188 17442054-3 2007 Pre-treatment of immortalized HBMEC with atorvastatin (50 nmol/L to 1 micromol/L) dose-dependently prevented an inflammatory up-regulation of monocyte chemoattractant protein-1/CCL2 but not of interleukin-8/CXCL8 and intercellular adhesion molecule-1 expression by tumor necrosis factor-alpha or interleukin-1beta. Atorvastatin 41-53 C-C motif chemokine ligand 2 Homo sapiens 142-176 18048020-4 2007 CNTO2424 down-regulates poly(I:C)-induced production of IL-6, IL-8, MCP-1, RANTES, and IP-10 in human lung epithelial cells. poly 24-28 C-C motif chemokine ligand 2 Homo sapiens 68-73 18048020-4 2007 CNTO2424 down-regulates poly(I:C)-induced production of IL-6, IL-8, MCP-1, RANTES, and IP-10 in human lung epithelial cells. Carbon 0-1 C-C motif chemokine ligand 2 Homo sapiens 68-73 17507084-0 2007 Histamine downregulates monocyte CCL2 production through the histamine H4 receptor. Histamine 0-9 C-C motif chemokine ligand 2 Homo sapiens 33-37 17403137-10 2007 This study reveals that the MKP-1 and MCP-1 as novel mediators of biological effects of Dex may help developing better therapeutic strategies for the treatment of patients with neuroinflammatory diseases. Dexamethasone 88-91 C-C motif chemokine ligand 2 Homo sapiens 38-43 17641061-7 2007 Although IFN-gamma failed to protect neutrophils from cell death at a higher dose of LPS, the p38 MAPK inhibitor SB203580 dramatically increased MCP-1 release and neutrophil survival at this LPS concentration. SB 203580 113-121 C-C motif chemokine ligand 2 Homo sapiens 145-150 17442054-3 2007 Pre-treatment of immortalized HBMEC with atorvastatin (50 nmol/L to 1 micromol/L) dose-dependently prevented an inflammatory up-regulation of monocyte chemoattractant protein-1/CCL2 but not of interleukin-8/CXCL8 and intercellular adhesion molecule-1 expression by tumor necrosis factor-alpha or interleukin-1beta. Atorvastatin 41-53 C-C motif chemokine ligand 2 Homo sapiens 177-181 17442054-5 2007 Like immortalized HBMEC, primary HBMEC also showed a reduction of claudin-3 and of inducible CCL2 expression following atorvastatin pre-treatment. Atorvastatin 119-131 C-C motif chemokine ligand 2 Homo sapiens 93-97 17655880-0 2007 D-Psicose inhibits the expression of MCP-1 induced by high-glucose stimulation in HUVECs. psicose 0-9 C-C motif chemokine ligand 2 Homo sapiens 37-42 17529908-10 2007 These results provide evidence that in whole blood and PBMCs, DMSO regulates MCP-1 gene expression by decreasing the induction of MCP-1 mRNA. Dimethyl Sulfoxide 62-66 C-C motif chemokine ligand 2 Homo sapiens 77-82 17529908-10 2007 These results provide evidence that in whole blood and PBMCs, DMSO regulates MCP-1 gene expression by decreasing the induction of MCP-1 mRNA. Dimethyl Sulfoxide 62-66 C-C motif chemokine ligand 2 Homo sapiens 130-135 17631057-0 2007 Inhibitory effects of Zoagumhwan water extract and berberine on angiotensin II-induced monocyte chemoattractant protein (MCP)-1 expression and monocyte adhesion to endothelial cells. zoagumhwan 22-32 C-C motif chemokine ligand 2 Homo sapiens 87-127 17631057-0 2007 Inhibitory effects of Zoagumhwan water extract and berberine on angiotensin II-induced monocyte chemoattractant protein (MCP)-1 expression and monocyte adhesion to endothelial cells. Water 33-38 C-C motif chemokine ligand 2 Homo sapiens 87-127 17631057-0 2007 Inhibitory effects of Zoagumhwan water extract and berberine on angiotensin II-induced monocyte chemoattractant protein (MCP)-1 expression and monocyte adhesion to endothelial cells. Berberine 51-60 C-C motif chemokine ligand 2 Homo sapiens 87-127 17631057-3 2007 In the present study, we found that the water extract of ZoaGumHwan (ZGH), a Korean herbal remedy, dose-dependently inhibited Ang II-induced U937 monocyte adhesion to human umbilical vein endothelial cells (HUVECs) and mRNA expression of MCP-1 in HUVECs and C-C chemokine receptor 2 (CCR-2) in U937 cells. Water 40-45 C-C motif chemokine ligand 2 Homo sapiens 238-243 17631057-5 2007 Berberine, a major component of Coptis chinensis Franch, also showed similar effects on ROS production and MCP-1 expression induced by Ang II. Berberine 0-9 C-C motif chemokine ligand 2 Homo sapiens 107-112 17512775-8 2007 Using the Boyden chamber motility assay, it was shown that both spontaneous and monocyte chemotactic protein (MCP-1)-induced lymphocyte motility were strongly reduced by (99m)Tc-HMPAO-labelling. Technetium Tc 99m Exametazime 175-183 C-C motif chemokine ligand 2 Homo sapiens 110-115 17529908-3 2007 The antioxidants dimethyl sulfoxide (DMSO), N-acetyl cysteine, and dimethyl thiourea significantly inhibited lipopolysaccharide (LPS)-induced MCP-1 production in either whole blood or isolated blood cells. Dimethyl Sulfoxide 17-35 C-C motif chemokine ligand 2 Homo sapiens 142-147 17529908-3 2007 The antioxidants dimethyl sulfoxide (DMSO), N-acetyl cysteine, and dimethyl thiourea significantly inhibited lipopolysaccharide (LPS)-induced MCP-1 production in either whole blood or isolated blood cells. Dimethyl Sulfoxide 37-41 C-C motif chemokine ligand 2 Homo sapiens 142-147 17529908-3 2007 The antioxidants dimethyl sulfoxide (DMSO), N-acetyl cysteine, and dimethyl thiourea significantly inhibited lipopolysaccharide (LPS)-induced MCP-1 production in either whole blood or isolated blood cells. Acetylcysteine 44-61 C-C motif chemokine ligand 2 Homo sapiens 142-147 17529908-3 2007 The antioxidants dimethyl sulfoxide (DMSO), N-acetyl cysteine, and dimethyl thiourea significantly inhibited lipopolysaccharide (LPS)-induced MCP-1 production in either whole blood or isolated blood cells. 1,3-dimethylthiourea 67-84 C-C motif chemokine ligand 2 Homo sapiens 142-147 17529908-5 2007 Exogenous ROI (either hydrogen peroxide or O2 generated by xanthine/xanthine oxidase) stimulated MCP-1 production, which was also inhibited by DMSO. Hydrogen Peroxide 22-39 C-C motif chemokine ligand 2 Homo sapiens 97-102 17529908-5 2007 Exogenous ROI (either hydrogen peroxide or O2 generated by xanthine/xanthine oxidase) stimulated MCP-1 production, which was also inhibited by DMSO. Oxygen 43-45 C-C motif chemokine ligand 2 Homo sapiens 97-102 17529908-5 2007 Exogenous ROI (either hydrogen peroxide or O2 generated by xanthine/xanthine oxidase) stimulated MCP-1 production, which was also inhibited by DMSO. Dimethyl Sulfoxide 143-147 C-C motif chemokine ligand 2 Homo sapiens 97-102 17529908-7 2007 The level of inhibition was addressed in experiments which demonstrated that DMSO significantly decreased MCP-1 mRNA induced by LPS in whole blood and PBMCs. Dimethyl Sulfoxide 77-81 C-C motif chemokine ligand 2 Homo sapiens 106-111 17655880-0 2007 D-Psicose inhibits the expression of MCP-1 induced by high-glucose stimulation in HUVECs. Glucose 59-66 C-C motif chemokine ligand 2 Homo sapiens 37-42 17655880-3 2007 Recent report indicates that MCP-1 is induced by glucose-stimulation, raising the important link between diabetes mellitus and atherosclerosis. Glucose 49-56 C-C motif chemokine ligand 2 Homo sapiens 29-34 17655880-5 2007 In this study, we examined the effects of d-psicose on MCP-1 expression in human umbilical vein endothelial cells (HUVECs). psicose 42-51 C-C motif chemokine ligand 2 Homo sapiens 55-60 17655880-6 2007 Results showed that MCP-1 mRNA and protein were stimulated following exposure to 22.4 mM glucose. Glucose 89-96 C-C motif chemokine ligand 2 Homo sapiens 20-25 17655880-7 2007 Transcriptional activity of MCP-1 promoter paralleled endogenous expression of the gene and this activity was dependent on the dose of d-glucose. Glucose 135-144 C-C motif chemokine ligand 2 Homo sapiens 28-33 17655880-9 2007 Next we used inhibitors of selected signal transduction pathways to show that high-glucose (HG) stimulated MCP-1 promoter activity was sensitive to p38-Mitogen-Activated Protein Kinase (p38-MAPK) pathway inhibitor. Glucose 83-90 C-C motif chemokine ligand 2 Homo sapiens 107-112 17655880-12 2007 Together, these results indicate that the d-psicose suppression of HG induced MCP-1 expression is mediated in part by inhibition of the p38-MAPK pathway and raise the possibility that d-psicose may be of therapeutic value in the treatment of diseases such as atherosclerosis. psicose 42-51 C-C motif chemokine ligand 2 Homo sapiens 78-83 17666914-6 2007 The expression of intracellular cell adhesion molecule (ICAM)-1, monocyte chemoattractant protein (MCP)-1, and interleukin (IL)-8 were attenuated by curcumin at both mRNA and protein level. Curcumin 149-157 C-C motif chemokine ligand 2 Homo sapiens 65-105 16842799-0 2007 Circulating chemoattractants RANTES, negatively related to endogenous androgens, and MCP-1 are differentially suppressed by hormone therapy and raloxifene. Raloxifene Hydrochloride 144-154 C-C motif chemokine ligand 2 Homo sapiens 85-90 17631136-8 2007 Fenofibrate also repressed the expression of the genes encoding 3 chemokines, CXCL10, CCL2, and CCL20, and repressed CXCL10 gene promoter activity in tumor necrosis factor-alpha-treated HT-29 cells. Fenofibrate 0-11 C-C motif chemokine ligand 2 Homo sapiens 86-90 17521728-7 2007 Furthermore, DOTAP-induced CCL2 expression is negatively regulated by the p38 pathway. 1,2-dioleoyloxy-3-(trimethylammonium)propane 13-18 C-C motif chemokine ligand 2 Homo sapiens 27-31 17521728-9 2007 Moreover, PI-3 kinase was shown to be involved in both activation of ERK and induction of CCL2 by DOTAP. 1,2-dioleoyloxy-3-(trimethylammonium)propane 98-103 C-C motif chemokine ligand 2 Homo sapiens 90-94 17521728-10 2007 DOTAP- induced CCL2 release was also confirmed in the draining lymph nodes. 1,2-dioleoyloxy-3-(trimethylammonium)propane 0-5 C-C motif chemokine ligand 2 Homo sapiens 15-19 17467667-4 2007 Palmitic acid (PA), the predominant saturated FFA released from adipose tissue, but not unsaturated FFA, induced an approximately 6-fold (p<0.05) increase in IP-10 gene expression (and 2- to 4-fold increases in IL-8, MCP-1, COX-2, and MIG). Palmitic Acid 0-13 C-C motif chemokine ligand 2 Homo sapiens 220-225 17763208-3 2007 CCL2 genomic variants (-2510A/G and Cys35Cys polymorphisms) were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). cys35cys 36-44 C-C motif chemokine ligand 2 Homo sapiens 0-4 17221363-10 2007 Moreover, plasma IL-1 beta, TNF-alpha and MCP-1 levels were positively correlated with clinical and well-establish biochemical parameters of pregnancy toxaemia, serum uric acid and proteinuria (p<0.01). Uric Acid 167-176 C-C motif chemokine ligand 2 Homo sapiens 42-47 17467667-4 2007 Palmitic acid (PA), the predominant saturated FFA released from adipose tissue, but not unsaturated FFA, induced an approximately 6-fold (p<0.05) increase in IP-10 gene expression (and 2- to 4-fold increases in IL-8, MCP-1, COX-2, and MIG). Palmitic Acid 15-17 C-C motif chemokine ligand 2 Homo sapiens 220-225 17460445-10 2007 RESULTS: The release of RANTES and MCP-1 was significantly upregulated by histamine compared with the control group. Histamine 74-83 C-C motif chemokine ligand 2 Homo sapiens 35-40 17293495-5 2007 Knockdown of IL-1 alpha abolished TLR-induced proliferation and suppressed TLR4-induced release of monocyte chemoattractant protein-1 (MCP-1) by VSMC, indicating that endogenous IL-1 alpha plays a crucial role in both responses. vsmc 145-149 C-C motif chemokine ligand 2 Homo sapiens 99-133 17293495-5 2007 Knockdown of IL-1 alpha abolished TLR-induced proliferation and suppressed TLR4-induced release of monocyte chemoattractant protein-1 (MCP-1) by VSMC, indicating that endogenous IL-1 alpha plays a crucial role in both responses. vsmc 145-149 C-C motif chemokine ligand 2 Homo sapiens 135-140 17577102-7 2007 Rosuvastatin inhibited the expressions of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA and protein levels. Rosuvastatin Calcium 0-12 C-C motif chemokine ligand 2 Homo sapiens 50-55 17296320-1 2007 OBJECTIVES: Platelet monocyte aggregates (PMA) and monocyte chemoattractant protein-1 (MCP-1) play a significant role in atherosclerotic disease but the effect of aspirin and their role in peripheral arterial disease (PAD) requires further investigation. Aspirin 163-170 C-C motif chemokine ligand 2 Homo sapiens 87-92 17587761-5 2007 N(omega)-nitro-L-arginine methyl ester (L-NAME) promoted MCP-1 expression in EC culture. NG-Nitroarginine Methyl Ester 0-38 C-C motif chemokine ligand 2 Homo sapiens 57-62 17587761-5 2007 N(omega)-nitro-L-arginine methyl ester (L-NAME) promoted MCP-1 expression in EC culture. NG-Nitroarginine Methyl Ester 40-46 C-C motif chemokine ligand 2 Homo sapiens 57-62 17587761-8 2007 Monocyte attachment to L-NAME- treated ECs increased Ca(2+) influx compared with non-treated ECs, which was prevented by the blockade of MCP1/CCR2. NG-Nitroarginine Methyl Ester 23-29 C-C motif chemokine ligand 2 Homo sapiens 137-141 17587761-9 2007 These findings suggest that increased production of MCP-1 caused by L-NAME contributes to the enhancement of Ca(2+) influx only when monocytes adhered to ECs and that this may accelerate TF expression in ECs triggered by monocyte adhesion. NG-Nitroarginine Methyl Ester 68-74 C-C motif chemokine ligand 2 Homo sapiens 52-57 17322416-10 2007 We further confirmed that sirolimus inhibited mRNA and protein expression of inflammatory cytokines IL-6, tumor necrosis factor-alpha, IL-8, and monocyte chemoattractant protein-1. Sirolimus 26-35 C-C motif chemokine ligand 2 Homo sapiens 145-179 16970955-0 2007 Ethanol beverages containing polyphenols decrease nuclear factor kappa-B activation in mononuclear cells and circulating MCP-1 concentrations in healthy volunteers during a fat-enriched diet. Ethanol 0-7 C-C motif chemokine ligand 2 Homo sapiens 121-126 16970955-0 2007 Ethanol beverages containing polyphenols decrease nuclear factor kappa-B activation in mononuclear cells and circulating MCP-1 concentrations in healthy volunteers during a fat-enriched diet. Polyphenols 29-40 C-C motif chemokine ligand 2 Homo sapiens 121-126 16970955-8 2007 Red wine intake and some ethanol beverages containing polyphenols (brandy and rum) prevented NF-kappaB activation and decreased MCP-1 release. red wine 0-8 C-C motif chemokine ligand 2 Homo sapiens 128-133 16970955-8 2007 Red wine intake and some ethanol beverages containing polyphenols (brandy and rum) prevented NF-kappaB activation and decreased MCP-1 release. Ethanol 25-32 C-C motif chemokine ligand 2 Homo sapiens 128-133 16970955-8 2007 Red wine intake and some ethanol beverages containing polyphenols (brandy and rum) prevented NF-kappaB activation and decreased MCP-1 release. Polyphenols 54-65 C-C motif chemokine ligand 2 Homo sapiens 128-133 16970955-8 2007 Red wine intake and some ethanol beverages containing polyphenols (brandy and rum) prevented NF-kappaB activation and decreased MCP-1 release. brandy 67-73 C-C motif chemokine ligand 2 Homo sapiens 128-133 16970955-8 2007 Red wine intake and some ethanol beverages containing polyphenols (brandy and rum) prevented NF-kappaB activation and decreased MCP-1 release. CHEMBL1235761 78-81 C-C motif chemokine ligand 2 Homo sapiens 128-133 16970955-9 2007 CONCLUSION: Consumption of moderate amounts of alcoholic drinks containing polyphenols decreases NF-kappaB activation in PBMCs and MCP-1 plasma levels during a fat-enriched diet. Polyphenols 75-86 C-C motif chemokine ligand 2 Homo sapiens 131-136 17474992-16 2007 Both hypoxia and CoCl2 also up-regulated HIF-1alpha and MCP-1 expression in human astrocytes. cobaltous chloride 17-22 C-C motif chemokine ligand 2 Homo sapiens 56-61 17238169-0 2007 Theoretical study on the methyl radical with chlorinated methyl radicals CH(3-n)Cln (n = 1, 2, 3) and CCl2. methyl radical 25-39 C-C motif chemokine ligand 2 Homo sapiens 102-106 17441793-8 2007 After 3 and 8 h of stimulation, codeine, but not meperidine, activated human mast cells to release monocyte chemoattractant protein-1 (CCL2), regulated on activation, normal T expressed and secreted (RANTES, CCL5) and interleukin-8 (CXCL 8) but not inducible protein-10 (CXCL10). Codeine 32-39 C-C motif chemokine ligand 2 Homo sapiens 99-133 17441793-8 2007 After 3 and 8 h of stimulation, codeine, but not meperidine, activated human mast cells to release monocyte chemoattractant protein-1 (CCL2), regulated on activation, normal T expressed and secreted (RANTES, CCL5) and interleukin-8 (CXCL 8) but not inducible protein-10 (CXCL10). Codeine 32-39 C-C motif chemokine ligand 2 Homo sapiens 135-139 17452168-0 2007 Elevated ICAM-1 and MCP-1 plasma levels in subjects at high cardiovascular risk are diminished by atorvastatin treatment. Atorvastatin 98-110 C-C motif chemokine ligand 2 Homo sapiens 20-25 17460254-0 2007 Mitomycin C upregulates IL-8 and MCP-1 chemokine expression via mitogen-activated protein kinases in corneal fibroblasts. Mitomycin 0-11 C-C motif chemokine ligand 2 Homo sapiens 33-38 17460254-6 2007 RESULTS: The expression of IL-8 and MCP-1 were upregulated after MMC treatment in a time- and concentration-dependent manner. Mitomycin 65-68 C-C motif chemokine ligand 2 Homo sapiens 36-41 17460254-9 2007 The MMC-related IL-8 and MCP-1 expression was inhibited by both a p38 inhibitor (SB203580) and an ERK inhibitor (PD98059). SB 203580 81-89 C-C motif chemokine ligand 2 Homo sapiens 25-30 17460254-9 2007 The MMC-related IL-8 and MCP-1 expression was inhibited by both a p38 inhibitor (SB203580) and an ERK inhibitor (PD98059). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 113-120 C-C motif chemokine ligand 2 Homo sapiens 25-30 17460254-10 2007 A JNK inhibitor (SP600125) reduced the expression of MMC-induced MCP-1 but not of IL-8. pyrazolanthrone 17-25 C-C motif chemokine ligand 2 Homo sapiens 65-70 17460254-10 2007 A JNK inhibitor (SP600125) reduced the expression of MMC-induced MCP-1 but not of IL-8. Mitomycin 53-56 C-C motif chemokine ligand 2 Homo sapiens 65-70 17460254-11 2007 CONCLUSIONS: MMC treatment upregulated the expression of IL-8 and MCP-1 mRNA and protein secretion by the activation of mitogen-activated protein kinases (MAPKs) in corneal fibroblasts. Mitomycin 13-16 C-C motif chemokine ligand 2 Homo sapiens 66-71 17379255-0 2007 (-)-Epigallocatechin-3-gallate inhibits monocyte chemotactic protein-1 expression in endothelial cells via blocking NF-kappaB signaling. epigallocatechin gallate 0-30 C-C motif chemokine ligand 2 Homo sapiens 40-70 17379255-3 2007 EGCG markedly inhibited the phorbol 12-myristate 13-acetate (PMA)-induced MCP-1 mRNA and protein levels in a dose-dependent manner. epigallocatechin gallate 0-4 C-C motif chemokine ligand 2 Homo sapiens 74-79 17379255-3 2007 EGCG markedly inhibited the phorbol 12-myristate 13-acetate (PMA)-induced MCP-1 mRNA and protein levels in a dose-dependent manner. Tetradecanoylphorbol Acetate 28-59 C-C motif chemokine ligand 2 Homo sapiens 74-79 17379255-3 2007 EGCG markedly inhibited the phorbol 12-myristate 13-acetate (PMA)-induced MCP-1 mRNA and protein levels in a dose-dependent manner. Tetradecanoylphorbol Acetate 61-64 C-C motif chemokine ligand 2 Homo sapiens 74-79 17379255-4 2007 EGCG was also found to reduce the MCP-1 transcriptional activity. epigallocatechin gallate 0-4 C-C motif chemokine ligand 2 Homo sapiens 34-39 17379255-9 2007 These results suggest that EGCG may exert an anti-inflammatory effect in endothelial cells by controlling MCP-1 expression, at least in part, mediated through the suppression of p38 MAPK and NF-kappaB activation. epigallocatechin gallate 27-31 C-C motif chemokine ligand 2 Homo sapiens 106-111 17391033-3 2007 In laser flash photolysis (LFP) experiments, CCl2 forms chromophoric ylides or oxides with pyridine, 2-picoline, thioanisole, and oxygen. ylides 69-75 C-C motif chemokine ligand 2 Homo sapiens 45-49 17391033-3 2007 In laser flash photolysis (LFP) experiments, CCl2 forms chromophoric ylides or oxides with pyridine, 2-picoline, thioanisole, and oxygen. pyridine 91-99 C-C motif chemokine ligand 2 Homo sapiens 45-49 17391033-3 2007 In laser flash photolysis (LFP) experiments, CCl2 forms chromophoric ylides or oxides with pyridine, 2-picoline, thioanisole, and oxygen. 2-picoline 101-111 C-C motif chemokine ligand 2 Homo sapiens 45-49 17391033-3 2007 In laser flash photolysis (LFP) experiments, CCl2 forms chromophoric ylides or oxides with pyridine, 2-picoline, thioanisole, and oxygen. methylphenylsulfide 113-124 C-C motif chemokine ligand 2 Homo sapiens 45-49 17391033-3 2007 In laser flash photolysis (LFP) experiments, CCl2 forms chromophoric ylides or oxides with pyridine, 2-picoline, thioanisole, and oxygen. Oxygen 130-136 C-C motif chemokine ligand 2 Homo sapiens 45-49 17391033-6 2007 It appears possible that CCl2 is rapidly captured by oxygen to afford a chromophoric dichlorocarbene carbonyl oxide. Oxygen 53-59 C-C motif chemokine ligand 2 Homo sapiens 25-29 17391033-6 2007 It appears possible that CCl2 is rapidly captured by oxygen to afford a chromophoric dichlorocarbene carbonyl oxide. dichlorocarbene carbonyl oxide 85-115 C-C motif chemokine ligand 2 Homo sapiens 25-29 20409851-10 2007 IL-6, IL-18, sICAM, and MCP-1 levels were reduced by valsartan (three-fold, P < .05). Valsartan 53-62 C-C motif chemokine ligand 2 Homo sapiens 24-29 17557268-3 2007 We measured the serum (sMCP-1) and dialysate MCP-1 (dMCP-1) concentrations of stable peritoneal dialysis (PD) patients and studied various factors affecting MCP-1 production. Dimyristoylphosphatidylcholine 52-56 C-C motif chemokine ligand 2 Homo sapiens 45-50 17206432-10 2007 Up-regulated expression and high circulating levels of MCP-1 in CDH patients with PPH suggest that MCP-1 may play a role in the development of PPH in CDH. [(1R)-1-amino-2-phenylethyl]phosphonic acid 82-85 C-C motif chemokine ligand 2 Homo sapiens 55-60 17206432-10 2007 Up-regulated expression and high circulating levels of MCP-1 in CDH patients with PPH suggest that MCP-1 may play a role in the development of PPH in CDH. [(1R)-1-amino-2-phenylethyl]phosphonic acid 82-85 C-C motif chemokine ligand 2 Homo sapiens 99-104 17238169-3 2007 In this paper, four chloride-related radical-radical reactions, i.e., CH3+CH(3-n)Cln (n = 1, 2, 3) and CH3+CCl2, are theoretically studied for the first time by means of the Gaussian-3//B3LYP potential energy surface survey combined with the master equation study over a wide range of temperatures and pressures. Chlorides 20-28 C-C motif chemokine ligand 2 Homo sapiens 107-111 17276989-4 2007 The GR antagonist, RU486, blocked the effect of the glucocorticoid dexamethasone (Dex) on MCP-1 mRNA stability in SMC culture. Mifepristone 19-24 C-C motif chemokine ligand 2 Homo sapiens 90-95 17276989-4 2007 The GR antagonist, RU486, blocked the effect of the glucocorticoid dexamethasone (Dex) on MCP-1 mRNA stability in SMC culture. Dexamethasone 67-80 C-C motif chemokine ligand 2 Homo sapiens 90-95 17276989-4 2007 The GR antagonist, RU486, blocked the effect of the glucocorticoid dexamethasone (Dex) on MCP-1 mRNA stability in SMC culture. Dexamethasone 82-85 C-C motif chemokine ligand 2 Homo sapiens 90-95 17276989-5 2007 Using a previously reported in vitro mRNA gel shift and stability assay, antibodies to the GR blocked the ability of cytoplasmic extracts from Dex-treated SMC to decay MCP-1 mRNA. Dexamethasone 143-146 C-C motif chemokine ligand 2 Homo sapiens 168-173 17276989-8 2007 Immunoprecipitation of GR in extracts from Dex-treated SMC followed by real-time reverse transcription-PCR demonstrated that endogenous GR was bound specifically to MCP-1 mRNA. Dexamethasone 43-46 C-C motif chemokine ligand 2 Homo sapiens 165-170 17276989-9 2007 The addition of exogenous rhGR blocked the ability of extracts from Dex-treated SMC to degrade MCP-1 mRNA, suggesting that exogenous rhGR can compete with an endogenous GR-containing degradative complex. Dexamethasone 68-71 C-C motif chemokine ligand 2 Homo sapiens 95-100 17400977-8 2007 There was a trend toward higher MCP-1 plasma concentrations in the AMIO group (P = 0.13). Amiodarone 67-71 C-C motif chemokine ligand 2 Homo sapiens 32-37 17240460-6 2007 Analysis of gene and protein expression determined a selectively increase of the pro-inflammatory cytokines monocyte chemoattractant protein (MCP)-1 and interleukin-8 (IL-8) following exposure to a pharmacological concentration of NFV and RTV. Nelfinavir 231-234 C-C motif chemokine ligand 2 Homo sapiens 108-148 17240460-6 2007 Analysis of gene and protein expression determined a selectively increase of the pro-inflammatory cytokines monocyte chemoattractant protein (MCP)-1 and interleukin-8 (IL-8) following exposure to a pharmacological concentration of NFV and RTV. Ritonavir 239-242 C-C motif chemokine ligand 2 Homo sapiens 108-148 17218539-0 2007 Hypochlorite-modified albumin colocalizes with RAGE in the artery wall and promotes MCP-1 expression via the RAGE-Erk1/2 MAP-kinase pathway. Hypochlorous Acid 0-12 C-C motif chemokine ligand 2 Homo sapiens 84-89 17360948-4 2007 Sufficient amounts of hydrogen peroxide were produced in HK-2 cells to stimulate the production of monocyte chemoattractant protein-1 (MCP-1), a key chemokine involved in monocyte/macrophage migration and activation of the proximal tubule, and to increase lactate dehydrogenase release into the medium. Hydrogen Peroxide 22-39 C-C motif chemokine ligand 2 Homo sapiens 99-133 17360948-4 2007 Sufficient amounts of hydrogen peroxide were produced in HK-2 cells to stimulate the production of monocyte chemoattractant protein-1 (MCP-1), a key chemokine involved in monocyte/macrophage migration and activation of the proximal tubule, and to increase lactate dehydrogenase release into the medium. Hydrogen Peroxide 22-39 C-C motif chemokine ligand 2 Homo sapiens 135-140 17360948-5 2007 The light chain-mediated effect on MCP-1 production was inhibited by co-incubation with 1,3-dimethyl-2-thiourea, which also inhibited lactate dehydrogenase release, and by pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB. 1,3-dimethylthiourea 88-111 C-C motif chemokine ligand 2 Homo sapiens 35-40 17255125-7 2007 PPAR-gamma"s activation with 15d-PGJ2 or pioglitazone reduced basal and TNF-alpha-stimulated MCP-1 expression at mRNA and protein levels at 24 h under normoxia. 15-deoxyprostaglandin J2 29-37 C-C motif chemokine ligand 2 Homo sapiens 93-98 17360948-5 2007 The light chain-mediated effect on MCP-1 production was inhibited by co-incubation with 1,3-dimethyl-2-thiourea, which also inhibited lactate dehydrogenase release, and by pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB. pyrrolidine dithiocarbamic acid 172-199 C-C motif chemokine ligand 2 Homo sapiens 35-40 17407231-1 2007 OBJECTIVE: To determine (1) whether the A(-2518)G polymorphism of CCL-2, the gene encoding monocyte chemoattractant protein-1 (MCP-1), is associated with disease, MCP-1 concentration, nephritis, or coronary artery calcification (CAC) in systemic lupus erythematosus (SLE); and (2) whether MCP-1 and homocysteine (Hcy) concentrations are correlated. Homocysteine 299-311 C-C motif chemokine ligand 2 Homo sapiens 66-71 17407231-1 2007 OBJECTIVE: To determine (1) whether the A(-2518)G polymorphism of CCL-2, the gene encoding monocyte chemoattractant protein-1 (MCP-1), is associated with disease, MCP-1 concentration, nephritis, or coronary artery calcification (CAC) in systemic lupus erythematosus (SLE); and (2) whether MCP-1 and homocysteine (Hcy) concentrations are correlated. Homocysteine 299-311 C-C motif chemokine ligand 2 Homo sapiens 127-132 17407231-1 2007 OBJECTIVE: To determine (1) whether the A(-2518)G polymorphism of CCL-2, the gene encoding monocyte chemoattractant protein-1 (MCP-1), is associated with disease, MCP-1 concentration, nephritis, or coronary artery calcification (CAC) in systemic lupus erythematosus (SLE); and (2) whether MCP-1 and homocysteine (Hcy) concentrations are correlated. Homocysteine 313-316 C-C motif chemokine ligand 2 Homo sapiens 66-71 17407231-1 2007 OBJECTIVE: To determine (1) whether the A(-2518)G polymorphism of CCL-2, the gene encoding monocyte chemoattractant protein-1 (MCP-1), is associated with disease, MCP-1 concentration, nephritis, or coronary artery calcification (CAC) in systemic lupus erythematosus (SLE); and (2) whether MCP-1 and homocysteine (Hcy) concentrations are correlated. Homocysteine 313-316 C-C motif chemokine ligand 2 Homo sapiens 127-132 17407231-10 2007 The positive correlation between MCP-1 and Hcy concentrations is consistent with the hypothesis that active inflammation and hyperhomocysteinemia are etiologically linked. Homocysteine 43-46 C-C motif chemokine ligand 2 Homo sapiens 33-38 17255125-7 2007 PPAR-gamma"s activation with 15d-PGJ2 or pioglitazone reduced basal and TNF-alpha-stimulated MCP-1 expression at mRNA and protein levels at 24 h under normoxia. Pioglitazone 41-53 C-C motif chemokine ligand 2 Homo sapiens 93-98 17255125-8 2007 MCP-1 reduction rates at basal mRNA and protein levels were slightly but significantly lower during hypoxia than normoxia (9 vs 69% and 36 vs 42%, respectively, for 15d-PGJ2, and 0 vs 34% and 12 vs 21%, respectively, for pioglitazone). 15-deoxyprostaglandin J2 165-173 C-C motif chemokine ligand 2 Homo sapiens 0-5 17255125-8 2007 MCP-1 reduction rates at basal mRNA and protein levels were slightly but significantly lower during hypoxia than normoxia (9 vs 69% and 36 vs 42%, respectively, for 15d-PGJ2, and 0 vs 34% and 12 vs 21%, respectively, for pioglitazone). Pioglitazone 221-233 C-C motif chemokine ligand 2 Homo sapiens 0-5 17255125-9 2007 Finally, a specific inhibitor for PPAR-gamma, GW9662, weakened the MCP-1-decreasing effect of 15d-PGJ2 by about 30%, under basal conditions, while it abolished the effect of pioglitazone almost completely. 2-chloro-5-nitrobenzanilide 46-52 C-C motif chemokine ligand 2 Homo sapiens 67-72 17255125-9 2007 Finally, a specific inhibitor for PPAR-gamma, GW9662, weakened the MCP-1-decreasing effect of 15d-PGJ2 by about 30%, under basal conditions, while it abolished the effect of pioglitazone almost completely. 15-deoxyprostaglandin J2 94-102 C-C motif chemokine ligand 2 Homo sapiens 67-72 17178255-9 2007 Pitavastatin, DPI, and an anti-oxidant N-acetylcysteine inhibited the LPA-induced proliferation and MCP-1 gene expression in SMCs. pitavastatin 0-12 C-C motif chemokine ligand 2 Homo sapiens 100-105 17178255-0 2007 Pitavastatin inhibits lysophosphatidic acid-induced proliferation and monocyte chemoattractant protein-1 expression in aortic smooth muscle cells by suppressing Rac-1-mediated reactive oxygen species generation. pitavastatin 0-12 C-C motif chemokine ligand 2 Homo sapiens 70-104 17307163-0 2007 Synergistic effect of PGD2 via prostanoid DP receptor on TNF-alpha-induced production of MCP-1 and IL-8 in human monocytic THP-1 cells. Prostaglandin D2 22-26 C-C motif chemokine ligand 2 Homo sapiens 89-94 17307163-3 2007 In the present study, to clarify the functional roles of prostanoid DP receptor on monocytes, we examined the effect of PGD2 on the production of monocyte chemoattractant protein (MCP)-1 and interleukin (IL)-8 from a human monocytic cell line, THP-1. Prostaglandin D2 120-124 C-C motif chemokine ligand 2 Homo sapiens 146-186 17307163-5 2007 However, activation with PGD2 in the presence of tumor necrosis factor (TNF)-alpha mediated significant production of MCP-1 and IL-8, but not the other cytokines and chemokines, in comparison to single stimulation with TNF-alpha. Prostaglandin D2 25-29 C-C motif chemokine ligand 2 Homo sapiens 118-123 17307163-6 2007 In addition, the selective prostanoid DP receptor antagonist, pinagladin ((Z)-7-[(1R,2R,3S,5S)-2-(benzothiophen-3-ylcarbonylamide)-10-norpinan-3-yl]hept-5-enoic acid) inhibited the production of MCP-1 and IL-8 upon combined stimulation with PGD2 and TNF-alpha. pinagladin 62-72 C-C motif chemokine ligand 2 Homo sapiens 195-200 17307163-6 2007 In addition, the selective prostanoid DP receptor antagonist, pinagladin ((Z)-7-[(1R,2R,3S,5S)-2-(benzothiophen-3-ylcarbonylamide)-10-norpinan-3-yl]hept-5-enoic acid) inhibited the production of MCP-1 and IL-8 upon combined stimulation with PGD2 and TNF-alpha. (Z)-7-((1R,2R,3S,5S)-2-(benzothiophen-3-ylcarbonylamide)-10-norpinan-3-yl)hept-5-enoic acid 74-165 C-C motif chemokine ligand 2 Homo sapiens 195-200 17307163-7 2007 The synergistic production of MCP-1 and IL-8 by PGD2 was mimicked by dibutyryl cAMP (db-cAMP) and was inhibited by a protein kinase A (PKA) inhibitor. Prostaglandin D2 48-52 C-C motif chemokine ligand 2 Homo sapiens 30-35 17307163-7 2007 The synergistic production of MCP-1 and IL-8 by PGD2 was mimicked by dibutyryl cAMP (db-cAMP) and was inhibited by a protein kinase A (PKA) inhibitor. Bucladesine 69-83 C-C motif chemokine ligand 2 Homo sapiens 30-35 17307163-7 2007 The synergistic production of MCP-1 and IL-8 by PGD2 was mimicked by dibutyryl cAMP (db-cAMP) and was inhibited by a protein kinase A (PKA) inhibitor. Bucladesine 85-92 C-C motif chemokine ligand 2 Homo sapiens 30-35 17178255-4 2007 In this study, we investigated whether and how pitavastatin could inhibit the LPA-induced proliferation and monocyte chemoattractant protein-1 (MCP-1) expression in cultured human aortic SMCs. pitavastatin 47-59 C-C motif chemokine ligand 2 Homo sapiens 108-142 17178255-4 2007 In this study, we investigated whether and how pitavastatin could inhibit the LPA-induced proliferation and monocyte chemoattractant protein-1 (MCP-1) expression in cultured human aortic SMCs. pitavastatin 47-59 C-C motif chemokine ligand 2 Homo sapiens 144-149 17178255-9 2007 Pitavastatin, DPI, and an anti-oxidant N-acetylcysteine inhibited the LPA-induced proliferation and MCP-1 gene expression in SMCs. diphenyleneiodonium 14-17 C-C motif chemokine ligand 2 Homo sapiens 100-105 17178255-9 2007 Pitavastatin, DPI, and an anti-oxidant N-acetylcysteine inhibited the LPA-induced proliferation and MCP-1 gene expression in SMCs. Acetylcysteine 39-55 C-C motif chemokine ligand 2 Homo sapiens 100-105 17178255-9 2007 Pitavastatin, DPI, and an anti-oxidant N-acetylcysteine inhibited the LPA-induced proliferation and MCP-1 gene expression in SMCs. lysophosphatidic acid 70-73 C-C motif chemokine ligand 2 Homo sapiens 100-105 17178255-10 2007 These results suggest that pitavastatin could block the LPA-induced proliferation and MCP-1 expression in SMCs by suppressing Rac-1-mediated NADPH oxidase-dependent ROS generation. pitavastatin 27-39 C-C motif chemokine ligand 2 Homo sapiens 86-91 17178255-10 2007 These results suggest that pitavastatin could block the LPA-induced proliferation and MCP-1 expression in SMCs by suppressing Rac-1-mediated NADPH oxidase-dependent ROS generation. lysophosphatidic acid 56-59 C-C motif chemokine ligand 2 Homo sapiens 86-91 17565837-13 2007 CONCLUSION: The serum level of MCP-1 is associated with the LH level in POCS patients. Luteinizing Hormone 60-62 C-C motif chemokine ligand 2 Homo sapiens 31-36 17424890-12 2007 PD98059 and curcunmin (AP-1 inhibitor) markedly suppressed the TNF-alpha-induced CCL2 expression, whereas the effect of SB203580 was less noted. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 C-C motif chemokine ligand 2 Homo sapiens 81-85 17339489-7 2007 The stimulatory role was confirmed by the observation that 12.5 microM H(2)O(2), a concentration found during inflammation, increased the expression of several proinflammatory NF-kappaB-dependent genes induced by TNF-alpha (e.g., IL-8, MCP-1, TLR2, and TNF-alpha). Water 71-77 C-C motif chemokine ligand 2 Homo sapiens 236-241 17322498-5 2007 RESULTS: The MCP-1 SNP c.-3813C>T exhibited trends for differences between the genotype groups in triglycerides, 2-h glucose and uric acid (P = 0.0084, 0.014, 0.027). Triglycerides 98-111 C-C motif chemokine ligand 2 Homo sapiens 13-18 17312223-6 2007 RESULTS: Exposure of AEC to sevoflurane resulted in a 50% downregulation of MCP-1 protein in the sevoflurane-LPS group when compared with non-sevoflurane- LPS cells (P < 0.05). Sevoflurane 28-39 C-C motif chemokine ligand 2 Homo sapiens 76-81 17312223-6 2007 RESULTS: Exposure of AEC to sevoflurane resulted in a 50% downregulation of MCP-1 protein in the sevoflurane-LPS group when compared with non-sevoflurane- LPS cells (P < 0.05). Sevoflurane 97-108 C-C motif chemokine ligand 2 Homo sapiens 76-81 17312223-6 2007 RESULTS: Exposure of AEC to sevoflurane resulted in a 50% downregulation of MCP-1 protein in the sevoflurane-LPS group when compared with non-sevoflurane- LPS cells (P < 0.05). Sevoflurane 97-108 C-C motif chemokine ligand 2 Homo sapiens 76-81 17380299-10 2007 MCP-1 levels were decreased with both doses of nimesulide in normal cells, whereas IL-8 levels were significantly affected only by 50 microM of nimesulide. nimesulide 47-57 C-C motif chemokine ligand 2 Homo sapiens 0-5 17158355-3 2007 METHODS AND RESULTS: Treatment of endothelial cells with anthocyanin prevented from CD40-induced proinflammatory status, measured by production of IL-6, IL-8, and monocyte chemoattractant protein-1 through inhibiting CD40-induced nuclear factor-kappaB (NF-kappaB) activation. Anthocyanins 57-68 C-C motif chemokine ligand 2 Homo sapiens 163-197 17322498-5 2007 RESULTS: The MCP-1 SNP c.-3813C>T exhibited trends for differences between the genotype groups in triglycerides, 2-h glucose and uric acid (P = 0.0084, 0.014, 0.027). Glucose 117-124 C-C motif chemokine ligand 2 Homo sapiens 13-18 17322498-5 2007 RESULTS: The MCP-1 SNP c.-3813C>T exhibited trends for differences between the genotype groups in triglycerides, 2-h glucose and uric acid (P = 0.0084, 0.014, 0.027). Uric Acid 129-138 C-C motif chemokine ligand 2 Homo sapiens 13-18 17070997-5 2007 Both rofecoxib and ibuprofen treatment increased the gene expression of the pro-inflammatory mediators, IL6 and CCL2 (chemokine C-C motif ligand 2), following tissue injury compared to the placebo treatment. rofecoxib 5-14 C-C motif chemokine ligand 2 Homo sapiens 112-116 17312179-6 2007 BMCs isolated from human corneal stroma showed a chemotactic response to MCP-1/CCL2 in the Boyden chamber assay. bmcs 0-4 C-C motif chemokine ligand 2 Homo sapiens 73-78 17312179-6 2007 BMCs isolated from human corneal stroma showed a chemotactic response to MCP-1/CCL2 in the Boyden chamber assay. bmcs 0-4 C-C motif chemokine ligand 2 Homo sapiens 79-83 17312179-9 2007 Our findings suggest that the interaction between MCP-1/CCL2 and CCR2 determines the distribution of constitutive BMCs in normal human corneal stroma. bmcs 114-118 C-C motif chemokine ligand 2 Homo sapiens 50-55 17312179-9 2007 Our findings suggest that the interaction between MCP-1/CCL2 and CCR2 determines the distribution of constitutive BMCs in normal human corneal stroma. bmcs 114-118 C-C motif chemokine ligand 2 Homo sapiens 56-60 17008880-0 2007 Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membrane. Ascorbic Acid 88-97 C-C motif chemokine ligand 2 Homo sapiens 35-40 17008880-7 2007 In addition, increased IL-8 and MCP-1 mRNA expressions were suppressed by vitamin C treatment. Ascorbic Acid 74-83 C-C motif chemokine ligand 2 Homo sapiens 32-37 17008880-9 2007 Taken together, vitamin C uptake is increased in UVB-irradiated keratinocytes through the translocation of SVCT-1 and regulates inflammatory response in the skin via the downregulation of IL-8 and MCP-1 production. Ascorbic Acid 16-25 C-C motif chemokine ligand 2 Homo sapiens 197-202 17070997-5 2007 Both rofecoxib and ibuprofen treatment increased the gene expression of the pro-inflammatory mediators, IL6 and CCL2 (chemokine C-C motif ligand 2), following tissue injury compared to the placebo treatment. rofecoxib 5-14 C-C motif chemokine ligand 2 Homo sapiens 118-146 17070997-5 2007 Both rofecoxib and ibuprofen treatment increased the gene expression of the pro-inflammatory mediators, IL6 and CCL2 (chemokine C-C motif ligand 2), following tissue injury compared to the placebo treatment. Ibuprofen 19-28 C-C motif chemokine ligand 2 Homo sapiens 112-116 17070997-5 2007 Both rofecoxib and ibuprofen treatment increased the gene expression of the pro-inflammatory mediators, IL6 and CCL2 (chemokine C-C motif ligand 2), following tissue injury compared to the placebo treatment. Ibuprofen 19-28 C-C motif chemokine ligand 2 Homo sapiens 118-146 18069417-9 2007 There was also a significantly higher frequency of the MCP-1-2518*G allele in patients presenting with LS compared to the patients without LS (p = 0.04, OR = 2.1). leucylserine 103-105 C-C motif chemokine ligand 2 Homo sapiens 55-60 17039239-3 2007 Notably, extracellular ATP displayed a complex regulation of IFN-gamma-stimulated chemokine expression, with upregulation of CC chemokine ligand 2 (CCL2), CCL5 and CXC chemokine ligand 8 (CXCL8), and suppression of the receptor CXC chemokine receptor 3 (CXCR3), CXCL9, CXCL10, and CXCL11. Adenosine Triphosphate 23-26 C-C motif chemokine ligand 2 Homo sapiens 125-146 17039239-3 2007 Notably, extracellular ATP displayed a complex regulation of IFN-gamma-stimulated chemokine expression, with upregulation of CC chemokine ligand 2 (CCL2), CCL5 and CXC chemokine ligand 8 (CXCL8), and suppression of the receptor CXC chemokine receptor 3 (CXCR3), CXCL9, CXCL10, and CXCL11. Adenosine Triphosphate 23-26 C-C motif chemokine ligand 2 Homo sapiens 148-152 17378751-4 2007 METHODS: Lipopolysaccharide (LPS)and phorbol 12-myristate 13-acetate plus ionomycin (PMA + I)-stimulated PBMC MCP-1 and IFNgamma production were determined in six extremely obese subjects (body mass index [BMI] = 62.4 +/- 8.6 kg/m(2)) before and 1 year after gastric bypass surgery and in six age-matched lean subjects (BMI = 22.7 +/- 1.4 kg/m(2)). Ionomycin 74-83 C-C motif chemokine ligand 2 Homo sapiens 110-115 18069417-9 2007 There was also a significantly higher frequency of the MCP-1-2518*G allele in patients presenting with LS compared to the patients without LS (p = 0.04, OR = 2.1). leucylserine 139-141 C-C motif chemokine ligand 2 Homo sapiens 55-60 17668557-7 2007 RESULTS: In human adipocytes, PIs and NRTIs (except amprenavir, atazanavir and abacavir) reduced lipid content, adiponectin and leptin release and increased in parallel ROS production and monocyte chemoattractant protein (MCP)-1 and interleukin (IL)-6 release. Monothiopyrophosphoric acid 30-33 C-C motif chemokine ligand 2 Homo sapiens 188-228 17239146-0 2007 Fas-mediated upregulation of vascular endothelial growth factor and monocyte chemoattractant protein-1 expression in cultured dermal fibroblasts: role in the inflammatory response. ammonium ferrous sulfate 0-3 C-C motif chemokine ligand 2 Homo sapiens 68-102 17239146-10 2007 A pan-caspase inhibitor (Z-VAD-FMK) significantly inhibited VEGF and MCP-1 expression. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone 25-34 C-C motif chemokine ligand 2 Homo sapiens 69-74 17237435-6 2007 Prednisolone dose-dependently inhibited the LPS-induced release of cytokines (TNF-alpha and IL-6) and chemokines (IL-8 and MCP-1), while enhancing the release of the anti-inflammatory cytokine IL-10. Prednisolone 0-12 C-C motif chemokine ligand 2 Homo sapiens 123-128 16740681-0 2007 Up regulation of monocyte chemoattractant protein-1 expression in anti-citrulline antibody and immunoglobulin M rheumatoid factor positive subjects precedes onset of inflammatory response and development of overt rheumatoid arthritis. Citrulline 71-81 C-C motif chemokine ligand 2 Homo sapiens 17-51 17277122-7 2007 Human immature dendritic cells (DCs) cultured in the presence of c-di-GMP showed increased expression of costimulatory molecules CD80/CD86 and maturation marker CD83, increased MHC class II and cytokines and chemokines such as IL-12, IFN-gamma, IL-8, MCP-1, IFN-gamma-inducible protein 10, and RANTES, and altered expression of chemokine receptors including CCR1, CCR7, and CXCR4. bis(3',5')-cyclic diguanylic acid 65-73 C-C motif chemokine ligand 2 Homo sapiens 251-256 17184586-1 2007 AIM: To examine the inhibitive effects of triptolide on the expression of IL-8, monocyte chemotactic protein (MCP)-1, and matrix metalloproteinases (MMP)-3 in subepithelial myofibroblasts (SEMF) stimulated with IL-1beta. triptolide 42-52 C-C motif chemokine ligand 2 Homo sapiens 80-116 17668557-9 2007 In PMA-THP-1 macrophages, all PIs, but no NRTI, increased macrophage inflammatory protein-1 alpha and MCP-1 release. Monothiopyrophosphoric acid 30-33 C-C motif chemokine ligand 2 Homo sapiens 102-107 16574124-8 2007 DHEA at the above mention concentration also inhibited the mRNA expression of MCP-1 and IL-8 in basal conditions but not in TNF-alpha-stimulated conditions. Dehydroepiandrosterone 0-4 C-C motif chemokine ligand 2 Homo sapiens 78-83 17261959-7 2007 The effect of CRP on VCAM-1 expression in HUVECs and supernatant levels of MCP-1 and IL-6 were significantly suppressed by 25 micromol/L simvastatin with stepwise increased suppression as simvastatin dose increased to 50, 75, and 100 micromol/L (all P < 0.0001). Simvastatin 137-148 C-C motif chemokine ligand 2 Homo sapiens 75-80 17046269-6 2007 Optimization of the 1H-indazole inhibitors with respect to the in vitro inhibition of monocyte chemotaxis induced by MCP-1 was carried out. Indazoles 20-31 C-C motif chemokine ligand 2 Homo sapiens 117-122 17390111-5 2007 CCL2 production was assessed in paraffin embedded tumour samples by immunohistochemistry. Paraffin 32-40 C-C motif chemokine ligand 2 Homo sapiens 0-4 18997280-5 2007 Here, we report that after differentiating THP-1 cells to macrophages, ritonavir treatment (10 microg/mL) significantly increases expression of proinflammatory cytokines, IL-6, MCP-1 and IL-8, at both mRNA and protein levels. Ritonavir 71-80 C-C motif chemokine ligand 2 Homo sapiens 177-182 17243915-4 2007 The aim of this study was to investigate whether plasma concentrations of interleukin-6, interleukin-8, C-reactive protein, and monocyte chemoattractant protein-1 are increased with higher plasma homocysteine concentrations and whether decreasing homocysteine by vitamin supplementation decreases the concentration of these markers. Homocysteine 196-208 C-C motif chemokine ligand 2 Homo sapiens 128-162 18292825-3 2007 In this study we compared serum MCP-1 concentrations between pregnant women with normal glucose tolerance (NGT), gestational diabetes mellitus (GDM) and non-pregnant healthy women. Glucose 88-95 C-C motif chemokine ligand 2 Homo sapiens 32-37 18292825-9 2007 Multiple regression analysis revealed that MCP1 concentrations were significantly predicted only by plasma glucose ( beta=0.3489, p=0.00004). Glucose 107-114 C-C motif chemokine ligand 2 Homo sapiens 43-47 17261959-7 2007 The effect of CRP on VCAM-1 expression in HUVECs and supernatant levels of MCP-1 and IL-6 were significantly suppressed by 25 micromol/L simvastatin with stepwise increased suppression as simvastatin dose increased to 50, 75, and 100 micromol/L (all P < 0.0001). Simvastatin 188-199 C-C motif chemokine ligand 2 Homo sapiens 75-80 17159372-6 2007 Plasminogen treatment reversed the RCS or NAPlr-induced decrease of PECAM-1 expression and increase of MCP-1 expression. naplr 42-47 C-C motif chemokine ligand 2 Homo sapiens 103-108 17408061-0 2007 Nifedipine, a calcium-channel blocker, inhibits advanced glycation end-product-induced expression of monocyte chemoattractant protein-1 in human cultured mesangial cells. Nifedipine 0-10 C-C motif chemokine ligand 2 Homo sapiens 101-135 17408061-2 2007 This study investigated whether nifedipine, a widely used anti-hypertensive drug, suppresses expression of monocyte chemoattractant protein-1 (MCP-1), a chemokine that mediates the recruitment of monocytes to inflammatory sites, in AGE-exposed human cultured mesangial cells. Nifedipine 32-42 C-C motif chemokine ligand 2 Homo sapiens 107-141 17408061-2 2007 This study investigated whether nifedipine, a widely used anti-hypertensive drug, suppresses expression of monocyte chemoattractant protein-1 (MCP-1), a chemokine that mediates the recruitment of monocytes to inflammatory sites, in AGE-exposed human cultured mesangial cells. Nifedipine 32-42 C-C motif chemokine ligand 2 Homo sapiens 143-148 17408061-4 2007 AGEs significantly increased both MCP-1 mRNA expression and protein production in mesangial cells; this increase was blocked by both nifedipine and diphenylene iodonium. Nifedipine 133-143 C-C motif chemokine ligand 2 Homo sapiens 34-39 17408061-4 2007 AGEs significantly increased both MCP-1 mRNA expression and protein production in mesangial cells; this increase was blocked by both nifedipine and diphenylene iodonium. diphenyleneiodonium 148-168 C-C motif chemokine ligand 2 Homo sapiens 34-39 17408061-5 2007 These results suggest that nifedipine could play a protective role against early diabetic nephropathy by suppressing MCP-1 overexpression via blockade of AGE signalling in mesangial cells. Nifedipine 27-37 C-C motif chemokine ligand 2 Homo sapiens 117-122 17191021-0 2007 Resveratrol, a polyphenolic phytostilbene, inhibits endothelial monocyte chemotactic protein-1 synthesis and secretion. Resveratrol 0-11 C-C motif chemokine ligand 2 Homo sapiens 64-94 17191021-0 2007 Resveratrol, a polyphenolic phytostilbene, inhibits endothelial monocyte chemotactic protein-1 synthesis and secretion. polyphenolic phytostilbene 15-41 C-C motif chemokine ligand 2 Homo sapiens 64-94 17191021-2 2007 We investigated the effect of resveratrol on the expression of the atherogenic chemokine, monocyte chemotactic protein-1 (MCP-1). Resveratrol 30-41 C-C motif chemokine ligand 2 Homo sapiens 90-120 17191021-2 2007 We investigated the effect of resveratrol on the expression of the atherogenic chemokine, monocyte chemotactic protein-1 (MCP-1). Resveratrol 30-41 C-C motif chemokine ligand 2 Homo sapiens 122-127 17191021-5 2007 RESULTS: Resveratrol (1-100 microM) dose-dependently inhibited IL-1beta-stimulated MCP-1 secretion, with approximately 45% inhibition at 50 microM resveratrol. Resveratrol 9-20 C-C motif chemokine ligand 2 Homo sapiens 83-88 17191021-7 2007 Resveratrol also significantly inhibited MCP-1 gene expression in a Gi-protein-dependent but NO-independent manner. Resveratrol 0-11 C-C motif chemokine ligand 2 Homo sapiens 41-46 17191021-8 2007 While resveratrol had no effect on MCP-1 mRNA degradation, it inhibited MCP-1 promoter activity and reduced nuclear factor kappaB and activator protein-1 binding activity induced by IL-1beta. Resveratrol 6-17 C-C motif chemokine ligand 2 Homo sapiens 72-77 17191021-10 2007 CONCLUSION: These data demonstrate an inhibitory effect of resveratrol on MCP-1 synthesis and secretion, mediated via distinct signaling pathways. Resveratrol 59-70 C-C motif chemokine ligand 2 Homo sapiens 74-79 17191021-11 2007 The inhibition of MCP-1 may represent a novel cardioprotective mechanism of resveratrol. Resveratrol 76-87 C-C motif chemokine ligand 2 Homo sapiens 18-23 17148667-9 2006 The intracellular calcium chelator BAPTA-AM blocked resistin-induced NF-kappaB activation and monocyte chemoattractant protein-1 expression. Calcium 18-25 C-C motif chemokine ligand 2 Homo sapiens 94-128 17994445-0 2007 Effects of long-term pravastatin treatment on serum and urinary monocyte chemoattractant protein-1 levels and renal function in type 2 diabetic patients with normoalbuminuria. Pravastatin 21-32 C-C motif chemokine ligand 2 Homo sapiens 64-98 17994445-4 2007 Interestingly, serum MCP-1 levels were significantly lower in the hyperlipidemic patients treated with pravastatin than in the non-hyperlipidemic patients. Pravastatin 103-114 C-C motif chemokine ligand 2 Homo sapiens 21-26 17156455-0 2006 Morphine stimulates CCL2 production by human neurons. Morphine 0-8 C-C motif chemokine ligand 2 Homo sapiens 20-24 17156455-3 2006 We hypothesized that morphine may alter expression of CCL2 by human neurons. Morphine 21-29 C-C motif chemokine ligand 2 Homo sapiens 54-58 17156455-7 2006 beta-funaltrexamine (beta-FNA) was used to block mu-opioid receptor (MOR)s. RESULTS: Morphine upregulated CCL2 mRNA and protein in neuronal cultures in a concentration- and time-dependent fashion, but had no effect on CCL2 production in astrocyte or microglial cell cultures. beta-funaltrexamine 0-19 C-C motif chemokine ligand 2 Homo sapiens 106-110 17156455-7 2006 beta-funaltrexamine (beta-FNA) was used to block mu-opioid receptor (MOR)s. RESULTS: Morphine upregulated CCL2 mRNA and protein in neuronal cultures in a concentration- and time-dependent fashion, but had no effect on CCL2 production in astrocyte or microglial cell cultures. beta-funaltrexamine 21-29 C-C motif chemokine ligand 2 Homo sapiens 106-110 17156455-7 2006 beta-funaltrexamine (beta-FNA) was used to block mu-opioid receptor (MOR)s. RESULTS: Morphine upregulated CCL2 mRNA and protein in neuronal cultures in a concentration- and time-dependent fashion, but had no effect on CCL2 production in astrocyte or microglial cell cultures. Morphine 85-93 C-C motif chemokine ligand 2 Homo sapiens 106-110 17156455-7 2006 beta-funaltrexamine (beta-FNA) was used to block mu-opioid receptor (MOR)s. RESULTS: Morphine upregulated CCL2 mRNA and protein in neuronal cultures in a concentration- and time-dependent fashion, but had no effect on CCL2 production in astrocyte or microglial cell cultures. Morphine 85-93 C-C motif chemokine ligand 2 Homo sapiens 218-222 17156455-8 2006 Immunocytochemical analysis also demonstrated CCL2 production in morphine-stimulated neuronal cultures. Morphine 65-73 C-C motif chemokine ligand 2 Homo sapiens 46-50 17156455-10 2006 CONCLUSION: Morphine stimulates CCL2 production by human neurons via a MOR-related mechanism. Morphine 12-20 C-C motif chemokine ligand 2 Homo sapiens 32-36 17148667-9 2006 The intracellular calcium chelator BAPTA-AM blocked resistin-induced NF-kappaB activation and monocyte chemoattractant protein-1 expression. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 35-43 C-C motif chemokine ligand 2 Homo sapiens 94-128 16730843-11 2006 In vitro studies demonstrated that glycated albumin or high glucose induces NF-kappaB activation followed by up-regulation of MCP-1 promoter activity and protein production in glial cells. Glucose 60-67 C-C motif chemokine ligand 2 Homo sapiens 126-131 17050345-7 2006 Significant inductions of IL-1beta, TNF-alpha, and Cox-1 and Cox-2 mRNA were observed following exposure to > or =50 ppm acetaldehyde for 4 h. IL-6 and MCP-1 were also induced following a 4-h exposure to 500 ppm acetaldehyde. Acetaldehyde 124-136 C-C motif chemokine ligand 2 Homo sapiens 155-160 16966829-8 2006 Multiple linear regression analysis showed that serum creatinine and urinary adiponectin levels were independently associated with serum adiponectin levels (r(2) = 0.522), and that serum creatinine, urinary NAG, urinary MCP-1, and serum adiponectin levels were independent determinants of urinary adiponectin levels (r(2) = 0.851). Creatinine 54-64 C-C motif chemokine ligand 2 Homo sapiens 220-225 17050345-7 2006 Significant inductions of IL-1beta, TNF-alpha, and Cox-1 and Cox-2 mRNA were observed following exposure to > or =50 ppm acetaldehyde for 4 h. IL-6 and MCP-1 were also induced following a 4-h exposure to 500 ppm acetaldehyde. Acetaldehyde 215-227 C-C motif chemokine ligand 2 Homo sapiens 155-160 17045925-9 2006 These data indicate that Hcy-induced ROS upregulate the expression and translocation of Ref-1 via NADPH oxidase, and then Ref-1 increases NF-kappaB activity and MCP-1 secretion in human monocytes/macrophages, which may accelerate the development of atherosclerosis. Homocysteine 25-28 C-C motif chemokine ligand 2 Homo sapiens 161-166 17045925-9 2006 These data indicate that Hcy-induced ROS upregulate the expression and translocation of Ref-1 via NADPH oxidase, and then Ref-1 increases NF-kappaB activity and MCP-1 secretion in human monocytes/macrophages, which may accelerate the development of atherosclerosis. Reactive Oxygen Species 37-40 C-C motif chemokine ligand 2 Homo sapiens 161-166 17045925-2 2006 We have previously shown that homocysteine can induce monocyte chemoattractant protein-1 (MCP-1) secretion via reactive oxygen species (ROS) in human monocytes in vitro. Homocysteine 30-42 C-C motif chemokine ligand 2 Homo sapiens 54-88 16781696-8 2006 After simvastatin treatment, the mRNA expressions of MCP-1 and CCR2 were significantly reduced in one and a half months and decreased to the lowest levels in three months. Simvastatin 6-17 C-C motif chemokine ligand 2 Homo sapiens 53-58 17045925-2 2006 We have previously shown that homocysteine can induce monocyte chemoattractant protein-1 (MCP-1) secretion via reactive oxygen species (ROS) in human monocytes in vitro. Homocysteine 30-42 C-C motif chemokine ligand 2 Homo sapiens 90-95 17045925-2 2006 We have previously shown that homocysteine can induce monocyte chemoattractant protein-1 (MCP-1) secretion via reactive oxygen species (ROS) in human monocytes in vitro. Reactive Oxygen Species 111-134 C-C motif chemokine ligand 2 Homo sapiens 54-88 17045925-2 2006 We have previously shown that homocysteine can induce monocyte chemoattractant protein-1 (MCP-1) secretion via reactive oxygen species (ROS) in human monocytes in vitro. Reactive Oxygen Species 111-134 C-C motif chemokine ligand 2 Homo sapiens 90-95 17045925-2 2006 We have previously shown that homocysteine can induce monocyte chemoattractant protein-1 (MCP-1) secretion via reactive oxygen species (ROS) in human monocytes in vitro. Reactive Oxygen Species 136-139 C-C motif chemokine ligand 2 Homo sapiens 54-88 17045925-2 2006 We have previously shown that homocysteine can induce monocyte chemoattractant protein-1 (MCP-1) secretion via reactive oxygen species (ROS) in human monocytes in vitro. Reactive Oxygen Species 136-139 C-C motif chemokine ligand 2 Homo sapiens 90-95 16794257-3 2006 Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells. Quercetin 18-27 C-C motif chemokine ligand 2 Homo sapiens 107-147 16794257-3 2006 Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells. Quercetin 18-27 C-C motif chemokine ligand 2 Homo sapiens 161-165 16794257-3 2006 Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 58-66 C-C motif chemokine ligand 2 Homo sapiens 107-147 16794257-3 2006 Pretreatment with quercetin and the PI 3-kinase inhibitor LY294002 each reduced TNF-alpha-induced IL-8 and monocyte chemoattractant protein (MCP)-1 (also called CCL2) expression in cultured human airway epithelial cells. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 58-66 C-C motif chemokine ligand 2 Homo sapiens 161-165 17045117-7 2006 Serum MCP-1 levels were positively correlated with HbA1c and plasma fasting glucose levels. Glucose 76-83 C-C motif chemokine ligand 2 Homo sapiens 6-11 17426779-0 2006 Polymorphisms in CCL2&CCL5 chemokines/chemokine receptors genes and their association with diseases. Adenosine Monophosphate 22-25 C-C motif chemokine ligand 2 Homo sapiens 17-21 16939517-7 2006 Glutathione in FW further decreased CCL2/MCP-1 in a dose-dependent manner. Glutathione 0-11 C-C motif chemokine ligand 2 Homo sapiens 36-40 16939517-7 2006 Glutathione in FW further decreased CCL2/MCP-1 in a dose-dependent manner. Glutathione 0-11 C-C motif chemokine ligand 2 Homo sapiens 41-46 16931790-5 2006 Using the UPR inducing agent tunicamycin and selective siRNA targeting of the ATF4 and XBP1 branches of the UPR, we demonstrate that these transcription factors are essential mediators of IL8, IL6, and MCP1 expression in human aortic ECs required for maximal inflammatory gene expression in the basal state and after oxPAPC treatment. Tunicamycin 29-40 C-C motif chemokine ligand 2 Homo sapiens 202-206 16931790-5 2006 Using the UPR inducing agent tunicamycin and selective siRNA targeting of the ATF4 and XBP1 branches of the UPR, we demonstrate that these transcription factors are essential mediators of IL8, IL6, and MCP1 expression in human aortic ECs required for maximal inflammatory gene expression in the basal state and after oxPAPC treatment. oxpapc 317-323 C-C motif chemokine ligand 2 Homo sapiens 202-206 16781696-9 2006 CONCLUSIONS: Simvastatin decreased the expressions of MCP-1 and CCR2 in post-kidney transplant patients with hyperlipidemia. Simvastatin 13-24 C-C motif chemokine ligand 2 Homo sapiens 54-59 17067316-7 2006 In contrast, inhibitors of nuclear factor kappa B (NF-kappaB) completely blocked CCL2 production in MLMC and BMMC but not in LAD 2 mast cells. mlmc 100-104 C-C motif chemokine ligand 2 Homo sapiens 81-85 17067316-7 2006 In contrast, inhibitors of nuclear factor kappa B (NF-kappaB) completely blocked CCL2 production in MLMC and BMMC but not in LAD 2 mast cells. bmmc 109-113 C-C motif chemokine ligand 2 Homo sapiens 81-85 17067316-8 2006 Pertussis toxin and U0126, which, respectively, inhibit Galphai, extracellular signal-regulated kinase (ERK) phosphorylation substantially inhibited Pam3Cys-induced CCL2 generation in LAD 2 mast cells but had little or no effect on chemokine generation in MLMC and BMMC. U 0126 20-25 C-C motif chemokine ligand 2 Homo sapiens 165-169 16795034-0 2006 Lysophospholipids increase IL-8 and MCP-1 expressions in human umbilical cord vein endothelial cells through an IL-1-dependent mechanism. Lysophospholipids 0-17 C-C motif chemokine ligand 2 Homo sapiens 36-41 17295000-5 2006 Azelnidipine, 10 nmol/l, was found to inhibit the TNF-alpha-induced upregulation of monocyte chemoattractant protein-1 mRNA levels in human umbilical vein endothelial cells significantly. azelnidipine 0-12 C-C motif chemokine ligand 2 Homo sapiens 84-118 17295000-6 2006 Furthermore, azelnidipine suppressed TNF-alpha-induced monocyte chemoattractant protein-1 production by human umbilical vein endothelial cells. azelnidipine 13-25 C-C motif chemokine ligand 2 Homo sapiens 55-89 17295000-0 2006 Azelnidipine, a new long-acting calcium-channel blocker, inhibits tumour necrosis factor-alpha-induced monocyte chemoattractant protein-1 expression in endothelial cells. azelnidipine 0-12 C-C motif chemokine ligand 2 Homo sapiens 103-137 17295000-3 2006 The aim of this study was to determine whether azelnidipine could suppress the expression of monocyte chemoattractant protein-1, a principal chemokine which mediates the recruitment of monocytes to the vasculature, in tumour necrosis factor (TNF)-alpha-exposed human umbilical vein endothelial cells. azelnidipine 47-59 C-C motif chemokine ligand 2 Homo sapiens 93-127 17295000-7 2006 This study demonstrates a novel beneficial aspect of azelnidipine, whereby azelnidipine could play a protective role against atherosclerosis by suppressing monocyte chemoattractant protein-1 overexpression in endothelial cells. azelnidipine 53-65 C-C motif chemokine ligand 2 Homo sapiens 156-190 17295000-7 2006 This study demonstrates a novel beneficial aspect of azelnidipine, whereby azelnidipine could play a protective role against atherosclerosis by suppressing monocyte chemoattractant protein-1 overexpression in endothelial cells. azelnidipine 75-87 C-C motif chemokine ligand 2 Homo sapiens 156-190 16924534-5 2006 In contrast, PGD(2) induced a marked stimulation of IL-6 and MCP-1 expression; with IL-6, this was rapid, the mRNA level increasing by >50-fold by 1 h. The rise in mRNA was accompanied by an increase in IL-6 and MCP-1 release (up to 100- and 6.5-fold, respectively). Prostaglandin D2 13-19 C-C motif chemokine ligand 2 Homo sapiens 215-220 17072102-7 2006 After 48 h of incubation (under the influence of synthesized aldosterone), CV-11974 and spironolactone significantly reduced the Ang II-enhanced production of MCP-1 and TNF-alpha, whereas PD-123319 also had no effect. Spironolactone 88-102 C-C motif chemokine ligand 2 Homo sapiens 159-164 17006379-0 2006 Estrogen and raloxifene inhibit the monocytic chemoattractant protein-1-induced migration of human monocytic cells via nongenomic estrogen receptor alpha. Raloxifene Hydrochloride 13-23 C-C motif chemokine ligand 2 Homo sapiens 36-71 17006379-5 2006 THP-1 cells were exposed to E2 or raloxifene in the presence of monocytic chemoattractant protein-1 (MCP-1), a major chemoattractant for monocytes. Raloxifene Hydrochloride 34-44 C-C motif chemokine ligand 2 Homo sapiens 64-99 17006379-5 2006 THP-1 cells were exposed to E2 or raloxifene in the presence of monocytic chemoattractant protein-1 (MCP-1), a major chemoattractant for monocytes. Raloxifene Hydrochloride 34-44 C-C motif chemokine ligand 2 Homo sapiens 101-106 17006379-9 2006 The addition of E2 or raloxifene significantly inhibited the MCP-1-induced migration for 90 minutes. Raloxifene Hydrochloride 22-32 C-C motif chemokine ligand 2 Homo sapiens 61-66 16924534-0 2006 Prostaglandin D2 and J2-series (PGJ2, Delta12-PGJ2) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytes. Prostaglandin D2 0-16 C-C motif chemokine ligand 2 Homo sapiens 86-91 16924534-0 2006 Prostaglandin D2 and J2-series (PGJ2, Delta12-PGJ2) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytes. Prostaglandins 52-66 C-C motif chemokine ligand 2 Homo sapiens 86-91 16924534-5 2006 In contrast, PGD(2) induced a marked stimulation of IL-6 and MCP-1 expression; with IL-6, this was rapid, the mRNA level increasing by >50-fold by 1 h. The rise in mRNA was accompanied by an increase in IL-6 and MCP-1 release (up to 100- and 6.5-fold, respectively). Prostaglandin D2 13-19 C-C motif chemokine ligand 2 Homo sapiens 61-66 16621921-8 2006 In addition, CCL2 was more abundant in patients who experienced two or more relapses during the first year compared with those who endured sustained remission (127 +/- 82 vs 11 +/- 5.5, P = 0.0233) and correlated with the cumulated prednisolone dose (R = 0.533, P = 0.0024). Prednisolone 232-244 C-C motif chemokine ligand 2 Homo sapiens 13-17 17080224-7 2006 In the aspirin group we found significantly lower levels of TNFa and MCP-1 after one year; 1.00 versus 1.16 pg/ml (p < 0.001) and 245 versus 261 pg/ml (p < 0.001), respectively. Aspirin 7-14 C-C motif chemokine ligand 2 Homo sapiens 69-74 16919250-9 2006 We conclude that human NT2-N neurons release IL-8 and MCP-1 during 21 h of reoxygenation after 3 h of hypoxia. nt2-n 23-28 C-C motif chemokine ligand 2 Homo sapiens 54-59 17029470-2 2006 The CCl2 parent molecule was generated in a molecular beam by pyrolysis of CHCl3, and both CCl2 and the CCl photofragment were detected by laser fluorescence excitation. Chloroform 75-80 C-C motif chemokine ligand 2 Homo sapiens 4-8 17029470-2 2006 The CCl2 parent molecule was generated in a molecular beam by pyrolysis of CHCl3, and both CCl2 and the CCl photofragment were detected by laser fluorescence excitation. Cefaclor 4-7 C-C motif chemokine ligand 2 Homo sapiens 91-95 17068620-10 2006 Univariate analysis revealed that serum MCP-1 levels were significantly and positively correlated with BMI (r = 0.350, P = 0.001), LH(r = 0.262, P = 0.016), TG (r = 0.480, P = 0.000) and ApoB (r = 0.289, P =0.008); but significantly and negatively correlated with the ratio of ApoA/ ApoB (r = -0.282, P = 0.009). Triglycerides 157-159 C-C motif chemokine ligand 2 Homo sapiens 40-45 16988133-6 2006 Multinomial logistic regression models were used to determine whether vitamin A-supplemented children had different categorical values of MCP-1 compared with children in the placebo group. Vitamin A 70-79 C-C motif chemokine ligand 2 Homo sapiens 138-143 17178597-4 2006 Here, we review the current knowledge on MCP-1 and its regulation by high glucose level in vascular cells involved in diabetes-induced accelerated atherosclerosis. Glucose 74-81 C-C motif chemokine ligand 2 Homo sapiens 41-46 17178597-5 2006 The signalling pathways involved in MCP-1 modulation by high glucose, the proximal signalling events that stimulate downstream effects and the role of this chemokine in the pathophysiology of diabetes and its complications, are discussed. Glucose 61-68 C-C motif chemokine ligand 2 Homo sapiens 36-41 16763009-12 2006 The tissue concentration of MCP-1 corresponded to increased Mvarphi infiltration and was significantly higher in women with SMM and IMM than that in women with SSM (P<0.05 for each). smm 124-127 C-C motif chemokine ligand 2 Homo sapiens 28-33 16988133-8 2006 Overall, children who received the vitamin A supplement had reduced fecal concentrations of MCP-1 compared with children in the placebo group (median pg/mg protein +/- interquartile range: 284.88 +/- 885.35 vs. 403.39 +/- 913.16; odds ratio 0.64, 95% CI 0.42-97, P = 0.03). Vitamin A 35-44 C-C motif chemokine ligand 2 Homo sapiens 92-97 16988133-0 2006 Vitamin A supplementation reduces the monocyte chemoattractant protein-1 intestinal immune response of Mexican children. Vitamin A 0-9 C-C motif chemokine ligand 2 Homo sapiens 38-72 16988133-9 2006 Vitamin A supplemented children infected with enteropathogenic Escherichia coli (EPEC) had reduced MCP-1 levels (odds ratio = 0.38, 95% CI 0.18-0.80) compared with children in the placebo group. Vitamin A 0-9 C-C motif chemokine ligand 2 Homo sapiens 99-104 16988133-10 2006 Among children not infected with Ascaris lumbricoides vitamin A supplemented children had reduced MCP-1 levels (OR = 0.62, 95% CI 0.41-0.94). Vitamin A 54-63 C-C motif chemokine ligand 2 Homo sapiens 98-103 16988133-11 2006 These findings suggest that vitamin A has an anti-inflammatory effect in the gastrointestinal tract by reducing MCP-1 concentrations. Vitamin A 28-37 C-C motif chemokine ligand 2 Homo sapiens 112-117 16321392-7 2006 Messenger RNA analysis revealed that expression of the chemokines MCP-1, MIP-1alpha and MIP-1beta, as well as the chemokine receptors CCR1, CCR2, CCR4 and CCR5, was decreased by simvastatin, both in ECs and macrophages. Simvastatin 178-189 C-C motif chemokine ligand 2 Homo sapiens 66-71 17062919-7 2006 After the treatment with indapamide for 4 weeks, MCP-1, MIP-1alpha and sP-selectin slightly decreased, but not statistically significant (P>0.05). Indapamide 25-35 C-C motif chemokine ligand 2 Homo sapiens 49-54 16597919-9 2006 We previously showed that the CGRP inhibitory effect was mediated by elevated intracellular cAMP and show here that analogs of cAMP, 8-bromoadenosine 3",5"-cyclic monophosphothioate and the Sp isomer of adenosine 3",5"-cyclic monophosphothioate, mimicked the CGRP suppressive effect on IL-1beta-induced ROS formation, NF-kappaB activation, and MCP-1 secretion. 8-bromoadenosine 3",5"-cyclic monophosphothioate 133-181 C-C motif chemokine ligand 2 Homo sapiens 344-349 16597919-9 2006 We previously showed that the CGRP inhibitory effect was mediated by elevated intracellular cAMP and show here that analogs of cAMP, 8-bromoadenosine 3",5"-cyclic monophosphothioate and the Sp isomer of adenosine 3",5"-cyclic monophosphothioate, mimicked the CGRP suppressive effect on IL-1beta-induced ROS formation, NF-kappaB activation, and MCP-1 secretion. TFF2 protein, human 190-192 C-C motif chemokine ligand 2 Homo sapiens 344-349 16597919-10 2006 Thus increased endogenous CGRP secretion in lung inflammatory disease might eliminate the excessive response by elevating the cAMP level through inhibiting the ROS-NF-kappaB-MCP-1 pathway. Cyclic AMP 126-130 C-C motif chemokine ligand 2 Homo sapiens 174-179 16597919-10 2006 Thus increased endogenous CGRP secretion in lung inflammatory disease might eliminate the excessive response by elevating the cAMP level through inhibiting the ROS-NF-kappaB-MCP-1 pathway. Reactive Oxygen Species 160-163 C-C motif chemokine ligand 2 Homo sapiens 174-179 16986842-0 2006 Kinetics of the reactions of O(3P) with CCl2=CH2, (Z)-CHCl=CHCl, and CCl2=CCl2: a temperature dependence study. o(3p) 29-34 C-C motif chemokine ligand 2 Homo sapiens 40-44 16986842-0 2006 Kinetics of the reactions of O(3P) with CCl2=CH2, (Z)-CHCl=CHCl, and CCl2=CCl2: a temperature dependence study. o(3p) 29-34 C-C motif chemokine ligand 2 Homo sapiens 69-73 16986842-0 2006 Kinetics of the reactions of O(3P) with CCl2=CH2, (Z)-CHCl=CHCl, and CCl2=CCl2: a temperature dependence study. o(3p) 29-34 C-C motif chemokine ligand 2 Homo sapiens 69-73 16986842-0 2006 Kinetics of the reactions of O(3P) with CCl2=CH2, (Z)-CHCl=CHCl, and CCl2=CCl2: a temperature dependence study. Methylene 45-48 C-C motif chemokine ligand 2 Homo sapiens 40-44 16936090-6 2006 Triptolide and dexamethasone each inhibited in a concentration-dependent manner the LPS-induced release of IL-6, G-CSF, MCP-1, and IL-8 by corneal fibroblasts. triptolide 0-10 C-C motif chemokine ligand 2 Homo sapiens 120-125 16534530-11 2006 The levels of MCP-1 were positively related to the levels of CRP (P<0.007) or interleukin-6 (IL-6) (P<0.0001), and negatively related to the levels of HDL-cholesterol (P<0.01). Cholesterol 161-172 C-C motif chemokine ligand 2 Homo sapiens 14-19 16534530-13 2006 DISCUSSION: Our data demonstrated that the circulating levels of MCP-1 and IL-8 are related to obesity-related parameters such as BMI, waist circumference, CRP, IL-6, HOMA and HDL-cholesterol. Cholesterol 180-191 C-C motif chemokine ligand 2 Homo sapiens 65-70 16925768-0 2006 Oxalate ions and calcium oxalate crystal-induced up-regulation of osteopontin and monocyte chemoattractant protein-1 in renal fibroblasts. Oxalates 0-7 C-C motif chemokine ligand 2 Homo sapiens 82-116 16925768-0 2006 Oxalate ions and calcium oxalate crystal-induced up-regulation of osteopontin and monocyte chemoattractant protein-1 in renal fibroblasts. Calcium Oxalate 17-32 C-C motif chemokine ligand 2 Homo sapiens 82-116 17375405-3 2006 Glucose, glucose metabolites and AGEs alter endothelial cell functions, induce adhesion molecule overexpression (ICAM-1, VCAM), cytokine release (IL-6, MCP-1) and tissue factor production. Glucose 0-7 C-C motif chemokine ligand 2 Homo sapiens 152-157 17375405-3 2006 Glucose, glucose metabolites and AGEs alter endothelial cell functions, induce adhesion molecule overexpression (ICAM-1, VCAM), cytokine release (IL-6, MCP-1) and tissue factor production. Glucose 9-16 C-C motif chemokine ligand 2 Homo sapiens 152-157 16936090-6 2006 Triptolide and dexamethasone each inhibited in a concentration-dependent manner the LPS-induced release of IL-6, G-CSF, MCP-1, and IL-8 by corneal fibroblasts. Dexamethasone 15-28 C-C motif chemokine ligand 2 Homo sapiens 120-125 16936090-10 2006 CONCLUSIONS: Triptolide inhibits the LPS-induced expression of IL-6, chemokines (G-CSF, MCP-1, IL-8), and ICAM-1 in cultured human corneal fibroblasts. triptolide 13-23 C-C motif chemokine ligand 2 Homo sapiens 88-93 16915039-7 2006 Azelnidipine also reduced local oxidative stress and monocyte chemoattractant protein 1 (MCP-1) expression. azelnidipine 0-12 C-C motif chemokine ligand 2 Homo sapiens 53-87 16915039-7 2006 Azelnidipine also reduced local oxidative stress and monocyte chemoattractant protein 1 (MCP-1) expression. azelnidipine 0-12 C-C motif chemokine ligand 2 Homo sapiens 89-94 16915039-9 2006 Azelnidipine also reduced MCP-1-induced proliferation/migration of vascular smooth muscle cells in vitro. azelnidipine 0-12 C-C motif chemokine ligand 2 Homo sapiens 26-31 16915039-10 2006 CONCLUSIONS: This study demonstrated for the first time that azelnidipine attenuates in-stent neointimal formation associated with the reduced expression of MCP-1 and smooth muscle proliferation/migration in the neointima. azelnidipine 61-73 C-C motif chemokine ligand 2 Homo sapiens 157-162 17064581-9 2006 HCY of different concentration of 0.25 mmol/L increased the protein expression of TNF-alpha, IL-6, MCP-1, and ICAM-1 significantly; however, the expression levels of TNF-alpha, IL-6, MCP-1, and ICAM-1 of the 0.25 mmol/L HCY-treated HUVECs that were pretreated by SIM of the concentration of 10 micromol/L for 1 hour were, 0.23 +/- 0.05, 0.14 +/- 0.03, 0.13 +/- 0.04, and 0.21 +/- 0.07 respectively, not significantly different from those at the time of 0 hour (all P > 0.05). Homocysteine 0-3 C-C motif chemokine ligand 2 Homo sapiens 99-104 16831471-2 2006 Tat and/or morphine additively increased the proportion of CCL2 immunoreactive astroglia. Morphine 11-19 C-C motif chemokine ligand 2 Homo sapiens 59-63 17064581-9 2006 HCY of different concentration of 0.25 mmol/L increased the protein expression of TNF-alpha, IL-6, MCP-1, and ICAM-1 significantly; however, the expression levels of TNF-alpha, IL-6, MCP-1, and ICAM-1 of the 0.25 mmol/L HCY-treated HUVECs that were pretreated by SIM of the concentration of 10 micromol/L for 1 hour were, 0.23 +/- 0.05, 0.14 +/- 0.03, 0.13 +/- 0.04, and 0.21 +/- 0.07 respectively, not significantly different from those at the time of 0 hour (all P > 0.05). Homocysteine 0-3 C-C motif chemokine ligand 2 Homo sapiens 183-188 16784723-5 2006 Antimycotics ketoconazole and terbinafine hydrochloride suppressed TNF-alpha-induced CCL27, CCL2, and CCL5 secretion and mRNA expression in keratinocytes in parallel to the inhibition of NF-kappaB activity while fluconazole was ineffective. Ketoconazole 13-25 C-C motif chemokine ligand 2 Homo sapiens 85-89 16784723-6 2006 Anti-prostaglandin E2 (PGE2) antiserum or antisense oligonucleotides against PGE2 receptor EP2 or EP3 abrogated inhibitory effects of ketoconazole and terbinafine hydrochloride on TNF-alpha-induced NF-kappaB activity and CCL27, CCL2, and CCL5 production, indicating the involvement of endogenous PGE2 in the inhibitory effects. Ketoconazole 134-146 C-C motif chemokine ligand 2 Homo sapiens 221-225 16784723-6 2006 Anti-prostaglandin E2 (PGE2) antiserum or antisense oligonucleotides against PGE2 receptor EP2 or EP3 abrogated inhibitory effects of ketoconazole and terbinafine hydrochloride on TNF-alpha-induced NF-kappaB activity and CCL27, CCL2, and CCL5 production, indicating the involvement of endogenous PGE2 in the inhibitory effects. Terbinafine 151-176 C-C motif chemokine ligand 2 Homo sapiens 221-225 16888027-7 2006 Importantly, Ets-1 antisense oligonucleotide markedly abrogated in vitro CCL2-induced angiogenesis, suggesting that Ets-1 is critically involved in this process. Oligonucleotides 29-44 C-C motif chemokine ligand 2 Homo sapiens 73-77 16888027-9 2006 CCL2 induced significant up-regulation of beta(3) mRNA and protein expression, and this effect of CCL2 was prevented by the Ets-1 antisense oligonucleotide. Oligonucleotides 140-155 C-C motif chemokine ligand 2 Homo sapiens 0-4 16888027-9 2006 CCL2 induced significant up-regulation of beta(3) mRNA and protein expression, and this effect of CCL2 was prevented by the Ets-1 antisense oligonucleotide. Oligonucleotides 140-155 C-C motif chemokine ligand 2 Homo sapiens 98-102 16888027-11 2006 Inhibition of ERK1/2 activity by PD98509 prevented CCL2-induced increases in Ets-1 DNA-binding activity and Ets-1 mRNA expression. pd98509 33-40 C-C motif chemokine ligand 2 Homo sapiens 51-55 16784723-6 2006 Anti-prostaglandin E2 (PGE2) antiserum or antisense oligonucleotides against PGE2 receptor EP2 or EP3 abrogated inhibitory effects of ketoconazole and terbinafine hydrochloride on TNF-alpha-induced NF-kappaB activity and CCL27, CCL2, and CCL5 production, indicating the involvement of endogenous PGE2 in the inhibitory effects. Dinoprostone 77-81 C-C motif chemokine ligand 2 Homo sapiens 221-225 16784723-5 2006 Antimycotics ketoconazole and terbinafine hydrochloride suppressed TNF-alpha-induced CCL27, CCL2, and CCL5 secretion and mRNA expression in keratinocytes in parallel to the inhibition of NF-kappaB activity while fluconazole was ineffective. Terbinafine 30-55 C-C motif chemokine ligand 2 Homo sapiens 85-89 16784723-9 2006 Carboxyheptyl imidazole also suppressed TNF-alpha-induced NF-kappaB activity and CCL27, CCL2, and CCL5 production. 1-carboxyheptylimidazole 0-23 C-C motif chemokine ligand 2 Homo sapiens 81-85 16784723-10 2006 These results suggest that ketoconazole and terbinafine hydrochloride may suppress TNF-alpha-induced NF-kappaB activity and CCL27, CCL2, and CCL5 production by increasing PGE2 release from keratinocytes. Ketoconazole 27-39 C-C motif chemokine ligand 2 Homo sapiens 124-128 16784723-6 2006 Anti-prostaglandin E2 (PGE2) antiserum or antisense oligonucleotides against PGE2 receptor EP2 or EP3 abrogated inhibitory effects of ketoconazole and terbinafine hydrochloride on TNF-alpha-induced NF-kappaB activity and CCL27, CCL2, and CCL5 production, indicating the involvement of endogenous PGE2 in the inhibitory effects. Dinoprostone 5-21 C-C motif chemokine ligand 2 Homo sapiens 221-225 16784723-10 2006 These results suggest that ketoconazole and terbinafine hydrochloride may suppress TNF-alpha-induced NF-kappaB activity and CCL27, CCL2, and CCL5 production by increasing PGE2 release from keratinocytes. Terbinafine 44-69 C-C motif chemokine ligand 2 Homo sapiens 124-128 16784723-6 2006 Anti-prostaglandin E2 (PGE2) antiserum or antisense oligonucleotides against PGE2 receptor EP2 or EP3 abrogated inhibitory effects of ketoconazole and terbinafine hydrochloride on TNF-alpha-induced NF-kappaB activity and CCL27, CCL2, and CCL5 production, indicating the involvement of endogenous PGE2 in the inhibitory effects. Dinoprostone 23-27 C-C motif chemokine ligand 2 Homo sapiens 221-225 16869002-8 2006 Treatment with EGCG at 10 microM or 20 microM significantly inhibited IL-1beta-induced ENA-78, RANTES, and GROalpha, but not MCP-1 production in a concentration-dependent manner. epigallocatechin gallate 15-19 C-C motif chemokine ligand 2 Homo sapiens 125-130 16867033-8 2006 After treatment with methylprednisolone, MS patients showed clinical improvement and the CSF concentrations of CCL2 and CXCL10 modified toward normal values. Methylprednisolone 21-39 C-C motif chemokine ligand 2 Homo sapiens 111-115 16867033-9 2006 CONCLUSIONS: The clinical improvement of active MS following the treatment with methylprednisolone was associated with the modification of CSF levels of CCL2 and CXCL10, suggesting that these chemokines may be useful markers of response to treatment and relapses in MS patients. Methylprednisolone 80-98 C-C motif chemokine ligand 2 Homo sapiens 153-157 16289073-6 2006 In addition, RANTES and MCP-1 upregulated cyclin D1 in the presence of pitavastatin. pitavastatin 71-83 C-C motif chemokine ligand 2 Homo sapiens 24-29 16855724-2 2006 The CCl(2) parent molecule was generated in a molecular beam by pyrolysis of CHCl(3), and both CCl(2) and the CCl photofragment were detected by laser fluorescence excitation. Cefaclor 4-7 C-C motif chemokine ligand 2 Homo sapiens 95-101 16855724-5 2006 The CCl(X (2)Pi, nu = 0) rotational state distribution was found to be bimodal, with maximum populations at N approximately 10 and 85, and was dependent upon the source backing pressure, and hence upon the internal state distribution of the CCl(2) precursor. Cefaclor 4-7 C-C motif chemokine ligand 2 Homo sapiens 241-247 16867033-0 2006 Effect of the treatment with methylprednisolone on the cerebrospinal fluid and serum levels of CCL2 and CXCL10 chemokines in patients with active multiple sclerosis. Methylprednisolone 29-47 C-C motif chemokine ligand 2 Homo sapiens 95-99 16867033-2 2006 Here, we evaluated the effect of intravenous methylprednisolone (IVMP) therapy on the levels of CCL2 and CXCL10 in the cerebrospinal fluid (CSF) and serum of patients with active MS. METHODS: Serum and CSF samples were obtained from 14 patients with active relapsing-remitting MS (age +/- SD years, 37.0 +/- 8.1; M/F, 6/8) and age- and gender-matched control subjects. Methylprednisolone 45-63 C-C motif chemokine ligand 2 Homo sapiens 96-100 16867033-2 2006 Here, we evaluated the effect of intravenous methylprednisolone (IVMP) therapy on the levels of CCL2 and CXCL10 in the cerebrospinal fluid (CSF) and serum of patients with active MS. METHODS: Serum and CSF samples were obtained from 14 patients with active relapsing-remitting MS (age +/- SD years, 37.0 +/- 8.1; M/F, 6/8) and age- and gender-matched control subjects. ivmp 65-69 C-C motif chemokine ligand 2 Homo sapiens 96-100 16246346-0 2006 3-Hydroxyanthranilic acid, one of L-tryptophan metabolites, inhibits monocyte chemoattractant protein-1 secretion and vascular cell adhesion molecule-1 expression via heme oxygenase-1 induction in human umbilical vein endothelial cells. 3-Hydroxyanthranilic Acid 0-25 C-C motif chemokine ligand 2 Homo sapiens 69-103 16246346-0 2006 3-Hydroxyanthranilic acid, one of L-tryptophan metabolites, inhibits monocyte chemoattractant protein-1 secretion and vascular cell adhesion molecule-1 expression via heme oxygenase-1 induction in human umbilical vein endothelial cells. Tryptophan 34-46 C-C motif chemokine ligand 2 Homo sapiens 69-103 16869002-9 2006 EGCG at 50 microM caused a complete block of IL-1beta-induced production of RANTES, ENA-78, and GROalpha, and reduced production of MCP-1 by 48% (P < 0.05). epigallocatechin gallate 0-4 C-C motif chemokine ligand 2 Homo sapiens 132-137 16890787-0 2006 Changes in specific IgE and IgG and monocyte chemoattractant protein-1 in workers with occupational asthma caused by diisocyanates and removed from exposure. 4,4'-diphenylmethane diisocyanate 117-130 C-C motif chemokine ligand 2 Homo sapiens 36-70 16735126-0 2006 Effects of sulfate position on heparin octasaccharide binding to CCL2 examined by tandem mass spectrometry. Sulfates 11-18 C-C motif chemokine ligand 2 Homo sapiens 65-69 16735126-0 2006 Effects of sulfate position on heparin octasaccharide binding to CCL2 examined by tandem mass spectrometry. heparin octasaccharide 31-53 C-C motif chemokine ligand 2 Homo sapiens 65-69 16735126-3 2006 In a recent study, FT-ICR mass spectrometry was used to show that the chemokine CCL2 (monocyte chemoattractant protein 1) binds only to the 11- and 12-sulfated components of a heparin octasaccharide library. heparin octasaccharide 176-198 C-C motif chemokine ligand 2 Homo sapiens 80-84 16735126-3 2006 In a recent study, FT-ICR mass spectrometry was used to show that the chemokine CCL2 (monocyte chemoattractant protein 1) binds only to the 11- and 12-sulfated components of a heparin octasaccharide library. heparin octasaccharide 176-198 C-C motif chemokine ligand 2 Homo sapiens 86-120 16735126-5 2006 In the current study, the composition of the 11-sulfated heparin octasaccharides, as well as the composition of CCL2 affinity purified 11-sulfated heparin octasaccharides, were examined by tandem MS. Of the three possible singly desulfated disaccharides, one species, III-S, is enriched by CCL2 affinity purification, indicating that the 11-sulfated heparin octasaccharides containing this disaccharide are preferentially bound to CCL2. 11-sulfated heparin octasaccharides 135-170 C-C motif chemokine ligand 2 Homo sapiens 112-116 16735126-5 2006 In the current study, the composition of the 11-sulfated heparin octasaccharides, as well as the composition of CCL2 affinity purified 11-sulfated heparin octasaccharides, were examined by tandem MS. Of the three possible singly desulfated disaccharides, one species, III-S, is enriched by CCL2 affinity purification, indicating that the 11-sulfated heparin octasaccharides containing this disaccharide are preferentially bound to CCL2. 11-sulfated heparin octasaccharides 135-170 C-C motif chemokine ligand 2 Homo sapiens 112-116 16735126-6 2006 These data suggest that 2-O and N sulfation of heparin may be of greater importance to CCL2-heparin binding than 6-O sulfation. hippuric acid 24-27 C-C motif chemokine ligand 2 Homo sapiens 87-91 16804844-3 2006 The monocyte chemoattractant protein-1 (CCL2/MCP-1) has been shown to enhance the uptake of T. cruzi in murine macrophages and to up-regulate the inducible nitric oxide synthase/nitric oxide system, with a consequent increased production of nitric oxide that controls the replication of the parasite. Nitric Oxide 156-168 C-C motif chemokine ligand 2 Homo sapiens 4-38 16804844-3 2006 The monocyte chemoattractant protein-1 (CCL2/MCP-1) has been shown to enhance the uptake of T. cruzi in murine macrophages and to up-regulate the inducible nitric oxide synthase/nitric oxide system, with a consequent increased production of nitric oxide that controls the replication of the parasite. Nitric Oxide 178-190 C-C motif chemokine ligand 2 Homo sapiens 4-38 16491109-8 2006 RESULTS: Subjects receiving folic acid supplementation showed a decrement of homocysteine and an amelioration of insulin sensitivity; this treatment was also associated with a significant drop in the circulating concentration of monocyte chemoattractant protein-1, interleukin-8 and C-reactive protein, in the absence of any significant variation of BMI or fat mass. Folic Acid 28-38 C-C motif chemokine ligand 2 Homo sapiens 229-263 16735126-6 2006 These data suggest that 2-O and N sulfation of heparin may be of greater importance to CCL2-heparin binding than 6-O sulfation. Nitrogen 32-33 C-C motif chemokine ligand 2 Homo sapiens 87-91 16537813-5 2006 LPS-induced CCL-2/MCP-1 and CCL5/RANTES secretions by DCs were prevented by DC treatment with bortezomib. Bortezomib 94-104 C-C motif chemokine ligand 2 Homo sapiens 12-17 16735126-6 2006 These data suggest that 2-O and N sulfation of heparin may be of greater importance to CCL2-heparin binding than 6-O sulfation. Heparin 47-54 C-C motif chemokine ligand 2 Homo sapiens 87-91 16797033-0 2006 Effect of berberrubine on interleukin-8 and monocyte chemotactic protein-1 expression in human retinal pigment epithelial cell line. berberrubine 10-22 C-C motif chemokine ligand 2 Homo sapiens 44-74 16797033-1 2006 We examined the effects of berberrubine, a protoberberine alkaloid, on interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) expression in a human retinal pigment epithelial cell line (ARPE-19) stimulated with interleukin-1beta (IL-1beta) or tumor necrosis factor alpha (TNF-alpha). berberrubine 27-39 C-C motif chemokine ligand 2 Homo sapiens 96-126 16797033-7 2006 Berberrubine dose-dependently inhibited IL-8 and MCP-1 protein levels in the media and mRNA expression of the cells stimulated with IL-1beta or TNF-alpha. berberrubine 0-12 C-C motif chemokine ligand 2 Homo sapiens 49-54 16797033-10 2006 Berberrubine dose-dependently inhibited IL-8 and MCP-1 expression and protein secretion induced by IL-1beta or TNF-alpha. berberrubine 0-12 C-C motif chemokine ligand 2 Homo sapiens 49-54 16537813-5 2006 LPS-induced CCL-2/MCP-1 and CCL5/RANTES secretions by DCs were prevented by DC treatment with bortezomib. Bortezomib 94-104 C-C motif chemokine ligand 2 Homo sapiens 18-23 16644035-0 2006 Isoproterenol stimulates monocyte chemoattractant protein-1 expression and secretion in 3T3-L1 adipocytes. Isoproterenol 0-13 C-C motif chemokine ligand 2 Homo sapiens 25-59 16698264-3 2006 Functionally, it blocked MCP-1 (CCL2)-induced calcium mobilization (IC50=50 nM) and chemotaxis mediated through the CCR2 receptor (9.6 nM). Calcium 46-53 C-C motif chemokine ligand 2 Homo sapiens 25-30 16698264-3 2006 Functionally, it blocked MCP-1 (CCL2)-induced calcium mobilization (IC50=50 nM) and chemotaxis mediated through the CCR2 receptor (9.6 nM). Calcium 46-53 C-C motif chemokine ligand 2 Homo sapiens 32-36 16644035-3 2006 In the current study, the impact of the beta-adrenergic agonist isoproterenol on MCP-1 mRNA synthesis and secretion was determined in 3T3-L1 adipocytes. Isoproterenol 64-77 C-C motif chemokine ligand 2 Homo sapiens 81-86 16644035-4 2006 Interestingly, isoproterenol increased MCP-1 secretion 3-fold. Isoproterenol 15-28 C-C motif chemokine ligand 2 Homo sapiens 39-44 16644035-5 2006 Furthermore, 10 microM isoproterenol acutely induced MCP-1 mRNA by up to 5.3-fold in a time-dependent fashion with significant stimulation seen at concentrations as low as 0.3 microM effector. Isoproterenol 23-36 C-C motif chemokine ligand 2 Homo sapiens 53-58 16644035-6 2006 Studies using pharmacological inhibitors suggested that basal and isoproterenol-induced MCP-1 expressions are mediated via beta-adrenergic receptors and protein kinase A. Isoproterenol 66-79 C-C motif chemokine ligand 2 Homo sapiens 88-93 16644035-8 2006 Taken together, our results demonstrate that isoproterenol induces MCP-1 expression and secretion via a classical GS-protein-coupled pathway and support the notion that MCP-1 might be an interesting novel candidate linking obesity and insulin resistance. Isoproterenol 45-58 C-C motif chemokine ligand 2 Homo sapiens 67-72 16644035-8 2006 Taken together, our results demonstrate that isoproterenol induces MCP-1 expression and secretion via a classical GS-protein-coupled pathway and support the notion that MCP-1 might be an interesting novel candidate linking obesity and insulin resistance. Isoproterenol 45-58 C-C motif chemokine ligand 2 Homo sapiens 169-174 16712788-4 2006 While AAPH treatment reduced cell viability, increased F(2)-isoprostanes and MCP-1 production, the presence of intracellular ascorbic acid maintained high cell viability and attenuated both F(2)-isoprostanes and MCP-1 production. Ascorbic Acid 125-138 C-C motif chemokine ligand 2 Homo sapiens 212-217 16834783-14 2006 Like dexamethasone and mometasone, RU24858 did suppress IL-8 and MCP-1 production in eosinophils. RU24858 35-42 C-C motif chemokine ligand 2 Homo sapiens 65-70 16569732-2 2006 OBJECTIVE: This study was designed to investigate the effect of spironolactone, an aldosterone blocker, on oxidative stress and the level of urinary monocyte chemoattractant protein (MCP)-1, a cysteine-cysteine chemokine that may contribute to progression of various nephropathies in type 2 diabetic patients with diabetic nephropathy. Spironolactone 64-78 C-C motif chemokine ligand 2 Homo sapiens 149-189 16522819-4 2006 Adenosine compounds also desensitized IL-8- and MCP-1-induced chemotaxis, but not that induced by fMLP. Adenosine 0-9 C-C motif chemokine ligand 2 Homo sapiens 48-53 16799229-3 2006 METHODS AND RESULTS: Multiple regression analysis indicated that the MCP-1 levels were significantly influenced by various factors including age, body mass index, smoking, alcohol intake, high density lipoprotein-cholesterol, and systolic blood pressure. Alcohols 172-179 C-C motif chemokine ligand 2 Homo sapiens 69-74 16750572-5 2006 Therefore, we attempted to investigate the effect of MH2 on expression of MCP-1 and other immunolmodulators in CNS cells. MH2 53-56 C-C motif chemokine ligand 2 Homo sapiens 74-79 16750572-6 2006 By employing an adenovirus expression vector, we demonstrated that MH2 can decrease the levels of Tat-induced activation of MCP-1 and several other cytokines and chemokines in astrocytic cells. MH2 67-70 C-C motif chemokine ligand 2 Homo sapiens 124-129 16631114-7 2006 In diabetic patients, serum MCP-1 levels correlated significantly with FPG, HbA1c, triglyceride, BMI, and hs-CRP. Triglycerides 83-95 C-C motif chemokine ligand 2 Homo sapiens 28-33 16631114-9 2006 Our data suggest that elevated serum MCP-1 levels and increased monocyte CCR2, CD36, CD68 expression correlate with poor blood glucose control and potentially contribute to increased recruitment of monocytes to the vessel wall in diabetes mellitus. Glucose 127-134 C-C motif chemokine ligand 2 Homo sapiens 37-42 16445900-4 2006 RESULTS: In healthy participants there were significant associations between plasma MCP-1 concentration and age, smoking status, and serum triglyceride concentrations that were not observed in the HIV-infected patients. Triglycerides 139-151 C-C motif chemokine ligand 2 Homo sapiens 84-89 16636195-6 2006 Furthermore, metformin attenuated the TNF-alpha-induced gene expression of various proinflammatory and cell adhesion molecules, such as vascular cell adhesion molecule-1, E-selectin, intercellular adhesion molecule-1, and monocyte chemoattractant protein-1, in HUVECs. Metformin 13-22 C-C motif chemokine ligand 2 Homo sapiens 222-256 16729291-5 2006 We further demonstrate that lovastatin and simvastatin treatment of BBB-ECs significantly restricts the migration of clinically isolated syndrome-derived and MS-derived monocytes and lymphocytes across the human BBB in vitro, through a specific reduction in the secretion of the chemokines monocyte chemotactic protein-1/CCL2 and interferon-gamma-inducible protein-10/CXCL10 by BBB-ECs. Lovastatin 28-38 C-C motif chemokine ligand 2 Homo sapiens 290-320 16729291-5 2006 We further demonstrate that lovastatin and simvastatin treatment of BBB-ECs significantly restricts the migration of clinically isolated syndrome-derived and MS-derived monocytes and lymphocytes across the human BBB in vitro, through a specific reduction in the secretion of the chemokines monocyte chemotactic protein-1/CCL2 and interferon-gamma-inducible protein-10/CXCL10 by BBB-ECs. Lovastatin 28-38 C-C motif chemokine ligand 2 Homo sapiens 321-325 16729291-5 2006 We further demonstrate that lovastatin and simvastatin treatment of BBB-ECs significantly restricts the migration of clinically isolated syndrome-derived and MS-derived monocytes and lymphocytes across the human BBB in vitro, through a specific reduction in the secretion of the chemokines monocyte chemotactic protein-1/CCL2 and interferon-gamma-inducible protein-10/CXCL10 by BBB-ECs. Simvastatin 43-54 C-C motif chemokine ligand 2 Homo sapiens 290-320 16729291-5 2006 We further demonstrate that lovastatin and simvastatin treatment of BBB-ECs significantly restricts the migration of clinically isolated syndrome-derived and MS-derived monocytes and lymphocytes across the human BBB in vitro, through a specific reduction in the secretion of the chemokines monocyte chemotactic protein-1/CCL2 and interferon-gamma-inducible protein-10/CXCL10 by BBB-ECs. Simvastatin 43-54 C-C motif chemokine ligand 2 Homo sapiens 321-325 16837769-1 2006 We evaluated the effect of alacepril, CV-11974, and spironolactone on the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) in cultured human peripheral blood mononuclear cells stimulated with angiotensin (Ang) II. alacepril 27-36 C-C motif chemokine ligand 2 Homo sapiens 88-122 16837769-1 2006 We evaluated the effect of alacepril, CV-11974, and spironolactone on the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) in cultured human peripheral blood mononuclear cells stimulated with angiotensin (Ang) II. alacepril 27-36 C-C motif chemokine ligand 2 Homo sapiens 124-129 16837769-1 2006 We evaluated the effect of alacepril, CV-11974, and spironolactone on the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) in cultured human peripheral blood mononuclear cells stimulated with angiotensin (Ang) II. Spironolactone 52-66 C-C motif chemokine ligand 2 Homo sapiens 88-122 16837769-1 2006 We evaluated the effect of alacepril, CV-11974, and spironolactone on the production of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha (TNF-alpha) in cultured human peripheral blood mononuclear cells stimulated with angiotensin (Ang) II. Spironolactone 52-66 C-C motif chemokine ligand 2 Homo sapiens 124-129 16837769-2 2006 Alacepril, CV-11974, and spironolactone significantly reduced the enhanced production of MCP-1 and TNF-alpha induced by exogenous Ang II. alacepril 0-9 C-C motif chemokine ligand 2 Homo sapiens 89-94 16837769-2 2006 Alacepril, CV-11974, and spironolactone significantly reduced the enhanced production of MCP-1 and TNF-alpha induced by exogenous Ang II. Spironolactone 25-39 C-C motif chemokine ligand 2 Homo sapiens 89-94 16192992-5 2006 Applying antisense oligonucleotide or neutralizing antibody to block CCL2 significantly decreased I/R-induced enhancement of BBB permeability (approximately twofold) and redistribution of tight-junction (TJ) proteins (occludin, zonula occluden-1, 2, claudin-5). Oligonucleotides 19-34 C-C motif chemokine ligand 2 Homo sapiens 69-73 16569732-6 2006 RESULTS: There were significant positive correlations between log(10)-transformed (log) 8-iso-PGF2alpha and log MCP-1 levels in control and diabetic subjects and all subjects combined, but no correlations between log UAE and log 8-iso-PGF2alpha or log MCP-1 were found in any group. 8-epi-prostaglandin F2alpha 88-103 C-C motif chemokine ligand 2 Homo sapiens 112-117 16569732-7 2006 Significant decreases in 8-iso-PGF2alpha, MCP-1, and UAE were observed with spironolactone (P = 0.0001, P = 0.0041, and P = 0.0037, respectively), and systolic blood pressure significantly decreased after both spironolactone and amlodipine therapy (P = 0.00011 and P = 0.0051, respectively). Spironolactone 76-90 C-C motif chemokine ligand 2 Homo sapiens 42-47 16569732-8 2006 CONCLUSIONS: Our data suggest that urinary MCP-1 is correlated with oxidative stress as measured by urinary 8-iso-PGF2alpha and that spironolactone can decrease urinary MCP-1 and oxidative stress. 8-epi-prostaglandin F2alpha 108-123 C-C motif chemokine ligand 2 Homo sapiens 43-48 16569732-8 2006 CONCLUSIONS: Our data suggest that urinary MCP-1 is correlated with oxidative stress as measured by urinary 8-iso-PGF2alpha and that spironolactone can decrease urinary MCP-1 and oxidative stress. Spironolactone 133-147 C-C motif chemokine ligand 2 Homo sapiens 169-174 16815071-6 2006 TsAg induced maximal nuclear binding of p65, p50 and c-rel subunits of the transcriptional regulator NF-kappaB by 2 h. IkappaBalpha but not IkappaBbeta was degraded within 10 min before resynthesis by 2 h. Pre-treatment with the broad-spectrum NF-kappaB inhibitor pyrrolidine dithiocarbamate caused complete abrogation of TsAg-induced CCL2 secretion (p=0.005) and 91% reduction of CXCL8 secretion (p=0.0003). tsag 0-4 C-C motif chemokine ligand 2 Homo sapiens 335-339 16600694-0 2006 Aspirin and PPAR-alpha activators inhibit monocyte chemoattractant protein-1 expression induced by high glucose concentration in human endothelial cells. Glucose 104-111 C-C motif chemokine ligand 2 Homo sapiens 42-76 16600694-0 2006 Aspirin and PPAR-alpha activators inhibit monocyte chemoattractant protein-1 expression induced by high glucose concentration in human endothelial cells. Aspirin 0-7 C-C motif chemokine ligand 2 Homo sapiens 42-76 16771778-8 2006 Montelukast also abolished MCP-1-induced [Ca2+]i and pp38 MAPK expression in THP-1 cells in a dose-dependent manner. montelukast 0-11 C-C motif chemokine ligand 2 Homo sapiens 27-32 16771778-9 2006 These data demonstrate that montelukast is effective in down-regulating human monocyte chemotaxis induced by MCP-1. montelukast 28-39 C-C motif chemokine ligand 2 Homo sapiens 109-114 16600694-5 2006 The results showed that (i) aspirin, fenofibrate and clofibrate decrease significantly the MCP-1 expression and secretion in human endothelial cells; (ii) the high glucose up-regulated expression of MCP-1 in endothelial cells was significantly reduced by inhibitors of NF-kB and reactive oxygen species; (iii) all drugs notably decrease the level of the reactive oxygen species and activation of NF-kB and AP-1. Aspirin 28-35 C-C motif chemokine ligand 2 Homo sapiens 91-96 16600694-5 2006 The results showed that (i) aspirin, fenofibrate and clofibrate decrease significantly the MCP-1 expression and secretion in human endothelial cells; (ii) the high glucose up-regulated expression of MCP-1 in endothelial cells was significantly reduced by inhibitors of NF-kB and reactive oxygen species; (iii) all drugs notably decrease the level of the reactive oxygen species and activation of NF-kB and AP-1. Fenofibrate 37-48 C-C motif chemokine ligand 2 Homo sapiens 91-96 16600694-5 2006 The results showed that (i) aspirin, fenofibrate and clofibrate decrease significantly the MCP-1 expression and secretion in human endothelial cells; (ii) the high glucose up-regulated expression of MCP-1 in endothelial cells was significantly reduced by inhibitors of NF-kB and reactive oxygen species; (iii) all drugs notably decrease the level of the reactive oxygen species and activation of NF-kB and AP-1. Clofibrate 53-63 C-C motif chemokine ligand 2 Homo sapiens 91-96 16600694-5 2006 The results showed that (i) aspirin, fenofibrate and clofibrate decrease significantly the MCP-1 expression and secretion in human endothelial cells; (ii) the high glucose up-regulated expression of MCP-1 in endothelial cells was significantly reduced by inhibitors of NF-kB and reactive oxygen species; (iii) all drugs notably decrease the level of the reactive oxygen species and activation of NF-kB and AP-1. Glucose 164-171 C-C motif chemokine ligand 2 Homo sapiens 91-96 16600694-6 2006 Together, the findings indicate that in endothelial cells aspirin and PPAR-alpha activators reduce the high glucose-increased expression of MCP-1 by a mechanism that includes the inhibition of reactive oxygen species, and decrease of AP-1 and NF-kB activation. Aspirin 58-65 C-C motif chemokine ligand 2 Homo sapiens 140-145 16600694-6 2006 Together, the findings indicate that in endothelial cells aspirin and PPAR-alpha activators reduce the high glucose-increased expression of MCP-1 by a mechanism that includes the inhibition of reactive oxygen species, and decrease of AP-1 and NF-kB activation. Glucose 108-115 C-C motif chemokine ligand 2 Homo sapiens 140-145 16600694-6 2006 Together, the findings indicate that in endothelial cells aspirin and PPAR-alpha activators reduce the high glucose-increased expression of MCP-1 by a mechanism that includes the inhibition of reactive oxygen species, and decrease of AP-1 and NF-kB activation. Reactive Oxygen Species 193-216 C-C motif chemokine ligand 2 Homo sapiens 140-145 16376386-4 2006 Scoparone concentration-dependently reduced the release of IL-8 and MCP-1 protein and expression of IL-8 and MCP-1 mRNA levels induced by PMA. scoparone 0-9 C-C motif chemokine ligand 2 Homo sapiens 109-114 16376386-0 2006 Scoparone inhibits PMA-induced IL-8 and MCP-1 production through suppression of NF-kappaB activation in U937 cells. scoparone 0-9 C-C motif chemokine ligand 2 Homo sapiens 40-45 16376386-0 2006 Scoparone inhibits PMA-induced IL-8 and MCP-1 production through suppression of NF-kappaB activation in U937 cells. Tetradecanoylphorbol Acetate 19-22 C-C motif chemokine ligand 2 Homo sapiens 40-45 16604541-8 2006 RESULTS: All oxysterols investigated are potent in vitro inducers of MCP-1, MIP-1beta, TNF-alpha, and/or IL-8 secretion, the latter involving the MEK/ERK1/2 cell signaling pathway. Oxysterols 13-23 C-C motif chemokine ligand 2 Homo sapiens 69-74 16376386-2 2006 In this study, the effects of scoparone on the expression of interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) and activation of nuclear factor-kappaB (NF-kappaB) were examined in U937 human monocytes activated with phorbol 12-myristate 13-acetate (PMA). scoparone 30-39 C-C motif chemokine ligand 2 Homo sapiens 86-116 16376386-2 2006 In this study, the effects of scoparone on the expression of interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) and activation of nuclear factor-kappaB (NF-kappaB) were examined in U937 human monocytes activated with phorbol 12-myristate 13-acetate (PMA). scoparone 30-39 C-C motif chemokine ligand 2 Homo sapiens 118-123 16376386-4 2006 Scoparone concentration-dependently reduced the release of IL-8 and MCP-1 protein and expression of IL-8 and MCP-1 mRNA levels induced by PMA. scoparone 0-9 C-C motif chemokine ligand 2 Homo sapiens 68-73 16866022-5 2006 Tamoxifen inhibited MCP-1 mRNA and protein expression in endometrial cancer cells and inhibited MCP-1 secretion in a time- and dose-dependent manner at concentrations of 10(-7) to 10(-5) M. Buserelin had no significant effect on MCP-1 mRNA and protein expression. Tamoxifen 0-9 C-C motif chemokine ligand 2 Homo sapiens 20-25 16439461-6 2006 In addition, MCP-1 significantly reduced insulin-stimulated glucose uptake in the myocytes. Glucose 60-67 C-C motif chemokine ligand 2 Homo sapiens 13-18 16439461-10 2006 Human skeletal muscle cells are highly sensitive toward MCP-1, which impairs insulin signaling and glucose uptake at concentrations even below that found in the circulation. Glucose 99-106 C-C motif chemokine ligand 2 Homo sapiens 56-61 16410784-4 2006 Addition of the hydrolysis-resistant ATP analogue, adenosine 5"-O-(3-thiotriphosphate) (ATPgammaS), to subconfluent cultures of the human microvascular endothelial cell-1 (HMEC-1) cell line led to a dose- and time-dependent increase in release of IL-6, IL-8, monocyte chemoattractant protein-1, and growth-regulated oncogene alpha. adenosine 5'-O-(3-thiotriphosphate) 51-86 C-C motif chemokine ligand 2 Homo sapiens 259-293 16866022-5 2006 Tamoxifen inhibited MCP-1 mRNA and protein expression in endometrial cancer cells and inhibited MCP-1 secretion in a time- and dose-dependent manner at concentrations of 10(-7) to 10(-5) M. Buserelin had no significant effect on MCP-1 mRNA and protein expression. Tamoxifen 0-9 C-C motif chemokine ligand 2 Homo sapiens 96-101 16866022-5 2006 Tamoxifen inhibited MCP-1 mRNA and protein expression in endometrial cancer cells and inhibited MCP-1 secretion in a time- and dose-dependent manner at concentrations of 10(-7) to 10(-5) M. Buserelin had no significant effect on MCP-1 mRNA and protein expression. Tamoxifen 0-9 C-C motif chemokine ligand 2 Homo sapiens 96-101 16084091-5 2006 We also investigated the serine phosphorylation of STAT1, -3, and -5 under hypoxic conditions or DFO treatment in HC11 and MCF-7 cells. Serine 25-31 C-C motif chemokine ligand 2 Homo sapiens 114-118 16282363-6 2006 MCP-1 induces proliferation, increase and redistribution of alpha-smooth muscle (alpha-SMA) expression, loss of the ectonucleotidase NTPDase2, and upregulation of alpha(1)-procollagen production in PF. alpha(1)-procollagen 163-183 C-C motif chemokine ligand 2 Homo sapiens 0-5 16282363-7 2006 BDE secretions induce alpha-SMA levels in PF, and this is inhibited by MCP-1 blocking antibody. 3,4-epoxy-1,2,3,4-tetrahydrobenzene-1,2-diol 0-3 C-C motif chemokine ligand 2 Homo sapiens 71-76 16002160-6 2006 RESULTS: Serum levels of MCP-1 and sVCAM-1 were significantly increased in the control group (p < 0.05) while remained unaffected in the atorvastatin-treated group six weeks after admission. Atorvastatin 140-152 C-C motif chemokine ligand 2 Homo sapiens 25-30 16505207-5 2006 Treatment with ARB (candesartan 8 mg/day, n=11 or valsartan 80 mg/day, n=22) for 8 weeks reduced the levels of plasma monocyte chemoattractant protein 1, interleukin 6, urinary 8-epi-prostaglandin F2alpha, 8-hydroxydeoxyguanosine, albumin, and type IV collagen, whereas the levels of these markers were not altered with trichlormethiazide (2 mg/day). candesartan 20-31 C-C motif chemokine ligand 2 Homo sapiens 118-152 16505207-5 2006 Treatment with ARB (candesartan 8 mg/day, n=11 or valsartan 80 mg/day, n=22) for 8 weeks reduced the levels of plasma monocyte chemoattractant protein 1, interleukin 6, urinary 8-epi-prostaglandin F2alpha, 8-hydroxydeoxyguanosine, albumin, and type IV collagen, whereas the levels of these markers were not altered with trichlormethiazide (2 mg/day). Valsartan 50-59 C-C motif chemokine ligand 2 Homo sapiens 118-152 16541021-0 2006 Pentoxifylline ameliorates proteinuria through suppression of renal monocyte chemoattractant protein-1 in patients with proteinuric primary glomerular diseases. Pentoxifylline 0-14 C-C motif chemokine ligand 2 Homo sapiens 68-102 16352705-5 2006 In primary human peripheral blood mononuclear cells, dose-dependent inhibition of LPS-induced tumor necrosis factor (TNF)-alpha, IL-6, MCP-1, and IL-1beta by tipifarnib was observed with no evidence of cytotoxicity. tipifarnib 158-168 C-C motif chemokine ligand 2 Homo sapiens 135-140 16482103-0 2006 Nitric oxide suppresses EPO-induced monocyte chemoattractant protein-1 in endothelial cells: implications for atherogenesis in chronic renal disease. Nitric Oxide 0-12 C-C motif chemokine ligand 2 Homo sapiens 36-70 16392133-2 2006 We have previously reported that titanium particles stimulate the selective induction of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) chemokines in human osteoblast-like osteosarcoma cells. Titanium 33-41 C-C motif chemokine ligand 2 Homo sapiens 114-148 16392133-2 2006 We have previously reported that titanium particles stimulate the selective induction of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) chemokines in human osteoblast-like osteosarcoma cells. Titanium 33-41 C-C motif chemokine ligand 2 Homo sapiens 150-155 16392133-4 2006 We demonstrate that titanium particles result in enhanced IL-8 and MCP-1 protein secretion as well as differential chemokine gene activation. Titanium 20-28 C-C motif chemokine ligand 2 Homo sapiens 67-72 16541021-7 2006 A significant correlation existed between the basal urinary protein/Cr and the basal urinary MCP-1/Cr ratios. Creatinine 68-70 C-C motif chemokine ligand 2 Homo sapiens 93-98 16609688-6 2006 Iron sucrose markedly increased plasma concentration and urinary excretion rate of MCP-1 at baseline and at 1 week visits (P < 0.0001 for time effect). Ferric Oxide, Saccharated 0-12 C-C motif chemokine ligand 2 Homo sapiens 83-88 16541021-8 2006 PTX lowered the urinary MCP-1/Cr ratio, and the percent reduction of urinary protein/Cr ratio correlated directly with the precent decrease of urinary MCP-1/Cr ratio after PTX treatment. Pentoxifylline 0-3 C-C motif chemokine ligand 2 Homo sapiens 24-29 16609688-8 2006 Plasma MCP-1 concentration fell from 164 +/- 17.7 to 135 +/- 17.7 pg/ml with NAC, whereas it remained unchanged from 133 +/- 12.5 to 132 +/- 17.7 pg/ml with placebo (P=0.001 for visit x antioxidant drug interaction). Acetylcysteine 77-80 C-C motif chemokine ligand 2 Homo sapiens 7-12 16541021-8 2006 PTX lowered the urinary MCP-1/Cr ratio, and the percent reduction of urinary protein/Cr ratio correlated directly with the precent decrease of urinary MCP-1/Cr ratio after PTX treatment. Pentoxifylline 0-3 C-C motif chemokine ligand 2 Homo sapiens 151-156 16541021-8 2006 PTX lowered the urinary MCP-1/Cr ratio, and the percent reduction of urinary protein/Cr ratio correlated directly with the precent decrease of urinary MCP-1/Cr ratio after PTX treatment. Creatinine 85-87 C-C motif chemokine ligand 2 Homo sapiens 151-156 16609688-12 2006 In conclusion, iron sucrose causes rapid and transient generation and/or release of MCP-1 plasma concentration and increases urinary excretion rate, and systemic MCP-1 level but the urinary excretion rate is not abrogated with the antioxidant NAC. Ferric Oxide, Saccharated 15-27 C-C motif chemokine ligand 2 Homo sapiens 84-89 16541021-8 2006 PTX lowered the urinary MCP-1/Cr ratio, and the percent reduction of urinary protein/Cr ratio correlated directly with the precent decrease of urinary MCP-1/Cr ratio after PTX treatment. Creatinine 85-87 C-C motif chemokine ligand 2 Homo sapiens 151-156 16609688-12 2006 In conclusion, iron sucrose causes rapid and transient generation and/or release of MCP-1 plasma concentration and increases urinary excretion rate, and systemic MCP-1 level but the urinary excretion rate is not abrogated with the antioxidant NAC. Ferric Oxide, Saccharated 15-27 C-C motif chemokine ligand 2 Homo sapiens 162-167 16541021-8 2006 PTX lowered the urinary MCP-1/Cr ratio, and the percent reduction of urinary protein/Cr ratio correlated directly with the precent decrease of urinary MCP-1/Cr ratio after PTX treatment. Pentoxifylline 172-175 C-C motif chemokine ligand 2 Homo sapiens 151-156 16609688-12 2006 In conclusion, iron sucrose causes rapid and transient generation and/or release of MCP-1 plasma concentration and increases urinary excretion rate, and systemic MCP-1 level but the urinary excretion rate is not abrogated with the antioxidant NAC. Acetylcysteine 243-246 C-C motif chemokine ligand 2 Homo sapiens 84-89 16465414-1 2006 We previously demonstrated the doxorubicin-induced expression of urokinase-type plasminogen activator (uPA), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-alpha in human RC-K8 lymphoma cells and NCI-H69 small cell lung carcinoma cells in which reactive oxygen species might be involved. Doxorubicin 31-42 C-C motif chemokine ligand 2 Homo sapiens 131-165 16631375-9 2006 These results indicate that GL inhibits PMN-II-stimulated M2Mphi generation through the inhibition of CCL2/interleukin-10 production by PMN-II. Glycyrrhizic Acid 28-30 C-C motif chemokine ligand 2 Homo sapiens 102-106 16169205-12 2006 Drinking gazpacho (500 ml/day) significantly increases plasma concentrations of vitamin C and significantly decreases 8-epi-PGF2alpha, PGE2 and MCP-1 concentrations in healthy humans. gazpacho 9-17 C-C motif chemokine ligand 2 Homo sapiens 144-149 16339163-11 2006 The secretions of CCL2/MCP-1 and CXCL2/MIP-2 stimulated by LMPS were significantly reduced by incubating PTECs with SB203580, an inhibitor of p38 MAPK. SB 203580 116-124 C-C motif chemokine ligand 2 Homo sapiens 18-22 16339163-11 2006 The secretions of CCL2/MCP-1 and CXCL2/MIP-2 stimulated by LMPS were significantly reduced by incubating PTECs with SB203580, an inhibitor of p38 MAPK. SB 203580 116-124 C-C motif chemokine ligand 2 Homo sapiens 23-28 16445950-7 2006 Expression and production of MCP-1 and IL-4 were significantly increased in AD subjects under therapy with the AChEI Donepezil, compared to the same AD patients at time of enrollment (P < 0.001). Donepezil 117-126 C-C motif chemokine ligand 2 Homo sapiens 29-34 16445950-8 2006 Our data suggest another possible explanation for the ability of Donepezil [diethyl(3,5-di-ter-butyl-4-hydroxybenzyl)phosphonate] to delay the progression of AD; in fact, Donepezil may modulate MCP-1 and IL-4 production, which may reflect a general shift towards type Th0/Th2 cytokines which could be protective in AD disease. Donepezil 65-74 C-C motif chemokine ligand 2 Homo sapiens 194-199 16445950-8 2006 Our data suggest another possible explanation for the ability of Donepezil [diethyl(3,5-di-ter-butyl-4-hydroxybenzyl)phosphonate] to delay the progression of AD; in fact, Donepezil may modulate MCP-1 and IL-4 production, which may reflect a general shift towards type Th0/Th2 cytokines which could be protective in AD disease. diethyl(3,5-di-ter-butyl-4-hydroxybenzyl)phosphonate 76-128 C-C motif chemokine ligand 2 Homo sapiens 194-199 16445950-8 2006 Our data suggest another possible explanation for the ability of Donepezil [diethyl(3,5-di-ter-butyl-4-hydroxybenzyl)phosphonate] to delay the progression of AD; in fact, Donepezil may modulate MCP-1 and IL-4 production, which may reflect a general shift towards type Th0/Th2 cytokines which could be protective in AD disease. Donepezil 171-180 C-C motif chemokine ligand 2 Homo sapiens 194-199 16439355-3 2006 The CCL2-induced alterations in the brain endothelial barrier were associated with de novo Ser/Thr phosphorylation of occludin, ZO-1, ZO-2, and claudin-5. Serine 91-94 C-C motif chemokine ligand 2 Homo sapiens 4-8 16439355-3 2006 The CCL2-induced alterations in the brain endothelial barrier were associated with de novo Ser/Thr phosphorylation of occludin, ZO-1, ZO-2, and claudin-5. Threonine 95-98 C-C motif chemokine ligand 2 Homo sapiens 4-8 16539510-0 2006 Evolution of the electronic properties of metallic single-walled carbon nanotubes with the degree of CCl2 covalent functionalization. Carbon 65-71 C-C motif chemokine ligand 2 Homo sapiens 101-105 16539510-1 2006 The changes in energetic, structural, and electronic properties of the metallic (5,5) single-walled carbon nanotube (SWNT) with the degree of sidewall covalent functionalization of CCl(2) are investigated extensively by using density functional theory calculations. Carbon 100-106 C-C motif chemokine ligand 2 Homo sapiens 181-186 16463434-9 2006 MCP-1 concentrations were correlated with SLEDAI (p = 0.01), ESR (p = 0.04), and triglycerides (p = 0.03). Triglycerides 81-94 C-C motif chemokine ligand 2 Homo sapiens 0-5 16503719-7 2006 Atorvastatin significantly reduced the production of epithelial neutrophil-activating peptide-78, interleukin-6, interleukin-8, and monocyte chemotactic protein-1 (p<0.001 to p<0.05) in a concentration-dependent manner without affecting basal production of interleukin-10, fibroblast growth factor, and granulocyte colony stimulating factor. Atorvastatin 0-12 C-C motif chemokine ligand 2 Homo sapiens 132-162 16360645-14 2006 In vitro studies confirmed that HC11 was more toxic than RM175 to fresh human hepatocytes and equitoxic to mithramycin. Plicamycin 107-118 C-C motif chemokine ligand 2 Homo sapiens 32-36 16246469-4 2006 However, both wild type meningococcal LOS and KDO(2)-lipid A, significantly up-regulated CD80, CD83 and CD86 and released significantly higher amounts of IL-12p70, IL-6, IL-10, TNFalpha, MCP-1, IP-10 and RANTES. Kdo2-lipid A 46-60 C-C motif chemokine ligand 2 Homo sapiens 187-192 16506510-3 2006 The results showed that the values of concentrations found in supernatants obtained after settling of the flocs for two of the dependent variables studied, filtrate chemical oxygen demand (CODf) and total organic carbon (TOC), were significantly influenced by both the FeCl3 and MCP1 doses at an error lower than 5%. ferric chloride 269-274 C-C motif chemokine ligand 2 Homo sapiens 279-283 16254033-5 2006 Donor treatment with bilirubin up-regulated mRNA expression of protective genes such as HO-1 and bcl-2 and suppressed proinflammatory and proapoptotic genes including monocyte chemoattractant protein-1 and caspase-3 and -8 in the islet grafts before transplantation. Bilirubin 21-30 C-C motif chemokine ligand 2 Homo sapiens 167-201 16413542-2 2006 The present study describes the inhibition of MCP-1 (CCL2) and MIP-1alpha (CCL3) release by human monocyte-derived dendritic cells in response to adenine nucleotides. Adenine Nucleotides 146-165 C-C motif chemokine ligand 2 Homo sapiens 46-51 16413542-2 2006 The present study describes the inhibition of MCP-1 (CCL2) and MIP-1alpha (CCL3) release by human monocyte-derived dendritic cells in response to adenine nucleotides. Adenine Nucleotides 146-165 C-C motif chemokine ligand 2 Homo sapiens 53-57 16317058-8 2006 In addition, DHT inhibited mRNA expression of IL-6, MCP-1, CD40, TLR4, PAI-1, and Cox-2 and the release of cytokines and chemokines such as GRO, granulocyte-macrophage colony-stimulating factor, and TNF. Dihydrotestosterone 13-16 C-C motif chemokine ligand 2 Homo sapiens 52-57 16474202-4 2006 Increased HO-1 induction by hemin resulted in a significant decrease in the Lyso-PC-mediated induction of MCP-1 mRNA expression. Hemin 28-33 C-C motif chemokine ligand 2 Homo sapiens 106-111 16474202-4 2006 Increased HO-1 induction by hemin resulted in a significant decrease in the Lyso-PC-mediated induction of MCP-1 mRNA expression. Lysophosphatidylcholines 76-83 C-C motif chemokine ligand 2 Homo sapiens 106-111 16474202-5 2006 SnPP (IX), the specific inhibitor of HO-1 enzymatic activity, prevented the hemin-mediated attenuation of MCP-1 mRNA expression. S-Nitroso-N-propionyl-D,L-penicillamine 0-4 C-C motif chemokine ligand 2 Homo sapiens 106-111 16474202-5 2006 SnPP (IX), the specific inhibitor of HO-1 enzymatic activity, prevented the hemin-mediated attenuation of MCP-1 mRNA expression. Hemin 76-81 C-C motif chemokine ligand 2 Homo sapiens 106-111 16427785-11 2006 Piceatannol-a specific blocker of STAT3 phosphorylation-inhibited CT-1 induced MCP-1 induction completely. 3,3',4,5'-tetrahydroxystilbene 0-11 C-C motif chemokine ligand 2 Homo sapiens 79-84 16518329-8 2006 Mannitol caused a similar increase in PKC and NF-kappaB activation and MCP-1 synthesis. Mannitol 0-8 C-C motif chemokine ligand 2 Homo sapiens 71-76 16518329-9 2006 Prednisolone increased I-kappaB-alpha expression and inhibited glucose/mannitol-induced NF-kappaB DNA binding and MCP-1 expression without affecting PKC phosphorylation. Prednisolone 0-12 C-C motif chemokine ligand 2 Homo sapiens 114-119 16518329-9 2006 Prednisolone increased I-kappaB-alpha expression and inhibited glucose/mannitol-induced NF-kappaB DNA binding and MCP-1 expression without affecting PKC phosphorylation. Glucose 63-70 C-C motif chemokine ligand 2 Homo sapiens 114-119 16518329-9 2006 Prednisolone increased I-kappaB-alpha expression and inhibited glucose/mannitol-induced NF-kappaB DNA binding and MCP-1 expression without affecting PKC phosphorylation. Mannitol 71-79 C-C motif chemokine ligand 2 Homo sapiens 114-119 16518329-10 2006 The inhibitory effects of prednisolone on MCP-1 expression were reversed by mifepristone, a glucocorticoid receptor antagonist. Prednisolone 26-38 C-C motif chemokine ligand 2 Homo sapiens 42-47 16518329-10 2006 The inhibitory effects of prednisolone on MCP-1 expression were reversed by mifepristone, a glucocorticoid receptor antagonist. Mifepristone 76-88 C-C motif chemokine ligand 2 Homo sapiens 42-47 16518329-11 2006 Our results indicate that glucose induces MCP-1 mainly through hyperosmolarity by activating PKC and its downstream NF-kappaB, and that such effect was inhibited by prednisolone, suggesting the efficacy of prednisolone in preventing peritoneal fibrosis in patients on CAPD. Glucose 26-33 C-C motif chemokine ligand 2 Homo sapiens 42-47 16518329-11 2006 Our results indicate that glucose induces MCP-1 mainly through hyperosmolarity by activating PKC and its downstream NF-kappaB, and that such effect was inhibited by prednisolone, suggesting the efficacy of prednisolone in preventing peritoneal fibrosis in patients on CAPD. Prednisolone 206-218 C-C motif chemokine ligand 2 Homo sapiens 42-47 16393986-8 2006 In addition, PTX-B inhibited the secretion of IL-6-induced, AP-1-dependent genes, including urokinase-type plasminogen activator, CXCL8/IL-8, and CCL2/monocyte chemotactic protein-1. pumiliotoxin B 13-18 C-C motif chemokine ligand 2 Homo sapiens 146-150 16393986-8 2006 In addition, PTX-B inhibited the secretion of IL-6-induced, AP-1-dependent genes, including urokinase-type plasminogen activator, CXCL8/IL-8, and CCL2/monocyte chemotactic protein-1. pumiliotoxin B 13-18 C-C motif chemokine ligand 2 Homo sapiens 151-181 16518329-0 2006 Prednisolone inhibits hyperosmolarity-induced expression of MCP-1 via NF-kappaB in peritoneal mesothelial cells. Prednisolone 0-12 C-C motif chemokine ligand 2 Homo sapiens 60-65 16518329-2 2006 We investigated the cellular mechanism of high-glucose-induced expression of monocyte chemoattractant protein-1 (MCP-1), which is important in recruiting monocytes into the peritoneum and progression of peritoneal fibrosis, and examined the inhibitory mechanism of glucocorticoids. Glucose 47-54 C-C motif chemokine ligand 2 Homo sapiens 77-111 16518329-2 2006 We investigated the cellular mechanism of high-glucose-induced expression of monocyte chemoattractant protein-1 (MCP-1), which is important in recruiting monocytes into the peritoneum and progression of peritoneal fibrosis, and examined the inhibitory mechanism of glucocorticoids. Glucose 47-54 C-C motif chemokine ligand 2 Homo sapiens 113-118 16518329-6 2006 High glucose increased MCP-1 mRNA and MCP-1 protein expression. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 23-28 16518329-6 2006 High glucose increased MCP-1 mRNA and MCP-1 protein expression. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 38-43 16518329-7 2006 Although glucose increased phosphorylation of MEK1/2, p42/44 MAPK, p38 MAPK, JNK1/2, and PKC, and DNA-binding activity of NF-kappaB, its effect on MCP-1 expression was suppressed only by PKC and NF-kappaB inhibitors. Glucose 9-16 C-C motif chemokine ligand 2 Homo sapiens 147-152 16206161-0 2006 HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines. Opiate Alkaloids 14-20 C-C motif chemokine ligand 2 Homo sapiens 109-114 16206161-9 2006 Glia displayed increased MOR and MCP-1 immunoreactivity after morphine and/or Tat exposure. Morphine 62-70 C-C motif chemokine ligand 2 Homo sapiens 33-38 16183151-27 2006 Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes. Homocysteine 0-12 C-C motif chemokine ligand 2 Homo sapiens 50-84 16427785-13 2006 Parthenolide-a blocker of NFkappaB-inhibited CT-1 induced MCP-1 expression, completely. parthenolide 0-12 C-C motif chemokine ligand 2 Homo sapiens 58-63 16368293-10 2006 Monocyte chemoattractant protein-1 expression was lower and soluble IL-1 receptor antagonist expression higher in the MTX than placebo group (n = 32). Methotrexate 118-121 C-C motif chemokine ligand 2 Homo sapiens 0-34 16385517-7 2006 RESULTS: The glycosaminoglycan chondroitin sulfate, but not fibronectin or collagens, bound and released MCP-1 in a time-dependent manner. Glycosaminoglycans 13-30 C-C motif chemokine ligand 2 Homo sapiens 105-110 17192125-6 2006 In the EUTOPIA (EUropean Trial on Olmesartan and Pravastatin in Inflammation and Atherosclerosis) trial, olmesartan medoxomil significantly reduced serum levels of high-sensitivity C-reactive protein, high-sensitivity TNFalpha, IL-6, and MCP-1, all of which are involved in promoting atherosclerosis. olmesartan 105-115 C-C motif chemokine ligand 2 Homo sapiens 238-243 17192125-6 2006 In the EUTOPIA (EUropean Trial on Olmesartan and Pravastatin in Inflammation and Atherosclerosis) trial, olmesartan medoxomil significantly reduced serum levels of high-sensitivity C-reactive protein, high-sensitivity TNFalpha, IL-6, and MCP-1, all of which are involved in promoting atherosclerosis. medoxomil 116-125 C-C motif chemokine ligand 2 Homo sapiens 238-243 17192125-7 2006 In a monkey atherosclerotic model, a 3-D intravascular ultrasound analysis of aortas showed that serum levels of MCP-1 and the degree of intimal hyperplasia were significantly lower after treatment with olmesartan medoxomil than before treatment. Olmesartan Medoxomil 203-223 C-C motif chemokine ligand 2 Homo sapiens 113-118 16461197-6 2006 RESULTS: Compared to salt-resistant patients, salt-sensitive hypertensives showed age-adjusted increased levels of p-selectin (P = .006), e-selectin (P = .042), and MCP-1 (P = .036), although differences in e-selectin were not maintained after adjustment for BP values. Salts 46-50 C-C motif chemokine ligand 2 Homo sapiens 165-170 16385517-7 2006 RESULTS: The glycosaminoglycan chondroitin sulfate, but not fibronectin or collagens, bound and released MCP-1 in a time-dependent manner. Chondroitin Sulfates 31-50 C-C motif chemokine ligand 2 Homo sapiens 105-110 16385517-8 2006 MCP-1 that was released from chondroitin sulfate induced the differentiation of interleukin-4 (IL-4)-producing T cells in a dose-dependent manner. Chondroitin Sulfates 29-48 C-C motif chemokine ligand 2 Homo sapiens 0-5 16845898-4 2006 Hcy treatment (100 micromol/L) resulted in NF-kappaB activation and increased monocyte chemoattractant protein-1 (MCP-1) expression in THP-1 derived macrophages. Homocysteine 0-3 C-C motif chemokine ligand 2 Homo sapiens 78-112 16845898-4 2006 Hcy treatment (100 micromol/L) resulted in NF-kappaB activation and increased monocyte chemoattractant protein-1 (MCP-1) expression in THP-1 derived macrophages. Homocysteine 0-3 C-C motif chemokine ligand 2 Homo sapiens 114-119 16845898-8 2006 Consequently, Hcy-induced NF-kappaB activation and MCP-1 expression was inhibited. Homocysteine 14-17 C-C motif chemokine ligand 2 Homo sapiens 51-56 16340663-4 2006 Experimental studies suggest that uric acid induce its detrimental effects at the cellular level entering to vascular smooth muscle cells (VSMC) via an organic anion transport system, and followed by the activation of specific MAP kinases, nuclear transcription factors, with stimulation of COX-2, PDGF A and C chain, PDGF alpha receptor, and various inflammatory mediators, including C-reactive protein and monocyte chemoattractant protein-1. Uric Acid 34-43 C-C motif chemokine ligand 2 Homo sapiens 408-442 18200777-3 2006 Nifedipine inhibited MCP-1 expression by inhibiting nuclear factor (NF)-kappaB activation. Nifedipine 0-10 C-C motif chemokine ligand 2 Homo sapiens 21-26 16454704-14 2006 Therefore, as an inhibitor of CCL2, glycyrrhizin protects individuals infected with S. aureus. Glycyrrhizic Acid 36-48 C-C motif chemokine ligand 2 Homo sapiens 30-34 16809218-0 2006 Doxycycline decreases monocyte chemoattractant protein-1 in human lung epithelial cells. Doxycycline 0-11 C-C motif chemokine ligand 2 Homo sapiens 22-56 16809218-4 2006 The authors hypothesized that doxycycline exerts its anti-inflammatory effects, in part, by reducing MCP-1 production. Doxycycline 30-41 C-C motif chemokine ligand 2 Homo sapiens 101-106 16809218-6 2006 In stimulated cells doxycycline decreased MCP-1 production by 95% and in monocyte chemotaxis assays migration decreased by 55%. Doxycycline 20-31 C-C motif chemokine ligand 2 Homo sapiens 42-47 16809218-7 2006 However, doxycycline did decrease expression of MCP-1 mRNA and did not effect its stability. Doxycycline 9-20 C-C motif chemokine ligand 2 Homo sapiens 48-53 16809218-8 2006 These data demonstrate that doxycycline modulates MCP-1 production and suggest that doxycycline may provide a new anti-inflammatory therapy for chronic lung diseases. Doxycycline 28-39 C-C motif chemokine ligand 2 Homo sapiens 50-55 16897233-0 2006 Effects of sivelestat, a new elastase inhibitor, on IL-8 and MCP-1 production from stimulated human alveolar epithelial type II cells. sivelestat 11-21 C-C motif chemokine ligand 2 Homo sapiens 61-66 16775385-8 2006 Most importantly, administration of the COX-2 inhibitor NS-398 attenuated Tat-mediated upregulation of mRNA and protein expression of inflammatory mediators, such as monocyte chemoattractant protein-1, interleukin-1beta, tumor necrosis factor-alpha, and inducible nitric oxide synthase. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 56-62 C-C motif chemokine ligand 2 Homo sapiens 166-200 15942931-3 2006 After oxidation to form the two-disulfide bonds, affinity chromatography using an immobilized mouse anti-human MCP-1 monoclonal antibody (mAb) was utilized for a simple and highly effective purification procedure for the proteins. Disulfides 32-41 C-C motif chemokine ligand 2 Homo sapiens 111-116 16636588-10 2006 Silymarin dose-dependently inhibited the TNF-alpha- or IL-1beta-induced NF-kappaB activation and MCP-1 expression. Silymarin 0-9 C-C motif chemokine ligand 2 Homo sapiens 97-102 16085694-10 2006 MCP-1 stimulated COX-2 expression and PGE(2) and VEGF release in human macrophages. Prostaglandins E 38-41 C-C motif chemokine ligand 2 Homo sapiens 0-5 16085694-11 2006 Celecoxib, a selective COX-2 inhibitor, inhibited MCP-1-induced PGE(2) and VEGF release in macrophages. Celecoxib 0-9 C-C motif chemokine ligand 2 Homo sapiens 50-55 16085694-11 2006 Celecoxib, a selective COX-2 inhibitor, inhibited MCP-1-induced PGE(2) and VEGF release in macrophages. Prostaglandins E 64-67 C-C motif chemokine ligand 2 Homo sapiens 50-55 16244112-9 2006 These results show that the combination of CRP and ox-LDL can cause a synergistic enhancement of the role of monocytes in inflammation, first, by increasing MCP-1, which attracts more monocytes and directly enhances MMP-1 production by activated monocytes, and second, by elevating PGE2 production, which also leads to higher levels of MMP-1. Dinoprostone 282-286 C-C motif chemokine ligand 2 Homo sapiens 157-162 17191019-0 2006 Inhibitory effect of quercetin on tryptase and MCP-1 chemokine release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line. Quercetin 21-30 C-C motif chemokine ligand 2 Homo sapiens 47-52 16617734-7 2006 RESULTS: The concentration of sPECAM-l and MCP-1 in cerebrospinal fluid of TBE patients was significantly increased in comparison with the. tbe 75-78 C-C motif chemokine ligand 2 Homo sapiens 43-48 17191019-5 2006 In this study quercetin inhibits, in a dose-response manner, tryptase and MCP-1. Quercetin 14-23 C-C motif chemokine ligand 2 Homo sapiens 74-79 17191019-6 2006 Moreover, using RT-PCR quercetin inhibited the transcription of histidine decarboxylase, the rate-limiting enzyme responsible for the generation of histamine from histidine, and MCP-1. Quercetin 23-32 C-C motif chemokine ligand 2 Homo sapiens 178-183 16391493-0 2006 Effect of berberine on interleukin 8 and monocyte chemotactic protein 1 expression in a human retinal pigment epithelial cell line. Berberine 10-19 C-C motif chemokine ligand 2 Homo sapiens 41-71 16391493-1 2006 PURPOSE: The aims of this study were to examine the effects of berberine, an alkaloid isolated from some medicinal herbs, on interleukin 8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) expression in a human retinal pigment epithelial cell line (ARPE-19) stimulated with interleukin 1beta (IL-1beta) or tumor necrosis factor alpha (TNF-alpha). Berberine 63-72 C-C motif chemokine ligand 2 Homo sapiens 150-180 16391493-1 2006 PURPOSE: The aims of this study were to examine the effects of berberine, an alkaloid isolated from some medicinal herbs, on interleukin 8 (IL-8) and monocyte chemotactic protein 1 (MCP-1) expression in a human retinal pigment epithelial cell line (ARPE-19) stimulated with interleukin 1beta (IL-1beta) or tumor necrosis factor alpha (TNF-alpha). Berberine 63-72 C-C motif chemokine ligand 2 Homo sapiens 182-187 16391493-7 2006 CONCLUSION: These findings indicate that berberine dose-dependently inhibited the expression of IL-8 and MCP-1 induced by IL-1beta or TNF-alpha. Berberine 41-50 C-C motif chemokine ligand 2 Homo sapiens 105-110 16617734-11 2006 The increased concentration of MCP-1 seems to be an essential event in the pathomechanism of inflammation in the central nervous system in TBE. tbe 139-142 C-C motif chemokine ligand 2 Homo sapiens 31-36 16617734-12 2006 It would be valuable in clinical conditions to search for the methods of inhibition of the increased expression of sPECAM-1 and MCP-1 in TBE to diminish the inflammatory reaction. tbe 137-140 C-C motif chemokine ligand 2 Homo sapiens 128-133 16328410-4 2005 Actinomycin D (1 mug/ml for 24 h) pre-treatment of the F-spheroids abolished the monocyte MCP-1 co-culture response. Dactinomycin 0-13 C-C motif chemokine ligand 2 Homo sapiens 90-95 16423198-5 2006 RESULTS: Serum hs-CRP, TF, MCP-1 and Hsp-70 levels were significantly higher in OSAHS compared with control subjects. osahs 80-85 C-C motif chemokine ligand 2 Homo sapiens 27-32 16423198-7 2006 The hs-CRP, TF, MCP-1 and Hsp-70 levels in the non-obese OSAHS group were also significantly higher than those in the control group whereas there was no difference in BMI between the two groups. osahs 57-62 C-C motif chemokine ligand 2 Homo sapiens 16-21 16543969-5 2006 17beta-dihydroequilenin and 17beta-estradiol at a concentration of 1 microM reduced IL-1alpha-induced up regulation of IL-6, IL-8 and MCP-1 close to control levels. 17-dihydroequilenin 0-23 C-C motif chemokine ligand 2 Homo sapiens 134-139 16543969-5 2006 17beta-dihydroequilenin and 17beta-estradiol at a concentration of 1 microM reduced IL-1alpha-induced up regulation of IL-6, IL-8 and MCP-1 close to control levels. Estradiol 28-44 C-C motif chemokine ligand 2 Homo sapiens 134-139 16543969-8 2006 The effect of 17beta-dihydroequilenin on IL-1alpha-induced production of IL-6, IL-8 and MCP-1 was reversed by the estrogen receptor antagonist ICI 182,780. 17-dihydroequilenin 14-37 C-C motif chemokine ligand 2 Homo sapiens 88-93 16266385-6 2005 A single dose of nasal budesonide caused a decrease in symptoms (P < 0.05) and nasal eosinophils (P < 0.05) with selective abrogation of IL-5 and IL-13 responses (P < 0.05), but a lack of effect on levels of eotaxin, RANTES, IL-8 and MCP-1. Budesonide 23-33 C-C motif chemokine ligand 2 Homo sapiens 243-248 16284287-3 2005 AIM: We examined the effect of human dominant negative inhibitor of MCP-1 (mutant MCP-1) on progression of chronic pancreatitis induced by DBTC in a rat model. dibutyldichlorotin 139-143 C-C motif chemokine ligand 2 Homo sapiens 82-87 16181613-9 2005 RT-PCR results showed that honokiol suppressed NF-kappaB-regulated inflammatory and carcinogenic gene products including MMP-9, TNF-alpha, IL-8, ICAM-1 and MCP-1. honokiol 27-35 C-C motif chemokine ligand 2 Homo sapiens 156-161 16337471-6 2005 The production of IL-8 and monocyte chemoattractant protein 1 in response to either IgE alone or IgE and anti-IgE was enhanced by preincubation of the cells in IL-4 and was inhibited by preincubation of the cells with dexamethasone. Dexamethasone 218-231 C-C motif chemokine ligand 2 Homo sapiens 27-61 16306213-7 2005 The magnitude of induction of MCP-1, CCR2, and iNOS or in combinations correlated positively with serum high-sensitivity C-reactive protein (hs-CRP), and low-density lipoprotein (LDL) cholesterol levels and negatively with high-density lipoprotein (HDL) cholesterol level. Cholesterol 184-195 C-C motif chemokine ligand 2 Homo sapiens 30-35 16306213-7 2005 The magnitude of induction of MCP-1, CCR2, and iNOS or in combinations correlated positively with serum high-sensitivity C-reactive protein (hs-CRP), and low-density lipoprotein (LDL) cholesterol levels and negatively with high-density lipoprotein (HDL) cholesterol level. Cholesterol 254-265 C-C motif chemokine ligand 2 Homo sapiens 30-35 16358608-10 2005 Curcumin (AP-1 inhibitor) markedly suppressed the TNF-alpha-induced CCL2 expression. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 68-72 16253226-8 2005 TNF-alpha-induced monocyte chemoattractant protein-1 (MCP-1) expression was also attenuated by addition of PGG. beta-penta-O-galloyl-glucose 107-110 C-C motif chemokine ligand 2 Homo sapiens 18-52 16253226-8 2005 TNF-alpha-induced monocyte chemoattractant protein-1 (MCP-1) expression was also attenuated by addition of PGG. beta-penta-O-galloyl-glucose 107-110 C-C motif chemokine ligand 2 Homo sapiens 54-59 16214031-6 2005 The results indicate that cholesterol may contribute to the progression of atherosclerotic lesions by strongly up-regulating crucial proinflammatory factors like MCP-1, but only after having been oxidized to oxysterols. Cholesterol 26-37 C-C motif chemokine ligand 2 Homo sapiens 162-167 16203870-6 2005 On the other hand, monocyte chemoattractant protein-1 and malondialdehyde-modified LDL were significantly higher in the placebo-treated group than in the normal group, whereas they were suppressed in the eplerenone-treated groups. Eplerenone 204-214 C-C motif chemokine ligand 2 Homo sapiens 19-53 16214031-0 2005 Oxysterol-induced up-regulation of MCP-1 expression and synthesis in macrophage cells. Oxysterols 0-9 C-C motif chemokine ligand 2 Homo sapiens 35-40 16214031-5 2005 Up-regulated expression and synthesis of MCP-1 by the oxysterol mixture was clearly dependent on a net increment of phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and nuclear factor kappaB (NF-kappaB) nuclear binding. Oxysterols 54-63 C-C motif chemokine ligand 2 Homo sapiens 41-46 16221210-11 2005 The nuclear factor-kappaB (NF-kappaB) inhibitors N-acetyl-L-cysteine (NAC) and pyrrolidinecarbodithioic acid (PDTC) effectively blocked fibronectin induction of MCP-1 mRNA. prolinedithiocarbamate 110-114 C-C motif chemokine ligand 2 Homo sapiens 161-166 16221210-7 2005 Src tyrosine kinases were involved in the fibronectin activation of MCP-1 since the Src inhibitors SU6656 and PP2 effectively reduced the induction of this chemokine. SU 6656 99-105 C-C motif chemokine ligand 2 Homo sapiens 68-73 16221210-9 2005 The ERK kinase (MEK1/2) inhibitor U0126 inhibited the fibronectin induction of MCP-1 mRNA suggesting that ERK1/2 was also involved in this inflammatory pathway. U 0126 34-39 C-C motif chemokine ligand 2 Homo sapiens 79-84 16221210-11 2005 The nuclear factor-kappaB (NF-kappaB) inhibitors N-acetyl-L-cysteine (NAC) and pyrrolidinecarbodithioic acid (PDTC) effectively blocked fibronectin induction of MCP-1 mRNA. prolinedithiocarbamate 79-108 C-C motif chemokine ligand 2 Homo sapiens 161-166 15950427-2 2005 Particulate wear debris induced NF-kappaB activation, the major transcriptional regulator of IL-8 and MCP-1 pro-inflammatory genes and, indeed, both IL-8 and MCP-1 chemokine gene expressions were upregulated in titanium particulate-stimulated human osteoblasts. Titanium 211-219 C-C motif chemokine ligand 2 Homo sapiens 102-107 15950427-2 2005 Particulate wear debris induced NF-kappaB activation, the major transcriptional regulator of IL-8 and MCP-1 pro-inflammatory genes and, indeed, both IL-8 and MCP-1 chemokine gene expressions were upregulated in titanium particulate-stimulated human osteoblasts. Titanium 211-219 C-C motif chemokine ligand 2 Homo sapiens 158-163 16155367-9 2005 The two new PPAR-gamma agonists and 15d-PGJ2 also inhibited TNF-alpha-induced interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) production in supernatants of TNF-alpha-stimulated ECs, whereas ciglitazone and DIM-C-pPhCH(3) did not decrease TNF-alpha-induced expression of these two proteins. 15-deoxy-delta(12,14)-prostaglandin J2 36-44 C-C motif chemokine ligand 2 Homo sapiens 103-137 16155367-9 2005 The two new PPAR-gamma agonists and 15d-PGJ2 also inhibited TNF-alpha-induced interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) production in supernatants of TNF-alpha-stimulated ECs, whereas ciglitazone and DIM-C-pPhCH(3) did not decrease TNF-alpha-induced expression of these two proteins. 15-deoxy-delta(12,14)-prostaglandin J2 36-44 C-C motif chemokine ligand 2 Homo sapiens 139-144 16155367-9 2005 The two new PPAR-gamma agonists and 15d-PGJ2 also inhibited TNF-alpha-induced interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) production in supernatants of TNF-alpha-stimulated ECs, whereas ciglitazone and DIM-C-pPhCH(3) did not decrease TNF-alpha-induced expression of these two proteins. ciglitazone 210-221 C-C motif chemokine ligand 2 Homo sapiens 139-144 16155367-9 2005 The two new PPAR-gamma agonists and 15d-PGJ2 also inhibited TNF-alpha-induced interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) production in supernatants of TNF-alpha-stimulated ECs, whereas ciglitazone and DIM-C-pPhCH(3) did not decrease TNF-alpha-induced expression of these two proteins. dim-c-pphch 226-237 C-C motif chemokine ligand 2 Homo sapiens 139-144 15908470-5 2005 In addition, EtOH significantly reduced NF-kappaB and AP-1 binding activity induced by IL-1beta and inhibited MCP-1 gene transcription. Ethanol 13-17 C-C motif chemokine ligand 2 Homo sapiens 110-115 16105652-6 2005 Desferrioxamine mimicked hypoxia in the reduction of MCP-1 expression. Deferoxamine 0-15 C-C motif chemokine ligand 2 Homo sapiens 53-58 16270277-4 2005 By signalling to the nucleus, the aldehyde may up-regulate in these cells both expression and synthesis of monocyte chemotactic protein 1 (MCP-1) and transforming growth factor beta1 (TGFbeta1). Aldehydes 34-42 C-C motif chemokine ligand 2 Homo sapiens 107-137 16270277-4 2005 By signalling to the nucleus, the aldehyde may up-regulate in these cells both expression and synthesis of monocyte chemotactic protein 1 (MCP-1) and transforming growth factor beta1 (TGFbeta1). Aldehydes 34-42 C-C motif chemokine ligand 2 Homo sapiens 139-144 16270277-6 2005 As for HNE, the challenge of cells of the macrophage lineage with a mixture of oxysterols like that detectable in hypercholesterolemic individuals led to a marked overexpression of TGFbeta1 and MCP-1. Oxysterols 79-89 C-C motif chemokine ligand 2 Homo sapiens 194-199 16210650-3 2005 We now report that LPA potently induces the generation of proinflammatory chemokines (MIP-1beta, IL-8, and MCP-1) by hMCs by a mechanism that absolutely requires IL-4. lysophosphatidic acid 19-22 C-C motif chemokine ligand 2 Homo sapiens 107-112 16105652-4 2005 Treatment with actinomycin D showed that hypoxic down-regulation of MCP-1 expression resulted mainly from a decrease in the transcription but not the mRNA stability. Dactinomycin 15-28 C-C motif chemokine ligand 2 Homo sapiens 68-73 15908470-0 2005 Ethanol inhibits monocyte chemotactic protein-1 expression in interleukin-1{beta}-activated human endothelial cells. Ethanol 0-7 C-C motif chemokine ligand 2 Homo sapiens 17-47 15908470-1 2005 The aim of this study was to determine the effect of ethanol (EtOH) on endothelial monocyte chemotactic protein-1 (MCP-1) expression. Ethanol 53-60 C-C motif chemokine ligand 2 Homo sapiens 83-113 15908470-1 2005 The aim of this study was to determine the effect of ethanol (EtOH) on endothelial monocyte chemotactic protein-1 (MCP-1) expression. Ethanol 53-60 C-C motif chemokine ligand 2 Homo sapiens 115-120 15908470-1 2005 The aim of this study was to determine the effect of ethanol (EtOH) on endothelial monocyte chemotactic protein-1 (MCP-1) expression. Ethanol 62-66 C-C motif chemokine ligand 2 Homo sapiens 83-113 15908470-7 2005 Modulation of the expression of MCP-1 represents a mechanism whereby EtOH could inhibit atherogenesis by blocking the crucial early step of monocyte adhesion and subsequent recruitment to the subendothelial space. Ethanol 69-73 C-C motif chemokine ligand 2 Homo sapiens 32-37 15908470-1 2005 The aim of this study was to determine the effect of ethanol (EtOH) on endothelial monocyte chemotactic protein-1 (MCP-1) expression. Ethanol 62-66 C-C motif chemokine ligand 2 Homo sapiens 115-120 15908470-2 2005 IL-1beta increased the production of MCP-1 by human umbilical vein endothelial cells from undetectable levels to approximately 900 pg/ml at 24 h. EtOH dose-dependently inhibited IL-1beta-stimulated MCP-1 secretion as determined by ELISA: 25 +/- 1%, 35 +/- 7%, and 65 +/- 5% inhibition for 1, 10, and 100 mM EtOH, respectively, concomitant with inhibition of monocyte adhesion to activated endothelial cells. Ethanol 146-150 C-C motif chemokine ligand 2 Homo sapiens 37-42 16164630-0 2005 Parenteral iron treatment induces MCP-1 accumulation in plasma, normal kidneys, and in experimental nephropathy. Iron 11-15 C-C motif chemokine ligand 2 Homo sapiens 34-39 15908470-2 2005 IL-1beta increased the production of MCP-1 by human umbilical vein endothelial cells from undetectable levels to approximately 900 pg/ml at 24 h. EtOH dose-dependently inhibited IL-1beta-stimulated MCP-1 secretion as determined by ELISA: 25 +/- 1%, 35 +/- 7%, and 65 +/- 5% inhibition for 1, 10, and 100 mM EtOH, respectively, concomitant with inhibition of monocyte adhesion to activated endothelial cells. Ethanol 146-150 C-C motif chemokine ligand 2 Homo sapiens 198-203 15908470-2 2005 IL-1beta increased the production of MCP-1 by human umbilical vein endothelial cells from undetectable levels to approximately 900 pg/ml at 24 h. EtOH dose-dependently inhibited IL-1beta-stimulated MCP-1 secretion as determined by ELISA: 25 +/- 1%, 35 +/- 7%, and 65 +/- 5% inhibition for 1, 10, and 100 mM EtOH, respectively, concomitant with inhibition of monocyte adhesion to activated endothelial cells. Ethanol 307-311 C-C motif chemokine ligand 2 Homo sapiens 37-42 15908470-3 2005 Similarly, EtOH dose-dependently inhibited IL-1beta-stimulated MCP-1 mRNA expression. Ethanol 11-15 C-C motif chemokine ligand 2 Homo sapiens 63-68 15908470-4 2005 Experiments with actinomycin D demonstrated that EtOH decreased the stability of MCP-1 mRNA. Dactinomycin 17-30 C-C motif chemokine ligand 2 Homo sapiens 81-86 15908470-4 2005 Experiments with actinomycin D demonstrated that EtOH decreased the stability of MCP-1 mRNA. Ethanol 49-53 C-C motif chemokine ligand 2 Homo sapiens 81-86 16186362-7 2005 SP600125, a specific pharmacologic inhibitor of JNK, blocked MCP-1 but not IL-8 mRNA and protein expression. pyrazolanthrone 0-8 C-C motif chemokine ligand 2 Homo sapiens 61-66 16172181-7 2005 Monocyte chemoattractant protein 1 values were higher in patients with greater delays in N-acetylcysteine treatment and in patients with higher values of prothrombin time. Acetylcysteine 89-105 C-C motif chemokine ligand 2 Homo sapiens 0-34 16172181-8 2005 Monocyte chemoattractant protein 1 elevation in acetaminophen overdose may represent an innate, immunomodulary response of the liver to earlier events in the toxicity. Acetaminophen 48-61 C-C motif chemokine ligand 2 Homo sapiens 0-34 16174288-6 2005 NF-kappaB-MCP-1 pathway is activated by ROS and promotes monocyte recruitment and profibrotic process in the kidney. Reactive Oxygen Species 40-43 C-C motif chemokine ligand 2 Homo sapiens 10-15 16309586-4 2005 Glucose and heme increased both 8-epi-PGF2alpha and MCP-1. Glucose 0-7 C-C motif chemokine ligand 2 Homo sapiens 52-57 16309586-4 2005 Glucose and heme increased both 8-epi-PGF2alpha and MCP-1. Heme 12-16 C-C motif chemokine ligand 2 Homo sapiens 52-57 16164630-3 2005 Thus, this study tested whether pro-oxidant iron/carbohydrate complexes, used to treat iron deficiency, induce MCP-1 in renal/extrarenal tissues, in plasma, and in the setting of experimental nephropathy. Iron 44-48 C-C motif chemokine ligand 2 Homo sapiens 111-116 16164630-3 2005 Thus, this study tested whether pro-oxidant iron/carbohydrate complexes, used to treat iron deficiency, induce MCP-1 in renal/extrarenal tissues, in plasma, and in the setting of experimental nephropathy. Carbohydrates 49-61 C-C motif chemokine ligand 2 Homo sapiens 111-116 16164630-6 2005 Iron effects on liver, lung, spleen, and heart MCP-1 mRNA, and on peritoneal lavage fluid MCP-1 concentrations were assessed. Iron 0-4 C-C motif chemokine ligand 2 Homo sapiens 47-52 16164630-7 2005 Iron pretreatment effects on MCP-1 levels in unilaterally obstructed kidneys vs. contralateral kidneys were determined. Iron 0-4 C-C motif chemokine ligand 2 Homo sapiens 29-34 16164630-8 2005 Finally, iron gluconate"s influence on proximal tubule [human kidney-2 (HK-2)] cell MCP-1 levels was assessed. ferrous gluconate 9-23 C-C motif chemokine ligand 2 Homo sapiens 84-89 16164630-9 2005 RESULTS: Iron sucrose (the primary test agent) markedly increased plasma and renal MCP-1 levels. Ferric Oxide, Saccharated 9-21 C-C motif chemokine ligand 2 Homo sapiens 83-88 16164630-12 2005 The iron dextran and iron sucrose-induced renal MCP-1 mRNA increments ( approximately 4x) were persistent, lasting for at least 3 to 7 days. Iron-Dextran Complex 4-16 C-C motif chemokine ligand 2 Homo sapiens 48-53 16164630-12 2005 The iron dextran and iron sucrose-induced renal MCP-1 mRNA increments ( approximately 4x) were persistent, lasting for at least 3 to 7 days. Ferric Oxide, Saccharated 21-33 C-C motif chemokine ligand 2 Homo sapiens 48-53 16164630-13 2005 Iron gluconate raised MCP-1 levels in peritoneal lavage fluid. ferrous gluconate 0-14 C-C motif chemokine ligand 2 Homo sapiens 22-27 16164630-15 2005 Iron gluconate raised HK-2 cell MCP-1, implying a direct proximal tubule effect. ferrous gluconate 0-14 C-C motif chemokine ligand 2 Homo sapiens 32-37 16164630-16 2005 CONCLUSION: Iron sucrose and iron gluconate (but not iron dextran) can induce MCP-1 generation in renal and extrarenal tissues, possibly via transcriptional events. Ferric Oxide, Saccharated 12-24 C-C motif chemokine ligand 2 Homo sapiens 78-83 16164630-16 2005 CONCLUSION: Iron sucrose and iron gluconate (but not iron dextran) can induce MCP-1 generation in renal and extrarenal tissues, possibly via transcriptional events. ferrous gluconate 29-43 C-C motif chemokine ligand 2 Homo sapiens 78-83 16164630-18 2005 Finally, iron can increase peritoneal lavage fluid MCP-1 levels. Iron 9-13 C-C motif chemokine ligand 2 Homo sapiens 51-56 16164450-0 2005 Cysteinyl leukotrienes induce monocyte chemoattractant protein 1 in human monocytes/macrophages. cysteinyl-leukotriene 0-22 C-C motif chemokine ligand 2 Homo sapiens 30-64 15829559-0 2005 Bidirectional regulation of monocyte chemoattractant protein-1 gene at distinct sites of its promoter by nitric oxide in vascular smooth muscle cells. Nitric Oxide 105-117 C-C motif chemokine ligand 2 Homo sapiens 28-62 15829559-2 2005 To examine the anti-inflammatory effect of nitric oxide (NO) on proinflammatory gene expression, we have investigated the effects of sodium nitroprusside (SNP) on the monocyte chemoattractant protein-1 (MCP-1) gene expression in VSMCs under chronic activation of PI3-kinase. Nitroprusside 133-153 C-C motif chemokine ligand 2 Homo sapiens 167-201 15829559-2 2005 To examine the anti-inflammatory effect of nitric oxide (NO) on proinflammatory gene expression, we have investigated the effects of sodium nitroprusside (SNP) on the monocyte chemoattractant protein-1 (MCP-1) gene expression in VSMCs under chronic activation of PI3-kinase. Nitroprusside 133-153 C-C motif chemokine ligand 2 Homo sapiens 203-208 16020745-4 2005 L-NAME also induced monocyte chemoattractant protein-1 (MCP-1) expression, which was blocked by an NO donor, NOC18. NG-Nitroarginine Methyl Ester 0-6 C-C motif chemokine ligand 2 Homo sapiens 20-54 16020745-4 2005 L-NAME also induced monocyte chemoattractant protein-1 (MCP-1) expression, which was blocked by an NO donor, NOC18. NG-Nitroarginine Methyl Ester 0-6 C-C motif chemokine ligand 2 Homo sapiens 56-61 16020745-5 2005 Exogenous MCP-1 enhanced TF expression induced by monocyte adhesion, whereas adenovirus-mediated expression of the mutant MCP-1, 7ND, abolished the L-NAME enhancement of TF expression induced by monocyte adhesion. NG-Nitroarginine Methyl Ester 148-154 C-C motif chemokine ligand 2 Homo sapiens 122-127 16020745-6 2005 Monocyte attachment to L-NAME-treated ECs increased Ca2+ influx, which was prevented by NOC18, anti-MCP-1 antibody or 7ND. NG-Nitroarginine Methyl Ester 23-29 C-C motif chemokine ligand 2 Homo sapiens 100-105 16164450-7 2005 Moreover, we demonstrated that pranlukast, a CysLT1 receptor antagonist, blocked MCP-1 production by CysLTs in THP-1 cells almost completely, and partially inhibited MCP-1 release by CysLTs in peripheral blood CD14+ monocytes/macrophages and CCR2B expression by CysLTs in THP-1 cells. pranlukast 31-41 C-C motif chemokine ligand 2 Homo sapiens 166-171 16116069-4 2005 Significant clinical correlates of MCP-1 levels were age, cigarette smoking, triglycerides, body mass index, and waist-to-hip ratio. Triglycerides 77-90 C-C motif chemokine ligand 2 Homo sapiens 35-40 16125534-0 2005 The effect of low-dose atorvastatin on circulating monocyte chemoattractant protein-1 in patients with type 2 diabetes complicated by hyperlipidemia. Atorvastatin 23-35 C-C motif chemokine ligand 2 Homo sapiens 51-85 16085045-3 2005 METHODS: Expression of MCP-1 was evaluated in the myometrium, the placenta, the gestational membranes (GM) and the amniotic fluid (AF) by real time RT-PCR, Northern blot analysis and ELISA. gm 103-105 C-C motif chemokine ligand 2 Homo sapiens 23-28 16085045-6 2005 Increased MCP-1 transcripts were demonstrated in GM during term labor. gm 49-51 C-C motif chemokine ligand 2 Homo sapiens 10-15 16143069-1 2005 AIM: To study the relationship between P38MAPK and MCP-1 in diabetic HUVEC and the mechanism of anti-atherosclerosis of selenium. Selenium 120-128 C-C motif chemokine ligand 2 Homo sapiens 51-56 16143069-4 2005 RESULTS: High concentration of glucose, AGE, high concentration of insulin and H(2)O(2) can activate P38MAPK and increase the expression of MCP-1 in HUVEC. Glucose 31-38 C-C motif chemokine ligand 2 Homo sapiens 140-145 16143069-5 2005 The expression of MCP-1 was inhibited by SB203580. SB 203580 41-49 C-C motif chemokine ligand 2 Homo sapiens 18-23 16143069-6 2005 Selenium inhibited the activation of P38MAPK and reduced the expression of MCP-1. Selenium 0-8 C-C motif chemokine ligand 2 Homo sapiens 75-80 16143069-9 2005 Selenium can inhibit the expression of MCP-1 by repressing P38MAPK signaling pathway and therefore prevent the development of atherosclerosis. Selenium 0-8 C-C motif chemokine ligand 2 Homo sapiens 39-44 16321206-11 2005 CONCLUSION: Mechanical stress induces the RPE cells to express MCP-1 and IL-8, and this effect was inhibited in part by pretreatment of CD, indicating that the cytoskeleton may be involved in the effect and that these two inflammatory cytokines take a part in the early stage of development of primary retinal detachment. Cytochalasin D 136-138 C-C motif chemokine ligand 2 Homo sapiens 63-68 16164276-11 2005 Finally, the minimum-free-energy path at 300 K for the addition of CCl2 to ethylene is compared with a path based on a simple one-dimensional reaction coordinate. ethylene 75-83 C-C motif chemokine ligand 2 Homo sapiens 67-71 16033640-8 2005 Additionally, we localized the CCL2 and CXCL10 mRNAs in human lung tissue explants by in situ hybridization, and demonstrated the selective effects of cytokines and dexamethasone on CCL2 and CXCL10 expression. Dexamethasone 165-178 C-C motif chemokine ligand 2 Homo sapiens 182-186 16046295-0 2005 Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone. Pioglitazone 178-190 C-C motif chemokine ligand 2 Homo sapiens 23-59 16046295-7 2005 Pioglitazone increased S(I) by 60% and in the same subjects reduced both CD68 and MCP-1 mRNAs by >50%. Pioglitazone 0-12 C-C motif chemokine ligand 2 Homo sapiens 82-87 16046295-10 2005 Thus, treatment with pioglitazone reduces expression of CD68 and MCP-1 in adipose tissue, apparently by reducing macrophage numbers, resulting in reduced inflammatory cytokine production and improvement in S(I). Pioglitazone 21-33 C-C motif chemokine ligand 2 Homo sapiens 65-70 16273763-16 2005 Both BD patients and disease controls with acute thrombosis had significantly higher levels of MCP-1 as compared to corresponding chronic thrombosis patients (BD-AT vs. DC-CT; p < 0.001; DC-AT vs. DC-CT, p < 0.001). bd-at 159-164 C-C motif chemokine ligand 2 Homo sapiens 95-100 16273763-16 2005 Both BD patients and disease controls with acute thrombosis had significantly higher levels of MCP-1 as compared to corresponding chronic thrombosis patients (BD-AT vs. DC-CT; p < 0.001; DC-AT vs. DC-CT, p < 0.001). dc-at 190-195 C-C motif chemokine ligand 2 Homo sapiens 95-100 16273763-16 2005 Both BD patients and disease controls with acute thrombosis had significantly higher levels of MCP-1 as compared to corresponding chronic thrombosis patients (BD-AT vs. DC-CT; p < 0.001; DC-AT vs. DC-CT, p < 0.001). dc-ct 200-205 C-C motif chemokine ligand 2 Homo sapiens 95-100 15980221-6 2005 RESULTS: Both triptolide and dexamethasone inhibited in a dose-dependent manner the expression of IL-8 and MCP-1 in corneal fibroblasts induced by the proinflammatory cytokines IL-1beta or tumor necrosis factor (TNF)-alpha. triptolide 14-24 C-C motif chemokine ligand 2 Homo sapiens 107-112 15935590-5 2005 After 1 month of therapy with AchEI (Donepezil), MCP-1 levels increased in each patient. Donepezil 37-46 C-C motif chemokine ligand 2 Homo sapiens 49-54 16034720-7 2005 On a transcriptional level, mRNA of the proinflammatory adipokines leptin and monocyte chemoattractant protein-1 (MCP-1) was increased by 5,000% and 40%, respectively, by aldosterone exposure (p < 0.05). Aldosterone 171-182 C-C motif chemokine ligand 2 Homo sapiens 78-112 16034720-7 2005 On a transcriptional level, mRNA of the proinflammatory adipokines leptin and monocyte chemoattractant protein-1 (MCP-1) was increased by 5,000% and 40%, respectively, by aldosterone exposure (p < 0.05). Aldosterone 171-182 C-C motif chemokine ligand 2 Homo sapiens 114-119 15983321-10 2005 Markers of oxidative stress (serum malondialdehyde, fluorescent products of lipid peroxidation, monocyte chemoattractant protein-1, and 8-isoprostanes prostaglandin F(2alpha)) were significantly reduced after treatment with irbesartan. Irbesartan 224-234 C-C motif chemokine ligand 2 Homo sapiens 96-130 15980221-6 2005 RESULTS: Both triptolide and dexamethasone inhibited in a dose-dependent manner the expression of IL-8 and MCP-1 in corneal fibroblasts induced by the proinflammatory cytokines IL-1beta or tumor necrosis factor (TNF)-alpha. Dexamethasone 29-42 C-C motif chemokine ligand 2 Homo sapiens 107-112 15980221-10 2005 CONCLUSIONS: Like dexamethasone, triptolide inhibited IL-8 and MCP-1 expression in cultured human corneal fibroblasts exposed to proinflammatory cytokines, an action most likely mediated by inhibition of NF-kappaB activation. triptolide 33-43 C-C motif chemokine ligand 2 Homo sapiens 63-68 15927671-3 2005 The RNase protection assay using a multi-probe template set for human chemokines revealed that ATRA induced gene expressions of a number of CC chemokines, such as monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in NB4 cells. Tretinoin 95-99 C-C motif chemokine ligand 2 Homo sapiens 163-197 15883814-3 2005 The aim of this study was to determine the possible correlation between parenchymal MCP-1 expression and TAM level by immunohistochemical analysis of 97 invasive ductal breast carcinomas, not otherwise specified (NOS), and to investigate their relation with tumor size, histological grade, mitotic activity index (MAI) and lymph node status. tam 105-108 C-C motif chemokine ligand 2 Homo sapiens 84-89 15927671-3 2005 The RNase protection assay using a multi-probe template set for human chemokines revealed that ATRA induced gene expressions of a number of CC chemokines, such as monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein (MIP)-1alpha and MIP-1beta in NB4 cells. Tretinoin 95-99 C-C motif chemokine ligand 2 Homo sapiens 199-204 15927671-5 2005 APL cells prepared from two APL patients showed gene expression of chemokines, such as IL-8, MCP-1, MIP-1alpha, and MIP-1beta when stimulated with ATRA in vitro. Tretinoin 147-151 C-C motif chemokine ligand 2 Homo sapiens 93-98 15984600-7 2005 Furthermore, 10(-5)M montelukast significantly inhibited lipopolysaccharide-induced IL-6, TNF-alpha, and MCP-1 production in the peripheral blood mononuclear cells of controls and patients with asthma. montelukast 21-32 C-C motif chemokine ligand 2 Homo sapiens 105-110 16444871-9 2005 Exogenous ADMA also stimulated secretion of monocyte chemotactic protein-1 and interleukin-8. N,N-dimethylarginine 10-14 C-C motif chemokine ligand 2 Homo sapiens 44-74 15984600-9 2005 CONCLUSIONS: These findings suggest that high doses of montelukast modulate the production of IL-6, TNF-alpha, and MCP-1 through the inhibition of NF-kappaB activation. montelukast 55-66 C-C motif chemokine ligand 2 Homo sapiens 115-120 16045029-2 2005 METHODS: Immunohistochemical method of avidin-biotin complex was used for microvessel counts on the routinely formalin-fixed and paraffin-embedded sections of specimens of hypertrophic scars, keloids, normal skin, and surgical scar, and in situ hybridization for the expressions of IL-8, MCP-1, MIP-1alpha mRNA. avidin-biotin 39-52 C-C motif chemokine ligand 2 Homo sapiens 288-293 15755869-4 2005 Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs. Serine 21-24 C-C motif chemokine ligand 2 Homo sapiens 110-144 15755869-4 2005 Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs. Serine 21-24 C-C motif chemokine ligand 2 Homo sapiens 146-151 15893700-3 2005 Our results show that NHA treated with morphine showed significant downregulation of the gene expression of beta chemokines, MCP-1, and MIP-1 beta, while reciprocally upregulating the expression of their specific receptors, CCR2b, CCR3, and CCR5 as detected by real-time quantitative PCR. Morphine 39-47 C-C motif chemokine ligand 2 Homo sapiens 125-130 15755869-4 2005 Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs. Serine 21-24 C-C motif chemokine ligand 2 Homo sapiens 220-225 15755869-4 2005 Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs. phenylalanylleucine 25-32 C-C motif chemokine ligand 2 Homo sapiens 110-144 15755869-4 2005 Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs. phenylalanylleucine 25-32 C-C motif chemokine ligand 2 Homo sapiens 146-151 15755869-4 2005 Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs. phenylalanylleucine 25-32 C-C motif chemokine ligand 2 Homo sapiens 220-225 15755869-4 2005 Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs. Leucine 29-32 C-C motif chemokine ligand 2 Homo sapiens 110-144 15755869-4 2005 Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs. Leucine 29-32 C-C motif chemokine ligand 2 Homo sapiens 146-151 15755869-4 2005 Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs. Leucine 29-32 C-C motif chemokine ligand 2 Homo sapiens 220-225 15755869-4 2005 Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs. Arginine 37-40 C-C motif chemokine ligand 2 Homo sapiens 110-144 15755869-4 2005 Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs. Aspartic Acid 41-44 C-C motif chemokine ligand 2 Homo sapiens 110-144 15755869-4 2005 Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs. Aspartic Acid 41-44 C-C motif chemokine ligand 2 Homo sapiens 146-151 15755869-4 2005 Thrombin and SFLLRN (Ser-Phe-Leu-Leu-Arg-Asp), a PAR1 agonist peptide, increased the mRNA expression of IL-8, monocyte chemoattractant protein-1 (MCP-1), and cyclooxygenase-2 (COX-2) and the protein secretion of IL-8 nd MCP-1 in ESCs. Aspartic Acid 41-44 C-C motif chemokine ligand 2 Homo sapiens 220-225 15755869-5 2005 The addition of thrombin inhibitor d-phenylalanyl-l-prolyl-l arginine chloromethyl ketone (PPACK) together with thrombin inhibited the thrombin-induced secretion of IL-8 and MCP-1. d-phenylalanyl-l-prolyl-l arginine chloromethyl ketone 35-89 C-C motif chemokine ligand 2 Homo sapiens 174-179 15701708-6 2005 AGIX-4207 selectively inhibited tumor necrosis factor (TNF)-alpha-inducible levels of the redox-sensitive genes, vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1, with less inhibition of E-selectin, and no effect on intracellular adhesion molecule-1 expression in endothelial cells. agix 0-4 C-C motif chemokine ligand 2 Homo sapiens 151-185 15741158-8 2005 In addition to a marked reduction in neutrophil influx, 1 reversed increases in inflammatory mediators interleukin-1alpha, interleukin-1beta, tissue necrosis factor-alpha, and monocyte chemotactic protein-1 in the glycogen model and reversed increases in airway nitric oxide levels in the lipopolysaccharide model. Glycogen 214-222 C-C motif chemokine ligand 2 Homo sapiens 176-206 15701708-7 2005 In addition, AGIX-4207 inhibited cytokine-induced levels of monocyte chemoattractant protein-1, interleukin (IL)-6, and IL-8 from endothelial cells and human fibroblast-like synoviocytes as well as lipopolysaccharide-induced release of TNF-alpha, IL-1beta, and IL-6 from human peripheral blood mononuclear cells. camobucol 13-22 C-C motif chemokine ligand 2 Homo sapiens 60-94 15985720-3 2005 The aim of our study was to assess the effect of fenofibrate, a commonly used hypolipidemic drug, on the release of interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1) by monocytes from patients with combined hyperlipidemia. Fenofibrate 49-60 C-C motif chemokine ligand 2 Homo sapiens 171-205 15985720-3 2005 The aim of our study was to assess the effect of fenofibrate, a commonly used hypolipidemic drug, on the release of interleukin 1beta (IL-1beta), interleukin 6 (IL-6) and monocyte chemoattractant protein 1 (MCP-1) by monocytes from patients with combined hyperlipidemia. Fenofibrate 49-60 C-C motif chemokine ligand 2 Homo sapiens 207-212 15985720-10 2005 Thirty-day fenofibrate treatment decreased the release of IL-1beta by 43% (143.9 +/- 6.5 vs. 86.2 +/- 5.9 pg/ml), of IL-6 by 22% (8212 +/- 285 vs. 6330 +/- 234 pg/ml), and of MCP-1 by 29% (19.6 +/- 0.9 vs. 14.0 +/- 0.8 ng/ml). Fenofibrate 11-22 C-C motif chemokine ligand 2 Homo sapiens 175-180 15689417-8 2005 Furthermore, using tin protoporphyrin IX (SnPP) and anti-MCP-1 antibody to abolish iAs-induced HO-1 and MCP-1 activity, respectively, shows that HO-1 has protective effect against iAs-induced injury in VSMCs and MCP-1 is chemoattractive to human monocytes, THP-1. S-Nitroso-N-propionyl-D,L-penicillamine 42-46 C-C motif chemokine ligand 2 Homo sapiens 104-109 15850408-4 2005 Pravastatin inhibited the overproduction of monocyte chemoattractant protein 1, IL6 and IL8 and the enhanced expression of intercellular adhesion molecule 1 but had no effect on platelet-endothelial cell adhesion molecule 1 expression. Pravastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 44-78 15689417-0 2005 Oxidative stress mediates sodium arsenite-induced expression of heme oxygenase-1, monocyte chemoattractant protein-1, and interleukin-6 in vascular smooth muscle cells. sodium arsenite 26-41 C-C motif chemokine ligand 2 Homo sapiens 82-116 15689417-8 2005 Furthermore, using tin protoporphyrin IX (SnPP) and anti-MCP-1 antibody to abolish iAs-induced HO-1 and MCP-1 activity, respectively, shows that HO-1 has protective effect against iAs-induced injury in VSMCs and MCP-1 is chemoattractive to human monocytes, THP-1. S-Nitroso-N-propionyl-D,L-penicillamine 42-46 C-C motif chemokine ligand 2 Homo sapiens 104-109 16220783-0 2005 [Intervention of cetirizine on monocyte chemoattractant protein-1 in cutaneous inflammation]. Cetirizine 17-27 C-C motif chemokine ligand 2 Homo sapiens 31-65 15689417-6 2005 In iAs-treated rVSMCs, catalase, dimethylsulfoxide, and L-omega-nitro-L-arginine significantly inhibited the increase in expression of all three genes, allopurinol inhibited the increase in MCP-1 and IL-6 expression, but had no effect on HO-1 expression, while superoxide dismutase had no significant effect on HO-1 expression, but had an inhibitory effect on IL-6 expression and a stimulatory effect on MCP-1 expression. l-omega-nitro-l-arginine 56-80 C-C motif chemokine ligand 2 Homo sapiens 404-409 15689417-7 2005 Therefore, iAs may enhance the expression of HO-1, MCP-1, and IL-6 in VSMCs via different reactive oxygen molecules. 4-Iodoacetamidosalicylic acid 11-14 C-C motif chemokine ligand 2 Homo sapiens 51-56 15689417-8 2005 Furthermore, using tin protoporphyrin IX (SnPP) and anti-MCP-1 antibody to abolish iAs-induced HO-1 and MCP-1 activity, respectively, shows that HO-1 has protective effect against iAs-induced injury in VSMCs and MCP-1 is chemoattractive to human monocytes, THP-1. tin protoporphyrin IX 19-40 C-C motif chemokine ligand 2 Homo sapiens 104-109 15689417-8 2005 Furthermore, using tin protoporphyrin IX (SnPP) and anti-MCP-1 antibody to abolish iAs-induced HO-1 and MCP-1 activity, respectively, shows that HO-1 has protective effect against iAs-induced injury in VSMCs and MCP-1 is chemoattractive to human monocytes, THP-1. tin protoporphyrin IX 19-40 C-C motif chemokine ligand 2 Homo sapiens 104-109 15957833-0 2005 [Effect of triptolide on urinary monocyte chemottractant protein-1 in patients with diabetic nephropathy]. triptolide 11-21 C-C motif chemokine ligand 2 Homo sapiens 33-66 16220783-1 2005 AIM: To study the intervention of cetirizine on monocyte chemoattractant protein-1 (MCP-1) in different cutaneous inflammation models. Cetirizine 34-44 C-C motif chemokine ligand 2 Homo sapiens 48-82 16220783-1 2005 AIM: To study the intervention of cetirizine on monocyte chemoattractant protein-1 (MCP-1) in different cutaneous inflammation models. Cetirizine 34-44 C-C motif chemokine ligand 2 Homo sapiens 84-89 16220783-4 2005 RESULTS: Compared with the control group of dermal fibroblast (DF) cells and HaCaT cells, MCP-1 mRNA was significantly upregulated by histamine (10 micromol x L(-1)) and IFN-gamma (20 ng x mL(-1)). Histamine 134-143 C-C motif chemokine ligand 2 Homo sapiens 90-95 16220783-7 2005 The enhancing effects of histamine and IFN-gamma on MCP-1 protein production were significantly inhibited by cetirizine (1 and 10 micromol x L(-1)) in DF and HaCaT cells. Histamine 25-34 C-C motif chemokine ligand 2 Homo sapiens 52-57 16220783-7 2005 The enhancing effects of histamine and IFN-gamma on MCP-1 protein production were significantly inhibited by cetirizine (1 and 10 micromol x L(-1)) in DF and HaCaT cells. Cetirizine 109-119 C-C motif chemokine ligand 2 Homo sapiens 52-57 16220783-8 2005 CONCLUSION: Cetirizine may exert the anti-inflammatory effect of skin via inhibiting MCP-1 expression. Cetirizine 12-22 C-C motif chemokine ligand 2 Homo sapiens 85-90 15780578-9 2005 These results suggest that MCP-1 expression is upregulated in P. gingivalis-infected endothelial cells via reactive oxygen species, p38 MAP kinase, JNK, NF-kappaB, and AP-1. Reactive Oxygen Species 107-130 C-C motif chemokine ligand 2 Homo sapiens 27-32 15722361-9 2005 When RANKL signaling through NFATc1 was blocked with cyclosporin A, both MCP-1 and RANTES expression was down-regulated. Cyclosporine 53-66 C-C motif chemokine ligand 2 Homo sapiens 73-78 15722361-10 2005 Furthermore, addition of MCP-1 and RANTES reversed the effects of cyclosporin A and recovered the TRAP-positive multinuclear cell phenotype. Cyclosporine 66-79 C-C motif chemokine ligand 2 Homo sapiens 25-30 15784037-11 2005 Treatment of HIMEC with homocysteine, and synergistically with the combination of TNF-alpha and homocysteine, triggered HIMEC inflammation, resulting in VCAM-1 up-regulation, MCP-1 production, and p38 phosphorylation. Homocysteine 24-36 C-C motif chemokine ligand 2 Homo sapiens 175-180 15784037-11 2005 Treatment of HIMEC with homocysteine, and synergistically with the combination of TNF-alpha and homocysteine, triggered HIMEC inflammation, resulting in VCAM-1 up-regulation, MCP-1 production, and p38 phosphorylation. Homocysteine 96-108 C-C motif chemokine ligand 2 Homo sapiens 175-180 15777559-1 2005 Our previous study demonstrated that homocysteine (Hcy) mediated the expression and secretion of MCP-1 and IL-8 in human monocytes. Homocysteine 37-49 C-C motif chemokine ligand 2 Homo sapiens 97-102 15777559-1 2005 Our previous study demonstrated that homocysteine (Hcy) mediated the expression and secretion of MCP-1 and IL-8 in human monocytes. Homocysteine 51-54 C-C motif chemokine ligand 2 Homo sapiens 97-102 15777559-5 2005 After patients with HHcy underwent low-dose folic acid treatment (0.8 mg/d) for 6 months, plasma Hcy levels were decreased and the hyper-responsiveness of MCP-1 and IL-8 secreted by isolated monocytes was significantly reversed. Folic Acid 44-54 C-C motif chemokine ligand 2 Homo sapiens 155-160 15777559-5 2005 After patients with HHcy underwent low-dose folic acid treatment (0.8 mg/d) for 6 months, plasma Hcy levels were decreased and the hyper-responsiveness of MCP-1 and IL-8 secreted by isolated monocytes was significantly reversed. Homocysteine 21-24 C-C motif chemokine ligand 2 Homo sapiens 155-160 15802346-6 2005 CCL2 levels correlated negatively with the carbon monoxide diffusing capacity of the lung (D(L,CO)) and arterial oxygen tension. Carbon Monoxide 43-58 C-C motif chemokine ligand 2 Homo sapiens 0-4 15671098-6 2005 MCP-1 is stimulated by IL-1beta, TNF-alpha, IL-8, IL-4, and IL-6 + IL-6-soluble receptor and is decreased by dexamethasone, IL-10, metformin, and thiazolidinediones. Dexamethasone 109-122 C-C motif chemokine ligand 2 Homo sapiens 0-5 15802346-6 2005 CCL2 levels correlated negatively with the carbon monoxide diffusing capacity of the lung (D(L,CO)) and arterial oxygen tension. Oxygen 113-119 C-C motif chemokine ligand 2 Homo sapiens 0-4 15962714-3 2005 The poly IC-induced up-regulation of MCP-1 was blocked by 2-aminopurine, a specific inhibitor of dsRNA-dependent protein kinase, but not by nuclear factor (NF)-kappaB inhibitor SN50. 2-Aminopurine 58-71 C-C motif chemokine ligand 2 Homo sapiens 37-42 15671098-6 2005 MCP-1 is stimulated by IL-1beta, TNF-alpha, IL-8, IL-4, and IL-6 + IL-6-soluble receptor and is decreased by dexamethasone, IL-10, metformin, and thiazolidinediones. Metformin 131-140 C-C motif chemokine ligand 2 Homo sapiens 0-5 15671098-6 2005 MCP-1 is stimulated by IL-1beta, TNF-alpha, IL-8, IL-4, and IL-6 + IL-6-soluble receptor and is decreased by dexamethasone, IL-10, metformin, and thiazolidinediones. Thiazolidinediones 146-164 C-C motif chemokine ligand 2 Homo sapiens 0-5 15772519-0 2005 Effect of monthly atorvastatin and fenofibrate treatment on monocyte chemoattractant protein-1 release in patients with primary mixed dyslipidemia. Atorvastatin 18-30 C-C motif chemokine ligand 2 Homo sapiens 60-94 15772519-0 2005 Effect of monthly atorvastatin and fenofibrate treatment on monocyte chemoattractant protein-1 release in patients with primary mixed dyslipidemia. Fenofibrate 35-46 C-C motif chemokine ligand 2 Homo sapiens 60-94 15671098-8 2005 Despite this, MCP-1 may be involved in obesity-related health complications, and the decrease of MCP-1 by metformin and thiazolidinediones suggests that these antidiabetic compounds have antiinflammatory properties improving the low-grade inflammatory state observed in obesity. Metformin 106-115 C-C motif chemokine ligand 2 Homo sapiens 97-102 15772519-1 2005 The aim of this study was to compare the effect of 30-day treatment with atorvastatin and fenofibrate on monocyte release and plasma levels of monocyte chemoattractant protein-1 (MCP-1). Atorvastatin 73-85 C-C motif chemokine ligand 2 Homo sapiens 143-177 15671098-8 2005 Despite this, MCP-1 may be involved in obesity-related health complications, and the decrease of MCP-1 by metformin and thiazolidinediones suggests that these antidiabetic compounds have antiinflammatory properties improving the low-grade inflammatory state observed in obesity. Thiazolidinediones 120-138 C-C motif chemokine ligand 2 Homo sapiens 97-102 15772519-8 2005 MCP-1-lowering effect of atorvastatin and fenofibrate did not correlate with the lipid-lowering potential of these agents. Atorvastatin 25-37 C-C motif chemokine ligand 2 Homo sapiens 0-5 15772519-9 2005 Our results suggest that atorvastatin and fenofibrate produce their antiinflammatory effect partially via inhibiting monocyte release of MCP-1. Atorvastatin 25-37 C-C motif chemokine ligand 2 Homo sapiens 137-142 15698426-10 2005 RESULTS: Both EPA and DHA at 10 micromol/L and 100 micromol/L concentrations effectively decreased lipopolysaccharide (LPS)-induced nuclear factor-kappaB (NF-kappaB) activation and monocyte chemoattractant protein-1 (MCP-1) expression. Eicosapentaenoic Acid 14-17 C-C motif chemokine ligand 2 Homo sapiens 181-215 15772519-9 2005 Our results suggest that atorvastatin and fenofibrate produce their antiinflammatory effect partially via inhibiting monocyte release of MCP-1. Fenofibrate 42-53 C-C motif chemokine ligand 2 Homo sapiens 137-142 15928736-9 2005 In pts with STEMI, peak levels of MCP-1 and MIP-1alpha were significantly higher 3h than 24h from admission (MCP-1 1274.4 vs 1097.4 pg/ml, p<0.02; MIP-1alpha 39.2 vs 22.0 pg/ml, p<0.01). Tritium 81-83 C-C motif chemokine ligand 2 Homo sapiens 34-39 15677312-0 2005 Mechanical stretch induces monocyte chemoattractant activity via an NF-kappaB-dependent monocyte chemoattractant protein-1-mediated pathway in human mesangial cells: inhibition by rosiglitazone. Rosiglitazone 180-193 C-C motif chemokine ligand 2 Homo sapiens 88-122 15677312-8 2005 Combined exposure to both stretch and high glucose further increased MCP-1 production. Glucose 43-50 C-C motif chemokine ligand 2 Homo sapiens 69-74 15677312-10 2005 The addition of rosiglitazone significantly diminished stretch-induced NF-kappaB activation, MCP-1 production, and monocyte chemotaxis. Rosiglitazone 16-29 C-C motif chemokine ligand 2 Homo sapiens 93-98 15525793-0 2005 Cilostazol prevents remnant lipoprotein particle-induced monocyte adhesion to endothelial cells by suppression of adhesion molecules and monocyte chemoattractant protein-1 expression via lectin-like receptor for oxidized low-density lipoprotein receptor activation. Cilostazol 0-10 C-C motif chemokine ligand 2 Homo sapiens 137-171 15698426-10 2005 RESULTS: Both EPA and DHA at 10 micromol/L and 100 micromol/L concentrations effectively decreased lipopolysaccharide (LPS)-induced nuclear factor-kappaB (NF-kappaB) activation and monocyte chemoattractant protein-1 (MCP-1) expression. Docosahexaenoic Acids 22-25 C-C motif chemokine ligand 2 Homo sapiens 181-215 15698426-10 2005 RESULTS: Both EPA and DHA at 10 micromol/L and 100 micromol/L concentrations effectively decreased lipopolysaccharide (LPS)-induced nuclear factor-kappaB (NF-kappaB) activation and monocyte chemoattractant protein-1 (MCP-1) expression. Docosahexaenoic Acids 22-25 C-C motif chemokine ligand 2 Homo sapiens 217-222 15781755-7 2005 Simvastatin-treated monocytes showed little chemotaxis movement in response to monocyte chemoattractant protein-1 (MCP-1), a specific CCR2 ligand. Simvastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 79-113 15781755-7 2005 Simvastatin-treated monocytes showed little chemotaxis movement in response to monocyte chemoattractant protein-1 (MCP-1), a specific CCR2 ligand. Simvastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 115-120 15781755-10 2005 CONCLUSIONS: The inhibition of CCR2/MCP-1-dependent monocyte recruitment by simvastatin may prevent excessive accumulation of monocytes in the arterial wall during atherogenesis. Simvastatin 76-87 C-C motif chemokine ligand 2 Homo sapiens 36-41 15677312-11 2005 In conclusion, stretching of mesangial cells stimulates their monocyte chemoattractant activity via an NF-kappaB-mediated, MCP-1-dependent pathway, and this effect is prevented by rosiglitazone. Rosiglitazone 180-193 C-C motif chemokine ligand 2 Homo sapiens 123-128 15698426-10 2005 RESULTS: Both EPA and DHA at 10 micromol/L and 100 micromol/L concentrations effectively decreased lipopolysaccharide (LPS)-induced nuclear factor-kappaB (NF-kappaB) activation and monocyte chemoattractant protein-1 (MCP-1) expression. Eicosapentaenoic Acid 14-17 C-C motif chemokine ligand 2 Homo sapiens 217-222 15607817-9 2005 Thus, U0126, which blocked C3a-induced RANTES/CCL5 production by 50.6+/-2.3%, inhibited MCP-1/CCL2 generation by 85.2+/-0.6%. U 0126 6-11 C-C motif chemokine ligand 2 Homo sapiens 88-93 15607817-9 2005 Thus, U0126, which blocked C3a-induced RANTES/CCL5 production by 50.6+/-2.3%, inhibited MCP-1/CCL2 generation by 85.2+/-0.6%. U 0126 6-11 C-C motif chemokine ligand 2 Homo sapiens 94-98 15607817-10 2005 In contrast, LY294002 had no effect on C3a-induced RANTES/CCL5 production but blocked MCP-1/CCL2 generation by 83.7+/-1.5%. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 13-21 C-C motif chemokine ligand 2 Homo sapiens 86-91 15607817-10 2005 In contrast, LY294002 had no effect on C3a-induced RANTES/CCL5 production but blocked MCP-1/CCL2 generation by 83.7+/-1.5%. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 13-21 C-C motif chemokine ligand 2 Homo sapiens 92-96 15921025-8 2005 These results demonstrate that nifedipine could inhibit the TNF-alpha-induced upregulation of MCP-1 mRNA levels via suppression of CD40 expression in HUVEC. Nifedipine 31-41 C-C motif chemokine ligand 2 Homo sapiens 94-99 15711752-0 2005 Fluvastatin increases the expression of adhesion molecules, monocyte chemoattractant protein-1 and tissue factor in HUVEC stimulated by patient IgG fractions containing antiphospholipid antibodies. Fluvastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 60-94 15531761-4 2005 We reported here that the PPARgamma agonists 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) and troglitazone, but not PPARalpha agonist WY-14643, inhibited TNFalpha-induced production of eotaxin and monocyte chemotactic protein-1 (MCP-1) but not IL-8. Troglitazone 91-103 C-C motif chemokine ligand 2 Homo sapiens 194-224 15531761-4 2005 We reported here that the PPARgamma agonists 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) and troglitazone, but not PPARalpha agonist WY-14643, inhibited TNFalpha-induced production of eotaxin and monocyte chemotactic protein-1 (MCP-1) but not IL-8. Troglitazone 91-103 C-C motif chemokine ligand 2 Homo sapiens 226-231 15921025-0 2005 Nifedipine inhibits tumor necrosis factor-alpha-induced upregulation of monocyte chemoattractant protein-1 mRNA levels by suppressing CD40 expression in endothelial cells. Nifedipine 0-10 C-C motif chemokine ligand 2 Homo sapiens 72-106 15921025-2 2005 We have previously shown that nifedipine, one of the most popular DHPs, inhibits tumor necrosis factor-alpha (TNF-alpha)-induced reactive oxygen species generation and subsequent monocyte chemoattractant protein-1 (MCP-1) expression in human umbilical vein endothelial cells (HUVEC). Nifedipine 30-40 C-C motif chemokine ligand 2 Homo sapiens 179-213 15668340-6 2005 Dipyridamole but not aspirin attenuated nuclear translocation of NF-kappaB and blocked the synthesis of MCP-1 at the transcriptional level. Dipyridamole 0-12 C-C motif chemokine ligand 2 Homo sapiens 104-109 15668340-10 2005 Dipyridamole also blocked MCP-1 and MMP-9 generated by lipopolysaccharide-treated monocytes, indicating that at least part of its inhibitory action is unrelated to its antiplatelet properties. Dipyridamole 0-12 C-C motif chemokine ligand 2 Homo sapiens 26-31 15680279-8 2005 Furthermore, troglitazone significantly inhibited MCP-1 binding to THP-1. Troglitazone 13-25 C-C motif chemokine ligand 2 Homo sapiens 50-55 16839106-4 2005 This scheme was applied to several elementary bimolecular addition reactions: (A) BH(3) + H(2)O --> H(2)O.BH(3); (B) BF(3) + NH(3) --> FB(3).NH(3); (C) SO(3) + NH(3) --> O(3)S.NH(3); (D) C(2)H(4) + CCl(2) --> H(4)C(2).CCl(2); (E) Ni(NH(2))(2) + PH(3) --> (NH(2))(2)Ni.PH(3); (F) W(CO)(5) + CO --> W(CO)(6). Carbon Monoxide 296-298 C-C motif chemokine ligand 2 Homo sapiens 207-213 16839106-4 2005 This scheme was applied to several elementary bimolecular addition reactions: (A) BH(3) + H(2)O --> H(2)O.BH(3); (B) BF(3) + NH(3) --> FB(3).NH(3); (C) SO(3) + NH(3) --> O(3)S.NH(3); (D) C(2)H(4) + CCl(2) --> H(4)C(2).CCl(2); (E) Ni(NH(2))(2) + PH(3) --> (NH(2))(2)Ni.PH(3); (F) W(CO)(5) + CO --> W(CO)(6). Carbon Monoxide 296-298 C-C motif chemokine ligand 2 Homo sapiens 230-236 16839106-4 2005 This scheme was applied to several elementary bimolecular addition reactions: (A) BH(3) + H(2)O --> H(2)O.BH(3); (B) BF(3) + NH(3) --> FB(3).NH(3); (C) SO(3) + NH(3) --> O(3)S.NH(3); (D) C(2)H(4) + CCl(2) --> H(4)C(2).CCl(2); (E) Ni(NH(2))(2) + PH(3) --> (NH(2))(2)Ni.PH(3); (F) W(CO)(5) + CO --> W(CO)(6). Carbon Monoxide 305-310 C-C motif chemokine ligand 2 Homo sapiens 207-213 16839106-4 2005 This scheme was applied to several elementary bimolecular addition reactions: (A) BH(3) + H(2)O --> H(2)O.BH(3); (B) BF(3) + NH(3) --> FB(3).NH(3); (C) SO(3) + NH(3) --> O(3)S.NH(3); (D) C(2)H(4) + CCl(2) --> H(4)C(2).CCl(2); (E) Ni(NH(2))(2) + PH(3) --> (NH(2))(2)Ni.PH(3); (F) W(CO)(5) + CO --> W(CO)(6). Carbon Monoxide 305-310 C-C motif chemokine ligand 2 Homo sapiens 230-236 16839106-4 2005 This scheme was applied to several elementary bimolecular addition reactions: (A) BH(3) + H(2)O --> H(2)O.BH(3); (B) BF(3) + NH(3) --> FB(3).NH(3); (C) SO(3) + NH(3) --> O(3)S.NH(3); (D) C(2)H(4) + CCl(2) --> H(4)C(2).CCl(2); (E) Ni(NH(2))(2) + PH(3) --> (NH(2))(2)Ni.PH(3); (F) W(CO)(5) + CO --> W(CO)(6). Carbon Monoxide 305-307 C-C motif chemokine ligand 2 Homo sapiens 207-213 16839106-4 2005 This scheme was applied to several elementary bimolecular addition reactions: (A) BH(3) + H(2)O --> H(2)O.BH(3); (B) BF(3) + NH(3) --> FB(3).NH(3); (C) SO(3) + NH(3) --> O(3)S.NH(3); (D) C(2)H(4) + CCl(2) --> H(4)C(2).CCl(2); (E) Ni(NH(2))(2) + PH(3) --> (NH(2))(2)Ni.PH(3); (F) W(CO)(5) + CO --> W(CO)(6). Carbon Monoxide 305-307 C-C motif chemokine ligand 2 Homo sapiens 230-236 15659119-0 2005 Signal pathways underlying homocysteine-induced production of MCP-1 and IL-8 in cultured human whole blood. Homocysteine 27-39 C-C motif chemokine ligand 2 Homo sapiens 62-67 15659119-4 2005 PPARgamma activators (ciglitazone 30 micromol/L and troglitazone 10 micromol/L) depressed the Hcy-induced MCP-1 production but not IL-8 production in the cultured whole blood. ciglitazone 22-33 C-C motif chemokine ligand 2 Homo sapiens 106-111 15659119-4 2005 PPARgamma activators (ciglitazone 30 micromol/L and troglitazone 10 micromol/L) depressed the Hcy-induced MCP-1 production but not IL-8 production in the cultured whole blood. Troglitazone 52-64 C-C motif chemokine ligand 2 Homo sapiens 106-111 15659119-4 2005 PPARgamma activators (ciglitazone 30 micromol/L and troglitazone 10 micromol/L) depressed the Hcy-induced MCP-1 production but not IL-8 production in the cultured whole blood. Homocysteine 94-97 C-C motif chemokine ligand 2 Homo sapiens 106-111 15659119-5 2005 CONCLUSION: Hcy-induced MCP-1 and IL-8 production is mediated by activated signaling pathways such as PKC, CaM, MAPK, and NF-kappaB. Homocysteine 12-15 C-C motif chemokine ligand 2 Homo sapiens 24-29 15606618-6 2005 IkappaB-alpha phosphorylation inhibitor, BAY 11-7082, and p38 MAPK inhibitor, SB 203580 could decrease the release of IL-8, IP-10 and MCP-1 in the coculture. SB 203580 78-87 C-C motif chemokine ligand 2 Homo sapiens 134-139 15921025-2 2005 We have previously shown that nifedipine, one of the most popular DHPs, inhibits tumor necrosis factor-alpha (TNF-alpha)-induced reactive oxygen species generation and subsequent monocyte chemoattractant protein-1 (MCP-1) expression in human umbilical vein endothelial cells (HUVEC). Nifedipine 30-40 C-C motif chemokine ligand 2 Homo sapiens 215-220 15921025-2 2005 We have previously shown that nifedipine, one of the most popular DHPs, inhibits tumor necrosis factor-alpha (TNF-alpha)-induced reactive oxygen species generation and subsequent monocyte chemoattractant protein-1 (MCP-1) expression in human umbilical vein endothelial cells (HUVEC). dhps 66-70 C-C motif chemokine ligand 2 Homo sapiens 179-213 15921025-2 2005 We have previously shown that nifedipine, one of the most popular DHPs, inhibits tumor necrosis factor-alpha (TNF-alpha)-induced reactive oxygen species generation and subsequent monocyte chemoattractant protein-1 (MCP-1) expression in human umbilical vein endothelial cells (HUVEC). dhps 66-70 C-C motif chemokine ligand 2 Homo sapiens 215-220 15921025-5 2005 In this study, we investigated the involvement of CD40 in MCP-1 suppression by nifedipine in TNF-alpha-exposed HUVEC. Nifedipine 79-89 C-C motif chemokine ligand 2 Homo sapiens 58-63 16173056-4 2005 A macroarray hybridization analysis showed that expression of the CXCR4, MCP-1, and MRP8 genes was modified by acrylonitrile exposure. Acrylonitrile 111-124 C-C motif chemokine ligand 2 Homo sapiens 73-78 15589507-7 2005 Among studied inflammatory genes, induction of IL-1beta and MCP-1 was potentiated in animals injected with EtOH plus Tat. Ethanol 107-111 C-C motif chemokine ligand 2 Homo sapiens 60-65 16245210-0 2005 CCL2 (MCP-1) and CCL5 (RANTES) levels in the peripheral blood of multiple sclerosis patients treated with Glatiramer Acetate (Copaxone). Glatiramer Acetate 106-124 C-C motif chemokine ligand 2 Homo sapiens 0-4 16245210-0 2005 CCL2 (MCP-1) and CCL5 (RANTES) levels in the peripheral blood of multiple sclerosis patients treated with Glatiramer Acetate (Copaxone). Glatiramer Acetate 126-134 C-C motif chemokine ligand 2 Homo sapiens 0-4 16245210-3 2005 After one year of therapy with glatiramer acetate, the level of MCP-1 was almost identical with that at the starting point. Glatiramer Acetate 31-49 C-C motif chemokine ligand 2 Homo sapiens 64-69 16131811-9 2005 CONCLUSION: CRP exerted a proinflammatory effect in human mesangial cells by inducing MCP-1 gene expression via NF-kappaB activation, which was mediated, at least in part, through intracellular calcium and ROS. Calcium 194-201 C-C motif chemokine ligand 2 Homo sapiens 86-91 15893134-11 2005 Furthermore, we have very recently found that serum levels of monocyte chemoattractant protein-1, a biomarker for subclinical atherosclerosis, were significantly decreased by the treatment of azelnidipine in patients with essential hypertension. azelnidipine 192-204 C-C motif chemokine ligand 2 Homo sapiens 62-96 16131811-9 2005 CONCLUSION: CRP exerted a proinflammatory effect in human mesangial cells by inducing MCP-1 gene expression via NF-kappaB activation, which was mediated, at least in part, through intracellular calcium and ROS. Reactive Oxygen Species 206-209 C-C motif chemokine ligand 2 Homo sapiens 86-91 15534921-3 2004 In non-responders (NR), MCP-1 increased in the course of IFNalpha+RBV treatment, differences were statistically significant as compared to responders. Ribavirin 66-69 C-C motif chemokine ligand 2 Homo sapiens 24-29 15860928-4 2005 GL greatly inhibited the production of CCL2 and IL-10 in fresh PBM/MA. Glycyrrhizic Acid 0-2 C-C motif chemokine ligand 2 Homo sapiens 39-43 15860928-6 2005 CCR5 mRNA expression in fresh PBM treated with CCL2 or IL-10 was clearly inhibited by GL. Glycyrrhizic Acid 86-88 C-C motif chemokine ligand 2 Homo sapiens 47-51 15860928-7 2005 These results indicate that GL inhibits R5 HIV replication in fresh PBM/MA through the inhibiting CCR5 expression mediated by CCL2 or IL-10. Glycyrrhizic Acid 28-30 C-C motif chemokine ligand 2 Homo sapiens 126-130 15880636-7 2005 Collision-induced dissociation experiments disclosed interesting rearrangements involved in the dissociations of +CHX-CF3 ions (X = Br, Cl), which undergo fluorine migration and elimination of CF2, as already observed for +CCl2-CF3 in a previous investigation. Fluorine 155-163 C-C motif chemokine ligand 2 Homo sapiens 223-227 15849384-0 2005 Effect of kaempferol on the production and gene expression of monocyte chemoattractant protein-1 in J774.2 macrophages. kaempferol 10-20 C-C motif chemokine ligand 2 Homo sapiens 62-96 15849384-3 2005 The aim of this study was to evaluate the effect of kaempferol on the (MCP-1) gene expression and MCP-1 protein release by J774.2 macrophage cultures in vitro. kaempferol 52-62 C-C motif chemokine ligand 2 Homo sapiens 71-76 15849384-4 2005 Kaempferol given both before and after lipopolysaccharide (LPS) administration reduced secretion of MCP-1. kaempferol 0-10 C-C motif chemokine ligand 2 Homo sapiens 100-105 15849384-5 2005 Kaempferol administered before LPS stimulation significantly decreased the number of copies of MCP-1 mRNA. kaempferol 0-10 C-C motif chemokine ligand 2 Homo sapiens 95-100 15849384-6 2005 The results suggest that kaempferol inhibits MCP-1 production at the transcriptional level, and that this is an additional anti-inflammatory mechanism of action of this flavonoid. kaempferol 25-35 C-C motif chemokine ligand 2 Homo sapiens 45-50 16334978-9 2005 The tubulointerstitial MCP-1 immunoexpression was significantly correlated with monocyte/macrophage interstitial infiltrates, the immunoexpression of TGF-beta-1 in tubuli and interstitium as well as serum creatinine. Creatinine 205-215 C-C motif chemokine ligand 2 Homo sapiens 23-28 15534921-9 2004 CONCLUSION: MCP-1 concentration may be a prognostic marker of the efficacy of IFN+RBV therapy in patients with chronic hepatitis C. Ribavirin 82-85 C-C motif chemokine ligand 2 Homo sapiens 12-17 15484190-10 2004 Monocytes acquire a higher functional responsiveness to MCP-1, RANTES and SDF-1 after exposure to PGE(2), independently of the level of chemokine receptor expression. Dinoprostone 98-104 C-C motif chemokine ligand 2 Homo sapiens 56-61 15731299-9 2004 We present evidence for direct and/or indirect roles of steroid hormones on the expression of chemotactic cytokines (interleukin-8 and monocyte chemotactic protein-1) and on the survival versus apoptosis of resident endometrial cells (stromal, epithelial, and endothelial cells) and nonresident cells (leukocytes). Steroids 56-72 C-C motif chemokine ligand 2 Homo sapiens 135-165 15530425-4 2004 METHODS AND RESULTS: AngII-induced upregulation of IL-8 and MCP-1 protein and RNA in monocytes was inhibited by the AT1R-blocker losartan, but not by the AT2R-blocker PD 123.319. Losartan 129-137 C-C motif chemokine ligand 2 Homo sapiens 60-65 15530425-5 2004 Ramiprilat dose-dependently suppressed AngII-induced upregulation of IL-8 and MCP-1. ramiprilat 0-10 C-C motif chemokine ligand 2 Homo sapiens 78-83 15530425-8 2004 In addition, ramiprilat downregulated NF-kappaB activity and thereby reduced the AngII-induced release of IL-8 and MCP-1 in monocytes. ramiprilat 13-23 C-C motif chemokine ligand 2 Homo sapiens 115-120 15579413-2 2004 Exposure of AMs to silica in vitro up-regulated the messenger RNA (mRNA) levels of three genes [interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-2 (MIP-2)] without a concomitant increase in the protein levels. Silicon Dioxide 19-25 C-C motif chemokine ligand 2 Homo sapiens 118-152 15579413-2 2004 Exposure of AMs to silica in vitro up-regulated the messenger RNA (mRNA) levels of three genes [interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-2 (MIP-2)] without a concomitant increase in the protein levels. Silicon Dioxide 19-25 C-C motif chemokine ligand 2 Homo sapiens 154-159 15577845-10 2004 PGE(2) , EP2, or EP3 agonists reduced TNF-alpha-induced CCL27 secretion and mRNA levels in parallel to NF-kappaB activity and CCL2, CCL5, CXCL8, and CXCL10 mRNA levels. Prostaglandins E 0-3 C-C motif chemokine ligand 2 Homo sapiens 56-60 15569263-6 2004 Curcumin abrogated Abeta1-40-induced expression of cytokines (TNF-alpha and IL-1beta) and chemokines (MIP-1beta, MCP-1 and IL-8) in both peripheral blood monocytes and THP-1 cells. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 113-118 15624040-0 2004 Fluvastatin reduces oxidative stress, decreases serum monocyte chemotactic protein-1 level and improves endothelial function in patients with hypercholesterolemia. Fluvastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 54-84 15624040-5 2004 RESULTS: Fluvastatin significantly reduced the serum level of total cholesterol (201.8 +/- 25.2 vs 271.6 +/- 24.7 mg/dL; p < 0.001), low-density lipoprotein cholesterol (129.4 +/- 5.1 vs 190.2 +/- 19 mg/dL; p < 0.001), MCP-1 (190.3 +/- 40 vs 217.6 +/- 61 pg/mL; p = 0.001), and TBARS (3.7 +/- 1.3 vs 5.2 +/- 1.4 nmol/mL; p < 0.001). Fluvastatin 9-20 C-C motif chemokine ligand 2 Homo sapiens 225-230 15599324-4 2004 The univariate analysis demonstrated that CCL2/MCP-1 release was significantly associated with the surgical team in charge for organ harvesting, the proteins for dilution solution, the type of gradient, the type of enzyme, and the donor noradrenalin treatment. Norepinephrine 237-249 C-C motif chemokine ligand 2 Homo sapiens 42-46 15634454-9 2004 Significant down-regulation of AP-1 activation and MCP-1 expression were observed in angiotensin II-induced human mesangial cells pretreated with JNK specific inhibitor SP600125. pyrazolanthrone 169-177 C-C motif chemokine ligand 2 Homo sapiens 51-56 15599324-4 2004 The univariate analysis demonstrated that CCL2/MCP-1 release was significantly associated with the surgical team in charge for organ harvesting, the proteins for dilution solution, the type of gradient, the type of enzyme, and the donor noradrenalin treatment. Norepinephrine 237-249 C-C motif chemokine ligand 2 Homo sapiens 47-52 15528377-7 2004 Ethanol, at concentrations within the range found in human blood after acute exposure and below the levels that induce cytotoxicity (0.1-0.5%), did not induce endothelial cell activation, but significantly inhibited TNF-mediated endothelial cell activation, as measured by adhesion molecule (E-selectin, ICAM-1, VCAM-1) expression and chemokine (IL-8, MCP-1, RANTES) production and leukocyte adhesion in vitro. Ethanol 0-7 C-C motif chemokine ligand 2 Homo sapiens 352-357 15485475-9 2004 Circulating MCP-1 and IL-8 levels rose after the methionine load (P < 0.001), but not after placebo or methionine plus vitamins. Methionine 49-59 C-C motif chemokine ligand 2 Homo sapiens 12-17 15488877-4 2004 Simvastatin alone or combined with ramipril significantly changed lipoproteins, and improved the percent flow-mediated dilator response to hyperemia relative to baseline measurements by 33 +/- 6% and by 50 +/- 14%, respectively (both P <0.001) and reduced plasma levels of nitrate relative to baseline measurements (P=0.413 and 0.037, respectively), the plasma MDA levels relative to baseline measurements by 8 +/- 8% and by 18 +/- 9% (P=0.039 and P <0.001, respectively) and MCP-1 relative to baseline measurements by 7 +/- 4% and by 13 +/- 3%, respectively (P=0.019 and P <0.001, respectively), and CRP from 0.22 to 0.14 mg/dl and from 0.22 to 0.15 mg/dl, respectively (P=0.124 and 0.002, respectively), and PAI-1 antigen relative to baseline measurements (P=0.690 and 0.018, respectively). Simvastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 482-487 15488877-4 2004 Simvastatin alone or combined with ramipril significantly changed lipoproteins, and improved the percent flow-mediated dilator response to hyperemia relative to baseline measurements by 33 +/- 6% and by 50 +/- 14%, respectively (both P <0.001) and reduced plasma levels of nitrate relative to baseline measurements (P=0.413 and 0.037, respectively), the plasma MDA levels relative to baseline measurements by 8 +/- 8% and by 18 +/- 9% (P=0.039 and P <0.001, respectively) and MCP-1 relative to baseline measurements by 7 +/- 4% and by 13 +/- 3%, respectively (P=0.019 and P <0.001, respectively), and CRP from 0.22 to 0.14 mg/dl and from 0.22 to 0.15 mg/dl, respectively (P=0.124 and 0.002, respectively), and PAI-1 antigen relative to baseline measurements (P=0.690 and 0.018, respectively). Ramipril 35-43 C-C motif chemokine ligand 2 Homo sapiens 482-487 15488877-5 2004 However, simvastatin combined with ramipril changed to greater but statistically insignificant extent the percent flow-mediated dilator response to hyperemia and plasma levels of nitrate, MDA, MCP-1, and PAI-1 antigen than simvastatin alone. Simvastatin 9-20 C-C motif chemokine ligand 2 Homo sapiens 193-198 15488877-5 2004 However, simvastatin combined with ramipril changed to greater but statistically insignificant extent the percent flow-mediated dilator response to hyperemia and plasma levels of nitrate, MDA, MCP-1, and PAI-1 antigen than simvastatin alone. Ramipril 35-43 C-C motif chemokine ligand 2 Homo sapiens 193-198 15525462-0 2004 Homocysteine induces production of monocyte chemoattractant protein-1 and interleukin-8 in cultured human whole blood. Homocysteine 0-12 C-C motif chemokine ligand 2 Homo sapiens 35-69 15525462-1 2004 AIM: To investigate whether increased plasma L-homocysteine (Hcy) level could promote monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in cultured whole blood. Homocysteine 45-59 C-C motif chemokine ligand 2 Homo sapiens 86-120 15525462-1 2004 AIM: To investigate whether increased plasma L-homocysteine (Hcy) level could promote monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in cultured whole blood. Homocysteine 45-59 C-C motif chemokine ligand 2 Homo sapiens 122-127 15525462-1 2004 AIM: To investigate whether increased plasma L-homocysteine (Hcy) level could promote monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in cultured whole blood. Homocysteine 61-64 C-C motif chemokine ligand 2 Homo sapiens 86-120 15525462-1 2004 AIM: To investigate whether increased plasma L-homocysteine (Hcy) level could promote monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in cultured whole blood. Homocysteine 61-64 C-C motif chemokine ligand 2 Homo sapiens 122-127 15525462-8 2004 radicals, play extremely important role in the Hcy-induced MCP-1 and IL-8 production. Homocysteine 47-50 C-C motif chemokine ligand 2 Homo sapiens 59-64 15525462-9 2004 CONCLUSION: Increased Hcy level in plasma (hyperhomocysteinemia) induced MCP-1 and IL-8 secretion in cultured human whole blood, especially in monocytes via oxidative stress mechanism. Homocysteine 22-25 C-C motif chemokine ligand 2 Homo sapiens 73-78 15298980-9 2004 By contrast, MCP-1 is able to induce PGE2 and PGF2alpha in a concentration-dependent manner but it does not appear to contribute to the increase in PG accumulation following IL-1beta stimulation. Dinoprostone 37-41 C-C motif chemokine ligand 2 Homo sapiens 13-18 15298980-9 2004 By contrast, MCP-1 is able to induce PGE2 and PGF2alpha in a concentration-dependent manner but it does not appear to contribute to the increase in PG accumulation following IL-1beta stimulation. Dinoprost 46-55 C-C motif chemokine ligand 2 Homo sapiens 13-18 15298980-2 2004 The relationship between PG and monocyte chemoattractant protein-1 (MCP-1) has not been elucidated in human endometrium. Prostaglandins 25-27 C-C motif chemokine ligand 2 Homo sapiens 32-66 15271789-0 2004 Leukotriene B4 strongly increases monocyte chemoattractant protein-1 in human monocytes. Leukotriene B4 0-14 C-C motif chemokine ligand 2 Homo sapiens 34-68 15298980-2 2004 The relationship between PG and monocyte chemoattractant protein-1 (MCP-1) has not been elucidated in human endometrium. Prostaglandins 25-27 C-C motif chemokine ligand 2 Homo sapiens 68-73 15361371-3 2004 OBJECTIVE: To examine the effect of PGE(2) on monocyte chemoattractant protein-1 (MCP-1) expression in cultured synovial fibroblasts (SF) stimulated with interleukin (IL)1beta. Prostaglandins E 36-39 C-C motif chemokine ligand 2 Homo sapiens 46-80 15361371-3 2004 OBJECTIVE: To examine the effect of PGE(2) on monocyte chemoattractant protein-1 (MCP-1) expression in cultured synovial fibroblasts (SF) stimulated with interleukin (IL)1beta. Prostaglandins E 36-39 C-C motif chemokine ligand 2 Homo sapiens 82-87 15361371-4 2004 METHODS: MCP-1 expression was assessed in SF stimulated with IL1beta in the presence of PGE(2) or different NSAIDs by RT-PCR or northern blot and immunocytochemistry. Prostaglandins E 88-91 C-C motif chemokine ligand 2 Homo sapiens 9-14 15361371-7 2004 RESULTS: PGE(2) significantly inhibited IL1beta induced MCP-1 expression in SF in a dose dependent manner. Prostaglandins E 9-12 C-C motif chemokine ligand 2 Homo sapiens 56-61 15361371-9 2004 11-Deoxy-PGE(1), an EP(2)/EP(4) agonist, reproduced PGE(2) action on MCP-1 expression. 11-deoxy-pge 0-12 C-C motif chemokine ligand 2 Homo sapiens 69-74 15361371-9 2004 11-Deoxy-PGE(1), an EP(2)/EP(4) agonist, reproduced PGE(2) action on MCP-1 expression. Prostaglandins E 9-12 C-C motif chemokine ligand 2 Homo sapiens 69-74 15298980-9 2004 By contrast, MCP-1 is able to induce PGE2 and PGF2alpha in a concentration-dependent manner but it does not appear to contribute to the increase in PG accumulation following IL-1beta stimulation. Prostaglandins 37-39 C-C motif chemokine ligand 2 Homo sapiens 13-18 15308550-9 2004 Exogenous ADMA also stimulated secretion of MCP-1 and interleukin-8. N,N-dimethylarginine 10-14 C-C motif chemokine ligand 2 Homo sapiens 44-49 15361371-12 2004 Inhibition of endogenous PGE(2) synthesis by NSAIDs further enhanced MCP-1 mRNA expression in IL1beta stimulated SF, an effect prevented by addition of exogenous PGE(2). Prostaglandins E 25-28 C-C motif chemokine ligand 2 Homo sapiens 69-74 15361371-12 2004 Inhibition of endogenous PGE(2) synthesis by NSAIDs further enhanced MCP-1 mRNA expression in IL1beta stimulated SF, an effect prevented by addition of exogenous PGE(2). Prostaglandins E 162-165 C-C motif chemokine ligand 2 Homo sapiens 69-74 15349727-5 2004 MCP-1 decreases insulin-stimulated glucose uptake into adipocytes. Glucose 35-42 C-C motif chemokine ligand 2 Homo sapiens 0-5 15752119-0 2004 Phosphatidylcholine-specific phospholipase C but not gamma interferon regulate gene expression and secretion of CC Chemokine Ligand-2 (CCL-2) by human astrocytes during infection by Toxoplasma gondii. Phosphatidylcholines 0-19 C-C motif chemokine ligand 2 Homo sapiens 112-133 15752119-0 2004 Phosphatidylcholine-specific phospholipase C but not gamma interferon regulate gene expression and secretion of CC Chemokine Ligand-2 (CCL-2) by human astrocytes during infection by Toxoplasma gondii. Phosphatidylcholines 0-19 C-C motif chemokine ligand 2 Homo sapiens 135-140 15191916-6 2004 Accordingly, Bay-11 7082, an inhibitor of NF-kappaB activation, inhibited IL-1beta-induced IL-13 and MCP-1 expression. 3-(4-methylphenylsulfonyl)-2-propenenitrile 13-24 C-C motif chemokine ligand 2 Homo sapiens 101-106 15447840-3 2004 RESULTS: The mRNA and protein expression levels of ABCA1, ICAM-1 and MCP-1 all increased after treatments with Ox-LDL and 8-Br-cAMP. 8-Bromo Cyclic Adenosine Monophosphate 122-131 C-C motif chemokine ligand 2 Homo sapiens 69-74 15447840-5 2004 The expression peaks of ABCA1, ICAM-1 and MCP-1 all took place after 6-hour incubation with 8-Br-cAMP. 8-Bromo Cyclic Adenosine Monophosphate 92-101 C-C motif chemokine ligand 2 Homo sapiens 42-47 15447840-7 2004 cAMP not only enhances the expression of ABCA1 but also those of ICAM-1 and MCP-1. Cyclic AMP 0-4 C-C motif chemokine ligand 2 Homo sapiens 76-81 15475827-0 2004 Negative association between circulating total homocysteine and proinflammatory chemokines MCP-1 and RANTES in prepubertal lean, but not in obese, children. Homocysteine 47-59 C-C motif chemokine ligand 2 Homo sapiens 91-96 15475827-4 2004 In PLC, but not in POC, tHcy levels were negatively associated with both circulating MCP-1 (B = -1.68, P = 0.007) and RANTES (B = -1.16, P = 0.01) after adjusting for age, sex, BMI, as well as log10total insulin, vitB12, folate, total cholesterol, HDL cholesterol, log10triglycerides, and log10glucose levels. thcy 24-28 C-C motif chemokine ligand 2 Homo sapiens 85-90 15467918-9 2004 Parthenolide, an IkappaB kinase inhibitor, prevented up-regulation of MCP-1 by fibrinogen, linking this response to NF-kappaB activation. parthenolide 0-12 C-C motif chemokine ligand 2 Homo sapiens 70-75 15364009-4 2004 Benidipine also suppressed induction of monocyte chemoattractant protein (MCP)-1 and interleukin-8. benidipine 0-10 C-C motif chemokine ligand 2 Homo sapiens 40-80 15113752-12 2004 Exposure to 30 mM D-glucose reduced monocyte chemoattractant protein 1 levels to 78.6 +/- 7.1% (P < 0.05) of control, with the reduction more marked in the presence of either pioglitazone (P < 0.01) or L-805645 (P < 0.01). Glucose 18-27 C-C motif chemokine ligand 2 Homo sapiens 36-70 15306587-12 2004 The increase in CCR2(+) LPLs in SBCD was confirmed by both immunohistochemistry (p = 0.0002) and enhanced chemotactic responses to CCL2. sbcd 32-36 C-C motif chemokine ligand 2 Homo sapiens 131-135 15475827-5 2004 In conclusion, in POC there is a lack, in contrast to PLC, of a possibly autoregulatory, negative association of elevated tHcy levels to increased MCP-1 and RANTES levels. thcy 122-126 C-C motif chemokine ligand 2 Homo sapiens 147-152 15312171-5 2004 15d-PGJ2 was a potent inhibitor of proinflammatory cytokine (IL-1beta, TNF-alpha, IL-12 p40) and CC chemokine (MIP-1beta, MCP-1) production in primary microglia, but had no effect upon the expression of select CXC chemokines (MIP-2, KC). 15-deoxy-delta(12,14)-prostaglandin J2 0-8 C-C motif chemokine ligand 2 Homo sapiens 122-127 15212811-7 2004 Furthermore, Macroarray analysis showed that styrene changed cord blood gene expression, inducing up-regulation of monocyte chemotactic protein 1 (MCP-1), and down-regulation of CC chemokine receptor type 1 (CCR-1) and SLP-76 tyrosine-phosphoprotein. Styrene 45-52 C-C motif chemokine ligand 2 Homo sapiens 115-145 15212811-7 2004 Furthermore, Macroarray analysis showed that styrene changed cord blood gene expression, inducing up-regulation of monocyte chemotactic protein 1 (MCP-1), and down-regulation of CC chemokine receptor type 1 (CCR-1) and SLP-76 tyrosine-phosphoprotein. Styrene 45-52 C-C motif chemokine ligand 2 Homo sapiens 147-152 15276851-3 2004 Maximum MCP-1 expression and MIP-1 expression were observed at 17 and 21 days post-inoculation (dpi), respectively. 3-aminodiphenyleneiodium 96-99 C-C motif chemokine ligand 2 Homo sapiens 8-13 15234191-3 2004 In the present study, we investigated the effect of pitavastatin, a novel HMG CoA reductase inhibitor, on the transition from monocyte rolling on vascular endothelium to stable adhesion induced by MCP-1 under flow (shear stress = 1.0 dyne/cm(2)). pitavastatin 52-64 C-C motif chemokine ligand 2 Homo sapiens 197-202 15265658-10 2004 Poly I:C treatment of RPE resulted in an increase in the production of IL-6, IL-8, MCP-1, and sICAM-1. Poly I-C 0-8 C-C motif chemokine ligand 2 Homo sapiens 83-88 15234191-7 2004 To elucidate the mechanism by which pitavastatin modulates MCP-1-induced THP-1 adhesive interactions, the possible involvement of extracellular signal-regulated kinase 1/2 (ERK1/2) was examined. pitavastatin 36-48 C-C motif chemokine ligand 2 Homo sapiens 59-64 15234191-8 2004 Western blotting analysis using an anti-ERK1/2 Ab and an antibody against phosphorylated-ERK1/2 (p-ERK) revealed that pitavastatin treatment significantly inhibited the MCP-1-induced phosphorylation of ERK1/2. pitavastatin 118-130 C-C motif chemokine ligand 2 Homo sapiens 169-174 15234191-11 2004 These findings indicate a role for pitavastatin in modulating the MCP-1-induced phenotypic changes of monocyte-endothelial interactions, which may account for the anti-inflammatory effects of statins. pitavastatin 35-47 C-C motif chemokine ligand 2 Homo sapiens 66-71 15016614-6 2004 SB203580 and SP600125 dose-dependently inhibited CCL2 secretion and gene expression induced by IL-1 or TNF. SB 203580 0-8 C-C motif chemokine ligand 2 Homo sapiens 49-53 15016614-6 2004 SB203580 and SP600125 dose-dependently inhibited CCL2 secretion and gene expression induced by IL-1 or TNF. pyrazolanthrone 13-21 C-C motif chemokine ligand 2 Homo sapiens 49-53 15179446-7 2004 In terms of the efficacy on vascular systems, it was revealed that ramatroban can suppress the expression of monocyte chemoattractant protein-1 (MCP-1) and adhesion molecules in endothelial cells and prevent exacerbation of inflammation by blocking these responses. ramatroban 67-77 C-C motif chemokine ligand 2 Homo sapiens 109-143 15223398-5 2004 RESULTS: Polyvinylchloride induced a substantial increase in IL-8 and MCP-1, which was abolished by cycloheximide, indicating that they were synthesized during incubation. Polyvinyl Chloride 9-26 C-C motif chemokine ligand 2 Homo sapiens 70-75 15223398-8 2004 Heparin-coated polyvinylchloride efficiently prevented synthesis of both IL-8 and MCP-1. Heparin 0-7 C-C motif chemokine ligand 2 Homo sapiens 82-87 15223398-8 2004 Heparin-coated polyvinylchloride efficiently prevented synthesis of both IL-8 and MCP-1. Polyvinyl Chloride 15-32 C-C motif chemokine ligand 2 Homo sapiens 82-87 15223398-9 2004 Addition of recombinant human complement factor 5a to blood incubated in heparin-coated polyvinylchloride restored IL-8 and MCP-1 production completely and partly, respectively. Heparin 73-80 C-C motif chemokine ligand 2 Homo sapiens 124-129 15223398-9 2004 Addition of recombinant human complement factor 5a to blood incubated in heparin-coated polyvinylchloride restored IL-8 and MCP-1 production completely and partly, respectively. Polyvinyl Chloride 88-105 C-C motif chemokine ligand 2 Homo sapiens 124-129 15223398-13 2004 CONCLUSIONS: Polyvinylchloride induced a marked increase in IL-8 and MCP-1, in contrast to a marginal increase in tumor necrosis factor alpha, IL-1 beta, IL-6, and IL-10. Polyvinyl Chloride 13-30 C-C motif chemokine ligand 2 Homo sapiens 69-74 15223398-14 2004 The increase in IL-8 and MCP-1 was prevented by heparin-coated polyvinylchloride. Heparin 48-55 C-C motif chemokine ligand 2 Homo sapiens 25-30 15223398-14 2004 The increase in IL-8 and MCP-1 was prevented by heparin-coated polyvinylchloride. coated polyvinylchloride 56-80 C-C motif chemokine ligand 2 Homo sapiens 25-30 15179446-7 2004 In terms of the efficacy on vascular systems, it was revealed that ramatroban can suppress the expression of monocyte chemoattractant protein-1 (MCP-1) and adhesion molecules in endothelial cells and prevent exacerbation of inflammation by blocking these responses. ramatroban 67-77 C-C motif chemokine ligand 2 Homo sapiens 145-150 15194436-5 2004 In contrast, immunohistological analysis of kainic acid lesions on days 21-45 revealed significant expression of MCP-1 and MIP-2 associated with reactive astrocytes and macrophages, respectively, with no apoptotic populations being observed. Kainic Acid 44-55 C-C motif chemokine ligand 2 Homo sapiens 113-118 15075360-2 2004 Dex acts by inhibiting the expression of inflammatory mediators, such as tumor necrosis factor alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1). Dexamethasone 0-3 C-C motif chemokine ligand 2 Homo sapiens 117-151 15194436-1 2004 Intrahippocamal injections of kainic acid (KA) significantly increase the expression of monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-2 (MIP-2) in the ipsilateral hippocampus at 2-4 h and 21-45 days post-administration, suggesting the possible involvement of these chemokines in both neurodegenerative and regenerative processes. Kainic Acid 30-41 C-C motif chemokine ligand 2 Homo sapiens 88-122 15194436-1 2004 Intrahippocamal injections of kainic acid (KA) significantly increase the expression of monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-2 (MIP-2) in the ipsilateral hippocampus at 2-4 h and 21-45 days post-administration, suggesting the possible involvement of these chemokines in both neurodegenerative and regenerative processes. Kainic Acid 30-41 C-C motif chemokine ligand 2 Homo sapiens 124-129 15196211-4 2004 In response to zymosan and flagellin, pathogen-associated molecular patterns (PAMP) that are recognized by TLR2 and TLR5 respectively, ECC-1 cells secreted significantly more IL-8, MCP-1 and IL-6 than in response to other TLR agonists. Zymosan 15-22 C-C motif chemokine ligand 2 Homo sapiens 181-186 15075360-2 2004 Dex acts by inhibiting the expression of inflammatory mediators, such as tumor necrosis factor alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1). Dexamethasone 0-3 C-C motif chemokine ligand 2 Homo sapiens 153-158 15075360-7 2004 Dex decreased the stability of MCP-1 mRNA and did not affect TNF-alpha mRNA stability. Dexamethasone 0-3 C-C motif chemokine ligand 2 Homo sapiens 31-36 15189499-2 2004 As monocytic migration is a key event of atherogenesis, we investigated whether histamine induces monocytic expression of monocyte chemoattractant protein (MCP)-1 and its receptors CCR2-A and -B, and also endothelial expression of ICAM-1 and VCAM-1. Histamine 80-89 C-C motif chemokine ligand 2 Homo sapiens 122-162 15189499-4 2004 Histamine stimulated monocytes, but not macrophages, to express MCP-1 and CCR2-A and -B. Histamine 0-9 C-C motif chemokine ligand 2 Homo sapiens 64-69 15189499-8 2004 These results indicate that histamine and IL-4, which are both synthesized in the arterial intima, chronically participates in the pathogenesis of atherosclerosis via the enhanced expression of monocytic MCP-1, CCR2 and endothelial adhesion molecules. Histamine 28-37 C-C motif chemokine ligand 2 Homo sapiens 204-209 15189499-5 2004 The expression of MCP-1 was inhibited by histamine H2 blocker. Histamine 41-50 C-C motif chemokine ligand 2 Homo sapiens 18-23 15191525-2 2004 Recently, a nucleotide substitution from adenosine to guanosine (A-->G) at position -2518 of the MCP-1 promoter was shown to be associated with increased MCP-1 expression. Adenosine 41-50 C-C motif chemokine ligand 2 Homo sapiens 100-105 15191525-2 2004 Recently, a nucleotide substitution from adenosine to guanosine (A-->G) at position -2518 of the MCP-1 promoter was shown to be associated with increased MCP-1 expression. Adenosine 41-50 C-C motif chemokine ligand 2 Homo sapiens 157-162 15191525-2 2004 Recently, a nucleotide substitution from adenosine to guanosine (A-->G) at position -2518 of the MCP-1 promoter was shown to be associated with increased MCP-1 expression. Guanosine 54-63 C-C motif chemokine ligand 2 Homo sapiens 100-105 15191525-2 2004 Recently, a nucleotide substitution from adenosine to guanosine (A-->G) at position -2518 of the MCP-1 promoter was shown to be associated with increased MCP-1 expression. Guanosine 54-63 C-C motif chemokine ligand 2 Homo sapiens 157-162 15072991-5 2004 Ascorbate administration selectively diminished apheresis-enhanced H2O2 and inflammatory mediators such as tumor necrosis factor alpha (TNF-alpha) and monocyte chemoattractant protein-1. Ascorbic Acid 0-9 C-C motif chemokine ligand 2 Homo sapiens 151-185 15207092-0 2004 [Expression of monocyte chemoattractant protein-1 in glomerular endothelial cells stimulated by high concentration of glucose]. Glucose 118-125 C-C motif chemokine ligand 2 Homo sapiens 15-49 15207092-1 2004 AIM: To study the expression of monocyte chemoattractant protein-1 (MCP-1) in cultured human glomerular endothelial cells (HUGECs) stimulated by high concentration of glucose. Glucose 167-174 C-C motif chemokine ligand 2 Homo sapiens 32-66 15207092-1 2004 AIM: To study the expression of monocyte chemoattractant protein-1 (MCP-1) in cultured human glomerular endothelial cells (HUGECs) stimulated by high concentration of glucose. Glucose 167-174 C-C motif chemokine ligand 2 Homo sapiens 68-73 15207092-2 2004 METHODS: The effect of high concentration of glucose on the expression of MCP-1mRNA by HUGECs was detected by in situ hybridization and cell ELISA. Glucose 45-52 C-C motif chemokine ligand 2 Homo sapiens 74-79 15207092-5 2004 RESULTS: The MCP-1 mRNA was only weakly expressed in HUGECs cultured under the condition of low concentration of glucose. Glucose 113-120 C-C motif chemokine ligand 2 Homo sapiens 13-18 15207092-6 2004 Following a stimulation of high concentration of glucose (25 mmol/L), MCP-1 mRNA expression was upregulated from the 8th hour and reached the maximum at the 16th hour. Glucose 49-56 C-C motif chemokine ligand 2 Homo sapiens 70-75 15207092-7 2004 Conditioned medium of cultured HUGECs stimulated with high concentration of glucose had marked chemotaxis for monocytes, which was inhibited by anti-MCP-1 antibody. Glucose 76-83 C-C motif chemokine ligand 2 Homo sapiens 149-154 15207092-8 2004 CONCLUSION: HUGEC stimulated by high glucose may highly express MCP-1, and produce chemotatic factors for monocytes. Glucose 37-44 C-C motif chemokine ligand 2 Homo sapiens 64-69 15187150-8 2004 Finally, 15d-PGJ(2)-induced decreases in glucocorticoid binding to GR resulted in parallel decreases in the ability of GR to activate the transcription of a glucocorticoid-inducible reporter gene and to reduce the expression of monocyte chemoattractant protein-1. 15d-pgj 9-16 C-C motif chemokine ligand 2 Homo sapiens 228-262 15165934-3 2004 However, only irbesartan and candesartan therapies significantly lowered plasma levels of plasminogen activator inhibitor type-1 antigen (p <0.001 by ANOVA) with no differences between the 2, and only candesartan therapy significantly lowered plasma levels of monocyte chemoattractant protein-1 (p = 0.004 by ANOVA). candesartan 29-40 C-C motif chemokine ligand 2 Homo sapiens 263-297 15136050-0 2004 Aspirin inhibits monocyte chemoattractant protein-1 and interleukin-8 expression in TNF-alpha stimulated human umbilical vein endothelial cells. Aspirin 0-7 C-C motif chemokine ligand 2 Homo sapiens 17-51 15136050-6 2004 In this study, we found that aspirin inhibited TNF-alpha (10 ng/ml)-induced MCP-1 and IL-8 expression at the RNA and protein levels in human umbilical vein endothelial cells (HUVECs), monocyte adhesion and transmigration, and that its inhibitory effects were not due to decreased HUVEC viability as assessed by MTT test. Aspirin 29-36 C-C motif chemokine ligand 2 Homo sapiens 76-81 15149885-3 2004 The effects of PAF and oxidised LDL on the production of monocyte chemoattractant protein-1 and interleukin-8 were also examined. Platelet Activating Factor 15-18 C-C motif chemokine ligand 2 Homo sapiens 57-91 15136050-7 2004 Aspirin at the dose as low as 10 microg/ml significantly inhibited the release of TNF-stimulated MCP-1 by 29.1% (P = 0.008) and IL-8 by 26.9% (P = 0.0146) as compared to TNF-stimulated release. Aspirin 0-7 C-C motif chemokine ligand 2 Homo sapiens 97-102 15136050-11 2004 These results in our study suggest that aspirin inhibits TNF-alpha stimulated MCP-1 and IL-8 release in HUVECs, for its additional therapeutic effects of aspirin in causing atherosclerosis. Aspirin 40-47 C-C motif chemokine ligand 2 Homo sapiens 78-83 15161854-6 2004 Ly294002, a specific inhibitor of PI3K, resulted in time- and dose-dependent blockade of MCP-1 mRNA expression and protein production. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 C-C motif chemokine ligand 2 Homo sapiens 89-94 15235923-10 2004 Renal epithelial cells exposed to brushite crystals produce MCP-1. calcium phosphate, dibasic, dihydrate 34-42 C-C motif chemokine ligand 2 Homo sapiens 60-65 15235923-13 2004 Renal epithelial cells exposed to uric acid crystals synthesize MCP-1 as well as PGE2. Uric Acid 34-43 C-C motif chemokine ligand 2 Homo sapiens 64-69 15259906-3 2004 We hypothesized that CSF MCP-1 levels would correlate inversely to neuronal metabolites [including N-acetyl compounds, glutamate+glutamine, as assessed by principal component analyses (PCA)] and positively to glial metabolites (including myo-inositol and choline compounds). n-acetyl compounds 99-117 C-C motif chemokine ligand 2 Homo sapiens 25-30 15259906-3 2004 We hypothesized that CSF MCP-1 levels would correlate inversely to neuronal metabolites [including N-acetyl compounds, glutamate+glutamine, as assessed by principal component analyses (PCA)] and positively to glial metabolites (including myo-inositol and choline compounds). Glutamic Acid 119-128 C-C motif chemokine ligand 2 Homo sapiens 25-30 15259906-3 2004 We hypothesized that CSF MCP-1 levels would correlate inversely to neuronal metabolites [including N-acetyl compounds, glutamate+glutamine, as assessed by principal component analyses (PCA)] and positively to glial metabolites (including myo-inositol and choline compounds). Glutamine 129-138 C-C motif chemokine ligand 2 Homo sapiens 25-30 15259906-3 2004 We hypothesized that CSF MCP-1 levels would correlate inversely to neuronal metabolites [including N-acetyl compounds, glutamate+glutamine, as assessed by principal component analyses (PCA)] and positively to glial metabolites (including myo-inositol and choline compounds). Inositol 238-250 C-C motif chemokine ligand 2 Homo sapiens 25-30 15259906-3 2004 We hypothesized that CSF MCP-1 levels would correlate inversely to neuronal metabolites [including N-acetyl compounds, glutamate+glutamine, as assessed by principal component analyses (PCA)] and positively to glial metabolites (including myo-inositol and choline compounds). Choline 255-262 C-C motif chemokine ligand 2 Homo sapiens 25-30 15020650-7 2004 The induction of tissue factor activity by MCP-1 is blocked by PD98059, an inhibitor of p42/44 activation, but not by SB203580, a selective p38 inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 63-70 C-C motif chemokine ligand 2 Homo sapiens 43-48 15181049-10 2004 Rosiglitazone treatment resulted in a reduction in plasma MCP-1 and CRP in both groups (P < 0.05). Rosiglitazone 0-13 C-C motif chemokine ligand 2 Homo sapiens 58-63 15200281-0 2004 Correlation of MCP1 with toxicity in acetaminophen overdose. Acetaminophen 37-50 C-C motif chemokine ligand 2 Homo sapiens 15-19 14747610-5 2004 All cAMP-elevating drugs tested promoted the phosphorylation of cAMP response element-binding protein (CREB), activated a cAMP response element (CRE)-driven luciferase reporter gene, and suppressed both granulocyte/macrophage colony-stimulating factor (GM-CSF) generation and [(3)H]arachidonic acid (AA) release in response to interleukin-1beta and monocyte chemotactic protein (MCP)-1, respectively. Cyclic AMP 4-8 C-C motif chemokine ligand 2 Homo sapiens 349-385 14977559-7 2004 Renal epithelial cells on exposure to oxalate and CaOx crystals produce some of the inflammatory molecules such as monocyte chemoattractant protein-1 (MCP-1) with no apparent role in crystal formation. Oxalates 38-45 C-C motif chemokine ligand 2 Homo sapiens 115-149 14977559-7 2004 Renal epithelial cells on exposure to oxalate and CaOx crystals produce some of the inflammatory molecules such as monocyte chemoattractant protein-1 (MCP-1) with no apparent role in crystal formation. Oxalates 38-45 C-C motif chemokine ligand 2 Homo sapiens 151-156 15020650-5 2004 The induction of tissue factor by MCP-1 is blocked by pertussis toxin and 1,2-bis(O-aminophenyl-ethane-ethan)-N,N,N",N"-tetraacetic acid-acetoxymethyl ester, suggesting that signal transduction through the alternative receptor is G(alphai)-coupled and dependent on mobilization of intracellular Ca(2+). 1,2-bis(o-aminophenyl-ethane-ethan)-n,n,n",n"-tetraacetic acid-acetoxymethyl ester 74-156 C-C motif chemokine ligand 2 Homo sapiens 34-39 15148458-6 2004 However, when MC were exposed in in vitro conditions for 24 h to the studied dialysates, we observed that HA containing fluids inhibited the synthesis of MCP-1, s-ICAM, VEGF and fibronectin in these cells. Methylcholanthrene 14-16 C-C motif chemokine ligand 2 Homo sapiens 154-159 15290911-7 2004 Treating monocytes with atorvastatin resulted in the suppression of MCP-1 (42%; p < 0.05) and TNF-alpha (45%; p < 0.05) secretion. Atorvastatin 24-36 C-C motif chemokine ligand 2 Homo sapiens 68-73 14747610-9 2004 Paradoxically, H-89 antagonized MCP-1-induced [(3)H]AA release and enhanced the inhibitory effect of submaximal concentrations of rolipram and 8-bromo-cAMP. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide 15-19 C-C motif chemokine ligand 2 Homo sapiens 32-37 14617690-7 2004 Furthermore, AGI-1067 inhibited the inducible expression of the redox-sensitive genes, vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1, in endothelial cells as well as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, and IL-6 production in peripheral blood mononuclear cells, whereas probucol had no effect. succinobucol 13-21 C-C motif chemokine ligand 2 Homo sapiens 134-168 15063799-6 2004 In contrast, the glucocorticoid dexamethasone potently downregulated MCP-1 with significant suppression detectable at concentrations as low as 3 nM and as early as 2h after effector addition. Dexamethasone 32-45 C-C motif chemokine ligand 2 Homo sapiens 69-74 15033519-4 2004 Adherent cells expressing the MCP-1 receptor CCR2B are treated with MCP-1 in 96-well plates in the presence or absence of inhibitors, fixed and permeabilized with methanol, and then probed with a monoclonal antibody that selectively recognizes the doubly phosphorylated form of p44/42 MAPK. Methanol 163-171 C-C motif chemokine ligand 2 Homo sapiens 30-35 15025932-5 2004 These oxidized phospholipids were shown to induce several proinflammatory genes, such as monocyte chemoattractant protein 1 or interleukin-8, and it is hypothesized that lipid oxidation products also play a role in other chronic inflammatory disorders. Phospholipids 15-28 C-C motif chemokine ligand 2 Homo sapiens 89-123 14699155-6 2004 Inhibition of Syk with piceatannol or PI3K with wortmannin inhibited LPS-induced JNK activation and decreased MCP-1 expression after exposure to LPS, suggesting that both Syk and PI3K reside in a signaling pathway leading to LPS-induced JNK activation in neutrophils. Wortmannin 48-58 C-C motif chemokine ligand 2 Homo sapiens 110-115 15084916-5 2004 When FLSs were co-cultured with CII-stimulated T cells, the production of interleukin-8, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1alpha was significantly enhanced. N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide 32-35 C-C motif chemokine ligand 2 Homo sapiens 89-123 15077296-6 2004 IL-8, MCP-1, and MIP-1 alpha levels in SF were strongly correlated with T cell responses to CII. N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide 92-95 C-C motif chemokine ligand 2 Homo sapiens 6-11 15077296-7 2004 When FLS were cocultured with CII-stimulated T cells, the production of IL-8, MCP-1, and MIP-1 alpha was significantly increased. N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide 30-33 C-C motif chemokine ligand 2 Homo sapiens 78-83 15077296-10 2004 CONCLUSION: Our data indicate that the presence of CII-reactive T cells in RA joints can increase the production of chemokines such as IL-8, MCP-1, and MIP-1 alpha through interaction with FLS. N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide 51-54 C-C motif chemokine ligand 2 Homo sapiens 141-146 15077296-10 2004 CONCLUSION: Our data indicate that the presence of CII-reactive T cells in RA joints can increase the production of chemokines such as IL-8, MCP-1, and MIP-1 alpha through interaction with FLS. CHEMBL1232769 189-192 C-C motif chemokine ligand 2 Homo sapiens 141-146 15081318-0 2004 Regulation of monocyte chemoattractant protein-1 by the oxidized lipid, 13-hydroperoxyoctadecadienoic acid, in vascular smooth muscle cells via nuclear factor-kappa B (NF-kappa B). 13-Hydroperoxyoctadecadienoic acid 72-106 C-C motif chemokine ligand 2 Homo sapiens 14-48 15081318-3 2004 In this study, we showed that the 12/15-LO product of linoleic acid, 13-hydroperoxyocta decadienoic acid (13-HPODE) can transcriptionally upregulate the expression of the chemokine monocyte chemoattractant protein-1 (MCP-1) in VSMC. Linoleic Acid 54-67 C-C motif chemokine ligand 2 Homo sapiens 181-215 15081318-3 2004 In this study, we showed that the 12/15-LO product of linoleic acid, 13-hydroperoxyocta decadienoic acid (13-HPODE) can transcriptionally upregulate the expression of the chemokine monocyte chemoattractant protein-1 (MCP-1) in VSMC. Linoleic Acid 54-67 C-C motif chemokine ligand 2 Homo sapiens 217-222 15081318-3 2004 In this study, we showed that the 12/15-LO product of linoleic acid, 13-hydroperoxyocta decadienoic acid (13-HPODE) can transcriptionally upregulate the expression of the chemokine monocyte chemoattractant protein-1 (MCP-1) in VSMC. 13-hydroperoxyocta decadienoic acid 69-104 C-C motif chemokine ligand 2 Homo sapiens 181-215 15081318-3 2004 In this study, we showed that the 12/15-LO product of linoleic acid, 13-hydroperoxyocta decadienoic acid (13-HPODE) can transcriptionally upregulate the expression of the chemokine monocyte chemoattractant protein-1 (MCP-1) in VSMC. 13-hydroperoxyocta decadienoic acid 69-104 C-C motif chemokine ligand 2 Homo sapiens 217-222 15081318-11 2004 These results show for the first time that 13-HPODE can induce MCP-1 in the vasculature via activation of NF-kappa B. 13(S)-HPODE 46-51 C-C motif chemokine ligand 2 Homo sapiens 63-68 15022320-13 2004 PD 98059, fludarabine, piceatannol, and curcumin (AP-1 inhibitor) inhibited the OSM-induced expression of CCL2. fludarabine 10-21 C-C motif chemokine ligand 2 Homo sapiens 106-110 15022320-13 2004 PD 98059, fludarabine, piceatannol, and curcumin (AP-1 inhibitor) inhibited the OSM-induced expression of CCL2. 3,3',4,5'-tetrahydroxystilbene 23-34 C-C motif chemokine ligand 2 Homo sapiens 106-110 15022320-13 2004 PD 98059, fludarabine, piceatannol, and curcumin (AP-1 inhibitor) inhibited the OSM-induced expression of CCL2. Curcumin 40-48 C-C motif chemokine ligand 2 Homo sapiens 106-110 14993777-0 2004 Epoprostenol therapy decreases elevated circulating levels of monocyte chemoattractant protein-1 in patients with primary pulmonary hypertension. Epoprostenol 0-12 C-C motif chemokine ligand 2 Homo sapiens 62-96 14993777-8 2004 CONCLUSIONS: Circulating MCP-1 concentrations are increased in PPH patients, but can alleviated by chronic intravenous epoprostenol therapy. Epoprostenol 119-131 C-C motif chemokine ligand 2 Homo sapiens 25-30 14736953-0 2004 Dexamethasone regulates AP-1 to repress TNF-alpha induced MCP-1 production in human glomerular endothelial cells. Dexamethasone 0-13 C-C motif chemokine ligand 2 Homo sapiens 58-63 14767486-3 2004 Transfection with CSF1R mutated to express phe at the tyr-721 autophosphorylation site (HC11-CSF1R-721) creates a phenotype that lacks metastastic competence but maintains local invasiveness. Phenylalanine 43-46 C-C motif chemokine ligand 2 Homo sapiens 88-92 14767486-3 2004 Transfection with CSF1R mutated to express phe at the tyr-721 autophosphorylation site (HC11-CSF1R-721) creates a phenotype that lacks metastastic competence but maintains local invasiveness. Tyrosine 54-57 C-C motif chemokine ligand 2 Homo sapiens 88-92 14767486-4 2004 Conversely, HC11 cells transfected with CSF1R mutated at tyr-807 (HC11-CSF1R-807) retain their metastatic competence, but are not locally invasive. Tyrosine 57-60 C-C motif chemokine ligand 2 Homo sapiens 12-16 14767486-4 2004 Conversely, HC11 cells transfected with CSF1R mutated at tyr-807 (HC11-CSF1R-807) retain their metastatic competence, but are not locally invasive. Tyrosine 57-60 C-C motif chemokine ligand 2 Homo sapiens 66-70 14962280-11 2004 In conclusion, MCP-1 secreted by APIs may contribute to both IBMIR and rejection by attracting monocytes into the islet; monocytes which upon transformation into macrophages will potentiate antigen presentation and execute islet rejection. apis 33-37 C-C motif chemokine ligand 2 Homo sapiens 15-20 14871094-1 2004 Large parity violation effects of the order of 1 Hz are predicted for the vibrational spectrum of two organometallic species, Os(eta5-C5H5)(=CCl2)Cl(PH3) and Re(eta5-Cp*)(=O)(CH3)Cl. Osmium 126-128 C-C motif chemokine ligand 2 Homo sapiens 141-145 14871094-1 2004 Large parity violation effects of the order of 1 Hz are predicted for the vibrational spectrum of two organometallic species, Os(eta5-C5H5)(=CCl2)Cl(PH3) and Re(eta5-Cp*)(=O)(CH3)Cl. eta5-c5h5 129-138 C-C motif chemokine ligand 2 Homo sapiens 141-145 14734750-9 2004 Finally, we found that the triptophan catabolite picolinic acid and the iron chelator desferrioxamine, which mimic hypoxia in the induction of gene expression, differentially regulated the expression of MCP-1. triptophan 27-37 C-C motif chemokine ligand 2 Homo sapiens 203-208 14734750-9 2004 Finally, we found that the triptophan catabolite picolinic acid and the iron chelator desferrioxamine, which mimic hypoxia in the induction of gene expression, differentially regulated the expression of MCP-1. catabolite 38-48 C-C motif chemokine ligand 2 Homo sapiens 203-208 14734750-9 2004 Finally, we found that the triptophan catabolite picolinic acid and the iron chelator desferrioxamine, which mimic hypoxia in the induction of gene expression, differentially regulated the expression of MCP-1. picolinic acid 49-63 C-C motif chemokine ligand 2 Homo sapiens 203-208 14734750-9 2004 Finally, we found that the triptophan catabolite picolinic acid and the iron chelator desferrioxamine, which mimic hypoxia in the induction of gene expression, differentially regulated the expression of MCP-1. Iron 72-76 C-C motif chemokine ligand 2 Homo sapiens 203-208 14734750-9 2004 Finally, we found that the triptophan catabolite picolinic acid and the iron chelator desferrioxamine, which mimic hypoxia in the induction of gene expression, differentially regulated the expression of MCP-1. Deferoxamine 86-101 C-C motif chemokine ligand 2 Homo sapiens 203-208 15203564-9 2004 Serum MCP-1 correlated with cholesterol, triglycerides, low-density lipoprotein but not high-density lipoprotein. Cholesterol 28-39 C-C motif chemokine ligand 2 Homo sapiens 6-11 15203564-9 2004 Serum MCP-1 correlated with cholesterol, triglycerides, low-density lipoprotein but not high-density lipoprotein. Triglycerides 41-54 C-C motif chemokine ligand 2 Homo sapiens 6-11 15074399-0 2004 Alcohol modulates circulating levels of interleukin-6 and monocyte chemoattractant protein-1 in chronic pancreatitis. Alcohols 0-7 C-C motif chemokine ligand 2 Homo sapiens 58-92 14960322-0 2004 LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 0-8 C-C motif chemokine ligand 2 Homo sapiens 18-52 14960322-1 2004 The effects of LY294002 (LY29) and wortmannin (WM), inhibitors of phosphatidylinositol 3-kinase (PI3K), on monocyte chemoattractant protein-1 (MCP-1) expression by human umbilical vein endothelial cells were investigated. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 15-23 C-C motif chemokine ligand 2 Homo sapiens 107-141 14960322-4 2004 LY303511 (LY30), an inactive analogue of LY29, also inhibited MCP-1 expression. LY 303511 0-8 C-C motif chemokine ligand 2 Homo sapiens 62-67 14960322-4 2004 LY303511 (LY30), an inactive analogue of LY29, also inhibited MCP-1 expression. LY 303511 0-4 C-C motif chemokine ligand 2 Homo sapiens 62-67 14960322-6 2004 These results suggest that LY29 inhibits MCP-1 expression at least in part via suppression of NF-kappaB, independent of PI3K, and the structure of LY29 and LY30 may be a novel template for development of new anti-inflammatory drugs. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 27-31 C-C motif chemokine ligand 2 Homo sapiens 41-46 14736953-12 2004 (ii) Both NF-kappa B decoy oligodeoxynucleotide and AP-1 decoy oligodeoxynucleotide partially suppressed TNF-alpha induced MCP-1 mRNA expression. Oligodeoxyribonucleotides 27-47 C-C motif chemokine ligand 2 Homo sapiens 123-128 14736953-14 2004 CONCLUSIONS: These data demonstrate that while TNF-alpha induced MCP-1 production is mediated by the cooperative action of NF-kappa B and AP-1 in HGEC, dexamethasone represses TNF-alpha induced MCP-1 production via suppression of AP-1 binding activity. Dexamethasone 152-165 C-C motif chemokine ligand 2 Homo sapiens 194-199 14730659-9 2004 Similarly, maximal TA MCP-1, MCP-2, and MCP-3 but not MIP-1alpha and MIP-1beta concentrations were significantly higher in infants who were oxygen-dependent at 36 weeks of postconceptional age (PCA) than those who were not oxygen-dependent at 36 weeks PCA. Oxygen 140-146 C-C motif chemokine ligand 2 Homo sapiens 22-27 15268305-2 2004 Trichloroethene (ClCH=CCl2) and trans-2-butene (trans-CH3CH=CHCH3) were prepared in Rydberg states in the range of effective principal quantum number n* approximately 7-93 by VUV excitation prior to IR-induced autoionization. Trichloroethylene 0-15 C-C motif chemokine ligand 2 Homo sapiens 22-26 15268305-4 2004 The observed IR active C-H stretching vibrational frequencies nu12+ = 3072+/-5 cm(-1) for ClCH=CCl2+ and nu23+ =2908+/-3 cm(-1), nu25+ =2990+/-10 cm(-1) and nu30+ =3022+/-10 cm(-1) for trans-CH3CH=CHCH3+ are compared with predictions based on ab initio quantum-chemical procedures and density functional calculations. clch 90-94 C-C motif chemokine ligand 2 Homo sapiens 95-99 15553662-1 2004 We have previously shown that nifedipine, one of the most popular dihydropyridine-based calcium antagonists (DHPs), blocked tumor necrosis factor-alpha (TNF-alpha)-induced reactive oxygen species generation and subsequent monocyte chemoattractant protein-1 expression in endothelial cells (ECs), thus suggesting that nifedipine may inhibit monocyte recruitment, an initiating step in atherosclerosis. Nifedipine 30-40 C-C motif chemokine ligand 2 Homo sapiens 222-256 12855406-6 2004 NECA increased the release of interleukin-6 and monocyte chemotactic protein-1 proteins with EC50 values of 1.26 +/- 0.25 microM and 0.40 +/- 0.08 microM, respectively, and the maximal folds of induction were 20.8 +/- 1.7- and 6.4 +/- 0.7-fold, respectively. Adenosine-5'-(N-ethylcarboxamide) 0-4 C-C motif chemokine ligand 2 Homo sapiens 48-78 12855406-9 2004 Thus, Ado increases the release of interleukin-6 and monocyte chemotactic protein-1 from bronchial smooth muscle cells via activation of the A2B AdoR. Adenosine 6-9 C-C motif chemokine ligand 2 Homo sapiens 53-83 14681721-0 2004 hTERT-promoter-based tumor-specific expression of MCP-1 effectively sensitizes cervical cancer cells to a low dose of cisplatin. Cisplatin 118-127 C-C motif chemokine ligand 2 Homo sapiens 50-55 14681721-7 2004 However, when combined with a suboptimal low dose of cisplatin, tumor formation was obviously reduced in clones transduced with MCP-1, but not in control clones. Cisplatin 53-62 C-C motif chemokine ligand 2 Homo sapiens 128-133 14681721-9 2004 These findings suggest that MCP-1 expression sensitizes cervical cancer cells to an otherwise ineffective low dose of cisplatin, possibly by inducing the migration of macrophages to eradicate tumor cells. Cisplatin 118-127 C-C motif chemokine ligand 2 Homo sapiens 28-33 15553662-1 2004 We have previously shown that nifedipine, one of the most popular dihydropyridine-based calcium antagonists (DHPs), blocked tumor necrosis factor-alpha (TNF-alpha)-induced reactive oxygen species generation and subsequent monocyte chemoattractant protein-1 expression in endothelial cells (ECs), thus suggesting that nifedipine may inhibit monocyte recruitment, an initiating step in atherosclerosis. dhps 109-113 C-C motif chemokine ligand 2 Homo sapiens 222-256 15553663-3 2004 We have previously shown that nifedipine, one of the most popular dihydropyridine-based calcium antagonists, blocked tumor necrosis factor-alpha-induced monocyte chemoattractant protein-1 expression in endothelial cells (ECs) through its antioxidative properties. Nifedipine 30-40 C-C motif chemokine ligand 2 Homo sapiens 153-187 15553663-3 2004 We have previously shown that nifedipine, one of the most popular dihydropyridine-based calcium antagonists, blocked tumor necrosis factor-alpha-induced monocyte chemoattractant protein-1 expression in endothelial cells (ECs) through its antioxidative properties. 1,4-dihydropyridine 66-81 C-C motif chemokine ligand 2 Homo sapiens 153-187 15553662-1 2004 We have previously shown that nifedipine, one of the most popular dihydropyridine-based calcium antagonists (DHPs), blocked tumor necrosis factor-alpha (TNF-alpha)-induced reactive oxygen species generation and subsequent monocyte chemoattractant protein-1 expression in endothelial cells (ECs), thus suggesting that nifedipine may inhibit monocyte recruitment, an initiating step in atherosclerosis. 1,4-dihydropyridine 66-81 C-C motif chemokine ligand 2 Homo sapiens 222-256 15553663-3 2004 We have previously shown that nifedipine, one of the most popular dihydropyridine-based calcium antagonists, blocked tumor necrosis factor-alpha-induced monocyte chemoattractant protein-1 expression in endothelial cells (ECs) through its antioxidative properties. Calcium 88-95 C-C motif chemokine ligand 2 Homo sapiens 153-187 15553662-1 2004 We have previously shown that nifedipine, one of the most popular dihydropyridine-based calcium antagonists (DHPs), blocked tumor necrosis factor-alpha (TNF-alpha)-induced reactive oxygen species generation and subsequent monocyte chemoattractant protein-1 expression in endothelial cells (ECs), thus suggesting that nifedipine may inhibit monocyte recruitment, an initiating step in atherosclerosis. Calcium 88-95 C-C motif chemokine ligand 2 Homo sapiens 222-256 15550762-0 2004 Steroid therapy altered serum levels of CCL2 and CCL5 chemokines in multiple sclerosis patients during relapse. Steroids 0-7 C-C motif chemokine ligand 2 Homo sapiens 40-44 15550762-2 2004 The aim of this study was to determine the impact of steroid therapy on the levels of CCL2 and CCL5 chemokines. Steroids 53-60 C-C motif chemokine ligand 2 Homo sapiens 86-90 15550762-7 2004 After the methylprednisolone treatment, the chemokine levels changed significantly: the levels of CCL2 increased, whilst the levels of CCL5 decreased. Methylprednisolone 10-28 C-C motif chemokine ligand 2 Homo sapiens 98-102 14688370-3 2004 Interestingly, this chemokine antagonizes transendothelial migration and chemotaxis of MonoMac6 cells and freshly isolated human monocytes induced by MCP-1, indicating a direct effect of s-FKN on monocytic cells. s-fkn 187-192 C-C motif chemokine ligand 2 Homo sapiens 150-155 15209534-3 2004 In this study we examined the levels of soluble forms of E-, P-selectin and monocyte chemotactic protein (MCP-1) in the process of extracorporeal cholesterol elimination by LDL-apheresis. Cholesterol 146-157 C-C motif chemokine ligand 2 Homo sapiens 106-111 14647401-5 2004 Dual color immunofluorescence analysis demonstrated that MCP-1 was focused into heparan sulfate-containing domains on the apical surface of some of the endothelial cells. Heparitin Sulfate 80-95 C-C motif chemokine ligand 2 Homo sapiens 57-62 14694519-5 2004 In paraffin sections, cells that expressed IL-6 or MCP-1 were identified by combined in situ hybridization and immunohistochemistry. Paraffin 3-11 C-C motif chemokine ligand 2 Homo sapiens 51-56 15209534-8 2004 The levels of P-selectin and MCP-1 decreased significantly after the hypolidemic procedure and could be used as another marker showing the effectivity of the extracorporeal LDL-cholesterol elimination (immediately after the procedure), and, after further verification, may serve as a marker for controlling the therapy efficacy. Cholesterol 177-188 C-C motif chemokine ligand 2 Homo sapiens 29-34 14588154-5 2003 By influencing the activity of p38 mitogen-activated protein kinase and AKT, NADPH oxidase-derived O(2) .- increases the expression of several pro-arteriosclerotic genes, such as monocyte chemoattractant protein-1, tissue factor, and vascular endothelial growth factor. Superoxides 99-103 C-C motif chemokine ligand 2 Homo sapiens 179-213 14615068-6 2003 As results, retinoid-induced inflammation was mainly mediated through MCP-1 and IL-8 as evidenced by increased levels of mRNA expression and protein secretion. Retinoids 12-20 C-C motif chemokine ligand 2 Homo sapiens 70-75 14615068-9 2003 Most of the substances that reduced the secretion of MCP-1 and IL-8 in vitro cultured fibroblasts, showed a good inhibition against the retinol-induced irritation in the rabbit and human patch test. Vitamin A 136-143 C-C motif chemokine ligand 2 Homo sapiens 53-58 14615068-10 2003 In conclusion, the present study demonstrated that among proinflammatory cytokines, MCP-1 and IL-8 mainly mediated retinol-induced skin irritation, and that inhibition of production of these cytokines can be applied as good markers to screen the anti-irritants against the retinol-induced irritation. Vitamin A 115-122 C-C motif chemokine ligand 2 Homo sapiens 84-89 14615068-10 2003 In conclusion, the present study demonstrated that among proinflammatory cytokines, MCP-1 and IL-8 mainly mediated retinol-induced skin irritation, and that inhibition of production of these cytokines can be applied as good markers to screen the anti-irritants against the retinol-induced irritation. Vitamin A 273-280 C-C motif chemokine ligand 2 Homo sapiens 84-89 14637261-0 2003 Atorvastatin reduces plasma MCP-1 in patients with acute coronary syndrome. Atorvastatin 0-12 C-C motif chemokine ligand 2 Homo sapiens 28-33 14637261-4 2003 We investigated the effects of atorvastatin therapy on plasma MCP-1 concentrations and production of MCP-1 released by peripheral blood monocytes from ACS patients. Atorvastatin 31-43 C-C motif chemokine ligand 2 Homo sapiens 62-67 14637261-10 2003 Compared with conventional therapy alone, atorvastatin significantly further reduced plasma MCP-1 concentrations. Atorvastatin 42-54 C-C motif chemokine ligand 2 Homo sapiens 92-97 14637261-12 2003 In vitro, atorvastatin inhibits production of MCP-1 up to 73%, in a concentration-dependent manner, and suppressed MCP-1 expression in peripheral blood monocytes. Atorvastatin 10-22 C-C motif chemokine ligand 2 Homo sapiens 46-51 14637261-12 2003 In vitro, atorvastatin inhibits production of MCP-1 up to 73%, in a concentration-dependent manner, and suppressed MCP-1 expression in peripheral blood monocytes. Atorvastatin 10-22 C-C motif chemokine ligand 2 Homo sapiens 115-120 14637261-13 2003 CONCLUSIONS: Atorvastatin reduced plasma MCP-1 concentrations in patients with ACS. Atorvastatin 13-25 C-C motif chemokine ligand 2 Homo sapiens 41-46 14627904-5 2003 RESULTS: Nicotinamide was the only compound that significantly reduced both TF and MCP-1. Niacinamide 9-21 C-C motif chemokine ligand 2 Homo sapiens 83-88 14604680-6 2003 Xanthone (1,3,5,6-tetrahydroxyxanthone) (1, 3 or 10 micromol/L) significantly inhibited the increased adhesion of monocytes to endothelial cells and attenuated the increased levels of LDH, MCP-1 and ADMA induced by ox-LDL. xanthone 0-8 C-C motif chemokine ligand 2 Homo sapiens 189-194 14604680-6 2003 Xanthone (1,3,5,6-tetrahydroxyxanthone) (1, 3 or 10 micromol/L) significantly inhibited the increased adhesion of monocytes to endothelial cells and attenuated the increased levels of LDH, MCP-1 and ADMA induced by ox-LDL. 1,3,5,6-tetrahydroxyxanthone 10-38 C-C motif chemokine ligand 2 Homo sapiens 189-194 14611909-9 2003 Levels of MIP-1beta and MCP-1 correlated with disease activity in some patients and with prednisolone levels in patients on this treatment alone. Prednisolone 89-101 C-C motif chemokine ligand 2 Homo sapiens 24-29 14611909-12 2003 Longitudinal analysis suggested that MIP-1beta and MCP-1 levels were controlled by drug treatment, particularly prednisolone. Prednisolone 112-124 C-C motif chemokine ligand 2 Homo sapiens 51-56 14627904-9 2003 CONCLUSIONS: TF and MCP-1 expression in human islets can be decreased by adding nicotinamide to the culture medium. Niacinamide 80-92 C-C motif chemokine ligand 2 Homo sapiens 20-25 14605496-7 2003 Monocyte chemoattractant protein-1 synthesis by cells exposed to glucose was increased by 31% (p < 001), and again that effect was prevented by OTZ. Glucose 65-72 C-C motif chemokine ligand 2 Homo sapiens 0-34 14692429-8 2003 The immunoregulatory effects of amphotericin B include increases in apoptosis, production of monocyte chemoattractant protein 1, superoxide anion, nitric oxide, and intercellular adhesion molecule 1 expression. Amphotericin B 32-46 C-C motif chemokine ligand 2 Homo sapiens 93-127 14570645-0 2003 Lidocaine attenuates monocyte chemoattractant protein-1 production and chemotaxis in human monocytes: possible mechanisms for its effect on inflammation. Lidocaine 0-9 C-C motif chemokine ligand 2 Homo sapiens 21-55 14570645-3 2003 In this study, we examined the effect of lidocaine on lipopolysaccharide-stimulated MCP-1 secretion and MCP-1 induced chemotaxis in a human monocytic cell line, THP-1. Lidocaine 41-50 C-C motif chemokine ligand 2 Homo sapiens 84-89 14585060-6 2003 AGI-1067 inhibited the TNF-alpha induction of redox-sensitive inflammatory proteins, vascular cell adhesion molecule-1, monocyte chemoattractant protein-1 and Eselectin, in cell culture. succinobucol 0-8 C-C motif chemokine ligand 2 Homo sapiens 120-154 14570645-4 2003 Lidocaine inhibited lipopolysaccharide-induced MCP-1 production as well as messenger RNA expression in a dose-dependent manner. Lidocaine 0-9 C-C motif chemokine ligand 2 Homo sapiens 47-52 14570645-5 2003 Furthermore, we demonstrated that lidocaine suppressed MCP-1-induced chemotaxis and peak cytosolic-free calcium in THP-1 cells. Lidocaine 34-43 C-C motif chemokine ligand 2 Homo sapiens 55-60 14570645-5 2003 Furthermore, we demonstrated that lidocaine suppressed MCP-1-induced chemotaxis and peak cytosolic-free calcium in THP-1 cells. Calcium 104-111 C-C motif chemokine ligand 2 Homo sapiens 55-60 14570645-6 2003 These results suggest that lidocaine may modulate MCP-1 production and MCP-1-induced activation in inflammatory cells. Lidocaine 27-36 C-C motif chemokine ligand 2 Homo sapiens 50-55 14570645-6 2003 These results suggest that lidocaine may modulate MCP-1 production and MCP-1-induced activation in inflammatory cells. Lidocaine 27-36 C-C motif chemokine ligand 2 Homo sapiens 71-76 14570645-8 2003 Lidocaine may modulate MCP-1-induced monocyte response, as reflected by chemotaxis, cytosolic-free calcium, and lipopolysaccharide-induced MCP-1 production by human monocytic THP-1 cells. Lidocaine 0-9 C-C motif chemokine ligand 2 Homo sapiens 23-28 14570645-8 2003 Lidocaine may modulate MCP-1-induced monocyte response, as reflected by chemotaxis, cytosolic-free calcium, and lipopolysaccharide-induced MCP-1 production by human monocytic THP-1 cells. Lidocaine 0-9 C-C motif chemokine ligand 2 Homo sapiens 139-144 14570645-8 2003 Lidocaine may modulate MCP-1-induced monocyte response, as reflected by chemotaxis, cytosolic-free calcium, and lipopolysaccharide-induced MCP-1 production by human monocytic THP-1 cells. Calcium 99-106 C-C motif chemokine ligand 2 Homo sapiens 23-28 12908082-0 2003 Induction of TNF-alpha, uPA, IL-8 and MCP-1 by doxorubicin in human lung carcinoma cells. Doxorubicin 47-58 C-C motif chemokine ligand 2 Homo sapiens 38-43 12908082-2 2003 The microarray analysis also revealed a significant induction of tumor necrosis factor-alpha (TNF-alpha), and doxorubicin-induced macrophage chemoattractant protein-1 (MCP-1) expression was demonstrated by an RNase protection assay. Doxorubicin 110-121 C-C motif chemokine ligand 2 Homo sapiens 130-166 12908082-2 2003 The microarray analysis also revealed a significant induction of tumor necrosis factor-alpha (TNF-alpha), and doxorubicin-induced macrophage chemoattractant protein-1 (MCP-1) expression was demonstrated by an RNase protection assay. Doxorubicin 110-121 C-C motif chemokine ligand 2 Homo sapiens 168-173 14728887-13 2003 CONCLUSION: Curcumin could inhibit the human mesangial cell proliferation and alter the extracellular matrix turnover, meanwhile it could down-regulate the IL-1 beta and MCP-1 mRNA expression induced by LPS, which may be valuable in decreasing the progression of glomerulosclerosis. Curcumin 12-20 C-C motif chemokine ligand 2 Homo sapiens 170-175 14596794-1 2003 The role of lysophosphatidylcholine (LPC) in the induction of MCP-1, IL-8 and RANTES, which are chemotactic factors to monocytes, neutrophils and lymphocytes, respectively, by human vascular endothelial cells (EC), was examined. Lysophosphatidylcholines 12-35 C-C motif chemokine ligand 2 Homo sapiens 62-67 14596794-1 2003 The role of lysophosphatidylcholine (LPC) in the induction of MCP-1, IL-8 and RANTES, which are chemotactic factors to monocytes, neutrophils and lymphocytes, respectively, by human vascular endothelial cells (EC), was examined. Lysophosphatidylcholines 37-40 C-C motif chemokine ligand 2 Homo sapiens 62-67 14596794-2 2003 LPC induced the expression of MCP-1 and IL-8 in a concentration- and time-dependent manner in microvascular EC (MVEC) and in large vessel EC from aorta, pulmonary artery and umbilical vein. Lysophosphatidylcholines 0-3 C-C motif chemokine ligand 2 Homo sapiens 30-35 14652683-7 2003 Treatment with actinomycin D showed that hypoxic down-regulation of MCP-1 expression was due to a decrease in transcription, since the half-life of MCP-1 mRNA was unchanged. Dactinomycin 15-28 C-C motif chemokine ligand 2 Homo sapiens 68-73 14652683-9 2003 The decrease in MCP-1 expression by hypoxia was mimicked by cobalt chloride in unstimulated RASF with no effect on IL-1beta-activated MCP-1, suggesting differences in the signaling mechanisms. cobaltous chloride 60-75 C-C motif chemokine ligand 2 Homo sapiens 16-21 14652683-11 2003 CONCLUSION: Hypoxia regulates MCP-1 expression under both basal and cytokine-stimulated conditions, suggesting that reduced oxygen supply is an important factor that mediates chemotaxis of monocytes to the area of inflammation. Oxygen 124-130 C-C motif chemokine ligand 2 Homo sapiens 30-35 15182651-2 2003 METHODS: Urinary MCP-1 level was detected by avidin biotin complex(ABC)ELISA. Biotin 52-58 C-C motif chemokine ligand 2 Homo sapiens 17-22 12946945-2 2003 In this study, we demonstrate that Fas/FADD-induced MCP-1 upregulation is driven by an autocrine/paracrine signaling loop in which interleukin (IL)-1alpha synthesis and release are activated through caspase- and calpain-dependent processes. ammonium ferrous sulfate 35-38 C-C motif chemokine ligand 2 Homo sapiens 52-57 12805068-3 2003 Infection of monocyte-derived macrophages with laboratory-adapted HIV-1 or primary viral isolates in the continuous presence of anti-CCL2 antibody resulted in significantly lower p24 Gag antigen release with respect to control cultures. Glycosaminoglycans 183-186 C-C motif chemokine ligand 2 Homo sapiens 133-137 12805068-4 2003 Interestingly, CCL2 neutralization did not affect the early steps of the HIV life cycle but resulted in the intracellular accumulation of p24 Gag antigen. Glycosaminoglycans 142-145 C-C motif chemokine ligand 2 Homo sapiens 15-19 14514736-5 2003 In group 1 (n = 13), urine MCP-1 excretion (136 +/- 14 pg/mg creatinine) was not different from normal volunteers (152 +/- 16 pg/mg); serum creatinine levels and urine total protein excretion were normal as well. Creatinine 61-71 C-C motif chemokine ligand 2 Homo sapiens 27-32 14514736-6 2003 In group 2 (n = 27), urine MCP-1 excretion was increased (525 +/- 39 pg/mg creatinine), but serum creatinine levels and urine protein excretion were not different from normal. Creatinine 75-85 C-C motif chemokine ligand 2 Homo sapiens 27-32 12946945-10 2003 These data suggest that calpains play a dominant role in Fas/FADD-induced IL-1alpha release and MCP-1 upregulation and that caspase activation may function to amplify the effects of calpain activation. ammonium ferrous sulfate 57-60 C-C motif chemokine ligand 2 Homo sapiens 96-101 12816876-5 2003 Three- to 4-fold increases in MCP-1 and IL-8 release were observed at endotoxin concentrations of 100 pg/mL; these increases were inhibited by the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin. Atorvastatin 205-217 C-C motif chemokine ligand 2 Homo sapiens 30-35 12957441-8 2003 However, compared with placebo, candesartan significantly reduced plasma levels of malondialdehyde from 1.50 +/- 0.07 to 1.29 +/- 0.09 microM (p = 0.009); improved the percent flow-mediated dilator response to hyperemia from 5.17 +/- 0.24 to 6.22 +/- 0.26% (p < 0.001); and, furthermore, reduced plasma levels of monocyte chemoattractant protein (MCP-1) from 213 +/- 8 to 190 +/- 7 pg/ml (p = 0.003), tumor necrosis factor-alpha from 2.93 to 2.22 pg/ml (p = 0.026), and plasminogen activator inhibitor type 1 from 74 +/- 4 to 53 +/- 4 ng/ml (p < 0.001) but not C-reactive protein (CRP), matrix metalloproteinase protein, and fibrinogen. candesartan 32-43 C-C motif chemokine ligand 2 Homo sapiens 350-355 12765881-6 2003 DMPS and TPEN specifically inhibited the production of eotaxin, regulated on activation, normal T-cell expressed, and presumably secreted, and monocyte chemotactic protein-1 in TNF-alpha-stimulated respiratory epithelial cells and fibroblasts through labile zinc chelation. Unithiol 0-4 C-C motif chemokine ligand 2 Homo sapiens 143-173 12765881-6 2003 DMPS and TPEN specifically inhibited the production of eotaxin, regulated on activation, normal T-cell expressed, and presumably secreted, and monocyte chemotactic protein-1 in TNF-alpha-stimulated respiratory epithelial cells and fibroblasts through labile zinc chelation. N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine 9-13 C-C motif chemokine ligand 2 Homo sapiens 143-173 12881478-0 2003 Homocysteine mediated expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human monocytes. Homocysteine 0-12 C-C motif chemokine ligand 2 Homo sapiens 50-84 12881478-8 2003 These data indicate that pathophysiological levels of Hcy can alter human monocyte function by upregulating MCP-1 and IL-8 expression and secretion via enhanced formation of intracellular ROS originated from NAD(P)H oxidase source via calmodulin or protein kinase C signaling pathways and that Hcy-induced ROS subsequently activates mitogen-activated protein kinase (p38 and ERK1/2) and nuclear factor-kappaB in a PPARgamma activator-sensitive manner. Homocysteine 54-57 C-C motif chemokine ligand 2 Homo sapiens 108-113 12881478-5 2003 We found that clinically relevant levels of Hcy (10 to 1000 micromol/L) increased the protein secretion and mRNA expression as well as activity of MCP-1 and IL-8 in cultured primary human monocytes. Homocysteine 44-47 C-C motif chemokine ligand 2 Homo sapiens 147-152 12954370-0 2003 Dilazep and fenofibric acid inhibit MCP-1 mRNA expression in glycoxidized LDL-stimulated human endothelial cells. Dilazep 0-7 C-C motif chemokine ligand 2 Homo sapiens 36-41 12954370-0 2003 Dilazep and fenofibric acid inhibit MCP-1 mRNA expression in glycoxidized LDL-stimulated human endothelial cells. fenofibric acid 12-27 C-C motif chemokine ligand 2 Homo sapiens 36-41 12954370-3 2003 Both 10 microg/ml dilazep and 100 microM fenofibric acid abrogated MCP-1 mRNA expression. Dilazep 18-25 C-C motif chemokine ligand 2 Homo sapiens 67-72 12954370-3 2003 Both 10 microg/ml dilazep and 100 microM fenofibric acid abrogated MCP-1 mRNA expression. fenofibric acid 41-56 C-C motif chemokine ligand 2 Homo sapiens 67-72 12952251-7 2003 Prostaglandin E2, known as an activator of the prostanoid receptors EP2 and EP4, which are positively coupled to adenylyl cyclase, also decreased the IL-1beta-induced eotaxin and MCP-1 production by 57+/-17 and 53+/-4%, respectively. Dinoprostone 0-16 C-C motif chemokine ligand 2 Homo sapiens 179-184 12928151-8 2003 Multivariate analyses on 64 study subjects of varying arsenic exposure levels showed that the association of CCL2/MCP1 plasma protein level with blood arsenic remained significant after adjustment for other risk factors of cardiovascular diseases. Arsenic 54-61 C-C motif chemokine ligand 2 Homo sapiens 109-113 12928151-8 2003 Multivariate analyses on 64 study subjects of varying arsenic exposure levels showed that the association of CCL2/MCP1 plasma protein level with blood arsenic remained significant after adjustment for other risk factors of cardiovascular diseases. Arsenic 54-61 C-C motif chemokine ligand 2 Homo sapiens 114-118 12928151-8 2003 Multivariate analyses on 64 study subjects of varying arsenic exposure levels showed that the association of CCL2/MCP1 plasma protein level with blood arsenic remained significant after adjustment for other risk factors of cardiovascular diseases. Arsenic 151-158 C-C motif chemokine ligand 2 Homo sapiens 109-113 12928151-8 2003 Multivariate analyses on 64 study subjects of varying arsenic exposure levels showed that the association of CCL2/MCP1 plasma protein level with blood arsenic remained significant after adjustment for other risk factors of cardiovascular diseases. Arsenic 151-158 C-C motif chemokine ligand 2 Homo sapiens 114-118 12952251-0 2003 Modulation by cAMP of IL-1beta-induced eotaxin and MCP-1 expression and release in human airway smooth muscle cells. Cyclic AMP 14-18 C-C motif chemokine ligand 2 Homo sapiens 51-56 12952251-3 2003 In this study, the authors investigated whether eotaxin and MCP-1 expression and release in human airway smooth muscle cells could be modulated by an increase in intracellular cyclic adenosine monophosphate (cAMP) concentration. Cyclic AMP 176-206 C-C motif chemokine ligand 2 Homo sapiens 60-65 12952251-3 2003 In this study, the authors investigated whether eotaxin and MCP-1 expression and release in human airway smooth muscle cells could be modulated by an increase in intracellular cyclic adenosine monophosphate (cAMP) concentration. Cyclic AMP 208-212 C-C motif chemokine ligand 2 Homo sapiens 60-65 12626343-1 2003 Peroxynitrite, formed by nitric oxide and superoxide, has been shown to nitrate and reduce the function of proinflammatory proteins such as interleukin (IL)-8, monocyte chemoattractant protein-1, and eotaxin, but in contrast, to enhance the function of the anti-inflammatory cytokine IL-10 in reducing IL-1 release from blood monocytes. Peroxynitrous Acid 0-13 C-C motif chemokine ligand 2 Homo sapiens 160-194 12882873-9 2003 Urinary MCP-1 levels decreased from 0.456 +/- 0.22 ng/mg creatinine to 0.08 +/- 0.096 ng/mg creatinine. Creatinine 57-67 C-C motif chemokine ligand 2 Homo sapiens 8-13 12882873-9 2003 Urinary MCP-1 levels decreased from 0.456 +/- 0.22 ng/mg creatinine to 0.08 +/- 0.096 ng/mg creatinine. Creatinine 92-102 C-C motif chemokine ligand 2 Homo sapiens 8-13 12952251-5 2003 Forskolin, a direct stimulator of adenylyl cyclase, decreased the interleukin (IL)-1beta-induced eotaxin and MCP-1 release by 73+/-8 and 65+/-6%, respectively. Colforsin 0-9 C-C motif chemokine ligand 2 Homo sapiens 109-114 12952251-6 2003 8Bromo-cAMP, a cAMP analogue, similarly decreased the chemokine production by 58+/-9 and 63+/-8% for eotaxin and MCP-1, respectively. 8-Bromo Cyclic Adenosine Monophosphate 0-11 C-C motif chemokine ligand 2 Homo sapiens 113-118 12952251-6 2003 8Bromo-cAMP, a cAMP analogue, similarly decreased the chemokine production by 58+/-9 and 63+/-8% for eotaxin and MCP-1, respectively. Cyclic AMP 7-11 C-C motif chemokine ligand 2 Homo sapiens 113-118 12952251-8 2003 H-89, an inhibitor of PKA, was able to inhibit the decrease in eotaxin and MCP-1 protein release induced by forskolin. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide 0-4 C-C motif chemokine ligand 2 Homo sapiens 75-80 12952251-8 2003 H-89, an inhibitor of PKA, was able to inhibit the decrease in eotaxin and MCP-1 protein release induced by forskolin. Colforsin 108-117 C-C motif chemokine ligand 2 Homo sapiens 75-80 12952251-10 2003 This study shows that an increase in intracellular cyclic adenosine monophosphate concentration may decrease the interleukin-1beta-induced eotaxin and monocyte chemotactic protein-1 expression and production. Cyclic AMP 51-81 C-C motif chemokine ligand 2 Homo sapiens 151-181 12883331-6 2003 These results demonstrate that homocysteine can trigger overexpression of the MCP-1 gene by altering the intracellular redox status, suggesting that the homocysteine-induced changes in the intracellular redox status play an important role in modulating the expression of MCP-l in endothelial cells. Homocysteine 31-43 C-C motif chemokine ligand 2 Homo sapiens 78-83 12883331-6 2003 These results demonstrate that homocysteine can trigger overexpression of the MCP-1 gene by altering the intracellular redox status, suggesting that the homocysteine-induced changes in the intracellular redox status play an important role in modulating the expression of MCP-l in endothelial cells. Homocysteine 153-165 C-C motif chemokine ligand 2 Homo sapiens 78-83 12883331-0 2003 Intracellular redox status modulates monocyte chemoattractant protein-1 expression stimulated by homocysteine in endothelial cells. Homocysteine 97-109 C-C motif chemokine ligand 2 Homo sapiens 37-71 12883331-4 2003 Homocysteine stimulated MCP-1 mRNA expression and protein production in a time-dependent and dose-dependent manner in endothelial cells, decreased intracellular glutathione (GSH) and protein thiol levels, as well as G6PDH activity and NADPH levels. Homocysteine 0-12 C-C motif chemokine ligand 2 Homo sapiens 24-29 12724308-9 2003 Further studies evaluating the calcium response that is triggered upon MCP-1 interaction with its receptor, CCR2, indicate that this response is not altered by antisense or sense ODN treatment, thus supporting our hypothesis that PKCbeta is critical for post-receptor signal transduction downstream of the immediate calcium signal. Calcium 31-38 C-C motif chemokine ligand 2 Homo sapiens 71-76 12883331-4 2003 Homocysteine stimulated MCP-1 mRNA expression and protein production in a time-dependent and dose-dependent manner in endothelial cells, decreased intracellular glutathione (GSH) and protein thiol levels, as well as G6PDH activity and NADPH levels. Glutathione 174-177 C-C motif chemokine ligand 2 Homo sapiens 24-29 12883331-4 2003 Homocysteine stimulated MCP-1 mRNA expression and protein production in a time-dependent and dose-dependent manner in endothelial cells, decreased intracellular glutathione (GSH) and protein thiol levels, as well as G6PDH activity and NADPH levels. NADP 235-240 C-C motif chemokine ligand 2 Homo sapiens 24-29 12885941-4 2003 Cells expressing this receptor show pertussis toxin-sensitive chemotaxis and small intracellular calcium transients in response to the chemokines CCL2, CCL7, CCL8, and CCL5. Calcium 97-104 C-C motif chemokine ligand 2 Homo sapiens 146-150 12939734-11 2003 In addition, gliclazide inhibits oxLDL-induced monocyte adhesion to cultured human aortic vascular smooth muscle cells (HASMCs) in vitro and reduces the production of monocyte chemotactic protein-1 (MCP-1) by these cells. Gliclazide 13-23 C-C motif chemokine ligand 2 Homo sapiens 167-197 12882449-2 2003 Therefore the current study investigated whether N-acetylcysteine (NAC), an antioxidative agent, inhibits the interleukin (IL)-1beta-induced expression and production of eotaxin and monocyte chemotactic protein (MCP)-1 in human airway smooth muscle cells (HASMC). Acetylcysteine 49-65 C-C motif chemokine ligand 2 Homo sapiens 182-218 12756509-0 2003 Effects of atorvastatin, simvastatin, and fenofibrate therapy on monocyte chemoattractant protein-1 secretion in patients with hyperlipidemia. Atorvastatin 11-23 C-C motif chemokine ligand 2 Homo sapiens 65-99 12756509-0 2003 Effects of atorvastatin, simvastatin, and fenofibrate therapy on monocyte chemoattractant protein-1 secretion in patients with hyperlipidemia. Simvastatin 25-36 C-C motif chemokine ligand 2 Homo sapiens 65-99 12756509-0 2003 Effects of atorvastatin, simvastatin, and fenofibrate therapy on monocyte chemoattractant protein-1 secretion in patients with hyperlipidemia. Fenofibrate 42-53 C-C motif chemokine ligand 2 Homo sapiens 65-99 12756509-2 2003 The aim of this study was to evaluate the secretion of monocyte chemoattractant protein-1 (MCP-1) by monocytes from hyperlipidemic patients treated with hypolipidemic drugs, namely fenofibrate, simvastatin, or atorvastatin to determine what role is played by these drugs in the development and stabilization of the atherosclerotic plaque. Fenofibrate 181-192 C-C motif chemokine ligand 2 Homo sapiens 55-89 12756509-2 2003 The aim of this study was to evaluate the secretion of monocyte chemoattractant protein-1 (MCP-1) by monocytes from hyperlipidemic patients treated with hypolipidemic drugs, namely fenofibrate, simvastatin, or atorvastatin to determine what role is played by these drugs in the development and stabilization of the atherosclerotic plaque. Simvastatin 194-205 C-C motif chemokine ligand 2 Homo sapiens 55-89 12756509-2 2003 The aim of this study was to evaluate the secretion of monocyte chemoattractant protein-1 (MCP-1) by monocytes from hyperlipidemic patients treated with hypolipidemic drugs, namely fenofibrate, simvastatin, or atorvastatin to determine what role is played by these drugs in the development and stabilization of the atherosclerotic plaque. Simvastatin 194-205 C-C motif chemokine ligand 2 Homo sapiens 91-96 12756509-2 2003 The aim of this study was to evaluate the secretion of monocyte chemoattractant protein-1 (MCP-1) by monocytes from hyperlipidemic patients treated with hypolipidemic drugs, namely fenofibrate, simvastatin, or atorvastatin to determine what role is played by these drugs in the development and stabilization of the atherosclerotic plaque. Atorvastatin 210-222 C-C motif chemokine ligand 2 Homo sapiens 55-89 12756509-2 2003 The aim of this study was to evaluate the secretion of monocyte chemoattractant protein-1 (MCP-1) by monocytes from hyperlipidemic patients treated with hypolipidemic drugs, namely fenofibrate, simvastatin, or atorvastatin to determine what role is played by these drugs in the development and stabilization of the atherosclerotic plaque. Atorvastatin 210-222 C-C motif chemokine ligand 2 Homo sapiens 91-96 12756509-11 2003 Fenofibrate, atorvastatin, and simvastatin significantly decreased MCP-1 levels from 15.8+/-0.47 to 8.79+/-0.89, from 16.7+/-0.23 to 7.46+/-0.73, and from 14.9+/-0.45 to 10.3+/-0.8 ng/ml, respectively. Fenofibrate 0-11 C-C motif chemokine ligand 2 Homo sapiens 67-72 12756509-11 2003 Fenofibrate, atorvastatin, and simvastatin significantly decreased MCP-1 levels from 15.8+/-0.47 to 8.79+/-0.89, from 16.7+/-0.23 to 7.46+/-0.73, and from 14.9+/-0.45 to 10.3+/-0.8 ng/ml, respectively. Atorvastatin 13-25 C-C motif chemokine ligand 2 Homo sapiens 67-72 12756509-11 2003 Fenofibrate, atorvastatin, and simvastatin significantly decreased MCP-1 levels from 15.8+/-0.47 to 8.79+/-0.89, from 16.7+/-0.23 to 7.46+/-0.73, and from 14.9+/-0.45 to 10.3+/-0.8 ng/ml, respectively. Simvastatin 31-42 C-C motif chemokine ligand 2 Homo sapiens 67-72 12882449-2 2003 Therefore the current study investigated whether N-acetylcysteine (NAC), an antioxidative agent, inhibits the interleukin (IL)-1beta-induced expression and production of eotaxin and monocyte chemotactic protein (MCP)-1 in human airway smooth muscle cells (HASMC). Acetylcysteine 67-70 C-C motif chemokine ligand 2 Homo sapiens 182-218 12882449-3 2003 NAC (10 mM) decreased the expression of eotaxin and MCP-1, by 46 +/- 11% (n=7) and 87 +/- 4% (n=6), respectively; the eotaxin release was inhibited by 75 +/- 5% (n=7), whereas the MCP-1 release was decreased by 69 +/- 41% (n=10). Acetylcysteine 0-3 C-C motif chemokine ligand 2 Homo sapiens 52-57 12882449-3 2003 NAC (10 mM) decreased the expression of eotaxin and MCP-1, by 46 +/- 11% (n=7) and 87 +/- 4% (n=6), respectively; the eotaxin release was inhibited by 75 +/- 5% (n=7), whereas the MCP-1 release was decreased by 69 +/- 41% (n=10). Acetylcysteine 0-3 C-C motif chemokine ligand 2 Homo sapiens 180-185 12882449-6 2003 The present study demonstrated that N-acetylcysteine inhibits the interleukin-1beta-induced eotaxin and monocyte chemotactic protein 1 expression and production due to a decreased activation of p38 mitogen-activated protein kinase. Acetylcysteine 36-52 C-C motif chemokine ligand 2 Homo sapiens 104-134 12854631-5 2003 We also observed a significant decrease in the expression and the release of eotaxin, MCP-1 and MCP-3 in the presence of SB203580, an inhibitor of p38 MAPK (71 +/- 6%, P < 0.05, n = 8 and 39 +/- 10% P < 0.01, n = 10 respectively), curcumin, an inhibitor of JNK kinase (83 +/- 4.9% and 88 +/- 3.4% respectively, P < 0.01, n = 4). SB 203580 121-129 C-C motif chemokine ligand 2 Homo sapiens 86-91 12818967-0 2003 Dobutamine inhibits monocyte chemoattractant protein-1 production and chemotaxis in human monocytes. Dobutamine 0-10 C-C motif chemokine ligand 2 Homo sapiens 20-54 12818967-2 2003 We conducted this study to investigate the effects of dobutamine and dopamine on lipopolysaccharide (LPS)-induced MCP-1 production in human monocytic THP-1 cells. Dobutamine 54-64 C-C motif chemokine ligand 2 Homo sapiens 114-119 12818967-5 2003 Dobutamine inhibited LPS-induced production of MCP-1, as well as messenger RNA expression, in a dose-dependent manner, whereas dopamine had no significant effect. Dobutamine 0-10 C-C motif chemokine ligand 2 Homo sapiens 47-52 12818967-6 2003 Furthermore, we demonstrated that dobutamine suppressed MCP-1-induced chemotaxis and peak [Ca(2+)](i) in monocytic THP-1 cells. Dobutamine 34-44 C-C motif chemokine ligand 2 Homo sapiens 56-61 12818967-7 2003 These findings suggest that dobutamine may modulate monocyte activation, such as chemotaxis and [Ca(2+)](i), as well as MCP-1 production, during therapy for congestive heart failure. Dobutamine 28-38 C-C motif chemokine ligand 2 Homo sapiens 120-125 12818967-9 2003 In this study, dobutamine was found to inhibit lipopolysaccharide-induced MCP-1 production and messenger RNA expression, as well as MCP-1-induced chemotaxis and peak [Ca(2+)](i), in human monocytes. Dobutamine 15-25 C-C motif chemokine ligand 2 Homo sapiens 74-79 12854631-7 2003 Pyrrolydine dithiocarbamate, an inhibitor of NF-kappaB was also able to reduce the eotaxin, MCP-1 and MCP-3 expression and production (50 +/- 13%, P < 0.05, n = 10 and 23 +/- 7%, P < 0.05, n = 12). pyrrolydine dithiocarbamate 0-27 C-C motif chemokine ligand 2 Homo sapiens 92-97 12805493-9 2003 The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor simvastatin inhibited the PTHrP(1-36) induction of both NF-kappaB activity and MCP-1 overexpression, and this was reversed by mevalonate. Simvastatin 62-73 C-C motif chemokine ligand 2 Homo sapiens 141-146 12743010-0 2003 Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Uric Acid 0-9 C-C motif chemokine ligand 2 Homo sapiens 21-55 12899782-11 2003 Antioxidant or SB 203580, a specific inhibitor of p38, could block the over-expression of MCP-1. SB 203580 15-24 C-C motif chemokine ligand 2 Homo sapiens 90-95 12743010-3 2003 Crystal- and endotoxin-free uric acid was found to increase VSMC monocyte chemoattractant protein-1 (MCP-1) expression in a time- and dose-dependent manner, peaking at 24 hours. Uric Acid 28-37 C-C motif chemokine ligand 2 Homo sapiens 65-99 12743010-3 2003 Crystal- and endotoxin-free uric acid was found to increase VSMC monocyte chemoattractant protein-1 (MCP-1) expression in a time- and dose-dependent manner, peaking at 24 hours. Uric Acid 28-37 C-C motif chemokine ligand 2 Homo sapiens 101-106 12743010-4 2003 Increased mRNA and protein expression occurred as early as 3 hours after uric acid incubation and was partially dependent on posttranscriptional modification of MCP-1 mRNA. Uric Acid 73-82 C-C motif chemokine ligand 2 Homo sapiens 161-166 12743010-6 2003 Inhibition of p38 (with SB 203580), ERK 44/42 (with UO126 or PD 98059), or COX-2 (with NS398) each significantly suppressed uric acid-induced MCP-1 expression at 24 hours, implicating these pathways in the response to uric acid. SB 203580 24-33 C-C motif chemokine ligand 2 Homo sapiens 142-147 12861395-8 2003 In addition, MCP-1 production of PPD- or 30-kDa antigen-stimulated monocytes was significantly elevated in CR-TB patients than that from E-TB. cr-tb 107-112 C-C motif chemokine ligand 2 Homo sapiens 13-18 12861395-8 2003 In addition, MCP-1 production of PPD- or 30-kDa antigen-stimulated monocytes was significantly elevated in CR-TB patients than that from E-TB. e-tb 137-141 C-C motif chemokine ligand 2 Homo sapiens 13-18 12743010-6 2003 Inhibition of p38 (with SB 203580), ERK 44/42 (with UO126 or PD 98059), or COX-2 (with NS398) each significantly suppressed uric acid-induced MCP-1 expression at 24 hours, implicating these pathways in the response to uric acid. Uric Acid 124-133 C-C motif chemokine ligand 2 Homo sapiens 142-147 12743010-6 2003 Inhibition of p38 (with SB 203580), ERK 44/42 (with UO126 or PD 98059), or COX-2 (with NS398) each significantly suppressed uric acid-induced MCP-1 expression at 24 hours, implicating these pathways in the response to uric acid. Uric Acid 218-227 C-C motif chemokine ligand 2 Homo sapiens 142-147 12743010-7 2003 The ability of both n-acetyl-cysteine and diphenyleneionium (antioxidants) to inhibit uric acid-induced MCP-1 production suggested involvement of intracellular redox pathways. Acetylcysteine 20-37 C-C motif chemokine ligand 2 Homo sapiens 104-109 12743010-7 2003 The ability of both n-acetyl-cysteine and diphenyleneionium (antioxidants) to inhibit uric acid-induced MCP-1 production suggested involvement of intracellular redox pathways. diphenyleneionium 42-59 C-C motif chemokine ligand 2 Homo sapiens 104-109 12816176-0 2003 Effects of fenofibrate and simvastatin on plasma sICAM-1 and MCP-1 concentrations in patients with hyperlipoproteinemia. Fenofibrate 11-22 C-C motif chemokine ligand 2 Homo sapiens 61-66 12743010-7 2003 The ability of both n-acetyl-cysteine and diphenyleneionium (antioxidants) to inhibit uric acid-induced MCP-1 production suggested involvement of intracellular redox pathways. Uric Acid 86-95 C-C motif chemokine ligand 2 Homo sapiens 104-109 12816176-0 2003 Effects of fenofibrate and simvastatin on plasma sICAM-1 and MCP-1 concentrations in patients with hyperlipoproteinemia. Simvastatin 27-38 C-C motif chemokine ligand 2 Homo sapiens 61-66 12787135-0 2003 17Beta-estradiol inhibits MCP-1 production in human keratinocytes. Estradiol 0-16 C-C motif chemokine ligand 2 Homo sapiens 26-31 12816176-10 2003 Fenofibrate (200 mg daily) significantly decreased sICAM-1 (by 17%) and MCP-1 levels (by 12.5%). Fenofibrate 0-11 C-C motif chemokine ligand 2 Homo sapiens 72-77 12704652-0 2003 Activation of PKC-epsilon and ERK1/2 participates in shear-induced endothelial MCP-1 expression that is repressed by nitric oxide. Nitric Oxide 117-129 C-C motif chemokine ligand 2 Homo sapiens 79-84 12704652-6 2003 Inhibition of ERK1/2 activation by PD98059 blocked MCP-1 induction. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 35-42 C-C motif chemokine ligand 2 Homo sapiens 51-56 12787135-4 2003 We examined in vitro effects of 17beta-estradiol (E2) on MCP-1 production by human keratinocytes. Estradiol 32-48 C-C motif chemokine ligand 2 Homo sapiens 57-62 12753088-0 2003 MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis. N-Methylaspartate 56-60 C-C motif chemokine ligand 2 Homo sapiens 0-5 12753088-0 2003 MCP-1 (CCL2) protects human neurons and astrocytes from NMDA or HIV-tat-induced apoptosis. N-Methylaspartate 56-60 C-C motif chemokine ligand 2 Homo sapiens 7-11 12787135-5 2003 E2 inhibited constitutive and 12-O-tetradecanoylphorbol-13-acetate-induced MCP-1 secretion, mRNA expression, and promoter activity in keratinocytes, and these effects of E2 were counteracted by estrogen receptor antagonist ICI 182 780. Tetradecanoylphorbol Acetate 30-66 C-C motif chemokine ligand 2 Homo sapiens 75-80 12753088-3 2003 Monocyte chemoattractant protein-1 (MCP-1 or CCL2) and regulated upon activation normal T cell expressed and secreted (RANTES) were found to protect mixed cultures of human neurons and astrocytes from tat or NMDA-induced apoptosis. N-Methylaspartate 208-212 C-C motif chemokine ligand 2 Homo sapiens 0-34 12753088-3 2003 Monocyte chemoattractant protein-1 (MCP-1 or CCL2) and regulated upon activation normal T cell expressed and secreted (RANTES) were found to protect mixed cultures of human neurons and astrocytes from tat or NMDA-induced apoptosis. N-Methylaspartate 208-212 C-C motif chemokine ligand 2 Homo sapiens 36-41 12787135-6 2003 GC-rich Sp1 element and activator protein 1 (AP-1) element on MCP-1 promoter were required for constitutive and 12-O-tetradecanoylphorbol-13-acetate-induced transcription, respectively, and involved in transrepression by E2. Tetradecanoylphorbol Acetate 112-148 C-C motif chemokine ligand 2 Homo sapiens 62-67 12753088-3 2003 Monocyte chemoattractant protein-1 (MCP-1 or CCL2) and regulated upon activation normal T cell expressed and secreted (RANTES) were found to protect mixed cultures of human neurons and astrocytes from tat or NMDA-induced apoptosis. N-Methylaspartate 208-212 C-C motif chemokine ligand 2 Homo sapiens 45-49 12732205-0 2003 High glucose accelerates MCP-1 production via p38 MAPK in vascular endothelial cells. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 25-30 12753088-8 2003 Co-treatment with MCP-1 inhibited tat and NMDA-induced increases in [Glu]e and NMDAR1, and also reduced the levels and number of neurons containing intracellular tat. N-Methylaspartate 42-46 C-C motif chemokine ligand 2 Homo sapiens 18-23 12753088-8 2003 Co-treatment with MCP-1 inhibited tat and NMDA-induced increases in [Glu]e and NMDAR1, and also reduced the levels and number of neurons containing intracellular tat. Glutamic Acid 69-72 C-C motif chemokine ligand 2 Homo sapiens 18-23 12753088-9 2003 These data indicate that MCP-1 may play a novel role as a protective agent against the toxic effects of glutamate and tat. Glutamic Acid 104-113 C-C motif chemokine ligand 2 Homo sapiens 25-30 12626661-3 2003 We investigated the effect of the angiotensin II type 1 (AT1) receptor antagonists irbesartan and losartan on MCP-1 production by freshly isolated human monocytes. Losartan 98-106 C-C motif chemokine ligand 2 Homo sapiens 110-115 12626661-4 2003 Irbesartan and losartan inhibited basal MCP-1 production in a dose-dependent manner. Irbesartan 0-10 C-C motif chemokine ligand 2 Homo sapiens 40-45 12626661-4 2003 Irbesartan and losartan inhibited basal MCP-1 production in a dose-dependent manner. Losartan 15-23 C-C motif chemokine ligand 2 Homo sapiens 40-45 12626661-6 2003 Irbesartan and losartan dose dependently blocked LDL-stimulated MCP-1. Irbesartan 0-10 C-C motif chemokine ligand 2 Homo sapiens 64-69 12626661-6 2003 Irbesartan and losartan dose dependently blocked LDL-stimulated MCP-1. Losartan 15-23 C-C motif chemokine ligand 2 Homo sapiens 64-69 12626661-8 2003 After noting homology between the AT1 receptor and the platelet-activating factor (PAF) receptor, we showed that irbesartan inhibited both [3H]PAF binding to human monocytes and carbamyl-PAF stimulation of MCP-1. Irbesartan 113-123 C-C motif chemokine ligand 2 Homo sapiens 206-211 12626661-8 2003 After noting homology between the AT1 receptor and the platelet-activating factor (PAF) receptor, we showed that irbesartan inhibited both [3H]PAF binding to human monocytes and carbamyl-PAF stimulation of MCP-1. 1-O-hexadecyl-2-N-methylcarbamylphosphatidylcholine 178-190 C-C motif chemokine ligand 2 Homo sapiens 206-211 12626661-9 2003 However, irbesartan affinity for the PAF receptor was 700 times less than PAF, suggesting that there may be another mechanism for irbesartan inhibition of PAF-stimulated MCP-1. Platelet Activating Factor 37-40 C-C motif chemokine ligand 2 Homo sapiens 170-175 12626661-9 2003 However, irbesartan affinity for the PAF receptor was 700 times less than PAF, suggesting that there may be another mechanism for irbesartan inhibition of PAF-stimulated MCP-1. Irbesartan 130-140 C-C motif chemokine ligand 2 Homo sapiens 170-175 12626661-10 2003 This is the first report showing that AT1 receptor antagonists inhibit basal as well as LDL- and PAF-stimulated MCP-1 production in freshly isolated human monocytes. Platelet Activating Factor 97-100 C-C motif chemokine ligand 2 Homo sapiens 112-117 12626663-10 2003 At the cellular level, AGI-1067 inhibited tumor necrosis factor-alpha-inducible expression of VCAM-1, MCP-1, and E-selectin in human aortic endothelial cells (IC50 values = 6, 10, and 25 microM, respectively). succinobucol 23-31 C-C motif chemokine ligand 2 Homo sapiens 102-107 12851645-3 2003 Mechanisms by which CCL2 may be acting include recruitment of regulatory and effector leukocytes; stimulation of histamine or leukotriene release from mast cells or basophils; induction of fibroblast production of transforming growth factor-beta (TGF-beta) and procollagen; and enhancement of Th2 polarization. Histamine 113-122 C-C motif chemokine ligand 2 Homo sapiens 20-24 12851645-3 2003 Mechanisms by which CCL2 may be acting include recruitment of regulatory and effector leukocytes; stimulation of histamine or leukotriene release from mast cells or basophils; induction of fibroblast production of transforming growth factor-beta (TGF-beta) and procollagen; and enhancement of Th2 polarization. Leukotrienes 126-137 C-C motif chemokine ligand 2 Homo sapiens 20-24 12826211-0 2003 Monocyte chemoattractant protein-1 levels in bronchoalveolar lavage fluid of lung-transplanted patients treated with tacrolimus as rescue treatment for refractory acute rejection. Tacrolimus 117-127 C-C motif chemokine ligand 2 Homo sapiens 0-34 12826211-5 2003 In contrast, monocyte chemoattractant protein-1 (MCP-1) levels showed a significant and sustained decrease in BAL-F during tacrolimus therapy. Tacrolimus 123-133 C-C motif chemokine ligand 2 Homo sapiens 13-47 12826211-5 2003 In contrast, monocyte chemoattractant protein-1 (MCP-1) levels showed a significant and sustained decrease in BAL-F during tacrolimus therapy. Tacrolimus 123-133 C-C motif chemokine ligand 2 Homo sapiens 49-54 12826211-7 2003 CONCLUSIONS: These findings suggest that the clinical and functional stabilization of patients observed after conversion to a tacrolimus based regimen, may be due, at least in part, to the induced down-regulation of MCP-1 production. Tacrolimus 126-136 C-C motif chemokine ligand 2 Homo sapiens 216-221 12732205-7 2003 SB203580 or FR167653, p38 MAPK specific inhibitors, completely suppressed MCP-1 expression. SB 203580 0-8 C-C motif chemokine ligand 2 Homo sapiens 74-79 12732205-7 2003 SB203580 or FR167653, p38 MAPK specific inhibitors, completely suppressed MCP-1 expression. FR 167653 12-20 C-C motif chemokine ligand 2 Homo sapiens 74-79 12732205-9 2003 These results indicate that hyperglycemia can accelerate MCP-1 production through the mechanism involving p38 MAPK, ROS-sensitive signaling pathway, in vascular endothelial cells. Reactive Oxygen Species 116-119 C-C motif chemokine ligand 2 Homo sapiens 57-62 12732205-4 2003 Chronic incubation with high glucose increased mRNA expression and production rate of MCP-1 in a time (1-7 days)- and concentration (10-35 mM)-dependent manner. Glucose 29-36 C-C motif chemokine ligand 2 Homo sapiens 86-91 12505873-9 2003 Modulation of the process of arteriogenesis is feasible in this large animal model via intra-arterial infusion of the Cys-Cys-chemokine MCP-1. cysteinylcysteine 118-125 C-C motif chemokine ligand 2 Homo sapiens 136-141 12697421-5 2003 The induced IL-8 and MCP-1 proteins were almost completely supporessed by U0126, a specific mitogen-activated protein kinase kinase (MEK) inhibitor, or by SB203580, a selective p38 inhibitor. U 0126 74-79 C-C motif chemokine ligand 2 Homo sapiens 21-26 12697421-5 2003 The induced IL-8 and MCP-1 proteins were almost completely supporessed by U0126, a specific mitogen-activated protein kinase kinase (MEK) inhibitor, or by SB203580, a selective p38 inhibitor. SB 203580 155-163 C-C motif chemokine ligand 2 Homo sapiens 21-26 12697421-7 2003 Induction of IL-8 and MCP-1 was abrogated by Ro318220, an inhibitor of PKC, as well as by genistein or herbimycin A, inhibitors of PTK. Ro 31-8220 45-53 C-C motif chemokine ligand 2 Homo sapiens 22-27 12697421-7 2003 Induction of IL-8 and MCP-1 was abrogated by Ro318220, an inhibitor of PKC, as well as by genistein or herbimycin A, inhibitors of PTK. Genistein 90-99 C-C motif chemokine ligand 2 Homo sapiens 22-27 12697421-7 2003 Induction of IL-8 and MCP-1 was abrogated by Ro318220, an inhibitor of PKC, as well as by genistein or herbimycin A, inhibitors of PTK. herbimycin 103-115 C-C motif chemokine ligand 2 Homo sapiens 22-27 12697421-8 2003 In addition, anti-inflammatory drugs dexamethasone (DEX) and cyclosporin A (CSA) both blocked activation of JNKS/SAPK and the cell-cell contact induced production of hRPE IL-8 and MCP-1, while activation of p38 and ERK was only inhibited by DEX, but not by CSA. Dexamethasone 37-50 C-C motif chemokine ligand 2 Homo sapiens 180-185 12697421-8 2003 In addition, anti-inflammatory drugs dexamethasone (DEX) and cyclosporin A (CSA) both blocked activation of JNKS/SAPK and the cell-cell contact induced production of hRPE IL-8 and MCP-1, while activation of p38 and ERK was only inhibited by DEX, but not by CSA. Dexamethasone 52-55 C-C motif chemokine ligand 2 Homo sapiens 180-185 12697421-8 2003 In addition, anti-inflammatory drugs dexamethasone (DEX) and cyclosporin A (CSA) both blocked activation of JNKS/SAPK and the cell-cell contact induced production of hRPE IL-8 and MCP-1, while activation of p38 and ERK was only inhibited by DEX, but not by CSA. Cyclosporine 61-74 C-C motif chemokine ligand 2 Homo sapiens 180-185 12697421-8 2003 In addition, anti-inflammatory drugs dexamethasone (DEX) and cyclosporin A (CSA) both blocked activation of JNKS/SAPK and the cell-cell contact induced production of hRPE IL-8 and MCP-1, while activation of p38 and ERK was only inhibited by DEX, but not by CSA. Cyclosporine 76-79 C-C motif chemokine ligand 2 Homo sapiens 180-185 12803507-5 2003 Urinary MCP-1 excretion levels in non-DN, DN, IgAN groups were 157.2 (52.8-378.5), 346.1 (147.0-1276.7), and 274.4 (162.2-994.5) ng/g creatinine, median (range), respectively. Creatinine 134-144 C-C motif chemokine ligand 2 Homo sapiens 8-13 12720581-5 2003 Both isoflavones also dose-dependently decreased monocyte chemoattractant protein-1 secretion induced by TNF-alpha in human umbilical vein endothelial cells. Isoflavones 5-16 C-C motif chemokine ligand 2 Homo sapiens 49-83 12667212-5 2003 The production of IL-8 and monocyte chemotactic protein 1 (MCP-1) was attenuated by 50% when these cells were preincubated with the p38 MAPK inhibitor, SB 203580. SB 203580 152-161 C-C motif chemokine ligand 2 Homo sapiens 27-57 12679798-4 2003 The levels of HSV-tk expression and GCV-sensitive tumoricidal activity of Ad-tk-MCP1 were comparable to those of rAd expressing HSV-tk alone. Ganciclovir 36-39 C-C motif chemokine ligand 2 Homo sapiens 80-84 12667212-5 2003 The production of IL-8 and monocyte chemotactic protein 1 (MCP-1) was attenuated by 50% when these cells were preincubated with the p38 MAPK inhibitor, SB 203580. SB 203580 152-161 C-C motif chemokine ligand 2 Homo sapiens 59-64 12667212-8 2003 Evaluation of IL-8 and MCP-1 RNA messages by reverse transcription-polymerase chain reaction (RT-PCR) revealed that the inhibitory effect of SB 203580 was associated with a reduction in this parameter. SB 203580 141-150 C-C motif chemokine ligand 2 Homo sapiens 23-28 12555204-6 2003 We found that QUIN induces astrocytes to produce large quantities of MCP-1 (CCL2) and lesser amounts of RANTES (CCL5) and IL-8 (CXCL8). Quinolinic Acid 14-18 C-C motif chemokine ligand 2 Homo sapiens 69-74 12663756-2 2003 Its protein product, pUS28, has been shown to bind several human CC chemokines, including RANTES, MCP-1, and MIP-1 alpha, and the CX(3)C chemokine fractalkine with high affinity. pus28 21-26 C-C motif chemokine ligand 2 Homo sapiens 98-103 12554737-4 2003 The affinity of vCCL4 for the CCR2 receptor was 79 nm as determined in competition binding against radioactively labeled CCL2. vccl4 16-21 C-C motif chemokine ligand 2 Homo sapiens 121-125 12555204-6 2003 We found that QUIN induces astrocytes to produce large quantities of MCP-1 (CCL2) and lesser amounts of RANTES (CCL5) and IL-8 (CXCL8). Quinolinic Acid 14-18 C-C motif chemokine ligand 2 Homo sapiens 76-80 12647268-8 2003 Preincubation with 4-ethyl-2-hydroxyimino-5-nitro-3-hexenamide, a NO donor, abrogated increased expression of MCP-1 mRNA and high NF-kappaB activity induced by PLA2-treated LDL and by LDL isolated from diabetic patients. FK 409 19-62 C-C motif chemokine ligand 2 Homo sapiens 110-115 12783131-0 2003 Vitamin C protects against lysophosphatidylcholine-induced expression of monocyte chemoattractant protein-1 in cultured human umbilical vein endothelial cells. Ascorbic Acid 0-9 C-C motif chemokine ligand 2 Homo sapiens 73-107 12783131-0 2003 Vitamin C protects against lysophosphatidylcholine-induced expression of monocyte chemoattractant protein-1 in cultured human umbilical vein endothelial cells. Lysophosphatidylcholines 27-50 C-C motif chemokine ligand 2 Homo sapiens 73-107 12783131-3 2003 The purpose of this study was to determine whether pretreatment with vitamin C could protect against oxidized-LDL-induced expression of MCP-1 in cultured human umbilical vein endothelial cells (HUVECs). Ascorbic Acid 69-78 C-C motif chemokine ligand 2 Homo sapiens 136-141 12783131-5 2003 Lysophosphatidylcholine (lysoPC), an oxidized component of LDL, was designated as the stimulator for MCP-1 synthesis from cultured HUVECs. Lysophosphatidylcholines 0-23 C-C motif chemokine ligand 2 Homo sapiens 101-106 12783131-9 2003 Compared with samples treated with lysoPC alone, pretreatment with vitamin C in concentrations of 50, 100, 150, and 200 microM, reduced levels of MCP-1 in the culture medium by 44%, 51%, 60%, and 67%, respectively, while levels of MCP-1 mRNA decreased by 15%, 18%, 80%, and 82%, respectively. Ascorbic Acid 67-76 C-C motif chemokine ligand 2 Homo sapiens 146-151 12783131-9 2003 Compared with samples treated with lysoPC alone, pretreatment with vitamin C in concentrations of 50, 100, 150, and 200 microM, reduced levels of MCP-1 in the culture medium by 44%, 51%, 60%, and 67%, respectively, while levels of MCP-1 mRNA decreased by 15%, 18%, 80%, and 82%, respectively. Ascorbic Acid 67-76 C-C motif chemokine ligand 2 Homo sapiens 231-236 12783131-10 2003 CONCLUSIONS: Our findings imply that pretreatment with vitamin C can suppress lysoPC-induced expression and secretion of MCP-1 in cultured HUVECs. Ascorbic Acid 55-64 C-C motif chemokine ligand 2 Homo sapiens 121-126 12640339-11 2003 In addition, the percentage increment of MCP-1 was higher in patients treated with gemfibrozil than in patients who received bezafibrate. Gemfibrozil 83-94 C-C motif chemokine ligand 2 Homo sapiens 41-46 12640339-11 2003 In addition, the percentage increment of MCP-1 was higher in patients treated with gemfibrozil than in patients who received bezafibrate. Bezafibrate 125-136 C-C motif chemokine ligand 2 Homo sapiens 41-46 12640339-13 2003 This finding was associated with increased HDL-C. Fibrates, especially gemfibrozil, increased MCP-1 concentrations. Gemfibrozil 71-82 C-C motif chemokine ligand 2 Homo sapiens 94-99 12527037-8 2003 The secretion of MCP-1 and IL-6 was markedly stimulated by TC. Taurocholic Acid 59-61 C-C motif chemokine ligand 2 Homo sapiens 17-22 12578870-3 2003 METHODS AND RESULTS: MCP-1 was measured from frozen plasma specimens in 279 healthy volunteers and 2270 patients with acute coronary syndromes enrolled in the Oral Glycoprotein IIb/IIIa Inhibition with Orbofiban in Patients with Unstable Coronary Syndromes (OPUS-TIMI) 16 trial. orbofiban 202-211 C-C motif chemokine ligand 2 Homo sapiens 21-26 12595852-0 2003 Intravenous prostaglandin E1 reduces monocyte chemoattractant protein-1 levels in peripheral arterial obstructive disease. Alprostadil 12-28 C-C motif chemokine ligand 2 Homo sapiens 37-71 12548076-4 2003 In the in vitro experiment, propagermanium concentration-dependently suppressed the MCP-1-induced migration of THP-1 cells. propagermanium 28-42 C-C motif chemokine ligand 2 Homo sapiens 84-89 12629330-0 2003 Dual response to Fas ligation in human endothelial cells: apoptosis and induction of chemokines, interleukin-8 and monocyte chemoattractant protein-1. ammonium ferrous sulfate 17-20 C-C motif chemokine ligand 2 Homo sapiens 115-149 12629330-4 2003 We also investigated whether an inhibitor of caspase-8 (Z-IETD-FMK) does modulate IL-8 and MCP-1 secretion. benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone 56-66 C-C motif chemokine ligand 2 Homo sapiens 91-96 12629330-9 2003 Fas-neutralizing agent (Fas-Fc) suppressed the Fas-mediated secretions of IL-8 and MCP-1 (P < 0.01) both as well as the Fas-mediated apoptosis. ammonium ferrous sulfate 0-3 C-C motif chemokine ligand 2 Homo sapiens 83-88 12629330-9 2003 Fas-neutralizing agent (Fas-Fc) suppressed the Fas-mediated secretions of IL-8 and MCP-1 (P < 0.01) both as well as the Fas-mediated apoptosis. ammonium ferrous sulfate 24-27 C-C motif chemokine ligand 2 Homo sapiens 83-88 12629330-9 2003 Fas-neutralizing agent (Fas-Fc) suppressed the Fas-mediated secretions of IL-8 and MCP-1 (P < 0.01) both as well as the Fas-mediated apoptosis. ammonium ferrous sulfate 24-27 C-C motif chemokine ligand 2 Homo sapiens 83-88 12629330-9 2003 Fas-neutralizing agent (Fas-Fc) suppressed the Fas-mediated secretions of IL-8 and MCP-1 (P < 0.01) both as well as the Fas-mediated apoptosis. ammonium ferrous sulfate 24-27 C-C motif chemokine ligand 2 Homo sapiens 83-88 12629330-10 2003 On the other hand, whereas Z-IETD-FMK suppressed apoptosis, the inhibitor enhanced the Fas-mediated secretions of both IL-8 and MCP-1 beyond the value of the Fas stimulation alone (P < 0.01), suggesting an enhanced signalling for the chemokine expression. ammonium ferrous sulfate 87-90 C-C motif chemokine ligand 2 Homo sapiens 128-133 12595852-6 2003 PGE1 administration for 7 days resulted in a significant decrease in the MCP-1 level, from 263.8 +/- 52.8 to 196.1 +/- 25.5 pg/mL (P =.02), whereas levels of IL-6, hs-CRP, and ET-1 and the activity of vWF were not affected. Alprostadil 0-4 C-C motif chemokine ligand 2 Homo sapiens 73-78 12595852-8 2003 Parenteral administration of PGE1 appeared to decrease circulating MCP-1 levels, which might lead to the suppression of the development of atherosclerotic lesions in patients with PAOD. Alprostadil 29-33 C-C motif chemokine ligand 2 Homo sapiens 67-72 12627328-0 2003 Pigment epithelium-derived factor prevents advanced glycation end products-induced monocyte chemoattractant protein-1 production in microvascular endothelial cells by suppressing intracellular reactive oxygen species generation. Reactive Oxygen Species 193-216 C-C motif chemokine ligand 2 Homo sapiens 83-117 12627328-11 2003 An anti-oxidant, N-acetylcysteine, or pigment epithelium-derived factor completely prevented the AGE-induced up-regulation of MCP-1 mRNA contents as well as protein production in microvascular endothelial cells. Acetylcysteine 17-33 C-C motif chemokine ligand 2 Homo sapiens 126-131 12671447-7 2003 Macrophage-inflammatory protein-1-alpha and monocyte chemotactic protein-1 levels also are inversely related to oxygen saturation, suggesting that severity of RSV disease may be linked to chemokine release. Oxygen 112-118 C-C motif chemokine ligand 2 Homo sapiens 44-74 15206714-6 2003 We found that QUIN induces astrocytes to produce large quantities of MCP-1 (CCL2), and lesser amounts of RANTES (CCL5), IL-8 (CXCL8). Quinolinic Acid 14-18 C-C motif chemokine ligand 2 Homo sapiens 69-74 12471621-3 2003 We have, therefore, extended the observation by testing the effects of doxorubicin on expression of the chemokine family and provide here definitive evidence that doxorubicin induces IL-8 and MCP-1, one of the CC chemokines, at least in 2 human SCLC cells, H69 and SBC-1. Doxorubicin 71-82 C-C motif chemokine ligand 2 Homo sapiens 192-197 12471621-3 2003 We have, therefore, extended the observation by testing the effects of doxorubicin on expression of the chemokine family and provide here definitive evidence that doxorubicin induces IL-8 and MCP-1, one of the CC chemokines, at least in 2 human SCLC cells, H69 and SBC-1. Doxorubicin 163-174 C-C motif chemokine ligand 2 Homo sapiens 192-197 12471621-6 2003 MCP-1 antigen levels increased approximately 100-fold in doxorubicin-treated H69 cells. Doxorubicin 57-68 C-C motif chemokine ligand 2 Homo sapiens 0-5 12471621-7 2003 RT-PCR using specific primers for MCP-1 suggested that doxorubicin also induced MCP-1 expression in SBC-1 and SBC-3 SCLC cells. Doxorubicin 55-66 C-C motif chemokine ligand 2 Homo sapiens 34-39 12471621-7 2003 RT-PCR using specific primers for MCP-1 suggested that doxorubicin also induced MCP-1 expression in SBC-1 and SBC-3 SCLC cells. Doxorubicin 55-66 C-C motif chemokine ligand 2 Homo sapiens 80-85 12471621-10 2003 IL-8 and MCP-1 are major chemoattractants for neutrophils and monocytes/macrophages, respectively; therefore, extensive induction of IL-8 and MCP-1 may provoke the interaction between inflammatory/immune cells and tumor cells under doxorubicin stimulation and influence many aspects of tumor cell biology. Doxorubicin 232-243 C-C motif chemokine ligand 2 Homo sapiens 9-14 12471621-10 2003 IL-8 and MCP-1 are major chemoattractants for neutrophils and monocytes/macrophages, respectively; therefore, extensive induction of IL-8 and MCP-1 may provoke the interaction between inflammatory/immune cells and tumor cells under doxorubicin stimulation and influence many aspects of tumor cell biology. Doxorubicin 232-243 C-C motif chemokine ligand 2 Homo sapiens 142-147 15206714-6 2003 We found that QUIN induces astrocytes to produce large quantities of MCP-1 (CCL2), and lesser amounts of RANTES (CCL5), IL-8 (CXCL8). Quinolinic Acid 14-18 C-C motif chemokine ligand 2 Homo sapiens 76-80 12473373-4 2003 In the present study, we investigated whether the synthetic KOR ligand trans-3,4-dichloro-N-methyl-N[2-(1-pyrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate (U50,488) would down-regulate MCP-1 production in primary human astrocytes stimulated by Tat. trans-3,4-dichloro-n-methyl-n[2-(1-pyrolidinyl)cyclohexyl]benzeneacetamide methanesulfonate 71-162 C-C motif chemokine ligand 2 Homo sapiens 193-198 12388243-3 2003 Antioxidants, such as pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC), significantly inhibited IL-4-induced MCP-1 mRNA expression. pyrrolidine dithiocarbamic acid 22-49 C-C motif chemokine ligand 2 Homo sapiens 122-127 12388243-3 2003 Antioxidants, such as pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC), significantly inhibited IL-4-induced MCP-1 mRNA expression. pyrrolidine dithiocarbamic acid 51-55 C-C motif chemokine ligand 2 Homo sapiens 122-127 12388243-3 2003 Antioxidants, such as pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC), significantly inhibited IL-4-induced MCP-1 mRNA expression. Acetylcysteine 61-77 C-C motif chemokine ligand 2 Homo sapiens 122-127 12388243-3 2003 Antioxidants, such as pyrrolidine dithiocarbamate (PDTC) and N-acetylcysteine (NAC), significantly inhibited IL-4-induced MCP-1 mRNA expression. Acetylcysteine 79-82 C-C motif chemokine ligand 2 Homo sapiens 122-127 12456364-12 2003 The NF-kappaB inhibitor, Bay-11, inhibited expression of MCP-1. bay-11 25-31 C-C motif chemokine ligand 2 Homo sapiens 57-62 15018304-2 2003 We have very recently found that nifedipine, one of the most popularly used dihydropyridine-based calcium antagonists, prevented EC monocyte chemoattractant protein-1 production elicited by tumor necrosis factor-alpha (TNF-alpha through its antioxidative properties. Nifedipine 33-43 C-C motif chemokine ligand 2 Homo sapiens 132-166 15018304-2 2003 We have very recently found that nifedipine, one of the most popularly used dihydropyridine-based calcium antagonists, prevented EC monocyte chemoattractant protein-1 production elicited by tumor necrosis factor-alpha (TNF-alpha through its antioxidative properties. 1,4-dihydropyridine 76-91 C-C motif chemokine ligand 2 Homo sapiens 132-166 15018304-2 2003 We have very recently found that nifedipine, one of the most popularly used dihydropyridine-based calcium antagonists, prevented EC monocyte chemoattractant protein-1 production elicited by tumor necrosis factor-alpha (TNF-alpha through its antioxidative properties. Calcium 98-105 C-C motif chemokine ligand 2 Homo sapiens 132-166 15018305-0 2003 Nifedipine inhibits tumor necrosis factor-alpha-induced monocyte chemoattractant protein-1 overexpression by blocking NADPH oxidase-mediated reactive oxygen species generation. Nifedipine 0-10 C-C motif chemokine ligand 2 Homo sapiens 56-90 15018305-0 2003 Nifedipine inhibits tumor necrosis factor-alpha-induced monocyte chemoattractant protein-1 overexpression by blocking NADPH oxidase-mediated reactive oxygen species generation. Reactive Oxygen Species 141-164 C-C motif chemokine ligand 2 Homo sapiens 56-90 15018305-4 2003 In this study, we investigated whether nifedipine, one of the most popular DHPs, could inhibit tumor necrosis factor-alpha (TNF-alpha)-induced reactive oxygen species (ROS) generation and subsequent monocyte chemoattractant protein-1 (MCP-1) expression in human umbilical vein endothelial cells (HUVEC). Nifedipine 39-49 C-C motif chemokine ligand 2 Homo sapiens 199-233 15018305-4 2003 In this study, we investigated whether nifedipine, one of the most popular DHPs, could inhibit tumor necrosis factor-alpha (TNF-alpha)-induced reactive oxygen species (ROS) generation and subsequent monocyte chemoattractant protein-1 (MCP-1) expression in human umbilical vein endothelial cells (HUVEC). Nifedipine 39-49 C-C motif chemokine ligand 2 Homo sapiens 235-240 15018305-7 2003 Furthermore, nifedipine was found to significantly inhibit upregulation of MCP-1 messenger RNA levels in TNF-alpha-exposed HUVEC. Nifedipine 13-23 C-C motif chemokine ligand 2 Homo sapiens 75-80 15018305-8 2003 The results demonstrate that nifedipine could inhibit TNF-alpha-induced MCP-1 overexpression in HUVEC by suppressing NADPH oxidase-mediated ROS generation. Nifedipine 29-39 C-C motif chemokine ligand 2 Homo sapiens 72-77 15018305-8 2003 The results demonstrate that nifedipine could inhibit TNF-alpha-induced MCP-1 overexpression in HUVEC by suppressing NADPH oxidase-mediated ROS generation. Reactive Oxygen Species 140-143 C-C motif chemokine ligand 2 Homo sapiens 72-77 12499080-2 2003 MEM significantly inhibited PMA-induced secretions of IL-8 and MCP-1 proteins in a dose-dependent manner. Tetradecanoylphorbol Acetate 28-31 C-C motif chemokine ligand 2 Homo sapiens 63-68 12499080-4 2003 In addition, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, one of major constituents isolated from MEM, inhibited PMA-induced secretions of IL-8 and MCP-1 proteins by its suppression of IL-8 and MCP-1 genes. beta-penta-O-galloyl-glucose 13-53 C-C motif chemokine ligand 2 Homo sapiens 145-150 12499080-4 2003 In addition, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, one of major constituents isolated from MEM, inhibited PMA-induced secretions of IL-8 and MCP-1 proteins by its suppression of IL-8 and MCP-1 genes. beta-penta-O-galloyl-glucose 13-53 C-C motif chemokine ligand 2 Homo sapiens 191-196 12499080-4 2003 In addition, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, one of major constituents isolated from MEM, inhibited PMA-induced secretions of IL-8 and MCP-1 proteins by its suppression of IL-8 and MCP-1 genes. Tetradecanoylphorbol Acetate 110-113 C-C motif chemokine ligand 2 Homo sapiens 145-150 12499080-4 2003 In addition, 1,2,3,4,6-penta-O-galloyl-beta-D-glucose, one of major constituents isolated from MEM, inhibited PMA-induced secretions of IL-8 and MCP-1 proteins by its suppression of IL-8 and MCP-1 genes. Tetradecanoylphorbol Acetate 110-113 C-C motif chemokine ligand 2 Homo sapiens 191-196 12505750-5 2003 The median urinary excretion level of MCP-1 in patients with macroalbuminuria (394.4 ng/g creatinine) was significantly elevated compared to the levels in patients with normoalbuminuria and microalbuminuria (159.6 and 193.9 ng/g creatinine, respectively). Creatinine 90-100 C-C motif chemokine ligand 2 Homo sapiens 38-43 12505750-5 2003 The median urinary excretion level of MCP-1 in patients with macroalbuminuria (394.4 ng/g creatinine) was significantly elevated compared to the levels in patients with normoalbuminuria and microalbuminuria (159.6 and 193.9 ng/g creatinine, respectively). Creatinine 229-239 C-C motif chemokine ligand 2 Homo sapiens 38-43 12427122-6 2002 RESULTS: Endocytosis of LCs induced the release of interleukins (IL) IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1); however, there was considerable variability among the six different LCs. lcs 24-27 C-C motif chemokine ligand 2 Homo sapiens 84-118 12877820-7 2003 At all the concentrations tested, MOM was more effective than DEX in inhibiting ICAM-1 expression and MCP-1 release (p<0.05, each comparison), whereas no potency advantage for MOM was detected in DNA synthesis, cell proliferation, HCAM expression and in eotaxin, IL-6 and TGF-beta release (p>0.05, each comparisons). Mometasone Furoate 34-37 C-C motif chemokine ligand 2 Homo sapiens 102-107 12877820-7 2003 At all the concentrations tested, MOM was more effective than DEX in inhibiting ICAM-1 expression and MCP-1 release (p<0.05, each comparison), whereas no potency advantage for MOM was detected in DNA synthesis, cell proliferation, HCAM expression and in eotaxin, IL-6 and TGF-beta release (p>0.05, each comparisons). Dexamethasone 62-65 C-C motif chemokine ligand 2 Homo sapiens 102-107 12359346-8 2002 The cytokine arrays showed that expression of several cytokines, particularly monocyte chemoattractant protein-1 (MCP-1), was profoundly reduced in vitamin E supplementation individuals. Vitamin E 148-157 C-C motif chemokine ligand 2 Homo sapiens 78-112 12359346-8 2002 The cytokine arrays showed that expression of several cytokines, particularly monocyte chemoattractant protein-1 (MCP-1), was profoundly reduced in vitamin E supplementation individuals. Vitamin E 148-157 C-C motif chemokine ligand 2 Homo sapiens 114-119 12359346-9 2002 Moreover, addition of vitamin E to several cultured cells significantly down-regulated the expression of MCP-1. Vitamin E 22-31 C-C motif chemokine ligand 2 Homo sapiens 105-110 12359346-10 2002 Our results suggested that MCP-1 may be one of the most important targets of antioxidant vitamin E. Vitamin E 89-98 C-C motif chemokine ligand 2 Homo sapiens 27-32 12359346-11 2002 To the best of our knowledge, this is the first report describing the down-regulation of MCP-1 in vitamin E supplementation in vivo. Vitamin E 98-107 C-C motif chemokine ligand 2 Homo sapiens 89-94 12460032-3 2002 METHODS: In the 5" flanking region of the MCP-1 gene, a guanine (G)/adenine (A) transition identified at position -2518 upstream from the transcription site was reported to be associated with circulating levels. Guanine 56-63 C-C motif chemokine ligand 2 Homo sapiens 42-47 12460032-3 2002 METHODS: In the 5" flanking region of the MCP-1 gene, a guanine (G)/adenine (A) transition identified at position -2518 upstream from the transcription site was reported to be associated with circulating levels. Adenine 68-75 C-C motif chemokine ligand 2 Homo sapiens 42-47 12446609-9 2002 In contrast, exogenous corticosterone abolished the effects of ketorolac on IL-1beta-induced COX-2 and monocyte chemoattractant protein-1 gene expression in the cerebral endothelium. Corticosterone 23-37 C-C motif chemokine ligand 2 Homo sapiens 103-137 12446609-9 2002 In contrast, exogenous corticosterone abolished the effects of ketorolac on IL-1beta-induced COX-2 and monocyte chemoattractant protein-1 gene expression in the cerebral endothelium. Ketorolac 63-72 C-C motif chemokine ligand 2 Homo sapiens 103-137 12427122-6 2002 RESULTS: Endocytosis of LCs induced the release of interleukins (IL) IL-6, IL-8 and monocyte chemoattractant protein-1 (MCP-1); however, there was considerable variability among the six different LCs. lcs 24-27 C-C motif chemokine ligand 2 Homo sapiens 120-125 12393099-6 2002 MCP-1 also induced secretion of matrix metalloproteinase (MMP)-2 which along with ERK activation was inhibited by PD098059. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 114-122 C-C motif chemokine ligand 2 Homo sapiens 0-5 12399621-0 2002 Exogenous nitric oxide inhibits tumor necrosis factor-alpha- or interleukin-1-beta-induced monocyte chemoattractant protein-1 expression in human mesangial cells. Nitric Oxide 10-22 C-C motif chemokine ligand 2 Homo sapiens 91-125 12399621-2 2002 Monocyte chemoattractant protein-1 (MCP-1) plays an important role in glomerulonephritis and nitric oxide (NO) exerts a variety of renal pathophysiological effects. Nitric Oxide 93-105 C-C motif chemokine ligand 2 Homo sapiens 36-41 12399621-9 2002 Nitroprusside inhibited the MCP-1 mRNA expression as well. Nitroprusside 0-13 C-C motif chemokine ligand 2 Homo sapiens 28-33 12399621-12 2002 These results suggest that exogenous NO inhibits MCP-1 expression via suppression of NF-kappaB by reducing the degradation of IkappaB-alpha and through a cGMP-independent pathway. Cyclic GMP 154-158 C-C motif chemokine ligand 2 Homo sapiens 49-54 12399623-0 2002 Differential expression of MCP-1 and its receptor CCR2 in glucose primed human mesangial cells. Glucose 58-65 C-C motif chemokine ligand 2 Homo sapiens 27-32 12399623-3 2002 In the present study, we examined whether the ambient glucose concentration alters the expression of MCP-1 and its receptor CCR2 in primary human mesangial cells (HMC). Glucose 54-61 C-C motif chemokine ligand 2 Homo sapiens 101-106 12399623-7 2002 RESULTS: Exposure of HMC to 30 mM D-glucose led to a 30% increase in MCP-1 mRNA expression as compared to 5 mM D-glucose and osmotic controls while there was no difference in MCP-1 protein production. Glucose 34-43 C-C motif chemokine ligand 2 Homo sapiens 69-74 12399623-9 2002 5 mM D-glucose primed HMC showed a dose-dependent migration towards MCP-1 that was dose-dependently inhibited by pertussis toxin, the broad-spectrum chemokine antagonist vMIP-II as well as the CCR2 receptor antagonist (1-8del)MCP-1--demonstrating functional activity of MCP-1 receptor expression in primary HMC. Glucose 5-14 C-C motif chemokine ligand 2 Homo sapiens 68-73 12399623-9 2002 5 mM D-glucose primed HMC showed a dose-dependent migration towards MCP-1 that was dose-dependently inhibited by pertussis toxin, the broad-spectrum chemokine antagonist vMIP-II as well as the CCR2 receptor antagonist (1-8del)MCP-1--demonstrating functional activity of MCP-1 receptor expression in primary HMC. Glucose 5-14 C-C motif chemokine ligand 2 Homo sapiens 226-231 12529758-3 2002 Exposure to homocysteine under flow resulted in altered expression of 8 genes, the alterations of 3 of which were further confirmed by RT-PCR analysis: upregulation of MCP-1 and of profilin-I, and downregulation of alpha-catenin. Homocysteine 12-24 C-C motif chemokine ligand 2 Homo sapiens 168-173 12215436-4 2002 PGE(2) (50 nm) attenuated LPS-induced mRNA and protein expression of chemokines including monocyte chemoattractant protein-1, interleukin-8, macrophage inflammatory protein-1alpha and -1beta, and interferon-inducible protein-10. Prostaglandins E 0-3 C-C motif chemokine ligand 2 Homo sapiens 90-124 12447609-3 2002 In infected human macrophages, treatment with MCP-1 or MIP-1 alpha significantly enhanced nitric oxide production and leishmanicidal ability, compared with untreated cells, to the same levels induced by interferon-gamma. Nitric Oxide 90-102 C-C motif chemokine ligand 2 Homo sapiens 46-51 12447609-5 2002 These data suggest that MCP-1 and MIP-1 alpha mediate macrophage activation for nitric oxide release and subsequent parasite clearance, and thus may play a role in the containment of Leishmania infection. Nitric Oxide 80-92 C-C motif chemokine ligand 2 Homo sapiens 24-29 12368213-7 2002 GS-NO-treated psoriatic skin showed reduction of IP-10, RANTES, and MCP-1, but not interleukin-8 expression by keratinocytes. gs-no 0-5 C-C motif chemokine ligand 2 Homo sapiens 68-73 12271471-2 2002 Here we show that cultured human fetal astrocytes express CCR2 at the mRNA and protein levels, and display chemotaxis and calcium flux in response to MCP-1. Calcium 122-129 C-C motif chemokine ligand 2 Homo sapiens 150-155 12234797-3 2002 MCP-1 induced concentration-dependent VSMC proliferation as measured by bromodeoxyuridine (BrdU) uptake. Bromodeoxyuridine 72-89 C-C motif chemokine ligand 2 Homo sapiens 0-5 12234797-3 2002 MCP-1 induced concentration-dependent VSMC proliferation as measured by bromodeoxyuridine (BrdU) uptake. Bromodeoxyuridine 91-95 C-C motif chemokine ligand 2 Homo sapiens 0-5 12411463-6 2002 Pioglitazone did not reduce local expression of MCP-1 but markedly attenuated increased expression of the MCP-1 receptor C-C chemokine receptor 2 (CCR2) in lesional and circulating monocytes. Pioglitazone 0-12 C-C motif chemokine ligand 2 Homo sapiens 106-111 12397680-1 2002 Angiotensin II(AngII) activates NADH/NAPDH oxidase activity and stimulates reactive oxygen species(ROS) production, which induces many proinflammatory genes such as vascular cell adhesion molecule-1(VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and monocyte chemoattractant protein-1(MCP-1) mainly via AngII type I receptor(AT1). Reactive Oxygen Species 99-102 C-C motif chemokine ligand 2 Homo sapiens 256-290 12231210-4 2002 SP had a significant effect in that it decreased RA synovial tissue explant secretion of IL-8 (22%), GROalpha (55%), and monocyte chemotactic protein-1 (MCP-1) (42%) (P < 0.05). Sulfapyridine 0-2 C-C motif chemokine ligand 2 Homo sapiens 121-151 12231210-4 2002 SP had a significant effect in that it decreased RA synovial tissue explant secretion of IL-8 (22%), GROalpha (55%), and monocyte chemotactic protein-1 (MCP-1) (42%) (P < 0.05). Sulfapyridine 0-2 C-C motif chemokine ligand 2 Homo sapiens 153-158 12231210-8 2002 These data suggest that SASP may function to reduce inflammation in RA through the effects of its metabolite SP to reduce the secretion of the inflammatory chemokines IL-8, GROalpha, and MCP-1. Sulfapyridine 26-28 C-C motif chemokine ligand 2 Homo sapiens 187-192 12244182-8 2002 Pyrrolidine dithiocarbamate, an antioxidant, inhibited the activation of NF-kappaB and significantly diminished the MAC-induced chemotaxis, concurrently lowering the levels of monocyte chemotactic protein-1 and MIP-1beta. pyrrolidine dithiocarbamic acid 0-27 C-C motif chemokine ligand 2 Homo sapiens 176-206 12296854-7 2002 Moreover, blocking the activation of NF-kappaB by MG-132 or antisense p50 oligonucleotide transfection resulted in down-regulated expression of chemokines such as CXCL1, CXCL8, and CCL2 in BFT-stimulated HT-29 cells. benzyloxycarbonylleucyl-leucyl-leucine aldehyde 50-56 C-C motif chemokine ligand 2 Homo sapiens 181-185 12296854-7 2002 Moreover, blocking the activation of NF-kappaB by MG-132 or antisense p50 oligonucleotide transfection resulted in down-regulated expression of chemokines such as CXCL1, CXCL8, and CCL2 in BFT-stimulated HT-29 cells. Oligonucleotides 74-89 C-C motif chemokine ligand 2 Homo sapiens 181-185 12351486-7 2002 Plasma MCP-1 was positively correlated with HbA(1c), FPLPs, MDA, and AER, whereas plasma MCP-1 showed an inverse correlation with vitamin E. Vitamin E 130-139 C-C motif chemokine ligand 2 Homo sapiens 89-94 12351486-8 2002 Interestingly, both MCP-1 and AER decreased significantly after vitamin E treatment, despite no changes in HbA(1c) values. Vitamin E 64-73 C-C motif chemokine ligand 2 Homo sapiens 20-25 12351486-10 2002 Long-term treatment of high-dose vitamin E significantly decreased MCP-1, thus providing a rationale basis for evaluating vitamin E supplementation as therapy adjuvant to conventional insulin treatment in type 1 diabetic patients in whom an acceptable glycemic control is difficult to achieve despite appropriate insulin treatment. Vitamin E 33-42 C-C motif chemokine ligand 2 Homo sapiens 67-72 12383538-6 2002 Monocyte chemoattractant protein-1 and interleukin-8 production was decreased by the antioxidant vitamin E in human umbilical vein endothelial cells treated with preeclamptic plasma, suggesting that the production of these cytokines may be regulated by signaling mechanisms sensitive to oxidative stress. Vitamin E 97-106 C-C motif chemokine ligand 2 Homo sapiens 0-34 12397680-1 2002 Angiotensin II(AngII) activates NADH/NAPDH oxidase activity and stimulates reactive oxygen species(ROS) production, which induces many proinflammatory genes such as vascular cell adhesion molecule-1(VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and monocyte chemoattractant protein-1(MCP-1) mainly via AngII type I receptor(AT1). Reactive Oxygen Species 99-102 C-C motif chemokine ligand 2 Homo sapiens 291-296 12218154-9 2002 These results show that the inhibition of IL-1alpha-mediated MCP-1 production by alprazolam is mainly due to inhibition of c-Rel/p65 and c-Rel/p50 binding to the MCP-1 promoter region, since alprazolam did not affect the IL-1alpha-mediated activation of NF-kappaB (p50/p65) or AP-1 (c-Jun/c-Fos) binding to the IL-8 promoter region. Alprazolam 191-201 C-C motif chemokine ligand 2 Homo sapiens 162-167 12218154-4 2002 We found that alprazolam inhibited IL-1alpha-elicited MCP-1 production within a range of 0.1-3 micro M. In contrast, it did not inhibit IL-1alpha-induced IL-8 production. Alprazolam 14-24 C-C motif chemokine ligand 2 Homo sapiens 54-59 12204776-0 2002 17Beta-estradiol inhibits the adhesion of leukocytes in TNF-alpha stimulated human endothelial cells by blocking IL-8 and MCP-1 secretion, but not its transcription. Estradiol 0-16 C-C motif chemokine ligand 2 Homo sapiens 122-127 12218154-0 2002 Suppression of monocyte chemoattractant protein 1, but not IL-8, by alprazolam: effect of alprazolam on c-Rel/p65 and c-Rel/p50 binding to the monocyte chemoattractant protein 1 promoter region. Alprazolam 68-78 C-C motif chemokine ligand 2 Homo sapiens 15-49 12200757-3 2002 Oxidized (oxLDL) or goLDL enhanced MCP-1 mRNA expression in HUVEC, and preincubation with NOR3, a NO donor, abrogated such stimulation. FK 409 90-94 C-C motif chemokine ligand 2 Homo sapiens 35-40 12411099-7 2002 It was found that steroid and CTX intermittent intravenous pulse therapy reduced the expression of CD68, MCP-1, and MIP-1alpha, but had no effect on MIP-1beta in glomeruli with cellular crescents of patients with LN-CGN. Steroids 18-25 C-C motif chemokine ligand 2 Homo sapiens 105-110 12218154-6 2002 Alprazolam prevented NF-kappaB from binding to the MCP-1 promoter region (the A2 and A1 oligonucleotide probes), but binding of NF-kappaB to IL-8/NF-kappaB was not inhibited. Alprazolam 0-10 C-C motif chemokine ligand 2 Homo sapiens 51-56 12218154-9 2002 These results show that the inhibition of IL-1alpha-mediated MCP-1 production by alprazolam is mainly due to inhibition of c-Rel/p65 and c-Rel/p50 binding to the MCP-1 promoter region, since alprazolam did not affect the IL-1alpha-mediated activation of NF-kappaB (p50/p65) or AP-1 (c-Jun/c-Fos) binding to the IL-8 promoter region. Alprazolam 81-91 C-C motif chemokine ligand 2 Homo sapiens 61-66 12218154-9 2002 These results show that the inhibition of IL-1alpha-mediated MCP-1 production by alprazolam is mainly due to inhibition of c-Rel/p65 and c-Rel/p50 binding to the MCP-1 promoter region, since alprazolam did not affect the IL-1alpha-mediated activation of NF-kappaB (p50/p65) or AP-1 (c-Jun/c-Fos) binding to the IL-8 promoter region. Alprazolam 81-91 C-C motif chemokine ligand 2 Homo sapiens 162-167 12218154-9 2002 These results show that the inhibition of IL-1alpha-mediated MCP-1 production by alprazolam is mainly due to inhibition of c-Rel/p65 and c-Rel/p50 binding to the MCP-1 promoter region, since alprazolam did not affect the IL-1alpha-mediated activation of NF-kappaB (p50/p65) or AP-1 (c-Jun/c-Fos) binding to the IL-8 promoter region. Alprazolam 191-201 C-C motif chemokine ligand 2 Homo sapiens 61-66 12200757-0 2002 Glycoxidized low-density lipoprotein enhances monocyte chemoattractant protein-1 mRNA expression in human umbilical vein endothelial cells: relation to lysophosphatidylcholine contents and inhibition by nitric oxide donor. Lysophosphatidylcholines 152-175 C-C motif chemokine ligand 2 Homo sapiens 46-80 12297109-5 2002 Using reverse transcriptase-polymerase chain reaction (RT-PCR), immunoprecipitation and western blot analysis, we report that the early signalling events triggered by the hIL-17 involved tyrosyl phosphorylation of proteins and increased the levels of IL-6, IL-8 and MCP-1 in a dose-dependent manner. cyclo(tyrosyl-tyrosyl) 187-194 C-C motif chemokine ligand 2 Homo sapiens 266-271 12117737-0 2002 Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients. Simvastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 78-112 12123781-0 2002 Female gender, menstrual cycle and estradiol affect plasma levels of monocyte chemotactic protein-1 (MCP-1) in humans. Estradiol 35-44 C-C motif chemokine ligand 2 Homo sapiens 69-99 12123781-0 2002 Female gender, menstrual cycle and estradiol affect plasma levels of monocyte chemotactic protein-1 (MCP-1) in humans. Estradiol 35-44 C-C motif chemokine ligand 2 Homo sapiens 101-106 12149103-5 2002 Similarly, enalapril decreased plasma levels of MCP-1 by 13% (P<0.001). Enalapril 11-20 C-C motif chemokine ligand 2 Homo sapiens 48-53 12112780-9 2002 TA MCP-1 but not IL-8 concentrations were significantly higher in infants who were oxygen-dependent at 36 weeks postconceptional age. Oxygen 83-89 C-C motif chemokine ligand 2 Homo sapiens 3-8 12115542-7 2002 Owing to a decrease in the secretion of MCP-1 and transforming growth factor-beta 1 (TGF-beta 1), tumor cells treated with RA were unable to induce peripheral blood monocyte (PBM) chemotaxis. Tretinoin 123-125 C-C motif chemokine ligand 2 Homo sapiens 40-45 12117739-7 2002 Serum concentrations of 8-isoprostane, monocyte chemoattractant protein-1, and soluble intercellular adhesion molecule-1 were significantly reduced by candesartan treatment but not by placebo or felodipine (ELISA assays). candesartan 151-162 C-C motif chemokine ligand 2 Homo sapiens 39-73 12149103-8 2002 Eight weeks of antihypertensive treatment with enalapril but not losartan, significantly decreased plasma levels of cAMs and MCP-1 in hypertensive patients. Enalapril 47-56 C-C motif chemokine ligand 2 Homo sapiens 125-130 12117737-7 2002 Furthermore, simvastatin decreased the expression of IL-6, IL-8, and monocyte chemoattractant protein-1 mRNA in peripheral blood mononuclear cells. Simvastatin 13-24 C-C motif chemokine ligand 2 Homo sapiens 69-103 12100898-7 2002 There was also early upregulation of RANTES and MCP-1 in the BOS group (mean 253 +/- 323 and 152 +/- 80 days, respectively, before diagnosis of BOS). N-[4-(Aminosulfonyl)phenyl]-2-Mercaptobenzamide 61-64 C-C motif chemokine ligand 2 Homo sapiens 48-53 12082363-8 2002 However, MPA antagonized the E(2)-induced significant reduction of MCP-1 synthesis, with the difference between both progestins being significant (p < 0.01). Estradiol 29-33 C-C motif chemokine ligand 2 Homo sapiens 67-72 11997318-6 2002 Furthermore, an antisense oligodeoxyribonucleotide targeted against TRAF6 mRNA blunted p38 and SAPK/JNK but not ERK1/2 MAPK activities, as well as IL-8 and MCP-1 production, arguing that TRAF6 is an upstream activator. Oligodeoxyribonucleotides 26-50 C-C motif chemokine ligand 2 Homo sapiens 156-161 12590873-0 2002 Cetirizine, a second-generation H1 antagonist, modulates Rantes and MCP-1 levels in allergic rhinitis. Cetirizine 0-10 C-C motif chemokine ligand 2 Homo sapiens 68-73 12067898-6 2002 Pretreatment with pertussis toxin, GF109203X, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 release, suggesting the involvement of G(i) proteins, protein kinase C, and nuclear factor-kappaB (NF-kappaB). bisindolylmaleimide I 35-44 C-C motif chemokine ligand 2 Homo sapiens 88-93 12067898-6 2002 Pretreatment with pertussis toxin, GF109203X, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 release, suggesting the involvement of G(i) proteins, protein kinase C, and nuclear factor-kappaB (NF-kappaB). pyrrolidine dithiocarbamic acid 50-77 C-C motif chemokine ligand 2 Homo sapiens 88-93 12067898-8 2002 PD98059 prevented MCP-1-induced extracellular signal-regulated kinase activation and cell proliferation. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 0-7 C-C motif chemokine ligand 2 Homo sapiens 18-23 12039983-6 2002 Pretreatment with pertussis toxin, GF109203X, BAPTA-AM, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 and ICAM-1 synthesis, suggesting the involvement of Gi-proteins, protein kinase C, intracellular Ca(2+), and nuclear factor-kappaB (NF-kappaB) in MCP-1 signaling. bisindolylmaleimide I 35-44 C-C motif chemokine ligand 2 Homo sapiens 98-103 12039983-6 2002 Pretreatment with pertussis toxin, GF109203X, BAPTA-AM, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 and ICAM-1 synthesis, suggesting the involvement of Gi-proteins, protein kinase C, intracellular Ca(2+), and nuclear factor-kappaB (NF-kappaB) in MCP-1 signaling. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 46-54 C-C motif chemokine ligand 2 Homo sapiens 98-103 12039983-6 2002 Pretreatment with pertussis toxin, GF109203X, BAPTA-AM, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 and ICAM-1 synthesis, suggesting the involvement of Gi-proteins, protein kinase C, intracellular Ca(2+), and nuclear factor-kappaB (NF-kappaB) in MCP-1 signaling. 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester 46-54 C-C motif chemokine ligand 2 Homo sapiens 265-270 12039983-6 2002 Pretreatment with pertussis toxin, GF109203X, BAPTA-AM, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 and ICAM-1 synthesis, suggesting the involvement of Gi-proteins, protein kinase C, intracellular Ca(2+), and nuclear factor-kappaB (NF-kappaB) in MCP-1 signaling. pyrrolidine dithiocarbamic acid 60-87 C-C motif chemokine ligand 2 Homo sapiens 98-103 12039983-6 2002 Pretreatment with pertussis toxin, GF109203X, BAPTA-AM, and pyrrolidine dithiocarbamate inhibited MCP-1-dependent IL-6 and ICAM-1 synthesis, suggesting the involvement of Gi-proteins, protein kinase C, intracellular Ca(2+), and nuclear factor-kappaB (NF-kappaB) in MCP-1 signaling. pyrrolidine dithiocarbamic acid 60-87 C-C motif chemokine ligand 2 Homo sapiens 265-270 12039983-9 2002 In the present experiments, NF-kappaB and AP-1 were involved in the MCP-1-mediated induction of IL-6, as demonstrated by cis element double-stranded (decoy) oligonucleotides (ODN). Oligonucleotides 155-173 C-C motif chemokine ligand 2 Homo sapiens 68-73 12039983-9 2002 In the present experiments, NF-kappaB and AP-1 were involved in the MCP-1-mediated induction of IL-6, as demonstrated by cis element double-stranded (decoy) oligonucleotides (ODN). odn 175-178 C-C motif chemokine ligand 2 Homo sapiens 68-73 11961005-11 2002 Either antioxidants or PKC inhibitor almost completely abolished the upregulation of the monocyte chemoattractant protein-1 gene induced by excess albumin, as evaluated by real-time PCR, thus supporting a role for PKC and ROS as critical signals for the expression of NF-kappaB-dependent inflammatory genes. Reactive Oxygen Species 222-225 C-C motif chemokine ligand 2 Homo sapiens 89-123 12590873-6 2002 Baseline serum levels of RANTES and MCP-1 chemokines were significantly higher (p &lt; 0.02 and p = 0.007, respectively) in allergic patients than in the healthy control group. Adenosine Monophosphate 83-86 C-C motif chemokine ligand 2 Homo sapiens 36-41 12590873-7 2002 Cetirizine resulted in a significant decrease in RANTES (p &lt; 0.02) and MCP-1 (p = 0.003) versus baseline values. Cetirizine 0-10 C-C motif chemokine ligand 2 Homo sapiens 78-83 12590873-8 2002 There is an increase in RANTES and MCP-1 in allergic rhinitis, which is counteracted by cetirizine. Cetirizine 88-98 C-C motif chemokine ligand 2 Homo sapiens 35-40 12015158-5 2002 Furthermore, berry polyphenols also reduced TNFalpha induced up-regulation of various inflammatory mediators (IL-8, MCP-1 and ICAM-1) involved in the recruitment of leukocytes to sites of damage or inflammation along the endothelium. Polyphenols 19-30 C-C motif chemokine ligand 2 Homo sapiens 116-121 12038622-0 2002 Titanium particles induce the immediate early stress responsive chemokines IL-8 and MCP-1 in osteoblasts. Titanium 0-8 C-C motif chemokine ligand 2 Homo sapiens 84-89 12038622-3 2002 In this study, we now demonstrate that Ti particles can rapidly induce the chemotactic cytokines interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1), two immediate early stress responsive chemokines important for the activation and chemotaxis of neutrophils and macrophages, respectively. Titanium 39-41 C-C motif chemokine ligand 2 Homo sapiens 122-156 12038622-3 2002 In this study, we now demonstrate that Ti particles can rapidly induce the chemotactic cytokines interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1), two immediate early stress responsive chemokines important for the activation and chemotaxis of neutrophils and macrophages, respectively. Titanium 39-41 C-C motif chemokine ligand 2 Homo sapiens 158-163 12038622-6 2002 Actinomycin D, a potent RNA polymerase II inhibitor, blocked the Ti particle induction of IL-8 and MCP-1 mRNA expression, whereas cycloheximide, which inhibits protein synthesis, failed to inhibit chemokine gene expression suggesting Ti particles directly target activation of chemokine gene transcription. Dactinomycin 0-13 C-C motif chemokine ligand 2 Homo sapiens 99-104 12038622-8 2002 Taken together, these data demonstrate that Ti particles can activate transcription of the stress responsive chemokine genes IL-8 and MCP-1 in human osteoblasts. Titanium 44-46 C-C motif chemokine ligand 2 Homo sapiens 134-139 11937582-7 2002 MCP-1 mRNA expression was also up-regulated when HUVEC were incubated with either APS-IgG or monoclonal aCL, and down-regulated by the treatment of dexamethasone. Dexamethasone 148-161 C-C motif chemokine ligand 2 Homo sapiens 0-5 11937582-9 2002 Collectively, these results indicate that aCL could promote endothelial cell-monocyte cross-talk by enhancing the endothelial production of MCP-1, thereby shifting the hemostatic balance toward the prothrombotic state of APS. Adenosine Phosphosulfate 221-224 C-C motif chemokine ligand 2 Homo sapiens 140-145 11931709-0 2002 Reduction in monocyte chemoattractant protein-1 mRNA expression in peripheral blood mononuclear cells of diamorphine addicts. Heroin 105-116 C-C motif chemokine ligand 2 Homo sapiens 13-47 11931709-1 2002 AIM: To investigate whether there is a significant difference in the monocyte chemoattractant protein-1 (MCP-1) mRNA expression between diamorphine ( heroin) addicts and normal volunteers. Heroin 136-147 C-C motif chemokine ligand 2 Homo sapiens 105-110 11931709-2 2002 METHODS: Expression of MCP-1 mRNA in the peripheral blood mononuclear cells of diamorphine addicts and normal volunteers was examine d by reverse transcription-polymerase chain reaction (RT-PCR) with beta -actin as a n internal standard. Heroin 79-90 C-C motif chemokine ligand 2 Homo sapiens 23-28 11931709-5 2002 CONCLUSION: The significant reduction of MCP-1 mRNA expression in the peripheral blood mononuclear cells of diamorphine addicts may be one of the mechanisms for the high incidence o f severe infectious diseases, including AIDS, among diamorphine addicts. Heroin 108-119 C-C motif chemokine ligand 2 Homo sapiens 41-46 11931709-5 2002 CONCLUSION: The significant reduction of MCP-1 mRNA expression in the peripheral blood mononuclear cells of diamorphine addicts may be one of the mechanisms for the high incidence o f severe infectious diseases, including AIDS, among diamorphine addicts. Heroin 234-245 C-C motif chemokine ligand 2 Homo sapiens 41-46 11756069-9 2002 In addition, treatment with this fatty acid markedly enhanced messenger RNA levels of tumor necrosis factor alpha, monocyte chemoattractant protein 1, vascular cell adhesion molecule 1, and intercellular adhesion molecule 1. Fatty Acids 33-43 C-C motif chemokine ligand 2 Homo sapiens 115-149 11912248-0 2002 Role of high glucose-induced nuclear factor-kappaB activation in monocyte chemoattractant protein-1 expression by mesangial cells. Glucose 13-20 C-C motif chemokine ligand 2 Homo sapiens 65-99 11872210-0 2002 Estradiol down-regulates MCP-1 expression in human coronary artery endothelial cells. Estradiol 0-9 C-C motif chemokine ligand 2 Homo sapiens 25-30 11872210-11 2002 On the other hand, in HCAEC, estradiol induced a 30% decrease in mRNA expression and resulted in dose-dependent inhibition of MCP-1 production as detected by ELISA. Estradiol 29-38 C-C motif chemokine ligand 2 Homo sapiens 126-131 11872210-12 2002 Raloxifene and tamoxifen also resulted in inhibition of MCP-1 mRNA and protein expression. Raloxifene Hydrochloride 0-10 C-C motif chemokine ligand 2 Homo sapiens 56-61 11872210-12 2002 Raloxifene and tamoxifen also resulted in inhibition of MCP-1 mRNA and protein expression. Tamoxifen 15-24 C-C motif chemokine ligand 2 Homo sapiens 56-61 11861035-0 2002 The effect of 17 beta-estradiol on MCP-1 serum levels in postmenopausal women. Estradiol 14-31 C-C motif chemokine ligand 2 Homo sapiens 35-40 11959378-8 2002 Significant correlations were also found between LDL cholesterol values and plasma inflammatory factors GM-CSF (r=0.58, P=0.0088), MCP-1 (r=0.49, P=0.040) and sICAM-1 (r=0.53, P=0.034) in the hypercholesterolemic sub-group of hypertensives. Cholesterol 53-64 C-C motif chemokine ligand 2 Homo sapiens 131-136 11912286-7 2002 The immunoreactive levels of endometrial IL-8 and MCP-1 were up-regulated by the administration of progesterone during the receptive phase of the cycle. Progesterone 99-111 C-C motif chemokine ligand 2 Homo sapiens 50-55 11813159-7 2002 Furthermore, the broad spectrum MMP inhibitor BB 2516, which inhibits TNF-alpha release, abrogated CCL2- and CCL5-induced MMP-9 release in both THP-1 cells and freshly isolated monocytes. marimastat 46-53 C-C motif chemokine ligand 2 Homo sapiens 99-103 11926313-5 2002 RESULTS: We found that atorvastatin activates PPAR-gamma and inhibits the production of tumour necrosis factor-alpha up to 38% (p < 0.05), monocyte chemoattractant protein-1 up to 85% (p < 0.05), and gelatinase B up to 73% (p < 0.05), in a concentration-dependent manner. Atorvastatin 23-35 C-C motif chemokine ligand 2 Homo sapiens 142-176 11821020-6 2002 The PPARdelta activator L-165041 had the greatest potency to reduce cytokine-induced monocyte chemotactic protein-1 (MCP-1) secretion. 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid 24-32 C-C motif chemokine ligand 2 Homo sapiens 85-115 11821020-6 2002 The PPARdelta activator L-165041 had the greatest potency to reduce cytokine-induced monocyte chemotactic protein-1 (MCP-1) secretion. 4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid 24-32 C-C motif chemokine ligand 2 Homo sapiens 117-122 12503388-1 2002 From natural samples 11 isolates able to remove trichloroethene (CCl2CHCl) from an aqueous environment were obtained which were capable of cometabolic degradation of CCl2CHCl by an enzyme system for phenol degradation. Phenol 199-205 C-C motif chemokine ligand 2 Homo sapiens 65-69 12503388-1 2002 From natural samples 11 isolates able to remove trichloroethene (CCl2CHCl) from an aqueous environment were obtained which were capable of cometabolic degradation of CCl2CHCl by an enzyme system for phenol degradation. Trichloroethylene 48-63 C-C motif chemokine ligand 2 Homo sapiens 65-69 12503388-1 2002 From natural samples 11 isolates able to remove trichloroethene (CCl2CHCl) from an aqueous environment were obtained which were capable of cometabolic degradation of CCl2CHCl by an enzyme system for phenol degradation. Trichloroethylene 48-63 C-C motif chemokine ligand 2 Homo sapiens 166-170 12503388-1 2002 From natural samples 11 isolates able to remove trichloroethene (CCl2CHCl) from an aqueous environment were obtained which were capable of cometabolic degradation of CCl2CHCl by an enzyme system for phenol degradation. Phenol 199-205 C-C motif chemokine ligand 2 Homo sapiens 166-170 12503388-4 2002 This culture degraded CCl2CHCl even at a low inoculum concentration and attained a transformation capacity of 14.7 mg CCl2CHCl per g. The increase in chloride concentration after degradation was quantitative when compared with the decrease in organically bound chlorine. Chlorides 150-158 C-C motif chemokine ligand 2 Homo sapiens 22-26 12503388-4 2002 This culture degraded CCl2CHCl even at a low inoculum concentration and attained a transformation capacity of 14.7 mg CCl2CHCl per g. The increase in chloride concentration after degradation was quantitative when compared with the decrease in organically bound chlorine. Chlorides 150-158 C-C motif chemokine ligand 2 Homo sapiens 118-122 12503388-4 2002 This culture degraded CCl2CHCl even at a low inoculum concentration and attained a transformation capacity of 14.7 mg CCl2CHCl per g. The increase in chloride concentration after degradation was quantitative when compared with the decrease in organically bound chlorine. Chlorine 261-269 C-C motif chemokine ligand 2 Homo sapiens 22-26 12503388-4 2002 This culture degraded CCl2CHCl even at a low inoculum concentration and attained a transformation capacity of 14.7 mg CCl2CHCl per g. The increase in chloride concentration after degradation was quantitative when compared with the decrease in organically bound chlorine. Chlorine 261-269 C-C motif chemokine ligand 2 Homo sapiens 118-122 12503388-5 2002 The degree of CCl2CHCl degradation was affected by Me2S2; this substance can significantly reduce the degrading ability of some tested cultures (> 60%); however, it does not cause this inhibition with others. me2s2 51-56 C-C motif chemokine ligand 2 Homo sapiens 14-18 11799073-4 2002 GSA increased expression of early response genes, c-fos and c-jun, and inflammatory genes, monocyte chemoattractant peptide (MCP-1), and interleukin (IL)-6. gsa 0-3 C-C motif chemokine ligand 2 Homo sapiens 125-130 11799073-6 2002 One of signaling pathways by which GSA activates VSMCs appears to be via nuclear factor kappaB activation, leading to induction of MCP-1 and IL-6 gene expression, comparable to the effects of lipopolysaccharide, TNF-alphaa, and IL-1alphab. gsa 35-38 C-C motif chemokine ligand 2 Homo sapiens 131-136 15080492-11 2002 RESULTS: Plasma levels of MCP-1 were significantly higher (261.5+/-40.7 pg/mL vs 73.3+/-3.05 pg/mL; p<0.0002) and also levels of PAI-1 were higher (79.36+/-5.8 ng/mL vs 35.88+/-1.38 ng/mL; p<0.0001) in patients with SA compared with the healthy control subjects. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 222-224 C-C motif chemokine ligand 2 Homo sapiens 26-31 11799073-6 2002 One of signaling pathways by which GSA activates VSMCs appears to be via nuclear factor kappaB activation, leading to induction of MCP-1 and IL-6 gene expression, comparable to the effects of lipopolysaccharide, TNF-alphaa, and IL-1alphab. vsmcs 49-54 C-C motif chemokine ligand 2 Homo sapiens 131-136 11799073-9 2002 Incubation of VSMCs with the antioxidant N-acetylcysteine suppressed GSA-elicited mRNA induction of MCP-1 and IL-6. vsmcs 14-19 C-C motif chemokine ligand 2 Homo sapiens 100-105 11799073-9 2002 Incubation of VSMCs with the antioxidant N-acetylcysteine suppressed GSA-elicited mRNA induction of MCP-1 and IL-6. Acetylcysteine 41-57 C-C motif chemokine ligand 2 Homo sapiens 100-105 11799073-9 2002 Incubation of VSMCs with the antioxidant N-acetylcysteine suppressed GSA-elicited mRNA induction of MCP-1 and IL-6. gsa 69-72 C-C motif chemokine ligand 2 Homo sapiens 100-105 11835523-9 2002 High glucose may stimulate MCP-1 and/or IL-8 production and their excretion into the urine independently of the phases or pathological lesions of this disease. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 27-32 11764208-1 2001 OBJECTIVE: To determine the effect of pulse methyprednisolone (PMP; 1000 mg) on the expression of monocyte chemoattractant protein (MCP)-1 and macrophage inflammatory protein (MIP)-1alpha in rheumatoid synovial membrane. methyprednisolone 44-61 C-C motif chemokine ligand 2 Homo sapiens 98-138 11742868-4 2001 Treatment of ECs with S-nitroso-N-acetylpenicillamine (SNAP), an NO donor, reduced cyclic strain-induced monocyte chemotactic protein (MCP)-1 expression. S-Nitroso-N-Acetylpenicillamine 22-53 C-C motif chemokine ligand 2 Homo sapiens 105-141 11742868-4 2001 Treatment of ECs with S-nitroso-N-acetylpenicillamine (SNAP), an NO donor, reduced cyclic strain-induced monocyte chemotactic protein (MCP)-1 expression. S-Nitroso-N-Acetylpenicillamine 55-59 C-C motif chemokine ligand 2 Homo sapiens 105-141 11742868-6 2001 NO attenuated the binding of activator protein-1 to the 12-O-tetradecanoylphobol-13-acetate-responsive element (TRE) in the MCP-1 promoter region. 12-o-tetradecanoylphobol-13-acetate 56-91 C-C motif chemokine ligand 2 Homo sapiens 124-129 11742868-9 2001 These strain-induced superoxide and MCP-1 expressions were greatly blunted by treating ECs with an NADPH oxidase inhibitor, diphenyleneiodonium chloride or apocynine, but not with a xanthine oxidase inhibitor. diphenyleneiodonium 124-152 C-C motif chemokine ligand 2 Homo sapiens 36-41 11742868-9 2001 These strain-induced superoxide and MCP-1 expressions were greatly blunted by treating ECs with an NADPH oxidase inhibitor, diphenyleneiodonium chloride or apocynine, but not with a xanthine oxidase inhibitor. acetovanillone 156-165 C-C motif chemokine ligand 2 Homo sapiens 36-41 11742868-14 2001 Our results show that NO from eNOS-inhibiting redox-sensitive MCP-1 expression is mediated via Rac-dependent NADPH oxidase by reducing ROS. Reactive Oxygen Species 135-138 C-C motif chemokine ligand 2 Homo sapiens 62-67 11764208-1 2001 OBJECTIVE: To determine the effect of pulse methyprednisolone (PMP; 1000 mg) on the expression of monocyte chemoattractant protein (MCP)-1 and macrophage inflammatory protein (MIP)-1alpha in rheumatoid synovial membrane. pmp 63-66 C-C motif chemokine ligand 2 Homo sapiens 98-138 11764208-6 2001 RESULTS: PMP therapy was associated with a rapid (within 24 hours) and substantial decrease in the expression of MCP-1 and MIP-1alpha expression by a mean of 55% (p = 0.05) and 45% (p = 0.03), respectively, with no effect on CD68 expression in the synovial lining layer. pmp 9-12 C-C motif chemokine ligand 2 Homo sapiens 113-118 11784351-9 2001 The concentration of CCL2 increased between baseline for 3 weeks in both groups, more distinctly so in patients treated with methylprednisolone. Methylprednisolone 125-143 C-C motif chemokine ligand 2 Homo sapiens 21-25 11559700-5 2001 In addition, whereas 1 microm concentrations of eotaxin were able to recruit CCR2b transfectants, substimulatory concentrations of eotaxin inhibited MCP-1-induced chemotaxis of CCR2b transfectants and also inhibited MCP-1-induced intracellular calcium flux of THP-1 cells. Calcium 244-251 C-C motif chemokine ligand 2 Homo sapiens 149-154 11689202-0 2001 Dietary hematein ameliorates fatty streak lesions in the rabbit by the possible mechanism of reducing VCAM-1 and MCP-1 expression. hematein 8-16 C-C motif chemokine ligand 2 Homo sapiens 113-118 11731619-9 2001 EGF"s negative influence on JAK2 activity was blocked by actinomycin D treatment of HC11 cells, suggesting that EGF induced a protein that mediated the effects of PTP-PEST on JAK2. Dactinomycin 57-70 C-C motif chemokine ligand 2 Homo sapiens 84-88 11700035-5 2001 The interaction of BP with IFN-gamma inhibited the cytokine"s detection by immunoassay and impaired its activity, as assessed in three different assays: upregulation of MHC molecules on monocytes plus induction of nitric oxide synthesis and expression of monocyte chemoattractant protein-1 mRNA by epithelial cells. Penicillin G 19-21 C-C motif chemokine ligand 2 Homo sapiens 255-289 12031258-0 2001 Linoleic acid induces MCP-1 gene expression in human microvascular endothelial cells through an oxidative mechanism. Linoleic Acid 0-13 C-C motif chemokine ligand 2 Homo sapiens 22-27 11673556-6 2001 Moreover, activation of ERK1/2 was inhibited by pertussis toxin, a G(i)-coupled protein inhibitor, and RS-504393, CCR2 antagonist, suggesting that ERK1/2 was activated by CCL2 via CCR2 and G(i)-coupled protein. RS 504393 103-112 C-C motif chemokine ligand 2 Homo sapiens 171-175 12031258-4 2001 The present study focused on the mechanisms of linoleic acid-induced expression of monocyte chemoattractant protein-1 (MCP-1) gene in human microvascular endothelial cells (HMEC-1). Linoleic Acid 47-60 C-C motif chemokine ligand 2 Homo sapiens 83-117 12031258-4 2001 The present study focused on the mechanisms of linoleic acid-induced expression of monocyte chemoattractant protein-1 (MCP-1) gene in human microvascular endothelial cells (HMEC-1). Linoleic Acid 47-60 C-C motif chemokine ligand 2 Homo sapiens 119-124 12031258-6 2001 In addition, exposure to linoleic acid induced a time- and concentration-dependent overexpression of the MCP-1 gene. Linoleic Acid 25-38 C-C motif chemokine ligand 2 Homo sapiens 105-110 12031258-7 2001 Increased MCP-1 mRNA levels were observed in HMEC-1 treated with linoleic acid at doses as low as 10 &mgr;M. Linoleic acid-induced overexpression of the MCP-1 gene was associated with a significant elevation of MCP-1 protein levels. Linoleic Acid 65-78 C-C motif chemokine ligand 2 Homo sapiens 10-15 12031258-7 2001 Increased MCP-1 mRNA levels were observed in HMEC-1 treated with linoleic acid at doses as low as 10 &mgr;M. Linoleic acid-induced overexpression of the MCP-1 gene was associated with a significant elevation of MCP-1 protein levels. Linoleic Acid 65-78 C-C motif chemokine ligand 2 Homo sapiens 157-162 12031258-7 2001 Increased MCP-1 mRNA levels were observed in HMEC-1 treated with linoleic acid at doses as low as 10 &mgr;M. Linoleic acid-induced overexpression of the MCP-1 gene was associated with a significant elevation of MCP-1 protein levels. Linoleic Acid 65-78 C-C motif chemokine ligand 2 Homo sapiens 157-162 12031258-7 2001 Increased MCP-1 mRNA levels were observed in HMEC-1 treated with linoleic acid at doses as low as 10 &mgr;M. Linoleic acid-induced overexpression of the MCP-1 gene was associated with a significant elevation of MCP-1 protein levels. Adenosine Monophosphate 102-105 C-C motif chemokine ligand 2 Homo sapiens 10-15 12031258-7 2001 Increased MCP-1 mRNA levels were observed in HMEC-1 treated with linoleic acid at doses as low as 10 &mgr;M. Linoleic acid-induced overexpression of the MCP-1 gene was associated with a significant elevation of MCP-1 protein levels. Adenosine Monophosphate 102-105 C-C motif chemokine ligand 2 Homo sapiens 157-162 12031258-7 2001 Increased MCP-1 mRNA levels were observed in HMEC-1 treated with linoleic acid at doses as low as 10 &mgr;M. Linoleic acid-induced overexpression of the MCP-1 gene was associated with a significant elevation of MCP-1 protein levels. Adenosine Monophosphate 102-105 C-C motif chemokine ligand 2 Homo sapiens 157-162 12031258-7 2001 Increased MCP-1 mRNA levels were observed in HMEC-1 treated with linoleic acid at doses as low as 10 &mgr;M. Linoleic acid-induced overexpression of the MCP-1 gene was associated with a significant elevation of MCP-1 protein levels. Linoleic Acid 113-126 C-C motif chemokine ligand 2 Homo sapiens 10-15 12031258-7 2001 Increased MCP-1 mRNA levels were observed in HMEC-1 treated with linoleic acid at doses as low as 10 &mgr;M. Linoleic acid-induced overexpression of the MCP-1 gene was associated with a significant elevation of MCP-1 protein levels. Linoleic Acid 113-126 C-C motif chemokine ligand 2 Homo sapiens 157-162 12031258-7 2001 Increased MCP-1 mRNA levels were observed in HMEC-1 treated with linoleic acid at doses as low as 10 &mgr;M. Linoleic acid-induced overexpression of the MCP-1 gene was associated with a significant elevation of MCP-1 protein levels. Linoleic Acid 113-126 C-C motif chemokine ligand 2 Homo sapiens 157-162 12031258-8 2001 Most importantly, preexposure of HMEC-1 to antioxidants, such as pyrrolidine dithiocarbamate (PDTC) or N-acetylcysteine (NAC), attenuated linoleic acid-induced MCP-1 mRNA expression. pyrrolidine dithiocarbamic acid 65-92 C-C motif chemokine ligand 2 Homo sapiens 160-165 12031258-8 2001 Most importantly, preexposure of HMEC-1 to antioxidants, such as pyrrolidine dithiocarbamate (PDTC) or N-acetylcysteine (NAC), attenuated linoleic acid-induced MCP-1 mRNA expression. pyrrolidine dithiocarbamic acid 94-98 C-C motif chemokine ligand 2 Homo sapiens 160-165 12031258-8 2001 Most importantly, preexposure of HMEC-1 to antioxidants, such as pyrrolidine dithiocarbamate (PDTC) or N-acetylcysteine (NAC), attenuated linoleic acid-induced MCP-1 mRNA expression. Acetylcysteine 103-119 C-C motif chemokine ligand 2 Homo sapiens 160-165 12031258-8 2001 Most importantly, preexposure of HMEC-1 to antioxidants, such as pyrrolidine dithiocarbamate (PDTC) or N-acetylcysteine (NAC), attenuated linoleic acid-induced MCP-1 mRNA expression. Acetylcysteine 121-124 C-C motif chemokine ligand 2 Homo sapiens 160-165 12031258-8 2001 Most importantly, preexposure of HMEC-1 to antioxidants, such as pyrrolidine dithiocarbamate (PDTC) or N-acetylcysteine (NAC), attenuated linoleic acid-induced MCP-1 mRNA expression. Linoleic Acid 138-151 C-C motif chemokine ligand 2 Homo sapiens 160-165 12031258-9 2001 The obtained results indicate that linoleic acid triggers MCP-1 gene expression in human microvascular endothelial cells through oxidative stress/redox-related mechanisms. Linoleic Acid 35-48 C-C motif chemokine ligand 2 Homo sapiens 58-63 11591574-0 2001 Inhibition of monocyte chemoattractant protein-1 expression in cytokine-treated human lung epithelial cells by thiazolidinedione. 2,4-thiazolidinedione 111-128 C-C motif chemokine ligand 2 Homo sapiens 14-48 11641460-0 2001 Monocyte chemoattractant protein-1 and its receptor CCR-2 in piglet lungs exposed to inhaled nitric oxide and hyperoxia. Nitric Oxide 93-105 C-C motif chemokine ligand 2 Homo sapiens 0-34 11591574-5 2001 In the present study, we examined the effects of a thiazolidinedione (TZD), which is used to improve the insulin resistance of individuals with diabetes mellitus, on MCP-1 expression in a human lung epithelial cell line, A549. 2,4-thiazolidinedione 51-68 C-C motif chemokine ligand 2 Homo sapiens 166-171 11591574-5 2001 In the present study, we examined the effects of a thiazolidinedione (TZD), which is used to improve the insulin resistance of individuals with diabetes mellitus, on MCP-1 expression in a human lung epithelial cell line, A549. 2,4-thiazolidinedione 70-73 C-C motif chemokine ligand 2 Homo sapiens 166-171 11591574-7 2001 The TZD inhibited the increase of MCP-1 secretion by IL-1beta and TNF-alpha treatment. 2,4-thiazolidinedione 4-7 C-C motif chemokine ligand 2 Homo sapiens 34-39 11591574-8 2001 The TZD inhibited the expression of MCP-1 messenger RNA with IL-1beta treatment, but not with TNF-alpha treatment. 2,4-thiazolidinedione 4-7 C-C motif chemokine ligand 2 Homo sapiens 36-41 11591574-11 2001 CONCLUSIONS: Our findings indicated that the suppression of the expression of MCP-1 could be accomplished by TZD treatment, raising the possibility that TZD may be of therapeutic value in several lung diseases in which MCP-1 plays an important role. 2,4-thiazolidinedione 109-112 C-C motif chemokine ligand 2 Homo sapiens 78-83 11591574-11 2001 CONCLUSIONS: Our findings indicated that the suppression of the expression of MCP-1 could be accomplished by TZD treatment, raising the possibility that TZD may be of therapeutic value in several lung diseases in which MCP-1 plays an important role. 2,4-thiazolidinedione 109-112 C-C motif chemokine ligand 2 Homo sapiens 219-224 11591574-11 2001 CONCLUSIONS: Our findings indicated that the suppression of the expression of MCP-1 could be accomplished by TZD treatment, raising the possibility that TZD may be of therapeutic value in several lung diseases in which MCP-1 plays an important role. 2,4-thiazolidinedione 153-156 C-C motif chemokine ligand 2 Homo sapiens 78-83 11591574-11 2001 CONCLUSIONS: Our findings indicated that the suppression of the expression of MCP-1 could be accomplished by TZD treatment, raising the possibility that TZD may be of therapeutic value in several lung diseases in which MCP-1 plays an important role. 2,4-thiazolidinedione 153-156 C-C motif chemokine ligand 2 Homo sapiens 219-224 11590385-8 2001 MCP-1 induces chemotaxis and calcium mobilization in eosinophils. Calcium 29-36 C-C motif chemokine ligand 2 Homo sapiens 0-5 11713366-9 2001 No substantial HIV RNA accumulation was demonstrated in U1 cells co-stimulated with IL-6 and Dex, whereas IL-6 upregulated the expression of MCP-1 RNA, and this effect was inhibited by Dex. Dexamethasone 185-188 C-C motif chemokine ligand 2 Homo sapiens 141-146 11687892-0 2001 Enhanced anti-tumor effects of herpes simplex virus thymidine kinase/ganciclovir system by codelivering monocyte chemoattractant protein-1 in hepatocellular carcinoma. Ganciclovir 69-80 C-C motif chemokine ligand 2 Homo sapiens 104-138 11687892-2 2001 In the current study, we investigated whether adenovirally delivered monocyte chemoattractant protein (MCP)-1 potentiates the antitumor effects of the HSV-tk/GCV system in hepatocellular carcinoma (HCC) cells. Ganciclovir 158-161 C-C motif chemokine ligand 2 Homo sapiens 69-109 11687892-7 2001 The antitumor effects of the rAd expressing MCP-1 were markedly reduced by the administration of carrageenan, a compound known to inactivate macrophage. Carrageenan 97-108 C-C motif chemokine ligand 2 Homo sapiens 44-49 11687892-8 2001 These results indicate that adenovirally delivered MCP-1 enhanced the antitumor effects of the HSV-tk/GCV system synergistically by recruitment/activation of macrophages in tumor tissues, suggesting an effective immunotherapy for HCC and other lineages of tumors when used adjuvantly with a suicide gene. Ganciclovir 102-105 C-C motif chemokine ligand 2 Homo sapiens 51-56 11544333-0 2001 Calcium-independent phospholipase A(2) is required for human monocyte chemotaxis to monocyte chemoattractant protein 1. Calcium 0-7 C-C motif chemokine ligand 2 Homo sapiens 84-118 11544333-6 2001 Using antisense oligodeoxyribonucleotide treatment we found that iPLA(2) expression is required for monocyte migration to MCP-1. Oligodeoxyribonucleotides 16-40 C-C motif chemokine ligand 2 Homo sapiens 122-127 11549724-7 2001 Bz-ATP also increased MCP-1 expression in cultured astrocytes, and again P2X7 antagonists prevented this increase. 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate 0-6 C-C motif chemokine ligand 2 Homo sapiens 22-27 11549724-8 2001 Blocking either the ERK1/ERK2 or the p38 pathway (with PD98059 or SB203580, respectively) significantly inhibited Bz-ATP-induced MCP-1 expression. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 55-62 C-C motif chemokine ligand 2 Homo sapiens 129-134 11549724-8 2001 Blocking either the ERK1/ERK2 or the p38 pathway (with PD98059 or SB203580, respectively) significantly inhibited Bz-ATP-induced MCP-1 expression. SB 203580 66-74 C-C motif chemokine ligand 2 Homo sapiens 129-134 11549724-8 2001 Blocking either the ERK1/ERK2 or the p38 pathway (with PD98059 or SB203580, respectively) significantly inhibited Bz-ATP-induced MCP-1 expression. Quinuclidinyl Benzilate 114-116 C-C motif chemokine ligand 2 Homo sapiens 129-134 11544333-8 2001 In reconstitution experiments, lysophosphatidic acid completely restored MCP-1-stimulated migration in iPLA(2)-deficient monocytes, whereas lysophosphatidic acid was without effect in restoring migration in cPLA(2)-deficient monocytes. lysophosphatidic acid 31-52 C-C motif chemokine ligand 2 Homo sapiens 73-78 11595074-7 2001 The pretreatment with interferon (IFN)-gamma markedly enhanced the effects of Fas Ag stimulation; IFN-gamma pretreatment and Fas Ag stimulation synergistically induced not only apoptosis but also IL-8 and MCP-1 secretion. ammonium ferrous sulfate 125-128 C-C motif chemokine ligand 2 Homo sapiens 205-210 11549724-8 2001 Blocking either the ERK1/ERK2 or the p38 pathway (with PD98059 or SB203580, respectively) significantly inhibited Bz-ATP-induced MCP-1 expression. Adenosine Triphosphate 117-120 C-C motif chemokine ligand 2 Homo sapiens 129-134 11549724-12 2001 Suramin, a wide-spectrum purinergic receptor antagonist, significantly depressed the rapid (3 hr) trauma-induced increase in MCP-1 mRNA. Suramin 0-7 C-C motif chemokine ligand 2 Homo sapiens 125-130 11549724-14 2001 The regulation of MCP-1 in astrocytes by ATP may be important in mediating communication with hematopoietic inflammatory cells. Adenosine Triphosphate 41-44 C-C motif chemokine ligand 2 Homo sapiens 18-23 11571719-8 2001 In addition, MCP-1 expression tended to be associated with the accumulation of TAMs, which were counted by CD68 staining, and with microvessel density. tams 79-83 C-C motif chemokine ligand 2 Homo sapiens 13-18 11571719-9 2001 MCP-1 expression in TAMs was correlated significantly with the histologic vessel invasion of tumor cells. tams 20-24 C-C motif chemokine ligand 2 Homo sapiens 0-5 11833849-1 2001 In order to evaluate whether treatment with valproic acid or carbamazepine can modify interleukins and monocyte chemoattractant protein-1, we studied 40 epileptic children and adolescents. Valproic Acid 44-57 C-C motif chemokine ligand 2 Homo sapiens 103-137 11595074-7 2001 The pretreatment with interferon (IFN)-gamma markedly enhanced the effects of Fas Ag stimulation; IFN-gamma pretreatment and Fas Ag stimulation synergistically induced not only apoptosis but also IL-8 and MCP-1 secretion. ammonium ferrous sulfate 78-81 C-C motif chemokine ligand 2 Homo sapiens 205-210 11562149-9 2001 After 24 h, titanium particles maximally upregulated MCP-1 release 7-fold while PMMA particles increased MCP-1 levels 2-fold, when compared to unchallenged fibroblasts. Polymethyl Methacrylate 80-84 C-C motif chemokine ligand 2 Homo sapiens 105-110 11562149-13 2001 Increased release of MCP-1 from fibroblasts exposed to titanium and PMMA particles coincided with increased release of IL-6. Titanium 55-63 C-C motif chemokine ligand 2 Homo sapiens 21-26 11562149-8 2001 The results demonstrated that exposure of fibroblasts to titanium and PMMA particles resulted in increased release of MCP-1 in a dose- and time-dependent manner. Polymethyl Methacrylate 70-74 C-C motif chemokine ligand 2 Homo sapiens 118-123 11468165-5 2001 Using the selective p38 MAPK inhibitor SB203580, there was a significant decrease in thrombin-induced interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) protein production and messenger RNA steady-state levels. SB 203580 39-47 C-C motif chemokine ligand 2 Homo sapiens 127-157 11562149-9 2001 After 24 h, titanium particles maximally upregulated MCP-1 release 7-fold while PMMA particles increased MCP-1 levels 2-fold, when compared to unchallenged fibroblasts. Titanium 12-20 C-C motif chemokine ligand 2 Homo sapiens 53-58 11502881-3 2001 In this study, we investigated the effect of Wog on phorbol ester (PMA)-induced MCP-1 expression in human umbilical vein endothelial cells (ECs). Phorbol Esters 52-65 C-C motif chemokine ligand 2 Homo sapiens 80-85 11502881-3 2001 In this study, we investigated the effect of Wog on phorbol ester (PMA)-induced MCP-1 expression in human umbilical vein endothelial cells (ECs). Tetradecanoylphorbol Acetate 67-70 C-C motif chemokine ligand 2 Homo sapiens 80-85 11502881-6 2001 The inhibition of MCP-1 induction by Wog is a transcriptional event, as shown by Wog"s significant reduction of both MCP-1 promoter and 4x 12-O-tetradecanoylphorbol-13-acetate response element-luciferase reporter activities. 4x 12-o-tetradecanoylphorbol-13-acetate 136-175 C-C motif chemokine ligand 2 Homo sapiens 18-23 11502881-8 2001 Furthermore, the PMA-induced extracellular signal-regulated kinase 1/2 and c-Jun amino-terminal kinase activities that contributed to AP-1 activity and MCP-1 gene induction were obviously attenuated after pretreating ECs with Wog. Tetradecanoylphorbol Acetate 17-20 C-C motif chemokine ligand 2 Homo sapiens 152-157 11502881-10 2001 Taken together, our results demonstrate that Wog inhibits MCP-1 induction in ECs; this inhibition is mediated by reducing AP-1 transcriptional activity via the attenuation of ERK1/2 and JNK signal transduction pathways. wogonin 45-48 C-C motif chemokine ligand 2 Homo sapiens 58-63 11536042-5 2001 Expression of Int6sh in MCF10A and HC11 mammary epithelial cells leads to anchorage-independent growth in soft agar indicative of a transformed phenotype. Agar 111-115 C-C motif chemokine ligand 2 Homo sapiens 35-39 11471095-6 2001 MIP-1alpha and MCP-1 levels also were inversely related to oxygen saturation (P<.005). Oxygen 59-65 C-C motif chemokine ligand 2 Homo sapiens 15-20 11520061-1 2001 Extracellular magnesium (Mg) depletion inhibits the growth of the HC11 normal mammary epithelial cells. Magnesium 14-23 C-C motif chemokine ligand 2 Homo sapiens 66-70 11520061-1 2001 Extracellular magnesium (Mg) depletion inhibits the growth of the HC11 normal mammary epithelial cells. Magnesium 25-27 C-C motif chemokine ligand 2 Homo sapiens 66-70 11520061-7 2001 Cell total Mg content was 19.6, 9.7, and 20.1 nmol/mg protein in the HC11, HC-LMg, and HC-HMg cells, respectively. Magnesium 11-13 C-C motif chemokine ligand 2 Homo sapiens 69-73 11468165-5 2001 Using the selective p38 MAPK inhibitor SB203580, there was a significant decrease in thrombin-induced interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) protein production and messenger RNA steady-state levels. SB 203580 39-47 C-C motif chemokine ligand 2 Homo sapiens 159-164 11468165-6 2001 In addition, SB203580 decreased IL-8 and MCP-1 production induced by the thrombin receptor-1 agonist peptide (TRAP), suggesting functional links between the thrombin G protein-coupled receptor and the p38 MAPK pathway. SB 203580 13-21 C-C motif chemokine ligand 2 Homo sapiens 41-46 11672583-8 2001 In support of other studies, we also found that exogenously added nitric oxide (NO) inhibited MCP-1 production. Nitric Oxide 66-78 C-C motif chemokine ligand 2 Homo sapiens 94-99 11463608-4 2001 We hypothesized that the severity of pulmonary hypertension may be related to MCP-1, which is thought to be upregulated by blood pressure or shear stress in pulmonary vasculature as well as by immunological and inflammatory reactions in chronic thromboembolic pulmonary hypertension (CTEPH). cteph 284-289 C-C motif chemokine ligand 2 Homo sapiens 78-83 11278864-4 2001 The activity of PI3Kalpha in purified human monocytes was evident within 30 s. MCP-1-induced monocyte arrest was significantly inhibited both by wortmannin (n = 4; p < 0.01) and LY294002 (n = 4; p < 0.01) with restoration of the rolling phenotype (p < 0.05 for both inhibitors, compared with rolling of control monocytes after MCP-1 treatment). Wortmannin 145-155 C-C motif chemokine ligand 2 Homo sapiens 79-84 11278864-4 2001 The activity of PI3Kalpha in purified human monocytes was evident within 30 s. MCP-1-induced monocyte arrest was significantly inhibited both by wortmannin (n = 4; p < 0.01) and LY294002 (n = 4; p < 0.01) with restoration of the rolling phenotype (p < 0.05 for both inhibitors, compared with rolling of control monocytes after MCP-1 treatment). Wortmannin 145-155 C-C motif chemokine ligand 2 Homo sapiens 336-341 11278864-4 2001 The activity of PI3Kalpha in purified human monocytes was evident within 30 s. MCP-1-induced monocyte arrest was significantly inhibited both by wortmannin (n = 4; p < 0.01) and LY294002 (n = 4; p < 0.01) with restoration of the rolling phenotype (p < 0.05 for both inhibitors, compared with rolling of control monocytes after MCP-1 treatment). 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 181-189 C-C motif chemokine ligand 2 Homo sapiens 79-84 11463608-9 2001 We conclude that MCP-1 is upregulated in the remodeling of pulmonary arteries in close association with increased pulmonary vascular resistance in CTEPH. cteph 147-152 C-C motif chemokine ligand 2 Homo sapiens 17-22 11342529-8 2001 Leptin-induced ROS generation, CPT-1 activation, ACC inhibition, and MCP-1 overproduction were found to be completely prevented by either genistein, a tyrosine kinase inhibitor, H-89, a protein kinase A (PKA) inhibitor, or tetradecylglycidate, a CPT-1 inhibitor. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide 178-182 C-C motif chemokine ligand 2 Homo sapiens 69-74 11428868-5 2001 The induced IL-8 and MCP-1 mRNA and proteins were partially suppressed by U0126, a specific MEK inhibitor, and by SB202190, a selective p38 inhibitor. U 0126 74-79 C-C motif chemokine ligand 2 Homo sapiens 21-26 11342529-8 2001 Leptin-induced ROS generation, CPT-1 activation, ACC inhibition, and MCP-1 overproduction were found to be completely prevented by either genistein, a tyrosine kinase inhibitor, H-89, a protein kinase A (PKA) inhibitor, or tetradecylglycidate, a CPT-1 inhibitor. Genistein 138-147 C-C motif chemokine ligand 2 Homo sapiens 69-74 11512674-0 2001 Hyaluronan fragments induce the synthesis of MCP-1 and IL-8 in cultured human peritoneal mesothelial cells. Hyaluronic Acid 0-10 C-C motif chemokine ligand 2 Homo sapiens 45-50 11512674-2 2001 In this study we investigated the effect of experimentally generated hyaluronan (HA) fragments, degradation products of the extracellular matrix component hyaluronan, which accumulate at inflammatory sites, on the expression of MCP-1 and IL-8 in cultured HMC. Hyaluronic Acid 69-79 C-C motif chemokine ligand 2 Homo sapiens 228-233 11512674-2 2001 In this study we investigated the effect of experimentally generated hyaluronan (HA) fragments, degradation products of the extracellular matrix component hyaluronan, which accumulate at inflammatory sites, on the expression of MCP-1 and IL-8 in cultured HMC. Hyaluronic Acid 155-165 C-C motif chemokine ligand 2 Homo sapiens 228-233 11442523-8 2001 RESULTS: Aortic macrophage influx in response to MCP-1, thioglycollate or C. pneumoniae was more than doubled in the cholesterol-fed animals. Cholesterol 117-128 C-C motif chemokine ligand 2 Homo sapiens 49-54 11442523-12 2001 Application of thioglycollate 0.1 mol/l, or live or formalin-inactivated C. pneumoniae (0.5 x 108 organisms), was associated with a similar increase in macrophages to that caused by MCP-1 and a significant (approximately twofold) increase in aortic diameter after 3 weeks. Thioglycolates 15-29 C-C motif chemokine ligand 2 Homo sapiens 182-187 11428868-5 2001 The induced IL-8 and MCP-1 mRNA and proteins were partially suppressed by U0126, a specific MEK inhibitor, and by SB202190, a selective p38 inhibitor. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 114-122 C-C motif chemokine ligand 2 Homo sapiens 21-26 11449089-14 2001 Estradiol also inhibited the MCP-1 protein production in a concentration-dependent manner (p < 0.05). Estradiol 0-9 C-C motif chemokine ligand 2 Homo sapiens 29-34 11422736-0 2001 High glucose induces MCP-1 expression partly via tyrosine kinase-AP-1 pathway in peritoneal mesothelial cells. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 21-26 11422736-4 2001 However, little is known about the effect of high glucose on MCP-1 expression and its signal transduction pathway in human peritoneal mesothelial cells. Glucose 50-57 C-C motif chemokine ligand 2 Homo sapiens 61-66 11422736-9 2001 RESULTS: Glucose induced MCP-1 mRNA expression in a time- and dose-dependent manner. Glucose 9-16 C-C motif chemokine ligand 2 Homo sapiens 25-30 11422736-12 2001 High-glucose-conditioned supernatant possessed an increased chemotactic activity for monocytes, which was neutralized by anti-MCP-1 antibody. Glucose 5-12 C-C motif chemokine ligand 2 Homo sapiens 126-131 11422736-14 2001 Curcumin, an inhibitor of AP-1, dose-dependently suppressed the induction of MCP-1 mRNA by high glucose. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 77-82 11422736-14 2001 Curcumin, an inhibitor of AP-1, dose-dependently suppressed the induction of MCP-1 mRNA by high glucose. Glucose 96-103 C-C motif chemokine ligand 2 Homo sapiens 77-82 11422736-15 2001 Tyrosine kinase inhibitors such as genistein (12.5 to 50 micromol/L) and herbimycin A (0.1 to 1 micromol/L) inhibited the high-glucose-induced MCP-1 mRNA expression in a dose-dependent manner, and also suppressed the high-glucose-induced AP-1 binding activity. Genistein 35-44 C-C motif chemokine ligand 2 Homo sapiens 143-148 11422736-15 2001 Tyrosine kinase inhibitors such as genistein (12.5 to 50 micromol/L) and herbimycin A (0.1 to 1 micromol/L) inhibited the high-glucose-induced MCP-1 mRNA expression in a dose-dependent manner, and also suppressed the high-glucose-induced AP-1 binding activity. herbimycin 73-85 C-C motif chemokine ligand 2 Homo sapiens 143-148 11422736-15 2001 Tyrosine kinase inhibitors such as genistein (12.5 to 50 micromol/L) and herbimycin A (0.1 to 1 micromol/L) inhibited the high-glucose-induced MCP-1 mRNA expression in a dose-dependent manner, and also suppressed the high-glucose-induced AP-1 binding activity. Glucose 127-134 C-C motif chemokine ligand 2 Homo sapiens 143-148 11422736-15 2001 Tyrosine kinase inhibitors such as genistein (12.5 to 50 micromol/L) and herbimycin A (0.1 to 1 micromol/L) inhibited the high-glucose-induced MCP-1 mRNA expression in a dose-dependent manner, and also suppressed the high-glucose-induced AP-1 binding activity. Glucose 222-229 C-C motif chemokine ligand 2 Homo sapiens 143-148 11422736-16 2001 CONCLUSIONS: : High glucose induced mesothelial MCP-1 expression partly via the tyrosine kinase-AP-1 pathway. Glucose 20-27 C-C motif chemokine ligand 2 Homo sapiens 48-53 11478413-7 2001 Tracheal concentrations of IL-8 and MCP-1 were significantly increased in infants who developed BPD (IL-8: P=0.0001; MCP-1: P<0.001, analysis of variance) and correlated with duration of mechanical ventilation and oxygen treatment. Oxygen 217-223 C-C motif chemokine ligand 2 Homo sapiens 36-41 11455205-0 2001 Monocyte chemotactic protein 1 amplifies serotonin-induced vascular smooth muscle cell proliferation. Serotonin 41-50 C-C motif chemokine ligand 2 Homo sapiens 0-30 11455205-10 2001 Anti-MCP-1 antibody (2 microg/ml) and the Janus kinase 2 (JAK2) inhibitor AG490 (10 microM) significantly inhibited the interaction of MCP-1 with 5-HT. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide 74-79 C-C motif chemokine ligand 2 Homo sapiens 135-140 11455205-11 2001 Further, the amplified mitogenic effect of 5-HT with MCP-1 was completely reversed by the combined use of sarpogrelate with anti-MCP-1 antibody. sarpogrelate 106-118 C-C motif chemokine ligand 2 Homo sapiens 53-58 11371625-5 2001 Doses of the rapidly or slowly dissociating ligands that generated equivalent levels of tyrosine-phosphorylated receptors comparably stimulated a putatively distal event: transcription of the gene for monocyte chemoattractant protein 1. Tyrosine 88-96 C-C motif chemokine ligand 2 Homo sapiens 201-235 11390343-0 2001 Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: implications for vascular disease. Homocysteine 0-12 C-C motif chemokine ligand 2 Homo sapiens 49-83 11390343-3 2001 METHODS AND RESULTS: Northern blot and RNase protection assays showed that DL-homocysteine induced mRNA expression of the proinflammatory cytokines monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in cultured human aortic endothelial cells (HAECs). DL-Homocysteine 75-90 C-C motif chemokine ligand 2 Homo sapiens 148-182 11390343-3 2001 METHODS AND RESULTS: Northern blot and RNase protection assays showed that DL-homocysteine induced mRNA expression of the proinflammatory cytokines monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) in cultured human aortic endothelial cells (HAECs). DL-Homocysteine 75-90 C-C motif chemokine ligand 2 Homo sapiens 184-189 11390343-5 2001 MCP-1 mRNA expression increased 1 hour after homocysteine treatment, reached a maximum within 2 to 4 hours, and declined to basal levels over the next 24 hours. Homocysteine 45-57 C-C motif chemokine ligand 2 Homo sapiens 0-5 11390343-7 2001 Homocysteine also triggered the release of MCP-1 and IL-8 protein from HAECs into the culture medium. Homocysteine 0-12 C-C motif chemokine ligand 2 Homo sapiens 43-48 11390343-12 2001 CONCLUSIONS: Pathophysiological levels of L-homocysteine alter endothelial cell function by upregulating MCP-1 and IL-8 expression and secretion. Homocysteine 42-56 C-C motif chemokine ligand 2 Homo sapiens 105-110 11356643-0 2001 Homocysteine induces monocyte chemoattractant protein-1 expression by activating NF-kappaB in THP-1 macrophages. Homocysteine 0-12 C-C motif chemokine ligand 2 Homo sapiens 21-55 11356643-4 2001 The objective of the present study was to investigate the effect of homocysteine on MCP-1 expression in macrophages and the underlying mechanism of such effect. Homocysteine 68-80 C-C motif chemokine ligand 2 Homo sapiens 84-89 11356643-6 2001 By nuclease protection assay and ELISA, homocysteine (0.05-0.2 mM) was shown to significantly enhance the expression of MCP-1 mRNA (up to 2.6-fold) and protein (up to 4.8-fold) in these cells. Homocysteine 40-52 C-C motif chemokine ligand 2 Homo sapiens 120-125 11356643-7 2001 Homocysteine-induced MCP-1 expression resulted in increased monocyte chemotaxis. Homocysteine 0-12 C-C motif chemokine ligand 2 Homo sapiens 21-26 11356643-8 2001 The increase in MCP-1 expression was associated with activation of nuclear factor (NF)-kappaB due to increased phosphorylation of the inhibitory protein (IkappaB-alpha) as well as reduced expression of IkappaB-alpha mRNA in homocysteine-treated cells. Homocysteine 224-236 C-C motif chemokine ligand 2 Homo sapiens 16-21 11356643-9 2001 In conclusion, our results demonstrate that homocysteine, at pathological concentration, stimulates MCP-1 expression in THP-1 macrophages via NF-kappaB activation. Homocysteine 44-56 C-C motif chemokine ligand 2 Homo sapiens 100-105 11381075-7 2001 Combined inhibition of MEK by U0126, p38 by SB202190, and Janus kinase (jak) by AG490 revealed that GHSA stimulation of IL-8 production was predominately mediated by MEK and to a lesser extent by p38 pathways, whereas activation of MEK, p38, and jak was required for maximal MCP-1 induction. ghsa 100-104 C-C motif chemokine ligand 2 Homo sapiens 275-280 11381075-9 2001 CONCLUSIONS: GHSA stimulates hRPE IL-8 and MCP-1 production through divergent and overlapping, but not identical, intracellular signaling cascades. ghsa 13-17 C-C motif chemokine ligand 2 Homo sapiens 43-48 11398146-6 2001 Finally, treatment of HASMCs with gliclazide resulted in a marked decrease in oxidatively modified LDL-induced monocyte chemoattractant protein (MCP)-1 and human heat shock protein 70 (hsp 70) expression, both at the gene and protein levels. hasmcs 22-28 C-C motif chemokine ligand 2 Homo sapiens 111-151 11404382-5 2001 Simvastatin dose dependently inhibited THP-1 cell migration mediated by monocyte chemoattractant protein 1, with a 50% inhibitory concentration of about 50 nM. Simvastatin 0-11 C-C motif chemokine ligand 2 Homo sapiens 72-106 11398146-6 2001 Finally, treatment of HASMCs with gliclazide resulted in a marked decrease in oxidatively modified LDL-induced monocyte chemoattractant protein (MCP)-1 and human heat shock protein 70 (hsp 70) expression, both at the gene and protein levels. Gliclazide 34-44 C-C motif chemokine ligand 2 Homo sapiens 111-151 11342615-7 2001 In addition, histamine induces a potent production of IL-6, IL-8, monocyte chemoattractant protein 1, and macrophage-inflammatory protein 1alpha by immature DC and also up-regulates IL-1beta, RANTES, and macrophage-inflammatory protein 1beta but not TNF-alpha and IL-12 mRNA expression. Histamine 13-22 C-C motif chemokine ligand 2 Homo sapiens 66-100 11278958-8 2001 Furthermore, we show that decreased monocyte chemotactic activity in HAEC treated with sodium orthovanadate or MKP-1 antisense oligonucleotides is due to decreased MCP-1 protein. Sodium orthovanadate 87-107 C-C motif chemokine ligand 2 Homo sapiens 164-169 11278958-8 2001 Furthermore, we show that decreased monocyte chemotactic activity in HAEC treated with sodium orthovanadate or MKP-1 antisense oligonucleotides is due to decreased MCP-1 protein. Oligonucleotides 127-143 C-C motif chemokine ligand 2 Homo sapiens 164-169 11403209-3 2001 We observed that exposure of human aortic smooth muscle cells to pathophysiologically relevant concentrations of homocysteine results in concentration-dependent increases in cytokine-induced MCP-1 and IL-8 secretion. Homocysteine 113-125 C-C motif chemokine ligand 2 Homo sapiens 191-196 11403209-4 2001 RNase protection assays revealed that both MCP-1 and IL-8 mRNA concentrations are increased in homocysteine-treated smooth muscle cells when compared to cells activated with cytokines alone. Homocysteine 95-107 C-C motif chemokine ligand 2 Homo sapiens 43-48 11403209-6 2001 Cumulatively, these data suggest that homocysteine may increase monocyte recruitment into developing atherosclerotic lesions by upregulating MCP-1 and IL-8 expression in vascular smooth muscle cells. Homocysteine 38-50 C-C motif chemokine ligand 2 Homo sapiens 141-146 11434692-5 2001 Furthermore, thrombin-induced p38 MAP kinase activation as well as MCP-1 expression were impaired by antioxidants as well as by p22phox antisense oligonucleotides. Oligonucleotides 146-162 C-C motif chemokine ligand 2 Homo sapiens 67-72 11382718-7 2001 The effect of CRP on MCP-1 induction was not influenced by aspirin (at concentrations up to 1 mmol/L), but it was significantly inhibited by 5 micromol/L simvastatin. Simvastatin 154-165 C-C motif chemokine ligand 2 Homo sapiens 21-26 11382718-8 2001 The peroxisome proliferator-activated receptor-alpha activators fenofibrate (100 micromol/L) and Wy-14649 (100 micromol/L) almost completely abolished the induction of MCP-1, but the peroxisome proliferator-activated receptor-gamma activator ciglitazone had only a moderate effect. Fenofibrate 64-75 C-C motif chemokine ligand 2 Homo sapiens 168-173 11290562-9 2001 Pretreatment of HPFBs with actinomycin D or puromycin dose-dependently reduced cytokine-stimulated IL-8 and MCP-1 secretion, which suggested de novo chemokine synthesis. hpfbs 16-21 C-C motif chemokine ligand 2 Homo sapiens 108-113 11350939-3 2001 This has functional consequences, as the CCR2 and CCR5 ligands monocyte chemotactic protein-1 (MCP-1) and RANTES (regulated upon activation, normal T cell-expressed and secreted) cooperate to trigger calcium responses at concentrations 10- to 100-fold lower than the threshold for either chemokine alone. Calcium 200-207 C-C motif chemokine ligand 2 Homo sapiens 63-93 11350939-3 2001 This has functional consequences, as the CCR2 and CCR5 ligands monocyte chemotactic protein-1 (MCP-1) and RANTES (regulated upon activation, normal T cell-expressed and secreted) cooperate to trigger calcium responses at concentrations 10- to 100-fold lower than the threshold for either chemokine alone. Calcium 200-207 C-C motif chemokine ligand 2 Homo sapiens 95-100 11311138-4 2001 Pyk2 was tyrosine phosphorylated very quickly after stimulation with MCP-1. Tyrosine 9-17 C-C motif chemokine ligand 2 Homo sapiens 69-74 11311138-5 2001 We found that Lyn, Shc and paxillin were also tyrosine phosphorylated by MCP-1. Tyrosine 46-54 C-C motif chemokine ligand 2 Homo sapiens 73-78 11385283-9 2001 Inhibitors of NF-kappa B activation such as N-acetylcysteine or N-tosyl-L-phenylalanine chloromethyl ketone can suppress Fc epsilon RI-induced TNF-alpha and MCP-1 release. Acetylcysteine 44-60 C-C motif chemokine ligand 2 Homo sapiens 157-162 11385283-9 2001 Inhibitors of NF-kappa B activation such as N-acetylcysteine or N-tosyl-L-phenylalanine chloromethyl ketone can suppress Fc epsilon RI-induced TNF-alpha and MCP-1 release. Tosylphenylalanyl Chloromethyl Ketone 64-107 C-C motif chemokine ligand 2 Homo sapiens 157-162 11336104-0 2001 Doxazosin inhibits monocyte chemotactic protein 1-directed migration of human monocytes. Doxazosin 0-9 C-C motif chemokine ligand 2 Homo sapiens 19-49 11336104-4 2001 The purpose of the present study was to determine the effects of Dox on MCP-1-directed monocyte migration, MMP-9 activity, and TIMP-1 expression. Doxazosin 65-68 C-C motif chemokine ligand 2 Homo sapiens 72-77 11336104-6 2001 Dox inhibited MCP-1-induced migration in a dose-dependent manner, with a maximal reduction at 10 microM of 69.5+/-5.9% in HPBM and 72.2+/-3.2% in THP-1 cells. Doxazosin 0-3 C-C motif chemokine ligand 2 Homo sapiens 14-19 11336104-11 2001 The present study demonstrates a potential novel antiatherosclerotic action of Dox by blocking MCP-1-directed monocyte migration, which might be partly mediated by inhibition of MMP-9 activity. Doxazosin 79-82 C-C motif chemokine ligand 2 Homo sapiens 95-100 11290562-9 2001 Pretreatment of HPFBs with actinomycin D or puromycin dose-dependently reduced cytokine-stimulated IL-8 and MCP-1 secretion, which suggested de novo chemokine synthesis. Dactinomycin 27-40 C-C motif chemokine ligand 2 Homo sapiens 108-113 11290562-9 2001 Pretreatment of HPFBs with actinomycin D or puromycin dose-dependently reduced cytokine-stimulated IL-8 and MCP-1 secretion, which suggested de novo chemokine synthesis. Puromycin 44-53 C-C motif chemokine ligand 2 Homo sapiens 108-113 11238664-5 2001 Both rheumatoid arthritis (RA) and osteoarthritis (OA) FLS and DF spontaneously produced MCP-1 in culture over a similar range of concentrations. CHEMBL1232769 55-58 C-C motif chemokine ligand 2 Homo sapiens 89-94 11275557-7 2001 The synthetic and intramolecularly disulfide-linked peptides of C27 and G25 (sC27 and sG25) also inhibited the chemotaxis induced by MCP-1, while their derivatives with serine in place of cysteine did not, suggesting the importance of the loop structure for the inhibition. Disulfides 35-44 C-C motif chemokine ligand 2 Homo sapiens 133-138 11310855-6 2001 In both cell lines, the enhancement of MCP-1 binding by stimulation with MCP-1 was blocked by cytochalasin D, an inhibitor of actin polymerization. Cytochalasin D 94-108 C-C motif chemokine ligand 2 Homo sapiens 39-44 11310855-6 2001 In both cell lines, the enhancement of MCP-1 binding by stimulation with MCP-1 was blocked by cytochalasin D, an inhibitor of actin polymerization. Cytochalasin D 94-108 C-C motif chemokine ligand 2 Homo sapiens 73-78 11310855-7 2001 This effect of pre-treatment with MCP-1 is insensitive to pertussis toxin and partially blocked by U73122, an inhibitor of phospholipase C. These results demonstrate that the MCP-1 receptor binding affinity is up-regulated by MCP-1 stimuli in an actin polymerization-dependent manner. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 99-105 C-C motif chemokine ligand 2 Homo sapiens 34-39 11310855-7 2001 This effect of pre-treatment with MCP-1 is insensitive to pertussis toxin and partially blocked by U73122, an inhibitor of phospholipase C. These results demonstrate that the MCP-1 receptor binding affinity is up-regulated by MCP-1 stimuli in an actin polymerization-dependent manner. 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione 99-105 C-C motif chemokine ligand 2 Homo sapiens 175-180 11316119-5 2001 Initial plasma MCP-1 antigen levels (mean +/- SE, pg/ml) in the patients with SEA were significantly higher than those in the control group (852.3+/-51.4 vs 418.2+/-26.7, p<0.001). Selenium 46-48 C-C motif chemokine ligand 2 Homo sapiens 15-20 11388697-10 2001 Results show that in vivo ethanol was associated with downregulation of MIP-1alpha and MCP-1 mRNA expression and protein release in primary cultures of Kupffer cells. Ethanol 26-33 C-C motif chemokine ligand 2 Homo sapiens 87-92 11287779-0 2001 Effect of high glucose concentration on the synthesis of monocyte chemoattractant protein-1 in human peritoneal mesothelial cells: involvement of protein kinase C. Human peritoneal mesothelial cells (HMC) contribute to the activation and control of inflammatory processes in the peritoneum by their potential to produce various inflammatory mediators. Glucose 15-22 C-C motif chemokine ligand 2 Homo sapiens 57-91 11287779-1 2001 The present study was designed to assess the effect of glucose, the osmotic active compound in most commercially available peritoneal dialysis fluids, on the synthesis of the C-C chemokine monocyte chemoattractant protein-1 (MCP-1) in cultured HMC. Glucose 55-62 C-C motif chemokine ligand 2 Homo sapiens 189-223 11287779-1 2001 The present study was designed to assess the effect of glucose, the osmotic active compound in most commercially available peritoneal dialysis fluids, on the synthesis of the C-C chemokine monocyte chemoattractant protein-1 (MCP-1) in cultured HMC. Glucose 55-62 C-C motif chemokine ligand 2 Homo sapiens 225-230 11287779-3 2001 Incubation of HMC with glucose (30-120 mM) resulted in a time- and concentration-dependent increase in MCP-1 protein secretion and mRNA expression. Glucose 23-30 C-C motif chemokine ligand 2 Homo sapiens 103-108 11287779-4 2001 After 24 h the MCP-1 synthesis was increased from 2.8 +/- 0.46 to 4.2 +/- 0.32 ng/10(5) cells (n = 5, p < 0.05) in HMC treated with 60 mM glucose. Glucose 141-148 C-C motif chemokine ligand 2 Homo sapiens 15-20 11287779-6 2001 The stimulating effect of high glucose on MCP-1 expression in HMC was mimicked by activation of protein kinase C (PKC) with the phorbol ester PMA (20 nM). Glucose 31-38 C-C motif chemokine ligand 2 Homo sapiens 42-47 11287779-6 2001 The stimulating effect of high glucose on MCP-1 expression in HMC was mimicked by activation of protein kinase C (PKC) with the phorbol ester PMA (20 nM). Phorbol Esters 128-141 C-C motif chemokine ligand 2 Homo sapiens 42-47 11287779-6 2001 The stimulating effect of high glucose on MCP-1 expression in HMC was mimicked by activation of protein kinase C (PKC) with the phorbol ester PMA (20 nM). Tetradecanoylphorbol Acetate 142-145 C-C motif chemokine ligand 2 Homo sapiens 42-47 11287779-7 2001 Coincubation of the cells with glucose and the specific PKC inhibitor Ro 31-8220 completely blunted glucose-mediated MCP-1 expression. Glucose 31-38 C-C motif chemokine ligand 2 Homo sapiens 117-122 11287779-7 2001 Coincubation of the cells with glucose and the specific PKC inhibitor Ro 31-8220 completely blunted glucose-mediated MCP-1 expression. Ro 31-8220 70-80 C-C motif chemokine ligand 2 Homo sapiens 117-122 11287779-7 2001 Coincubation of the cells with glucose and the specific PKC inhibitor Ro 31-8220 completely blunted glucose-mediated MCP-1 expression. Glucose 100-107 C-C motif chemokine ligand 2 Homo sapiens 117-122 11287779-8 2001 In summary, our results indicate that glucose induces MCP-1 synthesis by a PKC-dependent pathway. Glucose 38-45 C-C motif chemokine ligand 2 Homo sapiens 54-59 11230753-4 2001 Pretreatment of HSC with nonspecific COX inhibitors such as indomethacin or ibuprofen markedly reduced the expression of MCP-1 caused by exposure to tumor necrosis factor alpha (TNF-alpha) or interleukin-1alpha (IL-1alpha). Indomethacin 60-72 C-C motif chemokine ligand 2 Homo sapiens 121-126 11230753-9 2001 Pretreatment of HSC with the stable cyclic adenosine monophosphate (cAMP) analog, 8-bromo cAMP, reverted the effects of the COX-2 inhibitor, but not of a nuclear factor-kappaB (NF-kappaB) inhibitor, demonstrating that prostaglandins modulate MCP-1 expression via production of cAMP. Cyclic AMP 90-94 C-C motif chemokine ligand 2 Homo sapiens 242-247 11231910-14 2001 MCP-1 may induce luminal renarrowing, at least in part, by inducing O(2)(-) release in monocytes. o(2) 68-72 C-C motif chemokine ligand 2 Homo sapiens 0-5 11230753-4 2001 Pretreatment of HSC with nonspecific COX inhibitors such as indomethacin or ibuprofen markedly reduced the expression of MCP-1 caused by exposure to tumor necrosis factor alpha (TNF-alpha) or interleukin-1alpha (IL-1alpha). Ibuprofen 76-85 C-C motif chemokine ligand 2 Homo sapiens 121-126 11230753-5 2001 NS-398, a specific COX-2 inhibitor, also resulted in a dose-dependent inhibition of MCP-1 gene and protein expression. N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide 0-6 C-C motif chemokine ligand 2 Homo sapiens 84-89 11230753-9 2001 Pretreatment of HSC with the stable cyclic adenosine monophosphate (cAMP) analog, 8-bromo cAMP, reverted the effects of the COX-2 inhibitor, but not of a nuclear factor-kappaB (NF-kappaB) inhibitor, demonstrating that prostaglandins modulate MCP-1 expression via production of cAMP. Cyclic AMP 68-72 C-C motif chemokine ligand 2 Homo sapiens 242-247 11230753-9 2001 Pretreatment of HSC with the stable cyclic adenosine monophosphate (cAMP) analog, 8-bromo cAMP, reverted the effects of the COX-2 inhibitor, but not of a nuclear factor-kappaB (NF-kappaB) inhibitor, demonstrating that prostaglandins modulate MCP-1 expression via production of cAMP. 8-Bromo Cyclic Adenosine Monophosphate 82-94 C-C motif chemokine ligand 2 Homo sapiens 242-247 11730565-4 2001 RESULTS: AGEP-BSA stimulated monocytes to express MCP-1 mRNA in a glucose-concentration-related fashion. Glucose 66-73 C-C motif chemokine ligand 2 Homo sapiens 50-55 11330569-11 2001 Moreover, treatment with H-PDF impaired the release of MCP-1 from HPMC to a significantly greater degree compared to F-PDF (17.4% and 24.9% difference for low and high glucose PDF, respectively). hydroxypropylmethylcellulose-lactose matrix 66-70 C-C motif chemokine ligand 2 Homo sapiens 55-60 11330569-12 2001 CONCLUSIONS: Exposure of HPMC to H-PDF significantly impairs cell viability and the capacity for generating MCP-1 compared to F-PDF. hydroxypropylmethylcellulose-lactose matrix 25-29 C-C motif chemokine ligand 2 Homo sapiens 108-113 11330569-12 2001 CONCLUSIONS: Exposure of HPMC to H-PDF significantly impairs cell viability and the capacity for generating MCP-1 compared to F-PDF. h-pdf 33-38 C-C motif chemokine ligand 2 Homo sapiens 108-113 11216879-0 2001 Comparative effect of danazol and a GnRH agonist on monocyte chemotactic protein-1 expression by endometriotic cells. Danazol 22-29 C-C motif chemokine ligand 2 Homo sapiens 52-82 11216879-6 2001 RESULTS: Our results show that danazol concentrations (10(-7) -10(-5) M), taking into account the therapeutic levels found in the plasma of treated patients, inhibited MCP-1 protein and mRNA steady-state levels in endometriotic cells, whereas buserelin acetate (0.1-10 ng/mL), a GnRH agonist, had no significant effect. Danazol 31-38 C-C motif chemokine ligand 2 Homo sapiens 168-173 11216879-8 2001 CONCLUSIONS: These results put into prominence the capability of danazol to directly inhibit the expression of a potent monocyte chemotactic and activating factor by ectopic endometrial cells shedding more light on the mechanisms underlying the clinical effects of hormonal therapeutic agents used in the treatment of endometriosis. Danazol 65-72 C-C motif chemokine ligand 2 Homo sapiens 120-162 11219668-16 2001 Additionally, specific pathways to (di)chloroaromatics and chlorinated fulvene-type structures are outlined via CHCl2 and CCl2 radicals. (di)chloroaromatics 35-54 C-C motif chemokine ligand 2 Homo sapiens 122-126 11216967-8 2001 4) Monocyte chemoattractant protein-1 enhanced the generation of O2- in monocytes from unstable angina patients, and the antioxidant glutathione-monoethyl ester suppressed the production of IL-8 and MCP-1 in these cells. Oxygen 65-67 C-C motif chemokine ligand 2 Homo sapiens 3-37 11154209-8 2001 Furthermore, MCP-1-mediated chemotaxis and transendothelial migration were significantly diminished by a high concentration of SB202190, a broad SAPK inhibitor, or by SB203580, a specific inhibitor of SAPK2/p38, and abolished by pertussis toxin treatment. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 127-135 C-C motif chemokine ligand 2 Homo sapiens 13-18 11154209-8 2001 Furthermore, MCP-1-mediated chemotaxis and transendothelial migration were significantly diminished by a high concentration of SB202190, a broad SAPK inhibitor, or by SB203580, a specific inhibitor of SAPK2/p38, and abolished by pertussis toxin treatment. SB 203580 167-175 C-C motif chemokine ligand 2 Homo sapiens 13-18 11730565-5 2001 The levels of MCP-1 mRNA were increased slightly when monocytes were exposed to AGEP-BSA 200 mg/L (glycosylated with glucose 20 mmol/L), and increased markedly when exposed to AGEP-BSA 200 mg/L (glycosylated with glucose 50 mmol/L), but decreased slightly when exposed to AGEP-BSA 200 mg/L (glycosylated with glucose 80 mmol/L). Glucose 117-124 C-C motif chemokine ligand 2 Homo sapiens 14-19 11730565-5 2001 The levels of MCP-1 mRNA were increased slightly when monocytes were exposed to AGEP-BSA 200 mg/L (glycosylated with glucose 20 mmol/L), and increased markedly when exposed to AGEP-BSA 200 mg/L (glycosylated with glucose 50 mmol/L), but decreased slightly when exposed to AGEP-BSA 200 mg/L (glycosylated with glucose 80 mmol/L). Glucose 213-220 C-C motif chemokine ligand 2 Homo sapiens 14-19 11730565-5 2001 The levels of MCP-1 mRNA were increased slightly when monocytes were exposed to AGEP-BSA 200 mg/L (glycosylated with glucose 20 mmol/L), and increased markedly when exposed to AGEP-BSA 200 mg/L (glycosylated with glucose 50 mmol/L), but decreased slightly when exposed to AGEP-BSA 200 mg/L (glycosylated with glucose 80 mmol/L). Glucose 213-220 C-C motif chemokine ligand 2 Homo sapiens 14-19 11121811-5 2001 Platelet-induced secretion of MCP-1 and monocyte-endothelium adhesion was reduced by the MAP kinase p38-specific inhibitor SB203580, but not by other kinase inhibitors including PD98059, wortmannin, or rapamycin. SB 203580 123-131 C-C motif chemokine ligand 2 Homo sapiens 30-35 11133741-4 2001 Both NiCl(2)- and TNFalpha-induced MCP-1 synthesis was sensitive to D609, an inhibitor of phosphatidylcholine-dependent phospholipase C (PC-PLC). tricyclodecane-9-yl-xanthogenate 68-72 C-C motif chemokine ligand 2 Homo sapiens 35-40 11133741-4 2001 Both NiCl(2)- and TNFalpha-induced MCP-1 synthesis was sensitive to D609, an inhibitor of phosphatidylcholine-dependent phospholipase C (PC-PLC). Phosphatidylcholines 90-109 C-C motif chemokine ligand 2 Homo sapiens 35-40 11133741-5 2001 NiCl(2)-induced MCP-1 synthesis required activation of NF-kappaB since mutation of NF-kappaB-binding sites in the promoter resulted in complete loss of inducible promoter activity. nickel chloride 0-7 C-C motif chemokine ligand 2 Homo sapiens 16-21 11211941-7 2001 The production of M-CSF was markedly increased over the basal level after treatment with forskolin (10 microM) for 24 (P < 0.02) and 48 hr (P < 0.01); however, the production of MCP-1 was unchanged. Colforsin 89-98 C-C motif chemokine ligand 2 Homo sapiens 184-189 11121811-5 2001 Platelet-induced secretion of MCP-1 and monocyte-endothelium adhesion was reduced by the MAP kinase p38-specific inhibitor SB203580, but not by other kinase inhibitors including PD98059, wortmannin, or rapamycin. Sirolimus 202-211 C-C motif chemokine ligand 2 Homo sapiens 30-35 11121811-6 2001 In addition, activated platelets induced transcription of a luciferase reporter construct containing a MCP-1 promotor, an effect that could be inhibited by SB203580. SB 203580 156-164 C-C motif chemokine ligand 2 Homo sapiens 103-108 11340307-0 2001 1,25-dihydroxyvitamin D3 differentially regulates IL-1alpha-stimulated IL-8 and MCP-1 mRNA expression and chemokine secretion by human primary proximal tubular epithelial cells. Calcitriol 0-24 C-C motif chemokine ligand 2 Homo sapiens 80-85 11340307-9 2001 After 72 h, 1,25-D3 enhanced the IL-1alpha-stimulated MCP-1 secretion. 1,25-d3 12-19 C-C motif chemokine ligand 2 Homo sapiens 54-59 11127475-11 2000 Asymmetric dimethylarginine-induced monocyte binding was diminished by L-arginine or by a neutralizing anti-MCP-1 antibody. dimethylarginine 11-27 C-C motif chemokine ligand 2 Homo sapiens 108-113 11134659-4 2000 In parallel, exposure of non-stimulated monocytes to various doses of pravastatin resulted in inhibition of monocyte chemoattractant protein-1 protein expression (up to 15-fold), reduction of tumour necrosis factor alpha (TNF-alpha) levels (up to 2.4-fold) and a total loss of metalloproteinase-9 activity in stimulated cells. Pravastatin 70-81 C-C motif chemokine ligand 2 Homo sapiens 108-142 11838000-3 2001 In two independent studies, we demonstrated that mRNA levels for PDGF-A and -B and for MCP-1 are reduced after ingestion of n-3 fatty acids by human volunteers. Fatty Acids, Omega-3 124-139 C-C motif chemokine ligand 2 Homo sapiens 87-92 11104691-0 2000 Homocysteine stimulates nuclear factor kappaB activity and monocyte chemoattractant protein-1 expression in vascular smooth-muscle cells: a possible role for protein kinase C. Monocyte chemoattractant protein-1 (MCP-1) is a potent chemokine that stimulates the migration of monocytes into the intima of arterial walls. Homocysteine 0-12 C-C motif chemokine ligand 2 Homo sapiens 59-93 11104691-0 2000 Homocysteine stimulates nuclear factor kappaB activity and monocyte chemoattractant protein-1 expression in vascular smooth-muscle cells: a possible role for protein kinase C. Monocyte chemoattractant protein-1 (MCP-1) is a potent chemokine that stimulates the migration of monocytes into the intima of arterial walls. Homocysteine 0-12 C-C motif chemokine ligand 2 Homo sapiens 176-210 11104691-0 2000 Homocysteine stimulates nuclear factor kappaB activity and monocyte chemoattractant protein-1 expression in vascular smooth-muscle cells: a possible role for protein kinase C. Monocyte chemoattractant protein-1 (MCP-1) is a potent chemokine that stimulates the migration of monocytes into the intima of arterial walls. Homocysteine 0-12 C-C motif chemokine ligand 2 Homo sapiens 212-217 11104691-1 2000 Although many factors that induce MCP-1 expression have been identified, the effect of homocysteine on the expression of MCP-1 in atherogenesis and the underlying mechanisms are not entirely clear. Homocysteine 87-99 C-C motif chemokine ligand 2 Homo sapiens 121-126 11104691-2 2000 The objective of the present study was to investigate the role of homocysteine in MCP-1 expression in human aorta vascular smooth-muscle cells (VSMCs). Homocysteine 66-78 C-C motif chemokine ligand 2 Homo sapiens 82-87 11104691-4 2000 Homocysteine (0.05-0.2 mM) significantly increased the expression of MCP-1 mRNA (up to 2. Homocysteine 0-12 C-C motif chemokine ligand 2 Homo sapiens 69-74 11104691-9 2000 In conclusion, the present study has clearly demonstrated that the activation of PKC as well as superoxide production followed by activation of NF-kappaB is responsible for homocysteine-induced MCP-1 expression in VSMCs. Superoxides 96-106 C-C motif chemokine ligand 2 Homo sapiens 194-199 11104691-9 2000 In conclusion, the present study has clearly demonstrated that the activation of PKC as well as superoxide production followed by activation of NF-kappaB is responsible for homocysteine-induced MCP-1 expression in VSMCs. Homocysteine 173-185 C-C motif chemokine ligand 2 Homo sapiens 194-199 11104691-10 2000 These results suggest that homocysteine-stimulated MCP-1 expression via NF-kappaB activation may play an important role in atherogenesis. Homocysteine 27-39 C-C motif chemokine ligand 2 Homo sapiens 51-56 11128050-12 2000 DMTU and TMTU attenuated (P < 0.001) the MC + IgGAg-induced migration of Mphi as well as IgGAg-induced mRNA expression for RANTES and MCP-1. 1,3-dimethylthiourea 0-4 C-C motif chemokine ligand 2 Homo sapiens 137-142 11128050-12 2000 DMTU and TMTU attenuated (P < 0.001) the MC + IgGAg-induced migration of Mphi as well as IgGAg-induced mRNA expression for RANTES and MCP-1. tetramethylthiourea 9-13 C-C motif chemokine ligand 2 Homo sapiens 137-142 11086093-4 2000 In this report, we show that [D-Ala(2),N:-Me-Phe(4),Gly-ol(5)]enkephalin (DAMGO), a mu-opioid-selective agonist, augments the expression in human PBMCs of MCP-1, RANTES, and IP-10 at both the mRNA and protein levels. n:-me-phe 39-48 C-C motif chemokine ligand 2 Homo sapiens 155-160 11086093-4 2000 In this report, we show that [D-Ala(2),N:-Me-Phe(4),Gly-ol(5)]enkephalin (DAMGO), a mu-opioid-selective agonist, augments the expression in human PBMCs of MCP-1, RANTES, and IP-10 at both the mRNA and protein levels. gly-ol 52-58 C-C motif chemokine ligand 2 Homo sapiens 155-160 11093125-4 2000 The results show that MCP-1 directly stimulates the elimination of intracellular Leishmania parasites by human monocytes, a potential that correlates with the induction of reactive oxygen intermediates. reactive oxygen 172-187 C-C motif chemokine ligand 2 Homo sapiens 22-27 11053056-6 2000 Furthermore, treatment with either PD098059, SB203580, or the JNK-AP-1 inhibitor curcumin diminished the expression of MCP-1 and stromelysin. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 35-43 C-C motif chemokine ligand 2 Homo sapiens 119-124 11053056-6 2000 Furthermore, treatment with either PD098059, SB203580, or the JNK-AP-1 inhibitor curcumin diminished the expression of MCP-1 and stromelysin. SB 203580 45-53 C-C motif chemokine ligand 2 Homo sapiens 119-124 11053056-6 2000 Furthermore, treatment with either PD098059, SB203580, or the JNK-AP-1 inhibitor curcumin diminished the expression of MCP-1 and stromelysin. Curcumin 81-89 C-C motif chemokine ligand 2 Homo sapiens 119-124 11093800-9 2000 In SH-SY5Y cells, ethanol also decreased mRNA and secreted protein levels for monocyte chemotactic protein 1, an effect that could contribute to the protective role of moderate ethanol consumption in atherosclerotic vascular disease. Ethanol 18-25 C-C motif chemokine ligand 2 Homo sapiens 78-108 11093800-9 2000 In SH-SY5Y cells, ethanol also decreased mRNA and secreted protein levels for monocyte chemotactic protein 1, an effect that could contribute to the protective role of moderate ethanol consumption in atherosclerotic vascular disease. Ethanol 177-184 C-C motif chemokine ligand 2 Homo sapiens 78-108 10979935-4 2000 The present study demonstrates that amphotericin B increases mRNA for the chemokines interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1beta, as well as the cell adhesion molecules intercellular adhesion molecule (ICAM)-1 and CD44 in the human monocytic cell line THP-1. Amphotericin B 36-50 C-C motif chemokine ligand 2 Homo sapiens 105-145 11056242-1 2000 OBJECTIVE: To assess whether hormonal agents used in the medical treatment of endometriosis, such as danazol and GnRH agonist, exert direct regulatory action on monocyte chemotactic protein-1 (MCP-1) expression by endometrial epithelial cells. Danazol 101-108 C-C motif chemokine ligand 2 Homo sapiens 161-191 11056242-1 2000 OBJECTIVE: To assess whether hormonal agents used in the medical treatment of endometriosis, such as danazol and GnRH agonist, exert direct regulatory action on monocyte chemotactic protein-1 (MCP-1) expression by endometrial epithelial cells. Danazol 101-108 C-C motif chemokine ligand 2 Homo sapiens 193-198 11031216-9 2000 Actinomycin D inhibited the release of IL-8 and MCP-1 induced by LDL(-) and oxLDL by up to 80%, indicating that their production is mediated by protein synthesis. Dactinomycin 0-13 C-C motif chemokine ligand 2 Homo sapiens 48-53 11031216-10 2000 Incubation of ECs with N:-acetyl cysteine inhibited production of IL-8 and MCP-1 induced by LDL(-) and oxLDL by >50%. Acetylcysteine 23-41 C-C motif chemokine ligand 2 Homo sapiens 75-80 10979935-5 2000 Amphotericin B increased the concentrations of IL-8, MCP-1, and MIP-1beta in a dose-dependent fashion. Amphotericin B 0-14 C-C motif chemokine ligand 2 Homo sapiens 53-58 10880077-0 2000 G-protein activity requirement for polymethylmethacrylate and titanium particle-induced fibroblast interleukin-6 and monocyte chemoattractant protein-1 release in vitro. Polymethyl Methacrylate 35-57 C-C motif chemokine ligand 2 Homo sapiens 117-151 10982368-9 2000 Tat(72aa)-mediated MCP-1 and IL-8 mRNA induction was susceptible to inhibition by the MEK1/2 inhibitor UO126 but was only modestly decreased by the inclusion of the p38 mitogen-activated protein kinase (MAPK) inhibitor SB202190. U 0126 103-108 C-C motif chemokine ligand 2 Homo sapiens 19-24 10982368-9 2000 Tat(72aa)-mediated MCP-1 and IL-8 mRNA induction was susceptible to inhibition by the MEK1/2 inhibitor UO126 but was only modestly decreased by the inclusion of the p38 mitogen-activated protein kinase (MAPK) inhibitor SB202190. 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole 219-227 C-C motif chemokine ligand 2 Homo sapiens 19-24 11027549-5 2000 In HUVECs, wortmannin, a PI3-kinase inhibitor, inhibits TNF-alpha-mediated MCP-1 secretion at a dose-dependent manner. Wortmannin 11-21 C-C motif chemokine ligand 2 Homo sapiens 75-80 10988245-0 2000 Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipid-induced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells. Phospholipids 70-82 C-C motif chemokine ligand 2 Homo sapiens 104-134 10988245-3 2000 In the present study, we demonstrate that MM-LDL and oxidation products of 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine (PAPC) activate endothelial cells to synthesize monocyte chemotactic protein-1 (MCP-1) and interleukin-8 (IL-8). PC(16:0/20:0) 75-128 C-C motif chemokine ligand 2 Homo sapiens 177-207 10988245-3 2000 In the present study, we demonstrate that MM-LDL and oxidation products of 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine (PAPC) activate endothelial cells to synthesize monocyte chemotactic protein-1 (MCP-1) and interleukin-8 (IL-8). PC(16:0/20:0) 75-128 C-C motif chemokine ligand 2 Homo sapiens 209-214 10988245-3 2000 In the present study, we demonstrate that MM-LDL and oxidation products of 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine (PAPC) activate endothelial cells to synthesize monocyte chemotactic protein-1 (MCP-1) and interleukin-8 (IL-8). PAPC 130-134 C-C motif chemokine ligand 2 Homo sapiens 177-207 10988245-3 2000 In the present study, we demonstrate that MM-LDL and oxidation products of 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine (PAPC) activate endothelial cells to synthesize monocyte chemotactic protein-1 (MCP-1) and interleukin-8 (IL-8). PAPC 130-134 C-C motif chemokine ligand 2 Homo sapiens 209-214 10988245-7 2000 By contrast, troglitazone, a PPARgamma agonist, decreased the levels of IL-8 and MCP-1. Troglitazone 13-25 C-C motif chemokine ligand 2 Homo sapiens 81-86 11006087-6 2000 PDTC concomitantly increased the intracellular levels of copper, and bathocuproinedisulfonic acid, a non-cell-permeable chelator of Cu(1+), inhibited the PDTC-induced increase in intracellular copper level and reversed the PDTC effects on IkappaB-alpha, NF-kappaB, and MCP-1. bathocuproine sulfonate 69-97 C-C motif chemokine ligand 2 Homo sapiens 269-274 11006087-6 2000 PDTC concomitantly increased the intracellular levels of copper, and bathocuproinedisulfonic acid, a non-cell-permeable chelator of Cu(1+), inhibited the PDTC-induced increase in intracellular copper level and reversed the PDTC effects on IkappaB-alpha, NF-kappaB, and MCP-1. Copper 132-134 C-C motif chemokine ligand 2 Homo sapiens 269-274 11006087-7 2000 These results indicate that TNF-alpha-dependent expression of MCP-1 in HASMC is tightly regulated by NF-kappaB and that intracellular copper level is crucial for the TNF-alpha-dependent activation of NF-kappaB in HASMC. Copper 134-140 C-C motif chemokine ligand 2 Homo sapiens 62-67 10880077-13 2000 Pretreatment of fibroblasts with pertussis toxin inhibited the release of interleukin-6 and MCP-1 from PMMA and titanium particle challenged fibroblasts in a dose-dependent manner. Polymethyl Methacrylate 103-107 C-C motif chemokine ligand 2 Homo sapiens 92-97 10880077-13 2000 Pretreatment of fibroblasts with pertussis toxin inhibited the release of interleukin-6 and MCP-1 from PMMA and titanium particle challenged fibroblasts in a dose-dependent manner. Titanium 112-120 C-C motif chemokine ligand 2 Homo sapiens 92-97 10880077-16 2000 PMMA particle-induced fibroblast MCP-1 release was inhibited by 36.0%, 50.4%, and 60.1% with 2-, 20- and 200-ng/mL doses of pertussis toxin, respectively. Polymethyl Methacrylate 0-4 C-C motif chemokine ligand 2 Homo sapiens 33-38 10880077-17 2000 Titanium particle-induced fibroblast MCP-1 release was inhibited by 15.5%, 53.2%, and 64.6% with 2-, 20-, and 200-ng/mL doses of pertussis toxin, respectively. Titanium 0-8 C-C motif chemokine ligand 2 Homo sapiens 37-42 10880077-0 2000 G-protein activity requirement for polymethylmethacrylate and titanium particle-induced fibroblast interleukin-6 and monocyte chemoattractant protein-1 release in vitro. Titanium 62-70 C-C motif chemokine ligand 2 Homo sapiens 117-151 10880077-7 2000 Exposure of fibroblasts to titanium and polymethylmethacrylate (PMMA) particles resulted in a dose-dependent release of MCP-1 and IL-6. Titanium 27-35 C-C motif chemokine ligand 2 Homo sapiens 120-125 10880077-7 2000 Exposure of fibroblasts to titanium and polymethylmethacrylate (PMMA) particles resulted in a dose-dependent release of MCP-1 and IL-6. Polymethyl Methacrylate 40-62 C-C motif chemokine ligand 2 Homo sapiens 120-125 10880077-7 2000 Exposure of fibroblasts to titanium and polymethylmethacrylate (PMMA) particles resulted in a dose-dependent release of MCP-1 and IL-6. Polymethyl Methacrylate 64-68 C-C motif chemokine ligand 2 Homo sapiens 120-125 10936484-4 2000 PPARgamma ligands attenuated MCP-1-induced migration, with 50% inhibition (IC(50)) at 2.8 microM for troglitazone and 4.8 microM for rosiglitazone. Troglitazone 101-113 C-C motif chemokine ligand 2 Homo sapiens 29-34 10984371-9 2000 RESULTS: Calcium influx was induced by monocyte chemotactic protein (MCP) 1, MCP-3, MCP-4, RANTES, eotaxin, IL-8, and stromal cell-derived factor 1alpha, which are chemokines that bind several chemokine receptors. Calcium 9-16 C-C motif chemokine ligand 2 Homo sapiens 39-75 10770925-5 2000 The compounds are effective blockers of MCP-1-driven inhibition of adenylate cyclase and MCP-1- and MCP-3-driven cytosolic calcium influx; the compounds are not agonists for these pathways. Calcium 123-130 C-C motif chemokine ligand 2 Homo sapiens 40-45 10770925-5 2000 The compounds are effective blockers of MCP-1-driven inhibition of adenylate cyclase and MCP-1- and MCP-3-driven cytosolic calcium influx; the compounds are not agonists for these pathways. Calcium 123-130 C-C motif chemokine ligand 2 Homo sapiens 89-94 10936484-4 2000 PPARgamma ligands attenuated MCP-1-induced migration, with 50% inhibition (IC(50)) at 2.8 microM for troglitazone and 4.8 microM for rosiglitazone. Rosiglitazone 133-146 C-C motif chemokine ligand 2 Homo sapiens 29-34 10955814-10 2000 The level of MCP-1 was associated significantly with TAM accumulation. tam 53-56 C-C motif chemokine ligand 2 Homo sapiens 13-18 10966058-9 2000 From our data we conclude that RANTES and MCP-1 induction by silica may be an initiating event in inflammatory infiltration, whereas TNFalpha-mediated inflammation may propagate the disease more efficiently. Silicon Dioxide 61-67 C-C motif chemokine ligand 2 Homo sapiens 42-47 10903760-9 2000 In vitro exposure of primary cultures of murine lung fibroblasts to a NO donor, hydroxylamine, induced a dose-dependent release of macrophage inflammatory protein-2 and monocyte chemoattractant protein-1. Hydroxylamine 80-93 C-C motif chemokine ligand 2 Homo sapiens 169-203 10916091-6 2000 Next, using cultured human mesangial cells, we investigated the role of Gly-Alb and/or HG on the gene and protein expression of MCP-1. Glycine 72-75 C-C motif chemokine ligand 2 Homo sapiens 128-133 10802155-6 2000 Therefore, we investigated the effect of troglitazone on the expression of MCP-1 in human umbilical vein endothelial cells (HUVECs). Troglitazone 41-53 C-C motif chemokine ligand 2 Homo sapiens 75-80 10908155-4 2000 Lovastatin and simvastatin caused a dose-dependent inhibition of MCP-1 production in peripheral blood mononuclear cells exposed to lipopolysaccharide or inactivated Streptococcus hemoliticus and in human endothelial cells exposed to interleukin-1beta. Lovastatin 0-10 C-C motif chemokine ligand 2 Homo sapiens 65-70 10908155-4 2000 Lovastatin and simvastatin caused a dose-dependent inhibition of MCP-1 production in peripheral blood mononuclear cells exposed to lipopolysaccharide or inactivated Streptococcus hemoliticus and in human endothelial cells exposed to interleukin-1beta. Simvastatin 15-26 C-C motif chemokine ligand 2 Homo sapiens 65-70 10871649-3 2000 To elucidate the mechanisms involved in the regulation of MCP-1 expression in eutopic endometrial cells, we studied the effects of ovarian hormones and found that oestradiol (10(-9) and 10(-8) mol/l) markedly increased MCP-1 mRNA steady-state levels and protein secretion by endometrial cells in response to interleukin-1beta (IL-1beta) (0.1 ng/ml). Estradiol 163-173 C-C motif chemokine ligand 2 Homo sapiens 58-63 10871649-4 2000 The IL-1beta-induced MCP-1 expression was even higher following pretreatment of cells with both oestradiol (10(-9) mol/l) and progesterone (5x10(-8) mol/l). Estradiol 96-106 C-C motif chemokine ligand 2 Homo sapiens 21-26 10871649-4 2000 The IL-1beta-induced MCP-1 expression was even higher following pretreatment of cells with both oestradiol (10(-9) mol/l) and progesterone (5x10(-8) mol/l). Progesterone 126-138 C-C motif chemokine ligand 2 Homo sapiens 21-26 10905555-2 2000 We designed and characterized five antisense phosphorothioate oligodeoxynucleotides (PS-ODN) targeting MCP-1 secretion by human pulmonary artery endothelial cells (HPAEC) and pulmonary microvascular endothelial cells (HMVEC-L). phosphorothioate oligodeoxynucleotides 45-83 C-C motif chemokine ligand 2 Homo sapiens 103-108 10905555-2 2000 We designed and characterized five antisense phosphorothioate oligodeoxynucleotides (PS-ODN) targeting MCP-1 secretion by human pulmonary artery endothelial cells (HPAEC) and pulmonary microvascular endothelial cells (HMVEC-L). ps-odn 85-91 C-C motif chemokine ligand 2 Homo sapiens 103-108 10905555-8 2000 We conclude that nanomolar concentrations of specific antisense oligodeoxynucleotides effectively inhibit human endothelial MCP-1 synthesis and may thus provide a rational approach to modulate monocyte recruitment under inflammatory conditions. Oligodeoxyribonucleotides 64-85 C-C motif chemokine ligand 2 Homo sapiens 124-129 10802155-8 2000 We found that TNF-alpha increased the secretions of MCP-1 119-fold vs. control, and that troglitazone significantly inhibited this TNF-alpha-induced increase in MCP-1 secretions (19.4%). Troglitazone 89-101 C-C motif chemokine ligand 2 Homo sapiens 161-166 10802155-9 2000 Moreover, Northern blot analysis revealed that troglitazone decreased the MCP-1 mRNA level in HUVECs. Troglitazone 47-59 C-C motif chemokine ligand 2 Homo sapiens 74-79 10820165-11 2000 Interestingly, thrombin-induced DNA synthesis and MCP-1 gene expression were completely blocked by genistein, a specific tyrosine kinase inhibitor, but not by its inactive analogue daidzein, demonstrating a central role for tyrosine kinase activation in the thrombin effects on hPTC. Genistein 99-108 C-C motif chemokine ligand 2 Homo sapiens 50-55 10857861-5 2000 When titrated, L-790,070 inhibited MCP-1-induced chemotaxis in a concentration-dependent manner with an IC50 of 0.3 nM. l 15-16 C-C motif chemokine ligand 2 Homo sapiens 35-40 10825372-9 2000 Secretion of monocyte chemotactic protein (MCP-1) was significantly (P < 0.05) increased from biopsies taken 6-24 h after mifepristone administration. Mifepristone 125-137 C-C motif chemokine ligand 2 Homo sapiens 43-48 10669634-8 2000 However, simultaneous blockade of the ERK1/2 and ROS pathways by using PD098059 combined with diphenylene iodonium or N-acetylcysteine potently enhanced the ability of MAPK kinase inhibitors to abrogate MCP-1 mRNA expression (100+/-2% inhibition). Reactive Oxygen Species 49-52 C-C motif chemokine ligand 2 Homo sapiens 203-208 10769273-12 2000 Coincubation with cerivastatin resulted in significantly lower MCP-1 and IL-8 production, whereas the release of TNF-alpha remained unaffected. cerivastatin 18-30 C-C motif chemokine ligand 2 Homo sapiens 63-68 10657660-0 2000 Selective inhibition of monocyte chemoattractant protein-1 gene expression in human embryonal kidney cells by specific triple helix-forming oligonucleotides. triple 119-125 C-C motif chemokine ligand 2 Homo sapiens 24-58 10657660-0 2000 Selective inhibition of monocyte chemoattractant protein-1 gene expression in human embryonal kidney cells by specific triple helix-forming oligonucleotides. helix-forming oligonucleotides 126-156 C-C motif chemokine ligand 2 Homo sapiens 24-58 10657660-4 2000 In the present study, our aim was to test whether the MCP-1 expression could be inhibited at the transcriptional level using triple helix-forming oligonucleotides (TFOs). triple helix-forming oligonucleotides 125-162 C-C motif chemokine ligand 2 Homo sapiens 54-59 10657660-4 2000 In the present study, our aim was to test whether the MCP-1 expression could be inhibited at the transcriptional level using triple helix-forming oligonucleotides (TFOs). tfos 164-168 C-C motif chemokine ligand 2 Homo sapiens 54-59 10657660-5 2000 We designed a TFO targeted to the SP-1 binding site in the human MCP-1 gene promoter. tfo 14-17 C-C motif chemokine ligand 2 Homo sapiens 65-70 10657660-8 2000 The TFO could also partially inhibit endogenous MCP-1 gene expression in cultured human embryonic kidney cells. tfo 4-7 C-C motif chemokine ligand 2 Homo sapiens 48-53 10657660-9 2000 Treatment of TNF-alpha-stimulated human embryonic kidney 293 cells with the TFO inhibited the secretion of MCP-1 in a dose-dependent manner (up to 45% at 5 microM oligonucleotide). tfo 76-79 C-C motif chemokine ligand 2 Homo sapiens 107-112 10657660-9 2000 Treatment of TNF-alpha-stimulated human embryonic kidney 293 cells with the TFO inhibited the secretion of MCP-1 in a dose-dependent manner (up to 45% at 5 microM oligonucleotide). Oligonucleotides 163-178 C-C motif chemokine ligand 2 Homo sapiens 107-112 10657660-10 2000 The inhibition of MCP secretion was caused at the level of gene transcription, because MCP-1 mRNA levels in oligonucleotide-treated cells were also decreased by approximately 40%. Oligonucleotides 108-123 C-C motif chemokine ligand 2 Homo sapiens 87-92 10720473-4 2000 The induction of MCP-1 by GA was dose-dependent. Gallium 26-28 C-C motif chemokine ligand 2 Homo sapiens 17-22 10720473-5 2000 The MCP-1 mRNA expression by GA was completely inhibited by PD98059 and genistein that inhibit mitogen activated protein (MAP) kinase kinase and tyrosine kinase, respectively. Gallium 29-31 C-C motif chemokine ligand 2 Homo sapiens 4-9 10720473-5 2000 The MCP-1 mRNA expression by GA was completely inhibited by PD98059 and genistein that inhibit mitogen activated protein (MAP) kinase kinase and tyrosine kinase, respectively. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 60-67 C-C motif chemokine ligand 2 Homo sapiens 4-9 10720473-5 2000 The MCP-1 mRNA expression by GA was completely inhibited by PD98059 and genistein that inhibit mitogen activated protein (MAP) kinase kinase and tyrosine kinase, respectively. Genistein 72-81 C-C motif chemokine ligand 2 Homo sapiens 4-9 10720473-6 2000 N-Acetylcysteine, a potent antioxidant, also suppressed the GA-induced MCP-1 expression. Acetylcysteine 0-16 C-C motif chemokine ligand 2 Homo sapiens 71-76 10720473-6 2000 N-Acetylcysteine, a potent antioxidant, also suppressed the GA-induced MCP-1 expression. Gallium 60-62 C-C motif chemokine ligand 2 Homo sapiens 71-76 10720473-9 2000 GA-induced MCP-1 expression may be one of the mechanisms by which the diabetic patients suffer from accelerated atherosclerosis. Gallium 0-2 C-C motif chemokine ligand 2 Homo sapiens 11-16 10725264-13 2000 These findings suggest that 1,4-dihydropyridines such as nifedipine affect the expression of both potentially pro-arteriosclerotic (MCP-1) and anti-arteriosclerotic (iNOS) gene products in the vessel wall at the level of transcription, and that these effects are unrelated to their calcium channel-blocking properties. 1,4-dihydropyridine 28-48 C-C motif chemokine ligand 2 Homo sapiens 132-137 10725264-13 2000 These findings suggest that 1,4-dihydropyridines such as nifedipine affect the expression of both potentially pro-arteriosclerotic (MCP-1) and anti-arteriosclerotic (iNOS) gene products in the vessel wall at the level of transcription, and that these effects are unrelated to their calcium channel-blocking properties. Nifedipine 57-67 C-C motif chemokine ligand 2 Homo sapiens 132-137 10669634-5 2000 In this study, we show that TNF-alpha induces a parallel phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (p38MAPK) and increases MCP-1 mRNA expression in cultured VSMCs. vsmcs 226-231 C-C motif chemokine ligand 2 Homo sapiens 192-197 10669634-7 2000 Incubation of VSMCs with multiple antioxidants (diphenylene iodonium, liposomal superoxide dismutase, catalase, N-acetylcysteine, dimethylthiourea, and pyrrolidine dithiocarbamate) had no effect on TNF-alpha-mediated MCP-1 upregulation. vsmcs 14-19 C-C motif chemokine ligand 2 Homo sapiens 217-222 10669634-8 2000 However, simultaneous blockade of the ERK1/2 and ROS pathways by using PD098059 combined with diphenylene iodonium or N-acetylcysteine potently enhanced the ability of MAPK kinase inhibitors to abrogate MCP-1 mRNA expression (100+/-2% inhibition). 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one 71-79 C-C motif chemokine ligand 2 Homo sapiens 203-208 10669634-8 2000 However, simultaneous blockade of the ERK1/2 and ROS pathways by using PD098059 combined with diphenylene iodonium or N-acetylcysteine potently enhanced the ability of MAPK kinase inhibitors to abrogate MCP-1 mRNA expression (100+/-2% inhibition). diphenyleneiodonium 94-114 C-C motif chemokine ligand 2 Homo sapiens 203-208 10669634-8 2000 However, simultaneous blockade of the ERK1/2 and ROS pathways by using PD098059 combined with diphenylene iodonium or N-acetylcysteine potently enhanced the ability of MAPK kinase inhibitors to abrogate MCP-1 mRNA expression (100+/-2% inhibition). Acetylcysteine 118-134 C-C motif chemokine ligand 2 Homo sapiens 203-208 10669634-9 2000 Thus, parallel ROS-dependent and ERK1/2-dependent pathways converge to regulate TNF-alpha-induced MCP-1 gene expression in VSMCs. Reactive Oxygen Species 15-18 C-C motif chemokine ligand 2 Homo sapiens 98-103 10690939-0 2000 Inhibitory effect of troglitazone on tumor necrosis factor alpha-induced expression of monocyte chemoattractant protein-1 in human mesangial cells. Troglitazone 21-33 C-C motif chemokine ligand 2 Homo sapiens 87-121 10653823-6 2000 Preexposure of ECs for 18 hours with laminar shear stress (15 dyne/cm(2)) abrogated CS-induced IL-8 release to 106+/-10% (P<0.001) and reduced CS-induced MCP-1 expression (170+/-31%; P<0.05). Cesium 84-86 C-C motif chemokine ligand 2 Homo sapiens 157-162 10653823-9 2000 Specific inhibition of clusterin by transfection with antisense oligonucleotides reversed the protective effect of shear stress on CS-induced MCP-1 and IL-8 upregulation (P<0.05 versus sense-transfected cells). Oligonucleotides 64-80 C-C motif chemokine ligand 2 Homo sapiens 142-147 10653823-9 2000 Specific inhibition of clusterin by transfection with antisense oligonucleotides reversed the protective effect of shear stress on CS-induced MCP-1 and IL-8 upregulation (P<0.05 versus sense-transfected cells). Cesium 131-133 C-C motif chemokine ligand 2 Homo sapiens 142-147 10690908-4 2000 In the present study we report that estradiol (E2) enhances endometriotic cell responsiveness to the proinflammatory cytokine interleukin-1beta by up-regulating interleukin-1-induced monocyte chemotactic protein-1 (MCP-1) expression at the level of both protein secretion and messenger ribonucleic acid (mRNA) synthesis, whereas progesterone had no significant effects. Estradiol 36-45 C-C motif chemokine ligand 2 Homo sapiens 183-213 10690908-4 2000 In the present study we report that estradiol (E2) enhances endometriotic cell responsiveness to the proinflammatory cytokine interleukin-1beta by up-regulating interleukin-1-induced monocyte chemotactic protein-1 (MCP-1) expression at the level of both protein secretion and messenger ribonucleic acid (mRNA) synthesis, whereas progesterone had no significant effects. Estradiol 36-45 C-C motif chemokine ligand 2 Homo sapiens 215-220 10690908-4 2000 In the present study we report that estradiol (E2) enhances endometriotic cell responsiveness to the proinflammatory cytokine interleukin-1beta by up-regulating interleukin-1-induced monocyte chemotactic protein-1 (MCP-1) expression at the level of both protein secretion and messenger ribonucleic acid (mRNA) synthesis, whereas progesterone had no significant effects. Progesterone 329-341 C-C motif chemokine ligand 2 Homo sapiens 183-213 10690939-8 2000 We found that TNF-alpha increased the secretion of MCP-1 by 55-fold versus the control and troglitazone significantly inhibited this TNF-alpha-induced increase in MCP-1 secretion (49.3%). Troglitazone 91-103 C-C motif chemokine ligand 2 Homo sapiens 51-56 10690939-9 2000 Moreover, Northern blot analysis showed that troglitazone decreased the MCP-1 mRNA level in HMCs. Troglitazone 45-57 C-C motif chemokine ligand 2 Homo sapiens 72-77 10690939-10 2000 We demonstrated that alpha-tocopherol also inhibited TNF-alpha-induced MCP-1 production in HMCs, although its effects were not as strong as troglitazone. alpha-Tocopherol 21-37 C-C motif chemokine ligand 2 Homo sapiens 71-76 11866893-3 2000 The expression of MCP-1 mRNA in HUVECs was examined by dot blot analysis using a probe of gamma-(32)P-end-labelled 35 mer oligonucleotide. gamma-(32)p 90-101 C-C motif chemokine ligand 2 Homo sapiens 18-23 11866893-3 2000 The expression of MCP-1 mRNA in HUVECs was examined by dot blot analysis using a probe of gamma-(32)P-end-labelled 35 mer oligonucleotide. Oligonucleotides 122-137 C-C motif chemokine ligand 2 Homo sapiens 18-23 11866893-4 2000 Meanwhile, MCP-1 protein in the cytoplasm was detected by SABC immunostaining. sabc 58-62 C-C motif chemokine ligand 2 Homo sapiens 11-16 10547158-5 1999 Multivariate regression analysis revealed that significant predictors of MCP-1 value for males were age (p = 0.033) and serum triglyceride (p = 0.039). Triglycerides 126-138 C-C motif chemokine ligand 2 Homo sapiens 73-78 10607682-3 2000 In this study we show that activation of Vdelta2(+) cells with the nonpeptidic antigen isopentenyl pyrophosphate (IPP) rapidly induces (within 4-12 hours) the C-C chemokines MIP-1alpha, MIP-1beta, and lymphotactin but not MCP-1. isopentenyl pyrophosphate 87-112 C-C motif chemokine ligand 2 Homo sapiens 222-227 11240649-0 2000 Cytokines IL-1beta, IL-2, IL-6, IL-8, MCP-1, GM-CSF and TNFalpha in patients with epithelial ovarian cancer and their relationship to treatment with paclitaxel. Paclitaxel 149-159 C-C motif chemokine ligand 2 Homo sapiens 38-43 11240649-7 2000 In serum, IL-6, IL-8 and MCP-1 decreased with the administration of steroids prior to paclitaxel, and increased in the 24 h after paclitaxel. Steroids 68-76 C-C motif chemokine ligand 2 Homo sapiens 25-30 11240649-7 2000 In serum, IL-6, IL-8 and MCP-1 decreased with the administration of steroids prior to paclitaxel, and increased in the 24 h after paclitaxel. Paclitaxel 86-96 C-C motif chemokine ligand 2 Homo sapiens 25-30 11240649-7 2000 In serum, IL-6, IL-8 and MCP-1 decreased with the administration of steroids prior to paclitaxel, and increased in the 24 h after paclitaxel. Paclitaxel 130-140 C-C motif chemokine ligand 2 Homo sapiens 25-30 11240649-10 2000 Treatment with paclitaxel is associated with an increase in expression of a limited number of cytokines in patients with ovarian cancer, notably IL-6, IL-8 and MCP-1. Paclitaxel 15-25 C-C motif chemokine ligand 2 Homo sapiens 160-165 10683319-3 2000 Tetradecanoyl phorbol acetate (TPA) strongly increased the IL-8 and MCP-1 amounts in the culture supernatants of all five cell lines. Tetradecanoylphorbol Acetate 0-29 C-C motif chemokine ligand 2 Homo sapiens 68-73 10683319-3 2000 Tetradecanoyl phorbol acetate (TPA) strongly increased the IL-8 and MCP-1 amounts in the culture supernatants of all five cell lines. Tetradecanoylphorbol Acetate 31-34 C-C motif chemokine ligand 2 Homo sapiens 68-73 10911637-7 2000 HG-induced activation of diacylglycerol PKC (DAG-PKC) plays a major role in up-regulation of MCP-1, TGF beta 1, and fibronectin synthesis by HPMC cultured under HG. Diglycerides 25-39 C-C motif chemokine ligand 2 Homo sapiens 93-98 10911637-7 2000 HG-induced activation of diacylglycerol PKC (DAG-PKC) plays a major role in up-regulation of MCP-1, TGF beta 1, and fibronectin synthesis by HPMC cultured under HG. dag 45-48 C-C motif chemokine ligand 2 Homo sapiens 93-98 10589939-5 1999 METHODS: In vitro MCP-1 production by macrophages after stimulation with human neutrophil elastase (HNE) or oxygen radicals generated by hypoxanthine and xanthine oxidase was examined. Reactive Oxygen Species 108-123 C-C motif chemokine ligand 2 Homo sapiens 18-23 10589939-10 1999 RESULTS: Human neutrophil elastase or oxygen radicals significantly enhanced in vitro MCP-1 production by macrophage. Reactive Oxygen Species 38-53 C-C motif chemokine ligand 2 Homo sapiens 86-91 10589757-0 1999 Discovery of differentially expressed genes associated with paclitaxel resistance using cDNA array technology: analysis of interleukin (IL) 6, IL-8, and monocyte chemotactic protein 1 in the paclitaxel-resistant phenotype. Paclitaxel 191-201 C-C motif chemokine ligand 2 Homo sapiens 153-183 10547276-8 1999 The mean MCP-1 level for LPS-treated monocytes was 4903+/-1540 pg/ml 20 h for normal subjects and was significantly elevated in AH patients to 11589+/-3266 pg/ml/20 h. AH patient monocyte MCP-1 production was decreased in vitro when monocytes were treated with N-acetylcysteine (5 mM) and also decreased over the 6-month study as the patients improved clinically. Acetylcysteine 261-277 C-C motif chemokine ligand 2 Homo sapiens 9-14 10527705-6 1999 Infusion of NAc twice daily for 4 days following transplantation further altered chemokine mRNA expression (increased MCP-1 and RANTES; decreased CINC); led to more enhanced type 2 cytokine production relative to control animals; and further increased xenograft survival. Acetylcysteine 12-15 C-C motif chemokine ligand 2 Homo sapiens 118-123 10529171-2 1999 To identify the regions of MCP-1 that contact its receptor, CCR2, we substituted all surface-exposed residues with alanine. Alanine 115-122 C-C motif chemokine ligand 2 Homo sapiens 27-32 10529171-10 1999 Additional constraints at the ends of the peptide, corresponding to the disulfide between the first and third cysteines in MCP-1, yielded further improvements in affinity. Disulfides 72-81 C-C motif chemokine ligand 2 Homo sapiens 123-128 10529171-10 1999 Additional constraints at the ends of the peptide, corresponding to the disulfide between the first and third cysteines in MCP-1, yielded further improvements in affinity. Cysteine 110-119 C-C motif chemokine ligand 2 Homo sapiens 123-128 10520779-1 1999 OBJECTIVES: We investigated the effects of enalapril therapy on plasma tissue factor (TF), tissue factor pathway inhibitor (TFPI) and monocyte chemoattractant protein-1 (MCP-1) levels in patients with acute myocardial infarction. Enalapril 43-52 C-C motif chemokine ligand 2 Homo sapiens 134-168 11450070-4 2000 The ischemia-induced expression of ICAM-1 in HCEC, and the expression/release of IL-8 and MCP-1 in HCEC were abolished by the non-steroid anti-inflammatory drug, indomethacin (100-300 microM). Indomethacin 162-174 C-C motif chemokine ligand 2 Homo sapiens 90-95 11450070-5 2000 The immunosuppressant cyclosporin A (50 microM) partially reduced the ischemia-stimulated IL-8 and MCP-1 secretion by HCEC. Cyclosporine 22-35 C-C motif chemokine ligand 2 Homo sapiens 99-104 10614622-7 2000 XEs, bisphenol A, and NP also inhibited MCP-1 production, although the potency was 3-4 orders of magnitude lower than that of E2. {(1R,2R)-2-[4-(1H-tetrazol-5-yl)benzene-1-carbonyl]cyclopentyl}propanedioic acid 0-3 C-C motif chemokine ligand 2 Homo sapiens 40-45 10614622-7 2000 XEs, bisphenol A, and NP also inhibited MCP-1 production, although the potency was 3-4 orders of magnitude lower than that of E2. bisphenol A 5-16 C-C motif chemokine ligand 2 Homo sapiens 40-45 10614622-7 2000 XEs, bisphenol A, and NP also inhibited MCP-1 production, although the potency was 3-4 orders of magnitude lower than that of E2. Neptunium 22-24 C-C motif chemokine ligand 2 Homo sapiens 40-45 10614622-8 2000 E2, bisphenol A, and NP inhibited MCP-1 messenger RNA expression in MCF-7 cells. bisphenol A 4-15 C-C motif chemokine ligand 2 Homo sapiens 34-39 10614622-8 2000 E2, bisphenol A, and NP inhibited MCP-1 messenger RNA expression in MCF-7 cells. Neptunium 21-23 C-C motif chemokine ligand 2 Homo sapiens 34-39 10776798-0 2000 Delayed clearance of zymosan-induced granuloma and depressed phagocytosis of macrophages with concomitant up-regulated kinase activities of Src-family in a human monocyte chemoattractant protein-1 transgenic mouse. Zymosan 21-28 C-C motif chemokine ligand 2 Homo sapiens 162-196 10587439-2 1999 To identify which residues of MCP-1 contribute to signaling though CCR2, we mutated all the surface-exposed residues to alanine and other amino acids and made some selective large changes at the amino terminus. Alanine 120-127 C-C motif chemokine ligand 2 Homo sapiens 30-35 10559511-8 1999 Ang II and TNF-alpha induced the expression of IP-10 (1.5 and 3.4-fold) and MCP-1 (2.4 and 4-fold) in VSMC. vsmc 102-106 C-C motif chemokine ligand 2 Homo sapiens 76-81 10559511-9 1999 Atv reduced this overexpression around 38 and 35% (IP-10), and 54 and 39% (MCP-1), respectively. Atorvastatin 0-3 C-C motif chemokine ligand 2 Homo sapiens 75-80 10559516-6 1999 However, IL-1beta-induced productions of both MCP-1 and IL-8 were dose-dependently suppressed by enrichment of cells with vitamin E. Vitamin E 122-131 C-C motif chemokine ligand 2 Homo sapiens 46-51 10502563-8 1999 Dexamethasone (DEX) significantly inhibited cytokine-induced accumulation of MCP and RANTES mRNA, in contrast to IL-4, IL-10, and IL-13, which had no inhibitory effect on cytokine-induced chemokine expression. Dexamethasone 0-13 C-C motif chemokine ligand 2 Homo sapiens 77-80 10502563-8 1999 Dexamethasone (DEX) significantly inhibited cytokine-induced accumulation of MCP and RANTES mRNA, in contrast to IL-4, IL-10, and IL-13, which had no inhibitory effect on cytokine-induced chemokine expression. Dexamethasone 15-18 C-C motif chemokine ligand 2 Homo sapiens 77-80 10502563-9 1999 The cytokine-induced MCP mRNA expression in HASMC was associated with MCP release, which was inhibited by DEX and post-translationally by IL-4. Dexamethasone 106-109 C-C motif chemokine ligand 2 Homo sapiens 21-24 10502563-9 1999 The cytokine-induced MCP mRNA expression in HASMC was associated with MCP release, which was inhibited by DEX and post-translationally by IL-4. Dexamethasone 106-109 C-C motif chemokine ligand 2 Homo sapiens 70-73 10484461-0 1999 Effects of reactive oxygen and nitrogen metabolites on MCP-1-induced monocyte chemotactic activity in vitro. Oxygen 20-26 C-C motif chemokine ligand 2 Homo sapiens 55-60 10572396-4 1999 Urinary levels of MCAF/MCP-1 were significantly higher in patients with RPGN as compared with those of other renal diseases and healthy volunteers(21.8 +/- 4.5 vs. 11.6 +/- 3.5, 1.0 +/- 0.1 pg/ml creatinine, respectively, p < 0.01, mean +/- SEM). Creatinine 196-206 C-C motif chemokine ligand 2 Homo sapiens 18-22 10572396-4 1999 Urinary levels of MCAF/MCP-1 were significantly higher in patients with RPGN as compared with those of other renal diseases and healthy volunteers(21.8 +/- 4.5 vs. 11.6 +/- 3.5, 1.0 +/- 0.1 pg/ml creatinine, respectively, p < 0.01, mean +/- SEM). Creatinine 196-206 C-C motif chemokine ligand 2 Homo sapiens 23-28 10572396-9 1999 Moreover, elevated urinary MCAF/MCP-1 levels in patients with RPGN, regardless of subgroups, were dramatically decreased during methylprednisolone pulse therapy induced convalescence. Methylprednisolone 128-146 C-C motif chemokine ligand 2 Homo sapiens 27-31 10572396-9 1999 Moreover, elevated urinary MCAF/MCP-1 levels in patients with RPGN, regardless of subgroups, were dramatically decreased during methylprednisolone pulse therapy induced convalescence. Methylprednisolone 128-146 C-C motif chemokine ligand 2 Homo sapiens 32-37 10504268-3 1999 Chemokines bind to glycosaminoglycans on human umbilical vein endothelial cells (HUVECs) with affinities in the micromolar range: RANTES > MCP-1 > IL-8 > MIP-1alpha. Glycosaminoglycans 19-37 C-C motif chemokine ligand 2 Homo sapiens 142-147 10490587-5 1999 Dex had maximal effect at concentrations above 0.01 microM and was effective on both rat and human MCP-1 transcripts. Dexamethasone 0-3 C-C motif chemokine ligand 2 Homo sapiens 99-104 10477627-3 1999 Dexamethasone (Dex) up-regulated mRNA expression of the monocyte chemotactic protein (MCP-1, CCL2) chemokine receptor CCR2. Dexamethasone 0-13 C-C motif chemokine ligand 2 Homo sapiens 86-91 10477627-3 1999 Dexamethasone (Dex) up-regulated mRNA expression of the monocyte chemotactic protein (MCP-1, CCL2) chemokine receptor CCR2. Dexamethasone 0-13 C-C motif chemokine ligand 2 Homo sapiens 93-97 10477627-3 1999 Dexamethasone (Dex) up-regulated mRNA expression of the monocyte chemotactic protein (MCP-1, CCL2) chemokine receptor CCR2. Dexamethasone 0-3 C-C motif chemokine ligand 2 Homo sapiens 86-91 10477627-3 1999 Dexamethasone (Dex) up-regulated mRNA expression of the monocyte chemotactic protein (MCP-1, CCL2) chemokine receptor CCR2. Dexamethasone 0-3 C-C motif chemokine ligand 2 Homo sapiens 93-97 10484461-0 1999 Effects of reactive oxygen and nitrogen metabolites on MCP-1-induced monocyte chemotactic activity in vitro. Nitrogen 31-39 C-C motif chemokine ligand 2 Homo sapiens 55-60 10484461-2 1999 Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that attracts monocytes and has a tyrosine residue critical for function. Tyrosine 92-100 C-C motif chemokine ligand 2 Homo sapiens 0-34 10484461-2 1999 Monocyte chemoattractant protein-1 (MCP-1) is a chemokine that attracts monocytes and has a tyrosine residue critical for function. Tyrosine 92-100 C-C motif chemokine ligand 2 Homo sapiens 36-41 10484461-3 1999 We hypothesized that peroxynitrite would alter MCP-1 activity. Peroxynitrous Acid 21-34 C-C motif chemokine ligand 2 Homo sapiens 47-52 10484461-4 1999 Peroxynitrite attenuated MCP-1-induced monocyte chemotactic activity (MCA) in a dose-dependent manner (P < 0.05) but did not attenuate leukotriene B4 or complement-activated serum MCA. Peroxynitrous Acid 0-13 C-C motif chemokine ligand 2 Homo sapiens 25-30 10484461-7 1999 The peroxynitrite generator 3-morpholinosydnonimine caused a concentration-dependent inhibition of MCA by MCP-1. Peroxynitrous Acid 4-17 C-C motif chemokine ligand 2 Homo sapiens 106-111 10484461-7 1999 The peroxynitrite generator 3-morpholinosydnonimine caused a concentration-dependent inhibition of MCA by MCP-1. linsidomine 28-51 C-C motif chemokine ligand 2 Homo sapiens 106-111 10484461-8 1999 Peroxynitrite reduced MCP-1 binding to monocytes and resulted in nitrotyrosine formation. Peroxynitrous Acid 0-13 C-C motif chemokine ligand 2 Homo sapiens 22-27 10484461-9 1999 These findings are consistent with nitration of tyrosine by peroxynitrite, with subsequent inhibition of MCP-1 binding to monocytes, and suggest that peroxynitrite may play a role in regulation of MCP-1-induced monocyte chemotaxis. Tyrosine 48-56 C-C motif chemokine ligand 2 Homo sapiens 197-202 10484461-9 1999 These findings are consistent with nitration of tyrosine by peroxynitrite, with subsequent inhibition of MCP-1 binding to monocytes, and suggest that peroxynitrite may play a role in regulation of MCP-1-induced monocyte chemotaxis. Peroxynitrous Acid 60-73 C-C motif chemokine ligand 2 Homo sapiens 197-202 10484461-9 1999 These findings are consistent with nitration of tyrosine by peroxynitrite, with subsequent inhibition of MCP-1 binding to monocytes, and suggest that peroxynitrite may play a role in regulation of MCP-1-induced monocyte chemotaxis. Peroxynitrous Acid 150-163 C-C motif chemokine ligand 2 Homo sapiens 105-110 10479651-0 1999 9-cis retinoic acid induces monocyte chemoattractant protein-1 secretion in human monocytic THP-1 cells. Alitretinoin 0-19 C-C motif chemokine ligand 2 Homo sapiens 28-62 10484461-9 1999 These findings are consistent with nitration of tyrosine by peroxynitrite, with subsequent inhibition of MCP-1 binding to monocytes, and suggest that peroxynitrite may play a role in regulation of MCP-1-induced monocyte chemotaxis. Peroxynitrous Acid 150-163 C-C motif chemokine ligand 2 Homo sapiens 197-202 10479651-11 1999 These studies identify RA as a nuclear signal for MCP-1 induction in undifferentiated human monocytic cells. Tretinoin 23-25 C-C motif chemokine ligand 2 Homo sapiens 50-55 10479651-3 1999 In the current study, we show 9-cis retinoic acid (RA), a ligand for the nuclear hormone receptor retinoid X receptor (RXR) and retinoic acid receptor (RAR), markedly induces the expression of MCP-1. Alitretinoin 30-49 C-C motif chemokine ligand 2 Homo sapiens 193-198 10513809-11 1999 SP inhibited cytokine-stimulated HMVEC expression of IL-8 and MCP-1 (P<0.05; [n = 4]). Sulfapyridine 0-2 C-C motif chemokine ligand 2 Homo sapiens 62-67 10479651-3 1999 In the current study, we show 9-cis retinoic acid (RA), a ligand for the nuclear hormone receptor retinoid X receptor (RXR) and retinoic acid receptor (RAR), markedly induces the expression of MCP-1. Tretinoin 51-53 C-C motif chemokine ligand 2 Homo sapiens 193-198 10479651-4 1999 In human THP-1 monocytic leukemia cells cultured with RA (0.05 to 500 nmol/L), MCP-1 expression was induced rapidly, significantly, and dose-dependently by as much as 165-fold. Tretinoin 54-56 C-C motif chemokine ligand 2 Homo sapiens 79-84 10513809-13 1999 CONCLUSION: These results demonstrate that SSZ and its metabolite SP may affect the pathogenesis of RA by inhibiting EC chemotaxis, proliferation, tube formation, and expression of sICAM-1, IL-8, and MCP-1. Sulfasalazine 43-46 C-C motif chemokine ligand 2 Homo sapiens 200-205 10513809-13 1999 CONCLUSION: These results demonstrate that SSZ and its metabolite SP may affect the pathogenesis of RA by inhibiting EC chemotaxis, proliferation, tube formation, and expression of sICAM-1, IL-8, and MCP-1. Sulfapyridine 66-68 C-C motif chemokine ligand 2 Homo sapiens 200-205 10475624-4 1999 Stimulation of HL-60 and MONO-MAC-6 with lipopolysaccharide (LPS), and stimulation of ML-2 and MUTZ-3 with 12-tetradecanoyl phorbol 13-acetate (TPA) dramatically increased the MCP-1 level in the culture medium. Tetradecanoylphorbol Acetate 107-142 C-C motif chemokine ligand 2 Homo sapiens 176-181 10446112-8 1999 Serum MCP-1 concentrations correlated significantly with serum aspartate aminotransferase and creatinine. Creatinine 94-104 C-C motif chemokine ligand 2 Homo sapiens 6-11 10475624-5 1999 The highest amount of MCP-1 (> 80 ng/ml within 24 h) was achieved by TPA stimulation of MUTZ-3 cells. Tetradecanoylphorbol Acetate 72-75 C-C motif chemokine ligand 2 Homo sapiens 22-27 10475624-7 1999 While the antinflammatory cytokines IL-4, IL-10 and IL-13 failed to suppress MCP-1 secretion, the glucocorticoid dexamethasone strongly inhibited the MCP-1 production of unstimulated and stimulated MONO-MAC-6 cells. Dexamethasone 113-126 C-C motif chemokine ligand 2 Homo sapiens 150-155 10438958-9 1999 Paraformaldehyde-fixed CD40L-activated monocytes (to preserve membrane integrity but prevent secretory activity), cocultured with MC at various ratios, induced IL-6, MCP-1, and ICAM-1 synthesis by MC. paraform 0-16 C-C motif chemokine ligand 2 Homo sapiens 166-171 10551904-3 1999 We hypothesized that butyrate may alter IL-8 and MCP-1 expression by intestinal epithelial cells through histone acetylation. Butyrates 21-29 C-C motif chemokine ligand 2 Homo sapiens 49-54 10551904-8 1999 Butyrate reversibly decreased MCP-1 secretion. Butyrates 0-8 C-C motif chemokine ligand 2 Homo sapiens 30-35 11715462-0 1999 [The effects of L-arginine and nimodipine on the expression of monocyte chemoattractant protein-1 in endothelial cells induced by lipopolysaccharide]. Arginine 16-26 C-C motif chemokine ligand 2 Homo sapiens 63-97 11715462-0 1999 [The effects of L-arginine and nimodipine on the expression of monocyte chemoattractant protein-1 in endothelial cells induced by lipopolysaccharide]. Nimodipine 31-41 C-C motif chemokine ligand 2 Homo sapiens 63-97 11715462-1 1999 OBJECTIVE: To examine the effects of L-arginine and nimodipine on the expression of monocyte chemoattractant protein-1 (MCP-1) mRNA and protein induced by lipopolysaccharide (LPS) in endothelial cells (ECs). Arginine 37-47 C-C motif chemokine ligand 2 Homo sapiens 84-118 11715462-1 1999 OBJECTIVE: To examine the effects of L-arginine and nimodipine on the expression of monocyte chemoattractant protein-1 (MCP-1) mRNA and protein induced by lipopolysaccharide (LPS) in endothelial cells (ECs). Arginine 37-47 C-C motif chemokine ligand 2 Homo sapiens 120-125 11715462-1 1999 OBJECTIVE: To examine the effects of L-arginine and nimodipine on the expression of monocyte chemoattractant protein-1 (MCP-1) mRNA and protein induced by lipopolysaccharide (LPS) in endothelial cells (ECs). Nimodipine 52-62 C-C motif chemokine ligand 2 Homo sapiens 84-118 11715462-1 1999 OBJECTIVE: To examine the effects of L-arginine and nimodipine on the expression of monocyte chemoattractant protein-1 (MCP-1) mRNA and protein induced by lipopolysaccharide (LPS) in endothelial cells (ECs). Nimodipine 52-62 C-C motif chemokine ligand 2 Homo sapiens 120-125 11715462-3 1999 The MCP-1 mRNA expression in ECs was examined by Dot blot analysis using a gamma-32P-end-labeled 35 mer oligonucleotide probe of MCP-1. gamma-32p 75-84 C-C motif chemokine ligand 2 Homo sapiens 4-9 11715462-3 1999 The MCP-1 mRNA expression in ECs was examined by Dot blot analysis using a gamma-32P-end-labeled 35 mer oligonucleotide probe of MCP-1. Oligonucleotides 104-119 C-C motif chemokine ligand 2 Homo sapiens 4-9 11715462-9 1999 The MCP-1 protein content in the EC-CM of the LPS + L-arginine group and the LPS + nimodipine group was significantly lower than that of the LPS group (P < 0.01). Arginine 52-62 C-C motif chemokine ligand 2 Homo sapiens 4-9 11715462-11 1999 CONCLUSION: L-arginine and nimodipine can markedly inhibit the expression of MCP-1 in ECs induced by LPS. Arginine 12-22 C-C motif chemokine ligand 2 Homo sapiens 77-82 11715462-11 1999 CONCLUSION: L-arginine and nimodipine can markedly inhibit the expression of MCP-1 in ECs induced by LPS. Nimodipine 27-37 C-C motif chemokine ligand 2 Homo sapiens 77-82 10411539-6 1999 Adherence of ESC to various ECM substrates, except for poly-L-lysine, a non-integrin-dependent adhesion matrix, induced the expression of MCP-1 at both mRNA and protein levels. Lysine 55-68 C-C motif chemokine ligand 2 Homo sapiens 138-143 10419877-5 1999 Furthermore, the biologic response to MCP-1, as measured by intracellular calcium ions increase and chemotactic response, was lost in 7-day-cultured macrophages. Calcium 74-81 C-C motif chemokine ligand 2 Homo sapiens 38-43 10411539-8 1999 Disruption of the actin cytoskeleton by treating ESC with cytochalasin D completely blocked the increase of MCP-1 induced in response to integrin activation. Cytochalasin D 58-72 C-C motif chemokine ligand 2 Homo sapiens 108-113 10417209-3 1999 Lipoarabinomannan induced IL-8, MCP-1, and MIP-1beta in vitro, which was partly inhibited by anti-tumor necrosis factor antibody. lipoarabinomannan 0-17 C-C motif chemokine ligand 2 Homo sapiens 32-37 10444270-0 1999 Low-density lipoproteins enhance transforming growth factor-beta 1 (TGF-beta 1) and monocyte chemotactic protein-1 (MCP-1) expression induced by cyclosporin in human mesangial cells. Cyclosporine 145-156 C-C motif chemokine ligand 2 Homo sapiens 84-114 10444270-0 1999 Low-density lipoproteins enhance transforming growth factor-beta 1 (TGF-beta 1) and monocyte chemotactic protein-1 (MCP-1) expression induced by cyclosporin in human mesangial cells. Cyclosporine 145-156 C-C motif chemokine ligand 2 Homo sapiens 116-121 10444270-4 1999 Thus, the combined effect of CsA and low-density lipoprotein (LDL) on the gene and protein expression of MCP-1 and TGF-beta 1 in cultured human mesangial cells (HMC) was explored. Cyclosporine 29-32 C-C motif chemokine ligand 2 Homo sapiens 105-110 10444270-6 1999 The simultaneous addition of CsA and LDL did not display any additive effect on target gene expression, but it caused a synergistic effect on MCP-1 and TGF-beta 1 protein secretion into culture medium. Cyclosporine 29-32 C-C motif chemokine ligand 2 Homo sapiens 142-147 10383577-7 1999 At the highest concentration of tetracycline (100 microg/ml) median MMP-9 secretion was reduced from 27 to 5 ng/ml (P = 0.007) and median MCP-1 secretion was reduced from 50 to 10 ng/ml (P = 0.008). Tetracycline 32-44 C-C motif chemokine ligand 2 Homo sapiens 138-143 10449434-6 1999 Support for this hypothesis came from experiments showing that FN120 treatment significantly reduced both spontaneous and MCP-1-induced monocyte migration on an FN-impregnated collagen matrix. fn120 63-68 C-C motif chemokine ligand 2 Homo sapiens 122-127 10464551-10 1999 MTX treatment significantly lowered the serum levels of RANTES, GRO-alpha and MCP-1. Methotrexate 0-3 C-C motif chemokine ligand 2 Homo sapiens 78-83 10383577-6 1999 Tetracycline inhibited, in a concentration-dependent manner, both MMP-9 and MCP-1 secretion (P = 0.022 and P = 0.018 respectively), but did not alter hydroxyproline or IL-6 secretion. Tetracycline 0-12 C-C motif chemokine ligand 2 Homo sapiens 76-81 10395294-3 1999 The growth of the HC11 cells was drastically inhibited by Mg2+ depletion whereas the MCF-7 cells were only slightly inhibited (about 50% and 15%, respectively, after incubation in 0.05 mM Mg for 48 h). magnesium ion 58-62 C-C motif chemokine ligand 2 Homo sapiens 18-22 10395294-6 1999 Extracellular magnesium depletion was associated with increased expression of the cyclin-dependent kinase inhibitor p27Kip1 and decreased expression of cyclin D1 in the HC11 but not in the MCF-7 cells. Magnesium 14-23 C-C motif chemokine ligand 2 Homo sapiens 169-173 10395294-7 1999 We also demonstrated that Mg2+ depletion does not inhibit kinase activities in the normal HC11 cells and that Mg2+-restricted HC11 cells are still responsive to the epidermal growth factor (EGF)- and insulin-mediated stimulation of cell growth. magnesium ion 110-114 C-C motif chemokine ligand 2 Homo sapiens 126-130 10413089-0 1999 Thiazolidinedione inhibits the production of monocyte chemoattractant protein-1 in cytokine-treated human vascular endothelial cells. 2,4-thiazolidinedione 0-17 C-C motif chemokine ligand 2 Homo sapiens 45-79 10413089-3 1999 In this study, we examined the effects of a thiazolidinedione on monocyte chemoattractant protein-1 expression in human vascular endothelial cells. 2,4-thiazolidinedione 44-61 C-C motif chemokine ligand 2 Homo sapiens 65-99 10413089-6 1999 In summary, our results indicated that the suppression of the expression of monocyte chemoattractant protein-1 can be accomplished by thiazolidinedione treatment, raising the possibility that thiazolidinedione may be of therapeutic value in the treatment of diseases such as atherosclerosis. 2,4-thiazolidinedione 134-151 C-C motif chemokine ligand 2 Homo sapiens 76-110 10413089-6 1999 In summary, our results indicated that the suppression of the expression of monocyte chemoattractant protein-1 can be accomplished by thiazolidinedione treatment, raising the possibility that thiazolidinedione may be of therapeutic value in the treatment of diseases such as atherosclerosis. 2,4-thiazolidinedione 192-209 C-C motif chemokine ligand 2 Homo sapiens 76-110 10377035-0 1999 Regulation of monocyte chemotactic protein-1 expression in human endometrial stromal cells by estrogen and progesterone. Progesterone 107-119 C-C motif chemokine ligand 2 Homo sapiens 14-44 10377035-4 1999 We hypothesized that sex steroids may be involved in the regulation of macrophage migration by regulating MCP-1 expression. Steroids 25-33 C-C motif chemokine ligand 2 Homo sapiens 106-111 10377035-5 1999 We investigated the regulation of MCP-1 expression in human endometrial stromal cells by estradiol 17beta (E2) and progestins. Estradiol 89-98 C-C motif chemokine ligand 2 Homo sapiens 34-39 10229865-13 1999 The concentrations of IL-8, G-CSF, monocyte chemoattractant protein-1, GM-CSF, and TGF-beta in the supernatant fluids significantly increased in response to bleomycin. Bleomycin 157-166 C-C motif chemokine ligand 2 Homo sapiens 35-69 10330162-1 1999 We have demonstrated previously that the seven-nucleotide (nt) motif TTTTGTA (the heptamer) that is present within the proximal 3" untranslated sequences of numerous immediate-early genes is essential for platelet-derived growth factor (PDGF)-stimulated induction of the MCP-1 immediate-early gene. seven-nucleotide 41-57 C-C motif chemokine ligand 2 Homo sapiens 271-276 10330162-5 1999 One inhibitory element is contained within a 59-nt portion of MCP-1 5" flanking sequences and functions in an orientation-independent and heptamer-regulated manner. 59-nt 45-50 C-C motif chemokine ligand 2 Homo sapiens 62-67 10361347-7 1999 CONCLUSION: TC rapidly penetrates AAA wall in vivo and inhibits MMP-9 and MCP-1 release by AAA explants. Tetracycline 13-15 C-C motif chemokine ligand 2 Homo sapiens 75-80 10408835-6 1999 Further support for mismatch repair being involved in sensitivity of the minor groove alkylators is that two cisplatin-resistant sublines of the human ovarian adenocarcinoma cell line A2780 (A2780/CP70 and A2780/MCP-1) are defective in hMLH1 expression and are more resistant to these agents than the parental mismatch repair proficient cells. Cisplatin 109-118 C-C motif chemokine ligand 2 Homo sapiens 206-217 10331497-2 1999 MCP-1 mRNA was first detected by Northern analysis at 8 h, and the peak level was detected at 16 h and sustained until 72 h. Cycloheximide and genistein, but not pertussis toxin, inhibited the expression of MCP-1 mRNA. Genistein 143-152 C-C motif chemokine ligand 2 Homo sapiens 0-5 10422564-6 1999 Anti-hMCP-1 antibody significantly inhibited the DNFB-included CHR in Tgm. Dinitrofluorobenzene 49-53 C-C motif chemokine ligand 2 Homo sapiens 5-11 10422564-11 1999 Moreover, administration of recombinant hMCP-1 to BALB/c mice led to an increase of FITC+NLDC-145+ cells in the DLN. Fluorescein-5-isothiocyanate 84-88 C-C motif chemokine ligand 2 Homo sapiens 40-54 10331497-2 1999 MCP-1 mRNA was first detected by Northern analysis at 8 h, and the peak level was detected at 16 h and sustained until 72 h. Cycloheximide and genistein, but not pertussis toxin, inhibited the expression of MCP-1 mRNA. Genistein 143-152 C-C motif chemokine ligand 2 Homo sapiens 207-212 10331497-2 1999 MCP-1 mRNA was first detected by Northern analysis at 8 h, and the peak level was detected at 16 h and sustained until 72 h. Cycloheximide and genistein, but not pertussis toxin, inhibited the expression of MCP-1 mRNA. Cycloheximide 125-138 C-C motif chemokine ligand 2 Homo sapiens 0-5 10329481-7 1999 FK506 further showed a suppressive effect on eotaxin and MCP-1 release from eosinophils. Tacrolimus 0-5 C-C motif chemokine ligand 2 Homo sapiens 57-62 10331497-2 1999 MCP-1 mRNA was first detected by Northern analysis at 8 h, and the peak level was detected at 16 h and sustained until 72 h. Cycloheximide and genistein, but not pertussis toxin, inhibited the expression of MCP-1 mRNA. Cycloheximide 125-138 C-C motif chemokine ligand 2 Homo sapiens 207-212 10209033-5 1999 Binding of labeled MCP-1 and MIP-1alpha could be inhibited by unlabeled homologous but not heterologous chemokine, and was independent of the presence of heparan sulfate, laminin, or collagen in the subendothelial matrix. Heparitin Sulfate 154-169 C-C motif chemokine ligand 2 Homo sapiens 19-24 10195928-7 1999 NO synthase inhibitor NG-amino-L-arginine (L-NAA) was found to markedly enhance MCP-1 and PDGF-A expression induced by step flow, but decrease their expression induced by impulse flow, in a dose-dependent manner. N(G)-aminoarginine 22-41 C-C motif chemokine ligand 2 Homo sapiens 80-85 10195928-7 1999 NO synthase inhibitor NG-amino-L-arginine (L-NAA) was found to markedly enhance MCP-1 and PDGF-A expression induced by step flow, but decrease their expression induced by impulse flow, in a dose-dependent manner. NG-amino-L-Arginine (hydrochloride) 43-48 C-C motif chemokine ligand 2 Homo sapiens 80-85 10195928-8 1999 NO donor spermine-NONOate (SPR/NO) dose-dependently reduced the MCP-1 and PDGF-A expression induced by impulse flow. spermine nitric oxide complex 9-25 C-C motif chemokine ligand 2 Homo sapiens 64-69 10080106-0 1999 Acute alcohol consumption attenuates interleukin-8 (IL-8) and monocyte chemoattractant peptide-1 (MCP-1) induction in response to ex vivo stimulation. Alcohols 6-13 C-C motif chemokine ligand 2 Homo sapiens 62-96 10097088-4 1999 Monocyte chemoattractant protein (MCP)-1-triggered receptor dimerization was studied in human embryonic kidney (HEK)-293 cells cotransfected with genes coding for the CCR2b receptor tagged with YSK or Myc sequences. tyrosylseryllysine 194-197 C-C motif chemokine ligand 2 Homo sapiens 0-40 9987092-11 1999 Intense staining for endothelin-1, RANTES, and monocyte chemoattractant protein-1 mRNAs selectively localized at tubular epithelial cells was found in biopsies taken from patients with CsA nephrotoxicity, but not in the chronic graft rejection group, whose tubuli had only minimal staining for RANTES mRNA on a few occasions. Cyclosporine 185-188 C-C motif chemokine ligand 2 Homo sapiens 47-81 10092776-2 1999 Pretreatment of NK cells with wortmannin inhibits the in vitro chemotaxis of NK cells induced by lymphotactin, monocyte-chemoattractant protein-1, RANTES, IFN-inducible protein-10, or stromal-derived factor-1 alpha. Wortmannin 30-40 C-C motif chemokine ligand 2 Homo sapiens 111-145 9888867-5 1999 In unstimulated MNCs, mRNA steady-state levels of PDGF-A, PDGF-B, and MCP-1 were reduced by 25+/-10%, 31+/-13%, and 40+/-14%, respectively, after omega-3 fatty acid ingestion, as assessed by quantitative polymerase chain reaction (all P<0.05). Fatty Acids, Omega-3 146-164 C-C motif chemokine ligand 2 Homo sapiens 70-75 9888867-9 1999 We conclude that human gene expression for PDGF-A, PDGF-B, and MCP-1, factors thought relevant to atherosclerosis, is constitutive, is constant, and can be reduced only by dietary omega-3 fatty acids in unstimulated and adherence-activated monocytes. Fatty Acids, Omega-3 180-199 C-C motif chemokine ligand 2 Homo sapiens 63-68 9862860-13 1999 Exposure of HSC to MCP-1 was associated with an increase in cytosolic calcium concentration, PI 3-K activity, protein tyrosine phosphorylation. Calcium 70-77 C-C motif chemokine ligand 2 Homo sapiens 19-24 9862860-13 1999 Exposure of HSC to MCP-1 was associated with an increase in cytosolic calcium concentration, PI 3-K activity, protein tyrosine phosphorylation. Tyrosine 118-126 C-C motif chemokine ligand 2 Homo sapiens 19-24 9920091-1 1999 The role of progesterone (P4) in the regulation of inflammatory mediators interleukin-8 (IL-8), monocyte chemoattractant protein-1, and cyclooxygenase-2 (COX-2) and in the recruitment of leukocyte subpopulations in the endometrium has been examined, by employing a model of P4 withdrawal and maintenance in vivo. Progesterone 12-24 C-C motif chemokine ligand 2 Homo sapiens 96-130 10080106-0 1999 Acute alcohol consumption attenuates interleukin-8 (IL-8) and monocyte chemoattractant peptide-1 (MCP-1) induction in response to ex vivo stimulation. Alcohols 6-13 C-C motif chemokine ligand 2 Homo sapiens 98-103 9853284-6 1998 RESULTS: Apical stimulation of HPMC with IL-1 beta or TNF alpha resulted in a time and dose dependent up-regulation of IL-8, MCP-1 and RANTES mRNA expression and synthesis. hydroxypropylmethylcellulose-lactose matrix 31-35 C-C motif chemokine ligand 2 Homo sapiens 125-130 10051376-5 1999 Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 55-60 10051376-5 1999 Curcumin inhibited the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages in a concentration- and a time-dependent manner. Tetradecanoylphorbol Acetate 89-92 C-C motif chemokine ligand 2 Homo sapiens 55-60 10051376-6 1999 These results show that curcumin exhibits an inhibitory effect on the production of IL-8, MIP-1alpha, MCP-1, IL-1beta, and TNF-alpha by PMA- or LPS-stimulated monocytes and alveolar macrophages. Curcumin 24-32 C-C motif chemokine ligand 2 Homo sapiens 102-107 9886550-9 1998 PGE2 stimulated release of MCP-1, IL-8 and IL-10 into the maternal and of MCP-1 and IL-8 into the fetal circulation of the placenta but had no effect on RANTES release. Dinoprostone 0-4 C-C motif chemokine ligand 2 Homo sapiens 27-32 9886550-9 1998 PGE2 stimulated release of MCP-1, IL-8 and IL-10 into the maternal and of MCP-1 and IL-8 into the fetal circulation of the placenta but had no effect on RANTES release. Dinoprostone 0-4 C-C motif chemokine ligand 2 Homo sapiens 74-79 10065903-6 1998 Cocaine also augmented apoptosis of brain endothelial cells and monocytes, increased secretion of four chemokines (interleukin-8, interferon-inducible protein-10, macrophage inflammatory protein-1alpha, and monocyte chemoattractant protein-1) and the cytokine, TNF-alpha, by human monocytes. Cocaine 0-7 C-C motif chemokine ligand 2 Homo sapiens 207-241 10068024-6 1999 Ti-alloy and PMMA particles increased expression of MCP-1 and MIP-1alpha in macrophages in vitro in a dose- and time-dependent manner whereas RANTES was not detected. Titanium 0-8 C-C motif chemokine ligand 2 Homo sapiens 52-57 10068024-6 1999 Ti-alloy and PMMA particles increased expression of MCP-1 and MIP-1alpha in macrophages in vitro in a dose- and time-dependent manner whereas RANTES was not detected. Polymethyl Methacrylate 13-17 C-C motif chemokine ligand 2 Homo sapiens 52-57 9865755-11 1998 CONCLUSIONS: These results suggest that MCAF/MCP-1, which is produced constantly by monocytes and macrophages and is stored in human nasal mucosa, possibly participates in the protracted histamine release from basophils and in the pathogenesis of perennial allergic rhinitis. Histamine 187-196 C-C motif chemokine ligand 2 Homo sapiens 40-44 9865755-11 1998 CONCLUSIONS: These results suggest that MCAF/MCP-1, which is produced constantly by monocytes and macrophages and is stored in human nasal mucosa, possibly participates in the protracted histamine release from basophils and in the pathogenesis of perennial allergic rhinitis. Histamine 187-196 C-C motif chemokine ligand 2 Homo sapiens 45-50 10209485-3 1998 To investigate the molecular mechanism leading to the TAM-rich stroma, the expression of a monocyte-specific chemotactic and activating factor, monocyte chemoattractant protein-1 (MCP-1), was studied by reverse transcriptase-polymerase chain reaction (RT-PCR) and in situ hybridization (ISH), and the presence of TAMs was demonstrated by immunohistochemistry in nine LELCs. tam 54-57 C-C motif chemokine ligand 2 Homo sapiens 144-178 10209485-3 1998 To investigate the molecular mechanism leading to the TAM-rich stroma, the expression of a monocyte-specific chemotactic and activating factor, monocyte chemoattractant protein-1 (MCP-1), was studied by reverse transcriptase-polymerase chain reaction (RT-PCR) and in situ hybridization (ISH), and the presence of TAMs was demonstrated by immunohistochemistry in nine LELCs. tam 54-57 C-C motif chemokine ligand 2 Homo sapiens 180-185 10209485-3 1998 To investigate the molecular mechanism leading to the TAM-rich stroma, the expression of a monocyte-specific chemotactic and activating factor, monocyte chemoattractant protein-1 (MCP-1), was studied by reverse transcriptase-polymerase chain reaction (RT-PCR) and in situ hybridization (ISH), and the presence of TAMs was demonstrated by immunohistochemistry in nine LELCs. tams 313-317 C-C motif chemokine ligand 2 Homo sapiens 144-178 10209485-3 1998 To investigate the molecular mechanism leading to the TAM-rich stroma, the expression of a monocyte-specific chemotactic and activating factor, monocyte chemoattractant protein-1 (MCP-1), was studied by reverse transcriptase-polymerase chain reaction (RT-PCR) and in situ hybridization (ISH), and the presence of TAMs was demonstrated by immunohistochemistry in nine LELCs. tams 313-317 C-C motif chemokine ligand 2 Homo sapiens 180-185 9853284-11 1998 CONCLUSIONS: These data demonstrate that HPMC synthesize IL-8, MCP-1 and RANTES in response to inflammatory cytokines. hydroxypropylmethylcellulose-lactose matrix 41-45 C-C motif chemokine ligand 2 Homo sapiens 63-68 9792213-7 1998 In fact, treatments of animals with (1) histamine H1 or serotonin antagonists or with (2) the mast cell stabilizer cromolyn or with (3) prior depletion of intact mast cells are maneuvers that successfully reduce eosinophil, neutrophil and monocyte extravasation in response to eotaxin, interleukin-8 or monocyte chemoattractant protein-1, respectively. histamine h1 40-52 C-C motif chemokine ligand 2 Homo sapiens 303-337 9792674-0 1998 Lysine 58 and histidine 66 at the C-terminal alpha-helix of monocyte chemoattractant protein-1 are essential for glycosaminoglycan binding. Lysine 0-6 C-C motif chemokine ligand 2 Homo sapiens 60-94 9792674-0 1998 Lysine 58 and histidine 66 at the C-terminal alpha-helix of monocyte chemoattractant protein-1 are essential for glycosaminoglycan binding. Histidine 14-23 C-C motif chemokine ligand 2 Homo sapiens 60-94 9792674-3 1998 MCP-1 showed binding to [3H]heparin with a KD of 1.5 microM. Tritium 25-27 C-C motif chemokine ligand 2 Homo sapiens 0-5 9792674-3 1998 MCP-1 showed binding to [3H]heparin with a KD of 1.5 microM. Heparin 28-35 C-C motif chemokine ligand 2 Homo sapiens 0-5 9792674-4 1998 We substituted lysine or histidine residues at the C-terminal end of MCP-1 with alanine residues and tested these mutants for their ability to bind heparin, heparan sulfate, hyaluronic acid, and chondroitin sulfate-C. Lysine 15-21 C-C motif chemokine ligand 2 Homo sapiens 69-74 9792674-4 1998 We substituted lysine or histidine residues at the C-terminal end of MCP-1 with alanine residues and tested these mutants for their ability to bind heparin, heparan sulfate, hyaluronic acid, and chondroitin sulfate-C. Histidine 25-34 C-C motif chemokine ligand 2 Homo sapiens 69-74 9792674-4 1998 We substituted lysine or histidine residues at the C-terminal end of MCP-1 with alanine residues and tested these mutants for their ability to bind heparin, heparan sulfate, hyaluronic acid, and chondroitin sulfate-C. Heparin 148-155 C-C motif chemokine ligand 2 Homo sapiens 69-74 9792674-4 1998 We substituted lysine or histidine residues at the C-terminal end of MCP-1 with alanine residues and tested these mutants for their ability to bind heparin, heparan sulfate, hyaluronic acid, and chondroitin sulfate-C. Heparitin Sulfate 157-172 C-C motif chemokine ligand 2 Homo sapiens 69-74 9792674-4 1998 We substituted lysine or histidine residues at the C-terminal end of MCP-1 with alanine residues and tested these mutants for their ability to bind heparin, heparan sulfate, hyaluronic acid, and chondroitin sulfate-C. Hyaluronic Acid 174-189 C-C motif chemokine ligand 2 Homo sapiens 69-74 9792674-4 1998 We substituted lysine or histidine residues at the C-terminal end of MCP-1 with alanine residues and tested these mutants for their ability to bind heparin, heparan sulfate, hyaluronic acid, and chondroitin sulfate-C. Chondroitin Sulfates 195-214 C-C motif chemokine ligand 2 Homo sapiens 69-74 9792674-9 1998 Therefore, we conclude that the Lys-58 and His-66 residues in the C-terminal alpha-helix of MCP-1 are essential for glycosaminoglycan binding and probably for the binding to the endothelial surface proteoglycans. Lysine 32-35 C-C motif chemokine ligand 2 Homo sapiens 92-97 9792674-9 1998 Therefore, we conclude that the Lys-58 and His-66 residues in the C-terminal alpha-helix of MCP-1 are essential for glycosaminoglycan binding and probably for the binding to the endothelial surface proteoglycans. Histidine 43-46 C-C motif chemokine ligand 2 Homo sapiens 92-97 9792674-9 1998 Therefore, we conclude that the Lys-58 and His-66 residues in the C-terminal alpha-helix of MCP-1 are essential for glycosaminoglycan binding and probably for the binding to the endothelial surface proteoglycans. Glycosaminoglycans 116-133 C-C motif chemokine ligand 2 Homo sapiens 92-97 9748276-2 1998 We report here that MCP-1 stimulates the formation of the lipid products of phosphatidylinositol (PI) 3-kinase, namely phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (PI 3,4,5-P3) in THP-1 cells that can be inhibited by pertussis toxin but not wortmannin. Phosphatidylinositols 76-96 C-C motif chemokine ligand 2 Homo sapiens 20-25 9748276-2 1998 We report here that MCP-1 stimulates the formation of the lipid products of phosphatidylinositol (PI) 3-kinase, namely phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (PI 3,4,5-P3) in THP-1 cells that can be inhibited by pertussis toxin but not wortmannin. phosphatidylinositol 3,4-diphosphate 119-156 C-C motif chemokine ligand 2 Homo sapiens 20-25 9748276-2 1998 We report here that MCP-1 stimulates the formation of the lipid products of phosphatidylinositol (PI) 3-kinase, namely phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (PI 3,4,5-P3) in THP-1 cells that can be inhibited by pertussis toxin but not wortmannin. phosphatidylinositol 3,4,5-triphosphate 161-201 C-C motif chemokine ligand 2 Homo sapiens 20-25 9748276-2 1998 We report here that MCP-1 stimulates the formation of the lipid products of phosphatidylinositol (PI) 3-kinase, namely phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (PI 3,4,5-P3) in THP-1 cells that can be inhibited by pertussis toxin but not wortmannin. Wortmannin 280-290 C-C motif chemokine ligand 2 Homo sapiens 20-25 9748276-5 1998 MCP-1 also induced tyrosine phosphorylation of three proteins in these cells, and a fourth tyrosine-phosphorylated protein co-precipitates with the p85 subunit upon MCP-1 stimulation. Tyrosine 19-27 C-C motif chemokine ligand 2 Homo sapiens 0-5 9748276-5 1998 MCP-1 also induced tyrosine phosphorylation of three proteins in these cells, and a fourth tyrosine-phosphorylated protein co-precipitates with the p85 subunit upon MCP-1 stimulation. Tyrosine 91-99 C-C motif chemokine ligand 2 Homo sapiens 165-170 9748276-7 1998 Moreover, this MCP-1-induced increase in PI3K-C2alpha activity was insensitive to wortmannin but was inhibited by pertussis toxin pretreatment. Wortmannin 82-92 C-C motif chemokine ligand 2 Homo sapiens 15-20 9748276-8 1998 Since this mirrored the effects of these inhibitors on MCP-1-stimulated increases in D-3 phosphatidylinositol lipid accumulation in vivo, these results suggest that activation of PI3K-C2alpha rather than the p85/p110 heterodimer is responsible for mediating the in vivo formation of D-3 phosphatidylinositol lipids. d-3 phosphatidylinositol lipid 85-115 C-C motif chemokine ligand 2 Homo sapiens 55-60 9748276-8 1998 Since this mirrored the effects of these inhibitors on MCP-1-stimulated increases in D-3 phosphatidylinositol lipid accumulation in vivo, these results suggest that activation of PI3K-C2alpha rather than the p85/p110 heterodimer is responsible for mediating the in vivo formation of D-3 phosphatidylinositol lipids. d-3 phosphatidylinositol lipids 283-314 C-C motif chemokine ligand 2 Homo sapiens 55-60 9794205-12 1998 Dexamethasone reduced levels of MCP-1 and MIP-1alpha, but not MIP-2, consistent with the observed pattern of inflammatory cell changes. Dexamethasone 0-13 C-C motif chemokine ligand 2 Homo sapiens 32-37 9792213-7 1998 In fact, treatments of animals with (1) histamine H1 or serotonin antagonists or with (2) the mast cell stabilizer cromolyn or with (3) prior depletion of intact mast cells are maneuvers that successfully reduce eosinophil, neutrophil and monocyte extravasation in response to eotaxin, interleukin-8 or monocyte chemoattractant protein-1, respectively. Cromolyn Sodium 115-123 C-C motif chemokine ligand 2 Homo sapiens 303-337 9710230-4 1998 TIL matrix invasion elicited by TC is inhibited by the addition of neutralizing antisera specific for IL-8 and MCP-1, demonstrating the direct relationship between chemokine release by TC and TIL invasion. Technetium 32-34 C-C motif chemokine ligand 2 Homo sapiens 111-116 9743506-7 1998 Liposomal transfection of a double-stranded kappaB phosphorothioate oligonucleotide, but not of the mutated form, inhibited MCP-1 secretion and surface expression of ICAM-1 on activated endothelium (P<0.05). Parathion 51-67 C-C motif chemokine ligand 2 Homo sapiens 124-129 9743506-7 1998 Liposomal transfection of a double-stranded kappaB phosphorothioate oligonucleotide, but not of the mutated form, inhibited MCP-1 secretion and surface expression of ICAM-1 on activated endothelium (P<0.05). Oligonucleotides 68-83 C-C motif chemokine ligand 2 Homo sapiens 124-129 9696841-8 1998 The MCP-1-induced calcium mobilization mediated by CCR2b signaling was unaffected by the polymorphism, but MCP-1 signaling mediated by either CCR2b- or CCR2-V64I-encoded receptors resulted in heterologous desensitization (i.e., limiting the signal response of other receptors) of both CCR5 and CXCR4. Calcium 18-25 C-C motif chemokine ligand 2 Homo sapiens 4-9 9849654-1 1998 This study was undertaken to assess whether gamma-linolenic acid (GLA) in the form of evening primrose oil (EPO) could affect rat serum cytokines, interferon-gamma (IFN-gamma), monocyte chemotactic protein-1 (MCP-1) and tumour necrosis factor-alpha (TNF-alpha). gamma-Linolenic Acid 44-64 C-C motif chemokine ligand 2 Homo sapiens 177-207 9849654-1 1998 This study was undertaken to assess whether gamma-linolenic acid (GLA) in the form of evening primrose oil (EPO) could affect rat serum cytokines, interferon-gamma (IFN-gamma), monocyte chemotactic protein-1 (MCP-1) and tumour necrosis factor-alpha (TNF-alpha). gamma-Linolenic Acid 66-69 C-C motif chemokine ligand 2 Homo sapiens 177-207 9849654-1 1998 This study was undertaken to assess whether gamma-linolenic acid (GLA) in the form of evening primrose oil (EPO) could affect rat serum cytokines, interferon-gamma (IFN-gamma), monocyte chemotactic protein-1 (MCP-1) and tumour necrosis factor-alpha (TNF-alpha). gamma-Linolenic Acid 66-69 C-C motif chemokine ligand 2 Homo sapiens 209-214 9849654-1 1998 This study was undertaken to assess whether gamma-linolenic acid (GLA) in the form of evening primrose oil (EPO) could affect rat serum cytokines, interferon-gamma (IFN-gamma), monocyte chemotactic protein-1 (MCP-1) and tumour necrosis factor-alpha (TNF-alpha). evening primrose oil 94-106 C-C motif chemokine ligand 2 Homo sapiens 177-207 9849654-3 1998 In the presence of GLA, the IFN-gamma and MCP-1 levels were significantly decreased in contrast to the control group of TNF-alpha, which was significantly stimulated. gamma-Linolenic Acid 19-22 C-C motif chemokine ligand 2 Homo sapiens 42-47 9849654-5 1998 The observations indicate that GLA may modulate the level of serum IFN-gamma, MCP-1 and TNF-alpha, which may be a worthwhile line of treatment in certain human diseases. gamma-Linolenic Acid 31-34 C-C motif chemokine ligand 2 Homo sapiens 78-83 9740146-10 1998 TPA (10 nmol/L) also stimulated the production of IL-6 and IL-8 by these cells, but inhibited that of monocyte chemoattractant protein-1. Tetradecanoylphorbol Acetate 0-3 C-C motif chemokine ligand 2 Homo sapiens 102-136 9831176-9 1998 Dexamethasone partially inhibited the cytokine-induced release of MCP-1 and IL-8 and the expression of ICAM-1, CD40, and HLA class II molecules by human bronchial epithelial cells. Dexamethasone 0-13 C-C motif chemokine ligand 2 Homo sapiens 66-71 9710230-4 1998 TIL matrix invasion elicited by TC is inhibited by the addition of neutralizing antisera specific for IL-8 and MCP-1, demonstrating the direct relationship between chemokine release by TC and TIL invasion. Technetium 185-187 C-C motif chemokine ligand 2 Homo sapiens 111-116 9690225-9 1998 RESULTS: Compared to the control group, PBMC from uremic patients on conservative therapy and treated by CU showed a clear reduction in the cytokine release, while PMMA and PA membranes were able to normalize IL-6, IL-8 and MCP-1 protein concentration, which had been reduced by CU treatment. cuprammonium cellulose 105-107 C-C motif chemokine ligand 2 Homo sapiens 224-229 9723671-0 1998 Diisocyanate antigen-enhanced production of monocyte chemoattractant protein-1, IL-8, and tumor necrosis factor-alpha by peripheral mononuclear cells of workers with occupational asthma. 4,4'-diphenylmethane diisocyanate 0-12 C-C motif chemokine ligand 2 Homo sapiens 44-78 9723671-3 1998 OBJECTIVE: PBMCs of diisocyanate-exposed workers were tested in vitro for diisocyanate antigen-specific enhancement of monocyte chemoattractant protein-1 (MCP-1), monocyte chemoattractant protein-3 (MCP-3), macrophage inflammatory protein-1alpha, RANTES, IL-8, and T-cell cytokines that could play a regulatory role in chemokine synthesis (IL-4, IL-5, IFN-gamma, and TNF-alpha. 4,4'-diphenylmethane diisocyanate 74-86 C-C motif chemokine ligand 2 Homo sapiens 119-153 9723671-6 1998 RESULTS: PBMCs of workers with DOA showed significantly enhanced secretion for MCP-1 compared with diisocyanate-exposed asymptomatic workers (P < .05). dioctyl adipate 31-34 C-C motif chemokine ligand 2 Homo sapiens 79-84 9723671-6 1998 RESULTS: PBMCs of workers with DOA showed significantly enhanced secretion for MCP-1 compared with diisocyanate-exposed asymptomatic workers (P < .05). 4,4'-diphenylmethane diisocyanate 99-111 C-C motif chemokine ligand 2 Homo sapiens 79-84 9723671-10 1998 CONCLUSION: Antigen stimulation of MCP-1 and TNF-alpha suggest that diisocyanate-specific cellular immune reactions result in activation of macrophages, which may be important in the pathogenesis of DOA. 4,4'-diphenylmethane diisocyanate 68-80 C-C motif chemokine ligand 2 Homo sapiens 35-40 9690225-9 1998 RESULTS: Compared to the control group, PBMC from uremic patients on conservative therapy and treated by CU showed a clear reduction in the cytokine release, while PMMA and PA membranes were able to normalize IL-6, IL-8 and MCP-1 protein concentration, which had been reduced by CU treatment. Polymethyl Methacrylate 164-168 C-C motif chemokine ligand 2 Homo sapiens 224-229 9690225-9 1998 RESULTS: Compared to the control group, PBMC from uremic patients on conservative therapy and treated by CU showed a clear reduction in the cytokine release, while PMMA and PA membranes were able to normalize IL-6, IL-8 and MCP-1 protein concentration, which had been reduced by CU treatment. Nylons 173-175 C-C motif chemokine ligand 2 Homo sapiens 224-229 9581871-3 1998 Copper-induced proliferation of endothelial cells is not inhibited by 10% fetal bovine serum or by the presence of antibodies against a variety of angiogenic, growth, and chemotactic factors including angiogenin, fibroblast growth factors, epidermal growth factor, platelet-derived growth factor, tumor necrosis factor-alpha, transforming growth factor-beta, macrophage/monocyte chemotactic and activating factor, and macrophage inflammatory protein-1alpha. Copper 0-6 C-C motif chemokine ligand 2 Homo sapiens 370-412 9687567-8 1998 Of the mRNAs tested, only those encoding monocyte chemotactic protein-1 (approximately 2-fold over basal) and interleukin-8 (approximately 6-fold over basal) are induced by histamine; both of these responses are suppressed by CsA and FK506. Histamine 173-182 C-C motif chemokine ligand 2 Homo sapiens 41-71 9687567-8 1998 Of the mRNAs tested, only those encoding monocyte chemotactic protein-1 (approximately 2-fold over basal) and interleukin-8 (approximately 6-fold over basal) are induced by histamine; both of these responses are suppressed by CsA and FK506. Cyclosporine 226-229 C-C motif chemokine ligand 2 Homo sapiens 41-71 9687567-8 1998 Of the mRNAs tested, only those encoding monocyte chemotactic protein-1 (approximately 2-fold over basal) and interleukin-8 (approximately 6-fold over basal) are induced by histamine; both of these responses are suppressed by CsA and FK506. Tacrolimus 234-239 C-C motif chemokine ligand 2 Homo sapiens 41-71 9723388-0 1998 Additive effect of cyclosporine and low density lipoproteins on transforming growth factor-beta 1 and monocyte chemotactic protein-1 expression in human mesangial cells. Cyclosporine 19-31 C-C motif chemokine ligand 2 Homo sapiens 102-132 9670957-0 1998 The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor. Tyrosine 84-92 C-C motif chemokine ligand 2 Homo sapiens 14-44 9670957-3 1998 Using the Mono Mac 1 monocytic cell line, we show that monocyte chemotactic protein 1 (MCP-1) triggers activation of the Janus kinase 2 (JAK2)/STAT3 pathway and CCR2 receptor tyrosine phosphorylation. Tyrosine 175-183 C-C motif chemokine ligand 2 Homo sapiens 55-85 9670957-3 1998 Using the Mono Mac 1 monocytic cell line, we show that monocyte chemotactic protein 1 (MCP-1) triggers activation of the Janus kinase 2 (JAK2)/STAT3 pathway and CCR2 receptor tyrosine phosphorylation. Tyrosine 175-183 C-C motif chemokine ligand 2 Homo sapiens 87-92 9670957-7 1998 In contrast, when a CCR2B Tyr139Phe mutant is expressed in HEK293 cells, it is not phosphorylated in tyrosine and triggers neither JAK2/STAT3 activation nor Ca2+ mobilization in response to MCP-1. tyr139phe 26-35 C-C motif chemokine ligand 2 Homo sapiens 190-195 9688530-3 1998 We have found that an intercysteine first loop peptide encompassing amino acids 13-35 inhibits MCP-1 binding and chemotactic activity, while peptides representing the amino-terminus (amino acids 1-10), second loop (amino acids 37-51), and carboxy-terminus (amino acids 56-71) of MCP-1 have no effect. intercysteine 22-35 C-C motif chemokine ligand 2 Homo sapiens 95-100 9688530-3 1998 We have found that an intercysteine first loop peptide encompassing amino acids 13-35 inhibits MCP-1 binding and chemotactic activity, while peptides representing the amino-terminus (amino acids 1-10), second loop (amino acids 37-51), and carboxy-terminus (amino acids 56-71) of MCP-1 have no effect. intercysteine 22-35 C-C motif chemokine ligand 2 Homo sapiens 279-284 9688530-4 1998 In addition, we have found that cyclization of the first loop peptide by disulfide linkage and blocking the C-terminus of the peptide by amidation increases the activity of this peptide to block MCP-1 binding and chemotaxis. Disulfides 73-82 C-C motif chemokine ligand 2 Homo sapiens 195-200 9633934-5 1998 We present evidence that a proteasome inhibitor, N-acetyl-leucinyl-leucinyl-norleucinal (norLeu), and the protease inhibitor tosyl-Phe-chloromethylketone (TPCK) block IL-1beta induction of MCP-1 protein expression. tosyl-phe-chloromethylketone 125-153 C-C motif chemokine ligand 2 Homo sapiens 189-194 9627299-17 1998 CONCLUSION(S): These findings suggest that MCP-1 may have antineoplastic activity in leiomyomata and that sex steroids may be exerting their growth stimulatory effect in leiomyomata through down-regulation of MCP-1. Steroids 110-118 C-C motif chemokine ligand 2 Homo sapiens 209-214 9533939-11 1998 Dexamethasone significantly reduces MCP-1 production and mRNA levels also in part through effects on transcript stability. Dexamethasone 0-13 C-C motif chemokine ligand 2 Homo sapiens 36-41 9602633-7 1998 DEX caused dose dependent inhibition of IL-1 induced IL-8 (p < 0.001) and MCP-1 (p < 0.05) secretion and mRNA expression at all concentrations of rIL-1 beta. Dexamethasone 0-3 C-C motif chemokine ligand 2 Homo sapiens 77-82 9561924-6 1998 Moreover, anti-MCP-1 and anti-TGF antibodies showed an additive inhibitory effect on TC-120IP-induced migration of monocytes across a filter. tc-120ip 85-93 C-C motif chemokine ligand 2 Homo sapiens 15-20 9760814-8 1998 The serum level of MCP-1 showed a correlation with concentration of triglycerides in both transplant patient groups. Triglycerides 68-81 C-C motif chemokine ligand 2 Homo sapiens 19-24 9760814-13 1998 MCP-1 levels were particularly high (> 2000 pg/mg creatinine) in patients with enhanced dynamics of ch.g.r. Creatinine 53-63 C-C motif chemokine ligand 2 Homo sapiens 0-5 9760814-14 1998 The MCP-1 levels were higher in those patients whose biopsies described cellular infiltration (1385 + 820 pg/mg creatinine vs 680 + 280 pg/mg creatinine). Creatinine 112-122 C-C motif chemokine ligand 2 Homo sapiens 4-9 9760814-14 1998 The MCP-1 levels were higher in those patients whose biopsies described cellular infiltration (1385 + 820 pg/mg creatinine vs 680 + 280 pg/mg creatinine). Creatinine 142-152 C-C motif chemokine ligand 2 Homo sapiens 4-9 9760814-15 1998 The urine level of MCP-1 showed a correlation with concentration of serum creatinine, cholesterol, level of proteinuria and with arterial pressure in ch.g.r. Creatinine 74-84 C-C motif chemokine ligand 2 Homo sapiens 19-24 9760814-15 1998 The urine level of MCP-1 showed a correlation with concentration of serum creatinine, cholesterol, level of proteinuria and with arterial pressure in ch.g.r. Cholesterol 86-97 C-C motif chemokine ligand 2 Homo sapiens 19-24 9501202-4 1998 In this report, we show that MCP-1 binding to the CCR2 receptor in Mono Mac 1 cells promotes the rapid desensitization of MCP-1-induced calcium flux responses. Calcium 136-143 C-C motif chemokine ligand 2 Homo sapiens 29-34 9501202-4 1998 In this report, we show that MCP-1 binding to the CCR2 receptor in Mono Mac 1 cells promotes the rapid desensitization of MCP-1-induced calcium flux responses. Calcium 136-143 C-C motif chemokine ligand 2 Homo sapiens 122-127 9537339-8 1998 The increased MCP-1 levels in CHF were correlated with increased monocyte activity reflected in an enhancing effect of serum from CHF patients on O2-generation in monocytes, which was inhibited by neutralizing antibodies against MCP-1. Oxygen 146-148 C-C motif chemokine ligand 2 Homo sapiens 14-19 9537339-8 1998 The increased MCP-1 levels in CHF were correlated with increased monocyte activity reflected in an enhancing effect of serum from CHF patients on O2-generation in monocytes, which was inhibited by neutralizing antibodies against MCP-1. Oxygen 146-148 C-C motif chemokine ligand 2 Homo sapiens 229-234 9602633-10 1998 CONCLUSIONS: DEX is a potent inhibitor of OF IL-8 and MCP-1. Dexamethasone 13-16 C-C motif chemokine ligand 2 Homo sapiens 54-59 9407069-10 1997 While TNFalpha induced both RANTES and MCP-1, H2O2 induced only MCP-1. Hydrogen Peroxide 46-50 C-C motif chemokine ligand 2 Homo sapiens 64-69 9469447-8 1998 The induction of endothelial cells by LPS to transcribe and release monocyte chemoattractant protein-1 (MCP-1) was significantly reduced by LPG (40-65%). lipophosphonoglycan 140-143 C-C motif chemokine ligand 2 Homo sapiens 68-102 9469447-8 1998 The induction of endothelial cells by LPS to transcribe and release monocyte chemoattractant protein-1 (MCP-1) was significantly reduced by LPG (40-65%). lipophosphonoglycan 140-143 C-C motif chemokine ligand 2 Homo sapiens 104-109 9469447-9 1998 LPG treatment of nonactivated endothelial cells also suppressed by 55 to 75% the monocyte migration triggered by a MCP-1 chemoattractant gradient, and coincubation of LPG with neutralizing mAb abrogated the inhibitory activity. lipophosphonoglycan 0-3 C-C motif chemokine ligand 2 Homo sapiens 115-120 9537772-10 1998 Finally, cetirizine, but not hydrocortisone, inhibited the release of MCP-1 and RANTES from IFNgamma-stimulated keratinocytes. Cetirizine 9-19 C-C motif chemokine ligand 2 Homo sapiens 70-75 9472473-6 1998 RESULTS: GHSA at 500 micrograms/ml concentration induced a significant increase in keratocyte IL-8 and MCP-1 protein secretion over the 24 h time course. ghsa 9-13 C-C motif chemokine ligand 2 Homo sapiens 103-108 9472473-9 1998 The levels of GHSA (500 micrograms/ml)-induced keratocyte IL-8 and MCP-1 expression were similar to that induced by IL-1 beta (0.02 ng/ml) and TNF-alpha (2.0 ng/ml). ghsa 14-18 C-C motif chemokine ligand 2 Homo sapiens 67-72 9449504-6 1998 Furthermore, MCP-1 production was also inhibited by DEX. Dexamethasone 52-55 C-C motif chemokine ligand 2 Homo sapiens 13-18 9520946-6 1998 In contrast to IL-8, the TNF-alpha-induced HRPE MCP-1 gene expression was only slightly enhanced by GHSA. ghsa 100-104 C-C motif chemokine ligand 2 Homo sapiens 48-53 9518454-3 1998 SDS-PAGE and Western blot revealed two immunoreactive MCP-1 species at 15 and 8.5 kDa designated MCP-1H and MCP-1L, respectively; both were purified by cation-exchange chromatography. Sodium Dodecyl Sulfate 0-3 C-C motif chemokine ligand 2 Homo sapiens 54-59 9434794-6 1998 After exposure of human monocytes to HOCl-LDL, it was found that mRNA and protein of the chemokine IL-8 was strongly induced, while the chemokine MCP-1 was not. Hypochlorous Acid 37-41 C-C motif chemokine ligand 2 Homo sapiens 146-151 9609459-0 1998 A high glucose concentration stimulates the expression of monocyte chemotactic peptide 1 in human mesangial cells. Glucose 7-14 C-C motif chemokine ligand 2 Homo sapiens 58-88 9609459-3 1998 More than a 50% increase in the MCP-1 protein production was observed in MCs cultured in high-glucose medium (450 mg/dl) as compared to normal glucose (100 mg/dl; 1,496 +/- 75 vs. 966 +/- 15 pg/ml after 24 h, 1,910 +/- 93 vs. 1,250 +/- 55 pg/ml after 48 h). Glucose 94-101 C-C motif chemokine ligand 2 Homo sapiens 32-37 9609459-3 1998 More than a 50% increase in the MCP-1 protein production was observed in MCs cultured in high-glucose medium (450 mg/dl) as compared to normal glucose (100 mg/dl; 1,496 +/- 75 vs. 966 +/- 15 pg/ml after 24 h, 1,910 +/- 93 vs. 1,250 +/- 55 pg/ml after 48 h). Glucose 143-150 C-C motif chemokine ligand 2 Homo sapiens 32-37 9609459-4 1998 Semiquantitative PCR showed that phorbol myristate acetate (100 nM) increased the ratio of PCR products for MCP-1 to housekeeping gene glyceraldehyde-3-phosphate dehydrogenase on densitometric results at 24 h by 2.7-fold, which was prevented by calphostin C (200 nM) pretreatment. Tetradecanoylphorbol Acetate 33-58 C-C motif chemokine ligand 2 Homo sapiens 108-113 9609459-4 1998 Semiquantitative PCR showed that phorbol myristate acetate (100 nM) increased the ratio of PCR products for MCP-1 to housekeeping gene glyceraldehyde-3-phosphate dehydrogenase on densitometric results at 24 h by 2.7-fold, which was prevented by calphostin C (200 nM) pretreatment. calphostin C 245-257 C-C motif chemokine ligand 2 Homo sapiens 108-113 9609459-7 1998 These findings demonstrate that high glucose can directly increase MCP-1 expression in MCs, which may contribute to monocyte infiltration in diabetic nephropathy, and this is regulated by protein kinase C. Glucose 37-44 C-C motif chemokine ligand 2 Homo sapiens 67-72 9373254-10 1997 MC-sup and HMC-1-sup induced chemotaxis in blood monocytes (Mo) (control: 100% +/- 12% v 2-hour-MC-sup: 463% +/- 38% v HMC-1-sup: 532% +/- 12%), and a monoclonal antibody (MoAb) to MCP-1 (but not MoAb to IL-8) inhibited Mo-chemotaxis induced by MC-sup or HMC-1-sup (39% to 55% inhibition, P < .05). mc-sup 0-6 C-C motif chemokine ligand 2 Homo sapiens 181-186 9388261-8 1997 The binding of (p65)2 and/or c-Rel/p65 to the A2 probe was also detected from 12-o-tetradecanoylphorbol 13-acetate-stimulated HeLa, HOS, and A172 cells in which expression of MCP-1 mRNA was elevated. Tetradecanoylphorbol Acetate 78-114 C-C motif chemokine ligand 2 Homo sapiens 175-180 9373254-10 1997 MC-sup and HMC-1-sup induced chemotaxis in blood monocytes (Mo) (control: 100% +/- 12% v 2-hour-MC-sup: 463% +/- 38% v HMC-1-sup: 532% +/- 12%), and a monoclonal antibody (MoAb) to MCP-1 (but not MoAb to IL-8) inhibited Mo-chemotaxis induced by MC-sup or HMC-1-sup (39% to 55% inhibition, P < .05). hmc-1-sup 11-20 C-C motif chemokine ligand 2 Homo sapiens 181-186 9292787-0 1997 Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha in cultured human synovial cells. Quercetin 0-9 C-C motif chemokine ligand 2 Homo sapiens 71-105 9548499-6 1997 Moreover, both MCP-1 and the agonist mAb trigger specific B cell migration via a PTX-sensitive mechanism, indicating the presence of a functional CCR2 receptor in these cells. ptx 81-84 C-C motif chemokine ligand 2 Homo sapiens 15-20 9354625-9 1997 The endothelial cell binding sites for IL-8, RANTES, and MCP-1 were deduced to be glycosaminoglycans since competition assays showed the biphasic curves and micromolar IC50 values seen in studies with immobilized heparin, and mRNA for known chemokine receptors was not detected. Glycosaminoglycans 82-100 C-C motif chemokine ligand 2 Homo sapiens 57-62 9354625-9 1997 The endothelial cell binding sites for IL-8, RANTES, and MCP-1 were deduced to be glycosaminoglycans since competition assays showed the biphasic curves and micromolar IC50 values seen in studies with immobilized heparin, and mRNA for known chemokine receptors was not detected. Heparin 213-220 C-C motif chemokine ligand 2 Homo sapiens 57-62 9354625-12 1997 Removal of glycosaminoglycans from CHO cells expressing chemokine receptors CXCR1, CCR1, or CCR2 resulted in 40-70% decreases in the binding of RANTES, MCP-1, IL-8, and MIP-1alpha. Glycosaminoglycans 11-29 C-C motif chemokine ligand 2 Homo sapiens 152-157 9350917-7 1997 Moreover, lovastatin inhibited CD11b-dependent adhesiveness to fixed endothelium of unstimulated monocytes or monocytes stimulated with monocyte chemotactic protein 1. Lovastatin 10-20 C-C motif chemokine ligand 2 Homo sapiens 136-166 9344869-0 1997 The inhibition of synthesis of a beta-chemokine, monocyte chemotactic protein-1 (MCP-1) by progesterone. Progesterone 91-103 C-C motif chemokine ligand 2 Homo sapiens 49-79 9344869-0 1997 The inhibition of synthesis of a beta-chemokine, monocyte chemotactic protein-1 (MCP-1) by progesterone. Progesterone 91-103 C-C motif chemokine ligand 2 Homo sapiens 81-86 9344869-7 1997 A synthetic progestin (medroxyprogesterone acetate) inhibits choriodecidual cell production of MCP-1; this inhibition was reversed by the antiprogestin RU486. Medroxyprogesterone Acetate 23-50 C-C motif chemokine ligand 2 Homo sapiens 95-100 9344869-7 1997 A synthetic progestin (medroxyprogesterone acetate) inhibits choriodecidual cell production of MCP-1; this inhibition was reversed by the antiprogestin RU486. Mifepristone 152-157 C-C motif chemokine ligand 2 Homo sapiens 95-100 9344869-8 1997 MCP-1 release from T47D cells can be stimulated by IL-1 and this production is inhibited by progesterone with an ED50 of less than 10(-9) M. A glucocorticoid (dexamethasone) had no effect on MCP-1 release in this system, suggesting that glucocorticoid receptor-mediated responses were impaired under these conditions. Progesterone 92-104 C-C motif chemokine ligand 2 Homo sapiens 191-196 9344869-8 1997 MCP-1 release from T47D cells can be stimulated by IL-1 and this production is inhibited by progesterone with an ED50 of less than 10(-9) M. A glucocorticoid (dexamethasone) had no effect on MCP-1 release in this system, suggesting that glucocorticoid receptor-mediated responses were impaired under these conditions. Dexamethasone 159-172 C-C motif chemokine ligand 2 Homo sapiens 191-196 9378985-6 1997 We further show that MCP-1-induced transendothelial chemotaxis of PBMC was inhibited by sustained activation of LFA-1 with Mn2+ or a stimulatory mAb to beta 2. Manganese(2+) 123-127 C-C motif chemokine ligand 2 Homo sapiens 21-26 9405974-3 1997 In the present study, we found that 10 microM cilostazol, a cAMP phosphodiesterase inhibitor, increased the intracellular cAMP content by a twenty-five times of the basal level and resulted in the reduction of basal MCP-1 release by 41% from 168 +/- 11 ng/24 hr/mg protein to 99 +/- 14 ng/24 hr/mg protein (P < 0.001) from cultured human umbilical vein endothelial cells. Cilostazol 46-56 C-C motif chemokine ligand 2 Homo sapiens 216-221 9292787-6 1997 RESULTS: Addition of quercetin suppressed TNF-alpha induced increase in the mRNA for IL-8 and MCP-1 in a dose dependent manner. Quercetin 21-30 C-C motif chemokine ligand 2 Homo sapiens 94-99 9292787-8 1997 H2O2 mediated induction of IL-8 and MCP-1 genes was also inhibited by quercetin. Hydrogen Peroxide 0-4 C-C motif chemokine ligand 2 Homo sapiens 36-41 9292787-8 1997 H2O2 mediated induction of IL-8 and MCP-1 genes was also inhibited by quercetin. Quercetin 70-79 C-C motif chemokine ligand 2 Homo sapiens 36-41 9292787-10 1997 CONCLUSION: Quercetin suppresses TNF-alpha mediated stimulation of IL-8 and MCP-1 expression, at least in part, by inhibiting the activation of NF-kappa B. Quercetin 12-21 C-C motif chemokine ligand 2 Homo sapiens 76-81 9353321-7 1997 Chelation of intracellular calcium and inhibition of protein kinase C block the induction of TF by MCP-1, suggesting that in SMC it is mediated by activation of phospholipase C. SMC bind MCP-1 with a Kd similar to that previously reported for macrophages. Calcium 27-34 C-C motif chemokine ligand 2 Homo sapiens 99-104 9353321-7 1997 Chelation of intracellular calcium and inhibition of protein kinase C block the induction of TF by MCP-1, suggesting that in SMC it is mediated by activation of phospholipase C. SMC bind MCP-1 with a Kd similar to that previously reported for macrophages. Calcium 27-34 C-C motif chemokine ligand 2 Homo sapiens 187-192 9369424-4 1997 Cytotoxicity experiments with a MTT test using MCP-1-stimulated monocytes against two human myeloid leukemic cell lines showed no increase in cell death compared to unstimulated monocytes. monooxyethylene trimethylolpropane tristearate 32-35 C-C motif chemokine ligand 2 Homo sapiens 47-52 9337212-0 1997 Platelet-derived growth factor-stimulated superoxide anion production modulates activation of transcription factor NF-kappaB and expression of monocyte chemoattractant protein 1 in human aortic smooth muscle cells. Superoxides 42-58 C-C motif chemokine ligand 2 Homo sapiens 143-177 9337212-8 1997 Superoxide dismutase as well as iodonium diphenyl, Ro 31-8220, and wortmannin attenuated PDGF-AB-induced activation of NF-kappaB and expression of MCP-1 mRNA. diphenyliodonium 32-49 C-C motif chemokine ligand 2 Homo sapiens 147-152 9337212-8 1997 Superoxide dismutase as well as iodonium diphenyl, Ro 31-8220, and wortmannin attenuated PDGF-AB-induced activation of NF-kappaB and expression of MCP-1 mRNA. Wortmannin 67-77 C-C motif chemokine ligand 2 Homo sapiens 147-152 9337212-11 1997 This PDGF-induced O2.- production may be involved in vascular lesion formation by mediating, at least in part, NF-kappaB activation and MCP-1 induction. Superoxides 18-20 C-C motif chemokine ligand 2 Homo sapiens 136-141 9352362-3 1997 Here we show that human recombinant monocyte chemotactic protein (MCP)-1 (10 ng/50 microliters) induces, after 4 h, an inflammatory vascular permeability and cellular extravasation reaction, determined by Evan"s blue dye (1% in saline) injected into the tail vein of the rat, when injected intradermally in the rat skin. Sodium Chloride 228-234 C-C motif chemokine ligand 2 Homo sapiens 36-72 9336350-11 1997 Addition of either MCP-1 or MCP-3 produced a concentration-dependent elevation of intracellular calcium with a maximun response 2-fold higher than that seen with RANTES or MIP-1alpha. Calcium 96-103 C-C motif chemokine ligand 2 Homo sapiens 19-24 9287323-5 1997 Mutation of highly conserved cysteines in the amino-terminal domain and third extracellular loop of CCR2, but not in the fusion protein, resulted in a dramatic loss of MCP-1 binding, suggesting the existence of a critical intramolecular disulfide bond that positions the amino-terminal protein for ligand interaction. Cysteine 29-38 C-C motif chemokine ligand 2 Homo sapiens 168-173 9287323-5 1997 Mutation of highly conserved cysteines in the amino-terminal domain and third extracellular loop of CCR2, but not in the fusion protein, resulted in a dramatic loss of MCP-1 binding, suggesting the existence of a critical intramolecular disulfide bond that positions the amino-terminal protein for ligand interaction. Disulfides 237-246 C-C motif chemokine ligand 2 Homo sapiens 168-173 9292787-0 1997 Quercetin, a bioflavonoid, inhibits the induction of interleukin 8 and monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha in cultured human synovial cells. Flavonoids 13-25 C-C motif chemokine ligand 2 Homo sapiens 71-105 9264504-8 1997 The induced expression of MCP-1 and activation of NFkappaB were reduced by previous exposure of the SMCs to the NO donor DETA-NONOate (100 micromol/L) (P<.05). 2,2'-(hydroxynitrosohydrazono)bis-ethanamine 121-133 C-C motif chemokine ligand 2 Homo sapiens 26-31 9263137-3 1997 RESULTS: In MNC and synovial fibroblast cultures dexamethasone, GSTM, and PGE2 most markedly downregulated spontaneous and/or cytokine stimulated production of IL-1 beta, IL-14a, IL-8, and MCP-1, whereas sTNFR shedding was not affected. Dexamethasone 49-62 C-C motif chemokine ligand 2 Homo sapiens 189-194 9201021-0 1997 Cyclic strain-induced monocyte chemotactic protein-1 gene expression in endothelial cells involves reactive oxygen species activation of activator protein 1. Reactive Oxygen Species 99-122 C-C motif chemokine ligand 2 Homo sapiens 22-52 9263137-3 1997 RESULTS: In MNC and synovial fibroblast cultures dexamethasone, GSTM, and PGE2 most markedly downregulated spontaneous and/or cytokine stimulated production of IL-1 beta, IL-14a, IL-8, and MCP-1, whereas sTNFR shedding was not affected. Gold Sodium Thiomalate 64-68 C-C motif chemokine ligand 2 Homo sapiens 189-194 9263137-3 1997 RESULTS: In MNC and synovial fibroblast cultures dexamethasone, GSTM, and PGE2 most markedly downregulated spontaneous and/or cytokine stimulated production of IL-1 beta, IL-14a, IL-8, and MCP-1, whereas sTNFR shedding was not affected. Dinoprostone 74-78 C-C motif chemokine ligand 2 Homo sapiens 189-194 9201021-5 1997 The potential role of ROS in strain-induced MCP-1 expression was investigated. Reactive Oxygen Species 22-25 C-C motif chemokine ligand 2 Homo sapiens 44-49 9201021-7 1997 ECs under strain or pretreated with either H2O2 or xanthine oxidase/hypoxanthine induced MCP-1 expression. Hydrogen Peroxide 43-47 C-C motif chemokine ligand 2 Homo sapiens 89-94 9201021-7 1997 ECs under strain or pretreated with either H2O2 or xanthine oxidase/hypoxanthine induced MCP-1 expression. Hypoxanthine 68-80 C-C motif chemokine ligand 2 Homo sapiens 89-94 9201021-8 1997 Strain- or oxidant-induced MCP-1 mRNA levels could be inhibited by treating ECs with catalase or antioxidant N-acetyl-cysteine (NAC). Acetylcysteine 109-126 C-C motif chemokine ligand 2 Homo sapiens 27-32 9201021-8 1997 Strain- or oxidant-induced MCP-1 mRNA levels could be inhibited by treating ECs with catalase or antioxidant N-acetyl-cysteine (NAC). Acetylcysteine 128-131 C-C motif chemokine ligand 2 Homo sapiens 27-32 9201021-9 1997 Functional analysis of MCP-1 promoter and site-specific mutations indicates that the proximal tissue plasminogen activator-responsive element (TRE) in the -60-bp promoter region is sufficient for strain or H2O2 inducibility. Hydrogen Peroxide 206-210 C-C motif chemokine ligand 2 Homo sapiens 23-28 9201021-12 1997 These results clearly indicate that cyclic strain inducibility of MCP-1 in ECs uses the interaction of AP-1 proteins with TRE sites via the elevation of intracellular ROS levels in strained ECs. Reactive Oxygen Species 167-170 C-C motif chemokine ligand 2 Homo sapiens 66-71 9231036-11 1997 Anti-human MCP-1 neutralizing antibody inhibited the migration of THP-1 cells stimulated by m-ox-LDL. m-ox-ldl 92-100 C-C motif chemokine ligand 2 Homo sapiens 11-16 9176395-9 1997 Preincubation of HUVECs with pyrrolidine dithiocarbamate prevented MAC-induced increases in IL-8 and MCP-1 mRNA concentrations and protein secretion. pyrrolidine dithiocarbamic acid 29-56 C-C motif chemokine ligand 2 Homo sapiens 101-106 9176445-8 1997 RESULT(S): The median concentration of monocyte chemotactic protein-1 in PF of control women was 137 pg/mL (conversion factor to SI unit, 0.115; range, 12 to 418 pg/mL); that of women with moderate endometriosis was 205 pg/mL (range 65 to 6,000 pg/mL); and that of those with severe endometriosis was 1,165 pg/mL (0 to 2,602 pg/mL). Silicon 129-131 C-C motif chemokine ligand 2 Homo sapiens 39-69 9222645-4 1997 The increment of MCP-1 mRNA content was positively correlated with not only HbA1c (r = 0.58, p < 0.0001) but also lysophosphatidylcholine (LPC) content in the lipoprotein (r = 0.46, p < 0.005) and was negatively correlated with diene formation lag time as a marker of oxidizability of the lipoprotein (r = -0.33, p < 0.05). Lysophosphatidylcholines 117-140 C-C motif chemokine ligand 2 Homo sapiens 17-22 9222645-4 1997 The increment of MCP-1 mRNA content was positively correlated with not only HbA1c (r = 0.58, p < 0.0001) but also lysophosphatidylcholine (LPC) content in the lipoprotein (r = 0.46, p < 0.005) and was negatively correlated with diene formation lag time as a marker of oxidizability of the lipoprotein (r = -0.33, p < 0.05). Lysophosphatidylcholines 142-145 C-C motif chemokine ligand 2 Homo sapiens 17-22 9222645-4 1997 The increment of MCP-1 mRNA content was positively correlated with not only HbA1c (r = 0.58, p < 0.0001) but also lysophosphatidylcholine (LPC) content in the lipoprotein (r = 0.46, p < 0.005) and was negatively correlated with diene formation lag time as a marker of oxidizability of the lipoprotein (r = -0.33, p < 0.05). diene 234-239 C-C motif chemokine ligand 2 Homo sapiens 17-22 9222645-5 1997 Treatments of the cells with either 50 mumol/l probucol, 50 mumol/l alpha-tocopherol, or 0.1 mmol/l deferoxamine suppressed the increase in MCP-1 mRNA content induced by diabetic lipoproteins, respectively. Probucol 47-55 C-C motif chemokine ligand 2 Homo sapiens 140-145 9222645-5 1997 Treatments of the cells with either 50 mumol/l probucol, 50 mumol/l alpha-tocopherol, or 0.1 mmol/l deferoxamine suppressed the increase in MCP-1 mRNA content induced by diabetic lipoproteins, respectively. alpha-Tocopherol 68-84 C-C motif chemokine ligand 2 Homo sapiens 140-145 9222645-5 1997 Treatments of the cells with either 50 mumol/l probucol, 50 mumol/l alpha-tocopherol, or 0.1 mmol/l deferoxamine suppressed the increase in MCP-1 mRNA content induced by diabetic lipoproteins, respectively. Deferoxamine 100-112 C-C motif chemokine ligand 2 Homo sapiens 140-145 9040477-5 1997 RESULTS: Although DEX (10(-8) to 10(-6) M) inhibited IL-1 beta-stimulated MCP-1 and IL-8 production, it did not inhibit TNF-alpha-stimulated chemokine secretion. Dexamethasone 18-21 C-C motif chemokine ligand 2 Homo sapiens 74-79 9228919-8 1997 By Postburn Day 2, basal layer keratinocytes at the edges of the wound had upregulated MCP-1 message; the increased signal persisted in the rate pegs deep in the dermal wound bed through 49 days postinjury. pegs 145-149 C-C motif chemokine ligand 2 Homo sapiens 87-92 9130630-3 1997 Eosinophils generated immunoreactive MCP-1 in response to such diverse stimuli as C5a, formyl-methionyl-leucyl-phenylalanine (FMLP) and ionomycin, but MCP-1 production was not induced by interleukin (IL)-1 or tumor necrosis factor-alpha. Ionomycin 136-145 C-C motif chemokine ligand 2 Homo sapiens 37-42 9130630-4 1997 C5a- and FMLP-induced eosinophil MCP-1 production was absolutely dependent on pretreatment with cytochalasin B. Cytochalasin B 96-110 C-C motif chemokine ligand 2 Homo sapiens 33-38 9126706-5 1997 Incubation of mesangial cells with the oxidizing agents diamide or hydrogen peroxide did not upregulate MCP-1 gene expression, and prevented IL-1 induction of MCP-1 mRNA. Diamide 56-63 C-C motif chemokine ligand 2 Homo sapiens 159-164 9126706-5 1997 Incubation of mesangial cells with the oxidizing agents diamide or hydrogen peroxide did not upregulate MCP-1 gene expression, and prevented IL-1 induction of MCP-1 mRNA. Hydrogen Peroxide 67-84 C-C motif chemokine ligand 2 Homo sapiens 159-164 9126706-7 1997 Non-oxidative depletion of intracellular glutathione also attenuated the effects of IL-1 on MCP-1 expression. Glutathione 41-52 C-C motif chemokine ligand 2 Homo sapiens 92-97 9040477-9 1997 CONCLUSIONS: Although DEX and CSA inhibit HRPE MCP-1 and IL-8 secretion, this is dependent on whether the inducing inflammatory mediator is IL-1 beta or TNF-alpha. Dexamethasone 22-25 C-C motif chemokine ligand 2 Homo sapiens 47-52 9040478-8 1997 Smaller, but significant, increases in IL-8 and MCP-1 resulted from CM phorbol myristic acid-stimulated T-lymphocytes. phorbol-12-myristate 71-92 C-C motif chemokine ligand 2 Homo sapiens 48-53 9042155-8 1997 Quiescent human umbilical vein endothelial cells incubated with either H2O2 or activated neutrophils secreted MCP-1. Hydrogen Peroxide 71-75 C-C motif chemokine ligand 2 Homo sapiens 110-115 9080384-8 1997 There was a correlation between follicular fluid MCP-1 levels and follicular fluid or serum progesterone levels (r = 0.21, P = 0.02; r = 0.29, P = 0.03, respectively). Progesterone 92-104 C-C motif chemokine ligand 2 Homo sapiens 49-54 9042155-10 1997 These in vivo data, coupled with in vitro data that indicate that both catalase-sensitive reagent H2O2 and neutrophil-derived reactive oxygen intermediates (ie, H2O2) can induce MCP-1 secretion by human umbilical vein endothelial cells, support the hypothesis that neutrophils and neutrophil-derived products (H2O2) influence granuloma formation through induction of local MCP-1 expression. Hydrogen Peroxide 98-102 C-C motif chemokine ligand 2 Homo sapiens 178-183 9042155-10 1997 These in vivo data, coupled with in vitro data that indicate that both catalase-sensitive reagent H2O2 and neutrophil-derived reactive oxygen intermediates (ie, H2O2) can induce MCP-1 secretion by human umbilical vein endothelial cells, support the hypothesis that neutrophils and neutrophil-derived products (H2O2) influence granuloma formation through induction of local MCP-1 expression. Hydrogen Peroxide 98-102 C-C motif chemokine ligand 2 Homo sapiens 373-378 9042155-10 1997 These in vivo data, coupled with in vitro data that indicate that both catalase-sensitive reagent H2O2 and neutrophil-derived reactive oxygen intermediates (ie, H2O2) can induce MCP-1 secretion by human umbilical vein endothelial cells, support the hypothesis that neutrophils and neutrophil-derived products (H2O2) influence granuloma formation through induction of local MCP-1 expression. reactive oxygen 126-141 C-C motif chemokine ligand 2 Homo sapiens 178-183 9042155-10 1997 These in vivo data, coupled with in vitro data that indicate that both catalase-sensitive reagent H2O2 and neutrophil-derived reactive oxygen intermediates (ie, H2O2) can induce MCP-1 secretion by human umbilical vein endothelial cells, support the hypothesis that neutrophils and neutrophil-derived products (H2O2) influence granuloma formation through induction of local MCP-1 expression. reactive oxygen 126-141 C-C motif chemokine ligand 2 Homo sapiens 373-378 9042155-10 1997 These in vivo data, coupled with in vitro data that indicate that both catalase-sensitive reagent H2O2 and neutrophil-derived reactive oxygen intermediates (ie, H2O2) can induce MCP-1 secretion by human umbilical vein endothelial cells, support the hypothesis that neutrophils and neutrophil-derived products (H2O2) influence granuloma formation through induction of local MCP-1 expression. Hydrogen Peroxide 161-165 C-C motif chemokine ligand 2 Homo sapiens 178-183 9042155-10 1997 These in vivo data, coupled with in vitro data that indicate that both catalase-sensitive reagent H2O2 and neutrophil-derived reactive oxygen intermediates (ie, H2O2) can induce MCP-1 secretion by human umbilical vein endothelial cells, support the hypothesis that neutrophils and neutrophil-derived products (H2O2) influence granuloma formation through induction of local MCP-1 expression. Hydrogen Peroxide 161-165 C-C motif chemokine ligand 2 Homo sapiens 373-378 9042155-10 1997 These in vivo data, coupled with in vitro data that indicate that both catalase-sensitive reagent H2O2 and neutrophil-derived reactive oxygen intermediates (ie, H2O2) can induce MCP-1 secretion by human umbilical vein endothelial cells, support the hypothesis that neutrophils and neutrophil-derived products (H2O2) influence granuloma formation through induction of local MCP-1 expression. Hydrogen Peroxide 161-165 C-C motif chemokine ligand 2 Homo sapiens 178-183 9042155-10 1997 These in vivo data, coupled with in vitro data that indicate that both catalase-sensitive reagent H2O2 and neutrophil-derived reactive oxygen intermediates (ie, H2O2) can induce MCP-1 secretion by human umbilical vein endothelial cells, support the hypothesis that neutrophils and neutrophil-derived products (H2O2) influence granuloma formation through induction of local MCP-1 expression. Hydrogen Peroxide 161-165 C-C motif chemokine ligand 2 Homo sapiens 373-378 9009224-3 1997 In addition, all three MCPs showed dose-dependent inhibition of adenylyl cyclase activity stimulated by forskolin (IC50 values: 0.3 nM for MCP-1, 7 nM for MCP-2, and 1.5 nM for MCP-3). Colforsin 104-113 C-C motif chemokine ligand 2 Homo sapiens 139-144 8989326-7 1997 Comparison of the three MCP-1 structures revealed a direct correlation between the main-chain conformation of the first two cysteine residues and the quaternary arrangements. Cysteine 124-132 C-C motif chemokine ligand 2 Homo sapiens 24-29 8943229-5 1996 Phosphopeptide and phosphoamino acid analysis of Stat5a and Stat5b immunoprecipitated from phosphate-labeled HC11 cells revealed that both proteins were constitutively phosphorylated on serine. Phosphates 91-100 C-C motif chemokine ligand 2 Homo sapiens 109-113 9489430-0 1997 [The effect of heparin on release of histamine from basophils under the influence of MCAF/MCP-I in patients with bronchial asthma]. Histamine 37-46 C-C motif chemokine ligand 2 Homo sapiens 85-89 9489430-11 1997 We observed that incubation of basophils with heparin inhibits histamine release as shown in the table: [table: see text] Preincubation of anti-IgE or MCAF/MCP-I with heparin did not induce any changes in histamine release. Heparin 46-53 C-C motif chemokine ligand 2 Homo sapiens 151-155 9489430-11 1997 We observed that incubation of basophils with heparin inhibits histamine release as shown in the table: [table: see text] Preincubation of anti-IgE or MCAF/MCP-I with heparin did not induce any changes in histamine release. Histamine 63-72 C-C motif chemokine ligand 2 Homo sapiens 151-155 9489430-11 1997 We observed that incubation of basophils with heparin inhibits histamine release as shown in the table: [table: see text] Preincubation of anti-IgE or MCAF/MCP-I with heparin did not induce any changes in histamine release. Heparin 167-174 C-C motif chemokine ligand 2 Homo sapiens 151-155 8955213-8 1996 These studies demonstrate that phosphorylation of Ser and Thr residues in the carboxyl-tail of CCR2B mediates receptor desensitization and internalization and may serve to limit the chemotactic response of leukocytes to MCP-1 and related chemokines. Serine 50-53 C-C motif chemokine ligand 2 Homo sapiens 220-225 8955213-8 1996 These studies demonstrate that phosphorylation of Ser and Thr residues in the carboxyl-tail of CCR2B mediates receptor desensitization and internalization and may serve to limit the chemotactic response of leukocytes to MCP-1 and related chemokines. Threonine 58-61 C-C motif chemokine ligand 2 Homo sapiens 220-225 8906847-0 1996 Stimulating properties of 5-oxo-eicosanoids for human monocytes: synergism with monocyte chemotactic protein-1 and -3. 5-oxo-eicosanoids 26-43 C-C motif chemokine ligand 2 Homo sapiens 80-117 11667575-3 1996 The reactions of 1-octene or 1-hexene and 1-methylcyclohexene with atomic hydrogen carried out in the presence of several transfer agents (CCl(4), CCl(3)Br, CCl(2)Br(2)) initiate a radical chain addition of CCl(2)X(*) and yield cyclized materials resulting from the S(H)i displacement of halogen by a carbon-centered radical. 1-octene 17-25 C-C motif chemokine ligand 2 Homo sapiens 157-165 8906847-6 1996 5-Oxo-ETEs increased in a synergistic fashion the monocyte migration to MCP-1 and MCP-3. 5-oxo-6,8,11,14-eicosatetraenoic acid 0-10 C-C motif chemokine ligand 2 Homo sapiens 72-77 8906847-7 1996 In the same range of concentrations, 5-oxo-ETE increased MCP-1-induced release of arachidonic acid from labeled monocytes. 5-Oxo-ETE 37-46 C-C motif chemokine ligand 2 Homo sapiens 57-62 8906847-7 1996 In the same range of concentrations, 5-oxo-ETE increased MCP-1-induced release of arachidonic acid from labeled monocytes. Arachidonic Acid 82-98 C-C motif chemokine ligand 2 Homo sapiens 57-62 8939160-8 1996 RESULTS: Replacing IgE- on basophils with IgE+ serum decreased the correlation between monocyte chemotactic protein-1 and histamine release (rho = 0.80, n = 280 vs p = 0.12, n = 18; p for difference between p values; < 0.05). Histamine 122-131 C-C motif chemokine ligand 2 Homo sapiens 87-117 11667575-3 1996 The reactions of 1-octene or 1-hexene and 1-methylcyclohexene with atomic hydrogen carried out in the presence of several transfer agents (CCl(4), CCl(3)Br, CCl(2)Br(2)) initiate a radical chain addition of CCl(2)X(*) and yield cyclized materials resulting from the S(H)i displacement of halogen by a carbon-centered radical. 1-hexene 29-37 C-C motif chemokine ligand 2 Homo sapiens 157-165 11667575-3 1996 The reactions of 1-octene or 1-hexene and 1-methylcyclohexene with atomic hydrogen carried out in the presence of several transfer agents (CCl(4), CCl(3)Br, CCl(2)Br(2)) initiate a radical chain addition of CCl(2)X(*) and yield cyclized materials resulting from the S(H)i displacement of halogen by a carbon-centered radical. 1-Methyl-1-cyclohexene 42-61 C-C motif chemokine ligand 2 Homo sapiens 157-165 8891198-8 1996 These experiments strongly support the hypothesis that MIP-1 alpha and MCP-1 contribute to the recruitment of leukocytes during the pulmonary inflammatory response to bleomycin challenge. Bleomycin 167-176 C-C motif chemokine ligand 2 Homo sapiens 71-76 8753839-6 1996 KT5926, an inhibitor of myosin light chain kinase, also inhibited histamine release in response to MCP-1 with an IC50 of 10(-6) M. Staurosporine, a potent inhibitor of protein kinase C, although being not specific, augmented MCP-1-induced histamine release by 31.9% at 10(-6) M. These results indicate the possible involvement of a series of kinases, including PI-3 kinase, in the signal transduction pathway used by MCP-1. Staurosporine 131-144 C-C motif chemokine ligand 2 Homo sapiens 99-104 8753839-6 1996 KT5926, an inhibitor of myosin light chain kinase, also inhibited histamine release in response to MCP-1 with an IC50 of 10(-6) M. Staurosporine, a potent inhibitor of protein kinase C, although being not specific, augmented MCP-1-induced histamine release by 31.9% at 10(-6) M. These results indicate the possible involvement of a series of kinases, including PI-3 kinase, in the signal transduction pathway used by MCP-1. Histamine 239-248 C-C motif chemokine ligand 2 Homo sapiens 99-104 8830798-4 1996 Enzyme-linked immunoassay GHSA (500 micrograms/mL)-treated hRPE cells secreted levels of IL-8 and MCP-1 detectable within 4 h and reached 26.0 +/- 1.3 and 42.2 0.4 ng/10(6) cells/mL after 24 h, respectively. ghsa 26-30 C-C motif chemokine ligand 2 Homo sapiens 98-103 8830798-5 1996 Induction of IL-8 and MCP-1 by GHSA at concentrations ranging from 62.5 to 3,000 micrograms/mL exhibited dose-dependent kinetics. ghsa 31-35 C-C motif chemokine ligand 2 Homo sapiens 22-27 8830798-6 1996 The GHSA-induced chemokine secretion by hRPE was almost completely inhibited by actinomycin D and cycloheximide, suggesting that de novo mRNA and protein synthesis are necessary for the GHSA-induced IL-8 and MCP-1 production. ghsa 4-8 C-C motif chemokine ligand 2 Homo sapiens 208-213 8830798-6 1996 The GHSA-induced chemokine secretion by hRPE was almost completely inhibited by actinomycin D and cycloheximide, suggesting that de novo mRNA and protein synthesis are necessary for the GHSA-induced IL-8 and MCP-1 production. Dactinomycin 80-93 C-C motif chemokine ligand 2 Homo sapiens 208-213 8830798-6 1996 The GHSA-induced chemokine secretion by hRPE was almost completely inhibited by actinomycin D and cycloheximide, suggesting that de novo mRNA and protein synthesis are necessary for the GHSA-induced IL-8 and MCP-1 production. Cycloheximide 98-111 C-C motif chemokine ligand 2 Homo sapiens 208-213 8830798-6 1996 The GHSA-induced chemokine secretion by hRPE was almost completely inhibited by actinomycin D and cycloheximide, suggesting that de novo mRNA and protein synthesis are necessary for the GHSA-induced IL-8 and MCP-1 production. ghsa 186-190 C-C motif chemokine ligand 2 Homo sapiens 208-213 8830798-7 1996 Northern blot analysis of GHSA-induced hRPE IL-8 and MCP-1 mRNA expression corresponded to the time- and dose-dependent increases measured by enzyme-linked immunosorbent assay. ghsa 26-30 C-C motif chemokine ligand 2 Homo sapiens 53-58 8830798-8 1996 High concentrations of glucose (20 mM; 360 mg/dl) increased GHSA-induced hRPE IL-8 and MCP-1 secretion, whereas added insulin (0.5 ng/mL) inhibited IL-8 but not MCP-1 protein secretion and mRNA expression. Glucose 23-30 C-C motif chemokine ligand 2 Homo sapiens 87-92 8830798-8 1996 High concentrations of glucose (20 mM; 360 mg/dl) increased GHSA-induced hRPE IL-8 and MCP-1 secretion, whereas added insulin (0.5 ng/mL) inhibited IL-8 but not MCP-1 protein secretion and mRNA expression. ghsa 60-64 C-C motif chemokine ligand 2 Homo sapiens 87-92 9275656-4 1996 MCP-1 mRNA expression in monocytes was examined by slot blot and Northern blot analysis using a gamma 32P-end-labelled 35 mer oligonucleotide probe of MCP-1. Oligonucleotides 126-141 C-C motif chemokine ligand 2 Homo sapiens 0-5 8980877-2 1996 For most of the chemokines (IL-8, GRO-alpha, MCP-1, MIP-1 alpha) the difference in the response of leukocytes in EDTA anticoagulated blood vs those in heparinized blood was the degree of their maximal response, with a slightly higher maximal increase in CD11b expression usually seen in cells from EDTA anticoagulated blood. Edetic Acid 113-117 C-C motif chemokine ligand 2 Homo sapiens 45-50 8753839-0 1996 Pharmacologic study of basophil histamine release induced by monocyte chemotactic protein-1 with kinase inhibitors. Histamine 32-41 C-C motif chemokine ligand 2 Homo sapiens 61-91 8753839-2 1996 In this study, we examined the effect of a panel of kinase inhibitors on MCP-1-induced histamine release from human basophils to characterize the signaling pathway used by this chemokine. Histamine 87-96 C-C motif chemokine ligand 2 Homo sapiens 73-78 8753839-3 1996 Genistein (3 micrograms/ml), an inhibitor of tyrosine kinase, inhibited MCP-1-induced histamine release by 44%. Genistein 0-9 C-C motif chemokine ligand 2 Homo sapiens 72-77 8753839-3 1996 Genistein (3 micrograms/ml), an inhibitor of tyrosine kinase, inhibited MCP-1-induced histamine release by 44%. Histamine 86-95 C-C motif chemokine ligand 2 Homo sapiens 72-77 8753839-5 1996 It blocked MCP-1-induced histamine release with an IC50 of 3.3 x 10(-8) M indicating a role of PI-3 kinase in this reaction. Histamine 25-34 C-C motif chemokine ligand 2 Homo sapiens 11-16 8753839-6 1996 KT5926, an inhibitor of myosin light chain kinase, also inhibited histamine release in response to MCP-1 with an IC50 of 10(-6) M. Staurosporine, a potent inhibitor of protein kinase C, although being not specific, augmented MCP-1-induced histamine release by 31.9% at 10(-6) M. These results indicate the possible involvement of a series of kinases, including PI-3 kinase, in the signal transduction pathway used by MCP-1. KT 5926 0-6 C-C motif chemokine ligand 2 Homo sapiens 99-104 8753839-6 1996 KT5926, an inhibitor of myosin light chain kinase, also inhibited histamine release in response to MCP-1 with an IC50 of 10(-6) M. Staurosporine, a potent inhibitor of protein kinase C, although being not specific, augmented MCP-1-induced histamine release by 31.9% at 10(-6) M. These results indicate the possible involvement of a series of kinases, including PI-3 kinase, in the signal transduction pathway used by MCP-1. KT 5926 0-6 C-C motif chemokine ligand 2 Homo sapiens 225-230 8753839-6 1996 KT5926, an inhibitor of myosin light chain kinase, also inhibited histamine release in response to MCP-1 with an IC50 of 10(-6) M. Staurosporine, a potent inhibitor of protein kinase C, although being not specific, augmented MCP-1-induced histamine release by 31.9% at 10(-6) M. These results indicate the possible involvement of a series of kinases, including PI-3 kinase, in the signal transduction pathway used by MCP-1. KT 5926 0-6 C-C motif chemokine ligand 2 Homo sapiens 225-230 8753839-6 1996 KT5926, an inhibitor of myosin light chain kinase, also inhibited histamine release in response to MCP-1 with an IC50 of 10(-6) M. Staurosporine, a potent inhibitor of protein kinase C, although being not specific, augmented MCP-1-induced histamine release by 31.9% at 10(-6) M. These results indicate the possible involvement of a series of kinases, including PI-3 kinase, in the signal transduction pathway used by MCP-1. Histamine 66-75 C-C motif chemokine ligand 2 Homo sapiens 99-104 8877158-8 1996 About 90-95% of the total histamine containing capability was attributable to MCP-1/MCAF. Histamine 26-35 C-C motif chemokine ligand 2 Homo sapiens 78-83 8877158-8 1996 About 90-95% of the total histamine containing capability was attributable to MCP-1/MCAF. Histamine 26-35 C-C motif chemokine ligand 2 Homo sapiens 84-88 8711735-6 1996 Diisocyanate-exposed workers were tested for diisocyanate antigen-stimulated enhancement of HRF, MCP-1, and RANTES production in supernatants of PBMCs and for serum specific IgE and IgG antibody levels to diisocyanate antigens bound to human serum albumin (HSA). 4,4'-diphenylmethane diisocyanate 0-12 C-C motif chemokine ligand 2 Homo sapiens 97-102 8711735-7 1996 PBMCs of workers with diisocyanate OA showed significantly increased production of antigen-specific HRF activity and MCP-1 ( > 300 ng/ml) compared to diisocyanate-exposed asymptomatic workers (P < 0.05). 4,4'-diphenylmethane diisocyanate 22-34 C-C motif chemokine ligand 2 Homo sapiens 117-122 8711735-13 1996 The results suggest that diisocyanate antigen enhancement of HRF and MCP-1 production are stimulated by hapten-specific T cell reactions. 4,4'-diphenylmethane diisocyanate 25-37 C-C motif chemokine ligand 2 Homo sapiens 69-74 8967390-7 1996 ECs pretreated with stretch-activated ion channel blocker gadolinium or with ryanodine to deplete intracellular stored Ca2+ strongly inhibited the strain-induced MCP-1 levels. Gadolinium 58-68 C-C motif chemokine ligand 2 Homo sapiens 162-167 8671975-11 1996 In the normal control group, urinary MCP-1 levels ranged between 38 ng/mmol Cr and 74 ng/mmol Cr with a median of 50 ng/mmol Cr. Chromium 76-78 C-C motif chemokine ligand 2 Homo sapiens 37-42 8671975-11 1996 In the normal control group, urinary MCP-1 levels ranged between 38 ng/mmol Cr and 74 ng/mmol Cr with a median of 50 ng/mmol Cr. Chromium 94-96 C-C motif chemokine ligand 2 Homo sapiens 37-42 8671975-11 1996 In the normal control group, urinary MCP-1 levels ranged between 38 ng/mmol Cr and 74 ng/mmol Cr with a median of 50 ng/mmol Cr. Chromium 94-96 C-C motif chemokine ligand 2 Homo sapiens 37-42 8671975-12 1996 The fractional excretion of MCP-1, calculated on the basis of MCP-1 and creatinine clearances, was found also to be significantly higher in the Rj group as compared to the NRj group. Creatinine 72-82 C-C motif chemokine ligand 2 Homo sapiens 28-33 8639784-7 1996 (2) Anti-G(i) inhibited GTP binding and GTPase activity in the presence of MCP-1 or RANTES but not in the presence of MIP-1 alpha. Guanosine Triphosphate 24-27 C-C motif chemokine ligand 2 Homo sapiens 75-80 8841838-2 1996 We now report that pentamidine inhibited the human whole blood production of the chemotactic cytokines (chemokines) interleukin (IL)-8, growth related gene alpha (GRO alpha) and monocyte chemotactic protein-1 (MCP-1). Pentamidine 19-30 C-C motif chemokine ligand 2 Homo sapiens 178-208 8841838-2 1996 We now report that pentamidine inhibited the human whole blood production of the chemotactic cytokines (chemokines) interleukin (IL)-8, growth related gene alpha (GRO alpha) and monocyte chemotactic protein-1 (MCP-1). Pentamidine 19-30 C-C motif chemokine ligand 2 Homo sapiens 210-215 8671975-9 1996 RESULTS: Urinary excretion of MCP-1 in the Rj group ranged between 250 ng/mmol Cr and 3148 ng/mmol Cr with a median of 612 ng/mmol Cr. Chromium 79-81 C-C motif chemokine ligand 2 Homo sapiens 30-35 8671975-9 1996 RESULTS: Urinary excretion of MCP-1 in the Rj group ranged between 250 ng/mmol Cr and 3148 ng/mmol Cr with a median of 612 ng/mmol Cr. Chromium 99-101 C-C motif chemokine ligand 2 Homo sapiens 30-35 8671975-9 1996 RESULTS: Urinary excretion of MCP-1 in the Rj group ranged between 250 ng/mmol Cr and 3148 ng/mmol Cr with a median of 612 ng/mmol Cr. Chromium 99-101 C-C motif chemokine ligand 2 Homo sapiens 30-35 8622597-1 1996 Lysophosphatidylcholine (LPC increased monocyte chemoattractant protein-1 (MCP-1) messenger RNA concentrations in human umbilical vein endothelial cells (HUVECs). Lysophosphatidylcholines 0-23 C-C motif chemokine ligand 2 Homo sapiens 39-73 8622597-1 1996 Lysophosphatidylcholine (LPC increased monocyte chemoattractant protein-1 (MCP-1) messenger RNA concentrations in human umbilical vein endothelial cells (HUVECs). Lysophosphatidylcholines 0-23 C-C motif chemokine ligand 2 Homo sapiens 75-80 8622597-4 1996 The amount of MCP-1 released from HUVECs measured using an enzyme-linked immunosorbent assay (ELISA) showed a 38% increase in the presence of 50 micromol/L LPC, but not in the presence of phosphatidylcholine or lysophosphatidylethanolamine. lysophosphatidylethanolamine 211-239 C-C motif chemokine ligand 2 Homo sapiens 14-19 8622597-5 1996 Coincubation with staurosporine, a potent inhibitor of protein kinase C (PKC) activity, attenuated the LPC-induced increase in MCP-1 mRNA levels by 53%. Staurosporine 18-31 C-C motif chemokine ligand 2 Homo sapiens 127-132 8967390-7 1996 ECs pretreated with stretch-activated ion channel blocker gadolinium or with ryanodine to deplete intracellular stored Ca2+ strongly inhibited the strain-induced MCP-1 levels. Ryanodine 77-86 C-C motif chemokine ligand 2 Homo sapiens 162-167 8648917-7 1996 Moreover, elevated urinary MCAF levels were dramatically decreased during steroid therapy-induced convalescence in 29 patients examined serially (13.9 +/- 4.5 vs. 5.3 +/- 1.7 pg/ml . Steroids 74-81 C-C motif chemokine ligand 2 Homo sapiens 27-31 8626384-1 1996 Monocyte chemotactic protein (MCP)-1, a member of the C-C (or beta) branch of the chemokine superfamily, at chemotactic concentrations, induced a rapid release of [3H]arachidonic acid but not of [14C]oleic acid from prelabeled human monocytes. 3h]arachidonic acid 164-183 C-C motif chemokine ligand 2 Homo sapiens 0-36 8626384-1 1996 Monocyte chemotactic protein (MCP)-1, a member of the C-C (or beta) branch of the chemokine superfamily, at chemotactic concentrations, induced a rapid release of [3H]arachidonic acid but not of [14C]oleic acid from prelabeled human monocytes. Carbon-14 196-200 C-C motif chemokine ligand 2 Homo sapiens 0-36 24203298-1 1996 The single-electron capture (SEC) by dichlorocarbene dications with eight different atomic and molecular target gases, CCl 2 (2+) + G CCl 2 (+) + G(+), has been studied by product ion spectroscopy and ion kinetic energy spectroscopy. dichlorocarbene 37-52 C-C motif chemokine ligand 2 Homo sapiens 119-124 24203298-1 1996 The single-electron capture (SEC) by dichlorocarbene dications with eight different atomic and molecular target gases, CCl 2 (2+) + G CCl 2 (+) + G(+), has been studied by product ion spectroscopy and ion kinetic energy spectroscopy. dichlorocarbene 37-52 C-C motif chemokine ligand 2 Homo sapiens 136-141 8832978-8 1996 Prior addition of antioxidant, N-acetyl-L-cysteine (NAC) or 2-oxothiazolidine-4-carboxylate (OTC), suppressed TNF-alpha stimulated expressions of IL-8, MCP-1, and collagenase mRNA in a dose dependent manner. 2-oxothiazolidine-4-carboxylic acid 60-91 C-C motif chemokine ligand 2 Homo sapiens 152-157 8832978-12 1996 CONCLUSION: Our data suggest that TNF-alpha induces expression of proinflammatory cytokines such as IL-8 and MCP-1 through generation of reactive oxygen intermediates and subsequent activation of NF-kappa B in human synovial cells, and the antioxidants may inhibit, at least in part, the activation of NF-kappa B by TNF-alpha. reactive oxygen intermediates 137-166 C-C motif chemokine ligand 2 Homo sapiens 109-114 8728019-3 1996 The synthetic glucocorticoid dexamethasone 1) inhibits the LPS-initiated vascular leak of plasma proteins into the airspace, 2) inhibits the LPS-initiated emigration of neutrophils and lymphocytes into the airspace in a dose-dependent fashion, and 3) inhibits LPS-initiated mRNA and/or bronchoalveolar lavage protein expression of cytokines (TNF, IL-1 and IL-6) and chemokines (MIP-1 alpha, MIP-2 and MCP-1). Dexamethasone 29-42 C-C motif chemokine ligand 2 Homo sapiens 401-406 8626384-4 1996 Monocytes cultured in the presence of 10 microM antisense oligonucleotide for 48 h showed a marked decrease (57 +/- 5%; n = 4) of cPLA2 expression, as evaluated by Western blot analysis and a nearly complete inhibition (81.8 +/- 4.2%; n = 3) of [3H]arachidonic acid release in MCP-1-stimulated cells. Oligonucleotides 58-73 C-C motif chemokine ligand 2 Homo sapiens 277-282 8626384-9 1996 These data show that cPLA2 plays a major role in [3H]arachidonic acid release by MCP-1 in human monocytes and provide direct evidence for the involvement of cPLA2 in C-C chemokine-induced monocyte chemotaxis. Tritium 50-52 C-C motif chemokine ligand 2 Homo sapiens 81-86 8626384-9 1996 These data show that cPLA2 plays a major role in [3H]arachidonic acid release by MCP-1 in human monocytes and provide direct evidence for the involvement of cPLA2 in C-C chemokine-induced monocyte chemotaxis. Arachidonic Acid 53-69 C-C motif chemokine ligand 2 Homo sapiens 81-86 8627035-7 1996 The results show that self-healing LCL is associated with higher levels of MCP-1, which may stimulate macrophage microbicidal mechanisms, and nonhealing DCL is associated with higher levels of MIP-alpha. dextramycine 35-38 C-C motif chemokine ligand 2 Homo sapiens 75-80 8781708-0 1996 Physiological concentration of 17 beta-estradiol inhibits chemotaxis of human monocytes in response to monocyte chemotactic protein 1. Estradiol 31-48 C-C motif chemokine ligand 2 Homo sapiens 103-133 8769945-8 1996 We also showed that dexamethasone and interferon-alpha downregulate MCP-1 mRNA in cultured human vascular smooth muscle cells. Dexamethasone 20-33 C-C motif chemokine ligand 2 Homo sapiens 68-73 8641338-1 1996 Both monocyte chemotactic and activating factor (MCAF) and N-formyl-methionyl-leucyl-phenylalanine (FMLP) stimulated an increase in cytoplasmic free Ca2+ ([Ca2+]i) and changes in intracellular pH (pHi) in human monocytes in parallel at lower concentrations and stimulated superoxide (O2-) release and changes in transmembrane potential in parallel at higher concentrations. Superoxides 272-282 C-C motif chemokine ligand 2 Homo sapiens 5-47 8641338-1 1996 Both monocyte chemotactic and activating factor (MCAF) and N-formyl-methionyl-leucyl-phenylalanine (FMLP) stimulated an increase in cytoplasmic free Ca2+ ([Ca2+]i) and changes in intracellular pH (pHi) in human monocytes in parallel at lower concentrations and stimulated superoxide (O2-) release and changes in transmembrane potential in parallel at higher concentrations. Superoxides 284-286 C-C motif chemokine ligand 2 Homo sapiens 5-47 8573103-7 1996 Point mutations of Thr-10 to Arg and Tyr-13 to Ile greatly lowered MCP-1 activity. Isoleucine 47-50 C-C motif chemokine ligand 2 Homo sapiens 67-72 8573103-9 1996 Insertion of a Pro between these two residues, or their substitution by the sequence Gly-Pro-His, caused nearly complete loss of MCP-1 activity. Proline 15-18 C-C motif chemokine ligand 2 Homo sapiens 129-134 8573103-9 1996 Insertion of a Pro between these two residues, or their substitution by the sequence Gly-Pro-His, caused nearly complete loss of MCP-1 activity. Gly-Pro-His 85-96 C-C motif chemokine ligand 2 Homo sapiens 129-134 8781708-4 1996 We investigated the effect of 17 beta-estradiol on the migration of human monocytes in response to MCP-1, using a modified Boyden chamber. Estradiol 30-47 C-C motif chemokine ligand 2 Homo sapiens 99-104 8781708-5 1996 A physiological concentration of 17 beta-estradiol (10(12) - 10(4)M) inhibited the migration of monocytes exposed to MCP-1. Estradiol 33-50 C-C motif chemokine ligand 2 Homo sapiens 117-122 8781708-6 1996 Two estrogen receptor antagonists, tamoxifen and clomiphene, each restored monocyte chemotaxis to MCP-1 to control level, even in the presence of 17 beta-estradiol, suggesting that estrogen receptors are related to the effect of 17 beta-estradiol. Tamoxifen 35-44 C-C motif chemokine ligand 2 Homo sapiens 98-103 8781708-6 1996 Two estrogen receptor antagonists, tamoxifen and clomiphene, each restored monocyte chemotaxis to MCP-1 to control level, even in the presence of 17 beta-estradiol, suggesting that estrogen receptors are related to the effect of 17 beta-estradiol. Clomiphene 49-59 C-C motif chemokine ligand 2 Homo sapiens 98-103 8781708-6 1996 Two estrogen receptor antagonists, tamoxifen and clomiphene, each restored monocyte chemotaxis to MCP-1 to control level, even in the presence of 17 beta-estradiol, suggesting that estrogen receptors are related to the effect of 17 beta-estradiol. Estradiol 229-246 C-C motif chemokine ligand 2 Homo sapiens 98-103 8781708-8 1996 These findings suggest that inhibition of the chemotactic response of monocytes exposed to MCP-1 may be one mechanism for the anti-atherogenic effect of 17 beta-estradiol. Estradiol 153-170 C-C motif chemokine ligand 2 Homo sapiens 91-96 8568122-2 1996 IL-8 inhibits MCAF-induced histamine release from basophils. Histamine 27-36 C-C motif chemokine ligand 2 Homo sapiens 14-18 8568122-10 1996 We also found a correlation between the level of MCAF/MCP-1 and IL-8 and the level of histamine or IL-8 and ECP. Histamine 86-95 C-C motif chemokine ligand 2 Homo sapiens 49-53 8568122-10 1996 We also found a correlation between the level of MCAF/MCP-1 and IL-8 and the level of histamine or IL-8 and ECP. Histamine 86-95 C-C motif chemokine ligand 2 Homo sapiens 54-59 8587246-7 1995 Furthermore, PMA induced an increase in MCP-1 mRNA levels, whereas dibutyryl cyclic AMP and forskolin had minimal effects. Tetradecanoylphorbol Acetate 13-16 C-C motif chemokine ligand 2 Homo sapiens 40-45 8557776-7 1996 Since some ATP- or UTP-induced genes code for chemotactic proteins (monocyte chemoattractant protein-1 and osteopontin), this study suggests that these nucleotides may contribute to vascular or blood cell migration and proliferation and consequently to the genesis of arterial diseases. Adenosine Triphosphate 11-14 C-C motif chemokine ligand 2 Homo sapiens 68-102 8557776-7 1996 Since some ATP- or UTP-induced genes code for chemotactic proteins (monocyte chemoattractant protein-1 and osteopontin), this study suggests that these nucleotides may contribute to vascular or blood cell migration and proliferation and consequently to the genesis of arterial diseases. Uridine Triphosphate 19-22 C-C motif chemokine ligand 2 Homo sapiens 68-102 8558841-10 1995 methylprednisolone significantly lowered urinary MCP-1 in patients with active lupus nephritis. Methylprednisolone 0-18 C-C motif chemokine ligand 2 Homo sapiens 49-54 9225244-1 1996 The affinity-based N (alpha)-amino protecting group tetrabenzo[a,c,g,i]fluorenyl-17 methoxycarbonyl (Tbfmoc) has been utilized as a hydrophobic probe to allow the simple, quick and highly effective isolation of a 76 residue cysteine-containing protein (MCP-1). n (alpha) 19-28 C-C motif chemokine ligand 2 Homo sapiens 253-258 9225244-1 1996 The affinity-based N (alpha)-amino protecting group tetrabenzo[a,c,g,i]fluorenyl-17 methoxycarbonyl (Tbfmoc) has been utilized as a hydrophobic probe to allow the simple, quick and highly effective isolation of a 76 residue cysteine-containing protein (MCP-1). amino 29-34 C-C motif chemokine ligand 2 Homo sapiens 253-258 9225244-1 1996 The affinity-based N (alpha)-amino protecting group tetrabenzo[a,c,g,i]fluorenyl-17 methoxycarbonyl (Tbfmoc) has been utilized as a hydrophobic probe to allow the simple, quick and highly effective isolation of a 76 residue cysteine-containing protein (MCP-1). tetrabenzo[a,c,g,i]fluorenyl-17 methoxycarbonyl 52-99 C-C motif chemokine ligand 2 Homo sapiens 253-258 9225244-1 1996 The affinity-based N (alpha)-amino protecting group tetrabenzo[a,c,g,i]fluorenyl-17 methoxycarbonyl (Tbfmoc) has been utilized as a hydrophobic probe to allow the simple, quick and highly effective isolation of a 76 residue cysteine-containing protein (MCP-1). tbfmoc 101-107 C-C motif chemokine ligand 2 Homo sapiens 253-258 9225244-1 1996 The affinity-based N (alpha)-amino protecting group tetrabenzo[a,c,g,i]fluorenyl-17 methoxycarbonyl (Tbfmoc) has been utilized as a hydrophobic probe to allow the simple, quick and highly effective isolation of a 76 residue cysteine-containing protein (MCP-1). Cysteine 224-232 C-C motif chemokine ligand 2 Homo sapiens 253-258 8676808-5 1996 In vitro, lovastatin has been shown to downregulate mesangial cell production of monocyte chemoattractant protein-1 and colony-stimulating factor. Lovastatin 10-20 C-C motif chemokine ligand 2 Homo sapiens 81-115 8856246-8 1996 Superoxide also induced mRNA expression for MCP-1 on MC. Superoxides 0-10 C-C motif chemokine ligand 2 Homo sapiens 44-49 8856246-10 1996 Since morphine activates MC to produce superoxide and DMTU attenuated the effect of superoxide on MC, the effect of morphine on the migration of macrophages may be mediated through superoxide-induced generation of MCP-1. 1,3-dimethylthiourea 54-58 C-C motif chemokine ligand 2 Homo sapiens 214-219 8856246-10 1996 Since morphine activates MC to produce superoxide and DMTU attenuated the effect of superoxide on MC, the effect of morphine on the migration of macrophages may be mediated through superoxide-induced generation of MCP-1. Superoxides 84-94 C-C motif chemokine ligand 2 Homo sapiens 214-219 8856246-10 1996 Since morphine activates MC to produce superoxide and DMTU attenuated the effect of superoxide on MC, the effect of morphine on the migration of macrophages may be mediated through superoxide-induced generation of MCP-1. Morphine 116-124 C-C motif chemokine ligand 2 Homo sapiens 214-219 8856246-10 1996 Since morphine activates MC to produce superoxide and DMTU attenuated the effect of superoxide on MC, the effect of morphine on the migration of macrophages may be mediated through superoxide-induced generation of MCP-1. Superoxides 84-94 C-C motif chemokine ligand 2 Homo sapiens 214-219 8587246-8 1995 Inhibition study using protein kinase inhibitors revealed that MCP-1 mRNA expression induced by IL-1 beta and TNF-alpha was suppressed by the tyrosine kinase inhibitor genistein, not by the protein kinase C inhibitors staurosporine or H-7, or the protein kinase A inhibitor H-89, suggesting an important role of tyrosine kinase in the cytokine-induced MCP-1 gene expression. Genistein 168-177 C-C motif chemokine ligand 2 Homo sapiens 63-68 8587246-8 1995 Inhibition study using protein kinase inhibitors revealed that MCP-1 mRNA expression induced by IL-1 beta and TNF-alpha was suppressed by the tyrosine kinase inhibitor genistein, not by the protein kinase C inhibitors staurosporine or H-7, or the protein kinase A inhibitor H-89, suggesting an important role of tyrosine kinase in the cytokine-induced MCP-1 gene expression. Genistein 168-177 C-C motif chemokine ligand 2 Homo sapiens 352-357 8587246-8 1995 Inhibition study using protein kinase inhibitors revealed that MCP-1 mRNA expression induced by IL-1 beta and TNF-alpha was suppressed by the tyrosine kinase inhibitor genistein, not by the protein kinase C inhibitors staurosporine or H-7, or the protein kinase A inhibitor H-89, suggesting an important role of tyrosine kinase in the cytokine-induced MCP-1 gene expression. N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide 274-278 C-C motif chemokine ligand 2 Homo sapiens 63-68 8587246-9 1995 Dexamethasone had a small inhibitory effect on constitutive MCP-1 mRNA expression, but no effect on the induction by TNF-alpha. Dexamethasone 0-13 C-C motif chemokine ligand 2 Homo sapiens 60-65 8564263-0 1995 The effect of a synthetic 7-thiaprostaglandin E1 derivative, TEI-6122, on monocyte chemoattractant protein-1 induced chemotaxis in THP-1 cells. 7-thiaprostaglandin e1 26-48 C-C motif chemokine ligand 2 Homo sapiens 74-108 8808219-7 1995 MCAF before HD session in long-term HD patients was the same whether HD was carried out with either cellulosic (CUP) or synthetic (PMMA) membrane dialysers. Polymethyl Methacrylate 131-135 C-C motif chemokine ligand 2 Homo sapiens 0-4 8808219-8 1995 Intradialytic increase in plasma MCAF during a single HD session was observed in both patient groups dialysed with CUP or PMMA membranes. Polymethyl Methacrylate 122-126 C-C motif chemokine ligand 2 Homo sapiens 33-37 8550082-11 1995 Our report describes additional biological activities for MCP-1, suggesting for the first time that this human monocyte chemoattractant plays a fundamental role in histamine and serotonin release and cell aggregation in rat peritoneal mast cells. Histamine 164-173 C-C motif chemokine ligand 2 Homo sapiens 58-63 8550082-11 1995 Our report describes additional biological activities for MCP-1, suggesting for the first time that this human monocyte chemoattractant plays a fundamental role in histamine and serotonin release and cell aggregation in rat peritoneal mast cells. Serotonin 178-187 C-C motif chemokine ligand 2 Homo sapiens 58-63 7592725-11 1995 In the chemotactic assay, phosphatidic acid and lysophosphatidic acid induced a complete homologous desensitization and only partially cross-desensitized one with each other, or with diacyl-glycerol and monocyte chemotactic protein-1. Phosphatidic Acids 26-43 C-C motif chemokine ligand 2 Homo sapiens 203-233 7592725-11 1995 In the chemotactic assay, phosphatidic acid and lysophosphatidic acid induced a complete homologous desensitization and only partially cross-desensitized one with each other, or with diacyl-glycerol and monocyte chemotactic protein-1. lysophosphatidic acid 48-69 C-C motif chemokine ligand 2 Homo sapiens 203-233 7592725-12 1995 Suramine inhibited monocyte chemotaxis with a different efficiency phosphatidic acid > lysophosphatidic acid" diacyl-glycerol On the contrary, monocyte chemotactic protein-1-induced chemotaxis was not affected by the drug. Suramin 0-8 C-C motif chemokine ligand 2 Homo sapiens 146-176 8599808-5 1995 Oxygen radicals act as second messenger for the activation of cytokines via NF-kappaB transcription factor, they stimulate the formation of TNF-alpha, IL-1, IL-6 and influence the expression of monocyte-specific cytokines (CSF-1 and MCP-1). Reactive Oxygen Species 0-15 C-C motif chemokine ligand 2 Homo sapiens 233-238 8544404-5 1995 Further analysis showed that various cell lines of human proximal tubular epithelial cells (PTEC) produce MCP-1 in culture under serum-free conditions and that the production is inhibited by cycloheximide. Cycloheximide 191-204 C-C motif chemokine ligand 2 Homo sapiens 106-111 8564263-0 1995 The effect of a synthetic 7-thiaprostaglandin E1 derivative, TEI-6122, on monocyte chemoattractant protein-1 induced chemotaxis in THP-1 cells. tei 61-64 C-C motif chemokine ligand 2 Homo sapiens 74-108 8564263-1 1995 1 The ability of various prostaglandins (PGs) to inhibit monocyte chemotaxis induced by monocyte chemoattractant protein-1 (MCP-1) was investigated with a human monocytic leukaemia cell line, THP-1. Prostaglandins 25-39 C-C motif chemokine ligand 2 Homo sapiens 88-122 8564263-1 1995 1 The ability of various prostaglandins (PGs) to inhibit monocyte chemotaxis induced by monocyte chemoattractant protein-1 (MCP-1) was investigated with a human monocytic leukaemia cell line, THP-1. Prostaglandins 25-39 C-C motif chemokine ligand 2 Homo sapiens 124-129 8564263-1 1995 1 The ability of various prostaglandins (PGs) to inhibit monocyte chemotaxis induced by monocyte chemoattractant protein-1 (MCP-1) was investigated with a human monocytic leukaemia cell line, THP-1. Prostaglandins 41-44 C-C motif chemokine ligand 2 Homo sapiens 88-122 8564263-1 1995 1 The ability of various prostaglandins (PGs) to inhibit monocyte chemotaxis induced by monocyte chemoattractant protein-1 (MCP-1) was investigated with a human monocytic leukaemia cell line, THP-1. Prostaglandins 41-44 C-C motif chemokine ligand 2 Homo sapiens 124-129 8564263-3 1995 2 TEI-6122, a synthetic 7-thia-PGE1 derivative, inhibited chemotaxis of THP-1 cells induced by MCP-1 with an IC50 of 1.5 pM. tei 2-5 C-C motif chemokine ligand 2 Homo sapiens 95-100 8564263-3 1995 2 TEI-6122, a synthetic 7-thia-PGE1 derivative, inhibited chemotaxis of THP-1 cells induced by MCP-1 with an IC50 of 1.5 pM. 7-thia 24-30 C-C motif chemokine ligand 2 Homo sapiens 95-100 8564263-3 1995 2 TEI-6122, a synthetic 7-thia-PGE1 derivative, inhibited chemotaxis of THP-1 cells induced by MCP-1 with an IC50 of 1.5 pM. Alprostadil 31-35 C-C motif chemokine ligand 2 Homo sapiens 95-100 8564263-10 1995 5 It is concluded that TEI-6122, a synthetic 7-thia-PGE1 derivative is a much more potent inhibitor of MCP-1-induced THP-1 cell chemotaxis than PGEI and PGE2 which are the best inhibitors among the natural PGs tested, while neither intracellular cyclic AMP accumulation nor effects on Ca2+ mobilization account for the extremely potent inhibitory activity of TEI-6122. tei 23-26 C-C motif chemokine ligand 2 Homo sapiens 103-108 8564263-10 1995 5 It is concluded that TEI-6122, a synthetic 7-thia-PGE1 derivative is a much more potent inhibitor of MCP-1-induced THP-1 cell chemotaxis than PGEI and PGE2 which are the best inhibitors among the natural PGs tested, while neither intracellular cyclic AMP accumulation nor effects on Ca2+ mobilization account for the extremely potent inhibitory activity of TEI-6122. 7-thia-pge1 45-56 C-C motif chemokine ligand 2 Homo sapiens 103-108 8564263-10 1995 5 It is concluded that TEI-6122, a synthetic 7-thia-PGE1 derivative is a much more potent inhibitor of MCP-1-induced THP-1 cell chemotaxis than PGEI and PGE2 which are the best inhibitors among the natural PGs tested, while neither intracellular cyclic AMP accumulation nor effects on Ca2+ mobilization account for the extremely potent inhibitory activity of TEI-6122. Prostaglandins 206-209 C-C motif chemokine ligand 2 Homo sapiens 103-108 8564263-10 1995 5 It is concluded that TEI-6122, a synthetic 7-thia-PGE1 derivative is a much more potent inhibitor of MCP-1-induced THP-1 cell chemotaxis than PGEI and PGE2 which are the best inhibitors among the natural PGs tested, while neither intracellular cyclic AMP accumulation nor effects on Ca2+ mobilization account for the extremely potent inhibitory activity of TEI-6122. Cyclic AMP 246-256 C-C motif chemokine ligand 2 Homo sapiens 103-108 8564263-10 1995 5 It is concluded that TEI-6122, a synthetic 7-thia-PGE1 derivative is a much more potent inhibitor of MCP-1-induced THP-1 cell chemotaxis than PGEI and PGE2 which are the best inhibitors among the natural PGs tested, while neither intracellular cyclic AMP accumulation nor effects on Ca2+ mobilization account for the extremely potent inhibitory activity of TEI-6122. tei 359-362 C-C motif chemokine ligand 2 Homo sapiens 103-108 7651403-8 1995 Finally, although 7ND inhibits wild-type MCP-1 activity, it has no effect on cross-linked MCP-1. 7ND 18-21 C-C motif chemokine ligand 2 Homo sapiens 41-46 7662986-9 1995 Thapsigargin, which empties intracellular Ca2+ stores, inhibited f-MLP-induced [Ca2+]i increase but fully blocked the action of MCP-1 only when combined with Ni2+. Thapsigargin 0-12 C-C motif chemokine ligand 2 Homo sapiens 128-133 8569088-8 1995 Conversely, raising intracellular cyclic-AMP levels, or exposing mesangial cells to herbimycin A, treatments that block IL-1-induced MCP-1 mRNA expression, significantly attenuated NF-kappa B activation. herbimycin 84-96 C-C motif chemokine ligand 2 Homo sapiens 133-138 8569088-9 1995 Finally, blocking the synthesis of one of the protein subunits of NF-kappa B with an antisense oligonucleotide decreased MCP-1 mRNA levels in response to IL-1. Oligonucleotides 95-110 C-C motif chemokine ligand 2 Homo sapiens 121-126 7614716-11 1995 Pretreatment with EGTA or the intracellular Ca2+ chelator BAPTA/AM strongly suppressed the strain-induced MCP-1 mRNA. Egtazic Acid 18-22 C-C motif chemokine ligand 2 Homo sapiens 106-111 7644539-0 1995 The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression. acting 8-14 C-C motif chemokine ligand 2 Homo sapiens 123-153 7644539-0 1995 The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression. Phorbol Esters 15-28 C-C motif chemokine ligand 2 Homo sapiens 123-153 7644539-0 1995 The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression. Tetradecanoylphorbol Acetate 30-66 C-C motif chemokine ligand 2 Homo sapiens 123-153 7614716-11 1995 Pretreatment with EGTA or the intracellular Ca2+ chelator BAPTA/AM strongly suppressed the strain-induced MCP-1 mRNA. 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid 58-63 C-C motif chemokine ligand 2 Homo sapiens 106-111 7614716-12 1995 Verapamil, a Ca2+ channel blocker, greatly reduced MCP-1 mRNA levels in both strained and unstrained ECs. Verapamil 0-9 C-C motif chemokine ligand 2 Homo sapiens 51-56 7539030-9 1995 Both MCP-1 and MIP-1 alpha are expressed in a time-dependent manner after bleomycin challenge, and passive immunization of these animals with either anti-MIP-1 alpha or anti-MCP-1 antibodies attenuated leukocyte accumulation. Bleomycin 74-83 C-C motif chemokine ligand 2 Homo sapiens 5-10 7564103-0 1995 Human mesangial cell production of monocyte chemoattractant protein-1: modulation by lovastatin. Lovastatin 85-95 C-C motif chemokine ligand 2 Homo sapiens 35-69 7564103-4 1995 Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase by lovastatin resulted in a reduction of the mesangial cell-derived chemotactic activity as well as MCP-1 mRNA expression. Lovastatin 75-85 C-C motif chemokine ligand 2 Homo sapiens 172-177 7564103-5 1995 The inhibitory effects of lovastatin in the presence of exogenous cholesterol were reversed by mevalonate, suggesting a role for isoprenoid intermediates of the mevalonate pathway and/or isoprenylated proteins in mesangial cell MCP-1 regulation. Lovastatin 26-36 C-C motif chemokine ligand 2 Homo sapiens 228-233 7564103-5 1995 The inhibitory effects of lovastatin in the presence of exogenous cholesterol were reversed by mevalonate, suggesting a role for isoprenoid intermediates of the mevalonate pathway and/or isoprenylated proteins in mesangial cell MCP-1 regulation. Mevalonic Acid 95-105 C-C motif chemokine ligand 2 Homo sapiens 228-233 7758169-0 1995 Nitric oxide modulates the expression of monocyte chemoattractant protein 1 in cultured human endothelial cells. Nitric Oxide 0-12 C-C motif chemokine ligand 2 Homo sapiens 41-75 7758169-3 1995 Inhibition of basal NO production by NG-nitro-L-arginine (L-NAG) upregulates endothelial MCP-1 mRNA expression (250 +/- 20%) and protein secretion. Nitroarginine 37-56 C-C motif chemokine ligand 2 Homo sapiens 89-94 7759884-8 1995 MCP-1 desensitized transfected HEK-293 cells expressing the MCP-1 receptor to activation by MCP-3 in the calcium mobilization assay, but MCP-3 did not effectively desensitize these cells to MCP-1. Calcium 105-112 C-C motif chemokine ligand 2 Homo sapiens 60-65 7539030-13 1995 Our work has clearly established that the C-C chemokines MCP-1 and MIP-1 alpha are expressed and contribute to the initiation and maintenance of the bleomycin-induced pulmonary lesion. Bleomycin 149-158 C-C motif chemokine ligand 2 Homo sapiens 57-62 9977433-0 1995 Magnetic properties of CocMn1-cCl2-FeCl3 graphite bi-intercalation compounds. ferric chloride 35-40 C-C motif chemokine ligand 2 Homo sapiens 30-34 7540203-9 1995 These results suggested that MCAF is one of the important mediators causing histamine release in the late phase reaction and in protracted inflammation of the nasal mucosa. Histamine 76-85 C-C motif chemokine ligand 2 Homo sapiens 29-33 9977433-0 1995 Magnetic properties of CocMn1-cCl2-FeCl3 graphite bi-intercalation compounds. Graphite 41-49 C-C motif chemokine ligand 2 Homo sapiens 30-34 7852846-2 1995 MCAF alone did not induce monocyte-mediated cytotoxicity against human melanoma (A375-M) cells whereas it significantly enhanced the cytotoxicity by norMDP-stimulated monocytes. N-acetyl-nor-muramyl-L-alanyl-D-isoglutamine 149-155 C-C motif chemokine ligand 2 Homo sapiens 0-4 7856691-5 1995 The de novo secretion of monocyte chemotactic protein-1 in the culture supernatants was analyzed by immunoprecipitation and electrophoresis after metabolic labeling with sulfur 35-labeled cysteine. Sulfur 170-176 C-C motif chemokine ligand 2 Homo sapiens 25-55 7856691-5 1995 The de novo secretion of monocyte chemotactic protein-1 in the culture supernatants was analyzed by immunoprecipitation and electrophoresis after metabolic labeling with sulfur 35-labeled cysteine. Cysteine 188-196 C-C motif chemokine ligand 2 Homo sapiens 25-55 7531729-1 1995 Monocyte chemotactic and activating factor (MCAF) is the most potent cytokine that activates basophils to release histamine. Histamine 114-123 C-C motif chemokine ligand 2 Homo sapiens 0-42 7531729-1 1995 Monocyte chemotactic and activating factor (MCAF) is the most potent cytokine that activates basophils to release histamine. Histamine 114-123 C-C motif chemokine ligand 2 Homo sapiens 44-48 7531729-3 1995 Simultaneous addition of MCAF and any of the chemokines studied evoked an augmented response as measured by histamine release, whereas preincubation of leukocytes or purified basophils (80%) with these chemokines decreased MCAF-induced histamine release in a dose-dependent manner. Histamine 108-117 C-C motif chemokine ligand 2 Homo sapiens 25-29 7531729-3 1995 Simultaneous addition of MCAF and any of the chemokines studied evoked an augmented response as measured by histamine release, whereas preincubation of leukocytes or purified basophils (80%) with these chemokines decreased MCAF-induced histamine release in a dose-dependent manner. Histamine 236-245 C-C motif chemokine ligand 2 Homo sapiens 25-29 7531729-10 1995 We have therefore characterized RANTES, MIP-1 alpha, MIP-1 beta, CTAP III, PF4, IL-8, and IP-10 as inhibitors of MCAF-induced histamine release. Histamine 126-135 C-C motif chemokine ligand 2 Homo sapiens 113-117 7890708-2 1995 In human 293 cells stably transfected with the MCP-1 receptor, MCP-1 bound specifically with high affinity (Kd = 260 pM) and induced a rapid mobilization of calcium from intracellular stores. Calcium 157-164 C-C motif chemokine ligand 2 Homo sapiens 47-52 7843438-8 1995 MAIN OUTCOME MEASURES: De novo secretion of MCP-1 in the culture supernatant by immunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis after metabolic labeling with 35S-cysteine. 35s-cysteine 192-204 C-C motif chemokine ligand 2 Homo sapiens 44-49 7861699-6 1994 However, while inhibition of PKC activity completely blocked phorbol-induced MCP-1 up-regulation, induction by IL-1 was not prevented. phorbol 61-68 C-C motif chemokine ligand 2 Homo sapiens 77-82 7891669-0 1994 Functional role of the cis-acting elements in human monocyte chemotactic protein-1 gene in the regulation of its expression by phorbol ester in human glioblastoma cells. Phorbol Esters 127-140 C-C motif chemokine ligand 2 Homo sapiens 52-82 7891669-2 1994 The expression of MCP-1 gene can be induced by lipopolysaccharides (LPS), phorbol esters (TPA) and several cytokines. Phorbol Esters 74-88 C-C motif chemokine ligand 2 Homo sapiens 18-23 7891669-2 1994 The expression of MCP-1 gene can be induced by lipopolysaccharides (LPS), phorbol esters (TPA) and several cytokines. Tetradecanoylphorbol Acetate 90-93 C-C motif chemokine ligand 2 Homo sapiens 18-23 7891669-4 1994 We tested whether the two putative TPA-responsive elements (TREs) and one kappa B enhancer-like region found in the MCP-1 promoter region, are involved in this regulation of MCP-1 gene expression. Tetradecanoylphorbol Acetate 35-38 C-C motif chemokine ligand 2 Homo sapiens 174-179 7891669-5 1994 The 5" untranslated region of MCP-1 gene was linked to chloramphenicol acetyl transferase (CAT) reporter gene and transfected into human glioblastoma cells in which endogenous MCP gene expression was found to be stimulated by TPA and tumor necrosis factor-alpha (TNF-alpha). Tetradecanoylphorbol Acetate 226-229 C-C motif chemokine ligand 2 Homo sapiens 30-35 7891669-6 1994 The 128 bp 5"-flanking region containing one TRE was adequate for basal promoter activity but the presence of both TREs in the MCP-1 promoter region were needed to give TPA responsive enhancement (2.5 fold) of expression of the marker gene. Tetradecanoylphorbol Acetate 169-172 C-C motif chemokine ligand 2 Homo sapiens 127-132 7957666-3 1994 Nuclear run-on assay demonstrated that this cell density-dependent expression of MCP-1 mRNA was regulated at the transcriptional level, and protein tyrosine kinase (PTK) inhibitors, genistein and herbimycin A, completely abrogated this gene transcription. Genistein 182-191 C-C motif chemokine ligand 2 Homo sapiens 81-86 7957666-3 1994 Nuclear run-on assay demonstrated that this cell density-dependent expression of MCP-1 mRNA was regulated at the transcriptional level, and protein tyrosine kinase (PTK) inhibitors, genistein and herbimycin A, completely abrogated this gene transcription. herbimycin 196-208 C-C motif chemokine ligand 2 Homo sapiens 81-86 7957666-5 1994 Cell density regulated tyrosine phosphorylation of 70-kDa protein in parallel with alterations in MCP-1 mRNA expression. Tyrosine 23-31 C-C motif chemokine ligand 2 Homo sapiens 98-103 7957666-8 1994 It is also suggested that PKC activity plays a critical role in tyrosine phosphorylation of 70-kDa protein, which may mediate signals regulating the cell density-dependent expression of the MCP-1 gene. Tyrosine 64-72 C-C motif chemokine ligand 2 Homo sapiens 190-195 9975418-0 1994 Magnetic properties of CocNi1-cCl2-FeCl3 graphite bi-intercalation compounds. Graphite 41-49 C-C motif chemokine ligand 2 Homo sapiens 30-34 7523503-10 1994 The C-terminal residues 62 to 67 on human MCP-1 molecules seem to be critical to express the epitope recognized by the neutralizing 2H5 anti-MCP-1 mAb. 3-Deoxy-3-Fluoro-Beta-D-Galactopyranose 132-135 C-C motif chemokine ligand 2 Homo sapiens 42-47 7523503-10 1994 The C-terminal residues 62 to 67 on human MCP-1 molecules seem to be critical to express the epitope recognized by the neutralizing 2H5 anti-MCP-1 mAb. 3-Deoxy-3-Fluoro-Beta-D-Galactopyranose 132-135 C-C motif chemokine ligand 2 Homo sapiens 141-146 7768330-5 1995 MCP-1 mRNA was readily detected by northern analysis of total RNA isolated from human endometrial tissue (n = 39 tissues from ovulatory women; n = 3 atrophic endometria from anovulatory women; n = 6 from women ingesting oral contraceptives or medroxyprogesterone acetate) and decidua parietalis at midtrimester (n = 6 pregnancies) and at term (n = 6 pregnancies). Medroxyprogesterone Acetate 243-270 C-C motif chemokine ligand 2 Homo sapiens 0-5 7832810-1 1995 The Sf-9 insect cells infected with a recombinant baculovirus integrated with a cDNA encoding human monocyte chemoattractant protein-1 (MCP-1) produced three different MCP-1s, which were isolated by reverse-phase HPLC as 13kDa, 14kDa, and 15kDa bands on SDS-PAGE. Sodium Dodecyl Sulfate 254-257 C-C motif chemokine ligand 2 Homo sapiens 100-134 7832810-1 1995 The Sf-9 insect cells infected with a recombinant baculovirus integrated with a cDNA encoding human monocyte chemoattractant protein-1 (MCP-1) produced three different MCP-1s, which were isolated by reverse-phase HPLC as 13kDa, 14kDa, and 15kDa bands on SDS-PAGE. Sodium Dodecyl Sulfate 254-257 C-C motif chemokine ligand 2 Homo sapiens 136-141 7832810-2 1995 The heterogeneity between these MCP-1s was ascribed to the different degree of O-glycosylation with Gal beta 1-3GalNAc beta 1-Ser/Thr, while the 13kDa was regarded as carbohydrate-free. gal beta 1-3galnac beta 1-ser 100-129 C-C motif chemokine ligand 2 Homo sapiens 32-37 7832810-2 1995 The heterogeneity between these MCP-1s was ascribed to the different degree of O-glycosylation with Gal beta 1-3GalNAc beta 1-Ser/Thr, while the 13kDa was regarded as carbohydrate-free. Threonine 130-133 C-C motif chemokine ligand 2 Homo sapiens 32-37 7832810-2 1995 The heterogeneity between these MCP-1s was ascribed to the different degree of O-glycosylation with Gal beta 1-3GalNAc beta 1-Ser/Thr, while the 13kDa was regarded as carbohydrate-free. Carbohydrates 167-179 C-C motif chemokine ligand 2 Homo sapiens 32-37 8679249-0 1995 Monocyte chemotactic protein-1 (MCP-1) mRNA is down-regulated in human dermal fibroblasts by dexamethasone: differential regulation by TGF-beta. Dexamethasone 93-106 C-C motif chemokine ligand 2 Homo sapiens 0-30 8679249-0 1995 Monocyte chemotactic protein-1 (MCP-1) mRNA is down-regulated in human dermal fibroblasts by dexamethasone: differential regulation by TGF-beta. Dexamethasone 93-106 C-C motif chemokine ligand 2 Homo sapiens 32-37 8679249-4 1995 Treatment of serum stimulated dermal fibroblasts with dexamethasone led to a dose dependent down-regulation of MCP-1 mRNA levels. Dexamethasone 54-67 C-C motif chemokine ligand 2 Homo sapiens 111-116 8679249-7 1995 TGF-beta treatment of fibroblasts cultured in serum also partially overcame the dexamethasone mediated decrease in MCP-1 mRNA levels. Dexamethasone 80-93 C-C motif chemokine ligand 2 Homo sapiens 115-120 7525719-9 1994 Subsequently, we observed that MIP-1 alpha, MCP-1, and RANTES, but not MIP-1 beta, enhance the binding of guanosine 5"-O-(thiotriphosphate), and increase the hydrolysis of [32P]GTP in IANK cell membranes. guanosine 5"-o- 106-121 C-C motif chemokine ligand 2 Homo sapiens 44-49 7525719-9 1994 Subsequently, we observed that MIP-1 alpha, MCP-1, and RANTES, but not MIP-1 beta, enhance the binding of guanosine 5"-O-(thiotriphosphate), and increase the hydrolysis of [32P]GTP in IANK cell membranes. thiotriphosphate 122-138 C-C motif chemokine ligand 2 Homo sapiens 44-49 7525719-9 1994 Subsequently, we observed that MIP-1 alpha, MCP-1, and RANTES, but not MIP-1 beta, enhance the binding of guanosine 5"-O-(thiotriphosphate), and increase the hydrolysis of [32P]GTP in IANK cell membranes. Phosphorus-32 173-176 C-C motif chemokine ligand 2 Homo sapiens 44-49 7525719-9 1994 Subsequently, we observed that MIP-1 alpha, MCP-1, and RANTES, but not MIP-1 beta, enhance the binding of guanosine 5"-O-(thiotriphosphate), and increase the hydrolysis of [32P]GTP in IANK cell membranes. Guanosine Triphosphate 177-180 C-C motif chemokine ligand 2 Homo sapiens 44-49 7919389-0 1994 Monocyte chemoattractant protein-1 gene is expressed in activated neutrophils and retinoic acid-induced human myeloid cell lines. Tretinoin 82-95 C-C motif chemokine ligand 2 Homo sapiens 0-34 7919389-2 1994 Three of the cDNAs cloned hybridized to RA-inducible transcripts on Northern blots, one of which was shown to encode sequences for monocyte chemoattractant protein-1 (MCP-1), a recently described cytokine that is chemotactic for monocytes but not for neutrophils. Tretinoin 40-42 C-C motif chemokine ligand 2 Homo sapiens 131-165 7919389-2 1994 Three of the cDNAs cloned hybridized to RA-inducible transcripts on Northern blots, one of which was shown to encode sequences for monocyte chemoattractant protein-1 (MCP-1), a recently described cytokine that is chemotactic for monocytes but not for neutrophils. Tretinoin 40-42 C-C motif chemokine ligand 2 Homo sapiens 167-172 7919389-4 1994 MCP-1 transcript levels also increased after RA treatment of the NB4 acute promyelocytic cell line. Tretinoin 45-47 C-C motif chemokine ligand 2 Homo sapiens 0-5 7861699-5 1994 Activation of protein kinase C (PKC) by phorbol esters or diacyglycerol up-regulated mesangial MCP-1 message and bioactivity in a fashion similar to IL-1. Phorbol Esters 40-54 C-C motif chemokine ligand 2 Homo sapiens 95-100 7861699-5 1994 Activation of protein kinase C (PKC) by phorbol esters or diacyglycerol up-regulated mesangial MCP-1 message and bioactivity in a fashion similar to IL-1. diacyglycerol 58-71 C-C motif chemokine ligand 2 Homo sapiens 95-100 7861699-8 1994 Furthermore, increasing intracellular cAMP and activating PKA attenuated basal MCP-1 mRNA levels by 82% and blocked IL-1 induced MCP-1 expression by 88%. Cyclic AMP 38-42 C-C motif chemokine ligand 2 Homo sapiens 79-84 7861699-8 1994 Furthermore, increasing intracellular cAMP and activating PKA attenuated basal MCP-1 mRNA levels by 82% and blocked IL-1 induced MCP-1 expression by 88%. Cyclic AMP 38-42 C-C motif chemokine ligand 2 Homo sapiens 129-134 7861699-10 1994 The structurally distinct protein tyrosine kinase (PTK) inhibitors genistein, herbimycin A, and tyrphostin each caused a dose-dependent inhibition of the effects of IL-1 on mesangial MCP-1 activity. Genistein 67-76 C-C motif chemokine ligand 2 Homo sapiens 183-188 7861699-10 1994 The structurally distinct protein tyrosine kinase (PTK) inhibitors genistein, herbimycin A, and tyrphostin each caused a dose-dependent inhibition of the effects of IL-1 on mesangial MCP-1 activity. herbimycin 78-90 C-C motif chemokine ligand 2 Homo sapiens 183-188 7861699-10 1994 The structurally distinct protein tyrosine kinase (PTK) inhibitors genistein, herbimycin A, and tyrphostin each caused a dose-dependent inhibition of the effects of IL-1 on mesangial MCP-1 activity. Tyrphostins 96-106 C-C motif chemokine ligand 2 Homo sapiens 183-188 8083528-9 1994 Monocytes or monocyte tumor cells produce MCP-1 and/or IL-8 in response to cytokines, virus, double stranded RNA, bacterial endotoxin, mitogen or phorbol ester. Phorbol Esters 146-159 C-C motif chemokine ligand 2 Homo sapiens 42-47 8051410-2 1994 We initially found that the effects of various stimuli, including IL-1 beta, TNF-alpha, and 2-O-tetradecanoylphorbol 13-acetate, on the expression of hMCP-1 mRNA were quite different among A172 glioblastoma cells, HT1080 fibrosarcoma cells, and SKLMS1 leiomyosarcoma cells. 2-o-tetradecanoylphorbol 13-acetate 92-127 C-C motif chemokine ligand 2 Homo sapiens 150-156 8195191-2 1994 In this study, we have elucidated the structure of this novel adduct with the use of mass spectrometry, as well as 1H and 13C NMR as a substitution product of a -C(Cl) = CCl2 moiety for a beta-hydrogen atom on the prosthetic heme"s ring I vinyl group. Hydrogen 115-117 C-C motif chemokine ligand 2 Homo sapiens 170-174 8195247-12 1994 (Another carboxyl-terminal insertional mutation demonstrated that O-linked carbohydrate in MCP-1 alpha may be added to a threonine in the carboxyl-terminal region.) o-linked carbohydrate 66-87 C-C motif chemokine ligand 2 Homo sapiens 91-96 8195247-12 1994 (Another carboxyl-terminal insertional mutation demonstrated that O-linked carbohydrate in MCP-1 alpha may be added to a threonine in the carboxyl-terminal region.) Threonine 121-130 C-C motif chemokine ligand 2 Homo sapiens 91-96 8195191-2 1994 In this study, we have elucidated the structure of this novel adduct with the use of mass spectrometry, as well as 1H and 13C NMR as a substitution product of a -C(Cl) = CCl2 moiety for a beta-hydrogen atom on the prosthetic heme"s ring I vinyl group. 13c 122-125 C-C motif chemokine ligand 2 Homo sapiens 170-174 8195191-2 1994 In this study, we have elucidated the structure of this novel adduct with the use of mass spectrometry, as well as 1H and 13C NMR as a substitution product of a -C(Cl) = CCl2 moiety for a beta-hydrogen atom on the prosthetic heme"s ring I vinyl group. Hydrogen 193-201 C-C motif chemokine ligand 2 Homo sapiens 170-174 8195191-2 1994 In this study, we have elucidated the structure of this novel adduct with the use of mass spectrometry, as well as 1H and 13C NMR as a substitution product of a -C(Cl) = CCl2 moiety for a beta-hydrogen atom on the prosthetic heme"s ring I vinyl group. Heme 225-229 C-C motif chemokine ligand 2 Homo sapiens 170-174 8200045-5 1994 When the MLR was performed in the presence of NMA (500 microM), the production of IL-8 increased twofold (P < 0.05) and ENA-78 increased fivefold (P < 0.05), while MCP-1 and MIP-1 alpha were not significantly altered. nma 46-49 C-C motif chemokine ligand 2 Homo sapiens 170-175 7800953-5 1994 In vitro experiments with KS-derived cell cultures, which most likely represent the KS spindle cells, suggested that liposomal doxorubicin may cause regression of KS via two different mechanisms: (i) by highly specific inhibition of KS spindle cell proliferation and (ii) by induction of monocyte chemoattractant protein-1 expression in KS spindle cells, which may result in increased recruitment of phagocytic cells (monocytes/macrophages) into the lesions. Doxorubicin 127-138 C-C motif chemokine ligand 2 Homo sapiens 288-322 7515094-2 1994 All three chemokines tested, MCP-1, MIP-1 alpha, and RANTES, elicited mobilization of intracellular free calcium in monocytes and THP-1 cells. Calcium 105-112 C-C motif chemokine ligand 2 Homo sapiens 29-34 8178946-11 1994 Actinomycin D experiments indicated that induction of MCP-1 by thrombin in PBMC and EC was gene transcription dependent. Dactinomycin 0-13 C-C motif chemokine ligand 2 Homo sapiens 54-59 8189067-7 1994 Induction of MCP-1 and MCP-2 in human diploid fibroblasts and peripheral blood leukocytes as well as osteosarcoma, epidermal carcinoma, and melanoma cells by the cytokines IL-1 beta, IFN-beta, and IFN-gamma and cytokine inducers such as dsRNA, virus, endotoxin, mitogen, and phorbol ester was studied. Phorbol Esters 275-288 C-C motif chemokine ligand 2 Homo sapiens 13-18 8188667-7 1994 We find that methyl-prednisolone reduces MCP-1 but not other chemokine transcripts in HMC-1, even though there are distinct and more general effects on chemokine transcripts in activated T-cells. Methylprednisolone 13-32 C-C motif chemokine ligand 2 Homo sapiens 41-46 7510961-1 1994 Monocyte Chemotactic Protein(MCP)-1 and other members of the C-C branch of the chemokine superfamily (RANTES, MIP1 alpha/LD78, and MCP-3) induced, at chemotactic concentrations, the release of [3H]arachidonic acid in prelabeled human monocytes. Tritium 194-196 C-C motif chemokine ligand 2 Homo sapiens 9-35 8144937-2 1994 MCP-2 and MCP-3 are recently identified members of the Cys-Cys chemokine family with high sequence similarity with MCP-1 (62% and 71%, respectively). cysteinylcysteine 55-62 C-C motif chemokine ligand 2 Homo sapiens 115-120 8144937-9 1994 MCP-1-, MCP-2-, and MCP-3-induced chemotactic responses were blocked by C-I, a serine/threonine kinase inhibitor, and by genistein, a tyrosine kinase inhibitor, with the MCP-2 response being more sensitive than those induced by MCP-1 and MCP-3. Genistein 121-130 C-C motif chemokine ligand 2 Homo sapiens 0-5 8144937-9 1994 MCP-1-, MCP-2-, and MCP-3-induced chemotactic responses were blocked by C-I, a serine/threonine kinase inhibitor, and by genistein, a tyrosine kinase inhibitor, with the MCP-2 response being more sensitive than those induced by MCP-1 and MCP-3. Genistein 121-130 C-C motif chemokine ligand 2 Homo sapiens 228-233 8144937-10 1994 MCP-1 and MCP-3 rapidly induced arachidonic acid release whereas MCP-2 was ineffective. Arachidonic Acid 32-48 C-C motif chemokine ligand 2 Homo sapiens 0-5 7510961-1 1994 Monocyte Chemotactic Protein(MCP)-1 and other members of the C-C branch of the chemokine superfamily (RANTES, MIP1 alpha/LD78, and MCP-3) induced, at chemotactic concentrations, the release of [3H]arachidonic acid in prelabeled human monocytes. Arachidonic Acid 197-213 C-C motif chemokine ligand 2 Homo sapiens 9-35 8031999-8 1994 Of three disease-modifying drugs tested, dexamethasone and gold sodium thiomalate (GST) inhibited the production of IL-8 and MCP-1, while methotrexate (MTX) was inactive. Dexamethasone 41-54 C-C motif chemokine ligand 2 Homo sapiens 125-130 8031999-8 1994 Of three disease-modifying drugs tested, dexamethasone and gold sodium thiomalate (GST) inhibited the production of IL-8 and MCP-1, while methotrexate (MTX) was inactive. sodium thiomalate 64-81 C-C motif chemokine ligand 2 Homo sapiens 125-130 8031999-8 1994 Of three disease-modifying drugs tested, dexamethasone and gold sodium thiomalate (GST) inhibited the production of IL-8 and MCP-1, while methotrexate (MTX) was inactive. Gold Sodium Thiomalate 83-86 C-C motif chemokine ligand 2 Homo sapiens 125-130 8031999-9 1994 Dexamethasone reduced the production of MCP-1 and IL-8 by 20-65% and 60-80%, respectively, whilst GST inhibited MCP-1 and IL-8 synthesis in suboptimally, but not in optimally stimulated synoviocytes. Dexamethasone 0-13 C-C motif chemokine ligand 2 Homo sapiens 40-45 8031999-10 1994 Taken together, these results show that the production of MCP-1 and IL-8 is similarly affected by anti-rheumatic drugs and that dexamethasone is the most potent inhibitor suggesting that part of the anti-rheumatic action of glucocorticoids is due to prevention of accumulation of chemotactic cytokines acting on neutrophils and monocytes. Dexamethasone 128-141 C-C motif chemokine ligand 2 Homo sapiens 58-63 8299114-3 1994 We now demonstrate that L-MTP-PE also induces monocyte chemotactic and activating factor (MCAF) mRNA expression at both the transcriptional and post-transcriptional levels. L-MTP-PE 24-32 C-C motif chemokine ligand 2 Homo sapiens 90-94 8290256-5 1994 Two mutations were identified in the p53 cDNA from HC11 cells: a missense mutation at codon 138, substituting Trp for Cys, and a microdeletion, codon 123 to 130, of exon 5. Tryptophan 110-113 C-C motif chemokine ligand 2 Homo sapiens 51-55 8290256-5 1994 Two mutations were identified in the p53 cDNA from HC11 cells: a missense mutation at codon 138, substituting Trp for Cys, and a microdeletion, codon 123 to 130, of exon 5. Cysteine 118-121 C-C motif chemokine ligand 2 Homo sapiens 51-55 8106442-0 1994 Rapid induction of arachidonic acid release by monocyte chemotactic protein-1 and related chemokines. Arachidonic Acid 19-35 C-C motif chemokine ligand 2 Homo sapiens 47-77 8106442-2 1994 Monocyte Chemotactic Protein-1 (MCP-1), a member of the Cys-Cys branch of the chemokine superfamily, induced a mepacrine- and manoalide-sensitive increase in the release of [3H]arachidonic acid from prelabeled human monocytes and monocytic THP-1 leukemic cells. cysteinylcysteine 56-63 C-C motif chemokine ligand 2 Homo sapiens 0-30 8106442-2 1994 Monocyte Chemotactic Protein-1 (MCP-1), a member of the Cys-Cys branch of the chemokine superfamily, induced a mepacrine- and manoalide-sensitive increase in the release of [3H]arachidonic acid from prelabeled human monocytes and monocytic THP-1 leukemic cells. cysteinylcysteine 56-63 C-C motif chemokine ligand 2 Homo sapiens 32-37 8106442-2 1994 Monocyte Chemotactic Protein-1 (MCP-1), a member of the Cys-Cys branch of the chemokine superfamily, induced a mepacrine- and manoalide-sensitive increase in the release of [3H]arachidonic acid from prelabeled human monocytes and monocytic THP-1 leukemic cells. Quinacrine 111-120 C-C motif chemokine ligand 2 Homo sapiens 0-30 8106442-2 1994 Monocyte Chemotactic Protein-1 (MCP-1), a member of the Cys-Cys branch of the chemokine superfamily, induced a mepacrine- and manoalide-sensitive increase in the release of [3H]arachidonic acid from prelabeled human monocytes and monocytic THP-1 leukemic cells. Quinacrine 111-120 C-C motif chemokine ligand 2 Homo sapiens 32-37 8106442-2 1994 Monocyte Chemotactic Protein-1 (MCP-1), a member of the Cys-Cys branch of the chemokine superfamily, induced a mepacrine- and manoalide-sensitive increase in the release of [3H]arachidonic acid from prelabeled human monocytes and monocytic THP-1 leukemic cells. manoalide 126-135 C-C motif chemokine ligand 2 Homo sapiens 0-30 8106442-2 1994 Monocyte Chemotactic Protein-1 (MCP-1), a member of the Cys-Cys branch of the chemokine superfamily, induced a mepacrine- and manoalide-sensitive increase in the release of [3H]arachidonic acid from prelabeled human monocytes and monocytic THP-1 leukemic cells. manoalide 126-135 C-C motif chemokine ligand 2 Homo sapiens 32-37 8106442-2 1994 Monocyte Chemotactic Protein-1 (MCP-1), a member of the Cys-Cys branch of the chemokine superfamily, induced a mepacrine- and manoalide-sensitive increase in the release of [3H]arachidonic acid from prelabeled human monocytes and monocytic THP-1 leukemic cells. [3h]arachidonic acid 173-193 C-C motif chemokine ligand 2 Homo sapiens 0-30 8106442-2 1994 Monocyte Chemotactic Protein-1 (MCP-1), a member of the Cys-Cys branch of the chemokine superfamily, induced a mepacrine- and manoalide-sensitive increase in the release of [3H]arachidonic acid from prelabeled human monocytes and monocytic THP-1 leukemic cells. [3h]arachidonic acid 173-193 C-C motif chemokine ligand 2 Homo sapiens 32-37 8106442-6 1994 However, using ionophore-permeabilized monocytes and controlled intracellular Ca2+ concentration it was possible to dissociate MCP-1-induced Ca2+ influx from [3H]arachidonic acid release. Tritium 159-161 C-C motif chemokine ligand 2 Homo sapiens 127-132 8106442-6 1994 However, using ionophore-permeabilized monocytes and controlled intracellular Ca2+ concentration it was possible to dissociate MCP-1-induced Ca2+ influx from [3H]arachidonic acid release. Arachidonic Acid 162-178 C-C motif chemokine ligand 2 Homo sapiens 127-132 8106442-7 1994 Thus, the MCP-1-induced increase in [Ca2+]i is necessary but not sufficient for arachidonic acid accumulation. Arachidonic Acid 80-96 C-C motif chemokine ligand 2 Homo sapiens 10-15 8106442-8 1994 Phospholipase A2 inhibitors (mepacrine, p-bromophenacyl bromide, and manoalide) blocked monocyte polarization and chemotaxis induced by MCP-1. Quinacrine 29-38 C-C motif chemokine ligand 2 Homo sapiens 136-141 8106442-8 1994 Phospholipase A2 inhibitors (mepacrine, p-bromophenacyl bromide, and manoalide) blocked monocyte polarization and chemotaxis induced by MCP-1. 4-bromophenacyl bromide 40-63 C-C motif chemokine ligand 2 Homo sapiens 136-141 8106442-8 1994 Phospholipase A2 inhibitors (mepacrine, p-bromophenacyl bromide, and manoalide) blocked monocyte polarization and chemotaxis induced by MCP-1. manoalide 69-78 C-C motif chemokine ligand 2 Homo sapiens 136-141 8106442-10 1994 Brief (5 min) pretreatment of monocytes with platelet-activating factor amplified MCP-1-induced arachidonic acid release and, at MCP-1 suboptimal concentrations, synergized in inducing monocyte migration. Arachidonic Acid 96-112 C-C motif chemokine ligand 2 Homo sapiens 82-87 8106442-12 1994 The results presented here show that the Cys-Cys chemokines MCP-1, LD78/MIP1 alpha, and RANTES cause rapid release of arachidonic acid in monocytes and that this may be important in inducing monocyte chemotaxis. cysteinylcysteine 41-48 C-C motif chemokine ligand 2 Homo sapiens 60-65 8106442-12 1994 The results presented here show that the Cys-Cys chemokines MCP-1, LD78/MIP1 alpha, and RANTES cause rapid release of arachidonic acid in monocytes and that this may be important in inducing monocyte chemotaxis. Arachidonic Acid 118-134 C-C motif chemokine ligand 2 Homo sapiens 60-65 8300851-5 1994 Results indicated that MCP-1 mRNA expression was maximal within 3 h, and was further augmented by the protein synthesis inhibitor cycloheximide (CY). Cycloheximide 130-143 C-C motif chemokine ligand 2 Homo sapiens 23-28 8300851-5 1994 Results indicated that MCP-1 mRNA expression was maximal within 3 h, and was further augmented by the protein synthesis inhibitor cycloheximide (CY). Cycloheximide 145-147 C-C motif chemokine ligand 2 Homo sapiens 23-28 8299114-8 1994 We therefore conclude that L-MTP-PE selectively up-regulates MCAF expression in monocytes and that MCAF may play a role in the tumoricidal and immune-stimulating activity of L-MTP-PE. L-MTP-PE 174-182 C-C motif chemokine ligand 2 Homo sapiens 99-103 8299114-0 1994 Liposome-encapsulated muramyl tripeptide up-regulates monocyte chemotactic and activating factor gene expression in human monocytes at the transcriptional and post-transcriptional levels. muramyl 22-29 C-C motif chemokine ligand 2 Homo sapiens 54-96 8299114-0 1994 Liposome-encapsulated muramyl tripeptide up-regulates monocyte chemotactic and activating factor gene expression in human monocytes at the transcriptional and post-transcriptional levels. tripeptide K-26 30-40 C-C motif chemokine ligand 2 Homo sapiens 54-96 8299114-3 1994 We now demonstrate that L-MTP-PE also induces monocyte chemotactic and activating factor (MCAF) mRNA expression at both the transcriptional and post-transcriptional levels. L-MTP-PE 24-32 C-C motif chemokine ligand 2 Homo sapiens 46-88 8299114-8 1994 We therefore conclude that L-MTP-PE selectively up-regulates MCAF expression in monocytes and that MCAF may play a role in the tumoricidal and immune-stimulating activity of L-MTP-PE. L-MTP-PE 27-35 C-C motif chemokine ligand 2 Homo sapiens 61-65 8283136-6 1994 After single-dose treatments with the hepatotoxins carbon tetrachloride and galactosamine, MCP-1 mRNA was detectable beginning at 2 and 4 h after treatment, respectively, and was expressed continuously until 60-72 h. During chronic carbon tetrachloride administration, MCP-1 mRNA levels were elevated for the entire 10 weeks of treatment with peak levels of expression occurring early (weeks 1-3) and late (weeks 8-10) in this model. Carbon Tetrachloride 51-71 C-C motif chemokine ligand 2 Homo sapiens 91-96 8055706-0 1994 In vitro vitamin E and selenium supplementation improves neutrophil-mediated functions and monocyte chemoattractant protein-1 production in the elderly. Vitamin E 9-18 C-C motif chemokine ligand 2 Homo sapiens 91-125 8055706-0 1994 In vitro vitamin E and selenium supplementation improves neutrophil-mediated functions and monocyte chemoattractant protein-1 production in the elderly. Selenium 23-31 C-C motif chemokine ligand 2 Homo sapiens 91-125 8055706-3 1994 By contrast, in vitro vitamin E and selenium supplementation was able to enhance significantly the depressed PMN activities and MCP-1 synthesis. Vitamin E 22-31 C-C motif chemokine ligand 2 Homo sapiens 128-133 8055706-3 1994 By contrast, in vitro vitamin E and selenium supplementation was able to enhance significantly the depressed PMN activities and MCP-1 synthesis. Selenium 36-44 C-C motif chemokine ligand 2 Homo sapiens 128-133 8283136-6 1994 After single-dose treatments with the hepatotoxins carbon tetrachloride and galactosamine, MCP-1 mRNA was detectable beginning at 2 and 4 h after treatment, respectively, and was expressed continuously until 60-72 h. During chronic carbon tetrachloride administration, MCP-1 mRNA levels were elevated for the entire 10 weeks of treatment with peak levels of expression occurring early (weeks 1-3) and late (weeks 8-10) in this model. Galactosamine 76-89 C-C motif chemokine ligand 2 Homo sapiens 269-274 8283136-6 1994 After single-dose treatments with the hepatotoxins carbon tetrachloride and galactosamine, MCP-1 mRNA was detectable beginning at 2 and 4 h after treatment, respectively, and was expressed continuously until 60-72 h. During chronic carbon tetrachloride administration, MCP-1 mRNA levels were elevated for the entire 10 weeks of treatment with peak levels of expression occurring early (weeks 1-3) and late (weeks 8-10) in this model. Carbon Tetrachloride 51-71 C-C motif chemokine ligand 2 Homo sapiens 269-274 8283136-6 1994 After single-dose treatments with the hepatotoxins carbon tetrachloride and galactosamine, MCP-1 mRNA was detectable beginning at 2 and 4 h after treatment, respectively, and was expressed continuously until 60-72 h. During chronic carbon tetrachloride administration, MCP-1 mRNA levels were elevated for the entire 10 weeks of treatment with peak levels of expression occurring early (weeks 1-3) and late (weeks 8-10) in this model. Carbon Tetrachloride 232-252 C-C motif chemokine ligand 2 Homo sapiens 91-96 8283136-6 1994 After single-dose treatments with the hepatotoxins carbon tetrachloride and galactosamine, MCP-1 mRNA was detectable beginning at 2 and 4 h after treatment, respectively, and was expressed continuously until 60-72 h. During chronic carbon tetrachloride administration, MCP-1 mRNA levels were elevated for the entire 10 weeks of treatment with peak levels of expression occurring early (weeks 1-3) and late (weeks 8-10) in this model. Galactosamine 76-89 C-C motif chemokine ligand 2 Homo sapiens 91-96 8225596-1 1993 The present study shows that monocyte chemotactic activity in crevicular fluids increases with severity of the disease and that a monocyte chemoattractant, monocyte chemoattractant protein 1 (MCP-1), is expressed as the predominant cytokine of gingival tissues and their fibroblasts treated with Porphyromonas (Bacteroides) gingivalis lipopolysaccharide (P-LPS). Pyridoxal Phosphate 355-360 C-C motif chemokine ligand 2 Homo sapiens 156-190 8225596-1 1993 The present study shows that monocyte chemotactic activity in crevicular fluids increases with severity of the disease and that a monocyte chemoattractant, monocyte chemoattractant protein 1 (MCP-1), is expressed as the predominant cytokine of gingival tissues and their fibroblasts treated with Porphyromonas (Bacteroides) gingivalis lipopolysaccharide (P-LPS). Pyridoxal Phosphate 355-360 C-C motif chemokine ligand 2 Homo sapiens 192-197 7679430-0 1993 Receptor-activated calcium influx in human monocytes exposed to monocyte chemotactic protein-1 and related cytokines. Calcium 19-26 C-C motif chemokine ligand 2 Homo sapiens 64-94 8335925-7 1993 The levels of MCP-1 and IL-8 protein from mixed lymphocyte reaction supernatants as measured by specific ELISA were positively correlated with the proliferative response as measured by [3H]TdR uptake. Tritium 186-188 C-C motif chemokine ligand 2 Homo sapiens 14-19 8484776-1 1993 Multiple signal transduction pathways including protein kinase C, tyrosine phosphorylation, and an independent third signaling mechanism are involved in the activation of monocyte chemotactic protein-1 gene. Tyrosine 66-74 C-C motif chemokine ligand 2 Homo sapiens 171-201 8484776-2 1993 Northern blot analysis showed that the incubation of endothelial cell with dioctanoylglycerol induced maximum level of monocyte chemotactic protein-1 transcripts. dioctanoylglycerol 75-93 C-C motif chemokine ligand 2 Homo sapiens 119-149 8484776-3 1993 The TPA-induced monocyte chemotactic protein-1 expression was abolished by treating the cells with both staurosporine and genistein; however, only a portion of the LPS-induced expression was inhibited by staurosporine/genistein. Tetradecanoylphorbol Acetate 4-7 C-C motif chemokine ligand 2 Homo sapiens 16-46 8484776-3 1993 The TPA-induced monocyte chemotactic protein-1 expression was abolished by treating the cells with both staurosporine and genistein; however, only a portion of the LPS-induced expression was inhibited by staurosporine/genistein. Staurosporine 104-117 C-C motif chemokine ligand 2 Homo sapiens 16-46 8484776-3 1993 The TPA-induced monocyte chemotactic protein-1 expression was abolished by treating the cells with both staurosporine and genistein; however, only a portion of the LPS-induced expression was inhibited by staurosporine/genistein. Genistein 122-131 C-C motif chemokine ligand 2 Homo sapiens 16-46 8484776-3 1993 The TPA-induced monocyte chemotactic protein-1 expression was abolished by treating the cells with both staurosporine and genistein; however, only a portion of the LPS-induced expression was inhibited by staurosporine/genistein. Genistein 218-227 C-C motif chemokine ligand 2 Homo sapiens 16-46 7680615-2 1993 We have studied the effects of four CC-chemokines and show that MCP-1, RANTES (regulated on activation, normal T expressed and secreted) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) are potent basophil agonists inducing a rapid change of cytosolic free calcium ([Ca2+]i), the release of histamine and sulfido-leukotrienes, and chemotaxis. Calcium 266-273 C-C motif chemokine ligand 2 Homo sapiens 64-69 7680615-2 1993 We have studied the effects of four CC-chemokines and show that MCP-1, RANTES (regulated on activation, normal T expressed and secreted) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) are potent basophil agonists inducing a rapid change of cytosolic free calcium ([Ca2+]i), the release of histamine and sulfido-leukotrienes, and chemotaxis. Histamine 300-309 C-C motif chemokine ligand 2 Homo sapiens 64-69 7680615-2 1993 We have studied the effects of four CC-chemokines and show that MCP-1, RANTES (regulated on activation, normal T expressed and secreted) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) are potent basophil agonists inducing a rapid change of cytosolic free calcium ([Ca2+]i), the release of histamine and sulfido-leukotrienes, and chemotaxis. sulfido-leukotrienes 314-334 C-C motif chemokine ligand 2 Homo sapiens 64-69 7679707-5 1993 Although MCAF and MIP-1 alpha competed for RANTES binding to monocytes with apparent lower affinity (with estimated Kd of 6 and 1.6, nM respectively) both of these cytokines effectively desensitized the calcium mobilization induced by RANTES. Calcium 203-210 C-C motif chemokine ligand 2 Homo sapiens 9-13 7679699-5 1993 Both MCAF/MCP-1 and RANTES are present in conditioned mononuclear cell media and can be separated using Mono Q anion exchange chromatography. Mono Q 104-110 C-C motif chemokine ligand 2 Homo sapiens 10-15 8450051-1 1993 Addition of leumedin, N-[9H-(2,7-dimethylfluorenyl-9-methoxy) carbon]-L-leucine at 30-60 microM together with LDL almost completely prevented the induction of monocyte chemotactic protein mRNA, reduced monocyte chemotactic protein 1 levels by 84%, and inhibited monocyte migration into the subendothelial space of cocultures of human aortic wall cells by < or = 98%. Leumedin 12-20 C-C motif chemokine ligand 2 Homo sapiens 202-232 8450051-1 1993 Addition of leumedin, N-[9H-(2,7-dimethylfluorenyl-9-methoxy) carbon]-L-leucine at 30-60 microM together with LDL almost completely prevented the induction of monocyte chemotactic protein mRNA, reduced monocyte chemotactic protein 1 levels by 84%, and inhibited monocyte migration into the subendothelial space of cocultures of human aortic wall cells by < or = 98%. n-[9h-(2,7-dimethylfluorenyl-9-methoxy) carbon]-l-leucine 22-79 C-C motif chemokine ligand 2 Homo sapiens 202-232 7679430-3 1993 Agonist-stimulated Ca2+ influx was demonstrated directly by the use of Mn2+: in the presence of extracellular Mn2+, MCP-1 and FMLP stimulated a dose-dependent quench in fluorescence of Fura-2-loaded monocytes. Manganese(2+) 71-75 C-C motif chemokine ligand 2 Homo sapiens 116-121 7679430-3 1993 Agonist-stimulated Ca2+ influx was demonstrated directly by the use of Mn2+: in the presence of extracellular Mn2+, MCP-1 and FMLP stimulated a dose-dependent quench in fluorescence of Fura-2-loaded monocytes. Manganese(2+) 110-114 C-C motif chemokine ligand 2 Homo sapiens 116-121 7679430-3 1993 Agonist-stimulated Ca2+ influx was demonstrated directly by the use of Mn2+: in the presence of extracellular Mn2+, MCP-1 and FMLP stimulated a dose-dependent quench in fluorescence of Fura-2-loaded monocytes. Fura-2 185-191 C-C motif chemokine ligand 2 Homo sapiens 116-121 7679430-9 1993 In addition to MCP-1, also two other members of the chemokine Cys-Cys family, RANTES and MIP-1 alpha, stimulated [Ca2+]i increase. cysteinylcysteine 62-69 C-C motif chemokine ligand 2 Homo sapiens 15-20 7942299-10 1993 Composition of the culture medium was especially critical for LPS-induced secretion of MCP-1, which was greatly enhanced by FCS and by Iscove"s DMEM compared to RPMI 1640. dmem 144-148 C-C motif chemokine ligand 2 Homo sapiens 87-92 7942299-10 1993 Composition of the culture medium was especially critical for LPS-induced secretion of MCP-1, which was greatly enhanced by FCS and by Iscove"s DMEM compared to RPMI 1640. rpmi 1640 161-170 C-C motif chemokine ligand 2 Homo sapiens 87-92 1443157-7 1992 Furthermore, we showed the dose- and time-dependent suppression of IL-1 beta-stimulated PF-derived MCP-1 by dexamethasone and prostaglandin E2. Dexamethasone 108-121 C-C motif chemokine ligand 2 Homo sapiens 99-104 8424834-3 1993 METHODS: Synthesis and secretion of MCP-1 was determined by immunoprecipitation following metabolic labeling of MCP-1 with 35S-cysteine. 35s-cysteine 123-135 C-C motif chemokine ligand 2 Homo sapiens 36-41 8424834-3 1993 METHODS: Synthesis and secretion of MCP-1 was determined by immunoprecipitation following metabolic labeling of MCP-1 with 35S-cysteine. 35s-cysteine 123-135 C-C motif chemokine ligand 2 Homo sapiens 112-117 8424834-7 1993 Use of cycloheximide and actinomycin D confirmed that TNF alpha was inducing MCP-1 expression at both the transcriptional and translational levels. Cycloheximide 7-20 C-C motif chemokine ligand 2 Homo sapiens 77-82 8424834-7 1993 Use of cycloheximide and actinomycin D confirmed that TNF alpha was inducing MCP-1 expression at both the transcriptional and translational levels. Dactinomycin 25-38 C-C motif chemokine ligand 2 Homo sapiens 77-82 10005561-0 1993 Magnetic phase transitions in CocMg1-cCl2 and stage-2 CocMg1-cCl2 graphite intercalation compounds. Graphite 66-74 C-C motif chemokine ligand 2 Homo sapiens 61-65 1443157-7 1992 Furthermore, we showed the dose- and time-dependent suppression of IL-1 beta-stimulated PF-derived MCP-1 by dexamethasone and prostaglandin E2. Dinoprostone 126-142 C-C motif chemokine ligand 2 Homo sapiens 99-104 1382479-0 1992 Interleukin-8 and RANTES inhibit basophil histamine release induced with monocyte chemotactic and activating factor/monocyte chemoattractant peptide-1 and histamine releasing factor. Histamine 42-51 C-C motif chemokine ligand 2 Homo sapiens 73-115 1382479-1 1992 The objective of this study was to investigate the effect of interleukin-8 (IL-8) and RANTES on basophil histamine release induced with monocyte chemoattractant peptide-1 (MCP-1) and crude histamine releasing factor (HRF). Histamine 105-114 C-C motif chemokine ligand 2 Homo sapiens 136-170 1382479-1 1992 The objective of this study was to investigate the effect of interleukin-8 (IL-8) and RANTES on basophil histamine release induced with monocyte chemoattractant peptide-1 (MCP-1) and crude histamine releasing factor (HRF). Histamine 105-114 C-C motif chemokine ligand 2 Homo sapiens 172-177 1624809-4 1992 Expression of the MCP-1 gene is inducible by activators of the protein kinase A (cAMP) and C (PMA) signal transduction pathways and is differentially regulated by the steroids dexamethasone and retinoic acid. Steroids 167-175 C-C motif chemokine ligand 2 Homo sapiens 18-23 1522232-12 1992 These results suggest that synovial production of MCP-1 may play an important role in the recruitment of mononuclear phagocytes during inflammation associated with RA and that synovial tissue macrophages are the dominant source of this cytokine. Radium 164-166 C-C motif chemokine ligand 2 Homo sapiens 50-55 10004309-0 1992 Effect of XY spin anisotropy on the critical temperature in stage-2 CocNi1-cCl2-graphite intercalation compounds. Graphite 80-88 C-C motif chemokine ligand 2 Homo sapiens 75-79 1365641-11 1992 Dexamethasone blunted the induction of MCP-1 gene expression by IL-1 and by activators of protein kinase A as well as protein kinase C signal transduction pathways. Dexamethasone 0-13 C-C motif chemokine ligand 2 Homo sapiens 39-44 1365641-12 1992 In contrast, retinoic acid strongly increased phorbol myristate acetate-induced MCP-1 expression and potentiated the effects of IL-1 and LPS. Tretinoin 13-26 C-C motif chemokine ligand 2 Homo sapiens 80-85 1365641-12 1992 In contrast, retinoic acid strongly increased phorbol myristate acetate-induced MCP-1 expression and potentiated the effects of IL-1 and LPS. Tetradecanoylphorbol Acetate 46-71 C-C motif chemokine ligand 2 Homo sapiens 80-85 1624809-4 1992 Expression of the MCP-1 gene is inducible by activators of the protein kinase A (cAMP) and C (PMA) signal transduction pathways and is differentially regulated by the steroids dexamethasone and retinoic acid. Cyclic AMP 81-85 C-C motif chemokine ligand 2 Homo sapiens 18-23 1378073-4 1992 In this manuscript, we show that it is capable of inducing histamine release from human basophils at concentrations as low as 10(-10) M and compare its activity with that of monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 (MCAF/MCP-1), another intercrine/chemokine. Histamine 59-68 C-C motif chemokine ligand 2 Homo sapiens 253-257 1378073-4 1992 In this manuscript, we show that it is capable of inducing histamine release from human basophils at concentrations as low as 10(-10) M and compare its activity with that of monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 (MCAF/MCP-1), another intercrine/chemokine. Histamine 59-68 C-C motif chemokine ligand 2 Homo sapiens 258-263 1378073-7 1992 The percent histamine release by RANTES in atopic vs nonatopics was 30.3 +/- 6.7 and 16.5 +/- 2.4, respectively (p less than 0.05), and histamine release by RANTES correlated significantly with histamine release by MCAF (r = 0.69; p less than 0.001) but not with histamine release by anti-IgE (r = 0.29; p greater than 0.05). Histamine 136-145 C-C motif chemokine ligand 2 Homo sapiens 215-219 1378073-7 1992 The percent histamine release by RANTES in atopic vs nonatopics was 30.3 +/- 6.7 and 16.5 +/- 2.4, respectively (p less than 0.05), and histamine release by RANTES correlated significantly with histamine release by MCAF (r = 0.69; p less than 0.001) but not with histamine release by anti-IgE (r = 0.29; p greater than 0.05). Histamine 136-145 C-C motif chemokine ligand 2 Homo sapiens 215-219 1378073-7 1992 The percent histamine release by RANTES in atopic vs nonatopics was 30.3 +/- 6.7 and 16.5 +/- 2.4, respectively (p less than 0.05), and histamine release by RANTES correlated significantly with histamine release by MCAF (r = 0.69; p less than 0.001) but not with histamine release by anti-IgE (r = 0.29; p greater than 0.05). Histamine 136-145 C-C motif chemokine ligand 2 Homo sapiens 215-219 1378073-8 1992 Histamine release by RANTES and MCAF/MCP-1 was extremely rapid, reaching a maximum within 1 min. Histamine 0-9 C-C motif chemokine ligand 2 Homo sapiens 32-36 1378073-8 1992 Histamine release by RANTES and MCAF/MCP-1 was extremely rapid, reaching a maximum within 1 min. Histamine 0-9 C-C motif chemokine ligand 2 Homo sapiens 37-42 1624809-4 1992 Expression of the MCP-1 gene is inducible by activators of the protein kinase A (cAMP) and C (PMA) signal transduction pathways and is differentially regulated by the steroids dexamethasone and retinoic acid. Dexamethasone 176-189 C-C motif chemokine ligand 2 Homo sapiens 18-23 1624809-4 1992 Expression of the MCP-1 gene is inducible by activators of the protein kinase A (cAMP) and C (PMA) signal transduction pathways and is differentially regulated by the steroids dexamethasone and retinoic acid. Tretinoin 194-207 C-C motif chemokine ligand 2 Homo sapiens 18-23 1569397-4 1992 MCP-1 causes a rise in the cytosolic free calcium level in basophils and monocytes, but not in other blood leukocyte types, and triggers basophil degranulation at low concentrations (ED50 = 3-10 nM). Calcium 42-49 C-C motif chemokine ligand 2 Homo sapiens 0-5 1577716-4 1992 Edman degradation and mass spectrometry provided evidence that these protein-bound heme adducts were addition products in which heme-CCL2 or heme-CCl3 were bound to cysteine residue 93 of the beta-chain of hemoglobin. Cysteine 165-173 C-C motif chemokine ligand 2 Homo sapiens 133-137 1577716-2 1992 Recent studies have shown that a protein-bound heme adduct formed from the reaction of BrCCl3 with myoglobin was due to bonding of the proximal histidine residue through the ring I vinyl of a heme-CCl2 moiety. Heme 47-51 C-C motif chemokine ligand 2 Homo sapiens 197-201 1577716-2 1992 Recent studies have shown that a protein-bound heme adduct formed from the reaction of BrCCl3 with myoglobin was due to bonding of the proximal histidine residue through the ring I vinyl of a heme-CCl2 moiety. Histidine 144-153 C-C motif chemokine ligand 2 Homo sapiens 197-201 1577716-2 1992 Recent studies have shown that a protein-bound heme adduct formed from the reaction of BrCCl3 with myoglobin was due to bonding of the proximal histidine residue through the ring I vinyl of a heme-CCl2 moiety. Heme 192-196 C-C motif chemokine ligand 2 Homo sapiens 197-201 1577716-4 1992 Edman degradation and mass spectrometry provided evidence that these protein-bound heme adducts were addition products in which heme-CCL2 or heme-CCl3 were bound to cysteine residue 93 of the beta-chain of hemoglobin. Heme 83-87 C-C motif chemokine ligand 2 Homo sapiens 133-137 1577716-4 1992 Edman degradation and mass spectrometry provided evidence that these protein-bound heme adducts were addition products in which heme-CCL2 or heme-CCl3 were bound to cysteine residue 93 of the beta-chain of hemoglobin. Heme 128-132 C-C motif chemokine ligand 2 Homo sapiens 133-137 1577716-4 1992 Edman degradation and mass spectrometry provided evidence that these protein-bound heme adducts were addition products in which heme-CCL2 or heme-CCl3 were bound to cysteine residue 93 of the beta-chain of hemoglobin. Heme 128-132 C-C motif chemokine ligand 2 Homo sapiens 133-137 1569397-6 1992 Furthermore, MCP-1 promotes the formation of leukotriene C4 by basophils pretreated with interleukin 3 (IL-3), IL-5, or granulocyte/macrophage colony-stimulating factor. Leukotriene C4 45-59 C-C motif chemokine ligand 2 Homo sapiens 13-18 1371775-2 1992 In our pursuit of cytokines affecting basophil function, we studied the effect of MCAF on histamine secretion from basophils. Histamine 90-99 C-C motif chemokine ligand 2 Homo sapiens 82-86 1371775-4 1992 MCAF caused dose-dependent release of histamine at concentrations of 10(-8) and 10(-7) M, and the mean release was 31.25 +/- 2.9% at the highest concentration. Histamine 38-47 C-C motif chemokine ligand 2 Homo sapiens 0-4 1371775-6 1992 All 20 subjects responded to MCAF with significant histamine release. Histamine 51-60 C-C motif chemokine ligand 2 Homo sapiens 29-33 1371775-8 1992 The histamine release was significantly correlated between MCAF and HRF (P less than 0.01), but not between MCAF and anti-IgE (P greater than 0.05). Histamine 4-13 C-C motif chemokine ligand 2 Homo sapiens 59-63 1371775-9 1992 The histamine release by MCAF was complete within the first 3 min. Histamine 4-13 C-C motif chemokine ligand 2 Homo sapiens 25-29 1371775-10 1992 MCAF-induced degranulation was a calcium-dependent process. Calcium 33-40 C-C motif chemokine ligand 2 Homo sapiens 0-4 1370686-1 1992 Recombinant monocyte chemotactic-activating factor (MCAF) has been shown to induce histamine release from human basophils with a dose response between 10(-9) and 10(-6) M. The peak of activity was reached at 10(-7) M. Histamine release by MCAF was rapid with an initial rate comparable with histamine release by an optimal dose of anti-IgE. Histamine 83-92 C-C motif chemokine ligand 2 Homo sapiens 12-50 1370686-1 1992 Recombinant monocyte chemotactic-activating factor (MCAF) has been shown to induce histamine release from human basophils with a dose response between 10(-9) and 10(-6) M. The peak of activity was reached at 10(-7) M. Histamine release by MCAF was rapid with an initial rate comparable with histamine release by an optimal dose of anti-IgE. Histamine 83-92 C-C motif chemokine ligand 2 Homo sapiens 52-56 1370686-1 1992 Recombinant monocyte chemotactic-activating factor (MCAF) has been shown to induce histamine release from human basophils with a dose response between 10(-9) and 10(-6) M. The peak of activity was reached at 10(-7) M. Histamine release by MCAF was rapid with an initial rate comparable with histamine release by an optimal dose of anti-IgE. Histamine 218-227 C-C motif chemokine ligand 2 Homo sapiens 12-50 1370686-1 1992 Recombinant monocyte chemotactic-activating factor (MCAF) has been shown to induce histamine release from human basophils with a dose response between 10(-9) and 10(-6) M. The peak of activity was reached at 10(-7) M. Histamine release by MCAF was rapid with an initial rate comparable with histamine release by an optimal dose of anti-IgE. Histamine 218-227 C-C motif chemokine ligand 2 Homo sapiens 52-56 1370686-1 1992 Recombinant monocyte chemotactic-activating factor (MCAF) has been shown to induce histamine release from human basophils with a dose response between 10(-9) and 10(-6) M. The peak of activity was reached at 10(-7) M. Histamine release by MCAF was rapid with an initial rate comparable with histamine release by an optimal dose of anti-IgE. Histamine 291-300 C-C motif chemokine ligand 2 Homo sapiens 12-50 1370686-1 1992 Recombinant monocyte chemotactic-activating factor (MCAF) has been shown to induce histamine release from human basophils with a dose response between 10(-9) and 10(-6) M. The peak of activity was reached at 10(-7) M. Histamine release by MCAF was rapid with an initial rate comparable with histamine release by an optimal dose of anti-IgE. Histamine 291-300 C-C motif chemokine ligand 2 Homo sapiens 52-56 1370686-2 1992 MCAF led to peak histamine release within 1 min. Histamine 17-26 C-C motif chemokine ligand 2 Homo sapiens 0-4 1370686-4 1992 The percentage histamine release by MCAF was, however, less than that seen with anti-IgE or FMLP, but this was attributable to a lesser percent release in nonatopic subjects; atopic subjects responded similarly to all three agonists. Histamine 15-24 C-C motif chemokine ligand 2 Homo sapiens 36-40 1370686-6 1992 At a suboptimal concentration (2.5 x 10(-9) M), MCAF was unable to prime the basophil to histamine release by other secretagogues. Histamine 89-98 C-C motif chemokine ligand 2 Homo sapiens 48-52 1872855-0 1991 Initial characterization of the carbohydrate structure of MCP-1. Carbohydrates 32-44 C-C motif chemokine ligand 2 Homo sapiens 58-63 1868242-0 1991 Recombinant human MCP-1/JE induces chemotaxis, calcium flux, and the respiratory burst in human monocytes. Calcium 47-54 C-C motif chemokine ligand 2 Homo sapiens 18-26 1868242-3 1991 We purified recombinant human MCP-1/JE (hMCP-1/JE) produced in COS cells and demonstrated that it is chemotactic for human monocytes with a specific activity similar to natural MCP-1. carbonyl sulfide 63-66 C-C motif chemokine ligand 2 Homo sapiens 40-49 1868242-3 1991 We purified recombinant human MCP-1/JE (hMCP-1/JE) produced in COS cells and demonstrated that it is chemotactic for human monocytes with a specific activity similar to natural MCP-1. carbonyl sulfide 63-66 C-C motif chemokine ligand 2 Homo sapiens 30-35 1868242-4 1991 In addition, pure recombinant hMCP-1/JE stimulates monocytes, inducing an increase in cytosolic free calcium and the respiratory burst, but is completely inactive on human neutrophils. Calcium 101-108 C-C motif chemokine ligand 2 Homo sapiens 30-39 1872855-4 1991 The results indicate that the disaccharide galactose-beta 1-3D-N-acetyl galactosamine is present on the 13 kD MCP-1 isoform but not the 9 kD isoform. Disaccharides 30-42 C-C motif chemokine ligand 2 Homo sapiens 110-115 1993694-5 1991 We have found that the ring I vinyl group of the prosthetic heme was altered by the addition of a histidine imidazole nitrogen to the alpha-carbon and a CCl2 moiety to the beta-carbon. Heme 60-64 C-C motif chemokine ligand 2 Homo sapiens 153-157 2018524-5 1991 Studies with synthetic peptides constructed according to the MCP-1 amino acid sequence indicate that a synthetic peptide, MCP-1[13-35], stimulates monocyte migration and competes with native MCP-1 for binding sites. Peptides 23-30 C-C motif chemokine ligand 2 Homo sapiens 61-66 2018524-5 1991 Studies with synthetic peptides constructed according to the MCP-1 amino acid sequence indicate that a synthetic peptide, MCP-1[13-35], stimulates monocyte migration and competes with native MCP-1 for binding sites. Peptides 23-30 C-C motif chemokine ligand 2 Homo sapiens 122-127 2018524-5 1991 Studies with synthetic peptides constructed according to the MCP-1 amino acid sequence indicate that a synthetic peptide, MCP-1[13-35], stimulates monocyte migration and competes with native MCP-1 for binding sites. Peptides 23-30 C-C motif chemokine ligand 2 Homo sapiens 122-127 1937585-3 1991 The buffy-coat cellular expression of neutrophil chemotactic/activating factor/interleukin 8 (IL-8) and monocyte chemotactic/activating protein (MCP-1) mRNA were time and dose-dependent in response to either lipopolysaccharide or zymosan stimulation. Zymosan 230-237 C-C motif chemokine ligand 2 Homo sapiens 145-150 9998077-0 1991 Structural and magnetic properties of stage-2 CocMn1-cCl2-graphite intercalation compounds. Graphite 58-66 C-C motif chemokine ligand 2 Homo sapiens 53-57 1991962-3 1991 Over a wide range of concentrations (10(-5) to 10(-8) M), DXS inhibited the production of MCAF at the mRNA and protein level in a human fibrosarcoma cell line, which was stimulated with either IL-1 or TNF-alpha. Dexamethasone 58-61 C-C motif chemokine ligand 2 Homo sapiens 90-94 1991962-6 1991 In addition, a nuclear run-off analysis revealed that DXS also inhibited the transcription of IL-1- or TNF-activated MCAF genes. Dexamethasone 54-57 C-C motif chemokine ligand 2 Homo sapiens 117-121 1991962-7 1991 Therefore, both the destabilization of MCAF mRNA and the inhibition of transcription of the gene contribute to the decrease in the MCAF mRNA steady state level by DXS. Dexamethasone 163-166 C-C motif chemokine ligand 2 Homo sapiens 39-43 1991962-7 1991 Therefore, both the destabilization of MCAF mRNA and the inhibition of transcription of the gene contribute to the decrease in the MCAF mRNA steady state level by DXS. Dexamethasone 163-166 C-C motif chemokine ligand 2 Homo sapiens 131-135 1993694-5 1991 We have found that the ring I vinyl group of the prosthetic heme was altered by the addition of a histidine imidazole nitrogen to the alpha-carbon and a CCl2 moiety to the beta-carbon. Carbon 177-183 C-C motif chemokine ligand 2 Homo sapiens 153-157 1755379-1 1991 In this communication, we have asked if MCP-1 is the mediator of cellular infiltration in DCH, outlining the criteria in Table 3. dicyclohexylamine 90-93 C-C motif chemokine ligand 2 Homo sapiens 40-45 2211704-12 1990 Differences in carbohydrate processing account for the heterogeneity in MCP-1/SMC-CF-like proteins produced by different cell types. Carbohydrates 15-27 C-C motif chemokine ligand 2 Homo sapiens 72-77 2211704-12 1990 Differences in carbohydrate processing account for the heterogeneity in MCP-1/SMC-CF-like proteins produced by different cell types. Carbohydrates 15-27 C-C motif chemokine ligand 2 Homo sapiens 78-84 2162890-7 1990 Detection by flow cytometry of bound biotinylated MCP-1 with avidin-FITC confirmed results obtained with 125I-MCP-1. avidin-fitc 61-72 C-C motif chemokine ligand 2 Homo sapiens 50-55 2161898-2 1990 The purified MCAF showed microheterogeneity yielding two bands on SDS-PAGE analysis. Sodium Dodecyl Sulfate 66-69 C-C motif chemokine ligand 2 Homo sapiens 13-17 1695010-7 1990 Incorporation of [35S]methionine into the immunoprecipitated proteins paralleled the monocyte chemotactic activity found in the medium of MM-LDL stimulated EC and the levels of MCP-1 mRNA found in the EC. [35s]methionine 17-32 C-C motif chemokine ligand 2 Homo sapiens 177-182 2355004-4 1990 It was found that the prosthetic heme was modified by a CCl2 moiety derived from BrCCl3 and was covalently bound to histidine residue 93, the normal proximal ligand to the heme-iron. Heme 33-37 C-C motif chemokine ligand 2 Homo sapiens 56-60 2355004-4 1990 It was found that the prosthetic heme was modified by a CCl2 moiety derived from BrCCl3 and was covalently bound to histidine residue 93, the normal proximal ligand to the heme-iron. Bromotrichloromethane 81-87 C-C motif chemokine ligand 2 Homo sapiens 56-60 2355004-4 1990 It was found that the prosthetic heme was modified by a CCl2 moiety derived from BrCCl3 and was covalently bound to histidine residue 93, the normal proximal ligand to the heme-iron. Histidine 116-125 C-C motif chemokine ligand 2 Homo sapiens 56-60 2355004-4 1990 It was found that the prosthetic heme was modified by a CCl2 moiety derived from BrCCl3 and was covalently bound to histidine residue 93, the normal proximal ligand to the heme-iron. Heme 172-176 C-C motif chemokine ligand 2 Homo sapiens 56-60 2355004-4 1990 It was found that the prosthetic heme was modified by a CCl2 moiety derived from BrCCl3 and was covalently bound to histidine residue 93, the normal proximal ligand to the heme-iron. Iron 177-181 C-C motif chemokine ligand 2 Homo sapiens 56-60 2161898-3 1990 Fibrosarcoma-derived MCAF specifically competed with THP-1 (a human monocytic cell line)-derived 125I-labeled MCAF in binding to human PBMC, whereas a similar basic heparin-binding leukocyte chemoattractant, IL-8, did not. Iodine-125 97-101 C-C motif chemokine ligand 2 Homo sapiens 21-25 2161898-3 1990 Fibrosarcoma-derived MCAF specifically competed with THP-1 (a human monocytic cell line)-derived 125I-labeled MCAF in binding to human PBMC, whereas a similar basic heparin-binding leukocyte chemoattractant, IL-8, did not. Iodine-125 97-101 C-C motif chemokine ligand 2 Homo sapiens 110-114 2161898-4 1990 The purified MCAF stimulated superoxide anion and N-acetyl beta-D glucosaminidase-releasing activity in human monocytes, as well as monocyte cytostatic augmenting activity against tumor cells and chemotactic activity for monocytes. Superoxides 29-45 C-C motif chemokine ligand 2 Homo sapiens 13-17 33588264-12 2021 Further studies in 16HBE showed that AVE0991 pre-treatment inhibited LPS-induced or anisomycin-induced CCL2 increase and THP-1 macrophages migration via JNK pathways. Anisomycin 84-94 C-C motif chemokine ligand 2 Homo sapiens 103-107 33775710-6 2021 miR-196a increased CCL2 secretion in fibroblasts, and that was suppressed by ANXA1. mir-196a 0-8 C-C motif chemokine ligand 2 Homo sapiens 19-23 33971977-6 2021 RESULTS: Pre-incubating WI-38 cells with low and medium concentrations GA protected LPS-induced cell death, apoptosis and inflammatory protein productions of IL-6 and MCP-1. gambogic acid 71-73 C-C motif chemokine ligand 2 Homo sapiens 167-172 33945102-9 2021 Imipramine, desipramine, and fluoxetine suppress the production of IL-1beta, CCL2, as well as the expression of ICAM-1. Imipramine 0-10 C-C motif chemokine ligand 2 Homo sapiens 77-81 33945102-9 2021 Imipramine, desipramine, and fluoxetine suppress the production of IL-1beta, CCL2, as well as the expression of ICAM-1. Desipramine 12-23 C-C motif chemokine ligand 2 Homo sapiens 77-81 33945102-9 2021 Imipramine, desipramine, and fluoxetine suppress the production of IL-1beta, CCL2, as well as the expression of ICAM-1. Fluoxetine 29-39 C-C motif chemokine ligand 2 Homo sapiens 77-81 33945178-3 2021 Herein, CCL2 and CCL5 are screened as two major chemokines responsible for attracting TAM infiltration and inducing their polarization toward cancer-promoting M2-phenotype. tam 86-89 C-C motif chemokine ligand 2 Homo sapiens 8-12 33782965-2 2021 CCL2 is a member of the CC chemokine superfamily, which binds to its receptor, C-C motif chemokine receptor-2 (CCR2), for the induction of chemotactic activity and an increase of calcium influx. Calcium 179-186 C-C motif chemokine ligand 2 Homo sapiens 0-4 33822421-6 2021 Moreover, HUVECs pretreatment with silibinin reduced TNF-alpha-induced gene expression of the proinflammatory genes IL-6 and MCP-1, as well as of PAI-1, a critical factor in coagulopathy and thrombosis, and of ET-1, a peptide involved in hemostatic vasoconstriction. Silybin 35-44 C-C motif chemokine ligand 2 Homo sapiens 125-130 34781065-8 2022 TCDD-treated PBMCs increased the migration capacity of MenSCs and up-regulated MCP-1 and IL-6 levels in the PBMCs/MenSCs co-culture (P <= 0.01-0.0001). Polychlorinated Dibenzodioxins 0-4 C-C motif chemokine ligand 2 Homo sapiens 79-84 33801190-12 2021 Partial correlation (controlling for age, gender and Body Mass Index (BMI)) revealed a significant direct relation between MCP-1 and norepinephrine (r = 0.47, p = 0.03) and MCP-1 and epinephrine (r = 0.46, p = 0.04) in patients with -D+CAD at rest. Norepinephrine 133-147 C-C motif chemokine ligand 2 Homo sapiens 123-128 33801190-12 2021 Partial correlation (controlling for age, gender and Body Mass Index (BMI)) revealed a significant direct relation between MCP-1 and norepinephrine (r = 0.47, p = 0.03) and MCP-1 and epinephrine (r = 0.46, p = 0.04) in patients with -D+CAD at rest. Epinephrine 136-147 C-C motif chemokine ligand 2 Homo sapiens 123-128 20233899-7 2010 Deletion of STAT2 decreased azoxymethane/dextran sodium sulfate-induced expression and release of proinflammatory mediators, such as interleukin-6 and CCL2, and decreased interleukin-6 release from skin carcinoma cells, which then decreased STAT3 activation. dextran sodium sulfate 41-63 C-C motif chemokine ligand 2 Homo sapiens 151-155 34515610-4 2022 CCL2 expression and Treg abundance were increased in tumor tissues after surgical trauma, and CCL2 expression was positively associated with Treg abundance. treg 141-145 C-C motif chemokine ligand 2 Homo sapiens 94-98 34515610-5 2022 These results demonstrated that surgical trauma contributes to lung cancer progression by increasing CCL2 expression, thus promoting Treg recruitment. treg 133-137 C-C motif chemokine ligand 2 Homo sapiens 101-105 34427852-5 2022 Our results showed that GA significantly attenuated LPS-induced ALI and decreased the production of inflammatory factors, including IL-1beta, MCP-1, COX2, HMGB1, and adhesion molecules, such as E-selectin, VCAM-1, and modulated expression of angiotensin-converting enzyme 2 (ACE2). Glycyrrhizic Acid 24-26 C-C motif chemokine ligand 2 Homo sapiens 142-147 33778274-8 2021 Results: First, the reduced mitochondrial membrane potential (DeltaPsim) and secretion of proinflammatory factors (IL-1beta, IL-8, and MCP-1) induced by TNF-alpha were significantly reversed by treatment with Feprazone. Feprazone 209-218 C-C motif chemokine ligand 2 Homo sapiens 135-140 33799833-6 2021 Chronic 2S-hesperidin supplementation increased endogenous antioxidant capacity ( SOD) after maximal effort and decreased oxidative stress ( AUC-GSSG) during the rectangular test, decreasing inflammation ( MCP1) after the acute recovery phase. Hesperidin 8-21 C-C motif chemokine ligand 2 Homo sapiens 206-210 27667548-5 2016 Furthermore, baicalein blocked the TNF-alpha-induced expression of NF-kappaB target genes involved in anti-apoptosis (cIAP-1, cIAP-2, FLIP and BCL-2), proliferation (COX-2, cyclin D1 and c-Myc), invasion (MMP-9), angiogenesis (VEGF) and major inflammatory cytokines (IL-8 and MCP1). baicalein 13-22 C-C motif chemokine ligand 2 Homo sapiens 276-280 20233899-7 2010 Deletion of STAT2 decreased azoxymethane/dextran sodium sulfate-induced expression and release of proinflammatory mediators, such as interleukin-6 and CCL2, and decreased interleukin-6 release from skin carcinoma cells, which then decreased STAT3 activation. Azoxymethane 28-40 C-C motif chemokine ligand 2 Homo sapiens 151-155 34808298-10 2022 ZJP could dose-dependently decrease the serum IL-6, MCP-1, PGE2, TNF-alpha, and VEGF level and significantly improved gastric tissue inflammatory lesions. zjp 0-3 C-C motif chemokine ligand 2 Homo sapiens 52-57 34613549-9 2022 We found that suppressing phosphorylation of the JNK1/2 and p38 MAPK signaling pathways inhibited IL-6, MCP-1, and sICAM-1 secretion, implicating these pathways and NF-kappaB suppression in the effects of oleuropein. oleuropein 205-215 C-C motif chemokine ligand 2 Homo sapiens 104-109 34738645-7 2022 Highest levels of CCL2 and CXCL8 were seen in HCVINB- , whereas CXCL9 and CXCL10 in HCVINB+ . hcvinb 46-52 C-C motif chemokine ligand 2 Homo sapiens 18-22 34547432-11 2022 Dexamethasone shows dual treatment effects on synovium (pro-resolving macrophage upregulation, protease downregulation) and cartilage (pro-inflammatory, catabolic, and anabolic downregulation), and decreases soluble CCL2 levels in co-culture, thereby validating OA-EXM utility. Dexamethasone 0-13 C-C motif chemokine ligand 2 Homo sapiens 216-220 34673277-7 2022 In vitro study revealed that TMAO directly induced primary peritoneal mesothelial cell necrosis, together with increased production of pro-inflammatory cytokines including CCL2, TNF-alpha, IL-6 and IL-1beta. trimethyloxamine 29-33 C-C motif chemokine ligand 2 Homo sapiens 172-176 34673277-8 2022 In addition, TMAO significantly increased TNF-alpha-induced P-selectin production in mesothelial cells, as well as high glucose-induced TNF-alpha and CCL2 expression in endothelial cells. trimethyloxamine 13-17 C-C motif chemokine ligand 2 Homo sapiens 150-154 34673277-8 2022 In addition, TMAO significantly increased TNF-alpha-induced P-selectin production in mesothelial cells, as well as high glucose-induced TNF-alpha and CCL2 expression in endothelial cells. Glucose 120-127 C-C motif chemokine ligand 2 Homo sapiens 150-154 34850458-6 2022 The shifting and intensity enhancement of the CCl2 band manifests the back-donation and conjugation effect, which are the result of the presence of nitrogen atom adjoining the dichloromethyl groups and the oxygen in the sulfur dioxide group attached among the amino group and the chlorophenyl ring, respectively, which enhances bioactivity. Nitrogen 148-156 C-C motif chemokine ligand 2 Homo sapiens 46-50 34850458-6 2022 The shifting and intensity enhancement of the CCl2 band manifests the back-donation and conjugation effect, which are the result of the presence of nitrogen atom adjoining the dichloromethyl groups and the oxygen in the sulfur dioxide group attached among the amino group and the chlorophenyl ring, respectively, which enhances bioactivity. Oxygen 206-212 C-C motif chemokine ligand 2 Homo sapiens 46-50 34850458-6 2022 The shifting and intensity enhancement of the CCl2 band manifests the back-donation and conjugation effect, which are the result of the presence of nitrogen atom adjoining the dichloromethyl groups and the oxygen in the sulfur dioxide group attached among the amino group and the chlorophenyl ring, respectively, which enhances bioactivity. Sulfur Dioxide 220-234 C-C motif chemokine ligand 2 Homo sapiens 46-50 34881566-9 2022 Furthermore, cell experiments demonstrated that such glyco-nanostructures can further facilitate the functions of a model drug of the pyridone agent to reduce the expression of monocyte chemotactic protein-1 (MCP-1) and interleukin -1beta (IL-1beta) in the primary peritoneal macrophages via encapsulating drugs. Pyridones 134-142 C-C motif chemokine ligand 2 Homo sapiens 177-207 34881566-9 2022 Furthermore, cell experiments demonstrated that such glyco-nanostructures can further facilitate the functions of a model drug of the pyridone agent to reduce the expression of monocyte chemotactic protein-1 (MCP-1) and interleukin -1beta (IL-1beta) in the primary peritoneal macrophages via encapsulating drugs. Pyridones 134-142 C-C motif chemokine ligand 2 Homo sapiens 209-214 34974176-8 2022 Compared with that of the CCL2 loaded ADSC-HUVECs cell sheet assembled DAT system, adding the silica expander capsule resulted in significantly increased construct stability, new vessel intensity, a greater number of Oil Red O-positive lipid droplets, more enhanced tissue remodeling, and upregulated peroxisome proliferator-activated receptor gamma (PPARgamma) & leptin expression. Silicon Dioxide 94-100 C-C motif chemokine ligand 2 Homo sapiens 26-30 34959604-6 2021 The MCP-1, ICAM-1, and VCAM-1 levels in human umbilical vein endothelial cells were upregulated following treatment with rWRS, and TAK242 suppressed these effects. ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 131-137 C-C motif chemokine ligand 2 Homo sapiens 4-9 34930349-1 2021 BACKGROUND: To investigate the role of adenosine monophosphate (AMP)-activated protein kinase (AMPK) on the production of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, prostaglandin E2 and F2alpha induced by IL-1beta in endometrial stromal cells (ESCs) following treatment with 5-aminoimidazole-4- carboxamide ribonucleoside (AICAR). Adenosine 39-48 C-C motif chemokine ligand 2 Homo sapiens 142-182 34930349-1 2021 BACKGROUND: To investigate the role of adenosine monophosphate (AMP)-activated protein kinase (AMPK) on the production of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, prostaglandin E2 and F2alpha induced by IL-1beta in endometrial stromal cells (ESCs) following treatment with 5-aminoimidazole-4- carboxamide ribonucleoside (AICAR). Adenosine Monophosphate 64-67 C-C motif chemokine ligand 2 Homo sapiens 142-182 34930349-1 2021 BACKGROUND: To investigate the role of adenosine monophosphate (AMP)-activated protein kinase (AMPK) on the production of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, prostaglandin E2 and F2alpha induced by IL-1beta in endometrial stromal cells (ESCs) following treatment with 5-aminoimidazole-4- carboxamide ribonucleoside (AICAR). 5-aminoimidazole-4- carboxamide ribonucleoside 294-340 C-C motif chemokine ligand 2 Homo sapiens 142-182 34930349-1 2021 BACKGROUND: To investigate the role of adenosine monophosphate (AMP)-activated protein kinase (AMPK) on the production of interleukin (IL)-8, monocyte chemoattractant protein (MCP)-1, prostaglandin E2 and F2alpha induced by IL-1beta in endometrial stromal cells (ESCs) following treatment with 5-aminoimidazole-4- carboxamide ribonucleoside (AICAR). acadesine 342-347 C-C motif chemokine ligand 2 Homo sapiens 142-182 34930349-3 2021 We examined the effects of IL-1beta, IL-1 ra and AICAR on the production of IL-8, MCP-1, PGE2 and PGF2alpha in human ESCs. acadesine 49-54 C-C motif chemokine ligand 2 Homo sapiens 82-87 34920714-0 2021 Nitro-fatty acids decrease type I interferons and monocyte chemoattractant protein 1 in ex vivo models of inflammatory arthritis. nitro-fatty acids 0-17 C-C motif chemokine ligand 2 Homo sapiens 50-84 34857006-12 2021 injection of CCL2 completely blocked DAMGO-induced thermal hypoalgesia and intraperitoneal pre-treatment with minocycline prevented the CCL2 effect. Minocycline 110-121 C-C motif chemokine ligand 2 Homo sapiens 136-140 34944529-8 2021 VEGF, MCP-1 and Il-12 levels in PBMCs supernatants from the glucose-containing medium were higher than those from the standard medium in each of the diabetic groups. Glucose 60-67 C-C motif chemokine ligand 2 Homo sapiens 6-11 34877932-3 2021 Here, we report that TTP was upregulated in acute liver failure (ALF), resulting in decreased mRNA stabilities of CCL2 and CCL5 through promotion of N6-methyladenosine (m6A) mRNA methylation. N-methyladenosine 149-167 C-C motif chemokine ligand 2 Homo sapiens 114-118 34893345-3 2022 We investigated age-changes in calcium (Ca2+) response to CCL2 and LPS in human monocytes. Calcium 31-38 C-C motif chemokine ligand 2 Homo sapiens 58-62 34938289-10 2021 Among critically ill patients, MCP-1 predicted the duration of mechanical ventilation, highest norepinephrine dose administered, and length of intensive care stay. Norepinephrine 95-109 C-C motif chemokine ligand 2 Homo sapiens 31-36 34871429-9 2022 RESULTS: DHA concentration in RBC membranes was inversely associated with IL-6 (beta = -0.0066, P < 0.001); EPA was inversely associated with TNFalpha (beta = -0.4925, P < 0.001); and the NIR was inversely associated with MCP-1 (beta = -0.8345, P < 0.001) and IL-10 (beta = -1.2868, P < 0.001). dehydroacetic acid 9-12 C-C motif chemokine ligand 2 Homo sapiens 222-227 34848446-0 2021 Effect of Diallyl Trisulfide on TNF-alpha-induced CCL2/MCP-1 Release in Genetically Different Triple-negative Breast Cancer Cells. diallyl trisulfide 10-28 C-C motif chemokine ligand 2 Homo sapiens 50-54 34515626-8 2021 In contrast, a high-sucrose diet induced increased number of large-sized lipid droplets, increased CD68+ macrophage- and MCP-1-positive areas, and decreased UCP-1 positive area in the thoracic aortic PVAT (tPVAT). Sucrose 20-27 C-C motif chemokine ligand 2 Homo sapiens 121-126 34515626-9 2021 A high-sucrose diet caused decreased collagen fibre-positive area and increased CD68+ macrophage- and MCP-1-positive areas in the thoracic aorta. Sucrose 7-14 C-C motif chemokine ligand 2 Homo sapiens 102-107 34308659-6 2021 Further, methyl mercury treatment also upregulated the chemotactic cytokine monocyte chemoattractant protein-1 and intercellular adhesion molecule-1. methyl mercury 9-23 C-C motif chemokine ligand 2 Homo sapiens 76-110 34288819-6 2021 Firstly, we found that Anagliptin treatment ameliorated the elevated secretions of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and macrophage chemoattractant protein-1 (MCP-1). anagliptin 23-33 C-C motif chemokine ligand 2 Homo sapiens 150-186 34288819-6 2021 Firstly, we found that Anagliptin treatment ameliorated the elevated secretions of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and macrophage chemoattractant protein-1 (MCP-1). anagliptin 23-33 C-C motif chemokine ligand 2 Homo sapiens 188-193 34668346-11 2021 Res suppressed Cd-induced apoptosis in placenta and JEG-3 cells, and decreased Cd-induced expression of TNF-alpha, IFN-gamma, MCP-1, MIP-2, and KC in placenta. Cadmium 79-81 C-C motif chemokine ligand 2 Homo sapiens 126-131 34705053-4 2021 2-DG treatment showed a more robust impact on impairing the RA M1 MPhi-mediated inflammatory phenotype than IACS-010759 (IACS, complexli), by reversing ERK, AKT and STAT1 signaling, IRF8/3 transcription and CCL2 or CCL5 secretion. Deoxyglucose 0-4 C-C motif chemokine ligand 2 Homo sapiens 207-211 34717170-3 2021 This open-label, prospective, observational study evaluated the effect of valproate and add-on levetiracetam on serum levels of C-C motif ligand 2 (CCL2) and Interleukin-1 beta (IL-1beta) in pediatric patients with epilepsy. Valproic Acid 74-83 C-C motif chemokine ligand 2 Homo sapiens 128-146 34717170-3 2021 This open-label, prospective, observational study evaluated the effect of valproate and add-on levetiracetam on serum levels of C-C motif ligand 2 (CCL2) and Interleukin-1 beta (IL-1beta) in pediatric patients with epilepsy. Valproic Acid 74-83 C-C motif chemokine ligand 2 Homo sapiens 148-152 34717170-3 2021 This open-label, prospective, observational study evaluated the effect of valproate and add-on levetiracetam on serum levels of C-C motif ligand 2 (CCL2) and Interleukin-1 beta (IL-1beta) in pediatric patients with epilepsy. Levetiracetam 95-108 C-C motif chemokine ligand 2 Homo sapiens 128-146 34717170-3 2021 This open-label, prospective, observational study evaluated the effect of valproate and add-on levetiracetam on serum levels of C-C motif ligand 2 (CCL2) and Interleukin-1 beta (IL-1beta) in pediatric patients with epilepsy. Levetiracetam 95-108 C-C motif chemokine ligand 2 Homo sapiens 148-152 34717170-8 2021 RESULTS: The serum CCL2 level decreased significantly (p < .001) from 327.95 +- 59.07 pg/ml to 207.02 +- 41.50 pg/ml in the valproate group and from 420.65 +- 83.72 pg/ml to 250.06 +- 46.05 pg/ml in the add-on levetiracetam group. Valproic Acid 124-133 C-C motif chemokine ligand 2 Homo sapiens 19-23 34717170-8 2021 RESULTS: The serum CCL2 level decreased significantly (p < .001) from 327.95 +- 59.07 pg/ml to 207.02 +- 41.50 pg/ml in the valproate group and from 420.65 +- 83.72 pg/ml to 250.06 +- 46.05 pg/ml in the add-on levetiracetam group. Levetiracetam 210-223 C-C motif chemokine ligand 2 Homo sapiens 19-23 34717170-11 2021 CONCLUSIONS: The results of our study suggest that valproate and levetiracetam led to decrease serum CCL2 levels without any change in serum IL-1beta levels in children with epilepsy. Valproic Acid 51-60 C-C motif chemokine ligand 2 Homo sapiens 101-105 34717170-11 2021 CONCLUSIONS: The results of our study suggest that valproate and levetiracetam led to decrease serum CCL2 levels without any change in serum IL-1beta levels in children with epilepsy. Levetiracetam 65-78 C-C motif chemokine ligand 2 Homo sapiens 101-105 34717170-12 2021 Anti-inflammatory property of valproate and levetiracetam might underlie their antiepileptic effect and CCL2 could be a potential marker of drug efficacy in epilepsy. Valproic Acid 30-39 C-C motif chemokine ligand 2 Homo sapiens 104-108 34719112-4 2021 For the first time, this paper reviews the evidence from in vitro and in vivo experimental models to explore the anti-inflammatory effects of BBR in periodontitis and exhibits that BBR has the high potency to exert anti-inflammatory effects by reducing expression and secretion of pro-inflammatory mediators including TNF-alpha, IL-1beta, IL-17, RANKL, MMP-2, MMP-9 and MCP-1. Berberine 181-184 C-C motif chemokine ligand 2 Homo sapiens 370-375 34525267-9 2021 RESULTS: We found that CCL2 highly increased in PDAC tissues. pdac 48-52 C-C motif chemokine ligand 2 Homo sapiens 23-27 34525267-13 2021 Furthermore, we have found that M-MDSCs impeded T cell proliferation and produced high levels of ROS and Arginase, which can be enhanced by CCL2. Reactive Oxygen Species 97-100 C-C motif chemokine ligand 2 Homo sapiens 140-144 34525267-15 2021 Treatment of aloesin, MAPK signaling inhibitor, relieved the associated immunosuppressive phenotype induced by CCL2. aloesin 13-20 C-C motif chemokine ligand 2 Homo sapiens 111-115 34824203-3 2021 CCL2+ TAMs are related to the immune response and exhibit a high capacity for apoptosis, while CD44+ TAMs are associated with tumor angiogenesis. Tamoxifen 6-10 C-C motif chemokine ligand 2 Homo sapiens 0-4 34861664-8 2022 In our experiments, pinitol reduced the production of ROS and expression of IL-6 and MCP-1 induced by ox-LDL. pinitol 20-27 C-C motif chemokine ligand 2 Homo sapiens 85-90 34879788-4 2021 Generalized estimating equation was used to evaluate the association between exposure to PM2.5 and NO2 and the following serum cytokine levels on the 7 days preceding clinical assessment and serum collection: MCP1, IL-6, IL-8, IL-10, IL-17, IFN-alpha, and TNF-alpha. pm2.5 89-94 C-C motif chemokine ligand 2 Homo sapiens 209-213 34879788-4 2021 Generalized estimating equation was used to evaluate the association between exposure to PM2.5 and NO2 and the following serum cytokine levels on the 7 days preceding clinical assessment and serum collection: MCP1, IL-6, IL-8, IL-10, IL-17, IFN-alpha, and TNF-alpha. Nitrogen Dioxide 99-102 C-C motif chemokine ligand 2 Homo sapiens 209-213 34537380-15 2021 Lastly, in OA hFLS, HU308 treatment inhibited IL-1beta-induced CCL2, MMP1, MMP3, and IL6 expression and further inhibited TNF-alpha-induced CCL2, MMP1, and GMCSF expression, demonstrating human OA-relevant anti-inflammatory effects by targeting CB2. HU 308 20-25 C-C motif chemokine ligand 2 Homo sapiens 63-67 34537380-15 2021 Lastly, in OA hFLS, HU308 treatment inhibited IL-1beta-induced CCL2, MMP1, MMP3, and IL6 expression and further inhibited TNF-alpha-induced CCL2, MMP1, and GMCSF expression, demonstrating human OA-relevant anti-inflammatory effects by targeting CB2. HU 308 20-25 C-C motif chemokine ligand 2 Homo sapiens 140-144 34869768-9 2021 dTAC correlated positively with Deltamonocyte 1 chemotactic protein (CCL-2) and DeltaC-reactive protein (CRP). dodecyltrimethylammonium 0-4 C-C motif chemokine ligand 2 Homo sapiens 69-74 33820486-3 2021 METHODS: We examined the effect of polyinosinic-polycytidylic acid (poly IC), an agonist of TLR3, on MCP-1, CCL5 and interferon (IFN)-beta expression in GECs. Poly I-C 35-66 C-C motif chemokine ligand 2 Homo sapiens 101-106 33820486-3 2021 METHODS: We examined the effect of polyinosinic-polycytidylic acid (poly IC), an agonist of TLR3, on MCP-1, CCL5 and interferon (IFN)-beta expression in GECs. Poly I-C 68-75 C-C motif chemokine ligand 2 Homo sapiens 101-106 33820486-6 2021 RESULTS: Poly IC increased MCP-1 and CCL5 expression in a time- and concentration-dependent manner in GECs. poly 9-13 C-C motif chemokine ligand 2 Homo sapiens 27-32 33820486-7 2021 Pretreating cells with CQ, but not DEX, attenuated poly IC-induced MCP-1 and CCL5 expression; however, HCQ pretreatment attenuated poly IC-induced CCL5, but not MCP-1. Chloroquine 23-25 C-C motif chemokine ligand 2 Homo sapiens 67-72 34912231-10 2021 Besides, MCP-1 levels were significantly decreased in HR-DP and HR-CB groups compared to the HR-C group (p-value <= 0.05). Dipyridamole 57-59 C-C motif chemokine ligand 2 Homo sapiens 9-14 34912231-10 2021 Besides, MCP-1 levels were significantly decreased in HR-DP and HR-CB groups compared to the HR-C group (p-value <= 0.05). (S)-2-((S)-2-Amino-3-(1H-imidazol-4-yl)Propanamido)-5-guanidinopentanoic acid 64-66 C-C motif chemokine ligand 2 Homo sapiens 9-14 34803718-12 2021 JZ-1 administration obviously ameliorates inflammatory responses with reduced T-lymphocytes, T helper cells, macrophages and neutrophils infiltration, and local IL-1beta, IL-6, TNF-alpha and CCL2 levels. jz-1 0-4 C-C motif chemokine ligand 2 Homo sapiens 191-195 34773923-7 2022 Mean predicted percent inhibition of ex vivo lipopolysaccharide (LPS)-induced MCP-1 reached 75% with 40 mg GSK3358699. gsk3358699 107-117 C-C motif chemokine ligand 2 Homo sapiens 78-83 34830366-4 2021 Low concentrations of resveratrol (0.25-2 mum) also significantly attenuated TNF-alpha-stimulated mRNA expressions of MCP-1/CCL2 and ICAM-1, which are vital mediators of EC-monocyte adhesion molecules and cytokines for cardiovascular plaque formation. Resveratrol 22-33 C-C motif chemokine ligand 2 Homo sapiens 118-123 34830366-4 2021 Low concentrations of resveratrol (0.25-2 mum) also significantly attenuated TNF-alpha-stimulated mRNA expressions of MCP-1/CCL2 and ICAM-1, which are vital mediators of EC-monocyte adhesion molecules and cytokines for cardiovascular plaque formation. Resveratrol 22-33 C-C motif chemokine ligand 2 Homo sapiens 124-128 34059950-8 2021 RESULTS: VEGF, MCP-1, IL-8, and IL-6 levels in the aqueous humor of patients with RVO-ME were significantly higher compared with control and were positively correlated with the CRTBT. rvo-me 82-88 C-C motif chemokine ligand 2 Homo sapiens 15-20 34265211-8 2021 Changes in fasting glucose and AUC of OGTT (0-120 min) were positively correlated with changes in MCP-1 and TNF-alpha (p < 0.05). Glucose 19-26 C-C motif chemokine ligand 2 Homo sapiens 98-103 34059950-12 2021 CONCLUSION: VEGF, MCP-1, IL-8, and IL-6 levels were significantly increased in patients with RVO-ME and were positively correlated with ME. rvo-me 93-99 C-C motif chemokine ligand 2 Homo sapiens 18-23 34665696-7 2021 RESULTS: Baricitinib inhibited OSM-induced JAK signalling in RA synovial fibroblasts and effectively suppressed subsequent expression of the proinflammatory mediators IL-6, MCP-1 and IP-10. baricitinib 9-20 C-C motif chemokine ligand 2 Homo sapiens 173-178 34744703-3 2021 Miconazole dose-dependently inhibited the expression of proinflammatory markers, including CCL2 and CCR5 ligands such as CCL3 and CCL4, and impaired the migration of monocytic cells and CCR5-positive T cells. Miconazole 0-10 C-C motif chemokine ligand 2 Homo sapiens 91-95 34786083-10 2021 Additionally, circulating levels of IL-1beta and MCP-1 could serve as promising prognostic markers for patients with paraquat poisoning. Paraquat 117-125 C-C motif chemokine ligand 2 Homo sapiens 49-54 34655103-11 2022 LPS exposure evoked viability reduction, increased LDH release and apoptosis, and induced production of inflammatory cytokines (IL-6, IL-8, and MCP-1) and MUC5AC hypersecretion in human AECs, which were alleviated by euxanthone. euxanthone 217-227 C-C motif chemokine ligand 2 Homo sapiens 144-149 34691228-0 2021 Triptolide Attenuates Neuropathic Pain by Regulating Microglia Polarization through the CCL2/CCR2 Axis. triptolide 0-10 C-C motif chemokine ligand 2 Homo sapiens 88-92 34691228-4 2021 In this study, the effects of triptolide on the activation and polarization of microglia cells and CCL2 and its corresponding receptor, chemokine receptor 2 (CCR2), were mainly discussed. triptolide 30-40 C-C motif chemokine ligand 2 Homo sapiens 99-103 34691228-10 2021 T10 may inhibit microglia activation and M1 polarization by inhibiting the expression of CCL2 and CCR2, promoting M2 polarization, reducing the level of inflammatory factors in cells, and exerting its analgesic effect, which is worthy of clinical promotion as a drug for neuropathic pain. t10 0-3 C-C motif chemokine ligand 2 Homo sapiens 89-93 34771561-8 2021 CCL17/TARC, sgp130, haptoglobin, B-cell activating factor (BAFF) and monocyte chemoattractant protein-1 (MCP1) were significantly (p < 0.05) associated with current smoking and correlated with increasing cotinine concentrations (Ptrend < 0.05). Cotinine 204-212 C-C motif chemokine ligand 2 Homo sapiens 69-103 34771561-8 2021 CCL17/TARC, sgp130, haptoglobin, B-cell activating factor (BAFF) and monocyte chemoattractant protein-1 (MCP1) were significantly (p < 0.05) associated with current smoking and correlated with increasing cotinine concentrations (Ptrend < 0.05). Cotinine 204-212 C-C motif chemokine ligand 2 Homo sapiens 105-109 34680177-5 2021 NMP at concentrations as low as 1 micromol/L reduced the stimulated expression of several pro-inflammatory mediators, including C-C Motif chemokine ligand (CCL)-2, C-X-C Motif chemokine ligand (CXCL)-10, and intercellular adhesion Molecule (ICAM)-1, but left the induction of prostaglandin G/H synthase (PTGS)2, interleukin (IL)-1beta, and colony stimulating factor (CSF)1 unaffected. 1-methylpyridinium 0-3 C-C motif chemokine ligand 2 Homo sapiens 128-162 34665696-9 2021 Although both TNFalpha and IL-1beta signal independently of the JAK/STAT pathway, in HSF, but not in RA FLS, baricitinib significantly inhibited TNFalpha- and IL-1beta-induced MCP-1 and IP-10 protein levels in a dose dependent manner. baricitinib 109-120 C-C motif chemokine ligand 2 Homo sapiens 176-181 34323663-12 2021 In HUVECs pre-stimulated with oxysterol, rivaroxaban decreased mRNA expression of IL-33, TNF-alpha, chemokines MCP-1, ICAM-1, VEGF and tissue factor (p < .01). Rivaroxaban 41-52 C-C motif chemokine ligand 2 Homo sapiens 111-116 34620946-0 2021 Irbesartan, an angiotensin II type 1 receptor blocker, inhibits colitis-associated tumourigenesis by blocking the MCP-1/CCR2 pathway. Irbesartan 0-10 C-C motif chemokine ligand 2 Homo sapiens 114-119 34620946-9 2021 Irbesartan suppressed MCP-1 production and the accumulation of Ly6C+CCR2+ monocytes and fibrocytes in the inflamed colon, downregulated the expression of type 1 collagen and matrix metalloproteinase 9 and inhibited the development of intestinal fibrosis and tumours. Irbesartan 0-10 C-C motif chemokine ligand 2 Homo sapiens 22-27 34620946-10 2021 Our observations suggest that blocking the MCP-1/CCR2 pathway using irbesartan might be beneficial in preventing colitis-associated colon tumours. Irbesartan 68-78 C-C motif chemokine ligand 2 Homo sapiens 43-48 34323663-10 2021 RESULTS: 25-OHC decreased endothelial cell integrity and increased the mRNA expression of IL-33, tissue factor, ICAM-1, MCP-1, VEGF, TNF-alpha as compared to unstimulated controls. 25-hydroxycholesterol 9-15 C-C motif chemokine ligand 2 Homo sapiens 120-125 34536795-8 2021 Later paracetamol treatment was associated with lower serum levels of several cytokines, including interleukin (IL-) 10, interferon gamma-induced protein (IP-) 10, and monocyte chemoattractant protein-1. Acetaminophen 6-17 C-C motif chemokine ligand 2 Homo sapiens 168-202 34323663-12 2021 In HUVECs pre-stimulated with oxysterol, rivaroxaban decreased mRNA expression of IL-33, TNF-alpha, chemokines MCP-1, ICAM-1, VEGF and tissue factor (p < .01). Oxysterols 30-39 C-C motif chemokine ligand 2 Homo sapiens 111-116 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. Quercetin 101-110 C-C motif chemokine ligand 2 Homo sapiens 261-265 34433211-9 2021 Further, logistics regression analysis showed an association of 25(OH)D with MCP-1, hematocrit, fibrinogen, and blood viscosity. 25(oh)d 64-71 C-C motif chemokine ligand 2 Homo sapiens 77-82 34560074-5 2022 CCL2 was upregulated in SDS-treated skin, and local CCL2 blockade attenuated SDS-induced ICD. Sodium Dodecyl Sulfate 24-27 C-C motif chemokine ligand 2 Homo sapiens 0-4 34560074-5 2022 CCL2 was upregulated in SDS-treated skin, and local CCL2 blockade attenuated SDS-induced ICD. Sodium Dodecyl Sulfate 77-80 C-C motif chemokine ligand 2 Homo sapiens 52-56 34495872-7 2021 Administration of IPI504 at 0.5-5 muM can significantly inhibit the induction of IL-1beta, IL-6, IL-8, MCP-1 and VEGFA in senescent ARPE-19 and the senescence-mediated migration of retinal capillary endothelial cells in vitro. tanespimycin 18-24 C-C motif chemokine ligand 2 Homo sapiens 103-108 34433211-8 2021 25(OH)D showed a significant negative correlation with MCP-1, ESR, blood viscosity, atherogenic index of plasma and FRS among total study subjects. 25(oh)d 0-7 C-C motif chemokine ligand 2 Homo sapiens 55-60 34216363-11 2021 Secondly, the excessive production of inflammatory factors (IL-1beta, IL-8, and MCP-1) and adhesion molecules (ICAM-1 and VCAM-1) triggered by propofol was pronouncedly inhibited by Benzbromarone. Propofol 143-151 C-C motif chemokine ligand 2 Homo sapiens 80-85 34216363-11 2021 Secondly, the excessive production of inflammatory factors (IL-1beta, IL-8, and MCP-1) and adhesion molecules (ICAM-1 and VCAM-1) triggered by propofol was pronouncedly inhibited by Benzbromarone. Benzbromarone 182-195 C-C motif chemokine ligand 2 Homo sapiens 80-85 34544906-7 2021 By contrast, norbixin increases matrix metalloproteinase 9 (MMP9) and C-C motif chemokine ligand 2 (CCL2) mRNA expression in response to A2E. norbixin 13-21 C-C motif chemokine ligand 2 Homo sapiens 70-98 34544906-7 2021 By contrast, norbixin increases matrix metalloproteinase 9 (MMP9) and C-C motif chemokine ligand 2 (CCL2) mRNA expression in response to A2E. norbixin 13-21 C-C motif chemokine ligand 2 Homo sapiens 100-104 34499269-0 2021 EGR1-CCL2 Feedback Loop Maintains Epithelial-Mesenchymal Transition of Cisplatin-Resistant Gastric Cancer Cells and Promotes Tumor Angiogenesis. Cisplatin 71-80 C-C motif chemokine ligand 2 Homo sapiens 5-9 34568366-5 2021 Results: IL-6, IL-8, IP-10, and MCP-1 in aqueous humor of DME vitrectomized eyes were significantly higher than in non-vitrectomized DME eyes, while VEGF was lower than in non-vitrectomized DME eyes. dme 58-61 C-C motif chemokine ligand 2 Homo sapiens 32-37 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. Berberine 122-131 C-C motif chemokine ligand 2 Homo sapiens 261-265 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. hederagenin 133-144 C-C motif chemokine ligand 2 Homo sapiens 261-265 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. shionone 146-154 C-C motif chemokine ligand 2 Homo sapiens 261-265 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. Luteolin 112-120 C-C motif chemokine ligand 2 Homo sapiens 261-265 34493195-7 2022 RESULTS: We filtered out 6 pivotal ingredients from QFPDD by using the bioinformatics method, namely quercetin, luteolin, berberine, hederagenin, shionone and kaempferol, which can inhibit the highly expressed genes (i.e. CXCR4, ICAM1, CXCL8, CXCL10, IL6, IL2, CCL2, IL1B, IL4, IFNG) in severe COVID-19 patients. kaempferol 159-169 C-C motif chemokine ligand 2 Homo sapiens 261-265 34492036-8 2021 Using a multiplex-immunoassay system, we also showed that at peak disease, PPS treatment led to a systemic reduction of the chemokines CXCL1, CCL2 (MCP-1), CCL7 (MCP-3) and CCL12 (MCP-5) which may be associated with the reduction in cellular infiltrates. Pentosan Sulfuric Polyester 75-78 C-C motif chemokine ligand 2 Homo sapiens 142-146 34492036-8 2021 Using a multiplex-immunoassay system, we also showed that at peak disease, PPS treatment led to a systemic reduction of the chemokines CXCL1, CCL2 (MCP-1), CCL7 (MCP-3) and CCL12 (MCP-5) which may be associated with the reduction in cellular infiltrates. Pentosan Sulfuric Polyester 75-78 C-C motif chemokine ligand 2 Homo sapiens 148-153 34575489-4 2021 The results showed that MNP-Dex/PCA exert an anti-inflammatory activity at non-cytotoxic and therapeutically relevant concentrations of PCA (350 muM) as supported by the reduced levels of inflammatory molecules such as MCP-1, IL-1beta, TNF-alpha, IL-6, and CCR2 in activated EC and M1-type macrophages and functional monocyte adhesion assay. protocatechuic acid 32-35 C-C motif chemokine ligand 2 Homo sapiens 219-224 34575489-4 2021 The results showed that MNP-Dex/PCA exert an anti-inflammatory activity at non-cytotoxic and therapeutically relevant concentrations of PCA (350 muM) as supported by the reduced levels of inflammatory molecules such as MCP-1, IL-1beta, TNF-alpha, IL-6, and CCR2 in activated EC and M1-type macrophages and functional monocyte adhesion assay. protocatechuic acid 136-139 C-C motif chemokine ligand 2 Homo sapiens 219-224 34533124-0 2021 (RS102895 inhibits the proliferation, invasion, and migration of PC-3 prostate cancer cells by blocking CCL2/CCR2 pathway). RS 102895 1-9 C-C motif chemokine ligand 2 Homo sapiens 104-108 34415720-0 2021 MCP-1-Functionalized, Core-Shell Gold Nanorod@Iron-Based Metal-Organic Framework (MCP-1/GNR@MIL-100(Fe)) for Photothermal Therapy. N(1)-methyl-2-lysergic acid diethylamide 92-96 C-C motif chemokine ligand 2 Homo sapiens 82-87 34512638-9 2021 In addition, 1,25D3 decreased the expression of IL-6, IFN-beta1, CCL2, FN1 and COL1A1 induced by polyI:C in BSMCs. Poly C 97-104 C-C motif chemokine ligand 2 Homo sapiens 65-69 34578925-8 2021 Significant inverse correlations were revealed for the change in MCP-1 plasma concentration and change in the consumption of vitamin C and dietary fibre both in the DASH (r = -0.519, p = 0.0005; r = -0.353, p = 0.025, respectively) and in the control group (r = -0.488 p = 0.001; r = -0.502, p = 0.001, respectively). Ascorbic Acid 125-134 C-C motif chemokine ligand 2 Homo sapiens 65-70 34512648-8 2021 In preterm infants, exposure to HCA was associated with elevations in 8 immune proteins on postnatal day 5 (BDNF, C3, C5a, C9, IL-8, MCP-1, MIP-1beta and MMP-9) when compared to preterm infants who were not exposed. hca 32-35 C-C motif chemokine ligand 2 Homo sapiens 133-138 34415720-0 2021 MCP-1-Functionalized, Core-Shell Gold Nanorod@Iron-Based Metal-Organic Framework (MCP-1/GNR@MIL-100(Fe)) for Photothermal Therapy. Iron 46-50 C-C motif chemokine ligand 2 Homo sapiens 0-5 34415720-0 2021 MCP-1-Functionalized, Core-Shell Gold Nanorod@Iron-Based Metal-Organic Framework (MCP-1/GNR@MIL-100(Fe)) for Photothermal Therapy. Iron 100-102 C-C motif chemokine ligand 2 Homo sapiens 0-5 34415720-0 2021 MCP-1-Functionalized, Core-Shell Gold Nanorod@Iron-Based Metal-Organic Framework (MCP-1/GNR@MIL-100(Fe)) for Photothermal Therapy. Iron 46-50 C-C motif chemokine ligand 2 Homo sapiens 82-87 34415720-0 2021 MCP-1-Functionalized, Core-Shell Gold Nanorod@Iron-Based Metal-Organic Framework (MCP-1/GNR@MIL-100(Fe)) for Photothermal Therapy. Metals 57-62 C-C motif chemokine ligand 2 Homo sapiens 0-5 34415720-4 2021 In this work, we successfully modified monocyte chemoattractant protein-1 (MCP-1) and iron-based metal-organic framework (MIL-100(Fe)) on the photothermal agent, gold nanorods (GNRs) (i.e., MCP-1/GNR@MIL-100(Fe)), to increase cellular uptake and biocompatibility. Iron 86-90 C-C motif chemokine ligand 2 Homo sapiens 190-195 34415720-0 2021 MCP-1-Functionalized, Core-Shell Gold Nanorod@Iron-Based Metal-Organic Framework (MCP-1/GNR@MIL-100(Fe)) for Photothermal Therapy. Metals 57-62 C-C motif chemokine ligand 2 Homo sapiens 82-87 34415720-4 2021 In this work, we successfully modified monocyte chemoattractant protein-1 (MCP-1) and iron-based metal-organic framework (MIL-100(Fe)) on the photothermal agent, gold nanorods (GNRs) (i.e., MCP-1/GNR@MIL-100(Fe)), to increase cellular uptake and biocompatibility. Metals 97-102 C-C motif chemokine ligand 2 Homo sapiens 190-195 34415720-0 2021 MCP-1-Functionalized, Core-Shell Gold Nanorod@Iron-Based Metal-Organic Framework (MCP-1/GNR@MIL-100(Fe)) for Photothermal Therapy. N(1)-methyl-2-lysergic acid diethylamide 92-96 C-C motif chemokine ligand 2 Homo sapiens 0-5 34415720-4 2021 In this work, we successfully modified monocyte chemoattractant protein-1 (MCP-1) and iron-based metal-organic framework (MIL-100(Fe)) on the photothermal agent, gold nanorods (GNRs) (i.e., MCP-1/GNR@MIL-100(Fe)), to increase cellular uptake and biocompatibility. mil-100 122-129 C-C motif chemokine ligand 2 Homo sapiens 190-195 34415720-4 2021 In this work, we successfully modified monocyte chemoattractant protein-1 (MCP-1) and iron-based metal-organic framework (MIL-100(Fe)) on the photothermal agent, gold nanorods (GNRs) (i.e., MCP-1/GNR@MIL-100(Fe)), to increase cellular uptake and biocompatibility. Iron 130-132 C-C motif chemokine ligand 2 Homo sapiens 39-73 34415720-4 2021 In this work, we successfully modified monocyte chemoattractant protein-1 (MCP-1) and iron-based metal-organic framework (MIL-100(Fe)) on the photothermal agent, gold nanorods (GNRs) (i.e., MCP-1/GNR@MIL-100(Fe)), to increase cellular uptake and biocompatibility. Iron 130-132 C-C motif chemokine ligand 2 Homo sapiens 190-195 34415720-4 2021 In this work, we successfully modified monocyte chemoattractant protein-1 (MCP-1) and iron-based metal-organic framework (MIL-100(Fe)) on the photothermal agent, gold nanorods (GNRs) (i.e., MCP-1/GNR@MIL-100(Fe)), to increase cellular uptake and biocompatibility. mil-100 200-207 C-C motif chemokine ligand 2 Homo sapiens 39-73 34415720-4 2021 In this work, we successfully modified monocyte chemoattractant protein-1 (MCP-1) and iron-based metal-organic framework (MIL-100(Fe)) on the photothermal agent, gold nanorods (GNRs) (i.e., MCP-1/GNR@MIL-100(Fe)), to increase cellular uptake and biocompatibility. mil-100 200-207 C-C motif chemokine ligand 2 Homo sapiens 75-80 34415720-4 2021 In this work, we successfully modified monocyte chemoattractant protein-1 (MCP-1) and iron-based metal-organic framework (MIL-100(Fe)) on the photothermal agent, gold nanorods (GNRs) (i.e., MCP-1/GNR@MIL-100(Fe)), to increase cellular uptake and biocompatibility. mil-100 200-207 C-C motif chemokine ligand 2 Homo sapiens 190-195 34415720-4 2021 In this work, we successfully modified monocyte chemoattractant protein-1 (MCP-1) and iron-based metal-organic framework (MIL-100(Fe)) on the photothermal agent, gold nanorods (GNRs) (i.e., MCP-1/GNR@MIL-100(Fe)), to increase cellular uptake and biocompatibility. Iron 208-210 C-C motif chemokine ligand 2 Homo sapiens 39-73 34415720-4 2021 In this work, we successfully modified monocyte chemoattractant protein-1 (MCP-1) and iron-based metal-organic framework (MIL-100(Fe)) on the photothermal agent, gold nanorods (GNRs) (i.e., MCP-1/GNR@MIL-100(Fe)), to increase cellular uptake and biocompatibility. Iron 208-210 C-C motif chemokine ligand 2 Homo sapiens 75-80 34415720-4 2021 In this work, we successfully modified monocyte chemoattractant protein-1 (MCP-1) and iron-based metal-organic framework (MIL-100(Fe)) on the photothermal agent, gold nanorods (GNRs) (i.e., MCP-1/GNR@MIL-100(Fe)), to increase cellular uptake and biocompatibility. Iron 208-210 C-C motif chemokine ligand 2 Homo sapiens 190-195 34415720-5 2021 The results of TEM, UV-vis, and FTIR all confirmed that we"d synthesized MCP-1/GNR@MIL-100(Fe) successfully, and the MCP-1/GNR@MIL-100(Fe) also showed good biocompatibility. N(1)-methyl-2-lysergic acid diethylamide 83-86 C-C motif chemokine ligand 2 Homo sapiens 73-78 34415720-5 2021 The results of TEM, UV-vis, and FTIR all confirmed that we"d synthesized MCP-1/GNR@MIL-100(Fe) successfully, and the MCP-1/GNR@MIL-100(Fe) also showed good biocompatibility. Iron 91-93 C-C motif chemokine ligand 2 Homo sapiens 73-78 34415720-5 2021 The results of TEM, UV-vis, and FTIR all confirmed that we"d synthesized MCP-1/GNR@MIL-100(Fe) successfully, and the MCP-1/GNR@MIL-100(Fe) also showed good biocompatibility. N(1)-methyl-2-lysergic acid diethylamide 127-130 C-C motif chemokine ligand 2 Homo sapiens 117-122 34415720-5 2021 The results of TEM, UV-vis, and FTIR all confirmed that we"d synthesized MCP-1/GNR@MIL-100(Fe) successfully, and the MCP-1/GNR@MIL-100(Fe) also showed good biocompatibility. Iron 135-137 C-C motif chemokine ligand 2 Homo sapiens 117-122 34603672-2 2021 Tetrachloroallene Cl2C(double bond, length as m-dash)C(double bond, length as m-dash)CCl2 was identified as the first intermediate of the reaction cascade. tetrachloroallene cl2c 0-22 C-C motif chemokine ligand 2 Homo sapiens 85-89 34415898-9 2021 Overall, IL-4 levels did not change significantly over time in either group; however, patients within the CE3b group showed a significant decrease of IL-1ra, IL-6, IL-8, G-CSF, IFN-gamma, IP-10, MCP-1, MIP-1alpha, FGF at T1 compared to T0 (p<=0.042). ce3b 106-110 C-C motif chemokine ligand 2 Homo sapiens 195-200 34452519-12 2021 Astodrimer sodium 1% significantly reduced the pro-inflammatory cytokines IL-6, IL-1alpha, IL-1beta, TNFalpha and TGFbeta and the chemokine MCP-1 in the serum, lung and trachea vs. PBS. astodrimer sodium 0-17 C-C motif chemokine ligand 2 Homo sapiens 140-145 34443321-3 2021 The effect of BBR on AA/LPS activated proinflammatory markers including TNF-alpha, MCP-1, IL-8 and COX-2 was measured by ELISA or quantitative real-time PCR. Berberine 14-17 C-C motif chemokine ligand 2 Homo sapiens 83-88 34369225-9 2022 The magnitude of reduction in VEGF ranged between -1.24 for sucrose to 4.49 for glucose intake, and -2.64 for fructose intake for MCP-1 levels. Fructose 110-118 C-C motif chemokine ligand 2 Homo sapiens 130-135 34443321-5 2021 AA/ LPS-induced TNF-alpha, MCP-1, IL-6, IL-8, and COX-2 markers were markedly attenuated by BBR treatment in THP-1 cells by inhibiting NF-kappaB translocation into the nucleus. Berberine 92-95 C-C motif chemokine ligand 2 Homo sapiens 27-32 34214498-7 2021 SARS-CoV-2-infected cells treated with famotidine demonstrate reduced expression levels of the inflammatory mediators CCL-2 and IL6, drivers of the cytokine release syndrome that precipitates poor outcome for patients with COVID-19. Famotidine 39-49 C-C motif chemokine ligand 2 Homo sapiens 118-123 34110092-7 2021 Our findings suggest that p-gliadin composed of supramolecular structures triggers significant mRNA up-regulation (p < 0.05) of pro-apoptotic biomarkers (ratio Bcl2/Bak-1), chemokines (CCL2, CCL3, CCL4, CCL5, CXCL8) and the chemokine receptor CXCR3. p-gliadin 26-35 C-C motif chemokine ligand 2 Homo sapiens 185-189 34439789-6 2021 Significant correlations were found with PHE volume for IL-6, IL-10 and CCL2 at day 1-2 and with relative PHE at days 7-8 or 9-10 for IL-1beta, IL-6, IL-8, and IL-10. Phenylalanine 41-44 C-C motif chemokine ligand 2 Homo sapiens 72-76 34080237-6 2021 Compared with baseline, serum levels of IL-6, TNF-alpha, MCP-1 and CRP were significantly reduced in patients receiving curcuminoids (p < .05) without any significant changes in placebo group; however, changes in the activities of GPx and SOD in serum were not significant between two groups. Diarylheptanoids 120-132 C-C motif chemokine ligand 2 Homo sapiens 57-62 34330322-8 2021 The serum level of CCL2 was reduced in 7 of 9 patients after paquinimod treatment. paquinimod 61-71 C-C motif chemokine ligand 2 Homo sapiens 19-23 34385920-5 2021 Real-time gene expression assay for intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) was carried out following treatment with quercetin at 15 and 30 muM for 24 h either in the absence or presence of interferon (IFN-gamma) for 3 h to induce inflammation. Quercetin 167-176 C-C motif chemokine ligand 2 Homo sapiens 83-117 34385920-5 2021 Real-time gene expression assay for intercellular adhesion molecule-1 (ICAM-1) and monocyte chemoattractant protein-1 (MCP-1) was carried out following treatment with quercetin at 15 and 30 muM for 24 h either in the absence or presence of interferon (IFN-gamma) for 3 h to induce inflammation. Quercetin 167-176 C-C motif chemokine ligand 2 Homo sapiens 119-124 34385920-13 2021 Conclusion: Our results from both in vitro and in silico studies identified that quercetin inhibited the THP-1 monocyte migration, MCP-1, and ICAM-1 and increased cholesterol efflux probably mediated via the LXR/RXR signaling pathway. Quercetin 81-90 C-C motif chemokine ligand 2 Homo sapiens 131-136 34289902-5 2021 The levels of monocyte chemoattractant protein-1 (MCP-1) indicated a trend towards significance across tertiles of total dietary carbohydrate. Carbohydrates 129-141 C-C motif chemokine ligand 2 Homo sapiens 14-48 34289902-5 2021 The levels of monocyte chemoattractant protein-1 (MCP-1) indicated a trend towards significance across tertiles of total dietary carbohydrate. Carbohydrates 129-141 C-C motif chemokine ligand 2 Homo sapiens 50-55 34289902-7 2021 In addition, the levels of MCP-1 and transforming growth factor beta (TGF-beta) were positively correlated to dietary carbohydrate. Dietary Carbohydrates 110-130 C-C motif chemokine ligand 2 Homo sapiens 27-32 34282217-8 2021 DZA treatment also significantly reduced adipocyte differentiation factors, impaired adiponectin and leptin secretion but increased release of pro-inflammatory cytokines, IL-6, TNF and MCP-1. 3-deazaadenosine 0-3 C-C motif chemokine ligand 2 Homo sapiens 185-190 34285296-6 2021 Inflammatory markers induced by TNF-alpha, including IL-1, IL-6, MCP-1 and RANTES, were also suppressed following administration of clodronate. Clodronic Acid 132-142 C-C motif chemokine ligand 2 Homo sapiens 65-70 34280220-3 2021 TG6-44 significantly decreased A/X31-induced ROS and virus-induced inflammatory mediators in THP-1 cells (IL-6, IFN-gamma, MCP-1, TNF-alpha, MIP-1beta) and in human PBMC (IL-6, IL-8, TNF-alpha, MCP-1). 6-O-phosphono-D-tagatose 0-3 C-C motif chemokine ligand 2 Homo sapiens 123-128 34280220-3 2021 TG6-44 significantly decreased A/X31-induced ROS and virus-induced inflammatory mediators in THP-1 cells (IL-6, IFN-gamma, MCP-1, TNF-alpha, MIP-1beta) and in human PBMC (IL-6, IL-8, TNF-alpha, MCP-1). 6-O-phosphono-D-tagatose 0-3 C-C motif chemokine ligand 2 Homo sapiens 194-199 34299258-5 2021 Resveratrol inhibited degranulation and expression of cytokines and chemokines such as CXCL8, CCL2, CCL3, CCL4, and TNF-alpha in a dose-dependent manner. Resveratrol 0-11 C-C motif chemokine ligand 2 Homo sapiens 94-98 34274535-3 2022 Here, we show that the primary TNBC tumor-derived C-X-C motif chemokines 1/2/8 (CXCL1/2/8) stimulate lung resident fibroblasts to produce C-C motif chemokines 2/7 (CCL2/7), which in turn activate cholesterol synthesis in lung-colonizing TNBC cells and induce angiogenesis at lung metastatic sites. Cholesterol 196-207 C-C motif chemokine ligand 2 Homo sapiens 138-162 34447239-10 2021 Results: AMCM downregulated the mRNA levels of CCL2, CCL5, CXCL10, MDA5, RIG-1, and TLR3. amcm 9-13 C-C motif chemokine ligand 2 Homo sapiens 47-51 34299030-8 2021 TNFalpha stimulated the cytokine expression in FLS, and NDMVs down-regulated TNFalpha-induced expression of IL-5, IL-6, IL-8, MCP-1, IFNgamma and MIP-1beta. ndmvs 56-61 C-C motif chemokine ligand 2 Homo sapiens 126-131 34261550-11 2021 Cannabinoid-related reductions of MCP-1 and IP-10, if confirmed, suggest a role for medicinal cannabis in the mitigation of persistent inflammation and cognitive impacts of HIV. Cannabinoids 0-11 C-C motif chemokine ligand 2 Homo sapiens 34-39 34147675-8 2022 Cholesterol accumulation in cardiac muscle cells can result in a significant increase in the levels of BNP, inflammatory factors (IL-1beta, IL-6, TNF-alpha and CCL-2) in cardiac muscle cells, which exacerbates cardiomyocyte damage. Cholesterol 0-11 C-C motif chemokine ligand 2 Homo sapiens 160-165 34371879-7 2021 We found that all corticosteroid combinations strongly reduced the cytokine response on RNA- and protein levels, while high-dose vitamin C alone significantly diminished the PBMC mediated secretion of the cytokines interleukin (IL)-10, IL-23, and monocyte chemo-attractant protein (MCP-1), which mediate the inflammatory response. Ascorbic Acid 129-138 C-C motif chemokine ligand 2 Homo sapiens 282-287 34162132-8 2021 Furthermore, safinamide suppressed the production of CXCL1 and CCL2, thereby preventing leukocyte migration. safinamide 13-23 C-C motif chemokine ligand 2 Homo sapiens 63-67 34372493-6 2021 Plasma IL-8, Ccl2, VEGF, and 8-isoprostane loaded onto one factor that was highest in the HIV+/METH+ group (p < 0.047) reflecting worse inflammation, vascular injury, and oxidative stress. Methamphetamine 95-99 C-C motif chemokine ligand 2 Homo sapiens 13-17 34248953-11 2021 OSM-induced secretion of MCP-1 and IL-6 was inhibited by all JAKi with Peficitinib, Baricitinib and Upadacitinib showing the greatest effect. baricitinib 84-95 C-C motif chemokine ligand 2 Homo sapiens 25-30 34248953-11 2021 OSM-induced secretion of MCP-1 and IL-6 was inhibited by all JAKi with Peficitinib, Baricitinib and Upadacitinib showing the greatest effect. upadacitinib 100-112 C-C motif chemokine ligand 2 Homo sapiens 25-30 34447239-11 2021 In addition, AMCM decreased secretion of CCL2, CCL5, and CXCL10 and translocation of nuclear NF-kappaB. amcm 13-17 C-C motif chemokine ligand 2 Homo sapiens 41-45 34447239-14 2021 The administration of rh-lumican to poly I:C-stimulated HLMs reduced the mRNA levels of CCL2, CCL5, and CXCL10. rh-lumican 22-32 C-C motif chemokine ligand 2 Homo sapiens 88-92 34447239-14 2021 The administration of rh-lumican to poly I:C-stimulated HLMs reduced the mRNA levels of CCL2, CCL5, and CXCL10. Poly I 36-42 C-C motif chemokine ligand 2 Homo sapiens 88-92 34447239-14 2021 The administration of rh-lumican to poly I:C-stimulated HLMs reduced the mRNA levels of CCL2, CCL5, and CXCL10. Carbon 43-44 C-C motif chemokine ligand 2 Homo sapiens 88-92 34178639-8 2021 The recruitment of TAMs and the secretion of CCL2 were dramatically reduced after LDHA was knocked down in vitro and in vivo. tams 19-23 C-C motif chemokine ligand 2 Homo sapiens 45-49 34178725-11 2021 Inhibition of miR-548d-3p reduced parasite growth early after infection and increased production of MCP1/CCL2, RANTES/CCL5, and IP10/CXCL10. mir-548d-3p 14-25 C-C motif chemokine ligand 2 Homo sapiens 100-104 34179086-5 2021 RT-qPCR was used to detect the mRNA expression of inflammatory cytokines (CCL2, IL-8, CCL4) and genes associated with angiogenesis (VEGF, ANG-1, ANG-2) in early EPCs after treatment of LPC (10 mug/ml) or phosphatidylcholine (PC, 10 mug/ml, control). Lysophosphatidylcholines 185-188 C-C motif chemokine ligand 2 Homo sapiens 74-78 34179086-5 2021 RT-qPCR was used to detect the mRNA expression of inflammatory cytokines (CCL2, IL-8, CCL4) and genes associated with angiogenesis (VEGF, ANG-1, ANG-2) in early EPCs after treatment of LPC (10 mug/ml) or phosphatidylcholine (PC, 10 mug/ml, control). Phosphatidylcholines 204-223 C-C motif chemokine ligand 2 Homo sapiens 74-78 34178725-11 2021 Inhibition of miR-548d-3p reduced parasite growth early after infection and increased production of MCP1/CCL2, RANTES/CCL5, and IP10/CXCL10. mir-548d-3p 14-25 C-C motif chemokine ligand 2 Homo sapiens 105-109 34112803-4 2021 Here, we show that microenvironmental cytokines, particularly CCL2, decorate cancer exosomes via binding to surface glycosaminoglycan side chains of proteoglycans, causing exosome accumulation in specific cell subsets and organs. Glycosaminoglycans 116-133 C-C motif chemokine ligand 2 Homo sapiens 62-66 34086734-0 2021 Dose- and time-dependent changes in viability and IL-6, CXCL8 and CCL2 production by HaCaT-cells exposed to cobalt. Cobalt 108-114 C-C motif chemokine ligand 2 Homo sapiens 66-70 34179166-10 2021 Flu Avert treatment resulted in the modulation of IL-8, CCL2, and CXCL9 starting at days 5 and 6 post-treatment. flu avert 0-9 C-C motif chemokine ligand 2 Homo sapiens 56-60 34086734-12 2021 A linear mixed statistical model showed that cobalt exposure induces increase in IL-6, CXCL8 and CCL2 production over time and whereas increase of IL-6 and a decrease of CCL2 was associated with increasing cobalt chloride concentrations. Cobalt 45-51 C-C motif chemokine ligand 2 Homo sapiens 97-101 34086734-12 2021 A linear mixed statistical model showed that cobalt exposure induces increase in IL-6, CXCL8 and CCL2 production over time and whereas increase of IL-6 and a decrease of CCL2 was associated with increasing cobalt chloride concentrations. cobaltous chloride 206-221 C-C motif chemokine ligand 2 Homo sapiens 170-174 34077680-4 2021 ZMO exhibited anti-inflammatory capacity by inhibiting the formation of pro-inflammatory markers such as nitric oxide, inducible nitric oxide synthase, cyclooxygenase-2, interleukin (IL)-1beta, IL-6, and monocyte chemoattractant protein-1 in LPS-treated macrophages. S-[2-({n-[(2s)-2-Hydroxy-3,3-Dimethyl-4-(Phosphonooxy)butanoyl]-Beta-Alanyl}amino)ethyl] (9z)-Hexadec-9-Enethioate 0-3 C-C motif chemokine ligand 2 Homo sapiens 204-238 34075171-3 2021 cDNA microarray analysis revealed that 1841 genes including CCL2, IFIT3, CPQ were commonly up-regulated in senescent BECs cultured in serum depleted media or media with glycochenodeoxycholic acid. Glycochenodeoxycholic Acid 169-195 C-C motif chemokine ligand 2 Homo sapiens 60-64 34981477-0 2021 The Role of Chemokines in Cardiovascular Diseases and the Therapeutic Effect of Curcumin on CXCL8 and CCL2 as Pathological Chemokines in Atherosclerosis. Curcumin 80-88 C-C motif chemokine ligand 2 Homo sapiens 102-106 34072916-5 2021 However, auranofin significantly inhibited the levels of NO, monocyte chemoattractant protein-1, and pro-inflammatory cytokines, such as interleukin (IL)-1beta, tumor necrosis factor-alpha, and IL-6, which had been increased by co-treatment with PA and LPS. Auranofin 9-18 C-C motif chemokine ligand 2 Homo sapiens 61-95 34072916-5 2021 However, auranofin significantly inhibited the levels of NO, monocyte chemoattractant protein-1, and pro-inflammatory cytokines, such as interleukin (IL)-1beta, tumor necrosis factor-alpha, and IL-6, which had been increased by co-treatment with PA and LPS. Palmitic Acid 246-248 C-C motif chemokine ligand 2 Homo sapiens 61-95 34140879-11 2021 The tight correlation of SELENBP1 with CCL2 levels provides a novel link between Se metabolism and immune cell activation, with potential relevance for neurological damage and regeneration processes, respectively. Selenium 81-83 C-C motif chemokine ligand 2 Homo sapiens 39-43 34064989-2 2021 We recently presented first evidence for anti-inflammatory potential of empagliflozin (Empa) under normoglycemic conditions in human proximal tubular cells (HPTC) by demonstrating Empa-mediated inhibition of IL-1beta-induced MCP-1/CCL2 and ET-1 expression on the mRNA and protein level. empagliflozin 72-85 C-C motif chemokine ligand 2 Homo sapiens 225-230 34064989-2 2021 We recently presented first evidence for anti-inflammatory potential of empagliflozin (Empa) under normoglycemic conditions in human proximal tubular cells (HPTC) by demonstrating Empa-mediated inhibition of IL-1beta-induced MCP-1/CCL2 and ET-1 expression on the mRNA and protein level. empagliflozin 72-85 C-C motif chemokine ligand 2 Homo sapiens 231-235 34064989-2 2021 We recently presented first evidence for anti-inflammatory potential of empagliflozin (Empa) under normoglycemic conditions in human proximal tubular cells (HPTC) by demonstrating Empa-mediated inhibition of IL-1beta-induced MCP-1/CCL2 and ET-1 expression on the mRNA and protein level. empagliflozin 180-184 C-C motif chemokine ligand 2 Homo sapiens 225-230 34104228-4 2021 Lurbinectedin may also modulate the tumor microenvironment by inducing apoptosis of peripheral blood monocytes and tumor associated macrophages, decreasing expression of the inflammatory chemokine (C-C motif) ligand 2 (CCL2) and reducing tumor angiogenesis. PM 01183 0-13 C-C motif chemokine ligand 2 Homo sapiens 187-217 34104228-4 2021 Lurbinectedin may also modulate the tumor microenvironment by inducing apoptosis of peripheral blood monocytes and tumor associated macrophages, decreasing expression of the inflammatory chemokine (C-C motif) ligand 2 (CCL2) and reducing tumor angiogenesis. PM 01183 0-13 C-C motif chemokine ligand 2 Homo sapiens 219-223 35306042-11 2022 TFH decreased the levels of IL-1alpha, IL-1beta, IL-6, monocyte chemoattractant protein (MCP)-1, MCP-3, macrophage-derived chemokine (MDC), platelet-derived growth factor (PDGF)-BB, thymus and activation regulated chemokine (TARC) in the supernatants of the HaCaT cells treated by IFN-gamma/TNF-alpha. tfh 0-3 C-C motif chemokine ligand 2 Homo sapiens 55-95 35533545-9 2022 The results suggested that ameliorating cisplatin-induced AKI actions of 9b was involved in downregulation of TNF-alpha, IL-1beta, IL-6, and MCP-1, inhibition of NF-kB activation, and reduction of GRPR and oxidative stress level. Cisplatin 40-49 C-C motif chemokine ligand 2 Homo sapiens 141-146 35411649-9 2022 C-C motif chemokine ligand (CCL) 2 and CCL22 were co-expressed with histamine H1 and H2 receptors. Histamine 68-77 C-C motif chemokine ligand 2 Homo sapiens 0-34 35357422-3 2022 Here we present the crystal structure of VPS13s adaptor binding domain (VAB) complexed with a Pro-X-Pro peptide recognition motif present in one such receptor, the integral membrane protein Mcp1p, and show biochemically that other Pro-X-Pro motifs bind the VAB in the same site. pro-x-pro peptide 94-111 C-C motif chemokine ligand 2 Homo sapiens 190-195 35357422-3 2022 Here we present the crystal structure of VPS13s adaptor binding domain (VAB) complexed with a Pro-X-Pro peptide recognition motif present in one such receptor, the integral membrane protein Mcp1p, and show biochemically that other Pro-X-Pro motifs bind the VAB in the same site. pro-x-pro 231-240 C-C motif chemokine ligand 2 Homo sapiens 190-195 35635326-3 2022 We hypothesised that the reduction in KIM-1 observed with the SGLT2 inhibitor canagliflozin is mediated through its effect on UACR and MCP-1. Canagliflozin 78-91 C-C motif chemokine ligand 2 Homo sapiens 135-140 35278152-12 2022 The transfection of miR-629-3p mimics inhibited 16HBE cells" viability, and promoted the apoptosis and the secretion of chemokines CCL11, CCL26, CCL-2/MCP-1, IL-1b, and IL-6 of 16HBE cells, whereas inhibiting miR-629-3p had the opposite effects. mir-629-3p 20-30 C-C motif chemokine ligand 2 Homo sapiens 145-150 35623848-6 2022 The bioactive compounds including luteolin, epicatechin, epigallocatechin gallate, lycopene, quercetin, vitamin A, vitamin C and vitamin E in FBV significantly lowered TNF-alpha production, CCL2 production, IL-1beta production, and reactive oxygen species production. Vitamin A 104-113 C-C motif chemokine ligand 2 Homo sapiens 190-194 35623848-6 2022 The bioactive compounds including luteolin, epicatechin, epigallocatechin gallate, lycopene, quercetin, vitamin A, vitamin C and vitamin E in FBV significantly lowered TNF-alpha production, CCL2 production, IL-1beta production, and reactive oxygen species production. Ascorbic Acid 115-124 C-C motif chemokine ligand 2 Homo sapiens 190-194 35623848-6 2022 The bioactive compounds including luteolin, epicatechin, epigallocatechin gallate, lycopene, quercetin, vitamin A, vitamin C and vitamin E in FBV significantly lowered TNF-alpha production, CCL2 production, IL-1beta production, and reactive oxygen species production. Vitamin E 129-138 C-C motif chemokine ligand 2 Homo sapiens 190-194 35122447-6 2022 Gefitinib enhanced the TNFalpha-induced expression of C-C motif chemokine ligand 2 (CCL2), CCL5, and C-X-C motif chemokine ligand 10 (CXCL10), and the expression of TNFalpha in HaCaT cells, while EGF restored these changes. Gefitinib 0-9 C-C motif chemokine ligand 2 Homo sapiens 54-82 35122447-6 2022 Gefitinib enhanced the TNFalpha-induced expression of C-C motif chemokine ligand 2 (CCL2), CCL5, and C-X-C motif chemokine ligand 10 (CXCL10), and the expression of TNFalpha in HaCaT cells, while EGF restored these changes. Gefitinib 0-9 C-C motif chemokine ligand 2 Homo sapiens 84-88 35417091-8 2022 Here, we demonstrate that apabetalone, a BD2-selective BETi, dose dependently reduced the production of MCP-1 and IL-12 in stimulated PBMCs through transcriptional regulation of their encoding genes. apabetalone 26-37 C-C motif chemokine ligand 2 Homo sapiens 104-109 35417091-8 2022 Here, we demonstrate that apabetalone, a BD2-selective BETi, dose dependently reduced the production of MCP-1 and IL-12 in stimulated PBMCs through transcriptional regulation of their encoding genes. beti 55-59 C-C motif chemokine ligand 2 Homo sapiens 104-109 35623848-6 2022 The bioactive compounds including luteolin, epicatechin, epigallocatechin gallate, lycopene, quercetin, vitamin A, vitamin C and vitamin E in FBV significantly lowered TNF-alpha production, CCL2 production, IL-1beta production, and reactive oxygen species production. Luteolin 34-42 C-C motif chemokine ligand 2 Homo sapiens 190-194 35635326-4 2022 To test this hypothesis, we assessed the proportion of effect of canagliflozin on KIM-1 mediated through its effects on MCP-1 and UACR in patients with type 2 diabetes and albuminuric kidney disease. Canagliflozin 65-78 C-C motif chemokine ligand 2 Homo sapiens 120-125 35635326-7 2022 The proportion of mediated effect of canagliflozin through UACR and MCP-1/Cr on KIM-1/Cr was estimated with G-computation. Canagliflozin 37-50 C-C motif chemokine ligand 2 Homo sapiens 68-73 35635326-10 2022 At year 1, canagliflozin compared to placebo reduced UACR, MCP-1/Cr, and KIM-1/Cr by 40.4% (95%CI 31.0, 48.4), 18.1% (95%CI 8.9, 26.4), and 30.9% (95%CI 23.0, 38.0), respectively. Canagliflozin 11-24 C-C motif chemokine ligand 2 Homo sapiens 59-64 35635326-11 2022 The proportion of the effect of canagliflozin on KIM-1/Cr mediated by its effect on UACR and in turn on MCP-1/Cr was 15.2% (95%CI 9.4, 24.5). Canagliflozin 32-45 C-C motif chemokine ligand 2 Homo sapiens 104-109 35609975-8 2022 Using a 200 microg/microL solution of MCP-1 in phosphate-buffered saline, we showed that CG910 coated coils provide effective release of MCP over time. Phosphate-Buffered Saline 47-72 C-C motif chemokine ligand 2 Homo sapiens 38-43 35609975-8 2022 Using a 200 microg/microL solution of MCP-1 in phosphate-buffered saline, we showed that CG910 coated coils provide effective release of MCP over time. cg910 89-94 C-C motif chemokine ligand 2 Homo sapiens 38-43 35572824-0 2022 Effect of Yiqi Huayu Pinggan Zishen Formula Combined with Valsartan in the Treatment of Hypertension and Its Effect on MMP-9, Ang II, and MCP-1. Valsartan 58-67 C-C motif chemokine ligand 2 Homo sapiens 138-143 35630678-6 2022 Molecular docking results indicate that fucoidan has a greater affinity for L-and E-selectin, monocyte chemoattractant protein 1 (MCP-1), and intercellular adhesion molecule-1 (ICAM-1) as compared to alginate. fucoidan 40-48 C-C motif chemokine ligand 2 Homo sapiens 94-128 35527392-7 2022 NaCl significantly upregulated chemotactic cytokines, most markedly CCL26, CCL2 and CSF1. Sodium Chloride 0-4 C-C motif chemokine ligand 2 Homo sapiens 75-79 35606882-5 2022 The results of the present study showed that nano-curcumin can significantly reduce MCP-1 serum levels in the nano-curcumin supplemented group (P = 0.015, size effect = 13.4%). Curcumin 50-58 C-C motif chemokine ligand 2 Homo sapiens 84-89 35606882-5 2022 The results of the present study showed that nano-curcumin can significantly reduce MCP-1 serum levels in the nano-curcumin supplemented group (P = 0.015, size effect = 13.4%). Curcumin 115-123 C-C motif chemokine ligand 2 Homo sapiens 84-89 35570218-3 2022 The structure of the CCL2-CCR2-G-protein complex reveals that CCL2 inserts deeply into the extracellular half of the transmembrane domain, and forms substantial interactions with the receptor through the most N-terminal glutamine. Glutamine 220-229 C-C motif chemokine ligand 2 Homo sapiens 21-25 35570218-3 2022 The structure of the CCL2-CCR2-G-protein complex reveals that CCL2 inserts deeply into the extracellular half of the transmembrane domain, and forms substantial interactions with the receptor through the most N-terminal glutamine. Glutamine 220-229 C-C motif chemokine ligand 2 Homo sapiens 62-66 35570279-5 2022 RESULTS: HRV-Cs infect and propagate in fully differentiated HBE cells and significantly increase the secretion of IFN-lambda1, CCL5, IP10, IL-6, IL-8, and MCP-1. hrv-cs 9-15 C-C motif chemokine ligand 2 Homo sapiens 156-161 35574720-8 2022 Kaempferol down-regulated the mRNA expression levels of TNF-alpha, IL-6, and CCL2 in oxaliplatin-treated astrocytes. kaempferol 0-10 C-C motif chemokine ligand 2 Homo sapiens 77-81 35574720-8 2022 Kaempferol down-regulated the mRNA expression levels of TNF-alpha, IL-6, and CCL2 in oxaliplatin-treated astrocytes. Oxaliplatin 85-96 C-C motif chemokine ligand 2 Homo sapiens 77-81 35572824-1 2022 Objective: To explore the effect of Yiqi Huayu Pinggan Zishen recipe combined with valsartan in the treatment of hypertension and its effect on MMP-9, Ang II, and MCP-1. Valsartan 83-92 C-C motif chemokine ligand 2 Homo sapiens 163-168 35572824-18 2022 Conclusion: Yiqi Huayu Pinggan Zishen recipe combined with valsartan in the treatment of hypertension can remarkably reduce the clinical symptoms, enhance the renal function, strengthen the therapeutic effect, promote the ability of independent movement, and reduce the levels of serum MMP-9, MCP-1, and Ang II with high safety, which has the value of clinical application. Valsartan 59-68 C-C motif chemokine ligand 2 Homo sapiens 293-298 35178826-6 2022 More importantly, CCL2 and CCR2 were significantly upregulated in temozolomide (TMZ)-resistant glioma. Temozolomide 66-78 C-C motif chemokine ligand 2 Homo sapiens 18-22 35565057-11 2022 CMap-CTD database analyses indicated the expression levels of Tlr2, Ccl2, Cxcl10, Fas, Irf8, Socs3, Stat3, Gbp6, Casp1 and Syk could be reversed by folic acid. Folic Acid 148-158 C-C motif chemokine ligand 2 Homo sapiens 68-72 35565057-12 2022 Crhbp and Gdf6 were also verified to be downregulated, while Tlr2, Ccl2, Irf8, Socs3 and Stat3 were upregulated in hypoxia/H2O2-induced retinal injury models. Hydrogen Peroxide 123-127 C-C motif chemokine ligand 2 Homo sapiens 67-71 35525835-12 2022 CONCLUSIONS: PMX-DHP combined with steroid pulse therapy might reduce GRO, IL-10, IL-1Ra, IL-5, IL-6, and MCP-1 levels in ARF, contributing to better oxygenation in the disorder. 1,4-dihydropyridine 17-20 C-C motif chemokine ligand 2 Homo sapiens 106-111 35525835-12 2022 CONCLUSIONS: PMX-DHP combined with steroid pulse therapy might reduce GRO, IL-10, IL-1Ra, IL-5, IL-6, and MCP-1 levels in ARF, contributing to better oxygenation in the disorder. Steroids 35-42 C-C motif chemokine ligand 2 Homo sapiens 106-111 35178826-6 2022 More importantly, CCL2 and CCR2 were significantly upregulated in temozolomide (TMZ)-resistant glioma. Temozolomide 80-83 C-C motif chemokine ligand 2 Homo sapiens 18-22 35178826-7 2022 TMZ-resistant malignant glioblastoma cells (U251/TMZ) had higher expressions of CCL2 and CCR2 and a higher level of glycolysis as compared to its parental cell line U251. Temozolomide 0-3 C-C motif chemokine ligand 2 Homo sapiens 80-84 35178826-9 2022 Overexpression of CCL2 reduced TMZ-induced apoptosis through activation of the AKT pathway and promotion of glycolysis. Temozolomide 31-34 C-C motif chemokine ligand 2 Homo sapiens 18-22 35178826-10 2022 Moreover, overexpression of CCL2 significantly reduced the antitumor effect of TMZ in vivo. Temozolomide 79-82 C-C motif chemokine ligand 2 Homo sapiens 28-32 35178826-11 2022 In conclusion, CCL2 overexpression reduced the antitumor effect of TMZ by enhancing glycolysis through activation of AKT signaling. Temozolomide 67-70 C-C motif chemokine ligand 2 Homo sapiens 15-19 35183036-6 2022 The findings of our study suggest the potential of CCL2-mediated monocytes as a target for PDAC treatment. pdac 91-95 C-C motif chemokine ligand 2 Homo sapiens 51-55 35397443-0 2022 Di-n-butyl phthalate promotes monocyte recruitment via miR-137-3p-SP1-MCP-1 pathway. Dibutyl Phthalate 0-20 C-C motif chemokine ligand 2 Homo sapiens 70-75 35015114-7 2022 In retinal ischemia reperfusion injury, curcumin downregulates IL-17, IL-23, NFKB, STAT-3, MCP-1 and JNK. Curcumin 40-48 C-C motif chemokine ligand 2 Homo sapiens 91-96 35593365-12 2022 The results indicated that quercetin and wogonin had better affinity with CXCL8, CCL2 or IL1B. Quercetin 27-36 C-C motif chemokine ligand 2 Homo sapiens 81-85 35403296-9 2022 After vitamin D supplementation for 90 days, T2DM patients had a 2-fold increase of GSH levels, from 2.72 +- 0.84 to 5.76 +- 3.19 mumol/ml, the concentration of MCP-1 decreased from 51.11 +- 20.86 to 25.42 +- 13.06 pg/ml, and IL-8 also decreased from 38.21 +- 21.76 to 16.05 +- 8.99 pg/ml. Vitamin D 6-15 C-C motif chemokine ligand 2 Homo sapiens 161-166 35403296-10 2022 In conclusion, our study demonstrated that vitamin D could regulate the production of GSH, thereby reducing the serum levels of MCP-1 and IL-8, alleviating oxidative stress and inflammation, providing evidence of the necessity and feasibility of adjuvant vitamin D treatment among patients with T2DM. Vitamin D 43-52 C-C motif chemokine ligand 2 Homo sapiens 128-133 35403296-10 2022 In conclusion, our study demonstrated that vitamin D could regulate the production of GSH, thereby reducing the serum levels of MCP-1 and IL-8, alleviating oxidative stress and inflammation, providing evidence of the necessity and feasibility of adjuvant vitamin D treatment among patients with T2DM. Glutathione 86-89 C-C motif chemokine ligand 2 Homo sapiens 128-133 35093482-10 2022 Lisinopril abrogated radiation-induced increases in BALF MCP-1 (CCL2) and MIP-1alpha cytokine levels (p < 0.0001). Lisinopril 0-10 C-C motif chemokine ligand 2 Homo sapiens 57-62 35093482-10 2022 Lisinopril abrogated radiation-induced increases in BALF MCP-1 (CCL2) and MIP-1alpha cytokine levels (p < 0.0001). Lisinopril 0-10 C-C motif chemokine ligand 2 Homo sapiens 64-68 35593365-12 2022 The results indicated that quercetin and wogonin had better affinity with CXCL8, CCL2 or IL1B. wogonin 41-48 C-C motif chemokine ligand 2 Homo sapiens 81-85 35593365-14 2022 The expression CXCL8, CCL2 or IL1B were down-regulated after quercetin or wogonin treating, compared with LPS-induced A549 cells (P < 0.01). Quercetin 61-70 C-C motif chemokine ligand 2 Homo sapiens 22-26 35593365-14 2022 The expression CXCL8, CCL2 or IL1B were down-regulated after quercetin or wogonin treating, compared with LPS-induced A549 cells (P < 0.01). wogonin 74-81 C-C motif chemokine ligand 2 Homo sapiens 22-26 35562953-10 2022 In addition, the pharmacological beta-catenin inhibitor MSAB reduces active beta-catenin, downregulates the expression of associated genes and alters CCL2 secretion. methyl 3-(((4-methylphenyl)sulfonyl)amino)benzoate 56-60 C-C motif chemokine ligand 2 Homo sapiens 150-154 35464092-13 2022 Finally, CCL2, FOS, JUN were manifested a meaningful association with proteinuria, glomerular filtration rate (GFR), and serum creatinine level. Creatinine 127-137 C-C motif chemokine ligand 2 Homo sapiens 9-13 35498406-0 2022 Vitamin D Reduces Thyroid Cancer Cells Migration Independently From the Modulation of CCL2 and CXCL8 Chemokines Secretion. Vitamin D 0-9 C-C motif chemokine ligand 2 Homo sapiens 86-90 35498406-5 2022 The aim of the present study was to investigate if vitamin D could modulate both thyroid cancer cell migration and their ability to secrete CCL2 and CXCL8. Vitamin D 51-60 C-C motif chemokine ligand 2 Homo sapiens 140-144 35498406-9 2022 Vitamin D differently modulated the secretion of CCL2 and CXCL8, by significantly inhibiting the secretion of CCL2 in both thyroid cancer cell lines and inhibiting the secretion of CXCL8 only in TPC-1 (ANOVAs p < 0.05). Vitamin D 0-9 C-C motif chemokine ligand 2 Homo sapiens 49-53 35498406-9 2022 Vitamin D differently modulated the secretion of CCL2 and CXCL8, by significantly inhibiting the secretion of CCL2 in both thyroid cancer cell lines and inhibiting the secretion of CXCL8 only in TPC-1 (ANOVAs p < 0.05). Vitamin D 0-9 C-C motif chemokine ligand 2 Homo sapiens 110-114 35498406-11 2022 Future studies specifically designed at clarifying the pathways involved in the different inhibitory effects of vitamin D on CCL2 and CXCL8 in thyroid cancer cells appear worthwhile. Vitamin D 112-121 C-C motif chemokine ligand 2 Homo sapiens 125-129 35400331-8 2022 RESULTS: Excess sucrose significantly enhanced inflammatory signal molecules (e.g., IL-1beta, IL-6, CCL2) secretion, concomitant with the enhancement of intracellular triglycerides in co-cultured HepG2 cells. Sucrose 16-23 C-C motif chemokine ligand 2 Homo sapiens 100-104 35400331-8 2022 RESULTS: Excess sucrose significantly enhanced inflammatory signal molecules (e.g., IL-1beta, IL-6, CCL2) secretion, concomitant with the enhancement of intracellular triglycerides in co-cultured HepG2 cells. Triglycerides 167-180 C-C motif chemokine ligand 2 Homo sapiens 100-104 35022322-8 2022 CCL2 and IL-10 induction was also observed in serum of recurrent GBM patients treated with oHSV (rQnestin34.5) (NCT03152318). ohsv 91-95 C-C motif chemokine ligand 2 Homo sapiens 0-4 35530963-9 2022 Results: 100 nmol/L Celastrol can significantly inhibit LPS-induced inflammatory responses and down-regulate the expression levels of cytokines such as inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX2), tumor necrosis factor-alpha (TNF-alpha), chemokines (CCL-2, and CXCL-10), as well as chemokines. celastrol 20-29 C-C motif chemokine ligand 2 Homo sapiens 270-275 35441585-7 2022 It also suppressed the expression of pro-inflammatory mediators, interleukin-6 (IL-6) and monocyte chemokine protein 1 (MCP-1), against high glucose exposure in hGECs. Glucose 141-148 C-C motif chemokine ligand 2 Homo sapiens 90-118 35441585-7 2022 It also suppressed the expression of pro-inflammatory mediators, interleukin-6 (IL-6) and monocyte chemokine protein 1 (MCP-1), against high glucose exposure in hGECs. Glucose 141-148 C-C motif chemokine ligand 2 Homo sapiens 120-125 35301059-10 2022 Moreover, we found that cadmium exposure induces the pro-inflammatory state of the adipocytes by enhancing the expression of genes such as IL-6, IL-1B and CCL2, cytokines also induced in obesity. Cadmium 24-31 C-C motif chemokine ligand 2 Homo sapiens 155-159 35064409-5 2022 Compared with normal-glucose treatment, the expression of microRNA-155 markedly increased in HRGECs treated with high-glucose, as well as the mRNA and protein levels of ETS-1, VCAM-1, MCP-1 and cleaved caspase-3. Glucose 118-125 C-C motif chemokine ligand 2 Homo sapiens 184-189 35363774-8 2022 Moreover, CDH2 and MCP-1 mRNAs inversely correlated with creatinine (r = -0.370 and r = -0.361, p<0.001) and Alb/Cr ratio (r = -0.355 and r = -0.297, p<0.001). Creatinine 57-67 C-C motif chemokine ligand 2 Homo sapiens 19-24 35363774-8 2022 Moreover, CDH2 and MCP-1 mRNAs inversely correlated with creatinine (r = -0.370 and r = -0.361, p<0.001) and Alb/Cr ratio (r = -0.355 and r = -0.297, p<0.001). Chromium 113-115 C-C motif chemokine ligand 2 Homo sapiens 19-24 35372072-11 2022 Network pharmacological results showed that the active ingredient luteolin, quercetin, licochalcone a, and kaempferol and the effective targets prostaglandin-endoperoxide synthase 2 (PTGS2), matrix metallopeptidase 9 (MMP9), and C-C motif chemokine ligand 2 (CCL2) were related to the interleukin-17 (IL-17) and tumor necrosis factor (TNF) pathway. Quercetin 76-85 C-C motif chemokine ligand 2 Homo sapiens 229-257 35369030-9 2022 Furthermore, CL alone increases the secretion of monocyte chemoattractant protein (MCP)-1 by astrocytic cells, which is blocked by the TLR 4-specific antagonist TAK-242. ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate 161-168 C-C motif chemokine ligand 2 Homo sapiens 49-89 35372072-11 2022 Network pharmacological results showed that the active ingredient luteolin, quercetin, licochalcone a, and kaempferol and the effective targets prostaglandin-endoperoxide synthase 2 (PTGS2), matrix metallopeptidase 9 (MMP9), and C-C motif chemokine ligand 2 (CCL2) were related to the interleukin-17 (IL-17) and tumor necrosis factor (TNF) pathway. kaempferol 107-117 C-C motif chemokine ligand 2 Homo sapiens 229-257 35372072-13 2022 The results showed that luteolin and quercetin increased the expression of PTGS2 and MMP9 and reduced the expression of CCL2 in HaCaT cells treated with gefitinib. Quercetin 37-46 C-C motif chemokine ligand 2 Homo sapiens 120-124 35372072-13 2022 The results showed that luteolin and quercetin increased the expression of PTGS2 and MMP9 and reduced the expression of CCL2 in HaCaT cells treated with gefitinib. Gefitinib 153-162 C-C motif chemokine ligand 2 Homo sapiens 120-124 35372072-15 2022 Luteolin and quercetin may be the core active ingredients of QYSLS in the treatment of EGFRI-related adverse skin reactions, and their therapeutic effects are potentially mediated through PTGS2, CCL2, and MMP9 in the IL-17 and TNF signaling pathway. Luteolin 0-8 C-C motif chemokine ligand 2 Homo sapiens 195-199 35372072-15 2022 Luteolin and quercetin may be the core active ingredients of QYSLS in the treatment of EGFRI-related adverse skin reactions, and their therapeutic effects are potentially mediated through PTGS2, CCL2, and MMP9 in the IL-17 and TNF signaling pathway. Quercetin 13-22 C-C motif chemokine ligand 2 Homo sapiens 195-199 35372072-11 2022 Network pharmacological results showed that the active ingredient luteolin, quercetin, licochalcone a, and kaempferol and the effective targets prostaglandin-endoperoxide synthase 2 (PTGS2), matrix metallopeptidase 9 (MMP9), and C-C motif chemokine ligand 2 (CCL2) were related to the interleukin-17 (IL-17) and tumor necrosis factor (TNF) pathway. licochalcone A 87-101 C-C motif chemokine ligand 2 Homo sapiens 229-257 35268019-3 2022 We previously demonstrated that Korean red ginseng extract (RGE) decreases H. pylori-induced increases in ROS and monocyte chemoattractant protein 1 in gastric epithelial cells. (2s)-2-Amino-5-(2-(Methylsulfinyl)acetimidamido)pentanoic Acid 60-63 C-C motif chemokine ligand 2 Homo sapiens 114-148 35350779-6 2022 Two metabolic analysis methods, including Compass, showed that glycolysis, fatty acid metabolism, bile acid synthesis and purine and pyrimidine metabolism levels of CCL2+ T cells, Group 2 macrophages and myeloid dendritic cells were upregulated and correlated with cytokine storms of COVID-19 patients. Fatty Acids 75-85 C-C motif chemokine ligand 2 Homo sapiens 165-169 35350779-6 2022 Two metabolic analysis methods, including Compass, showed that glycolysis, fatty acid metabolism, bile acid synthesis and purine and pyrimidine metabolism levels of CCL2+ T cells, Group 2 macrophages and myeloid dendritic cells were upregulated and correlated with cytokine storms of COVID-19 patients. Bile Acids and Salts 98-107 C-C motif chemokine ligand 2 Homo sapiens 165-169 35350779-6 2022 Two metabolic analysis methods, including Compass, showed that glycolysis, fatty acid metabolism, bile acid synthesis and purine and pyrimidine metabolism levels of CCL2+ T cells, Group 2 macrophages and myeloid dendritic cells were upregulated and correlated with cytokine storms of COVID-19 patients. purine 122-128 C-C motif chemokine ligand 2 Homo sapiens 165-169 35255173-7 2022 Then, the selected compound (diene 1) was evaluated as to its ability to inhibit the secretion of pro-inflammatory cytokines (IL-1beta, TNF-alpha, INF-gamma, MCP-1, and IL-6) and increase the production of anti-inflammatory cytokines (IL-13, IL-4, and IL-10). diene 29-34 C-C motif chemokine ligand 2 Homo sapiens 158-163 35402580-4 2022 Five hub ARGs (CCL2, AMBRA1, VEGFA, MYC and EGFR) were obtained using a multivariate Cox regression model. args 9-13 C-C motif chemokine ligand 2 Homo sapiens 15-19 35246487-10 2022 CSF-1 in serum and urine, and calprotectin in saliva and urine, as well as TNF- alpha, IP-10 and MCP-1 in urine correlated positively with measures of general DA (p<0.05). da 159-161 C-C motif chemokine ligand 2 Homo sapiens 97-102 35350779-6 2022 Two metabolic analysis methods, including Compass, showed that glycolysis, fatty acid metabolism, bile acid synthesis and purine and pyrimidine metabolism levels of CCL2+ T cells, Group 2 macrophages and myeloid dendritic cells were upregulated and correlated with cytokine storms of COVID-19 patients. pyrimidine 133-143 C-C motif chemokine ligand 2 Homo sapiens 165-169 35239010-9 2022 Significant changes (p < 0.05 versus baseline) were observed in the expression of IL-6, IP-10, MCP-1, and CD54 following the administration of fluocinolone acetonide implant. Fluocinolone Acetonide 143-165 C-C motif chemokine ligand 2 Homo sapiens 95-100 35121342-9 2022 Pre-stimulation of HUVECs with 25-OHC decreased endothelial cell integrity (p < 0.001) and increased the expression of IL-33, ICAM-1, MCP-1, VEGF, TNF-alpha mRNA (p < 0.01) compared to unstimulated controls. 25-hydroxycholesterol 31-37 C-C motif chemokine ligand 2 Homo sapiens 134-139 35196657-3 2022 OBJECTIVE: This study aims to explore the relationship of MCP1 protein expression in induced sputum with Th2 inflammation and asthma clinical features. th2 105-108 C-C motif chemokine ligand 2 Homo sapiens 58-62 35218410-7 2022 CCL2, 5, and 7 known as the elements of the senescence-associated secretory phenotype (SASP) which is a secretome including proinflammatory cytokines and chemokines emitted by senescent cells and a representative feature of senescence, were upregulated by H2O2 treatment or Padi2 knockdown. Hydrogen Peroxide 256-260 C-C motif chemokine ligand 2 Homo sapiens 0-4 35196657-4 2022 METHODS: MCP1 protein expression in induced sputum and serum was detected by ELISA in patients with asthma, and its correlation with Th2 inflammation and lung function was analyzed. th2 133-136 C-C motif chemokine ligand 2 Homo sapiens 9-13 35164829-13 2022 Lastly, adalimumab, baricitinib, and tofacitinib treatment were able to attenuate the pembrolizumab-induced MCP-1 production (P = 0.0004, P = 0.033, and P = 0.025, respectively), while this was not seen with tocilizumab treatment (P = 0.75). baricitinib 20-31 C-C motif chemokine ligand 2 Homo sapiens 108-113 35265066-5 2022 We also demonstrated that addition of CDDO-Me to tri-cultures enhanced T cell-mediated reductions in CCL2, VEGF and IL-6 production in a contact-independent manner. bardoxolone methyl 38-45 C-C motif chemokine ligand 2 Homo sapiens 101-105 35129359-0 2022 C7N6/Sc2CCl2 Weak van der Waals Heterostructure: A Promising Visible-Light-Driven Z-Scheme Water Splitting Photocatalyst with Interface Ultrafast Carrier Recombination. Water 91-96 C-C motif chemokine ligand 2 Homo sapiens 8-12 35129359-2 2022 Here, based on extensive first-principles calculations combined with excited state dynamics simulations, we report that a weak van der Waals (vdW) C7N6/Sc2CCl2 heterostructure is a mediator-free direct Z-scheme photocatalyst for solar water splitting. Water 235-240 C-C motif chemokine ligand 2 Homo sapiens 155-159 34982964-12 2022 As expected, the esters were able to inhibit TNF-alpha and MCP-1 significantly in PBMCs (P < 0.005). Esters 17-23 C-C motif chemokine ligand 2 Homo sapiens 59-64 34982964-13 2022 Especially, javamide-I ester inhibited TNF-alpha, MCP-1, IL-1beta and IL-8 with IC50 values of 1.79, 0.88, 0.91 and 2.57 muM in PBMCs. javamide-i ester 12-28 C-C motif chemokine ligand 2 Homo sapiens 50-55 35164829-13 2022 Lastly, adalimumab, baricitinib, and tofacitinib treatment were able to attenuate the pembrolizumab-induced MCP-1 production (P = 0.0004, P = 0.033, and P = 0.025, respectively), while this was not seen with tocilizumab treatment (P = 0.75). tofacitinib 37-48 C-C motif chemokine ligand 2 Homo sapiens 108-113 35204788-8 2022 However, ibuprofen (25 microg/mL for 3 days) significantly decreased mean secretion of: CCL2 (by 44%), HGF (by 31%), IL-6 (by 22%), VEGF (by 20%) and IL-4 (by 8%) compared to secretion of control MSCs (p < 0.05). Ibuprofen 9-18 C-C motif chemokine ligand 2 Homo sapiens 88-92 35062054-6 2022 The cumulative evidence synthesized in the current review suggests that, traditional therapies which include thiazolidinediones, statins and some calcium channel blockers can be useful in the primary prevention of atherosclerosis by inhibiting the formation of monocyte-derived microparticles, and pro-inflammatory cytokines such as IL-6, TNF-alpha, MCP-1, and NF-kappaB in patients with T2D. Thiazolidinediones 109-127 C-C motif chemokine ligand 2 Homo sapiens 350-355 35135448-9 2022 Molecular docking and dynamics simulations were performed to study the interaction between selected target genes (Chemokine ligand 2 (CCL2) and matrix metalloproteinase 1 (MMP1)) and active ingredients (quercetin and wogonin) of Ermiao San. Quercetin 203-212 C-C motif chemokine ligand 2 Homo sapiens 134-138 35135448-9 2022 Molecular docking and dynamics simulations were performed to study the interaction between selected target genes (Chemokine ligand 2 (CCL2) and matrix metalloproteinase 1 (MMP1)) and active ingredients (quercetin and wogonin) of Ermiao San. wogonin 217-224 C-C motif chemokine ligand 2 Homo sapiens 134-138 35135448-11 2022 CCL2 and MMP1 were identified and verified to be the targets of both quercetin and wogonin, the two active ingredients of Ermiao San, by molecular docking and molecular dynamics. Quercetin 69-78 C-C motif chemokine ligand 2 Homo sapiens 0-4 35135448-11 2022 CCL2 and MMP1 were identified and verified to be the targets of both quercetin and wogonin, the two active ingredients of Ermiao San, by molecular docking and molecular dynamics. wogonin 83-90 C-C motif chemokine ligand 2 Homo sapiens 0-4 35094658-7 2022 IL-1beta-induced high secretion levels of nitric oxide and prostaglandin 2, TNF-alpha, IL-6 and MCP-1 were down-regulated by TB-II treatment, indicating an anti-inflammatory effect of TB-II on OA in vitro condition. timosaponin B-II 125-130 C-C motif chemokine ligand 2 Homo sapiens 96-101 35094658-7 2022 IL-1beta-induced high secretion levels of nitric oxide and prostaglandin 2, TNF-alpha, IL-6 and MCP-1 were down-regulated by TB-II treatment, indicating an anti-inflammatory effect of TB-II on OA in vitro condition. timosaponin B-II 184-189 C-C motif chemokine ligand 2 Homo sapiens 96-101 35062054-6 2022 The cumulative evidence synthesized in the current review suggests that, traditional therapies which include thiazolidinediones, statins and some calcium channel blockers can be useful in the primary prevention of atherosclerosis by inhibiting the formation of monocyte-derived microparticles, and pro-inflammatory cytokines such as IL-6, TNF-alpha, MCP-1, and NF-kappaB in patients with T2D. Calcium 146-153 C-C motif chemokine ligand 2 Homo sapiens 350-355 35498891-13 2022 The urinary monocyte chemoattractant protein-1:creatinine ratio decreased numerically 30% by week 8, possibly reflecting the anti-inflammatory activity of avacopan. avacopan 155-163 C-C motif chemokine ligand 2 Homo sapiens 12-46 35059772-8 2022 RESULTS: In the present study, we found that DHA significantly suppressed AngII-induced proliferation of VSMCs and the expression of IL-6 and Ccl2 in a dose-dependent manner. artenimol 45-48 C-C motif chemokine ligand 2 Homo sapiens 142-146 34818666-4 2022 IVSK reduced the secretion of inflammatory mediators, interleukin (IL)-8 and monocyte chemoattractant protein-1 (MCP-1) and the mRNA expression of IL-6, IL-8, MCP-1 and IL-1beta. ivsk 0-4 C-C motif chemokine ligand 2 Homo sapiens 77-111 35164046-6 2022 In addition, the inhibitory effects of both doses of MiodesinTM (10 microg/mL and 200 microg/mL) resulted in reduced secretion of interleukin-1beta (IL-1beta), IL-6, IL-8, tumor necrosis factor alpha (TNF-alpha) (24 h, 48 h, and 72 h) and CCL2, CCL3, and CLL5 (p < 0.05) by VK2 E6/E7 cells. miodesintm 53-63 C-C motif chemokine ligand 2 Homo sapiens 239-243 35164046-7 2022 In the same way, COX-1 MiodesinTM inhibited LPS-induced hyperactivation of KLE cells, as demonstrated by reduced secretion of IL-1beta, IL-6, IL-8, TNF-alpha (24 h, 48 h, and 72 h) and CCL2, CCL3, and CLL5 (p < 0.05). miodesintm 23-33 C-C motif chemokine ligand 2 Homo sapiens 185-189 34913455-5 2022 However, the detection of Cl atoms is of limited value, because in the pyrolysis CCl2 is formed as a side product, which in turn dissociates to CCl + Cl. Cefaclor 144-147 C-C motif chemokine ligand 2 Homo sapiens 81-85 35011106-8 2022 Curcumin significantly reduced plasma pro-inflammatory mediators (CCL-2, IFN-gamma, and IL-4) and lipid peroxidation. Curcumin 0-8 C-C motif chemokine ligand 2 Homo sapiens 66-71 35276782-7 2022 LPS and indoxyl sulfate demonstrated co-toxicity to endothelial cells inducing reactive oxygen species, E-selectin, and monocyte chemoattractant protein-1 (MCP-1) production. Indican 8-23 C-C motif chemokine ligand 2 Homo sapiens 120-154 35276782-7 2022 LPS and indoxyl sulfate demonstrated co-toxicity to endothelial cells inducing reactive oxygen species, E-selectin, and monocyte chemoattractant protein-1 (MCP-1) production. Indican 8-23 C-C motif chemokine ligand 2 Homo sapiens 156-161 34913455-7 2022 A comparison of the CCl images with control experiments on CCl2 suggest that the dissociation to CCl + Cl2 contributes to the photochemistry of CCl3. Cefaclor 97-100 C-C motif chemokine ligand 2 Homo sapiens 59-63 34983149-8 2022 Levels of serum Hcy, ICAM-1 and MCP-1 in patients with mild, moderate and severe DME were significantly different (all p <0.001). dme 81-84 C-C motif chemokine ligand 2 Homo sapiens 32-37 35000531-7 2022 Meanwhile, CCL2 down-regulating significantly repressed the proliferation, migration, and invasion by regulating miR-128. mir-128 113-120 C-C motif chemokine ligand 2 Homo sapiens 11-15 35000531-8 2022 In addition, we proved miR-128 was a direct target of CCL2 through double luciferase assay and bioinformatics analysis. mir-128 23-30 C-C motif chemokine ligand 2 Homo sapiens 54-58 35000531-10 2022 More importantly, miR-128 could reverse the effects of lncRNA CCL2 knocked down. mir-128 18-25 C-C motif chemokine ligand 2 Homo sapiens 62-66 34983149-11 2022 CONCLUSION: Levels of serum Hcy, ICAM-1 and MCP-1 in patients with DR complicated with DME were higher than those without visual disability; and levels of Hcy, ICAM-1 and MCP-1 in patients with visual disability were higher than those without visual disability. dme 87-90 C-C motif chemokine ligand 2 Homo sapiens 44-49 35012414-1 2021 NADPH oxidase (Nox) 4 produces H2O2 by forming a heterodimer with p22phox and is involved in hemangioendothelioma development through monocyte chemoattractant protein-1 (MCP-1) upregulation. Hydrogen Peroxide 31-35 C-C motif chemokine ligand 2 Homo sapiens 134-168 35024638-7 2022 COBMINDEX was accompanied by changes in inflammatory markers that coincided with changes in cortisol: changes in serum levels of cortisol correlated positively with those of IL-10 and IFNalpha and negatively with those of MCP-1. cobmindex 0-9 C-C motif chemokine ligand 2 Homo sapiens 222-227 35024638-7 2022 COBMINDEX was accompanied by changes in inflammatory markers that coincided with changes in cortisol: changes in serum levels of cortisol correlated positively with those of IL-10 and IFNalpha and negatively with those of MCP-1. Hydrocortisone 129-137 C-C motif chemokine ligand 2 Homo sapiens 222-227 35012414-1 2021 NADPH oxidase (Nox) 4 produces H2O2 by forming a heterodimer with p22phox and is involved in hemangioendothelioma development through monocyte chemoattractant protein-1 (MCP-1) upregulation. Hydrogen Peroxide 31-35 C-C motif chemokine ligand 2 Homo sapiens 170-175