PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
32483833-0	2020	LncRNA-ES3 inhibition by Bhlhe40 is involved in high glucose-induced calcification/senescence of vascular smooth muscle cells.	Glucose	53-60	basic helix-loop-helix family member e40	Homo sapiens	25-32
35352891-0	2022	MiR-494-3p Upregulation Exacerbates Cerebral Ischemia Injury by Targeting Bhlhe40.	mir-494-3p	0-10	basic helix-loop-helix family member e40	Homo sapiens	74-81
35352891-10	2022	Bhlhe40 overexpression inhibited cell apoptosis and reduced ROS production in SH-SY5Y cells after OGD/R treatment.	Reactive Oxygen Species	60-63	basic helix-loop-helix family member e40	Homo sapiens	0-7
35352891-13	2022	Rescue experiments suggested that Bhlhe40 could reverse the effects of miR-494-3p overexpression on ROS production and cell apoptosis.	mir-494-3p	71-81	basic helix-loop-helix family member e40	Homo sapiens	34-41
35352891-13	2022	Rescue experiments suggested that Bhlhe40 could reverse the effects of miR-494-3p overexpression on ROS production and cell apoptosis.	Reactive Oxygen Species	100-103	basic helix-loop-helix family member e40	Homo sapiens	34-41
35352891-14	2022	CONCLUSION: MiR-494-3p exacerbates brain injury and neuronal injury by regulating Bhlhe40 after I/R.	mir-494-3p	12-22	basic helix-loop-helix family member e40	Homo sapiens	82-89
32483833-4	2020	Here, we report that the expression of basic helix-loop-helix family member e40 (Bhlhe40) was decreased significantly in HA-VSMCs treated with high glucose, whereas the expression of basic leucine zipper transcription factor (BATF) was increased.	Glucose	148-155	basic helix-loop-helix family member e40	Homo sapiens	39-79
32483833-4	2020	Here, we report that the expression of basic helix-loop-helix family member e40 (Bhlhe40) was decreased significantly in HA-VSMCs treated with high glucose, whereas the expression of basic leucine zipper transcription factor (BATF) was increased.	Glucose	148-155	basic helix-loop-helix family member e40	Homo sapiens	81-88
32483833-5	2020	Overexpression of Bhlhe40 and inhibition of BATF alleviated calcification/senescence of HA-VSMCs, as confirmed by Alizarin Red S staining and the presence of senescence-associated beta-galactosidase-positive cells.	Alizarin Red S	114-128	basic helix-loop-helix family member e40	Homo sapiens	18-25
30391825-4	2019	Mitochondrial efficiency was significantly reduced by Bhlhe40 knockdown, resulting in the burst of ROS.	ros	99-102	basic helix-loop-helix family member e40	Homo sapiens	54-61
32577154-3	2020	As a transcription factor, BHLHE40 is expressed in the nucleus, where it binds to target gene promoters containing the E-box hexanucleotide sequence, but can also be expressed in the cytoplasm, where it stabilizes cyclin E, preventing cyclin E-mediated DNA replication and cell cycle progression.	hexanucleotide	125-139	basic helix-loop-helix family member e40	Homo sapiens	27-34
30391825-5	2019	Over-expression of a constitutively active PGC-1alpha-interactive domain (named as VBH135) of Bhlhe40 mimicked the effects of its knockdown on peroxisomes but simultaneously reduced ROS level.	ros	182-185	basic helix-loop-helix family member e40	Homo sapiens	94-101
30391825-7	2019	Unsaturated fatty acid oxidation, insulin response, and oxidative respiration were highly enhanced in Bhlhe40 knockdown or VBH135 over-expressed cells, suggesting the importance of Bhlhe40 in the regulation of unsaturated fatty acid and glucose oxidative metabolism.	Fatty Acids, Unsaturated	0-22	basic helix-loop-helix family member e40	Homo sapiens	102-109
30391825-7	2019	Unsaturated fatty acid oxidation, insulin response, and oxidative respiration were highly enhanced in Bhlhe40 knockdown or VBH135 over-expressed cells, suggesting the importance of Bhlhe40 in the regulation of unsaturated fatty acid and glucose oxidative metabolism.	Fatty Acids, Unsaturated	210-232	basic helix-loop-helix family member e40	Homo sapiens	102-109
30391825-7	2019	Unsaturated fatty acid oxidation, insulin response, and oxidative respiration were highly enhanced in Bhlhe40 knockdown or VBH135 over-expressed cells, suggesting the importance of Bhlhe40 in the regulation of unsaturated fatty acid and glucose oxidative metabolism.	Fatty Acids, Unsaturated	210-232	basic helix-loop-helix family member e40	Homo sapiens	181-188
30391825-7	2019	Unsaturated fatty acid oxidation, insulin response, and oxidative respiration were highly enhanced in Bhlhe40 knockdown or VBH135 over-expressed cells, suggesting the importance of Bhlhe40 in the regulation of unsaturated fatty acid and glucose oxidative metabolism.	Glucose	237-244	basic helix-loop-helix family member e40	Homo sapiens	102-109
30391825-7	2019	Unsaturated fatty acid oxidation, insulin response, and oxidative respiration were highly enhanced in Bhlhe40 knockdown or VBH135 over-expressed cells, suggesting the importance of Bhlhe40 in the regulation of unsaturated fatty acid and glucose oxidative metabolism.	Glucose	237-244	basic helix-loop-helix family member e40	Homo sapiens	181-188
25963661-3	2015	Here we found that PGC-1alpha directly interacted with Bhlhe40, a basic helix-loop-helix (bHLH) transcriptional repressor induced by hypoxia, and protects SKM from ROS damage, and they cooccupied PGC-1alpha-targeted gene promoters/enhancers, which in turn repressed PGC-1alpha transactivational activity.	ros	164-167	basic helix-loop-helix family member e40	Homo sapiens	55-62
29580070-12	2018	Furthermore, relevant correlations (p < 0.05) between methylation at cg09578018 (RORA) and cg01180628 (BHLHE40) with total energy and carbohydrate intakes were found.	cg09578018	72-82	basic helix-loop-helix family member e40	Homo sapiens	106-113
29580070-12	2018	Furthermore, relevant correlations (p < 0.05) between methylation at cg09578018 (RORA) and cg01180628 (BHLHE40) with total energy and carbohydrate intakes were found.	Carbohydrates	137-149	basic helix-loop-helix family member e40	Homo sapiens	106-113
26967585-9	2016	Stimulated by retinoic acid 13 (STRA13), presenilin enhancer gamma secretase subunit (PSENEN), and nucleosome assembly protein 1-like 2 (NAP1L2) were significantly enriched by integration analysis of the co-expression and regulatory network.	retinoic acid 13	14-30	basic helix-loop-helix family member e40	Homo sapiens	32-38
25963661-5	2015	Knockdown of Bhlhe40 mRNA increased levels of ROS, fatty acid oxidation, mitochondrial DNA, and expression of PGC-1alpha target genes.	ros	46-49	basic helix-loop-helix family member e40	Homo sapiens	13-20
25963661-5	2015	Knockdown of Bhlhe40 mRNA increased levels of ROS, fatty acid oxidation, mitochondrial DNA, and expression of PGC-1alpha target genes.	Fatty Acids	51-61	basic helix-loop-helix family member e40	Homo sapiens	13-20
20863812-1	2010	AIMS: The cyclic adenosine monophosphate-inducible basic helix-loop-helix (bHLH) domain containing class-B2 transcriptional factor BHLHB2 is differentially expressed in a number of human malignancies.	Cyclic AMP	10-40	basic helix-loop-helix family member e40	Homo sapiens	131-137
23518061-8	2013	Using the novel functional interpolating single-nucleotide polymorphisms bioinformatics approach, we identified 6 Moyamoya Disease-associated autoantibodies against APP, GPS1, STRA13, CTNNB1, ROR1 and EDIL3.	single-nucleotide	41-58	basic helix-loop-helix family member e40	Homo sapiens	176-182
22905217-4	2012	Mutation of SUMO acceptor lysines 159 and 279 located in the C-terminal repression domain has no impact on nuclear localization; however, it abrogates association with the co-repressor histone deacetylase 1 (HDAC1), attenuates repression of cyclin D1, and prevents Stra13-mediated growth suppression.	Lysine	26-33	basic helix-loop-helix family member e40	Homo sapiens	265-271
20863812-8	2010	BHLHB2 silencing with RNAi had no significant effects on growth and invasion but increased apoptosis resistance against gemcitabine by reducing caspace-3 cleavage.	gemcitabine	120-131	basic helix-loop-helix family member e40	Homo sapiens	0-6
20863812-9	2010	In BHLHB2 silenced cells the ED50 of gemcitabine increased from 13.95 +- 1.353 to 38.70 +- 5.262 nM (p<0.05).	gemcitabine	37-48	basic helix-loop-helix family member e40	Homo sapiens	3-9
20863812-13	2010	CONCLUSIONS: Hypoxia-inducible BHLHB2 expression is a novel independent prognostic marker in pancreatic cancer patients and indicates increased chemosensitivity towards gemcitabine.	gemcitabine	169-180	basic helix-loop-helix family member e40	Homo sapiens	31-37
15326561-5	2004	Furthermore, cyclic AMP increased the level of enhancer of split- and hairy-related protein-2 mRNA in both cells in an additive manner.	Cyclic AMP	13-23	basic helix-loop-helix family member e40	Homo sapiens	47-93
21233058-5	2010	Ca:Mg rose from largely below 3.0 in 1994-5 to generally above or approaching 3.0 after 2000, coinciding with a sharp 2% rise in type 2 diabetes incidence and prevalence in the USA population and a 1994-2005 rise in colorectal cancer incidence among young white, non-Hispanic adult men and women in the USA.	Magnesium	3-5	basic helix-loop-helix family member e40	Homo sapiens	112-119
18838394-9	2008	By doing so, HIF and its targets, Stra13 and DEC2 reduce the ATP consuming anabolic lipogenesis prior to the actual decrease of ATP acting as a feed-forward mechanism.	Adenosine Triphosphate	61-64	basic helix-loop-helix family member e40	Homo sapiens	34-40
18838394-9	2008	By doing so, HIF and its targets, Stra13 and DEC2 reduce the ATP consuming anabolic lipogenesis prior to the actual decrease of ATP acting as a feed-forward mechanism.	Adenosine Triphosphate	128-131	basic helix-loop-helix family member e40	Homo sapiens	34-40
18342625-3	2008	Here we show that Stra13 and Dec2, two circadian transcriptional regulators which play a crucial role in cell proliferation and apoptosis are overexpressed and no longer rhythmic in serum shocked fibroblasts treated with CoCl(2,) a substitute of hypoxia.	cobaltous chloride	221-228	basic helix-loop-helix family member e40	Homo sapiens	18-24
15326561-6	2004	Thus, we conclude that insulin and cyclic AMP induce the expression of the enhancer of split- and hairy-related protein-2 gene in both 3T3-L1 adipocytes and L6 myotubes, and that the gene expression enhanced by insulin is regulated by the cell type-specific pathway.	Cyclic AMP	35-45	basic helix-loop-helix family member e40	Homo sapiens	75-121
12594185-0	2003	Stra13, a prostaglandin E2-induced gene, regulates the cellular redox state of podocytes.	Dinoprostone	10-26	basic helix-loop-helix family member e40	Homo sapiens	0-6
12594185-5	2003	PGE2, forskolin, and retinoic acid induced a time-dependent up-regulation of Stra13 mRNA and protein expression in podocytes.	Dinoprostone	0-4	basic helix-loop-helix family member e40	Homo sapiens	77-83
12594185-5	2003	PGE2, forskolin, and retinoic acid induced a time-dependent up-regulation of Stra13 mRNA and protein expression in podocytes.	Colforsin	6-15	basic helix-loop-helix family member e40	Homo sapiens	77-83
12594185-5	2003	PGE2, forskolin, and retinoic acid induced a time-dependent up-regulation of Stra13 mRNA and protein expression in podocytes.	Tretinoin	21-34	basic helix-loop-helix family member e40	Homo sapiens	77-83
12594185-7	2003	Compared with control cells, cells overexpressing Stra13 showed markedly reduced NADPH-dependent superoxid anion generation.	NADP	81-86	basic helix-loop-helix family member e40	Homo sapiens	50-56
12594185-10	2003	After stimulation with exogenous ROS, Stra13-overexpressing podocytes were more resistant to oxidative stress than were control cells.	Reactive Oxygen Species	33-36	basic helix-loop-helix family member e40	Homo sapiens	38-44
11278694-5	2001	Similar to many other von Hippel-Lindau tumor-suppressor protein (pVHL) targets, the expression of STRA13 on the mRNA level was hypoxia-sensitive, indicating oxygen-dependent regulation of the gene, presumably through the pVHL/hypoxia-inducible factor 1 (HIF-1) pathway.	Oxygen	158-164	basic helix-loop-helix family member e40	Homo sapiens	99-105
12297495-5	2002	Indeed, the basic domain of Stra13 contains a proline residue at an unprecedented position.	Proline	46-53	basic helix-loop-helix family member e40	Homo sapiens	28-34
11432722-0	2001	Induction of basic helix-loop-helix protein DEC1 (BHLHB2)/Stra13/Sharp2 in response to the cyclic adenosine monophosphate pathway.	Cyclic AMP	91-121	basic helix-loop-helix family member e40	Homo sapiens	50-56
11432722-0	2001	Induction of basic helix-loop-helix protein DEC1 (BHLHB2)/Stra13/Sharp2 in response to the cyclic adenosine monophosphate pathway.	Cyclic AMP	91-121	basic helix-loop-helix family member e40	Homo sapiens	58-64
11432722-0	2001	Induction of basic helix-loop-helix protein DEC1 (BHLHB2)/Stra13/Sharp2 in response to the cyclic adenosine monophosphate pathway.	Cyclic AMP	91-121	basic helix-loop-helix family member e40	Homo sapiens	65-71
11226878-1	2001	DEC1/BHLHB2 is a novel cAMP-inducible basic helix-loop-helix (bHLH) transcriptional factor isolated from human chondrocyte cultures by the subtraction method [Shen et al.	Cyclic AMP	23-27	basic helix-loop-helix family member e40	Homo sapiens	5-11
34917665-0	2021	17beta-Estradiol Inhibits Proliferation and Oxidative Stress in Vascular Smooth Muscle Cells by Upregulating BHLHE40 Expression.	Estradiol	0-16	basic helix-loop-helix family member e40	Homo sapiens	109-116
34917665-9	2021	Results: 17beta-Estradiol suppressed carotid artery ligation-induced intimal hyperplasia, which is accompanied by an increase of BHLHE40 level.	Estradiol	9-25	basic helix-loop-helix family member e40	Homo sapiens	129-136
34917665-11	2021	17beta-Estradiol inhibited TNF-alpha-induced VSMC proliferation and oxidative stress by promoting BHLHE40 expression, thereby suppressing MAPK signaling pathways.	Estradiol	0-16	basic helix-loop-helix family member e40	Homo sapiens	98-105
34917665-13	2021	Conclusions: Our study demonstrates that 17beta-Estradiol inhibits proliferation and oxidative stress in vivo and in vitro by promotion of BHLHE40 expression.	Estradiol	41-57	basic helix-loop-helix family member e40	Homo sapiens	139-146
34551158-9	2021	More importantly, forced overexpression of oxygen stable form of HIF1alpha completely reversed attenuated pro-inflammatory and glycolytic gene expression in BHLHE40-deficient macrophages.	Oxygen	43-49	basic helix-loop-helix family member e40	Homo sapiens	157-164