PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
2680808-1	1989	Classic homocystinuria is an autosomal recessive metabolic disease due to a cystathionine-beta-synthase deficiency with consequent blocking of homocysteine and serine condensation for producing cystathionine.	Homocysteine	143-155	cystathionine beta-synthase	Homo sapiens	76-103
2620270-3	1989	As to the effect of the four McAbs on platelet aggregation, the results showed: 1) HIP4 and HIP8 can completely inhibit platelet aggregation induced by ADP or collagen, but not that induced by thrombin or ristocetin.	Adenosine Diphosphate	152-155	cystathionine beta-synthase	Homo sapiens	83-87
2680808-1	1989	Classic homocystinuria is an autosomal recessive metabolic disease due to a cystathionine-beta-synthase deficiency with consequent blocking of homocysteine and serine condensation for producing cystathionine.	Serine	160-166	cystathionine beta-synthase	Homo sapiens	76-103
3305117-1	1987	De-Nol (colloidal bismuth subcitrate, CBS) precipitates in an acid environment and adheres to the exudate layer covering an ulcer crater; moreover, CBS blocks pepsin activity, retards hydrogen-ion back-diffusion and stimulates prostaglandin synthesis.	Bismuth	18-25	cystathionine beta-synthase	Homo sapiens	148-151
3305117-1	1987	De-Nol (colloidal bismuth subcitrate, CBS) precipitates in an acid environment and adheres to the exudate layer covering an ulcer crater; moreover, CBS blocks pepsin activity, retards hydrogen-ion back-diffusion and stimulates prostaglandin synthesis.	Hydrogen	184-192	cystathionine beta-synthase	Homo sapiens	148-151
3305117-1	1987	De-Nol (colloidal bismuth subcitrate, CBS) precipitates in an acid environment and adheres to the exudate layer covering an ulcer crater; moreover, CBS blocks pepsin activity, retards hydrogen-ion back-diffusion and stimulates prostaglandin synthesis.	Prostaglandins	227-240	cystathionine beta-synthase	Homo sapiens	38-41
3305117-1	1987	De-Nol (colloidal bismuth subcitrate, CBS) precipitates in an acid environment and adheres to the exudate layer covering an ulcer crater; moreover, CBS blocks pepsin activity, retards hydrogen-ion back-diffusion and stimulates prostaglandin synthesis.	Prostaglandins	227-240	cystathionine beta-synthase	Homo sapiens	148-151
7447458-0	1980	Depletion of cultured human fibroblasts of pyridoxal 5"-phosphate: effect on activities of aspartate aminotransferase, alanine aminotransferase, and cystathionine beta-synthase.	Pyridoxal Phosphate	43-65	cystathionine beta-synthase	Homo sapiens	149-176
3091098-5	1986	We also measured the activities of another three enzymes of the folic acid cycle, viz., 5,10-methylene-H4folate dehydrogenase, 10-formyl-H4folate synthetase, and 5,10-methenyl-H4folate cyclohydrolase, as well as the enzyme cystathionine beta-synthase.	Folic Acid	64-74	cystathionine beta-synthase	Homo sapiens	223-250
3457373-10	1986	Cystathionine beta-synthase clones were obtained by screening the library with a single-stranded [32P]cDNA prepared directly from the highly purified synthase mRNA by reverse transcriptase.	Phosphorus-32	98-101	cystathionine beta-synthase	Homo sapiens	0-27
3080869-7	1986	Serum levels of Met and Hcy strongly suggest that the first step of the transsulfuration pathway is impaired in protein-depleted states due to cystathionine beta-synthase (EC 4.2.1.22) deficiency.	Homocystine	24-27	cystathionine beta-synthase	Homo sapiens	143-170
6838228-4	1983	253, 6523-6528) for the purification of cystathionine beta-synthase [L-serine hydro-lyase (adding homocysteine) EC 4.2.1.22], a pyridoxal 5"-phosphate-dependent enzyme from human liver has been modified.	Homocysteine	98-110	cystathionine beta-synthase	Homo sapiens	40-67
6838228-4	1983	253, 6523-6528) for the purification of cystathionine beta-synthase [L-serine hydro-lyase (adding homocysteine) EC 4.2.1.22], a pyridoxal 5"-phosphate-dependent enzyme from human liver has been modified.	Pyridoxal Phosphate	128-150	cystathionine beta-synthase	Homo sapiens	40-67
6785521-3	1981	However, in one pyridoxine responsive case the level of cystathionine beta-synthase activity was found to be comparable with those of the heterozygotes.	Pyridoxine	16-26	cystathionine beta-synthase	Homo sapiens	56-83
6785524-2	1981	Cystathionine beta-synthase activity was stimulated in all four homocystinuric cell strains at 486 mu mol/l; aspartate and alanine aminotransferase activity was also increased, particularly in the pyridoxine responsive cell strains.	Pyridoxine	197-207	cystathionine beta-synthase	Homo sapiens	0-27
6706952-1	1984	A single specific radiolabeled polypeptide with an apparent Mr = 63,000 was recovered when cystathionine beta-synthase (EC 4.2.1.22) was precipitated from extracts of radiolabeled cultured human fibroblasts with an antiserum raised against pure human liver synthase, and the immunocomplexes were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	Sodium Dodecyl Sulfate	308-330	cystathionine beta-synthase	Homo sapiens	91-118
6706952-1	1984	A single specific radiolabeled polypeptide with an apparent Mr = 63,000 was recovered when cystathionine beta-synthase (EC 4.2.1.22) was precipitated from extracts of radiolabeled cultured human fibroblasts with an antiserum raised against pure human liver synthase, and the immunocomplexes were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.	polyacrylamide	331-345	cystathionine beta-synthase	Homo sapiens	91-118
681363-2	1978	Cystathionine beta-synthase has been purified from human liver more than 3000-fold by a series of steps including high speed centrifugation, ammonium sulfate fractionation, chromatography on hydroxylapatite and DEAE-cellulose, gel filtration, preparative polyacrylamide gel electrophoresis, and glycerol density gradient centrifugation.	Ammonium Sulfate	141-157	cystathionine beta-synthase	Homo sapiens	0-27
7400312-0	1980	Affinity of cystathionine beta-synthase for pyridoxal 5"-phosphate in cultured cells.	Pyridoxal Phosphate	44-66	cystathionine beta-synthase	Homo sapiens	12-39
7400312-5	1980	Under these conditions, intracellular pyridoxal 5"-phosphate fell by >95%, and saturation of cystathionine beta-synthase apoenzyme with pyridoxal 5"-phosphate decreased from a predepletion value of 70% to <10%.	Pyridoxal Phosphate	139-161	cystathionine beta-synthase	Homo sapiens	96-123
7400312-9	1980	Estimates of the affinity of control and mutant cystathionine beta-synthase for pyridoxal 5"-phosphate in cell extracts supported the differences observed in intact cells.	Pyridoxal Phosphate	80-102	cystathionine beta-synthase	Homo sapiens	48-75
7400312-10	1980	The apparent K(m) of cystathionine beta-synthase for pyridoxal 5"-phosphate in extracts of depleted cells from four in vivo-responsive patients was two to four times that of control.	Pyridoxal Phosphate	53-75	cystathionine beta-synthase	Homo sapiens	21-48
7400312-12	1980	These results suggest that cystathionine beta-synthase activity in cells from patients containing a mutant enzyme with a moderately reduced affinity for pyridoxal 5"-phosphate can be increased by pyridoxine supplements in vivo, whereas that from patients whose enzyme has a more dramatically reduced affinity for the coenzyme cannot be so modulated because of limits on the capacity of such cells to accumulate and retain pyridoxal 5"-phosphate.	Pyridoxal Phosphate	153-175	cystathionine beta-synthase	Homo sapiens	27-54
7400312-12	1980	These results suggest that cystathionine beta-synthase activity in cells from patients containing a mutant enzyme with a moderately reduced affinity for pyridoxal 5"-phosphate can be increased by pyridoxine supplements in vivo, whereas that from patients whose enzyme has a more dramatically reduced affinity for the coenzyme cannot be so modulated because of limits on the capacity of such cells to accumulate and retain pyridoxal 5"-phosphate.	Pyridoxine	196-206	cystathionine beta-synthase	Homo sapiens	27-54
7400312-12	1980	These results suggest that cystathionine beta-synthase activity in cells from patients containing a mutant enzyme with a moderately reduced affinity for pyridoxal 5"-phosphate can be increased by pyridoxine supplements in vivo, whereas that from patients whose enzyme has a more dramatically reduced affinity for the coenzyme cannot be so modulated because of limits on the capacity of such cells to accumulate and retain pyridoxal 5"-phosphate.	Pyridoxal Phosphate	422-444	cystathionine beta-synthase	Homo sapiens	27-54
681363-2	1978	Cystathionine beta-synthase has been purified from human liver more than 3000-fold by a series of steps including high speed centrifugation, ammonium sulfate fractionation, chromatography on hydroxylapatite and DEAE-cellulose, gel filtration, preparative polyacrylamide gel electrophoresis, and glycerol density gradient centrifugation.	Durapatite	191-206	cystathionine beta-synthase	Homo sapiens	0-27
681363-2	1978	Cystathionine beta-synthase has been purified from human liver more than 3000-fold by a series of steps including high speed centrifugation, ammonium sulfate fractionation, chromatography on hydroxylapatite and DEAE-cellulose, gel filtration, preparative polyacrylamide gel electrophoresis, and glycerol density gradient centrifugation.	DEAE-Cellulose	211-225	cystathionine beta-synthase	Homo sapiens	0-27
681363-2	1978	Cystathionine beta-synthase has been purified from human liver more than 3000-fold by a series of steps including high speed centrifugation, ammonium sulfate fractionation, chromatography on hydroxylapatite and DEAE-cellulose, gel filtration, preparative polyacrylamide gel electrophoresis, and glycerol density gradient centrifugation.	polyacrylamide	255-269	cystathionine beta-synthase	Homo sapiens	0-27
681363-2	1978	Cystathionine beta-synthase has been purified from human liver more than 3000-fold by a series of steps including high speed centrifugation, ammonium sulfate fractionation, chromatography on hydroxylapatite and DEAE-cellulose, gel filtration, preparative polyacrylamide gel electrophoresis, and glycerol density gradient centrifugation.	Glycerol	295-303	cystathionine beta-synthase	Homo sapiens	0-27
4531018-3	1974	Cystathionine beta-synthase [L-serine hydrolyase (adding homocysteine), EC 4.2.1.22] was studied in cultured skin fibroblasts from two control subjects and three patients with pyridoxine-responsive homocystinuria.	Homocysteine	57-69	cystathionine beta-synthase	Homo sapiens	0-27
732830-0	1978	Cystathionine beta-synthase deficiency: observations on the biochemical lesion in a vitamin B6 non-responsive patient.	Vitamin B 6	84-94	cystathionine beta-synthase	Homo sapiens	0-27
404147-10	1977	It has been concluded that the molecular defect in the case of pyridoxine non-responsive homocystinuria examined in the present investigation arises as a result of an alteration in the structural gene which codes for the lower molecular weight sub-unit of cystathionine beta-synthase.	Pyridoxine	63-73	cystathionine beta-synthase	Homo sapiens	256-283
641146-5	1978	Two of these lines showed a five- and sevenfold stimulation of cystathionine beta-synthase activity with added pyridoxal-5"-phosphate; in the other four, the cofactor addition increased activity only modestly, as in controls.	Pyridoxal Phosphate	111-133	cystathionine beta-synthase	Homo sapiens	63-90
641146-10	1978	We conclude that at least three general classes of cystathionine beta-synthase mutants exist: those with no residual activity; those with reduced activity and normal affinity for pyridoxal-5" phosphate; and those with reduced activity and a reduced affinity for the cofactor.	Pyridoxal Phosphate	179-201	cystathionine beta-synthase	Homo sapiens	51-78
4531018-3	1974	Cystathionine beta-synthase [L-serine hydrolyase (adding homocysteine), EC 4.2.1.22] was studied in cultured skin fibroblasts from two control subjects and three patients with pyridoxine-responsive homocystinuria.	Pyridoxine	176-186	cystathionine beta-synthase	Homo sapiens	0-27
32800520-2	2021	CBS gene KD in ASC52telo cells led to increased cellular inflammation (IL6, CXCL8, TNF) and oxidative stress markers (increased intracellular reactive oxygen species and decreased reduced glutathione levels) in parallel to decreased H2S production and rejuvenation (LC3 and SIRT1)-related gene expression.	reactive	142-150	cystathionine beta-synthase	Homo sapiens	0-3
32800520-2	2021	CBS gene KD in ASC52telo cells led to increased cellular inflammation (IL6, CXCL8, TNF) and oxidative stress markers (increased intracellular reactive oxygen species and decreased reduced glutathione levels) in parallel to decreased H2S production and rejuvenation (LC3 and SIRT1)-related gene expression.	oxygen species	151-165	cystathionine beta-synthase	Homo sapiens	0-3
34050373-6	2021	Alternatively, an acquired inhibition of cystathionine-beta-synthase which is important for homocysteine metabolism could explain the plasma homocysteine increase.	Homocysteine	92-104	cystathionine beta-synthase	Homo sapiens	41-68
34050373-6	2021	Alternatively, an acquired inhibition of cystathionine-beta-synthase which is important for homocysteine metabolism could explain the plasma homocysteine increase.	Homocysteine	141-153	cystathionine beta-synthase	Homo sapiens	41-68
32800520-2	2021	CBS gene KD in ASC52telo cells led to increased cellular inflammation (IL6, CXCL8, TNF) and oxidative stress markers (increased intracellular reactive oxygen species and decreased reduced glutathione levels) in parallel to decreased H2S production and rejuvenation (LC3 and SIRT1)-related gene expression.	Glutathione	188-199	cystathionine beta-synthase	Homo sapiens	0-3
32800520-2	2021	CBS gene KD in ASC52telo cells led to increased cellular inflammation (IL6, CXCL8, TNF) and oxidative stress markers (increased intracellular reactive oxygen species and decreased reduced glutathione levels) in parallel to decreased H2S production and rejuvenation (LC3 and SIRT1)-related gene expression.	Deuterium	233-236	cystathionine beta-synthase	Homo sapiens	0-3
33295057-0	2021	Cystathionine beta-synthase deficiency in the E-HOD registry-Part I: pyridoxine responsiveness as a determinant of biochemical and clinical phenotype at diagnosis.	Pyridoxine	69-79	cystathionine beta-synthase	Homo sapiens	0-27
33964857-2	2021	The plasma concentration of homocysteine is dependent on the activities of several B vitamin-dependent enzymes, such as methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and cystathionine beta-synthase (CBS).	Homocysteine	28-40	cystathionine beta-synthase	Homo sapiens	234-261
33964857-2	2021	The plasma concentration of homocysteine is dependent on the activities of several B vitamin-dependent enzymes, such as methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and cystathionine beta-synthase (CBS).	Homocysteine	28-40	cystathionine beta-synthase	Homo sapiens	263-266
33985475-3	2021	He was diagnosed with CBS deficiency according to a high level of serum homocysteine and compound heterozygous mutations at two different positions on the CBS gene.	Homocysteine	72-84	cystathionine beta-synthase	Homo sapiens	22-25
33713531-0	2021	H2 S catalysed by CBS regulates testosterone synthesis through affecting the sulfhydrylation of PDE.	Deuterium	0-4	cystathionine beta-synthase	Homo sapiens	18-21
33861472-9	2021	Screening of amino acids in plasma by liquid-chromatography showed co-increased levels of methionine (median 71 mumol/L; range 23-616; normal < 40), suggestive of acquired deficiency of cystathionine-beta-synthase.	Methionine	90-100	cystathionine beta-synthase	Homo sapiens	186-213
32865440-1	2021	PURPOSE: Deficiency in Cystathionine beta-synthase (CBS) leads to an abnormal accumulation of homocysteine and results in classical homocystinuria, a multi-systemic disorder that affects connective tissue, muscles, the central nervous system and the eyes.	Homocysteine	94-106	cystathionine beta-synthase	Homo sapiens	52-55
33713531-0	2021	H2 S catalysed by CBS regulates testosterone synthesis through affecting the sulfhydrylation of PDE.	Testosterone	32-44	cystathionine beta-synthase	Homo sapiens	18-21
33713531-7	2021	The relative mRNA and protein expression of CBS, PDE4A, PDE8A and proteins related to testosterone synthesis were detected by RT-qPCR and western blotting.	Testosterone	86-98	cystathionine beta-synthase	Homo sapiens	44-47
33724098-6	2021	Genetic factors may link B vitamins with stroke severity due to the impact on Hcy metabolism of polymorphism in the genes coding for methylenetetrahydrofolate reductase, methionine-synthase, methionine synthase reductase, and cystathionine beta-synthase.	Homocysteine	78-81	cystathionine beta-synthase	Homo sapiens	226-253
33868930-14	2021	Further studies are needed to identify the effects of different intensities and modes of exercise in larger cohorts of CBS patients with different levels of pyridoxine responsiveness.	Pyridoxine	157-167	cystathionine beta-synthase	Homo sapiens	119-122
33719952-2	2021	BACKGROUND: The protein coded by cystathionine beta synthase (CBS) gene act as a catalyzer, converts homocysteine to cystathionine.	Homocysteine	101-113	cystathionine beta-synthase	Homo sapiens	33-60
33714972-10	2021	Serum phosphorus levels, alkaline phosphatase, hemoglobin, and triglycerides were found to be closely associated with CBS and CSE scores in femur tissues.	Phosphorus	6-16	cystathionine beta-synthase	Homo sapiens	118-121
33714972-10	2021	Serum phosphorus levels, alkaline phosphatase, hemoglobin, and triglycerides were found to be closely associated with CBS and CSE scores in femur tissues.	Triglycerides	63-76	cystathionine beta-synthase	Homo sapiens	118-121
33719952-2	2021	BACKGROUND: The protein coded by cystathionine beta synthase (CBS) gene act as a catalyzer, converts homocysteine to cystathionine.	Homocysteine	101-113	cystathionine beta-synthase	Homo sapiens	62-65
33719952-2	2021	BACKGROUND: The protein coded by cystathionine beta synthase (CBS) gene act as a catalyzer, converts homocysteine to cystathionine.	Cystathionine	33-46	cystathionine beta-synthase	Homo sapiens	62-65
33558454-1	2021	Increased endogenous hydrogen sulfide (H2S) level by cystathionine beta-synthase (CBS) has been shown to closely relate tumorigenesis.	Hydrogen Sulfide	21-37	cystathionine beta-synthase	Homo sapiens	53-80
33484818-2	2021	The enzymes responsible for the biological generation of H2S include cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST).	Deuterium	57-60	cystathionine beta-synthase	Homo sapiens	69-96
33484818-2	2021	The enzymes responsible for the biological generation of H2S include cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST).	Deuterium	57-60	cystathionine beta-synthase	Homo sapiens	98-101
33558454-1	2021	Increased endogenous hydrogen sulfide (H2S) level by cystathionine beta-synthase (CBS) has been shown to closely relate tumorigenesis.	Hydrogen Sulfide	21-37	cystathionine beta-synthase	Homo sapiens	82-85
33558454-1	2021	Increased endogenous hydrogen sulfide (H2S) level by cystathionine beta-synthase (CBS) has been shown to closely relate tumorigenesis.	Deuterium	39-42	cystathionine beta-synthase	Homo sapiens	53-80
33558454-1	2021	Increased endogenous hydrogen sulfide (H2S) level by cystathionine beta-synthase (CBS) has been shown to closely relate tumorigenesis.	Deuterium	39-42	cystathionine beta-synthase	Homo sapiens	82-85
33558454-6	2021	The knockdown of CBS expression by shRNA and inhibiting CBS activity by AOAA decreased the endogenous H2S levels, promoted mitochondrial-related apoptosis and inhibited the NF-kappaB-mediated gene expression.	Deuterium	102-105	cystathionine beta-synthase	Homo sapiens	17-20
33558454-6	2021	The knockdown of CBS expression by shRNA and inhibiting CBS activity by AOAA decreased the endogenous H2S levels, promoted mitochondrial-related apoptosis and inhibited the NF-kappaB-mediated gene expression.	Deuterium	102-105	cystathionine beta-synthase	Homo sapiens	56-59
33521459-0	2021	Heme-Thiolate Perturbation in Cystathionine beta-Synthase by Mercury Compounds.	heme-thiolate	0-13	cystathionine beta-synthase	Homo sapiens	30-57
33499368-3	2021	Cystathionine -lyase (CSE), cystathionine beta-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST) are currently viewed as the principal mammalian H2S-generating enzymes.	Deuterium	159-162	cystathionine beta-synthase	Homo sapiens	28-55
33499368-3	2021	Cystathionine -lyase (CSE), cystathionine beta-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST) are currently viewed as the principal mammalian H2S-generating enzymes.	Deuterium	159-162	cystathionine beta-synthase	Homo sapiens	57-60
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Sulfur	59-65	cystathionine beta-synthase	Homo sapiens	29-32
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Pyridoxal Phosphate	96-115	cystathionine beta-synthase	Homo sapiens	0-27
33521459-0	2021	Heme-Thiolate Perturbation in Cystathionine beta-Synthase by Mercury Compounds.	Mercury	61-68	cystathionine beta-synthase	Homo sapiens	30-57
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Pyridoxal Phosphate	96-115	cystathionine beta-synthase	Homo sapiens	29-32
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Homocysteine	142-154	cystathionine beta-synthase	Homo sapiens	0-27
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Homocysteine	142-154	cystathionine beta-synthase	Homo sapiens	29-32
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Serine	160-166	cystathionine beta-synthase	Homo sapiens	0-27
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Sulfur	59-65	cystathionine beta-synthase	Homo sapiens	0-27
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Serine	160-166	cystathionine beta-synthase	Homo sapiens	29-32
33179842-0	2021	CBS and MAT2A improve methionine-mediated DNA synthesis through SAMTOR/mTORC1/S6K1/CAD pathway during embryo implantation.	Methionine	22-32	cystathionine beta-synthase	Homo sapiens	0-3
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Cysteine	146-154	cystathionine beta-synthase	Homo sapiens	0-27
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Cysteine	146-154	cystathionine beta-synthase	Homo sapiens	29-32
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Cystathionine	187-200	cystathionine beta-synthase	Homo sapiens	0-27
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Cystathionine	187-200	cystathionine beta-synthase	Homo sapiens	29-32
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Water	205-210	cystathionine beta-synthase	Homo sapiens	0-27
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Water	205-210	cystathionine beta-synthase	Homo sapiens	29-32
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Hydrogen Sulfide	214-230	cystathionine beta-synthase	Homo sapiens	0-27
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Hydrogen Sulfide	214-230	cystathionine beta-synthase	Homo sapiens	29-32
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Deuterium	232-235	cystathionine beta-synthase	Homo sapiens	0-27
33521459-1	2021	Cystathionine beta-synthase (CBS) is an enzyme involved in sulfur metabolism that catalyzes the pyridoxal phosphate-dependent condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Deuterium	232-235	cystathionine beta-synthase	Homo sapiens	29-32
33521459-2	2021	CBS possesses a b-type heme coordinated by histidine and cysteine.	Heme	23-27	cystathionine beta-synthase	Homo sapiens	0-3
33521459-2	2021	CBS possesses a b-type heme coordinated by histidine and cysteine.	Histidine	43-52	cystathionine beta-synthase	Homo sapiens	0-3
33521459-2	2021	CBS possesses a b-type heme coordinated by histidine and cysteine.	Cysteine	57-65	cystathionine beta-synthase	Homo sapiens	0-3
33521459-3	2021	Fe(III)-CBS is inert toward exogenous ligands, while Fe(II)-CBS is reactive.	ferric sulfate	0-7	cystathionine beta-synthase	Homo sapiens	8-11
33521459-3	2021	Fe(III)-CBS is inert toward exogenous ligands, while Fe(II)-CBS is reactive.	ammonium ferrous sulfate	53-59	cystathionine beta-synthase	Homo sapiens	60-63
33521459-4	2021	Both Fe(III)- and Fe(II)-CBS are sensitive to mercury compounds.	ammonium ferrous sulfate	18-24	cystathionine beta-synthase	Homo sapiens	25-28
33521459-4	2021	Both Fe(III)- and Fe(II)-CBS are sensitive to mercury compounds.	Mercury	46-53	cystathionine beta-synthase	Homo sapiens	25-28
33521459-8	2021	The reactions of Fe(II)-CBS were faster than those of Fe(III)-CBS.	ammonium ferrous sulfate	17-23	cystathionine beta-synthase	Homo sapiens	24-27
33521459-8	2021	The reactions of Fe(II)-CBS were faster than those of Fe(III)-CBS.	ammonium ferrous sulfate	17-23	cystathionine beta-synthase	Homo sapiens	62-65
33521459-8	2021	The reactions of Fe(II)-CBS were faster than those of Fe(III)-CBS.	ferric sulfate	54-61	cystathionine beta-synthase	Homo sapiens	24-27
33521459-8	2021	The reactions of Fe(II)-CBS were faster than those of Fe(III)-CBS.	ferric sulfate	54-61	cystathionine beta-synthase	Homo sapiens	62-65
33521459-9	2021	The observed rate constants of the first phase increased hyperbolically with concentration of the mercury compounds, with limiting values of 0.3-0.4 s-1 for Fe(III)-CBS and 40 +- 4 s-1 for Fe(II)-CBS.	Mercury	98-105	cystathionine beta-synthase	Homo sapiens	165-168
33521459-9	2021	The observed rate constants of the first phase increased hyperbolically with concentration of the mercury compounds, with limiting values of 0.3-0.4 s-1 for Fe(III)-CBS and 40 +- 4 s-1 for Fe(II)-CBS.	Mercury	98-105	cystathionine beta-synthase	Homo sapiens	196-199
33521459-9	2021	The observed rate constants of the first phase increased hyperbolically with concentration of the mercury compounds, with limiting values of 0.3-0.4 s-1 for Fe(III)-CBS and 40 +- 4 s-1 for Fe(II)-CBS.	ferric sulfate	157-164	cystathionine beta-synthase	Homo sapiens	165-168
33521459-9	2021	The observed rate constants of the first phase increased hyperbolically with concentration of the mercury compounds, with limiting values of 0.3-0.4 s-1 for Fe(III)-CBS and 40 +- 4 s-1 for Fe(II)-CBS.	ammonium ferrous sulfate	189-195	cystathionine beta-synthase	Homo sapiens	196-199
33521459-11	2021	Exposure of Fe(III)-CBS to HgCl2 led to heme release and activity loss.	ferric sulfate	12-19	cystathionine beta-synthase	Homo sapiens	20-23
33521459-11	2021	Exposure of Fe(III)-CBS to HgCl2 led to heme release and activity loss.	Mercuric Chloride	27-32	cystathionine beta-synthase	Homo sapiens	20-23
33521459-11	2021	Exposure of Fe(III)-CBS to HgCl2 led to heme release and activity loss.	Heme	40-44	cystathionine beta-synthase	Homo sapiens	20-23
33521459-12	2021	Our study reveals the complexity of the interactions between mercury compounds and CBS.	Mercury	61-68	cystathionine beta-synthase	Homo sapiens	83-86
33179842-6	2021	We showed that methionine deprivation sharply decreased embryo implantation sites, expression of CBS and transsulfuration pathway end products, which were reversed by maternal methionine supplementation during early pregnancy.	Methionine	15-25	cystathionine beta-synthase	Homo sapiens	97-100
33179842-6	2021	We showed that methionine deprivation sharply decreased embryo implantation sites, expression of CBS and transsulfuration pathway end products, which were reversed by maternal methionine supplementation during early pregnancy.	Methionine	176-186	cystathionine beta-synthase	Homo sapiens	97-100
33179842-7	2021	Moreover, we found CBS improved methionine-mediated cell proliferation and DNA synthesis by CBS inhibition or interference.	Methionine	32-42	cystathionine beta-synthase	Homo sapiens	19-22
33179842-7	2021	Moreover, we found CBS improved methionine-mediated cell proliferation and DNA synthesis by CBS inhibition or interference.	Methionine	32-42	cystathionine beta-synthase	Homo sapiens	92-95
33179842-10	2021	CONCLUSIONS: Taken together, these studies demonstrate that CBS and MAT2A improve methionine-mediated DNA synthesis through SAMTOR/mTORC1/S6K1/CAD pathway during embryo implantation.	Methionine	82-92	cystathionine beta-synthase	Homo sapiens	60-63
33035509-0	2020	Mechanism of cystathionine-beta-synthase inhibition by disulfiram: The role of bis(N,N-diethyldithiocarbamate)-copper(II).	Disulfiram	55-65	cystathionine beta-synthase	Homo sapiens	13-40
33035509-0	2020	Mechanism of cystathionine-beta-synthase inhibition by disulfiram: The role of bis(N,N-diethyldithiocarbamate)-copper(II).	bis(n,n-diethyldithiocarbamate)	79-110	cystathionine beta-synthase	Homo sapiens	13-40
33035509-0	2020	Mechanism of cystathionine-beta-synthase inhibition by disulfiram: The role of bis(N,N-diethyldithiocarbamate)-copper(II).	cupric ion	111-121	cystathionine beta-synthase	Homo sapiens	13-40
33035509-3	2020	A recent yeast screen suggested that disulfiram (a well-known inhibitor of aldehyde dehydrogenase and a clinically used drug in the treatment of alcoholism) may inhibit CBS in a cell-based environment.	Disulfiram	37-47	cystathionine beta-synthase	Homo sapiens	169-172
33035509-3	2020	A recent yeast screen suggested that disulfiram (a well-known inhibitor of aldehyde dehydrogenase and a clinically used drug in the treatment of alcoholism) may inhibit CBS in a cell-based environment.	Aldehydes	75-83	cystathionine beta-synthase	Homo sapiens	169-172
33035509-5	2020	We investigated the potential role of bioconversion of disulfiram to bis(N,N-diethyldithiocarbamate)-copper(II) complex (CuDDC) in the inhibitory effect of disulfiram on H2S production and assessed its effect in two human cell types with high CBS expression: HCT116 colon cancer cells and Down syndrome (DS) fibroblasts.	Disulfiram	55-65	cystathionine beta-synthase	Homo sapiens	243-246
33035509-6	2020	METHODS: H2S production from recombinant human CBS, CSE and 3-MST was measured using the fluorescent H2S probe AzMC.	Deuterium	9-12	cystathionine beta-synthase	Homo sapiens	47-50
33035509-6	2020	METHODS: H2S production from recombinant human CBS, CSE and 3-MST was measured using the fluorescent H2S probe AzMC.	Deuterium	101-104	cystathionine beta-synthase	Homo sapiens	47-50
33035509-6	2020	METHODS: H2S production from recombinant human CBS, CSE and 3-MST was measured using the fluorescent H2S probe AzMC.	azmc	111-115	cystathionine beta-synthase	Homo sapiens	47-50
33035509-17	2020	CuDDC inhibited H2S production in both cell types studied and exerted the functional effects that would be expected from a CBS inhibitor: inhibition of cell proliferation of cancer cells and a bell-shaped effect (stimulation of proliferation at low concentration and inhibition of these responses at higher concentration) in DS cells.	cuddc	0-5	cystathionine beta-synthase	Homo sapiens	123-126
33035509-19	2020	CONCLUSIONS: Disulfiram, via its metabolite CuDDC acts as an inhibitor of CBS and a scavenger of H2S, which, in turn, potently suppresses H2S levels in various cell types.	Disulfiram	13-23	cystathionine beta-synthase	Homo sapiens	74-77
33035509-19	2020	CONCLUSIONS: Disulfiram, via its metabolite CuDDC acts as an inhibitor of CBS and a scavenger of H2S, which, in turn, potently suppresses H2S levels in various cell types.	cuddc	44-49	cystathionine beta-synthase	Homo sapiens	74-77
32542668-2	2020	Endogenous H2 S is produced mainly by three endogenous enzymes: cystathionine beta-synthase, cystathionine gamma-lyase, and 3-mercaptopyruvate sulfur transferase.	Deuterium	11-15	cystathionine beta-synthase	Homo sapiens	64-91
32860803-3	2020	Our main objective was to investigate whether the aminooxyacetic acid (AOAA) and DL-Propargylglycine (PAG), two specific inhibitors of CBS and CSE, could assist DIM to play a stronger anti-cancer effects in gastric cancer BGC-823 and SGC-7901 cells.	Aminooxyacetic Acid	71-75	cystathionine beta-synthase	Homo sapiens	135-138
33262405-1	2020	Cystathionine beta-synthase (CBS) is a eukaryotic enzyme that maintains the cellular homocysteine homeostasis and catalyzes the conversion of homocysteine to L-cystathionine and Hydrogen sulfide, via the trans-sulfuration pathway.	Homocysteine	85-97	cystathionine beta-synthase	Homo sapiens	29-32
33262405-1	2020	Cystathionine beta-synthase (CBS) is a eukaryotic enzyme that maintains the cellular homocysteine homeostasis and catalyzes the conversion of homocysteine to L-cystathionine and Hydrogen sulfide, via the trans-sulfuration pathway.	Homocysteine	142-154	cystathionine beta-synthase	Homo sapiens	29-32
33262405-1	2020	Cystathionine beta-synthase (CBS) is a eukaryotic enzyme that maintains the cellular homocysteine homeostasis and catalyzes the conversion of homocysteine to L-cystathionine and Hydrogen sulfide, via the trans-sulfuration pathway.	Cystathionine	158-173	cystathionine beta-synthase	Homo sapiens	29-32
33262405-1	2020	Cystathionine beta-synthase (CBS) is a eukaryotic enzyme that maintains the cellular homocysteine homeostasis and catalyzes the conversion of homocysteine to L-cystathionine and Hydrogen sulfide, via the trans-sulfuration pathway.	Hydrogen Sulfide	178-194	cystathionine beta-synthase	Homo sapiens	29-32
32975579-6	2020	This increase of SQOR induces the downregulation of the cystathionine beta-synthase and cystathionine gamma-lyase, two enzymes of the transsulfuration pathway, the subsequent downregulation of serine biosynthesis and the adaptation of other sulfide linked pathways, such as folate cycle, nucleotides metabolism and glutathione system.	Folic Acid	274-280	cystathionine beta-synthase	Homo sapiens	56-83
32975579-6	2020	This increase of SQOR induces the downregulation of the cystathionine beta-synthase and cystathionine gamma-lyase, two enzymes of the transsulfuration pathway, the subsequent downregulation of serine biosynthesis and the adaptation of other sulfide linked pathways, such as folate cycle, nucleotides metabolism and glutathione system.	Glutathione	315-326	cystathionine beta-synthase	Homo sapiens	56-83
32860803-2	2020	Hydrogen sulfide (H2S) plays an important role in the tumor development and therapy, cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE), two key endogenous H2S biosynthesis enzymes, can affect endogenous H2S levels and alter cancer treatment.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	85-112
32860803-2	2020	Hydrogen sulfide (H2S) plays an important role in the tumor development and therapy, cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE), two key endogenous H2S biosynthesis enzymes, can affect endogenous H2S levels and alter cancer treatment.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	114-117
32860803-2	2020	Hydrogen sulfide (H2S) plays an important role in the tumor development and therapy, cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE), two key endogenous H2S biosynthesis enzymes, can affect endogenous H2S levels and alter cancer treatment.	Deuterium	18-21	cystathionine beta-synthase	Homo sapiens	85-112
32506120-2	2020	Synthesized by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), hydrogen sulfide (H2S) promotes regulatory T-cell differentiation and regulates immune hemostasis; yet, its role in URSA is elusive.	Hydrogen Sulfide	86-102	cystathionine beta-synthase	Homo sapiens	15-42
32506120-2	2020	Synthesized by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), hydrogen sulfide (H2S) promotes regulatory T-cell differentiation and regulates immune hemostasis; yet, its role in URSA is elusive.	Hydrogen Sulfide	86-102	cystathionine beta-synthase	Homo sapiens	44-47
32506120-2	2020	Synthesized by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), hydrogen sulfide (H2S) promotes regulatory T-cell differentiation and regulates immune hemostasis; yet, its role in URSA is elusive.	Deuterium	104-107	cystathionine beta-synthase	Homo sapiens	15-42
32506120-2	2020	Synthesized by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), hydrogen sulfide (H2S) promotes regulatory T-cell differentiation and regulates immune hemostasis; yet, its role in URSA is elusive.	Deuterium	104-107	cystathionine beta-synthase	Homo sapiens	44-47
32975579-6	2020	This increase of SQOR induces the downregulation of the cystathionine beta-synthase and cystathionine gamma-lyase, two enzymes of the transsulfuration pathway, the subsequent downregulation of serine biosynthesis and the adaptation of other sulfide linked pathways, such as folate cycle, nucleotides metabolism and glutathione system.	Serine	193-199	cystathionine beta-synthase	Homo sapiens	56-83
32975579-6	2020	This increase of SQOR induces the downregulation of the cystathionine beta-synthase and cystathionine gamma-lyase, two enzymes of the transsulfuration pathway, the subsequent downregulation of serine biosynthesis and the adaptation of other sulfide linked pathways, such as folate cycle, nucleotides metabolism and glutathione system.	Sulfides	241-248	cystathionine beta-synthase	Homo sapiens	56-83
32768567-2	2020	Cystathionine beta-synthase (CBS) is a housekeeping enzyme that catalyzes the first step in metabolic conversion of homocysteine (Hcy) to cysteine.	Homocysteine	116-128	cystathionine beta-synthase	Homo sapiens	0-27
32768567-2	2020	Cystathionine beta-synthase (CBS) is a housekeeping enzyme that catalyzes the first step in metabolic conversion of homocysteine (Hcy) to cysteine.	Homocysteine	116-128	cystathionine beta-synthase	Homo sapiens	29-32
32768567-2	2020	Cystathionine beta-synthase (CBS) is a housekeeping enzyme that catalyzes the first step in metabolic conversion of homocysteine (Hcy) to cysteine.	Homocysteine	130-133	cystathionine beta-synthase	Homo sapiens	0-27
32768567-2	2020	Cystathionine beta-synthase (CBS) is a housekeeping enzyme that catalyzes the first step in metabolic conversion of homocysteine (Hcy) to cysteine.	Homocysteine	130-133	cystathionine beta-synthase	Homo sapiens	29-32
32768567-2	2020	Cystathionine beta-synthase (CBS) is a housekeeping enzyme that catalyzes the first step in metabolic conversion of homocysteine (Hcy) to cysteine.	Cysteine	120-128	cystathionine beta-synthase	Homo sapiens	0-27
32768567-2	2020	Cystathionine beta-synthase (CBS) is a housekeeping enzyme that catalyzes the first step in metabolic conversion of homocysteine (Hcy) to cysteine.	Cysteine	120-128	cystathionine beta-synthase	Homo sapiens	29-32
33282308-9	2020	Conclusion: There is an association between fasting and post-oral methionine load plasma Hcy concentrations with the allelic frequencies of the polymorphisms C669T, 844ins68, and C1080T of the cystathionine beta-synthase and C667T of the methylenetetrahydrofolate reductase in healthy Mexican individuals.	Methionine	66-76	cystathionine beta-synthase	Homo sapiens	193-220
33282308-9	2020	Conclusion: There is an association between fasting and post-oral methionine load plasma Hcy concentrations with the allelic frequencies of the polymorphisms C669T, 844ins68, and C1080T of the cystathionine beta-synthase and C667T of the methylenetetrahydrofolate reductase in healthy Mexican individuals.	Homocysteine	89-92	cystathionine beta-synthase	Homo sapiens	193-220
32860803-2	2020	Hydrogen sulfide (H2S) plays an important role in the tumor development and therapy, cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE), two key endogenous H2S biosynthesis enzymes, can affect endogenous H2S levels and alter cancer treatment.	Deuterium	18-21	cystathionine beta-synthase	Homo sapiens	114-117
32860803-2	2020	Hydrogen sulfide (H2S) plays an important role in the tumor development and therapy, cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE), two key endogenous H2S biosynthesis enzymes, can affect endogenous H2S levels and alter cancer treatment.	Deuterium	175-178	cystathionine beta-synthase	Homo sapiens	85-112
32860803-2	2020	Hydrogen sulfide (H2S) plays an important role in the tumor development and therapy, cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE), two key endogenous H2S biosynthesis enzymes, can affect endogenous H2S levels and alter cancer treatment.	Deuterium	175-178	cystathionine beta-synthase	Homo sapiens	114-117
32860803-2	2020	Hydrogen sulfide (H2S) plays an important role in the tumor development and therapy, cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE), two key endogenous H2S biosynthesis enzymes, can affect endogenous H2S levels and alter cancer treatment.	Deuterium	175-178	cystathionine beta-synthase	Homo sapiens	85-112
32860803-2	2020	Hydrogen sulfide (H2S) plays an important role in the tumor development and therapy, cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE), two key endogenous H2S biosynthesis enzymes, can affect endogenous H2S levels and alter cancer treatment.	Deuterium	175-178	cystathionine beta-synthase	Homo sapiens	114-117
32860803-3	2020	Our main objective was to investigate whether the aminooxyacetic acid (AOAA) and DL-Propargylglycine (PAG), two specific inhibitors of CBS and CSE, could assist DIM to play a stronger anti-cancer effects in gastric cancer BGC-823 and SGC-7901 cells.	Aminooxyacetic Acid	50-69	cystathionine beta-synthase	Homo sapiens	135-138
32860803-3	2020	Our main objective was to investigate whether the aminooxyacetic acid (AOAA) and DL-Propargylglycine (PAG), two specific inhibitors of CBS and CSE, could assist DIM to play a stronger anti-cancer effects in gastric cancer BGC-823 and SGC-7901 cells.	DL-Propargylglycine	81-100	cystathionine beta-synthase	Homo sapiens	135-138
32860803-3	2020	Our main objective was to investigate whether the aminooxyacetic acid (AOAA) and DL-Propargylglycine (PAG), two specific inhibitors of CBS and CSE, could assist DIM to play a stronger anti-cancer effects in gastric cancer BGC-823 and SGC-7901 cells.	pag	102-105	cystathionine beta-synthase	Homo sapiens	135-138
33179601-4	2020	The trans-sulphuration reaction depends on the enzyme cystathionine beta synthase and its cofactor vitamin B6.	Vitamin B 6	99-109	cystathionine beta-synthase	Homo sapiens	54-81
32987401-6	2020	Estradiol-17beta (E2) (but not progesterone) stimulated CBS (but not CSE) expression and H2S production in pPRM endometrial stromal cells (ESCs) in vitro, which were attenuated by ICI 182 780.	Estradiol	0-16	cystathionine beta-synthase	Homo sapiens	56-59
32987401-6	2020	Estradiol-17beta (E2) (but not progesterone) stimulated CBS (but not CSE) expression and H2S production in pPRM endometrial stromal cells (ESCs) in vitro, which were attenuated by ICI 182 780.	Estradiol	18-20	cystathionine beta-synthase	Homo sapiens	56-59
32820583-1	2020	Classic homocystinuria is due to deficiency of cystathionine beta-synthase (CBS), a pyridoxine-dependent enzyme that, depending on the molecular variants, may be co-factor responsive.	Pyridoxine	84-94	cystathionine beta-synthase	Homo sapiens	47-74
32820583-1	2020	Classic homocystinuria is due to deficiency of cystathionine beta-synthase (CBS), a pyridoxine-dependent enzyme that, depending on the molecular variants, may be co-factor responsive.	Pyridoxine	84-94	cystathionine beta-synthase	Homo sapiens	76-79
32987401-0	2020	Enhanced Stromal Cell CBS-H2S Production Promotes Estrogen-Stimulated Human Endometrial Angiogenesis.	Deuterium	26-29	cystathionine beta-synthase	Homo sapiens	22-25
32987401-2	2020	Endogenous hydrogen sulfide (H2S), produced by cystathionine-beta synthase (CBS) and cystathionine-gamma lyase (CSE), is a potent proangiogenic factor; yet, whether the H2S system is expressed in the endometrium and whether H2S plays a role in endometrial angiogenesis are unknown.	Hydrogen Sulfide	11-27	cystathionine beta-synthase	Homo sapiens	47-74
32987401-2	2020	Endogenous hydrogen sulfide (H2S), produced by cystathionine-beta synthase (CBS) and cystathionine-gamma lyase (CSE), is a potent proangiogenic factor; yet, whether the H2S system is expressed in the endometrium and whether H2S plays a role in endometrial angiogenesis are unknown.	Hydrogen Sulfide	11-27	cystathionine beta-synthase	Homo sapiens	76-79
32987401-2	2020	Endogenous hydrogen sulfide (H2S), produced by cystathionine-beta synthase (CBS) and cystathionine-gamma lyase (CSE), is a potent proangiogenic factor; yet, whether the H2S system is expressed in the endometrium and whether H2S plays a role in endometrial angiogenesis are unknown.	Deuterium	29-32	cystathionine beta-synthase	Homo sapiens	47-74
32987401-2	2020	Endogenous hydrogen sulfide (H2S), produced by cystathionine-beta synthase (CBS) and cystathionine-gamma lyase (CSE), is a potent proangiogenic factor; yet, whether the H2S system is expressed in the endometrium and whether H2S plays a role in endometrial angiogenesis are unknown.	Deuterium	29-32	cystathionine beta-synthase	Homo sapiens	76-79
32987401-2	2020	Endogenous hydrogen sulfide (H2S), produced by cystathionine-beta synthase (CBS) and cystathionine-gamma lyase (CSE), is a potent proangiogenic factor; yet, whether the H2S system is expressed in the endometrium and whether H2S plays a role in endometrial angiogenesis are unknown.	Deuterium	169-172	cystathionine beta-synthase	Homo sapiens	76-79
32987401-2	2020	Endogenous hydrogen sulfide (H2S), produced by cystathionine-beta synthase (CBS) and cystathionine-gamma lyase (CSE), is a potent proangiogenic factor; yet, whether the H2S system is expressed in the endometrium and whether H2S plays a role in endometrial angiogenesis are unknown.	Deuterium	169-172	cystathionine beta-synthase	Homo sapiens	76-79
32417499-3	2020	Three enzymes, cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE), and 3-mercaptopyruvate-sulfurtransferase (MPST), are mainly responsible for H2S production.	Deuterium	159-162	cystathionine beta-synthase	Homo sapiens	15-42
33000151-2	2020	The further metabolism of Hcy by the transsulfuration pathway is facilitated by activation of cystathionine beta-synthase (CBS) by S-adenosylmethionine (SAM) as well as the relatively high KM of CBS for Hcy.	Homocysteine	26-29	cystathionine beta-synthase	Homo sapiens	94-121
33000151-2	2020	The further metabolism of Hcy by the transsulfuration pathway is facilitated by activation of cystathionine beta-synthase (CBS) by S-adenosylmethionine (SAM) as well as the relatively high KM of CBS for Hcy.	Homocysteine	26-29	cystathionine beta-synthase	Homo sapiens	123-126
33000151-2	2020	The further metabolism of Hcy by the transsulfuration pathway is facilitated by activation of cystathionine beta-synthase (CBS) by S-adenosylmethionine (SAM) as well as the relatively high KM of CBS for Hcy.	Homocysteine	26-29	cystathionine beta-synthase	Homo sapiens	195-198
33000151-2	2020	The further metabolism of Hcy by the transsulfuration pathway is facilitated by activation of cystathionine beta-synthase (CBS) by S-adenosylmethionine (SAM) as well as the relatively high KM of CBS for Hcy.	S-Adenosylmethionine	131-151	cystathionine beta-synthase	Homo sapiens	94-121
33000151-2	2020	The further metabolism of Hcy by the transsulfuration pathway is facilitated by activation of cystathionine beta-synthase (CBS) by S-adenosylmethionine (SAM) as well as the relatively high KM of CBS for Hcy.	S-Adenosylmethionine	131-151	cystathionine beta-synthase	Homo sapiens	123-126
33000151-2	2020	The further metabolism of Hcy by the transsulfuration pathway is facilitated by activation of cystathionine beta-synthase (CBS) by S-adenosylmethionine (SAM) as well as the relatively high KM of CBS for Hcy.	S-Adenosylmethionine	153-156	cystathionine beta-synthase	Homo sapiens	94-121
33000151-2	2020	The further metabolism of Hcy by the transsulfuration pathway is facilitated by activation of cystathionine beta-synthase (CBS) by S-adenosylmethionine (SAM) as well as the relatively high KM of CBS for Hcy.	S-Adenosylmethionine	153-156	cystathionine beta-synthase	Homo sapiens	123-126
33000151-2	2020	The further metabolism of Hcy by the transsulfuration pathway is facilitated by activation of cystathionine beta-synthase (CBS) by S-adenosylmethionine (SAM) as well as the relatively high KM of CBS for Hcy.	Homocysteine	203-206	cystathionine beta-synthase	Homo sapiens	123-126
33000151-2	2020	The further metabolism of Hcy by the transsulfuration pathway is facilitated by activation of cystathionine beta-synthase (CBS) by S-adenosylmethionine (SAM) as well as the relatively high KM of CBS for Hcy.	Homocysteine	203-206	cystathionine beta-synthase	Homo sapiens	195-198
31983282-7	2020	Taken together, our data suggest that PRKDC-mediated phosphorylation of PRKAG1 primes AMPK complex to the lysosomal activation by STK11 in cancer cells thereby linking DNA damage response to autophagy and cellular metabolism.Abbreviations: AXIN1: axin 1; 3-MA: 3-methyladenine; 5-FU: 5-fluorouracil; AA mutant: double alanine mutant (S192A, T284A) of PRKAG1; ACACA: acetyl-CoA carboxylase alpha; AICAR: 5-Aminoimidazole-4-carboxamide ribonucleotide; AMPK: AMP-activated protein kinase; ATG: autophagy-related; ATM: ataxia telangiectasia mutated; ATR: ATM serine/threonine kinase; AV: autophagic vacuole; AVd: degradative autophagic vacuole; AVi: initial autophagic vacuole; BECN1: beclin 1; BSA: bovine serum albumin; CBS: cystathionine beta-synthase; CDK7: cyclin dependent kinase 7; CDKN1A: cyclin dependent kinase inhibitor 1A; EGFP: enhanced green fluorescent protein; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GST: glutathione S transferase; H2AX/H2AFX: H2A.X variant histone; HBSS: Hanks balanced salt solution; IP: immunopurification; IR: ionizing radiation; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAP3K9: mitogen-activated protein kinase kinase kinase 9; mRFP: monomeric red fluorescent protein; mCh: mCherry; MCM7: minichromosome maintenance complex component 7; MTORC1: mechanistic target of rapamycin kinase complex 1; NHEJ: non-homologous end joining; NRBP2: nuclear receptor binding protein 2; NTC: non-targeting control; NUAK1: NUAK family kinase 1; PBS: phosphate-buffered saline; PIK3AP1: phosphoinositide-3-kinase adaptor protein 1; PIK3CA: phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit alpha; PIKK: phosphatidylinositol 3-kinase-related kinase; PRKAA: protein kinase AMP-activated catalytic subunit alpha; PRKAB: protein kinase AMP-activated non-catalytic subunit beta; PRKAG: protein kinase AMP-activated non-catalytic subunit gamma; PRKDC: protein kinase, DNA-activated, catalytic subunit; RLuc: Renilla luciferase; RPS6KB1: ribosomal protein S6 kinase B1; SQSTM1: sequestosome 1; STK11/LKB1: serine/threonine kinase 11; TP53: tumor protein p53; TSKS: testis specific serine kinase substrate; ULK1: unc-51 like autophagy activating kinase 1; WIPI2: WD repeat domain, phosphoinositide interacting 2; WT: wild type.	Adenosine Monophosphate	86-89	cystathionine beta-synthase	Homo sapiens	723-750
33013017-2	2020	There are three main genes MTHFR, cystathionine beta-synthase (CBS) and methionine synthase (MS) and it"s genetic variant that are known to influence the homocysteine metabolism leading to hyperhomocysteinemia.	Homocysteine	154-166	cystathionine beta-synthase	Homo sapiens	34-61
33013017-2	2020	There are three main genes MTHFR, cystathionine beta-synthase (CBS) and methionine synthase (MS) and it"s genetic variant that are known to influence the homocysteine metabolism leading to hyperhomocysteinemia.	Homocysteine	154-166	cystathionine beta-synthase	Homo sapiens	63-66
31594422-4	2020	SFN is not a H2S donor but it acts via stimulating H2S generation in the brain catalyzed by cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS).	sulforaphane	0-3	cystathionine beta-synthase	Homo sapiens	128-155
31594422-4	2020	SFN is not a H2S donor but it acts via stimulating H2S generation in the brain catalyzed by cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS).	hydrogen sulfite	51-54	cystathionine beta-synthase	Homo sapiens	128-155
32417499-3	2020	Three enzymes, cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE), and 3-mercaptopyruvate-sulfurtransferase (MPST), are mainly responsible for H2S production.	Deuterium	159-162	cystathionine beta-synthase	Homo sapiens	44-47
32997713-2	2020	The Cystathionine-beta-synthase (CBS)-pair domain divalent metal cation transport mediators (CNNMs) have been described to be involved in maintaining Mg2+ homeostasis.	Metals	59-64	cystathionine beta-synthase	Homo sapiens	4-31
32997713-2	2020	The Cystathionine-beta-synthase (CBS)-pair domain divalent metal cation transport mediators (CNNMs) have been described to be involved in maintaining Mg2+ homeostasis.	magnesium ion	150-154	cystathionine beta-synthase	Homo sapiens	4-31
32072237-5	2020	In addition, hyperglycemia-induced activation of the polyol pathway can lead to increased NADH/NAD+ ratio, which might translate into increased levels of hydrogen sulfide-via enhanced activity of cystathionine beta-synthase-that would fuel reductive stress through inhibition of mitochondrial complex I. Reductive stress may be either a potential weapon against cancer priming tumor cells to apoptosis or a cancer"s ally promoting tumor cell proliferation and making tumor cells resistant to reactive oxygen species-inducing drugs.	polyol	53-59	cystathionine beta-synthase	Homo sapiens	196-223
32072237-5	2020	In addition, hyperglycemia-induced activation of the polyol pathway can lead to increased NADH/NAD+ ratio, which might translate into increased levels of hydrogen sulfide-via enhanced activity of cystathionine beta-synthase-that would fuel reductive stress through inhibition of mitochondrial complex I. Reductive stress may be either a potential weapon against cancer priming tumor cells to apoptosis or a cancer"s ally promoting tumor cell proliferation and making tumor cells resistant to reactive oxygen species-inducing drugs.	NAD	90-94	cystathionine beta-synthase	Homo sapiens	196-223
32072237-5	2020	In addition, hyperglycemia-induced activation of the polyol pathway can lead to increased NADH/NAD+ ratio, which might translate into increased levels of hydrogen sulfide-via enhanced activity of cystathionine beta-synthase-that would fuel reductive stress through inhibition of mitochondrial complex I. Reductive stress may be either a potential weapon against cancer priming tumor cells to apoptosis or a cancer"s ally promoting tumor cell proliferation and making tumor cells resistant to reactive oxygen species-inducing drugs.	NAD	95-99	cystathionine beta-synthase	Homo sapiens	196-223
32072237-5	2020	In addition, hyperglycemia-induced activation of the polyol pathway can lead to increased NADH/NAD+ ratio, which might translate into increased levels of hydrogen sulfide-via enhanced activity of cystathionine beta-synthase-that would fuel reductive stress through inhibition of mitochondrial complex I. Reductive stress may be either a potential weapon against cancer priming tumor cells to apoptosis or a cancer"s ally promoting tumor cell proliferation and making tumor cells resistant to reactive oxygen species-inducing drugs.	Hydrogen Sulfide	154-170	cystathionine beta-synthase	Homo sapiens	196-223
32072237-5	2020	In addition, hyperglycemia-induced activation of the polyol pathway can lead to increased NADH/NAD+ ratio, which might translate into increased levels of hydrogen sulfide-via enhanced activity of cystathionine beta-synthase-that would fuel reductive stress through inhibition of mitochondrial complex I. Reductive stress may be either a potential weapon against cancer priming tumor cells to apoptosis or a cancer"s ally promoting tumor cell proliferation and making tumor cells resistant to reactive oxygen species-inducing drugs.	Reactive Oxygen Species	492-515	cystathionine beta-synthase	Homo sapiens	196-223
32487371-3	2020	Interestingly, both heme biosynthesis and sulphur amino acid metabolism require vitamin B6, (Pyridoxal-phosphate, PLP) an important cofactor of ALAS1 and of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) enzymes that catabolize homocysteine (Hcy).	Homocysteine	251-263	cystathionine beta-synthase	Homo sapiens	157-184
32487371-3	2020	Interestingly, both heme biosynthesis and sulphur amino acid metabolism require vitamin B6, (Pyridoxal-phosphate, PLP) an important cofactor of ALAS1 and of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) enzymes that catabolize homocysteine (Hcy).	Homocysteine	251-263	cystathionine beta-synthase	Homo sapiens	186-189
32487371-3	2020	Interestingly, both heme biosynthesis and sulphur amino acid metabolism require vitamin B6, (Pyridoxal-phosphate, PLP) an important cofactor of ALAS1 and of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) enzymes that catabolize homocysteine (Hcy).	Heme	20-24	cystathionine beta-synthase	Homo sapiens	157-184
32487371-3	2020	Interestingly, both heme biosynthesis and sulphur amino acid metabolism require vitamin B6, (Pyridoxal-phosphate, PLP) an important cofactor of ALAS1 and of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) enzymes that catabolize homocysteine (Hcy).	Heme	20-24	cystathionine beta-synthase	Homo sapiens	186-189
32487371-3	2020	Interestingly, both heme biosynthesis and sulphur amino acid metabolism require vitamin B6, (Pyridoxal-phosphate, PLP) an important cofactor of ALAS1 and of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) enzymes that catabolize homocysteine (Hcy).	Vitamin B 6	80-90	cystathionine beta-synthase	Homo sapiens	157-184
32487371-3	2020	Interestingly, both heme biosynthesis and sulphur amino acid metabolism require vitamin B6, (Pyridoxal-phosphate, PLP) an important cofactor of ALAS1 and of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) enzymes that catabolize homocysteine (Hcy).	Vitamin B 6	80-90	cystathionine beta-synthase	Homo sapiens	186-189
32487371-3	2020	Interestingly, both heme biosynthesis and sulphur amino acid metabolism require vitamin B6, (Pyridoxal-phosphate, PLP) an important cofactor of ALAS1 and of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) enzymes that catabolize homocysteine (Hcy).	Pyridoxal Phosphate	93-112	cystathionine beta-synthase	Homo sapiens	157-184
32487371-3	2020	Interestingly, both heme biosynthesis and sulphur amino acid metabolism require vitamin B6, (Pyridoxal-phosphate, PLP) an important cofactor of ALAS1 and of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) enzymes that catabolize homocysteine (Hcy).	Homocysteine	265-268	cystathionine beta-synthase	Homo sapiens	157-184
32487371-3	2020	Interestingly, both heme biosynthesis and sulphur amino acid metabolism require vitamin B6, (Pyridoxal-phosphate, PLP) an important cofactor of ALAS1 and of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) enzymes that catabolize homocysteine (Hcy).	Pyridoxal Phosphate	93-112	cystathionine beta-synthase	Homo sapiens	186-189
32487371-3	2020	Interestingly, both heme biosynthesis and sulphur amino acid metabolism require vitamin B6, (Pyridoxal-phosphate, PLP) an important cofactor of ALAS1 and of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) enzymes that catabolize homocysteine (Hcy).	Homocysteine	265-268	cystathionine beta-synthase	Homo sapiens	186-189
32487371-4	2020	Moreover, heme itself is an important cofactor for CBS.	Heme	10-14	cystathionine beta-synthase	Homo sapiens	51-54
32871814-4	2020	H2S is endogenously produced by three enzymes: Cystathionine gamma-lyase (CSE), cystathionine beta-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (MPST).	Deuterium	0-3	cystathionine beta-synthase	Homo sapiens	80-107
32871814-4	2020	H2S is endogenously produced by three enzymes: Cystathionine gamma-lyase (CSE), cystathionine beta-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (MPST).	Deuterium	0-3	cystathionine beta-synthase	Homo sapiens	109-112
32184133-0	2020	Cysteine becomes conditionally essential during hypobaric hypoxia and regulates adaptive neuro-physiological responses through CBS/H2S pathway.	Cysteine	0-8	cystathionine beta-synthase	Homo sapiens	127-130
31955501-0	2020	The re-emerging pathophysiological role of the cystathionine-beta-synthase - hydrogen sulfide system in Down syndrome.	Hydrogen Sulfide	77-93	cystathionine beta-synthase	Homo sapiens	47-74
31955501-2	2020	Cystathionine-beta-synthase (CBS) is one of the key mammalian enzymes that is responsible for the biological production of the gaseous transmitter hydrogen sulfide (H2 S).	Hydrogen Sulfide	147-163	cystathionine beta-synthase	Homo sapiens	0-27
32515188-2	2020	Dysregulated H2S production from the enzyme system of overexpressed cystathionine beta-synthase has long been considered to act as an autocrine and paracrine factor for the tumor growth and proliferation of colon cancer.	Deuterium	13-16	cystathionine beta-synthase	Homo sapiens	68-95
32532171-0	2021	LncRNA SNHG1 alleviated apoptosis and inflammation during ischemic stroke by targeting miR-376a and modulating CBS/H2S pathway.	Deuterium	115-118	cystathionine beta-synthase	Homo sapiens	111-114
32532171-6	2021	Interaction among lncRNA, miRNA and target gene was validated by luciferase assay.Results: Our research revealed that mRNA level of SNHG1 and CBS in HCMEC/D3 cells was downregulated while miR-376a was upregulated under OGD conditions.	mir-376a	188-196	cystathionine beta-synthase	Homo sapiens	142-145
32532171-9	2021	Moreover, SNHG1 exert its function via inhibiting miR-376a to regulate CBS expression.Conclusion: LncRNA SNHG1 depressed apoptosis and inflammation of IS cell model via inhibiting miR-376a and upregulating CBS/H2S signal.	mir-376a	50-58	cystathionine beta-synthase	Homo sapiens	71-74
32532171-9	2021	Moreover, SNHG1 exert its function via inhibiting miR-376a to regulate CBS expression.Conclusion: LncRNA SNHG1 depressed apoptosis and inflammation of IS cell model via inhibiting miR-376a and upregulating CBS/H2S signal.	mir-376a	50-58	cystathionine beta-synthase	Homo sapiens	206-209
32532171-9	2021	Moreover, SNHG1 exert its function via inhibiting miR-376a to regulate CBS expression.Conclusion: LncRNA SNHG1 depressed apoptosis and inflammation of IS cell model via inhibiting miR-376a and upregulating CBS/H2S signal.	Deuterium	210-213	cystathionine beta-synthase	Homo sapiens	71-74
31955501-2	2020	Cystathionine-beta-synthase (CBS) is one of the key mammalian enzymes that is responsible for the biological production of the gaseous transmitter hydrogen sulfide (H2 S).	Hydrogen Sulfide	147-163	cystathionine beta-synthase	Homo sapiens	29-32
31955501-2	2020	Cystathionine-beta-synthase (CBS) is one of the key mammalian enzymes that is responsible for the biological production of the gaseous transmitter hydrogen sulfide (H2 S).	hydrogen sulfite	165-169	cystathionine beta-synthase	Homo sapiens	0-27
31955501-2	2020	Cystathionine-beta-synthase (CBS) is one of the key mammalian enzymes that is responsible for the biological production of the gaseous transmitter hydrogen sulfide (H2 S).	hydrogen sulfite	165-169	cystathionine beta-synthase	Homo sapiens	29-32
31955501-4	2020	An increased expression of CBS and the consequent overproduction of H2 S is well documented in individuals with DS.	hydrogen sulfite	68-72	cystathionine beta-synthase	Homo sapiens	27-30
32849552-2	2020	Hydrogen sulfide (H2S), a proangiogenic, pro-alveolarization, and anti-asthmatic gasotransmitter is synthesized by cystathionine-gamma-lyase (CSE), cystathionine-beta-synthase (CBS), and 3-mercaptopyruvate sulfur transferase (3MST).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	148-175
32849552-2	2020	Hydrogen sulfide (H2S), a proangiogenic, pro-alveolarization, and anti-asthmatic gasotransmitter is synthesized by cystathionine-gamma-lyase (CSE), cystathionine-beta-synthase (CBS), and 3-mercaptopyruvate sulfur transferase (3MST).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	177-180
32849552-2	2020	Hydrogen sulfide (H2S), a proangiogenic, pro-alveolarization, and anti-asthmatic gasotransmitter is synthesized by cystathionine-gamma-lyase (CSE), cystathionine-beta-synthase (CBS), and 3-mercaptopyruvate sulfur transferase (3MST).	Deuterium	18-21	cystathionine beta-synthase	Homo sapiens	148-175
32849552-2	2020	Hydrogen sulfide (H2S), a proangiogenic, pro-alveolarization, and anti-asthmatic gasotransmitter is synthesized by cystathionine-gamma-lyase (CSE), cystathionine-beta-synthase (CBS), and 3-mercaptopyruvate sulfur transferase (3MST).	Deuterium	18-21	cystathionine beta-synthase	Homo sapiens	177-180
33318876-11	2021	Results: The H2S synthesizing enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), exhibited elevated levels in the clinical samples that correlated with tumor proliferation index.	Deuterium	13-16	cystathionine beta-synthase	Homo sapiens	39-66
33318876-11	2021	Results: The H2S synthesizing enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), exhibited elevated levels in the clinical samples that correlated with tumor proliferation index.	Deuterium	13-16	cystathionine beta-synthase	Homo sapiens	68-71
32184133-8	2020	We, further, present multiple lines of experimental evidence that the limitation of cysteine was causally governed by physiological propensity of brain to utilize cysteine, in cystathionine beta synthase (CBS)-dependent manner, past its endogenous replenishment potential.	Cysteine	84-92	cystathionine beta-synthase	Homo sapiens	176-203
32184133-8	2020	We, further, present multiple lines of experimental evidence that the limitation of cysteine was causally governed by physiological propensity of brain to utilize cysteine, in cystathionine beta synthase (CBS)-dependent manner, past its endogenous replenishment potential.	Cysteine	84-92	cystathionine beta-synthase	Homo sapiens	205-208
32184133-8	2020	We, further, present multiple lines of experimental evidence that the limitation of cysteine was causally governed by physiological propensity of brain to utilize cysteine, in cystathionine beta synthase (CBS)-dependent manner, past its endogenous replenishment potential.	Cysteine	163-171	cystathionine beta-synthase	Homo sapiens	176-203
32184133-8	2020	We, further, present multiple lines of experimental evidence that the limitation of cysteine was causally governed by physiological propensity of brain to utilize cysteine, in cystathionine beta synthase (CBS)-dependent manner, past its endogenous replenishment potential.	Cysteine	163-171	cystathionine beta-synthase	Homo sapiens	205-208
32184133-10	2020	In brief, our data supports an adaptive, physiological role of CBS-mediated cysteine-utilization pathway - activated to increase endogenous levels of H2S - for optimal responses of brain to hypobaric hypoxia.	Cysteine	76-84	cystathionine beta-synthase	Homo sapiens	63-66
32184133-10	2020	In brief, our data supports an adaptive, physiological role of CBS-mediated cysteine-utilization pathway - activated to increase endogenous levels of H2S - for optimal responses of brain to hypobaric hypoxia.	Hydrogen Sulfide	150-153	cystathionine beta-synthase	Homo sapiens	63-66
32463541-2	2020	CBS is the predominant hydrogen sulfide (H2 S)-producing enzyme in endothelial cells (ECs).	Hydrogen Sulfide	23-39	cystathionine beta-synthase	Homo sapiens	0-3
31857119-5	2020	Human CBS is a complex intracellular multimeric enzyme that relies on three cofactors (heme, pyridoxal-5"-phosphate and S-adenosylmethionine) for proper function.	Heme	87-91	cystathionine beta-synthase	Homo sapiens	6-9
32463541-2	2020	CBS is the predominant hydrogen sulfide (H2 S)-producing enzyme in endothelial cells (ECs).	Deuterium	41-45	cystathionine beta-synthase	Homo sapiens	0-3
32463541-7	2020	Mechanistically, CBS silencing significantly elevates ROS production, thereby leading to reduced mitofusin 2 (MFN2) expression, decouple endoplasmic reticulum-mitochondria contacts, increased mitochondria fission, enhanced receptor-mediated mitophagy, and increased EC death.	ros	54-57	cystathionine beta-synthase	Homo sapiens	17-20
32572428-2	2020	Immunohistochemical staining and Western blot were used to detect the localization of the H2S-generating enzymes cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).	Deuterium	90-93	cystathionine beta-synthase	Homo sapiens	113-140
32572428-2	2020	Immunohistochemical staining and Western blot were used to detect the localization of the H2S-generating enzymes cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).	Deuterium	90-93	cystathionine beta-synthase	Homo sapiens	142-145
31857119-5	2020	Human CBS is a complex intracellular multimeric enzyme that relies on three cofactors (heme, pyridoxal-5"-phosphate and S-adenosylmethionine) for proper function.	Pyridoxal Phosphate	93-115	cystathionine beta-synthase	Homo sapiens	6-9
31857119-5	2020	Human CBS is a complex intracellular multimeric enzyme that relies on three cofactors (heme, pyridoxal-5"-phosphate and S-adenosylmethionine) for proper function.	S-Adenosylmethionine	120-140	cystathionine beta-synthase	Homo sapiens	6-9
32477150-4	2020	The cystathionine beta-synthase (CBS), 3-mercaptopyruvate sulfur transferase acts together with cysteine aminotransferase (3-MST/CAT), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfur transferase with D-amino acid oxidase (3-MST/DAO) pathways are involved in the enzymatic production of H2S.	Deuterium	301-304	cystathionine beta-synthase	Homo sapiens	33-36
32171946-5	2020	In this study, we have found that the nickel chloride (NiCl2) treatment significantly downregulates the protein levels of endogenous H2S enzyme cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-Mercaptopyruvate sulfurtransferase (3-MST).	nickel chloride	38-53	cystathionine beta-synthase	Homo sapiens	144-171
32171946-5	2020	In this study, we have found that the nickel chloride (NiCl2) treatment significantly downregulates the protein levels of endogenous H2S enzyme cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-Mercaptopyruvate sulfurtransferase (3-MST).	nickel chloride	38-53	cystathionine beta-synthase	Homo sapiens	173-176
32171946-5	2020	In this study, we have found that the nickel chloride (NiCl2) treatment significantly downregulates the protein levels of endogenous H2S enzyme cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-Mercaptopyruvate sulfurtransferase (3-MST).	nickel chloride	55-60	cystathionine beta-synthase	Homo sapiens	144-171
32171946-5	2020	In this study, we have found that the nickel chloride (NiCl2) treatment significantly downregulates the protein levels of endogenous H2S enzyme cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-Mercaptopyruvate sulfurtransferase (3-MST).	nickel chloride	55-60	cystathionine beta-synthase	Homo sapiens	173-176
32171946-5	2020	In this study, we have found that the nickel chloride (NiCl2) treatment significantly downregulates the protein levels of endogenous H2S enzyme cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-Mercaptopyruvate sulfurtransferase (3-MST).	Deuterium	133-136	cystathionine beta-synthase	Homo sapiens	144-171
32171946-5	2020	In this study, we have found that the nickel chloride (NiCl2) treatment significantly downregulates the protein levels of endogenous H2S enzyme cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-Mercaptopyruvate sulfurtransferase (3-MST).	Deuterium	133-136	cystathionine beta-synthase	Homo sapiens	173-176
32212357-3	2020	Herein, we evaluate the performance of selected methods (like DLPNO-CCSD(T)) in FIA computations against CCSD(T)/CBS data and guide for the choice of suitable density functionals that allow the treatment of larger Lewis acids.	Lewis Acids	214-225	cystathionine beta-synthase	Homo sapiens	113-116
33318872-2	2021	The endogenous production of H2S is primarily mediated by cystathione beta-synthase (CBS), cystathione gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST).	Deuterium	29-32	cystathionine beta-synthase	Homo sapiens	85-88
32477150-4	2020	The cystathionine beta-synthase (CBS), 3-mercaptopyruvate sulfur transferase acts together with cysteine aminotransferase (3-MST/CAT), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfur transferase with D-amino acid oxidase (3-MST/DAO) pathways are involved in the enzymatic production of H2S.	Deuterium	301-304	cystathionine beta-synthase	Homo sapiens	4-31
32419814-0	2020	CBS-Induced H2S Generation in Hippocampus Inhibits EA-Induced Analgesia.	Deuterium	12-15	cystathionine beta-synthase	Homo sapiens	0-3
32057642-1	2020	Classical homocystinuria (HCU) is a genetic disorder caused by mutations in the cystathionine beta synthase gene, which results in impaired metabolism of the sulfur-bearing amino acid homocysteine and its accumulation in blood and tissues.	Sulfur	158-164	cystathionine beta-synthase	Homo sapiens	80-107
32057642-1	2020	Classical homocystinuria (HCU) is a genetic disorder caused by mutations in the cystathionine beta synthase gene, which results in impaired metabolism of the sulfur-bearing amino acid homocysteine and its accumulation in blood and tissues.	Homocysteine	184-196	cystathionine beta-synthase	Homo sapiens	80-107
32365821-5	2020	Among the small-molecule CBS inhibitors, the review highlights the specificity and selectivity problems related to many of the commonly used "CBS inhibitors" (e.g., aminooxyacetic acid) and provides a comprehensive review of their pharmacological actions under physiological conditions and in various disease models.	Aminooxyacetic Acid	165-184	cystathionine beta-synthase	Homo sapiens	25-28
32365821-5	2020	Among the small-molecule CBS inhibitors, the review highlights the specificity and selectivity problems related to many of the commonly used "CBS inhibitors" (e.g., aminooxyacetic acid) and provides a comprehensive review of their pharmacological actions under physiological conditions and in various disease models.	Aminooxyacetic Acid	165-184	cystathionine beta-synthase	Homo sapiens	142-145
32419814-5	2020	The results presented here show that S-adenosyl-l-methionine (SAM), an allosteric activator of cystathionine-beta-synthetase (CBS), may reverse the therapeutic effect of EA.	Methionine	47-60	cystathionine beta-synthase	Homo sapiens	126-129
32419814-5	2020	The results presented here show that S-adenosyl-l-methionine (SAM), an allosteric activator of cystathionine-beta-synthetase (CBS), may reverse the therapeutic effect of EA.	S-Adenosylmethionine	62-65	cystathionine beta-synthase	Homo sapiens	126-129
32419814-6	2020	CBS-induced H2S generation might get involved in the mechanism of EA-induced analgesia in the hippocampus on chronic inflammatory pain.	Deuterium	12-15	cystathionine beta-synthase	Homo sapiens	0-3
31864233-0	2020	CBS gene polymorphism and promoter methylation-mediating effects on the efficacy of folate therapy in patients with hyperhomocysteinemia.	Folic Acid	84-90	cystathionine beta-synthase	Homo sapiens	0-3
32340322-3	2020	Several lines of data indicate that an important enzyme responsible for H2S overproduction in Down syndrome is cystathionine-beta-synthase (CBS), an enzyme localized on chromosome 21.	Deuterium	72-75	cystathionine beta-synthase	Homo sapiens	111-138
32340322-3	2020	Several lines of data indicate that an important enzyme responsible for H2S overproduction in Down syndrome is cystathionine-beta-synthase (CBS), an enzyme localized on chromosome 21.	Deuterium	72-75	cystathionine beta-synthase	Homo sapiens	140-143
32131614-6	2020	Enzymes of the transsulfuration pathway, CBS (cystathionine beta-synthase) and CSE (cystathionine gamma-lyase), may also produce RSS metabolites besides hydrogen sulfide.	RSS	129-132	cystathionine beta-synthase	Homo sapiens	41-44
32131614-6	2020	Enzymes of the transsulfuration pathway, CBS (cystathionine beta-synthase) and CSE (cystathionine gamma-lyase), may also produce RSS metabolites besides hydrogen sulfide.	RSS	129-132	cystathionine beta-synthase	Homo sapiens	46-73
32131614-6	2020	Enzymes of the transsulfuration pathway, CBS (cystathionine beta-synthase) and CSE (cystathionine gamma-lyase), may also produce RSS metabolites besides hydrogen sulfide.	Hydrogen Sulfide	153-169	cystathionine beta-synthase	Homo sapiens	41-44
32131614-6	2020	Enzymes of the transsulfuration pathway, CBS (cystathionine beta-synthase) and CSE (cystathionine gamma-lyase), may also produce RSS metabolites besides hydrogen sulfide.	Hydrogen Sulfide	153-169	cystathionine beta-synthase	Homo sapiens	46-73
31864233-3	2020	The present study aimed to explore CBS promoter methylation-mediating effects on the efficacy of folate treatment for HHcy.	Folic Acid	97-103	cystathionine beta-synthase	Homo sapiens	35-38
31864233-10	2020	Additionally, baseline CBS promoter methylation mediated 33.39% of the effect of rs2851391 on the efficacy of folate treatment for HHcy (ACME [average causal mediation effects]: -0.05, 95% CI = -0.11 to 0.00, p = 0.046).	Folic Acid	110-116	cystathionine beta-synthase	Homo sapiens	23-26
31864233-12	2020	There were potentially causal effects of genetic, epigenetic variations at the CBS rs2851391 locus on the efficacy of HHcy therapy with folate.	Folic Acid	136-142	cystathionine beta-synthase	Homo sapiens	79-82
30500457-3	2020	Initial work identified cystathionine-beta-synthase (CBS) in many tumor cells as the key source of H2S.	Hydrogen Sulfide	99-102	cystathionine beta-synthase	Homo sapiens	24-51
31638087-4	2020	The enzymes cystathionine beta-synthase, cystathionine gamma-lya-se, and 3-mercaptopyruvate sulfurtransferase are involved in the enzymatic production of H2S.	Cystathionine	41-60	cystathionine beta-synthase	Homo sapiens	12-39
31638087-4	2020	The enzymes cystathionine beta-synthase, cystathionine gamma-lya-se, and 3-mercaptopyruvate sulfurtransferase are involved in the enzymatic production of H2S.	3-mercaptopyruvic acid	73-91	cystathionine beta-synthase	Homo sapiens	12-39
31638087-4	2020	The enzymes cystathionine beta-synthase, cystathionine gamma-lya-se, and 3-mercaptopyruvate sulfurtransferase are involved in the enzymatic production of H2S.	hydrogen sulfite	154-157	cystathionine beta-synthase	Homo sapiens	12-39
32091904-2	2020	In this work, this hydrogen abstraction reaction has been investigated at the CCSD(T)/CBS level of theory, suggesting that both pre-barrier complex and saddle point are stabilized in relation to the reactants by 3.31 and 1.35 kcal mol-1, respectively.	Hydrogen	19-27	cystathionine beta-synthase	Homo sapiens	86-89
31872317-5	2020	Moreover, exogenous H2S rescued LPS-induced cystathionine gamma-lyase (CSE) inhibition and cystathionine beta-synthase (CBS) synthesis.	hydrogen sulfite	20-23	cystathionine beta-synthase	Homo sapiens	91-118
31864811-1	2020	The family of cystathionine-beta-synthase (CBS)-pair domain divalent metal cation transport mediators (CNNMs) is composed of four integral membrane proteins associated with Mg2+ transport.	Magnesium	173-177	cystathionine beta-synthase	Homo sapiens	14-41
31938715-2	2020	Homocysteine is recycled back to methionine by methylenetetrahydrofolate reductase (MTHFR) and/or transsulfurated by cystathionine beta-synthase (CBS) to form cysteine.	Homocysteine	0-12	cystathionine beta-synthase	Homo sapiens	117-144
32041330-2	2020	-Cystathionase (CTH), cystathionine beta-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (MPST) are involved in H2S/sulfane sulfur endogenous formation from L-cysteine.	Deuterium	120-123	cystathionine beta-synthase	Homo sapiens	22-49
32041330-2	2020	-Cystathionase (CTH), cystathionine beta-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (MPST) are involved in H2S/sulfane sulfur endogenous formation from L-cysteine.	Deuterium	120-123	cystathionine beta-synthase	Homo sapiens	51-54
32041330-2	2020	-Cystathionase (CTH), cystathionine beta-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (MPST) are involved in H2S/sulfane sulfur endogenous formation from L-cysteine.	sulfane sulfur	124-138	cystathionine beta-synthase	Homo sapiens	22-49
32041330-2	2020	-Cystathionase (CTH), cystathionine beta-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (MPST) are involved in H2S/sulfane sulfur endogenous formation from L-cysteine.	sulfane sulfur	124-138	cystathionine beta-synthase	Homo sapiens	51-54
32041330-2	2020	-Cystathionase (CTH), cystathionine beta-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (MPST) are involved in H2S/sulfane sulfur endogenous formation from L-cysteine.	Cysteine	165-175	cystathionine beta-synthase	Homo sapiens	22-49
32041330-2	2020	-Cystathionase (CTH), cystathionine beta-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (MPST) are involved in H2S/sulfane sulfur endogenous formation from L-cysteine.	Cysteine	165-175	cystathionine beta-synthase	Homo sapiens	51-54
31017307-10	2020	Lowering endogenous production of H2 S by concomitant silencing of cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS) favoured VIC calcification.	Hydrogen	34-36	cystathionine beta-synthase	Homo sapiens	103-130
31051045-1	2020	BACKGROUND AND PURPOSE: Human malignant hyperthermia (MH) syndrome is induced by volatile anaesthetics and involves increased levels of cystathionine beta-synthase (CBS)-derived H2 S within skeletal muscle.	Hydrogen Sulfide	178-182	cystathionine beta-synthase	Homo sapiens	136-163
32031001-0	2020	Reaction of carbon monoxide with cystathionine beta-synthase: implications on drug efficacies in cancer chemotherapy.	Carbon Monoxide	12-27	cystathionine beta-synthase	Homo sapiens	33-60
32031001-3	2020	Findings from our group have shown CO to mitigate drug resistance in certain cancer cells by the inhibition of cystathionine beta-synthase (CBS), a key regulator of redox homeostasis in the cell.	Carbon Monoxide	35-37	cystathionine beta-synthase	Homo sapiens	111-138
32031001-3	2020	Findings from our group have shown CO to mitigate drug resistance in certain cancer cells by the inhibition of cystathionine beta-synthase (CBS), a key regulator of redox homeostasis in the cell.	Carbon Monoxide	35-37	cystathionine beta-synthase	Homo sapiens	140-143
31552888-9	2020	Hydrogen sulfide exhibits antioxidant effects against oxidative stress, where cystathionine beta synthase, cystathionine gamma lyase, and 3-mercaptopyruvate sulfurtransferase are the endogenous sources of hydrogen sulfide.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	78-105
31552888-9	2020	Hydrogen sulfide exhibits antioxidant effects against oxidative stress, where cystathionine beta synthase, cystathionine gamma lyase, and 3-mercaptopyruvate sulfurtransferase are the endogenous sources of hydrogen sulfide.	Hydrogen Sulfide	205-221	cystathionine beta-synthase	Homo sapiens	78-105
31714892-5	2020	H2S is synthesized by cystathionine beta-synthase and cystathionine gamma-lyase, which are the two enzymes in the transsulfuration pathway.	hydrogen sulfite	0-3	cystathionine beta-synthase	Homo sapiens	22-49
32000841-2	2020	Classical homocystinuria, characterized by elevated homocysteine in plasma and urine, is caused by variants in the cystathionine beta-synthase (CBS) gene, most of which are rare.	Homocysteine	52-64	cystathionine beta-synthase	Homo sapiens	115-142
32000841-2	2020	Classical homocystinuria, characterized by elevated homocysteine in plasma and urine, is caused by variants in the cystathionine beta-synthase (CBS) gene, most of which are rare.	Homocysteine	52-64	cystathionine beta-synthase	Homo sapiens	144-147
32194794-2	2020	Increased expression of cystathionine beta-synthase (CBS) and H2S in colon cancer tissue samples has been validated and tumor-derived H2S, mainly produced by CBS, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer.	Hydrogen Sulfide	134-137	cystathionine beta-synthase	Homo sapiens	158-161
32194794-4	2020	However, the effect of aminooxyacetic acid (AOAA), which has been widely used as an inhibitor of CBS dependent synthesis of H2S, on the chemotherapeutic effect of oxaliplatin (OXA) and the underlying mechanisms remain to be illustrated.	Aminooxyacetic Acid	23-42	cystathionine beta-synthase	Homo sapiens	97-100
32194794-4	2020	However, the effect of aminooxyacetic acid (AOAA), which has been widely used as an inhibitor of CBS dependent synthesis of H2S, on the chemotherapeutic effect of oxaliplatin (OXA) and the underlying mechanisms remain to be illustrated.	Aminooxyacetic Acid	44-48	cystathionine beta-synthase	Homo sapiens	97-100
32194794-4	2020	However, the effect of aminooxyacetic acid (AOAA), which has been widely used as an inhibitor of CBS dependent synthesis of H2S, on the chemotherapeutic effect of oxaliplatin (OXA) and the underlying mechanisms remain to be illustrated.	Hydrogen Sulfide	124-127	cystathionine beta-synthase	Homo sapiens	97-100
32194794-4	2020	However, the effect of aminooxyacetic acid (AOAA), which has been widely used as an inhibitor of CBS dependent synthesis of H2S, on the chemotherapeutic effect of oxaliplatin (OXA) and the underlying mechanisms remain to be illustrated.	Oxaliplatin	163-174	cystathionine beta-synthase	Homo sapiens	97-100
32194794-15	2020	Conclusion: The results suggested that CBS is overexpressed in colorectal cancer tissues and AOAA sensitizes colon cancer cells to OXA via exaggerating apoptosis both in vitro and in vivo.	Oxaliplatin	131-134	cystathionine beta-synthase	Homo sapiens	39-42
31938715-2	2020	Homocysteine is recycled back to methionine by methylenetetrahydrofolate reductase (MTHFR) and/or transsulfurated by cystathionine beta-synthase (CBS) to form cysteine.	Cysteine	4-12	cystathionine beta-synthase	Homo sapiens	117-144
31634482-3	2019	It was shown that these cells show a heavy reliance on cystathionine-beta-synthase (CBS)-derived hydrogen sulfide (H2S) during differentiation.	Hydrogen Sulfide	97-113	cystathionine beta-synthase	Homo sapiens	55-82
31819185-8	2020	CBS, the biosynthetic enzyme for cysteine, was constantly upregulated and was critical for the resistance.	Cysteine	33-41	cystathionine beta-synthase	Homo sapiens	0-3
31778995-3	2020	Methylenetetrahydrofolate reductase (MTHFR) and cystathionine B synthase (CBS) are major determinants of the homocysteine metabolism.	Homocysteine	109-121	cystathionine beta-synthase	Homo sapiens	48-72
31778995-3	2020	Methylenetetrahydrofolate reductase (MTHFR) and cystathionine B synthase (CBS) are major determinants of the homocysteine metabolism.	Homocysteine	109-121	cystathionine beta-synthase	Homo sapiens	74-77
31893496-2	2019	In mammalian tissues, H2S is synthesized endogenously from L-cysteine in regulated enzymatic pathways catalyzed by pyridoxal phosphate-dependent enzymes: cystathionine beta - synthase (CBS), gamma - cystathionase (CTH) and cysteine aminotransferase (CAT) coupled with 3-mercaptopyruvate sulfurtransferase (MPST).	Pyridoxal Phosphate	115-134	cystathionine beta-synthase	Homo sapiens	154-183
31893496-2	2019	In mammalian tissues, H2S is synthesized endogenously from L-cysteine in regulated enzymatic pathways catalyzed by pyridoxal phosphate-dependent enzymes: cystathionine beta - synthase (CBS), gamma - cystathionase (CTH) and cysteine aminotransferase (CAT) coupled with 3-mercaptopyruvate sulfurtransferase (MPST).	Pyridoxal Phosphate	115-134	cystathionine beta-synthase	Homo sapiens	185-188
31893496-2	2019	In mammalian tissues, H2S is synthesized endogenously from L-cysteine in regulated enzymatic pathways catalyzed by pyridoxal phosphate-dependent enzymes: cystathionine beta - synthase (CBS), gamma - cystathionase (CTH) and cysteine aminotransferase (CAT) coupled with 3-mercaptopyruvate sulfurtransferase (MPST).	Cysteine	61-69	cystathionine beta-synthase	Homo sapiens	154-183
31893496-2	2019	In mammalian tissues, H2S is synthesized endogenously from L-cysteine in regulated enzymatic pathways catalyzed by pyridoxal phosphate-dependent enzymes: cystathionine beta - synthase (CBS), gamma - cystathionase (CTH) and cysteine aminotransferase (CAT) coupled with 3-mercaptopyruvate sulfurtransferase (MPST).	Cysteine	61-69	cystathionine beta-synthase	Homo sapiens	185-188
31908954-6	2020	Individuals harboring cystathionine beta synthase (CBS) 833 T/844ins68 had lower Hcy concentrations than others.	Homocysteine	81-84	cystathionine beta-synthase	Homo sapiens	22-49
31842432-1	2019	The four member family of "Cyclin and Cystathionine beta-synthase (CBS) domain divalent metal cation transport mediators", CNNMs, are the least-studied mammalian magnesium transport mediators.	Magnesium	162-171	cystathionine beta-synthase	Homo sapiens	38-65
32865918-4	2020	ELISA assays quantified the amount of H2S produced by the two enzymes CBS and CSE.	Deuterium	38-41	cystathionine beta-synthase	Homo sapiens	70-73
32865918-5	2020	CCK-8 experiment was used to investigate the influence of the CBS inhibitor amino oxyacetic acid and the CSE inhibitor propargylglycine on the proliferation of U266 cells.	Aminooxyacetic Acid	76-96	cystathionine beta-synthase	Homo sapiens	62-65
32865918-12	2020	Conclusion-CBS/H2S system might have a certain effect on the proliferation and apoptosis of MM cells.	Deuterium	15-18	cystathionine beta-synthase	Homo sapiens	11-14
31893496-2	2019	In mammalian tissues, H2S is synthesized endogenously from L-cysteine in regulated enzymatic pathways catalyzed by pyridoxal phosphate-dependent enzymes: cystathionine beta - synthase (CBS), gamma - cystathionase (CTH) and cysteine aminotransferase (CAT) coupled with 3-mercaptopyruvate sulfurtransferase (MPST).	hydrogen sulfite	22-25	cystathionine beta-synthase	Homo sapiens	154-183
31893496-2	2019	In mammalian tissues, H2S is synthesized endogenously from L-cysteine in regulated enzymatic pathways catalyzed by pyridoxal phosphate-dependent enzymes: cystathionine beta - synthase (CBS), gamma - cystathionase (CTH) and cysteine aminotransferase (CAT) coupled with 3-mercaptopyruvate sulfurtransferase (MPST).	hydrogen sulfite	22-25	cystathionine beta-synthase	Homo sapiens	185-188
31893496-2	2019	In mammalian tissues, H2S is synthesized endogenously from L-cysteine in regulated enzymatic pathways catalyzed by pyridoxal phosphate-dependent enzymes: cystathionine beta - synthase (CBS), gamma - cystathionase (CTH) and cysteine aminotransferase (CAT) coupled with 3-mercaptopyruvate sulfurtransferase (MPST).	Cysteine	59-69	cystathionine beta-synthase	Homo sapiens	154-183
31634482-3	2019	It was shown that these cells show a heavy reliance on cystathionine-beta-synthase (CBS)-derived hydrogen sulfide (H2S) during differentiation.	Deuterium	115-118	cystathionine beta-synthase	Homo sapiens	55-82
31712792-3	2019	We have shown here that the binding energies calculated at the CCSD(T)/CBS level with counterpoise corrected geometries calculated at the MP2/aug-cc-pV(Q+d)Z level of theory excellently match with the experimental results for the H2S dimer.	hydrogen sulfite	230-233	cystathionine beta-synthase	Homo sapiens	71-74
31449969-6	2019	RESULTS: Proteomic analysis of fibroblasts identified upregulation of multiple proteins involved in serine synthesis and thiol metabolism including: phosphoserine amino transferase (PSAT1), cystathionine beta synthase (CBS), and mercaptopyruvate sulfurtransferase (MPST).	Serine	100-106	cystathionine beta-synthase	Homo sapiens	190-217
31542354-2	2019	Hydrogen sulfide (H2S), mainly produced by cystathionine-beta-synthase (CBS), has been reported to promote the proliferation and migration of colon cancer cells.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	43-70
31542354-2	2019	Hydrogen sulfide (H2S), mainly produced by cystathionine-beta-synthase (CBS), has been reported to promote the proliferation and migration of colon cancer cells.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	72-75
31542354-2	2019	Hydrogen sulfide (H2S), mainly produced by cystathionine-beta-synthase (CBS), has been reported to promote the proliferation and migration of colon cancer cells.	hydrogen sulfite	18-21	cystathionine beta-synthase	Homo sapiens	43-70
31542354-2	2019	Hydrogen sulfide (H2S), mainly produced by cystathionine-beta-synthase (CBS), has been reported to promote the proliferation and migration of colon cancer cells.	hydrogen sulfite	18-21	cystathionine beta-synthase	Homo sapiens	72-75
31641591-2	2019	Newborn screening by MS/MS on dried blood spot samples (DBS) has one of its items in methionine levels: the knowledge of this parameter allows the identification of infant affected by homocystinuria (cystathionine beta-synthase, CBS, deficiency) but can also lead, as side effect, to identify cases of methionine adenosyltransferase (MAT) type I/III deficiency.	Methionine	85-95	cystathionine beta-synthase	Homo sapiens	200-227
31885816-2	2019	Generation of H2S is closely associated with the metabolism of homocysteine via key enzymes such as cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	hydrogen sulfite	14-17	cystathionine beta-synthase	Homo sapiens	100-127
31885816-2	2019	Generation of H2S is closely associated with the metabolism of homocysteine via key enzymes such as cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	hydrogen sulfite	14-17	cystathionine beta-synthase	Homo sapiens	129-132
31885816-2	2019	Generation of H2S is closely associated with the metabolism of homocysteine via key enzymes such as cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Homocysteine	63-75	cystathionine beta-synthase	Homo sapiens	100-127
31885816-2	2019	Generation of H2S is closely associated with the metabolism of homocysteine via key enzymes such as cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Homocysteine	63-75	cystathionine beta-synthase	Homo sapiens	129-132
31885816-4	2019	Metabolic switch in the activity of CBS and CSE may occur with a resultant operating preference change of these enzymes in homocysteine and H2S metabolism.	Homocysteine	123-135	cystathionine beta-synthase	Homo sapiens	36-39
31885816-4	2019	Metabolic switch in the activity of CBS and CSE may occur with a resultant operating preference change of these enzymes in homocysteine and H2S metabolism.	hydrogen sulfite	140-143	cystathionine beta-synthase	Homo sapiens	36-39
31542487-8	2019	CYS produced relaxations of HCC and HPRA that were sensitive to ODQ and to inhibition of the H2S synthesizing enzymes, cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS).	Cysteine	0-3	cystathionine beta-synthase	Homo sapiens	155-182
31724756-0	2019	Estradiol-17beta inhibits homocysteine mediated damage by promoting H2 S production via upregulating CBS and CSE expression in human umbilical vein endothelial cells.	Estradiol	0-16	cystathionine beta-synthase	Homo sapiens	101-104
31724756-0	2019	Estradiol-17beta inhibits homocysteine mediated damage by promoting H2 S production via upregulating CBS and CSE expression in human umbilical vein endothelial cells.	Homocysteine	26-38	cystathionine beta-synthase	Homo sapiens	101-104
31724756-7	2019	Treatment with Hcy dampens the expression of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) then cuts down H2 S production in cultured HUVECs, however, E2beta reverses this process.	Homocysteine	15-18	cystathionine beta-synthase	Homo sapiens	45-72
31724756-7	2019	Treatment with Hcy dampens the expression of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) then cuts down H2 S production in cultured HUVECs, however, E2beta reverses this process.	Homocysteine	15-18	cystathionine beta-synthase	Homo sapiens	74-77
31724756-7	2019	Treatment with Hcy dampens the expression of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) then cuts down H2 S production in cultured HUVECs, however, E2beta reverses this process.	Hydrogen	130-132	cystathionine beta-synthase	Homo sapiens	45-72
31724756-9	2019	The role of E2beta was further strengthened by CBS and the CSE inhibitor through overthrowing the change in hydrogen sulfide of Hcy-treated HUVECs.	Hydrogen Sulfide	108-124	cystathionine beta-synthase	Homo sapiens	47-50
31724756-9	2019	The role of E2beta was further strengthened by CBS and the CSE inhibitor through overthrowing the change in hydrogen sulfide of Hcy-treated HUVECs.	Homocysteine	128-131	cystathionine beta-synthase	Homo sapiens	47-50
31558761-0	2019	Association between BHMT and CBS gene promoter methylation with the efficacy of folic acid therapy in patients with hyperhomocysteinemia.	Folic Acid	80-90	cystathionine beta-synthase	Homo sapiens	29-32
31558761-1	2019	Both betaine homocysteine methyltransferase (BHMT) and cystathionine beta-synthase (CBS) are major enzymes in the metabolism of plasma homocysteine (Hcy).	Homocysteine	149-152	cystathionine beta-synthase	Homo sapiens	55-82
31558761-1	2019	Both betaine homocysteine methyltransferase (BHMT) and cystathionine beta-synthase (CBS) are major enzymes in the metabolism of plasma homocysteine (Hcy).	Homocysteine	149-152	cystathionine beta-synthase	Homo sapiens	84-87
31558761-2	2019	Abnormal methylation levels of BHMT and CBS are positively associated with Hcy levels.	Homocysteine	75-78	cystathionine beta-synthase	Homo sapiens	40-43
31558761-3	2019	The present study is performed to explore the association between the methylation levels in the promoter regions of the BHMT and CBS genes and the efficacy of folic acid therapy in patient with hyperhomocysteinemia (HHcy).	Folic Acid	159-169	cystathionine beta-synthase	Homo sapiens	129-132
31558761-10	2019	These studies suggest that lower levels of BHMT and CBS methylation are all predictors of failure in folic acid therapy for HHcy.	Folic Acid	101-111	cystathionine beta-synthase	Homo sapiens	52-55
31345774-0	2019	NMR experiments on the transient interaction of the intrinsically disordered N-terminal peptide of cystathionine-beta-synthase with heme.	Heme	132-136	cystathionine beta-synthase	Homo sapiens	99-126
31345774-1	2019	The N-terminal segment of human cystathionine-beta-synthase (CBS(1-40)) constitutes an intrinsically disordered protein stretch that transiently interacts with heme.	Heme	160-164	cystathionine beta-synthase	Homo sapiens	32-59
31450076-5	2019	The chief enzyme which synthesizes H2S in brain parenchyma, cystathionine beta-synthase (CBS), employs cysteine as its rate-limiting substrate, and is allosterically activated by S-adenosylmethionine (SAM).	Hydrogen Sulfide	35-38	cystathionine beta-synthase	Homo sapiens	60-87
31450076-5	2019	The chief enzyme which synthesizes H2S in brain parenchyma, cystathionine beta-synthase (CBS), employs cysteine as its rate-limiting substrate, and is allosterically activated by S-adenosylmethionine (SAM).	Cysteine	103-111	cystathionine beta-synthase	Homo sapiens	60-87
31450076-5	2019	The chief enzyme which synthesizes H2S in brain parenchyma, cystathionine beta-synthase (CBS), employs cysteine as its rate-limiting substrate, and is allosterically activated by S-adenosylmethionine (SAM).	S-Adenosylmethionine	179-199	cystathionine beta-synthase	Homo sapiens	60-87
31450076-5	2019	The chief enzyme which synthesizes H2S in brain parenchyma, cystathionine beta-synthase (CBS), employs cysteine as its rate-limiting substrate, and is allosterically activated by S-adenosylmethionine (SAM).	S-Adenosylmethionine	201-204	cystathionine beta-synthase	Homo sapiens	60-87
31635026-3	2019	Different players in cysteine metabolism can be crucial in chemoresistance, such as the cystine/glutamate antiporter system Xc (xCT) and the H2S-synthesizing enzyme cystathionine beta-synthase (CBS) in the pathway of cysteine catabolism.	Cysteine	21-29	cystathionine beta-synthase	Homo sapiens	165-192
31635026-3	2019	Different players in cysteine metabolism can be crucial in chemoresistance, such as the cystine/glutamate antiporter system Xc (xCT) and the H2S-synthesizing enzyme cystathionine beta-synthase (CBS) in the pathway of cysteine catabolism.	hydrogen sulfite	141-144	cystathionine beta-synthase	Homo sapiens	165-192
31641591-2	2019	Newborn screening by MS/MS on dried blood spot samples (DBS) has one of its items in methionine levels: the knowledge of this parameter allows the identification of infant affected by homocystinuria (cystathionine beta-synthase, CBS, deficiency) but can also lead, as side effect, to identify cases of methionine adenosyltransferase (MAT) type I/III deficiency.	Methionine	85-95	cystathionine beta-synthase	Homo sapiens	229-232
30853492-1	2019	Hyperhomocysteinemia, resulting from a cystathionine beta synthase (CBS) deficiency, is an autosomal recessive disease associated with high levels of homocysteine.	Homocysteine	5-17	cystathionine beta-synthase	Homo sapiens	39-66
31582588-5	2019	The expression of CYS3 and CYS4, two transsulfuration pathway genes encoding cystathionine gamma-lyase (CGL) and cystathionine beta-synthase (CBS), were also decreased under mTORC1-Sch9 inhibition.	Cystathionine	113-126	cystathionine beta-synthase	Homo sapiens	142-145
31582588-7	2019	Finally, we also observed a reduction in H2S production and lowering of both mRNA and protein levels of CGL and CBS in cultured human cells treated with rapamycin to reduce mTORC1 pathway activity.	Sirolimus	153-162	cystathionine beta-synthase	Homo sapiens	112-115
31481613-0	2019	Overproduction of H2S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	36-39
31443780-3	2019	Indeed, a gene located on chromosome 21 controls the production of cystathionine-beta-synthase, an enzyme involved in hydrogen sulfide production in the central nervous system.	Hydrogen Sulfide	118-134	cystathionine beta-synthase	Homo sapiens	67-94
31481613-6	2019	In DS cells, pharmacological inhibition of CBS activity with aminooxyacetate or siRNA-mediated silencing of CBS normalized cellular H2S levels, restored Complex IV activity, improved mitochondrial electron transport and ATP synthesis, and restored cell proliferation.	Aminooxyacetic Acid	61-76	cystathionine beta-synthase	Homo sapiens	43-46
31481613-6	2019	In DS cells, pharmacological inhibition of CBS activity with aminooxyacetate or siRNA-mediated silencing of CBS normalized cellular H2S levels, restored Complex IV activity, improved mitochondrial electron transport and ATP synthesis, and restored cell proliferation.	Hydrogen Sulfide	132-135	cystathionine beta-synthase	Homo sapiens	43-46
31481613-6	2019	In DS cells, pharmacological inhibition of CBS activity with aminooxyacetate or siRNA-mediated silencing of CBS normalized cellular H2S levels, restored Complex IV activity, improved mitochondrial electron transport and ATP synthesis, and restored cell proliferation.	Hydrogen Sulfide	132-135	cystathionine beta-synthase	Homo sapiens	108-111
31481613-6	2019	In DS cells, pharmacological inhibition of CBS activity with aminooxyacetate or siRNA-mediated silencing of CBS normalized cellular H2S levels, restored Complex IV activity, improved mitochondrial electron transport and ATP synthesis, and restored cell proliferation.	Adenosine Triphosphate	220-223	cystathionine beta-synthase	Homo sapiens	108-111
31481613-7	2019	Thus, CBS-derived H2S is responsible for the suppression of mitochondrial function in DS cells.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	6-9
31146011-4	2019	NaHS adminstration restored the decreased levels of H2S and polysulfides with a concomitant increase in the activity of cystathionase (CSE) and cystathionine beta-synthase (CBS) in the brain regions of HHcy animals.	sodium bisulfide	0-4	cystathionine beta-synthase	Homo sapiens	144-171
31513688-0	2019	Retraction: Human Cystathionine-beta-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium.	serine227	65-74	cystathionine beta-synthase	Homo sapiens	18-45
31513688-0	2019	Retraction: Human Cystathionine-beta-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium.	Hydrogen Sulfide	85-101	cystathionine beta-synthase	Homo sapiens	18-45
31240737-6	2019	Both the steady-state protein levels and CBS enzyme activity levels in liver lysates from Tg-R336C Cbs -/- mice are significantly reduced compared to that found in Tg-hCBS Cbs -/- mice expressing wild-type human CBS.	Thioguanine	90-92	cystathionine beta-synthase	Homo sapiens	167-171
31240737-7	2019	Treatment of Tg-R336C Cbs -/- mice with the proteasome inhibitor bortezomib results in stabilization of liver CBS protein and an increase in activity to levels found in corresponding Tg-hCBS Cbs -/- wild type mice.	Thioguanine	13-15	cystathionine beta-synthase	Homo sapiens	186-190
31240737-7	2019	Treatment of Tg-R336C Cbs -/- mice with the proteasome inhibitor bortezomib results in stabilization of liver CBS protein and an increase in activity to levels found in corresponding Tg-hCBS Cbs -/- wild type mice.	Bortezomib	65-75	cystathionine beta-synthase	Homo sapiens	186-190
31240737-7	2019	Treatment of Tg-R336C Cbs -/- mice with the proteasome inhibitor bortezomib results in stabilization of liver CBS protein and an increase in activity to levels found in corresponding Tg-hCBS Cbs -/- wild type mice.	Thioguanine	183-185	cystathionine beta-synthase	Homo sapiens	186-190
31028914-2	2019	By studying the pretreatment of H2S donor sodium hydrosulfide (NaHS) and the scavenger hypotaurine (HT) and Cystathionine beta-synthase silenced strains, we found that H2S could alleviate the HS-induced ganoderic acids (GAs) biosynthesis.	Hydrogen Sulfide	168-171	cystathionine beta-synthase	Homo sapiens	108-135
31301157-3	2019	Cystathionine-beta-synthase (CBS) is an enzyme that catalyzes the first step of the transsulfuration pathway, from homocysteine to cystathionine, and in which variations are associated with human hyperhomocysteinemia and homocystinuria.	Homocysteine	115-127	cystathionine beta-synthase	Homo sapiens	0-27
31301157-3	2019	Cystathionine-beta-synthase (CBS) is an enzyme that catalyzes the first step of the transsulfuration pathway, from homocysteine to cystathionine, and in which variations are associated with human hyperhomocysteinemia and homocystinuria.	Homocysteine	115-127	cystathionine beta-synthase	Homo sapiens	29-32
31301157-3	2019	Cystathionine-beta-synthase (CBS) is an enzyme that catalyzes the first step of the transsulfuration pathway, from homocysteine to cystathionine, and in which variations are associated with human hyperhomocysteinemia and homocystinuria.	Cystathionine	131-144	cystathionine beta-synthase	Homo sapiens	0-27
31301157-3	2019	Cystathionine-beta-synthase (CBS) is an enzyme that catalyzes the first step of the transsulfuration pathway, from homocysteine to cystathionine, and in which variations are associated with human hyperhomocysteinemia and homocystinuria.	Cystathionine	131-144	cystathionine beta-synthase	Homo sapiens	29-32
30722010-2	2019	The current study investigated the role of cystathionine beta-synthase [CBS], a major producer of H2S in colon epithelial cells, in the pathogenesis of ulcerative colitis [UC]-related intestinal barrier injury.	Hydrogen Sulfide	98-101	cystathionine beta-synthase	Homo sapiens	43-70
31398016-6	2019	Similar to yeast and human CBS, LS can generate H2S and l-cystathionine through beta-replacement of l-cysteine by a second molecule of l-homocysteine; however, whereas this is the main H2S-forming reaction in CBS, it is not for LS.	Hydrogen Sulfide	48-51	cystathionine beta-synthase	Homo sapiens	27-30
31398016-8	2019	Sequence alignment of LS with other CBS and OASS enzymes and inspection of the LS crystal structure in the external aldimine state with l-lanthionine reveal that LS possesses a unique loop that engages in hydrogen-bond contact with the product, providing a structural rationale for the enzyme"s catalytic preference for H2S and l-lanthionine biosynthesis.	lanthionine	136-149	cystathionine beta-synthase	Homo sapiens	36-39
31398016-8	2019	Sequence alignment of LS with other CBS and OASS enzymes and inspection of the LS crystal structure in the external aldimine state with l-lanthionine reveal that LS possesses a unique loop that engages in hydrogen-bond contact with the product, providing a structural rationale for the enzyme"s catalytic preference for H2S and l-lanthionine biosynthesis.	Hydrogen	205-213	cystathionine beta-synthase	Homo sapiens	36-39
31398016-8	2019	Sequence alignment of LS with other CBS and OASS enzymes and inspection of the LS crystal structure in the external aldimine state with l-lanthionine reveal that LS possesses a unique loop that engages in hydrogen-bond contact with the product, providing a structural rationale for the enzyme"s catalytic preference for H2S and l-lanthionine biosynthesis.	Hydrogen Sulfide	320-323	cystathionine beta-synthase	Homo sapiens	36-39
31398016-8	2019	Sequence alignment of LS with other CBS and OASS enzymes and inspection of the LS crystal structure in the external aldimine state with l-lanthionine reveal that LS possesses a unique loop that engages in hydrogen-bond contact with the product, providing a structural rationale for the enzyme"s catalytic preference for H2S and l-lanthionine biosynthesis.	lanthionine	328-341	cystathionine beta-synthase	Homo sapiens	36-39
31443288-6	2019	Pre-treatment of H2S also decreased H2O2-induced suppression of endogenous H2S production enzymes, cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE), and 3-mercapto-pyruvate sulfurtransferase (MPST).	Hydrogen Sulfide	17-20	cystathionine beta-synthase	Homo sapiens	99-126
31443288-6	2019	Pre-treatment of H2S also decreased H2O2-induced suppression of endogenous H2S production enzymes, cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE), and 3-mercapto-pyruvate sulfurtransferase (MPST).	Hydrogen Peroxide	36-40	cystathionine beta-synthase	Homo sapiens	99-126
31314528-2	2019	The structural analyses utilized gas electron diffraction supported by high-level quantum calculations, while the pathway for the unimolecular hydrogen release reaction in the absence and presence of BH3 as a bifunctional catalyst was predicted at the CBS-QB3 level.	Hydrogen	143-151	cystathionine beta-synthase	Homo sapiens	252-255
31314528-2	2019	The structural analyses utilized gas electron diffraction supported by high-level quantum calculations, while the pathway for the unimolecular hydrogen release reaction in the absence and presence of BH3 as a bifunctional catalyst was predicted at the CBS-QB3 level.	BH 3	200-203	cystathionine beta-synthase	Homo sapiens	252-255
31314528-4	2019	The predicted enthalpy of dehydrogenation at the CCSD(T)/CBS level indicates that mild reaction conditions would be required for hydrogen release and that the compound is closer to thermoneutral than linear amine boranes.	Hydrogen	28-36	cystathionine beta-synthase	Homo sapiens	57-60
31314528-4	2019	The predicted enthalpy of dehydrogenation at the CCSD(T)/CBS level indicates that mild reaction conditions would be required for hydrogen release and that the compound is closer to thermoneutral than linear amine boranes.	amine boranes	207-220	cystathionine beta-synthase	Homo sapiens	57-60
30722010-2	2019	The current study investigated the role of cystathionine beta-synthase [CBS], a major producer of H2S in colon epithelial cells, in the pathogenesis of ulcerative colitis [UC]-related intestinal barrier injury.	Hydrogen Sulfide	98-101	cystathionine beta-synthase	Homo sapiens	72-75
31132312-1	2019	O-acetylserine sulfhydrylase (OASS) and cystathionine beta-synthase (CBS) are members of the PLP-II family, and involved in L-cysteine production.	Cysteine	124-134	cystathionine beta-synthase	Homo sapiens	40-67
31132312-1	2019	O-acetylserine sulfhydrylase (OASS) and cystathionine beta-synthase (CBS) are members of the PLP-II family, and involved in L-cysteine production.	Cysteine	124-134	cystathionine beta-synthase	Homo sapiens	69-72
31132312-3	2019	O-acetylserine-dependent CBS (OCBS) was previously identified as a new member of the PLP-II family, which are predominantly seen in bacteria.	O-acetylserine	0-14	cystathionine beta-synthase	Homo sapiens	25-28
30928641-2	2019	Multiple enzymes such as cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and 3-Mercaptopyruvate sulfurtransferase (MST) produce endogenous H2S, and these are differentially expressed in the various tissue systems including the skeletal system.	Hydrogen Sulfide	158-161	cystathionine beta-synthase	Homo sapiens	25-52
31120181-1	2019	The mechanisms of the thermal reactions of the two iconic magnesium oxide cations MgO.+ and Mg2 O2 .+ with methane have been re-evaluated at the CCSD(T)/CBS//CCSD/def2-TZVP level of theory.	Magnesium Oxide	58-73	cystathionine beta-synthase	Homo sapiens	153-156
31120181-1	2019	The mechanisms of the thermal reactions of the two iconic magnesium oxide cations MgO.+ and Mg2 O2 .+ with methane have been re-evaluated at the CCSD(T)/CBS//CCSD/def2-TZVP level of theory.	Magnesium Oxide	82-87	cystathionine beta-synthase	Homo sapiens	153-156
31120181-1	2019	The mechanisms of the thermal reactions of the two iconic magnesium oxide cations MgO.+ and Mg2 O2 .+ with methane have been re-evaluated at the CCSD(T)/CBS//CCSD/def2-TZVP level of theory.	mg2 o2 .+	92-101	cystathionine beta-synthase	Homo sapiens	153-156
31120181-1	2019	The mechanisms of the thermal reactions of the two iconic magnesium oxide cations MgO.+ and Mg2 O2 .+ with methane have been re-evaluated at the CCSD(T)/CBS//CCSD/def2-TZVP level of theory.	Methane	107-114	cystathionine beta-synthase	Homo sapiens	153-156
29790379-3	2019	Recent Advances: The three H2S-producing enzymes, namely cystathionine gamma-lyase (CSE), cystathionine beta-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3MST), have been found to be highly expressed in numerous types of cancer.	Hydrogen Sulfide	27-30	cystathionine beta-synthase	Homo sapiens	90-117
29790379-3	2019	Recent Advances: The three H2S-producing enzymes, namely cystathionine gamma-lyase (CSE), cystathionine beta-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (3MST), have been found to be highly expressed in numerous types of cancer.	Hydrogen Sulfide	27-30	cystathionine beta-synthase	Homo sapiens	119-122
31269401-6	2019	The relative energies of these isomers, calculated at the CCSDT(Q)/CBS level of theory, with respect to linear triplet pentadiynylidene (1) reveal that they all lie within 25.1 kcal mol-1.	pentadiynylidene	119-135	cystathionine beta-synthase	Homo sapiens	67-70
31160338-7	2019	We noted that CPC spared the other enzymes involved either directly (cystathionine beta-synthase and mercaptopyruvate sulfurtransferase) or indirectly (cysteine aminotransferase) in H2S biogenesis.	cpc	14-17	cystathionine beta-synthase	Homo sapiens	69-96
30928641-2	2019	Multiple enzymes such as cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and 3-Mercaptopyruvate sulfurtransferase (MST) produce endogenous H2S, and these are differentially expressed in the various tissue systems including the skeletal system.	Hydrogen Sulfide	158-161	cystathionine beta-synthase	Homo sapiens	54-57
31231626-7	2019	In healthy conditions, H2S-related enzymes (e.g., cystathionine beta-synthase and cystathionine gamma-lyase) are expressed in human lungs, where they have mucolytic, antioxidant, anti-inflammatory, and antibacterial roles, thus contributing to airway epithelium homeostasis.	Hydrogen Sulfide	23-26	cystathionine beta-synthase	Homo sapiens	50-77
30317617-1	2019	Endogenous hydrogen sulfide (H2 S), synthesized by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), is a potent vasodilator that can be stimulated by estradiol-17beta (E 2 beta) in uterine artery (UA) smooth muscle (UASMC) in vivo; however, the underlying mechanisms are unknown.	Hydrogen Sulfide	11-27	cystathionine beta-synthase	Homo sapiens	51-78
30317617-1	2019	Endogenous hydrogen sulfide (H2 S), synthesized by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), is a potent vasodilator that can be stimulated by estradiol-17beta (E 2 beta) in uterine artery (UA) smooth muscle (UASMC) in vivo; however, the underlying mechanisms are unknown.	Hydrogen Sulfide	29-33	cystathionine beta-synthase	Homo sapiens	51-78
30317617-1	2019	Endogenous hydrogen sulfide (H2 S), synthesized by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), is a potent vasodilator that can be stimulated by estradiol-17beta (E 2 beta) in uterine artery (UA) smooth muscle (UASMC) in vivo; however, the underlying mechanisms are unknown.	Estradiol	172-188	cystathionine beta-synthase	Homo sapiens	51-78
30238388-8	2019	These results may allow us to better understand the role of the transsulfuration pathway and especially CBS overexpression in the metabolism of biogenic amines and the catecholamine catabolism in persons with trisomy 21.	Amines	153-159	cystathionine beta-synthase	Homo sapiens	104-107
30238388-8	2019	These results may allow us to better understand the role of the transsulfuration pathway and especially CBS overexpression in the metabolism of biogenic amines and the catecholamine catabolism in persons with trisomy 21.	Catecholamines	168-181	cystathionine beta-synthase	Homo sapiens	104-107
30862476-3	2019	Therefore we assessed the expressional kinetics of potential H2S-producing enzymes during undisturbed skin repair: the cystathionine-gamma-lyase (CSE), the cystathionine-beta-synthase (CBS) and the 3-mercaptopyruvate sulfurtransferase (MPST).	Hydrogen Sulfide	61-64	cystathionine beta-synthase	Homo sapiens	156-183
31178749-3	2019	We have previously shown that a hydrogen sulfide (H2S), a by-product of Hcy through transsulfuration by cystathionine beta synthase (CBS), donor mitigates Hcy-induced hypertrophy in cardiomyocytes.	Hydrogen Sulfide	32-48	cystathionine beta-synthase	Homo sapiens	133-136
31178749-3	2019	We have previously shown that a hydrogen sulfide (H2S), a by-product of Hcy through transsulfuration by cystathionine beta synthase (CBS), donor mitigates Hcy-induced hypertrophy in cardiomyocytes.	Hydrogen Sulfide	50-53	cystathionine beta-synthase	Homo sapiens	104-131
31178749-3	2019	We have previously shown that a hydrogen sulfide (H2S), a by-product of Hcy through transsulfuration by cystathionine beta synthase (CBS), donor mitigates Hcy-induced hypertrophy in cardiomyocytes.	Hydrogen Sulfide	32-48	cystathionine beta-synthase	Homo sapiens	104-131
31178749-3	2019	We have previously shown that a hydrogen sulfide (H2S), a by-product of Hcy through transsulfuration by cystathionine beta synthase (CBS), donor mitigates Hcy-induced hypertrophy in cardiomyocytes.	Hydrogen Sulfide	50-53	cystathionine beta-synthase	Homo sapiens	133-136
31178749-3	2019	We have previously shown that a hydrogen sulfide (H2S), a by-product of Hcy through transsulfuration by cystathionine beta synthase (CBS), donor mitigates Hcy-induced hypertrophy in cardiomyocytes.	Homocysteine	72-75	cystathionine beta-synthase	Homo sapiens	104-131
31178749-3	2019	We have previously shown that a hydrogen sulfide (H2S), a by-product of Hcy through transsulfuration by cystathionine beta synthase (CBS), donor mitigates Hcy-induced hypertrophy in cardiomyocytes.	Homocysteine	72-75	cystathionine beta-synthase	Homo sapiens	133-136
31178749-3	2019	We have previously shown that a hydrogen sulfide (H2S), a by-product of Hcy through transsulfuration by cystathionine beta synthase (CBS), donor mitigates Hcy-induced hypertrophy in cardiomyocytes.	Homocysteine	155-158	cystathionine beta-synthase	Homo sapiens	104-131
31178749-3	2019	We have previously shown that a hydrogen sulfide (H2S), a by-product of Hcy through transsulfuration by cystathionine beta synthase (CBS), donor mitigates Hcy-induced hypertrophy in cardiomyocytes.	Homocysteine	155-158	cystathionine beta-synthase	Homo sapiens	133-136
30234368-3	2019	In 1996, Dr. Kimura demonstrated a physiological role of H2S as a mediator of cognitive function and cystathionine beta-synthase as an H2S-producing enzyme.	Hydrogen Sulfide	135-138	cystathionine beta-synthase	Homo sapiens	101-128
31022181-6	2019	Comparison of structures derived from protein studied in different experimental conditions supports the notion that pH and adenine nucleotides regulate ClC-1 through interactions between the so-called cystathionine-beta-synthase (CBS) domains and the intracellular vestibule ("slow gating").	Adenine Nucleotides	123-142	cystathionine beta-synthase	Homo sapiens	201-228
31071929-10	2019	(3) We demonstrated that, in endothelial cells, lanthionine hampers H2S release; reduces protein content and glutathionylation of transsulfuration enzyme cystathionine-beta-synthase; modifies the expression of miR-200c and miR-423; lowers expression of vascular endothelial growth factor VEGF; increases Ca2+ levels.	lanthionine	48-59	cystathionine beta-synthase	Homo sapiens	154-181
31022181-6	2019	Comparison of structures derived from protein studied in different experimental conditions supports the notion that pH and adenine nucleotides regulate ClC-1 through interactions between the so-called cystathionine-beta-synthase (CBS) domains and the intracellular vestibule ("slow gating").	Adenine Nucleotides	123-142	cystathionine beta-synthase	Homo sapiens	230-233
30926772-5	2019	In mammalian species, the generation of H2S is catalyzed by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), 3-mercapto-methylthio pyruvate aminotransferase (3MST) and cysteine aminotransferase (CAT).	Hydrogen Sulfide	40-43	cystathionine beta-synthase	Homo sapiens	60-87
30653965-3	2019	H2S production is driven by cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), the key enzymes that also drive transsulfuration pathway (TSP) necessary for GSH production.	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	64-91
30653965-3	2019	H2S production is driven by cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), the key enzymes that also drive transsulfuration pathway (TSP) necessary for GSH production.	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	93-96
30653965-3	2019	H2S production is driven by cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), the key enzymes that also drive transsulfuration pathway (TSP) necessary for GSH production.	Glutathione	176-179	cystathionine beta-synthase	Homo sapiens	64-91
30653965-3	2019	H2S production is driven by cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS), the key enzymes that also drive transsulfuration pathway (TSP) necessary for GSH production.	Glutathione	176-179	cystathionine beta-synthase	Homo sapiens	93-96
30653965-13	2019	Together, these findings reveal that CSE and CBS are expressed in the retina, thereby supporting further studies to determine the role of H2S and these proteins in oxidative stress and apoptosis in retinal degenerative diseases.	Hydrogen Sulfide	138-141	cystathionine beta-synthase	Homo sapiens	45-48
30926772-5	2019	In mammalian species, the generation of H2S is catalyzed by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), 3-mercapto-methylthio pyruvate aminotransferase (3MST) and cysteine aminotransferase (CAT).	Hydrogen Sulfide	40-43	cystathionine beta-synthase	Homo sapiens	89-92
30918891-5	2019	The possible cross-talk between the PLP enzymes hSR and hCBS (human cystathionine beta-synthase) is discussed, as the former produces D-serine and the latter produces H2S, both of which stimulate the NMDAR and both of which have been implicated in neuronal infarction pursuant to ischemic stroke.	D-serine	134-142	cystathionine beta-synthase	Homo sapiens	56-60
30916171-1	2019	OBJECTIVES: Cystathionine beta-synthase is a major enzyme in the metabolism of plasma homocysteine.	Homocysteine	86-98	cystathionine beta-synthase	Homo sapiens	12-39
30871635-8	2019	The median total daily dose of betaine anhydrous at the first and last study visits was 6 g/day for cystathionine beta-synthase (CBS)-deficient vitamin B6 responders and 9 g/day for methylenetetrahydrofolate reductase-deficient patients, while the median daily dose increased in CBS-deficient B6 non-responders (from 6 to 9 g/day) and cobalamin metabolism-defective patients (from 3 to 6 g/day) between the first and last visits.	Betaine	31-38	cystathionine beta-synthase	Homo sapiens	100-127
30871635-8	2019	The median total daily dose of betaine anhydrous at the first and last study visits was 6 g/day for cystathionine beta-synthase (CBS)-deficient vitamin B6 responders and 9 g/day for methylenetetrahydrofolate reductase-deficient patients, while the median daily dose increased in CBS-deficient B6 non-responders (from 6 to 9 g/day) and cobalamin metabolism-defective patients (from 3 to 6 g/day) between the first and last visits.	Betaine	31-38	cystathionine beta-synthase	Homo sapiens	129-132
30918891-5	2019	The possible cross-talk between the PLP enzymes hSR and hCBS (human cystathionine beta-synthase) is discussed, as the former produces D-serine and the latter produces H2S, both of which stimulate the NMDAR and both of which have been implicated in neuronal infarction pursuant to ischemic stroke.	D-serine	134-142	cystathionine beta-synthase	Homo sapiens	68-95
30918891-5	2019	The possible cross-talk between the PLP enzymes hSR and hCBS (human cystathionine beta-synthase) is discussed, as the former produces D-serine and the latter produces H2S, both of which stimulate the NMDAR and both of which have been implicated in neuronal infarction pursuant to ischemic stroke.	Hydrogen Sulfide	167-170	cystathionine beta-synthase	Homo sapiens	56-60
30918891-5	2019	The possible cross-talk between the PLP enzymes hSR and hCBS (human cystathionine beta-synthase) is discussed, as the former produces D-serine and the latter produces H2S, both of which stimulate the NMDAR and both of which have been implicated in neuronal infarction pursuant to ischemic stroke.	Hydrogen Sulfide	167-170	cystathionine beta-synthase	Homo sapiens	68-95
30277497-0	2019	E2beta stimulates ovine uterine artery endothelial cell H2S production in vitro by estrogen receptor-dependent upregulation of cystathionine beta-synthase and cystathionine gamma-lyase expression .	Deuterium	56-59	cystathionine beta-synthase	Homo sapiens	127-154
30265375-3	2019	The expressions of endogenous H2 S producing enzymes, namely cystathionine beta-synthase, cystathionine gamma-lyase and 3-mercaptopyruvate sulfur transferase, were detected by reverse transcription-polymerase chain reaction and western blotting.	Hydrogen Sulfide	30-34	cystathionine beta-synthase	Homo sapiens	61-88
30265375-6	2019	PQ significantly downregulated the expression levels of cystathionine beta-synthase and cystathionine gamma-lyase, but not 3-mercaptopyruvate sulfur transferase, in a time-dependent manner in A549 cells.	Paraquat	0-2	cystathionine beta-synthase	Homo sapiens	56-83
30845649-1	2019	The cyclin and cystathionine beta-synthase (CBS) domain magnesium transport mediators, CNNMs, are key players in maintaining the homeostasis of magnesium in different organs.	Magnesium	56-65	cystathionine beta-synthase	Homo sapiens	15-42
30845649-1	2019	The cyclin and cystathionine beta-synthase (CBS) domain magnesium transport mediators, CNNMs, are key players in maintaining the homeostasis of magnesium in different organs.	Magnesium	56-65	cystathionine beta-synthase	Homo sapiens	44-47
30845649-1	2019	The cyclin and cystathionine beta-synthase (CBS) domain magnesium transport mediators, CNNMs, are key players in maintaining the homeostasis of magnesium in different organs.	Magnesium	144-153	cystathionine beta-synthase	Homo sapiens	15-42
30845649-1	2019	The cyclin and cystathionine beta-synthase (CBS) domain magnesium transport mediators, CNNMs, are key players in maintaining the homeostasis of magnesium in different organs.	Magnesium	144-153	cystathionine beta-synthase	Homo sapiens	44-47
30277497-4	2019	In cultured primary UAEC, treatment with estradiol-17beta (E2beta) stimulated CBS and CTH mRNAs and proteins in a time- and concentration-dependent fashion.	Estradiol	41-57	cystathionine beta-synthase	Homo sapiens	78-81
30277497-1	2019	Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger synthesized from L-cysteine by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CTH).	Hydrogen Sulfide	11-27	cystathionine beta-synthase	Homo sapiens	124-151
30277497-6	2019	Treatment with E2beta stimulated H2S production, which was blocked by specific inhibitors of either CBS or CTH and their combination and the ER antagonist ICI 182780.	Deuterium	33-36	cystathionine beta-synthase	Homo sapiens	100-103
30277497-1	2019	Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger synthesized from L-cysteine by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CTH).	Hydrogen Sulfide	11-27	cystathionine beta-synthase	Homo sapiens	153-156
30277497-10	2019	Thus, E2beta stimulates H2S production by upregulating CBS and CTH mRNA and protein expressions through specific ERalpha or ERbeta-dependent CBS and CTH transcription in UAEC in vitro.	Deuterium	24-27	cystathionine beta-synthase	Homo sapiens	55-58
30277497-1	2019	Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger synthesized from L-cysteine by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CTH).	Deuterium	29-32	cystathionine beta-synthase	Homo sapiens	124-151
30277497-1	2019	Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger synthesized from L-cysteine by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CTH).	Deuterium	29-32	cystathionine beta-synthase	Homo sapiens	153-156
30277497-10	2019	Thus, E2beta stimulates H2S production by upregulating CBS and CTH mRNA and protein expressions through specific ERalpha or ERbeta-dependent CBS and CTH transcription in UAEC in vitro.	Deuterium	24-27	cystathionine beta-synthase	Homo sapiens	141-144
30277497-1	2019	Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger synthesized from L-cysteine by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CTH).	Cysteine	110-120	cystathionine beta-synthase	Homo sapiens	124-151
30277497-1	2019	Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger synthesized from L-cysteine by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CTH).	Cysteine	110-120	cystathionine beta-synthase	Homo sapiens	153-156
30458366-8	2019	These cisplatin-resistant cell lines overexpressed CBS and had increased steady state levels of GSH and expression of nuclear MT.	Cisplatin	6-15	cystathionine beta-synthase	Homo sapiens	51-54
30458366-9	2019	Both CO treatment and lentiviral-mediated silencing of CBS attenuated GSH and nuclear MT expression in cisplatin resistant cells.	Glutathione	70-73	cystathionine beta-synthase	Homo sapiens	55-58
30458366-4	2019	Cystathionine beta-synthase (CBS), an enzyme involved in sulfur metabolism, is overexpressed in ovarian cancer tissues and is itself associated with cisplatin resistance.	Sulfur	57-63	cystathionine beta-synthase	Homo sapiens	0-27
30458366-9	2019	Both CO treatment and lentiviral-mediated silencing of CBS attenuated GSH and nuclear MT expression in cisplatin resistant cells.	Cisplatin	103-112	cystathionine beta-synthase	Homo sapiens	55-58
30458366-4	2019	Cystathionine beta-synthase (CBS), an enzyme involved in sulfur metabolism, is overexpressed in ovarian cancer tissues and is itself associated with cisplatin resistance.	Sulfur	57-63	cystathionine beta-synthase	Homo sapiens	29-32
30116976-1	2018	PURPOSE OF REVIEW: Homocystinuria is a congenital metabolic disorder in which cystathionine beta-synthase deficiency results in a prominent increase in homocysteine (serum levels &gt; 100 muM), causing mental retardation, atherosclerotic cerebral infarction, and osteoporosis accompanied by fragility fractures.	Homocysteine	152-164	cystathionine beta-synthase	Homo sapiens	78-105
30458366-4	2019	Cystathionine beta-synthase (CBS), an enzyme involved in sulfur metabolism, is overexpressed in ovarian cancer tissues and is itself associated with cisplatin resistance.	Cisplatin	149-158	cystathionine beta-synthase	Homo sapiens	0-27
30458366-4	2019	Cystathionine beta-synthase (CBS), an enzyme involved in sulfur metabolism, is overexpressed in ovarian cancer tissues and is itself associated with cisplatin resistance.	Cisplatin	149-158	cystathionine beta-synthase	Homo sapiens	29-32
30458366-5	2019	Treatment with exogenous carbon monoxide (CO), a known inhibitor of CBS, may mitigate cisplatin resistance in ovarian cancer cells by attenuation of GSH and MT levels.	Carbon Monoxide	25-40	cystathionine beta-synthase	Homo sapiens	68-71
30458366-5	2019	Treatment with exogenous carbon monoxide (CO), a known inhibitor of CBS, may mitigate cisplatin resistance in ovarian cancer cells by attenuation of GSH and MT levels.	Carbon Monoxide	42-44	cystathionine beta-synthase	Homo sapiens	68-71
30458366-5	2019	Treatment with exogenous carbon monoxide (CO), a known inhibitor of CBS, may mitigate cisplatin resistance in ovarian cancer cells by attenuation of GSH and MT levels.	Cisplatin	86-95	cystathionine beta-synthase	Homo sapiens	68-71
30458366-5	2019	Treatment with exogenous carbon monoxide (CO), a known inhibitor of CBS, may mitigate cisplatin resistance in ovarian cancer cells by attenuation of GSH and MT levels.	Glutathione	149-152	cystathionine beta-synthase	Homo sapiens	68-71
30679627-1	2019	Biosynthesis of hydrogen sulfide (H2S), a key signalling molecule in human (patho)physiology, is mostly accomplished by the human enzymes cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (MST).	Hydrogen Sulfide	16-32	cystathionine beta-synthase	Homo sapiens	138-165
30679627-1	2019	Biosynthesis of hydrogen sulfide (H2S), a key signalling molecule in human (patho)physiology, is mostly accomplished by the human enzymes cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (MST).	Hydrogen Sulfide	16-32	cystathionine beta-synthase	Homo sapiens	167-170
30679627-1	2019	Biosynthesis of hydrogen sulfide (H2S), a key signalling molecule in human (patho)physiology, is mostly accomplished by the human enzymes cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (MST).	Hydrogen Sulfide	34-37	cystathionine beta-synthase	Homo sapiens	138-165
30679627-1	2019	Biosynthesis of hydrogen sulfide (H2S), a key signalling molecule in human (patho)physiology, is mostly accomplished by the human enzymes cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (MST).	Hydrogen Sulfide	34-37	cystathionine beta-synthase	Homo sapiens	167-170
30679627-4	2019	Here, the human enzymes CBS, CSE and MST were expressed and purified from Escherichia coli, and thirty-one pyridine derivatives were synthesized and screened for their ability to bind and inhibit these enzymes.	pyridine	107-115	cystathionine beta-synthase	Homo sapiens	24-27
30534696-11	2019	Here, we found that the levels of pSTAT3 and BCL-2 were decreased in CBS knockdown HepG2 cells and the combination of curcumenol and laminarin significantly decreased the H2S level in a dose-dependent manner and down-regulated the levels of pSTAT3 and BCL-2 in HepG2 cells.	Hydrogen Sulfide	171-174	cystathionine beta-synthase	Homo sapiens	69-72
31148102-2	2019	H2S is synthesized from L-cysteine and/or L-homocysteine by cystathionine beta-synthase, cystathionine gamma-lyase, and cysteine aminotransferase together with 3-mercaptopyruvate sulfurtransferase.	Deuterium	0-3	cystathionine beta-synthase	Homo sapiens	60-87
31148102-2	2019	H2S is synthesized from L-cysteine and/or L-homocysteine by cystathionine beta-synthase, cystathionine gamma-lyase, and cysteine aminotransferase together with 3-mercaptopyruvate sulfurtransferase.	Cysteine	24-34	cystathionine beta-synthase	Homo sapiens	60-87
31148102-2	2019	H2S is synthesized from L-cysteine and/or L-homocysteine by cystathionine beta-synthase, cystathionine gamma-lyase, and cysteine aminotransferase together with 3-mercaptopyruvate sulfurtransferase.	Homocysteine	42-56	cystathionine beta-synthase	Homo sapiens	60-87
30662667-1	2018	Hydrogen sulfide (H2S) is substantially converted from cysteine by the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	79-106
30662667-1	2018	Hydrogen sulfide (H2S) is substantially converted from cysteine by the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	108-111
30662667-1	2018	Hydrogen sulfide (H2S) is substantially converted from cysteine by the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	79-106
30662667-1	2018	Hydrogen sulfide (H2S) is substantially converted from cysteine by the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	108-111
30662667-1	2018	Hydrogen sulfide (H2S) is substantially converted from cysteine by the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Cysteine	55-63	cystathionine beta-synthase	Homo sapiens	79-106
30662667-1	2018	Hydrogen sulfide (H2S) is substantially converted from cysteine by the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Cysteine	55-63	cystathionine beta-synthase	Homo sapiens	108-111
29896909-4	2018	Immunoblotting was used to measure levels of H2 S-synthesizing enzymes: cystathionine-beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulphurtransferase (MPST).	Hydrogen	45-47	cystathionine beta-synthase	Homo sapiens	72-99
30380942-3	2018	Cystathionine beta-synthase (CBS) plays an important role in Hcy homeostasis catalyzing the irreversible degradation of Hcy to cystathionine, protecting the endothelium from injury caused by hypoxia.	Homocysteine	61-64	cystathionine beta-synthase	Homo sapiens	0-27
30380942-3	2018	Cystathionine beta-synthase (CBS) plays an important role in Hcy homeostasis catalyzing the irreversible degradation of Hcy to cystathionine, protecting the endothelium from injury caused by hypoxia.	Homocysteine	61-64	cystathionine beta-synthase	Homo sapiens	29-32
30380942-3	2018	Cystathionine beta-synthase (CBS) plays an important role in Hcy homeostasis catalyzing the irreversible degradation of Hcy to cystathionine, protecting the endothelium from injury caused by hypoxia.	Cystathionine	127-140	cystathionine beta-synthase	Homo sapiens	0-27
30380942-3	2018	Cystathionine beta-synthase (CBS) plays an important role in Hcy homeostasis catalyzing the irreversible degradation of Hcy to cystathionine, protecting the endothelium from injury caused by hypoxia.	Cystathionine	127-140	cystathionine beta-synthase	Homo sapiens	29-32
30380942-4	2018	Several mutations and polymorphisms may alter the expression of the CBS gene, resulting in variable levels of Hcy.	Homocysteine	110-113	cystathionine beta-synthase	Homo sapiens	68-71
30396922-1	2018	BACKGROUND: Cystathione beta-synthase (CBS) catalyzes the conversion of homocysteine and cysteine to hydrogen sulfide (H2S) and cystathione, via the trans-sulfuration pathway.	Homocysteine	72-84	cystathionine beta-synthase	Homo sapiens	12-37
30396922-1	2018	BACKGROUND: Cystathione beta-synthase (CBS) catalyzes the conversion of homocysteine and cysteine to hydrogen sulfide (H2S) and cystathione, via the trans-sulfuration pathway.	Homocysteine	72-84	cystathionine beta-synthase	Homo sapiens	39-42
30396922-1	2018	BACKGROUND: Cystathione beta-synthase (CBS) catalyzes the conversion of homocysteine and cysteine to hydrogen sulfide (H2S) and cystathione, via the trans-sulfuration pathway.	Cysteine	76-84	cystathionine beta-synthase	Homo sapiens	12-37
30396922-1	2018	BACKGROUND: Cystathione beta-synthase (CBS) catalyzes the conversion of homocysteine and cysteine to hydrogen sulfide (H2S) and cystathione, via the trans-sulfuration pathway.	Cysteine	76-84	cystathionine beta-synthase	Homo sapiens	39-42
30396922-1	2018	BACKGROUND: Cystathione beta-synthase (CBS) catalyzes the conversion of homocysteine and cysteine to hydrogen sulfide (H2S) and cystathione, via the trans-sulfuration pathway.	Hydrogen Sulfide	101-117	cystathionine beta-synthase	Homo sapiens	12-37
30396922-1	2018	BACKGROUND: Cystathione beta-synthase (CBS) catalyzes the conversion of homocysteine and cysteine to hydrogen sulfide (H2S) and cystathione, via the trans-sulfuration pathway.	Hydrogen Sulfide	101-117	cystathionine beta-synthase	Homo sapiens	39-42
30396922-1	2018	BACKGROUND: Cystathione beta-synthase (CBS) catalyzes the conversion of homocysteine and cysteine to hydrogen sulfide (H2S) and cystathione, via the trans-sulfuration pathway.	Hydrogen Sulfide	119-122	cystathionine beta-synthase	Homo sapiens	12-37
30396922-1	2018	BACKGROUND: Cystathione beta-synthase (CBS) catalyzes the conversion of homocysteine and cysteine to hydrogen sulfide (H2S) and cystathione, via the trans-sulfuration pathway.	Hydrogen Sulfide	119-122	cystathionine beta-synthase	Homo sapiens	39-42
30396922-1	2018	BACKGROUND: Cystathione beta-synthase (CBS) catalyzes the conversion of homocysteine and cysteine to hydrogen sulfide (H2S) and cystathione, via the trans-sulfuration pathway.	Cystathionine	128-139	cystathionine beta-synthase	Homo sapiens	12-37
30396922-1	2018	BACKGROUND: Cystathione beta-synthase (CBS) catalyzes the conversion of homocysteine and cysteine to hydrogen sulfide (H2S) and cystathione, via the trans-sulfuration pathway.	Cystathionine	128-139	cystathionine beta-synthase	Homo sapiens	39-42
30408270-6	2019	The p.R336C knock-in HEK293T and HepG2 cells decreased the level of CBS expression and reduced its structural stability; however, treatment of the p.R336C knock-in HEK293T cells with betaine, a chemical chaperone, restored the stability and tetrameric conformation of CBS, but not its activity.	Betaine	183-190	cystathionine beta-synthase	Homo sapiens	68-71
30408270-6	2019	The p.R336C knock-in HEK293T and HepG2 cells decreased the level of CBS expression and reduced its structural stability; however, treatment of the p.R336C knock-in HEK293T cells with betaine, a chemical chaperone, restored the stability and tetrameric conformation of CBS, but not its activity.	Betaine	183-190	cystathionine beta-synthase	Homo sapiens	268-271
30566142-1	2019	Chelate-aryl and chelate-chelate stacking interactions of nickel bis(dithiolene) were studied at the CCSD(T)/CBS and DFT levels.	nickel bis(dithiolene)	58-80	cystathionine beta-synthase	Homo sapiens	109-112
30566142-2	2019	The strongest chelate-aryl stacking interaction between nickel bis(dithiolene) and benzene has a CCSD(T)/CBS stacking energy of -5.60 kcal mol-1.	nickel bis(dithiolene)	56-78	cystathionine beta-synthase	Homo sapiens	105-108
30566142-2	2019	The strongest chelate-aryl stacking interaction between nickel bis(dithiolene) and benzene has a CCSD(T)/CBS stacking energy of -5.60 kcal mol-1.	Benzene	83-90	cystathionine beta-synthase	Homo sapiens	105-108
30566142-3	2019	The strongest chelate-chelate stacking interactions between two nickel bis(dithiolenes) has a CCSD(T)/CBS stacking energy of -10.34 kcal mol-1.	nickel bis(dithiolenes)	64-87	cystathionine beta-synthase	Homo sapiens	102-105
30566142-6	2019	However, chelate-chelate stacking is stronger for dithiolene nickel chelate than for acac-type nickel chelate, which has a CCSD(T)/CBS interaction energy of -9.50 kcal mol-1.	dithiolene	50-60	cystathionine beta-synthase	Homo sapiens	131-134
30566142-6	2019	However, chelate-chelate stacking is stronger for dithiolene nickel chelate than for acac-type nickel chelate, which has a CCSD(T)/CBS interaction energy of -9.50 kcal mol-1.	acetylacetone	85-89	cystathionine beta-synthase	Homo sapiens	131-134
30566142-6	2019	However, chelate-chelate stacking is stronger for dithiolene nickel chelate than for acac-type nickel chelate, which has a CCSD(T)/CBS interaction energy of -9.50 kcal mol-1.	Nickel	61-67	cystathionine beta-synthase	Homo sapiens	131-134
30030379-4	2018	Here, we characterized a transgenic mouse model lacking endogenous Cbs and expressing human p.G307S CBS protein from a zinc-inducible metallothionein promoter (Tg-G307S Cbs-/-).	Thioguanine	160-162	cystathionine beta-synthase	Homo sapiens	169-172
30016218-6	2018	Knockdown of cystathionine-gamma-lyase (CSE) or cystathionine-beta-synthase (CBS), two main H2S-producing proteins, significantly diminished the increased expressions of EMT-related proteins induced by radiation through the p38MAPK pathway, leading to impaired invasion and metastasis of the residual HepG2 cells and their xenograft tumors.	Hydrogen Sulfide	92-95	cystathionine beta-synthase	Homo sapiens	48-75
30187703-2	2018	It is synthesized from cysteine by cystathionine gamma-lyase (CGL) and cystathionine beta-synthase (CBS).	Cysteine	23-31	cystathionine beta-synthase	Homo sapiens	100-103
30258181-1	2018	Cystathionine beta-synthase (CBS) is responsible for the first enzymatic reaction in the transsulfuration pathway of sulfur amino acids.	Amino Acids, Sulfur	117-135	cystathionine beta-synthase	Homo sapiens	0-27
30258181-1	2018	Cystathionine beta-synthase (CBS) is responsible for the first enzymatic reaction in the transsulfuration pathway of sulfur amino acids.	Amino Acids, Sulfur	117-135	cystathionine beta-synthase	Homo sapiens	29-32
30258181-3	2018	In the present study, we designed, synthesized and obtained a bioactive inhibitor CH004 for human CBS, which functions in vitro and in vivo.	ch004	82-87	cystathionine beta-synthase	Homo sapiens	98-101
30030379-4	2018	Here, we characterized a transgenic mouse model lacking endogenous Cbs and expressing human p.G307S CBS protein from a zinc-inducible metallothionein promoter (Tg-G307S Cbs-/-).	Thioguanine	160-162	cystathionine beta-synthase	Homo sapiens	100-103
30030379-6	2018	In a C3H/HeJ background, zinc-induced Tg-G307S Cbs-/- mice expressed high levels of p.G307S CBS in the liver, and this protein variant forms multimers, similarly to mice expressing WT human CBS.	Thioguanine	38-40	cystathionine beta-synthase	Homo sapiens	190-193
30283315-4	2018	Since recent studies have demonstrated that several human tumors overexpress the hydrogen sulfide (H2S)-synthesizing enzymes cystathionine-beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST), and also show dysregulated H2S levels, we examined these biomarkers in the oral ACC and compared the results to those of adjacent benign oral epithelium.	Hydrogen Sulfide	81-97	cystathionine beta-synthase	Homo sapiens	125-152
30254695-2	2018	The synthetic procedure comprised the stereoselective reduction of a ketone functionality in an ene-yne-one employing CBS as a catalyst and a Cadiot-Chodkiewicz coupling reaction as the key reaction steps.	Ketones	69-75	cystathionine beta-synthase	Homo sapiens	118-121
29859343-4	2018	The sources of such reactive species include NADPH oxidases (NOXs), the mitochondrial electron transport chain, nitric oxide synthases, nitrite reductases, and the hydrogen sulfide producing enzymes cystathionine-beta synthase and cystathionine-gamma lyase.	Hydrogen Sulfide	164-180	cystathionine beta-synthase	Homo sapiens	199-226
30283315-4	2018	Since recent studies have demonstrated that several human tumors overexpress the hydrogen sulfide (H2S)-synthesizing enzymes cystathionine-beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST), and also show dysregulated H2S levels, we examined these biomarkers in the oral ACC and compared the results to those of adjacent benign oral epithelium.	Hydrogen Sulfide	81-97	cystathionine beta-synthase	Homo sapiens	154-157
30283315-4	2018	Since recent studies have demonstrated that several human tumors overexpress the hydrogen sulfide (H2S)-synthesizing enzymes cystathionine-beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST), and also show dysregulated H2S levels, we examined these biomarkers in the oral ACC and compared the results to those of adjacent benign oral epithelium.	Hydrogen Sulfide	99-102	cystathionine beta-synthase	Homo sapiens	125-152
30283315-4	2018	Since recent studies have demonstrated that several human tumors overexpress the hydrogen sulfide (H2S)-synthesizing enzymes cystathionine-beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST), and also show dysregulated H2S levels, we examined these biomarkers in the oral ACC and compared the results to those of adjacent benign oral epithelium.	Hydrogen Sulfide	99-102	cystathionine beta-synthase	Homo sapiens	154-157
30050925-1	2018	Cystathionine beta-synthase (CBS) regulates homocysteine metabolism and contributes to hydrogen sulfide (H2S) biosynthesis through which it plays multifunctional roles in the regulation of cellular energetics, redox status, DNA methylation, and protein modification.	Hydrogen Sulfide	87-103	cystathionine beta-synthase	Homo sapiens	0-27
30283315-4	2018	Since recent studies have demonstrated that several human tumors overexpress the hydrogen sulfide (H2S)-synthesizing enzymes cystathionine-beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST), and also show dysregulated H2S levels, we examined these biomarkers in the oral ACC and compared the results to those of adjacent benign oral epithelium.	Hydrogen Sulfide	270-273	cystathionine beta-synthase	Homo sapiens	125-152
29494264-7	2018	Supplementation with hydrogen sulfide or glutathione (the catalytic products of CBS enzymatic activity), anti-oxidants, or a JNK inhibitor restores MFN2 expression.	Hydrogen Sulfide	21-37	cystathionine beta-synthase	Homo sapiens	80-83
29494264-7	2018	Supplementation with hydrogen sulfide or glutathione (the catalytic products of CBS enzymatic activity), anti-oxidants, or a JNK inhibitor restores MFN2 expression.	Glutathione	41-52	cystathionine beta-synthase	Homo sapiens	80-83
30050925-1	2018	Cystathionine beta-synthase (CBS) regulates homocysteine metabolism and contributes to hydrogen sulfide (H2S) biosynthesis through which it plays multifunctional roles in the regulation of cellular energetics, redox status, DNA methylation, and protein modification.	Hydrogen Sulfide	87-103	cystathionine beta-synthase	Homo sapiens	29-32
30050925-1	2018	Cystathionine beta-synthase (CBS) regulates homocysteine metabolism and contributes to hydrogen sulfide (H2S) biosynthesis through which it plays multifunctional roles in the regulation of cellular energetics, redox status, DNA methylation, and protein modification.	Hydrogen Sulfide	105-108	cystathionine beta-synthase	Homo sapiens	0-27
30050925-1	2018	Cystathionine beta-synthase (CBS) regulates homocysteine metabolism and contributes to hydrogen sulfide (H2S) biosynthesis through which it plays multifunctional roles in the regulation of cellular energetics, redox status, DNA methylation, and protein modification.	Hydrogen Sulfide	105-108	cystathionine beta-synthase	Homo sapiens	29-32
29634343-4	2018	CRITICAL ISSUES: Here, we discuss the role of dietary SAAs and growth hormone (GH)/thyroid hormone (TH) signaling in regulation of endogenous H2S production largely via repression of H2S generating enzymes cystathionine gamma-lyase (CGL) and cystathionine beta-synthase (CBS) on the level of gene transcription, as well as reciprocal regulation of GH and TH signaling by H2S itself.	Hydrogen Sulfide	142-145	cystathionine beta-synthase	Homo sapiens	242-269
28537489-4	2018	RESULTS: We found that both subfertile and infertile patients, especially asthenospermic patients, exhibited decreased concentration of H2S in their seminal plasma and diminished expression of H2S-generating enzyme (cystathionine beta-synthase [CBS]) in sperm.	Hydrogen Sulfide	193-196	cystathionine beta-synthase	Homo sapiens	216-243
29357418-2	2018	Hydrogen sulfide (H2S) generated by cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE) facilitates bladder hypersensitivity.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	36-63
29357418-2	2018	Hydrogen sulfide (H2S) generated by cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE) facilitates bladder hypersensitivity.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	36-63
29634343-4	2018	CRITICAL ISSUES: Here, we discuss the role of dietary SAAs and growth hormone (GH)/thyroid hormone (TH) signaling in regulation of endogenous H2S production largely via repression of H2S generating enzymes cystathionine gamma-lyase (CGL) and cystathionine beta-synthase (CBS) on the level of gene transcription, as well as reciprocal regulation of GH and TH signaling by H2S itself.	Hydrogen Sulfide	142-145	cystathionine beta-synthase	Homo sapiens	271-274
29658603-6	2018	We found that H2S production was markedly decreased in A549/DDP cells compared with that in A549 cells, accomplished by the downregulation of cystathionine beta-synthase (CBS), an endogenous H2S-producing enzyme.	Hydrogen Sulfide	14-17	cystathionine beta-synthase	Homo sapiens	142-169
28777022-1	2018	OBJECTIVE Cystathionine beta-synthase (CBS) is involved in homocysteine and hydrogen sulfide (H2S) metabolism.	Homocysteine	59-71	cystathionine beta-synthase	Homo sapiens	10-37
28777022-1	2018	OBJECTIVE Cystathionine beta-synthase (CBS) is involved in homocysteine and hydrogen sulfide (H2S) metabolism.	Homocysteine	59-71	cystathionine beta-synthase	Homo sapiens	39-42
28777022-1	2018	OBJECTIVE Cystathionine beta-synthase (CBS) is involved in homocysteine and hydrogen sulfide (H2S) metabolism.	Hydrogen Sulfide	76-92	cystathionine beta-synthase	Homo sapiens	10-37
28777022-1	2018	OBJECTIVE Cystathionine beta-synthase (CBS) is involved in homocysteine and hydrogen sulfide (H2S) metabolism.	Hydrogen Sulfide	76-92	cystathionine beta-synthase	Homo sapiens	39-42
28777022-1	2018	OBJECTIVE Cystathionine beta-synthase (CBS) is involved in homocysteine and hydrogen sulfide (H2S) metabolism.	Hydrogen Sulfide	94-97	cystathionine beta-synthase	Homo sapiens	10-37
28777022-1	2018	OBJECTIVE Cystathionine beta-synthase (CBS) is involved in homocysteine and hydrogen sulfide (H2S) metabolism.	Hydrogen Sulfide	94-97	cystathionine beta-synthase	Homo sapiens	39-42
28777022-12	2018	Increased CBS activity may exert its neuroprotective effects through alteration of H2S levels, and independent of clinical vasospasm and DCI.	Hydrogen Sulfide	83-86	cystathionine beta-synthase	Homo sapiens	10-13
29658603-6	2018	We found that H2S production was markedly decreased in A549/DDP cells compared with that in A549 cells, accomplished by the downregulation of cystathionine beta-synthase (CBS), an endogenous H2S-producing enzyme.	Hydrogen Sulfide	191-194	cystathionine beta-synthase	Homo sapiens	142-169
29745664-0	2018	Toward High-Level Theoretical Studies of Large Biodiesel Molecules: An ONIOM [QCISD(T)/CBS:DFT] Study of the Reactions between Unsaturated Methyl Esters (C nH2 n-1COOCH3) and Hydrogen Radical.	unsaturated methyl esters	127-152	cystathionine beta-synthase	Homo sapiens	87-90
29928321-1	2018	H2S, synthesized by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (MPST), functions as a signalling molecule in mammalian cells.	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	20-47
29928321-1	2018	H2S, synthesized by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (MPST), functions as a signalling molecule in mammalian cells.	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	49-52
29745664-1	2018	A two-layer ONIOM[QCISD(T)/CBS:DFT] method was proposed for the high-level single-point energy calculations of large biodiesel molecules and was validated for the hydrogen abstraction reactions of unsaturated methyl esters that are important components of real biodiesel.	Hydrogen	163-171	cystathionine beta-synthase	Homo sapiens	27-30
29745664-1	2018	A two-layer ONIOM[QCISD(T)/CBS:DFT] method was proposed for the high-level single-point energy calculations of large biodiesel molecules and was validated for the hydrogen abstraction reactions of unsaturated methyl esters that are important components of real biodiesel.	unsaturated methyl esters	197-222	cystathionine beta-synthase	Homo sapiens	27-30
29922024-1	2018	Homocystinuria is a genetic inborn error of metabolism due to the deficiency of cystathionine beta-synthase resulting in increased serum homocysteine and methionine and decreased cysteine which predisposes affected individuals to arterial and venous thromboembolic phenomena.	Homocysteine	137-149	cystathionine beta-synthase	Homo sapiens	80-107
29745942-5	2018	The strongest antiparallel chelate-chelate stacking interaction is formed between two platinum chelates, with a CCSD(T)/CBS interaction energy of -9.70 kcal mol-1, while the strongest stacking between two palladium chelates and two nickel chelates has CCSD(T)/CBS energies of -9.21 kcal mol-1 and -9.50 kcal mol-1, respectively.	Platinum	86-94	cystathionine beta-synthase	Homo sapiens	120-123
29745942-5	2018	The strongest antiparallel chelate-chelate stacking interaction is formed between two platinum chelates, with a CCSD(T)/CBS interaction energy of -9.70 kcal mol-1, while the strongest stacking between two palladium chelates and two nickel chelates has CCSD(T)/CBS energies of -9.21 kcal mol-1 and -9.50 kcal mol-1, respectively.	Platinum	86-94	cystathionine beta-synthase	Homo sapiens	260-263
29745942-5	2018	The strongest antiparallel chelate-chelate stacking interaction is formed between two platinum chelates, with a CCSD(T)/CBS interaction energy of -9.70 kcal mol-1, while the strongest stacking between two palladium chelates and two nickel chelates has CCSD(T)/CBS energies of -9.21 kcal mol-1 and -9.50 kcal mol-1, respectively.	Palladium	205-214	cystathionine beta-synthase	Homo sapiens	120-123
29745942-5	2018	The strongest antiparallel chelate-chelate stacking interaction is formed between two platinum chelates, with a CCSD(T)/CBS interaction energy of -9.70 kcal mol-1, while the strongest stacking between two palladium chelates and two nickel chelates has CCSD(T)/CBS energies of -9.21 kcal mol-1 and -9.50 kcal mol-1, respectively.	Palladium	205-214	cystathionine beta-synthase	Homo sapiens	260-263
29745942-5	2018	The strongest antiparallel chelate-chelate stacking interaction is formed between two platinum chelates, with a CCSD(T)/CBS interaction energy of -9.70 kcal mol-1, while the strongest stacking between two palladium chelates and two nickel chelates has CCSD(T)/CBS energies of -9.21 kcal mol-1 and -9.50 kcal mol-1, respectively.	Nickel	232-238	cystathionine beta-synthase	Homo sapiens	120-123
29793450-1	2018	BACKGROUND: Knowledge about the expression and thus a role of enzymes that produce endogenous H2S - cystathionine-beta-synthase, cystathionine gamma-lyase and mercaptopyruvate sulfurtransferase - in renal tumors is still controversial.	Hydrogen Sulfide	94-97	cystathionine beta-synthase	Homo sapiens	100-127
29722396-1	2018	Quantum chemical calculations at the CCSD(T)/CBS//MP2/aug-cc-pVTZ levels of theory have been carried out to investigate a potential new source of acetamide in Earth"s atmosphere through the ammonolysis of the simplest ketene.	acetamide	146-155	cystathionine beta-synthase	Homo sapiens	45-48
29732408-5	2018	Silencing cystathionine beta-synthase (CBS) prevents closure, suggesting that this enzyme is the main source of H2S.	Hydrogen Sulfide	112-115	cystathionine beta-synthase	Homo sapiens	10-37
29922024-1	2018	Homocystinuria is a genetic inborn error of metabolism due to the deficiency of cystathionine beta-synthase resulting in increased serum homocysteine and methionine and decreased cysteine which predisposes affected individuals to arterial and venous thromboembolic phenomena.	Methionine	154-164	cystathionine beta-synthase	Homo sapiens	80-107
29922024-1	2018	Homocystinuria is a genetic inborn error of metabolism due to the deficiency of cystathionine beta-synthase resulting in increased serum homocysteine and methionine and decreased cysteine which predisposes affected individuals to arterial and venous thromboembolic phenomena.	Cysteine	141-149	cystathionine beta-synthase	Homo sapiens	80-107
29452248-1	2018	Hydrogen sulfide (H2S) is produced by the action of cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) or 3-mercaptopyruvate sulfurtransferase (3-MST).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	52-79
29526799-1	2018	AIMS: PEGylated human truncated cystathionine beta-synthase, lacking the C-terminal regulatory domain (PEG-CBS), is a promising preclinical candidate for enzyme replacement therapy in homocystinuria (HCU).	Polyethylene Glycols	6-9	cystathionine beta-synthase	Homo sapiens	32-59
29452248-1	2018	Hydrogen sulfide (H2S) is produced by the action of cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) or 3-mercaptopyruvate sulfurtransferase (3-MST).	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	52-79
29505687-2	2018	However, the singlet forms a strong donor-acceptor bond to argon with a bond energy of 66.4 kcal mol-1 at the CCSDT(Q)/CBS level, making the singlet ArOH+ cation 3.9 kcal mol-1 more stable than the lowest energy triplet complex.	singlet	13-20	cystathionine beta-synthase	Homo sapiens	119-122
29505687-2	2018	However, the singlet forms a strong donor-acceptor bond to argon with a bond energy of 66.4 kcal mol-1 at the CCSDT(Q)/CBS level, making the singlet ArOH+ cation 3.9 kcal mol-1 more stable than the lowest energy triplet complex.	Argon	59-64	cystathionine beta-synthase	Homo sapiens	119-122
29505687-2	2018	However, the singlet forms a strong donor-acceptor bond to argon with a bond energy of 66.4 kcal mol-1 at the CCSDT(Q)/CBS level, making the singlet ArOH+ cation 3.9 kcal mol-1 more stable than the lowest energy triplet complex.	singlet aroh	141-153	cystathionine beta-synthase	Homo sapiens	119-122
29453981-0	2018	The C2"- and C3"-endo equilibrium for AMP molecules bound in the cystathionine-beta-synthase domain.	Adenosine Monophosphate	38-41	cystathionine beta-synthase	Homo sapiens	65-92
29275181-6	2018	In addition, comparison of available CBS structures unveils a substrate-induced closure of the catalytic cavity, which in humans is affected by the AdoMet-dependent regulation and likely impaired by the homocystinuria causing mutation T191M.	S-Adenosylmethionine	148-154	cystathionine beta-synthase	Homo sapiens	37-40
29453981-3	2018	We observed two AMP molecules, in C3"- and C2"-endo conformations respectively, simultaneously bound to a cystathionine-beta-synthase (CBS) domain dimer of the magnesium and cobalt efflux protein CorC in the crystallographic study.	Adenosine Monophosphate	16-19	cystathionine beta-synthase	Homo sapiens	106-133
29453981-3	2018	We observed two AMP molecules, in C3"- and C2"-endo conformations respectively, simultaneously bound to a cystathionine-beta-synthase (CBS) domain dimer of the magnesium and cobalt efflux protein CorC in the crystallographic study.	Magnesium	160-169	cystathionine beta-synthase	Homo sapiens	106-133
28486919-4	2018	Cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) play a crucial role in metabolizing Hcy to cysteine through the transsulfuration pathway.	Cysteine	113-121	cystathionine beta-synthase	Homo sapiens	0-27
29061341-8	2018	Two major H2S-generating enzymes, cystathionine-beta-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST) were upregulated in the 5-FU-resistant cells.	Hydrogen Sulfide	10-13	cystathionine beta-synthase	Homo sapiens	34-61
29061341-8	2018	Two major H2S-generating enzymes, cystathionine-beta-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST) were upregulated in the 5-FU-resistant cells.	Hydrogen Sulfide	10-13	cystathionine beta-synthase	Homo sapiens	63-66
29061341-9	2018	5-FU-resistant cells exhibited decreased sensitivity to the CBS inhibitor aminooxyacetate (AOAA) in terms of suppression of cell viability, inhibition of cell proliferation and inhibition of oxidative phosphorylation.	Fluorouracil	0-4	cystathionine beta-synthase	Homo sapiens	60-63
29061341-9	2018	5-FU-resistant cells exhibited decreased sensitivity to the CBS inhibitor aminooxyacetate (AOAA) in terms of suppression of cell viability, inhibition of cell proliferation and inhibition of oxidative phosphorylation.	Aminooxyacetic Acid	74-89	cystathionine beta-synthase	Homo sapiens	60-63
29061341-9	2018	5-FU-resistant cells exhibited decreased sensitivity to the CBS inhibitor aminooxyacetate (AOAA) in terms of suppression of cell viability, inhibition of cell proliferation and inhibition of oxidative phosphorylation.	Aminooxyacetic Acid	91-95	cystathionine beta-synthase	Homo sapiens	60-63
29061341-10	2018	However, 5FU-resistant cells remained sensitive to the antiproliferative effect of benserazide (a recently identified, potentially repurposable CBS inhibitor).	Benserazide	83-94	cystathionine beta-synthase	Homo sapiens	144-147
29410458-0	2018	Heme interaction of the intrinsically disordered N-terminal peptide segment of human cystathionine-beta-synthase.	Heme	0-4	cystathionine beta-synthase	Homo sapiens	85-112
29410458-1	2018	Cystathionine-beta-synthase (CBS) belongs to a large family of pyridoxal 5"-phosphate (PLP)-dependent enzymes, responsible for the sulfur metabolism.	Sulfur	131-137	cystathionine beta-synthase	Homo sapiens	0-27
29410458-1	2018	Cystathionine-beta-synthase (CBS) belongs to a large family of pyridoxal 5"-phosphate (PLP)-dependent enzymes, responsible for the sulfur metabolism.	Sulfur	131-137	cystathionine beta-synthase	Homo sapiens	29-32
29410458-2	2018	The heme-dependent protein CBS is part of regulatory pathways also involving the gasotransmitter hydrogen sulfide.	Hydrogen Sulfide	97-113	cystathionine beta-synthase	Homo sapiens	27-30
29410458-5	2018	Here we report the NMR resonance assignment and heme interaction studies for the N-terminal peptide stretch of CBS.	Heme	48-52	cystathionine beta-synthase	Homo sapiens	111-114
29410458-6	2018	We present NMR-spectral evidence that residues 1-40 constitute an intrinsically disordered region in CBS and interact with heme via a cysteine-proline based motif.	Heme	123-127	cystathionine beta-synthase	Homo sapiens	101-104
29410458-6	2018	We present NMR-spectral evidence that residues 1-40 constitute an intrinsically disordered region in CBS and interact with heme via a cysteine-proline based motif.	Cysteine	134-142	cystathionine beta-synthase	Homo sapiens	101-104
29410458-6	2018	We present NMR-spectral evidence that residues 1-40 constitute an intrinsically disordered region in CBS and interact with heme via a cysteine-proline based motif.	Proline	143-150	cystathionine beta-synthase	Homo sapiens	101-104
28874062-0	2018	Biogenesis of Hydrogen Sulfide and Thioethers by Cystathionine Beta-Synthase.	Hydrogen Sulfide	14-30	cystathionine beta-synthase	Homo sapiens	49-76
28874062-0	2018	Biogenesis of Hydrogen Sulfide and Thioethers by Cystathionine Beta-Synthase.	Sulfides	35-45	cystathionine beta-synthase	Homo sapiens	49-76
28874062-1	2018	AIMS: The transsulfuration pathway enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase are thought to be the major source of hydrogen sulfide (H2S).	Hydrogen Sulfide	145-161	cystathionine beta-synthase	Homo sapiens	43-70
28874062-1	2018	AIMS: The transsulfuration pathway enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase are thought to be the major source of hydrogen sulfide (H2S).	Hydrogen Sulfide	145-161	cystathionine beta-synthase	Homo sapiens	72-75
28874062-1	2018	AIMS: The transsulfuration pathway enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase are thought to be the major source of hydrogen sulfide (H2S).	Hydrogen Sulfide	163-166	cystathionine beta-synthase	Homo sapiens	43-70
28874062-1	2018	AIMS: The transsulfuration pathway enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase are thought to be the major source of hydrogen sulfide (H2S).	Hydrogen Sulfide	163-166	cystathionine beta-synthase	Homo sapiens	72-75
28874062-2	2018	In this study, we assessed the role of CBS in H2S biogenesis.	Hydrogen Sulfide	46-49	cystathionine beta-synthase	Homo sapiens	39-42
28874062-3	2018	RESULTS: We show that despite discouraging enzyme kinetics of alternative H2S-producing reactions utilizing cysteine compared with the canonical condensation of serine and homocysteine, our simulations of substrate competitions at biologically relevant conditions suggest that cysteine is able to partially compete with serine on CBS, thus leading to generation of appreciable amounts of H2S.	Hydrogen Sulfide	74-77	cystathionine beta-synthase	Homo sapiens	330-333
28874062-5	2018	We found that the serine-to-cysteine ratio is the main determinant of CBS H2S productivity.	Serine	18-24	cystathionine beta-synthase	Homo sapiens	70-73
28874062-5	2018	We found that the serine-to-cysteine ratio is the main determinant of CBS H2S productivity.	Cysteine	28-36	cystathionine beta-synthase	Homo sapiens	70-73
28874062-5	2018	We found that the serine-to-cysteine ratio is the main determinant of CBS H2S productivity.	Hydrogen Sulfide	74-77	cystathionine beta-synthase	Homo sapiens	70-73
28874062-6	2018	Abundance of cysteine over serine, for example, in plasma, allowed for up to 43% of CBS activity being responsible for H2S production, while excess of serine typical for intracellular levels effectively limited such activity to less than 1.5%.	Cysteine	13-21	cystathionine beta-synthase	Homo sapiens	84-87
28874062-6	2018	Abundance of cysteine over serine, for example, in plasma, allowed for up to 43% of CBS activity being responsible for H2S production, while excess of serine typical for intracellular levels effectively limited such activity to less than 1.5%.	Serine	27-33	cystathionine beta-synthase	Homo sapiens	84-87
28486919-4	2018	Cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) play a crucial role in metabolizing Hcy to cysteine through the transsulfuration pathway.	Homocysteine	106-109	cystathionine beta-synthase	Homo sapiens	0-27
28689885-0	2018	Reduction of hydrogen sulfide synthesis enzymes cystathionine-beta-synthase and cystathionine-gamma-lyase in the colon of patients with Hirschsprungs disease.	Hydrogen Sulfide	13-29	cystathionine beta-synthase	Homo sapiens	48-75
28689885-4	2018	Hydrogen sulfide, synthesized from L-cysteine by two key enzymes, cystathionine-beta-synthase (CBS) and cystathionine-gamma-lysase (CSE) is reported to play a key role in regulating gastrointestinal motility and promoting resolution of inflammation.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	66-93
28689885-4	2018	Hydrogen sulfide, synthesized from L-cysteine by two key enzymes, cystathionine-beta-synthase (CBS) and cystathionine-gamma-lysase (CSE) is reported to play a key role in regulating gastrointestinal motility and promoting resolution of inflammation.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	95-98
28689885-4	2018	Hydrogen sulfide, synthesized from L-cysteine by two key enzymes, cystathionine-beta-synthase (CBS) and cystathionine-gamma-lysase (CSE) is reported to play a key role in regulating gastrointestinal motility and promoting resolution of inflammation.	Cysteine	35-45	cystathionine beta-synthase	Homo sapiens	66-93
28689885-4	2018	Hydrogen sulfide, synthesized from L-cysteine by two key enzymes, cystathionine-beta-synthase (CBS) and cystathionine-gamma-lysase (CSE) is reported to play a key role in regulating gastrointestinal motility and promoting resolution of inflammation.	Cysteine	35-45	cystathionine beta-synthase	Homo sapiens	95-98
29298893-0	2018	Allosteric control of human cystathionine beta-synthase activity by a redox active disulfide bond.	Disulfides	83-92	cystathionine beta-synthase	Homo sapiens	28-55
29298893-1	2018	Cystathionine beta-synthase (CBS) is the central enzyme in the trans-sulfuration pathway that converts homocysteine to cysteine.	Homocysteine	103-115	cystathionine beta-synthase	Homo sapiens	0-27
29298893-1	2018	Cystathionine beta-synthase (CBS) is the central enzyme in the trans-sulfuration pathway that converts homocysteine to cysteine.	Homocysteine	103-115	cystathionine beta-synthase	Homo sapiens	29-32
29298893-1	2018	Cystathionine beta-synthase (CBS) is the central enzyme in the trans-sulfuration pathway that converts homocysteine to cysteine.	Cysteine	107-115	cystathionine beta-synthase	Homo sapiens	0-27
29298893-1	2018	Cystathionine beta-synthase (CBS) is the central enzyme in the trans-sulfuration pathway that converts homocysteine to cysteine.	Cysteine	107-115	cystathionine beta-synthase	Homo sapiens	29-32
29298893-5	2018	The activity of reduced CBS is ~2-3-fold greater than that of the oxidized enzyme, and substitution of either cysteine in CXXC motif leads to a loss of redox sensitivity.	Cysteine	110-118	cystathionine beta-synthase	Homo sapiens	24-27
29298893-6	2018	The Cys272-Cys275 disulfide bond in CBS has a midpoint potential of -314 mV at pH 7.4.	Disulfides	18-27	cystathionine beta-synthase	Homo sapiens	36-39
29298893-8	2018	By contrast, incubation of cells with aminooxyacetic acid, an inhibitor of CBS and cystathionine gamma-lyase, eliminated the increase of H2S production after the cells were exposed to DTT.	Aminooxyacetic Acid	38-57	cystathionine beta-synthase	Homo sapiens	75-78
29298893-8	2018	By contrast, incubation of cells with aminooxyacetic acid, an inhibitor of CBS and cystathionine gamma-lyase, eliminated the increase of H2S production after the cells were exposed to DTT.	Hydrogen Sulfide	137-140	cystathionine beta-synthase	Homo sapiens	75-78
29298893-8	2018	By contrast, incubation of cells with aminooxyacetic acid, an inhibitor of CBS and cystathionine gamma-lyase, eliminated the increase of H2S production after the cells were exposed to DTT.	Dithiothreitol	184-187	cystathionine beta-synthase	Homo sapiens	75-78
29298893-9	2018	These findings indicate that CBS is post-translationally regulated by a redox-active disulfide bond in the CXXC motif.	Disulfides	85-94	cystathionine beta-synthase	Homo sapiens	29-32
29298893-10	2018	The results also demonstrate that CBS-derived H2S production is increased in cells under reductive stress conditions.	Hydrogen Sulfide	46-49	cystathionine beta-synthase	Homo sapiens	34-37
29507650-2	2018	H2S is produced from cysteine by enzymes, such as cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), cysteine aminotransferase (CAT), and 3-mercaptopyruvate sulfurtransferase (3MST).	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	50-77
29507650-2	2018	H2S is produced from cysteine by enzymes, such as cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), cysteine aminotransferase (CAT), and 3-mercaptopyruvate sulfurtransferase (3MST).	Cysteine	21-29	cystathionine beta-synthase	Homo sapiens	50-77
28874062-6	2018	Abundance of cysteine over serine, for example, in plasma, allowed for up to 43% of CBS activity being responsible for H2S production, while excess of serine typical for intracellular levels effectively limited such activity to less than 1.5%.	Hydrogen Sulfide	119-122	cystathionine beta-synthase	Homo sapiens	84-87
28874062-7	2018	CBS also produced lanthionine from serine and cysteine and a third of lanthionine coming from condensation of two cysteines contributed to the H2S pool.	lanthionine	18-29	cystathionine beta-synthase	Homo sapiens	0-3
28874062-7	2018	CBS also produced lanthionine from serine and cysteine and a third of lanthionine coming from condensation of two cysteines contributed to the H2S pool.	Serine	35-41	cystathionine beta-synthase	Homo sapiens	0-3
28874062-7	2018	CBS also produced lanthionine from serine and cysteine and a third of lanthionine coming from condensation of two cysteines contributed to the H2S pool.	Cysteine	46-54	cystathionine beta-synthase	Homo sapiens	0-3
28874062-7	2018	CBS also produced lanthionine from serine and cysteine and a third of lanthionine coming from condensation of two cysteines contributed to the H2S pool.	lanthionine	70-81	cystathionine beta-synthase	Homo sapiens	0-3
28874062-7	2018	CBS also produced lanthionine from serine and cysteine and a third of lanthionine coming from condensation of two cysteines contributed to the H2S pool.	Hydrogen Sulfide	143-146	cystathionine beta-synthase	Homo sapiens	0-3
28874062-8	2018	INNOVATION: Our study characterizes the H2S-producing potential of CBS under biologically relevant conditions and highlights the serine-to-cysteine ratio as the main determinant of H2S production by CBS in vivo.	Hydrogen Sulfide	40-43	cystathionine beta-synthase	Homo sapiens	67-70
28874062-8	2018	INNOVATION: Our study characterizes the H2S-producing potential of CBS under biologically relevant conditions and highlights the serine-to-cysteine ratio as the main determinant of H2S production by CBS in vivo.	Hydrogen Sulfide	40-43	cystathionine beta-synthase	Homo sapiens	199-202
28874062-8	2018	INNOVATION: Our study characterizes the H2S-producing potential of CBS under biologically relevant conditions and highlights the serine-to-cysteine ratio as the main determinant of H2S production by CBS in vivo.	Serine	129-135	cystathionine beta-synthase	Homo sapiens	67-70
28874062-8	2018	INNOVATION: Our study characterizes the H2S-producing potential of CBS under biologically relevant conditions and highlights the serine-to-cysteine ratio as the main determinant of H2S production by CBS in vivo.	Serine	129-135	cystathionine beta-synthase	Homo sapiens	199-202
28874062-8	2018	INNOVATION: Our study characterizes the H2S-producing potential of CBS under biologically relevant conditions and highlights the serine-to-cysteine ratio as the main determinant of H2S production by CBS in vivo.	Cysteine	139-147	cystathionine beta-synthase	Homo sapiens	67-70
28874062-8	2018	INNOVATION: Our study characterizes the H2S-producing potential of CBS under biologically relevant conditions and highlights the serine-to-cysteine ratio as the main determinant of H2S production by CBS in vivo.	Cysteine	139-147	cystathionine beta-synthase	Homo sapiens	199-202
28874062-8	2018	INNOVATION: Our study characterizes the H2S-producing potential of CBS under biologically relevant conditions and highlights the serine-to-cysteine ratio as the main determinant of H2S production by CBS in vivo.	Hydrogen Sulfide	181-184	cystathionine beta-synthase	Homo sapiens	67-70
28874062-8	2018	INNOVATION: Our study characterizes the H2S-producing potential of CBS under biologically relevant conditions and highlights the serine-to-cysteine ratio as the main determinant of H2S production by CBS in vivo.	Hydrogen Sulfide	181-184	cystathionine beta-synthase	Homo sapiens	199-202
28874062-9	2018	CONCLUSION: Our data clarify the function of CBS in H2S biogenesis and the role of thioethers as surrogate H2S markers.	Hydrogen Sulfide	52-55	cystathionine beta-synthase	Homo sapiens	45-48
29261311-3	2018	Multiplets using mixed isotopic cyanogens reveal the stoichiometries of these products, and the band positions and quantum chemical calculations confirm the isocyanide bonding arrangements, which are 14 and 51 kJ/mol more stable than the cyanide isomers for UNC and U(NC)2, respectively, and 62 kJ/mol for U(NC)4 in the isolated gas phase at the CCSD(T)/CBS level.	Cyanides	157-167	cystathionine beta-synthase	Homo sapiens	354-357
29261311-3	2018	Multiplets using mixed isotopic cyanogens reveal the stoichiometries of these products, and the band positions and quantum chemical calculations confirm the isocyanide bonding arrangements, which are 14 and 51 kJ/mol more stable than the cyanide isomers for UNC and U(NC)2, respectively, and 62 kJ/mol for U(NC)4 in the isolated gas phase at the CCSD(T)/CBS level.	Cyanides	160-167	cystathionine beta-synthase	Homo sapiens	354-357
29249255-2	2018	Prior studies identified hydrogen sulfide-generating enzymes cystathionine-beta-synthetase (CBS) and cystathionine-gamma-lyase (CSE) in fetal membranes.	Hydrogen Sulfide	25-41	cystathionine beta-synthase	Homo sapiens	61-90
29018979-2	2018	Several studies have been carried out to evaluate the effects of a diet inducing cystathionine-beta-synthase, methyltetrafolate, folic acid, and vitamin B supplemented with methionine on the homocysteine metabolism and in lowering the plasma total homocysteine levels.	Homocysteine	191-203	cystathionine beta-synthase	Homo sapiens	81-108
29779029-11	2018	The mRNA levels of cystathionine beta-synthase and cystathionine gamma-lyase, 2 catalytic enzymes of H2S formation, were significantly lower in blood mononuclear cells of CKD patients with respect to controls; however, the mRNA level of 3-mercaptopyruvate sulfurtransferase, as another H2S-producing enzyme, was significantly higher in CKD patients.	Deuterium	101-104	cystathionine beta-synthase	Homo sapiens	19-46
29779029-11	2018	The mRNA levels of cystathionine beta-synthase and cystathionine gamma-lyase, 2 catalytic enzymes of H2S formation, were significantly lower in blood mononuclear cells of CKD patients with respect to controls; however, the mRNA level of 3-mercaptopyruvate sulfurtransferase, as another H2S-producing enzyme, was significantly higher in CKD patients.	Deuterium	286-289	cystathionine beta-synthase	Homo sapiens	19-46
28774789-6	2018	The in vitro study confirmed a significant decrease of CBS expression in 1-methyl-4-phenylpyridinium (MPP+)-stimulated astrocytes and microglia, but not in neurons or SH-SY5Y dopaminergic cells.	1-Methyl-4-phenylpyridinium	73-100	cystathionine beta-synthase	Homo sapiens	55-58
28774789-6	2018	The in vitro study confirmed a significant decrease of CBS expression in 1-methyl-4-phenylpyridinium (MPP+)-stimulated astrocytes and microglia, but not in neurons or SH-SY5Y dopaminergic cells.	mangion-purified polysaccharide (Candida albicans)	102-106	cystathionine beta-synthase	Homo sapiens	55-58
28774789-7	2018	Striatal CBS overexpression, elicited by stereotaxic delivery with Cbs gene using recombinant adeno-associated-virus (rAAV-Cbs), successfully enhanced the sulfide level in the striatum and partially rescued the MPTP-induced dopaminergic neurotoxicity in the midbrain.	Sulfides	155-162	cystathionine beta-synthase	Homo sapiens	9-12
28774789-7	2018	Striatal CBS overexpression, elicited by stereotaxic delivery with Cbs gene using recombinant adeno-associated-virus (rAAV-Cbs), successfully enhanced the sulfide level in the striatum and partially rescued the MPTP-induced dopaminergic neurotoxicity in the midbrain.	Sulfides	155-162	cystathionine beta-synthase	Homo sapiens	67-70
28774789-7	2018	Striatal CBS overexpression, elicited by stereotaxic delivery with Cbs gene using recombinant adeno-associated-virus (rAAV-Cbs), successfully enhanced the sulfide level in the striatum and partially rescued the MPTP-induced dopaminergic neurotoxicity in the midbrain.	Sulfides	155-162	cystathionine beta-synthase	Homo sapiens	123-126
28774789-7	2018	Striatal CBS overexpression, elicited by stereotaxic delivery with Cbs gene using recombinant adeno-associated-virus (rAAV-Cbs), successfully enhanced the sulfide level in the striatum and partially rescued the MPTP-induced dopaminergic neurotoxicity in the midbrain.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	211-215	cystathionine beta-synthase	Homo sapiens	9-12
28774789-7	2018	Striatal CBS overexpression, elicited by stereotaxic delivery with Cbs gene using recombinant adeno-associated-virus (rAAV-Cbs), successfully enhanced the sulfide level in the striatum and partially rescued the MPTP-induced dopaminergic neurotoxicity in the midbrain.	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine	211-215	cystathionine beta-synthase	Homo sapiens	67-70
29249255-2	2018	Prior studies identified hydrogen sulfide-generating enzymes cystathionine-beta-synthetase (CBS) and cystathionine-gamma-lyase (CSE) in fetal membranes.	Hydrogen Sulfide	25-41	cystathionine beta-synthase	Homo sapiens	92-95
29249255-8	2018	The effect of l-cysteine was blocked by CBS inhibitor and CBS siRNA but not by CSE inhibitor and CSE siRNA.	Cysteine	14-24	cystathionine beta-synthase	Homo sapiens	40-43
29249255-8	2018	The effect of l-cysteine was blocked by CBS inhibitor and CBS siRNA but not by CSE inhibitor and CSE siRNA.	Cysteine	14-24	cystathionine beta-synthase	Homo sapiens	58-61
30539696-8	2018	RESULTS: HepG2 cells with high CBS expression were less sensitive to DOX and sunitinib and knockdown of CBS significantly elevated the sensitivity to DOX and sunitinib in HepG2 cells.	Sunitinib	77-86	cystathionine beta-synthase	Homo sapiens	31-34
30539696-8	2018	RESULTS: HepG2 cells with high CBS expression were less sensitive to DOX and sunitinib and knockdown of CBS significantly elevated the sensitivity to DOX and sunitinib in HepG2 cells.	Doxorubicin	69-72	cystathionine beta-synthase	Homo sapiens	31-34
30539696-8	2018	RESULTS: HepG2 cells with high CBS expression were less sensitive to DOX and sunitinib and knockdown of CBS significantly elevated the sensitivity to DOX and sunitinib in HepG2 cells.	Doxorubicin	150-153	cystathionine beta-synthase	Homo sapiens	104-107
30539696-8	2018	RESULTS: HepG2 cells with high CBS expression were less sensitive to DOX and sunitinib and knockdown of CBS significantly elevated the sensitivity to DOX and sunitinib in HepG2 cells.	Sunitinib	158-167	cystathionine beta-synthase	Homo sapiens	104-107
30539696-9	2018	In contrast, CBS overexpression increased the resistance of DOX and sunitinib in BEL-7404 cells.	Doxorubicin	60-63	cystathionine beta-synthase	Homo sapiens	13-16
30539696-9	2018	In contrast, CBS overexpression increased the resistance of DOX and sunitinib in BEL-7404 cells.	Sunitinib	68-77	cystathionine beta-synthase	Homo sapiens	13-16
30539696-10	2018	Moreover, the overexpression of CBS caused the up-regulation of the expression level of P-gp and the decrease of DOX accumulation in BEL-7404 cells.	Doxorubicin	113-116	cystathionine beta-synthase	Homo sapiens	32-35
29119254-2	2018	HCU is caused by a deficiency in enzymatic degradation of homocysteine, a toxic intermediate of methionine transformation to cysteine, chiefly due to missense mutations in the cystathionine beta-synthase (CBS) gene.	Methionine	96-106	cystathionine beta-synthase	Homo sapiens	176-203
29119254-5	2018	In this review, we summarize the complex nature of CBS, its multi-domain architecture, the interplay between the three cofactors required for CBS function [heme, pyridoxal-5"-phosphate (PLP), and S-adenosylmethionine (SAM)], as well as the intricate allosteric regulatory mechanism only recently understood, thanks to advances in CBS crystallography.	Heme	156-160	cystathionine beta-synthase	Homo sapiens	142-145
29119254-2	2018	HCU is caused by a deficiency in enzymatic degradation of homocysteine, a toxic intermediate of methionine transformation to cysteine, chiefly due to missense mutations in the cystathionine beta-synthase (CBS) gene.	Methionine	96-106	cystathionine beta-synthase	Homo sapiens	205-208
29119254-5	2018	In this review, we summarize the complex nature of CBS, its multi-domain architecture, the interplay between the three cofactors required for CBS function [heme, pyridoxal-5"-phosphate (PLP), and S-adenosylmethionine (SAM)], as well as the intricate allosteric regulatory mechanism only recently understood, thanks to advances in CBS crystallography.	S-Adenosylmethionine	196-216	cystathionine beta-synthase	Homo sapiens	51-54
29119254-5	2018	In this review, we summarize the complex nature of CBS, its multi-domain architecture, the interplay between the three cofactors required for CBS function [heme, pyridoxal-5"-phosphate (PLP), and S-adenosylmethionine (SAM)], as well as the intricate allosteric regulatory mechanism only recently understood, thanks to advances in CBS crystallography.	S-Adenosylmethionine	218-221	cystathionine beta-synthase	Homo sapiens	51-54
29119254-5	2018	In this review, we summarize the complex nature of CBS, its multi-domain architecture, the interplay between the three cofactors required for CBS function [heme, pyridoxal-5"-phosphate (PLP), and S-adenosylmethionine (SAM)], as well as the intricate allosteric regulatory mechanism only recently understood, thanks to advances in CBS crystallography.	S-Adenosylmethionine	218-221	cystathionine beta-synthase	Homo sapiens	142-145
28859237-9	2018	CONCLUSION: Our findings point to a critical role of CBS in iron homeostasis of the body, and the liver in particular; it is likely that a hemochromatosis-like phenotype in patients can be induced by aberration not only in the expression of key molecules in the hepcidin pathway but also of those related to CBS.	Iron	60-64	cystathionine beta-synthase	Homo sapiens	53-56
29119254-5	2018	In this review, we summarize the complex nature of CBS, its multi-domain architecture, the interplay between the three cofactors required for CBS function [heme, pyridoxal-5"-phosphate (PLP), and S-adenosylmethionine (SAM)], as well as the intricate allosteric regulatory mechanism only recently understood, thanks to advances in CBS crystallography.	S-Adenosylmethionine	218-221	cystathionine beta-synthase	Homo sapiens	142-145
29119254-2	2018	HCU is caused by a deficiency in enzymatic degradation of homocysteine, a toxic intermediate of methionine transformation to cysteine, chiefly due to missense mutations in the cystathionine beta-synthase (CBS) gene.	Cysteine	62-70	cystathionine beta-synthase	Homo sapiens	176-203
29119254-2	2018	HCU is caused by a deficiency in enzymatic degradation of homocysteine, a toxic intermediate of methionine transformation to cysteine, chiefly due to missense mutations in the cystathionine beta-synthase (CBS) gene.	Cysteine	62-70	cystathionine beta-synthase	Homo sapiens	205-208
29119254-5	2018	In this review, we summarize the complex nature of CBS, its multi-domain architecture, the interplay between the three cofactors required for CBS function [heme, pyridoxal-5"-phosphate (PLP), and S-adenosylmethionine (SAM)], as well as the intricate allosteric regulatory mechanism only recently understood, thanks to advances in CBS crystallography.	Heme	156-160	cystathionine beta-synthase	Homo sapiens	51-54
29119254-5	2018	In this review, we summarize the complex nature of CBS, its multi-domain architecture, the interplay between the three cofactors required for CBS function [heme, pyridoxal-5"-phosphate (PLP), and S-adenosylmethionine (SAM)], as well as the intricate allosteric regulatory mechanism only recently understood, thanks to advances in CBS crystallography.	Heme	156-160	cystathionine beta-synthase	Homo sapiens	142-145
29259741-1	2017	Hydrogen sulfide is produced from l-cysteine by the action of both cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS) and increasingly has been found to play a profound regulatory role in a range of physiological processes.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	103-130
30393252-2	2018	H2S is produced from l-cysteine by pyridoxal 5"-phosphate (PLP)-dependent enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	83-110
30393252-2	2018	H2S is produced from l-cysteine by pyridoxal 5"-phosphate (PLP)-dependent enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Cysteine	21-31	cystathionine beta-synthase	Homo sapiens	83-110
30393252-2	2018	H2S is produced from l-cysteine by pyridoxal 5"-phosphate (PLP)-dependent enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Pyridoxal Phosphate	59-62	cystathionine beta-synthase	Homo sapiens	83-110
28724639-2	2017	Recently recognised as potent antioxidants, reactive persulfide and polysulfide species are biosynthesised by cystathionine beta-synthase and cystathionine gamma-lyase.	reactive persulfide	44-63	cystathionine beta-synthase	Homo sapiens	110-137
28724639-2	2017	Recently recognised as potent antioxidants, reactive persulfide and polysulfide species are biosynthesised by cystathionine beta-synthase and cystathionine gamma-lyase.	polysulfide	68-79	cystathionine beta-synthase	Homo sapiens	110-137
29054837-10	2017	We found that genes coding for key enzymes in de novo glutathione synthesis are highly expressed in IDH-mutant gliomas and the expression of cystathionine-beta-synthase (CBS) correlates with patient survival in the oligodendroglial subtype.	Glutathione	54-65	cystathionine beta-synthase	Homo sapiens	141-168
30108905-0	2018	Antitumor effect of sikokianin C, a selective cystathionine beta-synthase inhibitor, against human colon cancer in vitro and in vivo.	Sikokianin C	20-32	cystathionine beta-synthase	Homo sapiens	46-73
30108905-3	2018	In our previous study, a natural biflavonoid compound, sikokianin C, was identified as a potent and selective inhibitor of CBS.	Biflavonoids	33-44	cystathionine beta-synthase	Homo sapiens	123-126
29259741-1	2017	Hydrogen sulfide is produced from l-cysteine by the action of both cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS) and increasingly has been found to play a profound regulatory role in a range of physiological processes.	Cysteine	34-44	cystathionine beta-synthase	Homo sapiens	103-130
28398086-4	2017	Importantly, endogenous polysulfide and persulfide formation has been reported to occur via transsulfuration enzymes, cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS).	polysulfide	24-35	cystathionine beta-synthase	Homo sapiens	154-181
28258516-1	2017	Homocystinuria is an inborn error of amino acid metabolism caused by deficiency of cystathionine ss-synthase (CBS) activity, biochemically characterized by homocysteine (Hcy) and methionine (Met) accumulation in biological fluids and high urinary excretion of homocystine.	Homocysteine	156-168	cystathionine beta-synthase	Homo sapiens	110-113
28258516-1	2017	Homocystinuria is an inborn error of amino acid metabolism caused by deficiency of cystathionine ss-synthase (CBS) activity, biochemically characterized by homocysteine (Hcy) and methionine (Met) accumulation in biological fluids and high urinary excretion of homocystine.	Homocystine	260-271	cystathionine beta-synthase	Homo sapiens	110-113
28923859-1	2017	The trans-sulfuration enzyme cystathionine-beta-synthase (CBS) and its product hydrogen sulfide (H2S) are aberrantly upregulated in colorectal cancers, where they contribute to tumor growth and progression by both autocrine and paracrine mechanisms.	Hydrogen Sulfide	79-95	cystathionine beta-synthase	Homo sapiens	29-56
28923859-1	2017	The trans-sulfuration enzyme cystathionine-beta-synthase (CBS) and its product hydrogen sulfide (H2S) are aberrantly upregulated in colorectal cancers, where they contribute to tumor growth and progression by both autocrine and paracrine mechanisms.	Hydrogen Sulfide	79-95	cystathionine beta-synthase	Homo sapiens	58-61
28923859-1	2017	The trans-sulfuration enzyme cystathionine-beta-synthase (CBS) and its product hydrogen sulfide (H2S) are aberrantly upregulated in colorectal cancers, where they contribute to tumor growth and progression by both autocrine and paracrine mechanisms.	Hydrogen Sulfide	97-100	cystathionine beta-synthase	Homo sapiens	29-56
28923859-1	2017	The trans-sulfuration enzyme cystathionine-beta-synthase (CBS) and its product hydrogen sulfide (H2S) are aberrantly upregulated in colorectal cancers, where they contribute to tumor growth and progression by both autocrine and paracrine mechanisms.	Hydrogen Sulfide	97-100	cystathionine beta-synthase	Homo sapiens	58-61
28923859-9	2017	Taken together, these results establish that activation of the CBS/H2S axis promotes colon carcinogenesis.	Hydrogen Sulfide	67-70	cystathionine beta-synthase	Homo sapiens	63-66
28876927-0	2017	Attenuation of Antioxidant Capacity in Human Breast Cancer Cells by Carbon Monoxide through Inhibition of Cystathionine beta-Synthase Activity: Implications in Chemotherapeutic Drug Sensitivity.	Carbon Monoxide	68-83	cystathionine beta-synthase	Homo sapiens	106-133
28876927-4	2017	Here, we have identified a mechanism, unique to breast cancer cells, whereby cystathionine beta-synthase (CBS) promotes elevated GSH/GSSG.	Glutathione	129-132	cystathionine beta-synthase	Homo sapiens	77-104
28876927-4	2017	Here, we have identified a mechanism, unique to breast cancer cells, whereby cystathionine beta-synthase (CBS) promotes elevated GSH/GSSG.	Glutathione	129-132	cystathionine beta-synthase	Homo sapiens	106-109
28876927-4	2017	Here, we have identified a mechanism, unique to breast cancer cells, whereby cystathionine beta-synthase (CBS) promotes elevated GSH/GSSG.	Glutathione Disulfide	133-137	cystathionine beta-synthase	Homo sapiens	77-104
28876927-4	2017	Here, we have identified a mechanism, unique to breast cancer cells, whereby cystathionine beta-synthase (CBS) promotes elevated GSH/GSSG.	Glutathione Disulfide	133-137	cystathionine beta-synthase	Homo sapiens	106-109
28876927-5	2017	Lentiviral silencing of CBS in human breast cancer cells attenuated GSH/GSSG, total GSH, nuclear factor erythroid 2-related factor 2 (Nrf2), and processes downstream of Nrf2 that promote GSH synthesis and regeneration of GSH from GSSG.	Glutathione	68-71	cystathionine beta-synthase	Homo sapiens	24-27
28876927-5	2017	Lentiviral silencing of CBS in human breast cancer cells attenuated GSH/GSSG, total GSH, nuclear factor erythroid 2-related factor 2 (Nrf2), and processes downstream of Nrf2 that promote GSH synthesis and regeneration of GSH from GSSG.	Glutathione Disulfide	72-76	cystathionine beta-synthase	Homo sapiens	24-27
28876927-5	2017	Lentiviral silencing of CBS in human breast cancer cells attenuated GSH/GSSG, total GSH, nuclear factor erythroid 2-related factor 2 (Nrf2), and processes downstream of Nrf2 that promote GSH synthesis and regeneration of GSH from GSSG.	Glutathione	84-87	cystathionine beta-synthase	Homo sapiens	24-27
28876927-5	2017	Lentiviral silencing of CBS in human breast cancer cells attenuated GSH/GSSG, total GSH, nuclear factor erythroid 2-related factor 2 (Nrf2), and processes downstream of Nrf2 that promote GSH synthesis and regeneration of GSH from GSSG.	Glutathione	84-87	cystathionine beta-synthase	Homo sapiens	24-27
28876927-5	2017	Lentiviral silencing of CBS in human breast cancer cells attenuated GSH/GSSG, total GSH, nuclear factor erythroid 2-related factor 2 (Nrf2), and processes downstream of Nrf2 that promote GSH synthesis and regeneration of GSH from GSSG.	Glutathione	84-87	cystathionine beta-synthase	Homo sapiens	24-27
28876927-5	2017	Lentiviral silencing of CBS in human breast cancer cells attenuated GSH/GSSG, total GSH, nuclear factor erythroid 2-related factor 2 (Nrf2), and processes downstream of Nrf2 that promote GSH synthesis and regeneration of GSH from GSSG.	Glutathione Disulfide	230-234	cystathionine beta-synthase	Homo sapiens	24-27
28876927-6	2017	Carbon monoxide (CO) reduced GSH/GSSG in three breast cancer cell lines by inhibiting CBS.	Carbon Monoxide	0-15	cystathionine beta-synthase	Homo sapiens	86-89
28876927-6	2017	Carbon monoxide (CO) reduced GSH/GSSG in three breast cancer cell lines by inhibiting CBS.	Carbon Monoxide	17-19	cystathionine beta-synthase	Homo sapiens	86-89
28876927-6	2017	Carbon monoxide (CO) reduced GSH/GSSG in three breast cancer cell lines by inhibiting CBS.	Glutathione	29-32	cystathionine beta-synthase	Homo sapiens	86-89
28481637-4	2017	The generation of H2S is catalyzed by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST).	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	38-65
28481637-4	2017	The generation of H2S is catalyzed by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST).	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	67-70
29037129-1	2017	Cystathionine beta-synthase (CBS) domains discovered 20 years ago can bind different adenosine derivatives (AMP, ADP, ATP, S-adenosylmethionine, NAD, diadenosine polyphosphates) and thus regulate the activities of numerous proteins.	S-Adenosylmethionine	123-143	cystathionine beta-synthase	Homo sapiens	0-27
29037129-1	2017	Cystathionine beta-synthase (CBS) domains discovered 20 years ago can bind different adenosine derivatives (AMP, ADP, ATP, S-adenosylmethionine, NAD, diadenosine polyphosphates) and thus regulate the activities of numerous proteins.	NAD	145-148	cystathionine beta-synthase	Homo sapiens	0-27
28398086-4	2017	Importantly, endogenous polysulfide and persulfide formation has been reported to occur via transsulfuration enzymes, cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS).	persulfides	40-50	cystathionine beta-synthase	Homo sapiens	154-181
29037129-1	2017	Cystathionine beta-synthase (CBS) domains discovered 20 years ago can bind different adenosine derivatives (AMP, ADP, ATP, S-adenosylmethionine, NAD, diadenosine polyphosphates) and thus regulate the activities of numerous proteins.	diadenosine polyphosphates	150-176	cystathionine beta-synthase	Homo sapiens	0-27
29037129-1	2017	Cystathionine beta-synthase (CBS) domains discovered 20 years ago can bind different adenosine derivatives (AMP, ADP, ATP, S-adenosylmethionine, NAD, diadenosine polyphosphates) and thus regulate the activities of numerous proteins.	Adenosine	85-94	cystathionine beta-synthase	Homo sapiens	0-27
29037129-1	2017	Cystathionine beta-synthase (CBS) domains discovered 20 years ago can bind different adenosine derivatives (AMP, ADP, ATP, S-adenosylmethionine, NAD, diadenosine polyphosphates) and thus regulate the activities of numerous proteins.	Adenosine Monophosphate	108-111	cystathionine beta-synthase	Homo sapiens	0-27
29037129-1	2017	Cystathionine beta-synthase (CBS) domains discovered 20 years ago can bind different adenosine derivatives (AMP, ADP, ATP, S-adenosylmethionine, NAD, diadenosine polyphosphates) and thus regulate the activities of numerous proteins.	Adenosine Diphosphate	113-116	cystathionine beta-synthase	Homo sapiens	0-27
29037129-1	2017	Cystathionine beta-synthase (CBS) domains discovered 20 years ago can bind different adenosine derivatives (AMP, ADP, ATP, S-adenosylmethionine, NAD, diadenosine polyphosphates) and thus regulate the activities of numerous proteins.	Adenosine Triphosphate	118-121	cystathionine beta-synthase	Homo sapiens	0-27
28978633-9	2017	For pharmacological inhibition of H2S synthesis, there are now several small molecule compounds targeting each of the three H2S-producing enzymes cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase, and 3-mercaptopyruvate sulfurtransferase.	Hydrogen Sulfide	34-37	cystathionine beta-synthase	Homo sapiens	146-173
28760490-5	2017	Cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE), the enzymes mainly responsible for H2S biosynthesis, are constitutively expressed in HCC.	Hydrogen Sulfide	106-109	cystathionine beta-synthase	Homo sapiens	0-27
28978633-9	2017	For pharmacological inhibition of H2S synthesis, there are now several small molecule compounds targeting each of the three H2S-producing enzymes cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase, and 3-mercaptopyruvate sulfurtransferase.	Hydrogen Sulfide	34-37	cystathionine beta-synthase	Homo sapiens	175-178
28978633-9	2017	For pharmacological inhibition of H2S synthesis, there are now several small molecule compounds targeting each of the three H2S-producing enzymes cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase, and 3-mercaptopyruvate sulfurtransferase.	Hydrogen Sulfide	124-127	cystathionine beta-synthase	Homo sapiens	146-173
28978633-9	2017	For pharmacological inhibition of H2S synthesis, there are now several small molecule compounds targeting each of the three H2S-producing enzymes cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase, and 3-mercaptopyruvate sulfurtransferase.	Hydrogen Sulfide	124-127	cystathionine beta-synthase	Homo sapiens	175-178
28978633-11	2017	Moreover, some of these compounds (e.g., cell-permeable prodrugs of the CBS inhibitor aminooxyacetate, or benserazide, a potentially repurposable CBS inhibitor) may serve as starting points for future clinical translation.	Aminooxyacetic Acid	86-101	cystathionine beta-synthase	Homo sapiens	72-75
28978633-11	2017	Moreover, some of these compounds (e.g., cell-permeable prodrugs of the CBS inhibitor aminooxyacetate, or benserazide, a potentially repurposable CBS inhibitor) may serve as starting points for future clinical translation.	Benserazide	106-117	cystathionine beta-synthase	Homo sapiens	146-149
28930162-1	2017	Protein-depleted states generate allosteric inhibition of liver cystathionine beta-synthase (CBS), which governs the first enzymatic step of the transsulfuration cascade, resulting in upstream accretion of homocysteine (Hcy) in body fluids.	Homocysteine	220-223	cystathionine beta-synthase	Homo sapiens	64-91
29024947-1	2017	Endogenous hydrogen sulfide (H2S), mainly synthesized by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CTH), has been implicated in regulating placental angiogenesis; however, the underlying mechanisms are unknown.	Hydrogen Sulfide	11-27	cystathionine beta-synthase	Homo sapiens	57-84
29024947-1	2017	Endogenous hydrogen sulfide (H2S), mainly synthesized by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CTH), has been implicated in regulating placental angiogenesis; however, the underlying mechanisms are unknown.	Hydrogen Sulfide	11-27	cystathionine beta-synthase	Homo sapiens	86-89
29024947-7	2017	Primary human villous trophoblasts (HVT) were more potent than trophoblast cell lines in stimulating oFPAEC migration that was inhibited by CHH and CHH/BCA combination in accordance with its H2S synthesizing activity linked to CBS and CTH expression patterns.	bromochloroacetic acid	152-155	cystathionine beta-synthase	Homo sapiens	227-230
29024947-1	2017	Endogenous hydrogen sulfide (H2S), mainly synthesized by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CTH), has been implicated in regulating placental angiogenesis; however, the underlying mechanisms are unknown.	Hydrogen Sulfide	29-32	cystathionine beta-synthase	Homo sapiens	57-84
29024947-1	2017	Endogenous hydrogen sulfide (H2S), mainly synthesized by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CTH), has been implicated in regulating placental angiogenesis; however, the underlying mechanisms are unknown.	Hydrogen Sulfide	29-32	cystathionine beta-synthase	Homo sapiens	86-89
29024947-4	2017	The H2S producing ability of BeWo cells was significantly inhibited by either inhibitors of CBS (carboxymethyl hydroxylamine hemihydrochloride, CHH) or CTH (beta-cyano-L-alanine, BCA) and that in HTR-8/SVneo cells was inhibited by CHH only.	Hydrogen Sulfide	4-7	cystathionine beta-synthase	Homo sapiens	92-95
29024947-4	2017	The H2S producing ability of BeWo cells was significantly inhibited by either inhibitors of CBS (carboxymethyl hydroxylamine hemihydrochloride, CHH) or CTH (beta-cyano-L-alanine, BCA) and that in HTR-8/SVneo cells was inhibited by CHH only.	carboxymethyl hydroxylamine hemihydrochloride	97-142	cystathionine beta-synthase	Homo sapiens	92-95
28656241-4	2017	The results indicated that the levels of H2S derived from the brain decreased over time following ECM infection, and that the low H2S bioavailability was partially caused by decreased expression of the H2S generating enzyme, cystathionine-beta-synthase.	Hydrogen Sulfide	130-133	cystathionine beta-synthase	Homo sapiens	225-252
28900398-5	2017	In the retina, H2S is generated in the presence of cystathionine-beta-synthase, cystathionine-gamma-lyase, and 3-mercaptopyruvate sulfurtransferase from L-cysteine.	Hydrogen Sulfide	15-18	cystathionine beta-synthase	Homo sapiens	51-78
28900398-5	2017	In the retina, H2S is generated in the presence of cystathionine-beta-synthase, cystathionine-gamma-lyase, and 3-mercaptopyruvate sulfurtransferase from L-cysteine.	Cysteine	153-163	cystathionine beta-synthase	Homo sapiens	51-78
28550180-10	2017	Our study suggests the K475E mutation induces alteration in basal AMPK activity and results in a hypertrophy phenotype involving the mechanistic target of rapamycin signaling pathway, which can be reversed with rapamycin.NEW &amp; NOTEWORTHY We identified a novel, de novo PRKAG2 mutation (K475E) in the cystathionine beta-synthase 3 repeat, a region critical for AMP binding but with no previous reported mutation.	Sirolimus	155-164	cystathionine beta-synthase	Homo sapiens	304-331
28550180-10	2017	Our study suggests the K475E mutation induces alteration in basal AMPK activity and results in a hypertrophy phenotype involving the mechanistic target of rapamycin signaling pathway, which can be reversed with rapamycin.NEW &amp; NOTEWORTHY We identified a novel, de novo PRKAG2 mutation (K475E) in the cystathionine beta-synthase 3 repeat, a region critical for AMP binding but with no previous reported mutation.	Adenosine Monophosphate	226-229	cystathionine beta-synthase	Homo sapiens	304-331
28550180-10	2017	Our study suggests the K475E mutation induces alteration in basal AMPK activity and results in a hypertrophy phenotype involving the mechanistic target of rapamycin signaling pathway, which can be reversed with rapamycin.NEW &amp; NOTEWORTHY We identified a novel, de novo PRKAG2 mutation (K475E) in the cystathionine beta-synthase 3 repeat, a region critical for AMP binding but with no previous reported mutation.	Adenosine Monophosphate	66-69	cystathionine beta-synthase	Homo sapiens	304-331
28810796-0	2017	Molecular dynamics simulations of fluid cyclopropane with MP2/CBS-fitted intermolecular interaction potentials.	cyclopropane	40-52	cystathionine beta-synthase	Homo sapiens	62-65
28656194-9	2017	In addition, we found that treatment with NaHS (a H2S donor) or S-adenosyl-L-methionine (SAM, a CBS agonist) mitigated OGD-induced ER stress, as well as the NO level, nNOS activity and AMPK phosphorylation in PC12 cells.	sodium bisulfide	42-46	cystathionine beta-synthase	Homo sapiens	96-99
28656194-9	2017	In addition, we found that treatment with NaHS (a H2S donor) or S-adenosyl-L-methionine (SAM, a CBS agonist) mitigated OGD-induced ER stress, as well as the NO level, nNOS activity and AMPK phosphorylation in PC12 cells.	S-Adenosylmethionine	64-87	cystathionine beta-synthase	Homo sapiens	96-99
28656194-9	2017	In addition, we found that treatment with NaHS (a H2S donor) or S-adenosyl-L-methionine (SAM, a CBS agonist) mitigated OGD-induced ER stress, as well as the NO level, nNOS activity and AMPK phosphorylation in PC12 cells.	S-Adenosylmethionine	89-92	cystathionine beta-synthase	Homo sapiens	96-99
28656241-4	2017	The results indicated that the levels of H2S derived from the brain decreased over time following ECM infection, and that the low H2S bioavailability was partially caused by decreased expression of the H2S generating enzyme, cystathionine-beta-synthase.	Hydrogen Sulfide	130-133	cystathionine beta-synthase	Homo sapiens	225-252
28398541-7	2017	VEGF stimulated CBS protein expression, accounting for VEGF-stimulated H2S production in hUAECs.	Hydrogen Sulfide	71-74	cystathionine beta-synthase	Homo sapiens	16-19
28552745-0	2017	A critical role for cystathionine-beta-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery.	Hydrogen Sulfide	51-67	cystathionine beta-synthase	Homo sapiens	20-47
28383821-12	2017	Aminooxyacetic acid (AOAA), a cystathionine beta-synthase inhibitor, exerted inhibitory effects on fundus smooth muscle tension; these effects were also suppressed by l-NAME.	Aminooxyacetic Acid	0-19	cystathionine beta-synthase	Homo sapiens	30-57
28383821-12	2017	Aminooxyacetic acid (AOAA), a cystathionine beta-synthase inhibitor, exerted inhibitory effects on fundus smooth muscle tension; these effects were also suppressed by l-NAME.	Aminooxyacetic Acid	21-25	cystathionine beta-synthase	Homo sapiens	30-57
28383821-12	2017	Aminooxyacetic acid (AOAA), a cystathionine beta-synthase inhibitor, exerted inhibitory effects on fundus smooth muscle tension; these effects were also suppressed by l-NAME.	NG-Nitroarginine Methyl Ester	167-173	cystathionine beta-synthase	Homo sapiens	30-57
28383821-17	2017	Cystathionine beta-synthase siRNA interference significantly increased eNOS phosphorylation at serine 1177 and Akt phosphorylation at serine 308 and threonine 473.	Serine	95-101	cystathionine beta-synthase	Homo sapiens	0-27
28383821-17	2017	Cystathionine beta-synthase siRNA interference significantly increased eNOS phosphorylation at serine 1177 and Akt phosphorylation at serine 308 and threonine 473.	Serine	134-140	cystathionine beta-synthase	Homo sapiens	0-27
28383821-17	2017	Cystathionine beta-synthase siRNA interference significantly increased eNOS phosphorylation at serine 1177 and Akt phosphorylation at serine 308 and threonine 473.	Threonine	149-158	cystathionine beta-synthase	Homo sapiens	0-27
28488385-2	2017	The c.797 G&gt;A (p.R266K) mutation in CBS was originally described in several Norwegian pyridoxine responsive CBS deficient patients, and heterologous gene expression studies have shown that the protein has near wild-type levels of enzyme activity.	Pyridoxine	89-99	cystathionine beta-synthase	Homo sapiens	39-42
28552745-6	2017	The CBS inhibitor amino-oxyacetate (AOAA) reduced both phases of the hypoxic response.	Aminooxyacetic Acid	18-34	cystathionine beta-synthase	Homo sapiens	4-7
28552745-6	2017	The CBS inhibitor amino-oxyacetate (AOAA) reduced both phases of the hypoxic response.	Aminooxyacetic Acid	36-40	cystathionine beta-synthase	Homo sapiens	4-7
28552745-10	2017	H2S production in coronary arteries was blocked by CBS inhibition (AOAA), but not by CSE inhibition (PPG).	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	51-54
28552745-12	2017	Of the three H2S-producing enzymes, CBS, expressed in the vascular smooth muscle, appears to be the most important for H2S generated during hypoxic relaxation of the coronary artery.	Hydrogen Sulfide	13-16	cystathionine beta-synthase	Homo sapiens	36-39
28552745-12	2017	Of the three H2S-producing enzymes, CBS, expressed in the vascular smooth muscle, appears to be the most important for H2S generated during hypoxic relaxation of the coronary artery.	Hydrogen Sulfide	119-122	cystathionine beta-synthase	Homo sapiens	36-39
28552745-13	2017	A contribution from other H2S-producing enzymes only becomes apparent when CBS activity is inhibited.	Hydrogen Sulfide	26-29	cystathionine beta-synthase	Homo sapiens	75-78
28804545-2	2017	Recently, hydrogen sulfide (H2S), a gaseous transmitter endogenously generated by cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST), is found to improve mitochondrial function.	Hydrogen Sulfide	10-26	cystathionine beta-synthase	Homo sapiens	82-109
28804545-2	2017	Recently, hydrogen sulfide (H2S), a gaseous transmitter endogenously generated by cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST), is found to improve mitochondrial function.	Hydrogen Sulfide	10-26	cystathionine beta-synthase	Homo sapiens	111-114
28804545-2	2017	Recently, hydrogen sulfide (H2S), a gaseous transmitter endogenously generated by cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST), is found to improve mitochondrial function.	Hydrogen Sulfide	28-31	cystathionine beta-synthase	Homo sapiens	82-109
28804545-2	2017	Recently, hydrogen sulfide (H2S), a gaseous transmitter endogenously generated by cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST), is found to improve mitochondrial function.	Hydrogen Sulfide	28-31	cystathionine beta-synthase	Homo sapiens	111-114
28668830-3	2017	Nampt concomitantly regulates hydrogen sulfide (H2S)-synthesizing enzyme levels, including cystathionine-beta-synthase (CBS).	Hydrogen Sulfide	30-46	cystathionine beta-synthase	Homo sapiens	91-118
28668830-3	2017	Nampt concomitantly regulates hydrogen sulfide (H2S)-synthesizing enzyme levels, including cystathionine-beta-synthase (CBS).	Hydrogen Sulfide	30-46	cystathionine beta-synthase	Homo sapiens	120-123
28668830-3	2017	Nampt concomitantly regulates hydrogen sulfide (H2S)-synthesizing enzyme levels, including cystathionine-beta-synthase (CBS).	Hydrogen Sulfide	48-51	cystathionine beta-synthase	Homo sapiens	91-118
28668830-3	2017	Nampt concomitantly regulates hydrogen sulfide (H2S)-synthesizing enzyme levels, including cystathionine-beta-synthase (CBS).	Hydrogen Sulfide	48-51	cystathionine beta-synthase	Homo sapiens	120-123
28668830-4	2017	MATERIALS AND METHODS: We used tissue microarrays to examine Nampt and the H2S-synthesizing enzyme CBS protein levels in benign kidney, RCC, UC and ROs.	Hydrogen Sulfide	75-78	cystathionine beta-synthase	Homo sapiens	99-102
28108276-6	2017	Western blotting analysis shows that oxidative stress enhanced RAGE protein expression which was attenuated by either NaHS or over-expression of cystathionine beta-synthase (CBS), a critical enzyme for producing H2S in brain cells.	Hydrogen Sulfide	212-215	cystathionine beta-synthase	Homo sapiens	145-172
28431470-1	2017	Homocystinuria due to loss of cystathionine beta-synthase (CBS) causes accumulation of homocysteine and depletion of cysteine.	Homocysteine	87-99	cystathionine beta-synthase	Homo sapiens	59-62
28431470-1	2017	Homocystinuria due to loss of cystathionine beta-synthase (CBS) causes accumulation of homocysteine and depletion of cysteine.	Cysteine	91-99	cystathionine beta-synthase	Homo sapiens	30-57
28431470-1	2017	Homocystinuria due to loss of cystathionine beta-synthase (CBS) causes accumulation of homocysteine and depletion of cysteine.	Cysteine	91-99	cystathionine beta-synthase	Homo sapiens	59-62
28431470-3	2017	Attenuation of potency was observed, which necessitated a screen of several PEG-CBS conjugates for their efficacy to correct and maintain the plasma metabolite profile of murine homocystinuria after repeated administrations interrupted with washouts.	Polyethylene Glycols	76-79	cystathionine beta-synthase	Homo sapiens	80-83
28431470-4	2017	We found that CBS coupling with maleimide PEG inconsistently modified the enzyme.	maleimide	32-41	cystathionine beta-synthase	Homo sapiens	14-17
28431470-4	2017	We found that CBS coupling with maleimide PEG inconsistently modified the enzyme.	Polyethylene Glycols	42-45	cystathionine beta-synthase	Homo sapiens	14-17
28431470-5	2017	In contrast, the PEG-CBS conjugate with 20 kDa N-hydroxysuccinimide-PEG showed very little loss of potency likely due to a reproducible PEGylation resulting in species modified with five PEGs per subunit on average.	n-hydroxysuccinimide-peg	47-71	cystathionine beta-synthase	Homo sapiens	17-24
28431470-5	2017	In contrast, the PEG-CBS conjugate with 20 kDa N-hydroxysuccinimide-PEG showed very little loss of potency likely due to a reproducible PEGylation resulting in species modified with five PEGs per subunit on average.	pegs	187-191	cystathionine beta-synthase	Homo sapiens	17-24
28431470-6	2017	We developed assays suitable for monitoring the extent of CBS PEGylation and demonstrated a sustainable partial normalization of homocystinuria upon continuous PEG-CBS administration via osmotic pumps.	Polyethylene Glycols	62-65	cystathionine beta-synthase	Homo sapiens	58-61
28881655-5	2017	Then, the correlation analysis between folate level, DNA methylation alteration in promoter and expression of CBS was carried out in vitro and vivo.	Folic Acid	39-45	cystathionine beta-synthase	Homo sapiens	110-113
28188925-1	2017	This work aimed at studying a possible influence of methylenetetrahydrofolate reductase (MTHFR; c. 677C&gt;T) and cystathionine beta-synthase (CBS; 844ins68) polymorphisms on overall oxidative status of sickle cell anemia (SCA) patients and on routine markers, correlating them with hydroxycarbamide (HC) treatment.	Hydroxyurea	283-299	cystathionine beta-synthase	Homo sapiens	143-146
28440458-11	2017	Collectively, our results demonstrated that the CBS/H2S system plays important roles in human hepatoma cells and QIC2 significantly inhibited cell growth via downregulation of the system.	Hydrogen Sulfide	52-55	cystathionine beta-synthase	Homo sapiens	48-51
28397458-6	2017	Of the total, the expression of cystathionine-beta-synthase (CBS) involved in methyl metabolism and its important substrate, homocysteine, were all detected by realtime RT-PCR and immunostaining.	Homocysteine	125-137	cystathionine beta-synthase	Homo sapiens	32-59
28397458-6	2017	Of the total, the expression of cystathionine-beta-synthase (CBS) involved in methyl metabolism and its important substrate, homocysteine, were all detected by realtime RT-PCR and immunostaining.	Homocysteine	125-137	cystathionine beta-synthase	Homo sapiens	61-64
28397458-9	2017	Among the total, a hypermethylation patterns existed in the promoter of CBS in CRC (p &lt; 0.001), and the hypermethylation is related with the down-regulation of CBS and the accumulation of homocysteine in vitro and vivo (p &lt; 0.001).	Homocysteine	191-203	cystathionine beta-synthase	Homo sapiens	72-75
28454695-7	2017	Transfection of syncytiotrophoblasts with CBS siRNA and CSE siRNA reversed the above effects of l-cysteine.	Cysteine	96-106	cystathionine beta-synthase	Homo sapiens	42-45
28339573-0	2017	Augmented H2S production via cystathionine-beta-synthase upregulation plays a role in pregnancy-associated uterine vasodilation.	Hydrogen Sulfide	10-13	cystathionine beta-synthase	Homo sapiens	29-56
28339573-1	2017	Endogenous hydrogen sulfide (H2S) synthesized via metabolizing L-cysteine by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) is a potent vasodilator and angiogenic factor.	Hydrogen Sulfide	11-27	cystathionine beta-synthase	Homo sapiens	77-104
28339573-1	2017	Endogenous hydrogen sulfide (H2S) synthesized via metabolizing L-cysteine by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) is a potent vasodilator and angiogenic factor.	Hydrogen Sulfide	11-27	cystathionine beta-synthase	Homo sapiens	106-109
28339573-1	2017	Endogenous hydrogen sulfide (H2S) synthesized via metabolizing L-cysteine by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) is a potent vasodilator and angiogenic factor.	Hydrogen Sulfide	29-32	cystathionine beta-synthase	Homo sapiens	77-104
28339573-1	2017	Endogenous hydrogen sulfide (H2S) synthesized via metabolizing L-cysteine by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) is a potent vasodilator and angiogenic factor.	Hydrogen Sulfide	29-32	cystathionine beta-synthase	Homo sapiens	106-109
28339573-1	2017	Endogenous hydrogen sulfide (H2S) synthesized via metabolizing L-cysteine by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) is a potent vasodilator and angiogenic factor.	Cysteine	63-73	cystathionine beta-synthase	Homo sapiens	77-104
28339573-1	2017	Endogenous hydrogen sulfide (H2S) synthesized via metabolizing L-cysteine by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) is a potent vasodilator and angiogenic factor.	Cysteine	63-73	cystathionine beta-synthase	Homo sapiens	106-109
28339573-2	2017	The objectives of this study were to determine if human uterine artery (UA) H2S production increases with augmented expression and/or activity of CBS and/or CSE during the menstrual cycle and pregnancy and whether exogenous H2S dilates UA.	Hydrogen Sulfide	76-79	cystathionine beta-synthase	Homo sapiens	146-149
28339573-7	2017	H2S production was greater in NP pPRM and P than NP sPRM UAs and inhibited by the specific CBS but not CSE inhibitor.	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	91-94
28339573-12	2017	Thus, human UA H2S production is augmented with endothelium and smooth muscle CBS upregulation, contributing to UA vasodilation in the estrogen-dominant physiological states in the proliferative phase of the menstrual cycle and pregnancy.	Hydrogen Sulfide	15-18	cystathionine beta-synthase	Homo sapiens	78-81
28049024-9	2017	While simultaneous treatment with reactive persulfide and polysulfide, Na2S2 and Na2S4, blocked 1,4-NQ-dependent protein modification and HSF1 activation in A431 cells, the knockdown of Cys persulfide producing enzymes cystathionine beta-synthase (CBS) and/or cystathionine gamma-lyase (CSE) enhanced these phenomena.	persulfides	43-53	cystathionine beta-synthase	Homo sapiens	219-246
28049024-9	2017	While simultaneous treatment with reactive persulfide and polysulfide, Na2S2 and Na2S4, blocked 1,4-NQ-dependent protein modification and HSF1 activation in A431 cells, the knockdown of Cys persulfide producing enzymes cystathionine beta-synthase (CBS) and/or cystathionine gamma-lyase (CSE) enhanced these phenomena.	polysulfide	58-69	cystathionine beta-synthase	Homo sapiens	219-246
28049024-9	2017	While simultaneous treatment with reactive persulfide and polysulfide, Na2S2 and Na2S4, blocked 1,4-NQ-dependent protein modification and HSF1 activation in A431 cells, the knockdown of Cys persulfide producing enzymes cystathionine beta-synthase (CBS) and/or cystathionine gamma-lyase (CSE) enhanced these phenomena.	Sodium disulfide	71-76	cystathionine beta-synthase	Homo sapiens	219-246
28049024-9	2017	While simultaneous treatment with reactive persulfide and polysulfide, Na2S2 and Na2S4, blocked 1,4-NQ-dependent protein modification and HSF1 activation in A431 cells, the knockdown of Cys persulfide producing enzymes cystathionine beta-synthase (CBS) and/or cystathionine gamma-lyase (CSE) enhanced these phenomena.	Sodium tetrasulfide	81-86	cystathionine beta-synthase	Homo sapiens	219-246
28744364-3	2017	H2S is mainly produced by three enzymes, including cystathionine beta-synthase, cystathionine gamma-lyase and 3-mercaptopyruvate sulfurtransferase along with cysteine aminotransferase.	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	51-78
28431470-1	2017	Homocystinuria due to loss of cystathionine beta-synthase (CBS) causes accumulation of homocysteine and depletion of cysteine.	Homocysteine	87-99	cystathionine beta-synthase	Homo sapiens	30-57
28394038-12	2017	The activities of CBS, CSE, and levels of H2 S were restored in HHcy animals administered H2 S. Exogenous H2 S also ameliorated behavioral deficits accompanied by significant increase in catecholamines.	Hydrogen	90-92	cystathionine beta-synthase	Homo sapiens	18-21
28440458-2	2017	As endogenous H2S exerts pro-cancer functions, inhibition of its production in cancer cells may provide a new cancer treatment strategy and be achieved via regulation of the function of cystathionine beta-synthase (CBS), one of the main metabolic enzymes synthesizing H2S.	Hydrogen Sulfide	14-17	cystathionine beta-synthase	Homo sapiens	186-213
28440458-2	2017	As endogenous H2S exerts pro-cancer functions, inhibition of its production in cancer cells may provide a new cancer treatment strategy and be achieved via regulation of the function of cystathionine beta-synthase (CBS), one of the main metabolic enzymes synthesizing H2S.	Hydrogen Sulfide	14-17	cystathionine beta-synthase	Homo sapiens	215-218
28440458-2	2017	As endogenous H2S exerts pro-cancer functions, inhibition of its production in cancer cells may provide a new cancer treatment strategy and be achieved via regulation of the function of cystathionine beta-synthase (CBS), one of the main metabolic enzymes synthesizing H2S.	Hydrogen Sulfide	268-271	cystathionine beta-synthase	Homo sapiens	186-213
28440458-2	2017	As endogenous H2S exerts pro-cancer functions, inhibition of its production in cancer cells may provide a new cancer treatment strategy and be achieved via regulation of the function of cystathionine beta-synthase (CBS), one of the main metabolic enzymes synthesizing H2S.	Hydrogen Sulfide	268-271	cystathionine beta-synthase	Homo sapiens	215-218
28440458-5	2017	When CBS was overexpressed in human hepatoma HepG2 and SMMC-7721 cells, inhibition of endogenous CBS/H2S significantly reduced their viability and growth rate, as well as the proliferation of SMMC-7721 cells.	smmc	55-59	cystathionine beta-synthase	Homo sapiens	5-8
28440458-5	2017	When CBS was overexpressed in human hepatoma HepG2 and SMMC-7721 cells, inhibition of endogenous CBS/H2S significantly reduced their viability and growth rate, as well as the proliferation of SMMC-7721 cells.	smmc	55-59	cystathionine beta-synthase	Homo sapiens	97-100
28440458-5	2017	When CBS was overexpressed in human hepatoma HepG2 and SMMC-7721 cells, inhibition of endogenous CBS/H2S significantly reduced their viability and growth rate, as well as the proliferation of SMMC-7721 cells.	Hydrogen Sulfide	101-104	cystathionine beta-synthase	Homo sapiens	5-8
28440458-5	2017	When CBS was overexpressed in human hepatoma HepG2 and SMMC-7721 cells, inhibition of endogenous CBS/H2S significantly reduced their viability and growth rate, as well as the proliferation of SMMC-7721 cells.	Hydrogen Sulfide	101-104	cystathionine beta-synthase	Homo sapiens	97-100
28440458-5	2017	When CBS was overexpressed in human hepatoma HepG2 and SMMC-7721 cells, inhibition of endogenous CBS/H2S significantly reduced their viability and growth rate, as well as the proliferation of SMMC-7721 cells.	smmc	192-196	cystathionine beta-synthase	Homo sapiens	5-8
28440458-5	2017	When CBS was overexpressed in human hepatoma HepG2 and SMMC-7721 cells, inhibition of endogenous CBS/H2S significantly reduced their viability and growth rate, as well as the proliferation of SMMC-7721 cells.	smmc	192-196	cystathionine beta-synthase	Homo sapiens	97-100
28440458-7	2017	Heme oxygenase-1 (HO-1; a microsomal enzyme) expression was significantly decreased while the reactive oxygen species (ROS) level was increased in the CBS siRNA-transfected SMMC-7721 cells.	Reactive Oxygen Species	94-117	cystathionine beta-synthase	Homo sapiens	151-154
28440458-7	2017	Heme oxygenase-1 (HO-1; a microsomal enzyme) expression was significantly decreased while the reactive oxygen species (ROS) level was increased in the CBS siRNA-transfected SMMC-7721 cells.	Reactive Oxygen Species	119-122	cystathionine beta-synthase	Homo sapiens	151-154
28440458-7	2017	Heme oxygenase-1 (HO-1; a microsomal enzyme) expression was significantly decreased while the reactive oxygen species (ROS) level was increased in the CBS siRNA-transfected SMMC-7721 cells.	smmc	173-177	cystathionine beta-synthase	Homo sapiens	151-154
28188160-3	2017	Our previous study has shown that human myometrium produces H2S via its generating enzymes cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthetase (CBS) during pregnancy.	Hydrogen Sulfide	60-63	cystathionine beta-synthase	Homo sapiens	127-156
28188160-3	2017	Our previous study has shown that human myometrium produces H2S via its generating enzymes cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthetase (CBS) during pregnancy.	Hydrogen Sulfide	60-63	cystathionine beta-synthase	Homo sapiens	158-161
28188160-12	2017	Knockdown of CSE and CBS prevented H2S suppression of inflammation.	Hydrogen Sulfide	35-38	cystathionine beta-synthase	Homo sapiens	21-24
28283345-7	2017	Notably, treatment with H2S donor, but not CBS activator, significantly reversed the impairments of LTP and fear memory caused by CBS inhibition.	Hydrogen Sulfide	24-27	cystathionine beta-synthase	Homo sapiens	130-133
28333381-3	2017	H2S is synthesized endogenously by three enzymes: cystathionine beta-synthase, cystathionine-gamma-lyase, and 3-mercaptopyruvate sulfurtransferase.	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	50-77
28199110-1	2017	Rate coefficients of H atom abstraction and H atom addition reactions of 3-hexene by the hydroxyl radicals were determined using both conventional transition-state theory and canonical variational transition-state theory, with the potential energy surface (PES) evaluated at the CCSD(T)/CBS//BHandHLYP/6-311G(d,p) level and quantum mechanical effect corrected by the compounded methods including one-dimensional Wigner method, multidimensional zero-curvature tunneling method, and small-curvature tunneling method.	trans-3-Hexene	73-81	cystathionine beta-synthase	Homo sapiens	287-290
28199110-1	2017	Rate coefficients of H atom abstraction and H atom addition reactions of 3-hexene by the hydroxyl radicals were determined using both conventional transition-state theory and canonical variational transition-state theory, with the potential energy surface (PES) evaluated at the CCSD(T)/CBS//BHandHLYP/6-311G(d,p) level and quantum mechanical effect corrected by the compounded methods including one-dimensional Wigner method, multidimensional zero-curvature tunneling method, and small-curvature tunneling method.	Hydroxyl Radical	89-106	cystathionine beta-synthase	Homo sapiens	287-290
28049024-9	2017	While simultaneous treatment with reactive persulfide and polysulfide, Na2S2 and Na2S4, blocked 1,4-NQ-dependent protein modification and HSF1 activation in A431 cells, the knockdown of Cys persulfide producing enzymes cystathionine beta-synthase (CBS) and/or cystathionine gamma-lyase (CSE) enhanced these phenomena.	cys persulfide	186-200	cystathionine beta-synthase	Homo sapiens	219-246
28108276-6	2017	Western blotting analysis shows that oxidative stress enhanced RAGE protein expression which was attenuated by either NaHS or over-expression of cystathionine beta-synthase (CBS), a critical enzyme for producing H2S in brain cells.	Hydrogen Sulfide	212-215	cystathionine beta-synthase	Homo sapiens	174-177
28087442-4	2017	Here, we found that the expression levels of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), two key enzymes in the generation of H2S, were significantly decreased in human degenerate NP tissues as well as in IL-1beta-treated NP cells.	Hydrogen Sulfide	153-156	cystathionine beta-synthase	Homo sapiens	45-72
28236844-9	2017	Vitamin D [1,25(OH)2D3] is known to induce the CBS gene expression while it can suppress the oxidative stress-induced COX-2 up-regulation and thromboxane production.	Vitamin D	0-9	cystathionine beta-synthase	Homo sapiens	47-50
28236844-9	2017	Vitamin D [1,25(OH)2D3] is known to induce the CBS gene expression while it can suppress the oxidative stress-induced COX-2 up-regulation and thromboxane production.	Calcitriol	11-22	cystathionine beta-synthase	Homo sapiens	47-50
28512525-8	2017	Increased expression of the H2S-producing enzymes cystathionine gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) in the heart, liver, and kidney tissues was observed in the NaHS-treated groups.	Hydrogen Sulfide	28-31	cystathionine beta-synthase	Homo sapiens	86-113
29927219-2	2017	Adipocyte endogenously produces H2S by cystathionine beta synthase (CBS), cystathionine gamma lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (MPST).The endogenous H2S in adipocyte plays an essential role in glucose uptake activity and utilization, lipolysis and adipocyte differentiation, and then takes part in the pathogenesis of obesity, diabetes and cardiovascular diseases.H2S regulates adipocyte energy metabolism by activation activating insulin receptor, peroxisome proliferator activated receptor gamma (PPARgamma) or potassium channel.	Hydrogen Sulfide	32-35	cystathionine beta-synthase	Homo sapiens	39-66
29927219-2	2017	Adipocyte endogenously produces H2S by cystathionine beta synthase (CBS), cystathionine gamma lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (MPST).The endogenous H2S in adipocyte plays an essential role in glucose uptake activity and utilization, lipolysis and adipocyte differentiation, and then takes part in the pathogenesis of obesity, diabetes and cardiovascular diseases.H2S regulates adipocyte energy metabolism by activation activating insulin receptor, peroxisome proliferator activated receptor gamma (PPARgamma) or potassium channel.	Hydrogen Sulfide	32-35	cystathionine beta-synthase	Homo sapiens	68-71
29927219-2	2017	Adipocyte endogenously produces H2S by cystathionine beta synthase (CBS), cystathionine gamma lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (MPST).The endogenous H2S in adipocyte plays an essential role in glucose uptake activity and utilization, lipolysis and adipocyte differentiation, and then takes part in the pathogenesis of obesity, diabetes and cardiovascular diseases.H2S regulates adipocyte energy metabolism by activation activating insulin receptor, peroxisome proliferator activated receptor gamma (PPARgamma) or potassium channel.	Hydrogen Sulfide	169-172	cystathionine beta-synthase	Homo sapiens	39-66
29927219-2	2017	Adipocyte endogenously produces H2S by cystathionine beta synthase (CBS), cystathionine gamma lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (MPST).The endogenous H2S in adipocyte plays an essential role in glucose uptake activity and utilization, lipolysis and adipocyte differentiation, and then takes part in the pathogenesis of obesity, diabetes and cardiovascular diseases.H2S regulates adipocyte energy metabolism by activation activating insulin receptor, peroxisome proliferator activated receptor gamma (PPARgamma) or potassium channel.	Hydrogen Sulfide	169-172	cystathionine beta-synthase	Homo sapiens	39-66
27935712-14	2017	As an external validation, the force field predicts interaction energies in good agreement with CCSD(T)/CBS values for dispersion-dominated dimers extracted from an HIV-II protease crystal structure with a bound ligand (indinavir).	Indinavir	220-229	cystathionine beta-synthase	Homo sapiens	104-107
28275971-1	2017	Extreme hyperhomocysteinemia with low cystathionine and cysteine is virtually diagnostic of cystathionine beta-synthase (CBS) deficiency since remethylation defects and hypermethioninemia due to other inborn errors cause elevated serum cystathionine.	Cystathionine	38-51	cystathionine beta-synthase	Homo sapiens	92-119
28275971-1	2017	Extreme hyperhomocysteinemia with low cystathionine and cysteine is virtually diagnostic of cystathionine beta-synthase (CBS) deficiency since remethylation defects and hypermethioninemia due to other inborn errors cause elevated serum cystathionine.	Cystathionine	38-51	cystathionine beta-synthase	Homo sapiens	121-124
28275971-1	2017	Extreme hyperhomocysteinemia with low cystathionine and cysteine is virtually diagnostic of cystathionine beta-synthase (CBS) deficiency since remethylation defects and hypermethioninemia due to other inborn errors cause elevated serum cystathionine.	Cysteine	17-25	cystathionine beta-synthase	Homo sapiens	92-119
28275971-1	2017	Extreme hyperhomocysteinemia with low cystathionine and cysteine is virtually diagnostic of cystathionine beta-synthase (CBS) deficiency since remethylation defects and hypermethioninemia due to other inborn errors cause elevated serum cystathionine.	Cysteine	17-25	cystathionine beta-synthase	Homo sapiens	121-124
28275971-1	2017	Extreme hyperhomocysteinemia with low cystathionine and cysteine is virtually diagnostic of cystathionine beta-synthase (CBS) deficiency since remethylation defects and hypermethioninemia due to other inborn errors cause elevated serum cystathionine.	Cystathionine	92-105	cystathionine beta-synthase	Homo sapiens	121-124
27930932-4	2017	RT-PCR and western blotting were performed to measure mRNA and protein levels of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) for H2S production.	Hydrogen Sulfide	155-158	cystathionine beta-synthase	Homo sapiens	81-108
28075397-3	2017	The reactions can be carried out by either cystathionine-beta-synthase (CBS) or cystathionine-gamma-lyase (CSE) independently, in the alternate reactions of the transsulfuration pathway devoted to hydrogen sulfide biosynthesis.	Hydrogen Sulfide	197-213	cystathionine beta-synthase	Homo sapiens	43-70
28075397-3	2017	The reactions can be carried out by either cystathionine-beta-synthase (CBS) or cystathionine-gamma-lyase (CSE) independently, in the alternate reactions of the transsulfuration pathway devoted to hydrogen sulfide biosynthesis.	Hydrogen Sulfide	197-213	cystathionine beta-synthase	Homo sapiens	72-75
28075397-7	2017	Lanthionine inhibits hydrogen sulfide production in hepatoma cells, possibly through CBS inhibition, thus providing some basis for the biochemical mechanism, which may significantly contribute to alterations of metabolism sulfur compounds in these subjects (e.g., high homocysteine and low hydrogen sulfide).	lanthionine	0-11	cystathionine beta-synthase	Homo sapiens	85-88
28291844-1	2017	Hydrogen sulfide (H2S) is endogenously synthesized from l-cysteine in reactions catalyzed by cystathionine beta-synthase (CBS, EC 4.2.1.22) and gamma-cystathionase (CSE, EC 4.4.1.1).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	93-120
28291844-1	2017	Hydrogen sulfide (H2S) is endogenously synthesized from l-cysteine in reactions catalyzed by cystathionine beta-synthase (CBS, EC 4.2.1.22) and gamma-cystathionase (CSE, EC 4.4.1.1).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	122-125
28291844-1	2017	Hydrogen sulfide (H2S) is endogenously synthesized from l-cysteine in reactions catalyzed by cystathionine beta-synthase (CBS, EC 4.2.1.22) and gamma-cystathionase (CSE, EC 4.4.1.1).	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	93-120
28291844-1	2017	Hydrogen sulfide (H2S) is endogenously synthesized from l-cysteine in reactions catalyzed by cystathionine beta-synthase (CBS, EC 4.2.1.22) and gamma-cystathionase (CSE, EC 4.4.1.1).	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	122-125
28291844-1	2017	Hydrogen sulfide (H2S) is endogenously synthesized from l-cysteine in reactions catalyzed by cystathionine beta-synthase (CBS, EC 4.2.1.22) and gamma-cystathionase (CSE, EC 4.4.1.1).	Cysteine	56-66	cystathionine beta-synthase	Homo sapiens	93-120
28291844-1	2017	Hydrogen sulfide (H2S) is endogenously synthesized from l-cysteine in reactions catalyzed by cystathionine beta-synthase (CBS, EC 4.2.1.22) and gamma-cystathionase (CSE, EC 4.4.1.1).	Cysteine	56-66	cystathionine beta-synthase	Homo sapiens	122-125
28291844-5	2017	The RP-HPLC method was used to determine the concentration of cystathionine and alpha-ketobutyrate, products of the CBS- and CTH-catalyzed reactions.	Cystathionine	62-75	cystathionine beta-synthase	Homo sapiens	116-119
28291844-5	2017	The RP-HPLC method was used to determine the concentration of cystathionine and alpha-ketobutyrate, products of the CBS- and CTH-catalyzed reactions.	2-oxobutanoate	80-98	cystathionine beta-synthase	Homo sapiens	116-119
28291844-7	2017	The higher expression and activity of CBS, CTH and MPST in the neuroblastoma cells were associated with more intensive generation of H2S in the presence of 2 mM cysteine.	Hydrogen Sulfide	133-136	cystathionine beta-synthase	Homo sapiens	38-41
28291844-7	2017	The higher expression and activity of CBS, CTH and MPST in the neuroblastoma cells were associated with more intensive generation of H2S in the presence of 2 mM cysteine.	Cysteine	161-169	cystathionine beta-synthase	Homo sapiens	38-41
27778219-1	2017	Cystathionine beta-synthase (CBS) deficiency is a rare inherited disorder in the methionine catabolic pathway, in which the impaired synthesis of cystathionine leads to accumulation of homocysteine.	Methionine	81-91	cystathionine beta-synthase	Homo sapiens	0-27
27778219-1	2017	Cystathionine beta-synthase (CBS) deficiency is a rare inherited disorder in the methionine catabolic pathway, in which the impaired synthesis of cystathionine leads to accumulation of homocysteine.	Cystathionine	146-159	cystathionine beta-synthase	Homo sapiens	0-27
27778219-1	2017	Cystathionine beta-synthase (CBS) deficiency is a rare inherited disorder in the methionine catabolic pathway, in which the impaired synthesis of cystathionine leads to accumulation of homocysteine.	Homocysteine	185-197	cystathionine beta-synthase	Homo sapiens	0-27
28421128-0	2017	A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine beta-Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity?	Hydrogen Sulfide	43-59	cystathionine beta-synthase	Homo sapiens	80-107
28421128-1	2017	The human disease classical homocystinuria results from mutations in the gene encoding the pyridoxal 5"-phosphate- (PLP-) dependent cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration pathway that controls homocysteine levels, and is a major source of the signaling molecule hydrogen sulfide (H2S).	Pyridoxal Phosphate	91-113	cystathionine beta-synthase	Homo sapiens	132-159
28421128-1	2017	The human disease classical homocystinuria results from mutations in the gene encoding the pyridoxal 5"-phosphate- (PLP-) dependent cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration pathway that controls homocysteine levels, and is a major source of the signaling molecule hydrogen sulfide (H2S).	Pyridoxal Phosphate	91-113	cystathionine beta-synthase	Homo sapiens	161-164
28421128-1	2017	The human disease classical homocystinuria results from mutations in the gene encoding the pyridoxal 5"-phosphate- (PLP-) dependent cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration pathway that controls homocysteine levels, and is a major source of the signaling molecule hydrogen sulfide (H2S).	Homocysteine	226-238	cystathionine beta-synthase	Homo sapiens	132-159
28421128-1	2017	The human disease classical homocystinuria results from mutations in the gene encoding the pyridoxal 5"-phosphate- (PLP-) dependent cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration pathway that controls homocysteine levels, and is a major source of the signaling molecule hydrogen sulfide (H2S).	Homocysteine	226-238	cystathionine beta-synthase	Homo sapiens	161-164
28421128-1	2017	The human disease classical homocystinuria results from mutations in the gene encoding the pyridoxal 5"-phosphate- (PLP-) dependent cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration pathway that controls homocysteine levels, and is a major source of the signaling molecule hydrogen sulfide (H2S).	Hydrogen Sulfide	295-311	cystathionine beta-synthase	Homo sapiens	132-159
28421128-1	2017	The human disease classical homocystinuria results from mutations in the gene encoding the pyridoxal 5"-phosphate- (PLP-) dependent cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration pathway that controls homocysteine levels, and is a major source of the signaling molecule hydrogen sulfide (H2S).	Hydrogen Sulfide	295-311	cystathionine beta-synthase	Homo sapiens	161-164
28421128-1	2017	The human disease classical homocystinuria results from mutations in the gene encoding the pyridoxal 5"-phosphate- (PLP-) dependent cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration pathway that controls homocysteine levels, and is a major source of the signaling molecule hydrogen sulfide (H2S).	Hydrogen Sulfide	313-316	cystathionine beta-synthase	Homo sapiens	132-159
28421128-1	2017	The human disease classical homocystinuria results from mutations in the gene encoding the pyridoxal 5"-phosphate- (PLP-) dependent cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration pathway that controls homocysteine levels, and is a major source of the signaling molecule hydrogen sulfide (H2S).	Hydrogen Sulfide	313-316	cystathionine beta-synthase	Homo sapiens	161-164
28421128-2	2017	CBS activity, contributing to cellular redox homeostasis, is positively regulated by S-adenosyl-L-methionine (AdoMet) but fully inhibited upon CO or NO  binding to a noncatalytic heme moiety.	S-Adenosylmethionine	85-108	cystathionine beta-synthase	Homo sapiens	0-3
28421128-2	2017	CBS activity, contributing to cellular redox homeostasis, is positively regulated by S-adenosyl-L-methionine (AdoMet) but fully inhibited upon CO or NO  binding to a noncatalytic heme moiety.	S-Adenosylmethionine	110-116	cystathionine beta-synthase	Homo sapiens	0-3
28421128-2	2017	CBS activity, contributing to cellular redox homeostasis, is positively regulated by S-adenosyl-L-methionine (AdoMet) but fully inhibited upon CO or NO  binding to a noncatalytic heme moiety.	Heme	179-183	cystathionine beta-synthase	Homo sapiens	0-3
28512525-8	2017	Increased expression of the H2S-producing enzymes cystathionine gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) in the heart, liver, and kidney tissues was observed in the NaHS-treated groups.	sodium bisulfide	180-184	cystathionine beta-synthase	Homo sapiens	86-113
26316071-11	2016	In conclusion, the expression of hydrogen sulfide synthesis enzymes, cystathionine-beta-synthase and cystathionine-gamma-lyase, can be detected in human esophagus and is reduced in patients with achalasia, which implicates the involvement of the two hydrogen sulfide synthesis enzymes in the pathophysiology of achalasia.	Hydrogen Sulfide	33-49	cystathionine beta-synthase	Homo sapiens	69-96
28421128-4	2017	Here we found that the ferrous heme of the reportedly mild p.P49L CBS variant has altered spectral properties and markedly increased affinity for CO, making the protein much more prone than wild type (WT) CBS to inactivation at physiological CO levels.	ferrous heme	23-35	cystathionine beta-synthase	Homo sapiens	66-69
28421128-4	2017	Here we found that the ferrous heme of the reportedly mild p.P49L CBS variant has altered spectral properties and markedly increased affinity for CO, making the protein much more prone than wild type (WT) CBS to inactivation at physiological CO levels.	ferrous heme	23-35	cystathionine beta-synthase	Homo sapiens	205-208
28421128-4	2017	Here we found that the ferrous heme of the reportedly mild p.P49L CBS variant has altered spectral properties and markedly increased affinity for CO, making the protein much more prone than wild type (WT) CBS to inactivation at physiological CO levels.	Carbon Monoxide	146-148	cystathionine beta-synthase	Homo sapiens	66-69
28421128-4	2017	Here we found that the ferrous heme of the reportedly mild p.P49L CBS variant has altered spectral properties and markedly increased affinity for CO, making the protein much more prone than wild type (WT) CBS to inactivation at physiological CO levels.	Carbon Monoxide	146-148	cystathionine beta-synthase	Homo sapiens	205-208
27983699-3	2016	That cystathionine beta-synthase and cystathionine gamma-lyase produced CysSSH from cystine was recently demonstrated.	Cystine	84-91	cystathionine beta-synthase	Homo sapiens	5-32
27924828-0	2016	rpL3 promotes the apoptosis of p53 mutated lung cancer cells by down-regulating CBS and NFkappaB upon 5-FU treatment.	Fluorouracil	102-106	cystathionine beta-synthase	Homo sapiens	80-83
27924828-2	2016	In the present study, we reporte that rpL3 induced by 5-FU treatment in Calu-6 cells represses CBS transcription and reduces CBS protein stability leading to a decrease of CBS protein levels.	Fluorouracil	54-58	cystathionine beta-synthase	Homo sapiens	95-98
27924828-2	2016	In the present study, we reporte that rpL3 induced by 5-FU treatment in Calu-6 cells represses CBS transcription and reduces CBS protein stability leading to a decrease of CBS protein levels.	Fluorouracil	54-58	cystathionine beta-synthase	Homo sapiens	125-128
27924828-2	2016	In the present study, we reporte that rpL3 induced by 5-FU treatment in Calu-6 cells represses CBS transcription and reduces CBS protein stability leading to a decrease of CBS protein levels.	Fluorouracil	54-58	cystathionine beta-synthase	Homo sapiens	125-128
27861796-1	2016	Cystathionine beta-synthase (CBS) plays a key role in the metabolism of sulfur-containing amino acids.	Sulfur	72-78	cystathionine beta-synthase	Homo sapiens	0-27
30108705-0	2017	Discovery of selective cystathionine beta-synthase inhibitors by high-throughput screening with a fluorescent thiol probe.	Sulfhydryl Compounds	110-115	cystathionine beta-synthase	Homo sapiens	23-50
30108705-1	2017	A high-throughput assay was developed to identify inhibitors of cystathionine beta-synthase (CBS), which is one of three key enzymes involved in H2S biosynthesis.	Hydrogen Sulfide	145-148	cystathionine beta-synthase	Homo sapiens	64-91
30108705-1	2017	A high-throughput assay was developed to identify inhibitors of cystathionine beta-synthase (CBS), which is one of three key enzymes involved in H2S biosynthesis.	Hydrogen Sulfide	145-148	cystathionine beta-synthase	Homo sapiens	93-96
27521834-6	2016	Hexachlorophene (IC50: ~60muM), tannic acid (IC50: ~40muM) and benserazide (IC50: ~30muM) were less potent CBS inhibitors than the two reference compounds AOAA (IC50: ~3muM) and NSC67078 (IC50: ~1muM), while aurintricarboxylic acid (IC50: ~3muM) was equipotent with AOAA.	Hexachlorophene	0-15	cystathionine beta-synthase	Homo sapiens	107-110
27521834-6	2016	Hexachlorophene (IC50: ~60muM), tannic acid (IC50: ~40muM) and benserazide (IC50: ~30muM) were less potent CBS inhibitors than the two reference compounds AOAA (IC50: ~3muM) and NSC67078 (IC50: ~1muM), while aurintricarboxylic acid (IC50: ~3muM) was equipotent with AOAA.	Tannins	32-43	cystathionine beta-synthase	Homo sapiens	107-110
27521834-6	2016	Hexachlorophene (IC50: ~60muM), tannic acid (IC50: ~40muM) and benserazide (IC50: ~30muM) were less potent CBS inhibitors than the two reference compounds AOAA (IC50: ~3muM) and NSC67078 (IC50: ~1muM), while aurintricarboxylic acid (IC50: ~3muM) was equipotent with AOAA.	Benserazide	63-74	cystathionine beta-synthase	Homo sapiens	107-110
27521834-6	2016	Hexachlorophene (IC50: ~60muM), tannic acid (IC50: ~40muM) and benserazide (IC50: ~30muM) were less potent CBS inhibitors than the two reference compounds AOAA (IC50: ~3muM) and NSC67078 (IC50: ~1muM), while aurintricarboxylic acid (IC50: ~3muM) was equipotent with AOAA.	Aminooxyacetic Acid	155-159	cystathionine beta-synthase	Homo sapiens	107-110
27521834-6	2016	Hexachlorophene (IC50: ~60muM), tannic acid (IC50: ~40muM) and benserazide (IC50: ~30muM) were less potent CBS inhibitors than the two reference compounds AOAA (IC50: ~3muM) and NSC67078 (IC50: ~1muM), while aurintricarboxylic acid (IC50: ~3muM) was equipotent with AOAA.	Aurintricarboxylic Acid	208-231	cystathionine beta-synthase	Homo sapiens	107-110
27521834-7	2016	The second reference compound NSC67078 not only inhibited the CBS-induced AzMC fluorescence signal (IC50: ~1muM), but also inhibited with the GYY4137-induced AzMC fluorescence signal with (IC50 of ~6muM) indicative of scavenging/non-specific effects.	azmc	74-78	cystathionine beta-synthase	Homo sapiens	62-65
27521834-10	2016	Copper-containing compounds present in the libraries, were also found to be potent inhibitors of recombinant CBS; however this activity was due to the CBS inhibitory effect of copper ions themselves.	Copper	0-6	cystathionine beta-synthase	Homo sapiens	109-112
27521834-10	2016	Copper-containing compounds present in the libraries, were also found to be potent inhibitors of recombinant CBS; however this activity was due to the CBS inhibitory effect of copper ions themselves.	Copper	0-6	cystathionine beta-synthase	Homo sapiens	151-154
27521834-10	2016	Copper-containing compounds present in the libraries, were also found to be potent inhibitors of recombinant CBS; however this activity was due to the CBS inhibitory effect of copper ions themselves.	Copper	176-182	cystathionine beta-synthase	Homo sapiens	109-112
27521834-10	2016	Copper-containing compounds present in the libraries, were also found to be potent inhibitors of recombinant CBS; however this activity was due to the CBS inhibitory effect of copper ions themselves.	Copper	176-182	cystathionine beta-synthase	Homo sapiens	151-154
27521834-13	2016	Benserazide suppressed HCT116 mitochondrial function and inhibited proliferation of the high CBS-expressing colon cancer cell line HT29, but not the low CBS-expressing line, LoVo.	Benserazide	0-11	cystathionine beta-synthase	Homo sapiens	93-96
27521834-14	2016	The major benserazide metabolite 2,3,4-trihydroxybenzylhydrazine also inhibited CBS activity and suppressed HCT116 cell proliferation in vitro.	Benserazide	10-21	cystathionine beta-synthase	Homo sapiens	80-83
27521834-14	2016	The major benserazide metabolite 2,3,4-trihydroxybenzylhydrazine also inhibited CBS activity and suppressed HCT116 cell proliferation in vitro.	2,3,4-trihydroxybenzylhydrazine	33-64	cystathionine beta-synthase	Homo sapiens	80-83
27521834-18	2016	We conclude that benserazide inhibits CBS activity and suppresses colon cancer cell proliferation and bioenergetics in vitro, and tumor growth in vivo.	Benserazide	17-28	cystathionine beta-synthase	Homo sapiens	38-41
27931022-1	2017	BACKGROUND: Hydrogen sulfide (H2S), a gasotransmitter, is generated from L-cysteine by mainly 3 enzymes, cystathionine-gamma-lyase (CSE), cystathionine-beta-synthase, and 3-mercaptopyruvate sulfurtransferase in cooperation with cysteine aminotransferase.	Hydrogen Sulfide	12-28	cystathionine beta-synthase	Homo sapiens	138-165
27931022-1	2017	BACKGROUND: Hydrogen sulfide (H2S), a gasotransmitter, is generated from L-cysteine by mainly 3 enzymes, cystathionine-gamma-lyase (CSE), cystathionine-beta-synthase, and 3-mercaptopyruvate sulfurtransferase in cooperation with cysteine aminotransferase.	Hydrogen Sulfide	30-33	cystathionine beta-synthase	Homo sapiens	138-165
27931022-1	2017	BACKGROUND: Hydrogen sulfide (H2S), a gasotransmitter, is generated from L-cysteine by mainly 3 enzymes, cystathionine-gamma-lyase (CSE), cystathionine-beta-synthase, and 3-mercaptopyruvate sulfurtransferase in cooperation with cysteine aminotransferase.	Cysteine	73-83	cystathionine beta-synthase	Homo sapiens	138-165
27808278-2	2016	Here we show that human lung adenocarcinoma tissue expresses high levels of hydrogen sulfide (H2S) producing enzymes, namely, cystathionine beta-synthase (CBS), cystathionine gamma lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST), in comparison to adjacent lung tissue.	Hydrogen Sulfide	76-92	cystathionine beta-synthase	Homo sapiens	126-153
27808278-2	2016	Here we show that human lung adenocarcinoma tissue expresses high levels of hydrogen sulfide (H2S) producing enzymes, namely, cystathionine beta-synthase (CBS), cystathionine gamma lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST), in comparison to adjacent lung tissue.	Hydrogen Sulfide	76-92	cystathionine beta-synthase	Homo sapiens	155-158
27808278-2	2016	Here we show that human lung adenocarcinoma tissue expresses high levels of hydrogen sulfide (H2S) producing enzymes, namely, cystathionine beta-synthase (CBS), cystathionine gamma lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST), in comparison to adjacent lung tissue.	Hydrogen Sulfide	94-97	cystathionine beta-synthase	Homo sapiens	126-153
27808278-2	2016	Here we show that human lung adenocarcinoma tissue expresses high levels of hydrogen sulfide (H2S) producing enzymes, namely, cystathionine beta-synthase (CBS), cystathionine gamma lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST), in comparison to adjacent lung tissue.	Hydrogen Sulfide	94-97	cystathionine beta-synthase	Homo sapiens	155-158
27530978-1	2016	Cystathionine beta-synthase (CBS) deficiency, a genetic disorder in homocysteine (Hcy) metabolism in humans, elevates plasma Hcy-thiolactone and leads to connective tissue abnormalities that affect the cardiovascular and skeletal systems.	Homocysteine	68-80	cystathionine beta-synthase	Homo sapiens	0-27
27530978-1	2016	Cystathionine beta-synthase (CBS) deficiency, a genetic disorder in homocysteine (Hcy) metabolism in humans, elevates plasma Hcy-thiolactone and leads to connective tissue abnormalities that affect the cardiovascular and skeletal systems.	Homocysteine	82-85	cystathionine beta-synthase	Homo sapiens	0-27
27530978-1	2016	Cystathionine beta-synthase (CBS) deficiency, a genetic disorder in homocysteine (Hcy) metabolism in humans, elevates plasma Hcy-thiolactone and leads to connective tissue abnormalities that affect the cardiovascular and skeletal systems.	homocysteine thiolactone	125-140	cystathionine beta-synthase	Homo sapiens	0-27
27521834-0	2016	Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine beta-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer.	Benserazide	161-172	cystathionine beta-synthase	Homo sapiens	111-138
27521834-5	2016	Four compounds, hexachlorophene, tannic acid, aurintricarboxylic acid and benserazide showed concentration-dependent CBS inhibitory actions without scavenging H2S released from GYY4137, identifying them as direct CBS inhibitors.	Hexachlorophene	16-31	cystathionine beta-synthase	Homo sapiens	117-120
27521834-5	2016	Four compounds, hexachlorophene, tannic acid, aurintricarboxylic acid and benserazide showed concentration-dependent CBS inhibitory actions without scavenging H2S released from GYY4137, identifying them as direct CBS inhibitors.	Hexachlorophene	16-31	cystathionine beta-synthase	Homo sapiens	213-216
27521834-5	2016	Four compounds, hexachlorophene, tannic acid, aurintricarboxylic acid and benserazide showed concentration-dependent CBS inhibitory actions without scavenging H2S released from GYY4137, identifying them as direct CBS inhibitors.	Tannins	33-44	cystathionine beta-synthase	Homo sapiens	117-120
27521834-5	2016	Four compounds, hexachlorophene, tannic acid, aurintricarboxylic acid and benserazide showed concentration-dependent CBS inhibitory actions without scavenging H2S released from GYY4137, identifying them as direct CBS inhibitors.	Tannins	33-44	cystathionine beta-synthase	Homo sapiens	213-216
27521834-5	2016	Four compounds, hexachlorophene, tannic acid, aurintricarboxylic acid and benserazide showed concentration-dependent CBS inhibitory actions without scavenging H2S released from GYY4137, identifying them as direct CBS inhibitors.	Aurintricarboxylic Acid	46-69	cystathionine beta-synthase	Homo sapiens	117-120
27521834-5	2016	Four compounds, hexachlorophene, tannic acid, aurintricarboxylic acid and benserazide showed concentration-dependent CBS inhibitory actions without scavenging H2S released from GYY4137, identifying them as direct CBS inhibitors.	Aurintricarboxylic Acid	46-69	cystathionine beta-synthase	Homo sapiens	213-216
27521834-5	2016	Four compounds, hexachlorophene, tannic acid, aurintricarboxylic acid and benserazide showed concentration-dependent CBS inhibitory actions without scavenging H2S released from GYY4137, identifying them as direct CBS inhibitors.	Benserazide	74-85	cystathionine beta-synthase	Homo sapiens	117-120
27521834-5	2016	Four compounds, hexachlorophene, tannic acid, aurintricarboxylic acid and benserazide showed concentration-dependent CBS inhibitory actions without scavenging H2S released from GYY4137, identifying them as direct CBS inhibitors.	Benserazide	74-85	cystathionine beta-synthase	Homo sapiens	213-216
27664576-7	2016	Interestingly, the sub-cytotoxic formaldehyde affected NHKs to upregulate two enzymes important in the cellular transsulfuration pathway, cystathionine gamma-lyase (CTH) and cystathionine-beta-synthase (CBS).	Formaldehyde	33-45	cystathionine beta-synthase	Homo sapiens	174-201
27664576-7	2016	Interestingly, the sub-cytotoxic formaldehyde affected NHKs to upregulate two enzymes important in the cellular transsulfuration pathway, cystathionine gamma-lyase (CTH) and cystathionine-beta-synthase (CBS).	Formaldehyde	33-45	cystathionine beta-synthase	Homo sapiens	203-206
27664576-9	2016	The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs.	Cystathionine	32-47	cystathionine beta-synthase	Homo sapiens	187-190
27664576-9	2016	The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs.	Cysteine	52-62	cystathionine beta-synthase	Homo sapiens	187-190
27664576-9	2016	The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs.	Formaldehyde	79-91	cystathionine beta-synthase	Homo sapiens	27-30
27664576-9	2016	The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs.	Formaldehyde	79-91	cystathionine beta-synthase	Homo sapiens	187-190
27664576-9	2016	The metabolites of CTH and CBS, l-cystathionine and l-cysteine, attenuated the formaldehyde-induced upregulation of pro-inflammatory DEGs, MMP1, PTGS2, and CXCL8, suggesting that CTH and CBS play a role in the negative feedback regulation of formaldehyde-induced pro-inflammatory responses in NHKs.	Formaldehyde	242-254	cystathionine beta-synthase	Homo sapiens	27-30
27664576-10	2016	In this regard, the sub-cytotoxic formaldehyde-induced CBS and CTH may regulate inflammation fate decision to resolution by suppressing the early pro-inflammatory response.	Formaldehyde	34-46	cystathionine beta-synthase	Homo sapiens	55-58
26316071-11	2016	In conclusion, the expression of hydrogen sulfide synthesis enzymes, cystathionine-beta-synthase and cystathionine-gamma-lyase, can be detected in human esophagus and is reduced in patients with achalasia, which implicates the involvement of the two hydrogen sulfide synthesis enzymes in the pathophysiology of achalasia.	Hydrogen Sulfide	250-266	cystathionine beta-synthase	Homo sapiens	69-96
27440715-9	2016	Pretreatment with the cystathionine-gamma-lyase inhibitor d/l-propargylglycine (PAG) decreased hypoxic inhibition of sodium transport by H441 monolayers, whereas inhibition of cystathionine-beta-synthase (with aminooxy-acetic acid; AOAA) or 3-mercaptopyruvate sulfurtransferase (with aspartate) had no effect.	Deuterium	58-59	cystathionine beta-synthase	Homo sapiens	176-203
27711596-2	2016	Calculated at the very accurate CCSD(T)/CBS level of theory, the cyclohexane-benzene interaction energy is -3.27 kcal mol-1, which is significantly stronger than the interaction in the benzene dimer (-2.84 kcal mol-1) indicating the importance of aliphatic-aromatic interactions.	Cyclohexane	65-76	cystathionine beta-synthase	Homo sapiens	40-43
27711596-2	2016	Calculated at the very accurate CCSD(T)/CBS level of theory, the cyclohexane-benzene interaction energy is -3.27 kcal mol-1, which is significantly stronger than the interaction in the benzene dimer (-2.84 kcal mol-1) indicating the importance of aliphatic-aromatic interactions.	Benzene	77-84	cystathionine beta-synthase	Homo sapiens	40-43
27711596-2	2016	Calculated at the very accurate CCSD(T)/CBS level of theory, the cyclohexane-benzene interaction energy is -3.27 kcal mol-1, which is significantly stronger than the interaction in the benzene dimer (-2.84 kcal mol-1) indicating the importance of aliphatic-aromatic interactions.	Benzene	185-192	cystathionine beta-synthase	Homo sapiens	40-43
27472293-5	2016	Cystathionine beta-synthase (CBS)-siRNA transfection further demonstrated that endogenous H2S system involves in DSS-induced inflammation and mediates barrier function.	Hydrogen Sulfide	90-93	cystathionine beta-synthase	Homo sapiens	0-27
27472293-5	2016	Cystathionine beta-synthase (CBS)-siRNA transfection further demonstrated that endogenous H2S system involves in DSS-induced inflammation and mediates barrier function.	Hydrogen Sulfide	90-93	cystathionine beta-synthase	Homo sapiens	29-32
27311614-2	2016	The accumulation of CTH, specifically in HBC, was attributed to the overexpression of cystathionine beta synthase (CBS), its synthesizing enzyme, and the undetectable levels of its downstream metabolizing enzyme, cystathionine gamma lyase (CGL).	Cystathionine	20-23	cystathionine beta-synthase	Homo sapiens	86-113
27257787-0	2016	Cystathionine-beta-synthase inhibition for colon cancer: Enhancement of the efficacy of aminooxyacetic acid via the prodrug approach.	Aminooxyacetic Acid	88-107	cystathionine beta-synthase	Homo sapiens	0-27
27475883-3	2016	A reduction of the expression/function of the two major hydrogen sulfide (H2S)-producing enzymes, cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS), has also been demonstrated.	Hydrogen Sulfide	56-72	cystathionine beta-synthase	Homo sapiens	134-161
27475883-3	2016	A reduction of the expression/function of the two major hydrogen sulfide (H2S)-producing enzymes, cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS), has also been demonstrated.	Hydrogen Sulfide	74-77	cystathionine beta-synthase	Homo sapiens	134-161
27311614-2	2016	The accumulation of CTH, specifically in HBC, was attributed to the overexpression of cystathionine beta synthase (CBS), its synthesizing enzyme, and the undetectable levels of its downstream metabolizing enzyme, cystathionine gamma lyase (CGL).	Cystathionine	20-23	cystathionine beta-synthase	Homo sapiens	115-118
27430865-6	2016	Calculations at SCS-MP2/CBS-level of theory and experimental data of the dienamine formation show kinetic preference for the Z-isomer of the second double bond and a slow isomerization toward the thermodynamically preferred E-isomer.	dienamine	73-82	cystathionine beta-synthase	Homo sapiens	24-27
27509878-0	2016	Urothelium muscarinic activation phosphorylates CBS(Ser227) via cGMP/PKG pathway causing human bladder relaxation through H2S production.	Cyclic GMP	64-68	cystathionine beta-synthase	Homo sapiens	48-51
27509878-0	2016	Urothelium muscarinic activation phosphorylates CBS(Ser227) via cGMP/PKG pathway causing human bladder relaxation through H2S production.	Hydrogen Sulfide	122-125	cystathionine beta-synthase	Homo sapiens	48-51
27509878-7	2016	In the functional studies, the urothelium removal from human bladder strips leads to an increase in carbachol-induced contraction that is mimicked by CBS inhibition.	Carbachol	100-109	cystathionine beta-synthase	Homo sapiens	150-153
27509878-9	2016	The increase in H2S production and in turn of cGMP is driven by CBS-cGMP/PKG-dependent phosphorylation at Ser(227) following carbachol stimulation.	Hydrogen Sulfide	16-19	cystathionine beta-synthase	Homo sapiens	64-67
27509878-9	2016	The increase in H2S production and in turn of cGMP is driven by CBS-cGMP/PKG-dependent phosphorylation at Ser(227) following carbachol stimulation.	Cyclic GMP	46-50	cystathionine beta-synthase	Homo sapiens	64-67
27129884-2	2016	Among uremic toxins, homocysteine and cysteine are both substrates of cystathionine beta-synthase and cystathionine gamma-lyase in hydrogen sulfide biosynthesis, leading to the formation of two sulfur metabolites, lanthionine and homolanthionine, considered stable indirect biomarkers of its production.	Homocysteine	21-33	cystathionine beta-synthase	Homo sapiens	70-97
27509878-9	2016	The increase in H2S production and in turn of cGMP is driven by CBS-cGMP/PKG-dependent phosphorylation at Ser(227) following carbachol stimulation.	Cyclic GMP	68-72	cystathionine beta-synthase	Homo sapiens	64-67
27509878-9	2016	The increase in H2S production and in turn of cGMP is driven by CBS-cGMP/PKG-dependent phosphorylation at Ser(227) following carbachol stimulation.	Serine	106-109	cystathionine beta-synthase	Homo sapiens	64-67
27509878-9	2016	The increase in H2S production and in turn of cGMP is driven by CBS-cGMP/PKG-dependent phosphorylation at Ser(227) following carbachol stimulation.	Carbachol	125-134	cystathionine beta-synthase	Homo sapiens	64-67
27365395-6	2016	This metabolite switch from cystathionine to cysteine and/or homocysteine renders H2S synthesis by CSE responsive to the known modulators of CBS: S-adenosylmethionine, NO, and CO. Used acutely, it regulates H2S synthesis; used chronically, it might contribute to disease pathology.	S-Adenosylmethionine	148-166	cystathionine beta-synthase	Homo sapiens	141-144
27365395-6	2016	This metabolite switch from cystathionine to cysteine and/or homocysteine renders H2S synthesis by CSE responsive to the known modulators of CBS: S-adenosylmethionine, NO, and CO. Used acutely, it regulates H2S synthesis; used chronically, it might contribute to disease pathology.	Hydrogen Sulfide	207-210	cystathionine beta-synthase	Homo sapiens	141-144
27035752-2	2016	Endogenous H2S is synthesized from l-cysteine via cystathionine beta-synthase and cystathionine gamma-lyase and it regulates multiple signaling pathways in mammalian cells.	Hydrogen Sulfide	11-14	cystathionine beta-synthase	Homo sapiens	50-77
27035752-2	2016	Endogenous H2S is synthesized from l-cysteine via cystathionine beta-synthase and cystathionine gamma-lyase and it regulates multiple signaling pathways in mammalian cells.	Cysteine	35-45	cystathionine beta-synthase	Homo sapiens	50-77
27035752-10	2016	RESULTS: In this study, we show that H2S is produced by human PDLCs via the cystathionine beta-synthase/cystathionine gamma-lyase pathway to promote their osteogenic differentiation.	Hydrogen Sulfide	37-40	cystathionine beta-synthase	Homo sapiens	76-103
26791043-1	2016	Two enzymes in the transsulfuration pathway of homocysteine -cystathionine beta-synthase (CBS) and gamma-cystathionase (CTH)-use cysteine and/or homocysteine to produce the important signaling molecule hydrogen sulfide (H2S) and simultaneously the thioethers lanthionine, cystathionine or homolanthionine.	Cystathionine	61-74	cystathionine beta-synthase	Homo sapiens	90-93
26791043-1	2016	Two enzymes in the transsulfuration pathway of homocysteine -cystathionine beta-synthase (CBS) and gamma-cystathionase (CTH)-use cysteine and/or homocysteine to produce the important signaling molecule hydrogen sulfide (H2S) and simultaneously the thioethers lanthionine, cystathionine or homolanthionine.	L-Homolanthionine	289-304	cystathionine beta-synthase	Homo sapiens	61-88
26791043-1	2016	Two enzymes in the transsulfuration pathway of homocysteine -cystathionine beta-synthase (CBS) and gamma-cystathionase (CTH)-use cysteine and/or homocysteine to produce the important signaling molecule hydrogen sulfide (H2S) and simultaneously the thioethers lanthionine, cystathionine or homolanthionine.	L-Homolanthionine	289-304	cystathionine beta-synthase	Homo sapiens	90-93
26791043-4	2016	Since chaperoned recombinant mutant CBS enzymes retained capacity of H2S synthesis in vitro it can be stipulated that deficient CBS activity in vivo may impair H2S production.	Hydrogen Sulfide	69-72	cystathionine beta-synthase	Homo sapiens	36-39
26791043-4	2016	Since chaperoned recombinant mutant CBS enzymes retained capacity of H2S synthesis in vitro it can be stipulated that deficient CBS activity in vivo may impair H2S production.	Hydrogen Sulfide	160-163	cystathionine beta-synthase	Homo sapiens	36-39
26791043-7	2016	In the remethylation defects the accumulation of homocysteine and the increased flux of metabolites through the transsulfuration pathway resulted in elevation of cystathionine and homolanthionine (857% and 400% of median control values, respectively) indicating a possibility of an increased biosynthesis of H2S by both CBS and CTH.	Homocysteine	49-61	cystathionine beta-synthase	Homo sapiens	320-323
26791043-7	2016	In the remethylation defects the accumulation of homocysteine and the increased flux of metabolites through the transsulfuration pathway resulted in elevation of cystathionine and homolanthionine (857% and 400% of median control values, respectively) indicating a possibility of an increased biosynthesis of H2S by both CBS and CTH.	Cystathionine	162-175	cystathionine beta-synthase	Homo sapiens	320-323
26805382-0	2016	Kinetic stability of cystathionine beta-synthase can be modulated by structural analogs of S-adenosylmethionine: Potential approach to pharmacological chaperone therapy for homocystinuria.	S-Adenosylmethionine	91-111	cystathionine beta-synthase	Homo sapiens	21-48
27365395-3	2016	We demonstrate that a kinetically controlled heme-dependent metabolite switch in CBS regulates these competing reactions where by cystathionine, the product of CBS, inhibits H2S synthesis by the second enzyme, CSE.	Heme	45-49	cystathionine beta-synthase	Homo sapiens	81-84
27365395-3	2016	We demonstrate that a kinetically controlled heme-dependent metabolite switch in CBS regulates these competing reactions where by cystathionine, the product of CBS, inhibits H2S synthesis by the second enzyme, CSE.	Heme	45-49	cystathionine beta-synthase	Homo sapiens	160-163
27365395-3	2016	We demonstrate that a kinetically controlled heme-dependent metabolite switch in CBS regulates these competing reactions where by cystathionine, the product of CBS, inhibits H2S synthesis by the second enzyme, CSE.	Cystathionine	130-143	cystathionine beta-synthase	Homo sapiens	81-84
27365395-3	2016	We demonstrate that a kinetically controlled heme-dependent metabolite switch in CBS regulates these competing reactions where by cystathionine, the product of CBS, inhibits H2S synthesis by the second enzyme, CSE.	Cystathionine	130-143	cystathionine beta-synthase	Homo sapiens	160-163
27365395-3	2016	We demonstrate that a kinetically controlled heme-dependent metabolite switch in CBS regulates these competing reactions where by cystathionine, the product of CBS, inhibits H2S synthesis by the second enzyme, CSE.	Hydrogen Sulfide	174-177	cystathionine beta-synthase	Homo sapiens	81-84
27365395-3	2016	We demonstrate that a kinetically controlled heme-dependent metabolite switch in CBS regulates these competing reactions where by cystathionine, the product of CBS, inhibits H2S synthesis by the second enzyme, CSE.	Hydrogen Sulfide	174-177	cystathionine beta-synthase	Homo sapiens	160-163
27365395-4	2016	Under endoplasmic reticulum stress conditions, induction of CSE and up-regulation of the CBS inhibitor, CO, a product of heme oxygenase-1, flip the operating preference of CSE from cystathionine to cysteine, transiently stimulating H2S production.	Cystathionine	181-194	cystathionine beta-synthase	Homo sapiens	89-92
27365395-4	2016	Under endoplasmic reticulum stress conditions, induction of CSE and up-regulation of the CBS inhibitor, CO, a product of heme oxygenase-1, flip the operating preference of CSE from cystathionine to cysteine, transiently stimulating H2S production.	Cysteine	198-206	cystathionine beta-synthase	Homo sapiens	89-92
27365395-4	2016	Under endoplasmic reticulum stress conditions, induction of CSE and up-regulation of the CBS inhibitor, CO, a product of heme oxygenase-1, flip the operating preference of CSE from cystathionine to cysteine, transiently stimulating H2S production.	Hydrogen Sulfide	232-235	cystathionine beta-synthase	Homo sapiens	89-92
27365395-6	2016	This metabolite switch from cystathionine to cysteine and/or homocysteine renders H2S synthesis by CSE responsive to the known modulators of CBS: S-adenosylmethionine, NO, and CO. Used acutely, it regulates H2S synthesis; used chronically, it might contribute to disease pathology.	Cystathionine	28-41	cystathionine beta-synthase	Homo sapiens	141-144
27365395-6	2016	This metabolite switch from cystathionine to cysteine and/or homocysteine renders H2S synthesis by CSE responsive to the known modulators of CBS: S-adenosylmethionine, NO, and CO. Used acutely, it regulates H2S synthesis; used chronically, it might contribute to disease pathology.	Cysteine	45-53	cystathionine beta-synthase	Homo sapiens	141-144
27365395-6	2016	This metabolite switch from cystathionine to cysteine and/or homocysteine renders H2S synthesis by CSE responsive to the known modulators of CBS: S-adenosylmethionine, NO, and CO. Used acutely, it regulates H2S synthesis; used chronically, it might contribute to disease pathology.	Homocysteine	61-73	cystathionine beta-synthase	Homo sapiens	141-144
27365395-6	2016	This metabolite switch from cystathionine to cysteine and/or homocysteine renders H2S synthesis by CSE responsive to the known modulators of CBS: S-adenosylmethionine, NO, and CO. Used acutely, it regulates H2S synthesis; used chronically, it might contribute to disease pathology.	Hydrogen Sulfide	82-85	cystathionine beta-synthase	Homo sapiens	141-144
27365395-6	2016	This metabolite switch from cystathionine to cysteine and/or homocysteine renders H2S synthesis by CSE responsive to the known modulators of CBS: S-adenosylmethionine, NO, and CO. Used acutely, it regulates H2S synthesis; used chronically, it might contribute to disease pathology.	Sulfur	84-85	cystathionine beta-synthase	Homo sapiens	141-144
27385096-0	2016	5-FU targets rpL3 to induce mitochondrial apoptosis via cystathionine-beta-synthase in colon cancer cells lacking p53.	Fluorouracil	0-4	cystathionine beta-synthase	Homo sapiens	56-83
27385096-7	2016	It is noteworthy that silencing of CBS is associated to a strong increase of 5-FU-mediated inhibition of cell migration and proliferation.	Fluorouracil	77-81	cystathionine beta-synthase	Homo sapiens	35-38
26765812-2	2016	Regulation of TS pathway kinetics involves stimulation of cystathionine beta-synthase (CBS) by S-adenosylmethionine (SAM) and oxidants such as H2O2, and by Michaelis-Menten principles whereby substrate concentrations affect reaction rates.	S-Adenosylmethionine	95-115	cystathionine beta-synthase	Homo sapiens	58-85
26765812-2	2016	Regulation of TS pathway kinetics involves stimulation of cystathionine beta-synthase (CBS) by S-adenosylmethionine (SAM) and oxidants such as H2O2, and by Michaelis-Menten principles whereby substrate concentrations affect reaction rates.	Hydrogen Peroxide	143-147	cystathionine beta-synthase	Homo sapiens	58-85
26791043-1	2016	Two enzymes in the transsulfuration pathway of homocysteine -cystathionine beta-synthase (CBS) and gamma-cystathionase (CTH)-use cysteine and/or homocysteine to produce the important signaling molecule hydrogen sulfide (H2S) and simultaneously the thioethers lanthionine, cystathionine or homolanthionine.	Cysteine	51-59	cystathionine beta-synthase	Homo sapiens	61-88
26791043-1	2016	Two enzymes in the transsulfuration pathway of homocysteine -cystathionine beta-synthase (CBS) and gamma-cystathionase (CTH)-use cysteine and/or homocysteine to produce the important signaling molecule hydrogen sulfide (H2S) and simultaneously the thioethers lanthionine, cystathionine or homolanthionine.	Cysteine	51-59	cystathionine beta-synthase	Homo sapiens	90-93
26791043-1	2016	Two enzymes in the transsulfuration pathway of homocysteine -cystathionine beta-synthase (CBS) and gamma-cystathionase (CTH)-use cysteine and/or homocysteine to produce the important signaling molecule hydrogen sulfide (H2S) and simultaneously the thioethers lanthionine, cystathionine or homolanthionine.	Homocysteine	47-59	cystathionine beta-synthase	Homo sapiens	61-88
26791043-1	2016	Two enzymes in the transsulfuration pathway of homocysteine -cystathionine beta-synthase (CBS) and gamma-cystathionase (CTH)-use cysteine and/or homocysteine to produce the important signaling molecule hydrogen sulfide (H2S) and simultaneously the thioethers lanthionine, cystathionine or homolanthionine.	Homocysteine	47-59	cystathionine beta-synthase	Homo sapiens	90-93
26791043-1	2016	Two enzymes in the transsulfuration pathway of homocysteine -cystathionine beta-synthase (CBS) and gamma-cystathionase (CTH)-use cysteine and/or homocysteine to produce the important signaling molecule hydrogen sulfide (H2S) and simultaneously the thioethers lanthionine, cystathionine or homolanthionine.	Hydrogen Sulfide	202-218	cystathionine beta-synthase	Homo sapiens	61-88
26791043-1	2016	Two enzymes in the transsulfuration pathway of homocysteine -cystathionine beta-synthase (CBS) and gamma-cystathionase (CTH)-use cysteine and/or homocysteine to produce the important signaling molecule hydrogen sulfide (H2S) and simultaneously the thioethers lanthionine, cystathionine or homolanthionine.	Hydrogen Sulfide	202-218	cystathionine beta-synthase	Homo sapiens	90-93
26791043-1	2016	Two enzymes in the transsulfuration pathway of homocysteine -cystathionine beta-synthase (CBS) and gamma-cystathionase (CTH)-use cysteine and/or homocysteine to produce the important signaling molecule hydrogen sulfide (H2S) and simultaneously the thioethers lanthionine, cystathionine or homolanthionine.	Hydrogen Sulfide	220-223	cystathionine beta-synthase	Homo sapiens	61-88
26791043-1	2016	Two enzymes in the transsulfuration pathway of homocysteine -cystathionine beta-synthase (CBS) and gamma-cystathionase (CTH)-use cysteine and/or homocysteine to produce the important signaling molecule hydrogen sulfide (H2S) and simultaneously the thioethers lanthionine, cystathionine or homolanthionine.	Hydrogen Sulfide	220-223	cystathionine beta-synthase	Homo sapiens	90-93
26791043-1	2016	Two enzymes in the transsulfuration pathway of homocysteine -cystathionine beta-synthase (CBS) and gamma-cystathionase (CTH)-use cysteine and/or homocysteine to produce the important signaling molecule hydrogen sulfide (H2S) and simultaneously the thioethers lanthionine, cystathionine or homolanthionine.	thioethers lanthionine	248-270	cystathionine beta-synthase	Homo sapiens	61-88
26791043-1	2016	Two enzymes in the transsulfuration pathway of homocysteine -cystathionine beta-synthase (CBS) and gamma-cystathionase (CTH)-use cysteine and/or homocysteine to produce the important signaling molecule hydrogen sulfide (H2S) and simultaneously the thioethers lanthionine, cystathionine or homolanthionine.	thioethers lanthionine	248-270	cystathionine beta-synthase	Homo sapiens	90-93
27129884-2	2016	Among uremic toxins, homocysteine and cysteine are both substrates of cystathionine beta-synthase and cystathionine gamma-lyase in hydrogen sulfide biosynthesis, leading to the formation of two sulfur metabolites, lanthionine and homolanthionine, considered stable indirect biomarkers of its production.	Cysteine	25-33	cystathionine beta-synthase	Homo sapiens	70-97
26805382-3	2016	CBS contains two sets of binding sites for S-adenosylmethionine (SAM) that independently regulate the enzyme activity and kinetically stabilize its regulatory domain.	S-Adenosylmethionine	43-63	cystathionine beta-synthase	Homo sapiens	0-3
26805382-3	2016	CBS contains two sets of binding sites for S-adenosylmethionine (SAM) that independently regulate the enzyme activity and kinetically stabilize its regulatory domain.	S-Adenosylmethionine	65-68	cystathionine beta-synthase	Homo sapiens	0-3
27129884-2	2016	Among uremic toxins, homocysteine and cysteine are both substrates of cystathionine beta-synthase and cystathionine gamma-lyase in hydrogen sulfide biosynthesis, leading to the formation of two sulfur metabolites, lanthionine and homolanthionine, considered stable indirect biomarkers of its production.	Hydrogen Sulfide	131-147	cystathionine beta-synthase	Homo sapiens	70-97
27129884-2	2016	Among uremic toxins, homocysteine and cysteine are both substrates of cystathionine beta-synthase and cystathionine gamma-lyase in hydrogen sulfide biosynthesis, leading to the formation of two sulfur metabolites, lanthionine and homolanthionine, considered stable indirect biomarkers of its production.	Sulfur	194-200	cystathionine beta-synthase	Homo sapiens	70-97
26805382-6	2016	Binding of S-adenosylhomocysteine and sinefungin lead to stabilization of the regulatory domains without activation of CBS.	S-Adenosylhomocysteine	11-33	cystathionine beta-synthase	Homo sapiens	119-122
27129884-2	2016	Among uremic toxins, homocysteine and cysteine are both substrates of cystathionine beta-synthase and cystathionine gamma-lyase in hydrogen sulfide biosynthesis, leading to the formation of two sulfur metabolites, lanthionine and homolanthionine, considered stable indirect biomarkers of its production.	lanthionine	214-225	cystathionine beta-synthase	Homo sapiens	70-97
27129884-2	2016	Among uremic toxins, homocysteine and cysteine are both substrates of cystathionine beta-synthase and cystathionine gamma-lyase in hydrogen sulfide biosynthesis, leading to the formation of two sulfur metabolites, lanthionine and homolanthionine, considered stable indirect biomarkers of its production.	L-Homolanthionine	230-245	cystathionine beta-synthase	Homo sapiens	70-97
26805382-6	2016	Binding of S-adenosylhomocysteine and sinefungin lead to stabilization of the regulatory domains without activation of CBS.	sinefungin	38-48	cystathionine beta-synthase	Homo sapiens	119-122
27059523-1	2016	Homocystinuria is a disorder of sulfur metabolism pathway caused by deficiency of cystathionine beta-synthase (CBS).	Sulfur	32-38	cystathionine beta-synthase	Homo sapiens	82-109
27059523-1	2016	Homocystinuria is a disorder of sulfur metabolism pathway caused by deficiency of cystathionine beta-synthase (CBS).	Sulfur	32-38	cystathionine beta-synthase	Homo sapiens	111-114
28806886-0	2016	Rs6586282 of the CBS Gene: Its Lack of Eff ect on Homocysteine Concentrations, and Interaction Eff ects on Body Weight in Elderly Women.	Homocysteine	50-62	cystathionine beta-synthase	Homo sapiens	17-20
27107369-9	2016	Lastly, we found DATS could increase the expressions of cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS), the major H2S-producing enzymes.	diallyl trisulfide	17-21	cystathionine beta-synthase	Homo sapiens	92-119
27107369-9	2016	Lastly, we found DATS could increase the expressions of cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS), the major H2S-producing enzymes.	Hydrogen Sulfide	137-140	cystathionine beta-synthase	Homo sapiens	92-119
26880412-9	2016	RESULTS: Hydroxylamine administration led to a significant decrease in erythropoietin, HIF-1alpha, HIF-2alpha and CBS protein levels during hypoxia.	Hydroxylamine	9-22	cystathionine beta-synthase	Homo sapiens	114-117
26880412-10	2016	This was rescued by administration of GYY 4137 for erythropoietin, CBS and HIF-2alpha.	Naspm	38-41	cystathionine beta-synthase	Homo sapiens	67-70
26508567-2	2016	Cystathionine beta-synthase (CBS)-dependent homocysteine (Hcy) pathway was demonstrated to affect disease severity and mortality in patients with severe sepsis/septic shock.	Homocysteine	44-56	cystathionine beta-synthase	Homo sapiens	0-27
26508567-2	2016	Cystathionine beta-synthase (CBS)-dependent homocysteine (Hcy) pathway was demonstrated to affect disease severity and mortality in patients with severe sepsis/septic shock.	Homocysteine	44-56	cystathionine beta-synthase	Homo sapiens	29-32
26508567-2	2016	Cystathionine beta-synthase (CBS)-dependent homocysteine (Hcy) pathway was demonstrated to affect disease severity and mortality in patients with severe sepsis/septic shock.	Homocysteine	58-61	cystathionine beta-synthase	Homo sapiens	0-27
26508567-2	2016	Cystathionine beta-synthase (CBS)-dependent homocysteine (Hcy) pathway was demonstrated to affect disease severity and mortality in patients with severe sepsis/septic shock.	Homocysteine	58-61	cystathionine beta-synthase	Homo sapiens	29-32
28806886-1	2016	The aim of the present study is to evaluate the effect of the rs6586282 polymorphism of the cystathionine-beta-synthase (CBS) gene, and of the intake of B vitamins on anthropometric parameters, tHcy levels, and lipoprotein levels in women over 60 years of age.	thcy	194-198	cystathionine beta-synthase	Homo sapiens	121-124
28806886-6	2016	The CBS SNP at rs6586282 may infl uence anthropometric parameters, though only in case of low folate intake.	Folic Acid	94-100	cystathionine beta-synthase	Homo sapiens	4-7
27083071-1	2016	Hydrogen sulfide (H2S) is produced in the mammalian body through the enzymatic activities of cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	93-120
27086654-0	2016	A convenient enantioselective CBS-reduction of arylketones in flow-microreactor systems.	arylketones	47-58	cystathionine beta-synthase	Homo sapiens	30-33
27086654-1	2016	A convenient, versatile, and green CBS-asymmetric reduction of aryl and heteroaryl ketones has been developed by using the microreactor technology.	Ketones	83-90	cystathionine beta-synthase	Homo sapiens	35-38
26890936-1	2016	BACKGROUND AND PURPOSE: Hydrogen sulfide (H2S) is a gasotransmitter produced from L-cysteine through the enzymatic action of cystathionine-gamma-lyase (CSE) and/or cystathionine-beta-synthase.	Hydrogen Sulfide	24-40	cystathionine beta-synthase	Homo sapiens	164-191
26890936-1	2016	BACKGROUND AND PURPOSE: Hydrogen sulfide (H2S) is a gasotransmitter produced from L-cysteine through the enzymatic action of cystathionine-gamma-lyase (CSE) and/or cystathionine-beta-synthase.	Hydrogen Sulfide	42-45	cystathionine beta-synthase	Homo sapiens	164-191
26890936-1	2016	BACKGROUND AND PURPOSE: Hydrogen sulfide (H2S) is a gasotransmitter produced from L-cysteine through the enzymatic action of cystathionine-gamma-lyase (CSE) and/or cystathionine-beta-synthase.	Cysteine	82-92	cystathionine beta-synthase	Homo sapiens	164-191
26614970-6	2016	Moreover, in vitro treatment with 17beta-estradiol upregulates the expression of CBS and CSE in human BM stromal cells (hSCs), whereas an H2 S-releasing drug induces osteogenic differentiation of hSCs.	Estradiol	34-50	cystathionine beta-synthase	Homo sapiens	81-84
26518313-0	2016	Tyrosol Attenuates High Fat Diet-Induced Hepatic Oxidative Stress: Potential Involvement of Cystathionine beta-Synthase and Cystathionine gamma-Lyase.	4-hydroxyphenylethanol	0-7	cystathionine beta-synthase	Homo sapiens	92-119
26518313-5	2016	Cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) are major enzymes responsible for endogenous H2S synthesis.	Hydrogen Sulfide	115-118	cystathionine beta-synthase	Homo sapiens	0-27
26518313-5	2016	Cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) are major enzymes responsible for endogenous H2S synthesis.	Hydrogen Sulfide	115-118	cystathionine beta-synthase	Homo sapiens	29-32
26518313-12	2016	These results suggest that the antioxidant properties of tyrosol may be mediated through functional changes in CBS and CSE activity, which might contribute to the hepatoprotective effect of the Mediterranean diet.	4-hydroxyphenylethanol	57-64	cystathionine beta-synthase	Homo sapiens	111-114
27083071-1	2016	Hydrogen sulfide (H2S) is produced in the mammalian body through the enzymatic activities of cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST).	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	122-125
27083071-1	2016	Hydrogen sulfide (H2S) is produced in the mammalian body through the enzymatic activities of cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	122-125
27083071-1	2016	Hydrogen sulfide (H2S) is produced in the mammalian body through the enzymatic activities of cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST).	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	93-120
26867575-1	2016	Cystathionine beta-synthase (CBS) is a pyridoxal phosphate-dependent enzyme that catalyzes the condensation of homocysteine with serine or with cysteine to form cystathionine and either water or hydrogen sulfide, respectively.	Cysteine	115-123	cystathionine beta-synthase	Homo sapiens	0-27
27163055-7	2016	It is demonstrated that the most potent "zipped" inhibitor 6S reduces H2S production in SH-SY5Y cells overexpressing CBS, thereby reducing cell death.	Hydrogen Sulfide	70-73	cystathionine beta-synthase	Homo sapiens	117-120
27000247-6	2016	In addition, NaHS-induced hyperalgesia was partly, but significantly, attenuated by intrathecal injection of hydroxylamine, a cystathionine-beta-synthase (CBS) inhibitor.	sodium bisulfide	13-17	cystathionine beta-synthase	Homo sapiens	126-153
27000247-6	2016	In addition, NaHS-induced hyperalgesia was partly, but significantly, attenuated by intrathecal injection of hydroxylamine, a cystathionine-beta-synthase (CBS) inhibitor.	Hydroxylamine	109-122	cystathionine beta-synthase	Homo sapiens	126-153
26867575-1	2016	Cystathionine beta-synthase (CBS) is a pyridoxal phosphate-dependent enzyme that catalyzes the condensation of homocysteine with serine or with cysteine to form cystathionine and either water or hydrogen sulfide, respectively.	Cystathionine	161-174	cystathionine beta-synthase	Homo sapiens	0-27
26867575-0	2016	Kinetics of Nitrite Reduction and Peroxynitrite Formation by Ferrous Heme in Human Cystathionine beta-Synthase.	Nitrites	12-19	cystathionine beta-synthase	Homo sapiens	83-110
26867575-1	2016	Cystathionine beta-synthase (CBS) is a pyridoxal phosphate-dependent enzyme that catalyzes the condensation of homocysteine with serine or with cysteine to form cystathionine and either water or hydrogen sulfide, respectively.	Water	186-191	cystathionine beta-synthase	Homo sapiens	0-27
26867575-1	2016	Cystathionine beta-synthase (CBS) is a pyridoxal phosphate-dependent enzyme that catalyzes the condensation of homocysteine with serine or with cysteine to form cystathionine and either water or hydrogen sulfide, respectively.	Hydrogen Sulfide	195-211	cystathionine beta-synthase	Homo sapiens	0-27
26867575-0	2016	Kinetics of Nitrite Reduction and Peroxynitrite Formation by Ferrous Heme in Human Cystathionine beta-Synthase.	Peroxynitrous Acid	34-47	cystathionine beta-synthase	Homo sapiens	83-110
26867575-0	2016	Kinetics of Nitrite Reduction and Peroxynitrite Formation by Ferrous Heme in Human Cystathionine beta-Synthase.	ferrous heme	61-73	cystathionine beta-synthase	Homo sapiens	83-110
26847849-6	2016	The expression levels/activities of CBS, CSE, and MPST of specimens and cell lines were analyzed by image semiquantity assay, western blot, and a sulfur-sensitive electrode.	Sulfur	146-152	cystathionine beta-synthase	Homo sapiens	36-39
26867575-1	2016	Cystathionine beta-synthase (CBS) is a pyridoxal phosphate-dependent enzyme that catalyzes the condensation of homocysteine with serine or with cysteine to form cystathionine and either water or hydrogen sulfide, respectively.	Pyridoxal Phosphate	39-58	cystathionine beta-synthase	Homo sapiens	0-27
26867575-1	2016	Cystathionine beta-synthase (CBS) is a pyridoxal phosphate-dependent enzyme that catalyzes the condensation of homocysteine with serine or with cysteine to form cystathionine and either water or hydrogen sulfide, respectively.	Homocysteine	111-123	cystathionine beta-synthase	Homo sapiens	0-27
26867575-1	2016	Cystathionine beta-synthase (CBS) is a pyridoxal phosphate-dependent enzyme that catalyzes the condensation of homocysteine with serine or with cysteine to form cystathionine and either water or hydrogen sulfide, respectively.	Serine	129-135	cystathionine beta-synthase	Homo sapiens	0-27
26992682-8	2016	Transfection of CBS and CSE siRNA reversed the stimulatory effect of l-cysteine on VEGF production in placental cells.	Cysteine	69-79	cystathionine beta-synthase	Homo sapiens	16-19
26750749-4	2016	This study investigated the prevalence of CBS mutations and the common methylenetetrahydrofolate reductase (MTHFR) c.677C&gt;T polymorphism in patients with tHcy &gt;= 50 muM and the association with clinical manifestations.	thcy	157-161	cystathionine beta-synthase	Homo sapiens	42-45
26992682-12	2016	CONCLUSION: H2S produced via CSE and CBS plays a critical role in VEGF production in human placenta.	Hydrogen Sulfide	12-15	cystathionine beta-synthase	Homo sapiens	37-40
26667407-6	2016	Our detailed kinetic analyses demonstrate a robust capacity for Cys-SSH production by the human transsulfuration pathway enzymes, cystathionine beta-synthase and gamma-cystathionase (CSE) and for homocysteine persulfide synthesis from homocystine by CSE only.	Cysteine	64-67	cystathionine beta-synthase	Homo sapiens	130-157
26599618-1	2016	Cystathionine beta synthase (CBS) is a key enzyme in the methionine and cysteine metabolic pathway, acting as a metabolic gatekeeper to regulate the flow of fixed sulfur from methionine to cysteine.	Methionine	57-67	cystathionine beta-synthase	Homo sapiens	29-32
26599618-1	2016	Cystathionine beta synthase (CBS) is a key enzyme in the methionine and cysteine metabolic pathway, acting as a metabolic gatekeeper to regulate the flow of fixed sulfur from methionine to cysteine.	Methionine	175-185	cystathionine beta-synthase	Homo sapiens	29-32
26710076-0	2016	Correction to Kinetics of Reversible Reductive Carbonylation of Heme in Human Cystathionine beta-Synthase.	Heme	64-68	cystathionine beta-synthase	Homo sapiens	78-105
26582199-0	2016	S-Adenosyl-l-methionine Modulates CO and NO  Binding to the Human H2S-generating Enzyme Cystathionine beta-Synthase.	S-Adenosylmethionine	0-23	cystathionine beta-synthase	Homo sapiens	88-115
26582199-0	2016	S-Adenosyl-l-methionine Modulates CO and NO  Binding to the Human H2S-generating Enzyme Cystathionine beta-Synthase.	Hydrogen Sulfide	66-69	cystathionine beta-synthase	Homo sapiens	88-115
26582199-1	2016	Cystathionine beta-synthase (CBS) is a key enzyme in human (patho)physiology with a central role in hydrogen sulfide metabolism.	Hydrogen Sulfide	100-116	cystathionine beta-synthase	Homo sapiens	0-27
26582199-1	2016	Cystathionine beta-synthase (CBS) is a key enzyme in human (patho)physiology with a central role in hydrogen sulfide metabolism.	Hydrogen Sulfide	100-116	cystathionine beta-synthase	Homo sapiens	29-32
26582199-10	2016	These unprecedented observations demonstrate that CBS activation by AdoMet puzzlingly sensitizes the enzyme toward inhibition by exogenous ligands, like CO and NO( ).	Carbon Monoxide	153-155	cystathionine beta-synthase	Homo sapiens	50-53
26599618-1	2016	Cystathionine beta synthase (CBS) is a key enzyme in the methionine and cysteine metabolic pathway, acting as a metabolic gatekeeper to regulate the flow of fixed sulfur from methionine to cysteine.	Cysteine	72-80	cystathionine beta-synthase	Homo sapiens	29-32
26599618-1	2016	Cystathionine beta synthase (CBS) is a key enzyme in the methionine and cysteine metabolic pathway, acting as a metabolic gatekeeper to regulate the flow of fixed sulfur from methionine to cysteine.	Sulfur	163-169	cystathionine beta-synthase	Homo sapiens	29-32
26599618-1	2016	Cystathionine beta synthase (CBS) is a key enzyme in the methionine and cysteine metabolic pathway, acting as a metabolic gatekeeper to regulate the flow of fixed sulfur from methionine to cysteine.	Cysteine	189-197	cystathionine beta-synthase	Homo sapiens	29-32
27150157-1	2016	Hydrogen sulfide (H2S), the third gasotransmitter, is endogenously generated by certain H2S synthesizing enzymes, including cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) from L-cysteine in the mammalian body.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	160-187
27150157-1	2016	Hydrogen sulfide (H2S), the third gasotransmitter, is endogenously generated by certain H2S synthesizing enzymes, including cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) from L-cysteine in the mammalian body.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	160-187
27150157-1	2016	Hydrogen sulfide (H2S), the third gasotransmitter, is endogenously generated by certain H2S synthesizing enzymes, including cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) from L-cysteine in the mammalian body.	Hydrogen Sulfide	88-91	cystathionine beta-synthase	Homo sapiens	160-187
27150157-1	2016	Hydrogen sulfide (H2S), the third gasotransmitter, is endogenously generated by certain H2S synthesizing enzymes, including cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) from L-cysteine in the mammalian body.	Cysteine	199-209	cystathionine beta-synthase	Homo sapiens	160-187
26931358-2	2016	HCU is caused by a deficiency in enzymatic degradation of homocysteine, a toxic intermediate of methionine transformation to cysteine, chiefly due to missense mutations in the cystathionine betasynthase (CBS) gene.	Methionine	96-106	cystathionine beta-synthase	Homo sapiens	176-202
26460077-0	2016	Cystathionine beta-synthase-derived hydrogen sulfide is involved in human malignant hyperthermia.	Hydrogen Sulfide	36-52	cystathionine beta-synthase	Homo sapiens	0-27
26931358-2	2016	HCU is caused by a deficiency in enzymatic degradation of homocysteine, a toxic intermediate of methionine transformation to cysteine, chiefly due to missense mutations in the cystathionine betasynthase (CBS) gene.	Methionine	96-106	cystathionine beta-synthase	Homo sapiens	204-207
26931358-2	2016	HCU is caused by a deficiency in enzymatic degradation of homocysteine, a toxic intermediate of methionine transformation to cysteine, chiefly due to missense mutations in the cystathionine betasynthase (CBS) gene.	Cysteine	62-70	cystathionine beta-synthase	Homo sapiens	176-202
26931358-2	2016	HCU is caused by a deficiency in enzymatic degradation of homocysteine, a toxic intermediate of methionine transformation to cysteine, chiefly due to missense mutations in the cystathionine betasynthase (CBS) gene.	Cysteine	62-70	cystathionine beta-synthase	Homo sapiens	204-207
26931358-5	2016	In this review, we summarize the complex nature of CBS, its multidomain architecture, the interplay between the three cofactors required for CBS function (heme, pyridoxal-5"-phosphate (PLP) and S-adenosyl-L-methionine) as well as the intricate allosteric regulatory mechanism only recently explained thanks to advances in CBS crystallography.	Heme	155-159	cystathionine beta-synthase	Homo sapiens	51-54
26931358-5	2016	In this review, we summarize the complex nature of CBS, its multidomain architecture, the interplay between the three cofactors required for CBS function (heme, pyridoxal-5"-phosphate (PLP) and S-adenosyl-L-methionine) as well as the intricate allosteric regulatory mechanism only recently explained thanks to advances in CBS crystallography.	Heme	155-159	cystathionine beta-synthase	Homo sapiens	141-144
26931358-5	2016	In this review, we summarize the complex nature of CBS, its multidomain architecture, the interplay between the three cofactors required for CBS function (heme, pyridoxal-5"-phosphate (PLP) and S-adenosyl-L-methionine) as well as the intricate allosteric regulatory mechanism only recently explained thanks to advances in CBS crystallography.	Heme	155-159	cystathionine beta-synthase	Homo sapiens	141-144
26931358-5	2016	In this review, we summarize the complex nature of CBS, its multidomain architecture, the interplay between the three cofactors required for CBS function (heme, pyridoxal-5"-phosphate (PLP) and S-adenosyl-L-methionine) as well as the intricate allosteric regulatory mechanism only recently explained thanks to advances in CBS crystallography.	S-Adenosylmethionine	194-217	cystathionine beta-synthase	Homo sapiens	51-54
27019751-2	2016	H2S can be generated endogenously from L-cysteine by multiple enzymes, including cystathionine gamma-lyase, cystathionine beta-synthase, and 3-mercaptopyruvate sulfurtransferase in combination with cysteine aminotransferase.	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	108-135
27057284-7	2016	In vitro, NaHS treatment protected cardiomyocytes from hypoxic injury and raised CBS levels in a concentration-dependent manner.	sodium bisulfide	10-14	cystathionine beta-synthase	Homo sapiens	81-84
27057284-9	2016	NaHS treatment increased the activity of CSE/CBS but not of 3-MST.	sodium bisulfide	0-4	cystathionine beta-synthase	Homo sapiens	45-48
26405298-3	2016	Here, we show that the loss of CBS function in endothelial cells (ECs) leads to a significant down-regulation of cellular hydrogen sulfide (H2S) by 50% and of glutathione (GSH) by 40%.	Hydrogen Sulfide	122-138	cystathionine beta-synthase	Homo sapiens	31-34
26405298-3	2016	Here, we show that the loss of CBS function in endothelial cells (ECs) leads to a significant down-regulation of cellular hydrogen sulfide (H2S) by 50% and of glutathione (GSH) by 40%.	Hydrogen Sulfide	140-143	cystathionine beta-synthase	Homo sapiens	31-34
26405298-3	2016	Here, we show that the loss of CBS function in endothelial cells (ECs) leads to a significant down-regulation of cellular hydrogen sulfide (H2S) by 50% and of glutathione (GSH) by 40%.	Glutathione	159-170	cystathionine beta-synthase	Homo sapiens	31-34
26405298-3	2016	Here, we show that the loss of CBS function in endothelial cells (ECs) leads to a significant down-regulation of cellular hydrogen sulfide (H2S) by 50% and of glutathione (GSH) by 40%.	Glutathione	172-175	cystathionine beta-synthase	Homo sapiens	31-34
26405298-6	2016	Reinstating H2S but not GSH in CBS-silenced ECs restored Sp1 levels and its binding to the VEGFR-2 promoter and VEGFR-2, NRP-1 expression, VEGF-dependent proliferation, and migration phenotypes.	Hydrogen Sulfide	12-15	cystathionine beta-synthase	Homo sapiens	31-34
26519441-5	2016	Targeted analyses demonstrated significant associations of homocysteine and variants within the CBS (Cystathionine beta-Synthase) gene.	Homocysteine	59-71	cystathionine beta-synthase	Homo sapiens	96-99
26519441-5	2016	Targeted analyses demonstrated significant associations of homocysteine and variants within the CBS (Cystathionine beta-Synthase) gene.	Homocysteine	59-71	cystathionine beta-synthase	Homo sapiens	101-128
26955774-3	2016	Cystathionine-beta-synthase (CBS) is a key-enzyme in the pathway, converting homocysteine into cysteine via cystathionine.	Homocysteine	77-89	cystathionine beta-synthase	Homo sapiens	0-27
26955774-3	2016	Cystathionine-beta-synthase (CBS) is a key-enzyme in the pathway, converting homocysteine into cysteine via cystathionine.	Homocysteine	77-89	cystathionine beta-synthase	Homo sapiens	29-32
26955774-3	2016	Cystathionine-beta-synthase (CBS) is a key-enzyme in the pathway, converting homocysteine into cysteine via cystathionine.	Cysteine	81-89	cystathionine beta-synthase	Homo sapiens	0-27
26955774-3	2016	Cystathionine-beta-synthase (CBS) is a key-enzyme in the pathway, converting homocysteine into cysteine via cystathionine.	Cysteine	81-89	cystathionine beta-synthase	Homo sapiens	29-32
26955774-3	2016	Cystathionine-beta-synthase (CBS) is a key-enzyme in the pathway, converting homocysteine into cysteine via cystathionine.	Cystathionine	108-121	cystathionine beta-synthase	Homo sapiens	0-27
26955774-3	2016	Cystathionine-beta-synthase (CBS) is a key-enzyme in the pathway, converting homocysteine into cysteine via cystathionine.	Cystathionine	108-121	cystathionine beta-synthase	Homo sapiens	29-32
26955774-4	2016	Another product of CBS is hydrogen sulfide (H2S), a vasodilatory, proangiogenic and cytoprotective gas that is thought to play a role in placental and vascular function during pregnancy.	Hydrogen Sulfide	26-42	cystathionine beta-synthase	Homo sapiens	19-22
26955774-4	2016	Another product of CBS is hydrogen sulfide (H2S), a vasodilatory, proangiogenic and cytoprotective gas that is thought to play a role in placental and vascular function during pregnancy.	Hydrogen Sulfide	44-47	cystathionine beta-synthase	Homo sapiens	19-22
26955774-13	2016	Decreased cysteine concentrations in normotensive pregnant women carrying the minor allele of rs11203172, may be due to increased cysteine conversion to H2S by CBS.	Cysteine	10-18	cystathionine beta-synthase	Homo sapiens	160-163
26955774-13	2016	Decreased cysteine concentrations in normotensive pregnant women carrying the minor allele of rs11203172, may be due to increased cysteine conversion to H2S by CBS.	Cysteine	130-138	cystathionine beta-synthase	Homo sapiens	160-163
26955774-13	2016	Decreased cysteine concentrations in normotensive pregnant women carrying the minor allele of rs11203172, may be due to increased cysteine conversion to H2S by CBS.	Hydrogen Sulfide	153-156	cystathionine beta-synthase	Homo sapiens	160-163
27019751-2	2016	H2S can be generated endogenously from L-cysteine by multiple enzymes, including cystathionine gamma-lyase, cystathionine beta-synthase, and 3-mercaptopyruvate sulfurtransferase in combination with cysteine aminotransferase.	Cysteine	39-49	cystathionine beta-synthase	Homo sapiens	108-135
26639091-1	2015	Cystathionine beta-synthase (CBS) deficiency, well known as classical homocystinuria, is a rare autosomal recessive inborn error of homocysteine and sulfur metabolism.	Sulfur	149-155	cystathionine beta-synthase	Homo sapiens	0-27
26464485-0	2015	Small aminothiol compounds improve the function of Arg to Cys variant proteins: effect on the human cystathionine beta-synthase p.R336C.	Aminothiol	6-16	cystathionine beta-synthase	Homo sapiens	100-127
26464485-0	2015	Small aminothiol compounds improve the function of Arg to Cys variant proteins: effect on the human cystathionine beta-synthase p.R336C.	Arginine	51-54	cystathionine beta-synthase	Homo sapiens	100-127
26464485-0	2015	Small aminothiol compounds improve the function of Arg to Cys variant proteins: effect on the human cystathionine beta-synthase p.R336C.	Cysteine	58-61	cystathionine beta-synthase	Homo sapiens	100-127
26464485-1	2015	The key regulatory point of L-methionine (Met) and L-homocysteine (Hcy) degradation is catalyzed by cystathionine beta-synthase (CBS).	Methionine	28-40	cystathionine beta-synthase	Homo sapiens	100-127
26464485-1	2015	The key regulatory point of L-methionine (Met) and L-homocysteine (Hcy) degradation is catalyzed by cystathionine beta-synthase (CBS).	Methionine	28-40	cystathionine beta-synthase	Homo sapiens	129-132
26464485-1	2015	The key regulatory point of L-methionine (Met) and L-homocysteine (Hcy) degradation is catalyzed by cystathionine beta-synthase (CBS).	Methionine	42-45	cystathionine beta-synthase	Homo sapiens	100-127
26464485-1	2015	The key regulatory point of L-methionine (Met) and L-homocysteine (Hcy) degradation is catalyzed by cystathionine beta-synthase (CBS).	Methionine	42-45	cystathionine beta-synthase	Homo sapiens	129-132
26464485-1	2015	The key regulatory point of L-methionine (Met) and L-homocysteine (Hcy) degradation is catalyzed by cystathionine beta-synthase (CBS).	Homocysteine	51-65	cystathionine beta-synthase	Homo sapiens	100-127
26464485-1	2015	The key regulatory point of L-methionine (Met) and L-homocysteine (Hcy) degradation is catalyzed by cystathionine beta-synthase (CBS).	Homocysteine	51-65	cystathionine beta-synthase	Homo sapiens	129-132
26464485-1	2015	The key regulatory point of L-methionine (Met) and L-homocysteine (Hcy) degradation is catalyzed by cystathionine beta-synthase (CBS).	Homocysteine	67-70	cystathionine beta-synthase	Homo sapiens	100-127
26464485-1	2015	The key regulatory point of L-methionine (Met) and L-homocysteine (Hcy) degradation is catalyzed by cystathionine beta-synthase (CBS).	Homocysteine	67-70	cystathionine beta-synthase	Homo sapiens	129-132
26464485-6	2015	Based on these findings, we aimed to study whether cysteamine was able to improve the function of p.R336C CBS variant.	Cysteamine	51-61	cystathionine beta-synthase	Homo sapiens	106-109
26464485-11	2015	Our results show that cysteamine and MEG are able to specifically improve the function of the CBS p.R336C variant, suggesting that any Arg-to-Cys substitution accessible to these small molecules may be converted back to a moiety resembling Arg.	Cysteamine	22-32	cystathionine beta-synthase	Homo sapiens	94-97
26464485-11	2015	Our results show that cysteamine and MEG are able to specifically improve the function of the CBS p.R336C variant, suggesting that any Arg-to-Cys substitution accessible to these small molecules may be converted back to a moiety resembling Arg.	Arginine	135-138	cystathionine beta-synthase	Homo sapiens	94-97
26464485-11	2015	Our results show that cysteamine and MEG are able to specifically improve the function of the CBS p.R336C variant, suggesting that any Arg-to-Cys substitution accessible to these small molecules may be converted back to a moiety resembling Arg.	Cysteine	142-145	cystathionine beta-synthase	Homo sapiens	94-97
26464485-11	2015	Our results show that cysteamine and MEG are able to specifically improve the function of the CBS p.R336C variant, suggesting that any Arg-to-Cys substitution accessible to these small molecules may be converted back to a moiety resembling Arg.	Arginine	240-243	cystathionine beta-synthase	Homo sapiens	94-97
26453916-1	2015	Hydrogen sulfide (H2S) is produced enzymatically by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), as well as other enzymes in mammalian tissues.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	52-79
26453916-1	2015	Hydrogen sulfide (H2S) is produced enzymatically by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), as well as other enzymes in mammalian tissues.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	52-79
25516282-1	2015	BACKGROUND &amp; AIMS: Many studies have reported that serum total homocysteine (tHcy) levels in cystathionine-beta-synthase (CBS) carriers are usually normal and only elevated after a methionine load.	Adenosine Monophosphate	12-15	cystathionine beta-synthase	Homo sapiens	97-124
25516282-1	2015	BACKGROUND &amp; AIMS: Many studies have reported that serum total homocysteine (tHcy) levels in cystathionine-beta-synthase (CBS) carriers are usually normal and only elevated after a methionine load.	Homocysteine	67-79	cystathionine beta-synthase	Homo sapiens	97-124
25516282-1	2015	BACKGROUND &amp; AIMS: Many studies have reported that serum total homocysteine (tHcy) levels in cystathionine-beta-synthase (CBS) carriers are usually normal and only elevated after a methionine load.	Homocysteine	67-79	cystathionine beta-synthase	Homo sapiens	126-129
25516282-1	2015	BACKGROUND &amp; AIMS: Many studies have reported that serum total homocysteine (tHcy) levels in cystathionine-beta-synthase (CBS) carriers are usually normal and only elevated after a methionine load.	thcy	81-85	cystathionine beta-synthase	Homo sapiens	97-124
25516282-1	2015	BACKGROUND &amp; AIMS: Many studies have reported that serum total homocysteine (tHcy) levels in cystathionine-beta-synthase (CBS) carriers are usually normal and only elevated after a methionine load.	thcy	81-85	cystathionine beta-synthase	Homo sapiens	126-129
25516282-1	2015	BACKGROUND &amp; AIMS: Many studies have reported that serum total homocysteine (tHcy) levels in cystathionine-beta-synthase (CBS) carriers are usually normal and only elevated after a methionine load.	Methionine	185-195	cystathionine beta-synthase	Homo sapiens	97-124
25516282-1	2015	BACKGROUND &amp; AIMS: Many studies have reported that serum total homocysteine (tHcy) levels in cystathionine-beta-synthase (CBS) carriers are usually normal and only elevated after a methionine load.	Methionine	185-195	cystathionine beta-synthase	Homo sapiens	126-129
25516282-6	2015	We evaluated if the CBS carriers tend to have higher fasting serum tHcy concentrations than non-carriers in presence of folate deficiency.	thcy	67-71	cystathionine beta-synthase	Homo sapiens	20-23
25516282-8	2015	RESULTS: The serum tHcy level of the Tao CBS carriers (17.9 +- 3.8 mumol/l) was significantly higher than in Tao non-carriers (15.7 +- 3.5 mumol/l; p &lt; 0.008) and Taiwanese controls (11.8 +- 2.9 mumol/l; p &lt; 0.001).	thcy	19-23	cystathionine beta-synthase	Homo sapiens	41-44
25516282-12	2015	CONCLUSIONS: CBS carriers tend to have a higher tHcy level in the presence of folate deficiency than non-carriers.	thcy	48-52	cystathionine beta-synthase	Homo sapiens	13-16
25516282-14	2015	Owing to a significantly elevated level of fasting tHcy without methionine loading, it is important to evaluate the risk of cardiovascular disease in CBS carriers with folate deficiency.	thcy	51-55	cystathionine beta-synthase	Homo sapiens	150-153
26192364-6	2015	Inhibition of the H2S producing enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), with carboxymethoxylamine (AOA) and L-propargylglycine (PPG) enhanced ET-1 contractions.	propargylglycine	168-171	cystathionine beta-synthase	Homo sapiens	41-68
27682122-6	2015	In the gastrointestinal tract, in addition to H2S production by mammalian cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE), H2S is also generated by the metabolic activity of resident gut microbes, mainly by colonic Sulfate-Reducing Bacteria (SRB) via a dissimilatory sulfate reduction (DSR) pathway.	Hydrogen Sulfide	46-49	cystathionine beta-synthase	Homo sapiens	74-101
27682122-6	2015	In the gastrointestinal tract, in addition to H2S production by mammalian cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE), H2S is also generated by the metabolic activity of resident gut microbes, mainly by colonic Sulfate-Reducing Bacteria (SRB) via a dissimilatory sulfate reduction (DSR) pathway.	Hydrogen Sulfide	142-145	cystathionine beta-synthase	Homo sapiens	74-101
26192364-6	2015	Inhibition of the H2S producing enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), with carboxymethoxylamine (AOA) and L-propargylglycine (PPG) enhanced ET-1 contractions.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	41-68
26307088-9	2015	Notably, DACOR1 induction resulted in down-regulation of Cystathionine beta-synthase, which is known to lead to increased levels of S-adenosyl methionine-the key methyl donor for DNA methylation.	S-Adenosylmethionine	132-153	cystathionine beta-synthase	Homo sapiens	57-84
26192364-6	2015	Inhibition of the H2S producing enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), with carboxymethoxylamine (AOA) and L-propargylglycine (PPG) enhanced ET-1 contractions.	Aminooxyacetic Acid	117-137	cystathionine beta-synthase	Homo sapiens	41-68
26192364-6	2015	Inhibition of the H2S producing enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), with carboxymethoxylamine (AOA) and L-propargylglycine (PPG) enhanced ET-1 contractions.	propargylglycine	148-166	cystathionine beta-synthase	Homo sapiens	41-68
26452259-3	2015	We examined the role of CBS in regulation of triglycerides, cholesterol and lipogenic enzymes via the lipogenic transcription factors SREBP1 and SREBP2.	Triglycerides	45-58	cystathionine beta-synthase	Homo sapiens	24-27
26452259-3	2015	We examined the role of CBS in regulation of triglycerides, cholesterol and lipogenic enzymes via the lipogenic transcription factors SREBP1 and SREBP2.	Cholesterol	60-71	cystathionine beta-synthase	Homo sapiens	24-27
26475388-3	2015	Since CBS 21 repeats allele carriers show a decrease of CBS enzyme activity possibly leading to lower intracellular glutathione concentration, these results could be explained by a higher not disjunction probability of chromosome 21 in oocytes, due to poor antioxidative protection against reactive oxygen species (ROS) toxic activity.	Glutathione	116-127	cystathionine beta-synthase	Homo sapiens	6-9
26269939-5	2015	Immunocytochemical staining, flow cytometry, and Western blot analysis were used to examine the expression of H2S-synthesizing enzymes cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).	Hydrogen Sulfide	110-113	cystathionine beta-synthase	Homo sapiens	135-162
26337042-0	2015	A Dual-Response Fluorescent Probe Reveals the H2 O2 -Induced H2 S Biogenesis through a Cystathionine beta-Synthase Pathway.	Hydrogen Peroxide	46-51	cystathionine beta-synthase	Homo sapiens	87-114
26337042-0	2015	A Dual-Response Fluorescent Probe Reveals the H2 O2 -Induced H2 S Biogenesis through a Cystathionine beta-Synthase Pathway.	Hydrogen Sulfide	61-65	cystathionine beta-synthase	Homo sapiens	87-114
26337042-6	2015	By using gene-knockdown techniques with bioimaging, the H2 S biogenesis was found to be majorly cystathionine beta-synthase (CBS)-dependent.	Hydrogen	56-58	cystathionine beta-synthase	Homo sapiens	96-123
26475388-3	2015	Since CBS 21 repeats allele carriers show a decrease of CBS enzyme activity possibly leading to lower intracellular glutathione concentration, these results could be explained by a higher not disjunction probability of chromosome 21 in oocytes, due to poor antioxidative protection against reactive oxygen species (ROS) toxic activity.	Glutathione	116-127	cystathionine beta-synthase	Homo sapiens	56-59
26475388-3	2015	Since CBS 21 repeats allele carriers show a decrease of CBS enzyme activity possibly leading to lower intracellular glutathione concentration, these results could be explained by a higher not disjunction probability of chromosome 21 in oocytes, due to poor antioxidative protection against reactive oxygen species (ROS) toxic activity.	Reactive Oxygen Species	290-313	cystathionine beta-synthase	Homo sapiens	6-9
26475388-3	2015	Since CBS 21 repeats allele carriers show a decrease of CBS enzyme activity possibly leading to lower intracellular glutathione concentration, these results could be explained by a higher not disjunction probability of chromosome 21 in oocytes, due to poor antioxidative protection against reactive oxygen species (ROS) toxic activity.	Reactive Oxygen Species	290-313	cystathionine beta-synthase	Homo sapiens	56-59
26475388-3	2015	Since CBS 21 repeats allele carriers show a decrease of CBS enzyme activity possibly leading to lower intracellular glutathione concentration, these results could be explained by a higher not disjunction probability of chromosome 21 in oocytes, due to poor antioxidative protection against reactive oxygen species (ROS) toxic activity.	Reactive Oxygen Species	315-318	cystathionine beta-synthase	Homo sapiens	6-9
26475388-3	2015	Since CBS 21 repeats allele carriers show a decrease of CBS enzyme activity possibly leading to lower intracellular glutathione concentration, these results could be explained by a higher not disjunction probability of chromosome 21 in oocytes, due to poor antioxidative protection against reactive oxygen species (ROS) toxic activity.	Reactive Oxygen Species	315-318	cystathionine beta-synthase	Homo sapiens	56-59
26221164-1	2015	Objective Homocystinuria is an inborn error of amino acid metabolism caused by cystathionine beta-synthase deficiency that affects methionine metabolism.	Methionine	131-141	cystathionine beta-synthase	Homo sapiens	79-106
26574261-1	2015	The effect of polar flattening on the stability of 32 halogen-bonded complexes was investigated by utilizing CCSD(T)/CBS, DFT, and DFT-SAPT/CBS methods.	Halogens	54-61	cystathionine beta-synthase	Homo sapiens	117-120
26574261-1	2015	The effect of polar flattening on the stability of 32 halogen-bonded complexes was investigated by utilizing CCSD(T)/CBS, DFT, and DFT-SAPT/CBS methods.	Halogens	54-61	cystathionine beta-synthase	Homo sapiens	140-143
26368121-0	2015	Human Cystathionine-beta-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium.	serine227	53-62	cystathionine beta-synthase	Homo sapiens	6-33
26368121-0	2015	Human Cystathionine-beta-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium.	Hydrogen Sulfide	73-89	cystathionine beta-synthase	Homo sapiens	6-33
26368121-4	2015	Hydrogen sulfide is mainly produced in human bladder by the action of cystathionine-beta-synthase.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	70-97
26368121-5	2015	Here, we demonstrate that human cystathionine-beta-synthase activity is regulated in a cGMP/PKG-dependent manner through phosphorylation at serine 227.	Cyclic GMP	87-91	cystathionine beta-synthase	Homo sapiens	32-59
26368121-5	2015	Here, we demonstrate that human cystathionine-beta-synthase activity is regulated in a cGMP/PKG-dependent manner through phosphorylation at serine 227.	Serine	140-146	cystathionine beta-synthase	Homo sapiens	32-59
26368121-9	2015	Moreover, the silencing of cystathionine-beta-synthase in T24 cells leads to a marked decrease in hydrogen sulfide production either in basal condition or following 8-Br-cGMP challenge.	Hydrogen Sulfide	98-114	cystathionine beta-synthase	Homo sapiens	27-54
26368121-9	2015	Moreover, the silencing of cystathionine-beta-synthase in T24 cells leads to a marked decrease in hydrogen sulfide production either in basal condition or following 8-Br-cGMP challenge.	8-br	165-169	cystathionine beta-synthase	Homo sapiens	27-54
26368121-9	2015	Moreover, the silencing of cystathionine-beta-synthase in T24 cells leads to a marked decrease in hydrogen sulfide production either in basal condition or following 8-Br-cGMP challenge.	Cyclic GMP	170-174	cystathionine beta-synthase	Homo sapiens	27-54
26368121-11	2015	The Ser227Ala mutant cystathionine-beta-synthase shows a notable reduction in basal biosynthesis of hydrogen sulfide becoming unresponsive to the 8-Br-cGMP challenge.	Hydrogen Sulfide	100-116	cystathionine beta-synthase	Homo sapiens	21-48
26368121-11	2015	The Ser227Ala mutant cystathionine-beta-synthase shows a notable reduction in basal biosynthesis of hydrogen sulfide becoming unresponsive to the 8-Br-cGMP challenge.	8-br	146-150	cystathionine beta-synthase	Homo sapiens	21-48
26368121-11	2015	The Ser227Ala mutant cystathionine-beta-synthase shows a notable reduction in basal biosynthesis of hydrogen sulfide becoming unresponsive to the 8-Br-cGMP challenge.	Cyclic GMP	151-155	cystathionine beta-synthase	Homo sapiens	21-48
26051168-1	2015	Cystathionine beta-synthase (CBS) is an enzyme in the transulfuration pathway that can catalyze the condensation of homocysteine (Hcy) and cysteine (Cys) to hydrogen sulfide (H2S) and cystathionine (CTH).	Homocysteine	116-128	cystathionine beta-synthase	Homo sapiens	29-32
26051168-1	2015	Cystathionine beta-synthase (CBS) is an enzyme in the transulfuration pathway that can catalyze the condensation of homocysteine (Hcy) and cysteine (Cys) to hydrogen sulfide (H2S) and cystathionine (CTH).	Homocysteine	130-133	cystathionine beta-synthase	Homo sapiens	0-27
26051168-1	2015	Cystathionine beta-synthase (CBS) is an enzyme in the transulfuration pathway that can catalyze the condensation of homocysteine (Hcy) and cysteine (Cys) to hydrogen sulfide (H2S) and cystathionine (CTH).	Homocysteine	130-133	cystathionine beta-synthase	Homo sapiens	29-32
26051168-1	2015	Cystathionine beta-synthase (CBS) is an enzyme in the transulfuration pathway that can catalyze the condensation of homocysteine (Hcy) and cysteine (Cys) to hydrogen sulfide (H2S) and cystathionine (CTH).	Cysteine	120-128	cystathionine beta-synthase	Homo sapiens	0-27
26051168-1	2015	Cystathionine beta-synthase (CBS) is an enzyme in the transulfuration pathway that can catalyze the condensation of homocysteine (Hcy) and cysteine (Cys) to hydrogen sulfide (H2S) and cystathionine (CTH).	Cysteine	120-128	cystathionine beta-synthase	Homo sapiens	29-32
26051168-1	2015	Cystathionine beta-synthase (CBS) is an enzyme in the transulfuration pathway that can catalyze the condensation of homocysteine (Hcy) and cysteine (Cys) to hydrogen sulfide (H2S) and cystathionine (CTH).	Cysteine	0-3	cystathionine beta-synthase	Homo sapiens	29-32
26051168-1	2015	Cystathionine beta-synthase (CBS) is an enzyme in the transulfuration pathway that can catalyze the condensation of homocysteine (Hcy) and cysteine (Cys) to hydrogen sulfide (H2S) and cystathionine (CTH).	Hydrogen Sulfide	157-173	cystathionine beta-synthase	Homo sapiens	0-27
26051168-1	2015	Cystathionine beta-synthase (CBS) is an enzyme in the transulfuration pathway that can catalyze the condensation of homocysteine (Hcy) and cysteine (Cys) to hydrogen sulfide (H2S) and cystathionine (CTH).	Hydrogen Sulfide	157-173	cystathionine beta-synthase	Homo sapiens	29-32
26051168-1	2015	Cystathionine beta-synthase (CBS) is an enzyme in the transulfuration pathway that can catalyze the condensation of homocysteine (Hcy) and cysteine (Cys) to hydrogen sulfide (H2S) and cystathionine (CTH).	Hydrogen Sulfide	175-178	cystathionine beta-synthase	Homo sapiens	0-27
26051168-1	2015	Cystathionine beta-synthase (CBS) is an enzyme in the transulfuration pathway that can catalyze the condensation of homocysteine (Hcy) and cysteine (Cys) to hydrogen sulfide (H2S) and cystathionine (CTH).	Hydrogen Sulfide	175-178	cystathionine beta-synthase	Homo sapiens	29-32
26051168-1	2015	Cystathionine beta-synthase (CBS) is an enzyme in the transulfuration pathway that can catalyze the condensation of homocysteine (Hcy) and cysteine (Cys) to hydrogen sulfide (H2S) and cystathionine (CTH).	Cystathionine	184-197	cystathionine beta-synthase	Homo sapiens	0-27
26051168-1	2015	Cystathionine beta-synthase (CBS) is an enzyme in the transulfuration pathway that can catalyze the condensation of homocysteine (Hcy) and cysteine (Cys) to hydrogen sulfide (H2S) and cystathionine (CTH).	Cystathionine	184-197	cystathionine beta-synthase	Homo sapiens	29-32
26051168-1	2015	Cystathionine beta-synthase (CBS) is an enzyme in the transulfuration pathway that can catalyze the condensation of homocysteine (Hcy) and cysteine (Cys) to hydrogen sulfide (H2S) and cystathionine (CTH).	Cystathionine	199-202	cystathionine beta-synthase	Homo sapiens	0-27
26051168-1	2015	Cystathionine beta-synthase (CBS) is an enzyme in the transulfuration pathway that can catalyze the condensation of homocysteine (Hcy) and cysteine (Cys) to hydrogen sulfide (H2S) and cystathionine (CTH).	Cystathionine	199-202	cystathionine beta-synthase	Homo sapiens	29-32
26051168-2	2015	CBS-derived H2S is important in angiogenesis and drug resistance in colon and ovarian cancers, respectively.	Hydrogen Sulfide	12-15	cystathionine beta-synthase	Homo sapiens	0-3
26051168-4	2015	This study investigated the mechanistic role of CBS-derived H2S in the protection of human breast cancer (HBC) cells against activated macrophages.	Hydrogen Sulfide	60-63	cystathionine beta-synthase	Homo sapiens	48-51
26051168-7	2015	Silencing of CBS in HBC cells caused a significant decrease in the levels of H2S and CTH but did not affect the growth of these cells per se, in in vitro cultures.	Hydrogen Sulfide	77-80	cystathionine beta-synthase	Homo sapiens	13-16
26051168-7	2015	Silencing of CBS in HBC cells caused a significant decrease in the levels of H2S and CTH but did not affect the growth of these cells per se, in in vitro cultures.	Cystathionine	85-88	cystathionine beta-synthase	Homo sapiens	13-16
26051168-10	2015	Exogenous addition of H2S countered the effects of CBS silencing in the presence of macrophages.	Hydrogen Sulfide	22-25	cystathionine beta-synthase	Homo sapiens	51-54
25873304-2	2015	Cystathionine beta-synthase (CBS) has been implicated as the predominant H2S-producing enzyme in central nervous system.	Hydrogen Sulfide	73-76	cystathionine beta-synthase	Homo sapiens	0-27
25873304-2	2015	Cystathionine beta-synthase (CBS) has been implicated as the predominant H2S-producing enzyme in central nervous system.	Hydrogen Sulfide	73-76	cystathionine beta-synthase	Homo sapiens	29-32
25873304-3	2015	When SH-SY5Y cells were transfected to overexpress CBS, these cells were able to synthesize H2S when exposed to high levels of enzyme substrates but not substrate concentrations that may reflect normal physiological conditions.	Hydrogen Sulfide	92-95	cystathionine beta-synthase	Homo sapiens	51-54
25873304-9	2015	These results imply that in acute ischemic conditions, CBS is upregulated and activated by truncation causing an increased production of H2S, which exacerbate the ischemic injuries.	Hydrogen Sulfide	137-140	cystathionine beta-synthase	Homo sapiens	55-58
26469268-0	2015	Correction: Human Cystathionine-beta-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium.	serine227	65-74	cystathionine beta-synthase	Homo sapiens	18-45
26469268-0	2015	Correction: Human Cystathionine-beta-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium.	Hydrogen Sulfide	85-101	cystathionine beta-synthase	Homo sapiens	18-45
26051168-1	2015	Cystathionine beta-synthase (CBS) is an enzyme in the transulfuration pathway that can catalyze the condensation of homocysteine (Hcy) and cysteine (Cys) to hydrogen sulfide (H2S) and cystathionine (CTH).	Homocysteine	116-128	cystathionine beta-synthase	Homo sapiens	0-27
25825818-2	2015	Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger, which is synthesized from L-cysteine by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	11-27	cystathionine beta-synthase	Homo sapiens	134-161
25825818-2	2015	Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger, which is synthesized from L-cysteine by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	11-27	cystathionine beta-synthase	Homo sapiens	163-166
25825818-2	2015	Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger, which is synthesized from L-cysteine by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	29-32	cystathionine beta-synthase	Homo sapiens	134-161
25825818-2	2015	Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger, which is synthesized from L-cysteine by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	29-32	cystathionine beta-synthase	Homo sapiens	163-166
25825818-2	2015	Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger, which is synthesized from L-cysteine by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Cysteine	120-130	cystathionine beta-synthase	Homo sapiens	134-161
25825818-2	2015	Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second messenger, which is synthesized from L-cysteine by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Cysteine	120-130	cystathionine beta-synthase	Homo sapiens	163-166
25825818-6	2015	Paraffin-embedded UA rings were used to localize CBS and CSE proteins by immunofluorescence microscopy.	Paraffin	0-8	cystathionine beta-synthase	Homo sapiens	49-52
25825818-11	2015	ERT-stimulated UA H2S production was completely blocked by a specific CBS but not CSE inhibitor.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	70-73
25825818-12	2015	Thus, ERT selectively stimulates UA and MA but not CA H2S biosynthesis by specifically up-regulating CBS expression, implicating a role of H2S in estrogen-induced vasodilation and postmenopausal women"s health.	Hydrogen Sulfide	139-142	cystathionine beta-synthase	Homo sapiens	101-104
25996214-5	2015	Biosynthesis of H2S in mammals depends upon two enzymes cystathionine-beta-synthase and cystathionine gamma-lyase.	Hydrogen Sulfide	16-19	cystathionine beta-synthase	Homo sapiens	56-83
25977470-1	2015	BACKGROUND: Cystathionine gamma-lyase, cystathionine beta-synthase, and 3-mercaptopyruvate sulfurtransferase are endogenous enzymatic sources of hydrogen sulfide (H2S).	Hydrogen Sulfide	145-161	cystathionine beta-synthase	Homo sapiens	39-66
25977470-1	2015	BACKGROUND: Cystathionine gamma-lyase, cystathionine beta-synthase, and 3-mercaptopyruvate sulfurtransferase are endogenous enzymatic sources of hydrogen sulfide (H2S).	Hydrogen Sulfide	163-166	cystathionine beta-synthase	Homo sapiens	39-66
25614252-1	2015	The aim of the present study was to evaluate the effects of heat stress (HS) and methionine supplementation on the markers of stress and on the gene expression levels of uncoupling proteins (UCP), betaine-homocysteine methyltransferase (BHMT), cystathionine beta-synthase (CBS), glutathione synthetase (GSS) and glutathione peroxidase 7 (GPx7).	Methionine	81-91	cystathionine beta-synthase	Homo sapiens	244-271
26962179-2	2015	The synthesis of the vasodilator hydrogen sulfide occurs through side reactions of the transsulfuration enzymes cystathionine beta-synthase and cystathionine gamma-lyase, with pyridoxal 5"-phosphate as a coenzyme.	Hydrogen Sulfide	33-49	cystathionine beta-synthase	Homo sapiens	112-139
26962179-2	2015	The synthesis of the vasodilator hydrogen sulfide occurs through side reactions of the transsulfuration enzymes cystathionine beta-synthase and cystathionine gamma-lyase, with pyridoxal 5"-phosphate as a coenzyme.	Pyridoxal Phosphate	176-198	cystathionine beta-synthase	Homo sapiens	112-139
25822632-8	2015	Taken together, we show that the H2S-synthesising enzymes CBS, CSE and 3-MST are endogenously expressed during adipogenesis and that both endogenous and exogenous H2S modulate adipogenesis and adipocyte maturation.	Hydrogen Sulfide	33-36	cystathionine beta-synthase	Homo sapiens	58-61
25822632-8	2015	Taken together, we show that the H2S-synthesising enzymes CBS, CSE and 3-MST are endogenously expressed during adipogenesis and that both endogenous and exogenous H2S modulate adipogenesis and adipocyte maturation.	Hydrogen Sulfide	163-166	cystathionine beta-synthase	Homo sapiens	58-61
25641403-2	2015	Cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) are two enzymes responsible for H2S production.	Hydrogen Sulfide	102-105	cystathionine beta-synthase	Homo sapiens	0-27
25666819-1	2015	A library consisting of characterized marine natural products as well as synthetic derivatives was screened for compounds capable of inhibiting the production of hydrogen sulfide (H2S) by cystathionine beta-synthase (CBS).	Hydrogen Sulfide	162-178	cystathionine beta-synthase	Homo sapiens	188-215
25666819-1	2015	A library consisting of characterized marine natural products as well as synthetic derivatives was screened for compounds capable of inhibiting the production of hydrogen sulfide (H2S) by cystathionine beta-synthase (CBS).	Hydrogen Sulfide	162-178	cystathionine beta-synthase	Homo sapiens	217-220
25666819-1	2015	A library consisting of characterized marine natural products as well as synthetic derivatives was screened for compounds capable of inhibiting the production of hydrogen sulfide (H2S) by cystathionine beta-synthase (CBS).	Hydrogen Sulfide	180-183	cystathionine beta-synthase	Homo sapiens	188-215
25666819-1	2015	A library consisting of characterized marine natural products as well as synthetic derivatives was screened for compounds capable of inhibiting the production of hydrogen sulfide (H2S) by cystathionine beta-synthase (CBS).	Hydrogen Sulfide	180-183	cystathionine beta-synthase	Homo sapiens	217-220
25331909-0	2015	Chaperone therapy for homocystinuria: the rescue of CBS mutations by heme arginate.	heme arginate	69-82	cystathionine beta-synthase	Homo sapiens	52-55
25331909-7	2015	In contrast, heme arginate substantially increased the formation of mutant CBS protein tetramers (up to sixfold) and rescued catalytic activity (up to ninefold) of five out of seven mutations (p.A114V, p.K102N, p.R125Q, p.R266K, and p.R369C).	heme arginate	13-26	cystathionine beta-synthase	Homo sapiens	75-78
25331909-10	2015	Based on these data, we propose that a distinct group of heme-responsive CBS mutations may exist and that the heme pocket of CBS may become an important target for designing novel therapies for homocystinuria.	Heme	57-61	cystathionine beta-synthase	Homo sapiens	73-76
25614252-1	2015	The aim of the present study was to evaluate the effects of heat stress (HS) and methionine supplementation on the markers of stress and on the gene expression levels of uncoupling proteins (UCP), betaine-homocysteine methyltransferase (BHMT), cystathionine beta-synthase (CBS), glutathione synthetase (GSS) and glutathione peroxidase 7 (GPx7).	Methionine	81-91	cystathionine beta-synthase	Homo sapiens	273-276
25614252-7	2015	The expression levels of the CBS and GPx7 genes were influenced by both the environment and methionine supplementation.	Methionine	92-102	cystathionine beta-synthase	Homo sapiens	29-32
24730679-2	2015	RECENT ADVANCES: In colorectal and ovarian cancers, an increase in the intratumor production of hydrogen sulfide (H2S) from cystathionine beta-synthase (CBS) plays an important role in promoting the cellular bioenergetics, proliferation, and migration of cancer cells.	Hydrogen Sulfide	96-112	cystathionine beta-synthase	Homo sapiens	124-151
24730679-2	2015	RECENT ADVANCES: In colorectal and ovarian cancers, an increase in the intratumor production of hydrogen sulfide (H2S) from cystathionine beta-synthase (CBS) plays an important role in promoting the cellular bioenergetics, proliferation, and migration of cancer cells.	Hydrogen Sulfide	96-112	cystathionine beta-synthase	Homo sapiens	153-156
24730679-2	2015	RECENT ADVANCES: In colorectal and ovarian cancers, an increase in the intratumor production of hydrogen sulfide (H2S) from cystathionine beta-synthase (CBS) plays an important role in promoting the cellular bioenergetics, proliferation, and migration of cancer cells.	Hydrogen Sulfide	114-117	cystathionine beta-synthase	Homo sapiens	124-151
24730679-2	2015	RECENT ADVANCES: In colorectal and ovarian cancers, an increase in the intratumor production of hydrogen sulfide (H2S) from cystathionine beta-synthase (CBS) plays an important role in promoting the cellular bioenergetics, proliferation, and migration of cancer cells.	Hydrogen Sulfide	114-117	cystathionine beta-synthase	Homo sapiens	153-156
24730679-5	2015	Next, the current state of the art of pharmacological CBS inhibitors is reviewed, with special reference to the complex pharmacological actions of aminooxyacetic acid.	Aminooxyacetic Acid	147-166	cystathionine beta-synthase	Homo sapiens	54-57
24800864-3	2015	H2S is produced from l-cysteine by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) along with cysteine aminotransferase.	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	35-62
24800864-3	2015	H2S is produced from l-cysteine by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) along with cysteine aminotransferase.	Cysteine	21-31	cystathionine beta-synthase	Homo sapiens	35-62
24893130-1	2015	AIMS: Cystathionine beta-synthase (CBS) catalyzes the first and rate-limiting step in the two-step trans-sulfuration pathway that converts homocysteine to cysteine.	Homocysteine	139-151	cystathionine beta-synthase	Homo sapiens	6-33
24893130-1	2015	AIMS: Cystathionine beta-synthase (CBS) catalyzes the first and rate-limiting step in the two-step trans-sulfuration pathway that converts homocysteine to cysteine.	Homocysteine	139-151	cystathionine beta-synthase	Homo sapiens	35-38
24893130-1	2015	AIMS: Cystathionine beta-synthase (CBS) catalyzes the first and rate-limiting step in the two-step trans-sulfuration pathway that converts homocysteine to cysteine.	Cysteine	143-151	cystathionine beta-synthase	Homo sapiens	6-33
24893130-1	2015	AIMS: Cystathionine beta-synthase (CBS) catalyzes the first and rate-limiting step in the two-step trans-sulfuration pathway that converts homocysteine to cysteine.	Cysteine	143-151	cystathionine beta-synthase	Homo sapiens	35-38
24893130-7	2015	To test the physiological relevance of S-glutathionylation-dependent regulation of CBS, HEK293 cells were oxidatively challenged with peroxide, which is known to enhance the trans-sulfuration flux.	Peroxides	134-142	cystathionine beta-synthase	Homo sapiens	83-86
24893130-9	2015	INNOVATION: Collectively, our results reveal a novel post-translational modification of CBS, that is, glutathionylation, which functions as an allosteric activator under oxidative stress conditions permitting enhanced synthesis of both cysteine and H2S.	Cysteine	236-244	cystathionine beta-synthase	Homo sapiens	88-91
24893130-9	2015	INNOVATION: Collectively, our results reveal a novel post-translational modification of CBS, that is, glutathionylation, which functions as an allosteric activator under oxidative stress conditions permitting enhanced synthesis of both cysteine and H2S.	Hydrogen Sulfide	249-252	cystathionine beta-synthase	Homo sapiens	88-91
24893130-10	2015	CONCLUSIONS: Our study elucidates a molecular mechanism for increased cysteine and therefore glutathione, synthesis via glutathionylation of CBS.	Cysteine	70-78	cystathionine beta-synthase	Homo sapiens	141-144
24893130-10	2015	CONCLUSIONS: Our study elucidates a molecular mechanism for increased cysteine and therefore glutathione, synthesis via glutathionylation of CBS.	Glutathione	93-104	cystathionine beta-synthase	Homo sapiens	141-144
24893130-11	2015	They also demonstrate the potential for increased H2S production under oxidative stress conditions, particularly in tissues where CBS is a major source of H2S.	Hydrogen Sulfide	50-53	cystathionine beta-synthase	Homo sapiens	130-133
24893130-11	2015	They also demonstrate the potential for increased H2S production under oxidative stress conditions, particularly in tissues where CBS is a major source of H2S.	Hydrogen Sulfide	155-158	cystathionine beta-synthase	Homo sapiens	130-133
25382675-0	2015	Towards high-level theoretical studies of large biodiesel molecules: an ONIOM [QCISD(T)/CBS:DFT] study of hydrogen abstraction reactions of C(n)H(2n+1)COOC(m)H(2m+1) + H. Recent interest in biodiesel combustion urges the need for the theoretical chemical kinetics of large alkyl ester molecules.	Hydrogen	106-114	cystathionine beta-synthase	Homo sapiens	88-91
25615598-3	2015	H2S is a gaseous signaling molecule and is produced endogenously by the enzymes cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (MPST).	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	80-107
25615598-3	2015	H2S is a gaseous signaling molecule and is produced endogenously by the enzymes cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (MPST).	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	109-112
25382675-2	2015	The hydrogen abstraction reactions of alky esters CnH2n+1COOCmH2m+1 (n = 1-5, 9, 15; m = 1, 2) by a hydrogen radical were investigated by a computational technique based on a two-layer ONIOM method, employing a QCISD(T)/CBS method for the high layer and a DFT method for the low layer.	Hydrogen	4-12	cystathionine beta-synthase	Homo sapiens	220-223
25382675-2	2015	The hydrogen abstraction reactions of alky esters CnH2n+1COOCmH2m+1 (n = 1-5, 9, 15; m = 1, 2) by a hydrogen radical were investigated by a computational technique based on a two-layer ONIOM method, employing a QCISD(T)/CBS method for the high layer and a DFT method for the low layer.	alky esters	38-49	cystathionine beta-synthase	Homo sapiens	220-223
25382675-2	2015	The hydrogen abstraction reactions of alky esters CnH2n+1COOCmH2m+1 (n = 1-5, 9, 15; m = 1, 2) by a hydrogen radical were investigated by a computational technique based on a two-layer ONIOM method, employing a QCISD(T)/CBS method for the high layer and a DFT method for the low layer.	cnh2n	50-55	cystathionine beta-synthase	Homo sapiens	220-223
25382675-2	2015	The hydrogen abstraction reactions of alky esters CnH2n+1COOCmH2m+1 (n = 1-5, 9, 15; m = 1, 2) by a hydrogen radical were investigated by a computational technique based on a two-layer ONIOM method, employing a QCISD(T)/CBS method for the high layer and a DFT method for the low layer.	1coocmh2m	56-65	cystathionine beta-synthase	Homo sapiens	220-223
25382675-2	2015	The hydrogen abstraction reactions of alky esters CnH2n+1COOCmH2m+1 (n = 1-5, 9, 15; m = 1, 2) by a hydrogen radical were investigated by a computational technique based on a two-layer ONIOM method, employing a QCISD(T)/CBS method for the high layer and a DFT method for the low layer.	monoprotium	100-116	cystathionine beta-synthase	Homo sapiens	220-223
25123509-2	2015	H2 S is produced from substances by three enzymes: cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (MST).	Hydrogen Sulfide	0-4	cystathionine beta-synthase	Homo sapiens	51-78
25218699-4	2015	Patients and methods CBS activity was measured in EDTA or heparin plasma using either a previously described or a newly developed LC-MS/MS method optimized for analysis of the reaction product, 3,3-(2)H2-cystathionine, as its butyl ester derivative.	Edetic Acid	50-54	cystathionine beta-synthase	Homo sapiens	21-24
25218699-4	2015	Patients and methods CBS activity was measured in EDTA or heparin plasma using either a previously described or a newly developed LC-MS/MS method optimized for analysis of the reaction product, 3,3-(2)H2-cystathionine, as its butyl ester derivative.	Heparin	58-65	cystathionine beta-synthase	Homo sapiens	21-24
25218699-4	2015	Patients and methods CBS activity was measured in EDTA or heparin plasma using either a previously described or a newly developed LC-MS/MS method optimized for analysis of the reaction product, 3,3-(2)H2-cystathionine, as its butyl ester derivative.	3,3-(2)h2-cystathionine	194-217	cystathionine beta-synthase	Homo sapiens	21-24
26162829-3	2015	H2S is produced from L-cysteine by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) together with cysteine aminotransferase (CAT).	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	35-62
26162829-3	2015	H2S is produced from L-cysteine by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) together with cysteine aminotransferase (CAT).	Cysteine	21-31	cystathionine beta-synthase	Homo sapiens	35-62
26162831-3	2015	Both cystathionine-beta synthase (CBS) and cystathionine-gamma lyase (CSE) are expressed in the human corpus cavernosum and exogenous H2S relaxes isolated human corpus cavernosum strips in an endothelium-independent manner.	Hydrogen Sulfide	134-137	cystathionine beta-synthase	Homo sapiens	5-32
25446078-7	2015	Further, the knockdown of cystathionine beta-synthetase (CBS) using siRNA decreased this modification in a manner that was correlated to amount of H2S.	Hydrogen Sulfide	147-150	cystathionine beta-synthase	Homo sapiens	26-55
25446078-7	2015	Further, the knockdown of cystathionine beta-synthetase (CBS) using siRNA decreased this modification in a manner that was correlated to amount of H2S.	Hydrogen Sulfide	147-150	cystathionine beta-synthase	Homo sapiens	57-60
25446078-9	2015	These results suggest that the endogenous S-sulfhydration of PTEN via CBS/H2S plays a role in preventing the S-nitrosylation that would inhibition its enzymatic activity under physiological conditions.	Hydrogen Sulfide	74-77	cystathionine beta-synthase	Homo sapiens	70-73
25493326-4	2015	The cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) system regulates homocysteine and cysteine metabolism and contributes to endogenous hydrogen sulfide (H2S) biosynthesis.	Hydrogen Sulfide	158-174	cystathionine beta-synthase	Homo sapiens	4-31
25493326-4	2015	The cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) system regulates homocysteine and cysteine metabolism and contributes to endogenous hydrogen sulfide (H2S) biosynthesis.	Hydrogen Sulfide	158-174	cystathionine beta-synthase	Homo sapiens	33-36
25493326-4	2015	The cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) system regulates homocysteine and cysteine metabolism and contributes to endogenous hydrogen sulfide (H2S) biosynthesis.	Hydrogen Sulfide	176-179	cystathionine beta-synthase	Homo sapiens	4-31
25493326-4	2015	The cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) system regulates homocysteine and cysteine metabolism and contributes to endogenous hydrogen sulfide (H2S) biosynthesis.	Hydrogen Sulfide	176-179	cystathionine beta-synthase	Homo sapiens	33-36
26162838-2	2015	This is particularly evident in cancers of the colon and ovaries, where the malignant cells both overexpress cystathionine-beta-synthase (CBS) and produce increased amounts of H2S, which enhances tumor growth and spread by (a) stimulating cellular bioenergetics, (b) activating proliferative, migratory, and invasive signaling pathways, and (c) enhancing tumor angiogenesis.	Hydrogen Sulfide	176-179	cystathionine beta-synthase	Homo sapiens	138-141
25123509-11	2015	H2 S is produced from cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfur transferase (MST).	Hydrogen Sulfide	0-4	cystathionine beta-synthase	Homo sapiens	22-49
25725523-1	2015	H2S is produced from sulfur-containing amino acids, cysteine and homocysteine, or a catabolite, 3-mercaptopyruvate, by three known enzymes: cystathionine beta-synthase, gamma-cystathionase, and 3-mercaptopyruvate sulfurtransferase.	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	140-167
25725523-1	2015	H2S is produced from sulfur-containing amino acids, cysteine and homocysteine, or a catabolite, 3-mercaptopyruvate, by three known enzymes: cystathionine beta-synthase, gamma-cystathionase, and 3-mercaptopyruvate sulfurtransferase.	Sulfur	21-27	cystathionine beta-synthase	Homo sapiens	140-167
25725523-1	2015	H2S is produced from sulfur-containing amino acids, cysteine and homocysteine, or a catabolite, 3-mercaptopyruvate, by three known enzymes: cystathionine beta-synthase, gamma-cystathionase, and 3-mercaptopyruvate sulfurtransferase.	Cysteine	52-60	cystathionine beta-synthase	Homo sapiens	140-167
25725523-1	2015	H2S is produced from sulfur-containing amino acids, cysteine and homocysteine, or a catabolite, 3-mercaptopyruvate, by three known enzymes: cystathionine beta-synthase, gamma-cystathionase, and 3-mercaptopyruvate sulfurtransferase.	Homocysteine	65-77	cystathionine beta-synthase	Homo sapiens	140-167
25725523-1	2015	H2S is produced from sulfur-containing amino acids, cysteine and homocysteine, or a catabolite, 3-mercaptopyruvate, by three known enzymes: cystathionine beta-synthase, gamma-cystathionase, and 3-mercaptopyruvate sulfurtransferase.	catabolite	84-94	cystathionine beta-synthase	Homo sapiens	140-167
25725523-1	2015	H2S is produced from sulfur-containing amino acids, cysteine and homocysteine, or a catabolite, 3-mercaptopyruvate, by three known enzymes: cystathionine beta-synthase, gamma-cystathionase, and 3-mercaptopyruvate sulfurtransferase.	3-mercaptopyruvic acid	96-114	cystathionine beta-synthase	Homo sapiens	140-167
25747479-2	2015	Expression of the H2S biosynthetic enzymes cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS) is induced in response to T cell receptor signaling.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	79-106
25747479-2	2015	Expression of the H2S biosynthetic enzymes cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS) is induced in response to T cell receptor signaling.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	108-111
26078809-1	2015	Hydrogen sulfide (H2S), produced endogenously by the activation of two major H2S-generating enzymes (cystathionine beta-synthase and cystathionine gamma-lyase), plays important regulatory roles in different physiologic and pathologic conditions.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	101-128
26078809-1	2015	Hydrogen sulfide (H2S), produced endogenously by the activation of two major H2S-generating enzymes (cystathionine beta-synthase and cystathionine gamma-lyase), plays important regulatory roles in different physiologic and pathologic conditions.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	101-128
26078818-2	2015	Three enzymes, cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (MST), are involved in enzymatic production of H2S.	Hydrogen Sulfide	171-174	cystathionine beta-synthase	Homo sapiens	15-42
26078818-2	2015	Three enzymes, cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (MST), are involved in enzymatic production of H2S.	Hydrogen Sulfide	171-174	cystathionine beta-synthase	Homo sapiens	44-47
26078809-1	2015	Hydrogen sulfide (H2S), produced endogenously by the activation of two major H2S-generating enzymes (cystathionine beta-synthase and cystathionine gamma-lyase), plays important regulatory roles in different physiologic and pathologic conditions.	Hydrogen Sulfide	77-80	cystathionine beta-synthase	Homo sapiens	101-128
26078811-1	2015	Hydrogen sulfide (H2S) can be synthesized in mammalian cells by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	103-130
26078811-1	2015	Hydrogen sulfide (H2S) can be synthesized in mammalian cells by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	132-135
26078811-1	2015	Hydrogen sulfide (H2S) can be synthesized in mammalian cells by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS).	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	103-130
26078811-1	2015	Hydrogen sulfide (H2S) can be synthesized in mammalian cells by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS).	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	132-135
25864468-3	2015	Enzymes that produce H2S, such as cystathionine beta-synthase, cystathionine gamma-lyase, and 3-mercaptopyruvate sulfurtransferase have been studied intensively and well characterized.	Hydrogen Sulfide	21-24	cystathionine beta-synthase	Homo sapiens	34-61
25205294-1	2015	In humans, two main metabolic enzymes synthesize hydrogen sulfide (H2 S): cystathionine gamma lyase (CSE) and cystathionine beta synthase (CBS).	Hydrogen Sulfide	49-65	cystathionine beta-synthase	Homo sapiens	110-137
25205294-1	2015	In humans, two main metabolic enzymes synthesize hydrogen sulfide (H2 S): cystathionine gamma lyase (CSE) and cystathionine beta synthase (CBS).	Hydrogen Sulfide	49-65	cystathionine beta-synthase	Homo sapiens	139-142
25205294-1	2015	In humans, two main metabolic enzymes synthesize hydrogen sulfide (H2 S): cystathionine gamma lyase (CSE) and cystathionine beta synthase (CBS).	Hydrogen Sulfide	67-71	cystathionine beta-synthase	Homo sapiens	110-137
25205294-1	2015	In humans, two main metabolic enzymes synthesize hydrogen sulfide (H2 S): cystathionine gamma lyase (CSE) and cystathionine beta synthase (CBS).	Hydrogen Sulfide	67-71	cystathionine beta-synthase	Homo sapiens	139-142
25539831-2	2014	Kidney has a high expression of cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) that can synthesize hydrogen sulfide.	Hydrogen Sulfide	122-138	cystathionine beta-synthase	Homo sapiens	32-59
25336647-0	2014	Inter-domain communication of human cystathionine beta-synthase: structural basis of S-adenosyl-L-methionine activation.	Sulfur	85-86	cystathionine beta-synthase	Homo sapiens	36-63
25336647-0	2014	Inter-domain communication of human cystathionine beta-synthase: structural basis of S-adenosyl-L-methionine activation.	S-Adenosylmethionine	87-108	cystathionine beta-synthase	Homo sapiens	36-63
25336647-1	2014	Cystathionine beta-synthase (CBS) is a key enzyme in sulfur metabolism, and its inherited deficiency causes homocystinuria.	Sulfur	53-59	cystathionine beta-synthase	Homo sapiens	0-27
25539831-2	2014	Kidney has a high expression of cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) that can synthesize hydrogen sulfide.	Hydrogen Sulfide	122-138	cystathionine beta-synthase	Homo sapiens	61-64
25445596-3	2014	We showed that two H2S-producing enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), were significantly downregulated in human osteonecrosis tissues as well as in Dex-treated osteoblastic MC3T3-E1 cells.	Dexamethasone	191-194	cystathionine beta-synthase	Homo sapiens	42-69
24702258-2	2014	Recently, hydrogen sulfide (H2S), a gaseous transmitter endogenously produced by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE), has been found to improve mitochondrial function.	Hydrogen Sulfide	10-26	cystathionine beta-synthase	Homo sapiens	81-108
24702258-2	2014	Recently, hydrogen sulfide (H2S), a gaseous transmitter endogenously produced by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE), has been found to improve mitochondrial function.	Hydrogen Sulfide	10-26	cystathionine beta-synthase	Homo sapiens	110-113
24702258-2	2014	Recently, hydrogen sulfide (H2S), a gaseous transmitter endogenously produced by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE), has been found to improve mitochondrial function.	Hydrogen Sulfide	28-31	cystathionine beta-synthase	Homo sapiens	81-108
24702258-2	2014	Recently, hydrogen sulfide (H2S), a gaseous transmitter endogenously produced by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE), has been found to improve mitochondrial function.	Hydrogen Sulfide	28-31	cystathionine beta-synthase	Homo sapiens	110-113
24702258-4	2014	RESULTS: Both CBS and CSE are present in murine adrenocortical cells and account for H2S generation in adrenal glands.	Hydrogen Sulfide	85-88	cystathionine beta-synthase	Homo sapiens	14-17
24702258-5	2014	Using a combination of both in vivo and in vitro approaches, we demonstrated that either CBS/CSE inhibitors or small interfering RNAs led to mitochondrial oxidative stress and dysfunction, which meanwhile resulted in blunted corticosterone responses to adrenocorticotropic hormone (ACTH).	Corticosterone	225-239	cystathionine beta-synthase	Homo sapiens	89-92
25008174-4	2014	HHcy was established in mice deficient in cystathionine beta-synthase (Cbs) in which the homocysteine (Hcy) level could be lowered by inducing transgenic human CBS (Tg-hCBS) using Zn supplementation.	Homocysteine	89-101	cystathionine beta-synthase	Homo sapiens	160-163
25008174-4	2014	HHcy was established in mice deficient in cystathionine beta-synthase (Cbs) in which the homocysteine (Hcy) level could be lowered by inducing transgenic human CBS (Tg-hCBS) using Zn supplementation.	Homocysteine	1-4	cystathionine beta-synthase	Homo sapiens	160-163
25008174-4	2014	HHcy was established in mice deficient in cystathionine beta-synthase (Cbs) in which the homocysteine (Hcy) level could be lowered by inducing transgenic human CBS (Tg-hCBS) using Zn supplementation.	tg-hcbs	165-172	cystathionine beta-synthase	Homo sapiens	160-163
25624861-1	2014	INTRODUCTION: The cystathionine beta synthase (CBS) gene plays an important role in homocysteine metabolism because it catalyzes the first step of the transsulfuration pathway, during which homocysteine is converted to cystathionine.	Homocysteine	84-96	cystathionine beta-synthase	Homo sapiens	18-45
25624861-1	2014	INTRODUCTION: The cystathionine beta synthase (CBS) gene plays an important role in homocysteine metabolism because it catalyzes the first step of the transsulfuration pathway, during which homocysteine is converted to cystathionine.	Homocysteine	84-96	cystathionine beta-synthase	Homo sapiens	47-50
25624861-1	2014	INTRODUCTION: The cystathionine beta synthase (CBS) gene plays an important role in homocysteine metabolism because it catalyzes the first step of the transsulfuration pathway, during which homocysteine is converted to cystathionine.	Homocysteine	190-202	cystathionine beta-synthase	Homo sapiens	18-45
25624861-1	2014	INTRODUCTION: The cystathionine beta synthase (CBS) gene plays an important role in homocysteine metabolism because it catalyzes the first step of the transsulfuration pathway, during which homocysteine is converted to cystathionine.	Homocysteine	190-202	cystathionine beta-synthase	Homo sapiens	47-50
25624861-1	2014	INTRODUCTION: The cystathionine beta synthase (CBS) gene plays an important role in homocysteine metabolism because it catalyzes the first step of the transsulfuration pathway, during which homocysteine is converted to cystathionine.	Cystathionine	18-31	cystathionine beta-synthase	Homo sapiens	47-50
24766279-5	2014	RESULTS: Application of exogenous H2S with its donor, NaHS, or overexpression of its generating enzyme, cystathionine beta-synthase, induced sulfhydration of p66Shc, but inhibited its phosphorylation caused by H2O2/D-galactose in SH-SY5Y cells or in the mice cortex.	Hydrogen Peroxide	210-214	cystathionine beta-synthase	Homo sapiens	104-131
24766279-5	2014	RESULTS: Application of exogenous H2S with its donor, NaHS, or overexpression of its generating enzyme, cystathionine beta-synthase, induced sulfhydration of p66Shc, but inhibited its phosphorylation caused by H2O2/D-galactose in SH-SY5Y cells or in the mice cortex.	Galactose	215-226	cystathionine beta-synthase	Homo sapiens	104-131
25456744-4	2014	In animal models, elevated Hcy concentrations are induced either by diet (high methionine, low B-vitamins, or both), gene knockouts (Mthfr, Cbs, Mtrr or Mtr) or combination of both to investigate their effects on DNA methylation or its markers.	Homocysteine	27-30	cystathionine beta-synthase	Homo sapiens	140-143
25165392-2	2014	PLP-dependent enzymes, cystathionine beta-synthase and cystathionine gamma-lyase, function in transsulfuration but also have been implicated in the production of the endogenous gaseous signaling molecule hydrogen sulfide (H2S) concurrent with the formation of the biomarkers lanthionine and homolanthionine.	Hydrogen Sulfide	204-220	cystathionine beta-synthase	Homo sapiens	23-50
25170978-2	2014	In this respect, the fixed-node diffusion Monte Carlo (FN-DMC) method is a promising alternative to the commonly used "gold standard" coupled-cluster CCSD(T)/CBS method due to its benchmark accuracy and favourable scaling, in contrast to other correlated wave function approaches.	methyl carbonate	58-61	cystathionine beta-synthase	Homo sapiens	158-161
25077524-1	2014	Hydrogen sulfide (H2S) is a gaseous mediator synthesized in mammalian tissues by three main enzymes-cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE), and 3-mercaptopyruvate-sulfurtransferase-and its levels increase under inflammatory conditions or sepsis.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	92-127
25044645-1	2014	Cystathionine beta-synthase (CBS) catalyzes the formation of cystathionine from homocysteine and serine.	Cystathionine	61-74	cystathionine beta-synthase	Homo sapiens	0-27
25044645-1	2014	Cystathionine beta-synthase (CBS) catalyzes the formation of cystathionine from homocysteine and serine.	Cystathionine	61-74	cystathionine beta-synthase	Homo sapiens	29-32
25044645-1	2014	Cystathionine beta-synthase (CBS) catalyzes the formation of cystathionine from homocysteine and serine.	Homocysteine	80-92	cystathionine beta-synthase	Homo sapiens	0-27
25044645-1	2014	Cystathionine beta-synthase (CBS) catalyzes the formation of cystathionine from homocysteine and serine.	Homocysteine	80-92	cystathionine beta-synthase	Homo sapiens	29-32
25044645-1	2014	Cystathionine beta-synthase (CBS) catalyzes the formation of cystathionine from homocysteine and serine.	Serine	97-103	cystathionine beta-synthase	Homo sapiens	0-27
25044645-1	2014	Cystathionine beta-synthase (CBS) catalyzes the formation of cystathionine from homocysteine and serine.	Serine	97-103	cystathionine beta-synthase	Homo sapiens	29-32
25044645-2	2014	CBS is allosterically activated by S-adenosylmethionine (SAM), which binds to its C-terminal regulatory domain.	S-Adenosylmethionine	35-55	cystathionine beta-synthase	Homo sapiens	0-3
25044645-2	2014	CBS is allosterically activated by S-adenosylmethionine (SAM), which binds to its C-terminal regulatory domain.	S-Adenosylmethionine	57-60	cystathionine beta-synthase	Homo sapiens	0-3
25077524-1	2014	Hydrogen sulfide (H2S) is a gaseous mediator synthesized in mammalian tissues by three main enzymes-cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE), and 3-mercaptopyruvate-sulfurtransferase-and its levels increase under inflammatory conditions or sepsis.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	129-132
25077524-1	2014	Hydrogen sulfide (H2S) is a gaseous mediator synthesized in mammalian tissues by three main enzymes-cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE), and 3-mercaptopyruvate-sulfurtransferase-and its levels increase under inflammatory conditions or sepsis.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	92-127
25165392-2	2014	PLP-dependent enzymes, cystathionine beta-synthase and cystathionine gamma-lyase, function in transsulfuration but also have been implicated in the production of the endogenous gaseous signaling molecule hydrogen sulfide (H2S) concurrent with the formation of the biomarkers lanthionine and homolanthionine.	Hydrogen Sulfide	222-225	cystathionine beta-synthase	Homo sapiens	23-50
25077524-1	2014	Hydrogen sulfide (H2S) is a gaseous mediator synthesized in mammalian tissues by three main enzymes-cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE), and 3-mercaptopyruvate-sulfurtransferase-and its levels increase under inflammatory conditions or sepsis.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	129-132
25165392-2	2014	PLP-dependent enzymes, cystathionine beta-synthase and cystathionine gamma-lyase, function in transsulfuration but also have been implicated in the production of the endogenous gaseous signaling molecule hydrogen sulfide (H2S) concurrent with the formation of the biomarkers lanthionine and homolanthionine.	lanthionine	275-286	cystathionine beta-synthase	Homo sapiens	23-50
25165392-2	2014	PLP-dependent enzymes, cystathionine beta-synthase and cystathionine gamma-lyase, function in transsulfuration but also have been implicated in the production of the endogenous gaseous signaling molecule hydrogen sulfide (H2S) concurrent with the formation of the biomarkers lanthionine and homolanthionine.	L-Homolanthionine	291-306	cystathionine beta-synthase	Homo sapiens	23-50
24667534-1	2014	Recent data show that colon cancer cells selectively overexpress cystathionine-beta-synthase (CBS), which produces hydrogen sulfide (H2S), to maintain cellular bioenergetics, support tumor growth and stimulate angiogenesis and vasorelaxation in the tumor microenvironment.	Hydrogen Sulfide	133-136	cystathionine beta-synthase	Homo sapiens	94-97
25197074-0	2014	Structural insight into the molecular mechanism of allosteric activation of human cystathionine beta-synthase by S-adenosylmethionine.	S-Adenosylmethionine	113-133	cystathionine beta-synthase	Homo sapiens	82-109
25197074-1	2014	Cystathionine beta-synthase (CBS) is a heme-dependent and pyridoxal-5"-phosphate-dependent protein that controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H2S.	Sulfur	125-131	cystathionine beta-synthase	Homo sapiens	0-27
25197074-1	2014	Cystathionine beta-synthase (CBS) is a heme-dependent and pyridoxal-5"-phosphate-dependent protein that controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H2S.	Methionine	137-147	cystathionine beta-synthase	Homo sapiens	0-27
25197074-1	2014	Cystathionine beta-synthase (CBS) is a heme-dependent and pyridoxal-5"-phosphate-dependent protein that controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H2S.	Cysteine	151-159	cystathionine beta-synthase	Homo sapiens	0-27
25197074-1	2014	Cystathionine beta-synthase (CBS) is a heme-dependent and pyridoxal-5"-phosphate-dependent protein that controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H2S.	Glutathione	176-187	cystathionine beta-synthase	Homo sapiens	0-27
25197074-1	2014	Cystathionine beta-synthase (CBS) is a heme-dependent and pyridoxal-5"-phosphate-dependent protein that controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H2S.	Taurine	189-196	cystathionine beta-synthase	Homo sapiens	0-27
25197074-1	2014	Cystathionine beta-synthase (CBS) is a heme-dependent and pyridoxal-5"-phosphate-dependent protein that controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H2S.	Hydrogen Sulfide	202-205	cystathionine beta-synthase	Homo sapiens	0-27
24491257-2	2014	H2S is produced from L-cysteine by enzymes such as cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), 3-mercaptopyruvate sulfurtransferase (3MST), and cysteine aminotransferase (CAT).	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	51-78
24491257-2	2014	H2S is produced from L-cysteine by enzymes such as cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), 3-mercaptopyruvate sulfurtransferase (3MST), and cysteine aminotransferase (CAT).	Cysteine	21-31	cystathionine beta-synthase	Homo sapiens	51-78
24994751-1	2014	UNLABELLED: Cystathionine beta-synthase (CBS) catalyzes metabolic reactions that convert homocysteine to cystathionine.	Homocysteine	89-101	cystathionine beta-synthase	Homo sapiens	12-39
24994751-1	2014	UNLABELLED: Cystathionine beta-synthase (CBS) catalyzes metabolic reactions that convert homocysteine to cystathionine.	Homocysteine	89-101	cystathionine beta-synthase	Homo sapiens	41-44
24994751-1	2014	UNLABELLED: Cystathionine beta-synthase (CBS) catalyzes metabolic reactions that convert homocysteine to cystathionine.	Cystathionine	105-118	cystathionine beta-synthase	Homo sapiens	12-39
24994751-1	2014	UNLABELLED: Cystathionine beta-synthase (CBS) catalyzes metabolic reactions that convert homocysteine to cystathionine.	Cystathionine	105-118	cystathionine beta-synthase	Homo sapiens	41-44
25248148-5	2014	Inhibition of cystathionine beta synthase (CBS) or cystathionase (CTH), enzymes which drive generation of H2S, decreases Nampt production while suppression of Nampt pathway by FK866, decreases H2S and ATP levels.	Hydrogen Sulfide	106-109	cystathionine beta-synthase	Homo sapiens	14-41
25248148-5	2014	Inhibition of cystathionine beta synthase (CBS) or cystathionase (CTH), enzymes which drive generation of H2S, decreases Nampt production while suppression of Nampt pathway by FK866, decreases H2S and ATP levels.	N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide	176-181	cystathionine beta-synthase	Homo sapiens	14-41
25248148-5	2014	Inhibition of cystathionine beta synthase (CBS) or cystathionase (CTH), enzymes which drive generation of H2S, decreases Nampt production while suppression of Nampt pathway by FK866, decreases H2S and ATP levels.	Hydrogen Sulfide	193-196	cystathionine beta-synthase	Homo sapiens	14-41
25248148-5	2014	Inhibition of cystathionine beta synthase (CBS) or cystathionase (CTH), enzymes which drive generation of H2S, decreases Nampt production while suppression of Nampt pathway by FK866, decreases H2S and ATP levels.	Adenosine Triphosphate	201-204	cystathionine beta-synthase	Homo sapiens	14-41
24667534-2	2014	The purpose of the current study was to investigate the effect of the allosteric CBS activator S-adenosyl-L-methionine (SAM) on the proliferation and bioenergetics of the CBS-expressing colon cancer cell line HCT116.	S-Adenosylmethionine	95-118	cystathionine beta-synthase	Homo sapiens	81-84
24667534-2	2014	The purpose of the current study was to investigate the effect of the allosteric CBS activator S-adenosyl-L-methionine (SAM) on the proliferation and bioenergetics of the CBS-expressing colon cancer cell line HCT116.	S-Adenosylmethionine	95-118	cystathionine beta-synthase	Homo sapiens	171-174
24582857-2	2014	Enzymatic production of H2S is catalyzed by cystathionine gamma-lyase (CSE), cystathionine beta-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (MST).	Hydrogen Sulfide	24-27	cystathionine beta-synthase	Homo sapiens	77-104
24667534-7	2014	SAM markedly enhanced CBS-mediated H2S production in vitro, especially when a combination of cysteine and homocysteine was used as substrates.	Hydrogen Sulfide	35-38	cystathionine beta-synthase	Homo sapiens	22-25
24667534-7	2014	SAM markedly enhanced CBS-mediated H2S production in vitro, especially when a combination of cysteine and homocysteine was used as substrates.	Cysteine	93-101	cystathionine beta-synthase	Homo sapiens	22-25
24667534-0	2014	Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-beta-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro.	S-Adenosylmethionine	10-33	cystathionine beta-synthase	Homo sapiens	68-95
24667534-0	2014	Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-beta-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro.	S-Adenosylmethionine	10-33	cystathionine beta-synthase	Homo sapiens	97-100
24667534-7	2014	SAM markedly enhanced CBS-mediated H2S production in vitro, especially when a combination of cysteine and homocysteine was used as substrates.	Homocysteine	106-118	cystathionine beta-synthase	Homo sapiens	22-25
24667534-0	2014	Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-beta-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro.	S-Adenosylmethionine	35-38	cystathionine beta-synthase	Homo sapiens	68-95
24667534-0	2014	Effect of S-adenosyl-L-methionine (SAM), an allosteric activator of cystathionine-beta-synthase (CBS) on colorectal cancer cell proliferation and bioenergetics in vitro.	S-Adenosylmethionine	35-38	cystathionine beta-synthase	Homo sapiens	97-100
24667534-12	2014	The short-term stimulatory effects of SAM were attenuated by the CBS inhibitor aminooxyacetic acid (AOAA) or by stable silencing of CBS.	Aminooxyacetic Acid	79-98	cystathionine beta-synthase	Homo sapiens	65-68
24667534-1	2014	Recent data show that colon cancer cells selectively overexpress cystathionine-beta-synthase (CBS), which produces hydrogen sulfide (H2S), to maintain cellular bioenergetics, support tumor growth and stimulate angiogenesis and vasorelaxation in the tumor microenvironment.	Hydrogen Sulfide	115-131	cystathionine beta-synthase	Homo sapiens	65-92
24667534-12	2014	The short-term stimulatory effects of SAM were attenuated by the CBS inhibitor aminooxyacetic acid (AOAA) or by stable silencing of CBS.	Aminooxyacetic Acid	100-104	cystathionine beta-synthase	Homo sapiens	65-68
24667534-1	2014	Recent data show that colon cancer cells selectively overexpress cystathionine-beta-synthase (CBS), which produces hydrogen sulfide (H2S), to maintain cellular bioenergetics, support tumor growth and stimulate angiogenesis and vasorelaxation in the tumor microenvironment.	Hydrogen Sulfide	115-131	cystathionine beta-synthase	Homo sapiens	94-97
24667534-1	2014	Recent data show that colon cancer cells selectively overexpress cystathionine-beta-synthase (CBS), which produces hydrogen sulfide (H2S), to maintain cellular bioenergetics, support tumor growth and stimulate angiogenesis and vasorelaxation in the tumor microenvironment.	Hydrogen Sulfide	133-136	cystathionine beta-synthase	Homo sapiens	65-92
24667534-20	2014	Taken together, the results demonstrate that H2S production in HCT116 cells is stimulated by the allosteric CBS activator, SAM.	Hydrogen Sulfide	45-48	cystathionine beta-synthase	Homo sapiens	108-111
24780582-1	2014	Human cystathionine beta-synthase (hCBS) is a key enzyme of sulfur amino acid metabolism, controlling the commitment of homocysteine to the transsulfuration pathway and antioxidant defense.	Amino Acids, Sulfur	60-77	cystathionine beta-synthase	Homo sapiens	6-33
24780582-1	2014	Human cystathionine beta-synthase (hCBS) is a key enzyme of sulfur amino acid metabolism, controlling the commitment of homocysteine to the transsulfuration pathway and antioxidant defense.	Amino Acids, Sulfur	60-77	cystathionine beta-synthase	Homo sapiens	35-39
24780582-1	2014	Human cystathionine beta-synthase (hCBS) is a key enzyme of sulfur amino acid metabolism, controlling the commitment of homocysteine to the transsulfuration pathway and antioxidant defense.	Homocysteine	120-132	cystathionine beta-synthase	Homo sapiens	6-33
24780582-1	2014	Human cystathionine beta-synthase (hCBS) is a key enzyme of sulfur amino acid metabolism, controlling the commitment of homocysteine to the transsulfuration pathway and antioxidant defense.	Homocysteine	120-132	cystathionine beta-synthase	Homo sapiens	35-39
24780582-3	2014	hCBS is a complex multidomain and oligomeric protein whose activity and stability are independently regulated by the binding of S-adenosyl-methionine (SAM) to two different types of sites at its C-terminal regulatory domain.	S-Adenosylmethionine	128-149	cystathionine beta-synthase	Homo sapiens	0-4
24780582-3	2014	hCBS is a complex multidomain and oligomeric protein whose activity and stability are independently regulated by the binding of S-adenosyl-methionine (SAM) to two different types of sites at its C-terminal regulatory domain.	S-Adenosylmethionine	151-154	cystathionine beta-synthase	Homo sapiens	0-4
25122507-1	2014	Cystathionine beta-synthase (CBS) is a key regulator of sulfur amino acid metabolism diverting homocysteine, a toxic intermediate of the methionine cycle, via the transsulfuration pathway to the biosynthesis of cysteine.	Amino Acids, Sulfur	56-73	cystathionine beta-synthase	Homo sapiens	0-27
24980266-0	2014	Stacking of benzene with metal chelates: calculated CCSD(T)/CBS interaction energies and potential-energy curves.	Benzene	12-19	cystathionine beta-synthase	Homo sapiens	60-63
24980266-1	2014	Accurate values for the energies of stacking interactions of nickel- and copper-based six-membered chelate rings with benzene are calculated at the CCSD(T)/CBS level.	Nickel	61-67	cystathionine beta-synthase	Homo sapiens	156-159
24980266-1	2014	Accurate values for the energies of stacking interactions of nickel- and copper-based six-membered chelate rings with benzene are calculated at the CCSD(T)/CBS level.	Copper	73-79	cystathionine beta-synthase	Homo sapiens	156-159
24980266-1	2014	Accurate values for the energies of stacking interactions of nickel- and copper-based six-membered chelate rings with benzene are calculated at the CCSD(T)/CBS level.	Benzene	118-125	cystathionine beta-synthase	Homo sapiens	156-159
25122507-1	2014	Cystathionine beta-synthase (CBS) is a key regulator of sulfur amino acid metabolism diverting homocysteine, a toxic intermediate of the methionine cycle, via the transsulfuration pathway to the biosynthesis of cysteine.	Amino Acids, Sulfur	56-73	cystathionine beta-synthase	Homo sapiens	29-32
25122507-1	2014	Cystathionine beta-synthase (CBS) is a key regulator of sulfur amino acid metabolism diverting homocysteine, a toxic intermediate of the methionine cycle, via the transsulfuration pathway to the biosynthesis of cysteine.	Homocysteine	95-107	cystathionine beta-synthase	Homo sapiens	0-27
25122507-1	2014	Cystathionine beta-synthase (CBS) is a key regulator of sulfur amino acid metabolism diverting homocysteine, a toxic intermediate of the methionine cycle, via the transsulfuration pathway to the biosynthesis of cysteine.	Homocysteine	95-107	cystathionine beta-synthase	Homo sapiens	29-32
25122507-1	2014	Cystathionine beta-synthase (CBS) is a key regulator of sulfur amino acid metabolism diverting homocysteine, a toxic intermediate of the methionine cycle, via the transsulfuration pathway to the biosynthesis of cysteine.	Methionine	137-147	cystathionine beta-synthase	Homo sapiens	0-27
25122507-1	2014	Cystathionine beta-synthase (CBS) is a key regulator of sulfur amino acid metabolism diverting homocysteine, a toxic intermediate of the methionine cycle, via the transsulfuration pathway to the biosynthesis of cysteine.	Methionine	137-147	cystathionine beta-synthase	Homo sapiens	29-32
25122507-1	2014	Cystathionine beta-synthase (CBS) is a key regulator of sulfur amino acid metabolism diverting homocysteine, a toxic intermediate of the methionine cycle, via the transsulfuration pathway to the biosynthesis of cysteine.	Cysteine	99-107	cystathionine beta-synthase	Homo sapiens	0-27
25122507-1	2014	Cystathionine beta-synthase (CBS) is a key regulator of sulfur amino acid metabolism diverting homocysteine, a toxic intermediate of the methionine cycle, via the transsulfuration pathway to the biosynthesis of cysteine.	Cysteine	99-107	cystathionine beta-synthase	Homo sapiens	29-32
25122507-6	2014	The dCBS and yCBS are not regulated by the allosteric activator of hCBS, S-adenosylmethionine (AdoMet); however, they have significantly higher specific activities in the canonical as well as alternative reactions compared to hCBS.	S-(Benzo[d]thiazol-2-yl)-N,N-dicyclohexylthiohydroxylamine	4-8	cystathionine beta-synthase	Homo sapiens	226-230
25122507-6	2014	The dCBS and yCBS are not regulated by the allosteric activator of hCBS, S-adenosylmethionine (AdoMet); however, they have significantly higher specific activities in the canonical as well as alternative reactions compared to hCBS.	ycbs	13-17	cystathionine beta-synthase	Homo sapiens	226-230
25122507-7	2014	Unlike yCBS, the heme-containing dCBS and hCBS showed increased thermal stability and retention of the enzyme"s catalytic activity.	Heme	17-21	cystathionine beta-synthase	Homo sapiens	42-46
24284510-4	2014	Cystathionine-beta-synthase, a hydrogen sulfide-producing enzyme, was dramatically reduced in the ureteral obstructed kidney, but another enzyme cystathionine-gamma-lyase was increased.	Hydrogen Sulfide	31-47	cystathionine beta-synthase	Homo sapiens	0-27
24746521-1	2014	Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST).	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	147-174
24746521-1	2014	Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST).	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	176-179
24746521-1	2014	Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST).	Cysteine	91-99	cystathionine beta-synthase	Homo sapiens	147-174
24746521-1	2014	Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST).	Cysteine	91-99	cystathionine beta-synthase	Homo sapiens	176-179
24746521-1	2014	Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST).	Cysteine	101-104	cystathionine beta-synthase	Homo sapiens	147-174
24746521-1	2014	Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST).	Cysteine	101-104	cystathionine beta-synthase	Homo sapiens	176-179
24746521-1	2014	Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST).	Homocysteine	110-122	cystathionine beta-synthase	Homo sapiens	147-174
24746521-1	2014	Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST).	Homocysteine	110-122	cystathionine beta-synthase	Homo sapiens	176-179
24746521-1	2014	Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST).	Homocysteine	124-127	cystathionine beta-synthase	Homo sapiens	147-174
24746521-1	2014	Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST).	Homocysteine	124-127	cystathionine beta-synthase	Homo sapiens	176-179
24746521-1	2014	Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	147-174
24746521-1	2014	Hydrogen sulfide (H2S) is a well known toxic gas that is synthesized from the amino acids: cysteine (Cys) and homocysteine (Hcy) by three enzymes: cystathionine-beta-synthase (CBS), cystathionine-gamma-lyase (CSE) and mercaptopyruvate sulfurtransferase (3-MST).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	176-179
24914509-2	2014	Hydrogen sulphide (H2S) is a gaseotransmitter produced mainly by cystathionine-gamma-lyase and cystathionine-beta-synthase.	Hydrogen Sulfide	0-17	cystathionine beta-synthase	Homo sapiens	95-122
24914509-2	2014	Hydrogen sulphide (H2S) is a gaseotransmitter produced mainly by cystathionine-gamma-lyase and cystathionine-beta-synthase.	Hydrogen Sulfide	19-22	cystathionine beta-synthase	Homo sapiens	95-122
24914509-3	2014	Here we show that cystathionine-gamma-lyase and cystathionine -beta-synthase are ubiquitously distributed in human fallopian tube epithelium and that H2S signalling relaxes the spontaneous contraction of the human oviduct.	Hydrogen Sulfide	150-153	cystathionine beta-synthase	Homo sapiens	48-76
24730561-2	2014	METHODS: To investigate the phenotypic and epigenetic consequences of altered methionine metabolism in this disease, we studied the effects of 4-week intragastric EtOH feeding with and without the methyl donor betaine in cystathionine beta synthase (CbetaS) heterozygous C57BL/6J mice.	Betaine	210-217	cystathionine beta-synthase	Homo sapiens	221-248
23991749-7	2014	Moreover, recent studies demonstrate that colorectal cancer cells up-regulate the H2 S-producing enzyme cystathionine beta-synthase (CBS), and utilize its product, H2 S, as a metabolic fuel and tumour-cell survival factor; pharmacological CBS inhibition or genetic CBS silencing suppresses cancer cell bioenergetics and suppresses cell proliferation and cell chemotaxis.	h2 s	82-86	cystathionine beta-synthase	Homo sapiens	104-131
24706765-0	2014	Mg2+-dependent interactions of ATP with the cystathionine-beta-synthase (CBS) domains of a magnesium transporter.	magnesium ion	0-4	cystathionine beta-synthase	Homo sapiens	44-71
24706765-0	2014	Mg2+-dependent interactions of ATP with the cystathionine-beta-synthase (CBS) domains of a magnesium transporter.	Adenosine Triphosphate	31-34	cystathionine beta-synthase	Homo sapiens	44-71
24706765-3	2014	Here, we show the functional importance of the commonly conserved cystathionine-beta-synthase (CBS) domains and reveal their unique binding ability to ATP.	Adenosine Triphosphate	151-154	cystathionine beta-synthase	Homo sapiens	66-93
24534463-0	2014	Homocysteine contribution to DNA damage in cystathionine beta-synthase-deficient patients.	Homocysteine	0-12	cystathionine beta-synthase	Homo sapiens	43-70
24534463-1	2014	High blood levels of homocysteine (Hcy) are found in patients affected by homocystinuria, a genetic disorder caused by deficiency of cystathionine beta-synthase (CBS) activity, as well as in nutritional deficiencies (vitamin B12 or folate) and in abnormal renal function.	Homocysteine	21-33	cystathionine beta-synthase	Homo sapiens	133-160
24534463-1	2014	High blood levels of homocysteine (Hcy) are found in patients affected by homocystinuria, a genetic disorder caused by deficiency of cystathionine beta-synthase (CBS) activity, as well as in nutritional deficiencies (vitamin B12 or folate) and in abnormal renal function.	Homocysteine	21-33	cystathionine beta-synthase	Homo sapiens	162-165
24534463-1	2014	High blood levels of homocysteine (Hcy) are found in patients affected by homocystinuria, a genetic disorder caused by deficiency of cystathionine beta-synthase (CBS) activity, as well as in nutritional deficiencies (vitamin B12 or folate) and in abnormal renal function.	Homocysteine	35-38	cystathionine beta-synthase	Homo sapiens	133-160
24534463-1	2014	High blood levels of homocysteine (Hcy) are found in patients affected by homocystinuria, a genetic disorder caused by deficiency of cystathionine beta-synthase (CBS) activity, as well as in nutritional deficiencies (vitamin B12 or folate) and in abnormal renal function.	Homocysteine	35-38	cystathionine beta-synthase	Homo sapiens	162-165
24733942-2	2014	These reactive sulfur species were biosynthesized by two major sulfurtransferases: cystathionine beta-synthase and cystathionine gamma-lyase.	reactive sulfur	6-21	cystathionine beta-synthase	Homo sapiens	83-110
23991749-7	2014	Moreover, recent studies demonstrate that colorectal cancer cells up-regulate the H2 S-producing enzyme cystathionine beta-synthase (CBS), and utilize its product, H2 S, as a metabolic fuel and tumour-cell survival factor; pharmacological CBS inhibition or genetic CBS silencing suppresses cancer cell bioenergetics and suppresses cell proliferation and cell chemotaxis.	h2 s	164-168	cystathionine beta-synthase	Homo sapiens	104-131
23991830-4	2014	H2 S is produced by cystathionine gamma-lyase (CSE), cystathionine beta-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST).	Hydrogen Sulfide	0-4	cystathionine beta-synthase	Homo sapiens	53-80
23991830-4	2014	H2 S is produced by cystathionine gamma-lyase (CSE), cystathionine beta-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST).	Hydrogen Sulfide	0-4	cystathionine beta-synthase	Homo sapiens	82-85
23991830-7	2014	In specialized conditions (calcium overload in vascular smooth muscle, colon cancer cells), CSE and CBS can also associate with the mitochondria; H2 S produced by these enzymes, serves as an endogenous stimulator of cellular bioenergetics.	Calcium	27-34	cystathionine beta-synthase	Homo sapiens	100-103
23991830-7	2014	In specialized conditions (calcium overload in vascular smooth muscle, colon cancer cells), CSE and CBS can also associate with the mitochondria; H2 S produced by these enzymes, serves as an endogenous stimulator of cellular bioenergetics.	Hydrogen Sulfide	146-150	cystathionine beta-synthase	Homo sapiens	100-103
24491853-4	2014	In the human body, H2S production is predominantly catalyzed by cystathionine-beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	19-22	cystathionine beta-synthase	Homo sapiens	64-91
24515102-1	2014	The hexa-coordinate heme in the H2S-generating human enzyme cystathionine beta-synthase (CBS) acts as a redox-sensitive regulator that impairs CBS activity upon binding of NO( ) or CO at the reduced iron.	Heme	20-24	cystathionine beta-synthase	Homo sapiens	60-87
24515102-1	2014	The hexa-coordinate heme in the H2S-generating human enzyme cystathionine beta-synthase (CBS) acts as a redox-sensitive regulator that impairs CBS activity upon binding of NO( ) or CO at the reduced iron.	Heme	20-24	cystathionine beta-synthase	Homo sapiens	89-92
24515102-1	2014	The hexa-coordinate heme in the H2S-generating human enzyme cystathionine beta-synthase (CBS) acts as a redox-sensitive regulator that impairs CBS activity upon binding of NO( ) or CO at the reduced iron.	Heme	20-24	cystathionine beta-synthase	Homo sapiens	143-146
24515102-1	2014	The hexa-coordinate heme in the H2S-generating human enzyme cystathionine beta-synthase (CBS) acts as a redox-sensitive regulator that impairs CBS activity upon binding of NO( ) or CO at the reduced iron.	Hydrogen Sulfide	32-35	cystathionine beta-synthase	Homo sapiens	60-87
24515102-1	2014	The hexa-coordinate heme in the H2S-generating human enzyme cystathionine beta-synthase (CBS) acts as a redox-sensitive regulator that impairs CBS activity upon binding of NO( ) or CO at the reduced iron.	Hydrogen Sulfide	32-35	cystathionine beta-synthase	Homo sapiens	89-92
24515102-1	2014	The hexa-coordinate heme in the H2S-generating human enzyme cystathionine beta-synthase (CBS) acts as a redox-sensitive regulator that impairs CBS activity upon binding of NO( ) or CO at the reduced iron.	Hydrogen Sulfide	32-35	cystathionine beta-synthase	Homo sapiens	143-146
24515102-1	2014	The hexa-coordinate heme in the H2S-generating human enzyme cystathionine beta-synthase (CBS) acts as a redox-sensitive regulator that impairs CBS activity upon binding of NO( ) or CO at the reduced iron.	Iron	199-203	cystathionine beta-synthase	Homo sapiens	60-87
24515102-1	2014	The hexa-coordinate heme in the H2S-generating human enzyme cystathionine beta-synthase (CBS) acts as a redox-sensitive regulator that impairs CBS activity upon binding of NO( ) or CO at the reduced iron.	Iron	199-203	cystathionine beta-synthase	Homo sapiens	89-92
24515102-1	2014	The hexa-coordinate heme in the H2S-generating human enzyme cystathionine beta-synthase (CBS) acts as a redox-sensitive regulator that impairs CBS activity upon binding of NO( ) or CO at the reduced iron.	Iron	199-203	cystathionine beta-synthase	Homo sapiens	143-146
24515102-2	2014	Despite the proposed physiological relevance of this inhibitory mechanism, unlike CO, NO( ) was reported to bind at the CBS heme with very low affinity (Kd = 30-281 mum).	Heme	124-128	cystathionine beta-synthase	Homo sapiens	120-123
24515102-7	2014	The novel findings reported here shed new light on CBS regulation by NO( ) and its possible (patho)physiological relevance, enforcing the growing evidence for an interplay among the gasotransmitters NO( ), CO, and H2S in cell signaling.	Carbon Monoxide	206-208	cystathionine beta-synthase	Homo sapiens	51-54
24515102-7	2014	The novel findings reported here shed new light on CBS regulation by NO( ) and its possible (patho)physiological relevance, enforcing the growing evidence for an interplay among the gasotransmitters NO( ), CO, and H2S in cell signaling.	Hydrogen Sulfide	214-217	cystathionine beta-synthase	Homo sapiens	51-54
24598918-1	2014	Cystathionine beta-synthase (CBS; EC 4.2.1.22) catalyzes the condensation of homocysteine and serine to form cystathionine, with the release of water.	Homocysteine	77-89	cystathionine beta-synthase	Homo sapiens	0-27
24598918-1	2014	Cystathionine beta-synthase (CBS; EC 4.2.1.22) catalyzes the condensation of homocysteine and serine to form cystathionine, with the release of water.	Homocysteine	77-89	cystathionine beta-synthase	Homo sapiens	29-32
24598918-4	2014	Here, the purification and preliminary crystallographic analysis of the catalytic core of CBS from Saccharomyces cerevisiae (ScCBS) is described which, in contrast to other eukaryotic CBSs, lacks the N-terminal haem-binding domain and is considered to be a useful model for investigation of the pyridoxal-5"-phosphate-mediated reactions of human CBS (hCBS).	Pyridoxal Phosphate	295-317	cystathionine beta-synthase	Homo sapiens	90-93
24598918-4	2014	Here, the purification and preliminary crystallographic analysis of the catalytic core of CBS from Saccharomyces cerevisiae (ScCBS) is described which, in contrast to other eukaryotic CBSs, lacks the N-terminal haem-binding domain and is considered to be a useful model for investigation of the pyridoxal-5"-phosphate-mediated reactions of human CBS (hCBS).	Pyridoxal Phosphate	295-317	cystathionine beta-synthase	Homo sapiens	127-130
24598918-1	2014	Cystathionine beta-synthase (CBS; EC 4.2.1.22) catalyzes the condensation of homocysteine and serine to form cystathionine, with the release of water.	Serine	94-100	cystathionine beta-synthase	Homo sapiens	0-27
24598918-1	2014	Cystathionine beta-synthase (CBS; EC 4.2.1.22) catalyzes the condensation of homocysteine and serine to form cystathionine, with the release of water.	Serine	94-100	cystathionine beta-synthase	Homo sapiens	29-32
24598918-1	2014	Cystathionine beta-synthase (CBS; EC 4.2.1.22) catalyzes the condensation of homocysteine and serine to form cystathionine, with the release of water.	Cystathionine	109-122	cystathionine beta-synthase	Homo sapiens	0-27
24598918-4	2014	Here, the purification and preliminary crystallographic analysis of the catalytic core of CBS from Saccharomyces cerevisiae (ScCBS) is described which, in contrast to other eukaryotic CBSs, lacks the N-terminal haem-binding domain and is considered to be a useful model for investigation of the pyridoxal-5"-phosphate-mediated reactions of human CBS (hCBS).	hcbs	351-355	cystathionine beta-synthase	Homo sapiens	90-93
24598918-4	2014	Here, the purification and preliminary crystallographic analysis of the catalytic core of CBS from Saccharomyces cerevisiae (ScCBS) is described which, in contrast to other eukaryotic CBSs, lacks the N-terminal haem-binding domain and is considered to be a useful model for investigation of the pyridoxal-5"-phosphate-mediated reactions of human CBS (hCBS).	hcbs	351-355	cystathionine beta-synthase	Homo sapiens	127-130
24598918-1	2014	Cystathionine beta-synthase (CBS; EC 4.2.1.22) catalyzes the condensation of homocysteine and serine to form cystathionine, with the release of water.	Cystathionine	109-122	cystathionine beta-synthase	Homo sapiens	29-32
24598918-1	2014	Cystathionine beta-synthase (CBS; EC 4.2.1.22) catalyzes the condensation of homocysteine and serine to form cystathionine, with the release of water.	Water	144-149	cystathionine beta-synthase	Homo sapiens	0-27
24598918-1	2014	Cystathionine beta-synthase (CBS; EC 4.2.1.22) catalyzes the condensation of homocysteine and serine to form cystathionine, with the release of water.	Water	144-149	cystathionine beta-synthase	Homo sapiens	29-32
24169224-10	2014	CONCLUSION: In patients with CVT, plasma total homocysteine measurement as part of the etiologic work up may reveal severe hyperhomocysteinemia due to CBS or remethylation defects that require specific treatment and management including perhaps protein-restricted diet and/or vitamin therapy for life.	Homocysteine	47-59	cystathionine beta-synthase	Homo sapiens	151-154
23974653-0	2014	Reduced response of Cystathionine Beta-Synthase (CBS) to S-Adenosylmethionine (SAM): Identification and functional analysis of CBS gene mutations in Homocystinuria patients.	S-Adenosylmethionine	57-77	cystathionine beta-synthase	Homo sapiens	20-47
23974653-0	2014	Reduced response of Cystathionine Beta-Synthase (CBS) to S-Adenosylmethionine (SAM): Identification and functional analysis of CBS gene mutations in Homocystinuria patients.	S-Adenosylmethionine	57-77	cystathionine beta-synthase	Homo sapiens	49-52
23974653-0	2014	Reduced response of Cystathionine Beta-Synthase (CBS) to S-Adenosylmethionine (SAM): Identification and functional analysis of CBS gene mutations in Homocystinuria patients.	S-Adenosylmethionine	79-82	cystathionine beta-synthase	Homo sapiens	20-47
23974653-0	2014	Reduced response of Cystathionine Beta-Synthase (CBS) to S-Adenosylmethionine (SAM): Identification and functional analysis of CBS gene mutations in Homocystinuria patients.	S-Adenosylmethionine	79-82	cystathionine beta-synthase	Homo sapiens	49-52
23974653-0	2014	Reduced response of Cystathionine Beta-Synthase (CBS) to S-Adenosylmethionine (SAM): Identification and functional analysis of CBS gene mutations in Homocystinuria patients.	S-Adenosylmethionine	79-82	cystathionine beta-synthase	Homo sapiens	127-130
24559276-3	2014	The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism.	Folic Acid	174-180	cystathionine beta-synthase	Homo sapiens	110-137
24559276-3	2014	The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism.	Folic Acid	174-180	cystathionine beta-synthase	Homo sapiens	139-142
24559276-3	2014	The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism.	Homocysteine	185-188	cystathionine beta-synthase	Homo sapiens	110-137
24559276-3	2014	The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism.	Homocysteine	185-188	cystathionine beta-synthase	Homo sapiens	139-142
24211323-1	2014	Classical homocystinuria is the most commonly inherited disorder of sulfur metabolism, caused by the genetic alterations in human cystathionine beta-synthase (CBS) gene.	Sulfur	68-74	cystathionine beta-synthase	Homo sapiens	130-157
24211323-1	2014	Classical homocystinuria is the most commonly inherited disorder of sulfur metabolism, caused by the genetic alterations in human cystathionine beta-synthase (CBS) gene.	Sulfur	68-74	cystathionine beta-synthase	Homo sapiens	159-162
25005183-9	2014	Homocysteine is a precursor of hydrogen sulfide (H2S) which is formed by transulfuration process catalyzed by the enzymes, cystathionine beta-synthase and cystathionine gamma-lyase.	Homocysteine	0-12	cystathionine beta-synthase	Homo sapiens	123-150
24416422-3	2014	In this study, we have identified human cystathionine ss-synthase (CBS) as a new player in nitrite reduction with implications for the nitrite-dependent control of H2S production.	Nitrites	91-98	cystathionine beta-synthase	Homo sapiens	67-70
24416422-3	2014	In this study, we have identified human cystathionine ss-synthase (CBS) as a new player in nitrite reduction with implications for the nitrite-dependent control of H2S production.	Nitrites	135-142	cystathionine beta-synthase	Homo sapiens	67-70
24416422-3	2014	In this study, we have identified human cystathionine ss-synthase (CBS) as a new player in nitrite reduction with implications for the nitrite-dependent control of H2S production.	Hydrogen Sulfide	164-167	cystathionine beta-synthase	Homo sapiens	67-70
24416422-4	2014	This novel activity of CBS exploits the catalytic property of its unusual heme cofactor to reduce nitrite and generate NO.	Heme	74-78	cystathionine beta-synthase	Homo sapiens	23-26
24416422-4	2014	This novel activity of CBS exploits the catalytic property of its unusual heme cofactor to reduce nitrite and generate NO.	Nitrites	98-105	cystathionine beta-synthase	Homo sapiens	23-26
24416422-5	2014	Evidence for the possible physiological relevance of this reaction is provided by the formation of ferrous-nitrosyl (Fe(II)-NO) CBS in the presence of NADPH, the human diflavin methionine synthase reductase (MSR) and nitrite.	ferrous-nitrosyl	99-115	cystathionine beta-synthase	Homo sapiens	128-131
24416422-5	2014	Evidence for the possible physiological relevance of this reaction is provided by the formation of ferrous-nitrosyl (Fe(II)-NO) CBS in the presence of NADPH, the human diflavin methionine synthase reductase (MSR) and nitrite.	fe(ii)-no	117-126	cystathionine beta-synthase	Homo sapiens	128-131
24416422-5	2014	Evidence for the possible physiological relevance of this reaction is provided by the formation of ferrous-nitrosyl (Fe(II)-NO) CBS in the presence of NADPH, the human diflavin methionine synthase reductase (MSR) and nitrite.	NADP	151-156	cystathionine beta-synthase	Homo sapiens	128-131
24416422-5	2014	Evidence for the possible physiological relevance of this reaction is provided by the formation of ferrous-nitrosyl (Fe(II)-NO) CBS in the presence of NADPH, the human diflavin methionine synthase reductase (MSR) and nitrite.	Nitrites	217-224	cystathionine beta-synthase	Homo sapiens	128-131
24416422-6	2014	Formation of Fe(II)-NO CBS via its nitrite reductase activity inhibits CBS, providing an avenue for regulating biogenesis of H2S and cysteine, the limiting reagent for synthesis of glutathione, a major antioxidant.	fe(ii)-no	13-22	cystathionine beta-synthase	Homo sapiens	23-26
24416422-6	2014	Formation of Fe(II)-NO CBS via its nitrite reductase activity inhibits CBS, providing an avenue for regulating biogenesis of H2S and cysteine, the limiting reagent for synthesis of glutathione, a major antioxidant.	fe(ii)-no	13-22	cystathionine beta-synthase	Homo sapiens	71-74
24416422-6	2014	Formation of Fe(II)-NO CBS via its nitrite reductase activity inhibits CBS, providing an avenue for regulating biogenesis of H2S and cysteine, the limiting reagent for synthesis of glutathione, a major antioxidant.	Hydrogen Sulfide	125-128	cystathionine beta-synthase	Homo sapiens	23-26
24416422-6	2014	Formation of Fe(II)-NO CBS via its nitrite reductase activity inhibits CBS, providing an avenue for regulating biogenesis of H2S and cysteine, the limiting reagent for synthesis of glutathione, a major antioxidant.	Hydrogen Sulfide	125-128	cystathionine beta-synthase	Homo sapiens	71-74
24416422-6	2014	Formation of Fe(II)-NO CBS via its nitrite reductase activity inhibits CBS, providing an avenue for regulating biogenesis of H2S and cysteine, the limiting reagent for synthesis of glutathione, a major antioxidant.	Cysteine	133-141	cystathionine beta-synthase	Homo sapiens	23-26
24416422-6	2014	Formation of Fe(II)-NO CBS via its nitrite reductase activity inhibits CBS, providing an avenue for regulating biogenesis of H2S and cysteine, the limiting reagent for synthesis of glutathione, a major antioxidant.	Cysteine	133-141	cystathionine beta-synthase	Homo sapiens	71-74
24416422-6	2014	Formation of Fe(II)-NO CBS via its nitrite reductase activity inhibits CBS, providing an avenue for regulating biogenesis of H2S and cysteine, the limiting reagent for synthesis of glutathione, a major antioxidant.	Glutathione	181-192	cystathionine beta-synthase	Homo sapiens	23-26
24416422-6	2014	Formation of Fe(II)-NO CBS via its nitrite reductase activity inhibits CBS, providing an avenue for regulating biogenesis of H2S and cysteine, the limiting reagent for synthesis of glutathione, a major antioxidant.	Glutathione	181-192	cystathionine beta-synthase	Homo sapiens	71-74
24416422-8	2014	The participation of a regulatory heme cofactor in CBS in nitrite reduction is unexpected and expands the repertoire of proteins that can liberate NO from the intracellular nitrite pool.	Heme	34-38	cystathionine beta-synthase	Homo sapiens	51-54
24416422-8	2014	The participation of a regulatory heme cofactor in CBS in nitrite reduction is unexpected and expands the repertoire of proteins that can liberate NO from the intracellular nitrite pool.	Nitrites	58-65	cystathionine beta-synthase	Homo sapiens	51-54
24416422-8	2014	The participation of a regulatory heme cofactor in CBS in nitrite reduction is unexpected and expands the repertoire of proteins that can liberate NO from the intracellular nitrite pool.	Nitrites	173-180	cystathionine beta-synthase	Homo sapiens	51-54
25005183-9	2014	Homocysteine is a precursor of hydrogen sulfide (H2S) which is formed by transulfuration process catalyzed by the enzymes, cystathionine beta-synthase and cystathionine gamma-lyase.	Hydrogen Sulfide	31-47	cystathionine beta-synthase	Homo sapiens	123-150
25005183-9	2014	Homocysteine is a precursor of hydrogen sulfide (H2S) which is formed by transulfuration process catalyzed by the enzymes, cystathionine beta-synthase and cystathionine gamma-lyase.	Hydrogen Sulfide	49-52	cystathionine beta-synthase	Homo sapiens	123-150
24239876-3	2014	The endogenous level of H2S in the brain is significantly higher than that in peripheral tissues, and is mainly formed by cystathionine beta-synthase (CBS) in astrocytes and released in response to neuronal excitation.	Hydrogen Sulfide	24-27	cystathionine beta-synthase	Homo sapiens	122-149
24213681-2	2013	Screening of 21,599 agents identified several potent inhibitors of cystathionine beta-synthase and cystathionine gamma-lyase, the two key enzymes generating H2S in mammals, with IC50 values in the low two-digit micromolar range.	Hydrogen Sulfide	157-160	cystathionine beta-synthase	Homo sapiens	67-94
24320595-8	2013	Replication in an independent GWAS dataset of phospholipids (Demirkan et al., PLoS Genetics, 2012) identified two novel loci supported by additional literature evidence: GPAM (Glycerol-3 phosphate acyltransferase) and CBS (Cystathionine beta-synthase).	Phospholipids	46-59	cystathionine beta-synthase	Homo sapiens	218-221
24320595-8	2013	Replication in an independent GWAS dataset of phospholipids (Demirkan et al., PLoS Genetics, 2012) identified two novel loci supported by additional literature evidence: GPAM (Glycerol-3 phosphate acyltransferase) and CBS (Cystathionine beta-synthase).	Phospholipids	46-59	cystathionine beta-synthase	Homo sapiens	223-250
24161944-4	2013	In contrast with initial assumptions, it is now well documented that CBS motifs and/or Bateman modules may suffer conformational changes upon binding of adenosine derivatives, metal ions or nucleic acids.	Adenosine	153-162	cystathionine beta-synthase	Homo sapiens	69-72
24161944-4	2013	In contrast with initial assumptions, it is now well documented that CBS motifs and/or Bateman modules may suffer conformational changes upon binding of adenosine derivatives, metal ions or nucleic acids.	Metals	176-181	cystathionine beta-synthase	Homo sapiens	69-72
24236104-4	2013	METHODS/PRINCIPAL FINDINGS: Using patient tissue microarray (TMA), in vitro and in vivo studies we report a role of of cystathionine-beta-synthase (CBS), a sulfur metabolism enzyme in ovarian carcinoma.	Sulfur	156-162	cystathionine beta-synthase	Homo sapiens	119-146
23981774-1	2013	Cystathionine beta-synthase (CBS) is a pyridoxal 5"-phosphate (PLP)-dependent enzyme that catalyzes the condensation of homocysteine with serine to generate cystathionine.	Homocysteine	120-132	cystathionine beta-synthase	Homo sapiens	0-27
23981774-1	2013	Cystathionine beta-synthase (CBS) is a pyridoxal 5"-phosphate (PLP)-dependent enzyme that catalyzes the condensation of homocysteine with serine to generate cystathionine.	Homocysteine	120-132	cystathionine beta-synthase	Homo sapiens	29-32
23981774-1	2013	Cystathionine beta-synthase (CBS) is a pyridoxal 5"-phosphate (PLP)-dependent enzyme that catalyzes the condensation of homocysteine with serine to generate cystathionine.	Serine	138-144	cystathionine beta-synthase	Homo sapiens	0-27
23981774-1	2013	Cystathionine beta-synthase (CBS) is a pyridoxal 5"-phosphate (PLP)-dependent enzyme that catalyzes the condensation of homocysteine with serine to generate cystathionine.	Serine	138-144	cystathionine beta-synthase	Homo sapiens	29-32
23981774-1	2013	Cystathionine beta-synthase (CBS) is a pyridoxal 5"-phosphate (PLP)-dependent enzyme that catalyzes the condensation of homocysteine with serine to generate cystathionine.	Cystathionine	157-170	cystathionine beta-synthase	Homo sapiens	0-27
23981774-1	2013	Cystathionine beta-synthase (CBS) is a pyridoxal 5"-phosphate (PLP)-dependent enzyme that catalyzes the condensation of homocysteine with serine to generate cystathionine.	Cystathionine	157-170	cystathionine beta-synthase	Homo sapiens	29-32
23981774-3	2013	Here, we characterized a novel CBS mutation (c.260C&gt;A (p.T87N)) and a previously reported variant (c.700G&gt;A (p.D234N)) found in Venezuelan homocystinuric patients, one nonresponsive and one responsive to vitamin B6.	Vitamin B 6	210-220	cystathionine beta-synthase	Homo sapiens	31-34
24236104-7	2013	Silencing CBS in a cisplatin resistant orthotopic model in vivo by nanoliposomal delivery of CBS siRNA inhibits tumor growth, reduces nodule formation and sensitizes ovarian cancer cells to cisplatin.	Cisplatin	190-199	cystathionine beta-synthase	Homo sapiens	93-96
24236104-9	2013	Furthermore, CBS also regulates bioenergetics of ovarian cancer cells by regulating mitochondrial ROS production, oxygen consumption and ATP generation.	ros	98-101	cystathionine beta-synthase	Homo sapiens	13-16
24236104-9	2013	Furthermore, CBS also regulates bioenergetics of ovarian cancer cells by regulating mitochondrial ROS production, oxygen consumption and ATP generation.	Oxygen	114-120	cystathionine beta-synthase	Homo sapiens	13-16
24236104-9	2013	Furthermore, CBS also regulates bioenergetics of ovarian cancer cells by regulating mitochondrial ROS production, oxygen consumption and ATP generation.	Adenosine Triphosphate	137-140	cystathionine beta-synthase	Homo sapiens	13-16
24236104-4	2013	METHODS/PRINCIPAL FINDINGS: Using patient tissue microarray (TMA), in vitro and in vivo studies we report a role of of cystathionine-beta-synthase (CBS), a sulfur metabolism enzyme in ovarian carcinoma.	Sulfur	156-162	cystathionine beta-synthase	Homo sapiens	148-151
24236104-5	2013	We report here that the expression of cystathionine-beta-synthase (CBS), a sulfur metabolism enzyme, is common in primary serous ovarian carcinoma.	Sulfur	75-81	cystathionine beta-synthase	Homo sapiens	38-65
24236104-5	2013	We report here that the expression of cystathionine-beta-synthase (CBS), a sulfur metabolism enzyme, is common in primary serous ovarian carcinoma.	Sulfur	75-81	cystathionine beta-synthase	Homo sapiens	67-70
24236104-6	2013	The in vitro effects of CBS silencing can be reversed by exogenous supplementation with the GSH and H2S producing chemical Na2S.	Glutathione	92-95	cystathionine beta-synthase	Homo sapiens	24-27
24236104-6	2013	The in vitro effects of CBS silencing can be reversed by exogenous supplementation with the GSH and H2S producing chemical Na2S.	Hydrogen Sulfide	100-103	cystathionine beta-synthase	Homo sapiens	24-27
24236104-6	2013	The in vitro effects of CBS silencing can be reversed by exogenous supplementation with the GSH and H2S producing chemical Na2S.	sodium sulfide	123-127	cystathionine beta-synthase	Homo sapiens	24-27
24236104-7	2013	Silencing CBS in a cisplatin resistant orthotopic model in vivo by nanoliposomal delivery of CBS siRNA inhibits tumor growth, reduces nodule formation and sensitizes ovarian cancer cells to cisplatin.	Cisplatin	19-28	cystathionine beta-synthase	Homo sapiens	10-13
24236104-7	2013	Silencing CBS in a cisplatin resistant orthotopic model in vivo by nanoliposomal delivery of CBS siRNA inhibits tumor growth, reduces nodule formation and sensitizes ovarian cancer cells to cisplatin.	Cisplatin	19-28	cystathionine beta-synthase	Homo sapiens	93-96
24236104-7	2013	Silencing CBS in a cisplatin resistant orthotopic model in vivo by nanoliposomal delivery of CBS siRNA inhibits tumor growth, reduces nodule formation and sensitizes ovarian cancer cells to cisplatin.	Cisplatin	190-199	cystathionine beta-synthase	Homo sapiens	10-13
24117256-1	2013	Hydrogen sulfide (H2S) is synthesized from L-cysteine by cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), and is enzymatically metabolized in mitochondria by sulfide:quinone oxidoreductase (SQR).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	57-84
24117256-1	2013	Hydrogen sulfide (H2S) is synthesized from L-cysteine by cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), and is enzymatically metabolized in mitochondria by sulfide:quinone oxidoreductase (SQR).	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	57-84
24117256-1	2013	Hydrogen sulfide (H2S) is synthesized from L-cysteine by cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), and is enzymatically metabolized in mitochondria by sulfide:quinone oxidoreductase (SQR).	Cysteine	43-53	cystathionine beta-synthase	Homo sapiens	57-84
24117256-1	2013	Hydrogen sulfide (H2S) is synthesized from L-cysteine by cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), and is enzymatically metabolized in mitochondria by sulfide:quinone oxidoreductase (SQR).	Sulfides	9-16	cystathionine beta-synthase	Homo sapiens	57-84
23954866-0	2013	Gene-environment and gene-gene interactions of specific MTHFR, MTR and CBS gene variants in relation to homocysteine in black South Africans.	Homocysteine	104-116	cystathionine beta-synthase	Homo sapiens	71-74
24043838-1	2013	Cystathionine beta-synthase (CBS) controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H2S.	Sulfur	55-61	cystathionine beta-synthase	Homo sapiens	0-27
23882023-7	2013	We found significant associations with LDL-C and total-cholesterol levels for a synonymous SNP (rs234706) in the cystathionine beta-synthase (CBS) gene (p = 1 x 10(-5) and adjusted-p = 0.013, respectively).	Cholesterol	55-66	cystathionine beta-synthase	Homo sapiens	113-140
23882023-7	2013	We found significant associations with LDL-C and total-cholesterol levels for a synonymous SNP (rs234706) in the cystathionine beta-synthase (CBS) gene (p = 1 x 10(-5) and adjusted-p = 0.013, respectively).	Cholesterol	55-66	cystathionine beta-synthase	Homo sapiens	142-145
24036365-3	2013	H2S is produced from L-cysteine by enzymes such as cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) along with cysteine aminotransferase (CAT).	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	51-78
24036365-3	2013	H2S is produced from L-cysteine by enzymes such as cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST) along with cysteine aminotransferase (CAT).	Cysteine	21-31	cystathionine beta-synthase	Homo sapiens	51-78
23934999-6	2013	Some of these B6-sensitive substitutions also had altered sensitivity to limiting heme, another CBS cofactor.	Heme	82-86	cystathionine beta-synthase	Homo sapiens	96-99
23778007-2	2013	The majority of missense mutations of cystathionine beta-synthase (CBS) domains found in PCS impair the binding activity of PRKAG2 to adenosine derivatives, and therefore lead to PRKAG2 function impairment and AMPK activity alteration, resulting in a familial syndrome of ventricular preexcitation, conduction defects, and cardiac hypertrophy.	Adenosine	134-143	cystathionine beta-synthase	Homo sapiens	38-65
24043838-1	2013	Cystathionine beta-synthase (CBS) controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H2S.	Sulfur	55-61	cystathionine beta-synthase	Homo sapiens	29-32
24043838-1	2013	Cystathionine beta-synthase (CBS) controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H2S.	Methionine	67-77	cystathionine beta-synthase	Homo sapiens	0-27
24043838-1	2013	Cystathionine beta-synthase (CBS) controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H2S.	Methionine	67-77	cystathionine beta-synthase	Homo sapiens	29-32
24043838-1	2013	Cystathionine beta-synthase (CBS) controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H2S.	Cysteine	81-89	cystathionine beta-synthase	Homo sapiens	0-27
24043838-1	2013	Cystathionine beta-synthase (CBS) controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H2S.	Cysteine	81-89	cystathionine beta-synthase	Homo sapiens	29-32
24043838-1	2013	Cystathionine beta-synthase (CBS) controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H2S.	Glutathione	106-117	cystathionine beta-synthase	Homo sapiens	0-27
24043838-1	2013	Cystathionine beta-synthase (CBS) controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H2S.	Glutathione	106-117	cystathionine beta-synthase	Homo sapiens	29-32
24043838-1	2013	Cystathionine beta-synthase (CBS) controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H2S.	Taurine	119-126	cystathionine beta-synthase	Homo sapiens	0-27
24043838-1	2013	Cystathionine beta-synthase (CBS) controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H2S.	Taurine	119-126	cystathionine beta-synthase	Homo sapiens	29-32
24043838-1	2013	Cystathionine beta-synthase (CBS) controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H2S.	Hydrogen Sulfide	132-135	cystathionine beta-synthase	Homo sapiens	0-27
24043838-1	2013	Cystathionine beta-synthase (CBS) controls the flux of sulfur from methionine to cysteine, a precursor of glutathione, taurine, and H2S.	Hydrogen Sulfide	132-135	cystathionine beta-synthase	Homo sapiens	29-32
24043838-2	2013	CBS condenses serine and homocysteine to cystathionine with the help of three cofactors, heme, pyridoxal-5"-phosphate, and S-adenosyl-l-methionine.	Serine	14-20	cystathionine beta-synthase	Homo sapiens	0-3
24043838-2	2013	CBS condenses serine and homocysteine to cystathionine with the help of three cofactors, heme, pyridoxal-5"-phosphate, and S-adenosyl-l-methionine.	Homocysteine	25-37	cystathionine beta-synthase	Homo sapiens	0-3
24043838-2	2013	CBS condenses serine and homocysteine to cystathionine with the help of three cofactors, heme, pyridoxal-5"-phosphate, and S-adenosyl-l-methionine.	Cystathionine	41-54	cystathionine beta-synthase	Homo sapiens	0-3
24043838-2	2013	CBS condenses serine and homocysteine to cystathionine with the help of three cofactors, heme, pyridoxal-5"-phosphate, and S-adenosyl-l-methionine.	Heme	89-93	cystathionine beta-synthase	Homo sapiens	0-3
24043838-2	2013	CBS condenses serine and homocysteine to cystathionine with the help of three cofactors, heme, pyridoxal-5"-phosphate, and S-adenosyl-l-methionine.	Pyridoxal Phosphate	95-117	cystathionine beta-synthase	Homo sapiens	0-3
24043838-2	2013	CBS condenses serine and homocysteine to cystathionine with the help of three cofactors, heme, pyridoxal-5"-phosphate, and S-adenosyl-l-methionine.	S-Adenosylmethionine	123-146	cystathionine beta-synthase	Homo sapiens	0-3
24043838-6	2013	The absence of large conformational changes and the crystal structure of the partially activated pathogenic D444N mutant suggest that the rotation of CBS motifs and relaxation of loops delineating the entrance to the catalytic site represent the most likely molecular mechanism of CBS activation by S-adenosyl-l-methionine.	S-Adenosylmethionine	299-322	cystathionine beta-synthase	Homo sapiens	150-153
24043838-8	2013	Because of its central role in transsulfuration, redox status, and H2S biogenesis, CBS represents a very attractive therapeutic target.	Hydrogen Sulfide	67-70	cystathionine beta-synthase	Homo sapiens	83-86
23745510-4	2013	Molecular TPM imaging with SHS-M2 in astrocytes revealed that there is a correlation between the ratiometric analysis and expression levels of cystathionine beta-synthase (CBS), the major enzyme that catalyzes H2S production.	Deuterium	210-213	cystathionine beta-synthase	Homo sapiens	143-170
23728586-7	2013	L-cysteine (L-Cys, a substrate of CBS, CSE and MPST) elicited relaxation in a dose-dependent manner on human bladder strips pre-contracted by acetylcholine chloride.	Cysteine	0-10	cystathionine beta-synthase	Homo sapiens	34-37
23728586-7	2013	L-cysteine (L-Cys, a substrate of CBS, CSE and MPST) elicited relaxation in a dose-dependent manner on human bladder strips pre-contracted by acetylcholine chloride.	Cysteine	12-17	cystathionine beta-synthase	Homo sapiens	34-37
23728586-7	2013	L-cysteine (L-Cys, a substrate of CBS, CSE and MPST) elicited relaxation in a dose-dependent manner on human bladder strips pre-contracted by acetylcholine chloride.	Acetylcholine	142-164	cystathionine beta-synthase	Homo sapiens	34-37
23728586-8	2013	This effect could be diminished by the ATP-sensitive potassium ion (KATP) channel blocker glibenclamide (GLB), the CSE inhibitor DL-propargylglycine (PPG) and the CBS inhibitor hydroxylamine (HA).	Hydroxylamine	177-190	cystathionine beta-synthase	Homo sapiens	163-166
23702336-4	2013	As we found that the expression levels of the two main H2S producing enzymes, cystathionine beta synthase and cystathionine gamma lyase, were lower in WS cells compared to normal, we investigated the effect of administration of H2S as NaHS (50muM).	Hydrogen Sulfide	55-58	cystathionine beta-synthase	Homo sapiens	78-105
23882260-3	2013	H2S is produced by enzymes from l-cysteine; cystathionine beta-synthase, cystathionine gamma-lyase, and 3-mercaptopyruvate sulfurtransferase (3MST) along with cysteine aminotransferase.	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	44-71
23882260-3	2013	H2S is produced by enzymes from l-cysteine; cystathionine beta-synthase, cystathionine gamma-lyase, and 3-mercaptopyruvate sulfurtransferase (3MST) along with cysteine aminotransferase.	Cysteine	32-42	cystathionine beta-synthase	Homo sapiens	44-71
24019484-2	2013	Alternatively, by the transulfuration pathway, homocysteine is transformed to hydrogen sulphide (H2S), through multiple steps involving cystathionine beta-synthase and cystathionine gamma-lyase.	Homocysteine	47-59	cystathionine beta-synthase	Homo sapiens	136-163
24019484-2	2013	Alternatively, by the transulfuration pathway, homocysteine is transformed to hydrogen sulphide (H2S), through multiple steps involving cystathionine beta-synthase and cystathionine gamma-lyase.	Hydrogen Sulfide	78-95	cystathionine beta-synthase	Homo sapiens	136-163
24019484-2	2013	Alternatively, by the transulfuration pathway, homocysteine is transformed to hydrogen sulphide (H2S), through multiple steps involving cystathionine beta-synthase and cystathionine gamma-lyase.	Hydrogen Sulfide	97-100	cystathionine beta-synthase	Homo sapiens	136-163
23592311-4	2013	These mice lack mouse CBS and express a missense mutant human CBS enzyme (either p.I278T or p.S466L) that has less than 5% of normal liver CBS activity, resulting in a 10-30-fold elevation in plasma homocysteine levels.	Homocysteine	199-211	cystathionine beta-synthase	Homo sapiens	62-65
23592311-4	2013	These mice lack mouse CBS and express a missense mutant human CBS enzyme (either p.I278T or p.S466L) that has less than 5% of normal liver CBS activity, resulting in a 10-30-fold elevation in plasma homocysteine levels.	Homocysteine	199-211	cystathionine beta-synthase	Homo sapiens	62-65
23858469-0	2013	Oxygen-sensitive mitochondrial accumulation of cystathionine beta-synthase mediated by Lon protease.	Oxygen	0-6	cystathionine beta-synthase	Homo sapiens	47-74
23858469-2	2013	Cystathionine beta-synthase (CBS) contains a prosthetic heme group and catalyzes the production of hydrogen sulfide in mammalian cells.	Heme	56-60	cystathionine beta-synthase	Homo sapiens	0-27
23858469-2	2013	Cystathionine beta-synthase (CBS) contains a prosthetic heme group and catalyzes the production of hydrogen sulfide in mammalian cells.	Heme	56-60	cystathionine beta-synthase	Homo sapiens	29-32
23858469-2	2013	Cystathionine beta-synthase (CBS) contains a prosthetic heme group and catalyzes the production of hydrogen sulfide in mammalian cells.	Hydrogen Sulfide	99-115	cystathionine beta-synthase	Homo sapiens	0-27
23858469-2	2013	Cystathionine beta-synthase (CBS) contains a prosthetic heme group and catalyzes the production of hydrogen sulfide in mammalian cells.	Hydrogen Sulfide	99-115	cystathionine beta-synthase	Homo sapiens	29-32
23858469-6	2013	Lon protease, a major degradation enzyme in mitochondrial matrix, recognized and degraded mitochondrial CBS by specifically targeting at the oxygenated heme group of CBS proteins.	Heme	152-156	cystathionine beta-synthase	Homo sapiens	104-107
23858469-7	2013	The accumulation of CBS in mitochondria increased hydrogen sulfide production, which prevented Ca(2+)-mediated cytochrome c release from mitochondria and decreased reactive oxygen species generation.	Hydrogen Sulfide	50-66	cystathionine beta-synthase	Homo sapiens	20-23
23858469-7	2013	The accumulation of CBS in mitochondria increased hydrogen sulfide production, which prevented Ca(2+)-mediated cytochrome c release from mitochondria and decreased reactive oxygen species generation.	Reactive Oxygen Species	164-187	cystathionine beta-synthase	Homo sapiens	20-23
23858469-8	2013	Mitochondrial accumulation of heme oxygenase-1, another heme protein, was also regulated by oxygen level and Lon protease in the same mechanism as for CBS.	Oxygen	35-41	cystathionine beta-synthase	Homo sapiens	151-154
23836652-0	2013	Tumor-derived hydrogen sulfide, produced by cystathionine-beta-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer.	Hydrogen Sulfide	14-30	cystathionine beta-synthase	Homo sapiens	44-71
23836652-2	2013	Analysis of human colon cancer biopsies and patient-matched normal margin mucosa revealed the selective up-regulation of the H2S-producing enzyme cystathionine-beta-synthase (CBS) in colon cancer, resulting in an increased rate of H2S production.	Hydrogen Sulfide	125-128	cystathionine beta-synthase	Homo sapiens	146-173
23836652-2	2013	Analysis of human colon cancer biopsies and patient-matched normal margin mucosa revealed the selective up-regulation of the H2S-producing enzyme cystathionine-beta-synthase (CBS) in colon cancer, resulting in an increased rate of H2S production.	Hydrogen Sulfide	125-128	cystathionine beta-synthase	Homo sapiens	175-178
23836652-2	2013	Analysis of human colon cancer biopsies and patient-matched normal margin mucosa revealed the selective up-regulation of the H2S-producing enzyme cystathionine-beta-synthase (CBS) in colon cancer, resulting in an increased rate of H2S production.	Hydrogen Sulfide	231-234	cystathionine beta-synthase	Homo sapiens	146-173
23836652-2	2013	Analysis of human colon cancer biopsies and patient-matched normal margin mucosa revealed the selective up-regulation of the H2S-producing enzyme cystathionine-beta-synthase (CBS) in colon cancer, resulting in an increased rate of H2S production.	Hydrogen Sulfide	231-234	cystathionine beta-synthase	Homo sapiens	175-178
23836652-5	2013	ShRNA-mediated silencing of CBS or its pharmacological inhibition with aminooxyacetic acid reduced HCT116 cell proliferation, migration, and invasion; reduced endothelial cell migration in tumor/endothelial cell cocultures; and suppressed mitochondrial function (oxygen consumption, ATP turnover, and respiratory reserve capacity), as well as glycolysis.	Aminooxyacetic Acid	71-90	cystathionine beta-synthase	Homo sapiens	28-31
23836652-5	2013	ShRNA-mediated silencing of CBS or its pharmacological inhibition with aminooxyacetic acid reduced HCT116 cell proliferation, migration, and invasion; reduced endothelial cell migration in tumor/endothelial cell cocultures; and suppressed mitochondrial function (oxygen consumption, ATP turnover, and respiratory reserve capacity), as well as glycolysis.	Oxygen	263-269	cystathionine beta-synthase	Homo sapiens	28-31
23836652-5	2013	ShRNA-mediated silencing of CBS or its pharmacological inhibition with aminooxyacetic acid reduced HCT116 cell proliferation, migration, and invasion; reduced endothelial cell migration in tumor/endothelial cell cocultures; and suppressed mitochondrial function (oxygen consumption, ATP turnover, and respiratory reserve capacity), as well as glycolysis.	Adenosine Triphosphate	283-286	cystathionine beta-synthase	Homo sapiens	28-31
23836652-7	2013	Similarly, CBS silencing of the tumor cells decreased xenograft growth and suppressed neovessel density, suggesting a role for endogenous H2S in tumor angiogenesis.	Hydrogen Sulfide	138-141	cystathionine beta-synthase	Homo sapiens	11-14
23836652-9	2013	In conclusion, H2S produced from CBS serves to (i) maintain colon cancer cellular bioenergetics, thereby supporting tumor growth and proliferation, and (ii) promote angiogenesis and vasorelaxation, consequently providing the tumor with blood and nutritients.	Hydrogen Sulfide	15-18	cystathionine beta-synthase	Homo sapiens	33-36
23836652-10	2013	The current findings identify CBS-derived H2S as a tumor growth factor and anticancer drug target.	Hydrogen Sulfide	42-45	cystathionine beta-synthase	Homo sapiens	30-33
23790103-0	2013	Kinetics of reversible reductive carbonylation of heme in human cystathionine beta-synthase.	Heme	50-54	cystathionine beta-synthase	Homo sapiens	64-91
23790103-1	2013	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Homocysteine	64-76	cystathionine beta-synthase	Homo sapiens	0-27
23790103-1	2013	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Homocysteine	64-76	cystathionine beta-synthase	Homo sapiens	29-32
23790103-1	2013	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Serine	82-88	cystathionine beta-synthase	Homo sapiens	0-27
23790103-1	2013	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Serine	82-88	cystathionine beta-synthase	Homo sapiens	29-32
23790103-5	2013	Reduction of Fe(III)-CBS by dithionite showed a square root dependence on concentration, indicating that the reductant species was the sulfur dioxide radical anion (SO2( -)) that exists in rapid equilibrium with S2O4(2-).	ferric sulfate	13-20	cystathionine beta-synthase	Homo sapiens	21-24
23745510-4	2013	Molecular TPM imaging with SHS-M2 in astrocytes revealed that there is a correlation between the ratiometric analysis and expression levels of cystathionine beta-synthase (CBS), the major enzyme that catalyzes H2S production.	Deuterium	210-213	cystathionine beta-synthase	Homo sapiens	172-175
23790103-1	2013	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Cysteine	68-76	cystathionine beta-synthase	Homo sapiens	0-27
23790103-1	2013	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Cysteine	68-76	cystathionine beta-synthase	Homo sapiens	29-32
23745510-5	2013	In studies involving DJ-1, a Parkinson"s disease (PD) gene, attenuated H2S production in comparison with wild-type controls was observed in DJ-1-knockout astrocytes and brain slices, where CBS expression was decreased.	Deuterium	71-74	cystathionine beta-synthase	Homo sapiens	189-192
23790103-1	2013	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Cystathionine	109-122	cystathionine beta-synthase	Homo sapiens	0-27
23790103-5	2013	Reduction of Fe(III)-CBS by dithionite showed a square root dependence on concentration, indicating that the reductant species was the sulfur dioxide radical anion (SO2( -)) that exists in rapid equilibrium with S2O4(2-).	Dithionite	28-38	cystathionine beta-synthase	Homo sapiens	21-24
23790103-1	2013	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Cystathionine	109-122	cystathionine beta-synthase	Homo sapiens	29-32
23815141-5	2013	Inhibition of cystathionine-beta-synthase activity causes the upstream sequestration of homocysteine and the downstream drop in cysteine and glutathione.	Homocysteine	88-100	cystathionine beta-synthase	Homo sapiens	14-41
23790103-1	2013	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Water	127-132	cystathionine beta-synthase	Homo sapiens	0-27
23790103-1	2013	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Water	127-132	cystathionine beta-synthase	Homo sapiens	29-32
23790103-1	2013	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Hydrogen Sulfide	136-152	cystathionine beta-synthase	Homo sapiens	0-27
23790103-1	2013	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Hydrogen Sulfide	136-152	cystathionine beta-synthase	Homo sapiens	29-32
23790103-1	2013	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Hydrogen Sulfide	154-157	cystathionine beta-synthase	Homo sapiens	0-27
23790103-1	2013	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine with serine or cysteine to form cystathionine and water or hydrogen sulfide (H2S), respectively.	Hydrogen Sulfide	154-157	cystathionine beta-synthase	Homo sapiens	29-32
23790103-2	2013	In addition to pyridoxal phosphate, human CBS has a heme cofactor with cysteine and histidine as ligands.	Pyridoxal Phosphate	15-34	cystathionine beta-synthase	Homo sapiens	42-45
23790103-2	2013	In addition to pyridoxal phosphate, human CBS has a heme cofactor with cysteine and histidine as ligands.	Cysteine	71-79	cystathionine beta-synthase	Homo sapiens	42-45
23790103-2	2013	In addition to pyridoxal phosphate, human CBS has a heme cofactor with cysteine and histidine as ligands.	Histidine	84-93	cystathionine beta-synthase	Homo sapiens	42-45
23790103-3	2013	While Fe(III)-CBS is inert to exogenous ligands, Fe(II)-CBS can be reversibly inhibited by carbon monoxide (CO) and reoxidized by O2 to yield superoxide radical.	ferric sulfate	6-13	cystathionine beta-synthase	Homo sapiens	14-17
23790103-3	2013	While Fe(III)-CBS is inert to exogenous ligands, Fe(II)-CBS can be reversibly inhibited by carbon monoxide (CO) and reoxidized by O2 to yield superoxide radical.	ferric sulfate	6-13	cystathionine beta-synthase	Homo sapiens	56-59
23790103-3	2013	While Fe(III)-CBS is inert to exogenous ligands, Fe(II)-CBS can be reversibly inhibited by carbon monoxide (CO) and reoxidized by O2 to yield superoxide radical.	ammonium ferrous sulfate	49-55	cystathionine beta-synthase	Homo sapiens	56-59
23790103-3	2013	While Fe(III)-CBS is inert to exogenous ligands, Fe(II)-CBS can be reversibly inhibited by carbon monoxide (CO) and reoxidized by O2 to yield superoxide radical.	Carbon Monoxide	91-106	cystathionine beta-synthase	Homo sapiens	56-59
23790103-3	2013	While Fe(III)-CBS is inert to exogenous ligands, Fe(II)-CBS can be reversibly inhibited by carbon monoxide (CO) and reoxidized by O2 to yield superoxide radical.	Carbon Monoxide	108-110	cystathionine beta-synthase	Homo sapiens	56-59
23790103-3	2013	While Fe(III)-CBS is inert to exogenous ligands, Fe(II)-CBS can be reversibly inhibited by carbon monoxide (CO) and reoxidized by O2 to yield superoxide radical.	Superoxides	130-132	cystathionine beta-synthase	Homo sapiens	56-59
23790103-3	2013	While Fe(III)-CBS is inert to exogenous ligands, Fe(II)-CBS can be reversibly inhibited by carbon monoxide (CO) and reoxidized by O2 to yield superoxide radical.	Superoxides	142-160	cystathionine beta-synthase	Homo sapiens	56-59
23790103-4	2013	In this study, we have examined the kinetics of Fe(II)CO-CBS formation and reoxidation.	ammonium ferrous sulfate	48-54	cystathionine beta-synthase	Homo sapiens	57-60
23790103-5	2013	Reduction of Fe(III)-CBS by dithionite showed a square root dependence on concentration, indicating that the reductant species was the sulfur dioxide radical anion (SO2( -)) that exists in rapid equilibrium with S2O4(2-).	sulfur dioxide radical anion	135-163	cystathionine beta-synthase	Homo sapiens	21-24
23790103-5	2013	Reduction of Fe(III)-CBS by dithionite showed a square root dependence on concentration, indicating that the reductant species was the sulfur dioxide radical anion (SO2( -)) that exists in rapid equilibrium with S2O4(2-).	Sulfur Dioxide	165-168	cystathionine beta-synthase	Homo sapiens	21-24
23790103-5	2013	Reduction of Fe(III)-CBS by dithionite showed a square root dependence on concentration, indicating that the reductant species was the sulfur dioxide radical anion (SO2( -)) that exists in rapid equilibrium with S2O4(2-).	s2o4	212-216	cystathionine beta-synthase	Homo sapiens	21-24
23790103-6	2013	Formation of Fe(II)CO-CBS from Fe(II)-CBS and 1 mM CO occurred with a rate constant of (3.1 +- 0.4) x 10(-3) s(-1) (pH 7.4, 25  C).	ammonium ferrous sulfate	13-19	cystathionine beta-synthase	Homo sapiens	22-25
23790103-6	2013	Formation of Fe(II)CO-CBS from Fe(II)-CBS and 1 mM CO occurred with a rate constant of (3.1 +- 0.4) x 10(-3) s(-1) (pH 7.4, 25  C).	ammonium ferrous sulfate	13-19	cystathionine beta-synthase	Homo sapiens	38-41
23790103-6	2013	Formation of Fe(II)CO-CBS from Fe(II)-CBS and 1 mM CO occurred with a rate constant of (3.1 +- 0.4) x 10(-3) s(-1) (pH 7.4, 25  C).	ammonium ferrous sulfate	31-37	cystathionine beta-synthase	Homo sapiens	22-25
23790103-6	2013	Formation of Fe(II)CO-CBS from Fe(II)-CBS and 1 mM CO occurred with a rate constant of (3.1 +- 0.4) x 10(-3) s(-1) (pH 7.4, 25  C).	ammonium ferrous sulfate	31-37	cystathionine beta-synthase	Homo sapiens	38-41
23790103-7	2013	The reaction of Fe(III)-CBS with the reduced form of the flavoprotein methionine synthase reductase in the presence of CO and NADPH resulted in its reduction and carbonylation to form Fe(II)CO-CBS.	ferric sulfate	16-23	cystathionine beta-synthase	Homo sapiens	24-27
23790103-7	2013	The reaction of Fe(III)-CBS with the reduced form of the flavoprotein methionine synthase reductase in the presence of CO and NADPH resulted in its reduction and carbonylation to form Fe(II)CO-CBS.	ferric sulfate	16-23	cystathionine beta-synthase	Homo sapiens	193-196
23790103-7	2013	The reaction of Fe(III)-CBS with the reduced form of the flavoprotein methionine synthase reductase in the presence of CO and NADPH resulted in its reduction and carbonylation to form Fe(II)CO-CBS.	Carbon Monoxide	119-121	cystathionine beta-synthase	Homo sapiens	24-27
23790103-7	2013	The reaction of Fe(III)-CBS with the reduced form of the flavoprotein methionine synthase reductase in the presence of CO and NADPH resulted in its reduction and carbonylation to form Fe(II)CO-CBS.	Carbon Monoxide	119-121	cystathionine beta-synthase	Homo sapiens	193-196
23790103-7	2013	The reaction of Fe(III)-CBS with the reduced form of the flavoprotein methionine synthase reductase in the presence of CO and NADPH resulted in its reduction and carbonylation to form Fe(II)CO-CBS.	NADP	126-131	cystathionine beta-synthase	Homo sapiens	24-27
23790103-7	2013	The reaction of Fe(III)-CBS with the reduced form of the flavoprotein methionine synthase reductase in the presence of CO and NADPH resulted in its reduction and carbonylation to form Fe(II)CO-CBS.	NADP	126-131	cystathionine beta-synthase	Homo sapiens	193-196
23790103-7	2013	The reaction of Fe(III)-CBS with the reduced form of the flavoprotein methionine synthase reductase in the presence of CO and NADPH resulted in its reduction and carbonylation to form Fe(II)CO-CBS.	ammonium ferrous sulfate	184-190	cystathionine beta-synthase	Homo sapiens	24-27
23790103-7	2013	The reaction of Fe(III)-CBS with the reduced form of the flavoprotein methionine synthase reductase in the presence of CO and NADPH resulted in its reduction and carbonylation to form Fe(II)CO-CBS.	ammonium ferrous sulfate	184-190	cystathionine beta-synthase	Homo sapiens	193-196
23790103-8	2013	Fe(II)-CBS was formed as an intermediate with a rate constant of (9.3 +- 2.5) x 10(2) M(-1) s(-1).	ammonium ferrous sulfate	0-6	cystathionine beta-synthase	Homo sapiens	7-10
23790103-9	2013	Reoxidation of Fe(II)CO-CBS by O2 was multiphasic.	ammonium ferrous sulfate	15-21	cystathionine beta-synthase	Homo sapiens	24-27
23790103-9	2013	Reoxidation of Fe(II)CO-CBS by O2 was multiphasic.	Superoxides	31-33	cystathionine beta-synthase	Homo sapiens	24-27
23815141-5	2013	Inhibition of cystathionine-beta-synthase activity causes the upstream sequestration of homocysteine and the downstream drop in cysteine and glutathione.	Cysteine	92-100	cystathionine beta-synthase	Homo sapiens	14-41
23815141-5	2013	Inhibition of cystathionine-beta-synthase activity causes the upstream sequestration of homocysteine and the downstream drop in cysteine and glutathione.	Glutathione	141-152	cystathionine beta-synthase	Homo sapiens	14-41
23428891-2	2013	In mammals, two cytosolic enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), have been shown to be responsible for the endogenous production of sulfide.	Sulfides	173-180	cystathionine beta-synthase	Homo sapiens	35-62
23805308-7	2013	Therefore, cystathionine beta-synthase (CBS), the alternative H2S producing enzyme in the CNS, remains as a more likely potential therapeutic target than 3MST in the treatment of acute stroke through inhibition of H2S production.	Hydrogen Sulfide	62-65	cystathionine beta-synthase	Homo sapiens	11-38
23805308-7	2013	Therefore, cystathionine beta-synthase (CBS), the alternative H2S producing enzyme in the CNS, remains as a more likely potential therapeutic target than 3MST in the treatment of acute stroke through inhibition of H2S production.	Hydrogen Sulfide	62-65	cystathionine beta-synthase	Homo sapiens	40-43
23805308-7	2013	Therefore, cystathionine beta-synthase (CBS), the alternative H2S producing enzyme in the CNS, remains as a more likely potential therapeutic target than 3MST in the treatment of acute stroke through inhibition of H2S production.	Hydrogen Sulfide	214-217	cystathionine beta-synthase	Homo sapiens	11-38
23805308-7	2013	Therefore, cystathionine beta-synthase (CBS), the alternative H2S producing enzyme in the CNS, remains as a more likely potential therapeutic target than 3MST in the treatment of acute stroke through inhibition of H2S production.	Hydrogen Sulfide	214-217	cystathionine beta-synthase	Homo sapiens	40-43
23488457-2	2013	Two major sources for endogenous enzymatic production of H2S are cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE).	Hydrogen Sulfide	57-60	cystathionine beta-synthase	Homo sapiens	65-92
23488457-2	2013	Two major sources for endogenous enzymatic production of H2S are cystathionine beta synthase (CBS) and cystathionine gamma lyase (CSE).	Hydrogen Sulfide	57-60	cystathionine beta-synthase	Homo sapiens	94-97
23488457-3	2013	In the present study, we examined the selectivity of commonly used pharmacological inhibitors of H2S biosynthesis towards CSE and CBS.	Hydrogen Sulfide	97-100	cystathionine beta-synthase	Homo sapiens	130-133
23488457-8	2013	On the other hand, aminooxyacetic acid (AOAA), a frequently used CBS inhibitor, was more potent in inhibiting CSE compared with BCA and PAG (IC50 1.1 +- 0.1 muM); the IC50 for AOAA for inhibiting CBS was 8.5 +- 0.7 muM.	Aminooxyacetic Acid	19-38	cystathionine beta-synthase	Homo sapiens	65-68
23488457-8	2013	On the other hand, aminooxyacetic acid (AOAA), a frequently used CBS inhibitor, was more potent in inhibiting CSE compared with BCA and PAG (IC50 1.1 +- 0.1 muM); the IC50 for AOAA for inhibiting CBS was 8.5 +- 0.7 muM.	Aminooxyacetic Acid	19-38	cystathionine beta-synthase	Homo sapiens	196-199
23488457-8	2013	On the other hand, aminooxyacetic acid (AOAA), a frequently used CBS inhibitor, was more potent in inhibiting CSE compared with BCA and PAG (IC50 1.1 +- 0.1 muM); the IC50 for AOAA for inhibiting CBS was 8.5 +- 0.7 muM.	Aminooxyacetic Acid	40-44	cystathionine beta-synthase	Homo sapiens	65-68
23488457-8	2013	On the other hand, aminooxyacetic acid (AOAA), a frequently used CBS inhibitor, was more potent in inhibiting CSE compared with BCA and PAG (IC50 1.1 +- 0.1 muM); the IC50 for AOAA for inhibiting CBS was 8.5 +- 0.7 muM.	Aminooxyacetic Acid	40-44	cystathionine beta-synthase	Homo sapiens	196-199
23488457-8	2013	On the other hand, aminooxyacetic acid (AOAA), a frequently used CBS inhibitor, was more potent in inhibiting CSE compared with BCA and PAG (IC50 1.1 +- 0.1 muM); the IC50 for AOAA for inhibiting CBS was 8.5 +- 0.7 muM.	3-cyanoalanine	128-131	cystathionine beta-synthase	Homo sapiens	65-68
23488457-8	2013	On the other hand, aminooxyacetic acid (AOAA), a frequently used CBS inhibitor, was more potent in inhibiting CSE compared with BCA and PAG (IC50 1.1 +- 0.1 muM); the IC50 for AOAA for inhibiting CBS was 8.5 +- 0.7 muM.	propargylglycine	136-139	cystathionine beta-synthase	Homo sapiens	65-68
23488457-10	2013	Trifluoroalanine and hydroxylamine, two compounds that have also been used to block H2S biosynthesis, blocked the activity of CBS and CSE.	3,3,3-trifluoro-l-alanine	0-16	cystathionine beta-synthase	Homo sapiens	126-129
23488457-10	2013	Trifluoroalanine and hydroxylamine, two compounds that have also been used to block H2S biosynthesis, blocked the activity of CBS and CSE.	Hydroxylamine	21-34	cystathionine beta-synthase	Homo sapiens	126-129
23488457-10	2013	Trifluoroalanine and hydroxylamine, two compounds that have also been used to block H2S biosynthesis, blocked the activity of CBS and CSE.	Hydrogen Sulfide	84-87	cystathionine beta-synthase	Homo sapiens	126-129
23488457-11	2013	Trifluoroalanine had a fourfold lower IC50 for CBS versus CSE, while hydroxylamine was 60-fold more selective against CSE.	3,3,3-trifluoro-l-alanine	0-16	cystathionine beta-synthase	Homo sapiens	47-50
23488457-12	2013	CONCLUSIONS AND IMPLICATIONS: In conclusion, although PAG, AVG and BCA exhibit selectivity in inhibiting CSE versus CBS, no selective pharmacological CBS inhibitor is currently available.	propargylglycine	54-57	cystathionine beta-synthase	Homo sapiens	116-119
23488457-12	2013	CONCLUSIONS AND IMPLICATIONS: In conclusion, although PAG, AVG and BCA exhibit selectivity in inhibiting CSE versus CBS, no selective pharmacological CBS inhibitor is currently available.	3-cyanoalanine	67-70	cystathionine beta-synthase	Homo sapiens	116-119
23449670-3	2013	This study was designed to examine plasticity of voltage-gated Na(+) channel activities and roles for the endogenous hydrogen sulfide-producing enzyme cystathionine beta-synthetase (CBS) in chronic visceral hyperalgesia.	Hydrogen Sulfide	117-133	cystathionine beta-synthase	Homo sapiens	182-185
23449670-11	2013	Administration of O-(carboxymethyl)hydroxylamine hemihydrochloride (AOAA), an inhibitor for CBS, remarkably suppressed Na(+) current density and reduced expression of Na(V)1.7 and Na(V)1.8.	Carboxymethoxylamine hemihydrochloride	18-66	cystathionine beta-synthase	Homo sapiens	92-95
23449670-11	2013	Administration of O-(carboxymethyl)hydroxylamine hemihydrochloride (AOAA), an inhibitor for CBS, remarkably suppressed Na(+) current density and reduced expression of Na(V)1.7 and Na(V)1.8.	Aminooxyacetic Acid	68-72	cystathionine beta-synthase	Homo sapiens	92-95
23428891-2	2013	In mammals, two cytosolic enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), have been shown to be responsible for the endogenous production of sulfide.	Sulfides	173-180	cystathionine beta-synthase	Homo sapiens	64-67
23215842-6	2013	Expression of the H2S-synthesizing enzymes cystathionine beta-synthase (CBS), cystathionine gamma lyase (CSE) and 3-mercaptopyruvate sulphurtransferase (3-MST) were measured by Western blotting.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	43-70
23512751-0	2013	Identification of cystathionine beta-synthase inhibitors using a hydrogen sulfide selective probe.	Hydrogen Sulfide	65-81	cystathionine beta-synthase	Homo sapiens	18-45
23512751-1	2013	Buzzing with activity: A hydrogen sulfide selective fluorogenic probe, 7-azido-4-methylcoumarin (AzMC), serves as a highly sensitive assay for cystathionine beta-synthase activity, and is suitable for the high-throughput discovery of novel enzyme inhibitors.	Hydrogen Sulfide	25-41	cystathionine beta-synthase	Homo sapiens	143-170
23512751-1	2013	Buzzing with activity: A hydrogen sulfide selective fluorogenic probe, 7-azido-4-methylcoumarin (AzMC), serves as a highly sensitive assay for cystathionine beta-synthase activity, and is suitable for the high-throughput discovery of novel enzyme inhibitors.	7-azido-4-methylcoumarin	71-95	cystathionine beta-synthase	Homo sapiens	143-170
23512751-1	2013	Buzzing with activity: A hydrogen sulfide selective fluorogenic probe, 7-azido-4-methylcoumarin (AzMC), serves as a highly sensitive assay for cystathionine beta-synthase activity, and is suitable for the high-throughput discovery of novel enzyme inhibitors.	7-azido-4-methylcoumarin	97-101	cystathionine beta-synthase	Homo sapiens	143-170
26583539-3	2013	In this work, through high-level coupled cluster calculations (CCSD(T)/CBS), we have examined a variety of density functionals for their performances in the whole catalytic cycle of water oxidation catalyzed by mononuclear Ru-based WOCs.	Water	182-187	cystathionine beta-synthase	Homo sapiens	71-74
23376738-0	2013	L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H2S pathway.	Cysteine	0-10	cystathionine beta-synthase	Homo sapiens	87-90
23376738-0	2013	L-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H2S pathway.	Hydrogen Sulfide	91-94	cystathionine beta-synthase	Homo sapiens	87-90
23376738-3	2013	Moreover, pre-treatment with aminooxyacetic acid, the inhibitor of CBS or knockdown of CBS in using siRNA, significantly attenuated the effects of L-cysteine on elevated H2S levels and the cell proliferation; it also effectively suppressed L-cysteine-induced neurogenesis and astrocytogenesis.	Aminooxyacetic Acid	29-48	cystathionine beta-synthase	Homo sapiens	67-70
23376738-3	2013	Moreover, pre-treatment with aminooxyacetic acid, the inhibitor of CBS or knockdown of CBS in using siRNA, significantly attenuated the effects of L-cysteine on elevated H2S levels and the cell proliferation; it also effectively suppressed L-cysteine-induced neurogenesis and astrocytogenesis.	Aminooxyacetic Acid	29-48	cystathionine beta-synthase	Homo sapiens	87-90
23376738-3	2013	Moreover, pre-treatment with aminooxyacetic acid, the inhibitor of CBS or knockdown of CBS in using siRNA, significantly attenuated the effects of L-cysteine on elevated H2S levels and the cell proliferation; it also effectively suppressed L-cysteine-induced neurogenesis and astrocytogenesis.	Cysteine	147-157	cystathionine beta-synthase	Homo sapiens	67-70
23376738-3	2013	Moreover, pre-treatment with aminooxyacetic acid, the inhibitor of CBS or knockdown of CBS in using siRNA, significantly attenuated the effects of L-cysteine on elevated H2S levels and the cell proliferation; it also effectively suppressed L-cysteine-induced neurogenesis and astrocytogenesis.	Cysteine	147-157	cystathionine beta-synthase	Homo sapiens	87-90
23376738-3	2013	Moreover, pre-treatment with aminooxyacetic acid, the inhibitor of CBS or knockdown of CBS in using siRNA, significantly attenuated the effects of L-cysteine on elevated H2S levels and the cell proliferation; it also effectively suppressed L-cysteine-induced neurogenesis and astrocytogenesis.	Hydrogen Sulfide	170-173	cystathionine beta-synthase	Homo sapiens	67-70
23376738-3	2013	Moreover, pre-treatment with aminooxyacetic acid, the inhibitor of CBS or knockdown of CBS in using siRNA, significantly attenuated the effects of L-cysteine on elevated H2S levels and the cell proliferation; it also effectively suppressed L-cysteine-induced neurogenesis and astrocytogenesis.	Hydrogen Sulfide	170-173	cystathionine beta-synthase	Homo sapiens	87-90
23376738-3	2013	Moreover, pre-treatment with aminooxyacetic acid, the inhibitor of CBS or knockdown of CBS in using siRNA, significantly attenuated the effects of L-cysteine on elevated H2S levels and the cell proliferation; it also effectively suppressed L-cysteine-induced neurogenesis and astrocytogenesis.	Cysteine	240-250	cystathionine beta-synthase	Homo sapiens	87-90
23376738-5	2013	Taken together, the present data suggest that L-cysteine can enhance proliferation and differentiation of NSCs via the CBS/H2S pathway, which may serve as a useful inference for elucidating its role in regulating the fate of NSCs in physiological and pathological settings.	Cysteine	46-56	cystathionine beta-synthase	Homo sapiens	119-122
23376738-5	2013	Taken together, the present data suggest that L-cysteine can enhance proliferation and differentiation of NSCs via the CBS/H2S pathway, which may serve as a useful inference for elucidating its role in regulating the fate of NSCs in physiological and pathological settings.	Hydrogen Sulfide	123-126	cystathionine beta-synthase	Homo sapiens	119-122
23421317-2	2013	Studies have shown that, in addition to overexpression of the Cystathionine beta-synthase (CBS) gene, polymorphisms in genes involved in folate/homocysteine (Hcy) metabolism may also influence the concentrations of metabolites of this pathway.	Homocysteine	144-156	cystathionine beta-synthase	Homo sapiens	62-89
23410520-3	2013	H2S is produced endogenously by catalytic activity of cystathionine beta-synthase and cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	54-81
23421317-2	2013	Studies have shown that, in addition to overexpression of the Cystathionine beta-synthase (CBS) gene, polymorphisms in genes involved in folate/homocysteine (Hcy) metabolism may also influence the concentrations of metabolites of this pathway.	Homocysteine	144-156	cystathionine beta-synthase	Homo sapiens	91-94
22907821-2	2013	It is synthesised from cysteine via cystathionine beta-synthase and cystathionine gamma-lyase.	Cysteine	23-31	cystathionine beta-synthase	Homo sapiens	36-63
23063804-2	2013	MATERIALS AND METHODS: We used immunohistochemistry to determine the expression of the H2S synthesis enzymes cystathionine gamma-lyase and cystathionine beta-synthase.	Hydrogen Sulfide	87-90	cystathionine beta-synthase	Homo sapiens	139-166
23063804-8	2013	The H2S donor GYY4137 (0.1 nM to 10 muM) induced potent, concentration dependent relaxation, which was not modified by neuronal voltage gated Na(+) channels, or cystathionine gamma-lyase or cystathionine beta-synthase blockade.	Hydrogen Sulfide	4-7	cystathionine beta-synthase	Homo sapiens	190-217
23063804-8	2013	The H2S donor GYY4137 (0.1 nM to 10 muM) induced potent, concentration dependent relaxation, which was not modified by neuronal voltage gated Na(+) channels, or cystathionine gamma-lyase or cystathionine beta-synthase blockade.	GYY 4137	14-21	cystathionine beta-synthase	Homo sapiens	190-217
26105871-2	2013	INTRODUCTION: Cystathionine-b-synthase (CBS) produces the vasodilatory and anti-inflammatory hydrogen sulfide (H2S) by conversion of homocysteine (Hcy).	Hydrogen Sulfide	93-109	cystathionine beta-synthase	Homo sapiens	14-38
26105871-2	2013	INTRODUCTION: Cystathionine-b-synthase (CBS) produces the vasodilatory and anti-inflammatory hydrogen sulfide (H2S) by conversion of homocysteine (Hcy).	Hydrogen Sulfide	93-109	cystathionine beta-synthase	Homo sapiens	40-43
26105871-2	2013	INTRODUCTION: Cystathionine-b-synthase (CBS) produces the vasodilatory and anti-inflammatory hydrogen sulfide (H2S) by conversion of homocysteine (Hcy).	Hydrogen Sulfide	111-114	cystathionine beta-synthase	Homo sapiens	14-38
26105871-2	2013	INTRODUCTION: Cystathionine-b-synthase (CBS) produces the vasodilatory and anti-inflammatory hydrogen sulfide (H2S) by conversion of homocysteine (Hcy).	Hydrogen Sulfide	111-114	cystathionine beta-synthase	Homo sapiens	40-43
26105871-2	2013	INTRODUCTION: Cystathionine-b-synthase (CBS) produces the vasodilatory and anti-inflammatory hydrogen sulfide (H2S) by conversion of homocysteine (Hcy).	Homocysteine	133-145	cystathionine beta-synthase	Homo sapiens	14-38
26105871-2	2013	INTRODUCTION: Cystathionine-b-synthase (CBS) produces the vasodilatory and anti-inflammatory hydrogen sulfide (H2S) by conversion of homocysteine (Hcy).	Homocysteine	133-145	cystathionine beta-synthase	Homo sapiens	40-43
26105871-2	2013	INTRODUCTION: Cystathionine-b-synthase (CBS) produces the vasodilatory and anti-inflammatory hydrogen sulfide (H2S) by conversion of homocysteine (Hcy).	Homocysteine	147-150	cystathionine beta-synthase	Homo sapiens	14-38
26105871-2	2013	INTRODUCTION: Cystathionine-b-synthase (CBS) produces the vasodilatory and anti-inflammatory hydrogen sulfide (H2S) by conversion of homocysteine (Hcy).	Homocysteine	147-150	cystathionine beta-synthase	Homo sapiens	40-43
26105871-5	2013	OBJECTIVES: Aberrant CBS gene expression may play a role in hyperhomocysteinemia and decreased H2S and could be involved in pathogenesis of PE.	Hydrogen Sulfide	95-98	cystathionine beta-synthase	Homo sapiens	21-24
26105871-15	2013	Altered effectiveness of CBS may affect PE through decreased H2S production or Hcy accumulation.	Hydrogen Sulfide	61-64	cystathionine beta-synthase	Homo sapiens	25-28
26105871-15	2013	Altered effectiveness of CBS may affect PE through decreased H2S production or Hcy accumulation.	Homocysteine	79-82	cystathionine beta-synthase	Homo sapiens	25-28
23281120-1	2013	The hydrogen-bonded complexes of phenylacetylene, 4-fluorophenylacetylene, 2-fluorophenylacetylene, and 2,6-difluorophenylacetylene with ammonia are investigated using IR-UV double resonance spectroscopy in combination with high-level ab initio calculations at the CCSD(T)/CBS level of theory.	Hydrogen	4-12	cystathionine beta-synthase	Homo sapiens	273-276
23281120-1	2013	The hydrogen-bonded complexes of phenylacetylene, 4-fluorophenylacetylene, 2-fluorophenylacetylene, and 2,6-difluorophenylacetylene with ammonia are investigated using IR-UV double resonance spectroscopy in combination with high-level ab initio calculations at the CCSD(T)/CBS level of theory.	phenylacetylene	33-48	cystathionine beta-synthase	Homo sapiens	273-276
23281120-1	2013	The hydrogen-bonded complexes of phenylacetylene, 4-fluorophenylacetylene, 2-fluorophenylacetylene, and 2,6-difluorophenylacetylene with ammonia are investigated using IR-UV double resonance spectroscopy in combination with high-level ab initio calculations at the CCSD(T)/CBS level of theory.	2-ethynyl-1,3-difluorobenzene	104-131	cystathionine beta-synthase	Homo sapiens	273-276
23281120-1	2013	The hydrogen-bonded complexes of phenylacetylene, 4-fluorophenylacetylene, 2-fluorophenylacetylene, and 2,6-difluorophenylacetylene with ammonia are investigated using IR-UV double resonance spectroscopy in combination with high-level ab initio calculations at the CCSD(T)/CBS level of theory.	Ammonia	137-144	cystathionine beta-synthase	Homo sapiens	273-276
22907821-12	2013	Cysteine and the G1364T and 844ins68 variants of the cystathionine gamma-lyase and cystathionine beta-synthase genes, respectively, are the biological determinants of H(2)S synthesis, and all three are shown here to influence the hypertensive phenotype.	Cysteine	0-8	cystathionine beta-synthase	Homo sapiens	83-110
22907821-12	2013	Cysteine and the G1364T and 844ins68 variants of the cystathionine gamma-lyase and cystathionine beta-synthase genes, respectively, are the biological determinants of H(2)S synthesis, and all three are shown here to influence the hypertensive phenotype.	Hydrogen Sulfide	167-172	cystathionine beta-synthase	Homo sapiens	83-110
23153577-1	2013	Hydrogen sulfide (H(2)S) is a gaseous neuromodulator endogenously produced in the brain by the enzyme cystathionine beta-synthase (CBS).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	102-129
22872231-2	2013	Cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), the main enzymes in the transsulfuration pathway, catalyze H(2)S production in mammalian tissues.	Hydrogen Sulfide	130-135	cystathionine beta-synthase	Homo sapiens	0-27
23303708-3	2013	The expression and distribution pattern of the H(2) S-synthesizing enzymes cystathione gamma-lyase (CSE) and cystathione beta-synthase (CBS) were investigated in healthy and allergic nasal mucosa.	Hydrogen Sulfide	47-53	cystathionine beta-synthase	Homo sapiens	109-134
23303708-3	2013	The expression and distribution pattern of the H(2) S-synthesizing enzymes cystathione gamma-lyase (CSE) and cystathione beta-synthase (CBS) were investigated in healthy and allergic nasal mucosa.	Hydrogen Sulfide	47-53	cystathionine beta-synthase	Homo sapiens	136-139
23303708-10	2013	CONCLUSIONS: The current findings indicate that, in parallel with increased expression levels of CSE and CBS, H(2) S is upregulated in nasal mucosa and plasma of allergic patients.	Hydrogen Sulfide	110-116	cystathionine beta-synthase	Homo sapiens	105-108
23303708-11	2013	Based on localization of CSE and CBS, H(2) S may play multiple functions in human nasal mucosa, contributing to the development of allergic symptoms such as rhinorrhea, sneezing, and nasal stuffiness.	Hydrogen Sulfide	38-44	cystathionine beta-synthase	Homo sapiens	33-36
22986502-3	2013	Cystathionine beta-synthase (CBS) catalyzes the first step of homocysteine transsulfuration as a rate-limiting enzyme.	Homocysteine	62-74	cystathionine beta-synthase	Homo sapiens	0-27
22986502-3	2013	Cystathionine beta-synthase (CBS) catalyzes the first step of homocysteine transsulfuration as a rate-limiting enzyme.	Homocysteine	62-74	cystathionine beta-synthase	Homo sapiens	29-32
22986502-9	2013	Consequently, the carriers with genetically increased CBS expression would benefit from the protection due to the low homocysteine levels maintained by CBS in certain cells during the critical heart development stages.	Homocysteine	118-130	cystathionine beta-synthase	Homo sapiens	54-57
23153577-1	2013	Hydrogen sulfide (H(2)S) is a gaseous neuromodulator endogenously produced in the brain by the enzyme cystathionine beta-synthase (CBS).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	131-134
23153577-1	2013	Hydrogen sulfide (H(2)S) is a gaseous neuromodulator endogenously produced in the brain by the enzyme cystathionine beta-synthase (CBS).	Hydrogen Sulfide	18-23	cystathionine beta-synthase	Homo sapiens	102-129
23153577-1	2013	Hydrogen sulfide (H(2)S) is a gaseous neuromodulator endogenously produced in the brain by the enzyme cystathionine beta-synthase (CBS).	Hydrogen Sulfide	18-23	cystathionine beta-synthase	Homo sapiens	131-134
23153577-4	2013	Intracerebroventricular (icv) microinjection of aminooxyacetate (AOA, a CBS inhibitor; 100 pmol) did not affect basal PGE(2) production and Tb, but enhanced LPS-induced PGE(2) production and fever, indicating that endogenous H(2)S plays an antipyretic role.	Aminooxyacetic Acid	48-63	cystathionine beta-synthase	Homo sapiens	72-75
23153577-9	2013	The LPS-induced PGE(2) production was potentiated by AOA (the CBS inhibitor) and inhibited by the H(2)S donor.	Dinoprostone	16-22	cystathionine beta-synthase	Homo sapiens	62-65
22985361-0	2013	Human cystathionine beta-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM.	S-Adenosylmethionine	82-102	cystathionine beta-synthase	Homo sapiens	6-33
23002992-1	2013	Cystathionine beta-synthase (CBS) is the first and rate-limiting enzyme in the transsulfuration pathway, which is critical for the synthesis of cysteine from methionine in eukaryotes.	Cysteine	144-152	cystathionine beta-synthase	Homo sapiens	0-27
23002992-1	2013	Cystathionine beta-synthase (CBS) is the first and rate-limiting enzyme in the transsulfuration pathway, which is critical for the synthesis of cysteine from methionine in eukaryotes.	Cysteine	144-152	cystathionine beta-synthase	Homo sapiens	29-32
23002992-1	2013	Cystathionine beta-synthase (CBS) is the first and rate-limiting enzyme in the transsulfuration pathway, which is critical for the synthesis of cysteine from methionine in eukaryotes.	Methionine	158-168	cystathionine beta-synthase	Homo sapiens	0-27
23002992-1	2013	Cystathionine beta-synthase (CBS) is the first and rate-limiting enzyme in the transsulfuration pathway, which is critical for the synthesis of cysteine from methionine in eukaryotes.	Methionine	158-168	cystathionine beta-synthase	Homo sapiens	29-32
23002992-2	2013	CBS uses coenzyme pyridoxal 5"-phosphate (PLP) for catalysis, and S-adenosylmethionine regulates the activity of human CBS, but not yeast CBS.	Pyridoxal Phosphate	18-40	cystathionine beta-synthase	Homo sapiens	0-3
23002992-2	2013	CBS uses coenzyme pyridoxal 5"-phosphate (PLP) for catalysis, and S-adenosylmethionine regulates the activity of human CBS, but not yeast CBS.	Pyridoxal Phosphate	42-45	cystathionine beta-synthase	Homo sapiens	0-3
23002992-2	2013	CBS uses coenzyme pyridoxal 5"-phosphate (PLP) for catalysis, and S-adenosylmethionine regulates the activity of human CBS, but not yeast CBS.	S-Adenosylmethionine	66-86	cystathionine beta-synthase	Homo sapiens	119-122
23002992-2	2013	CBS uses coenzyme pyridoxal 5"-phosphate (PLP) for catalysis, and S-adenosylmethionine regulates the activity of human CBS, but not yeast CBS.	S-Adenosylmethionine	66-86	cystathionine beta-synthase	Homo sapiens	119-122
23002992-3	2013	Human and fruit fly CBS contain heme; however, the role for heme is not clear.	Heme	32-36	cystathionine beta-synthase	Homo sapiens	20-23
23002992-6	2013	The DmCBS heme coordination environment, the reactivity, and the accompanying effects on enzyme activity are similar to those of human CBS.	Heme	10-14	cystathionine beta-synthase	Homo sapiens	6-9
23002992-8	2013	The Fe(II) heme in DmCBS is less stable than that in human CBS, undergoing more facile reoxidation and ligand exchange.	fe(ii) heme	4-15	cystathionine beta-synthase	Homo sapiens	21-24
23002992-9	2013	In both CBS proteins, the overall stability of the protein is correlated with the heme oxidation state.	Heme	82-86	cystathionine beta-synthase	Homo sapiens	8-11
23002992-11	2013	Together, the results suggest that heme incorporation and AdoMet regulation in CBS are not correlated, possibly providing two independent means for regulating the enzyme.	Heme	35-39	cystathionine beta-synthase	Homo sapiens	79-82
22985361-0	2013	Human cystathionine beta-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM.	S-Adenosylmethionine	82-102	cystathionine beta-synthase	Homo sapiens	35-38
22985361-0	2013	Human cystathionine beta-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM.	S-Adenosylmethionine	82-102	cystathionine beta-synthase	Homo sapiens	132-135
22985361-1	2013	CBS (cystathionine beta-synthase) is a multidomain tetrameric enzyme essential in the regulation of homocysteine metabolism, whose activity is enhanced by the allosteric regulator SAM (S-adenosylmethionine).	Homocysteine	100-112	cystathionine beta-synthase	Homo sapiens	0-3
22985361-1	2013	CBS (cystathionine beta-synthase) is a multidomain tetrameric enzyme essential in the regulation of homocysteine metabolism, whose activity is enhanced by the allosteric regulator SAM (S-adenosylmethionine).	Homocysteine	100-112	cystathionine beta-synthase	Homo sapiens	5-32
22985361-1	2013	CBS (cystathionine beta-synthase) is a multidomain tetrameric enzyme essential in the regulation of homocysteine metabolism, whose activity is enhanced by the allosteric regulator SAM (S-adenosylmethionine).	S-Adenosylmethionine	185-205	cystathionine beta-synthase	Homo sapiens	0-3
22985361-1	2013	CBS (cystathionine beta-synthase) is a multidomain tetrameric enzyme essential in the regulation of homocysteine metabolism, whose activity is enhanced by the allosteric regulator SAM (S-adenosylmethionine).	S-Adenosylmethionine	185-205	cystathionine beta-synthase	Homo sapiens	5-32
23340406-2	2013	Hydrogen sulphide is known to be produced from L-cysteine by cystathionine beta-synthase, cystathionine gamma-lyase and 3-mercaptopyruvate sulfurtransferase coupled with cysteine aminotransferase.	Hydrogen Sulfide	0-17	cystathionine beta-synthase	Homo sapiens	61-88
23733603-1	2013	We describe a family illustrating the diagnostic difficulties occurring when pyridoxine-responsive cystathionine beta-synthase (CBS) deficiency presents with thrombotic disease without associated ocular, skeletal, or CNS abnormalities, a situation increasingly recognized.	Pyridoxine	77-87	cystathionine beta-synthase	Homo sapiens	99-126
23340406-2	2013	Hydrogen sulphide is known to be produced from L-cysteine by cystathionine beta-synthase, cystathionine gamma-lyase and 3-mercaptopyruvate sulfurtransferase coupled with cysteine aminotransferase.	Cysteine	47-57	cystathionine beta-synthase	Homo sapiens	61-88
23093113-4	2012	Based on high level coupled-cluster (estimated CCSD(T)/CBS) computations it was concluded that benzene is more aromatic/stable than pyridine by 2.2 kcal mol(-1).	Benzene	95-102	cystathionine beta-synthase	Homo sapiens	55-58
23631191-3	2013	In pancreatic beta-cells, H2S can be produced by cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	26-29	cystathionine beta-synthase	Homo sapiens	49-76
23144459-2	2012	The biogenesis of H(2)S involves the cytoplasmic transsulfuration enzymes, cystathionine beta-synthase and gamma-cystathionase, whereas its catabolism occurs in the mitochondrion and couples to the energy-yielding electron transfer chain.	Hydrogen Sulfide	18-23	cystathionine beta-synthase	Homo sapiens	75-102
23124209-1	2012	Human cystathionine beta-synthase (CBS), a novel heme-containing pyridoxal 5"-phosphate enzyme, catalyzes the condensation of homocysteine and serine or cysteine to produce cystathionine and H(2)O or H(2)S, respectively.	Pyridoxal Phosphate	65-87	cystathionine beta-synthase	Homo sapiens	6-33
23124209-1	2012	Human cystathionine beta-synthase (CBS), a novel heme-containing pyridoxal 5"-phosphate enzyme, catalyzes the condensation of homocysteine and serine or cysteine to produce cystathionine and H(2)O or H(2)S, respectively.	Pyridoxal Phosphate	65-87	cystathionine beta-synthase	Homo sapiens	35-38
23124209-1	2012	Human cystathionine beta-synthase (CBS), a novel heme-containing pyridoxal 5"-phosphate enzyme, catalyzes the condensation of homocysteine and serine or cysteine to produce cystathionine and H(2)O or H(2)S, respectively.	Homocysteine	126-138	cystathionine beta-synthase	Homo sapiens	6-33
23124209-1	2012	Human cystathionine beta-synthase (CBS), a novel heme-containing pyridoxal 5"-phosphate enzyme, catalyzes the condensation of homocysteine and serine or cysteine to produce cystathionine and H(2)O or H(2)S, respectively.	Homocysteine	126-138	cystathionine beta-synthase	Homo sapiens	35-38
23124209-1	2012	Human cystathionine beta-synthase (CBS), a novel heme-containing pyridoxal 5"-phosphate enzyme, catalyzes the condensation of homocysteine and serine or cysteine to produce cystathionine and H(2)O or H(2)S, respectively.	Serine	143-149	cystathionine beta-synthase	Homo sapiens	6-33
23124209-1	2012	Human cystathionine beta-synthase (CBS), a novel heme-containing pyridoxal 5"-phosphate enzyme, catalyzes the condensation of homocysteine and serine or cysteine to produce cystathionine and H(2)O or H(2)S, respectively.	Serine	143-149	cystathionine beta-synthase	Homo sapiens	35-38
23124209-1	2012	Human cystathionine beta-synthase (CBS), a novel heme-containing pyridoxal 5"-phosphate enzyme, catalyzes the condensation of homocysteine and serine or cysteine to produce cystathionine and H(2)O or H(2)S, respectively.	Cysteine	130-138	cystathionine beta-synthase	Homo sapiens	6-33
23124209-1	2012	Human cystathionine beta-synthase (CBS), a novel heme-containing pyridoxal 5"-phosphate enzyme, catalyzes the condensation of homocysteine and serine or cysteine to produce cystathionine and H(2)O or H(2)S, respectively.	Cysteine	130-138	cystathionine beta-synthase	Homo sapiens	35-38
23124209-1	2012	Human cystathionine beta-synthase (CBS), a novel heme-containing pyridoxal 5"-phosphate enzyme, catalyzes the condensation of homocysteine and serine or cysteine to produce cystathionine and H(2)O or H(2)S, respectively.	Cystathionine	6-19	cystathionine beta-synthase	Homo sapiens	35-38
23124209-1	2012	Human cystathionine beta-synthase (CBS), a novel heme-containing pyridoxal 5"-phosphate enzyme, catalyzes the condensation of homocysteine and serine or cysteine to produce cystathionine and H(2)O or H(2)S, respectively.	Water	191-196	cystathionine beta-synthase	Homo sapiens	6-33
23124209-1	2012	Human cystathionine beta-synthase (CBS), a novel heme-containing pyridoxal 5"-phosphate enzyme, catalyzes the condensation of homocysteine and serine or cysteine to produce cystathionine and H(2)O or H(2)S, respectively.	Water	191-196	cystathionine beta-synthase	Homo sapiens	35-38
23124209-1	2012	Human cystathionine beta-synthase (CBS), a novel heme-containing pyridoxal 5"-phosphate enzyme, catalyzes the condensation of homocysteine and serine or cysteine to produce cystathionine and H(2)O or H(2)S, respectively.	Hydrogen Sulfide	200-205	cystathionine beta-synthase	Homo sapiens	6-33
23124209-1	2012	Human cystathionine beta-synthase (CBS), a novel heme-containing pyridoxal 5"-phosphate enzyme, catalyzes the condensation of homocysteine and serine or cysteine to produce cystathionine and H(2)O or H(2)S, respectively.	Hydrogen Sulfide	200-205	cystathionine beta-synthase	Homo sapiens	35-38
23124209-2	2012	The presence of heme in CBS has limited spectrophotometric characterization of reaction intermediates by masking the absorption of the pyridoxal 5"-phosphate cofactor.	Heme	16-20	cystathionine beta-synthase	Homo sapiens	24-27
23124209-2	2012	The presence of heme in CBS has limited spectrophotometric characterization of reaction intermediates by masking the absorption of the pyridoxal 5"-phosphate cofactor.	Pyridoxal Phosphate	135-157	cystathionine beta-synthase	Homo sapiens	24-27
23124209-4	2012	The reactions of L-serine and L-cysteine with CBS resulted in the formation of a common aminoacrylate intermediate (k(obs) = 0.96 +- 0.02 and 0.38 +- 0.01 mM(-1) s(-1), respectively, at 24  C) with concomitant loss of H(2)O and H(2)S and without detectable accumulation of the external aldimine or other intermediates.	Serine	17-25	cystathionine beta-synthase	Homo sapiens	46-49
23124209-4	2012	The reactions of L-serine and L-cysteine with CBS resulted in the formation of a common aminoacrylate intermediate (k(obs) = 0.96 +- 0.02 and 0.38 +- 0.01 mM(-1) s(-1), respectively, at 24  C) with concomitant loss of H(2)O and H(2)S and without detectable accumulation of the external aldimine or other intermediates.	Cysteine	30-40	cystathionine beta-synthase	Homo sapiens	46-49
23124209-4	2012	The reactions of L-serine and L-cysteine with CBS resulted in the formation of a common aminoacrylate intermediate (k(obs) = 0.96 +- 0.02 and 0.38 +- 0.01 mM(-1) s(-1), respectively, at 24  C) with concomitant loss of H(2)O and H(2)S and without detectable accumulation of the external aldimine or other intermediates.	(Z)-3-aminoacrylate	88-101	cystathionine beta-synthase	Homo sapiens	46-49
23124209-4	2012	The reactions of L-serine and L-cysteine with CBS resulted in the formation of a common aminoacrylate intermediate (k(obs) = 0.96 +- 0.02 and 0.38 +- 0.01 mM(-1) s(-1), respectively, at 24  C) with concomitant loss of H(2)O and H(2)S and without detectable accumulation of the external aldimine or other intermediates.	Water	218-223	cystathionine beta-synthase	Homo sapiens	46-49
23124209-4	2012	The reactions of L-serine and L-cysteine with CBS resulted in the formation of a common aminoacrylate intermediate (k(obs) = 0.96 +- 0.02 and 0.38 +- 0.01 mM(-1) s(-1), respectively, at 24  C) with concomitant loss of H(2)O and H(2)S and without detectable accumulation of the external aldimine or other intermediates.	Hydrogen Sulfide	228-233	cystathionine beta-synthase	Homo sapiens	46-49
23124209-4	2012	The reactions of L-serine and L-cysteine with CBS resulted in the formation of a common aminoacrylate intermediate (k(obs) = 0.96 +- 0.02 and 0.38 +- 0.01 mM(-1) s(-1), respectively, at 24  C) with concomitant loss of H(2)O and H(2)S and without detectable accumulation of the external aldimine or other intermediates.	aldimine	286-294	cystathionine beta-synthase	Homo sapiens	46-49
23124209-6	2012	In the reverse direction, CBS reacted with cystathionine, forming the aminoacrylate intermediate with k(obs) = 0.38 +- 0.01 mM(-1) s(-1).	Cystathionine	43-56	cystathionine beta-synthase	Homo sapiens	26-29
23124209-6	2012	In the reverse direction, CBS reacted with cystathionine, forming the aminoacrylate intermediate with k(obs) = 0.38 +- 0.01 mM(-1) s(-1).	(Z)-3-aminoacrylate	70-83	cystathionine beta-synthase	Homo sapiens	26-29
23093113-4	2012	Based on high level coupled-cluster (estimated CCSD(T)/CBS) computations it was concluded that benzene is more aromatic/stable than pyridine by 2.2 kcal mol(-1).	pyridine	132-140	cystathionine beta-synthase	Homo sapiens	55-58
22476058-2	2012	The enzymes that produce H(2)S - mainly cystathionine-beta-synthase and cystathionine-gamma-lyase - are expressed in pulmonary and airway tissues.	Hydrogen Sulfide	25-30	cystathionine beta-synthase	Homo sapiens	40-67
22841676-4	2012	It is predominantly formed from L-cysteine by cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).	Cysteine	32-42	cystathionine beta-synthase	Homo sapiens	46-73
23226735-1	2012	Hydrogen sulfide (H(2)S), is a member of the novel family of endogenous gaseous transmitters, termed "gasotransmitters exhibiting diverse physiological activities, and is generated in mammalian tissues mainly by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) in conjunction with cysteine (aspartate) aminotranferase (CAT).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	241-244
23143240-1	2012	Human cystathionine beta-synthase (CBS) is a pyridoxal-5"-phosphate-dependent hemeprotein, whose catalytic activity is regulated by S-adenosylmethionine.	S-Adenosylmethionine	132-152	cystathionine beta-synthase	Homo sapiens	6-33
23143240-1	2012	Human cystathionine beta-synthase (CBS) is a pyridoxal-5"-phosphate-dependent hemeprotein, whose catalytic activity is regulated by S-adenosylmethionine.	S-Adenosylmethionine	132-152	cystathionine beta-synthase	Homo sapiens	35-38
23143240-2	2012	CBS catalyzes the beta-replacement reaction of homocysteine (Hcy) with serine to yield cystathionine.	Homocysteine	47-59	cystathionine beta-synthase	Homo sapiens	0-3
23143240-2	2012	CBS catalyzes the beta-replacement reaction of homocysteine (Hcy) with serine to yield cystathionine.	Homocysteine	61-64	cystathionine beta-synthase	Homo sapiens	0-3
23143240-2	2012	CBS catalyzes the beta-replacement reaction of homocysteine (Hcy) with serine to yield cystathionine.	Serine	71-77	cystathionine beta-synthase	Homo sapiens	0-3
23143240-2	2012	CBS catalyzes the beta-replacement reaction of homocysteine (Hcy) with serine to yield cystathionine.	Cystathionine	87-100	cystathionine beta-synthase	Homo sapiens	0-3
23143240-3	2012	CBS is a key regulator of plasma levels of the thrombogenic Hcy and deficiency in CBS is the single most common cause of homocystinuria, an inherited metabolic disorder of sulfur amino acids.	Amino Acids, Sulfur	172-190	cystathionine beta-synthase	Homo sapiens	0-3
22977242-0	2012	Allosteric communication between the pyridoxal 5"-phosphate (PLP) and heme sites in the H2S generator human cystathionine beta-synthase.	Heme	70-74	cystathionine beta-synthase	Homo sapiens	108-135
22977242-0	2012	Allosteric communication between the pyridoxal 5"-phosphate (PLP) and heme sites in the H2S generator human cystathionine beta-synthase.	Hydrogen Sulfide	88-91	cystathionine beta-synthase	Homo sapiens	108-135
22977242-1	2012	Human cystathionine beta-synthase (CBS) is a unique pyridoxal 5"-phosphate (PLP)-dependent enzyme that has a regulatory heme cofactor.	Heme	120-124	cystathionine beta-synthase	Homo sapiens	6-33
23226735-1	2012	Hydrogen sulfide (H(2)S), is a member of the novel family of endogenous gaseous transmitters, termed "gasotransmitters exhibiting diverse physiological activities, and is generated in mammalian tissues mainly by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) in conjunction with cysteine (aspartate) aminotranferase (CAT).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	212-239
23226735-1	2012	Hydrogen sulfide (H(2)S), is a member of the novel family of endogenous gaseous transmitters, termed "gasotransmitters exhibiting diverse physiological activities, and is generated in mammalian tissues mainly by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) in conjunction with cysteine (aspartate) aminotranferase (CAT).	Hydrogen Sulfide	18-23	cystathionine beta-synthase	Homo sapiens	212-239
23226735-1	2012	Hydrogen sulfide (H(2)S), is a member of the novel family of endogenous gaseous transmitters, termed "gasotransmitters exhibiting diverse physiological activities, and is generated in mammalian tissues mainly by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) in conjunction with cysteine (aspartate) aminotranferase (CAT).	Hydrogen Sulfide	18-23	cystathionine beta-synthase	Homo sapiens	241-244
23226735-9	2012	Pretreatment with the CBS inhibitor aminooxyacetic acid (AOAA) or CBS small interfering RNA (siRNA) decreased LPS-enhanced H(2)S production.	Aminooxyacetic Acid	36-55	cystathionine beta-synthase	Homo sapiens	22-25
23226735-9	2012	Pretreatment with the CBS inhibitor aminooxyacetic acid (AOAA) or CBS small interfering RNA (siRNA) decreased LPS-enhanced H(2)S production.	Aminooxyacetic Acid	57-61	cystathionine beta-synthase	Homo sapiens	22-25
23226735-9	2012	Pretreatment with the CBS inhibitor aminooxyacetic acid (AOAA) or CBS small interfering RNA (siRNA) decreased LPS-enhanced H(2)S production.	Hydrogen Sulfide	123-128	cystathionine beta-synthase	Homo sapiens	22-25
23226735-9	2012	Pretreatment with the CBS inhibitor aminooxyacetic acid (AOAA) or CBS small interfering RNA (siRNA) decreased LPS-enhanced H(2)S production.	Hydrogen Sulfide	123-128	cystathionine beta-synthase	Homo sapiens	66-69
22402366-4	2012	We further demonstrated that four of these genes, CXCR3, PGDS, GPR98 and CBS, consistently responded to cycloleucine treatment in additional experiments over a range of concentrations.	Cycloleucine	104-116	cystathionine beta-synthase	Homo sapiens	73-76
23020085-4	2012	However, the bystander effects were increased when the irradiated cells were pretreated with an inhibitor of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), the synthases of endogenous hydrogen sulfide (H(2)S).	Hydrogen Sulfide	208-224	cystathionine beta-synthase	Homo sapiens	109-136
23059761-2	2012	H(2)S is biosynthesized in mammalian tissues by cystathionine-beta-synthase and cystathionine-gamma-lyase.	Hydrogen Sulfide	0-5	cystathionine beta-synthase	Homo sapiens	48-75
23117410-6	2012	We found that CBS depletion induces mild mitochondrial dysfunction and increases the sensitivity of endothelial cells to homocysteine, a known inducer of endothelial cell senescence and an established risk factor for vascular disease.	Homocysteine	121-133	cystathionine beta-synthase	Homo sapiens	14-17
22891245-2	2012	CBS is a trans-sulfuration enzyme critical for the reduced glutathione (GSH) synthesis and GSH-dependent defense against oxidative stress.	Glutathione	59-70	cystathionine beta-synthase	Homo sapiens	0-3
22891245-2	2012	CBS is a trans-sulfuration enzyme critical for the reduced glutathione (GSH) synthesis and GSH-dependent defense against oxidative stress.	Glutathione	72-75	cystathionine beta-synthase	Homo sapiens	0-3
22891245-2	2012	CBS is a trans-sulfuration enzyme critical for the reduced glutathione (GSH) synthesis and GSH-dependent defense against oxidative stress.	Glutathione	91-94	cystathionine beta-synthase	Homo sapiens	0-3
22891245-9	2012	Decreasing the GSH/GSSG ratio by adding GSSG to cellular extracts also dissociated LanCL1 from CBS.	Glutathione	15-18	cystathionine beta-synthase	Homo sapiens	95-98
22891245-9	2012	Decreasing the GSH/GSSG ratio by adding GSSG to cellular extracts also dissociated LanCL1 from CBS.	Glutathione Disulfide	19-23	cystathionine beta-synthase	Homo sapiens	95-98
22891245-9	2012	Decreasing the GSH/GSSG ratio by adding GSSG to cellular extracts also dissociated LanCL1 from CBS.	Glutathione Disulfide	40-44	cystathionine beta-synthase	Homo sapiens	95-98
22780428-6	2012	At RCCSD(T)/CBS level, the enthalpic barrier to form cis-ONO-NO2 is 1.9 kcal/mol, whereas the enthalpic barrier to form trans-ONO-NO2 is 13.2 kcal/mol, in agreement with the GVB-RCI result.	cis-ono-no2	53-64	cystathionine beta-synthase	Homo sapiens	12-15
23193672-2	2012	In mammalians, H2S is mainly synthesized by two proteases, cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).	Hydrogen Sulfide	15-18	cystathionine beta-synthase	Homo sapiens	59-86
23050059-2	2012	In the application to the intermolecular interaction energy between insulin dimer and 4"-hydroxyacetanilide at the MP2/CBS level, we use the fragment molecular orbital method for the calculation of the entire complex assigned to the lowest layer in three-layer ONIOM.	4"-hydroxyacetanilide	86-107	cystathionine beta-synthase	Homo sapiens	119-122
22738154-0	2012	Effect of the disease-causing R266K mutation on the heme and PLP environments of human cystathionine beta-synthase.	Heme	52-56	cystathionine beta-synthase	Homo sapiens	87-114
22738154-1	2012	Cystathionine beta-synthase (CBS) is an essential pyridoxal 5"-phosphate (PLP)-dependent enzyme of the transsulfuration pathway that condenses serine with homocysteine to form cystathionine; intriguingly, human CBS also contains a heme b cofactor of unknown function.	Pyridoxal Phosphate	50-72	cystathionine beta-synthase	Homo sapiens	0-27
22738154-1	2012	Cystathionine beta-synthase (CBS) is an essential pyridoxal 5"-phosphate (PLP)-dependent enzyme of the transsulfuration pathway that condenses serine with homocysteine to form cystathionine; intriguingly, human CBS also contains a heme b cofactor of unknown function.	Pyridoxal Phosphate	50-72	cystathionine beta-synthase	Homo sapiens	29-32
22738154-1	2012	Cystathionine beta-synthase (CBS) is an essential pyridoxal 5"-phosphate (PLP)-dependent enzyme of the transsulfuration pathway that condenses serine with homocysteine to form cystathionine; intriguingly, human CBS also contains a heme b cofactor of unknown function.	Pyridoxal Phosphate	74-77	cystathionine beta-synthase	Homo sapiens	0-27
22738154-1	2012	Cystathionine beta-synthase (CBS) is an essential pyridoxal 5"-phosphate (PLP)-dependent enzyme of the transsulfuration pathway that condenses serine with homocysteine to form cystathionine; intriguingly, human CBS also contains a heme b cofactor of unknown function.	Pyridoxal Phosphate	74-77	cystathionine beta-synthase	Homo sapiens	29-32
22738154-1	2012	Cystathionine beta-synthase (CBS) is an essential pyridoxal 5"-phosphate (PLP)-dependent enzyme of the transsulfuration pathway that condenses serine with homocysteine to form cystathionine; intriguingly, human CBS also contains a heme b cofactor of unknown function.	Pyridoxal Phosphate	74-77	cystathionine beta-synthase	Homo sapiens	211-214
22738154-1	2012	Cystathionine beta-synthase (CBS) is an essential pyridoxal 5"-phosphate (PLP)-dependent enzyme of the transsulfuration pathway that condenses serine with homocysteine to form cystathionine; intriguingly, human CBS also contains a heme b cofactor of unknown function.	Serine	143-149	cystathionine beta-synthase	Homo sapiens	0-27
22738154-1	2012	Cystathionine beta-synthase (CBS) is an essential pyridoxal 5"-phosphate (PLP)-dependent enzyme of the transsulfuration pathway that condenses serine with homocysteine to form cystathionine; intriguingly, human CBS also contains a heme b cofactor of unknown function.	Serine	143-149	cystathionine beta-synthase	Homo sapiens	29-32
22738154-1	2012	Cystathionine beta-synthase (CBS) is an essential pyridoxal 5"-phosphate (PLP)-dependent enzyme of the transsulfuration pathway that condenses serine with homocysteine to form cystathionine; intriguingly, human CBS also contains a heme b cofactor of unknown function.	Homocysteine	155-167	cystathionine beta-synthase	Homo sapiens	0-27
22738154-1	2012	Cystathionine beta-synthase (CBS) is an essential pyridoxal 5"-phosphate (PLP)-dependent enzyme of the transsulfuration pathway that condenses serine with homocysteine to form cystathionine; intriguingly, human CBS also contains a heme b cofactor of unknown function.	Homocysteine	155-167	cystathionine beta-synthase	Homo sapiens	29-32
22738154-1	2012	Cystathionine beta-synthase (CBS) is an essential pyridoxal 5"-phosphate (PLP)-dependent enzyme of the transsulfuration pathway that condenses serine with homocysteine to form cystathionine; intriguingly, human CBS also contains a heme b cofactor of unknown function.	Cystathionine	176-189	cystathionine beta-synthase	Homo sapiens	0-27
22738154-1	2012	Cystathionine beta-synthase (CBS) is an essential pyridoxal 5"-phosphate (PLP)-dependent enzyme of the transsulfuration pathway that condenses serine with homocysteine to form cystathionine; intriguingly, human CBS also contains a heme b cofactor of unknown function.	Cystathionine	176-189	cystathionine beta-synthase	Homo sapiens	29-32
22738154-1	2012	Cystathionine beta-synthase (CBS) is an essential pyridoxal 5"-phosphate (PLP)-dependent enzyme of the transsulfuration pathway that condenses serine with homocysteine to form cystathionine; intriguingly, human CBS also contains a heme b cofactor of unknown function.	Cystathionine	176-189	cystathionine beta-synthase	Homo sapiens	211-214
22689570-4	2012	Molecular modeling, based on the structural coordinates of the homologous ClC-5 and CmClC proteins and in silico docking, suggest that NAD(+) binds with the adenine base deep in a cleft formed by ClC-1 intracellular cystathionine beta-synthase domains, and the nicotinamide base interacts with the membrane-embedded channel domain.	NAD	135-141	cystathionine beta-synthase	Homo sapiens	216-243
22665368-8	2012	These studies suggest that SNPs in CBS and MTRR have sex-specific associations with aberrant methylation in the lung epithelium of smokers that could be mediated by the affected one-carbon metabolism and transsulfuration in the cells.	Carbon	182-188	cystathionine beta-synthase	Homo sapiens	35-38
22689570-4	2012	Molecular modeling, based on the structural coordinates of the homologous ClC-5 and CmClC proteins and in silico docking, suggest that NAD(+) binds with the adenine base deep in a cleft formed by ClC-1 intracellular cystathionine beta-synthase domains, and the nicotinamide base interacts with the membrane-embedded channel domain.	Adenine	157-164	cystathionine beta-synthase	Homo sapiens	216-243
22689570-5	2012	Consistent with predictions from the models, mutation of residues in cystathionine beta-synthase and channel domains either attenuated (G200R, T636A, H847A) or abrogated (L848A) the effect of NAD(+).	NAD	192-198	cystathionine beta-synthase	Homo sapiens	69-96
22781905-2	2012	H(2)S is predominantly formed from Cys or its derivatives by the enzymes cystathionine beta-synthase and cystathionine gamma-lyase.	Hydrogen Sulfide	0-5	cystathionine beta-synthase	Homo sapiens	73-100
22781905-2	2012	H(2)S is predominantly formed from Cys or its derivatives by the enzymes cystathionine beta-synthase and cystathionine gamma-lyase.	Cysteine	35-38	cystathionine beta-synthase	Homo sapiens	73-100
22331189-5	2012	Recent studies using metabolomics revealed that CO inhibits cystathionine beta-synthase (CBS), which generates H(2)S, another gaseous mediator.	Carbon Monoxide	48-50	cystathionine beta-synthase	Homo sapiens	60-87
22517358-2	2012	Endogenously, H(2)S is produced as a metabolite of homocysteine (Hcy) by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST).	Hydrogen Sulfide	14-19	cystathionine beta-synthase	Homo sapiens	73-100
22517358-2	2012	Endogenously, H(2)S is produced as a metabolite of homocysteine (Hcy) by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST).	Homocysteine	51-63	cystathionine beta-synthase	Homo sapiens	73-100
22517358-2	2012	Endogenously, H(2)S is produced as a metabolite of homocysteine (Hcy) by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3MST).	Homocysteine	65-68	cystathionine beta-synthase	Homo sapiens	73-100
21938399-7	2012	CBS protein level and activity increased with incubation time, upon stimulation, and similar to intracellular homocysteine, depending on intra- and extracellular homocysteine and glutathione concentrations.	Homocysteine	162-174	cystathionine beta-synthase	Homo sapiens	0-3
21938399-7	2012	CBS protein level and activity increased with incubation time, upon stimulation, and similar to intracellular homocysteine, depending on intra- and extracellular homocysteine and glutathione concentrations.	Glutathione	179-190	cystathionine beta-synthase	Homo sapiens	0-3
22016355-3	2012	It is mainly synthesized by 2 enzymes, including cystathionine beta-synthase and cystathionine gamma-lysase, which utilize L-cysteine as substrate to produce H(2)S.	Cysteine	123-133	cystathionine beta-synthase	Homo sapiens	49-76
22016355-3	2012	It is mainly synthesized by 2 enzymes, including cystathionine beta-synthase and cystathionine gamma-lysase, which utilize L-cysteine as substrate to produce H(2)S.	Hydrogen Sulfide	158-163	cystathionine beta-synthase	Homo sapiens	49-76
22946297-1	2012	The work is dedicated to creation of the mathematical model of folate-dependent one-carbon unit metabolism (FOCM) and study of its function in human placenta under homocysteine load and the most common mutations in the genes of methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS).	Folic Acid	63-69	cystathionine beta-synthase	Homo sapiens	276-303
22484094-3	2012	Increased levels of the nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) have been associated with HHcy, and may contribute, at least in part, for the homocysteine-induced endothelial dysfunction, but whether cystathionine beta-synthase (CBS) deficiency is associated with increased ADMA has hardly been investigated.	Nitric Oxide	24-36	cystathionine beta-synthase	Homo sapiens	227-254
22484094-3	2012	Increased levels of the nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) have been associated with HHcy, and may contribute, at least in part, for the homocysteine-induced endothelial dysfunction, but whether cystathionine beta-synthase (CBS) deficiency is associated with increased ADMA has hardly been investigated.	dimethylarginine	67-83	cystathionine beta-synthase	Homo sapiens	227-254
22484094-3	2012	Increased levels of the nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA) have been associated with HHcy, and may contribute, at least in part, for the homocysteine-induced endothelial dysfunction, but whether cystathionine beta-synthase (CBS) deficiency is associated with increased ADMA has hardly been investigated.	N,N-dimethylarginine	85-89	cystathionine beta-synthase	Homo sapiens	227-254
21517828-1	2012	Homocystinuria due to cystathionine beta synthase (CBS) deficiency results in elevated plasma homocysteine and methionine levels, which are associated with multiple organ pathologies, including vascular, respiratory, musculoskeletal, nervous, and ocular tissues.	Homocysteine	94-106	cystathionine beta-synthase	Homo sapiens	22-49
21517828-1	2012	Homocystinuria due to cystathionine beta synthase (CBS) deficiency results in elevated plasma homocysteine and methionine levels, which are associated with multiple organ pathologies, including vascular, respiratory, musculoskeletal, nervous, and ocular tissues.	Methionine	111-121	cystathionine beta-synthase	Homo sapiens	22-49
22391326-5	2012	Thus, down regulation of CBS during early-onset preeclampsia may result in less H(2)S-production and may aid in the anti-angiogenic state.	Hydrogen Sulfide	80-85	cystathionine beta-synthase	Homo sapiens	25-28
22510106-1	2012	Association energies of the acetate ion with cationic amines bearing one to three methyl groups were calculated in the range of -14 to -17 kcal/mol in aqueous solution by means of the IEF-PCM method at the CCSD(T)/CBS//MP2/aug-cc-pvdz and DFT/B97D/CBS//B97D/aug-cc-pvtz levels.	Acetates	28-35	cystathionine beta-synthase	Homo sapiens	214-217
22510106-1	2012	Association energies of the acetate ion with cationic amines bearing one to three methyl groups were calculated in the range of -14 to -17 kcal/mol in aqueous solution by means of the IEF-PCM method at the CCSD(T)/CBS//MP2/aug-cc-pvdz and DFT/B97D/CBS//B97D/aug-cc-pvtz levels.	Acetates	28-35	cystathionine beta-synthase	Homo sapiens	248-251
22418695-5	2012	The calculations at all-electron CCSD(T)/CBS level of theory indicate that the barriers for all reactions (forward and reverse) are greater than 100 kJ mol(-1), meaning that the chemical reactivity of the reactants is limited in the absence of hydrogen tunnelling.	Hydrogen	244-252	cystathionine beta-synthase	Homo sapiens	41-44
21679296-4	2012	The expression and enzymatic activity of the H(2)S synthesizing enzymes cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) were determined by Western blot and zinc-trap spectrophotometry, respectively.	Hydrogen Sulfide	45-50	cystathionine beta-synthase	Homo sapiens	72-99
22555844-8	2012	Moreover, overexpression of cystathionine beta-synthase (a main H(2)S-synthesizing enzyme in the brain) elevated the Hsp90 protein level and suppressed 6-OHDA-induced ER stress.	Oxidopamine	152-158	cystathionine beta-synthase	Homo sapiens	28-55
26105277-3	2012	It is produced from L-cysteine or L-methionine via the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Cysteine	20-30	cystathionine beta-synthase	Homo sapiens	63-90
26105277-3	2012	It is produced from L-cysteine or L-methionine via the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Cysteine	20-30	cystathionine beta-synthase	Homo sapiens	92-95
26105277-3	2012	It is produced from L-cysteine or L-methionine via the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Methionine	34-46	cystathionine beta-synthase	Homo sapiens	63-90
26105277-3	2012	It is produced from L-cysteine or L-methionine via the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Methionine	34-46	cystathionine beta-synthase	Homo sapiens	92-95
26105277-18	2012	CBS and CSE, the enzymes involved in the production of H2S, were down-regulated in SHR rats and, as a consequence the H2S production was significantly reduced.	Hydrogen Sulfide	55-58	cystathionine beta-synthase	Homo sapiens	0-3
26105277-18	2012	CBS and CSE, the enzymes involved in the production of H2S, were down-regulated in SHR rats and, as a consequence the H2S production was significantly reduced.	Hydrogen Sulfide	118-121	cystathionine beta-synthase	Homo sapiens	0-3
22612060-7	2012	Interestingly, the presence of the CBS allosteric activator, S-adenosylmethionine (AdoMet), increased the rate of cleavage of the wild type and the AdoMet-responsive mutants, while the proteolytic rate of the AdoMet-unresponsive mutants was not significantly changed.	S-Adenosylmethionine	61-81	cystathionine beta-synthase	Homo sapiens	35-38
22612060-7	2012	Interestingly, the presence of the CBS allosteric activator, S-adenosylmethionine (AdoMet), increased the rate of cleavage of the wild type and the AdoMet-responsive mutants, while the proteolytic rate of the AdoMet-unresponsive mutants was not significantly changed.	S-Adenosylmethionine	83-89	cystathionine beta-synthase	Homo sapiens	35-38
22267502-7	2012	This large class included alleles rescued by elevated levels of the cofactor vitamin B6, but also alleles rescued by elevated heme, a second CBS cofactor.	Heme	126-130	cystathionine beta-synthase	Homo sapiens	141-144
22267502-9	2012	Production of the critical antioxidant glutathione through the CBS pathway was greatly decreased when CBS function was restricted through genetic, cofactor, or substrate restriction, a metabolic consequence with implications for treatment.	Glutathione	39-50	cystathionine beta-synthase	Homo sapiens	63-66
22267502-9	2012	Production of the critical antioxidant glutathione through the CBS pathway was greatly decreased when CBS function was restricted through genetic, cofactor, or substrate restriction, a metabolic consequence with implications for treatment.	Glutathione	39-50	cystathionine beta-synthase	Homo sapiens	102-105
22333527-1	2012	Cystathionine beta-synthase (CBS), a heme-containing pyridoxal-5-phosphate (PLP)-dependent enzyme, catalyzes the condensation of serine and homocysteine to yield cystathionine.	Pyridoxal Phosphate	53-74	cystathionine beta-synthase	Homo sapiens	0-27
22333527-1	2012	Cystathionine beta-synthase (CBS), a heme-containing pyridoxal-5-phosphate (PLP)-dependent enzyme, catalyzes the condensation of serine and homocysteine to yield cystathionine.	Pyridoxal Phosphate	53-74	cystathionine beta-synthase	Homo sapiens	29-32
22333527-1	2012	Cystathionine beta-synthase (CBS), a heme-containing pyridoxal-5-phosphate (PLP)-dependent enzyme, catalyzes the condensation of serine and homocysteine to yield cystathionine.	Serine	129-135	cystathionine beta-synthase	Homo sapiens	0-27
22333527-1	2012	Cystathionine beta-synthase (CBS), a heme-containing pyridoxal-5-phosphate (PLP)-dependent enzyme, catalyzes the condensation of serine and homocysteine to yield cystathionine.	Serine	129-135	cystathionine beta-synthase	Homo sapiens	29-32
22333527-1	2012	Cystathionine beta-synthase (CBS), a heme-containing pyridoxal-5-phosphate (PLP)-dependent enzyme, catalyzes the condensation of serine and homocysteine to yield cystathionine.	Homocysteine	140-152	cystathionine beta-synthase	Homo sapiens	0-27
22333527-1	2012	Cystathionine beta-synthase (CBS), a heme-containing pyridoxal-5-phosphate (PLP)-dependent enzyme, catalyzes the condensation of serine and homocysteine to yield cystathionine.	Homocysteine	140-152	cystathionine beta-synthase	Homo sapiens	29-32
22333527-1	2012	Cystathionine beta-synthase (CBS), a heme-containing pyridoxal-5-phosphate (PLP)-dependent enzyme, catalyzes the condensation of serine and homocysteine to yield cystathionine.	Cystathionine	162-175	cystathionine beta-synthase	Homo sapiens	0-27
22333527-1	2012	Cystathionine beta-synthase (CBS), a heme-containing pyridoxal-5-phosphate (PLP)-dependent enzyme, catalyzes the condensation of serine and homocysteine to yield cystathionine.	Cystathionine	162-175	cystathionine beta-synthase	Homo sapiens	29-32
22808324-7	2012	Cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) are well known as H(2)S-producing enzymes.	Hydrogen Sulfide	88-93	cystathionine beta-synthase	Homo sapiens	0-27
22331189-5	2012	Recent studies using metabolomics revealed that CO inhibits cystathionine beta-synthase (CBS), which generates H(2)S, another gaseous mediator.	Carbon Monoxide	48-50	cystathionine beta-synthase	Homo sapiens	89-92
22331189-5	2012	Recent studies using metabolomics revealed that CO inhibits cystathionine beta-synthase (CBS), which generates H(2)S, another gaseous mediator.	Hydrogen Sulfide	111-116	cystathionine beta-synthase	Homo sapiens	60-87
22331189-5	2012	Recent studies using metabolomics revealed that CO inhibits cystathionine beta-synthase (CBS), which generates H(2)S, another gaseous mediator.	Hydrogen Sulfide	111-116	cystathionine beta-synthase	Homo sapiens	89-92
22331189-6	2012	The CO-dependent CBS inhibition may impact on the remethylation cycle and related metabolic pathways including the methionine salvage pathway and polyamine synthesis.	Methionine	115-125	cystathionine beta-synthase	Homo sapiens	17-20
22331189-6	2012	The CO-dependent CBS inhibition may impact on the remethylation cycle and related metabolic pathways including the methionine salvage pathway and polyamine synthesis.	Polyamines	146-155	cystathionine beta-synthase	Homo sapiens	17-20
22167178-9	2012	Furthermore, activation increases the capacity of T cells to make H(2)S via increased expression of cystathionine gamma-lyase and cystathionine beta-synthase.	Hydrogen Sulfide	66-71	cystathionine beta-synthase	Homo sapiens	130-157
21917271-5	2012	Significant associations between CBS T833C genetic polymorphism and risk of stroke were observed in most genetic models (OR=1.57, 95% CI=1.02-2.41, p=0.039 for TC+CC vs. TT; OR=1.79, 95% CI=1.14-2.82, p=0.012 for CC vs. TT; OR=1.56, 95% CI=1.01-2.40, p=0.044 for TC vs. TT).	Technetium	160-162	cystathionine beta-synthase	Homo sapiens	33-36
22310774-0	2012	Characterization of hydrogen sulfide and its synthases, cystathionine beta-synthase and cystathionine gamma-lyase, in human prostatic tissue and cells.	Hydrogen Sulfide	20-36	cystathionine beta-synthase	Homo sapiens	56-83
22310774-1	2012	OBJECTIVE: To investigate hydrogen sulfide and its synthases, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), in human prostatic tissue and cells.	Hydrogen Sulfide	26-42	cystathionine beta-synthase	Homo sapiens	62-89
22310774-1	2012	OBJECTIVE: To investigate hydrogen sulfide and its synthases, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), in human prostatic tissue and cells.	Hydrogen Sulfide	26-42	cystathionine beta-synthase	Homo sapiens	91-94
22310774-3	2012	Western blot and a sulfur-sensitive electrode were used to evaluate the expression levels and catalytic activity of CBS and CSE.	Sulfur	19-25	cystathionine beta-synthase	Homo sapiens	116-119
22310774-7	2012	Cell activity and CBS/CSE protein levels were greatest in the androgen-dependent prostate cancer cell LNCaP among all cells and downregulated by dihydrotestosterone.	Dihydrotestosterone	145-164	cystathionine beta-synthase	Homo sapiens	18-21
22036943-3	2012	H(2)S is produced by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulphurtransferase (MST).	Hydrogen Sulfide	0-5	cystathionine beta-synthase	Homo sapiens	21-48
22036943-3	2012	H(2)S is produced by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulphurtransferase (MST).	Hydrogen Sulfide	0-5	cystathionine beta-synthase	Homo sapiens	50-53
21917271-5	2012	Significant associations between CBS T833C genetic polymorphism and risk of stroke were observed in most genetic models (OR=1.57, 95% CI=1.02-2.41, p=0.039 for TC+CC vs. TT; OR=1.79, 95% CI=1.14-2.82, p=0.012 for CC vs. TT; OR=1.56, 95% CI=1.01-2.40, p=0.044 for TC vs. TT).	Technetium	263-265	cystathionine beta-synthase	Homo sapiens	33-36
23281754-9	2012	Hypoxia-induced pulmonary hypertension was significantly reduced by administration of NaHS but this protective effect was largely abolished by D, L-propargylglycerine, an inhibitor of CSE.	d, l-propargylglycerine	143-166	cystathionine beta-synthase	Homo sapiens	184-187
22102329-3	2012	Binding energy for the most stable configuration of the C(2)H(4)-C(2)H(4) complex was calculated at the CCSD(T)/CBS level of theory.	c(2)h(4)	56-64	cystathionine beta-synthase	Homo sapiens	112-115
22102329-3	2012	Binding energy for the most stable configuration of the C(2)H(4)-C(2)H(4) complex was calculated at the CCSD(T)/CBS level of theory.	c(2)h(4)	65-73	cystathionine beta-synthase	Homo sapiens	112-115
22120434-9	2012	During hypoxia there were concurrent increases in H(2)S production, which could be prevented by CBS inhibitor, indicating the endogenous source of the gas.	Hydrogen Sulfide	50-55	cystathionine beta-synthase	Homo sapiens	96-99
22120434-10	2012	cAMP concentration, but not cGMP and NO(x), correlated with CBS activity.	Cyclic AMP	0-4	cystathionine beta-synthase	Homo sapiens	60-63
22120434-12	2012	In conclusion, hypoxia activates H(2)S endogenous production through the CBS-H(2)S pathway in the AVPO, having a cryogenic effect.	Hydrogen Sulfide	33-38	cystathionine beta-synthase	Homo sapiens	73-76
22120434-12	2012	In conclusion, hypoxia activates H(2)S endogenous production through the CBS-H(2)S pathway in the AVPO, having a cryogenic effect.	Hydrogen Sulfide	77-82	cystathionine beta-synthase	Homo sapiens	73-76
21957013-3	2012	The protective effect provided by FA suggests that the genes involved in folate metabolism, such as cystathionine beta-synthase (CBS), warrant further investigation.	Folic Acid	73-79	cystathionine beta-synthase	Homo sapiens	100-127
21957013-3	2012	The protective effect provided by FA suggests that the genes involved in folate metabolism, such as cystathionine beta-synthase (CBS), warrant further investigation.	Folic Acid	73-79	cystathionine beta-synthase	Homo sapiens	129-132
22470444-9	2012	The combined effect of MTHFR C677T, MS A2756G and CBS 844ins68 genotypes for plasma homocysteine levels was additive (p value &lt;0.001).	Homocysteine	84-96	cystathionine beta-synthase	Homo sapiens	50-53
22680638-2	2012	H(2)S is biosynthesized in mammalian tissues by both non-enzymatic processes and several enzymatic pathways ensured by cystathionine-beta-synthase and cystathionine-gamma-lyase.	Hydrogen Sulfide	0-5	cystathionine beta-synthase	Homo sapiens	119-146
23152928-3	2012	Cystathionine-beta-synthase (CBS) functions in the folate metabolism pathway, which is intricately linked to methylation of genomic DNA.	Folic Acid	51-57	cystathionine beta-synthase	Homo sapiens	0-27
23152928-3	2012	Cystathionine-beta-synthase (CBS) functions in the folate metabolism pathway, which is intricately linked to methylation of genomic DNA.	Folic Acid	51-57	cystathionine beta-synthase	Homo sapiens	29-32
23152928-8	2012	Treatment with 5-aza-2"-deoxycytidine and/or trichostatin A reversed methylation and restored CBS mRNA expression indicating a direct effect.	Decitabine	15-37	cystathionine beta-synthase	Homo sapiens	94-97
23152928-8	2012	Treatment with 5-aza-2"-deoxycytidine and/or trichostatin A reversed methylation and restored CBS mRNA expression indicating a direct effect.	trichostatin A	45-59	cystathionine beta-synthase	Homo sapiens	94-97
23152928-13	2012	CONCLUSION: A novel finding from this study is that the folate metabolism enzyme CBS mRNA levels are frequently downregulated through CpG methylation of the CBS gene in gastric cancer and CRC, suggesting that CBS functions as a tumor suppressor gene.	Folic Acid	56-62	cystathionine beta-synthase	Homo sapiens	81-84
23152928-13	2012	CONCLUSION: A novel finding from this study is that the folate metabolism enzyme CBS mRNA levels are frequently downregulated through CpG methylation of the CBS gene in gastric cancer and CRC, suggesting that CBS functions as a tumor suppressor gene.	Folic Acid	56-62	cystathionine beta-synthase	Homo sapiens	157-160
23152928-13	2012	CONCLUSION: A novel finding from this study is that the folate metabolism enzyme CBS mRNA levels are frequently downregulated through CpG methylation of the CBS gene in gastric cancer and CRC, suggesting that CBS functions as a tumor suppressor gene.	Folic Acid	56-62	cystathionine beta-synthase	Homo sapiens	157-160
22002135-1	2011	Cystathionine  beta synthase gene (CbetaS)  catalyzes the condensation of homocysteine with serine, forming cystathionine  by the transsulfuration pathway.	Homocysteine	74-86	cystathionine beta-synthase	Homo sapiens	0-28
22253703-1	2012	BACKGROUND: The cystathionine beta-synthase (CBS) gene, located on human chromosome 21q22.3, is a good candidate for playing a role in the Down Syndrome (DS) cognitive profile: it is overexpressed in the brain of individuals with DS, and it encodes a key enzyme of sulfur-containing amino acid (SAA) metabolism, a pathway important for several brain physiological processes.	Sulfur	265-271	cystathionine beta-synthase	Homo sapiens	16-43
22253703-1	2012	BACKGROUND: The cystathionine beta-synthase (CBS) gene, located on human chromosome 21q22.3, is a good candidate for playing a role in the Down Syndrome (DS) cognitive profile: it is overexpressed in the brain of individuals with DS, and it encodes a key enzyme of sulfur-containing amino acid (SAA) metabolism, a pathway important for several brain physiological processes.	Sulfur	265-271	cystathionine beta-synthase	Homo sapiens	45-48
22253703-1	2012	BACKGROUND: The cystathionine beta-synthase (CBS) gene, located on human chromosome 21q22.3, is a good candidate for playing a role in the Down Syndrome (DS) cognitive profile: it is overexpressed in the brain of individuals with DS, and it encodes a key enzyme of sulfur-containing amino acid (SAA) metabolism, a pathway important for several brain physiological processes.	saa	295-298	cystathionine beta-synthase	Homo sapiens	16-43
22253703-1	2012	BACKGROUND: The cystathionine beta-synthase (CBS) gene, located on human chromosome 21q22.3, is a good candidate for playing a role in the Down Syndrome (DS) cognitive profile: it is overexpressed in the brain of individuals with DS, and it encodes a key enzyme of sulfur-containing amino acid (SAA) metabolism, a pathway important for several brain physiological processes.	saa	295-298	cystathionine beta-synthase	Homo sapiens	45-48
24278674-1	2012	Hydrogen sulfide (H2S) is a well-known toxic gas that is synthesized in the human body from the amino acids cystathionine, homocysteine, and cysteine by the action of at least two distinct enzymes: cystathionine-gamma-lyase and cystathionine-beta-synthase.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	228-255
24278674-1	2012	Hydrogen sulfide (H2S) is a well-known toxic gas that is synthesized in the human body from the amino acids cystathionine, homocysteine, and cysteine by the action of at least two distinct enzymes: cystathionine-gamma-lyase and cystathionine-beta-synthase.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	228-255
21937432-2	2011	Cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) are well-known as H(2)S-producing enzymes.	Hydrogen Sulfide	88-93	cystathionine beta-synthase	Homo sapiens	0-27
21984168-9	2011	The differences of heats of formation (at 0 K) between the G4 and CBS approaches for the B(n)Si clusters vary in the range of 0.0-4.6 kcal mol(-1).	Silicon	93-95	cystathionine beta-synthase	Homo sapiens	66-69
21975197-8	2011	Associations with change in postmethionine load Hcy levels were found with 5 SNPs in the cystathionine beta-synthase (CBS) gene (FDR-adjusted p &lt; 0.031).	postmethionine	28-42	cystathionine beta-synthase	Homo sapiens	89-116
21975197-8	2011	Associations with change in postmethionine load Hcy levels were found with 5 SNPs in the cystathionine beta-synthase (CBS) gene (FDR-adjusted p &lt; 0.031).	postmethionine	28-42	cystathionine beta-synthase	Homo sapiens	118-121
21975197-8	2011	Associations with change in postmethionine load Hcy levels were found with 5 SNPs in the cystathionine beta-synthase (CBS) gene (FDR-adjusted p &lt; 0.031).	Homocysteine	48-51	cystathionine beta-synthase	Homo sapiens	89-116
21975197-8	2011	Associations with change in postmethionine load Hcy levels were found with 5 SNPs in the cystathionine beta-synthase (CBS) gene (FDR-adjusted p &lt; 0.031).	Homocysteine	48-51	cystathionine beta-synthase	Homo sapiens	118-121
22002135-1	2011	Cystathionine  beta synthase gene (CbetaS)  catalyzes the condensation of homocysteine with serine, forming cystathionine  by the transsulfuration pathway.	Serine	92-98	cystathionine beta-synthase	Homo sapiens	0-28
22002135-1	2011	Cystathionine  beta synthase gene (CbetaS)  catalyzes the condensation of homocysteine with serine, forming cystathionine  by the transsulfuration pathway.	Cystathionine	108-121	cystathionine beta-synthase	Homo sapiens	0-28
21480614-0	2011	Cobalt cystathionine beta-synthase: a cobalt-substituted heme protein with a unique thiolate ligation motif.	thiolate	84-92	cystathionine beta-synthase	Homo sapiens	7-34
21858279-1	2011	The structure of the phenylacetylene-dimer has been elucidated using IR-UV double resonance spectroscopy in combination with high level ab initio calculations at the CCSD(T)/CBS level.	phenylacetylene	21-36	cystathionine beta-synthase	Homo sapiens	174-177
21734104-3	2011	In the central nervous system, hydrogen sulfide (H2S) is a gasotransmitter generated primarily by the enzyme cystathionine-beta-synthase (CBS).	Hydrogen Sulfide	31-47	cystathionine beta-synthase	Homo sapiens	109-136
21734104-3	2011	In the central nervous system, hydrogen sulfide (H2S) is a gasotransmitter generated primarily by the enzyme cystathionine-beta-synthase (CBS).	Hydrogen Sulfide	49-52	cystathionine beta-synthase	Homo sapiens	109-136
21527544-2	2011	We demonstrated in 1996 that cystathionine beta-synthase can produce H(2)S in the brain and that H(2)S facilitates the induction of hippocampal long-term potentiation by enhancing the activity of NMDA receptors.	Hydrogen Sulfide	69-74	cystathionine beta-synthase	Homo sapiens	29-56
21375294-2	2011	The nature of the stabilization for these CT complexes was evaluated on the basis of perturbative NBO calculations and DFT-SAPT/CBS calculations.	ct	42-44	cystathionine beta-synthase	Homo sapiens	128-131
21375294-10	2011	For all CT complexes, the CCSD(T)/CBS and DFT-SAPT/CBS stabilization energies are comparable, and surprisingly, it is true even for very strong CT complexes with stabilization energy close to 50 kcal/mol characteristic by substantial charge transfer (more than 0.3 e).	ct	8-10	cystathionine beta-synthase	Homo sapiens	34-37
21375294-10	2011	For all CT complexes, the CCSD(T)/CBS and DFT-SAPT/CBS stabilization energies are comparable, and surprisingly, it is true even for very strong CT complexes with stabilization energy close to 50 kcal/mol characteristic by substantial charge transfer (more than 0.3 e).	ct	8-10	cystathionine beta-synthase	Homo sapiens	51-54
21658846-6	2011	CBS catalyzes the first of two steps in the transsulfuration pathway that converts homocysteine to cysteine.	Homocysteine	83-95	cystathionine beta-synthase	Homo sapiens	0-3
21658846-6	2011	CBS catalyzes the first of two steps in the transsulfuration pathway that converts homocysteine to cysteine.	Cysteine	87-95	cystathionine beta-synthase	Homo sapiens	0-3
21690209-6	2011	We demonstrated the expression of cystathionine-beta-synthase (CBS) in human placenta at term by RT-PCR and western blot analysis, for the first time, and confirmed its catalytic activity and the accumulation of cysteine and CBS in placental explants cultivated in the presence of elevated Hcy concentrations.	Cysteine	212-220	cystathionine beta-synthase	Homo sapiens	34-61
21690209-6	2011	We demonstrated the expression of cystathionine-beta-synthase (CBS) in human placenta at term by RT-PCR and western blot analysis, for the first time, and confirmed its catalytic activity and the accumulation of cysteine and CBS in placental explants cultivated in the presence of elevated Hcy concentrations.	Homocysteine	290-293	cystathionine beta-synthase	Homo sapiens	34-61
21104445-3	2011	The present study aimed to investigate whether mutations in the methylenetetrahydrofolate reductase (MTHFR) or in the cystathionine beta synthase (CBS) genes are associated with higher levels of homocysteine and the risk of PAD in patients from Brazil.	Homocysteine	195-207	cystathionine beta-synthase	Homo sapiens	118-145
21104445-3	2011	The present study aimed to investigate whether mutations in the methylenetetrahydrofolate reductase (MTHFR) or in the cystathionine beta synthase (CBS) genes are associated with higher levels of homocysteine and the risk of PAD in patients from Brazil.	Homocysteine	195-207	cystathionine beta-synthase	Homo sapiens	147-150
21644223-2	2011	METHODS: The clinical information of 120 X-ALD patients were analyzed and three genetic variants involved in the methionine metabolism, including cystathionine beta-synthase (CBS) c.844_855ins68, 5-methyltetrahydrofolate-homocysteine-S-methyltransferase (MTR) c.2756A to G, and transcobalamin 2 (TC2) c.776 C to G were analyzed by polymerase chain reaction and sequencing.	Methionine	113-123	cystathionine beta-synthase	Homo sapiens	146-173
21480614-8	2011	Co(III) hCBS is slowly reduced to Co(II) hCBS, which contains a 5-coordinate, low-spin, S = 1/2 Co-porphyrin that does not retain the cysteine(thiolate) ligand; this form of Co(II) hCBS binds NO((g)) but not CO((g)).	Carbon Monoxide	208-210	cystathionine beta-synthase	Homo sapiens	8-12
21480614-8	2011	Co(III) hCBS is slowly reduced to Co(II) hCBS, which contains a 5-coordinate, low-spin, S = 1/2 Co-porphyrin that does not retain the cysteine(thiolate) ligand; this form of Co(II) hCBS binds NO((g)) but not CO((g)).	Carbon Monoxide	208-210	cystathionine beta-synthase	Homo sapiens	41-45
21480614-8	2011	Co(III) hCBS is slowly reduced to Co(II) hCBS, which contains a 5-coordinate, low-spin, S = 1/2 Co-porphyrin that does not retain the cysteine(thiolate) ligand; this form of Co(II) hCBS binds NO((g)) but not CO((g)).	Carbon Monoxide	208-210	cystathionine beta-synthase	Homo sapiens	41-45
21480614-9	2011	Co(II) hCBS is reoxidized in the air to form a new Co(III) form, which does not contain a cysteine(thiolate) ligand.	Cysteine	90-98	cystathionine beta-synthase	Homo sapiens	7-11
21480614-9	2011	Co(II) hCBS is reoxidized in the air to form a new Co(III) form, which does not contain a cysteine(thiolate) ligand.	thiolate	99-107	cystathionine beta-synthase	Homo sapiens	7-11
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Heme	73-77	cystathionine beta-synthase	Homo sapiens	26-29
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Heme	73-77	cystathionine beta-synthase	Homo sapiens	109-113
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Heme	73-77	cystathionine beta-synthase	Homo sapiens	175-179
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Iron	106-108	cystathionine beta-synthase	Homo sapiens	26-29
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Iron	106-108	cystathionine beta-synthase	Homo sapiens	109-113
21875066-0	2011	Reversible heme-dependent regulation of human cystathionine beta-synthase by a flavoprotein oxidoreductase.	Heme	11-15	cystathionine beta-synthase	Homo sapiens	46-73
21875066-1	2011	Human CBS is a PLP-dependent enzyme that clears homocysteine, gates the flow of sulfur into glutathione, and contributes to the biogenesis of H(2)S.	Homocysteine	48-60	cystathionine beta-synthase	Homo sapiens	6-9
21875066-1	2011	Human CBS is a PLP-dependent enzyme that clears homocysteine, gates the flow of sulfur into glutathione, and contributes to the biogenesis of H(2)S.	Sulfur	80-86	cystathionine beta-synthase	Homo sapiens	6-9
21875066-1	2011	Human CBS is a PLP-dependent enzyme that clears homocysteine, gates the flow of sulfur into glutathione, and contributes to the biogenesis of H(2)S.	Glutathione	92-103	cystathionine beta-synthase	Homo sapiens	6-9
21875066-1	2011	Human CBS is a PLP-dependent enzyme that clears homocysteine, gates the flow of sulfur into glutathione, and contributes to the biogenesis of H(2)S.	Hydrogen Sulfide	142-147	cystathionine beta-synthase	Homo sapiens	6-9
21875066-2	2011	The presence of a heme cofactor in CBS is enigmatic, and its conversion from the ferric- to ferrous-CO state inhibits enzyme activity.	Heme	18-22	cystathionine beta-synthase	Homo sapiens	35-38
21875066-2	2011	The presence of a heme cofactor in CBS is enigmatic, and its conversion from the ferric- to ferrous-CO state inhibits enzyme activity.	Ferric enterobactin ion	81-87	cystathionine beta-synthase	Homo sapiens	35-38
21875066-2	2011	The presence of a heme cofactor in CBS is enigmatic, and its conversion from the ferric- to ferrous-CO state inhibits enzyme activity.	ammonium ferrous sulfate	92-99	cystathionine beta-synthase	Homo sapiens	35-38
21875066-4	2011	Herein, we provide the first evidence of reversible inhibition of CBS by CO in the presence of a human flavoprotein and NADPH.	NADP	120-125	cystathionine beta-synthase	Homo sapiens	66-69
21875066-5	2011	These data provide a mechanism for cross talk between two gas-signaling systems, CO and H(2)S, via heme-mediated allosteric regulation of CBS.	Hydrogen Sulfide	88-93	cystathionine beta-synthase	Homo sapiens	138-141
21875066-5	2011	These data provide a mechanism for cross talk between two gas-signaling systems, CO and H(2)S, via heme-mediated allosteric regulation of CBS.	Heme	99-103	cystathionine beta-synthase	Homo sapiens	138-141
21297080-1	2011	Hydrogen sulfide (H(2)S) is synthesized intracellularly by the enzymes cystathionine-gamma-lyase and cystathionine-beta-synthase (CBS), and is proposed to be a gasotransmitter with effects in modulating inflammation and cellular proliferation.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	101-128
21297080-1	2011	Hydrogen sulfide (H(2)S) is synthesized intracellularly by the enzymes cystathionine-gamma-lyase and cystathionine-beta-synthase (CBS), and is proposed to be a gasotransmitter with effects in modulating inflammation and cellular proliferation.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	130-133
21297080-1	2011	Hydrogen sulfide (H(2)S) is synthesized intracellularly by the enzymes cystathionine-gamma-lyase and cystathionine-beta-synthase (CBS), and is proposed to be a gasotransmitter with effects in modulating inflammation and cellular proliferation.	Hydrogen Sulfide	18-23	cystathionine beta-synthase	Homo sapiens	101-128
21297080-1	2011	Hydrogen sulfide (H(2)S) is synthesized intracellularly by the enzymes cystathionine-gamma-lyase and cystathionine-beta-synthase (CBS), and is proposed to be a gasotransmitter with effects in modulating inflammation and cellular proliferation.	Hydrogen Sulfide	18-23	cystathionine beta-synthase	Homo sapiens	130-133
21297080-9	2011	Inhibition of CBS, but not cystathionine-gamma-lyase, reversed the inhibitory effect of H(2)S on proliferation and IL-8 release, indicating that this is dependent on CBS.	Hydrogen Sulfide	88-93	cystathionine beta-synthase	Homo sapiens	14-17
21297080-9	2011	Inhibition of CBS, but not cystathionine-gamma-lyase, reversed the inhibitory effect of H(2)S on proliferation and IL-8 release, indicating that this is dependent on CBS.	Hydrogen Sulfide	88-93	cystathionine beta-synthase	Homo sapiens	166-169
21297080-10	2011	CBS mRNA and protein expression were inhibited by H(2)S donors, and were increased by methemoglobin, indicating that CBS is the main enzyme responsible for endogenous H(2)S production.	Hydrogen Sulfide	50-55	cystathionine beta-synthase	Homo sapiens	0-3
21297080-10	2011	CBS mRNA and protein expression were inhibited by H(2)S donors, and were increased by methemoglobin, indicating that CBS is the main enzyme responsible for endogenous H(2)S production.	Hydrogen Sulfide	50-55	cystathionine beta-synthase	Homo sapiens	117-120
21297080-10	2011	CBS mRNA and protein expression were inhibited by H(2)S donors, and were increased by methemoglobin, indicating that CBS is the main enzyme responsible for endogenous H(2)S production.	Hydrogen Sulfide	167-172	cystathionine beta-synthase	Homo sapiens	0-3
21297080-10	2011	CBS mRNA and protein expression were inhibited by H(2)S donors, and were increased by methemoglobin, indicating that CBS is the main enzyme responsible for endogenous H(2)S production.	Hydrogen Sulfide	167-172	cystathionine beta-synthase	Homo sapiens	117-120
21666033-3	2011	The biosynthesis of H(2)S has been attributed to three endogenous enzymes: cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CGL or CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST).	Hydrogen Sulfide	20-25	cystathionine beta-synthase	Homo sapiens	75-102
21666034-3	2011	Hydrogen sulfide can be produced in the lung and airway tissues via the actions of two H(2)S-generating enzymes, cystathionine beta-synthase (CBS) and/or cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	113-140
21703291-4	2011	Expression of homocysteine-clearing enzymes, such as cystathionine beta-synthase, methionine synthase/methylene tetrahydrofolate reductase, and betaine homocysteine methyltransferase, was up-regulated in MCF-7/Adr cells, suggesting that acquiring doxorubicin resistance attenuated methionine-dependence and activated transsulfuration from methionine to cysteine.	Homocysteine	14-26	cystathionine beta-synthase	Homo sapiens	53-80
21703291-4	2011	Expression of homocysteine-clearing enzymes, such as cystathionine beta-synthase, methionine synthase/methylene tetrahydrofolate reductase, and betaine homocysteine methyltransferase, was up-regulated in MCF-7/Adr cells, suggesting that acquiring doxorubicin resistance attenuated methionine-dependence and activated transsulfuration from methionine to cysteine.	Doxorubicin	247-258	cystathionine beta-synthase	Homo sapiens	53-80
21703291-4	2011	Expression of homocysteine-clearing enzymes, such as cystathionine beta-synthase, methionine synthase/methylene tetrahydrofolate reductase, and betaine homocysteine methyltransferase, was up-regulated in MCF-7/Adr cells, suggesting that acquiring doxorubicin resistance attenuated methionine-dependence and activated transsulfuration from methionine to cysteine.	Methionine	281-291	cystathionine beta-synthase	Homo sapiens	53-80
21703291-4	2011	Expression of homocysteine-clearing enzymes, such as cystathionine beta-synthase, methionine synthase/methylene tetrahydrofolate reductase, and betaine homocysteine methyltransferase, was up-regulated in MCF-7/Adr cells, suggesting that acquiring doxorubicin resistance attenuated methionine-dependence and activated transsulfuration from methionine to cysteine.	Cysteine	18-26	cystathionine beta-synthase	Homo sapiens	53-80
21558438-9	2011	Infusion of hydroxylamine (30 mM, 50 nl), a cystathionine beta-synthase inhibitor, increased ABP, HR, and RSNA.	Hydroxylamine	12-25	cystathionine beta-synthase	Homo sapiens	44-71
21417705-1	2011	OBJECT: Cystathionine beta-synthase (CBS) is an enzyme that metabolizes homocysteine to form H(2)S in the brain.	Homocysteine	72-84	cystathionine beta-synthase	Homo sapiens	8-35
21417705-1	2011	OBJECT: Cystathionine beta-synthase (CBS) is an enzyme that metabolizes homocysteine to form H(2)S in the brain.	Homocysteine	72-84	cystathionine beta-synthase	Homo sapiens	37-40
21417705-1	2011	OBJECT: Cystathionine beta-synthase (CBS) is an enzyme that metabolizes homocysteine to form H(2)S in the brain.	Hydrogen Sulfide	93-98	cystathionine beta-synthase	Homo sapiens	8-35
21417705-1	2011	OBJECT: Cystathionine beta-synthase (CBS) is an enzyme that metabolizes homocysteine to form H(2)S in the brain.	Hydrogen Sulfide	93-98	cystathionine beta-synthase	Homo sapiens	37-40
21417705-3	2011	Given the myriad effects of H(2)S, the authors hypothesized that patients possessing gain-of-function polymorphisms of the CBS gene will experience a decreased incidence of delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH).	Hydrogen Sulfide	28-33	cystathionine beta-synthase	Homo sapiens	123-126
21417705-3	2011	Given the myriad effects of H(2)S, the authors hypothesized that patients possessing gain-of-function polymorphisms of the CBS gene will experience a decreased incidence of delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH).	dci	200-203	cystathionine beta-synthase	Homo sapiens	123-126
21417705-7	2011	Multivariate analysis was used to determine the relationship between CBS genotype and occurrence of both angiographic vasospasm and DCI.	dci	132-135	cystathionine beta-synthase	Homo sapiens	69-72
21417705-12	2011	CONCLUSIONS: Polymorphisms of the CBS gene that impart gain-of-function may be associated with a reduced risk of DCI after aSAH, independent of serum homocysteine.	Homocysteine	150-162	cystathionine beta-synthase	Homo sapiens	34-37
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Iron	106-108	cystathionine beta-synthase	Homo sapiens	175-179
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Cysteine	115-118	cystathionine beta-synthase	Homo sapiens	26-29
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Cysteine	115-118	cystathionine beta-synthase	Homo sapiens	109-113
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Cysteine	115-118	cystathionine beta-synthase	Homo sapiens	175-179
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Histidine	119-122	cystathionine beta-synthase	Homo sapiens	26-29
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Histidine	119-122	cystathionine beta-synthase	Homo sapiens	109-113
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Histidine	119-122	cystathionine beta-synthase	Homo sapiens	175-179
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Cobalt	172-174	cystathionine beta-synthase	Homo sapiens	26-29
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Cobalt	172-174	cystathionine beta-synthase	Homo sapiens	109-113
21480614-10	2011	Canonical and alternative CBS assays suggest that maintaining the native heme ligation motif of wild-type Fe hCBS (Cys/His) is essential in maintaining maximal activity in Co hCBS.	Cobalt	172-174	cystathionine beta-synthase	Homo sapiens	175-179
21480614-11	2011	Correlation between the coordination structures and enzyme activity in both native Fe and Co-substituted proteins implicates a structural role for the heme in CBS.	Heme	151-155	cystathionine beta-synthase	Homo sapiens	159-162
21480614-1	2011	Human cystathionine beta-synthase (hCBS), a key enzyme in the trans-sulfuration pathway, catalyzes the condensation of serine with homocysteine to produce cystathionine.	Serine	119-125	cystathionine beta-synthase	Homo sapiens	6-33
21480614-1	2011	Human cystathionine beta-synthase (hCBS), a key enzyme in the trans-sulfuration pathway, catalyzes the condensation of serine with homocysteine to produce cystathionine.	Serine	119-125	cystathionine beta-synthase	Homo sapiens	35-39
21480614-1	2011	Human cystathionine beta-synthase (hCBS), a key enzyme in the trans-sulfuration pathway, catalyzes the condensation of serine with homocysteine to produce cystathionine.	Homocysteine	131-143	cystathionine beta-synthase	Homo sapiens	6-33
21480614-1	2011	Human cystathionine beta-synthase (hCBS), a key enzyme in the trans-sulfuration pathway, catalyzes the condensation of serine with homocysteine to produce cystathionine.	Homocysteine	131-143	cystathionine beta-synthase	Homo sapiens	35-39
21480614-1	2011	Human cystathionine beta-synthase (hCBS), a key enzyme in the trans-sulfuration pathway, catalyzes the condensation of serine with homocysteine to produce cystathionine.	Cystathionine	6-19	cystathionine beta-synthase	Homo sapiens	35-39
21480614-2	2011	CBS from higher organisms is the only known protein that binds pyridoxal-5"-phosphate (PLP) and heme.	Pyridoxal Phosphate	63-85	cystathionine beta-synthase	Homo sapiens	0-3
21480614-2	2011	CBS from higher organisms is the only known protein that binds pyridoxal-5"-phosphate (PLP) and heme.	Pyridoxal Phosphate	87-90	cystathionine beta-synthase	Homo sapiens	0-3
21480614-2	2011	CBS from higher organisms is the only known protein that binds pyridoxal-5"-phosphate (PLP) and heme.	Heme	96-100	cystathionine beta-synthase	Homo sapiens	0-3
21480614-3	2011	Intriguingly, the function of the heme in hCBS has yet to be elucidated.	Heme	34-38	cystathionine beta-synthase	Homo sapiens	42-46
21480614-4	2011	Herein, we describe the characterization of a cobalt-substituted variant of hCBS (Co hCBS) in which CoPPIX replaces FePPIX (heme).	Cobalt	46-52	cystathionine beta-synthase	Homo sapiens	76-80
21480614-4	2011	Herein, we describe the characterization of a cobalt-substituted variant of hCBS (Co hCBS) in which CoPPIX replaces FePPIX (heme).	Cobalt	46-52	cystathionine beta-synthase	Homo sapiens	85-89
21480614-4	2011	Herein, we describe the characterization of a cobalt-substituted variant of hCBS (Co hCBS) in which CoPPIX replaces FePPIX (heme).	Cobalt	82-84	cystathionine beta-synthase	Homo sapiens	76-80
21480614-4	2011	Herein, we describe the characterization of a cobalt-substituted variant of hCBS (Co hCBS) in which CoPPIX replaces FePPIX (heme).	Cobalt	82-84	cystathionine beta-synthase	Homo sapiens	85-89
21480614-4	2011	Herein, we describe the characterization of a cobalt-substituted variant of hCBS (Co hCBS) in which CoPPIX replaces FePPIX (heme).	coppix	100-106	cystathionine beta-synthase	Homo sapiens	76-80
21480614-4	2011	Herein, we describe the characterization of a cobalt-substituted variant of hCBS (Co hCBS) in which CoPPIX replaces FePPIX (heme).	coppix	100-106	cystathionine beta-synthase	Homo sapiens	85-89
21480614-4	2011	Herein, we describe the characterization of a cobalt-substituted variant of hCBS (Co hCBS) in which CoPPIX replaces FePPIX (heme).	Heme	116-122	cystathionine beta-synthase	Homo sapiens	76-80
21480614-4	2011	Herein, we describe the characterization of a cobalt-substituted variant of hCBS (Co hCBS) in which CoPPIX replaces FePPIX (heme).	Heme	116-122	cystathionine beta-synthase	Homo sapiens	85-89
21480614-4	2011	Herein, we describe the characterization of a cobalt-substituted variant of hCBS (Co hCBS) in which CoPPIX replaces FePPIX (heme).	Heme	124-128	cystathionine beta-synthase	Homo sapiens	76-80
21480614-4	2011	Herein, we describe the characterization of a cobalt-substituted variant of hCBS (Co hCBS) in which CoPPIX replaces FePPIX (heme).	Heme	124-128	cystathionine beta-synthase	Homo sapiens	85-89
21480614-5	2011	Co(III) hCBS is a unique Co-substituted heme protein: the Co(III) ion is 6-coordinate, low-spin, diamagnetic, and bears a cysteine(thiolate) as one of its axial ligands.	Cysteine	122-130	cystathionine beta-synthase	Homo sapiens	8-12
21480614-5	2011	Co(III) hCBS is a unique Co-substituted heme protein: the Co(III) ion is 6-coordinate, low-spin, diamagnetic, and bears a cysteine(thiolate) as one of its axial ligands.	thiolate	131-139	cystathionine beta-synthase	Homo sapiens	8-12
21480614-6	2011	The peak positions and intensities of the electronic absorption and MCD spectra of Co(III) hCBS are distinct from those of previously Co-substituted heme proteins; TD-DFT calculations reveal that the unique features arise from the 6-coordinate Co bound axially by cysteine(thiolate) and a neutral donor, presumably histidine.	Heme	149-153	cystathionine beta-synthase	Homo sapiens	91-95
21480614-6	2011	The peak positions and intensities of the electronic absorption and MCD spectra of Co(III) hCBS are distinct from those of previously Co-substituted heme proteins; TD-DFT calculations reveal that the unique features arise from the 6-coordinate Co bound axially by cysteine(thiolate) and a neutral donor, presumably histidine.	Cysteine	264-272	cystathionine beta-synthase	Homo sapiens	91-95
21480614-6	2011	The peak positions and intensities of the electronic absorption and MCD spectra of Co(III) hCBS are distinct from those of previously Co-substituted heme proteins; TD-DFT calculations reveal that the unique features arise from the 6-coordinate Co bound axially by cysteine(thiolate) and a neutral donor, presumably histidine.	thiolate	273-281	cystathionine beta-synthase	Homo sapiens	91-95
21480614-6	2011	The peak positions and intensities of the electronic absorption and MCD spectra of Co(III) hCBS are distinct from those of previously Co-substituted heme proteins; TD-DFT calculations reveal that the unique features arise from the 6-coordinate Co bound axially by cysteine(thiolate) and a neutral donor, presumably histidine.	Histidine	315-324	cystathionine beta-synthase	Homo sapiens	91-95
21480614-7	2011	Reactivity of Co(III) hCBS with HgCl(2) is consistent with a loss of the cysteine(thiolate) ligand.	Mercuric Chloride	32-39	cystathionine beta-synthase	Homo sapiens	22-26
21480614-7	2011	Reactivity of Co(III) hCBS with HgCl(2) is consistent with a loss of the cysteine(thiolate) ligand.	Cysteine	73-81	cystathionine beta-synthase	Homo sapiens	22-26
21480614-7	2011	Reactivity of Co(III) hCBS with HgCl(2) is consistent with a loss of the cysteine(thiolate) ligand.	thiolate	82-90	cystathionine beta-synthase	Homo sapiens	22-26
21480614-8	2011	Co(III) hCBS is slowly reduced to Co(II) hCBS, which contains a 5-coordinate, low-spin, S = 1/2 Co-porphyrin that does not retain the cysteine(thiolate) ligand; this form of Co(II) hCBS binds NO((g)) but not CO((g)).	co-porphyrin	96-108	cystathionine beta-synthase	Homo sapiens	8-12
21480614-8	2011	Co(III) hCBS is slowly reduced to Co(II) hCBS, which contains a 5-coordinate, low-spin, S = 1/2 Co-porphyrin that does not retain the cysteine(thiolate) ligand; this form of Co(II) hCBS binds NO((g)) but not CO((g)).	co-porphyrin	96-108	cystathionine beta-synthase	Homo sapiens	41-45
21480614-8	2011	Co(III) hCBS is slowly reduced to Co(II) hCBS, which contains a 5-coordinate, low-spin, S = 1/2 Co-porphyrin that does not retain the cysteine(thiolate) ligand; this form of Co(II) hCBS binds NO((g)) but not CO((g)).	co-porphyrin	96-108	cystathionine beta-synthase	Homo sapiens	41-45
21467968-2	2011	H(2)S is formed endogenously from L-cysteine or L-methionine by two enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), and normally circulates in blood.	Hydrogen Sulfide	0-5	cystathionine beta-synthase	Homo sapiens	77-104
21467968-2	2011	H(2)S is formed endogenously from L-cysteine or L-methionine by two enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), and normally circulates in blood.	Methionine	48-60	cystathionine beta-synthase	Homo sapiens	77-104
21467968-2	2011	H(2)S is formed endogenously from L-cysteine or L-methionine by two enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), and normally circulates in blood.	Hydrogen Sulfide	0-5	cystathionine beta-synthase	Homo sapiens	106-109
21467968-2	2011	H(2)S is formed endogenously from L-cysteine or L-methionine by two enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), and normally circulates in blood.	Methionine	48-60	cystathionine beta-synthase	Homo sapiens	106-109
21467968-6	2011	In humans, both CBS and CSE are widely expressed on trabecular muscle, implying that the smooth muscle component is the major source of H(2)S.	Hydrogen Sulfide	136-141	cystathionine beta-synthase	Homo sapiens	16-19
21467968-2	2011	H(2)S is formed endogenously from L-cysteine or L-methionine by two enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), and normally circulates in blood.	Cysteine	34-44	cystathionine beta-synthase	Homo sapiens	77-104
21467968-2	2011	H(2)S is formed endogenously from L-cysteine or L-methionine by two enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), and normally circulates in blood.	Cysteine	34-44	cystathionine beta-synthase	Homo sapiens	106-109
21262193-0	2011	Purification and characterization of cystathionine beta-synthase bearing a cobalt protoporphyrin.	cobaltiprotoporphyrin	75-96	cystathionine beta-synthase	Homo sapiens	37-64
21262193-1	2011	Human cystathionine beta-synthase (CBS), a pivotal enzyme in the metabolism of homocysteine, is a pyridoxal-5"-phosphate-dependent enzyme that also contains heme, a second cofactor whose function is still unclear.	Pyridoxal Phosphate	98-120	cystathionine beta-synthase	Homo sapiens	6-33
21262193-1	2011	Human cystathionine beta-synthase (CBS), a pivotal enzyme in the metabolism of homocysteine, is a pyridoxal-5"-phosphate-dependent enzyme that also contains heme, a second cofactor whose function is still unclear.	Homocysteine	79-91	cystathionine beta-synthase	Homo sapiens	6-33
21262193-1	2011	Human cystathionine beta-synthase (CBS), a pivotal enzyme in the metabolism of homocysteine, is a pyridoxal-5"-phosphate-dependent enzyme that also contains heme, a second cofactor whose function is still unclear.	Pyridoxal Phosphate	98-120	cystathionine beta-synthase	Homo sapiens	35-38
21262193-1	2011	Human cystathionine beta-synthase (CBS), a pivotal enzyme in the metabolism of homocysteine, is a pyridoxal-5"-phosphate-dependent enzyme that also contains heme, a second cofactor whose function is still unclear.	Heme	157-161	cystathionine beta-synthase	Homo sapiens	6-33
21262193-1	2011	Human cystathionine beta-synthase (CBS), a pivotal enzyme in the metabolism of homocysteine, is a pyridoxal-5"-phosphate-dependent enzyme that also contains heme, a second cofactor whose function is still unclear.	Homocysteine	79-91	cystathionine beta-synthase	Homo sapiens	35-38
21262193-1	2011	Human cystathionine beta-synthase (CBS), a pivotal enzyme in the metabolism of homocysteine, is a pyridoxal-5"-phosphate-dependent enzyme that also contains heme, a second cofactor whose function is still unclear.	Heme	157-161	cystathionine beta-synthase	Homo sapiens	35-38
21275900-2	2011	CBS catalyzes the pyridoxal 5"-phosphate (PLP)-dependent conversion of homocysteine in Cystathionine whilst CSE the pyridoxal 5"-phosphate (PLP)-dependent synthesis of L-cysteine from Cystathionine.	Pyridoxal Phosphate	18-40	cystathionine beta-synthase	Homo sapiens	0-3
21184140-2	2011	Here we present another aspect of increased cobalt concentrations in the culture medium resulting in the production of cobalt protoporphyrin IX (CoPPIX), which was incorporated into heme proteins including membrane-bound cytochromes and an expressed human cystathionine beta-synthase (CBS).	Cobalt	44-50	cystathionine beta-synthase	Homo sapiens	256-283
21184140-2	2011	Here we present another aspect of increased cobalt concentrations in the culture medium resulting in the production of cobalt protoporphyrin IX (CoPPIX), which was incorporated into heme proteins including membrane-bound cytochromes and an expressed human cystathionine beta-synthase (CBS).	cobaltiprotoporphyrin	119-143	cystathionine beta-synthase	Homo sapiens	256-283
21184140-2	2011	Here we present another aspect of increased cobalt concentrations in the culture medium resulting in the production of cobalt protoporphyrin IX (CoPPIX), which was incorporated into heme proteins including membrane-bound cytochromes and an expressed human cystathionine beta-synthase (CBS).	cobaltiprotoporphyrin	145-151	cystathionine beta-synthase	Homo sapiens	256-283
21275894-2	2011	H(2)S is generated by three enzymes, cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST).	Hydrogen Sulfide	0-5	cystathionine beta-synthase	Homo sapiens	37-64
21275900-2	2011	CBS catalyzes the pyridoxal 5"-phosphate (PLP)-dependent conversion of homocysteine in Cystathionine whilst CSE the pyridoxal 5"-phosphate (PLP)-dependent synthesis of L-cysteine from Cystathionine.	Pyridoxal Phosphate	42-45	cystathionine beta-synthase	Homo sapiens	0-3
21275894-2	2011	H(2)S is generated by three enzymes, cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST).	Hydrogen Sulfide	0-5	cystathionine beta-synthase	Homo sapiens	66-69
21275900-2	2011	CBS catalyzes the pyridoxal 5"-phosphate (PLP)-dependent conversion of homocysteine in Cystathionine whilst CSE the pyridoxal 5"-phosphate (PLP)-dependent synthesis of L-cysteine from Cystathionine.	Homocysteine	71-83	cystathionine beta-synthase	Homo sapiens	0-3
21275894-3	2011	In the CNS, H(2)S, generated mainly by CBS in astrocytes and 3MST in neurons, appears to participate in cognition, memory, regulation of the cardiopulmonary functions and neuroprotection.	Hydrogen Sulfide	12-17	cystathionine beta-synthase	Homo sapiens	39-42
21275895-3	2011	The production of H(2)S from L-cysteine is catalysed primarily by two enzymes, cystathionine gamma-lyase and cystathionine beta-synthase.	Hydrogen Sulfide	18-23	cystathionine beta-synthase	Homo sapiens	109-136
21275900-2	2011	CBS catalyzes the pyridoxal 5"-phosphate (PLP)-dependent conversion of homocysteine in Cystathionine whilst CSE the pyridoxal 5"-phosphate (PLP)-dependent synthesis of L-cysteine from Cystathionine.	Cystathionine	87-100	cystathionine beta-synthase	Homo sapiens	0-3
21275895-3	2011	The production of H(2)S from L-cysteine is catalysed primarily by two enzymes, cystathionine gamma-lyase and cystathionine beta-synthase.	Cysteine	29-39	cystathionine beta-synthase	Homo sapiens	109-136
21275900-2	2011	CBS catalyzes the pyridoxal 5"-phosphate (PLP)-dependent conversion of homocysteine in Cystathionine whilst CSE the pyridoxal 5"-phosphate (PLP)-dependent synthesis of L-cysteine from Cystathionine.	Pyridoxal Phosphate	116-138	cystathionine beta-synthase	Homo sapiens	0-3
21275897-1	2011	Hydrogen sulfide (H(2)S) is a gas that can be formed by the action of two enzymes, cystathionine gamma lyase (CSE) and cystathionine beta synthase (CBS).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	119-146
21275897-1	2011	Hydrogen sulfide (H(2)S) is a gas that can be formed by the action of two enzymes, cystathionine gamma lyase (CSE) and cystathionine beta synthase (CBS).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	148-151
21275900-2	2011	CBS catalyzes the pyridoxal 5"-phosphate (PLP)-dependent conversion of homocysteine in Cystathionine whilst CSE the pyridoxal 5"-phosphate (PLP)-dependent synthesis of L-cysteine from Cystathionine.	Pyridoxal Phosphate	140-143	cystathionine beta-synthase	Homo sapiens	0-3
21275897-1	2011	Hydrogen sulfide (H(2)S) is a gas that can be formed by the action of two enzymes, cystathionine gamma lyase (CSE) and cystathionine beta synthase (CBS).	Hydrogen Sulfide	18-23	cystathionine beta-synthase	Homo sapiens	119-146
21275900-2	2011	CBS catalyzes the pyridoxal 5"-phosphate (PLP)-dependent conversion of homocysteine in Cystathionine whilst CSE the pyridoxal 5"-phosphate (PLP)-dependent synthesis of L-cysteine from Cystathionine.	Cysteine	168-178	cystathionine beta-synthase	Homo sapiens	0-3
21275897-1	2011	Hydrogen sulfide (H(2)S) is a gas that can be formed by the action of two enzymes, cystathionine gamma lyase (CSE) and cystathionine beta synthase (CBS).	Hydrogen Sulfide	18-23	cystathionine beta-synthase	Homo sapiens	148-151
21275900-0	2011	Hydrogen sulfide generation in mammals: the molecular biology of cystathionine-beta- synthase (CBS) and cystathionine-gamma-lyase (CSE).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	65-93
21275900-2	2011	CBS catalyzes the pyridoxal 5"-phosphate (PLP)-dependent conversion of homocysteine in Cystathionine whilst CSE the pyridoxal 5"-phosphate (PLP)-dependent synthesis of L-cysteine from Cystathionine.	Cystathionine	184-197	cystathionine beta-synthase	Homo sapiens	0-3
21275900-0	2011	Hydrogen sulfide generation in mammals: the molecular biology of cystathionine-beta- synthase (CBS) and cystathionine-gamma-lyase (CSE).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	95-98
21275900-4	2011	In fact, the CBS enzyme contains a heme cofactor that functions as a redox sensor and utilizes S-adenosylmethionine (SAM) as an allosteric activator.	Heme	35-39	cystathionine beta-synthase	Homo sapiens	13-16
21275900-1	2011	Cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) are two key enzymes involved in the synthesis of hydrogen sulphide (H(2)S).	Hydrogen Sulfide	119-136	cystathionine beta-synthase	Homo sapiens	0-27
21275900-1	2011	Cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) are two key enzymes involved in the synthesis of hydrogen sulphide (H(2)S).	Hydrogen Sulfide	119-136	cystathionine beta-synthase	Homo sapiens	29-32
21275900-4	2011	In fact, the CBS enzyme contains a heme cofactor that functions as a redox sensor and utilizes S-adenosylmethionine (SAM) as an allosteric activator.	S-Adenosylmethionine	95-115	cystathionine beta-synthase	Homo sapiens	13-16
21275900-9	2011	This review focuses on the recent aspects of the molecular regulation of both CBS and CSE and highlights the possibility that members of the nuclear receptors superfamily might be involved in the regulation of hydrogen sulphide metabolism.	Hydrogen Sulfide	210-227	cystathionine beta-synthase	Homo sapiens	78-81
21444658-2	2011	Such modulation is thought to be mediated by direct binding of ATP to the cystathionine beta-synthase (CBS) domains at the C-terminal cytoplasmic region of CLC-1.	Adenosine Triphosphate	63-66	cystathionine beta-synthase	Homo sapiens	74-101
21141970-1	2011	Cystathionine beta-synthase (CBS) catalyzes the first step in the transsulfuration pathway in mammals, i.e., the condensation of serine and homocysteine to produce cystathionine and water.	Water	182-187	cystathionine beta-synthase	Homo sapiens	29-32
21195095-3	2011	Our data showed that the cadmium ions with a sub-lethal concentration could induce RAR in Chang liver cells towards subsequent gamma-irradiation and this response could be abrogated by DL-propargylglycine (PPG), the endogenous H(2)S synthetase inhibitor of cystathionine gamma-lyase (CSE), but not by aminooxyacetic acid (AOAA), the inhibitor of cystathionine beta-synthase (CBS).	Cadmium	25-32	cystathionine beta-synthase	Homo sapiens	346-373
21195095-3	2011	Our data showed that the cadmium ions with a sub-lethal concentration could induce RAR in Chang liver cells towards subsequent gamma-irradiation and this response could be abrogated by DL-propargylglycine (PPG), the endogenous H(2)S synthetase inhibitor of cystathionine gamma-lyase (CSE), but not by aminooxyacetic acid (AOAA), the inhibitor of cystathionine beta-synthase (CBS).	Cadmium	25-32	cystathionine beta-synthase	Homo sapiens	375-378
20821054-3	2011	We developed an assay to measure CBS activity in 20 muL of plasma using a stable isotope substrate - 2,3,3-(2)H serine.	2,3,3-(2)h	101-111	cystathionine beta-synthase	Homo sapiens	33-36
20821054-3	2011	We developed an assay to measure CBS activity in 20 muL of plasma using a stable isotope substrate - 2,3,3-(2)H serine.	Serine	112-118	cystathionine beta-synthase	Homo sapiens	33-36
20821054-7	2011	The presence of CBS in human plasma was confirmed by an in silico search of the proteome database, and was further evidenced by the activation of CBS by S-adenosyl-L-methionine and pyridoxal 5"-phosphate, and by configuration of the detected reaction product, 3,3-(2)H-cystathionine, which was in agreement with the previously observed CBS reaction mechanism.	S-Adenosylmethionine	153-176	cystathionine beta-synthase	Homo sapiens	16-19
20821054-7	2011	The presence of CBS in human plasma was confirmed by an in silico search of the proteome database, and was further evidenced by the activation of CBS by S-adenosyl-L-methionine and pyridoxal 5"-phosphate, and by configuration of the detected reaction product, 3,3-(2)H-cystathionine, which was in agreement with the previously observed CBS reaction mechanism.	S-Adenosylmethionine	153-176	cystathionine beta-synthase	Homo sapiens	146-149
20821054-7	2011	The presence of CBS in human plasma was confirmed by an in silico search of the proteome database, and was further evidenced by the activation of CBS by S-adenosyl-L-methionine and pyridoxal 5"-phosphate, and by configuration of the detected reaction product, 3,3-(2)H-cystathionine, which was in agreement with the previously observed CBS reaction mechanism.	S-Adenosylmethionine	153-176	cystathionine beta-synthase	Homo sapiens	146-149
20821054-7	2011	The presence of CBS in human plasma was confirmed by an in silico search of the proteome database, and was further evidenced by the activation of CBS by S-adenosyl-L-methionine and pyridoxal 5"-phosphate, and by configuration of the detected reaction product, 3,3-(2)H-cystathionine, which was in agreement with the previously observed CBS reaction mechanism.	Pyridoxal Phosphate	181-203	cystathionine beta-synthase	Homo sapiens	16-19
20821054-7	2011	The presence of CBS in human plasma was confirmed by an in silico search of the proteome database, and was further evidenced by the activation of CBS by S-adenosyl-L-methionine and pyridoxal 5"-phosphate, and by configuration of the detected reaction product, 3,3-(2)H-cystathionine, which was in agreement with the previously observed CBS reaction mechanism.	Pyridoxal Phosphate	181-203	cystathionine beta-synthase	Homo sapiens	146-149
20821054-7	2011	The presence of CBS in human plasma was confirmed by an in silico search of the proteome database, and was further evidenced by the activation of CBS by S-adenosyl-L-methionine and pyridoxal 5"-phosphate, and by configuration of the detected reaction product, 3,3-(2)H-cystathionine, which was in agreement with the previously observed CBS reaction mechanism.	Pyridoxal Phosphate	181-203	cystathionine beta-synthase	Homo sapiens	146-149
20821054-7	2011	The presence of CBS in human plasma was confirmed by an in silico search of the proteome database, and was further evidenced by the activation of CBS by S-adenosyl-L-methionine and pyridoxal 5"-phosphate, and by configuration of the detected reaction product, 3,3-(2)H-cystathionine, which was in agreement with the previously observed CBS reaction mechanism.	3,3-(2)h-cystathionine	260-282	cystathionine beta-synthase	Homo sapiens	16-19
20821054-7	2011	The presence of CBS in human plasma was confirmed by an in silico search of the proteome database, and was further evidenced by the activation of CBS by S-adenosyl-L-methionine and pyridoxal 5"-phosphate, and by configuration of the detected reaction product, 3,3-(2)H-cystathionine, which was in agreement with the previously observed CBS reaction mechanism.	3,3-(2)h-cystathionine	260-282	cystathionine beta-synthase	Homo sapiens	146-149
20821054-7	2011	The presence of CBS in human plasma was confirmed by an in silico search of the proteome database, and was further evidenced by the activation of CBS by S-adenosyl-L-methionine and pyridoxal 5"-phosphate, and by configuration of the detected reaction product, 3,3-(2)H-cystathionine, which was in agreement with the previously observed CBS reaction mechanism.	3,3-(2)h-cystathionine	260-282	cystathionine beta-synthase	Homo sapiens	146-149
20821054-10	2011	CBS assay in human plasma brings new possibilities in the diagnosis of pyridoxine nonresponsive CBS deficiency.	Pyridoxine	71-81	cystathionine beta-synthase	Homo sapiens	0-3
21141970-1	2011	Cystathionine beta-synthase (CBS) catalyzes the first step in the transsulfuration pathway in mammals, i.e., the condensation of serine and homocysteine to produce cystathionine and water.	Serine	129-135	cystathionine beta-synthase	Homo sapiens	0-27
21141970-1	2011	Cystathionine beta-synthase (CBS) catalyzes the first step in the transsulfuration pathway in mammals, i.e., the condensation of serine and homocysteine to produce cystathionine and water.	Serine	129-135	cystathionine beta-synthase	Homo sapiens	29-32
21141970-1	2011	Cystathionine beta-synthase (CBS) catalyzes the first step in the transsulfuration pathway in mammals, i.e., the condensation of serine and homocysteine to produce cystathionine and water.	Homocysteine	140-152	cystathionine beta-synthase	Homo sapiens	0-27
21141970-1	2011	Cystathionine beta-synthase (CBS) catalyzes the first step in the transsulfuration pathway in mammals, i.e., the condensation of serine and homocysteine to produce cystathionine and water.	Homocysteine	140-152	cystathionine beta-synthase	Homo sapiens	29-32
21141970-2	2011	Recently, we have reported a steady-state kinetic analysis of the three hydrogen sulfide (H(2)S)-generating reactions that are catalyzed by human and yeast CBS [Singh, S., et al.	Hydrogen Sulfide	72-88	cystathionine beta-synthase	Homo sapiens	156-159
21141970-1	2011	Cystathionine beta-synthase (CBS) catalyzes the first step in the transsulfuration pathway in mammals, i.e., the condensation of serine and homocysteine to produce cystathionine and water.	Cystathionine	164-177	cystathionine beta-synthase	Homo sapiens	0-27
21141970-1	2011	Cystathionine beta-synthase (CBS) catalyzes the first step in the transsulfuration pathway in mammals, i.e., the condensation of serine and homocysteine to produce cystathionine and water.	Cystathionine	164-177	cystathionine beta-synthase	Homo sapiens	29-32
21141970-1	2011	Cystathionine beta-synthase (CBS) catalyzes the first step in the transsulfuration pathway in mammals, i.e., the condensation of serine and homocysteine to produce cystathionine and water.	Water	182-187	cystathionine beta-synthase	Homo sapiens	0-27
21141970-2	2011	Recently, we have reported a steady-state kinetic analysis of the three hydrogen sulfide (H(2)S)-generating reactions that are catalyzed by human and yeast CBS [Singh, S., et al.	Hydrogen Sulfide	90-95	cystathionine beta-synthase	Homo sapiens	156-159
21141970-7	2011	Because yCBS does not have a heme cofactor, in contrast to human CBS, it is easier to observe reaction intermediates with yCBS.	ycbs	122-126	cystathionine beta-synthase	Homo sapiens	9-12
21228576-6	2011	Cystathionine gamma-lyase, cystathionine beta-synthase, and 3-mercaptopyruvate sulfurtransferase are the principal enzymes involved in H(2)S production.	Hydrogen Sulfide	135-140	cystathionine beta-synthase	Homo sapiens	27-54
20971760-0	2011	Vascular complications of cystathionine beta-synthase deficiency: future directions for homocysteine-to-hydrogen sulfide research.	Homocysteine	88-100	cystathionine beta-synthase	Homo sapiens	26-53
20971760-0	2011	Vascular complications of cystathionine beta-synthase deficiency: future directions for homocysteine-to-hydrogen sulfide research.	Hydrogen Sulfide	104-120	cystathionine beta-synthase	Homo sapiens	26-53
20971760-4	2011	Mutations in the CBS gene decrease enzymatic activity, which increases the plasma Hcy concentration, a condition called hyperhomocysteinemia (HHcy).	Homocysteine	82-85	cystathionine beta-synthase	Homo sapiens	17-20
21297920-0	2011	Carbon monoxide stimulates global protein methylation via its inhibitory action on cystathionine beta-synthase.	Carbon Monoxide	0-15	cystathionine beta-synthase	Homo sapiens	83-110
22115351-6	2011	H(2)S levels may be induced by the administration of H(2)S or H(2)S donors, or alternatively be reduced by the administration of specific cystathionine beta-synthase or cystathionine gamma-lyase inhibitors.	Hydrogen Sulfide	0-5	cystathionine beta-synthase	Homo sapiens	138-165
22115353-8	2011	As cystathionine beta-synthase and cystathionine gamma-lyase are the enzymes that are able to catalyze the production of endogenous hydrogen sulfide from cysteine, their inhibitors, such as dl-propylargylglycine and beta-cyanoalanine, have been frequently used in studies on the biological mechanism of hydrogen sulfide.	Hydrogen Sulfide	132-148	cystathionine beta-synthase	Homo sapiens	3-30
22115353-8	2011	As cystathionine beta-synthase and cystathionine gamma-lyase are the enzymes that are able to catalyze the production of endogenous hydrogen sulfide from cysteine, their inhibitors, such as dl-propylargylglycine and beta-cyanoalanine, have been frequently used in studies on the biological mechanism of hydrogen sulfide.	Cysteine	154-162	cystathionine beta-synthase	Homo sapiens	3-30
22115353-8	2011	As cystathionine beta-synthase and cystathionine gamma-lyase are the enzymes that are able to catalyze the production of endogenous hydrogen sulfide from cysteine, their inhibitors, such as dl-propylargylglycine and beta-cyanoalanine, have been frequently used in studies on the biological mechanism of hydrogen sulfide.	dl-propylargylglycine	190-211	cystathionine beta-synthase	Homo sapiens	3-30
22115353-8	2011	As cystathionine beta-synthase and cystathionine gamma-lyase are the enzymes that are able to catalyze the production of endogenous hydrogen sulfide from cysteine, their inhibitors, such as dl-propylargylglycine and beta-cyanoalanine, have been frequently used in studies on the biological mechanism of hydrogen sulfide.	3-cyanoalanine	216-233	cystathionine beta-synthase	Homo sapiens	3-30
22115353-8	2011	As cystathionine beta-synthase and cystathionine gamma-lyase are the enzymes that are able to catalyze the production of endogenous hydrogen sulfide from cysteine, their inhibitors, such as dl-propylargylglycine and beta-cyanoalanine, have been frequently used in studies on the biological mechanism of hydrogen sulfide.	Hydrogen Sulfide	303-319	cystathionine beta-synthase	Homo sapiens	3-30
21297920-2	2011	Based on our previous results in vivo suggesting carbon monoxide serves as an inhibitor of cystathionine beta-synthase that rate-limits transsulfuration pathway for generation of hydrogen sulfide, we have herein hypothesized that the gas might serve as a regulator of protein methylation through accelerating turnover of remethylation cycle residing at the upstream of the enzyme.	Carbon Monoxide	49-64	cystathionine beta-synthase	Homo sapiens	91-118
21297920-2	2011	Based on our previous results in vivo suggesting carbon monoxide serves as an inhibitor of cystathionine beta-synthase that rate-limits transsulfuration pathway for generation of hydrogen sulfide, we have herein hypothesized that the gas might serve as a regulator of protein methylation through accelerating turnover of remethylation cycle residing at the upstream of the enzyme.	Hydrogen Sulfide	179-195	cystathionine beta-synthase	Homo sapiens	91-118
21297920-3	2011	Metabolomic analysis in human monoblastic leukemia U937 cells in culture revealed that application of carbon monoxide-releasing molecules caused increases in methionine and S-adenosylmethionine and a decrease in cystathionine in the cells, suggesting the cystathionine beta-synthase inhibition by carbon monoxide.	Carbon Monoxide	102-117	cystathionine beta-synthase	Homo sapiens	255-282
21297920-5	2011	The protein arginine methylation elicited by carbon monoxide was attenuated by knocking down cystathionine beta-synthase with its small interfering RNA or by blocking S-adenosylhomocysteine hydrolase with adenosine dialdehyde, suggesting remethylation cycling is necessary to trigger the methylation processing.	Arginine	12-20	cystathionine beta-synthase	Homo sapiens	93-120
21297920-5	2011	The protein arginine methylation elicited by carbon monoxide was attenuated by knocking down cystathionine beta-synthase with its small interfering RNA or by blocking S-adenosylhomocysteine hydrolase with adenosine dialdehyde, suggesting remethylation cycling is necessary to trigger the methylation processing.	Carbon Monoxide	45-60	cystathionine beta-synthase	Homo sapiens	93-120
21297920-7	2011	Collectively with our studies in vivo showing its inhibitory action on endogenous hydrogen sulfide production, the current results suggest that not only inhibition of transsulfuration pathway for H(2)S generation but also activation of protein methylation accounts for notable biological actions of carbon monoxide via the cystathionine beta-synthase inhibition.	Hydrogen Sulfide	82-98	cystathionine beta-synthase	Homo sapiens	323-350
21297920-7	2011	Collectively with our studies in vivo showing its inhibitory action on endogenous hydrogen sulfide production, the current results suggest that not only inhibition of transsulfuration pathway for H(2)S generation but also activation of protein methylation accounts for notable biological actions of carbon monoxide via the cystathionine beta-synthase inhibition.	Carbon Monoxide	299-314	cystathionine beta-synthase	Homo sapiens	323-350
21886822-9	2011	These effects of L-cysteine were blocked by the inhibitors of CBS and CSE.	Cysteine	17-27	cystathionine beta-synthase	Homo sapiens	62-65
21952317-4	2011	Under this hypoxic condition, when the cells were treated with DL-propargylglycine (PPG) and aminooxyacetic acid (AOAA), a specific inhibitor of H(2)S synthase of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) respectively, radiation responses including cell killing, micronuclei (MN) formation, and caspase-3 activity were significantly enhanced.	propargylglycine	63-82	cystathionine beta-synthase	Homo sapiens	199-226
21952317-4	2011	Under this hypoxic condition, when the cells were treated with DL-propargylglycine (PPG) and aminooxyacetic acid (AOAA), a specific inhibitor of H(2)S synthase of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) respectively, radiation responses including cell killing, micronuclei (MN) formation, and caspase-3 activity were significantly enhanced.	propargylglycine	63-82	cystathionine beta-synthase	Homo sapiens	228-231
21952317-4	2011	Under this hypoxic condition, when the cells were treated with DL-propargylglycine (PPG) and aminooxyacetic acid (AOAA), a specific inhibitor of H(2)S synthase of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) respectively, radiation responses including cell killing, micronuclei (MN) formation, and caspase-3 activity were significantly enhanced.	propargylglycine	84-87	cystathionine beta-synthase	Homo sapiens	199-226
21952317-4	2011	Under this hypoxic condition, when the cells were treated with DL-propargylglycine (PPG) and aminooxyacetic acid (AOAA), a specific inhibitor of H(2)S synthase of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) respectively, radiation responses including cell killing, micronuclei (MN) formation, and caspase-3 activity were significantly enhanced.	propargylglycine	84-87	cystathionine beta-synthase	Homo sapiens	228-231
21952317-4	2011	Under this hypoxic condition, when the cells were treated with DL-propargylglycine (PPG) and aminooxyacetic acid (AOAA), a specific inhibitor of H(2)S synthase of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) respectively, radiation responses including cell killing, micronuclei (MN) formation, and caspase-3 activity were significantly enhanced.	Aminooxyacetic Acid	114-118	cystathionine beta-synthase	Homo sapiens	199-226
21952317-4	2011	Under this hypoxic condition, when the cells were treated with DL-propargylglycine (PPG) and aminooxyacetic acid (AOAA), a specific inhibitor of H(2)S synthase of cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthase (CBS) respectively, radiation responses including cell killing, micronuclei (MN) formation, and caspase-3 activity were significantly enhanced.	Aminooxyacetic Acid	114-118	cystathionine beta-synthase	Homo sapiens	228-231
21512302-3	2011	H(2)S can be produced in pancreatic beta-cells by cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	0-5	cystathionine beta-synthase	Homo sapiens	50-77
21128616-1	2010	The mechanisms for the reactions of ClO with C(2)H(2) and C(2)H(4) have been investigated at the CCSD(T)/CBS level of theory.	clo	36-39	cystathionine beta-synthase	Homo sapiens	105-108
21886822-5	2011	Immunohistochemistry analysis showed that cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthetase (CBS), the principle enzymes responsible for H(2)S generation, were mainly localized to smooth muscle cells of human pregnant myometrium.	2)s	155-158	cystathionine beta-synthase	Homo sapiens	78-107
21886822-5	2011	Immunohistochemistry analysis showed that cystathionine-gamma-lyase (CSE) and cystathionine-beta-synthetase (CBS), the principle enzymes responsible for H(2)S generation, were mainly localized to smooth muscle cells of human pregnant myometrium.	2)s	155-158	cystathionine beta-synthase	Homo sapiens	109-112
21128616-1	2010	The mechanisms for the reactions of ClO with C(2)H(2) and C(2)H(4) have been investigated at the CCSD(T)/CBS level of theory.	c(2)h	45-50	cystathionine beta-synthase	Homo sapiens	105-108
21128616-1	2010	The mechanisms for the reactions of ClO with C(2)H(2) and C(2)H(4) have been investigated at the CCSD(T)/CBS level of theory.	c(2)h	58-63	cystathionine beta-synthase	Homo sapiens	105-108
20973022-8	2010	CBS-Q incorrectly predicts equal or even higher binding enthalpies for PhSH than for PhOH, which invalidates it as a benchmark for other calculations.	Phenol	85-89	cystathionine beta-synthase	Homo sapiens	0-3
20941421-0	2010	Rational electronic tuning of CBS catalyst for highly enantioselective borane reduction of trifluoroacetophenone.	phenyl trifluoromethyl ketone	91-112	cystathionine beta-synthase	Homo sapiens	30-33
20941421-1	2010	alpha,alpha,alpha-Trifluoroacetophenone (2), which is susceptible to noncatalytic reduction by BH(3), could be reduced to chiral alcohol up to 90% ee by using electronically tuned-CBS catalyst (1) with BH(3).	phenyl trifluoromethyl ketone	0-39	cystathionine beta-synthase	Homo sapiens	180-183
20941421-1	2010	alpha,alpha,alpha-Trifluoroacetophenone (2), which is susceptible to noncatalytic reduction by BH(3), could be reduced to chiral alcohol up to 90% ee by using electronically tuned-CBS catalyst (1) with BH(3).	Alcohols	129-136	cystathionine beta-synthase	Homo sapiens	180-183
20502969-6	2010	To investigate this, we determined protein and mRNA expression of the H(2)S-producing enzymes cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS), H(2)S production rates in the aorta and liver, and the contractile response of aortic rings to exogenous H(2)S.	Hydrogen Sulfide	70-75	cystathionine beta-synthase	Homo sapiens	130-157
20939734-1	2010	AIM: Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS) genes, involved in the intracellular metabolism of homcysteine, can result in hyperhomocysteinemia.	homcysteine	159-170	cystathionine beta-synthase	Homo sapiens	74-101
20939734-1	2010	AIM: Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS) genes, involved in the intracellular metabolism of homcysteine, can result in hyperhomocysteinemia.	homcysteine	159-170	cystathionine beta-synthase	Homo sapiens	103-106
20627200-6	2010	Cystathionine beta-synthase (CBS) catalyzes a major removal pathway of homocysteine and is dependent on both PLP and heme as cofactors.	Homocysteine	71-83	cystathionine beta-synthase	Homo sapiens	0-27
20627200-6	2010	Cystathionine beta-synthase (CBS) catalyzes a major removal pathway of homocysteine and is dependent on both PLP and heme as cofactors.	Homocysteine	71-83	cystathionine beta-synthase	Homo sapiens	29-32
20627200-6	2010	Cystathionine beta-synthase (CBS) catalyzes a major removal pathway of homocysteine and is dependent on both PLP and heme as cofactors.	Heme	117-121	cystathionine beta-synthase	Homo sapiens	0-27
20627200-6	2010	Cystathionine beta-synthase (CBS) catalyzes a major removal pathway of homocysteine and is dependent on both PLP and heme as cofactors.	Heme	117-121	cystathionine beta-synthase	Homo sapiens	29-32
20627200-7	2010	It is hypothesized that, in AIP, CBS reduced hepatic activity resulting from either a low heme status and/or consumptive depletion of PLP due to increased demand by 5-aminolevulinatesynthase hyperactivity can induce hyperhomocysteinemia.	Heme	90-94	cystathionine beta-synthase	Homo sapiens	33-36
21172066-4	2010	Moreover NGAL levels increase in correlation with the age, and showed a significantly correlation between the increase with the severity of disease.DS is characterized by an enhancement of gene production such as GART, SOD-1 and CBS that encode specific protein and enzyme involved in hydrogen peroxide and superoxide production, species highly cytotoxic implicated in inflammation and ageing.NGAL may have the potential application to ameliorate the toxicity induced by oxidative stress conditions such as Alzheimer"s disease, thalassemia, cardiovascular disease, burn injury, transplantation, diabetes, and aging.	Hydrogen Peroxide	285-302	cystathionine beta-synthase	Homo sapiens	229-232
21172066-4	2010	Moreover NGAL levels increase in correlation with the age, and showed a significantly correlation between the increase with the severity of disease.DS is characterized by an enhancement of gene production such as GART, SOD-1 and CBS that encode specific protein and enzyme involved in hydrogen peroxide and superoxide production, species highly cytotoxic implicated in inflammation and ageing.NGAL may have the potential application to ameliorate the toxicity induced by oxidative stress conditions such as Alzheimer"s disease, thalassemia, cardiovascular disease, burn injury, transplantation, diabetes, and aging.	Superoxides	307-317	cystathionine beta-synthase	Homo sapiens	229-232
21062078-1	2010	Cystathionine beta-synthase (CBS) is a modular enzyme which catalyzes condensation of serine with homocysteine.	Serine	86-92	cystathionine beta-synthase	Homo sapiens	0-27
21062078-1	2010	Cystathionine beta-synthase (CBS) is a modular enzyme which catalyzes condensation of serine with homocysteine.	Serine	86-92	cystathionine beta-synthase	Homo sapiens	29-32
21062078-1	2010	Cystathionine beta-synthase (CBS) is a modular enzyme which catalyzes condensation of serine with homocysteine.	Homocysteine	98-110	cystathionine beta-synthase	Homo sapiens	0-27
21062078-1	2010	Cystathionine beta-synthase (CBS) is a modular enzyme which catalyzes condensation of serine with homocysteine.	Homocysteine	98-110	cystathionine beta-synthase	Homo sapiens	29-32
20825409-1	2010	BACKGROUND AND PURPOSE: Hydrogen sulphide (H(2)S), considered as a novel gas transmitter, is produced endogenously in mammalian tissue from L-cysteine by two enzymes, cystathionine beta-synthase and cystathionine gamma-lyase.	Hydrogen Sulfide	24-41	cystathionine beta-synthase	Homo sapiens	167-194
20825409-1	2010	BACKGROUND AND PURPOSE: Hydrogen sulphide (H(2)S), considered as a novel gas transmitter, is produced endogenously in mammalian tissue from L-cysteine by two enzymes, cystathionine beta-synthase and cystathionine gamma-lyase.	Hydrogen Sulfide	43-49	cystathionine beta-synthase	Homo sapiens	167-194
20825409-1	2010	BACKGROUND AND PURPOSE: Hydrogen sulphide (H(2)S), considered as a novel gas transmitter, is produced endogenously in mammalian tissue from L-cysteine by two enzymes, cystathionine beta-synthase and cystathionine gamma-lyase.	Cysteine	140-150	cystathionine beta-synthase	Homo sapiens	167-194
20545623-2	2010	H2S is synthesized from L-cysteine by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), or by sequential action of alanine aminotransferase and 3-mercaptopyruvate sulfurtransferase.	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	38-65
20817827-3	2010	Here we show that the transsulfuration enzymes, cystathionine beta-synthase and cystathionine gamma-lyase, are secreted by microvascular endothelial cells and hepatocytes, circulate as members of the plasma proteome, and actively produce hydrogen sulfide from homocysteine in human blood.	Hydrogen Sulfide	238-254	cystathionine beta-synthase	Homo sapiens	48-75
20817827-3	2010	Here we show that the transsulfuration enzymes, cystathionine beta-synthase and cystathionine gamma-lyase, are secreted by microvascular endothelial cells and hepatocytes, circulate as members of the plasma proteome, and actively produce hydrogen sulfide from homocysteine in human blood.	Homocysteine	260-272	cystathionine beta-synthase	Homo sapiens	48-75
21117445-2	2010	H2S is synthesized in various body-systems using the enzymes cystathionine beta-synthase and cystathionine gamma-lyase; either of these being the predominat enzyme in a particular system.	Deuterium	0-3	cystathionine beta-synthase	Homo sapiens	61-88
22419938-1	2010	INTRODUCTION: Susceptibility to head and neck squamous cell carcinoma may be modified by functional polymorphisms in genes involved in the folate pathway, such as cystathionine beta-synthase (CBS).	Folic Acid	139-145	cystathionine beta-synthase	Homo sapiens	163-190
22419938-1	2010	INTRODUCTION: Susceptibility to head and neck squamous cell carcinoma may be modified by functional polymorphisms in genes involved in the folate pathway, such as cystathionine beta-synthase (CBS).	Folic Acid	139-145	cystathionine beta-synthase	Homo sapiens	192-195
20831237-3	2010	The highly accurate CCSD(T)/complete basis set (CBS) value of the interaction energy for the model diborane   benzene complex in a stacking geometry exhibiting a B(2)H   pi hydrogen bond was calculated to be -4.0 kcal mol(-1).	diborane   benzene	99-117	cystathionine beta-synthase	Homo sapiens	48-51
20831237-3	2010	The highly accurate CCSD(T)/complete basis set (CBS) value of the interaction energy for the model diborane   benzene complex in a stacking geometry exhibiting a B(2)H   pi hydrogen bond was calculated to be -4.0 kcal mol(-1).	Hydrogen	173-181	cystathionine beta-synthase	Homo sapiens	48-51
20545623-2	2010	H2S is synthesized from L-cysteine by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), or by sequential action of alanine aminotransferase and 3-mercaptopyruvate sulfurtransferase.	Hydrogen Sulfide	0-3	cystathionine beta-synthase	Homo sapiens	67-70
20545623-2	2010	H2S is synthesized from L-cysteine by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), or by sequential action of alanine aminotransferase and 3-mercaptopyruvate sulfurtransferase.	Cysteine	24-34	cystathionine beta-synthase	Homo sapiens	38-65
20545623-2	2010	H2S is synthesized from L-cysteine by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), or by sequential action of alanine aminotransferase and 3-mercaptopyruvate sulfurtransferase.	Cysteine	24-34	cystathionine beta-synthase	Homo sapiens	67-70
20735429-6	2010	Exogenous application of NaHS (an H(2)S donor, 100-1000 microM) or overexpression of cystathionine beta-synthase (a predominant enzyme to produce endogenous H(2)S in SH-SY5Y cells) protected cells against 6-OHDA-induced cell apoptosis and death.	Hydrogen Sulfide	157-162	cystathionine beta-synthase	Homo sapiens	85-112
20735429-6	2010	Exogenous application of NaHS (an H(2)S donor, 100-1000 microM) or overexpression of cystathionine beta-synthase (a predominant enzyme to produce endogenous H(2)S in SH-SY5Y cells) protected cells against 6-OHDA-induced cell apoptosis and death.	Oxidopamine	205-211	cystathionine beta-synthase	Homo sapiens	85-112
20609606-6	2010	Firstly, structures and energies of isomers of the tripeptide Phe-Gly-Phe have been compared with CCSD(T)/CBS//RI-MP2/cc-pVTZ literature values.	tripeptide K-26	51-61	cystathionine beta-synthase	Homo sapiens	106-109
20440442-1	2010	Endogenous hydrogen sulfide (H(2)S) is naturally synthesized in many types of mammalian cells from L-cysteine in the reactions catalyzed by cystathionine-beta-synthase and cystathionine-gamma-lyase (CSE).	Hydrogen Sulfide	11-27	cystathionine beta-synthase	Homo sapiens	140-167
20797558-3	2010	Cystathionine beta-synthase, cystathionine gamma-lyase, and 3-mercaptopyruvate sulfurtransferase catalyze H(2)S formation.	Hydrogen Sulfide	106-111	cystathionine beta-synthase	Homo sapiens	0-27
20440442-1	2010	Endogenous hydrogen sulfide (H(2)S) is naturally synthesized in many types of mammalian cells from L-cysteine in the reactions catalyzed by cystathionine-beta-synthase and cystathionine-gamma-lyase (CSE).	Hydrogen Sulfide	29-34	cystathionine beta-synthase	Homo sapiens	140-167
20440442-1	2010	Endogenous hydrogen sulfide (H(2)S) is naturally synthesized in many types of mammalian cells from L-cysteine in the reactions catalyzed by cystathionine-beta-synthase and cystathionine-gamma-lyase (CSE).	Cysteine	99-109	cystathionine beta-synthase	Homo sapiens	140-167
20670920-0	2010	Association of genetic variation in cystathionine-beta-synthase and arsenic metabolism.	Arsenic	68-75	cystathionine beta-synthase	Homo sapiens	36-63
20714314-1	2010	Lanthionine (Lan), the thioether analog of cystine, is a natural but nonproteogenic amino acid thought to form naturally in mammals through promiscuous reactivity of the transsulfuration enzyme cystathionine-beta-synthase (CbetaS).	lanthionine	0-11	cystathionine beta-synthase	Homo sapiens	194-221
20714314-1	2010	Lanthionine (Lan), the thioether analog of cystine, is a natural but nonproteogenic amino acid thought to form naturally in mammals through promiscuous reactivity of the transsulfuration enzyme cystathionine-beta-synthase (CbetaS).	lanthionine	0-3	cystathionine beta-synthase	Homo sapiens	194-221
20714314-1	2010	Lanthionine (Lan), the thioether analog of cystine, is a natural but nonproteogenic amino acid thought to form naturally in mammals through promiscuous reactivity of the transsulfuration enzyme cystathionine-beta-synthase (CbetaS).	Sulfides	23-32	cystathionine beta-synthase	Homo sapiens	194-221
20714314-1	2010	Lanthionine (Lan), the thioether analog of cystine, is a natural but nonproteogenic amino acid thought to form naturally in mammals through promiscuous reactivity of the transsulfuration enzyme cystathionine-beta-synthase (CbetaS).	Cystine	43-50	cystathionine beta-synthase	Homo sapiens	194-221
20670920-4	2010	In 142 subjects in Cordoba Province, Argentina, variant genotypes for CBS rs234709 and rs4920037 SNPs compared with wild-type homozygotes were associated with 24% and 26% increases, respectively, in the mean proportion of arsenic excreted as monomethylarsonic acid (%MMA).	Arsenic	222-229	cystathionine beta-synthase	Homo sapiens	70-73
20670920-4	2010	In 142 subjects in Cordoba Province, Argentina, variant genotypes for CBS rs234709 and rs4920037 SNPs compared with wild-type homozygotes were associated with 24% and 26% increases, respectively, in the mean proportion of arsenic excreted as monomethylarsonic acid (%MMA).	monomethylarsonic acid	242-264	cystathionine beta-synthase	Homo sapiens	70-73
20670920-4	2010	In 142 subjects in Cordoba Province, Argentina, variant genotypes for CBS rs234709 and rs4920037 SNPs compared with wild-type homozygotes were associated with 24% and 26% increases, respectively, in the mean proportion of arsenic excreted as monomethylarsonic acid (%MMA).	mma	267-270	cystathionine beta-synthase	Homo sapiens	70-73
20670920-6	2010	Small inverse associations with CBS rs234709 and rs4920037 variants were also found for the mean levels of the proportion of arsenic excreted as dimethylarsinous acid (%DMA).	Arsenic	125-132	cystathionine beta-synthase	Homo sapiens	32-35
20670920-6	2010	Small inverse associations with CBS rs234709 and rs4920037 variants were also found for the mean levels of the proportion of arsenic excreted as dimethylarsinous acid (%DMA).	dimethylarsinous acid	145-166	cystathionine beta-synthase	Homo sapiens	32-35
20670920-6	2010	Small inverse associations with CBS rs234709 and rs4920037 variants were also found for the mean levels of the proportion of arsenic excreted as dimethylarsinous acid (%DMA).	N-myristoyl-alaninol	169-172	cystathionine beta-synthase	Homo sapiens	32-35
20670920-8	2010	These findings are the first to suggest that CBS polymorphisms may influence arsenic metabolism in humans and susceptibility to arsenic-related disease.	Arsenic	77-84	cystathionine beta-synthase	Homo sapiens	45-48
20670920-8	2010	These findings are the first to suggest that CBS polymorphisms may influence arsenic metabolism in humans and susceptibility to arsenic-related disease.	Arsenic	128-135	cystathionine beta-synthase	Homo sapiens	45-48
20506325-3	2010	The median amount of SDS-soluble mutant CBS polypeptides in the pellet after centrifugation of bacterial extracts was increased by 50% compared to the wild type.	Sodium Dodecyl Sulfate	21-24	cystathionine beta-synthase	Homo sapiens	40-43
20428536-7	2010	We propose a scheme to derive CCSD(T)/Complete Basis Set (CBS) quality binding energies for the C4A-Ar complex based on CCSD(T) calculations with smaller basis sets and the ratio of CCSD(T)/MP2 energies for the smaller model systems benzene-Ar and phenol-Ar, for which the CCSD(T) level of theory converges to the experimentally determined binding energies.	Benzene	233-240	cystathionine beta-synthase	Homo sapiens	58-61
20455263-5	2010	Yeast missing this enzyme cannot grow on medium lacking a source of cysteine, while transfection of functional human CBS into yeast strains missing endogenous enzyme can successfully complement for the missing gene.	Cysteine	68-76	cystathionine beta-synthase	Homo sapiens	117-120
20428536-7	2010	We propose a scheme to derive CCSD(T)/Complete Basis Set (CBS) quality binding energies for the C4A-Ar complex based on CCSD(T) calculations with smaller basis sets and the ratio of CCSD(T)/MP2 energies for the smaller model systems benzene-Ar and phenol-Ar, for which the CCSD(T) level of theory converges to the experimentally determined binding energies.	Phenol	248-254	cystathionine beta-synthase	Homo sapiens	58-61
20175737-2	2010	We have analysed the association of the CBS 844Ins68 polymorphism alone and in combination with methylenetetrahydrofolate reductase (MTHFR C677T) and choline dehydrogenase (CHDH A119C) polymorphisms (the two polymorphisms recently shown to be associated with levels of homocysteine) with homocysteine, cysteine, folate and vitamin B(12) in 817 individuals (397 patients with coronary artery disease and 420 controls).	Homocysteine	269-281	cystathionine beta-synthase	Homo sapiens	40-43
19803743-3	2010	In 1996 we demonstrated that cystathionine beta-synthase (CBS) is a H(2)S producing enzyme in the brain and that H(2)S enhances the activity of NMDA receptors and facilitates the induction of hippocampal long-term potentiation (LTP), a synaptic model of memory.	Hydrogen Sulfide	68-73	cystathionine beta-synthase	Homo sapiens	29-56
19803743-3	2010	In 1996 we demonstrated that cystathionine beta-synthase (CBS) is a H(2)S producing enzyme in the brain and that H(2)S enhances the activity of NMDA receptors and facilitates the induction of hippocampal long-term potentiation (LTP), a synaptic model of memory.	Hydrogen Sulfide	68-73	cystathionine beta-synthase	Homo sapiens	58-61
19803743-3	2010	In 1996 we demonstrated that cystathionine beta-synthase (CBS) is a H(2)S producing enzyme in the brain and that H(2)S enhances the activity of NMDA receptors and facilitates the induction of hippocampal long-term potentiation (LTP), a synaptic model of memory.	Hydrogen Sulfide	113-118	cystathionine beta-synthase	Homo sapiens	29-56
19803743-3	2010	In 1996 we demonstrated that cystathionine beta-synthase (CBS) is a H(2)S producing enzyme in the brain and that H(2)S enhances the activity of NMDA receptors and facilitates the induction of hippocampal long-term potentiation (LTP), a synaptic model of memory.	Hydrogen Sulfide	113-118	cystathionine beta-synthase	Homo sapiens	58-61
19803745-2	2010	H(2)S can be endogenously produced by cystathionine gamma-lyase (CSE) or cystathionine beta-synthase (CBS) or both in colonic tissues.	Hydrogen Sulfide	0-5	cystathionine beta-synthase	Homo sapiens	73-100
20175737-2	2010	We have analysed the association of the CBS 844Ins68 polymorphism alone and in combination with methylenetetrahydrofolate reductase (MTHFR C677T) and choline dehydrogenase (CHDH A119C) polymorphisms (the two polymorphisms recently shown to be associated with levels of homocysteine) with homocysteine, cysteine, folate and vitamin B(12) in 817 individuals (397 patients with coronary artery disease and 420 controls).	Cysteine	273-281	cystathionine beta-synthase	Homo sapiens	40-43
20175737-2	2010	We have analysed the association of the CBS 844Ins68 polymorphism alone and in combination with methylenetetrahydrofolate reductase (MTHFR C677T) and choline dehydrogenase (CHDH A119C) polymorphisms (the two polymorphisms recently shown to be associated with levels of homocysteine) with homocysteine, cysteine, folate and vitamin B(12) in 817 individuals (397 patients with coronary artery disease and 420 controls).	Niacinamide	323-332	cystathionine beta-synthase	Homo sapiens	40-43
20450253-9	2010	Both the inhibitor of cystathionine beta-synthase, AOA (30 microM) and the K(ATP) channel antagonist, glibenclamide (100 microM) caused significant (P &lt; 0.001) rightward shifts in the concentration-response curves to L-cysteine and attenuated the maximum inhibitory response.	Cysteine	220-230	cystathionine beta-synthase	Homo sapiens	22-49
20450253-11	2010	CONCLUSIONS: The inhibitory action of L-cysteine in isolated porcine irides is dependent on the endogenous production of H(2)S by cystathionine gamma-lyase and cystathionine beta-synthase.	Cysteine	38-48	cystathionine beta-synthase	Homo sapiens	160-187
19594435-0	2010	Mutagenesis studies of human cystathionine beta-synthase: residues important for heme binding and substrate interactions.	Heme	81-85	cystathionine beta-synthase	Homo sapiens	29-56
20155941-2	2010	CBS is a pyridoxal-5"-phosphate-dependent heme enzyme with cysteine and histidine axial ligands that catalyzes the condensation of serine and homocysteine to form cystathionine.	Pyridoxal Phosphate	9-31	cystathionine beta-synthase	Homo sapiens	0-3
20155941-2	2010	CBS is a pyridoxal-5"-phosphate-dependent heme enzyme with cysteine and histidine axial ligands that catalyzes the condensation of serine and homocysteine to form cystathionine.	Cysteine	59-67	cystathionine beta-synthase	Homo sapiens	0-3
20155941-2	2010	CBS is a pyridoxal-5"-phosphate-dependent heme enzyme with cysteine and histidine axial ligands that catalyzes the condensation of serine and homocysteine to form cystathionine.	Histidine	72-81	cystathionine beta-synthase	Homo sapiens	0-3
20155941-2	2010	CBS is a pyridoxal-5"-phosphate-dependent heme enzyme with cysteine and histidine axial ligands that catalyzes the condensation of serine and homocysteine to form cystathionine.	Serine	131-137	cystathionine beta-synthase	Homo sapiens	0-3
20336251-0	2010	Reference MP2/CBS and CCSD(T) quantum-chemical calculations on stacked adenine dimers.	Adenine	71-78	cystathionine beta-synthase	Homo sapiens	14-17
20331285-0	2010	MP2/CBS atomic and molecular benchmarks for H through Ar.	Argon	54-56	cystathionine beta-synthase	Homo sapiens	4-7
20155960-0	2010	Boryl substitution of acetaldehyde makes it an enol: inconsistency between Gn/CBS and ab initio/DFT data.	boryl	0-5	cystathionine beta-synthase	Homo sapiens	78-81
20155960-0	2010	Boryl substitution of acetaldehyde makes it an enol: inconsistency between Gn/CBS and ab initio/DFT data.	Acetaldehyde	22-34	cystathionine beta-synthase	Homo sapiens	78-81
20155960-3	2010	Gn/CBS methods provide a qualitatively different description of tautomeric (keto-enol) equilibrium in 2-substituted acetaldehydes.	keto-enol	76-85	cystathionine beta-synthase	Homo sapiens	3-6
20155960-3	2010	Gn/CBS methods provide a qualitatively different description of tautomeric (keto-enol) equilibrium in 2-substituted acetaldehydes.	2-substituted acetaldehydes	102-129	cystathionine beta-synthase	Homo sapiens	3-6
20155960-7	2010	The relative energy of alkenol, CH(BH(2))=CH(OH), is calculated to be -1.67 +/- 0.82 kcal mol(-1) at CCSD(T)/CBS level of theory.	alkenol	23-30	cystathionine beta-synthase	Homo sapiens	109-112
20155941-2	2010	CBS is a pyridoxal-5"-phosphate-dependent heme enzyme with cysteine and histidine axial ligands that catalyzes the condensation of serine and homocysteine to form cystathionine.	Homocysteine	142-154	cystathionine beta-synthase	Homo sapiens	0-3
20155941-2	2010	CBS is a pyridoxal-5"-phosphate-dependent heme enzyme with cysteine and histidine axial ligands that catalyzes the condensation of serine and homocysteine to form cystathionine.	Cystathionine	163-176	cystathionine beta-synthase	Homo sapiens	0-3
20155941-4	2010	Normal coordinate structural decomposition (NSD) of the ferric CBS crystal structure predicts the enhancement of normal modes with significant heme "doming", "ruffling", and "saddling" content, and they are observed in the coherence spectra near approximately 40, approximately 60, and approximately 90 cm(-1).	Ferric enterobactin ion	56-62	cystathionine beta-synthase	Homo sapiens	63-66
20155941-4	2010	Normal coordinate structural decomposition (NSD) of the ferric CBS crystal structure predicts the enhancement of normal modes with significant heme "doming", "ruffling", and "saddling" content, and they are observed in the coherence spectra near approximately 40, approximately 60, and approximately 90 cm(-1).	Heme	143-147	cystathionine beta-synthase	Homo sapiens	63-66
20155941-6	2010	For ferric CBS, we observe a new mode near approximately 25 cm(-1), possibly involving the response of the protein, which exhibits a phase jump of approximately pi for excitation on the blue and red side of the Soret band maximum.	Ferric enterobactin ion	4-10	cystathionine beta-synthase	Homo sapiens	11-14
19594435-1	2010	Human cystathionine beta-synthase (CBS) is a pyridoxal 5"-phosphate (PLP) dependent hemoprotein, which catalyzes the condensation of serine and homocysteine.	Serine	133-139	cystathionine beta-synthase	Homo sapiens	6-33
19594435-1	2010	Human cystathionine beta-synthase (CBS) is a pyridoxal 5"-phosphate (PLP) dependent hemoprotein, which catalyzes the condensation of serine and homocysteine.	Homocysteine	144-156	cystathionine beta-synthase	Homo sapiens	6-33
19960509-2	2010	In addition to confirming these findings, we further found that ATRA repressed the expression of betaine-homocysteine methyltransferase (BHMT) and cystathionine-beta-synthase (CBS), which are key enzymes that are involved in homocysteine metabolism, increased the level of intracellular homocysteine, and decreased the glutathione (GSH) level in GnT-V-AS/7721 cells.	Tretinoin	64-68	cystathionine beta-synthase	Homo sapiens	147-174
19960509-2	2010	In addition to confirming these findings, we further found that ATRA repressed the expression of betaine-homocysteine methyltransferase (BHMT) and cystathionine-beta-synthase (CBS), which are key enzymes that are involved in homocysteine metabolism, increased the level of intracellular homocysteine, and decreased the glutathione (GSH) level in GnT-V-AS/7721 cells.	Glutathione	332-335	cystathionine beta-synthase	Homo sapiens	147-174
20026078-0	2010	Binding of S-methyl-5"-thioadenosine and S-adenosyl-L-methionine to protein MJ0100 triggers an open-to-closed conformational change in its CBS motif pair.	5'-methylthioadenosine	11-36	cystathionine beta-synthase	Homo sapiens	139-142
20026078-0	2010	Binding of S-methyl-5"-thioadenosine and S-adenosyl-L-methionine to protein MJ0100 triggers an open-to-closed conformational change in its CBS motif pair.	S-Adenosylmethionine	41-64	cystathionine beta-synthase	Homo sapiens	139-142
20026078-4	2010	This work presents the crystallographic analysis of four different states of the CBS motif pair of MJ0100 in complex with different numbers of S-adenosyl-L-methionine (SAM) and S-methyl-5"-thioadenosine (MTA) ligands, providing evidence that ligand-induced conformational reorganization of Bateman domain dimers could be an important regulatory mechanism.	S-Adenosylmethionine	143-166	cystathionine beta-synthase	Homo sapiens	81-84
20026078-4	2010	This work presents the crystallographic analysis of four different states of the CBS motif pair of MJ0100 in complex with different numbers of S-adenosyl-L-methionine (SAM) and S-methyl-5"-thioadenosine (MTA) ligands, providing evidence that ligand-induced conformational reorganization of Bateman domain dimers could be an important regulatory mechanism.	S-Adenosylmethionine	168-171	cystathionine beta-synthase	Homo sapiens	81-84
20026078-4	2010	This work presents the crystallographic analysis of four different states of the CBS motif pair of MJ0100 in complex with different numbers of S-adenosyl-L-methionine (SAM) and S-methyl-5"-thioadenosine (MTA) ligands, providing evidence that ligand-induced conformational reorganization of Bateman domain dimers could be an important regulatory mechanism.	5'-methylthioadenosine	177-202	cystathionine beta-synthase	Homo sapiens	81-84
19960509-2	2010	In addition to confirming these findings, we further found that ATRA repressed the expression of betaine-homocysteine methyltransferase (BHMT) and cystathionine-beta-synthase (CBS), which are key enzymes that are involved in homocysteine metabolism, increased the level of intracellular homocysteine, and decreased the glutathione (GSH) level in GnT-V-AS/7721 cells.	Glutathione	319-330	cystathionine beta-synthase	Homo sapiens	147-174
20026078-4	2010	This work presents the crystallographic analysis of four different states of the CBS motif pair of MJ0100 in complex with different numbers of S-adenosyl-L-methionine (SAM) and S-methyl-5"-thioadenosine (MTA) ligands, providing evidence that ligand-induced conformational reorganization of Bateman domain dimers could be an important regulatory mechanism.	5'-methylthioadenosine	204-207	cystathionine beta-synthase	Homo sapiens	81-84
20066033-3	2010	Here, we extend these studies and show that it is possible to restore significant levels of enzyme activity to 17 of 18 (94%) disease causing missense mutations in human cystathionine beta-synthase (CBS) expressed in Saccharomyces cerevisiae by exposure to ethanol, proteasome inhibitors, or deletion of the Hsp26 small heat shock protein.	Ethanol	257-264	cystathionine beta-synthase	Homo sapiens	170-197
20066033-3	2010	Here, we extend these studies and show that it is possible to restore significant levels of enzyme activity to 17 of 18 (94%) disease causing missense mutations in human cystathionine beta-synthase (CBS) expressed in Saccharomyces cerevisiae by exposure to ethanol, proteasome inhibitors, or deletion of the Hsp26 small heat shock protein.	Ethanol	257-264	cystathionine beta-synthase	Homo sapiens	199-202
20559280-2	2010	Molecular-genetic studies revealed the association between schizophrenia and polymorphisms of two genes - methylenetetrahydrofolate reductase (MTHFR) and cystathionine-beta-synthase (CBS) involved in the conversion of homocysteine to methionine and cysteine, respectively.	Homocysteine	218-230	cystathionine beta-synthase	Homo sapiens	154-181
20559280-2	2010	Molecular-genetic studies revealed the association between schizophrenia and polymorphisms of two genes - methylenetetrahydrofolate reductase (MTHFR) and cystathionine-beta-synthase (CBS) involved in the conversion of homocysteine to methionine and cysteine, respectively.	Methionine	234-244	cystathionine beta-synthase	Homo sapiens	154-181
19733148-0	2009	Inactivation of cystathionine beta-synthase with peroxynitrite.	Peroxynitrous Acid	49-62	cystathionine beta-synthase	Homo sapiens	16-43
20559280-2	2010	Molecular-genetic studies revealed the association between schizophrenia and polymorphisms of two genes - methylenetetrahydrofolate reductase (MTHFR) and cystathionine-beta-synthase (CBS) involved in the conversion of homocysteine to methionine and cysteine, respectively.	Cysteine	222-230	cystathionine beta-synthase	Homo sapiens	154-181
19956742-5	2009	CONCLUSIONS/SIGNIFICANCE: Our results reveal a novel connection between a key sulfur metabolic enzyme, CBS, and the cell cycle.	Sulfur	78-84	cystathionine beta-synthase	Homo sapiens	103-106
19733148-2	2009	CBS was inactivated by peroxynitrite, the product of nitric oxide and superoxide radicals.	Nitric Oxide	53-65	cystathionine beta-synthase	Homo sapiens	0-3
19906435-2	2009	Cystathionine-beta-synthase (CBS) is a key enzyme related to homocysteine levels.	Homocysteine	61-73	cystathionine beta-synthase	Homo sapiens	0-27
19906435-2	2009	Cystathionine-beta-synthase (CBS) is a key enzyme related to homocysteine levels.	Homocysteine	61-73	cystathionine beta-synthase	Homo sapiens	29-32
20361707-4	2009	Although HHcy causes heart failure, interestingly, it is becoming very clear that Hcy can generate hydrogen sulfide (H2S), if the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) are present.	Homocysteine	10-13	cystathionine beta-synthase	Homo sapiens	138-165
20361707-4	2009	Although HHcy causes heart failure, interestingly, it is becoming very clear that Hcy can generate hydrogen sulfide (H2S), if the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) are present.	Hydrogen Sulfide	99-115	cystathionine beta-synthase	Homo sapiens	138-165
20361707-4	2009	Although HHcy causes heart failure, interestingly, it is becoming very clear that Hcy can generate hydrogen sulfide (H2S), if the enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) are present.	Hydrogen Sulfide	117-120	cystathionine beta-synthase	Homo sapiens	138-165
19593657-1	2009	Cystathionine beta synthase (CBS) is the only reaction that removes homocysteine from methionine cycle and redirects it to the transsulfuration pathway.	Homocysteine	68-80	cystathionine beta-synthase	Homo sapiens	0-27
19593657-1	2009	Cystathionine beta synthase (CBS) is the only reaction that removes homocysteine from methionine cycle and redirects it to the transsulfuration pathway.	Homocysteine	68-80	cystathionine beta-synthase	Homo sapiens	29-32
19593657-1	2009	Cystathionine beta synthase (CBS) is the only reaction that removes homocysteine from methionine cycle and redirects it to the transsulfuration pathway.	Methionine	86-96	cystathionine beta-synthase	Homo sapiens	0-27
19593657-1	2009	Cystathionine beta synthase (CBS) is the only reaction that removes homocysteine from methionine cycle and redirects it to the transsulfuration pathway.	Methionine	86-96	cystathionine beta-synthase	Homo sapiens	29-32
19654230-3	2009	Cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulphurtransferase (MPS) catalyze H(2)S formation, with different relative efficiencies.	Hydrogen Sulfide	124-129	cystathionine beta-synthase	Homo sapiens	0-27
19654230-3	2009	Cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulphurtransferase (MPS) catalyze H(2)S formation, with different relative efficiencies.	Hydrogen Sulfide	124-129	cystathionine beta-synthase	Homo sapiens	29-32
19733148-2	2009	CBS was inactivated by peroxynitrite, the product of nitric oxide and superoxide radicals.	Superoxides	70-80	cystathionine beta-synthase	Homo sapiens	0-3
19733148-5	2009	The radicals derived from peroxynitrite, nitrogen dioxide and carbonate radical, also inactivated CBS.	Peroxynitrous Acid	26-39	cystathionine beta-synthase	Homo sapiens	98-101
19733148-1	2009	Cystathionine beta-synthase (CBS) is a homocysteine metabolizing enzyme that contains pyridoxal phosphate (PLP) and a six-coordinate heme cofactor of unknown function.	Homocysteine	39-51	cystathionine beta-synthase	Homo sapiens	0-27
19733148-1	2009	Cystathionine beta-synthase (CBS) is a homocysteine metabolizing enzyme that contains pyridoxal phosphate (PLP) and a six-coordinate heme cofactor of unknown function.	Homocysteine	39-51	cystathionine beta-synthase	Homo sapiens	29-32
19733148-5	2009	The radicals derived from peroxynitrite, nitrogen dioxide and carbonate radical, also inactivated CBS.	Nitrogen Dioxide	41-57	cystathionine beta-synthase	Homo sapiens	98-101
19733148-1	2009	Cystathionine beta-synthase (CBS) is a homocysteine metabolizing enzyme that contains pyridoxal phosphate (PLP) and a six-coordinate heme cofactor of unknown function.	Pyridoxal Phosphate	86-105	cystathionine beta-synthase	Homo sapiens	0-27
19733148-1	2009	Cystathionine beta-synthase (CBS) is a homocysteine metabolizing enzyme that contains pyridoxal phosphate (PLP) and a six-coordinate heme cofactor of unknown function.	Pyridoxal Phosphate	86-105	cystathionine beta-synthase	Homo sapiens	29-32
19733148-1	2009	Cystathionine beta-synthase (CBS) is a homocysteine metabolizing enzyme that contains pyridoxal phosphate (PLP) and a six-coordinate heme cofactor of unknown function.	Heme	133-137	cystathionine beta-synthase	Homo sapiens	0-27
19733148-5	2009	The radicals derived from peroxynitrite, nitrogen dioxide and carbonate radical, also inactivated CBS.	carbonate radical	62-79	cystathionine beta-synthase	Homo sapiens	98-101
19733148-1	2009	Cystathionine beta-synthase (CBS) is a homocysteine metabolizing enzyme that contains pyridoxal phosphate (PLP) and a six-coordinate heme cofactor of unknown function.	Heme	133-137	cystathionine beta-synthase	Homo sapiens	29-32
19733148-2	2009	CBS was inactivated by peroxynitrite, the product of nitric oxide and superoxide radicals.	Peroxynitrous Acid	23-36	cystathionine beta-synthase	Homo sapiens	0-3
19733148-7	2009	This study demonstrates the susceptibility of CBS to reactive oxygen/nitrogen species, with potential relevance to hyperhomocysteinemia, a risk factor for cardiovascular diseases.	reactive oxygen/nitrogen species	53-85	cystathionine beta-synthase	Homo sapiens	46-49
19722721-0	2009	Heme regulation of human cystathionine beta-synthase activity: insights from fluorescence and Raman spectroscopy.	Heme	0-4	cystathionine beta-synthase	Homo sapiens	25-52
19631409-5	2009	The H(2)S synthesis in all these cell types was inhibited by the CBS inhibitor hydroxylamine, but not by the CGL inhibitor propargylglycine (PAG).	Hydroxylamine	79-92	cystathionine beta-synthase	Homo sapiens	65-68
19631409-10	2009	These data indicate that H(2)S is an endogenous antiinflammatory and neuroprotective agent under the synthetic control of CBS.	Hydrogen Sulfide	25-30	cystathionine beta-synthase	Homo sapiens	122-125
19715455-4	2009	The in vitro assay used HTMS to quantify the unlabeled product of the CBS reaction, cystathionine.	Cystathionine	84-97	cystathionine beta-synthase	Homo sapiens	70-73
19536086-3	2009	H(2)S production is catalyzed in mammalian cells by cystathionine beta-synthase (CBS) and/or cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	0-5	cystathionine beta-synthase	Homo sapiens	52-79
19531479-6	2009	At equimolar concentrations of CBS and CSE, the simulations predict that H2S production by CBS would account for approximately 25-70% of the total H2S generated via the trans-sulfuration pathway depending on the extent of allosteric activation of CBS by S-adenosylmethionine.	Hydrogen Sulfide	147-150	cystathionine beta-synthase	Homo sapiens	31-34
19531479-6	2009	At equimolar concentrations of CBS and CSE, the simulations predict that H2S production by CBS would account for approximately 25-70% of the total H2S generated via the trans-sulfuration pathway depending on the extent of allosteric activation of CBS by S-adenosylmethionine.	Hydrogen Sulfide	147-150	cystathionine beta-synthase	Homo sapiens	91-94
19657138-2	2009	The main regulating enzymes in folate and homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS).	Folic Acid	31-37	cystathionine beta-synthase	Homo sapiens	118-145
19531479-6	2009	At equimolar concentrations of CBS and CSE, the simulations predict that H2S production by CBS would account for approximately 25-70% of the total H2S generated via the trans-sulfuration pathway depending on the extent of allosteric activation of CBS by S-adenosylmethionine.	Hydrogen Sulfide	147-150	cystathionine beta-synthase	Homo sapiens	91-94
19531479-6	2009	At equimolar concentrations of CBS and CSE, the simulations predict that H2S production by CBS would account for approximately 25-70% of the total H2S generated via the trans-sulfuration pathway depending on the extent of allosteric activation of CBS by S-adenosylmethionine.	S-Adenosylmethionine	254-274	cystathionine beta-synthase	Homo sapiens	31-34
19531479-6	2009	At equimolar concentrations of CBS and CSE, the simulations predict that H2S production by CBS would account for approximately 25-70% of the total H2S generated via the trans-sulfuration pathway depending on the extent of allosteric activation of CBS by S-adenosylmethionine.	S-Adenosylmethionine	254-274	cystathionine beta-synthase	Homo sapiens	91-94
19531479-6	2009	At equimolar concentrations of CBS and CSE, the simulations predict that H2S production by CBS would account for approximately 25-70% of the total H2S generated via the trans-sulfuration pathway depending on the extent of allosteric activation of CBS by S-adenosylmethionine.	S-Adenosylmethionine	254-274	cystathionine beta-synthase	Homo sapiens	91-94
19531479-7	2009	The relative contribution of CBS to H2S genesis is expected to decrease under hyperhomocysteinemic conditions.	Hydrogen Sulfide	36-39	cystathionine beta-synthase	Homo sapiens	29-32
19531479-8	2009	CBS is predicted to be virtually the sole source of lanthionine, and CSE, but not CBS, efficiently cleaves lanthionine.	lanthionine	52-63	cystathionine beta-synthase	Homo sapiens	0-3
19531479-0	2009	Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions.	Hydrogen Sulfide	81-84	cystathionine beta-synthase	Homo sapiens	26-53
19531479-1	2009	In mammals, the two enzymes in the trans-sulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), are believed to be chiefly responsible for hydrogen sulfide (H2S) biogenesis.	Hydrogen Sulfide	176-192	cystathionine beta-synthase	Homo sapiens	62-89
19531479-1	2009	In mammals, the two enzymes in the trans-sulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), are believed to be chiefly responsible for hydrogen sulfide (H2S) biogenesis.	Hydrogen Sulfide	176-192	cystathionine beta-synthase	Homo sapiens	91-94
19531479-1	2009	In mammals, the two enzymes in the trans-sulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), are believed to be chiefly responsible for hydrogen sulfide (H2S) biogenesis.	Hydrogen Sulfide	194-197	cystathionine beta-synthase	Homo sapiens	62-89
19531479-1	2009	In mammals, the two enzymes in the trans-sulfuration pathway, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), are believed to be chiefly responsible for hydrogen sulfide (H2S) biogenesis.	Hydrogen Sulfide	194-197	cystathionine beta-synthase	Homo sapiens	91-94
19531479-3	2009	CBS from both organisms shows a marked preference for H2S generation by beta-replacement of cysteine by homocysteine.	Hydrogen Sulfide	54-57	cystathionine beta-synthase	Homo sapiens	0-3
19531479-3	2009	CBS from both organisms shows a marked preference for H2S generation by beta-replacement of cysteine by homocysteine.	Cysteine	92-100	cystathionine beta-synthase	Homo sapiens	0-3
19531479-3	2009	CBS from both organisms shows a marked preference for H2S generation by beta-replacement of cysteine by homocysteine.	Homocysteine	104-116	cystathionine beta-synthase	Homo sapiens	0-3
19531479-6	2009	At equimolar concentrations of CBS and CSE, the simulations predict that H2S production by CBS would account for approximately 25-70% of the total H2S generated via the trans-sulfuration pathway depending on the extent of allosteric activation of CBS by S-adenosylmethionine.	Hydrogen Sulfide	73-76	cystathionine beta-synthase	Homo sapiens	31-34
19531479-6	2009	At equimolar concentrations of CBS and CSE, the simulations predict that H2S production by CBS would account for approximately 25-70% of the total H2S generated via the trans-sulfuration pathway depending on the extent of allosteric activation of CBS by S-adenosylmethionine.	Hydrogen Sulfide	73-76	cystathionine beta-synthase	Homo sapiens	91-94
19531479-6	2009	At equimolar concentrations of CBS and CSE, the simulations predict that H2S production by CBS would account for approximately 25-70% of the total H2S generated via the trans-sulfuration pathway depending on the extent of allosteric activation of CBS by S-adenosylmethionine.	Hydrogen Sulfide	73-76	cystathionine beta-synthase	Homo sapiens	91-94
19657138-2	2009	The main regulating enzymes in folate and homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS).	Folic Acid	31-37	cystathionine beta-synthase	Homo sapiens	147-150
19439522-0	2009	Ischemia-reperfusion reduces cystathionine-beta-synthase-mediated hydrogen sulfide generation in the kidney.	Hydrogen Sulfide	66-82	cystathionine beta-synthase	Homo sapiens	29-56
19285949-3	2009	H(2)S is a gas that can be formed by the action of two enzymes, cystathionine gamma-lyase and cystathionine beta-synthase, both involved in the metabolism of cysteine.	Hydrogen Sulfide	0-5	cystathionine beta-synthase	Homo sapiens	94-121
19285949-3	2009	H(2)S is a gas that can be formed by the action of two enzymes, cystathionine gamma-lyase and cystathionine beta-synthase, both involved in the metabolism of cysteine.	Cysteine	158-166	cystathionine beta-synthase	Homo sapiens	94-121
19439522-7	2009	The CBS-mediated H(2)S production was decreased, leading to a significant reduction in the renal H(2)S level.	Hydrogen Sulfide	17-22	cystathionine beta-synthase	Homo sapiens	4-7
19439522-1	2009	Cystathionine-beta-synthase (CBS) catalyzes the rate-limiting step in the transsulfuration pathway for the metabolism of homocysteine (Hcy) in the kidney.	Homocysteine	121-133	cystathionine beta-synthase	Homo sapiens	0-27
19439522-7	2009	The CBS-mediated H(2)S production was decreased, leading to a significant reduction in the renal H(2)S level.	Hydrogen Sulfide	97-102	cystathionine beta-synthase	Homo sapiens	4-7
19439522-1	2009	Cystathionine-beta-synthase (CBS) catalyzes the rate-limiting step in the transsulfuration pathway for the metabolism of homocysteine (Hcy) in the kidney.	Homocysteine	121-133	cystathionine beta-synthase	Homo sapiens	29-32
19439522-9	2009	Partial restoration of CBS activity by intraperitoneal injection of the nitric oxide scavenger, 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide not only increased renal H(2)S levels but also alleviated ischemia-reperfusion-induced lipid peroxidation and reduced cell damage in the kidney tissue.	Nitric Oxide	72-84	cystathionine beta-synthase	Homo sapiens	23-26
19439522-1	2009	Cystathionine-beta-synthase (CBS) catalyzes the rate-limiting step in the transsulfuration pathway for the metabolism of homocysteine (Hcy) in the kidney.	Homocysteine	135-138	cystathionine beta-synthase	Homo sapiens	0-27
19439522-1	2009	Cystathionine-beta-synthase (CBS) catalyzes the rate-limiting step in the transsulfuration pathway for the metabolism of homocysteine (Hcy) in the kidney.	Homocysteine	135-138	cystathionine beta-synthase	Homo sapiens	29-32
19439522-9	2009	Partial restoration of CBS activity by intraperitoneal injection of the nitric oxide scavenger, 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide not only increased renal H(2)S levels but also alleviated ischemia-reperfusion-induced lipid peroxidation and reduced cell damage in the kidney tissue.	2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide	96-150	cystathionine beta-synthase	Homo sapiens	23-26
19439522-2	2009	Our recent study demonstrates that ischemia-reperfusion reduces the activity of CBS leading to Hcy accumulation in the kidney, which in turn contributes to renal injury.	Homocysteine	95-98	cystathionine beta-synthase	Homo sapiens	80-83
19439522-9	2009	Partial restoration of CBS activity by intraperitoneal injection of the nitric oxide scavenger, 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide not only increased renal H(2)S levels but also alleviated ischemia-reperfusion-induced lipid peroxidation and reduced cell damage in the kidney tissue.	Hydrogen Sulfide	176-181	cystathionine beta-synthase	Homo sapiens	23-26
19439522-3	2009	CBS is also capable of catalyzing the reaction of cysteine with Hcy to produce hydrogen sulfide (H(2)S), a gaseous molecule that plays an important role in many physiological and pathological processes.	Cysteine	50-58	cystathionine beta-synthase	Homo sapiens	0-3
19439522-3	2009	CBS is also capable of catalyzing the reaction of cysteine with Hcy to produce hydrogen sulfide (H(2)S), a gaseous molecule that plays an important role in many physiological and pathological processes.	Homocysteine	64-67	cystathionine beta-synthase	Homo sapiens	0-3
19439522-3	2009	CBS is also capable of catalyzing the reaction of cysteine with Hcy to produce hydrogen sulfide (H(2)S), a gaseous molecule that plays an important role in many physiological and pathological processes.	Hydrogen Sulfide	79-95	cystathionine beta-synthase	Homo sapiens	0-3
19439522-3	2009	CBS is also capable of catalyzing the reaction of cysteine with Hcy to produce hydrogen sulfide (H(2)S), a gaseous molecule that plays an important role in many physiological and pathological processes.	Hydrogen Sulfide	97-102	cystathionine beta-synthase	Homo sapiens	0-3
19439522-4	2009	The aim of the present study was to examine the effect of ischemia-reperfusion on CBS-mediated H(2)S production in the kidney and to determine whether changes in the endogenous H(2)S generation had any impact on renal ischemia-reperfusion injury.	Hydrogen Sulfide	95-100	cystathionine beta-synthase	Homo sapiens	82-85
19424622-1	2009	The cystathionine beta-synthase (CBS) gene encodes an enzyme that catalyzes the synthesis of cystathionine in the trans-sulfuration pathway and is subject to tight regulation because of its critical role in antioxidant and methylation metabolism.	Cystathionine	4-17	cystathionine beta-synthase	Homo sapiens	33-36
19448746-4	2009	Residues E136, H138, Y248, and D249 of ytCBS were also targeted as they correspond to identical polar residues lining the mouth of the active site in the structure of human CBS.	e136	9-13	cystathionine beta-synthase	Homo sapiens	41-44
19448746-4	2009	Residues E136, H138, Y248, and D249 of ytCBS were also targeted as they correspond to identical polar residues lining the mouth of the active site in the structure of human CBS.	h138	15-19	cystathionine beta-synthase	Homo sapiens	41-44
19448746-4	2009	Residues E136, H138, Y248, and D249 of ytCBS were also targeted as they correspond to identical polar residues lining the mouth of the active site in the structure of human CBS.	y248	21-25	cystathionine beta-synthase	Homo sapiens	41-44
19448746-4	2009	Residues E136, H138, Y248, and D249 of ytCBS were also targeted as they correspond to identical polar residues lining the mouth of the active site in the structure of human CBS.	d249	31-35	cystathionine beta-synthase	Homo sapiens	41-44
19329426-6	2009	Furthermore, by replacing the anionic C-terminal tail residues that extend the CBS module with histidines, the transport of OpuA became pH-dependent, presumably by additional charge interactions of the histidine residues with the membrane.	Histidine	95-105	cystathionine beta-synthase	Homo sapiens	79-82
19296828-1	2009	Genome mining and biochemical analyses have shown that Leishmania major possesses two pathways for cysteine synthesis--the de novo biosynthesis pathway comprising SAT (serine acetyltransferase) and CS (cysteine synthase) and the RTS (reverse trans-sulfuration) pathway comprising CBS (cystathionine beta-synthase) and CGL (cystathionine gamma-lyase).	Cysteine	99-107	cystathionine beta-synthase	Homo sapiens	280-283
19296828-5	2009	LmjCBS (L. major CBS) catalyses the synthesis of cystathionine from homocysteine, but, unlike mammalian CBS, also has high cysteine synthase activity (but with the Km for sulfide being 10.7 mM).	lmjcbs	0-6	cystathionine beta-synthase	Homo sapiens	17-20
19296828-5	2009	LmjCBS (L. major CBS) catalyses the synthesis of cystathionine from homocysteine, but, unlike mammalian CBS, also has high cysteine synthase activity (but with the Km for sulfide being 10.7 mM).	Cystathionine	49-62	cystathionine beta-synthase	Homo sapiens	3-6
19296828-5	2009	LmjCBS (L. major CBS) catalyses the synthesis of cystathionine from homocysteine, but, unlike mammalian CBS, also has high cysteine synthase activity (but with the Km for sulfide being 10.7 mM).	Cystathionine	49-62	cystathionine beta-synthase	Homo sapiens	17-20
19296828-5	2009	LmjCBS (L. major CBS) catalyses the synthesis of cystathionine from homocysteine, but, unlike mammalian CBS, also has high cysteine synthase activity (but with the Km for sulfide being 10.7 mM).	Homocysteine	68-80	cystathionine beta-synthase	Homo sapiens	3-6
19296828-5	2009	LmjCBS (L. major CBS) catalyses the synthesis of cystathionine from homocysteine, but, unlike mammalian CBS, also has high cysteine synthase activity (but with the Km for sulfide being 10.7 mM).	Homocysteine	68-80	cystathionine beta-synthase	Homo sapiens	17-20
19329426-6	2009	Furthermore, by replacing the anionic C-terminal tail residues that extend the CBS module with histidines, the transport of OpuA became pH-dependent, presumably by additional charge interactions of the histidine residues with the membrane.	opua	124-128	cystathionine beta-synthase	Homo sapiens	79-82
19296828-5	2009	LmjCBS (L. major CBS) catalyses the synthesis of cystathionine from homocysteine, but, unlike mammalian CBS, also has high cysteine synthase activity (but with the Km for sulfide being 10.7 mM).	Sulfides	171-178	cystathionine beta-synthase	Homo sapiens	3-6
19296828-5	2009	LmjCBS (L. major CBS) catalyses the synthesis of cystathionine from homocysteine, but, unlike mammalian CBS, also has high cysteine synthase activity (but with the Km for sulfide being 10.7 mM).	Sulfides	171-178	cystathionine beta-synthase	Homo sapiens	17-20
19329426-6	2009	Furthermore, by replacing the anionic C-terminal tail residues that extend the CBS module with histidines, the transport of OpuA became pH-dependent, presumably by additional charge interactions of the histidine residues with the membrane.	Histidine	95-104	cystathionine beta-synthase	Homo sapiens	79-82
19329426-8	2009	Altogether the analyses of the CBS mutants support the notion that the osmotic regulation of OpuA involves a simple biophysical switching mechanism, in which nonspecific electrostatic interactions of a protein module with the membrane are sufficient to lock the transporter in the inactive state.	opua	93-97	cystathionine beta-synthase	Homo sapiens	31-34
19010420-1	2009	Cystathionine beta-synthase (CBS) catalyzes the pyridoxal-50-phosphate-dependent condensation of L-serine and L-homocysteine to form L-cystathionine in the first step of the transsulfuration pathway.	pyridoxal-50-phosphate	48-70	cystathionine beta-synthase	Homo sapiens	0-27
19232736-0	2009	Modulation of the heme electronic structure and cystathionine beta-synthase activity by second coordination sphere ligands: The role of heme ligand switching in redox regulation.	Heme	136-140	cystathionine beta-synthase	Homo sapiens	48-75
19261609-2	2009	It is widely assumed that desulfhydration of cysteine is the major source of H(2)S in mammals and is catalyzed by the transsulfuration pathway enzymes, cystathionine beta-synthase and cystathionine gamma-lyase (CSE).	Cysteine	45-53	cystathionine beta-synthase	Homo sapiens	152-179
19261609-2	2009	It is widely assumed that desulfhydration of cysteine is the major source of H(2)S in mammals and is catalyzed by the transsulfuration pathway enzymes, cystathionine beta-synthase and cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	77-82	cystathionine beta-synthase	Homo sapiens	152-179
19426680-5	2009	The dramatic loss of FPGS activity in 7-hydroxymethotrexate-resistant cells was associated with alterations in the expression of various genes aimed at preserving reduced folates and/or enhancing purine nucleotide biosynthesis, e.g. methylene tetrahydrofolate reductase, glycinamide ribonucleotide formyltransferase, adenosine deaminase, cystathionine beta synthase, as well as the ATP-dependent folate exporters BCRP/ABCG2 and MRP1/ABCC1.	7-hydroxymethotrexate	38-59	cystathionine beta-synthase	Homo sapiens	338-365
19232736-1	2009	In humans, cystathionine beta-synthase (CBS) is a hemeprotein, which catalyzes a pyridoxal phosphate (PLP)-dependent condensation reaction.	Pyridoxal Phosphate	81-100	cystathionine beta-synthase	Homo sapiens	11-38
19232736-1	2009	In humans, cystathionine beta-synthase (CBS) is a hemeprotein, which catalyzes a pyridoxal phosphate (PLP)-dependent condensation reaction.	Pyridoxal Phosphate	81-100	cystathionine beta-synthase	Homo sapiens	40-43
19232736-6	2009	The electrostatic interaction between C52 and R266 is critical for stabilizing the ferrous heme and its disruption leads to the facile formation of a 424nm (C-424) absorbing ferrous species, which is inactive, compared to the active 449nm ferrous species for wild-type CBS.	cryptophycin 52	38-41	cystathionine beta-synthase	Homo sapiens	269-272
19232736-6	2009	The electrostatic interaction between C52 and R266 is critical for stabilizing the ferrous heme and its disruption leads to the facile formation of a 424nm (C-424) absorbing ferrous species, which is inactive, compared to the active 449nm ferrous species for wild-type CBS.	Mordant Yellow 10	46-50	cystathionine beta-synthase	Homo sapiens	269-272
19232736-6	2009	The electrostatic interaction between C52 and R266 is critical for stabilizing the ferrous heme and its disruption leads to the facile formation of a 424nm (C-424) absorbing ferrous species, which is inactive, compared to the active 449nm ferrous species for wild-type CBS.	ferrous heme	83-95	cystathionine beta-synthase	Homo sapiens	269-272
19232736-6	2009	The electrostatic interaction between C52 and R266 is critical for stabilizing the ferrous heme and its disruption leads to the facile formation of a 424nm (C-424) absorbing ferrous species, which is inactive, compared to the active 449nm ferrous species for wild-type CBS.	Carbon	38-39	cystathionine beta-synthase	Homo sapiens	269-272
19232736-8	2009	EXAFS studies on C-424 CBS are consistent with the presence of two axial N/O low Z scatters with only one being a rigid unit of a histidine residue while the other could be a solvent molecule, an oxygen atom from the peptide backbone or a side chain nitrogen.	Carbon	17-18	cystathionine beta-synthase	Homo sapiens	23-26
19232736-8	2009	EXAFS studies on C-424 CBS are consistent with the presence of two axial N/O low Z scatters with only one being a rigid unit of a histidine residue while the other could be a solvent molecule, an oxygen atom from the peptide backbone or a side chain nitrogen.	Histidine	130-139	cystathionine beta-synthase	Homo sapiens	23-26
19232736-8	2009	EXAFS studies on C-424 CBS are consistent with the presence of two axial N/O low Z scatters with only one being a rigid unit of a histidine residue while the other could be a solvent molecule, an oxygen atom from the peptide backbone or a side chain nitrogen.	Oxygen	196-202	cystathionine beta-synthase	Homo sapiens	23-26
19232736-9	2009	The redox potential for the heme in full-length CBS is -350+/-4mV and is substantially lower than the value of -287+/-2mV determined for truncated CBS.	Heme	28-32	cystathionine beta-synthase	Homo sapiens	48-51
19232736-9	2009	The redox potential for the heme in full-length CBS is -350+/-4mV and is substantially lower than the value of -287+/-2mV determined for truncated CBS.	Heme	28-32	cystathionine beta-synthase	Homo sapiens	147-150
19010420-1	2009	Cystathionine beta-synthase (CBS) catalyzes the pyridoxal-50-phosphate-dependent condensation of L-serine and L-homocysteine to form L-cystathionine in the first step of the transsulfuration pathway.	pyridoxal-50-phosphate	48-70	cystathionine beta-synthase	Homo sapiens	29-32
19010420-1	2009	Cystathionine beta-synthase (CBS) catalyzes the pyridoxal-50-phosphate-dependent condensation of L-serine and L-homocysteine to form L-cystathionine in the first step of the transsulfuration pathway.	Serine	97-105	cystathionine beta-synthase	Homo sapiens	0-27
19010420-1	2009	Cystathionine beta-synthase (CBS) catalyzes the pyridoxal-50-phosphate-dependent condensation of L-serine and L-homocysteine to form L-cystathionine in the first step of the transsulfuration pathway.	Serine	97-105	cystathionine beta-synthase	Homo sapiens	29-32
19010420-1	2009	Cystathionine beta-synthase (CBS) catalyzes the pyridoxal-50-phosphate-dependent condensation of L-serine and L-homocysteine to form L-cystathionine in the first step of the transsulfuration pathway.	Homocysteine	110-124	cystathionine beta-synthase	Homo sapiens	0-27
19010420-1	2009	Cystathionine beta-synthase (CBS) catalyzes the pyridoxal-50-phosphate-dependent condensation of L-serine and L-homocysteine to form L-cystathionine in the first step of the transsulfuration pathway.	Homocysteine	110-124	cystathionine beta-synthase	Homo sapiens	29-32
19010420-1	2009	Cystathionine beta-synthase (CBS) catalyzes the pyridoxal-50-phosphate-dependent condensation of L-serine and L-homocysteine to form L-cystathionine in the first step of the transsulfuration pathway.	Cystathionine	133-148	cystathionine beta-synthase	Homo sapiens	0-27
19010420-1	2009	Cystathionine beta-synthase (CBS) catalyzes the pyridoxal-50-phosphate-dependent condensation of L-serine and L-homocysteine to form L-cystathionine in the first step of the transsulfuration pathway.	Cystathionine	133-148	cystathionine beta-synthase	Homo sapiens	29-32
19010420-3	2009	Therefore, a series of five expression constructs, each incorporating a 6-His tag, were developed to enable the efficient purification of hCBS via immobilized metal ion affinity chromatography.	Metals	159-164	cystathionine beta-synthase	Homo sapiens	138-142
19010420-5	2009	The addition of an amino-terminal, 6-His tag, in the absence of a protein fusion partner and in the absence or presence ofa protease-cleavable linker, was found to be sufficient for the purification of soluble hCBS and resulted in enzyme with 86-91% heme saturation and with activity similar to that reported for other hCBS expression constructs.	6-his	35-40	cystathionine beta-synthase	Homo sapiens	210-214
19010420-5	2009	The addition of an amino-terminal, 6-His tag, in the absence of a protein fusion partner and in the absence or presence ofa protease-cleavable linker, was found to be sufficient for the purification of soluble hCBS and resulted in enzyme with 86-91% heme saturation and with activity similar to that reported for other hCBS expression constructs.	Heme	250-254	cystathionine beta-synthase	Homo sapiens	210-214
19010420-6	2009	The continuous assay for L-Cth production, employing cystathionine beta-lyase and L-lactate dehydrogenase as coupling enzymes, was employed here for the first time to determine the steady-state kinetic parameters of hCBS, via global analysis, and revealed previously unreported substrate inhibition by L-Hcys (K(i)(L-HCYS) = 2.1 +/- 0.2 mM).	l-hcys	302-308	cystathionine beta-synthase	Homo sapiens	216-220
19010420-6	2009	The continuous assay for L-Cth production, employing cystathionine beta-lyase and L-lactate dehydrogenase as coupling enzymes, was employed here for the first time to determine the steady-state kinetic parameters of hCBS, via global analysis, and revealed previously unreported substrate inhibition by L-Hcys (K(i)(L-HCYS) = 2.1 +/- 0.2 mM).	l-hcys	315-321	cystathionine beta-synthase	Homo sapiens	216-220
19010420-7	2009	The kinetic parameters for the hCBS-catalyzed hydrolysis of L-Cth toL-Ser and L-Hcys were also determined and the k(cat)/K(m)(L-CTH) of this reaction is only approximately 2-fold lower than the k(cat)/K(m)(L-SER) of the physiological, condensation reaction.	Serine	70-73	cystathionine beta-synthase	Homo sapiens	31-35
19010420-7	2009	The kinetic parameters for the hCBS-catalyzed hydrolysis of L-Cth toL-Ser and L-Hcys were also determined and the k(cat)/K(m)(L-CTH) of this reaction is only approximately 2-fold lower than the k(cat)/K(m)(L-SER) of the physiological, condensation reaction.	l-hcys	78-84	cystathionine beta-synthase	Homo sapiens	31-35
19010420-7	2009	The kinetic parameters for the hCBS-catalyzed hydrolysis of L-Cth toL-Ser and L-Hcys were also determined and the k(cat)/K(m)(L-CTH) of this reaction is only approximately 2-fold lower than the k(cat)/K(m)(L-SER) of the physiological, condensation reaction.	l	60-61	cystathionine beta-synthase	Homo sapiens	31-35
19010420-7	2009	The kinetic parameters for the hCBS-catalyzed hydrolysis of L-Cth toL-Ser and L-Hcys were also determined and the k(cat)/K(m)(L-CTH) of this reaction is only approximately 2-fold lower than the k(cat)/K(m)(L-SER) of the physiological, condensation reaction.	Serine	208-211	cystathionine beta-synthase	Homo sapiens	31-35
18987302-1	2009	Untreated cystathionine beta-synthase (CBS) deficiency in humans is characterized by extremely elevated plasma total homocysteine (tHcy&gt;200 microM), with thrombosis as the major cause of morbidity.	Homocysteine	117-129	cystathionine beta-synthase	Homo sapiens	10-37
19255435-1	2009	Hydrogen sulfide (H(2)S) is synthesized by 2 enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	54-81
19255435-1	2009	Hydrogen sulfide (H(2)S) is synthesized by 2 enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE).	Hydrogen Sulfide	18-23	cystathionine beta-synthase	Homo sapiens	54-81
18987302-1	2009	Untreated cystathionine beta-synthase (CBS) deficiency in humans is characterized by extremely elevated plasma total homocysteine (tHcy&gt;200 microM), with thrombosis as the major cause of morbidity.	thcy	131-135	cystathionine beta-synthase	Homo sapiens	10-37
19374684-1	2009	Hydrogen sulfide (H(2)S) is a well known and pungent toxic gas that has recently been shown to be synthesised in man from the amino acids cystathionine, homocysteine and cysteine by at least two distinct enzymes; cystathionine-gamma-lyase and cystathionine-beta-synthase.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	243-270
19019829-2	2009	Cystathionine beta-synthase and cystathionine gamma-lyase (CSE) are two pyridoxal-5"-phosphate (PLP)-dependent enzymes largely responsible for the production of H(2)S in mammals.	Pyridoxal Phosphate	72-94	cystathionine beta-synthase	Homo sapiens	0-27
19374684-1	2009	Hydrogen sulfide (H(2)S) is a well known and pungent toxic gas that has recently been shown to be synthesised in man from the amino acids cystathionine, homocysteine and cysteine by at least two distinct enzymes; cystathionine-gamma-lyase and cystathionine-beta-synthase.	Hydrogen Sulfide	18-23	cystathionine beta-synthase	Homo sapiens	243-270
19374684-1	2009	Hydrogen sulfide (H(2)S) is a well known and pungent toxic gas that has recently been shown to be synthesised in man from the amino acids cystathionine, homocysteine and cysteine by at least two distinct enzymes; cystathionine-gamma-lyase and cystathionine-beta-synthase.	Cystathionine	138-151	cystathionine beta-synthase	Homo sapiens	243-270
18629636-5	2009	The inhibitory action of H2S donors on NE release was attenuated by aminooxyacetic acid (AOA) and propargyglycine (PAG), inhibitors of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), respectively.	Hydrogen Sulfide	25-28	cystathionine beta-synthase	Homo sapiens	135-162
18629636-5	2009	The inhibitory action of H2S donors on NE release was attenuated by aminooxyacetic acid (AOA) and propargyglycine (PAG), inhibitors of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), respectively.	Hydrogen Sulfide	25-28	cystathionine beta-synthase	Homo sapiens	164-167
18629636-5	2009	The inhibitory action of H2S donors on NE release was attenuated by aminooxyacetic acid (AOA) and propargyglycine (PAG), inhibitors of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), respectively.	Aminooxyacetic Acid	68-87	cystathionine beta-synthase	Homo sapiens	135-162
18629636-5	2009	The inhibitory action of H2S donors on NE release was attenuated by aminooxyacetic acid (AOA) and propargyglycine (PAG), inhibitors of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), respectively.	Aminooxyacetic Acid	89-92	cystathionine beta-synthase	Homo sapiens	164-167
18629636-5	2009	The inhibitory action of H2S donors on NE release was attenuated by aminooxyacetic acid (AOA) and propargyglycine (PAG), inhibitors of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), respectively.	propargyglycine	98-113	cystathionine beta-synthase	Homo sapiens	164-167
19019829-2	2009	Cystathionine beta-synthase and cystathionine gamma-lyase (CSE) are two pyridoxal-5"-phosphate (PLP)-dependent enzymes largely responsible for the production of H(2)S in mammals.	Hydrogen Sulfide	161-166	cystathionine beta-synthase	Homo sapiens	0-27
18849566-0	2008	Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone.	Heme	55-59	cystathionine beta-synthase	Homo sapiens	7-34
18849566-0	2008	Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone.	metal-substituted porphyrins	92-120	cystathionine beta-synthase	Homo sapiens	7-34
18849566-1	2008	Cystathionine beta-synthase (CBS), a key enzyme in the metabolism of homocysteine, has previously been shown to require a heme co-factor for maximal activity.	Homocysteine	69-81	cystathionine beta-synthase	Homo sapiens	0-27
18849566-1	2008	Cystathionine beta-synthase (CBS), a key enzyme in the metabolism of homocysteine, has previously been shown to require a heme co-factor for maximal activity.	Homocysteine	69-81	cystathionine beta-synthase	Homo sapiens	29-32
18849566-2	2008	However, the biochemical function of the CBS heme is not well defined.	Heme	45-49	cystathionine beta-synthase	Homo sapiens	41-44
18849566-4	2008	Addition of exogenous heme, porphyrins with non-iron metal, or porphyrin lacking metal entirely produced stable and active CBS enzyme.	Heme	22-26	cystathionine beta-synthase	Homo sapiens	123-126
18849566-4	2008	Addition of exogenous heme, porphyrins with non-iron metal, or porphyrin lacking metal entirely produced stable and active CBS enzyme.	Porphyrins	28-38	cystathionine beta-synthase	Homo sapiens	123-126
18849566-4	2008	Addition of exogenous heme, porphyrins with non-iron metal, or porphyrin lacking metal entirely produced stable and active CBS enzyme.	Iron	48-52	cystathionine beta-synthase	Homo sapiens	123-126
18849566-4	2008	Addition of exogenous heme, porphyrins with non-iron metal, or porphyrin lacking metal entirely produced stable and active CBS enzyme.	Metals	53-58	cystathionine beta-synthase	Homo sapiens	123-126
18849566-4	2008	Addition of exogenous heme, porphyrins with non-iron metal, or porphyrin lacking metal entirely produced stable and active CBS enzyme.	Porphyrins	28-37	cystathionine beta-synthase	Homo sapiens	123-126
18849566-4	2008	Addition of exogenous heme, porphyrins with non-iron metal, or porphyrin lacking metal entirely produced stable and active CBS enzyme.	Metals	81-86	cystathionine beta-synthase	Homo sapiens	123-126
18849566-5	2008	Purification of recombinant CBS enzyme expressed in the presence of various metalloporphyrins confirmed that Mn(III) and Co(III) had 30-60% of the specific activity of Fe(III)-CBS, and still responded to allosteric activation by S-adenosyl-L-methionine.	Metalloporphyrins	76-93	cystathionine beta-synthase	Homo sapiens	28-31
18849566-5	2008	Purification of recombinant CBS enzyme expressed in the presence of various metalloporphyrins confirmed that Mn(III) and Co(III) had 30-60% of the specific activity of Fe(III)-CBS, and still responded to allosteric activation by S-adenosyl-L-methionine.	S-Adenosylmethionine	229-252	cystathionine beta-synthase	Homo sapiens	28-31
18849566-6	2008	Treatment of S. cerevisiae with the chemical chaperone trimethylamine-N-oxide resulted in near complete restoration of function to human CBS produced in a heme-deficient strain.	trimethyloxamine	55-77	cystathionine beta-synthase	Homo sapiens	137-140
18849566-7	2008	Taken together, these results suggest that porphyrin moiety of the heme plays a critical role in proper CBS folding and assembly, but that the metal ion is not essential for this function or for allosteric regulation by S-adenosyl-L-methionine.	Porphyrins	43-52	cystathionine beta-synthase	Homo sapiens	104-107
18849566-7	2008	Taken together, these results suggest that porphyrin moiety of the heme plays a critical role in proper CBS folding and assembly, but that the metal ion is not essential for this function or for allosteric regulation by S-adenosyl-L-methionine.	Heme	67-71	cystathionine beta-synthase	Homo sapiens	104-107
18708589-2	2008	In addition to elevating plasma Hcy, mutations in cystathionine beta-synthase (CBS) or methylenetetrahydrofolate reductase (MTHFR) gene lead to markedly elevated levels of circulating Hcy-thiolactone.	Homocysteine	32-35	cystathionine beta-synthase	Homo sapiens	79-82
18940190-8	2008	An activator of cystathionine beta-synthase, SAM (100 microM), enhanced relaxations elicited by low concentrations of NaHS but attenuated responses caused by the higher concentrations of this H(2)S donor.	sodium bisulfide	118-122	cystathionine beta-synthase	Homo sapiens	16-43
18940190-10	2008	We conclude that the observed inhibitory action of NaHS and Na(2)S in isolated porcine irides is dependent on endogenous production of prostanoids and the biosynthesis of H(2)S by cystathionine gamma-lyase and cystathionine beta-synthase.	sodium bisulfide	51-55	cystathionine beta-synthase	Homo sapiens	210-237
18940190-10	2008	We conclude that the observed inhibitory action of NaHS and Na(2)S in isolated porcine irides is dependent on endogenous production of prostanoids and the biosynthesis of H(2)S by cystathionine gamma-lyase and cystathionine beta-synthase.	sodium sulfide	60-66	cystathionine beta-synthase	Homo sapiens	210-237
18974309-9	2008	By means of RT-PCR, Western blot analysis, and immunohistochemistry, we observed the expression of both H(2)S synthesizing enzymes (CSE and cystathionine-beta-synthase) in aorta, vena cava, hepatic artery, and portal vein, as well as in hepatic parenchymal tissue.	Hydrogen Sulfide	104-109	cystathionine beta-synthase	Homo sapiens	140-167
18940190-10	2008	We conclude that the observed inhibitory action of NaHS and Na(2)S in isolated porcine irides is dependent on endogenous production of prostanoids and the biosynthesis of H(2)S by cystathionine gamma-lyase and cystathionine beta-synthase.	Hydrogen Sulfide	171-176	cystathionine beta-synthase	Homo sapiens	210-237
18708589-2	2008	In addition to elevating plasma Hcy, mutations in cystathionine beta-synthase (CBS) or methylenetetrahydrofolate reductase (MTHFR) gene lead to markedly elevated levels of circulating Hcy-thiolactone.	homocysteine thiolactone	184-199	cystathionine beta-synthase	Homo sapiens	50-77
18708589-2	2008	In addition to elevating plasma Hcy, mutations in cystathionine beta-synthase (CBS) or methylenetetrahydrofolate reductase (MTHFR) gene lead to markedly elevated levels of circulating Hcy-thiolactone.	homocysteine thiolactone	184-199	cystathionine beta-synthase	Homo sapiens	79-82
18708589-5	2008	Here we show that plasma N-Hcy-protein levels are significantly elevated in CBS- and MTHFR-deficient patients.	Nitrogen	25-26	cystathionine beta-synthase	Homo sapiens	76-79
26620179-2	2008	The energies of dimers with the strongest interactions were further studied at the CCSD(T)/CBS level of theory, which suggests that the T-shaped interactions in adenine dimers are very strong (up to -35 kJ mol(-1)).	Adenine	161-168	cystathionine beta-synthase	Homo sapiens	91-94
18792976-1	2008	Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR) and cystathionine beta-synthase (CBS) genes, involved in the intracellular metabolism of homocysteine (Hcy), can result in hyperhomocysteinemia.	Homocysteine	192-204	cystathionine beta-synthase	Homo sapiens	107-134
18792976-1	2008	Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR) and cystathionine beta-synthase (CBS) genes, involved in the intracellular metabolism of homocysteine (Hcy), can result in hyperhomocysteinemia.	Homocysteine	192-204	cystathionine beta-synthase	Homo sapiens	136-139
18792976-1	2008	Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR) and cystathionine beta-synthase (CBS) genes, involved in the intracellular metabolism of homocysteine (Hcy), can result in hyperhomocysteinemia.	Homocysteine	206-209	cystathionine beta-synthase	Homo sapiens	107-134
18792976-1	2008	Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR) and cystathionine beta-synthase (CBS) genes, involved in the intracellular metabolism of homocysteine (Hcy), can result in hyperhomocysteinemia.	Homocysteine	206-209	cystathionine beta-synthase	Homo sapiens	136-139
18792976-4	2008	The T833C CBS mutation was identified in association with 844ins68 in all the carriers of the insertion.	844ins68	58-66	cystathionine beta-synthase	Homo sapiens	10-13
19261978-8	2008	For example, plasma Hcy-thiolactone was found to be elevated 59-72-fold in human patients with hyperhomocysteinemia secondary to mutations in methylenetetrahydrofolate reductase (MTHFR) or cystathionine beta-synthase (CBS) genes.	homocysteine thiolactone	20-35	cystathionine beta-synthase	Homo sapiens	189-216
19261978-8	2008	For example, plasma Hcy-thiolactone was found to be elevated 59-72-fold in human patients with hyperhomocysteinemia secondary to mutations in methylenetetrahydrofolate reductase (MTHFR) or cystathionine beta-synthase (CBS) genes.	homocysteine thiolactone	20-35	cystathionine beta-synthase	Homo sapiens	218-221
26620179-4	2008	Most importantly, this study is the first to compare the stacking and T-shaped interactions between all aromatic amino acids and select (natural and damaged) DNA nucleobases where the differences between stacking and T-shaped interactions at the CCSD(T)/CBS level are small.	Amino Acids, Aromatic	104-124	cystathionine beta-synthase	Homo sapiens	254-257
18776696-0	2008	Modulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutations.	Arginine	58-61	cystathionine beta-synthase	Homo sapiens	14-41
18937169-5	2008	Hydrogen sulfide is formed endogenously in the human body by enzymes such as cystathionine beta-synthase (CBS) in the brain and cystathionine gamma-lyase (CSE) in liver, vascular and non-vascular smooth muscle.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	77-104
18776696-0	2008	Modulation of cystathionine beta-synthase activity by the Arg-51 and Arg-224 mutations.	Arginine	69-72	cystathionine beta-synthase	Homo sapiens	14-41
18776696-1	2008	Human cystathionine beta-synthase (CBS) catalyzes a pyridoxal 5"-phosphate (PLP) dependent beta-replacement reaction to synthesize cystathionine from serine and homocysteine.	Serine	150-156	cystathionine beta-synthase	Homo sapiens	6-33
18776696-1	2008	Human cystathionine beta-synthase (CBS) catalyzes a pyridoxal 5"-phosphate (PLP) dependent beta-replacement reaction to synthesize cystathionine from serine and homocysteine.	Homocysteine	161-173	cystathionine beta-synthase	Homo sapiens	6-33
18398434-2	2008	The effect of the cystathionine beta-synthase (CBS) 844ins68 polymorphism on homocysteine and folate concentrations was examined alone and in the context of the 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C&gt;T polymorphism in a Northwestern European male population.	Homocysteine	77-89	cystathionine beta-synthase	Homo sapiens	18-45
18398434-2	2008	The effect of the cystathionine beta-synthase (CBS) 844ins68 polymorphism on homocysteine and folate concentrations was examined alone and in the context of the 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C&gt;T polymorphism in a Northwestern European male population.	Folic Acid	94-100	cystathionine beta-synthase	Homo sapiens	18-45
18060852-3	2008	In addition, our construct has the added benefit of yielding a purified CBS which only contains one extra glycine amino acid residue at the N-terminus.	Glycine	106-124	cystathionine beta-synthase	Homo sapiens	72-75
18487201-6	2008	Expression of cystathionine beta-synthase, a key gene in the transsulfuration pathway, and various glutathione production genes were increased, resulting in a 5-fold increase in glutathione.	Glutathione	178-189	cystathionine beta-synthase	Homo sapiens	14-41
18203168-8	2008	We found a reduced risk of CL/P with mothers who carried the CBS C699T variant (rs234706); relative risk was 0.94 with one copy of the T allele (95% CI 0.63-1.4) and 0.50 (95% CI 0.26-0.96) with two copies (P = 0.008).	Phosphorus	30-31	cystathionine beta-synthase	Homo sapiens	61-64
18565815-16	2008	CONCLUSION: The lower homocysteine, folic acid and B 12 values may be considered as the consequence of an increased cystathionine-beta-synthase activity ("atheroma free model").	Homocysteine	22-34	cystathionine beta-synthase	Homo sapiens	116-143
18565815-16	2008	CONCLUSION: The lower homocysteine, folic acid and B 12 values may be considered as the consequence of an increased cystathionine-beta-synthase activity ("atheroma free model").	Folic Acid	36-46	cystathionine beta-synthase	Homo sapiens	116-143
18060852-8	2008	Furthermore, we have shown unequivocally that CBS binds one mole of heme per subunit by determining both the heme and the iron content of the enzyme.	Heme	68-72	cystathionine beta-synthase	Homo sapiens	46-49
18060852-8	2008	Furthermore, we have shown unequivocally that CBS binds one mole of heme per subunit by determining both the heme and the iron content of the enzyme.	Heme	109-113	cystathionine beta-synthase	Homo sapiens	46-49
18060852-8	2008	Furthermore, we have shown unequivocally that CBS binds one mole of heme per subunit by determining both the heme and the iron content of the enzyme.	Iron	122-126	cystathionine beta-synthase	Homo sapiens	46-49
18060852-10	2008	Finally, we show that CBS is stimulated by S-adenosyl- l-methionine but not its analogs.	S-Adenosylmethionine	43-67	cystathionine beta-synthase	Homo sapiens	22-25
17629356-2	2008	In the mammalian CNS, H2S is formed from the amino acid cysteine by the action of cystathionine beta-synthase (CBS) with serine (Ser) as the by-product.	Hydrogen Sulfide	22-25	cystathionine beta-synthase	Homo sapiens	82-109
18608712-11	2008	It may be due to either the inhibition of cystathionine-beta-synthase, an enzyme required in the metabolism of Hcy, by the drug and/or the liver dysfunction.	Homocysteine	111-114	cystathionine beta-synthase	Homo sapiens	42-69
17629356-2	2008	In the mammalian CNS, H2S is formed from the amino acid cysteine by the action of cystathionine beta-synthase (CBS) with serine (Ser) as the by-product.	Hydrogen Sulfide	22-25	cystathionine beta-synthase	Homo sapiens	111-114
17629356-2	2008	In the mammalian CNS, H2S is formed from the amino acid cysteine by the action of cystathionine beta-synthase (CBS) with serine (Ser) as the by-product.	amino acid cysteine	45-64	cystathionine beta-synthase	Homo sapiens	82-109
17629356-2	2008	In the mammalian CNS, H2S is formed from the amino acid cysteine by the action of cystathionine beta-synthase (CBS) with serine (Ser) as the by-product.	amino acid cysteine	45-64	cystathionine beta-synthase	Homo sapiens	111-114
17629356-2	2008	In the mammalian CNS, H2S is formed from the amino acid cysteine by the action of cystathionine beta-synthase (CBS) with serine (Ser) as the by-product.	Serine	121-127	cystathionine beta-synthase	Homo sapiens	82-109
17629356-2	2008	In the mammalian CNS, H2S is formed from the amino acid cysteine by the action of cystathionine beta-synthase (CBS) with serine (Ser) as the by-product.	Serine	121-127	cystathionine beta-synthase	Homo sapiens	111-114
17629356-3	2008	As CBS is a calcium and calmodulin dependent enzyme, the biosynthesis of H2S should be acutely controlled by the intracellular concentration of calcium.	Hydrogen Sulfide	73-76	cystathionine beta-synthase	Homo sapiens	3-6
17629356-3	2008	As CBS is a calcium and calmodulin dependent enzyme, the biosynthesis of H2S should be acutely controlled by the intracellular concentration of calcium.	Calcium	12-19	cystathionine beta-synthase	Homo sapiens	3-6
17629356-4	2008	In addition, it is also regulated by S-adenosylmethionine which acts as an allosteric activator of CBS.	S-Adenosylmethionine	37-57	cystathionine beta-synthase	Homo sapiens	99-102
17855772-12	2007	Transfection of endothelial cells with cystathionine-beta-synthase (CBS) gene construct, which converts Hcy to cystathionine, reduced Hcy accumulation in high methionine-fed cells.	Homocysteine	104-107	cystathionine beta-synthase	Homo sapiens	39-66
18020381-0	2007	Sorption of a fluorescent whitening agent (Tinopal CBS) onto modified cellulose fibers in the presence of surfactants and salt.	Cellulose	70-79	cystathionine beta-synthase	Homo sapiens	51-54
18020381-0	2007	Sorption of a fluorescent whitening agent (Tinopal CBS) onto modified cellulose fibers in the presence of surfactants and salt.	Salts	122-126	cystathionine beta-synthase	Homo sapiens	51-54
18020381-1	2007	The combined effect of salt (10 mmol L(-1)) and surfactants on the sorption of the fluorescent brightener 4,4"-distyrylbiphenyl sodium sulfonate (Tinopal CBS) onto modified cellulose fibers was studied.	4,4"-distyrylbiphenyl sodium sulfonate	106-144	cystathionine beta-synthase	Homo sapiens	154-157
18020381-1	2007	The combined effect of salt (10 mmol L(-1)) and surfactants on the sorption of the fluorescent brightener 4,4"-distyrylbiphenyl sodium sulfonate (Tinopal CBS) onto modified cellulose fibers was studied.	Tinopal	146-153	cystathionine beta-synthase	Homo sapiens	154-157
18020381-1	2007	The combined effect of salt (10 mmol L(-1)) and surfactants on the sorption of the fluorescent brightener 4,4"-distyrylbiphenyl sodium sulfonate (Tinopal CBS) onto modified cellulose fibers was studied.	Cellulose	173-182	cystathionine beta-synthase	Homo sapiens	154-157
18167585-4	2007	For the methane dimer, errors for SCS(N)-(L)MP2/CBS remain in the 0.2-0.3 kcal mol(-1) range, corresponding to a larger relative error of 40-50%.	Methane	8-15	cystathionine beta-synthase	Homo sapiens	48-51
19107218-1	2008	Human cystathionine beta-synthase (CBS) catalyzes the first irreversible step in the transsulfuration pathway and commits homocysteine to the synthesis of cysteine.	Cysteine	126-134	cystathionine beta-synthase	Homo sapiens	6-33
19107218-1	2008	Human cystathionine beta-synthase (CBS) catalyzes the first irreversible step in the transsulfuration pathway and commits homocysteine to the synthesis of cysteine.	Cysteine	126-134	cystathionine beta-synthase	Homo sapiens	35-38
19107218-5	2008	When the substrates for CBS, homocysteine and serine for cystathionine generation and homocysteine and cysteine for H(2)S generation, are added to the sumoylation mixture, they inhibit the sumoylation reaction, but only in the absence of hPc2.	Serine	46-52	cystathionine beta-synthase	Homo sapiens	24-27
19107218-5	2008	When the substrates for CBS, homocysteine and serine for cystathionine generation and homocysteine and cysteine for H(2)S generation, are added to the sumoylation mixture, they inhibit the sumoylation reaction, but only in the absence of hPc2.	Cystathionine	57-70	cystathionine beta-synthase	Homo sapiens	24-27
19107218-5	2008	When the substrates for CBS, homocysteine and serine for cystathionine generation and homocysteine and cysteine for H(2)S generation, are added to the sumoylation mixture, they inhibit the sumoylation reaction, but only in the absence of hPc2.	Cysteine	33-41	cystathionine beta-synthase	Homo sapiens	24-27
19107218-5	2008	When the substrates for CBS, homocysteine and serine for cystathionine generation and homocysteine and cysteine for H(2)S generation, are added to the sumoylation mixture, they inhibit the sumoylation reaction, but only in the absence of hPc2.	Hydrogen Sulfide	116-121	cystathionine beta-synthase	Homo sapiens	24-27
19107218-6	2008	Similarly, the product of the CBS reaction, cystathionine, inhibits sumoylation in the absence of hPc2.	Cystathionine	44-57	cystathionine beta-synthase	Homo sapiens	30-33
17855772-12	2007	Transfection of endothelial cells with cystathionine-beta-synthase (CBS) gene construct, which converts Hcy to cystathionine, reduced Hcy accumulation in high methionine-fed cells.	Homocysteine	104-107	cystathionine beta-synthase	Homo sapiens	68-71
17855772-12	2007	Transfection of endothelial cells with cystathionine-beta-synthase (CBS) gene construct, which converts Hcy to cystathionine, reduced Hcy accumulation in high methionine-fed cells.	Cystathionine	39-52	cystathionine beta-synthase	Homo sapiens	68-71
17855772-12	2007	Transfection of endothelial cells with cystathionine-beta-synthase (CBS) gene construct, which converts Hcy to cystathionine, reduced Hcy accumulation in high methionine-fed cells.	Homocysteine	134-137	cystathionine beta-synthase	Homo sapiens	39-66
17855772-12	2007	Transfection of endothelial cells with cystathionine-beta-synthase (CBS) gene construct, which converts Hcy to cystathionine, reduced Hcy accumulation in high methionine-fed cells.	Homocysteine	134-137	cystathionine beta-synthase	Homo sapiens	68-71
17855772-12	2007	Transfection of endothelial cells with cystathionine-beta-synthase (CBS) gene construct, which converts Hcy to cystathionine, reduced Hcy accumulation in high methionine-fed cells.	Methionine	159-169	cystathionine beta-synthase	Homo sapiens	39-66
17855772-12	2007	Transfection of endothelial cells with cystathionine-beta-synthase (CBS) gene construct, which converts Hcy to cystathionine, reduced Hcy accumulation in high methionine-fed cells.	Methionine	159-169	cystathionine beta-synthase	Homo sapiens	68-71
17855772-16	2007	However, in vitro DZA and CBS gene therapy successfully treated the HHcy-induced inflammatory reaction in the methionine metabolism pathway.	Methionine	110-120	cystathionine beta-synthase	Homo sapiens	26-29
17956124-1	2007	Cystathionine beta-synthase (CBS) is a pyridoxal-5"-phosphate-dependent enzyme that catalyzes the condensation of serine and homocysteine to form cystathionine.	Pyridoxal Phosphate	39-61	cystathionine beta-synthase	Homo sapiens	0-27
17956124-1	2007	Cystathionine beta-synthase (CBS) is a pyridoxal-5"-phosphate-dependent enzyme that catalyzes the condensation of serine and homocysteine to form cystathionine.	Pyridoxal Phosphate	39-61	cystathionine beta-synthase	Homo sapiens	29-32
17956124-1	2007	Cystathionine beta-synthase (CBS) is a pyridoxal-5"-phosphate-dependent enzyme that catalyzes the condensation of serine and homocysteine to form cystathionine.	Serine	114-120	cystathionine beta-synthase	Homo sapiens	0-27
17956124-1	2007	Cystathionine beta-synthase (CBS) is a pyridoxal-5"-phosphate-dependent enzyme that catalyzes the condensation of serine and homocysteine to form cystathionine.	Serine	114-120	cystathionine beta-synthase	Homo sapiens	29-32
17956124-1	2007	Cystathionine beta-synthase (CBS) is a pyridoxal-5"-phosphate-dependent enzyme that catalyzes the condensation of serine and homocysteine to form cystathionine.	Homocysteine	125-137	cystathionine beta-synthase	Homo sapiens	0-27
17956124-1	2007	Cystathionine beta-synthase (CBS) is a pyridoxal-5"-phosphate-dependent enzyme that catalyzes the condensation of serine and homocysteine to form cystathionine.	Homocysteine	125-137	cystathionine beta-synthase	Homo sapiens	29-32
17956124-1	2007	Cystathionine beta-synthase (CBS) is a pyridoxal-5"-phosphate-dependent enzyme that catalyzes the condensation of serine and homocysteine to form cystathionine.	Cystathionine	146-159	cystathionine beta-synthase	Homo sapiens	0-27
17956124-1	2007	Cystathionine beta-synthase (CBS) is a pyridoxal-5"-phosphate-dependent enzyme that catalyzes the condensation of serine and homocysteine to form cystathionine.	Cystathionine	146-159	cystathionine beta-synthase	Homo sapiens	29-32
17956124-2	2007	Mammalian CBS also contains a heme cofactor that has been proposed to allosterically regulate enzyme activity via the heme redox state, with FeII CBS displaying approximately half the activity of FeIII CBS in vitro.	Heme	30-34	cystathionine beta-synthase	Homo sapiens	10-13
17956124-2	2007	Mammalian CBS also contains a heme cofactor that has been proposed to allosterically regulate enzyme activity via the heme redox state, with FeII CBS displaying approximately half the activity of FeIII CBS in vitro.	Heme	30-34	cystathionine beta-synthase	Homo sapiens	146-149
17956124-2	2007	Mammalian CBS also contains a heme cofactor that has been proposed to allosterically regulate enzyme activity via the heme redox state, with FeII CBS displaying approximately half the activity of FeIII CBS in vitro.	Heme	30-34	cystathionine beta-synthase	Homo sapiens	146-149
17956124-2	2007	Mammalian CBS also contains a heme cofactor that has been proposed to allosterically regulate enzyme activity via the heme redox state, with FeII CBS displaying approximately half the activity of FeIII CBS in vitro.	Heme	118-122	cystathionine beta-synthase	Homo sapiens	10-13
17956124-2	2007	Mammalian CBS also contains a heme cofactor that has been proposed to allosterically regulate enzyme activity via the heme redox state, with FeII CBS displaying approximately half the activity of FeIII CBS in vitro.	Heme	118-122	cystathionine beta-synthase	Homo sapiens	146-149
17956124-2	2007	Mammalian CBS also contains a heme cofactor that has been proposed to allosterically regulate enzyme activity via the heme redox state, with FeII CBS displaying approximately half the activity of FeIII CBS in vitro.	Heme	118-122	cystathionine beta-synthase	Homo sapiens	146-149
17956124-5	2007	Additionally, electronic absorption spectroscopy reveals that FeII CBS undergoes a heme ligand exchange to FeII CBS424 when the enzyme is incubated at 37 degrees C and pH 8.6.	Heme	83-87	cystathionine beta-synthase	Homo sapiens	67-70
17537983-7	2007	Our data suggest that testosterone-dependent regulation of human CBS in kidney may contribute to sex-dependent differences in homocysteine transsulfuration.	Testosterone	22-34	cystathionine beta-synthase	Homo sapiens	65-68
17854288-3	2007	In this study, we investigated regulation by testosterone of cystathionine beta-synthase (CBS), which catalyzes the committing step in the transsulfuration pathway.	Testosterone	45-57	cystathionine beta-synthase	Homo sapiens	61-88
17854288-3	2007	In this study, we investigated regulation by testosterone of cystathionine beta-synthase (CBS), which catalyzes the committing step in the transsulfuration pathway.	Testosterone	45-57	cystathionine beta-synthase	Homo sapiens	90-93
17854288-4	2007	We report that testosterone downregulates CBS expression via a posttranscriptional mechanism in the androgen-responsive prostate cancer cell line, LNCaP.	Testosterone	15-27	cystathionine beta-synthase	Homo sapiens	42-45
17854288-5	2007	This diminution in CBS levels is accompanied by a decrease in flux through the transsulfuration pathway and by a lower intracellular glutathione concentration.	Glutathione	133-144	cystathionine beta-synthase	Homo sapiens	19-22
17854288-7	2007	These results demonstrate regulation of the homocysteine-clearing enzyme, CBS, by testosterone and suggest the potential utility of targeting this enzyme as a chemotherapeutic strategy.	Homocysteine	44-56	cystathionine beta-synthase	Homo sapiens	74-77
17854288-7	2007	These results demonstrate regulation of the homocysteine-clearing enzyme, CBS, by testosterone and suggest the potential utility of targeting this enzyme as a chemotherapeutic strategy.	Testosterone	82-94	cystathionine beta-synthase	Homo sapiens	74-77
17948022-2	2007	The production of H2S from L-cysteine is catalysed primarily by two enzymes, cystathionine gamma-lyase and cystathionine beta-synthase.	Hydrogen Sulfide	18-21	cystathionine beta-synthase	Homo sapiens	107-134
17948022-2	2007	The production of H2S from L-cysteine is catalysed primarily by two enzymes, cystathionine gamma-lyase and cystathionine beta-synthase.	Cysteine	27-37	cystathionine beta-synthase	Homo sapiens	107-134
17537983-0	2007	Testosterone regulation of renal cystathionine beta-synthase: implications for sex-dependent differences in plasma homocysteine levels.	Testosterone	0-12	cystathionine beta-synthase	Homo sapiens	33-60
17537983-7	2007	Our data suggest that testosterone-dependent regulation of human CBS in kidney may contribute to sex-dependent differences in homocysteine transsulfuration.	Homocysteine	126-138	cystathionine beta-synthase	Homo sapiens	65-68
17537983-0	2007	Testosterone regulation of renal cystathionine beta-synthase: implications for sex-dependent differences in plasma homocysteine levels.	Homocysteine	115-127	cystathionine beta-synthase	Homo sapiens	33-60
17537983-3	2007	One route for intracellular disposal of homocysteine is catalyzed by cystathionine beta-synthase (CBS).	Homocysteine	40-52	cystathionine beta-synthase	Homo sapiens	69-96
17540596-1	2007	Missense mutations in the cystathionine beta-synthase (CBS) gene, such as I278T, are responsible for CBS deficiency, the most common inherited disorder in sulfur metabolism.	Sulfur	155-161	cystathionine beta-synthase	Homo sapiens	26-53
17537983-3	2007	One route for intracellular disposal of homocysteine is catalyzed by cystathionine beta-synthase (CBS).	Homocysteine	40-52	cystathionine beta-synthase	Homo sapiens	98-101
17540596-1	2007	Missense mutations in the cystathionine beta-synthase (CBS) gene, such as I278T, are responsible for CBS deficiency, the most common inherited disorder in sulfur metabolism.	Sulfur	155-161	cystathionine beta-synthase	Homo sapiens	55-58
17540596-2	2007	Expression of human mutant CBS proteins in Saccharomyces cerevisiae reveals that most disease causing mutations severely inhibit enzyme activity and cannot support growth of yeast on cysteine-free media.	Cysteine	183-191	cystathionine beta-synthase	Homo sapiens	27-30
17540596-3	2007	Here, we show that the osmolyte chemical chaperones glycerol, trimethylamine-N-oxide, dimethylsulfoxide, proline or sorbitol, when added to yeast media, allows growth on cysteine-free media and causes increased enzyme activity from I278T and three other mutant CBS proteins.	Glycerol	52-60	cystathionine beta-synthase	Homo sapiens	261-264
17540596-3	2007	Here, we show that the osmolyte chemical chaperones glycerol, trimethylamine-N-oxide, dimethylsulfoxide, proline or sorbitol, when added to yeast media, allows growth on cysteine-free media and causes increased enzyme activity from I278T and three other mutant CBS proteins.	trimethyloxamine	62-84	cystathionine beta-synthase	Homo sapiens	261-264
17540596-3	2007	Here, we show that the osmolyte chemical chaperones glycerol, trimethylamine-N-oxide, dimethylsulfoxide, proline or sorbitol, when added to yeast media, allows growth on cysteine-free media and causes increased enzyme activity from I278T and three other mutant CBS proteins.	Dimethyl Sulfoxide	86-103	cystathionine beta-synthase	Homo sapiens	261-264
17540596-3	2007	Here, we show that the osmolyte chemical chaperones glycerol, trimethylamine-N-oxide, dimethylsulfoxide, proline or sorbitol, when added to yeast media, allows growth on cysteine-free media and causes increased enzyme activity from I278T and three other mutant CBS proteins.	Proline	105-112	cystathionine beta-synthase	Homo sapiens	261-264
17540596-3	2007	Here, we show that the osmolyte chemical chaperones glycerol, trimethylamine-N-oxide, dimethylsulfoxide, proline or sorbitol, when added to yeast media, allows growth on cysteine-free media and causes increased enzyme activity from I278T and three other mutant CBS proteins.	Sorbitol	116-124	cystathionine beta-synthase	Homo sapiens	261-264
17540596-3	2007	Here, we show that the osmolyte chemical chaperones glycerol, trimethylamine-N-oxide, dimethylsulfoxide, proline or sorbitol, when added to yeast media, allows growth on cysteine-free media and causes increased enzyme activity from I278T and three other mutant CBS proteins.	Cysteine	170-178	cystathionine beta-synthase	Homo sapiens	261-264
17327360-0	2007	Mutations in methylenetetrahydrofolate reductase or cystathionine beta-synthase gene, or a high-methionine diet, increase homocysteine thiolactone levels in humans and mice.	Thiolactone	135-146	cystathionine beta-synthase	Homo sapiens	52-79
17327360-5	2007	Here we show that plasma Hcy-thiolactone is elevated 59-fold and 72-fold in human patients with hyperhomocysteinemia secondary to mutations in methylenetetrahydrofolate reductase and cystathionine beta-synthase genes, respectively.	homocysteine thiolactone	25-40	cystathionine beta-synthase	Homo sapiens	183-210
17452784-0	2007	Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP.	Adenosine Monophosphate	75-78	cystathionine beta-synthase	Homo sapiens	15-18
17650588-1	2007	Hydrogen sulphide (H2S), a signaling gasotransmitter and a potent vasorelaxant is endogenously produced by the enzymes cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).	Hydrogen Sulfide	0-17	cystathionine beta-synthase	Homo sapiens	119-146
17650588-1	2007	Hydrogen sulphide (H2S), a signaling gasotransmitter and a potent vasorelaxant is endogenously produced by the enzymes cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).	Hydrogen Sulfide	19-22	cystathionine beta-synthase	Homo sapiens	119-146
17452784-0	2007	Structure of a CBS-domain pair from the regulatory gamma1 subunit of human AMPK in complex with AMP and ZMP.	AICA ribonucleotide	104-107	cystathionine beta-synthase	Homo sapiens	15-18
17452784-1	2007	AMP-activated kinase (AMPK) is central to sensing energy status in eukaryotic cells via binding of AMP and ATP to CBS (cystathionine beta-synthase) domains in the regulatory gamma subunit.	Adenosine Monophosphate	0-3	cystathionine beta-synthase	Homo sapiens	114-117
17452784-1	2007	AMP-activated kinase (AMPK) is central to sensing energy status in eukaryotic cells via binding of AMP and ATP to CBS (cystathionine beta-synthase) domains in the regulatory gamma subunit.	Adenosine Monophosphate	0-3	cystathionine beta-synthase	Homo sapiens	119-146
17452784-1	2007	AMP-activated kinase (AMPK) is central to sensing energy status in eukaryotic cells via binding of AMP and ATP to CBS (cystathionine beta-synthase) domains in the regulatory gamma subunit.	Adenosine Triphosphate	107-110	cystathionine beta-synthase	Homo sapiens	114-117
17452784-1	2007	AMP-activated kinase (AMPK) is central to sensing energy status in eukaryotic cells via binding of AMP and ATP to CBS (cystathionine beta-synthase) domains in the regulatory gamma subunit.	Adenosine Triphosphate	107-110	cystathionine beta-synthase	Homo sapiens	119-146
17452784-2	2007	The structure of a CBS-domain pair from human AMPK gamma1 in complex with the physiological activator AMP and the pharmacological activator ZMP (AICAR) is presented.	Adenosine Monophosphate	46-49	cystathionine beta-synthase	Homo sapiens	19-22
17452784-2	2007	The structure of a CBS-domain pair from human AMPK gamma1 in complex with the physiological activator AMP and the pharmacological activator ZMP (AICAR) is presented.	AICA ribonucleotide	140-143	cystathionine beta-synthase	Homo sapiens	19-22
17352495-1	2007	Cystathionine beta-synthase catalyzes the condensation of serine and homocysteine to yield cystathionine and is the single most common locus of mutations associated with homocystinuria.	Serine	58-64	cystathionine beta-synthase	Homo sapiens	0-27
17352495-1	2007	Cystathionine beta-synthase catalyzes the condensation of serine and homocysteine to yield cystathionine and is the single most common locus of mutations associated with homocystinuria.	Homocysteine	69-81	cystathionine beta-synthase	Homo sapiens	0-27
17352495-1	2007	Cystathionine beta-synthase catalyzes the condensation of serine and homocysteine to yield cystathionine and is the single most common locus of mutations associated with homocystinuria.	Cystathionine	91-104	cystathionine beta-synthase	Homo sapiens	0-27
17069888-1	2006	Human cystathionine beta-synthase plays a key role in maintaining low intracellular levels of homocysteine and is unique in being a pyridoxal phosphate-dependent enzyme that is a hemeprotein.	Homocysteine	94-106	cystathionine beta-synthase	Homo sapiens	6-33
17072863-1	2007	Homozygosity or compound heterozygosity for the c.833T&gt;C transition (p.I278 T) in the cystathionine beta-synthase (CBS) gene represents the most common cause of pyridoxine-responsive homocystinuria in Western Eurasians.	Pyridoxine	164-174	cystathionine beta-synthase	Homo sapiens	89-116
17072863-1	2007	Homozygosity or compound heterozygosity for the c.833T&gt;C transition (p.I278 T) in the cystathionine beta-synthase (CBS) gene represents the most common cause of pyridoxine-responsive homocystinuria in Western Eurasians.	Pyridoxine	164-174	cystathionine beta-synthase	Homo sapiens	118-121
17305530-2	2007	Increased plasma levels of homocysteine can be the result of mutations in the enzymes responsible for homocysteine metabolism, particularly cystathionine-beta synthase (CBS) and 5,10-methylenetetrahydrofolate reductase (MTHFR).	Homocysteine	27-39	cystathionine beta-synthase	Homo sapiens	140-167
17377202-3	2007	H(2)S is synthesized from L-cysteine by either cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), both using pyridoxal 5"-phosphate (vitamin B(6)) as a cofactor.	Hydrogen Sulfide	0-5	cystathionine beta-synthase	Homo sapiens	47-74
17377202-3	2007	H(2)S is synthesized from L-cysteine by either cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), both using pyridoxal 5"-phosphate (vitamin B(6)) as a cofactor.	Cysteine	26-36	cystathionine beta-synthase	Homo sapiens	47-74
17377202-3	2007	H(2)S is synthesized from L-cysteine by either cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), both using pyridoxal 5"-phosphate (vitamin B(6)) as a cofactor.	Pyridoxal Phosphate	128-150	cystathionine beta-synthase	Homo sapiens	47-74
17377202-3	2007	H(2)S is synthesized from L-cysteine by either cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), both using pyridoxal 5"-phosphate (vitamin B(6)) as a cofactor.	Niacinamide	152-161	cystathionine beta-synthase	Homo sapiens	47-74
17202841-6	2006	A recombinant adeno- associated virus vector carrying human CBS cDNA (rAAV-hCBS) was constructed and administered to CBS-/- mice by intramuscular (IM) and intraperitoneal (IP) injections.	raav-hcbs	70-79	cystathionine beta-synthase	Homo sapiens	60-63
17046819-3	2006	An important intermediate in GSH-based redox metabolism is homocysteine, which can undergo transmethylation via methionine synthase (MS) or transsulfuration via cystathionine beta-synthase (CBS).	Glutathione	29-32	cystathionine beta-synthase	Homo sapiens	190-193
17046819-3	2006	An important intermediate in GSH-based redox metabolism is homocysteine, which can undergo transmethylation via methionine synthase (MS) or transsulfuration via cystathionine beta-synthase (CBS).	Homocysteine	59-71	cystathionine beta-synthase	Homo sapiens	190-193
17069888-1	2006	Human cystathionine beta-synthase plays a key role in maintaining low intracellular levels of homocysteine and is unique in being a pyridoxal phosphate-dependent enzyme that is a hemeprotein.	Pyridoxal Phosphate	132-151	cystathionine beta-synthase	Homo sapiens	6-33
17087506-1	2006	Cystathionine beta-synthase (CBS) catalyzes the first irreversible step in the transsulfuration pathway and commits the toxic metabolite, homocysteine, to the synthesis of cysteine.	Homocysteine	138-150	cystathionine beta-synthase	Homo sapiens	0-27
17125312-1	2006	The sigma- and pi-bond strengths for the molecules BH2NH2, BH2PH2, AlH2NH2, and AlH2PH2 have been calculated by using ab initio molecular electronic structure theory at the CCSD(T)/CBS level.	alh2ph2	80-87	cystathionine beta-synthase	Homo sapiens	181-184
17087506-1	2006	Cystathionine beta-synthase (CBS) catalyzes the first irreversible step in the transsulfuration pathway and commits the toxic metabolite, homocysteine, to the synthesis of cysteine.	Homocysteine	138-150	cystathionine beta-synthase	Homo sapiens	29-32
17087506-1	2006	Cystathionine beta-synthase (CBS) catalyzes the first irreversible step in the transsulfuration pathway and commits the toxic metabolite, homocysteine, to the synthesis of cysteine.	Cysteine	142-150	cystathionine beta-synthase	Homo sapiens	0-27
17087506-1	2006	Cystathionine beta-synthase (CBS) catalyzes the first irreversible step in the transsulfuration pathway and commits the toxic metabolite, homocysteine, to the synthesis of cysteine.	Cysteine	142-150	cystathionine beta-synthase	Homo sapiens	29-32
17101327-3	2006	METHODS: We used immunohistochemistry to detect H(2)S-producing enzymes cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS) in enteric neurons, Ussing chambers to measure mucosal ion secretion, and neuroimaging with voltage- and Ca(++)-sensitive dyes to record H(2)S effects on guinea-pig and human enteric neurons.	Hydrogen Sulfide	48-53	cystathionine beta-synthase	Homo sapiens	137-140
17101327-3	2006	METHODS: We used immunohistochemistry to detect H(2)S-producing enzymes cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS) in enteric neurons, Ussing chambers to measure mucosal ion secretion, and neuroimaging with voltage- and Ca(++)-sensitive dyes to record H(2)S effects on guinea-pig and human enteric neurons.	Hydrogen Sulfide	279-284	cystathionine beta-synthase	Homo sapiens	137-140
17101327-8	2006	The endogenous H(2)S donor L-cysteine also induced secretion that was diminished significantly by capsaicin desensitization, the CBS inhibitor amino-oxyacetic acid, and the CSE inhibitor propargylglycine.	Hydrogen Sulfide	15-20	cystathionine beta-synthase	Homo sapiens	129-132
16984962-4	2006	Cbs KO females were infertile, showed alterations in the estrus cycle and an increased progesterone response during pseudo-pregnancy induction.	Progesterone	87-99	cystathionine beta-synthase	Homo sapiens	0-3
17101327-8	2006	The endogenous H(2)S donor L-cysteine also induced secretion that was diminished significantly by capsaicin desensitization, the CBS inhibitor amino-oxyacetic acid, and the CSE inhibitor propargylglycine.	Cysteine	27-37	cystathionine beta-synthase	Homo sapiens	129-132
17101327-8	2006	The endogenous H(2)S donor L-cysteine also induced secretion that was diminished significantly by capsaicin desensitization, the CBS inhibitor amino-oxyacetic acid, and the CSE inhibitor propargylglycine.	Aminooxyacetic Acid	143-163	cystathionine beta-synthase	Homo sapiens	129-132
17133733-3	2006	However, when normal metabolism is disturbed, due to deficiency of cystathionine-beta-synthase, which requires vit B6 for activation, Hcy is accumulated in the blood with an increase of methionine, resulting into mental retardation (homocystinuria type I).	vit b6	111-117	cystathionine beta-synthase	Homo sapiens	67-94
16941496-5	2006	Cystathionine beta-synthase (CBS) is a key enzyme of methionine metabolism.	Methionine	53-63	cystathionine beta-synthase	Homo sapiens	0-27
16941496-5	2006	Cystathionine beta-synthase (CBS) is a key enzyme of methionine metabolism.	Methionine	53-63	cystathionine beta-synthase	Homo sapiens	29-32
16941496-6	2006	The CBS variant c.844_845ins68 (p.-) may influence the availability of activated methionine as well as of glutathione.	Methionine	81-91	cystathionine beta-synthase	Homo sapiens	4-7
16941496-6	2006	The CBS variant c.844_845ins68 (p.-) may influence the availability of activated methionine as well as of glutathione.	Glutathione	106-117	cystathionine beta-synthase	Homo sapiens	4-7
16791140-0	2006	Association of a 31 bp VNTR in the CBS gene with postload homocysteine concentrations in the Framingham Offspring Study.	Homocysteine	58-70	cystathionine beta-synthase	Homo sapiens	35-38
16791140-2	2006	Recently, we described the association of a 31 bp variable number of tandem repeats (VNTR) in the cystathionine beta-synthase (CBS) gene with both CBS enzyme activity and tHcy concentrations.	thcy	171-175	cystathionine beta-synthase	Homo sapiens	98-125
16791140-2	2006	Recently, we described the association of a 31 bp variable number of tandem repeats (VNTR) in the cystathionine beta-synthase (CBS) gene with both CBS enzyme activity and tHcy concentrations.	thcy	171-175	cystathionine beta-synthase	Homo sapiens	127-130
16791140-4	2006	We observed a positive association between the number of repeat units of the CBS 31 bp VNTR and both postload and delta tHcy concentrations.	delta thcy	114-124	cystathionine beta-synthase	Homo sapiens	77-80
17133733-3	2006	However, when normal metabolism is disturbed, due to deficiency of cystathionine-beta-synthase, which requires vit B6 for activation, Hcy is accumulated in the blood with an increase of methionine, resulting into mental retardation (homocystinuria type I).	Homocysteine	134-137	cystathionine beta-synthase	Homo sapiens	67-94
17133733-3	2006	However, when normal metabolism is disturbed, due to deficiency of cystathionine-beta-synthase, which requires vit B6 for activation, Hcy is accumulated in the blood with an increase of methionine, resulting into mental retardation (homocystinuria type I).	Methionine	186-196	cystathionine beta-synthase	Homo sapiens	67-94
17004132-2	2006	Formed homocysteine is either catabolized into cystathionine (transsulfuration pathway) by cystathionine beta-synthase, or remethylated into methionine (remethylation pathway) by methionine synthase.	Homocysteine	7-19	cystathionine beta-synthase	Homo sapiens	91-118
17004132-2	2006	Formed homocysteine is either catabolized into cystathionine (transsulfuration pathway) by cystathionine beta-synthase, or remethylated into methionine (remethylation pathway) by methionine synthase.	Cystathionine	47-60	cystathionine beta-synthase	Homo sapiens	91-118
17004132-7	2006	Oxidative stress can increase cystathionine beta-synthase activity that switches methyl cycles from remethylation into transsulfuration pathway to maintain the intracellular glutathione pool (essential for the redox-regulating capacity of cells) via an adaptive process.	Glutathione	174-185	cystathionine beta-synthase	Homo sapiens	30-57
16885444-4	2006	Alternatively, yeast and some bacteria assimilate sulfur into homocysteine, which serves as a sulfhydryl group donor in the synthesis of cysteine by reverse transsulfurylation with a cystathionine-beta-synthase and cystathionine-gamma-lyase.	Sulfur	50-56	cystathionine beta-synthase	Homo sapiens	183-210
16953589-1	2006	Cystathionine beta-synthase (CBS) is a tetrameric heme protein that catalyzes the PLP-dependent condensation of serine and homocysteine to cystathionine.	Cystathionine	139-152	cystathionine beta-synthase	Homo sapiens	0-27
16953589-1	2006	Cystathionine beta-synthase (CBS) is a tetrameric heme protein that catalyzes the PLP-dependent condensation of serine and homocysteine to cystathionine.	Cystathionine	139-152	cystathionine beta-synthase	Homo sapiens	29-32
16953589-2	2006	CBS occupies a crucial regulatory position between the methionine cycle and transsulfuration.	Methionine	55-65	cystathionine beta-synthase	Homo sapiens	0-3
16953589-3	2006	Human CBS contains 11 cysteine residues that are highly conserved in mammals but completely absent in the yeast enzyme, which catalyzes an identical reaction, suggesting a possible regulatory role for some of these residues.	Cysteine	22-30	cystathionine beta-synthase	Homo sapiens	6-9
16953589-4	2006	In this report, we demonstrate that in both the presence and absence of the CBS allosteric regulator S-adenosyl-l-methionine (AdoMet), only C15 and C431 of human CBS are solvent accessible.	S-Adenosylmethionine	101-124	cystathionine beta-synthase	Homo sapiens	76-79
16953589-4	2006	In this report, we demonstrate that in both the presence and absence of the CBS allosteric regulator S-adenosyl-l-methionine (AdoMet), only C15 and C431 of human CBS are solvent accessible.	S-Adenosylmethionine	101-124	cystathionine beta-synthase	Homo sapiens	162-165
16953589-4	2006	In this report, we demonstrate that in both the presence and absence of the CBS allosteric regulator S-adenosyl-l-methionine (AdoMet), only C15 and C431 of human CBS are solvent accessible.	S-Adenosylmethionine	126-132	cystathionine beta-synthase	Homo sapiens	76-79
16953589-4	2006	In this report, we demonstrate that in both the presence and absence of the CBS allosteric regulator S-adenosyl-l-methionine (AdoMet), only C15 and C431 of human CBS are solvent accessible.	S-Adenosylmethionine	126-132	cystathionine beta-synthase	Homo sapiens	162-165
16953589-0	2006	Solvent-accessible cysteines in human cystathionine beta-synthase: crucial role of cysteine 431 in S-adenosyl-L-methionine binding.	Cysteine	19-28	cystathionine beta-synthase	Homo sapiens	38-65
16953589-0	2006	Solvent-accessible cysteines in human cystathionine beta-synthase: crucial role of cysteine 431 in S-adenosyl-L-methionine binding.	Cysteine	19-27	cystathionine beta-synthase	Homo sapiens	38-65
16953589-0	2006	Solvent-accessible cysteines in human cystathionine beta-synthase: crucial role of cysteine 431 in S-adenosyl-L-methionine binding.	S-Adenosylmethionine	99-122	cystathionine beta-synthase	Homo sapiens	38-65
16953589-1	2006	Cystathionine beta-synthase (CBS) is a tetrameric heme protein that catalyzes the PLP-dependent condensation of serine and homocysteine to cystathionine.	Serine	112-118	cystathionine beta-synthase	Homo sapiens	0-27
16953589-1	2006	Cystathionine beta-synthase (CBS) is a tetrameric heme protein that catalyzes the PLP-dependent condensation of serine and homocysteine to cystathionine.	Serine	112-118	cystathionine beta-synthase	Homo sapiens	29-32
16953589-1	2006	Cystathionine beta-synthase (CBS) is a tetrameric heme protein that catalyzes the PLP-dependent condensation of serine and homocysteine to cystathionine.	Homocysteine	123-135	cystathionine beta-synthase	Homo sapiens	0-27
16953589-1	2006	Cystathionine beta-synthase (CBS) is a tetrameric heme protein that catalyzes the PLP-dependent condensation of serine and homocysteine to cystathionine.	Homocysteine	123-135	cystathionine beta-synthase	Homo sapiens	29-32
16885444-4	2006	Alternatively, yeast and some bacteria assimilate sulfur into homocysteine, which serves as a sulfhydryl group donor in the synthesis of cysteine by reverse transsulfurylation with a cystathionine-beta-synthase and cystathionine-gamma-lyase.	Homocysteine	62-74	cystathionine beta-synthase	Homo sapiens	183-210
16885444-4	2006	Alternatively, yeast and some bacteria assimilate sulfur into homocysteine, which serves as a sulfhydryl group donor in the synthesis of cysteine by reverse transsulfurylation with a cystathionine-beta-synthase and cystathionine-gamma-lyase.	Cysteine	66-74	cystathionine beta-synthase	Homo sapiens	183-210
16428267-1	2006	Endogenous hydrogen sulfide (H(2)S) is naturally synthesized in various types of mammalian cells from l-cysteine in a reaction catalyzed by two enzymes, cystathionine-gamma-lyase (CSE) and/or cystathionine-beta-synthase.	Cysteine	102-112	cystathionine beta-synthase	Homo sapiens	192-219
16781459-1	2006	Hydrogen sulfide (H(2)S), a regulatory gaseous molecule that is endogenously synthesized by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS) from L-cysteine (L-Cys) metabolism, is a putative vasodilator, and its role in nitric oxide (NO) production is unexplored.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	131-158
16781459-1	2006	Hydrogen sulfide (H(2)S), a regulatory gaseous molecule that is endogenously synthesized by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS) from L-cysteine (L-Cys) metabolism, is a putative vasodilator, and its role in nitric oxide (NO) production is unexplored.	Hydrogen Sulfide	0-16	cystathionine beta-synthase	Homo sapiens	160-163
16781459-1	2006	Hydrogen sulfide (H(2)S), a regulatory gaseous molecule that is endogenously synthesized by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS) from L-cysteine (L-Cys) metabolism, is a putative vasodilator, and its role in nitric oxide (NO) production is unexplored.	Hydrogen Sulfide	18-23	cystathionine beta-synthase	Homo sapiens	131-158
16781459-1	2006	Hydrogen sulfide (H(2)S), a regulatory gaseous molecule that is endogenously synthesized by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS) from L-cysteine (L-Cys) metabolism, is a putative vasodilator, and its role in nitric oxide (NO) production is unexplored.	Hydrogen Sulfide	18-23	cystathionine beta-synthase	Homo sapiens	160-163
16781459-1	2006	Hydrogen sulfide (H(2)S), a regulatory gaseous molecule that is endogenously synthesized by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS) from L-cysteine (L-Cys) metabolism, is a putative vasodilator, and its role in nitric oxide (NO) production is unexplored.	Cysteine	170-180	cystathionine beta-synthase	Homo sapiens	131-158
16781459-1	2006	Hydrogen sulfide (H(2)S), a regulatory gaseous molecule that is endogenously synthesized by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS) from L-cysteine (L-Cys) metabolism, is a putative vasodilator, and its role in nitric oxide (NO) production is unexplored.	Cysteine	170-180	cystathionine beta-synthase	Homo sapiens	160-163
16781459-1	2006	Hydrogen sulfide (H(2)S), a regulatory gaseous molecule that is endogenously synthesized by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS) from L-cysteine (L-Cys) metabolism, is a putative vasodilator, and its role in nitric oxide (NO) production is unexplored.	Cysteine	182-187	cystathionine beta-synthase	Homo sapiens	131-158
16781459-1	2006	Hydrogen sulfide (H(2)S), a regulatory gaseous molecule that is endogenously synthesized by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS) from L-cysteine (L-Cys) metabolism, is a putative vasodilator, and its role in nitric oxide (NO) production is unexplored.	Cysteine	182-187	cystathionine beta-synthase	Homo sapiens	160-163
16781459-1	2006	Hydrogen sulfide (H(2)S), a regulatory gaseous molecule that is endogenously synthesized by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS) from L-cysteine (L-Cys) metabolism, is a putative vasodilator, and its role in nitric oxide (NO) production is unexplored.	Nitric Oxide	244-256	cystathionine beta-synthase	Homo sapiens	131-158
16781459-1	2006	Hydrogen sulfide (H(2)S), a regulatory gaseous molecule that is endogenously synthesized by cystathionine gamma-lyase (CSE) and/or cystathionine beta-synthase (CBS) from L-cysteine (L-Cys) metabolism, is a putative vasodilator, and its role in nitric oxide (NO) production is unexplored.	Nitric Oxide	244-256	cystathionine beta-synthase	Homo sapiens	160-163
16428267-1	2006	Endogenous hydrogen sulfide (H(2)S) is naturally synthesized in various types of mammalian cells from l-cysteine in a reaction catalyzed by two enzymes, cystathionine-gamma-lyase (CSE) and/or cystathionine-beta-synthase.	Hydrogen Sulfide	11-27	cystathionine beta-synthase	Homo sapiens	192-219
16428267-1	2006	Endogenous hydrogen sulfide (H(2)S) is naturally synthesized in various types of mammalian cells from l-cysteine in a reaction catalyzed by two enzymes, cystathionine-gamma-lyase (CSE) and/or cystathionine-beta-synthase.	Hydrogen Sulfide	29-34	cystathionine beta-synthase	Homo sapiens	192-219
16505479-0	2006	Dynamics of carbon monoxide binding to cystathionine beta-synthase.	Carbon Monoxide	12-27	cystathionine beta-synthase	Homo sapiens	39-66
16702334-6	2006	Met homeostasis is regulated by subtle competitive interactions between transsulfuration and remethylation pathways of homocysteine (Hcy) and by the actual level of TBN reserves working as a direct sensor of cystathionine-beta-synthase activity.	2-Propanamine, 2-methyl-N-[(3,5,6-trimethyl-2-pyrazinyl)methylene]-, N-oxide	165-168	cystathionine beta-synthase	Homo sapiens	208-235
16702349-5	2006	Plasma Hcy-thiolactone levels are elevated in human subjects with hyperhomocysteinemia caused by mutations in CBS or MTHFR genes.	homocysteine thiolactone	7-22	cystathionine beta-synthase	Homo sapiens	110-113
16505479-1	2006	Cystathionine beta-synthase (CBS) condenses homocysteine, a toxic metabolite, with serine in a pyridoxal phosphate-dependent reaction.	Homocysteine	44-56	cystathionine beta-synthase	Homo sapiens	0-27
16505479-1	2006	Cystathionine beta-synthase (CBS) condenses homocysteine, a toxic metabolite, with serine in a pyridoxal phosphate-dependent reaction.	Homocysteine	44-56	cystathionine beta-synthase	Homo sapiens	29-32
16505479-1	2006	Cystathionine beta-synthase (CBS) condenses homocysteine, a toxic metabolite, with serine in a pyridoxal phosphate-dependent reaction.	Serine	83-89	cystathionine beta-synthase	Homo sapiens	0-27
16505479-1	2006	Cystathionine beta-synthase (CBS) condenses homocysteine, a toxic metabolite, with serine in a pyridoxal phosphate-dependent reaction.	Serine	83-89	cystathionine beta-synthase	Homo sapiens	29-32
16505479-1	2006	Cystathionine beta-synthase (CBS) condenses homocysteine, a toxic metabolite, with serine in a pyridoxal phosphate-dependent reaction.	Pyridoxal Phosphate	95-114	cystathionine beta-synthase	Homo sapiens	0-27
16505479-1	2006	Cystathionine beta-synthase (CBS) condenses homocysteine, a toxic metabolite, with serine in a pyridoxal phosphate-dependent reaction.	Pyridoxal Phosphate	95-114	cystathionine beta-synthase	Homo sapiens	29-32
16575899-11	2006	Taking into consideration that in the one-carbon metabolism cystathionine beta-synthase (CBS) catalyzes Hcy in an irreversible way, and that CBS gene is located in chromosome 21, fetuses and infants with DS have functional folate deficiency due to overexpression of CBS.	Carbon	42-48	cystathionine beta-synthase	Homo sapiens	60-87
16575899-11	2006	Taking into consideration that in the one-carbon metabolism cystathionine beta-synthase (CBS) catalyzes Hcy in an irreversible way, and that CBS gene is located in chromosome 21, fetuses and infants with DS have functional folate deficiency due to overexpression of CBS.	Carbon	42-48	cystathionine beta-synthase	Homo sapiens	89-92
16575899-11	2006	Taking into consideration that in the one-carbon metabolism cystathionine beta-synthase (CBS) catalyzes Hcy in an irreversible way, and that CBS gene is located in chromosome 21, fetuses and infants with DS have functional folate deficiency due to overexpression of CBS.	Homocysteine	104-107	cystathionine beta-synthase	Homo sapiens	60-87
16614071-6	2006	Furthermore, diminished CBS levels are associated with reduced cell viability in hepatoma cells challenged with tert-butyl hydroperoxide.	tert-Butylhydroperoxide	112-136	cystathionine beta-synthase	Homo sapiens	24-27
16575899-11	2006	Taking into consideration that in the one-carbon metabolism cystathionine beta-synthase (CBS) catalyzes Hcy in an irreversible way, and that CBS gene is located in chromosome 21, fetuses and infants with DS have functional folate deficiency due to overexpression of CBS.	Homocysteine	104-107	cystathionine beta-synthase	Homo sapiens	89-92
16619244-0	2006	Contrasting behaviors of mutant cystathionine beta-synthase enzymes associated with pyridoxine response.	Pyridoxine	84-94	cystathionine beta-synthase	Homo sapiens	32-59
16619244-1	2006	Cystathionine beta-synthase (CBS) deficiency is a recessive genetic disorder characterized by extremely elevated levels in plasma homocysteine.	Homocysteine	130-142	cystathionine beta-synthase	Homo sapiens	0-27
16614071-0	2006	S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity.	S-Adenosylmethionine	0-20	cystathionine beta-synthase	Homo sapiens	32-59
16614071-2	2006	The first and committing step in this pathway is catalyzed by cystathionine beta-synthase (CBS), which is subject to complex regulation, including allosteric activation by the methyl donor, S-adenosylmethionine (AdoMet).	S-Adenosylmethionine	190-210	cystathionine beta-synthase	Homo sapiens	62-89
16614071-2	2006	The first and committing step in this pathway is catalyzed by cystathionine beta-synthase (CBS), which is subject to complex regulation, including allosteric activation by the methyl donor, S-adenosylmethionine (AdoMet).	S-Adenosylmethionine	190-210	cystathionine beta-synthase	Homo sapiens	91-94
16614071-2	2006	The first and committing step in this pathway is catalyzed by cystathionine beta-synthase (CBS), which is subject to complex regulation, including allosteric activation by the methyl donor, S-adenosylmethionine (AdoMet).	S-Adenosylmethionine	212-218	cystathionine beta-synthase	Homo sapiens	62-89
16614071-2	2006	The first and committing step in this pathway is catalyzed by cystathionine beta-synthase (CBS), which is subject to complex regulation, including allosteric activation by the methyl donor, S-adenosylmethionine (AdoMet).	S-Adenosylmethionine	212-218	cystathionine beta-synthase	Homo sapiens	91-94
16614071-7	2006	This study uncovers a mechanism by which CBS is allosterically activated by AdoMet under normal conditions but is destabilized under pathological conditions, for redirecting the metabolic flux toward methionine conservation.	Methionine	200-210	cystathionine beta-synthase	Homo sapiens	41-44
16614071-3	2006	In this study, we demonstrate that methionine restriction leads to a &gt;10-fold decrease in CBS protein levels, and pulse proteolysis studies reveal that binding of AdoMet stabilizes the protein against degradation by approximately 12 kcal/mol.	Methionine	35-45	cystathionine beta-synthase	Homo sapiens	93-96
16439695-11	2006	It also appeared that most of the H2S synthesizing activity in the cortex results from the action of cystathionine beta-synthase.	Hydrogen Sulfide	34-37	cystathionine beta-synthase	Homo sapiens	101-128
16613710-3	2006	This study was designed to explore the effect of GABABR on H2S/cystathionine-beta-synthase (CBS) system in recurrent FS.	gababr	49-55	cystathionine beta-synthase	Homo sapiens	59-90
16613710-3	2006	This study was designed to explore the effect of GABABR on H2S/cystathionine-beta-synthase (CBS) system in recurrent FS.	gababr	49-55	cystathionine beta-synthase	Homo sapiens	92-95
16613710-10	2006	The expressions of CBS mRNA and protein were up-regulated in the FS+baclofen group but were down-regulated in the FS+phaclofen group compared with those in the FS group.	Baclofen	68-76	cystathionine beta-synthase	Homo sapiens	19-22
16613710-10	2006	The expressions of CBS mRNA and protein were up-regulated in the FS+baclofen group but were down-regulated in the FS+phaclofen group compared with those in the FS group.	phaclofen	117-126	cystathionine beta-synthase	Homo sapiens	19-22
16613710-11	2006	CONCLUSIONS: GABABR modulated the expression of H2S/CBS system in recurrent FS.	gababr	13-19	cystathionine beta-synthase	Homo sapiens	52-55
16613710-11	2006	CONCLUSIONS: GABABR modulated the expression of H2S/CBS system in recurrent FS.	Hydrogen Sulfide	48-51	cystathionine beta-synthase	Homo sapiens	52-55
16363792-9	2005	When this investigation is taken together with other functional studies of CBS, it provides strong evidence that coordination of Cys52 to the heme iron is crucial for full activity in this enzyme.	Iron	147-151	cystathionine beta-synthase	Homo sapiens	75-78
16460178-3	2006	Although a precise IE value for the 2-C(3)H(7) radical has not been directly determined before due to the poor Franck-Condon factor for the photoionization transition at the ionization threshold, the experimental value deduced indirectly using other known energetic data is found to be in good accord with the present CCSD(T)/CBS prediction.	2-c(3)h(7) radical	36-54	cystathionine beta-synthase	Homo sapiens	326-329
16192316-2	2006	Cystathionine beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) mediate enzymatic generation of H(2)S in mammalian cells.	Hydrogen Sulfide	102-107	cystathionine beta-synthase	Homo sapiens	0-27
16462202-9	2006	This effect of cysteine was abolished by aminooxyacetic acid, an inhibitor of the enzyme cystathionine beta-synthase that converts cysteine to hydrogen sulfide (H2S), indicating that this novel neuromodulator may be acting as a mediator of ischemic brain damage.	Cysteine	15-23	cystathionine beta-synthase	Homo sapiens	89-116
16462202-9	2006	This effect of cysteine was abolished by aminooxyacetic acid, an inhibitor of the enzyme cystathionine beta-synthase that converts cysteine to hydrogen sulfide (H2S), indicating that this novel neuromodulator may be acting as a mediator of ischemic brain damage.	Aminooxyacetic Acid	41-60	cystathionine beta-synthase	Homo sapiens	89-116
16462202-9	2006	This effect of cysteine was abolished by aminooxyacetic acid, an inhibitor of the enzyme cystathionine beta-synthase that converts cysteine to hydrogen sulfide (H2S), indicating that this novel neuromodulator may be acting as a mediator of ischemic brain damage.	Cysteine	131-139	cystathionine beta-synthase	Homo sapiens	89-116
16462202-9	2006	This effect of cysteine was abolished by aminooxyacetic acid, an inhibitor of the enzyme cystathionine beta-synthase that converts cysteine to hydrogen sulfide (H2S), indicating that this novel neuromodulator may be acting as a mediator of ischemic brain damage.	Hydrogen Sulfide	143-159	cystathionine beta-synthase	Homo sapiens	89-116
16462202-9	2006	This effect of cysteine was abolished by aminooxyacetic acid, an inhibitor of the enzyme cystathionine beta-synthase that converts cysteine to hydrogen sulfide (H2S), indicating that this novel neuromodulator may be acting as a mediator of ischemic brain damage.	Hydrogen Sulfide	161-164	cystathionine beta-synthase	Homo sapiens	89-116
16363792-1	2005	Cystathionine beta-synthase (CBS) is a pyridoxal-5"-dependent enzyme that catalyzes the condensation of homocysteine and serine to form cystathionine.	Homocysteine	104-116	cystathionine beta-synthase	Homo sapiens	0-27
16363792-1	2005	Cystathionine beta-synthase (CBS) is a pyridoxal-5"-dependent enzyme that catalyzes the condensation of homocysteine and serine to form cystathionine.	Homocysteine	104-116	cystathionine beta-synthase	Homo sapiens	29-32
16363792-10	2005	We hypothesize that cysteine displacement may serve as a mechanism for CBS inactivation and that second-sphere interactions of the Cys52 thiolate with surrounding residues are responsible for communicating the heme ligand displacement to the CBS active site.	Cysteine	20-28	cystathionine beta-synthase	Homo sapiens	71-74
16363792-1	2005	Cystathionine beta-synthase (CBS) is a pyridoxal-5"-dependent enzyme that catalyzes the condensation of homocysteine and serine to form cystathionine.	Serine	121-127	cystathionine beta-synthase	Homo sapiens	0-27
16363792-10	2005	We hypothesize that cysteine displacement may serve as a mechanism for CBS inactivation and that second-sphere interactions of the Cys52 thiolate with surrounding residues are responsible for communicating the heme ligand displacement to the CBS active site.	cys52 thiolate	131-145	cystathionine beta-synthase	Homo sapiens	71-74
16363792-1	2005	Cystathionine beta-synthase (CBS) is a pyridoxal-5"-dependent enzyme that catalyzes the condensation of homocysteine and serine to form cystathionine.	Serine	121-127	cystathionine beta-synthase	Homo sapiens	29-32
16363792-1	2005	Cystathionine beta-synthase (CBS) is a pyridoxal-5"-dependent enzyme that catalyzes the condensation of homocysteine and serine to form cystathionine.	Cystathionine	136-149	cystathionine beta-synthase	Homo sapiens	0-27
16363792-1	2005	Cystathionine beta-synthase (CBS) is a pyridoxal-5"-dependent enzyme that catalyzes the condensation of homocysteine and serine to form cystathionine.	Cystathionine	136-149	cystathionine beta-synthase	Homo sapiens	29-32
16363792-2	2005	Human CBS is unique in that heme is also required for maximal activity, although the function of heme in this enzyme is presently unclear.	Heme	28-32	cystathionine beta-synthase	Homo sapiens	6-9
16363792-2	2005	Human CBS is unique in that heme is also required for maximal activity, although the function of heme in this enzyme is presently unclear.	Heme	97-101	cystathionine beta-synthase	Homo sapiens	6-9
16363792-3	2005	The study presented herein reveals that the heme of human CBS undergoes a coordination change upon reduction at elevated temperatures.	Heme	44-48	cystathionine beta-synthase	Homo sapiens	58-61
16363792-9	2005	When this investigation is taken together with other functional studies of CBS, it provides strong evidence that coordination of Cys52 to the heme iron is crucial for full activity in this enzyme.	Heme	142-146	cystathionine beta-synthase	Homo sapiens	75-78
16363792-10	2005	We hypothesize that cysteine displacement may serve as a mechanism for CBS inactivation and that second-sphere interactions of the Cys52 thiolate with surrounding residues are responsible for communicating the heme ligand displacement to the CBS active site.	cys52 thiolate	131-145	cystathionine beta-synthase	Homo sapiens	242-245
16363792-10	2005	We hypothesize that cysteine displacement may serve as a mechanism for CBS inactivation and that second-sphere interactions of the Cys52 thiolate with surrounding residues are responsible for communicating the heme ligand displacement to the CBS active site.	Heme	210-214	cystathionine beta-synthase	Homo sapiens	242-245
16096271-2	2005	Most patients have a defect in the cystathionine-beta-synthase, the key enzyme in the conversion of homocysteine to cysteine.	Homocysteine	100-112	cystathionine beta-synthase	Homo sapiens	35-62
16275737-8	2005	However, recent experiments revealing that CBS domains can bind adenosine-containing ligands such ATP, AMP, or S-adenosylmethionine have led to the hypothesis that CBS domains function as sensors of intracellular metabolites.	Adenosine	64-73	cystathionine beta-synthase	Homo sapiens	43-46
16275737-8	2005	However, recent experiments revealing that CBS domains can bind adenosine-containing ligands such ATP, AMP, or S-adenosylmethionine have led to the hypothesis that CBS domains function as sensors of intracellular metabolites.	Adenosine	64-73	cystathionine beta-synthase	Homo sapiens	164-167
16275737-8	2005	However, recent experiments revealing that CBS domains can bind adenosine-containing ligands such ATP, AMP, or S-adenosylmethionine have led to the hypothesis that CBS domains function as sensors of intracellular metabolites.	Adenosine Triphosphate	98-101	cystathionine beta-synthase	Homo sapiens	43-46
16275737-8	2005	However, recent experiments revealing that CBS domains can bind adenosine-containing ligands such ATP, AMP, or S-adenosylmethionine have led to the hypothesis that CBS domains function as sensors of intracellular metabolites.	Adenosine Triphosphate	98-101	cystathionine beta-synthase	Homo sapiens	164-167
16275737-8	2005	However, recent experiments revealing that CBS domains can bind adenosine-containing ligands such ATP, AMP, or S-adenosylmethionine have led to the hypothesis that CBS domains function as sensors of intracellular metabolites.	Adenosine Monophosphate	103-106	cystathionine beta-synthase	Homo sapiens	43-46
16275737-8	2005	However, recent experiments revealing that CBS domains can bind adenosine-containing ligands such ATP, AMP, or S-adenosylmethionine have led to the hypothesis that CBS domains function as sensors of intracellular metabolites.	Adenosine Monophosphate	103-106	cystathionine beta-synthase	Homo sapiens	164-167
16275737-8	2005	However, recent experiments revealing that CBS domains can bind adenosine-containing ligands such ATP, AMP, or S-adenosylmethionine have led to the hypothesis that CBS domains function as sensors of intracellular metabolites.	S-Adenosylmethionine	111-131	cystathionine beta-synthase	Homo sapiens	43-46
16275737-8	2005	However, recent experiments revealing that CBS domains can bind adenosine-containing ligands such ATP, AMP, or S-adenosylmethionine have led to the hypothesis that CBS domains function as sensors of intracellular metabolites.	S-Adenosylmethionine	111-131	cystathionine beta-synthase	Homo sapiens	164-167
16422253-7	2005	CONCLUSION: The elevated plasma Hcy level in AD patients is probably involved in the pathogenesis of AD, which may be due to the environmental factor rather than genetic factors of the mutations of MTHFR and CBS.	Homocysteine	32-35	cystathionine beta-synthase	Homo sapiens	208-211
16306866-5	2005	The genetic defects which, as homozygous genotype, cause high plasma levels of homocysteine are already well known; they lead to an activity reduction of the enzymes responsible for their metabolism, for example: the deficiency of cystathionine beta-synthase; the deficiency of the methylcobalamine production; the deficit of the 5-10 methylenetethrahydrofolate reductase (MTHFR).	Homocysteine	79-91	cystathionine beta-synthase	Homo sapiens	231-258
16306866-5	2005	The genetic defects which, as homozygous genotype, cause high plasma levels of homocysteine are already well known; they lead to an activity reduction of the enzymes responsible for their metabolism, for example: the deficiency of cystathionine beta-synthase; the deficiency of the methylcobalamine production; the deficit of the 5-10 methylenetethrahydrofolate reductase (MTHFR).	mecobalamin	282-298	cystathionine beta-synthase	Homo sapiens	231-258
16245937-1	2005	Cystathionine beta-synthase plays a key role in the intracellular disposal of homocysteine and is the single most common locus of mutations associated with homocystinuria.	Homocysteine	78-90	cystathionine beta-synthase	Homo sapiens	0-27
16096271-2	2005	Most patients have a defect in the cystathionine-beta-synthase, the key enzyme in the conversion of homocysteine to cysteine.	Cysteine	104-112	cystathionine beta-synthase	Homo sapiens	35-62
16105135-1	2005	BACKGROUND: Although steatosis is common in patients with severe hyperhomocysteinemia due to deficiency of cystathionine beta-synthase, there are no satisfactory data on homocysteine concentrations in patients with non-alcoholic fatty liver disease.	Homocysteine	70-82	cystathionine beta-synthase	Homo sapiens	107-134
16230075-1	2005	BACKGROUND &amp; AIMS: Hydrogen sulfide (H(2)S), an endogenous gaseous mediator that causes vasodilation, is generated in mammalian tissues by cystathionine beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).	Adenosine Monophosphate	12-15	cystathionine beta-synthase	Homo sapiens	143-170
16230075-1	2005	BACKGROUND &amp; AIMS: Hydrogen sulfide (H(2)S), an endogenous gaseous mediator that causes vasodilation, is generated in mammalian tissues by cystathionine beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).	Hydrogen Sulfide	23-39	cystathionine beta-synthase	Homo sapiens	143-170
16230075-1	2005	BACKGROUND &amp; AIMS: Hydrogen sulfide (H(2)S), an endogenous gaseous mediator that causes vasodilation, is generated in mammalian tissues by cystathionine beta-synthase (CBS) and cystathionine-gamma-lyase (CSE).	Hydrogen Sulfide	41-46	cystathionine beta-synthase	Homo sapiens	143-170
15972722-1	2005	Cystathionine beta-synthase (CBS) deficiency is a recessive genetic disorder in humans characterized by elevated levels of total plasma homocysteine (tHcy) and frequent thrombosis in humans.	Homocysteine	136-148	cystathionine beta-synthase	Homo sapiens	0-27
15972722-1	2005	Cystathionine beta-synthase (CBS) deficiency is a recessive genetic disorder in humans characterized by elevated levels of total plasma homocysteine (tHcy) and frequent thrombosis in humans.	thcy	150-154	cystathionine beta-synthase	Homo sapiens	0-27
16047261-4	2005	In particular, S-adenosylmethionine acts as a switch between remethylation and transsulfuration through its allosteric inhibition of methylenetetrahydrofolate reductase and activation of cystathionine beta-synthase.	S-Adenosylmethionine	15-35	cystathionine beta-synthase	Homo sapiens	187-214
15958186-6	2005	For comparison purposes, the same hCBS reaction was monitored via a radioactive single time point assay using 14C-(C-1)-labeled L-serine and cysteamine as substrates, counting the thialysine product, following ion exchange chromatography.	Serine	128-136	cystathionine beta-synthase	Homo sapiens	34-38
15958186-6	2005	For comparison purposes, the same hCBS reaction was monitored via a radioactive single time point assay using 14C-(C-1)-labeled L-serine and cysteamine as substrates, counting the thialysine product, following ion exchange chromatography.	Cysteamine	141-151	cystathionine beta-synthase	Homo sapiens	34-38
15958186-6	2005	For comparison purposes, the same hCBS reaction was monitored via a radioactive single time point assay using 14C-(C-1)-labeled L-serine and cysteamine as substrates, counting the thialysine product, following ion exchange chromatography.	S-2-aminoethyl cysteine	180-190	cystathionine beta-synthase	Homo sapiens	34-38
15958186-8	2005	These numbers indicate that, although it possesses a shortened carbon chain and lacks a carboxyl group, cysteamine displays a catalytic efficiency (kcat/Km) with hCBS that is within an order of magnitude of that observed with its natural thiol cosubstrate, L-homocysteine.	Cysteamine	104-114	cystathionine beta-synthase	Homo sapiens	162-166
15890000-6	2005	We also discuss redox regulation of the key enzymes involved in homocysteine clearance: methionine synthase, betaine-homocysteine methyltranferase, and cystathionine beta-synthase.	Homocysteine	64-76	cystathionine beta-synthase	Homo sapiens	109-179
15958186-2	2005	This assay relies upon the finding that hCBS will take cysteamine in place of L-homocysteine, thereby producing thialysine.	Cysteamine	55-65	cystathionine beta-synthase	Homo sapiens	40-44
15958186-2	2005	This assay relies upon the finding that hCBS will take cysteamine in place of L-homocysteine, thereby producing thialysine.	Homocysteine	78-92	cystathionine beta-synthase	Homo sapiens	40-44
15958186-2	2005	This assay relies upon the finding that hCBS will take cysteamine in place of L-homocysteine, thereby producing thialysine.	S-2-aminoethyl cysteine	112-122	cystathionine beta-synthase	Homo sapiens	40-44
15958186-5	2005	Using this four-enzyme couple, we find that Km(app) = 1.2+/-0.2 mM for L-serine and 5.6+/-2.2 mM for cysteamine, with kcat = 1.3+/-0.1s(-1) for the formation of thialysine by hCBS.	Serine	71-79	cystathionine beta-synthase	Homo sapiens	175-179
15958186-5	2005	Using this four-enzyme couple, we find that Km(app) = 1.2+/-0.2 mM for L-serine and 5.6+/-2.2 mM for cysteamine, with kcat = 1.3+/-0.1s(-1) for the formation of thialysine by hCBS.	Cysteamine	101-111	cystathionine beta-synthase	Homo sapiens	175-179
15958186-5	2005	Using this four-enzyme couple, we find that Km(app) = 1.2+/-0.2 mM for L-serine and 5.6+/-2.2 mM for cysteamine, with kcat = 1.3+/-0.1s(-1) for the formation of thialysine by hCBS.	S-2-aminoethyl cysteine	161-171	cystathionine beta-synthase	Homo sapiens	175-179
15958186-6	2005	For comparison purposes, the same hCBS reaction was monitored via a radioactive single time point assay using 14C-(C-1)-labeled L-serine and cysteamine as substrates, counting the thialysine product, following ion exchange chromatography.	Carbon-14	110-113	cystathionine beta-synthase	Homo sapiens	34-38
15890029-0	2005	The role of cystathionine beta-synthase in homocysteine metabolism.	Homocysteine	43-55	cystathionine beta-synthase	Homo sapiens	12-39
15890029-1	2005	Cystathionine beta-synthase (CBS) is the first enzyme in the transsulfuration pathway, catalyzing the conversion of serine and homocysteine to cystathionine and water.	Serine	116-122	cystathionine beta-synthase	Homo sapiens	0-27
15890029-1	2005	Cystathionine beta-synthase (CBS) is the first enzyme in the transsulfuration pathway, catalyzing the conversion of serine and homocysteine to cystathionine and water.	Serine	116-122	cystathionine beta-synthase	Homo sapiens	29-32
15890029-1	2005	Cystathionine beta-synthase (CBS) is the first enzyme in the transsulfuration pathway, catalyzing the conversion of serine and homocysteine to cystathionine and water.	Homocysteine	127-139	cystathionine beta-synthase	Homo sapiens	0-27
15890029-1	2005	Cystathionine beta-synthase (CBS) is the first enzyme in the transsulfuration pathway, catalyzing the conversion of serine and homocysteine to cystathionine and water.	Homocysteine	127-139	cystathionine beta-synthase	Homo sapiens	29-32
15890029-1	2005	Cystathionine beta-synthase (CBS) is the first enzyme in the transsulfuration pathway, catalyzing the conversion of serine and homocysteine to cystathionine and water.	Cystathionine	143-156	cystathionine beta-synthase	Homo sapiens	0-27
15890029-1	2005	Cystathionine beta-synthase (CBS) is the first enzyme in the transsulfuration pathway, catalyzing the conversion of serine and homocysteine to cystathionine and water.	Cystathionine	143-156	cystathionine beta-synthase	Homo sapiens	29-32
15890029-1	2005	Cystathionine beta-synthase (CBS) is the first enzyme in the transsulfuration pathway, catalyzing the conversion of serine and homocysteine to cystathionine and water.	Water	161-166	cystathionine beta-synthase	Homo sapiens	0-27
15890029-1	2005	Cystathionine beta-synthase (CBS) is the first enzyme in the transsulfuration pathway, catalyzing the conversion of serine and homocysteine to cystathionine and water.	Water	161-166	cystathionine beta-synthase	Homo sapiens	29-32
15890029-6	2005	Besides its canonical reaction, CBS can catalyze alternative reactions that produce hydrogen sulfide, a novel neuromodulator in the brain.	Hydrogen Sulfide	84-100	cystathionine beta-synthase	Homo sapiens	32-35
15890029-8	2005	The most common CBS allele is 833T&gt;C (I278T), which is associated with pyridoxine-responsive homocystinuria.	Pyridoxine	74-84	cystathionine beta-synthase	Homo sapiens	16-19
15890029-11	2005	This finding suggests it may be possible to develop drugs that interact with the C-terminal domain of CBS to treat elevated homocysteine in humans.	Homocysteine	124-136	cystathionine beta-synthase	Homo sapiens	102-105
15390307-3	2005	The high event-free survival (EFS) rates of DS AML patients and in particular, patients with megakaryocytic leukemia (AMkL), at least in part reflects an increased sensitivity to cytosine arabinoside (ara-C) secondary to increased expression of the chromosome 21-localized gene, cystathionine-beta-synthase, and potentially global mechanisms which increase the susceptibility of cells to undergo apoptosis.	Cytarabine	201-206	cystathionine beta-synthase	Homo sapiens	279-306
15777277-0	2005	Inhibitory effect of copper on cystathionine beta-synthase activity: protective effect of an analog of the human albumin N-terminus.	Copper	21-27	cystathionine beta-synthase	Homo sapiens	31-58
15777277-1	2005	Copper was added to truncated, recombinant cystathionine beta-synthase (CBS), and the enzyme activity was assessed by measuring the production of cystathionine.	Copper	0-6	cystathionine beta-synthase	Homo sapiens	43-70
15735045-7	2005	Interestingly, markedly reduced CBS expression was seen in the methionine-dependent prostate cancer cell line, PC-3, but not in the methionine-independent cell line, DU-145.	Methionine	63-73	cystathionine beta-synthase	Homo sapiens	32-35
15830093-5	2005	One cause of severe hypehomocys- teinemia (HHcy) is the deficiency of cystathionine beta-synthase (CBS), which converts Hcy to cystathionine.	Homocysteine	44-47	cystathionine beta-synthase	Homo sapiens	70-97
19787977-5	2005	Furthermore, the CCSD(T)/CBS calculations predict the existence of two BCl3+ transitional structures with D3h and C2v symmetries lying 800 and 1300 cm(-1), respectively, above the BCl3+ (X 2B2) ground state.	D3H	106-109	cystathionine beta-synthase	Homo sapiens	25-28
19787977-5	2005	Furthermore, the CCSD(T)/CBS calculations predict the existence of two BCl3+ transitional structures with D3h and C2v symmetries lying 800 and 1300 cm(-1), respectively, above the BCl3+ (X 2B2) ground state.	N-[2-(dimethylamino)ethyl]-3-[6-(thiophen-2-yl)imidazo[1,2-b]pyridazin-3-yl]benzamide	114-117	cystathionine beta-synthase	Homo sapiens	25-28
15581573-1	2005	Cystathionine beta-synthase in mammals lies at a pivotal crossroad in methionine metabolism directing flux toward cysteine synthesis and catabolism.	Methionine	70-80	cystathionine beta-synthase	Homo sapiens	0-27
15581573-1	2005	Cystathionine beta-synthase in mammals lies at a pivotal crossroad in methionine metabolism directing flux toward cysteine synthesis and catabolism.	Cysteine	114-122	cystathionine beta-synthase	Homo sapiens	0-27
15581573-8	2005	Studies with mammalian cells in culture as well as with animal models have unraveled multiple layers of regulation of cystathionine beta-synthase in response to redox perturbations and reveal the important role of this enzyme in glutathione-dependent redox homestasis.	Glutathione	229-240	cystathionine beta-synthase	Homo sapiens	118-145
15642325-2	2004	We examined the presence of the gene for cystathionine-beta-synthase (CBS), the rate limiting enzyme that converts homocysteine to cystathionine in the transsulfuration pathway, in human lens epithelial (HLE) B3 cells using PCR with primers designed based on the sequence of human liver CBS (Forward 5"-CCA CAC TGC CCC GGC AAA AT-3"; Reverse 5"-CTG GCA ATG CCC GTG ATG GT-3").	Homocysteine	115-127	cystathionine beta-synthase	Homo sapiens	41-68
15520012-0	2004	Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.	Cysteine	92-100	cystathionine beta-synthase	Homo sapiens	40-67
15520012-0	2004	Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.	Homocysteine	105-117	cystathionine beta-synthase	Homo sapiens	40-67
15520012-3	2004	Reactions catalyzed by the cystathionine beta-synthase enzyme (CBS) are one possible source for the production of H2S.	Hydrogen Sulfide	114-117	cystathionine beta-synthase	Homo sapiens	27-54
15520012-3	2004	Reactions catalyzed by the cystathionine beta-synthase enzyme (CBS) are one possible source for the production of H2S.	Hydrogen Sulfide	114-117	cystathionine beta-synthase	Homo sapiens	63-66
15520012-4	2004	Here we show that the CBS enzyme can efficiently produce H2S via a beta-replacement reaction in which cysteine is condensed with homocysteine to form cystathionine and H2S.	Hydrogen Sulfide	57-60	cystathionine beta-synthase	Homo sapiens	22-25
15520012-4	2004	Here we show that the CBS enzyme can efficiently produce H2S via a beta-replacement reaction in which cysteine is condensed with homocysteine to form cystathionine and H2S.	Cysteine	102-110	cystathionine beta-synthase	Homo sapiens	22-25
15520012-4	2004	Here we show that the CBS enzyme can efficiently produce H2S via a beta-replacement reaction in which cysteine is condensed with homocysteine to form cystathionine and H2S.	Homocysteine	129-141	cystathionine beta-synthase	Homo sapiens	22-25
15520012-4	2004	Here we show that the CBS enzyme can efficiently produce H2S via a beta-replacement reaction in which cysteine is condensed with homocysteine to form cystathionine and H2S.	Cystathionine	150-163	cystathionine beta-synthase	Homo sapiens	22-25
15520012-4	2004	Here we show that the CBS enzyme can efficiently produce H2S via a beta-replacement reaction in which cysteine is condensed with homocysteine to form cystathionine and H2S.	Hydrogen Sulfide	168-171	cystathionine beta-synthase	Homo sapiens	22-25
15520012-9	2004	In summary, these results confirm the ability of CBS to produce H2S, but show in contrast to prior reports that the major mechanism is via beta-replacement and not cysteine hydrolysis.	Hydrogen Sulfide	64-67	cystathionine beta-synthase	Homo sapiens	49-52
15520012-0	2004	Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.	Hydrogen Sulfide	33-36	cystathionine beta-synthase	Homo sapiens	40-67
15642325-2	2004	We examined the presence of the gene for cystathionine-beta-synthase (CBS), the rate limiting enzyme that converts homocysteine to cystathionine in the transsulfuration pathway, in human lens epithelial (HLE) B3 cells using PCR with primers designed based on the sequence of human liver CBS (Forward 5"-CCA CAC TGC CCC GGC AAA AT-3"; Reverse 5"-CTG GCA ATG CCC GTG ATG GT-3").	Homocysteine	115-127	cystathionine beta-synthase	Homo sapiens	70-73
15642325-2	2004	We examined the presence of the gene for cystathionine-beta-synthase (CBS), the rate limiting enzyme that converts homocysteine to cystathionine in the transsulfuration pathway, in human lens epithelial (HLE) B3 cells using PCR with primers designed based on the sequence of human liver CBS (Forward 5"-CCA CAC TGC CCC GGC AAA AT-3"; Reverse 5"-CTG GCA ATG CCC GTG ATG GT-3").	Cystathionine	41-54	cystathionine beta-synthase	Homo sapiens	70-73
15642325-7	2004	Oxidative stress transiently upregulated the gene expression of CBS both in HLE cells (0.1 mMH2O2) and in pig lens cultured in TC 199 medium (0.5 mMH2O2).	tc 199 medium	127-140	cystathionine beta-synthase	Homo sapiens	64-67
15642325-8	2004	The catalytic activity for CBS, which was assayed by measuring the production of C14-cystathionine from C14-serine in the presence of homocysteine, S-adenosyl-methionine and pyridoxal phosphate, was detectable in the HLE cells and transiently activated with H2O2.	c14-cystathionine	81-98	cystathionine beta-synthase	Homo sapiens	27-30
15642325-8	2004	The catalytic activity for CBS, which was assayed by measuring the production of C14-cystathionine from C14-serine in the presence of homocysteine, S-adenosyl-methionine and pyridoxal phosphate, was detectable in the HLE cells and transiently activated with H2O2.	c14-serine	104-114	cystathionine beta-synthase	Homo sapiens	27-30
15642325-8	2004	The catalytic activity for CBS, which was assayed by measuring the production of C14-cystathionine from C14-serine in the presence of homocysteine, S-adenosyl-methionine and pyridoxal phosphate, was detectable in the HLE cells and transiently activated with H2O2.	Homocysteine	134-146	cystathionine beta-synthase	Homo sapiens	27-30
15642325-8	2004	The catalytic activity for CBS, which was assayed by measuring the production of C14-cystathionine from C14-serine in the presence of homocysteine, S-adenosyl-methionine and pyridoxal phosphate, was detectable in the HLE cells and transiently activated with H2O2.	S-Adenosylmethionine	148-169	cystathionine beta-synthase	Homo sapiens	27-30
15642325-8	2004	The catalytic activity for CBS, which was assayed by measuring the production of C14-cystathionine from C14-serine in the presence of homocysteine, S-adenosyl-methionine and pyridoxal phosphate, was detectable in the HLE cells and transiently activated with H2O2.	Pyridoxal Phosphate	174-193	cystathionine beta-synthase	Homo sapiens	27-30
15642325-8	2004	The catalytic activity for CBS, which was assayed by measuring the production of C14-cystathionine from C14-serine in the presence of homocysteine, S-adenosyl-methionine and pyridoxal phosphate, was detectable in the HLE cells and transiently activated with H2O2.	Hydrogen Peroxide	258-262	cystathionine beta-synthase	Homo sapiens	27-30
15642325-11	2004	We have shown that oxidative stress of H2O2 could increase the flux of this transsulfuration pathway by committing more homocysteine to cysteine and glutathione production as H2O2 (0.1 mM) inhibited the remethylation enzyme of methionine synthase while concurrently activating the CBS enzyme.	Hydrogen Peroxide	39-43	cystathionine beta-synthase	Homo sapiens	281-284
15642325-11	2004	We have shown that oxidative stress of H2O2 could increase the flux of this transsulfuration pathway by committing more homocysteine to cysteine and glutathione production as H2O2 (0.1 mM) inhibited the remethylation enzyme of methionine synthase while concurrently activating the CBS enzyme.	Homocysteine	120-132	cystathionine beta-synthase	Homo sapiens	281-284
15642325-11	2004	We have shown that oxidative stress of H2O2 could increase the flux of this transsulfuration pathway by committing more homocysteine to cysteine and glutathione production as H2O2 (0.1 mM) inhibited the remethylation enzyme of methionine synthase while concurrently activating the CBS enzyme.	Cysteine	124-132	cystathionine beta-synthase	Homo sapiens	281-284
15642325-11	2004	We have shown that oxidative stress of H2O2 could increase the flux of this transsulfuration pathway by committing more homocysteine to cysteine and glutathione production as H2O2 (0.1 mM) inhibited the remethylation enzyme of methionine synthase while concurrently activating the CBS enzyme.	Glutathione	149-160	cystathionine beta-synthase	Homo sapiens	281-284
15642325-11	2004	We have shown that oxidative stress of H2O2 could increase the flux of this transsulfuration pathway by committing more homocysteine to cysteine and glutathione production as H2O2 (0.1 mM) inhibited the remethylation enzyme of methionine synthase while concurrently activating the CBS enzyme.	Hydrogen Peroxide	175-179	cystathionine beta-synthase	Homo sapiens	281-284
15544339-0	2004	The redox behavior of the heme in cystathionine beta-synthase is sensitive to pH.	Heme	26-30	cystathionine beta-synthase	Homo sapiens	34-61
15544339-1	2004	Human cystathionine beta-synthase (CBS) is a unique pyridoxal-5"-phosphate-dependent enzyme in which heme is also present as a cofactor.	Pyridoxal Phosphate	52-74	cystathionine beta-synthase	Homo sapiens	6-33
15544339-1	2004	Human cystathionine beta-synthase (CBS) is a unique pyridoxal-5"-phosphate-dependent enzyme in which heme is also present as a cofactor.	Pyridoxal Phosphate	52-74	cystathionine beta-synthase	Homo sapiens	35-38
15544339-1	2004	Human cystathionine beta-synthase (CBS) is a unique pyridoxal-5"-phosphate-dependent enzyme in which heme is also present as a cofactor.	Heme	101-105	cystathionine beta-synthase	Homo sapiens	6-33
15544339-1	2004	Human cystathionine beta-synthase (CBS) is a unique pyridoxal-5"-phosphate-dependent enzyme in which heme is also present as a cofactor.	Heme	101-105	cystathionine beta-synthase	Homo sapiens	35-38
15544339-2	2004	Because the function of heme in this enzyme has yet to be elucidated, the study presented herein investigated possible relationships between the chemistry of the heme and the strong pH dependence of CBS activity.	Heme	162-166	cystathionine beta-synthase	Homo sapiens	199-202
15544339-5	2004	Instead, pH was found to control the equilibrium amount of ferric and ferrous heme present after reaction of CBS with one-electron reducing agents.	Ferric enterobactin ion	59-65	cystathionine beta-synthase	Homo sapiens	109-112
15544339-5	2004	Instead, pH was found to control the equilibrium amount of ferric and ferrous heme present after reaction of CBS with one-electron reducing agents.	ferrous heme	70-82	cystathionine beta-synthase	Homo sapiens	109-112
15544339-6	2004	A variety of spectroscopic techniques, including resonance Raman, magnetic circular dichroism, and electron paramagnetic resonance, demonstrated that at pH 9 Fe(II) CBS is dominant while at pH 6 Fe(III) CBS is favored.	ammonium ferrous sulfate	158-164	cystathionine beta-synthase	Homo sapiens	165-168
15544339-6	2004	A variety of spectroscopic techniques, including resonance Raman, magnetic circular dichroism, and electron paramagnetic resonance, demonstrated that at pH 9 Fe(II) CBS is dominant while at pH 6 Fe(III) CBS is favored.	ferric sulfate	195-202	cystathionine beta-synthase	Homo sapiens	203-206
15544339-7	2004	At low pH, Fe(II) CBS forms transiently but reoxidizes by an apparent proton-gated electron-transfer mechanism.	ammonium ferrous sulfate	11-17	cystathionine beta-synthase	Homo sapiens	18-21
15544339-8	2004	Regulation of CBS activity by the iron redox state has been proposed as the role of the heme moiety in this enzyme.	Iron	34-38	cystathionine beta-synthase	Homo sapiens	14-17
15544339-8	2004	Regulation of CBS activity by the iron redox state has been proposed as the role of the heme moiety in this enzyme.	Heme	88-92	cystathionine beta-synthase	Homo sapiens	14-17
15365998-0	2004	The cystathionine beta-synthase (CBS) mutation c.1224-2A&gt;C in Central Europe: Vitamin B6 nonresponsiveness and a common ancestral haplotype.	Vitamin B 6	81-91	cystathionine beta-synthase	Homo sapiens	4-31
15365998-0	2004	The cystathionine beta-synthase (CBS) mutation c.1224-2A&gt;C in Central Europe: Vitamin B6 nonresponsiveness and a common ancestral haplotype.	Vitamin B 6	81-91	cystathionine beta-synthase	Homo sapiens	33-36
15365998-7	2004	In summary, the data of this study suggest that the CBS c.1224-2A&gt;C allele confers vitamin B6 nonresponsiveness and that this mutant allele came from a common ancestor.	Vitamin B 6	86-96	cystathionine beta-synthase	Homo sapiens	52-55
15196993-0	2004	Visualization of PLP-bound intermediates in hemeless variants of human cystathionine beta-synthase: evidence that lysine 119 is a general base.	Lysine	114-120	cystathionine beta-synthase	Homo sapiens	71-98
15497768-2	2004	Recent studies demonstrate a role of the transsulfuration enzymes, cystathionine gamma-lyase and cystathionine beta-synthase, in catalyzing the desulfhydration of cysteine in brain and smooth muscle.	Cysteine	163-171	cystathionine beta-synthase	Homo sapiens	97-124
15497768-4	2004	In glutamatergic neurons, the production of H2S by cystathionine beta-synthase enhances N-methyl-D-aspartate (NMDA) receptor-mediated currents.	Hydrogen Sulfide	44-47	cystathionine beta-synthase	Homo sapiens	51-78
15280798-2	2004	H2S is synthesized from L-cysteine by either cystathionine beta-synthase (CBS) or cystathionin gamma--lyase (CSE), both using pyridoxal 5"-phosphate (vitamin B6) as a cofactor.	Deuterium	0-3	cystathionine beta-synthase	Homo sapiens	45-72
15280798-2	2004	H2S is synthesized from L-cysteine by either cystathionine beta-synthase (CBS) or cystathionin gamma--lyase (CSE), both using pyridoxal 5"-phosphate (vitamin B6) as a cofactor.	Cysteine	24-34	cystathionine beta-synthase	Homo sapiens	45-72
15280798-2	2004	H2S is synthesized from L-cysteine by either cystathionine beta-synthase (CBS) or cystathionin gamma--lyase (CSE), both using pyridoxal 5"-phosphate (vitamin B6) as a cofactor.	Pyridoxal Phosphate	126-148	cystathionine beta-synthase	Homo sapiens	45-72
15280798-2	2004	H2S is synthesized from L-cysteine by either cystathionine beta-synthase (CBS) or cystathionin gamma--lyase (CSE), both using pyridoxal 5"-phosphate (vitamin B6) as a cofactor.	Vitamin B 6	150-160	cystathionine beta-synthase	Homo sapiens	45-72
15196993-1	2004	Cystathionine beta-synthase catalyzes the condensation of serine and homocysteine to give cystathionine in a pyridoxal phosphate (PLP)-dependent reaction.	Serine	58-64	cystathionine beta-synthase	Homo sapiens	0-27
15196993-1	2004	Cystathionine beta-synthase catalyzes the condensation of serine and homocysteine to give cystathionine in a pyridoxal phosphate (PLP)-dependent reaction.	Homocysteine	69-81	cystathionine beta-synthase	Homo sapiens	0-27
15196993-1	2004	Cystathionine beta-synthase catalyzes the condensation of serine and homocysteine to give cystathionine in a pyridoxal phosphate (PLP)-dependent reaction.	Cystathionine	90-103	cystathionine beta-synthase	Homo sapiens	0-27
15196993-1	2004	Cystathionine beta-synthase catalyzes the condensation of serine and homocysteine to give cystathionine in a pyridoxal phosphate (PLP)-dependent reaction.	Pyridoxal Phosphate	109-128	cystathionine beta-synthase	Homo sapiens	0-27
15196993-1	2004	Cystathionine beta-synthase catalyzes the condensation of serine and homocysteine to give cystathionine in a pyridoxal phosphate (PLP)-dependent reaction.	Pyridoxal Phosphate	130-133	cystathionine beta-synthase	Homo sapiens	0-27
15196993-12	2004	These results are consistent with an additional role for K119 as a general base in the reaction catalyzed by human cystathionine beta-synthase.	1,2-bis(methylsulfonyl)-1--(2-chloroethyl)-2-((1-(4-nitrophenyl)ethoxy)carbonyl)hydrazine	57-61	cystathionine beta-synthase	Homo sapiens	115-142
15329822-1	2004	The formation of H2S from cyst(e)ine is catalyzed by three enzymes, cystathionine beta synthase, cystathionase, and 3-mercaptopyruvate sulfurtransferase.	Hydrogen Sulfide	17-20	cystathionine beta-synthase	Homo sapiens	68-95
15329822-1	2004	The formation of H2S from cyst(e)ine is catalyzed by three enzymes, cystathionine beta synthase, cystathionase, and 3-mercaptopyruvate sulfurtransferase.	(e)ine	30-36	cystathionine beta-synthase	Homo sapiens	68-95
15329822-9	2004	The concentration of H2S is abnormally low in the brains of subjects with Alzheimer"s disease, due to changes in the concentration of the physiological activator of cystathionine beta synthase.	Hydrogen Sulfide	21-24	cystathionine beta-synthase	Homo sapiens	165-192
15329822-10	2004	The overproduction of H2S described in subjects with Down"s syndrome probably results from the overproduction of cystathionine beta synthase, as the gene encoding this protein is located on chromosome 21.	Hydrogen Sulfide	22-25	cystathionine beta-synthase	Homo sapiens	113-140
15181872-2	2004	The majority of Hcy undergoes transsulfuration to cysteine by cystathionine beta-synthase (CBS), of which vitamin B6 (pyridoxine) is an essential cofactor.	Homocysteine	16-19	cystathionine beta-synthase	Homo sapiens	62-89
15134582-7	2004	The absence of the cystathionine beta synthase enzyme in human vascular cells contributes to the importance of a dual role of folic acid in lowering tHcy through remethylation, as well as, its action of being an electron and hydrogen donor to the essential cofactor tetrahydrobiopterin.	Folic Acid	126-136	cystathionine beta-synthase	Homo sapiens	19-46
15134582-7	2004	The absence of the cystathionine beta synthase enzyme in human vascular cells contributes to the importance of a dual role of folic acid in lowering tHcy through remethylation, as well as, its action of being an electron and hydrogen donor to the essential cofactor tetrahydrobiopterin.	thcy	149-153	cystathionine beta-synthase	Homo sapiens	19-46
15134582-7	2004	The absence of the cystathionine beta synthase enzyme in human vascular cells contributes to the importance of a dual role of folic acid in lowering tHcy through remethylation, as well as, its action of being an electron and hydrogen donor to the essential cofactor tetrahydrobiopterin.	Hydrogen	225-233	cystathionine beta-synthase	Homo sapiens	19-46
15134582-7	2004	The absence of the cystathionine beta synthase enzyme in human vascular cells contributes to the importance of a dual role of folic acid in lowering tHcy through remethylation, as well as, its action of being an electron and hydrogen donor to the essential cofactor tetrahydrobiopterin.	sapropterin	266-285	cystathionine beta-synthase	Homo sapiens	19-46
15975077-2	2004	The latter may result from mutations of the genes coding for three key enzymes involved in homocysteine metabolism (methylenetetrahydrofolate reductase [MTHFR], methionine synthase [MS], and cystathionine beta-synthase [CBS]).	Homocysteine	91-103	cystathionine beta-synthase	Homo sapiens	191-218
15975077-2	2004	The latter may result from mutations of the genes coding for three key enzymes involved in homocysteine metabolism (methylenetetrahydrofolate reductase [MTHFR], methionine synthase [MS], and cystathionine beta-synthase [CBS]).	Homocysteine	91-103	cystathionine beta-synthase	Homo sapiens	220-223
15975077-4	2004	In order to evaluate whether AD is associated with CBS gene changes leading to decreased CBS activity and homocysteine accumulation, we genotyped the CBS 844ins68 mutation and VNTR polymorphisms of the CBS gene in 206 AD patients and 186 age-matched controls.	Homocysteine	106-118	cystathionine beta-synthase	Homo sapiens	51-54
15181872-2	2004	The majority of Hcy undergoes transsulfuration to cysteine by cystathionine beta-synthase (CBS), of which vitamin B6 (pyridoxine) is an essential cofactor.	Cysteine	50-58	cystathionine beta-synthase	Homo sapiens	62-89
15181872-2	2004	The majority of Hcy undergoes transsulfuration to cysteine by cystathionine beta-synthase (CBS), of which vitamin B6 (pyridoxine) is an essential cofactor.	Vitamin B 6	106-116	cystathionine beta-synthase	Homo sapiens	62-89
15181872-2	2004	The majority of Hcy undergoes transsulfuration to cysteine by cystathionine beta-synthase (CBS), of which vitamin B6 (pyridoxine) is an essential cofactor.	Pyridoxine	118-128	cystathionine beta-synthase	Homo sapiens	62-89
14670973-1	2004	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and transsulfuration.	Serine	64-70	cystathionine beta-synthase	Homo sapiens	0-27
14670973-1	2004	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and transsulfuration.	Homocysteine	76-88	cystathionine beta-synthase	Homo sapiens	0-27
14670973-1	2004	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and transsulfuration.	Cystathionine	97-110	cystathionine beta-synthase	Homo sapiens	0-27
14670973-1	2004	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and transsulfuration.	Methionine	166-176	cystathionine beta-synthase	Homo sapiens	0-27
14744791-5	2004	In clinically relevant AML cell line models, high cystathionine-beta-synthase transcripts in DS CMK cells were accompanied by 10-fold greater ara-C sensitivity and 2.4-fold higher levels of ara-CTP compared with non-DS CMS cells.	Cytarabine	142-147	cystathionine beta-synthase	Homo sapiens	50-77
14722927-3	2004	We developed a new antisense oligonucleotide (ASO) PCR/hybridization method to screen for 12 of the most frequent CBS mutations in 14 unrelated patients from the UK and 38 unrelated patients from the US, a total of 104 independent alleles.	Oligonucleotides, Antisense	46-49	cystathionine beta-synthase	Homo sapiens	114-117
14978683-2	2004	Because the protein Huntingtin interacts with the homocysteine metabolism modulating enzyme cystathionine beta-synthase, we hypothesize that homocysteine promotes neurodegeneration in HD.	Homocysteine	50-62	cystathionine beta-synthase	Homo sapiens	92-119
14978683-2	2004	Because the protein Huntingtin interacts with the homocysteine metabolism modulating enzyme cystathionine beta-synthase, we hypothesize that homocysteine promotes neurodegeneration in HD.	Homocysteine	141-153	cystathionine beta-synthase	Homo sapiens	92-119
15017331-1	2004	PURPOSE: For treatment of cystathionine beta-synthase (CbetaS) deficiency, we determined the effect of betaine (N,N,N-trimethylglycine) therapy and examined the genotype-phenotype relationships to betaine.	Betaine	103-110	cystathionine beta-synthase	Homo sapiens	55-61
14744791-5	2004	In clinically relevant AML cell line models, high cystathionine-beta-synthase transcripts in DS CMK cells were accompanied by 10-fold greater ara-C sensitivity and 2.4-fold higher levels of ara-CTP compared with non-DS CMS cells.	ara-ctp	190-197	cystathionine beta-synthase	Homo sapiens	50-77
14722619-5	2004	We now show that tandem pairs of CBS domains from AMP-activated protein kinase, IMP dehydrogenase-2, the chloride channel CLC2, and cystathionine beta-synthase bind AMP, ATP, or S-adenosyl methionine,while mutations that cause hereditary diseases impair this binding.	Adenosine Monophosphate	50-53	cystathionine beta-synthase	Homo sapiens	132-159
14722619-5	2004	We now show that tandem pairs of CBS domains from AMP-activated protein kinase, IMP dehydrogenase-2, the chloride channel CLC2, and cystathionine beta-synthase bind AMP, ATP, or S-adenosyl methionine,while mutations that cause hereditary diseases impair this binding.	Adenosine Triphosphate	170-173	cystathionine beta-synthase	Homo sapiens	132-159
14722619-5	2004	We now show that tandem pairs of CBS domains from AMP-activated protein kinase, IMP dehydrogenase-2, the chloride channel CLC2, and cystathionine beta-synthase bind AMP, ATP, or S-adenosyl methionine,while mutations that cause hereditary diseases impair this binding.	Methionine	189-199	cystathionine beta-synthase	Homo sapiens	132-159
15354395-2	2004	This protein interacts with the homocysteine metabolizing enzyme cystathionine betasynthase (CBS).	Homocysteine	32-44	cystathionine beta-synthase	Homo sapiens	65-91
12615917-1	2003	Cystathionine beta-synthase (CBS) catalyzes the first of two steps in the transsulfuration pathway that converts homocysteine to cysteine, a precursor of glutathione, a major intracellular antioxidant.	Homocysteine	113-125	cystathionine beta-synthase	Homo sapiens	0-27
12822833-1	2003	Homocystinuria is an inherited metabolic disease characterized biochemically by increased blood and brain levels of homocysteine caused by severe deficiency of cystathionine beta-synthase activity.	Homocysteine	116-128	cystathionine beta-synthase	Homo sapiens	160-187
12670934-1	2003	Vitamins B12, B6, and folic acid converge at the homocysteine metabolic junction where they support the activities of two key enzymes involved in intracellular homocysteine management, methionine synthase (MS) and cystathionine beta-synthase.	B6	14-16	cystathionine beta-synthase	Homo sapiens	214-241
12670934-1	2003	Vitamins B12, B6, and folic acid converge at the homocysteine metabolic junction where they support the activities of two key enzymes involved in intracellular homocysteine management, methionine synthase (MS) and cystathionine beta-synthase.	Folic Acid	22-32	cystathionine beta-synthase	Homo sapiens	214-241
12670934-1	2003	Vitamins B12, B6, and folic acid converge at the homocysteine metabolic junction where they support the activities of two key enzymes involved in intracellular homocysteine management, methionine synthase (MS) and cystathionine beta-synthase.	Homocysteine	49-61	cystathionine beta-synthase	Homo sapiens	214-241
12670934-1	2003	Vitamins B12, B6, and folic acid converge at the homocysteine metabolic junction where they support the activities of two key enzymes involved in intracellular homocysteine management, methionine synthase (MS) and cystathionine beta-synthase.	Homocysteine	160-172	cystathionine beta-synthase	Homo sapiens	214-241
12615917-1	2003	Cystathionine beta-synthase (CBS) catalyzes the first of two steps in the transsulfuration pathway that converts homocysteine to cysteine, a precursor of glutathione, a major intracellular antioxidant.	Homocysteine	113-125	cystathionine beta-synthase	Homo sapiens	29-32
12615917-1	2003	Cystathionine beta-synthase (CBS) catalyzes the first of two steps in the transsulfuration pathway that converts homocysteine to cysteine, a precursor of glutathione, a major intracellular antioxidant.	Cysteine	117-125	cystathionine beta-synthase	Homo sapiens	0-27
12615917-1	2003	Cystathionine beta-synthase (CBS) catalyzes the first of two steps in the transsulfuration pathway that converts homocysteine to cysteine, a precursor of glutathione, a major intracellular antioxidant.	Cysteine	117-125	cystathionine beta-synthase	Homo sapiens	29-32
12615917-1	2003	Cystathionine beta-synthase (CBS) catalyzes the first of two steps in the transsulfuration pathway that converts homocysteine to cysteine, a precursor of glutathione, a major intracellular antioxidant.	Glutathione	154-165	cystathionine beta-synthase	Homo sapiens	0-27
12615917-1	2003	Cystathionine beta-synthase (CBS) catalyzes the first of two steps in the transsulfuration pathway that converts homocysteine to cysteine, a precursor of glutathione, a major intracellular antioxidant.	Glutathione	154-165	cystathionine beta-synthase	Homo sapiens	29-32
12686104-1	2003	In mammals, cystathionine beta-synthase catalyzes the first step in the transsulfuration pathway which provides an avenue for the conversion of the essential amino acid, methionine, to cysteine.	Amino Acids, Essential	148-168	cystathionine beta-synthase	Homo sapiens	12-39
12686104-1	2003	In mammals, cystathionine beta-synthase catalyzes the first step in the transsulfuration pathway which provides an avenue for the conversion of the essential amino acid, methionine, to cysteine.	Methionine	170-180	cystathionine beta-synthase	Homo sapiens	12-39
12686134-1	2003	Cystathionine beta-synthase (CBS) is a unique heme-containing enzyme that catalyses a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Pyridoxal Phosphate	86-108	cystathionine beta-synthase	Homo sapiens	0-27
12686134-1	2003	Cystathionine beta-synthase (CBS) is a unique heme-containing enzyme that catalyses a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Pyridoxal Phosphate	86-108	cystathionine beta-synthase	Homo sapiens	29-32
12397075-8	2002	These findings suggest that the CBS domains play an important role in AMP-binding within the complex.	Adenosine Monophosphate	70-73	cystathionine beta-synthase	Homo sapiens	32-35
12686134-1	2003	Cystathionine beta-synthase (CBS) is a unique heme-containing enzyme that catalyses a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Pyridoxal Phosphate	110-113	cystathionine beta-synthase	Homo sapiens	0-27
12686134-1	2003	Cystathionine beta-synthase (CBS) is a unique heme-containing enzyme that catalyses a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Pyridoxal Phosphate	110-113	cystathionine beta-synthase	Homo sapiens	29-32
12686134-1	2003	Cystathionine beta-synthase (CBS) is a unique heme-containing enzyme that catalyses a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Serine	141-147	cystathionine beta-synthase	Homo sapiens	0-27
12686134-1	2003	Cystathionine beta-synthase (CBS) is a unique heme-containing enzyme that catalyses a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Serine	141-147	cystathionine beta-synthase	Homo sapiens	29-32
12686134-1	2003	Cystathionine beta-synthase (CBS) is a unique heme-containing enzyme that catalyses a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Homocysteine	152-164	cystathionine beta-synthase	Homo sapiens	0-27
12686134-1	2003	Cystathionine beta-synthase (CBS) is a unique heme-containing enzyme that catalyses a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Homocysteine	152-164	cystathionine beta-synthase	Homo sapiens	29-32
12686134-1	2003	Cystathionine beta-synthase (CBS) is a unique heme-containing enzyme that catalyses a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Cystathionine	173-186	cystathionine beta-synthase	Homo sapiens	0-27
12686134-1	2003	Cystathionine beta-synthase (CBS) is a unique heme-containing enzyme that catalyses a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Cystathionine	173-186	cystathionine beta-synthase	Homo sapiens	29-32
12795447-2	2003	Recent studies have demonstrated that under diabetic conditions, the catabolism of homocysteine was enhanced by transcriptional regulation of hepatic cystathionine beta-synthase and these changes were prevented by treatment with insulin.	Homocysteine	83-95	cystathionine beta-synthase	Homo sapiens	150-177
12649066-0	2003	Gene-gene interaction between the cystathionine beta-synthase 31 base pair variable number of tandem repeats and the methylenetetrahydrofolate reductase 677C &gt; T polymorphism on homocysteine levels and risk for neural tube defects.	Homocysteine	181-193	cystathionine beta-synthase	Homo sapiens	34-61
12801808-5	2003	The two pathways are coordinated by S-adenosylmethionine which acts as an allosteric inhibitor of the methylenetetrahydrofolate reductase (MTHFR) and as an activator of cystathionine beta-synthase (CBS).	S-Adenosylmethionine	36-56	cystathionine beta-synthase	Homo sapiens	169-196
12631446-2	2003	The latter condenses homocysteine and serine to cystathionine in a reaction catalyzed by cystathionine beta-synthase followed by cleavage of cystathionine to cysteine and alpha-ketoglutarate by gamma-cystathionase.	Homocysteine	21-33	cystathionine beta-synthase	Homo sapiens	89-116
12631446-2	2003	The latter condenses homocysteine and serine to cystathionine in a reaction catalyzed by cystathionine beta-synthase followed by cleavage of cystathionine to cysteine and alpha-ketoglutarate by gamma-cystathionase.	Serine	38-44	cystathionine beta-synthase	Homo sapiens	89-116
12631446-2	2003	The latter condenses homocysteine and serine to cystathionine in a reaction catalyzed by cystathionine beta-synthase followed by cleavage of cystathionine to cysteine and alpha-ketoglutarate by gamma-cystathionase.	Cystathionine	48-61	cystathionine beta-synthase	Homo sapiens	89-116
12631446-2	2003	The latter condenses homocysteine and serine to cystathionine in a reaction catalyzed by cystathionine beta-synthase followed by cleavage of cystathionine to cysteine and alpha-ketoglutarate by gamma-cystathionase.	Cysteine	25-33	cystathionine beta-synthase	Homo sapiens	89-116
12631446-2	2003	The latter condenses homocysteine and serine to cystathionine in a reaction catalyzed by cystathionine beta-synthase followed by cleavage of cystathionine to cysteine and alpha-ketoglutarate by gamma-cystathionase.	Ketoglutaric Acids	171-190	cystathionine beta-synthase	Homo sapiens	89-116
12686104-1	2003	In mammals, cystathionine beta-synthase catalyzes the first step in the transsulfuration pathway which provides an avenue for the conversion of the essential amino acid, methionine, to cysteine.	Cysteine	185-193	cystathionine beta-synthase	Homo sapiens	12-39
12686104-2	2003	Cystathionine beta-synthase catalyzes a PLP-dependent condensation of serine and homocysteine to cystathionine and is unique in also having a heme cofactor.	Serine	70-76	cystathionine beta-synthase	Homo sapiens	0-27
12686104-2	2003	Cystathionine beta-synthase catalyzes a PLP-dependent condensation of serine and homocysteine to cystathionine and is unique in also having a heme cofactor.	Homocysteine	81-93	cystathionine beta-synthase	Homo sapiens	0-27
12686104-2	2003	Cystathionine beta-synthase catalyzes a PLP-dependent condensation of serine and homocysteine to cystathionine and is unique in also having a heme cofactor.	Cystathionine	97-110	cystathionine beta-synthase	Homo sapiens	0-27
12686104-2	2003	Cystathionine beta-synthase catalyzes a PLP-dependent condensation of serine and homocysteine to cystathionine and is unique in also having a heme cofactor.	Heme	142-146	cystathionine beta-synthase	Homo sapiens	0-27
12529702-2	2003	The only way of homocysteine degradation is conversion to cysteine in the transsulfuration pathway in which the regulating step is catalysed by cystathionine beta-synthase (CBS).	Cysteine	20-28	cystathionine beta-synthase	Homo sapiens	144-171
12529702-2	2003	The only way of homocysteine degradation is conversion to cysteine in the transsulfuration pathway in which the regulating step is catalysed by cystathionine beta-synthase (CBS).	Cysteine	20-28	cystathionine beta-synthase	Homo sapiens	173-176
12379655-2	2002	Cystathionine beta-synthase is a tetrameric hemeprotein that catalyzes the pyridoxal 5"-phosphate-dependent condensation of serine and homocysteine to cystathionine.	Pyridoxal Phosphate	75-97	cystathionine beta-synthase	Homo sapiens	0-27
12427542-1	2002	Cystathionine-beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine.	Serine	64-70	cystathionine beta-synthase	Homo sapiens	0-27
12427542-1	2002	Cystathionine-beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine.	Homocysteine	75-87	cystathionine beta-synthase	Homo sapiens	0-27
12427542-1	2002	Cystathionine-beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine.	Cystathionine	96-109	cystathionine beta-synthase	Homo sapiens	0-27
12379655-2	2002	Cystathionine beta-synthase is a tetrameric hemeprotein that catalyzes the pyridoxal 5"-phosphate-dependent condensation of serine and homocysteine to cystathionine.	Serine	124-130	cystathionine beta-synthase	Homo sapiens	0-27
12427542-1	2002	Cystathionine-beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine.	Cysteine	79-87	cystathionine beta-synthase	Homo sapiens	0-27
12379655-2	2002	Cystathionine beta-synthase is a tetrameric hemeprotein that catalyzes the pyridoxal 5"-phosphate-dependent condensation of serine and homocysteine to cystathionine.	Homocysteine	135-147	cystathionine beta-synthase	Homo sapiens	0-27
12379655-2	2002	Cystathionine beta-synthase is a tetrameric hemeprotein that catalyzes the pyridoxal 5"-phosphate-dependent condensation of serine and homocysteine to cystathionine.	Cystathionine	151-164	cystathionine beta-synthase	Homo sapiens	0-27
12173932-0	2002	Human cystathionine beta-synthase is a heme sensor protein.	Heme	39-43	cystathionine beta-synthase	Homo sapiens	6-33
12269827-1	2002	Human cystathionine beta-synthase is a heme protein that catalyzes the condensation of serine and homocysteine to form cystathionine in a pyridoxal phosphate-dependent reaction.	Serine	87-93	cystathionine beta-synthase	Homo sapiens	6-33
12269827-1	2002	Human cystathionine beta-synthase is a heme protein that catalyzes the condensation of serine and homocysteine to form cystathionine in a pyridoxal phosphate-dependent reaction.	Homocysteine	98-110	cystathionine beta-synthase	Homo sapiens	6-33
12269827-1	2002	Human cystathionine beta-synthase is a heme protein that catalyzes the condensation of serine and homocysteine to form cystathionine in a pyridoxal phosphate-dependent reaction.	Pyridoxal Phosphate	138-157	cystathionine beta-synthase	Homo sapiens	6-33
12271675-1	2002	Serine-O-carbonate derivatives, including peptides having a serine-O-carbonate residue at the N-terminal position, are catalytically transformed into S-substituted cysteine derivatives employing the pyridoxal model having an ionophore function in the presence of Li+; this is the first artificial model mimicking cystathionine Beta-synthase.	serine-o-carbonate	0-18	cystathionine beta-synthase	Homo sapiens	313-340
12271675-1	2002	Serine-O-carbonate derivatives, including peptides having a serine-O-carbonate residue at the N-terminal position, are catalytically transformed into S-substituted cysteine derivatives employing the pyridoxal model having an ionophore function in the presence of Li+; this is the first artificial model mimicking cystathionine Beta-synthase.	Peptides	42-50	cystathionine beta-synthase	Homo sapiens	313-340
12271675-1	2002	Serine-O-carbonate derivatives, including peptides having a serine-O-carbonate residue at the N-terminal position, are catalytically transformed into S-substituted cysteine derivatives employing the pyridoxal model having an ionophore function in the presence of Li+; this is the first artificial model mimicking cystathionine Beta-synthase.	serine-o-carbonate	60-78	cystathionine beta-synthase	Homo sapiens	313-340
12271675-1	2002	Serine-O-carbonate derivatives, including peptides having a serine-O-carbonate residue at the N-terminal position, are catalytically transformed into S-substituted cysteine derivatives employing the pyridoxal model having an ionophore function in the presence of Li+; this is the first artificial model mimicking cystathionine Beta-synthase.	s-substituted cysteine	150-172	cystathionine beta-synthase	Homo sapiens	313-340
12271675-1	2002	Serine-O-carbonate derivatives, including peptides having a serine-O-carbonate residue at the N-terminal position, are catalytically transformed into S-substituted cysteine derivatives employing the pyridoxal model having an ionophore function in the presence of Li+; this is the first artificial model mimicking cystathionine Beta-synthase.	Pyridoxal	199-208	cystathionine beta-synthase	Homo sapiens	313-340
12173932-3	2002	The only route for the catabolic removal of homocysteine in mammals begins with the pyridoxal phosphate- (PLP-) dependent beta-replacement reaction catalyzed by cystathionine beta-synthase.	Homocysteine	44-56	cystathionine beta-synthase	Homo sapiens	161-188
12173932-3	2002	The only route for the catabolic removal of homocysteine in mammals begins with the pyridoxal phosphate- (PLP-) dependent beta-replacement reaction catalyzed by cystathionine beta-synthase.	Pyridoxal Phosphate	84-103	cystathionine beta-synthase	Homo sapiens	161-188
12115739-1	2002	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Cystathionine	97-110	cystathionine beta-synthase	Homo sapiens	0-27
12145770-1	2002	Abnormal elevation of plasma methionine may result from several different genetic abnormalities, including deficiency of cystathionine beta-synthase (CBS) or of the isoenzymes of methionine adenosyltransferase (MAT) I and III expressed solely in nonfetal liver (MAT I/III deficiency).	Methionine	29-39	cystathionine beta-synthase	Homo sapiens	121-148
12145770-1	2002	Abnormal elevation of plasma methionine may result from several different genetic abnormalities, including deficiency of cystathionine beta-synthase (CBS) or of the isoenzymes of methionine adenosyltransferase (MAT) I and III expressed solely in nonfetal liver (MAT I/III deficiency).	Methionine	29-39	cystathionine beta-synthase	Homo sapiens	150-153
12115739-1	2002	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Serine	64-70	cystathionine beta-synthase	Homo sapiens	0-27
12392053-5	2002	This discovery accelerated the identification of an H2S-producing enzyme, cystathionine beta-synthase (CBS) in the brain.	Hydrogen Sulfide	52-55	cystathionine beta-synthase	Homo sapiens	74-101
12115739-1	2002	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Serine	64-70	cystathionine beta-synthase	Homo sapiens	29-32
12115739-1	2002	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Cystathionine	97-110	cystathionine beta-synthase	Homo sapiens	29-32
12115739-1	2002	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Homocysteine	76-88	cystathionine beta-synthase	Homo sapiens	0-27
12115739-1	2002	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Methionine	166-176	cystathionine beta-synthase	Homo sapiens	0-27
12115739-1	2002	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Homocysteine	76-88	cystathionine beta-synthase	Homo sapiens	29-32
12115739-1	2002	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Methionine	166-176	cystathionine beta-synthase	Homo sapiens	29-32
12115739-1	2002	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Cysteine	80-88	cystathionine beta-synthase	Homo sapiens	0-27
12115739-1	2002	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine with homocysteine to form cystathionine and occupies a crucial regulatory position between the methionine cycle and the biosynthesis of cysteine by transsulfuration.	Cysteine	80-88	cystathionine beta-synthase	Homo sapiens	29-32
12115739-3	2002	In batch cultures of Saccharomyces cerevisiae, maximal CBS activities were observed in the exponential phase of cells grown on glucose, while growth-arrested cultures or those growing non-fermentatively on ethanol or glycerol had approximately 3-fold less activity.	Glucose	127-134	cystathionine beta-synthase	Homo sapiens	55-58
12115739-3	2002	In batch cultures of Saccharomyces cerevisiae, maximal CBS activities were observed in the exponential phase of cells grown on glucose, while growth-arrested cultures or those growing non-fermentatively on ethanol or glycerol had approximately 3-fold less activity.	Ethanol	206-213	cystathionine beta-synthase	Homo sapiens	55-58
12115739-3	2002	In batch cultures of Saccharomyces cerevisiae, maximal CBS activities were observed in the exponential phase of cells grown on glucose, while growth-arrested cultures or those growing non-fermentatively on ethanol or glycerol had approximately 3-fold less activity.	Glycerol	217-225	cystathionine beta-synthase	Homo sapiens	55-58
12115739-8	2002	The intracellular level of the CBS regulator compound, S-adenosylmethionine, was found to reflect the proliferation status of both yeast and human cells, and as such, constitutes an additional mechanism for proliferation-specific regulation of human CBS.	S-Adenosylmethionine	55-75	cystathionine beta-synthase	Homo sapiens	31-34
12115739-8	2002	The intracellular level of the CBS regulator compound, S-adenosylmethionine, was found to reflect the proliferation status of both yeast and human cells, and as such, constitutes an additional mechanism for proliferation-specific regulation of human CBS.	S-Adenosylmethionine	55-75	cystathionine beta-synthase	Homo sapiens	250-253
11889073-3	2002	The cystathionine beta-synthase (CBS) enzyme reduces homocysteine levels and thus may protect against CRC.	Homocysteine	53-65	cystathionine beta-synthase	Homo sapiens	4-31
12007221-0	2002	High homocysteine and thrombosis without connective tissue disorders are associated with a novel class of cystathionine beta-synthase (CBS) mutations.	Homocysteine	5-17	cystathionine beta-synthase	Homo sapiens	135-138
12007221-1	2002	Cystathionine beta-synthase (CBS) is a crucial regulator of plasma levels of the thrombogenic amino acid homocysteine (Hcy).	amino acid homocysteine	94-117	cystathionine beta-synthase	Homo sapiens	0-27
12007221-1	2002	Cystathionine beta-synthase (CBS) is a crucial regulator of plasma levels of the thrombogenic amino acid homocysteine (Hcy).	amino acid homocysteine	94-117	cystathionine beta-synthase	Homo sapiens	29-32
12007221-1	2002	Cystathionine beta-synthase (CBS) is a crucial regulator of plasma levels of the thrombogenic amino acid homocysteine (Hcy).	Homocysteine	119-122	cystathionine beta-synthase	Homo sapiens	0-27
12007221-1	2002	Cystathionine beta-synthase (CBS) is a crucial regulator of plasma levels of the thrombogenic amino acid homocysteine (Hcy).	Homocysteine	119-122	cystathionine beta-synthase	Homo sapiens	29-32
12007221-5	2002	We describe a novel class of missense mutations consisting of I435T, P422L, and S466L that are located in the non-catalytic C-terminal region of CBS that yield enzymes that are catalytically active but deficient in their response to S-adenosylmethionine (AdoMet).	S-Adenosylmethionine	233-253	cystathionine beta-synthase	Homo sapiens	145-148
12007221-5	2002	We describe a novel class of missense mutations consisting of I435T, P422L, and S466L that are located in the non-catalytic C-terminal region of CBS that yield enzymes that are catalytically active but deficient in their response to S-adenosylmethionine (AdoMet).	S-Adenosylmethionine	255-261	cystathionine beta-synthase	Homo sapiens	145-148
12027183-1	2002	This paper presents results of measurements of short (0.3 ps, 0.2 ns, and 10 ns) laser pulse transmissions through a liquid suspension of fine carbon particles (named CBS for "carbon-black suspension") at input-pulse energies up to 10 mJ.	Carbon	143-149	cystathionine beta-synthase	Homo sapiens	167-170
12027183-1	2002	This paper presents results of measurements of short (0.3 ps, 0.2 ns, and 10 ns) laser pulse transmissions through a liquid suspension of fine carbon particles (named CBS for "carbon-black suspension") at input-pulse energies up to 10 mJ.	Carbon	176-182	cystathionine beta-synthase	Homo sapiens	167-170
12186157-3	2002	Our study was aimed at finding the relationship between HCA, folate, vitamins B12 levels, and mutations in the 5,10-methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS) genes.	Folic Acid	61-67	cystathionine beta-synthase	Homo sapiens	164-191
12007221-0	2002	High homocysteine and thrombosis without connective tissue disorders are associated with a novel class of cystathionine beta-synthase (CBS) mutations.	Homocysteine	5-17	cystathionine beta-synthase	Homo sapiens	106-133
12054683-1	2002	Although hydrogen sulfide (H2S) is generally thought of in terms of a poisonous gas, it is endogenously produced in the brain from cysteine by cystathionine beta-synthase (CBS).	Hydrogen Sulfide	9-25	cystathionine beta-synthase	Homo sapiens	143-170
12054683-1	2002	Although hydrogen sulfide (H2S) is generally thought of in terms of a poisonous gas, it is endogenously produced in the brain from cysteine by cystathionine beta-synthase (CBS).	Hydrogen Sulfide	9-25	cystathionine beta-synthase	Homo sapiens	172-175
12054683-1	2002	Although hydrogen sulfide (H2S) is generally thought of in terms of a poisonous gas, it is endogenously produced in the brain from cysteine by cystathionine beta-synthase (CBS).	Deuterium	27-30	cystathionine beta-synthase	Homo sapiens	143-170
12054683-1	2002	Although hydrogen sulfide (H2S) is generally thought of in terms of a poisonous gas, it is endogenously produced in the brain from cysteine by cystathionine beta-synthase (CBS).	Deuterium	27-30	cystathionine beta-synthase	Homo sapiens	172-175
12054683-1	2002	Although hydrogen sulfide (H2S) is generally thought of in terms of a poisonous gas, it is endogenously produced in the brain from cysteine by cystathionine beta-synthase (CBS).	Cysteine	131-139	cystathionine beta-synthase	Homo sapiens	143-170
12054683-1	2002	Although hydrogen sulfide (H2S) is generally thought of in terms of a poisonous gas, it is endogenously produced in the brain from cysteine by cystathionine beta-synthase (CBS).	Cysteine	131-139	cystathionine beta-synthase	Homo sapiens	172-175
12054683-4	2002	In addition to H2S production CBS also catalyzes another metabolic pathway in which cystathionine is produced from the substrate homocysteine.	Deuterium	15-18	cystathionine beta-synthase	Homo sapiens	30-33
12054683-4	2002	In addition to H2S production CBS also catalyzes another metabolic pathway in which cystathionine is produced from the substrate homocysteine.	Cystathionine	84-97	cystathionine beta-synthase	Homo sapiens	30-33
12054683-4	2002	In addition to H2S production CBS also catalyzes another metabolic pathway in which cystathionine is produced from the substrate homocysteine.	Homocysteine	129-141	cystathionine beta-synthase	Homo sapiens	30-33
12054683-5	2002	Previous findings, which showed that S-adenosyl-l-methionine (SAM), a CBS activator, is much reduced in AD brain and that homocysteine accumulates in the serum of AD patients, were confirmed.	S-Adenosylmethionine	37-60	cystathionine beta-synthase	Homo sapiens	70-73
12054683-5	2002	Previous findings, which showed that S-adenosyl-l-methionine (SAM), a CBS activator, is much reduced in AD brain and that homocysteine accumulates in the serum of AD patients, were confirmed.	S-Adenosylmethionine	62-65	cystathionine beta-synthase	Homo sapiens	70-73
11926827-0	2002	Effects of heme ligand mutations including a pathogenic variant, H65R, on the properties of human cystathionine beta-synthase.	Heme	11-15	cystathionine beta-synthase	Homo sapiens	98-125
11926827-1	2002	Human cystathionine beta-synthase is a hemeprotein that catalyzes a pyridoxal phosphate (PLP)-dependent condensation of serine and homocysteine into cystathionine.	Pyridoxal Phosphate	68-87	cystathionine beta-synthase	Homo sapiens	6-33
11926827-1	2002	Human cystathionine beta-synthase is a hemeprotein that catalyzes a pyridoxal phosphate (PLP)-dependent condensation of serine and homocysteine into cystathionine.	Pyridoxal Phosphate	89-92	cystathionine beta-synthase	Homo sapiens	6-33
11926827-1	2002	Human cystathionine beta-synthase is a hemeprotein that catalyzes a pyridoxal phosphate (PLP)-dependent condensation of serine and homocysteine into cystathionine.	Serine	120-126	cystathionine beta-synthase	Homo sapiens	6-33
11926827-1	2002	Human cystathionine beta-synthase is a hemeprotein that catalyzes a pyridoxal phosphate (PLP)-dependent condensation of serine and homocysteine into cystathionine.	Homocysteine	131-143	cystathionine beta-synthase	Homo sapiens	6-33
11889073-3	2002	The cystathionine beta-synthase (CBS) enzyme reduces homocysteine levels and thus may protect against CRC.	Homocysteine	53-65	cystathionine beta-synthase	Homo sapiens	33-36
11857551-0	2002	Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient with cystathionine beta-synthase (CBS) deficiency.	Methionine	48-58	cystathionine beta-synthase	Homo sapiens	104-131
11857551-0	2002	Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient with cystathionine beta-synthase (CBS) deficiency.	Betaine	70-77	cystathionine beta-synthase	Homo sapiens	104-131
11562358-1	2001	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine.	Serine	64-70	cystathionine beta-synthase	Homo sapiens	0-27
11744062-0	2001	Characterization of NO binding to human cystathionine beta-synthase: possible implications of the effects of CO and NO binding to the human enzyme.	Carbon Monoxide	109-111	cystathionine beta-synthase	Homo sapiens	40-67
11744062-1	2001	Homocysteine is a key junction metabolite that can be converted to cystathionine in a reaction catalyzed by the heme and pyridoxal phosphate-dependent cystathionine beta-synthase.	Homocysteine	0-12	cystathionine beta-synthase	Homo sapiens	151-178
11744062-1	2001	Homocysteine is a key junction metabolite that can be converted to cystathionine in a reaction catalyzed by the heme and pyridoxal phosphate-dependent cystathionine beta-synthase.	Cystathionine	67-80	cystathionine beta-synthase	Homo sapiens	151-178
11744062-9	2001	These studies demonstrate that as with CO, perturbation of the heme environment by NO is communicated to the active site with concomitant inhibition of enzyme activity, and suggests a regulatory role for heme in cystathionine beta-synthase.	Heme	63-67	cystathionine beta-synthase	Homo sapiens	212-239
11744062-9	2001	These studies demonstrate that as with CO, perturbation of the heme environment by NO is communicated to the active site with concomitant inhibition of enzyme activity, and suggests a regulatory role for heme in cystathionine beta-synthase.	Heme	204-208	cystathionine beta-synthase	Homo sapiens	212-239
11744063-0	2001	Mercuric chloride-induced spin or ligation state changes in ferric or ferrous human cystathionine beta-synthase inhibit enzyme activity.	Mercuric Chloride	0-17	cystathionine beta-synthase	Homo sapiens	84-111
11744063-1	2001	Cystathionine beta-synthase is a key heme and pyridoxal phosphate-dependent enzyme involved in homocysteine metabolism in humans.	Heme	37-41	cystathionine beta-synthase	Homo sapiens	0-27
11744063-1	2001	Cystathionine beta-synthase is a key heme and pyridoxal phosphate-dependent enzyme involved in homocysteine metabolism in humans.	Pyridoxal Phosphate	46-65	cystathionine beta-synthase	Homo sapiens	0-27
11562358-1	2001	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine.	Homocysteine	75-87	cystathionine beta-synthase	Homo sapiens	0-27
11562358-1	2001	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine.	Cystathionine	96-109	cystathionine beta-synthase	Homo sapiens	0-27
11562358-1	2001	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine.	Cysteine	79-87	cystathionine beta-synthase	Homo sapiens	0-27
11672761-1	2001	The mutations in homocysteine (Hcy) metabolism-related enzyme genes including methylenetetrahydrofolate reductase (MTHFR) C677T, cystathionine beta-synthase (CBS) 844ins68, and methionine synthase (MS) A2756G have been identified as genetic risk factors for thromboembolic events.	Homocysteine	31-34	cystathionine beta-synthase	Homo sapiens	129-156
11568918-7	2001	In addition, the child had a five-fold increase in cystathionine level relative to normal children, consistent with over-expression of the cystathionine beta synthase gene present on chromosome 21.	Cystathionine	51-64	cystathionine beta-synthase	Homo sapiens	139-166
11528503-0	2001	A 31 bp VNTR in the cystathionine beta-synthase (CBS) gene is associated with reduced CBS activity and elevated post-load homocysteine levels.	Homocysteine	122-134	cystathionine beta-synthase	Homo sapiens	49-52
11583707-7	2001	In contrast CBS activity increased from 0.017 to 0.13 U/ml by increasing the glucose concentration in the medium (P&lt;0.01), but decreased from 0.04 to 0.02 (P&lt;0.01) when the insulin concentration was increased from 5 to 200 mU/ml, respectively.	Glucose	77-84	cystathionine beta-synthase	Homo sapiens	12-15
11528503-0	2001	A 31 bp VNTR in the cystathionine beta-synthase (CBS) gene is associated with reduced CBS activity and elevated post-load homocysteine levels.	Homocysteine	122-134	cystathionine beta-synthase	Homo sapiens	20-47
11524006-0	2001	Regulation of human cystathionine beta-synthase by S-adenosyl-L-methionine: evidence for two catalytically active conformations involving an autoinhibitory domain in the C-terminal region.	S-Adenosylmethionine	51-74	cystathionine beta-synthase	Homo sapiens	20-47
11524006-1	2001	Cystathionine beta-synthase (CBS), condensing homocysteine and serine, represents a key regulatory point in the biosynthesis of cysteine via the transsulfuration pathway.	Homocysteine	46-58	cystathionine beta-synthase	Homo sapiens	0-27
11524006-1	2001	Cystathionine beta-synthase (CBS), condensing homocysteine and serine, represents a key regulatory point in the biosynthesis of cysteine via the transsulfuration pathway.	Homocysteine	46-58	cystathionine beta-synthase	Homo sapiens	29-32
11524006-1	2001	Cystathionine beta-synthase (CBS), condensing homocysteine and serine, represents a key regulatory point in the biosynthesis of cysteine via the transsulfuration pathway.	Serine	63-69	cystathionine beta-synthase	Homo sapiens	0-27
11524006-1	2001	Cystathionine beta-synthase (CBS), condensing homocysteine and serine, represents a key regulatory point in the biosynthesis of cysteine via the transsulfuration pathway.	Serine	63-69	cystathionine beta-synthase	Homo sapiens	29-32
11524006-1	2001	Cystathionine beta-synthase (CBS), condensing homocysteine and serine, represents a key regulatory point in the biosynthesis of cysteine via the transsulfuration pathway.	Cysteine	50-58	cystathionine beta-synthase	Homo sapiens	0-27
11524006-1	2001	Cystathionine beta-synthase (CBS), condensing homocysteine and serine, represents a key regulatory point in the biosynthesis of cysteine via the transsulfuration pathway.	Cysteine	50-58	cystathionine beta-synthase	Homo sapiens	29-32
11524006-3	2001	CBS is activated by S-adenosyl-L-methionine (AdoMet) by inducing a conformational change involving a noncatalytic C-terminal region spanning residues 414-551.	S-Adenosylmethionine	20-43	cystathionine beta-synthase	Homo sapiens	0-3
11524006-3	2001	CBS is activated by S-adenosyl-L-methionine (AdoMet) by inducing a conformational change involving a noncatalytic C-terminal region spanning residues 414-551.	S-Adenosylmethionine	45-51	cystathionine beta-synthase	Homo sapiens	0-3
11524006-10	2001	Tryptophan and PLP fluorescence data for these different forms of CBS indicate that activation by AdoMet, limited proteolysis, and thermal denaturation share a common mechanism involving the displacement of an autoinhibitory domain located in the C-terminal region of the protein.	Tryptophan	0-10	cystathionine beta-synthase	Homo sapiens	66-69
11483494-0	2001	Structure of human cystathionine beta-synthase: a unique pyridoxal 5"-phosphate-dependent heme protein.	Pyridoxal Phosphate	57-79	cystathionine beta-synthase	Homo sapiens	19-46
11483494-1	2001	Cystathionine beta-synthase (CBS) is a unique heme- containing enzyme that catalyzes a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Heme	46-50	cystathionine beta-synthase	Homo sapiens	0-27
11483494-1	2001	Cystathionine beta-synthase (CBS) is a unique heme- containing enzyme that catalyzes a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Heme	46-50	cystathionine beta-synthase	Homo sapiens	29-32
11483494-1	2001	Cystathionine beta-synthase (CBS) is a unique heme- containing enzyme that catalyzes a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Pyridoxal Phosphate	87-109	cystathionine beta-synthase	Homo sapiens	0-27
11483494-1	2001	Cystathionine beta-synthase (CBS) is a unique heme- containing enzyme that catalyzes a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Pyridoxal Phosphate	87-109	cystathionine beta-synthase	Homo sapiens	29-32
11483494-1	2001	Cystathionine beta-synthase (CBS) is a unique heme- containing enzyme that catalyzes a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Serine	142-148	cystathionine beta-synthase	Homo sapiens	0-27
11483494-1	2001	Cystathionine beta-synthase (CBS) is a unique heme- containing enzyme that catalyzes a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Serine	142-148	cystathionine beta-synthase	Homo sapiens	29-32
11483494-1	2001	Cystathionine beta-synthase (CBS) is a unique heme- containing enzyme that catalyzes a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Homocysteine	153-165	cystathionine beta-synthase	Homo sapiens	0-27
11483494-1	2001	Cystathionine beta-synthase (CBS) is a unique heme- containing enzyme that catalyzes a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Homocysteine	153-165	cystathionine beta-synthase	Homo sapiens	29-32
11483494-1	2001	Cystathionine beta-synthase (CBS) is a unique heme- containing enzyme that catalyzes a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Cystathionine	174-187	cystathionine beta-synthase	Homo sapiens	0-27
11483494-1	2001	Cystathionine beta-synthase (CBS) is a unique heme- containing enzyme that catalyzes a pyridoxal 5"-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine.	Cystathionine	174-187	cystathionine beta-synthase	Homo sapiens	29-32
11483494-4	2001	CBS shares the same fold with O-acetylserine sulfhydrylase but it contains an additional N-terminal heme binding site.	Heme	100-104	cystathionine beta-synthase	Homo sapiens	0-3
11528503-3	2001	We assessed the association between a 31 bp VNTR, that spans the exon 13-intron 13 boundary of the CBS gene, and fasting, post-methionine load and increase upon methionine load plasma homocysteine levels in 190 patients with arterial occlusive disease, and in 381 controls.	Methionine	127-137	cystathionine beta-synthase	Homo sapiens	99-102
11528503-3	2001	We assessed the association between a 31 bp VNTR, that spans the exon 13-intron 13 boundary of the CBS gene, and fasting, post-methionine load and increase upon methionine load plasma homocysteine levels in 190 patients with arterial occlusive disease, and in 381 controls.	Methionine	161-171	cystathionine beta-synthase	Homo sapiens	99-102
11528503-3	2001	We assessed the association between a 31 bp VNTR, that spans the exon 13-intron 13 boundary of the CBS gene, and fasting, post-methionine load and increase upon methionine load plasma homocysteine levels in 190 patients with arterial occlusive disease, and in 381 controls.	Homocysteine	184-196	cystathionine beta-synthase	Homo sapiens	99-102
11528503-8	2001	The 31 bp VNTR in the CBS gene is associated with post-methionine load hyperhomocysteinaemia that may predispose individuals to an increased risk of cardiovascular diseases.	Methionine	55-65	cystathionine beta-synthase	Homo sapiens	22-25
11457468-2	2001	Molecular studies have demonstrated increased plasma homocysteine levels in the presence of DNA mutations in either the methylenetetrahydrofolate reductase (MTHFR) enzyme found in the remethylation pathway or the enzyme cystathione beta-synthase (CBS) of the transsulfuration pathway.	Homocysteine	53-65	cystathionine beta-synthase	Homo sapiens	220-245
11596649-4	2001	Plasma sarcosine (N-methylglycine) is elevated, together with elevated plasma AdoMet in normal subjects following oral methionine loads and in association with increased plasma levels of both methionine and AdoMet in cystathionine beta-synthase-deficient individuals.	Sarcosine	7-16	cystathionine beta-synthase	Homo sapiens	217-244
11596649-4	2001	Plasma sarcosine (N-methylglycine) is elevated, together with elevated plasma AdoMet in normal subjects following oral methionine loads and in association with increased plasma levels of both methionine and AdoMet in cystathionine beta-synthase-deficient individuals.	Sarcosine	18-33	cystathionine beta-synthase	Homo sapiens	217-244
11457468-2	2001	Molecular studies have demonstrated increased plasma homocysteine levels in the presence of DNA mutations in either the methylenetetrahydrofolate reductase (MTHFR) enzyme found in the remethylation pathway or the enzyme cystathione beta-synthase (CBS) of the transsulfuration pathway.	Homocysteine	53-65	cystathionine beta-synthase	Homo sapiens	247-250
11042162-11	2001	Finally, in the presence of homocysteine the alpha-aminoacrylate-enzyme absorption band readily disappears with the concomitant formation of the absorption band of the internal aldimine, indicating that cystathionine beta-synthase crystals catalyze both beta-elimination and beta-replacement reactions.	aldimine	177-185	cystathionine beta-synthase	Homo sapiens	203-230
11391481-10	2001	The increased activity of CBS in children with DS significantly alters homocysteine metabolism such that the folate-dependent resynthesis of methionine is compromised.	Folic Acid	109-115	cystathionine beta-synthase	Homo sapiens	26-29
11391481-10	2001	The increased activity of CBS in children with DS significantly alters homocysteine metabolism such that the folate-dependent resynthesis of methionine is compromised.	Methionine	141-151	cystathionine beta-synthase	Homo sapiens	26-29
11415440-1	2001	Cystathionine beta-synthase (CBS) catalyses the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine.	Serine	64-70	cystathionine beta-synthase	Homo sapiens	0-27
11415440-1	2001	Cystathionine beta-synthase (CBS) catalyses the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine.	Serine	64-70	cystathionine beta-synthase	Homo sapiens	29-32
11415440-1	2001	Cystathionine beta-synthase (CBS) catalyses the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine.	Homocysteine	75-87	cystathionine beta-synthase	Homo sapiens	0-27
11415440-1	2001	Cystathionine beta-synthase (CBS) catalyses the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine.	Homocysteine	75-87	cystathionine beta-synthase	Homo sapiens	29-32
11415440-1	2001	Cystathionine beta-synthase (CBS) catalyses the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine.	Cystathionine	96-109	cystathionine beta-synthase	Homo sapiens	0-27
11415440-1	2001	Cystathionine beta-synthase (CBS) catalyses the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine.	Cystathionine	96-109	cystathionine beta-synthase	Homo sapiens	29-32
11415440-1	2001	Cystathionine beta-synthase (CBS) catalyses the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine.	Cysteine	79-87	cystathionine beta-synthase	Homo sapiens	0-27
11415440-1	2001	Cystathionine beta-synthase (CBS) catalyses the condensation of serine and homocysteine to form cystathionine, an intermediate step in the synthesis of cysteine.	Cysteine	79-87	cystathionine beta-synthase	Homo sapiens	29-32
11230183-1	2001	Human cystathionine beta--synthase (CBS) is an S-adenosylmethionine-regulated enzyme that plays a key role in the metabolism of homocysteine.	Homocysteine	128-140	cystathionine beta-synthase	Homo sapiens	6-34
11230183-1	2001	Human cystathionine beta--synthase (CBS) is an S-adenosylmethionine-regulated enzyme that plays a key role in the metabolism of homocysteine.	Homocysteine	128-140	cystathionine beta-synthase	Homo sapiens	36-39
11148040-0	2001	Resonance Raman characterization of the heme cofactor in cystathionine beta-synthase.	Heme	40-44	cystathionine beta-synthase	Homo sapiens	57-84
11148040-2	2001	Human cystathionine beta-synthase (CBS) is an essential enzyme for the removal of the toxic metabolite homocysteine.	Homocysteine	103-115	cystathionine beta-synthase	Homo sapiens	6-33
11148040-2	2001	Human cystathionine beta-synthase (CBS) is an essential enzyme for the removal of the toxic metabolite homocysteine.	Homocysteine	103-115	cystathionine beta-synthase	Homo sapiens	35-38
11148040-5	2001	In this study, we have characterized the heme cofactor of CBS in both the ferric and ferrous states using resonance Raman spectroscopy.	Heme	41-45	cystathionine beta-synthase	Homo sapiens	58-61
11148040-5	2001	In this study, we have characterized the heme cofactor of CBS in both the ferric and ferrous states using resonance Raman spectroscopy.	Ferric enterobactin ion	74-80	cystathionine beta-synthase	Homo sapiens	58-61
11148040-7	2001	In addition, the CO adduct of ferrous CBS has vibrational frequencies characteristic of a histidine-heme-CO complex in a hydrophobic environment, and indicates that the Fe-S(Cys) bond is labile.	histidine-heme	90-104	cystathionine beta-synthase	Homo sapiens	38-41
11148040-7	2001	In addition, the CO adduct of ferrous CBS has vibrational frequencies characteristic of a histidine-heme-CO complex in a hydrophobic environment, and indicates that the Fe-S(Cys) bond is labile.	Carbon Monoxide	17-19	cystathionine beta-synthase	Homo sapiens	38-41
11148040-7	2001	In addition, the CO adduct of ferrous CBS has vibrational frequencies characteristic of a histidine-heme-CO complex in a hydrophobic environment, and indicates that the Fe-S(Cys) bond is labile.	Iron	169-173	cystathionine beta-synthase	Homo sapiens	38-41
11148040-7	2001	In addition, the CO adduct of ferrous CBS has vibrational frequencies characteristic of a histidine-heme-CO complex in a hydrophobic environment, and indicates that the Fe-S(Cys) bond is labile.	Cysteine	174-177	cystathionine beta-synthase	Homo sapiens	38-41
11042162-1	2001	Human cystathionine beta-synthase is a pyridoxal 5"-phosphate enzyme containing a heme binding domain and an S-adenosyl-l-methionine regulatory site.	Pyridoxal Phosphate	39-61	cystathionine beta-synthase	Homo sapiens	6-33
11042162-1	2001	Human cystathionine beta-synthase is a pyridoxal 5"-phosphate enzyme containing a heme binding domain and an S-adenosyl-l-methionine regulatory site.	Heme	82-86	cystathionine beta-synthase	Homo sapiens	6-33
11042162-1	2001	Human cystathionine beta-synthase is a pyridoxal 5"-phosphate enzyme containing a heme binding domain and an S-adenosyl-l-methionine regulatory site.	Sulfur	109-110	cystathionine beta-synthase	Homo sapiens	6-33
11042162-1	2001	Human cystathionine beta-synthase is a pyridoxal 5"-phosphate enzyme containing a heme binding domain and an S-adenosyl-l-methionine regulatory site.	S-Adenosylmethionine	111-132	cystathionine beta-synthase	Homo sapiens	6-33
11042162-11	2001	Finally, in the presence of homocysteine the alpha-aminoacrylate-enzyme absorption band readily disappears with the concomitant formation of the absorption band of the internal aldimine, indicating that cystathionine beta-synthase crystals catalyze both beta-elimination and beta-replacement reactions.	Homocysteine	28-40	cystathionine beta-synthase	Homo sapiens	203-230
11042162-11	2001	Finally, in the presence of homocysteine the alpha-aminoacrylate-enzyme absorption band readily disappears with the concomitant formation of the absorption band of the internal aldimine, indicating that cystathionine beta-synthase crystals catalyze both beta-elimination and beta-replacement reactions.	dehydroalanine	45-64	cystathionine beta-synthase	Homo sapiens	203-230
11481906-2	2001	Hyperhomocysteinemia may be induced by failure or decreased enzyme activity of the cystathionine-beta-synthase and methylenetetrahydrofolate reductase due to genetic mutation or deficiency of folic acid, vitamin B12 and vitamin B6.	Folic Acid	192-202	cystathionine beta-synthase	Homo sapiens	83-110
11481906-2	2001	Hyperhomocysteinemia may be induced by failure or decreased enzyme activity of the cystathionine-beta-synthase and methylenetetrahydrofolate reductase due to genetic mutation or deficiency of folic acid, vitamin B12 and vitamin B6.	Vitamin B 12	204-215	cystathionine beta-synthase	Homo sapiens	83-110
11481906-2	2001	Hyperhomocysteinemia may be induced by failure or decreased enzyme activity of the cystathionine-beta-synthase and methylenetetrahydrofolate reductase due to genetic mutation or deficiency of folic acid, vitamin B12 and vitamin B6.	Vitamin B 6	220-230	cystathionine beta-synthase	Homo sapiens	83-110
11327727-0	2001	Coordination chemistry of the heme in cystathionine beta-synthase: formation of iron(II)-isonitrile complexes.	Heme	30-34	cystathionine beta-synthase	Homo sapiens	38-65
11327727-0	2001	Coordination chemistry of the heme in cystathionine beta-synthase: formation of iron(II)-isonitrile complexes.	iron(ii)-isonitrile	80-99	cystathionine beta-synthase	Homo sapiens	38-65
11173483-1	2001	Cystathionine beta-synthase (CBS) is a unique heme enzyme that catalyzes a PLP-dependent condensation of serine and homocysteine to give cystathionine.	Serine	105-111	cystathionine beta-synthase	Homo sapiens	0-27
11173483-1	2001	Cystathionine beta-synthase (CBS) is a unique heme enzyme that catalyzes a PLP-dependent condensation of serine and homocysteine to give cystathionine.	Serine	105-111	cystathionine beta-synthase	Homo sapiens	29-32
11173483-1	2001	Cystathionine beta-synthase (CBS) is a unique heme enzyme that catalyzes a PLP-dependent condensation of serine and homocysteine to give cystathionine.	Homocysteine	116-128	cystathionine beta-synthase	Homo sapiens	0-27
11173483-1	2001	Cystathionine beta-synthase (CBS) is a unique heme enzyme that catalyzes a PLP-dependent condensation of serine and homocysteine to give cystathionine.	Homocysteine	116-128	cystathionine beta-synthase	Homo sapiens	29-32
11173483-1	2001	Cystathionine beta-synthase (CBS) is a unique heme enzyme that catalyzes a PLP-dependent condensation of serine and homocysteine to give cystathionine.	Cystathionine	137-150	cystathionine beta-synthase	Homo sapiens	0-27
11173483-1	2001	Cystathionine beta-synthase (CBS) is a unique heme enzyme that catalyzes a PLP-dependent condensation of serine and homocysteine to give cystathionine.	Cystathionine	137-150	cystathionine beta-synthase	Homo sapiens	29-32
11103808-2	2000	The cystathionine-beta-synthase (CBS) gene (localized to chromosome 21q22.3) may have downstream effects on reduced folate and S-adenosylmethionine pathways; ara-C metabolism and folate pools are linked by the known synergistic effect of sequential methotrexate and ara-C therapy.	Folic Acid	179-185	cystathionine beta-synthase	Homo sapiens	33-36
11204591-9	2001	This interaction between CBS genotype and MTHFR and MS genotype points to a key role of the CBS transulphuration pathway in the metabolism of homocysteine that may be particularly important as a compensatory mechanism in subjects with low dietary folate.	Homocysteine	142-154	cystathionine beta-synthase	Homo sapiens	92-95
11204591-9	2001	This interaction between CBS genotype and MTHFR and MS genotype points to a key role of the CBS transulphuration pathway in the metabolism of homocysteine that may be particularly important as a compensatory mechanism in subjects with low dietary folate.	Folic Acid	247-253	cystathionine beta-synthase	Homo sapiens	25-28
11204591-9	2001	This interaction between CBS genotype and MTHFR and MS genotype points to a key role of the CBS transulphuration pathway in the metabolism of homocysteine that may be particularly important as a compensatory mechanism in subjects with low dietary folate.	Folic Acid	247-253	cystathionine beta-synthase	Homo sapiens	92-95
11277950-2	2001	Moreover, Homocysteine (Hcy), an amino acid, is metabolized in the liver requiring folate, vitamin B6, vitamin B12, and the activity of enzymes, i.e. cystathionine-beta-synthase.	Homocysteine	10-22	cystathionine beta-synthase	Homo sapiens	150-177
11277950-2	2001	Moreover, Homocysteine (Hcy), an amino acid, is metabolized in the liver requiring folate, vitamin B6, vitamin B12, and the activity of enzymes, i.e. cystathionine-beta-synthase.	Homocysteine	24-27	cystathionine beta-synthase	Homo sapiens	150-177
11277950-11	2001	CONCLUSIONS: It is suggested that the elevated Hcy levels in patients after 45 days on Iso therapy could be due either to the "inhibition" of cystathionine-beta-synthase by the drug and/or their liver dysfunction.	Homocysteine	47-50	cystathionine beta-synthase	Homo sapiens	142-169
11204591-7	2001	While the raising effects of V222 and MS D919 homozygosity on homocysteine level were essentially additive, the homocysteine lowering effect associated with the CBS 68bp allele was seen most strongly in men homozygous for the V222 allele (MTHFR-CBS genotype interaction p = 0.03) and the D919 allele (MS-CBS interaction p = 0.09).	Homocysteine	112-124	cystathionine beta-synthase	Homo sapiens	161-164
11204591-9	2001	This interaction between CBS genotype and MTHFR and MS genotype points to a key role of the CBS transulphuration pathway in the metabolism of homocysteine that may be particularly important as a compensatory mechanism in subjects with low dietary folate.	Homocysteine	142-154	cystathionine beta-synthase	Homo sapiens	25-28
11186895-11	2000	The two other prevalent genotypes, 16/17 and 17/18, are associated with significantly decreased tHcy levels as compared to the 17/ 17 genotype, suggesting that the 16 and 18 repeats haplotype may be in linkage disequilibrium with regulatory elements which upregulate CBS gene transcription.	thcy	96-100	cystathionine beta-synthase	Homo sapiens	267-270
11149614-0	2000	Influence of 699C--&gt;T and 1080C--&gt;T polymorphisms of the cystathionine beta-synthase gene on plasma homocysteine levels.	Homocysteine	106-118	cystathionine beta-synthase	Homo sapiens	63-90
11149614-3	2000	We studied 1,055 individuals with respect to the effect of two silent polymorphisms, the 699C--&gt; T and the 1080C--&gt;T, of the cystathionine beta-synthase (CBS) gene on plasma tHcy levels.	thcy	180-184	cystathionine beta-synthase	Homo sapiens	160-163
11216902-2	2000	Main regulating enzymes of homocysteine (Hcy) metabolism are cystathionine beta-synthase (CBS), methionine synthase and methylenetetrahydrofolate reductase (MTHFR).	Homocysteine	27-39	cystathionine beta-synthase	Homo sapiens	61-88
11216902-2	2000	Main regulating enzymes of homocysteine (Hcy) metabolism are cystathionine beta-synthase (CBS), methionine synthase and methylenetetrahydrofolate reductase (MTHFR).	Homocysteine	27-39	cystathionine beta-synthase	Homo sapiens	90-93
11216902-2	2000	Main regulating enzymes of homocysteine (Hcy) metabolism are cystathionine beta-synthase (CBS), methionine synthase and methylenetetrahydrofolate reductase (MTHFR).	Homocysteine	41-44	cystathionine beta-synthase	Homo sapiens	61-88
11216902-2	2000	Main regulating enzymes of homocysteine (Hcy) metabolism are cystathionine beta-synthase (CBS), methionine synthase and methylenetetrahydrofolate reductase (MTHFR).	Homocysteine	41-44	cystathionine beta-synthase	Homo sapiens	90-93
11103808-0	2000	Cystathionine-beta-synthase cDNA transfection alters the sensitivity and metabolism of 1-beta-D-arabinofuranosylcytosine in CCRF-CEM leukemia cells in vitro and in vivo: a model of leukemia in Down syndrome.	Cytarabine	87-120	cystathionine beta-synthase	Homo sapiens	0-27
11103808-2	2000	The cystathionine-beta-synthase (CBS) gene (localized to chromosome 21q22.3) may have downstream effects on reduced folate and S-adenosylmethionine pathways; ara-C metabolism and folate pools are linked by the known synergistic effect of sequential methotrexate and ara-C therapy.	Folic Acid	116-122	cystathionine beta-synthase	Homo sapiens	4-31
11103808-2	2000	The cystathionine-beta-synthase (CBS) gene (localized to chromosome 21q22.3) may have downstream effects on reduced folate and S-adenosylmethionine pathways; ara-C metabolism and folate pools are linked by the known synergistic effect of sequential methotrexate and ara-C therapy.	Folic Acid	116-122	cystathionine beta-synthase	Homo sapiens	33-36
11103808-2	2000	The cystathionine-beta-synthase (CBS) gene (localized to chromosome 21q22.3) may have downstream effects on reduced folate and S-adenosylmethionine pathways; ara-C metabolism and folate pools are linked by the known synergistic effect of sequential methotrexate and ara-C therapy.	S-Adenosylmethionine	127-147	cystathionine beta-synthase	Homo sapiens	4-31
11103808-2	2000	The cystathionine-beta-synthase (CBS) gene (localized to chromosome 21q22.3) may have downstream effects on reduced folate and S-adenosylmethionine pathways; ara-C metabolism and folate pools are linked by the known synergistic effect of sequential methotrexate and ara-C therapy.	S-Adenosylmethionine	127-147	cystathionine beta-synthase	Homo sapiens	33-36
11103808-2	2000	The cystathionine-beta-synthase (CBS) gene (localized to chromosome 21q22.3) may have downstream effects on reduced folate and S-adenosylmethionine pathways; ara-C metabolism and folate pools are linked by the known synergistic effect of sequential methotrexate and ara-C therapy.	Folic Acid	179-185	cystathionine beta-synthase	Homo sapiens	4-31
11103808-2	2000	The cystathionine-beta-synthase (CBS) gene (localized to chromosome 21q22.3) may have downstream effects on reduced folate and S-adenosylmethionine pathways; ara-C metabolism and folate pools are linked by the known synergistic effect of sequential methotrexate and ara-C therapy.	Methotrexate	249-261	cystathionine beta-synthase	Homo sapiens	4-31
11103808-2	2000	The cystathionine-beta-synthase (CBS) gene (localized to chromosome 21q22.3) may have downstream effects on reduced folate and S-adenosylmethionine pathways; ara-C metabolism and folate pools are linked by the known synergistic effect of sequential methotrexate and ara-C therapy.	Methotrexate	249-261	cystathionine beta-synthase	Homo sapiens	33-36
11103808-2	2000	The cystathionine-beta-synthase (CBS) gene (localized to chromosome 21q22.3) may have downstream effects on reduced folate and S-adenosylmethionine pathways; ara-C metabolism and folate pools are linked by the known synergistic effect of sequential methotrexate and ara-C therapy.	Cytarabine	158-163	cystathionine beta-synthase	Homo sapiens	4-31
11103808-2	2000	The cystathionine-beta-synthase (CBS) gene (localized to chromosome 21q22.3) may have downstream effects on reduced folate and S-adenosylmethionine pathways; ara-C metabolism and folate pools are linked by the known synergistic effect of sequential methotrexate and ara-C therapy.	Cytarabine	158-163	cystathionine beta-synthase	Homo sapiens	33-36
11103808-3	2000	We have shown that relative CBS transcripts were significantly higher in DS compared with non-DS myeloblasts, and CBS transcript levels correlated with in vitro ara-C sensitivity (J. W. Taub et al., Blood, 94: 1393-1400, 1999).	Cytarabine	161-166	cystathionine beta-synthase	Homo sapiens	28-31
11103808-3	2000	We have shown that relative CBS transcripts were significantly higher in DS compared with non-DS myeloblasts, and CBS transcript levels correlated with in vitro ara-C sensitivity (J. W. Taub et al., Blood, 94: 1393-1400, 1999).	Cytarabine	161-166	cystathionine beta-synthase	Homo sapiens	114-117
11103808-5	2000	CBS-transfected cells were a median 15-fold more sensitive in vitro to ara-C compared with wild-type cells and generated 8.5-fold higher [3H]ara-C triphosphate levels after in vitro incubation with [3H]ara-C.	Cytarabine	71-76	cystathionine beta-synthase	Homo sapiens	0-3
11103808-5	2000	CBS-transfected cells were a median 15-fold more sensitive in vitro to ara-C compared with wild-type cells and generated 8.5-fold higher [3H]ara-C triphosphate levels after in vitro incubation with [3H]ara-C.	Tritium	138-140	cystathionine beta-synthase	Homo sapiens	0-3
11103808-5	2000	CBS-transfected cells were a median 15-fold more sensitive in vitro to ara-C compared with wild-type cells and generated 8.5-fold higher [3H]ara-C triphosphate levels after in vitro incubation with [3H]ara-C.	Ara-C triphosphate	141-159	cystathionine beta-synthase	Homo sapiens	0-3
11103808-5	2000	CBS-transfected cells were a median 15-fold more sensitive in vitro to ara-C compared with wild-type cells and generated 8.5-fold higher [3H]ara-C triphosphate levels after in vitro incubation with [3H]ara-C.	Tritium	199-201	cystathionine beta-synthase	Homo sapiens	0-3
11103808-5	2000	CBS-transfected cells were a median 15-fold more sensitive in vitro to ara-C compared with wild-type cells and generated 8.5-fold higher [3H]ara-C triphosphate levels after in vitro incubation with [3H]ara-C.	Cytarabine	141-146	cystathionine beta-synthase	Homo sapiens	0-3
11103808-10	2000	Collectively, these results suggest a posttranscriptional regulation of dCK in CBS-overexpressing cells that contributes to increased ara-C phosphorylation and drug activity.	Cytarabine	134-139	cystathionine beta-synthase	Homo sapiens	79-82
11103808-11	2000	Further elucidating the mechanisms of increased sensitivity of DS cells to ara-C related to the CBS gene may lead to the application of these novel approaches to acute myeloid leukemia therapy for non-DS patients.	Cytarabine	75-80	cystathionine beta-synthase	Homo sapiens	96-99
11051561-1	2000	Cystathionine beta-synthase [CBS; L-serine hydro-lyase (adding homocysteine), EC 4.2.1.22] catalyzes the first committed step of transsulfuration in both yeast and humans.	Homocysteine	63-75	cystathionine beta-synthase	Homo sapiens	29-32
11051561-2	2000	It has been established previously that human CBS is a hemeprotein but although the heme group appears to be essential for CBS activity, the exact function of the heme group is unknown.	Heme	55-59	cystathionine beta-synthase	Homo sapiens	46-49
11051561-2	2000	It has been established previously that human CBS is a hemeprotein but although the heme group appears to be essential for CBS activity, the exact function of the heme group is unknown.	Heme	84-88	cystathionine beta-synthase	Homo sapiens	46-49
11051561-2	2000	It has been established previously that human CBS is a hemeprotein but although the heme group appears to be essential for CBS activity, the exact function of the heme group is unknown.	Heme	84-88	cystathionine beta-synthase	Homo sapiens	123-126
11051561-3	2000	CBS activity is absent in heme deficient strains of Saccharomyces cerevisiae grown without heme supplementation.	Heme	26-30	cystathionine beta-synthase	Homo sapiens	0-3
11051561-4	2000	CBS activity can be restored by supplementing these strains with heme, implying that there is a heme requirement for yeast CBS.	Heme	65-69	cystathionine beta-synthase	Homo sapiens	0-3
11051561-4	2000	CBS activity can be restored by supplementing these strains with heme, implying that there is a heme requirement for yeast CBS.	Heme	65-69	cystathionine beta-synthase	Homo sapiens	123-126
11051561-4	2000	CBS activity can be restored by supplementing these strains with heme, implying that there is a heme requirement for yeast CBS.	Heme	96-100	cystathionine beta-synthase	Homo sapiens	0-3
11051561-4	2000	CBS activity can be restored by supplementing these strains with heme, implying that there is a heme requirement for yeast CBS.	Heme	96-100	cystathionine beta-synthase	Homo sapiens	123-126
10956045-0	2000	Characterization of the heme in human cystathionine beta-synthase by X-ray absorption and electron paramagnetic resonance spectroscopies.	Heme	24-28	cystathionine beta-synthase	Homo sapiens	38-65
10894832-2	2000	The four most common functional polymorphisms in genes involved in folate/homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MS) A2756G, and cystathionine beta-synthase (CBS) 844ins68.	Folic Acid	67-73	cystathionine beta-synthase	Homo sapiens	201-228
10956045-1	2000	Human cystathionine beta-synthase is one of two key enzymes involved in intracellular metabolism of homocysteine.	Homocysteine	100-112	cystathionine beta-synthase	Homo sapiens	6-33
10956045-6	2000	The heme Soret peak of ferric cystathionine beta-synthase is at 428 nm and shifts to approximately 395 nm upon addition of the thiol chelator, mercuric chloride.	Sulfhydryl Compounds	127-132	cystathionine beta-synthase	Homo sapiens	30-57
10956045-6	2000	The heme Soret peak of ferric cystathionine beta-synthase is at 428 nm and shifts to approximately 395 nm upon addition of the thiol chelator, mercuric chloride.	Mercuric Chloride	143-160	cystathionine beta-synthase	Homo sapiens	30-57
10956045-10	2000	The X-ray absorption data reveal that iron in ferric cystathionine beta-synthase is 6-coordinate, with 1 high-Z scatterer and 5 low-Z scatterers.	Iron	38-42	cystathionine beta-synthase	Homo sapiens	53-80
10956045-12	2000	Together, these data support assignment of the axial ligands as cysteinate and imidazole in ferric cystathionine beta-synthase.	cysteinate	64-74	cystathionine beta-synthase	Homo sapiens	99-126
10956045-12	2000	Together, these data support assignment of the axial ligands as cysteinate and imidazole in ferric cystathionine beta-synthase.	imidazole	79-88	cystathionine beta-synthase	Homo sapiens	99-126
10894832-2	2000	The four most common functional polymorphisms in genes involved in folate/homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MS) A2756G, and cystathionine beta-synthase (CBS) 844ins68.	Folic Acid	67-73	cystathionine beta-synthase	Homo sapiens	230-233
10444346-0	1999	Relation between plasma homocysteine concentration, the 844ins68 variant of the cystathionine beta-synthase gene, and pyridoxal-5"-phosphate concentration.	Homocysteine	24-36	cystathionine beta-synthase	Homo sapiens	80-107
10833331-0	2000	Polymorphisms in the CBS gene associated with decreased risk of coronary artery disease and increased responsiveness to total homocysteine lowering by folic acid.	Homocysteine	126-138	cystathionine beta-synthase	Homo sapiens	21-24
10833331-0	2000	Polymorphisms in the CBS gene associated with decreased risk of coronary artery disease and increased responsiveness to total homocysteine lowering by folic acid.	Folic Acid	151-161	cystathionine beta-synthase	Homo sapiens	21-24
10833331-4	2000	We found that two single nucleotide polymorphisms in the cystathionine beta synthase (CBS) gene, 699C --> T and 1080T --> C, are associated with decreased risk of CAD and increased responsiveness to the tHcy lowering effects of folic acid.	thcy	203-207	cystathionine beta-synthase	Homo sapiens	57-84
10833331-4	2000	We found that two single nucleotide polymorphisms in the cystathionine beta synthase (CBS) gene, 699C --> T and 1080T --> C, are associated with decreased risk of CAD and increased responsiveness to the tHcy lowering effects of folic acid.	thcy	203-207	cystathionine beta-synthase	Homo sapiens	86-89
10833331-4	2000	We found that two single nucleotide polymorphisms in the cystathionine beta synthase (CBS) gene, 699C --> T and 1080T --> C, are associated with decreased risk of CAD and increased responsiveness to the tHcy lowering effects of folic acid.	Folic Acid	228-238	cystathionine beta-synthase	Homo sapiens	57-84
10833331-4	2000	We found that two single nucleotide polymorphisms in the cystathionine beta synthase (CBS) gene, 699C --> T and 1080T --> C, are associated with decreased risk of CAD and increased responsiveness to the tHcy lowering effects of folic acid.	Folic Acid	228-238	cystathionine beta-synthase	Homo sapiens	86-89
11011851-0	2000	Vascular complications of severe hyperhomocysteinemia in patients with homocystinuria due to cystathionine beta-synthase deficiency: effects of homocysteine-lowering therapy.	Homocysteine	38-50	cystathionine beta-synthase	Homo sapiens	93-120
10529187-1	1999	Cystathionine beta-synthase is a unique heme protein that catalyzes a pyridoxal phosphate (or PLP)-dependent beta-replacement reaction.	Pyridoxal Phosphate	70-89	cystathionine beta-synthase	Homo sapiens	0-27
10758367-5	2000	In methylation, homocysteine acquires a methyl group from N-5-methyltetrahydrofolate in a vitamin B(12) dependent reaction, whereas in the transsulfuration pathway, homocysteine condenses with serine to form cystathionine in an irreversible reaction catalyzed by the pyridoxal-5"-phosphate-containing enzyme, cystathionine-beta-synthase.	Homocysteine	16-28	cystathionine beta-synthase	Homo sapiens	309-336
10758367-5	2000	In methylation, homocysteine acquires a methyl group from N-5-methyltetrahydrofolate in a vitamin B(12) dependent reaction, whereas in the transsulfuration pathway, homocysteine condenses with serine to form cystathionine in an irreversible reaction catalyzed by the pyridoxal-5"-phosphate-containing enzyme, cystathionine-beta-synthase.	Homocysteine	165-177	cystathionine beta-synthase	Homo sapiens	309-336
10704624-0	2000	Polygenic influence on plasma homocysteine: association of two prevalent mutations, the 844ins68 of cystathionine beta-synthase and A(2756)G of methionine synthase, with lowered plasma homocysteine levels.	Homocysteine	30-42	cystathionine beta-synthase	Homo sapiens	100-127
10704624-0	2000	Polygenic influence on plasma homocysteine: association of two prevalent mutations, the 844ins68 of cystathionine beta-synthase and A(2756)G of methionine synthase, with lowered plasma homocysteine levels.	Homocysteine	185-197	cystathionine beta-synthase	Homo sapiens	100-127
12725044-3	2000	The frequency of two relatively common mutations in the enzyme of cystathionine beta-synthase (CBS), which is one of the main enzymes that controls Hcy level, was examined.	Homocysteine	148-151	cystathionine beta-synthase	Homo sapiens	66-93
12725044-3	2000	The frequency of two relatively common mutations in the enzyme of cystathionine beta-synthase (CBS), which is one of the main enzymes that controls Hcy level, was examined.	Homocysteine	148-151	cystathionine beta-synthase	Homo sapiens	95-98
10564686-1	1999	BACKGROUND: Mental retardation and other disabilities (including ectopia lentis, osteoporosis, and thromboembolism) in patients who have homocystinuria as a result of a deficiency of cystathionine beta-synthase can be prevented by the screening of newborns with measurement of blood methionine, followed by the early treatment of affected infants.	Methionine	283-293	cystathionine beta-synthase	Homo sapiens	183-210
10531322-0	1999	Deletion of the regulatory domain in the pyridoxal phosphate-dependent heme protein cystathionine beta-synthase alleviates the defect observed in a catalytic site mutant.	Pyridoxal Phosphate	41-60	cystathionine beta-synthase	Homo sapiens	84-111
10687314-1	1999	Two mutations in the cystathionine beta-synthase (CBS) gene were found in two Japanese siblings with pyridoxine non-responsive homocystinuria who had different methionine levels in their blood during the neonatal period.	Pyridoxine	101-111	cystathionine beta-synthase	Homo sapiens	21-48
10687314-1	1999	Two mutations in the cystathionine beta-synthase (CBS) gene were found in two Japanese siblings with pyridoxine non-responsive homocystinuria who had different methionine levels in their blood during the neonatal period.	Pyridoxine	101-111	cystathionine beta-synthase	Homo sapiens	50-53
10687314-1	1999	Two mutations in the cystathionine beta-synthase (CBS) gene were found in two Japanese siblings with pyridoxine non-responsive homocystinuria who had different methionine levels in their blood during the neonatal period.	Methionine	160-170	cystathionine beta-synthase	Homo sapiens	21-48
10687314-1	1999	Two mutations in the cystathionine beta-synthase (CBS) gene were found in two Japanese siblings with pyridoxine non-responsive homocystinuria who had different methionine levels in their blood during the neonatal period.	Methionine	160-170	cystathionine beta-synthase	Homo sapiens	50-53
10687314-4	1999	Despite their identical genotypes and almost equal protein intake, these siblings showed different levels of blood methionine during the neonatal period, suggesting that the level of methionine in blood is determined not only by the defect in the CBS gene and protein intake, but also by the activity of other enzymes involved in methionine and homocysteine metabolism, especially during the neonatal period.	Methionine	183-193	cystathionine beta-synthase	Homo sapiens	247-250
10687314-4	1999	Despite their identical genotypes and almost equal protein intake, these siblings showed different levels of blood methionine during the neonatal period, suggesting that the level of methionine in blood is determined not only by the defect in the CBS gene and protein intake, but also by the activity of other enzymes involved in methionine and homocysteine metabolism, especially during the neonatal period.	Methionine	183-193	cystathionine beta-synthase	Homo sapiens	247-250
10444346-0	1999	Relation between plasma homocysteine concentration, the 844ins68 variant of the cystathionine beta-synthase gene, and pyridoxal-5"-phosphate concentration.	Pyridoxal Phosphate	118-140	cystathionine beta-synthase	Homo sapiens	80-107
10444346-2	1999	Cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration pathway, is important for the metabolism of homocysteine.	Homocysteine	116-128	cystathionine beta-synthase	Homo sapiens	0-27
10444346-2	1999	Cystathionine beta-synthase (CBS), a key enzyme in the transsulfuration pathway, is important for the metabolism of homocysteine.	Homocysteine	116-128	cystathionine beta-synthase	Homo sapiens	29-32
10444346-4	1999	In the current investigation, we studied 741 individuals with respect to the effect of the 68-bp insertion of the CBS gene on fasting and PML tHcy, and also determined the level of pyridoxal-5"-phosphate (vitamin B(6)), a cofactor of the CBS enzyme.	thcy	142-146	cystathionine beta-synthase	Homo sapiens	114-117
10444346-7	1999	We speculate that the 68-bp insertion is associated with somewhat higher levels of CBS enzyme activity, and that the effect of this becomes more pronounced in the presence of relatively low concentrations of pyridoxal-5"-phosphate, a cofactor of the CBS enzyme.	Pyridoxal Phosphate	208-230	cystathionine beta-synthase	Homo sapiens	83-86
10444346-7	1999	We speculate that the 68-bp insertion is associated with somewhat higher levels of CBS enzyme activity, and that the effect of this becomes more pronounced in the presence of relatively low concentrations of pyridoxal-5"-phosphate, a cofactor of the CBS enzyme.	Pyridoxal Phosphate	208-230	cystathionine beta-synthase	Homo sapiens	250-253
10052942-1	1999	Cystathionine beta-synthase (CBS), a pyridoxal 5"-phosphate (PLP) dependent enzyme, catalyzes the condensation of serine and homocysteine to form cystathionine.	Serine	114-120	cystathionine beta-synthase	Homo sapiens	0-27
10353853-0	1999	Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites	Heme	24-28	cystathionine beta-synthase	Homo sapiens	72-99
10353853-0	1999	Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites	Pyridoxal Phosphate	33-52	cystathionine beta-synthase	Homo sapiens	72-99
10336241-1	1999	Cystathionine beta-synthase (CBS) is an important enzyme for methionine metabolism.	Methionine	61-71	cystathionine beta-synthase	Homo sapiens	0-27
10336241-1	1999	Cystathionine beta-synthase (CBS) is an important enzyme for methionine metabolism.	Methionine	61-71	cystathionine beta-synthase	Homo sapiens	29-32
10052942-6	1999	Serine and hydroxylamine form an alpha-aminoacrylate and an oxime with PLP in CBS, respectively.	Hydroxylamine	11-24	cystathionine beta-synthase	Homo sapiens	78-81
10052942-1	1999	Cystathionine beta-synthase (CBS), a pyridoxal 5"-phosphate (PLP) dependent enzyme, catalyzes the condensation of serine and homocysteine to form cystathionine.	Serine	114-120	cystathionine beta-synthase	Homo sapiens	29-32
10052942-6	1999	Serine and hydroxylamine form an alpha-aminoacrylate and an oxime with PLP in CBS, respectively.	dehydroalanine	33-52	cystathionine beta-synthase	Homo sapiens	78-81
10052942-1	1999	Cystathionine beta-synthase (CBS), a pyridoxal 5"-phosphate (PLP) dependent enzyme, catalyzes the condensation of serine and homocysteine to form cystathionine.	Homocysteine	125-137	cystathionine beta-synthase	Homo sapiens	0-27
10052942-6	1999	Serine and hydroxylamine form an alpha-aminoacrylate and an oxime with PLP in CBS, respectively.	Oximes	60-65	cystathionine beta-synthase	Homo sapiens	78-81
10052942-1	1999	Cystathionine beta-synthase (CBS), a pyridoxal 5"-phosphate (PLP) dependent enzyme, catalyzes the condensation of serine and homocysteine to form cystathionine.	Homocysteine	125-137	cystathionine beta-synthase	Homo sapiens	29-32
10052942-1	1999	Cystathionine beta-synthase (CBS), a pyridoxal 5"-phosphate (PLP) dependent enzyme, catalyzes the condensation of serine and homocysteine to form cystathionine.	Cystathionine	146-159	cystathionine beta-synthase	Homo sapiens	0-27
10052944-0	1999	Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites.	Heme	24-28	cystathionine beta-synthase	Homo sapiens	72-99
10052944-0	1999	Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites.	Pyridoxal Phosphate	33-52	cystathionine beta-synthase	Homo sapiens	72-99
10052942-1	1999	Cystathionine beta-synthase (CBS), a pyridoxal 5"-phosphate (PLP) dependent enzyme, catalyzes the condensation of serine and homocysteine to form cystathionine.	Cystathionine	146-159	cystathionine beta-synthase	Homo sapiens	29-32
10052944-1	1999	Cystathionine beta-synthase is an unusual enzyme that requires the cofactors heme and pyridoxal phosphate (PLP) to catalyze the condensation of homocysteine and serine to generate cystathionine.	Heme	77-81	cystathionine beta-synthase	Homo sapiens	0-27
10052942-4	1999	In this study, treatment of CBS with sodium borohydride selectively reduced the Schiff base but did not affect the heme.	sodium borohydride	37-55	cystathionine beta-synthase	Homo sapiens	28-31
10052944-1	1999	Cystathionine beta-synthase is an unusual enzyme that requires the cofactors heme and pyridoxal phosphate (PLP) to catalyze the condensation of homocysteine and serine to generate cystathionine.	Pyridoxal Phosphate	86-105	cystathionine beta-synthase	Homo sapiens	0-27
10052944-1	1999	Cystathionine beta-synthase is an unusual enzyme that requires the cofactors heme and pyridoxal phosphate (PLP) to catalyze the condensation of homocysteine and serine to generate cystathionine.	Homocysteine	144-156	cystathionine beta-synthase	Homo sapiens	0-27
10052944-1	1999	Cystathionine beta-synthase is an unusual enzyme that requires the cofactors heme and pyridoxal phosphate (PLP) to catalyze the condensation of homocysteine and serine to generate cystathionine.	Serine	161-167	cystathionine beta-synthase	Homo sapiens	0-27
10052944-1	1999	Cystathionine beta-synthase is an unusual enzyme that requires the cofactors heme and pyridoxal phosphate (PLP) to catalyze the condensation of homocysteine and serine to generate cystathionine.	Cystathionine	180-193	cystathionine beta-synthase	Homo sapiens	0-27
10052942-4	1999	In this study, treatment of CBS with sodium borohydride selectively reduced the Schiff base but did not affect the heme.	Schiff Bases	80-91	cystathionine beta-synthase	Homo sapiens	28-31
10052942-6	1999	Serine and hydroxylamine form an alpha-aminoacrylate and an oxime with PLP in CBS, respectively.	Serine	0-6	cystathionine beta-synthase	Homo sapiens	78-81
10797837-6	1999	Nutritional status such as vitamin B12, or vitamin B6, or folate deficiencies and genetic defects such as cystathionine beta-synthase or methylene-tetrahydrofolate reductase may contribute to increasing plasma homocysteine levels.	Homocysteine	210-222	cystathionine beta-synthase	Homo sapiens	106-133
10052944-5	1999	Binding of carbon monooxide results in the displacement of a thiolate ligand to the ferrous heme, and is accompanied by complete loss of cystathionine beta-synthase activity.	Carbon Monoxide	11-27	cystathionine beta-synthase	Homo sapiens	137-164
10052944-7	1999	Binding of both CO and cyanide to ferrous cystathionine beta-synthase occurs in two distinct isotherms and indicates that the hemes are nonequivalent.	Carbon Monoxide	16-18	cystathionine beta-synthase	Homo sapiens	42-69
10052944-7	1999	Binding of both CO and cyanide to ferrous cystathionine beta-synthase occurs in two distinct isotherms and indicates that the hemes are nonequivalent.	Cyanides	23-30	cystathionine beta-synthase	Homo sapiens	42-69
10052944-7	1999	Binding of both CO and cyanide to ferrous cystathionine beta-synthase occurs in two distinct isotherms and indicates that the hemes are nonequivalent.	Heme	126-131	cystathionine beta-synthase	Homo sapiens	42-69
10052944-13	1999	Treatment of cystathionine beta-synthase with hydroxylamine releases two PLPs after 1 day and results in complete loss of activity.	Hydroxylamine	46-59	cystathionine beta-synthase	Homo sapiens	13-40
10052944-15	1999	These data lead us to revise the PLP stoichiometry to 4 per tetramer, and to the conclusion that the heme and PLP sites in cystathionine beta-synthase are nonequivalent.	Heme	101-105	cystathionine beta-synthase	Homo sapiens	123-150
10797837-4	1999	It is normally catalyzed to cystathionine by cystathionine beta-synthase a pyridoxal phosphate-dependent enzyme.	Cystathionine	28-41	cystathionine beta-synthase	Homo sapiens	45-72
10797837-4	1999	It is normally catalyzed to cystathionine by cystathionine beta-synthase a pyridoxal phosphate-dependent enzyme.	Phosphates	85-94	cystathionine beta-synthase	Homo sapiens	45-72
10338090-6	1999	Mutations due to deaminations of methylcytosines represent 53% of all point substitutions in the coding region of the CBS gene.	methylcytosines	33-48	cystathionine beta-synthase	Homo sapiens	118-121
10448523-2	1999	The two pathways are coordinated by S-adenosylmethionine, which acts as an allosteric inhibitor of the methylenetetrahydrofolate reductase reaction and as an activator of cystathionine beta-synthase.	S-Adenosylmethionine	36-56	cystathionine beta-synthase	Homo sapiens	171-198
10448523-4	1999	Severe hyperhomocysteinemia is due to rare genetic defects resulting in deficiencies in cystathionine beta synthase, methylenetetrahydrofolate reductase, or in enzymes involved in methyl-B12 synthesis and homocysteine methylation.	Homocysteine	12-24	cystathionine beta-synthase	Homo sapiens	88-115
10609891-2	1999	Selenocysteine is synthesized from selenohomocysteine by catalysis of cystathionine beta-synthase and cystathionine gamma-lyase, which both require pyridoxal phosphate.	Selenocysteine	0-14	cystathionine beta-synthase	Homo sapiens	70-97
10609891-2	1999	Selenocysteine is synthesized from selenohomocysteine by catalysis of cystathionine beta-synthase and cystathionine gamma-lyase, which both require pyridoxal phosphate.	selenomethylselenocysteine	35-53	cystathionine beta-synthase	Homo sapiens	70-97
10609891-2	1999	Selenocysteine is synthesized from selenohomocysteine by catalysis of cystathionine beta-synthase and cystathionine gamma-lyase, which both require pyridoxal phosphate.	Pyridoxal Phosphate	148-167	cystathionine beta-synthase	Homo sapiens	70-97
10363126-0	1998	Linkage disequilibrium at the cystathionine beta synthase (CBS) locus and the association between genetic variation at the CBS locus and plasma levels of homocysteine.	Homocysteine	154-166	cystathionine beta-synthase	Homo sapiens	59-62
10724918-3	1999	Two genes, CBS and MTHFR were examined, as various genotypes of these genes are thought to have impact on amino thiols, who participate in variety of reactions in vasculature.	amino thiols	106-118	cystathionine beta-synthase	Homo sapiens	11-14
9928444-2	1998	Pyridoxine, vitamin B6, is a cofactor for cystathionine beta synthase, which mediates the transformation of homocysteine to cystathionine, the initial step in the transsulfuration pathway and the urinary excretion of sulfur.	Pyridoxine	0-10	cystathionine beta-synthase	Homo sapiens	42-69
9928444-2	1998	Pyridoxine, vitamin B6, is a cofactor for cystathionine beta synthase, which mediates the transformation of homocysteine to cystathionine, the initial step in the transsulfuration pathway and the urinary excretion of sulfur.	Vitamin B 6	12-22	cystathionine beta-synthase	Homo sapiens	42-69
9928444-2	1998	Pyridoxine, vitamin B6, is a cofactor for cystathionine beta synthase, which mediates the transformation of homocysteine to cystathionine, the initial step in the transsulfuration pathway and the urinary excretion of sulfur.	Homocysteine	108-120	cystathionine beta-synthase	Homo sapiens	42-69
9928444-2	1998	Pyridoxine, vitamin B6, is a cofactor for cystathionine beta synthase, which mediates the transformation of homocysteine to cystathionine, the initial step in the transsulfuration pathway and the urinary excretion of sulfur.	Sulfur	168-174	cystathionine beta-synthase	Homo sapiens	42-69
10363126-0	1998	Linkage disequilibrium at the cystathionine beta synthase (CBS) locus and the association between genetic variation at the CBS locus and plasma levels of homocysteine.	Homocysteine	154-166	cystathionine beta-synthase	Homo sapiens	123-126
10363126-4	1998	We have examined four apparently non-functional polymorphisms in the CBS gene and have determined their frequency, degree of linkage disequilibrium and association with plasma homocysteine levels.	Homocysteine	176-188	cystathionine beta-synthase	Homo sapiens	69-72
9761242-2	1998	In the present study, we evaluated CMC in combination with capillary electrophoresis (CE) by determining the common T833C and G919A mutations in exon 8 of the cystathionine beta-synthase gene in heterozygous and homozygous samples.	cmc	35-38	cystathionine beta-synthase	Homo sapiens	159-186
9737978-0	1998	Evidence for heme-mediated redox regulation of human cystathionine beta-synthase activity.	Heme	13-17	cystathionine beta-synthase	Homo sapiens	53-80
9790750-1	1998	Cystathionine beta-synthase [CBS; l-serine hydro-lyase (adding homocysteine), EC 4.2.1.22] catalyzes the first committed step of transsulfuration and is the enzyme deficient in classical homocystinuria.	Homocysteine	63-75	cystathionine beta-synthase	Homo sapiens	0-27
9790750-1	1998	Cystathionine beta-synthase [CBS; l-serine hydro-lyase (adding homocysteine), EC 4.2.1.22] catalyzes the first committed step of transsulfuration and is the enzyme deficient in classical homocystinuria.	Homocysteine	63-75	cystathionine beta-synthase	Homo sapiens	29-32
9737978-1	1998	Human cystathionine beta-synthase catalyzes the first step in the catabolic removal of the toxic metabolite, homocysteine.	Homocysteine	109-121	cystathionine beta-synthase	Homo sapiens	6-33
9737978-10	1998	These studies provide the first evidence for redox-linked regulation of cystathionine beta-synthase which is heme-dependent.	Heme	109-113	cystathionine beta-synthase	Homo sapiens	72-99
9466825-1	1998	Cystathionine beta-synthase (CBS) catalyzes the irreversible, serine-dependent conversion of homocysteine to cystathionine via a transsulfuration pathway.	Serine	62-68	cystathionine beta-synthase	Homo sapiens	0-27
9587030-1	1998	Strategies for the treatment of cystathionine beta-synthase (CBS) deficiency include (1) increasing residual enzyme activity by giving pyridoxine in those patients with vitamin responsive variants, (2) reducing the load on the affected pathway with a low methionine diet and supplementing the diet with cysteine; and (3) giving betaine in order to utilise alternative pathways to remove homocyst(e)ine.	Pyridoxine	135-145	cystathionine beta-synthase	Homo sapiens	32-59
9587030-1	1998	Strategies for the treatment of cystathionine beta-synthase (CBS) deficiency include (1) increasing residual enzyme activity by giving pyridoxine in those patients with vitamin responsive variants, (2) reducing the load on the affected pathway with a low methionine diet and supplementing the diet with cysteine; and (3) giving betaine in order to utilise alternative pathways to remove homocyst(e)ine.	Methionine	255-265	cystathionine beta-synthase	Homo sapiens	32-59
9587030-1	1998	Strategies for the treatment of cystathionine beta-synthase (CBS) deficiency include (1) increasing residual enzyme activity by giving pyridoxine in those patients with vitamin responsive variants, (2) reducing the load on the affected pathway with a low methionine diet and supplementing the diet with cysteine; and (3) giving betaine in order to utilise alternative pathways to remove homocyst(e)ine.	Cysteine	303-311	cystathionine beta-synthase	Homo sapiens	32-59
9587030-1	1998	Strategies for the treatment of cystathionine beta-synthase (CBS) deficiency include (1) increasing residual enzyme activity by giving pyridoxine in those patients with vitamin responsive variants, (2) reducing the load on the affected pathway with a low methionine diet and supplementing the diet with cysteine; and (3) giving betaine in order to utilise alternative pathways to remove homocyst(e)ine.	Betaine	328-335	cystathionine beta-synthase	Homo sapiens	32-59
9466992-2	1998	We detected an interaction with cystathionine beta-synthase (CBS) [L-serine hydrolyase (adding homocysteine), EC 4.2.1.22], which was confirmed in vitro using His-tagged CBS expressed in Escherichia coli , which was able to specifically bind both rat and human full-length huntingtin.	Serine	69-75	cystathionine beta-synthase	Homo sapiens	61-64
9466992-2	1998	We detected an interaction with cystathionine beta-synthase (CBS) [L-serine hydrolyase (adding homocysteine), EC 4.2.1.22], which was confirmed in vitro using His-tagged CBS expressed in Escherichia coli , which was able to specifically bind both rat and human full-length huntingtin.	Serine	69-75	cystathionine beta-synthase	Homo sapiens	170-173
9466992-2	1998	We detected an interaction with cystathionine beta-synthase (CBS) [L-serine hydrolyase (adding homocysteine), EC 4.2.1.22], which was confirmed in vitro using His-tagged CBS expressed in Escherichia coli , which was able to specifically bind both rat and human full-length huntingtin.	Homocysteine	95-107	cystathionine beta-synthase	Homo sapiens	61-64
9466992-2	1998	We detected an interaction with cystathionine beta-synthase (CBS) [L-serine hydrolyase (adding homocysteine), EC 4.2.1.22], which was confirmed in vitro using His-tagged CBS expressed in Escherichia coli , which was able to specifically bind both rat and human full-length huntingtin.	Homocysteine	95-107	cystathionine beta-synthase	Homo sapiens	170-173
9466992-6	1998	Homocysteine, one of the substrates of CBS, is known to accumulate in homocystinuria and is metabolized to homocysteate and homocysteine sulphinate, both known to be powerful excitotoxic amino acids.	Homocysteine	0-12	cystathionine beta-synthase	Homo sapiens	39-42
9466992-6	1998	Homocysteine, one of the substrates of CBS, is known to accumulate in homocystinuria and is metabolized to homocysteate and homocysteine sulphinate, both known to be powerful excitotoxic amino acids.	homocysteate	107-119	cystathionine beta-synthase	Homo sapiens	39-42
9466992-6	1998	Homocysteine, one of the substrates of CBS, is known to accumulate in homocystinuria and is metabolized to homocysteate and homocysteine sulphinate, both known to be powerful excitotoxic amino acids.	homocysteine sulphinate	124-147	cystathionine beta-synthase	Homo sapiens	39-42
9675031-1	1998	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine and serine to cystathionine-an irreversible step in the eukaryotic transsulfuration pathway.	Homocysteine	64-76	cystathionine beta-synthase	Homo sapiens	0-27
9675031-1	1998	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine and serine to cystathionine-an irreversible step in the eukaryotic transsulfuration pathway.	Serine	81-87	cystathionine beta-synthase	Homo sapiens	0-27
9675031-1	1998	Cystathionine beta-synthase (CBS) catalyzes the condensation of homocysteine and serine to cystathionine-an irreversible step in the eukaryotic transsulfuration pathway.	Cystathionine	91-104	cystathionine beta-synthase	Homo sapiens	0-27
9466825-1	1998	Cystathionine beta-synthase (CBS) catalyzes the irreversible, serine-dependent conversion of homocysteine to cystathionine via a transsulfuration pathway.	Serine	62-68	cystathionine beta-synthase	Homo sapiens	29-32
9466825-1	1998	Cystathionine beta-synthase (CBS) catalyzes the irreversible, serine-dependent conversion of homocysteine to cystathionine via a transsulfuration pathway.	Homocysteine	93-105	cystathionine beta-synthase	Homo sapiens	0-27
9466825-1	1998	Cystathionine beta-synthase (CBS) catalyzes the irreversible, serine-dependent conversion of homocysteine to cystathionine via a transsulfuration pathway.	Homocysteine	93-105	cystathionine beta-synthase	Homo sapiens	29-32
9466825-1	1998	Cystathionine beta-synthase (CBS) catalyzes the irreversible, serine-dependent conversion of homocysteine to cystathionine via a transsulfuration pathway.	Cystathionine	109-122	cystathionine beta-synthase	Homo sapiens	0-27
9466825-1	1998	Cystathionine beta-synthase (CBS) catalyzes the irreversible, serine-dependent conversion of homocysteine to cystathionine via a transsulfuration pathway.	Cystathionine	109-122	cystathionine beta-synthase	Homo sapiens	29-32
9472972-0	1998	Cystathionine-beta-synthase deficiency: detection of heterozygotes by the ratios of homocysteine to cysteine and folate.	Cysteine	88-96	cystathionine beta-synthase	Homo sapiens	0-27
9472972-0	1998	Cystathionine-beta-synthase deficiency: detection of heterozygotes by the ratios of homocysteine to cysteine and folate.	Folic Acid	113-119	cystathionine beta-synthase	Homo sapiens	0-27
9701830-1	1998	Homocysteine is a metabolite of methionine that may be remethylated by enzymes requiring folate and cobalamin (vitamin B12) to again form methionine or catabolized by the pyridoxine (vitamin B6) dependent enzyme, cystathionine beta synthase (CBS) to form cysteine (fig.	Homocysteine	0-12	cystathionine beta-synthase	Homo sapiens	213-240
10215408-4	1998	RT-PCR and direct sequence analyses were used to define mutations in the cystathionine beta-synthase (CBS) gene in two unrelated male patients with vitamin B6 nonresponsive homocystinuria.	Vitamin B 6	148-158	cystathionine beta-synthase	Homo sapiens	73-100
10215408-4	1998	RT-PCR and direct sequence analyses were used to define mutations in the cystathionine beta-synthase (CBS) gene in two unrelated male patients with vitamin B6 nonresponsive homocystinuria.	Vitamin B 6	148-158	cystathionine beta-synthase	Homo sapiens	102-105
9701830-1	1998	Homocysteine is a metabolite of methionine that may be remethylated by enzymes requiring folate and cobalamin (vitamin B12) to again form methionine or catabolized by the pyridoxine (vitamin B6) dependent enzyme, cystathionine beta synthase (CBS) to form cysteine (fig.	Homocysteine	0-12	cystathionine beta-synthase	Homo sapiens	242-245
9701830-1	1998	Homocysteine is a metabolite of methionine that may be remethylated by enzymes requiring folate and cobalamin (vitamin B12) to again form methionine or catabolized by the pyridoxine (vitamin B6) dependent enzyme, cystathionine beta synthase (CBS) to form cysteine (fig.	Methionine	32-42	cystathionine beta-synthase	Homo sapiens	213-240
9701830-1	1998	Homocysteine is a metabolite of methionine that may be remethylated by enzymes requiring folate and cobalamin (vitamin B12) to again form methionine or catabolized by the pyridoxine (vitamin B6) dependent enzyme, cystathionine beta synthase (CBS) to form cysteine (fig.	Methionine	32-42	cystathionine beta-synthase	Homo sapiens	242-245
9701830-1	1998	Homocysteine is a metabolite of methionine that may be remethylated by enzymes requiring folate and cobalamin (vitamin B12) to again form methionine or catabolized by the pyridoxine (vitamin B6) dependent enzyme, cystathionine beta synthase (CBS) to form cysteine (fig.	Folic Acid	89-95	cystathionine beta-synthase	Homo sapiens	213-240
9701830-1	1998	Homocysteine is a metabolite of methionine that may be remethylated by enzymes requiring folate and cobalamin (vitamin B12) to again form methionine or catabolized by the pyridoxine (vitamin B6) dependent enzyme, cystathionine beta synthase (CBS) to form cysteine (fig.	Folic Acid	89-95	cystathionine beta-synthase	Homo sapiens	242-245
9701830-1	1998	Homocysteine is a metabolite of methionine that may be remethylated by enzymes requiring folate and cobalamin (vitamin B12) to again form methionine or catabolized by the pyridoxine (vitamin B6) dependent enzyme, cystathionine beta synthase (CBS) to form cysteine (fig.	Vitamin B 12	100-109	cystathionine beta-synthase	Homo sapiens	213-240
9701830-1	1998	Homocysteine is a metabolite of methionine that may be remethylated by enzymes requiring folate and cobalamin (vitamin B12) to again form methionine or catabolized by the pyridoxine (vitamin B6) dependent enzyme, cystathionine beta synthase (CBS) to form cysteine (fig.	Vitamin B 12	100-109	cystathionine beta-synthase	Homo sapiens	242-245
9701830-1	1998	Homocysteine is a metabolite of methionine that may be remethylated by enzymes requiring folate and cobalamin (vitamin B12) to again form methionine or catabolized by the pyridoxine (vitamin B6) dependent enzyme, cystathionine beta synthase (CBS) to form cysteine (fig.	Vitamin B 12	111-122	cystathionine beta-synthase	Homo sapiens	213-240
9701830-1	1998	Homocysteine is a metabolite of methionine that may be remethylated by enzymes requiring folate and cobalamin (vitamin B12) to again form methionine or catabolized by the pyridoxine (vitamin B6) dependent enzyme, cystathionine beta synthase (CBS) to form cysteine (fig.	Vitamin B 12	111-122	cystathionine beta-synthase	Homo sapiens	242-245
9701830-1	1998	Homocysteine is a metabolite of methionine that may be remethylated by enzymes requiring folate and cobalamin (vitamin B12) to again form methionine or catabolized by the pyridoxine (vitamin B6) dependent enzyme, cystathionine beta synthase (CBS) to form cysteine (fig.	Cysteine	4-12	cystathionine beta-synthase	Homo sapiens	213-240
9701830-1	1998	Homocysteine is a metabolite of methionine that may be remethylated by enzymes requiring folate and cobalamin (vitamin B12) to again form methionine or catabolized by the pyridoxine (vitamin B6) dependent enzyme, cystathionine beta synthase (CBS) to form cysteine (fig.	Cysteine	4-12	cystathionine beta-synthase	Homo sapiens	242-245
9367794-2	1997	In this study, we analyzed the frequency of a common 844ins68 insertion variant in the cystathionine beta-synthase gene (CBS) in patients with arterial occlusive disease and in controls and assessed the association between the insertion variant and plasma homocysteine concentrations.	Homocysteine	256-268	cystathionine beta-synthase	Homo sapiens	87-114
9357926-0	1997	Cerebrospinal fluid and plasma total homocysteine and related metabolites in children with cystathionine beta-synthase deficiency: the effect of treatment.	Homocysteine	37-49	cystathionine beta-synthase	Homo sapiens	91-118
9361025-0	1997	Functional modeling of vitamin responsiveness in yeast: a common pyridoxine-responsive cystathionine beta-synthase mutation in homocystinuria.	Pyridoxine	65-75	cystathionine beta-synthase	Homo sapiens	87-114
9361025-1	1997	Cystathionine beta-synthase (CBS) deficiency is an autosomal recessive disorder which results in extremely elevated levels of total plasma homocysteine (tHcy) and high risk of thromboembolic events.	Homocysteine	139-151	cystathionine beta-synthase	Homo sapiens	0-27
9361025-1	1997	Cystathionine beta-synthase (CBS) deficiency is an autosomal recessive disorder which results in extremely elevated levels of total plasma homocysteine (tHcy) and high risk of thromboembolic events.	thcy	153-157	cystathionine beta-synthase	Homo sapiens	0-27
9367794-2	1997	In this study, we analyzed the frequency of a common 844ins68 insertion variant in the cystathionine beta-synthase gene (CBS) in patients with arterial occlusive disease and in controls and assessed the association between the insertion variant and plasma homocysteine concentrations.	Homocysteine	256-268	cystathionine beta-synthase	Homo sapiens	121-124
9292304-6	1997	For example, the biochemical properties (and primary amino acid structures) of certain parasite methionine cycle enzymes and S-adenosylmethionine decarboxylases differ from those of the corresponding mammalian enzymes, and nematodes and trichomonads possess a novel, non-mammalian form of the trans-sulphuration enzyme cystathionine beta-synthase.	Methionine	96-106	cystathionine beta-synthase	Homo sapiens	319-346
8999883-3	1997	Here it is shown that human cells in which homocysteine metabolism is deregulated by a mutation in the cystathionine beta-synthase gene and/or by an antifolate drug, aminopterin (which prevents remethylation of homocysteine to methionine by methionine synthase), produce more homocysteine thiolactone, in addition to homocysteine, than unaffected cells.	Homocysteine	43-55	cystathionine beta-synthase	Homo sapiens	103-130
9235230-3	1997	It is normally catalysed to cystathionine by cystathionine beta-synthase a pyridoxal phosphate-dependent enzyme.	Cystathionine	28-41	cystathionine beta-synthase	Homo sapiens	45-72
9235230-3	1997	It is normally catalysed to cystathionine by cystathionine beta-synthase a pyridoxal phosphate-dependent enzyme.	Phosphates	85-94	cystathionine beta-synthase	Homo sapiens	45-72
9395725-1	1997	We present two siblings with vitamin B6-nonresponsive homocystinuria due to a deficiency of cystathionine beta-synthase who had different levels of methionine in the blood during the neonatal period, even though they had the same genetic defect.	Vitamin B 6	29-39	cystathionine beta-synthase	Homo sapiens	92-119
9395725-1	1997	We present two siblings with vitamin B6-nonresponsive homocystinuria due to a deficiency of cystathionine beta-synthase who had different levels of methionine in the blood during the neonatal period, even though they had the same genetic defect.	Methionine	148-158	cystathionine beta-synthase	Homo sapiens	92-119
9268179-10	1997	In CS-deficient patients the very high blood levels of homocysteine, probably due to deficient CS function in liver and kidney, seems to be the hazardous factor to endothelial cells, thus promoting atherosclerosis and thrombosis in CS-deficient patients.	Homocysteine	55-67	cystathionine beta-synthase	Homo sapiens	3-5
8999883-3	1997	Here it is shown that human cells in which homocysteine metabolism is deregulated by a mutation in the cystathionine beta-synthase gene and/or by an antifolate drug, aminopterin (which prevents remethylation of homocysteine to methionine by methionine synthase), produce more homocysteine thiolactone, in addition to homocysteine, than unaffected cells.	Homocysteine	211-223	cystathionine beta-synthase	Homo sapiens	103-130
8999883-3	1997	Here it is shown that human cells in which homocysteine metabolism is deregulated by a mutation in the cystathionine beta-synthase gene and/or by an antifolate drug, aminopterin (which prevents remethylation of homocysteine to methionine by methionine synthase), produce more homocysteine thiolactone, in addition to homocysteine, than unaffected cells.	Methionine	227-237	cystathionine beta-synthase	Homo sapiens	103-130
8999883-3	1997	Here it is shown that human cells in which homocysteine metabolism is deregulated by a mutation in the cystathionine beta-synthase gene and/or by an antifolate drug, aminopterin (which prevents remethylation of homocysteine to methionine by methionine synthase), produce more homocysteine thiolactone, in addition to homocysteine, than unaffected cells.	homocysteine thiolactone	276-300	cystathionine beta-synthase	Homo sapiens	103-130
8999883-3	1997	Here it is shown that human cells in which homocysteine metabolism is deregulated by a mutation in the cystathionine beta-synthase gene and/or by an antifolate drug, aminopterin (which prevents remethylation of homocysteine to methionine by methionine synthase), produce more homocysteine thiolactone, in addition to homocysteine, than unaffected cells.	Homocysteine	211-223	cystathionine beta-synthase	Homo sapiens	103-130
9156316-3	1997	We report the identification of 5 missense mutations in the protein-coding region of the CBS gene from 3 patients with pyridoxine-nonresponsive homocystinuria.	Pyridoxine	119-129	cystathionine beta-synthase	Homo sapiens	89-92
8639617-1	1996	The insertion mode of the long fatty acid chain of the asymmetric glycosphingolipid C26:0-cerebroside sulfate (C26-CBS) in symmetric matrices of phosphatidylcholines of different acyl chain length has been investigated by transmission and attenuated total reflectance (ATR) infrared spectroscopy.	long fatty acid	26-41	cystathionine beta-synthase	Homo sapiens	115-118
8990018-0	1997	Two novel mutations (K384E and L539S) in the C-terminal moiety of the cystathionine beta-synthase protein in two French pyridoxine-responsive homocystinuria patients.	Pyridoxine	120-130	cystathionine beta-synthase	Homo sapiens	70-97
8755636-0	1996	Defective cystathionine beta-synthase regulation by S-adenosylmethionine in a partially pyridoxine responsive homocystinuria patient.	S-Adenosylmethionine	52-72	cystathionine beta-synthase	Homo sapiens	10-37
8755636-0	1996	Defective cystathionine beta-synthase regulation by S-adenosylmethionine in a partially pyridoxine responsive homocystinuria patient.	Pyridoxine	88-98	cystathionine beta-synthase	Homo sapiens	10-37
8755636-1	1996	We determined the molecular basis of cystathionine beta-synthase (CBS) deficiency in a partially pyridoxine-responsive homocystinuria patient.	Pyridoxine	97-107	cystathionine beta-synthase	Homo sapiens	37-64
8755636-6	1996	The mutation was introduced in an E. coli expression system and CBS activities were measured after addition of different S-adenosylmethionine concentrations (0-200 microM).	S-Adenosylmethionine	121-141	cystathionine beta-synthase	Homo sapiens	64-67
8755636-7	1996	Again, we observed a defective stimulation of CBS activity by S-adenosylmethionine in the mutated construct, whereas the normal construct showed a threefold stimulation in activity.	S-Adenosylmethionine	62-82	cystathionine beta-synthase	Homo sapiens	46-49
8755636-8	1996	These data suggest that this D444N mutation interferes in S-adenosylmethionine regulation of CBS.	Sulfur	58-60	cystathionine beta-synthase	Homo sapiens	93-96
8755636-8	1996	These data suggest that this D444N mutation interferes in S-adenosylmethionine regulation of CBS.	S-Adenosylmethionine	60-78	cystathionine beta-synthase	Homo sapiens	93-96
8986631-7	1996	This may account for the looser relationship between Hcy and its transsulfuration product, Cys, in females (R2 = 0.30) compared to males (R2 = 0.73), since conversion of methionine to SAM in males would activate cystathionine beta synthase and commit excess Hcy to transsulfuration.	Homocysteine	53-56	cystathionine beta-synthase	Homo sapiens	212-239
8986631-7	1996	This may account for the looser relationship between Hcy and its transsulfuration product, Cys, in females (R2 = 0.30) compared to males (R2 = 0.73), since conversion of methionine to SAM in males would activate cystathionine beta synthase and commit excess Hcy to transsulfuration.	Methionine	170-180	cystathionine beta-synthase	Homo sapiens	212-239
8986631-7	1996	This may account for the looser relationship between Hcy and its transsulfuration product, Cys, in females (R2 = 0.30) compared to males (R2 = 0.73), since conversion of methionine to SAM in males would activate cystathionine beta synthase and commit excess Hcy to transsulfuration.	Homocysteine	258-261	cystathionine beta-synthase	Homo sapiens	212-239
8639617-1	1996	The insertion mode of the long fatty acid chain of the asymmetric glycosphingolipid C26:0-cerebroside sulfate (C26-CBS) in symmetric matrices of phosphatidylcholines of different acyl chain length has been investigated by transmission and attenuated total reflectance (ATR) infrared spectroscopy.	Glycosphingolipids	66-83	cystathionine beta-synthase	Homo sapiens	115-118
8639617-1	1996	The insertion mode of the long fatty acid chain of the asymmetric glycosphingolipid C26:0-cerebroside sulfate (C26-CBS) in symmetric matrices of phosphatidylcholines of different acyl chain length has been investigated by transmission and attenuated total reflectance (ATR) infrared spectroscopy.	c26:0-cerebroside sulfate	84-109	cystathionine beta-synthase	Homo sapiens	115-118
8639617-1	1996	The insertion mode of the long fatty acid chain of the asymmetric glycosphingolipid C26:0-cerebroside sulfate (C26-CBS) in symmetric matrices of phosphatidylcholines of different acyl chain length has been investigated by transmission and attenuated total reflectance (ATR) infrared spectroscopy.	Phosphatidylcholines	145-165	cystathionine beta-synthase	Homo sapiens	115-118
8639617-3	1996	The conformational order and the orientation of the chains of the asymmetric glycosphingolipid have been evaluated for C26-CBS incorporated at 8 mol % in perdeuterated dimyristoylphosphatidylcholine (DMPC-d54) and perdeuterated dipalmitoylphosphatidylcholine (DPPC-d62).	Glycosphingolipids	77-94	cystathionine beta-synthase	Homo sapiens	123-126
8639617-4	1996	The results, for the gel phase, are consistent with interdigitation of the C26-CBS long acyl chain across the bilayer center of an all-trans-DMPC bilayer in which DMPC is less tilted than in the absence of CBS.	Dimyristoylphosphatidylcholine	141-145	cystathionine beta-synthase	Homo sapiens	79-82
8639617-4	1996	The results, for the gel phase, are consistent with interdigitation of the C26-CBS long acyl chain across the bilayer center of an all-trans-DMPC bilayer in which DMPC is less tilted than in the absence of CBS.	Dimyristoylphosphatidylcholine	163-167	cystathionine beta-synthase	Homo sapiens	79-82
8639617-5	1996	In contrast, in DPPC the results suggest that although the CBS long chain interdigitates across the center of the bilayer, it does not change the tilt angle of the DPPC molecules in the gel phase.	1,2-Dipalmitoylphosphatidylcholine	16-20	cystathionine beta-synthase	Homo sapiens	59-62
8639617-6	1996	Furthermore, in DPPC, C26-CBS is less well oriented than the host DPPC molecules and it increases the gauche content of the DPPC acyl chains.	1,2-Dipalmitoylphosphatidylcholine	16-20	cystathionine beta-synthase	Homo sapiens	26-29
8639617-6	1996	Furthermore, in DPPC, C26-CBS is less well oriented than the host DPPC molecules and it increases the gauche content of the DPPC acyl chains.	1,2-Dipalmitoylphosphatidylcholine	66-70	cystathionine beta-synthase	Homo sapiens	26-29
8639617-6	1996	Furthermore, in DPPC, C26-CBS is less well oriented than the host DPPC molecules and it increases the gauche content of the DPPC acyl chains.	1,2-Dipalmitoylphosphatidylcholine	66-70	cystathionine beta-synthase	Homo sapiens	26-29
8639617-8	1996	The thermotropic behavior of the lipid mixtures of C26-CBS at 8 mol % in DMPC or DPPC shows that the glycosphingolipid stabilizes the gel phase of the short chain length bilayer while it destabilizes the long chain length one.	Dimyristoylphosphatidylcholine	73-77	cystathionine beta-synthase	Homo sapiens	55-58
8639617-8	1996	The thermotropic behavior of the lipid mixtures of C26-CBS at 8 mol % in DMPC or DPPC shows that the glycosphingolipid stabilizes the gel phase of the short chain length bilayer while it destabilizes the long chain length one.	1,2-Dipalmitoylphosphatidylcholine	81-85	cystathionine beta-synthase	Homo sapiens	55-58
8639617-8	1996	The thermotropic behavior of the lipid mixtures of C26-CBS at 8 mol % in DMPC or DPPC shows that the glycosphingolipid stabilizes the gel phase of the short chain length bilayer while it destabilizes the long chain length one.	Glycosphingolipids	101-118	cystathionine beta-synthase	Homo sapiens	55-58
8639617-9	1996	Our results further demonstrate that, at this concentration, C26-CBS is completely miscible in DMPC and DPPC in the gel and the liquid crystalline phases.	Dimyristoylphosphatidylcholine	95-99	cystathionine beta-synthase	Homo sapiens	65-68
8639617-9	1996	Our results further demonstrate that, at this concentration, C26-CBS is completely miscible in DMPC and DPPC in the gel and the liquid crystalline phases.	1,2-Dipalmitoylphosphatidylcholine	104-108	cystathionine beta-synthase	Homo sapiens	65-68
8639617-10	1996	The difference in behavior of C26-CBS in DMPC and DPPC is a consequence of the greater mismatch between the C26 chain length and the bilayer thickness of DPPC relative to DMPC.	Dimyristoylphosphatidylcholine	41-45	cystathionine beta-synthase	Homo sapiens	34-37
8639617-10	1996	The difference in behavior of C26-CBS in DMPC and DPPC is a consequence of the greater mismatch between the C26 chain length and the bilayer thickness of DPPC relative to DMPC.	1,2-Dipalmitoylphosphatidylcholine	50-54	cystathionine beta-synthase	Homo sapiens	34-37
8639617-10	1996	The difference in behavior of C26-CBS in DMPC and DPPC is a consequence of the greater mismatch between the C26 chain length and the bilayer thickness of DPPC relative to DMPC.	1,2-Dipalmitoylphosphatidylcholine	154-158	cystathionine beta-synthase	Homo sapiens	34-37
8639617-10	1996	The difference in behavior of C26-CBS in DMPC and DPPC is a consequence of the greater mismatch between the C26 chain length and the bilayer thickness of DPPC relative to DMPC.	Dimyristoylphosphatidylcholine	171-175	cystathionine beta-synthase	Homo sapiens	34-37
8744616-8	1996	This is the first report of a normal methionine load test in a proven heterozygote for a CBS mutation which causes severe homocystinuria in the homozygote.	Methionine	37-47	cystathionine beta-synthase	Homo sapiens	89-92
8605357-8	1996	These in vitro studies support our hypothesis that enhanced metabolism of ara-C in DS cells may be a contributing factor to the superior survival rate of DS children with AML and is possibly based on a gene dosage effect of genes localized to chromosome 21 including cystathionine-beta-synthase.	Cytarabine	74-79	cystathionine beta-synthase	Homo sapiens	267-294
8724113-5	1996	There was significant correlation between homocysteine concentrations and CBS activities only after methionine loading (r = 0.12, 0.48, 0.48 and 0.50 at 0, 4, 6 and 8 h, respectively).	Homocysteine	42-54	cystathionine beta-synthase	Homo sapiens	74-77
8724113-5	1996	There was significant correlation between homocysteine concentrations and CBS activities only after methionine loading (r = 0.12, 0.48, 0.48 and 0.50 at 0, 4, 6 and 8 h, respectively).	Methionine	100-110	cystathionine beta-synthase	Homo sapiens	74-77
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	227-230	cystathionine beta-synthase	Homo sapiens	94-97
8642474-5	1996	Long-term betaine supplementation of 10 patients, who had pyridoxine-resistant homocystinuria and gross hyperhomocysteinemia due to deficiency of cystathionine beta-synthase activity, caused a substantial lowering of plasma homocysteine, which has now been maintained for periods of up to 13 years.	Betaine	10-17	cystathionine beta-synthase	Homo sapiens	146-173
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	227-230	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	43-46	cystathionine beta-synthase	Homo sapiens	65-92
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	43-46	cystathionine beta-synthase	Homo sapiens	94-97
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	227-230	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	43-46	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	227-230	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	43-46	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	43-46	cystathionine beta-synthase	Homo sapiens	144-147
7628074-3	1995	Rare genetic disorders of vitamin B12 synthesis of 5"-10"-methylene tetrahydrofolate reductase, or the pyridoxal phosphate-dependent enzyme cystathionine beta-synthase may cause severe hyperhomocyst(e)inemia and homocystinuria.	Phosphates	113-122	cystathionine beta-synthase	Homo sapiens	140-167
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydroxylamine	159-172	cystathionine beta-synthase	Homo sapiens	65-92
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydroxylamine	159-172	cystathionine beta-synthase	Homo sapiens	94-97
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydroxylamine	159-172	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydroxylamine	159-172	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydroxylamine	159-172	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Aminooxyacetic Acid	177-193	cystathionine beta-synthase	Homo sapiens	65-92
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Aminooxyacetic Acid	177-193	cystathionine beta-synthase	Homo sapiens	94-97
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Aminooxyacetic Acid	177-193	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Aminooxyacetic Acid	177-193	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Aminooxyacetic Acid	177-193	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	227-230	cystathionine beta-synthase	Homo sapiens	65-92
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	227-230	cystathionine beta-synthase	Homo sapiens	94-97
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	227-230	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	227-230	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	227-230	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	S-Adenosylmethionine	257-280	cystathionine beta-synthase	Homo sapiens	65-92
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	S-Adenosylmethionine	257-280	cystathionine beta-synthase	Homo sapiens	94-97
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	S-Adenosylmethionine	257-280	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	S-Adenosylmethionine	257-280	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	S-Adenosylmethionine	257-280	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	227-230	cystathionine beta-synthase	Homo sapiens	65-92
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	227-230	cystathionine beta-synthase	Homo sapiens	94-97
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	227-230	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	227-230	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	227-230	cystathionine beta-synthase	Homo sapiens	144-147
8558235-4	1996	In this work we show the following: (1) an H2S-producing enzyme, cystathionine beta-synthase (CBS), is highly expressed in the hippocampus; (2) CBS inhibitors hydroxylamine and amino-oxyacetate suppress the production of brain H2S; and (3) a CBS activator, S-adenosyl-L-methionine, enhances H2S production, indicating that CBS contributes to the production of endogenous H2S.	Hydrogen Sulfide	227-230	cystathionine beta-synthase	Homo sapiens	65-92
8554066-2	1996	Genetic aberrations in the cystathionine beta-synthase (CBS) and methylenetetrahydrofolate reductase (MTHFR) genes may account for reduced enzyme activities and elevated plasma homocysteine levels.	Homocysteine	177-189	cystathionine beta-synthase	Homo sapiens	27-54
8554066-2	1996	Genetic aberrations in the cystathionine beta-synthase (CBS) and methylenetetrahydrofolate reductase (MTHFR) genes may account for reduced enzyme activities and elevated plasma homocysteine levels.	Homocysteine	177-189	cystathionine beta-synthase	Homo sapiens	56-59
8803779-0	1996	Homocysteine response to methionine challenge in four obligate heterozygotes for homocystinuria and relationship with cystathionine beta-synthase mutations.	Homocysteine	0-12	cystathionine beta-synthase	Homo sapiens	118-145
7611281-1	1995	Deficiency of cystathionine beta-synthase (CBS) is a genetic disorder of transsulfuration resulting in elevated plasma homocyst(e)ine and methionine and decreased cysteine.	Methionine	138-148	cystathionine beta-synthase	Homo sapiens	14-41
7611281-1	1995	Deficiency of cystathionine beta-synthase (CBS) is a genetic disorder of transsulfuration resulting in elevated plasma homocyst(e)ine and methionine and decreased cysteine.	Cysteine	163-171	cystathionine beta-synthase	Homo sapiens	14-41
7611293-0	1995	A missense mutation (I278T) in the cystathionine beta-synthase gene prevalent in pyridoxine-responsive homocystinuria and associated with mild clinical phenotype.	Pyridoxine	81-91	cystathionine beta-synthase	Homo sapiens	35-62
7929220-6	1994	Human CBS, expressed in Escherichia coli, acquires heme b from the host bacteria.	Heme	51-57	cystathionine beta-synthase	Homo sapiens	6-9
7840623-0	1995	Delta-aminolevulinate increases heme saturation and yield of human cystathionine beta-synthase expressed in Escherichia coli.	Aminolevulinic Acid	0-21	cystathionine beta-synthase	Homo sapiens	67-94
7840623-2	1995	We showed that CBS requires heme in addition to pyridoxal 5"-phosphate for its function.	Heme	28-32	cystathionine beta-synthase	Homo sapiens	15-18
7840623-2	1995	We showed that CBS requires heme in addition to pyridoxal 5"-phosphate for its function.	Pyridoxal Phosphate	48-70	cystathionine beta-synthase	Homo sapiens	15-18
7840623-3	1995	Previously, CBS, only about 20% saturated with heme, was purified from transformed bacteria.	Heme	47-51	cystathionine beta-synthase	Homo sapiens	12-15
7840623-6	1995	The increase in heme biosynthesis depended on the overexpression of a heme acceptor--CBS.	Heme	16-20	cystathionine beta-synthase	Homo sapiens	85-88
7840623-6	1995	The increase in heme biosynthesis depended on the overexpression of a heme acceptor--CBS.	Heme	70-74	cystathionine beta-synthase	Homo sapiens	85-88
7840623-8	1995	The delta ALA treatment resulted in 8 times more total CBS activity with a 3.5-fold higher yield of the purified recombinant enzyme, more than 68% saturated with heme.	Alanine	10-13	cystathionine beta-synthase	Homo sapiens	55-58
7840623-8	1995	The delta ALA treatment resulted in 8 times more total CBS activity with a 3.5-fold higher yield of the purified recombinant enzyme, more than 68% saturated with heme.	Heme	162-166	cystathionine beta-synthase	Homo sapiens	55-58
7840623-9	1995	Increased yield, higher specific activity, and improved heme saturation of CBS will facilitate large-scale preparation of the enzyme.	Heme	56-60	cystathionine beta-synthase	Homo sapiens	75-78
7967489-4	1994	CBS, a tetramer of these subunits, binds its two substrates, homocysteine and serine, and three additional ligands: pyridoxal 5"-phosphate, S-adenosylmethionine, and haem.	Homocysteine	61-73	cystathionine beta-synthase	Homo sapiens	0-3
7827502-3	1994	Proteolytic treatment of the ammonium sulfate fraction of bacterial lysates with endoproteinase Xa liberated CBS which could then be separated from its fusion partner by DEAE-cellulose chromatography.	Ammonium Sulfate	29-45	cystathionine beta-synthase	Homo sapiens	109-112
7827502-3	1994	Proteolytic treatment of the ammonium sulfate fraction of bacterial lysates with endoproteinase Xa liberated CBS which could then be separated from its fusion partner by DEAE-cellulose chromatography.	DEAE-Cellulose	170-184	cystathionine beta-synthase	Homo sapiens	109-112
7981678-1	1994	We determined the molecular basis of cystathionine beta-synthase (CBS) deficiency in three siblings with pyridoxine responsive homocystinuria using a significantly improved mutation screening method in bacteria.	Pyridoxine	105-115	cystathionine beta-synthase	Homo sapiens	37-64
7981678-1	1994	We determined the molecular basis of cystathionine beta-synthase (CBS) deficiency in three siblings with pyridoxine responsive homocystinuria using a significantly improved mutation screening method in bacteria.	Pyridoxine	105-115	cystathionine beta-synthase	Homo sapiens	66-69
7967489-4	1994	CBS, a tetramer of these subunits, binds its two substrates, homocysteine and serine, and three additional ligands: pyridoxal 5"-phosphate, S-adenosylmethionine, and haem.	Serine	78-84	cystathionine beta-synthase	Homo sapiens	0-3
7967489-4	1994	CBS, a tetramer of these subunits, binds its two substrates, homocysteine and serine, and three additional ligands: pyridoxal 5"-phosphate, S-adenosylmethionine, and haem.	Pyridoxal Phosphate	116-138	cystathionine beta-synthase	Homo sapiens	0-3
7967489-4	1994	CBS, a tetramer of these subunits, binds its two substrates, homocysteine and serine, and three additional ligands: pyridoxal 5"-phosphate, S-adenosylmethionine, and haem.	S-Adenosylmethionine	140-160	cystathionine beta-synthase	Homo sapiens	0-3
7967489-4	1994	CBS, a tetramer of these subunits, binds its two substrates, homocysteine and serine, and three additional ligands: pyridoxal 5"-phosphate, S-adenosylmethionine, and haem.	Heme	166-170	cystathionine beta-synthase	Homo sapiens	0-3
8507876-2	1993	Homocysteine can also condense with serine to form cystathionine in a pyridoxal phosphate-dependent reaction catalyzed by cystathionine beta-synthase.	Homocysteine	0-12	cystathionine beta-synthase	Homo sapiens	122-149
8134195-1	1994	We investigated the nitrous oxide-induced inactivation of methionine synthase and the concurrent homocysteine (Hcy) export in mutant fibroblasts with defects in the homocysteine catabolizing enzyme, cystathionine beta-synthase, or in methionine synthase, which carries out homocysteine remethylation.	Nitrous Oxide	20-33	cystathionine beta-synthase	Homo sapiens	199-226
8134195-3	1994	In cystathionine beta-synthase-deficient cells, high medium methionine partly protected the enzyme against inactivation, as previously found in normal fibroblasts.	Methionine	60-70	cystathionine beta-synthase	Homo sapiens	3-30
8134195-9	1994	These data suggest that Hcy remethylation and cystathionine beta-synthase activity are major determinants of Hcy export at low and high methionine, respectively.	Methionine	136-146	cystathionine beta-synthase	Homo sapiens	46-73
8507876-2	1993	Homocysteine can also condense with serine to form cystathionine in a pyridoxal phosphate-dependent reaction catalyzed by cystathionine beta-synthase.	Serine	36-42	cystathionine beta-synthase	Homo sapiens	122-149
8507876-2	1993	Homocysteine can also condense with serine to form cystathionine in a pyridoxal phosphate-dependent reaction catalyzed by cystathionine beta-synthase.	Cystathionine	51-64	cystathionine beta-synthase	Homo sapiens	122-149
8507876-2	1993	Homocysteine can also condense with serine to form cystathionine in a pyridoxal phosphate-dependent reaction catalyzed by cystathionine beta-synthase.	Pyridoxal Phosphate	70-89	cystathionine beta-synthase	Homo sapiens	122-149
8507876-8	1993	Five homozygotes for cystathionine beta-synthase deficiency had high values for serum-total homocysteine and low or low-normal values for serum cystathionine that ranged from 30 nmol/L to 114 nmol/L even though they were on treatment with pyridoxine and had partially responded.	Homocysteine	92-104	cystathionine beta-synthase	Homo sapiens	21-48
8507876-8	1993	Five homozygotes for cystathionine beta-synthase deficiency had high values for serum-total homocysteine and low or low-normal values for serum cystathionine that ranged from 30 nmol/L to 114 nmol/L even though they were on treatment with pyridoxine and had partially responded.	Pyridoxine	239-249	cystathionine beta-synthase	Homo sapiens	21-48
1540621-2	1992	S-Aminoethylcysteine, which could be considered as the natural precursor of the ketimine, is produced from L-serine and cysteamine by the action of the enzyme cystathionine-beta-synthase.	S-2-aminoethyl cysteine	0-20	cystathionine beta-synthase	Homo sapiens	159-186
1493873-1	1992	Characterization of the physical and catalytic properties of the enzyme responsible for nematode "activated L-serine sulfhydrase" activity (L-cysteine + R-SH--&gt;cysteine thioether + H2S) has led to its identification as a novel, variant form (allelozyme) of cystathionine beta-synthase that is distinct from a mammalian-type synthase also present in nematodes.	Cysteine	140-150	cystathionine beta-synthase	Homo sapiens	260-287
1540621-2	1992	S-Aminoethylcysteine, which could be considered as the natural precursor of the ketimine, is produced from L-serine and cysteamine by the action of the enzyme cystathionine-beta-synthase.	ketimine	80-88	cystathionine beta-synthase	Homo sapiens	159-186
1540621-2	1992	S-Aminoethylcysteine, which could be considered as the natural precursor of the ketimine, is produced from L-serine and cysteamine by the action of the enzyme cystathionine-beta-synthase.	Serine	107-115	cystathionine beta-synthase	Homo sapiens	159-186
1540621-2	1992	S-Aminoethylcysteine, which could be considered as the natural precursor of the ketimine, is produced from L-serine and cysteamine by the action of the enzyme cystathionine-beta-synthase.	Cysteamine	120-130	cystathionine beta-synthase	Homo sapiens	159-186
1757192-7	1991	Particularly striking was the ability of N. brasiliensis cystathionine beta-synthase to catalyse the non-mammalian "activated L-serine sulphydrase" reaction (L-cysteine + R-SH----cysteine thioether + H2S).	Cysteine	158-168	cystathionine beta-synthase	Homo sapiens	57-84
1757192-7	1991	Particularly striking was the ability of N. brasiliensis cystathionine beta-synthase to catalyse the non-mammalian "activated L-serine sulphydrase" reaction (L-cysteine + R-SH----cysteine thioether + H2S).	r-sh----cysteine thioether	171-197	cystathionine beta-synthase	Homo sapiens	57-84
1757192-7	1991	Particularly striking was the ability of N. brasiliensis cystathionine beta-synthase to catalyse the non-mammalian "activated L-serine sulphydrase" reaction (L-cysteine + R-SH----cysteine thioether + H2S).	Hydrogen Sulfide	200-203	cystathionine beta-synthase	Homo sapiens	57-84
2011158-1	1991	BACKGROUND: Hyperhomocysteinemia arising from impaired methionine metabolism, probably usually due to a deficiency of cystathionine beta-synthase, is associated with premature cerebral, peripheral, and possibly coronary vascular disease.	Methionine	55-65	cystathionine beta-synthase	Homo sapiens	118-145
1800166-0	1991	A randomised double blind trial comparing the treatment of episcleritis with topical 2-(2-Hydroxy-4-methylphenyl) Aminothiazole Hydrochloride 0.1% (CBS 113A) and placebo.	2-(2-hydroxy-4-methylphenyl)	85-113	cystathionine beta-synthase	Homo sapiens	148-151
1800166-0	1991	A randomised double blind trial comparing the treatment of episcleritis with topical 2-(2-Hydroxy-4-methylphenyl) Aminothiazole Hydrochloride 0.1% (CBS 113A) and placebo.	2-Aminothiazole hydrochloride	114-141	cystathionine beta-synthase	Homo sapiens	148-151
1800166-1	1991	A randomised double blind trial of 2-(2-Hydroxy-4-methylphenyl) Aminothiazole Hydrochloride 0.1% (CBS 113A) versus placebo was carried out in 43 eyes with episcleritis.	2-Aminothiazole hydrochloride	64-91	cystathionine beta-synthase	Homo sapiens	98-101
18278872-0	2008	Dioxygen reactivity and heme redox potential of truncated human cystathionine beta-synthase.	Heme	24-28	cystathionine beta-synthase	Homo sapiens	64-91
1805216-4	1991	However, the most important feature of the survey was the widespread ability of nematode cystathionine beta-synthase to catalyse the non-mammalian "activated L-serine sulphhydrase" reaction (L-cysteine + R-SH----cysteine thioether + H2S).	Cysteine	191-201	cystathionine beta-synthase	Homo sapiens	89-116
1805216-4	1991	However, the most important feature of the survey was the widespread ability of nematode cystathionine beta-synthase to catalyse the non-mammalian "activated L-serine sulphhydrase" reaction (L-cysteine + R-SH----cysteine thioether + H2S).	r-sh----cysteine thioether	204-230	cystathionine beta-synthase	Homo sapiens	89-116
1805216-4	1991	However, the most important feature of the survey was the widespread ability of nematode cystathionine beta-synthase to catalyse the non-mammalian "activated L-serine sulphhydrase" reaction (L-cysteine + R-SH----cysteine thioether + H2S).	Hydrogen Sulfide	233-236	cystathionine beta-synthase	Homo sapiens	89-116
1971518-3	1990	Glutathione reductase and cystathionine-beta-synthase responded more vigorously to methionine injections, which was especially well pronounced in animals with prominent pheomelaninogenesis and in albino animals.	Methionine	83-93	cystathionine beta-synthase	Homo sapiens	26-53
33824770-1	2021	Homocystinuria is a rare autosomal recessive metabolic disorder due to a defect in the cystathionine beta-synthase (CBS) that leads to high homocysteine plasma levels.	Homocysteine	140-152	cystathionine beta-synthase	Homo sapiens	87-114
33824770-1	2021	Homocystinuria is a rare autosomal recessive metabolic disorder due to a defect in the cystathionine beta-synthase (CBS) that leads to high homocysteine plasma levels.	Homocysteine	140-152	cystathionine beta-synthase	Homo sapiens	116-119
2407253-2	1990	Severe homocysteinemia due to genetic defects either of pyridoxal 5-phosphate (PLP)-dependent cystathionine beta-synthase (CBS) or of enzymes in vitamin B12 and folate metabolism is associated with very early-onset vascular disease.	Pyridoxal Phosphate	56-77	cystathionine beta-synthase	Homo sapiens	94-121
2407253-2	1990	Severe homocysteinemia due to genetic defects either of pyridoxal 5-phosphate (PLP)-dependent cystathionine beta-synthase (CBS) or of enzymes in vitamin B12 and folate metabolism is associated with very early-onset vascular disease.	Pyridoxal Phosphate	56-77	cystathionine beta-synthase	Homo sapiens	123-126
2407253-2	1990	Severe homocysteinemia due to genetic defects either of pyridoxal 5-phosphate (PLP)-dependent cystathionine beta-synthase (CBS) or of enzymes in vitamin B12 and folate metabolism is associated with very early-onset vascular disease.	Pyridoxal Phosphate	79-82	cystathionine beta-synthase	Homo sapiens	94-121
2407253-2	1990	Severe homocysteinemia due to genetic defects either of pyridoxal 5-phosphate (PLP)-dependent cystathionine beta-synthase (CBS) or of enzymes in vitamin B12 and folate metabolism is associated with very early-onset vascular disease.	Pyridoxal Phosphate	79-82	cystathionine beta-synthase	Homo sapiens	123-126
29743070-8	2018	The mRNA and protein expression of the enzymes responsible for endogenous H2S production (cystathionine-beta-synthase [CBS] and 3-mercaptopyruvate sulphur transferase [MPST]) were inhibited by H2S donors.	Hydrogen Sulfide	74-77	cystathionine beta-synthase	Homo sapiens	90-117
29743070-8	2018	The mRNA and protein expression of the enzymes responsible for endogenous H2S production (cystathionine-beta-synthase [CBS] and 3-mercaptopyruvate sulphur transferase [MPST]) were inhibited by H2S donors.	Hydrogen Sulfide	193-196	cystathionine beta-synthase	Homo sapiens	90-117
18278872-0	2008	Dioxygen reactivity and heme redox potential of truncated human cystathionine beta-synthase.	Oxygen	0-8	cystathionine beta-synthase	Homo sapiens	64-91
18278872-1	2008	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to cystathionine, which represents the committing step in the transsulfuration pathway.	Serine	64-70	cystathionine beta-synthase	Homo sapiens	0-27
18278872-1	2008	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to cystathionine, which represents the committing step in the transsulfuration pathway.	Serine	64-70	cystathionine beta-synthase	Homo sapiens	29-32
18278872-1	2008	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to cystathionine, which represents the committing step in the transsulfuration pathway.	Homocysteine	75-87	cystathionine beta-synthase	Homo sapiens	0-27
18278872-1	2008	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to cystathionine, which represents the committing step in the transsulfuration pathway.	Homocysteine	75-87	cystathionine beta-synthase	Homo sapiens	29-32
18278872-1	2008	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to cystathionine, which represents the committing step in the transsulfuration pathway.	Cystathionine	91-104	cystathionine beta-synthase	Homo sapiens	0-27
18278872-1	2008	Cystathionine beta-synthase (CBS) catalyzes the condensation of serine and homocysteine to cystathionine, which represents the committing step in the transsulfuration pathway.	Cystathionine	91-104	cystathionine beta-synthase	Homo sapiens	29-32
18278872-2	2008	CBS is unique in being a pyridoxal phosphate-dependent enzyme that has a heme cofactor.	Pyridoxal Phosphate	25-44	cystathionine beta-synthase	Homo sapiens	0-3
18278872-2	2008	CBS is unique in being a pyridoxal phosphate-dependent enzyme that has a heme cofactor.	Heme	73-77	cystathionine beta-synthase	Homo sapiens	0-3
18278872-3	2008	The activity of CBS under in vitro conditions is responsive to the redox state of the heme, which is distant from the active site and has been postulated to play a regulatory role.	Heme	86-90	cystathionine beta-synthase	Homo sapiens	16-19
18278872-4	2008	The heme in CBS is unusual; it is six-coordinate, low spin, and contains cysteine and histidine as axial ligands.	Heme	4-8	cystathionine beta-synthase	Homo sapiens	12-15
18278872-4	2008	The heme in CBS is unusual; it is six-coordinate, low spin, and contains cysteine and histidine as axial ligands.	Cysteine	73-81	cystathionine beta-synthase	Homo sapiens	12-15
18278872-4	2008	The heme in CBS is unusual; it is six-coordinate, low spin, and contains cysteine and histidine as axial ligands.	Histidine	86-95	cystathionine beta-synthase	Homo sapiens	12-15
18278872-7	2008	Stopped-flow kinetic determinations demonstrated that Fe(II)CBS reacted with dioxygen yielding Fe(III)CBS without detectable formation of an intermediate species.	ammonium ferrous sulfate	54-60	cystathionine beta-synthase	Homo sapiens	102-105
18278872-7	2008	Stopped-flow kinetic determinations demonstrated that Fe(II)CBS reacted with dioxygen yielding Fe(III)CBS without detectable formation of an intermediate species.	Oxygen	77-85	cystathionine beta-synthase	Homo sapiens	60-63
18278872-7	2008	Stopped-flow kinetic determinations demonstrated that Fe(II)CBS reacted with dioxygen yielding Fe(III)CBS without detectable formation of an intermediate species.	Oxygen	77-85	cystathionine beta-synthase	Homo sapiens	102-105
18278872-7	2008	Stopped-flow kinetic determinations demonstrated that Fe(II)CBS reacted with dioxygen yielding Fe(III)CBS without detectable formation of an intermediate species.	ferric sulfate	95-102	cystathionine beta-synthase	Homo sapiens	60-63
18278872-8	2008	A linear dependence of the apparent rate constant of Fe(II)CBS decay on dioxygen concentration was observed and yielded a second-order rate constant of (1.11 +/- 0.07) x 10 (5) M (-1) s (-1) at pH 7.4 and 25 degrees C for the direct reaction of Fe(II)CBS with dioxygen.	ammonium ferrous sulfate	53-59	cystathionine beta-synthase	Homo sapiens	251-254
18278872-8	2008	A linear dependence of the apparent rate constant of Fe(II)CBS decay on dioxygen concentration was observed and yielded a second-order rate constant of (1.11 +/- 0.07) x 10 (5) M (-1) s (-1) at pH 7.4 and 25 degrees C for the direct reaction of Fe(II)CBS with dioxygen.	Oxygen	72-80	cystathionine beta-synthase	Homo sapiens	59-62
18278872-8	2008	A linear dependence of the apparent rate constant of Fe(II)CBS decay on dioxygen concentration was observed and yielded a second-order rate constant of (1.11 +/- 0.07) x 10 (5) M (-1) s (-1) at pH 7.4 and 25 degrees C for the direct reaction of Fe(II)CBS with dioxygen.	Oxygen	72-80	cystathionine beta-synthase	Homo sapiens	251-254
18278872-8	2008	A linear dependence of the apparent rate constant of Fe(II)CBS decay on dioxygen concentration was observed and yielded a second-order rate constant of (1.11 +/- 0.07) x 10 (5) M (-1) s (-1) at pH 7.4 and 25 degrees C for the direct reaction of Fe(II)CBS with dioxygen.	ammonium ferrous sulfate	245-251	cystathionine beta-synthase	Homo sapiens	59-62
18278872-8	2008	A linear dependence of the apparent rate constant of Fe(II)CBS decay on dioxygen concentration was observed and yielded a second-order rate constant of (1.11 +/- 0.07) x 10 (5) M (-1) s (-1) at pH 7.4 and 25 degrees C for the direct reaction of Fe(II)CBS with dioxygen.	Oxygen	260-268	cystathionine beta-synthase	Homo sapiens	59-62
18278872-8	2008	A linear dependence of the apparent rate constant of Fe(II)CBS decay on dioxygen concentration was observed and yielded a second-order rate constant of (1.11 +/- 0.07) x 10 (5) M (-1) s (-1) at pH 7.4 and 25 degrees C for the direct reaction of Fe(II)CBS with dioxygen.	Oxygen	260-268	cystathionine beta-synthase	Homo sapiens	251-254
18278872-11	2008	Our results show that CBS may represent a previously unrecognized source of cytosolic superoxide radical.	Superoxides	86-104	cystathionine beta-synthase	Homo sapiens	22-25
34657441-1	2021	Pregnancy and VEGF (vascular endothelial growth factor) stimulate uterine artery endothelial cell (UAEC) hydrogen sulfide production via selectively upregulating CBS (cystathionine beta-synthase) but not CSE (cystathionine gamma-lyase) expression.	Hydrogen Sulfide	105-121	cystathionine beta-synthase	Homo sapiens	167-194
34756996-4	2022	H2S is produced by the catalytic activity of cystathionine-beta-synthase (CBS), which is under the regulation of miRNAs.	Deuterium	0-3	cystathionine beta-synthase	Homo sapiens	45-72
34756996-4	2022	H2S is produced by the catalytic activity of cystathionine-beta-synthase (CBS), which is under the regulation of miRNAs.	Deuterium	0-3	cystathionine beta-synthase	Homo sapiens	74-77
34756996-7	2022	Furthermore, transfecting SH-SY5Y cells with miRNA agomir (agonist) and antagomir (antagonist) by lipofectamin RNAiMAX, we further validated miR-203 as a direct regulator of CBS.	lipofectamin	98-110	cystathionine beta-synthase	Homo sapiens	174-177
34914693-4	2021	In particular, we add the polyamine drain on S-adenosyl methionine and the direct effects of estradiol on the enzymes cystathionine beta-synthase (CBS), thymidylate synthase (TS), and dihydrofolate reductase (DHFR).	Estradiol	93-102	cystathionine beta-synthase	Homo sapiens	118-145
34914693-4	2021	In particular, we add the polyamine drain on S-adenosyl methionine and the direct effects of estradiol on the enzymes cystathionine beta-synthase (CBS), thymidylate synthase (TS), and dihydrofolate reductase (DHFR).	Estradiol	93-102	cystathionine beta-synthase	Homo sapiens	147-150
34925701-2	2021	Cysthionine-beta-synthase (CBS) is a key coenzyme in GSH synthesis, and its deficiency is related to a variety of clinical diseases.	Glutathione	53-56	cystathionine beta-synthase	Homo sapiens	27-30
34925701-6	2021	Furthermore, EX-527 (a specific inhibitor of SIRT1) exposure counteracted the protective effect of VB 12 by promoting oxidative stress and aggravating mitochondrial damage without influencing CBS, indicating that vitamin B12 regulates SIRT1 to improve pancreatical damage by activating CBS.	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	13-19	cystathionine beta-synthase	Homo sapiens	286-289
34925701-6	2021	Furthermore, EX-527 (a specific inhibitor of SIRT1) exposure counteracted the protective effect of VB 12 by promoting oxidative stress and aggravating mitochondrial damage without influencing CBS, indicating that vitamin B12 regulates SIRT1 to improve pancreatical damage by activating CBS.	vb 12	99-104	cystathionine beta-synthase	Homo sapiens	286-289
34925701-6	2021	Furthermore, EX-527 (a specific inhibitor of SIRT1) exposure counteracted the protective effect of VB 12 by promoting oxidative stress and aggravating mitochondrial damage without influencing CBS, indicating that vitamin B12 regulates SIRT1 to improve pancreatical damage by activating CBS.	Vitamin B 12	213-224	cystathionine beta-synthase	Homo sapiens	286-289
34320879-10	2021	Drug response prediction suggested that patients with low CBS expression showed high drug sensitivity to 5-Fluorouracil.	Fluorouracil	105-119	cystathionine beta-synthase	Homo sapiens	58-61
34476429-11	2021	The data also showed that the CBS/H2S system implicated in the process of ESCC and DRE inhibited the CBS/H2S system.	Deuterium	34-37	cystathionine beta-synthase	Homo sapiens	30-33
34636997-2	2021	Cystathionine beta-synthase (CBS) deficiency is an example of an IEM that causes large elevations of blood total homocysteine levels, resulting in phenotypes in several tissues.	Homocysteine	113-125	cystathionine beta-synthase	Homo sapiens	0-27
34476429-11	2021	The data also showed that the CBS/H2S system implicated in the process of ESCC and DRE inhibited the CBS/H2S system.	Deuterium	34-37	cystathionine beta-synthase	Homo sapiens	101-104
34476429-11	2021	The data also showed that the CBS/H2S system implicated in the process of ESCC and DRE inhibited the CBS/H2S system.	Deuterium	105-108	cystathionine beta-synthase	Homo sapiens	30-33
34476429-11	2021	The data also showed that the CBS/H2S system implicated in the process of ESCC and DRE inhibited the CBS/H2S system.	Deuterium	105-108	cystathionine beta-synthase	Homo sapiens	101-104
34476429-13	2021	Therefore, DRE may affect ESCC progression through the regulation of PI3K/Akt and Ras/Raf/ERK signal pathways as well as the endogenous CBS/H2S system, and consequently, serve as an effective anti-cancer alternative for human ESCC treatment.	Deuterium	140-143	cystathionine beta-synthase	Homo sapiens	136-139
34368864-2	2021	Cystathionine-beta-synthase, cystathionine-gamma-lyase and cysteine transaminase/3-mercaptopyruvate sulphotransferase are important enzymes involved H2S production in vivo, and the mitochondria are the primary sites of metabolism.	Deuterium	149-152	cystathionine beta-synthase	Homo sapiens	0-27
34568401-4	2021	A deficiency in CBS can lead to elevated levels of homocysteine (HCY) and possible depletion of methionine and/or cysteine.	Homocysteine	51-63	cystathionine beta-synthase	Homo sapiens	16-19
34604137-1	2021	CNNM2 (Cystathionine-beta-synthase-pair Domain Divalent Metal Cation Transport Mediator 2) pathogenic variants have been reported to cause hypomagnesemia, epilepsy, and intellectual disability/developmental delay (ID/DD).	Metals	56-61	cystathionine beta-synthase	Homo sapiens	7-34
34568401-4	2021	A deficiency in CBS can lead to elevated levels of homocysteine (HCY) and possible depletion of methionine and/or cysteine.	Homocysteine	65-68	cystathionine beta-synthase	Homo sapiens	16-19
34568401-4	2021	A deficiency in CBS can lead to elevated levels of homocysteine (HCY) and possible depletion of methionine and/or cysteine.	Methionine	96-106	cystathionine beta-synthase	Homo sapiens	16-19
34568401-4	2021	A deficiency in CBS can lead to elevated levels of homocysteine (HCY) and possible depletion of methionine and/or cysteine.	Cysteine	114-122	cystathionine beta-synthase	Homo sapiens	16-19
34495791-1	2021	Human cystathionine beta-synthase (hCBS) is a Heme-containing, unique pyridoxal 5"-phosphate (PLP) dependent enzyme.	Heme	46-50	cystathionine beta-synthase	Homo sapiens	6-33
34495791-1	2021	Human cystathionine beta-synthase (hCBS) is a Heme-containing, unique pyridoxal 5"-phosphate (PLP) dependent enzyme.	Heme	46-50	cystathionine beta-synthase	Homo sapiens	35-39
34495791-1	2021	Human cystathionine beta-synthase (hCBS) is a Heme-containing, unique pyridoxal 5"-phosphate (PLP) dependent enzyme.	Pyridoxal Phosphate	70-92	cystathionine beta-synthase	Homo sapiens	6-33
34458274-9	2021	However, the relative contributions of each of these enzymes (CBS/CSE/MpST) on cysteine-derived ATP synthesis under hypoxia remains unclear, due to the lack of specific inhibitors.	Cysteine	79-87	cystathionine beta-synthase	Homo sapiens	62-65
34495791-1	2021	Human cystathionine beta-synthase (hCBS) is a Heme-containing, unique pyridoxal 5"-phosphate (PLP) dependent enzyme.	Pyridoxal Phosphate	70-92	cystathionine beta-synthase	Homo sapiens	35-39
34495791-1	2021	Human cystathionine beta-synthase (hCBS) is a Heme-containing, unique pyridoxal 5"-phosphate (PLP) dependent enzyme.	Pyridoxal Phosphate	94-97	cystathionine beta-synthase	Homo sapiens	6-33
34495791-1	2021	Human cystathionine beta-synthase (hCBS) is a Heme-containing, unique pyridoxal 5"-phosphate (PLP) dependent enzyme.	Pyridoxal Phosphate	94-97	cystathionine beta-synthase	Homo sapiens	35-39
34458274-6	2021	Cysteine degradation depends on the action of the H2S-synthesizing enzymes cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and/or 3-mercaptopyruvate sulfurtransferase (MpST; together with cysteine aminotransferase, CAT).	Cysteine	0-8	cystathionine beta-synthase	Homo sapiens	75-102
34573023-4	2021	In human physiology, the transsulfuration enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) are prominent H2S enzymatic sources.	Deuterium	134-137	cystathionine beta-synthase	Homo sapiens	50-77
34573023-4	2021	In human physiology, the transsulfuration enzymes cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE) are prominent H2S enzymatic sources.	Deuterium	134-137	cystathionine beta-synthase	Homo sapiens	79-82
34573023-5	2021	While CBS is known to be inhibited by NO and CO, little is known about CSE regulation by gasotransmitters.	Carbon Monoxide	45-47	cystathionine beta-synthase	Homo sapiens	6-9
34458274-6	2021	Cysteine degradation depends on the action of the H2S-synthesizing enzymes cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and/or 3-mercaptopyruvate sulfurtransferase (MpST; together with cysteine aminotransferase, CAT).	Cysteine	0-8	cystathionine beta-synthase	Homo sapiens	104-107
34458274-9	2021	However, the relative contributions of each of these enzymes (CBS/CSE/MpST) on cysteine-derived ATP synthesis under hypoxia remains unclear, due to the lack of specific inhibitors.	Adenosine Triphosphate	96-99	cystathionine beta-synthase	Homo sapiens	62-65
34458274-6	2021	Cysteine degradation depends on the action of the H2S-synthesizing enzymes cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and/or 3-mercaptopyruvate sulfurtransferase (MpST; together with cysteine aminotransferase, CAT).	Deuterium	50-53	cystathionine beta-synthase	Homo sapiens	75-102
33949005-4	2021	However, adult Cbs null mice that express a hypomorphic allele of human CBS as a transgene (Tg-I278T Cbs-/- ) show almost no neonatal lethality despite having serum tHcy levels similar to mice with no CBS activity.	thcy	165-169	cystathionine beta-synthase	Homo sapiens	72-75
34458274-6	2021	Cysteine degradation depends on the action of the H2S-synthesizing enzymes cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and/or 3-mercaptopyruvate sulfurtransferase (MpST; together with cysteine aminotransferase, CAT).	Deuterium	50-53	cystathionine beta-synthase	Homo sapiens	104-107
34458274-7	2021	In normoxia, CBS and CSE inhibition had a mild impact on cysteine-sustained ATP production, pointing out the relevance of CAT + MpST pathway.	Cysteine	57-65	cystathionine beta-synthase	Homo sapiens	13-16
34458274-7	2021	In normoxia, CBS and CSE inhibition had a mild impact on cysteine-sustained ATP production, pointing out the relevance of CAT + MpST pathway.	Adenosine Triphosphate	76-79	cystathionine beta-synthase	Homo sapiens	13-16
34458274-8	2021	However, in hypoxia, the concomitant inhibition of CBS and CSE had a stronger impact on ATP synthesis, thus also supporting a role of their hydrogen sulfide and/or cysteine persulfide-synthesizing activity in this stressful condition.	Adenosine Triphosphate	88-91	cystathionine beta-synthase	Homo sapiens	51-54
34458274-8	2021	However, in hypoxia, the concomitant inhibition of CBS and CSE had a stronger impact on ATP synthesis, thus also supporting a role of their hydrogen sulfide and/or cysteine persulfide-synthesizing activity in this stressful condition.	Hydrogen Sulfide	140-156	cystathionine beta-synthase	Homo sapiens	51-54
34458274-8	2021	However, in hypoxia, the concomitant inhibition of CBS and CSE had a stronger impact on ATP synthesis, thus also supporting a role of their hydrogen sulfide and/or cysteine persulfide-synthesizing activity in this stressful condition.	cysteine persulfide	164-183	cystathionine beta-synthase	Homo sapiens	51-54
34439739-1	2021	Upregulation of hydrogen sulfide (H2S) biosynthesis, at least in part related to the upregulation of cystathionine beta-synthetase (CBS) in cancer cells, serves as a tumor-promoting factor and has emerged as a possible molecular target for antitumor drug development.	Hydrogen Sulfide	16-32	cystathionine beta-synthase	Homo sapiens	132-135
34439739-1	2021	Upregulation of hydrogen sulfide (H2S) biosynthesis, at least in part related to the upregulation of cystathionine beta-synthetase (CBS) in cancer cells, serves as a tumor-promoting factor and has emerged as a possible molecular target for antitumor drug development.	Deuterium	34-37	cystathionine beta-synthase	Homo sapiens	132-135
34439739-2	2021	To facilitate future clinical translation, we have synthesized a variety of novel CBS-targeting, esterase-cleavable prodrugs based on the structure of the prototypical CBS inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	182-201	cystathionine beta-synthase	Homo sapiens	82-85
34439739-2	2021	To facilitate future clinical translation, we have synthesized a variety of novel CBS-targeting, esterase-cleavable prodrugs based on the structure of the prototypical CBS inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	182-201	cystathionine beta-synthase	Homo sapiens	168-171
34439739-2	2021	To facilitate future clinical translation, we have synthesized a variety of novel CBS-targeting, esterase-cleavable prodrugs based on the structure of the prototypical CBS inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	203-207	cystathionine beta-synthase	Homo sapiens	82-85
34439739-2	2021	To facilitate future clinical translation, we have synthesized a variety of novel CBS-targeting, esterase-cleavable prodrugs based on the structure of the prototypical CBS inhibitor aminooxyacetic acid (AOAA).	Aminooxyacetic Acid	203-207	cystathionine beta-synthase	Homo sapiens	168-171
34439739-7	2021	Patient-derived xenografts (PDTXs) with higher levels of CBS protein grew significantly larger than tumors with lower levels, and YD0251 treatment inhibited the growth of PDTXs with elevated CBS, whereas it had no significant effect on PDTXs with low CBS protein levels.	yd0251	130-136	cystathionine beta-synthase	Homo sapiens	191-194
34439739-10	2021	Colon cancer cells produced significant levels of lanthionine, a rare metabolic intermediate of CBS-mediated H2S biosynthesis; forced expression of CBS into non-transformed epithelial cells increased lanthionine biogenesis in vitro and in vivo (measured in the urine of tumor-bearing mice).	lanthionine	50-61	cystathionine beta-synthase	Homo sapiens	96-99
34439739-10	2021	Colon cancer cells produced significant levels of lanthionine, a rare metabolic intermediate of CBS-mediated H2S biosynthesis; forced expression of CBS into non-transformed epithelial cells increased lanthionine biogenesis in vitro and in vivo (measured in the urine of tumor-bearing mice).	Deuterium	109-112	cystathionine beta-synthase	Homo sapiens	96-99
34439739-10	2021	Colon cancer cells produced significant levels of lanthionine, a rare metabolic intermediate of CBS-mediated H2S biosynthesis; forced expression of CBS into non-transformed epithelial cells increased lanthionine biogenesis in vitro and in vivo (measured in the urine of tumor-bearing mice).	lanthionine	200-211	cystathionine beta-synthase	Homo sapiens	148-151
34208749-4	2021	In 1996, we demonstrated that hydrogen sulfide (H2S) is a potential signaling molecule, which can be produced by cystathionine beta-synthase (CBS) to modify neurotransmission in the brain.	Hydrogen Sulfide	30-46	cystathionine beta-synthase	Homo sapiens	113-140
34208749-4	2021	In 1996, we demonstrated that hydrogen sulfide (H2S) is a potential signaling molecule, which can be produced by cystathionine beta-synthase (CBS) to modify neurotransmission in the brain.	Deuterium	48-51	cystathionine beta-synthase	Homo sapiens	113-140
35435014-2	2022	Three enzymes are recognized as endogenous sources of H2S in various cells and tissues: cystathionine g-lyase (CSE), cystathionine beta-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST).	Deuterium	54-57	cystathionine beta-synthase	Homo sapiens	117-144
35417765-0	2022	Pyridoxine non-responsive R336C mutation alters the molecular properties of cystathionine beta-synthase leading to severe homocystinuria phenotype.	Pyridoxine	0-10	cystathionine beta-synthase	Homo sapiens	76-103
35605291-4	2022	A modulatory role for the H2S pathway is supported by the finding that, the overexpression of CSE or CBS, but not 3-MST, inhibits cell proliferation and promotes apoptosis.	Deuterium	26-29	cystathionine beta-synthase	Homo sapiens	101-104
35605291-9	2022	In conclusion, in urothelial carcinoma, there is an impairment of H2S pathway that involves CSE and CBS- derived hydrogen sulfide.	Deuterium	66-69	cystathionine beta-synthase	Homo sapiens	100-103
35605291-9	2022	In conclusion, in urothelial carcinoma, there is an impairment of H2S pathway that involves CSE and CBS- derived hydrogen sulfide.	Hydrogen Sulfide	113-129	cystathionine beta-synthase	Homo sapiens	100-103
35618601-3	2022	In the high-CBS expressing tumor cells, CBS, and its product hydrogen sulfide (H2S) serves as a bioenergetic, proliferative, cytoprotective and stemness factor; it also supports angiogenesis and epithelial-to-mesenchymal transition in the cancer microenvironment.	Hydrogen Sulfide	61-77	cystathionine beta-synthase	Homo sapiens	12-15
35618601-3	2022	In the high-CBS expressing tumor cells, CBS, and its product hydrogen sulfide (H2S) serves as a bioenergetic, proliferative, cytoprotective and stemness factor; it also supports angiogenesis and epithelial-to-mesenchymal transition in the cancer microenvironment.	Hydrogen Sulfide	61-77	cystathionine beta-synthase	Homo sapiens	40-43
35618601-3	2022	In the high-CBS expressing tumor cells, CBS, and its product hydrogen sulfide (H2S) serves as a bioenergetic, proliferative, cytoprotective and stemness factor; it also supports angiogenesis and epithelial-to-mesenchymal transition in the cancer microenvironment.	Deuterium	79-82	cystathionine beta-synthase	Homo sapiens	12-15
35618601-3	2022	In the high-CBS expressing tumor cells, CBS, and its product hydrogen sulfide (H2S) serves as a bioenergetic, proliferative, cytoprotective and stemness factor; it also supports angiogenesis and epithelial-to-mesenchymal transition in the cancer microenvironment.	Deuterium	79-82	cystathionine beta-synthase	Homo sapiens	40-43
34994384-2	2022	Previous studies have demonstrated that Cystathionine-beta-synthase (CBS)/H2S system plays important roles in progression of various cancer.	Deuterium	74-77	cystathionine beta-synthase	Homo sapiens	40-67
34994384-2	2022	Previous studies have demonstrated that Cystathionine-beta-synthase (CBS)/H2S system plays important roles in progression of various cancer.	Deuterium	74-77	cystathionine beta-synthase	Homo sapiens	69-72
34994384-10	2022	Moreover, it was demonstrated that H2S derived from CBS activated SIRT1 via increasing the NAD +/NADH ratio and promoting the phosphorylation of SIRT1.	Deuterium	35-38	cystathionine beta-synthase	Homo sapiens	52-55
34994384-10	2022	Moreover, it was demonstrated that H2S derived from CBS activated SIRT1 via increasing the NAD +/NADH ratio and promoting the phosphorylation of SIRT1.	NAD	91-96	cystathionine beta-synthase	Homo sapiens	52-55
34994384-10	2022	Moreover, it was demonstrated that H2S derived from CBS activated SIRT1 via increasing the NAD +/NADH ratio and promoting the phosphorylation of SIRT1.	NAD	97-101	cystathionine beta-synthase	Homo sapiens	52-55
34994384-11	2022	In addition, H2S derived from CBS also enhanced SIRT1 protein stability.	Deuterium	13-16	cystathionine beta-synthase	Homo sapiens	30-33
34994384-12	2022	Taken together, these data show that the high expression of CBS/H2S system promotes ESCC lymph node metastasis via activating SIRT1 signaling pathway and CBS could serve as a potential therapeutic target for clinical intervention in ESCC.	Deuterium	64-67	cystathionine beta-synthase	Homo sapiens	60-63
34994384-12	2022	Taken together, these data show that the high expression of CBS/H2S system promotes ESCC lymph node metastasis via activating SIRT1 signaling pathway and CBS could serve as a potential therapeutic target for clinical intervention in ESCC.	Deuterium	64-67	cystathionine beta-synthase	Homo sapiens	154-157
35581292-10	2022	APOC1 also induced ferroptosis resistance by increasing cystathionine beta-synthase (CBS) expression, which promoted trans-sulfuration and increased GSH synthesis, ultimately leading to an increase in glutathione peroxidase-4 (GPX4).	Glutathione	149-152	cystathionine beta-synthase	Homo sapiens	56-83
35581292-10	2022	APOC1 also induced ferroptosis resistance by increasing cystathionine beta-synthase (CBS) expression, which promoted trans-sulfuration and increased GSH synthesis, ultimately leading to an increase in glutathione peroxidase-4 (GPX4).	Glutathione	149-152	cystathionine beta-synthase	Homo sapiens	85-88
35435014-2	2022	Three enzymes are recognized as endogenous sources of H2S in various cells and tissues: cystathionine g-lyase (CSE), cystathionine beta-synthase (CBS) and 3-mercaptopyruvate sulfurtransferase (3-MST).	Deuterium	54-57	cystathionine beta-synthase	Homo sapiens	146-149
35426918-4	2022	The remnant LITA and radial artery were collected to measure the expression levels of three H2S-producing enzymes: cystathionine beta-synthase, cystathionine gamma-lyase and 3-mercaptopyruvate sulfurtransferase using quantitative real-time polymerase chain reaction.	Deuterium	92-95	cystathionine beta-synthase	Homo sapiens	115-142
35174476-2	2022	H2S is synthesized by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (MST).	Deuterium	0-3	cystathionine beta-synthase	Homo sapiens	22-49
35174476-2	2022	H2S is synthesized by cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (MST).	Deuterium	0-3	cystathionine beta-synthase	Homo sapiens	51-54
35174317-10	2022	Furthermore, we demonstrate that MYCN-amplified NB cell lines and tumors have higher levels of cystathionine beta-synthase (CBS), the rate-limiting enzyme in transsulfuration, which leads to higher levels of the thioether cystathionine (R-S-(2-amino-2-carboxyethyl)-l-homocysteine).	thioether cystathionine	212-235	cystathionine beta-synthase	Homo sapiens	95-122
35174317-10	2022	Furthermore, we demonstrate that MYCN-amplified NB cell lines and tumors have higher levels of cystathionine beta-synthase (CBS), the rate-limiting enzyme in transsulfuration, which leads to higher levels of the thioether cystathionine (R-S-(2-amino-2-carboxyethyl)-l-homocysteine).	thioether cystathionine	212-235	cystathionine beta-synthase	Homo sapiens	124-127
35174317-10	2022	Furthermore, we demonstrate that MYCN-amplified NB cell lines and tumors have higher levels of cystathionine beta-synthase (CBS), the rate-limiting enzyme in transsulfuration, which leads to higher levels of the thioether cystathionine (R-S-(2-amino-2-carboxyethyl)-l-homocysteine).	r-s-(2-amino-2-carboxyethyl)-l-homocysteine	237-280	cystathionine beta-synthase	Homo sapiens	95-122
35174317-10	2022	Furthermore, we demonstrate that MYCN-amplified NB cell lines and tumors have higher levels of cystathionine beta-synthase (CBS), the rate-limiting enzyme in transsulfuration, which leads to higher levels of the thioether cystathionine (R-S-(2-amino-2-carboxyethyl)-l-homocysteine).	r-s-(2-amino-2-carboxyethyl)-l-homocysteine	237-280	cystathionine beta-synthase	Homo sapiens	124-127
35114314-4	2022	In the present study, the NaHSO3 treatments markedly increased the homocysteine (Hcy) level but decreased the cysteine (Cys) level by promoting the expression of Hcy synthase and inhibiting the activities of cystathionine beta-synthase and cystathionine gamma-lyase in NCM460 cells.	sodium hydrogen sulfite	26-32	cystathionine beta-synthase	Homo sapiens	208-235
35114314-4	2022	In the present study, the NaHSO3 treatments markedly increased the homocysteine (Hcy) level but decreased the cysteine (Cys) level by promoting the expression of Hcy synthase and inhibiting the activities of cystathionine beta-synthase and cystathionine gamma-lyase in NCM460 cells.	Cysteine	110-118	cystathionine beta-synthase	Homo sapiens	208-235
35114314-4	2022	In the present study, the NaHSO3 treatments markedly increased the homocysteine (Hcy) level but decreased the cysteine (Cys) level by promoting the expression of Hcy synthase and inhibiting the activities of cystathionine beta-synthase and cystathionine gamma-lyase in NCM460 cells.	Cysteine	120-123	cystathionine beta-synthase	Homo sapiens	208-235
35157853-1	2022	Besides its presence in the liver, brain, pancreas, and kidney, Cystathionine beta-Synthase (CBS) is also found in many other tissues, where it acts through regulation of hydrogen sulfide (H2S) generation and homocysteine (Hcy) metabolism, to interact with other molecules during hypoxia and ischemia/reperfusion (I/R).	Hydrogen Sulfide	171-187	cystathionine beta-synthase	Homo sapiens	64-91
35157853-1	2022	Besides its presence in the liver, brain, pancreas, and kidney, Cystathionine beta-Synthase (CBS) is also found in many other tissues, where it acts through regulation of hydrogen sulfide (H2S) generation and homocysteine (Hcy) metabolism, to interact with other molecules during hypoxia and ischemia/reperfusion (I/R).	Hydrogen Sulfide	171-187	cystathionine beta-synthase	Homo sapiens	93-96
35157853-1	2022	Besides its presence in the liver, brain, pancreas, and kidney, Cystathionine beta-Synthase (CBS) is also found in many other tissues, where it acts through regulation of hydrogen sulfide (H2S) generation and homocysteine (Hcy) metabolism, to interact with other molecules during hypoxia and ischemia/reperfusion (I/R).	Deuterium	189-192	cystathionine beta-synthase	Homo sapiens	64-91
35157853-1	2022	Besides its presence in the liver, brain, pancreas, and kidney, Cystathionine beta-Synthase (CBS) is also found in many other tissues, where it acts through regulation of hydrogen sulfide (H2S) generation and homocysteine (Hcy) metabolism, to interact with other molecules during hypoxia and ischemia/reperfusion (I/R).	Deuterium	189-192	cystathionine beta-synthase	Homo sapiens	93-96
35157853-1	2022	Besides its presence in the liver, brain, pancreas, and kidney, Cystathionine beta-Synthase (CBS) is also found in many other tissues, where it acts through regulation of hydrogen sulfide (H2S) generation and homocysteine (Hcy) metabolism, to interact with other molecules during hypoxia and ischemia/reperfusion (I/R).	Homocysteine	209-221	cystathionine beta-synthase	Homo sapiens	64-91
35157853-1	2022	Besides its presence in the liver, brain, pancreas, and kidney, Cystathionine beta-Synthase (CBS) is also found in many other tissues, where it acts through regulation of hydrogen sulfide (H2S) generation and homocysteine (Hcy) metabolism, to interact with other molecules during hypoxia and ischemia/reperfusion (I/R).	Homocysteine	209-221	cystathionine beta-synthase	Homo sapiens	93-96
35157853-1	2022	Besides its presence in the liver, brain, pancreas, and kidney, Cystathionine beta-Synthase (CBS) is also found in many other tissues, where it acts through regulation of hydrogen sulfide (H2S) generation and homocysteine (Hcy) metabolism, to interact with other molecules during hypoxia and ischemia/reperfusion (I/R).	Homocysteine	223-226	cystathionine beta-synthase	Homo sapiens	64-91
35157853-1	2022	Besides its presence in the liver, brain, pancreas, and kidney, Cystathionine beta-Synthase (CBS) is also found in many other tissues, where it acts through regulation of hydrogen sulfide (H2S) generation and homocysteine (Hcy) metabolism, to interact with other molecules during hypoxia and ischemia/reperfusion (I/R).	Homocysteine	223-226	cystathionine beta-synthase	Homo sapiens	93-96
35172821-0	2022	Overexpression of CBS/H2S inhibits proliferation and metastasis of colon cancer cells through downregulation of CD44.	Deuterium	22-25	cystathionine beta-synthase	Homo sapiens	18-21
35172821-3	2022	We hypothesized that overexpression of cystathionine-beta-synthase (CBS)/H2S exerts an inhibitory effect on colon cancer cell proliferation and metastasis.	Deuterium	73-76	cystathionine beta-synthase	Homo sapiens	39-66
35172821-3	2022	We hypothesized that overexpression of cystathionine-beta-synthase (CBS)/H2S exerts an inhibitory effect on colon cancer cell proliferation and metastasis.	Deuterium	73-76	cystathionine beta-synthase	Homo sapiens	68-71
35172821-12	2022	Furthermore, CD44 and the transcription factor SP-1 was probably involved in the inhibitory effect of CBS/H2S axis on colon cancer cells.	Deuterium	106-109	cystathionine beta-synthase	Homo sapiens	102-105
35204244-8	2022	Interestingly, IS downregulated the H2S-producing enzymes cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST), and these effects could be reversed by inhibition of the IS receptor, aryl hydrocarbon receptor (AhR).	Deuterium	36-39	cystathionine beta-synthase	Homo sapiens	58-85
35204244-8	2022	Interestingly, IS downregulated the H2S-producing enzymes cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST), and these effects could be reversed by inhibition of the IS receptor, aryl hydrocarbon receptor (AhR).	Deuterium	36-39	cystathionine beta-synthase	Homo sapiens	87-90