PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
30624066-8	2019	The Ka measured by proxy ligand-ESI-MS for AGP, Hp1-1 and alpha2M (4 x 105 M-1, 2 x 105 M-1 and 3 x 105 M-1, respectively) are consistent with the reported apparent affinities of hGal-3 for serum GPs and their N-glycans.	n-glycans	210-219	defensin alpha 1	Homo sapiens	48-53
31830177-1	2020	A new hybrid lead iodide material (HP1) having 4-vinylphenylene ammonium as the organic cation has been prepared.	Iodides	18-24	defensin alpha 1	Homo sapiens	35-38
31830177-1	2020	A new hybrid lead iodide material (HP1) having 4-vinylphenylene ammonium as the organic cation has been prepared.	Ammonium Compounds	47-72	defensin alpha 1	Homo sapiens	35-38
31830177-2	2020	The structural formula based on chemical analysis of HP1 corresponds to PbI2.5(4-styrylammonium)0.5.	BE 4-4-4-4	79-95	defensin alpha 1	Homo sapiens	53-56
31830177-4	2020	The presence of the styryl ammonium moiety in HP1 allows post-synthetic modification by radical copolymerization with styrene to obtain the HP2 material with higher hydrophobicity.	Ammonium Compounds	20-35	defensin alpha 1	Homo sapiens	46-49
31830177-4	2020	The presence of the styryl ammonium moiety in HP1 allows post-synthetic modification by radical copolymerization with styrene to obtain the HP2 material with higher hydrophobicity.	Styrene	118-125	defensin alpha 1	Homo sapiens	46-49
31830177-5	2020	Stability tests reveal that both HP1 and HP2 show hydrogen evolution in the dark, indicating about 0.6% partial decomposition of the hybrid material.	Hydrogen	50-58	defensin alpha 1	Homo sapiens	33-36
31830177-6	2020	This hydrogen evolution increases by a factor of 3 when HP1 and HP2 are exposed to visible light.	Hydrogen	5-13	defensin alpha 1	Homo sapiens	56-59
31116063-8	2020	Furthermore, platelets secreted DEFA1 into the culture medium when activated with thrombin, adenosine diphosphate, and lipopolysaccharide; meanwhile, MEG-01 cells secreted DEFA1 when activated with thrombopoietin.	Adenosine Diphosphate	92-113	defensin alpha 1	Homo sapiens	32-37
30771006-3	2019	UDG can recognize and hydrolyze the uracil bases from the stem of hairpin DNA1 (HP1).	Uracil	36-42	defensin alpha 1	Homo sapiens	80-83
31117410-2	2019	In this strategy, a Kana-recognition region, primer-like palindromic fragment, and polymerization/nicking template are reasonably integrated into one oligonucleotide (hairpin HP1) for target recognition, magnetic separation, and target amplification.	Oligonucleotides	150-165	defensin alpha 1	Homo sapiens	175-178
30625609-2	2019	In this study, a new strategy was designed for simple, sensitive, and selective platform to detect the mRNA levels by combining a hairpin probe-graphene oxide (HP1/GO) and duplex-specific nuclease signal amplification (DSNSA).	graphene oxide	144-158	defensin alpha 1	Homo sapiens	160-166
25656535-6	2015	RESULTS: According to quantification using Progenesis LC-MS software, only the protein neutrophil defensin 1, which was reported to participate in reducing blood glucose levels, was increased in the urine after glucose intake; and almost all urinary proteins may not be affected.	Glucose	211-218	defensin alpha 1	Homo sapiens	87-108
27002905-9	2016	Our results showed that fat deposition-related parameters including fat content in bone marrow and water content in the lumbar vertebra are clearly different between the osteoporosis and non-osteoporosis group, suggesting that both 1H-MRS and in-phase and out-of-phase MRI can be used for diagnosing osteoporosis and monitoring its progression.	Water	99-104	defensin alpha 1	Homo sapiens	232-238
25656535-6	2015	RESULTS: According to quantification using Progenesis LC-MS software, only the protein neutrophil defensin 1, which was reported to participate in reducing blood glucose levels, was increased in the urine after glucose intake; and almost all urinary proteins may not be affected.	Glucose	162-169	defensin alpha 1	Homo sapiens	87-108
24643009-6	2014	The gating mechanism in the inward-facing state of EAAT3 is found to be different from that of GltPh, which is traced to the relocation of an arginine residue from the HP1 segment in GltPh to the TM8 segment in EAAT3.	Arginine	142-150	defensin alpha 1	Homo sapiens	168-171
24927542-4	2014	Here, we demonstrate that a complex containing kap-1, HP1, and the H3K9 methyltransferase suv39h1 is rapidly loaded onto the chromatin at DSBs.	1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione	138-142	defensin alpha 1	Homo sapiens	54-57
24927542-11	2014	Recruitment of kap-1/HP1/suv39h1 to DSBs therefore provides a mechanism for transiently increasing the levels of H3K9me3 in open chromatin domains that lack H3K9me3 and thereby promoting efficient activation of Tip60 and ATM in these regions.	1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione	36-40	defensin alpha 1	Homo sapiens	21-24
22369205-12	2012	The maximal dose enhancement was seen in U251 cells treated with 75 nmol/L vosaroxin (DEF 1.51).	vosaroxin	75-84	defensin alpha 1	Homo sapiens	86-91
23142570-2	2013	All samples had anti-T. vaginalis activity; however, HP1 demonstrated the best selectivity against this protozoan (metronidazole-resistant and susceptible isolates), with no cytotoxicity on mammalian cells (selectivity index of 73.97).	Metronidazole	115-128	defensin alpha 1	Homo sapiens	53-56
23142570-3	2013	Moreover, HP1 had activity against a metronidazole-resistant isolate (52% of viable trophozoites), and this effect was higher when tested with a low concentration of metronidazole (23% of viable trophozoites).	Metronidazole	37-50	defensin alpha 1	Homo sapiens	10-13
23142570-3	2013	Moreover, HP1 had activity against a metronidazole-resistant isolate (52% of viable trophozoites), and this effect was higher when tested with a low concentration of metronidazole (23% of viable trophozoites).	Metronidazole	166-179	defensin alpha 1	Homo sapiens	10-13
23142570-5	2013	Therefore, the analyzed molecules are promising prototypes for new antiprotozoal drugs, especially HP1, which seems to improve metronidazole"s effect on a resistant T. vaginalis isolate.	Metronidazole	127-140	defensin alpha 1	Homo sapiens	99-102
23050799-6	2012	Additionally, the proteins encoded by DEFA 1/3 and DEFA 4 were visualized in paraffin-embedded tissue sections by immunohistochemical staining.	Paraffin	77-85	defensin alpha 1	Homo sapiens	38-46
22621770-9	2012	Furthermore, higher expression of KLF9, SNAI1 and DEFA1 was found in ZZ COPD lungs without augmentation therapy relative to MM COPD or ZZ COPD with augmentation therapy.	zz	69-71	defensin alpha 1	Homo sapiens	50-55
20085281-2	2010	Four hydroxypropylated psyllium derivatives, denoted as HP1, HP2, HP3, and HP4, were characterized for their hydroxypropyl content, molar substitution, and IR spectra.	Hypromellose Derivatives	5-18	defensin alpha 1	Homo sapiens	56-59
22848211-2	2012	As polysaccharides exhibit structure-dependent biological functions in the present study water-soluble polysaccharides were extracted from herb material, fractionated by anion exchange chromatography into four main polysaccharide fractions (denominated as Hp1, Hp2, Hp3 and Hp4) and characterized by HPAEC-PAD, CE, IR and GC-MS.	Polysaccharides	3-18	defensin alpha 1	Homo sapiens	256-259
22848211-5	2012	Polysaccharide fraction Hp1 was mainly composed of beta-D-glucose.	Polysaccharides	0-14	defensin alpha 1	Homo sapiens	24-27
22848211-5	2012	Polysaccharide fraction Hp1 was mainly composed of beta-D-glucose.	Zymosan	51-65	defensin alpha 1	Homo sapiens	24-27
22848211-7	2012	Polysaccharides of Hp1 induced the keratinocyte differentiation by inhibiting the gene expression of the epidermal growth factor and insulin receptor.	Polysaccharides	0-15	defensin alpha 1	Homo sapiens	19-22
21707032-3	2011	The main identified compounds were rutin (HP3 and HP4) and caffeic and chlorogenic (5-caffeoyl quinic) acids (HP1, HP3, and HP4).	5-caffeoyl quinic) acids	84-108	defensin alpha 1	Homo sapiens	110-113
20085281-2	2010	Four hydroxypropylated psyllium derivatives, denoted as HP1, HP2, HP3, and HP4, were characterized for their hydroxypropyl content, molar substitution, and IR spectra.	hydroxypropylated psyllium	5-31	defensin alpha 1	Homo sapiens	56-59
17303777-5	2007	Subjects in the highest quartile for plasma DEFA1-3 were found to be leaner and more insulin sensitive, and to have significantly reduced total and LDL-cholesterol, compared with subjects in the lowest quartile for circulating DEFA1-3 (P<0.0001 to P=0.002 for linear trend ANOVA).	Cholesterol	152-163	defensin alpha 1	Homo sapiens	44-49
17403666-5	2007	Point mutations of Lys-9 and Lys-27 to block cellular modifications of the tail domains completely abolished the association of specific factors, including HP1 and several repressors.	Lysine	19-22	defensin alpha 1	Homo sapiens	156-159
17403666-5	2007	Point mutations of Lys-9 and Lys-27 to block cellular modifications of the tail domains completely abolished the association of specific factors, including HP1 and several repressors.	Lysine	29-32	defensin alpha 1	Homo sapiens	156-159
17303777-5	2007	Subjects in the highest quartile for plasma DEFA1-3 were found to be leaner and more insulin sensitive, and to have significantly reduced total and LDL-cholesterol, compared with subjects in the lowest quartile for circulating DEFA1-3 (P<0.0001 to P=0.002 for linear trend ANOVA).	Cholesterol	152-163	defensin alpha 1	Homo sapiens	44-51
17303777-8	2007	CONCLUSIONS: Circulating DEFA1-3 are associated with serum cholesterol and vascular reactivity in humans.	Cholesterol	59-70	defensin alpha 1	Homo sapiens	25-30
16801413-5	2006	A 1-h treatment of Klebsiella pneumoniae with 0.25 x the MIC of ciprofloxacin rendered bacteria more sensitive to polymyxins B and E, human neutrophil defensin 1, and beta-defensin 1.	Ciprofloxacin	64-77	defensin alpha 1	Homo sapiens	140-161
16732293-2	2006	Tri- and dimethylation of lysine 9 on histone H3 (H3K9me3/me2) is required for the binding of the repressive protein HP1 and is associated with heterochromatin formation and transcriptional repression in a variety of species.	Lysine	26-32	defensin alpha 1	Homo sapiens	117-120
15120635-5	2004	By immunoprecipitation and GST pull-down, we show that DNMT3B interacts with HDAC1, HDAC2, HP1 proteins, Suv39h1, and the ATP-dependent chromatin remodeling enzyme hSNF2H.	Adenosine Triphosphate	122-125	defensin alpha 1	Homo sapiens	91-94
16709851-9	2006	As GABP is widely expressed, a strong TATA box thus alleviates promyelocytic cell specificity of the def1 promoter.	gabp	3-7	defensin alpha 1	Homo sapiens	101-105
16213461-2	2005	HP1 so targeted can reconstitute tri-methylated lysine 9 of histone H3 (Me(3)K9H3) and tri-methylated lysine 20 of histone H4 (Me(3)K20H4) at pericentric heterochromatin, indicating that HP1 can regulate the distribution of these histone modifications in vivo.	Lysine	48-54	defensin alpha 1	Homo sapiens	0-3
16213461-2	2005	HP1 so targeted can reconstitute tri-methylated lysine 9 of histone H3 (Me(3)K9H3) and tri-methylated lysine 20 of histone H4 (Me(3)K20H4) at pericentric heterochromatin, indicating that HP1 can regulate the distribution of these histone modifications in vivo.	Lysine	48-54	defensin alpha 1	Homo sapiens	187-190
16213461-2	2005	HP1 so targeted can reconstitute tri-methylated lysine 9 of histone H3 (Me(3)K9H3) and tri-methylated lysine 20 of histone H4 (Me(3)K20H4) at pericentric heterochromatin, indicating that HP1 can regulate the distribution of these histone modifications in vivo.	me(3)k9h3	72-81	defensin alpha 1	Homo sapiens	0-3
16213461-2	2005	HP1 so targeted can reconstitute tri-methylated lysine 9 of histone H3 (Me(3)K9H3) and tri-methylated lysine 20 of histone H4 (Me(3)K20H4) at pericentric heterochromatin, indicating that HP1 can regulate the distribution of these histone modifications in vivo.	me(3)k9h3	72-81	defensin alpha 1	Homo sapiens	187-190
16213461-2	2005	HP1 so targeted can reconstitute tri-methylated lysine 9 of histone H3 (Me(3)K9H3) and tri-methylated lysine 20 of histone H4 (Me(3)K20H4) at pericentric heterochromatin, indicating that HP1 can regulate the distribution of these histone modifications in vivo.	Lysine	102-108	defensin alpha 1	Homo sapiens	0-3
16213461-2	2005	HP1 so targeted can reconstitute tri-methylated lysine 9 of histone H3 (Me(3)K9H3) and tri-methylated lysine 20 of histone H4 (Me(3)K20H4) at pericentric heterochromatin, indicating that HP1 can regulate the distribution of these histone modifications in vivo.	Lysine	102-108	defensin alpha 1	Homo sapiens	187-190
16213461-2	2005	HP1 so targeted can reconstitute tri-methylated lysine 9 of histone H3 (Me(3)K9H3) and tri-methylated lysine 20 of histone H4 (Me(3)K20H4) at pericentric heterochromatin, indicating that HP1 can regulate the distribution of these histone modifications in vivo.	me(3)k20h4	127-137	defensin alpha 1	Homo sapiens	0-3
16213461-2	2005	HP1 so targeted can reconstitute tri-methylated lysine 9 of histone H3 (Me(3)K9H3) and tri-methylated lysine 20 of histone H4 (Me(3)K20H4) at pericentric heterochromatin, indicating that HP1 can regulate the distribution of these histone modifications in vivo.	me(3)k20h4	127-137	defensin alpha 1	Homo sapiens	187-190
16254244-7	2005	After TSA and NaBt treatment, the HP1 proteins were repositioned more internally in the nucleus, being closely associated with interchromatin compartments, while centromeric heterochromatin was relocated closer to the nuclear periphery.	trichostatin A	6-9	defensin alpha 1	Homo sapiens	34-37
16254244-7	2005	After TSA and NaBt treatment, the HP1 proteins were repositioned more internally in the nucleus, being closely associated with interchromatin compartments, while centromeric heterochromatin was relocated closer to the nuclear periphery.	NABT	14-18	defensin alpha 1	Homo sapiens	34-37
11959841-2	2002	Recent genetic and biochemical studies link H3-lysine 9 (H3-K9) methylation to HP1-mediated heterochromatin formation and gene silencing.	h3-lysine	44-53	defensin alpha 1	Homo sapiens	79-82
12498693-2	2002	Histone H3 lysine 9 (H3K9) methylation is an epigenetic signal that is recognized by HP1 and correlates with gene silencing in a variety of organisms.	Lysine	11-17	defensin alpha 1	Homo sapiens	85-88
12903463-6	2000	RESULTS: The TH/TP ratio of control and the gossypol treated group were 0.17 +/- 0.07 and 0.63 +/- 0.79(P < 0.05); The HP1/(HP2+HP3) ratio of control and gossypol treated group were 1.05 +/- 0.21 and 1.47 +/- 0.18 (P < 0.01).	Gossypol	44-52	defensin alpha 1	Homo sapiens	122-125
11565038-3	2001	Hp phenotyping performed by starch-gel electrophoresis produced a haptoglobin-hemoglobin complex of three phenotypes: Hp1-1, Hp2-2, and Hp2-1.	Starch	28-34	defensin alpha 1	Homo sapiens	118-123
11242053-0	2001	Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.	Lysine	26-32	defensin alpha 1	Homo sapiens	62-65
11242053-3	2001	Here we show that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins--a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.	HS 3	82-84	defensin alpha 1	Homo sapiens	142-145
11242053-3	2001	Here we show that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins--a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.	Lysine	88-94	defensin alpha 1	Homo sapiens	142-145
11242053-4	2001	High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromo domain; thus, the HP1 chromo domain is a specific interaction motif for the methyl epitope on lysine9 of histone H3.	lysine9	200-207	defensin alpha 1	Homo sapiens	73-76
11083633-4	2000	The candidacidal activity of human neutrophil defensin 1 (HNP-1) shared very similar features to Hst 5 cytotoxic action with respect to active concentrations and magnitude of induction of nonlytic ATP efflux, depletion of intracellular ATP pools, and inhibitor profile.	Adenosine Triphosphate	197-200	defensin alpha 1	Homo sapiens	35-56
11083633-4	2000	The candidacidal activity of human neutrophil defensin 1 (HNP-1) shared very similar features to Hst 5 cytotoxic action with respect to active concentrations and magnitude of induction of nonlytic ATP efflux, depletion of intracellular ATP pools, and inhibitor profile.	Adenosine Triphosphate	236-239	defensin alpha 1	Homo sapiens	35-56
11788710-2	2002	It specifically methylates K9 of histone H3, thereby creating a high affinity binding site for HP1 proteins.	k9	27-29	defensin alpha 1	Homo sapiens	95-98
11788710-4	2002	Strikingly, both HP1 localisation and repression by Rb also require, at least in part, histone deacetylases.	Rubidium	52-54	defensin alpha 1	Homo sapiens	17-20
11779497-1	2001	Methylation of histone H3 at lysine 9 by SUV39H1 and subsequent recruitment of the heterochromatin protein HP1 has recently been linked to gene silencing.	Lysine	29-35	defensin alpha 1	Homo sapiens	107-110
12903463-6	2000	RESULTS: The TH/TP ratio of control and the gossypol treated group were 0.17 +/- 0.07 and 0.63 +/- 0.79(P < 0.05); The HP1/(HP2+HP3) ratio of control and gossypol treated group were 1.05 +/- 0.21 and 1.47 +/- 0.18 (P < 0.01).	Gossypol	157-165	defensin alpha 1	Homo sapiens	122-125
33587625-3	2021	In the case of half of the hydrogen bonds, a phase transition from AP to the first high-pressure phase (HP1) at ~1.2 GPa resulted in an increase in the H-H distances, which suggested that the dihydrogen bonds were broken.	Hydrogen	27-35	defensin alpha 1	Homo sapiens	104-107
10369762-7	1999	Extrapolation of the tausvalues measured in standard buffer (50 mM Tris (pH 7.5) and 12 mM MgCl2) to zero RNA concentration provide values of 112, 93, and 73 ns for HP1, HP2 and HP3, respectively, at 30 degrees C, indicating increasingly compact structures.	Tromethamine	67-71	defensin alpha 1	Homo sapiens	165-168
10369762-7	1999	Extrapolation of the tausvalues measured in standard buffer (50 mM Tris (pH 7.5) and 12 mM MgCl2) to zero RNA concentration provide values of 112, 93, and 73 ns for HP1, HP2 and HP3, respectively, at 30 degrees C, indicating increasingly compact structures.	Magnesium Chloride	91-96	defensin alpha 1	Homo sapiens	165-168
8353023-5	1993	We evaluated whether two human CS-defensins, HP-1 and HP-4, are able to modulate in vitro spontaneous NK cell activity of human peripheral blood mononuclear (PBM) cells and in vitro susceptibility to the stimulatory effect by immune interferon (IFN-gamma) or interleukin 2 (IL-2) and to the inhibitory effect of cortisol.	Hydrocortisone	312-320	defensin alpha 1	Homo sapiens	31-58
10083861-9	1999	Replacing carboplatin by cisplatin in an identical set-up demonstrated exclusively simple additivity (DEF = 1).	Carboplatin	10-21	defensin alpha 1	Homo sapiens	102-109
10083861-9	1999	Replacing carboplatin by cisplatin in an identical set-up demonstrated exclusively simple additivity (DEF = 1).	Cisplatin	25-34	defensin alpha 1	Homo sapiens	102-109
7698078-3	1994	UGT-HP1 exhibited a limited substrate specificity for planar phenolic compounds, whereas UGT-HP4 was more accepting of nonplanar phenols, anthraquinones, flavones, alphatic alcohols, aromatic carboxylic acids, steroids and many drugs of varied structure.	Flavones	154-162	defensin alpha 1	Homo sapiens	4-7
7698078-3	1994	UGT-HP1 exhibited a limited substrate specificity for planar phenolic compounds, whereas UGT-HP4 was more accepting of nonplanar phenols, anthraquinones, flavones, alphatic alcohols, aromatic carboxylic acids, steroids and many drugs of varied structure.	alphatic alcohols	164-181	defensin alpha 1	Homo sapiens	4-7
7698078-3	1994	UGT-HP1 exhibited a limited substrate specificity for planar phenolic compounds, whereas UGT-HP4 was more accepting of nonplanar phenols, anthraquinones, flavones, alphatic alcohols, aromatic carboxylic acids, steroids and many drugs of varied structure.	Benzoic Acid	183-208	defensin alpha 1	Homo sapiens	4-7
7698078-3	1994	UGT-HP1 exhibited a limited substrate specificity for planar phenolic compounds, whereas UGT-HP4 was more accepting of nonplanar phenols, anthraquinones, flavones, alphatic alcohols, aromatic carboxylic acids, steroids and many drugs of varied structure.	Steroids	210-218	defensin alpha 1	Homo sapiens	4-7
8435089-2	1993	Phenol UGT HP1 was expressed at a similar, relatively low, abundance in each liver and kidney whereas phenol UGT HP4 was more highly expressed in the kidney.	Phenol	0-6	defensin alpha 1	Homo sapiens	11-14
35008019-4	2022	In this assay, HP1 and HP4 were immobilized on the surface of cage Au@AuNPs.	Gold	67-69	defensin alpha 1	Homo sapiens	15-18
34627513-3	2021	The developed system consists of four types of designed hairpin DNA HP1, HP2, H1, and fluorophore-labeled H2, which are absorbed on the GO nanosheets surface leading to fluorescence quenching.	graphene oxide	136-138	defensin alpha 1	Homo sapiens	68-71
34116751-6	2021	The recoveries of urea were 91.4 % and 109.9 % in DEF-1 and DEF-2, respectively.	Urea	18-22	defensin alpha 1	Homo sapiens	50-55