PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
23690971-3	2013	We now show that C24- and C16-ceramides are the most abundant lung ceramide species, paralleled by high expression of their synthetic enzymes, ceramide synthase 2 (CerS2) and CerS5, respectively.	c24- and c16-ceramides	17-39	ceramide synthase 5	Mus musculus	175-180
26853464-8	2016	We found a strong impact of CerS5-dependent ceramide synthesis in white adipose tissue after high fat diet feeding.	Ceramides	44-52	ceramide synthase 5	Mus musculus	28-33
25383881-7	2014	Furthermore, FB1 treatment disturbed the gene expression of sphingolipid metabolism enzymes (longevity assurance homolog 5, LASS 5; sphingosine kinase 1, Sphk1; sphingosine kinase 2, Sphk2; sphingosine 1- phosphate lyase, Sgpl1; sphingosine 1-phosphate phosphatase, Sgpp1) in the maternal liver, uterus, fetus, and placenta, but NSP administration reversed the perturbations.	Sphingolipids	60-72	ceramide synthase 5	Mus musculus	93-122
23690971-3	2013	We now show that C24- and C16-ceramides are the most abundant lung ceramide species, paralleled by high expression of their synthetic enzymes, ceramide synthase 2 (CerS2) and CerS5, respectively.	Ceramides	30-38	ceramide synthase 5	Mus musculus	175-180
23690971-4	2013	Furthermore, the ceramide species synthesis in the lung is homeostatically regulated, since mice lacking very long acyl chain C24-ceramides due to genetic deficiency of CerS2 displayed a ten-fold increase in C16-ceramides and C16-dihydroceramides along with elevation of acid sphingomyelinase and CerS5 activities.	Ceramides	17-25	ceramide synthase 5	Mus musculus	297-302
23690971-4	2013	Furthermore, the ceramide species synthesis in the lung is homeostatically regulated, since mice lacking very long acyl chain C24-ceramides due to genetic deficiency of CerS2 displayed a ten-fold increase in C16-ceramides and C16-dihydroceramides along with elevation of acid sphingomyelinase and CerS5 activities.	c24-ceramides	126-139	ceramide synthase 5	Mus musculus	297-302
34914638-4	2022	It was first found by us that miR-148a deficiency dramatically increased mouse gut dysbiosis through upregulating Cers5 expression, which promoted ceramide synthesis afterward.	Ceramides	147-155	ceramide synthase 5	Mus musculus	114-119
16987101-5	2007	Ceramide synthase activity of 4Delta.Lass5 cells only utilizes C16 and C18 fatty acids and does not require the help of Lip1p, an essential cofactor of Lag1p/Lac1p.	Fatty Acids	75-86	ceramide synthase 5	Mus musculus	37-42
16987101-6	2007	HPLC-electrospray ionization-MS/MS analysis demonstrated that in IPCs (inositolphosphorylceramides) of 4Delta.Lass5, the very long chain fatty acids (C26 and C24) account for <1% instead of the normal >97%.	inositolphosphorylceramide	71-98	ceramide synthase 5	Mus musculus	110-115
16987101-6	2007	HPLC-electrospray ionization-MS/MS analysis demonstrated that in IPCs (inositolphosphorylceramides) of 4Delta.Lass5, the very long chain fatty acids (C26 and C24) account for <1% instead of the normal >97%.	4delta	103-109	ceramide synthase 5	Mus musculus	110-115
16987101-6	2007	HPLC-electrospray ionization-MS/MS analysis demonstrated that in IPCs (inositolphosphorylceramides) of 4Delta.Lass5, the very long chain fatty acids (C26 and C24) account for <1% instead of the normal >97%.	chain fatty acids	131-148	ceramide synthase 5	Mus musculus	110-115
16987101-7	2007	Notwithstanding, IPCs incorporated into glycosylphosphatidylinositol anchors of 4Delta.Lass5 show normal mobility on TLC and the ceramide- and raft-dependent traffic of Gas1p (glycophospholipid-anchored surface protein) from endoplasmic reticulum to Golgi remains almost normal.	Glycosylphosphatidylinositols	40-68	ceramide synthase 5	Mus musculus	87-92
16987101-7	2007	Notwithstanding, IPCs incorporated into glycosylphosphatidylinositol anchors of 4Delta.Lass5 show normal mobility on TLC and the ceramide- and raft-dependent traffic of Gas1p (glycophospholipid-anchored surface protein) from endoplasmic reticulum to Golgi remains almost normal.	Ceramides	129-137	ceramide synthase 5	Mus musculus	87-92
16987101-7	2007	Notwithstanding, IPCs incorporated into glycosylphosphatidylinositol anchors of 4Delta.Lass5 show normal mobility on TLC and the ceramide- and raft-dependent traffic of Gas1p (glycophospholipid-anchored surface protein) from endoplasmic reticulum to Golgi remains almost normal.	glycophospholipid	176-193	ceramide synthase 5	Mus musculus	87-92
31692231-0	2020	A tissue-specific screen of ceramide expression in aged mice identifies ceramide synthase-1 and ceramide synthase-5 as potential regulators of fiber size and strength in skeletal muscle.	Ceramides	28-36	ceramide synthase 5	Mus musculus	96-115
32630271-0	2020	Ceramide Synthase 5 Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis and Colon Carcinogenesis and Impairs T-Cell Activation.	dextran sodium sulfate	42-64	ceramide synthase 5	Mus musculus	0-19
32630271-1	2020	Ceramide synthase 5 is one of six enzymes that catalyze the production of ceramides from sphingosine or sphinganine.	Ceramides	74-83	ceramide synthase 5	Mus musculus	0-19
32630271-1	2020	Ceramide synthase 5 is one of six enzymes that catalyze the production of ceramides from sphingosine or sphinganine.	Sphingosine	89-100	ceramide synthase 5	Mus musculus	0-19
32630271-1	2020	Ceramide synthase 5 is one of six enzymes that catalyze the production of ceramides from sphingosine or sphinganine.	safingol	104-115	ceramide synthase 5	Mus musculus	0-19
32630271-11	2020	In summary, we show that CerS5-ko mice were more susceptible to dextran sodium sulfate-induced colitis and azoxymethane/dextran sodium sulfate-induced colitis-associated colon cancer.	dextran sodium sulfate	64-86	ceramide synthase 5	Mus musculus	25-30
32630271-11	2020	In summary, we show that CerS5-ko mice were more susceptible to dextran sodium sulfate-induced colitis and azoxymethane/dextran sodium sulfate-induced colitis-associated colon cancer.	Azoxymethane	107-119	ceramide synthase 5	Mus musculus	25-30
32630271-11	2020	In summary, we show that CerS5-ko mice were more susceptible to dextran sodium sulfate-induced colitis and azoxymethane/dextran sodium sulfate-induced colitis-associated colon cancer.	dextran sodium sulfate	120-142	ceramide synthase 5	Mus musculus	25-30
31692231-4	2020	Consistently, the expression of CerS1 and CerS5 mRNA, encoding the ceramide synthases (CerS) with substrate preference for C16:0 and C18:0 acyl chains, respectively, was down-regulated in skeletal muscle of aged mice.	Ceramides	67-75	ceramide synthase 5	Mus musculus	42-47
31692231-4	2020	Consistently, the expression of CerS1 and CerS5 mRNA, encoding the ceramide synthases (CerS) with substrate preference for C16:0 and C18:0 acyl chains, respectively, was down-regulated in skeletal muscle of aged mice.	Acyl Coenzyme A	139-143	ceramide synthase 5	Mus musculus	42-47
30605666-6	2019	In contrast, muscle-specific deficiency of C16:0 ceramide-producing CerS5 and CerS6 failed to protect mice from obesity-induced insulin resistance.	Ceramides	49-57	ceramide synthase 5	Mus musculus	68-73
29127192-4	2018	In a mouse model of diabetic cardiomyopathy, sphingolipid profiling revealed increases in not only the CerS5-derived ceramides but also in very long chain (VLC) ceramides derived from CerS2.	Sphingolipids	45-57	ceramide synthase 5	Mus musculus	103-108
29127192-4	2018	In a mouse model of diabetic cardiomyopathy, sphingolipid profiling revealed increases in not only the CerS5-derived ceramides but also in very long chain (VLC) ceramides derived from CerS2.	Ceramides	117-126	ceramide synthase 5	Mus musculus	103-108
29109103-10	2017	Transcriptional analysis revealed 4 important genes involved in sphingolipid metabolism to be deregulated in HNF1A deficiency: Ormdl1, sphingosine kinase-2, neutral ceramidase, and ceramide synthase-5.	Sphingolipids	64-76	ceramide synthase 5	Mus musculus	181-200
29507106-4	2018	In this study, we demonstrate that substitution of the nonanchoring position 3 into a proline residue of the first identified TEIPP peptide, the murine Trh4, results in significantly enhanced recognition by antitumor CTLs toward the wild-type epitope.	Proline	86-93	ceramide synthase 5	Mus musculus	152-156