PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
25858458-6	2015	In the present study, by combining fate analysis of pulse-labeled cells and a model of vitamin A deficiency, we demonstrate that retinoic acid (RA), which may periodically increase in concentration in the tubules during the seminiferous epithelial cycle, induced only NGN3(+) cells to differentiate.	Tretinoin	129-142	neurogenin 3	Mus musculus	268-272
25762295-1	2016	Pluripotent stem cells are considered as a cell source for replacement therapies for pancreatic beta cells and other organs.We identified tetrabenazine (TBZ), vesicular monoamine transporter 2 (VMAT2) inhibitor as a promoter of late-stage differentiation of Pdx1-positive pancreatic progenitor cells into Ngn3-positive endocrine progenitor cells.	Tetrabenazine	138-151	neurogenin 3	Mus musculus	305-309
25762295-1	2016	Pluripotent stem cells are considered as a cell source for replacement therapies for pancreatic beta cells and other organs.We identified tetrabenazine (TBZ), vesicular monoamine transporter 2 (VMAT2) inhibitor as a promoter of late-stage differentiation of Pdx1-positive pancreatic progenitor cells into Ngn3-positive endocrine progenitor cells.	Tetrabenazine	153-156	neurogenin 3	Mus musculus	305-309
25858458-6	2015	In the present study, by combining fate analysis of pulse-labeled cells and a model of vitamin A deficiency, we demonstrate that retinoic acid (RA), which may periodically increase in concentration in the tubules during the seminiferous epithelial cycle, induced only NGN3(+) cells to differentiate.	Tretinoin	144-146	neurogenin 3	Mus musculus	268-272
24635696-3	2014	While we confirm that systemic delivery of adenovirus (Ad)-Ngn3 provides long-lasting correction of streptozotocin (STZ)-induced hyperglycemia and restoration of growth curves, we found that insulin levels and glucose tolerance tests are not fully restored.	Streptozocin	100-114	neurogenin 3	Mus musculus	59-63
24635696-3	2014	While we confirm that systemic delivery of adenovirus (Ad)-Ngn3 provides long-lasting correction of streptozotocin (STZ)-induced hyperglycemia and restoration of growth curves, we found that insulin levels and glucose tolerance tests are not fully restored.	Streptozocin	116-119	neurogenin 3	Mus musculus	59-63
24316738-3	2014	The present study identified reserpine and tetrabenazine (TBZ), both vesicular monoamine transporter 2 (VMAT2) inhibitors, as promoters of late-stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3 (referred to henceforth as Ngn3)-positive endocrine precursors.	Tetrabenazine	43-56	neurogenin 3	Mus musculus	216-223
24316738-3	2014	The present study identified reserpine and tetrabenazine (TBZ), both vesicular monoamine transporter 2 (VMAT2) inhibitors, as promoters of late-stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3 (referred to henceforth as Ngn3)-positive endocrine precursors.	Reserpine	29-38	neurogenin 3	Mus musculus	216-223
24316738-3	2014	The present study identified reserpine and tetrabenazine (TBZ), both vesicular monoamine transporter 2 (VMAT2) inhibitors, as promoters of late-stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3 (referred to henceforth as Ngn3)-positive endocrine precursors.	Reserpine	29-38	neurogenin 3	Mus musculus	251-255
24316738-3	2014	The present study identified reserpine and tetrabenazine (TBZ), both vesicular monoamine transporter 2 (VMAT2) inhibitors, as promoters of late-stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3 (referred to henceforth as Ngn3)-positive endocrine precursors.	Tetrabenazine	43-56	neurogenin 3	Mus musculus	251-255
24316738-3	2014	The present study identified reserpine and tetrabenazine (TBZ), both vesicular monoamine transporter 2 (VMAT2) inhibitors, as promoters of late-stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3 (referred to henceforth as Ngn3)-positive endocrine precursors.	Tetrabenazine	58-61	neurogenin 3	Mus musculus	216-223
24316738-3	2014	The present study identified reserpine and tetrabenazine (TBZ), both vesicular monoamine transporter 2 (VMAT2) inhibitors, as promoters of late-stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3 (referred to henceforth as Ngn3)-positive endocrine precursors.	Tetrabenazine	58-61	neurogenin 3	Mus musculus	251-255
23545157-1	2013	Estradiol promotes neuritogenesis in developing hippocampal neurons by a mechanism involving the upregulation of neurogenin 3, a Notch-regulated transcription factor.	Estradiol	0-9	neurogenin 3	Mus musculus	113-125
23545157-3	2013	GPER agonists (17beta-estradiol, G1, ICI 182,780) increased neurogenin 3 expression and neuritogenesis in mouse primary hippocampal neurons and this effect was blocked by the GPER antagonist G15 and by a siRNA for GPER.	Estradiol	15-31	neurogenin 3	Mus musculus	60-72
23545157-6	2013	Furthermore, the PI3K inhibitor wortmannin prevented the effect of G1 and estradiol on neurogenin 3 expression and the effect of estradiol on neuritogenesis.	Wortmannin	32-42	neurogenin 3	Mus musculus	87-99
23545157-6	2013	Furthermore, the PI3K inhibitor wortmannin prevented the effect of G1 and estradiol on neurogenin 3 expression and the effect of estradiol on neuritogenesis.	Estradiol	74-83	neurogenin 3	Mus musculus	87-99
23595988-4	2013	Treatment with l-3,5,3-triiodothyronine increases the association of TRalpha with the p85alpha subunit of phosphatidylinositol 3-kinase (PI3K), leading to the phosphorylation and activation of Akt and the expression of Pdx1, Ngn3, and MafA in purified acinar cells.	Triiodothyronine	15-39	neurogenin 3	Mus musculus	225-229
23595988-7	2013	The inhibition of p85alpha expression by siRNA or the inhibition of PI3K by LY294002 prevents the expression of Pdx1, Ngn3, and MafA and the reprogramming to insulin-producing cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	76-84	neurogenin 3	Mus musculus	118-122
23573363-5	2013	A combination of two PTF genes (Pdx1/Ngn3) effectively reprogrammed liver cells into glucose-responsive IPCs.	Glucose	85-92	neurogenin 3	Mus musculus	37-41
22776709-6	2013	For the first time, we have demonstrated that the coexpression of Pdx1 and MafA during a specific time window of development can act synergistically with either Ngn3 or NeuroD to promote the differentiation of mES cells into insulin-secreting cells.	2-(N-morpholino)ethanesulfonic acid	210-213	neurogenin 3	Mus musculus	161-165
21294959-0	2011	Pdx1- and Ngn3-Cre-mediated PLAG1 expression in the pancreas leads to endocrine hormone imbalances that affect glucose metabolism.	Glucose	111-118	neurogenin 3	Mus musculus	10-14
23383123-5	2013	Mutation of a leucine residue to alanine (L135A) in the NES2 motif resulted in both cytoplasmic and nuclear localization of the EGFP-NES2 fusion protein and in the nuclear accumulation of ectopic full-length myc-Ngn3.	Leucine	14-21	neurogenin 3	Mus musculus	212-216
23383123-5	2013	Mutation of a leucine residue to alanine (L135A) in the NES2 motif resulted in both cytoplasmic and nuclear localization of the EGFP-NES2 fusion protein and in the nuclear accumulation of ectopic full-length myc-Ngn3.	Alanine	33-40	neurogenin 3	Mus musculus	212-216
22426121-7	2012	Third, the effect of hypoxia was mediated by HIF1alpha, since the addition of an HIF1alpha inhibitor at 3% O(2) increased the number of NGN3-expressing progenitors as compared to nontreated controls (9.2-fold, P<0.001).	Oxygen	107-111	neurogenin 3	Mus musculus	136-140
22406641-2	2012	Here, we show that, unexpectedly, somatic ablation of Foxo1 in Neurog3(+) enteroendocrine progenitor cells gives rise to gut insulin-positive (Ins(+)) cells that express markers of mature beta cells and secrete bioactive insulin as well as C-peptide in response to glucose and sulfonylureas.	Glucose	265-272	neurogenin 3	Mus musculus	63-70
22406641-2	2012	Here, we show that, unexpectedly, somatic ablation of Foxo1 in Neurog3(+) enteroendocrine progenitor cells gives rise to gut insulin-positive (Ins(+)) cells that express markers of mature beta cells and secrete bioactive insulin as well as C-peptide in response to glucose and sulfonylureas.	Sulfonylurea Compounds	277-290	neurogenin 3	Mus musculus	63-70
20575431-6	2010	We got recombinant retrovirus vector pMSCV-ngn3, which was identified by double restriction enzyme digestion and then transfected into PT67 cells by lipofectamine 2000.	Lipofectamine	149-167	neurogenin 3	Mus musculus	43-47
20235092-9	2010	Treatment with leptomycin B, a potent and specific inhibitor of the exportin CRM1, induced its accumulation into the nucleus, suggesting that CRM1 mediates the nuclear export of Ngn3.	leptomycin B	15-27	neurogenin 3	Mus musculus	178-182
19446949-7	2009	Applying this knowledge to cell lines in which Pdx1 or Ngn3 transgene expression could be induced by exposure to doxycycline we differentiated TetPDX1 and TetNgn3 ESCs under conditions of either 10% FCS or 1% SR medium.	Doxycycline	113-124	neurogenin 3	Mus musculus	55-59
21099270-4	2009	During islet regeneration after injury of the adult mouse pancreas, such as by duct ligation or streptozotocin, Ngn3 is activated in duct-associated stem/progenitor cells that transform into alpha and/or beta cells (Xu et al, Collombat et al).	Streptozocin	96-110	neurogenin 3	Mus musculus	112-116
19819973-10	2009	Interestingly, the phenotype of NGN3-DPP2 kd mice is opposite that of DPP4 knockout mice with regard to glucose metabolism, namely the former have normal glucagon-like peptide 1 levels but present with glucose intolerance, whereas the latter have increased glucagon-like peptide 1, which is accompanied by augmented glucose tolerance.	Glucose	104-111	neurogenin 3	Mus musculus	32-36
19729673-0	2009	Embryonic stem cell transplantation correlates with endogenous neurogenin 3 expression and pancreas regeneration in streptozotocin-injured mice.	Streptozocin	116-130	neurogenin 3	Mus musculus	63-75
19819964-4	2009	We hence hypothesized that this gene therapy regimen may lead to a complete correction of the glucose and lipid metabolic abnormalities associated with insulin deficiency; we further hypothesized that the neo-islets formed in response to Ngn3-Btc gene delivery may display an ultrastructure and transcription profile similar to that of pancreatic islets.	Glucose	94-101	neurogenin 3	Mus musculus	238-242
19819964-5	2009	We injected streptozotocin-diabetic mice with helper-dependent adenoviral vectors carrying Ngn3 and Btc, which restored GSIS and reversed hyperglycemia in these animals.	Streptozocin	12-26	neurogenin 3	Mus musculus	91-95
19819964-10	2009	Taken together, this indicates that Ngn3-Btc gene therapy corrects the underlying dysregulated glucose and lipid metabolism in insulin-deficient diabetic mice by inducing neo-islets in the liver that are similar to pancreatic islets in structure and gene expression profile.	Glucose	95-102	neurogenin 3	Mus musculus	36-40
17922104-7	2007	Inhibiting Notch signalling with N-[N-(3,5-difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester (DAPT) increased Ngn3 mRNA expression and protein levels in adult islets.	n-[n-(3,5-difluorophenacetyl-l-alanyl)]-s-phenylglycine t-butyl ester	33-102	neurogenin 3	Mus musculus	120-124
17922104-7	2007	Inhibiting Notch signalling with N-[N-(3,5-difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester (DAPT) increased Ngn3 mRNA expression and protein levels in adult islets.	dapt	104-108	neurogenin 3	Mus musculus	120-124
16809427-3	2006	An mESC line was created in order to induce Ngn3 by adding doxycycline to the culture medium.	Doxycycline	59-70	neurogenin 3	Mus musculus	44-48
17336910-2	2007	To understand whether the competence of pancreatic progenitors changes over time, we generated transgenic mice expressing a tamoxifen-inducible Ngn3 fusion protein under the control of the pdx1 promoter and backcrossed the transgene into the ngn3(-/-) background, devoid of endogenous endocrine cells.	Tamoxifen	124-133	neurogenin 3	Mus musculus	144-148
17336910-2	2007	To understand whether the competence of pancreatic progenitors changes over time, we generated transgenic mice expressing a tamoxifen-inducible Ngn3 fusion protein under the control of the pdx1 promoter and backcrossed the transgene into the ngn3(-/-) background, devoid of endogenous endocrine cells.	Tamoxifen	124-133	neurogenin 3	Mus musculus	242-246
16809427-9	2006	Moreover, we find that Ngn3 induction in differentiating ESCs results in significant increases in insulin, glucagon, and somatostatin expression.	Glucagon	107-115	neurogenin 3	Mus musculus	23-27
15652518-0	2005	Enhanced expression of PDX-1 and Ngn3 by exendin-4 during beta cell regeneration in STZ-treated mice.	Streptozocin	84-87	neurogenin 3	Mus musculus	33-37
32467243-4	2020	In this study, we demonstrate that the disruption of RA signaling within the NEUROG3-expressing endocrine progenitor population impairs mouse beta cell differentiation and induces ectopic expression of crucial delta cell genes, including somatostatin.	Tretinoin	53-55	neurogenin 3	Mus musculus	77-84
34902439-8	2022	Also, we observed that DEX-treatment, in an HNF4alpha-dependent way, promoted an increase in PDX1, PAX4 and NGN3 gene expression.	Dextromethorphan	23-26	neurogenin 3	Mus musculus	108-112
35143826-12	2022	We have seen increased BrdU/Insulin and PDX1/Ngn3/Insulin co-positive cells in CR + GABA treated group with a reduction in apoptotic marker (TUNEL/Insulin co-positive cells).	gamma-Aminobutyric Acid	84-88	neurogenin 3	Mus musculus	45-49
32467243-5	2020	In addition, the inhibition of the RA pathway in hESC-derived pancreatic progenitors downstream of NEUROG3 induction impairs insulin expression.	Tretinoin	35-37	neurogenin 3	Mus musculus	99-106
32427857-2	2020	Moreover, the effect of 17-beta-estradiol (E2) on axonal growth and Ngn3 expression is only found in male-derived neurons.	Estradiol	24-41	neurogenin 3	Mus musculus	68-72
32427857-3	2020	To investigate whether sex chromosomes regulate these early sex differences in neuritogenesis by regulating the E2 effect on Ngn3, we evaluated the growth and differentiation of hypothalamic neurons derived from the "four core genotypes" mouse model, in which the factors of "gonadal sex" and "sex chromosome complement" are dissociated.	Estradiol	112-114	neurogenin 3	Mus musculus	125-129
32427857-5	2020	Moreover, E2 increased the mRNA expression of Ngn3 and axonal length only in XY neurons.	Estradiol	10-12	neurogenin 3	Mus musculus	46-50
32427857-7	2020	Together our data indicate that sex chromosomes regulate early development of hypothalamic neurons by orchestrating not only sex differences in neuritogenesis, but also regulating the effect of E2 on Ngn3 expression through activation of ERalpha in hypothalamic neurons.	Estradiol	194-196	neurogenin 3	Mus musculus	200-204
26337491-7	2017	After stimulation with picolinic acid and hypoxia, DPC expressed the endocrine differentiation marker Ngn3.	picolinic acid	23-37	neurogenin 3	Mus musculus	102-106
32361558-11	2020	Markers of new beta-cell formation (insulin, PDX1 and Ngn3) were observed in pancreatic ducts of HFD mice treated by puerarin.	puerarin	117-125	neurogenin 3	Mus musculus	54-58
31345937-2	2019	We generated Ngn3RapKO mice (ablation of Raptor, an essential component of mechanistic target of rapamycin [mTORC1] in Ngn3+ endocrine progenitor cells) and found that mTORC1 was dispensable for endocrine cell lineage formation but specifically regulated both proliferation and identity maintenance of neonatal beta-cells.	Sirolimus	97-106	neurogenin 3	Mus musculus	13-17
31015847-14	2019	The HRD showed dose-dependent effects on glucose metabolism improvement through maintenance of beta cell identity via a mechanism that might involve the Notch1/Ngn3 signal pathway in db/db mice.	Glucose	41-48	neurogenin 3	Mus musculus	160-164
28966671-6	2017	Furthermore, notable changes in the levels of Notch-1, pancreatic and duodenal homeobox 1 (PDX-1) and neurogenin 3 (Ngn3) were observed in the GBS group, indicating a potential role of Notch signaling in pancreatic islet regeneration after surgery.	gbs	143-146	neurogenin 3	Mus musculus	102-114
28966671-6	2017	Furthermore, notable changes in the levels of Notch-1, pancreatic and duodenal homeobox 1 (PDX-1) and neurogenin 3 (Ngn3) were observed in the GBS group, indicating a potential role of Notch signaling in pancreatic islet regeneration after surgery.	gbs	143-146	neurogenin 3	Mus musculus	116-120
28966671-7	2017	In addition, results obtained in PDX-1 knockout (KO), Notch-1 KO and Ngn3 KO mouse models with GBS suggested that elevated PDX-1 resulted in the inhibition of Notch-1, further facilitated Ngn3 and thus promoted pancreatic beta-cell regeneration after GBS.	gbs	95-98	neurogenin 3	Mus musculus	69-73
28966671-7	2017	In addition, results obtained in PDX-1 knockout (KO), Notch-1 KO and Ngn3 KO mouse models with GBS suggested that elevated PDX-1 resulted in the inhibition of Notch-1, further facilitated Ngn3 and thus promoted pancreatic beta-cell regeneration after GBS.	gbs	95-98	neurogenin 3	Mus musculus	188-192
28966671-7	2017	In addition, results obtained in PDX-1 knockout (KO), Notch-1 KO and Ngn3 KO mouse models with GBS suggested that elevated PDX-1 resulted in the inhibition of Notch-1, further facilitated Ngn3 and thus promoted pancreatic beta-cell regeneration after GBS.	gbs	251-254	neurogenin 3	Mus musculus	69-73
28966671-7	2017	In addition, results obtained in PDX-1 knockout (KO), Notch-1 KO and Ngn3 KO mouse models with GBS suggested that elevated PDX-1 resulted in the inhibition of Notch-1, further facilitated Ngn3 and thus promoted pancreatic beta-cell regeneration after GBS.	gbs	251-254	neurogenin 3	Mus musculus	188-192
28966671-8	2017	The present findings demonstrated that GBS in db/db mice resulted in pancreatic islet regeneration through the PDX-1/Notch-1/Ngn3 signaling pathway, which also reflected the important role of the gastrointestinal system in metabolism control.	gbs	39-42	neurogenin 3	Mus musculus	125-129
29250763-10	2018	Ngn3 and LIN28 expression were reduced after busulfan treatment compared to untreatmented mice.	Busulfan	45-53	neurogenin 3	Mus musculus	0-4
29078716-7	2017	However, exogenous testosterone increases neurogenin 3 expression and neuritogenesis in male XY neurons.	Testosterone	19-31	neurogenin 3	Mus musculus	42-54
27754935-6	2017	Neurogenin3-Tsc1-/- mice fed standard chow demonstrated a significant improvement in glucose tolerance and no alteration in insulin sensitivity.	Glucose	85-92	neurogenin 3	Mus musculus	0-11
27851966-1	2016	Using a transgenic mouse model to express MafA, Pdx1, and Neurog3 (3TF) in a pancreatic acinar cell- and doxycycline-dependent manner, we discovered that the outcome of transcription factor-mediated acinar to beta-like cellular reprogramming is dependent on both the magnitude of 3TF expression and on reprogramming-induced inflammation.	Doxycycline	105-116	neurogenin 3	Mus musculus	58-65
27076404-5	2016	Treatment with PDGF-AA was found to facilitate Pdx1 and Ngn3-induced reprogramming of hepatocytes to beta-like cells with the ability to secrete insulin in response to glucose stimulus.	Glucose	168-175	neurogenin 3	Mus musculus	56-60
27583450-6	2016	Committed progenitor cells expressing Ngn3 normally do not contribute to SSCs marked by the Id4-Gfp transgene, but do so when spermatogonia are chemically depleted using busulfan.	Busulfan	170-178	neurogenin 3	Mus musculus	38-42
27583450-7	2016	Removal of Dmrt1 from Ngn3-positive germ cells blocks the replenishment of Id4-GFP-positive SSCs and recovery of spermatogenesis after busulfan treatment.	Busulfan	135-143	neurogenin 3	Mus musculus	22-26