PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 32680850-4 2020 The homozygous dDBT mutant larvae recapitulate an array of MSUD phenotypes, including aberrant BCAA accumulation, developmental defects, poor mobile behavior, and disrupted L-glutamate homeostasis. Amino Acids, Branched-Chain 95-99 discs overgrown Drosophila melanogaster 15-19 32680850-4 2020 The homozygous dDBT mutant larvae recapitulate an array of MSUD phenotypes, including aberrant BCAA accumulation, developmental defects, poor mobile behavior, and disrupted L-glutamate homeostasis. Glutamic Acid 173-184 discs overgrown Drosophila melanogaster 15-19 32680850-9 2020 Importantly, when the dDBT mutants were administrated with Metformin, the aberrances in BCAA levels and motor behavior were ameliorated. Metformin 59-68 discs overgrown Drosophila melanogaster 22-26 32680850-9 2020 Importantly, when the dDBT mutants were administrated with Metformin, the aberrances in BCAA levels and motor behavior were ameliorated. Amino Acids, Branched-Chain 88-92 discs overgrown Drosophila melanogaster 22-26 24210908-3 2013 RNAi-mediated knockdown of CG17282 produced behavioral arrhythmicity and long periods and high levels of hypophosphorylated nuclear PERIOD and phosphorylated DOUBLETIME. cg17282 27-34 discs overgrown Drosophila melanogaster 158-168 34005114-4 2020 The homozygous dDBT mutant larvae recapitulate an array of MSUD phenotypes, including aberrant BCAA accumulation, developmental defects, poor mobile behavior, and disrupted L-glutamate homeostasis. Amino Acids, Branched-Chain 95-99 discs overgrown Drosophila melanogaster 15-19 34005114-4 2020 The homozygous dDBT mutant larvae recapitulate an array of MSUD phenotypes, including aberrant BCAA accumulation, developmental defects, poor mobile behavior, and disrupted L-glutamate homeostasis. Glutamic Acid 173-184 discs overgrown Drosophila melanogaster 15-19 34005114-9 2020 Importantly, when the dDBT mutants were administrated with Metformin, the aberrances in BCAA levels and motor behavior were ameliorated. Metformin 59-68 discs overgrown Drosophila melanogaster 22-26 34005114-9 2020 Importantly, when the dDBT mutants were administrated with Metformin, the aberrances in BCAA levels and motor behavior were ameliorated. Amino Acids, Branched-Chain 88-92 discs overgrown Drosophila melanogaster 22-26 24210908-5 2013 In photoreceptors, CG17282 accumulates rhythmically in PERIOD- and DOUBLETIME-dependent cytosolic foci. cg17282 19-26 discs overgrown Drosophila melanogaster 67-77 14701759-6 2004 Glutathione S-transferase pull-down assays and coimmunoprecipitation of DBT and PER showed that wild-type DBT, DBT(S), and DBT(L) proteins can bind to PER equivalently and that these interactions are mediated by the evolutionarily conserved N-terminal part of DBT. Glutathione 0-11 discs overgrown Drosophila melanogaster 106-109 21992330-7 2011 Analysis of the ORR free energy diagrams, built for the Pd and Pd/Pd(0.75)Co(0.25), shows that the co-adsorption of the ORR intermediates and water changes the ORR energetics significantly and makes ORR more favorable. Palladium 63-65 discs overgrown Drosophila melanogaster 99-101 21992330-7 2011 Analysis of the ORR free energy diagrams, built for the Pd and Pd/Pd(0.75)Co(0.25), shows that the co-adsorption of the ORR intermediates and water changes the ORR energetics significantly and makes ORR more favorable. Cobalt 74-76 discs overgrown Drosophila melanogaster 99-101 21992330-7 2011 Analysis of the ORR free energy diagrams, built for the Pd and Pd/Pd(0.75)Co(0.25), shows that the co-adsorption of the ORR intermediates and water changes the ORR energetics significantly and makes ORR more favorable. Water 142-147 discs overgrown Drosophila melanogaster 99-101 21992330-8 2011 We find the onset ORR potential estimated for the configurations with the O-OH and OH-OH co-adsorption to be in very good agreement with experiment. o-oh 74-78 discs overgrown Drosophila melanogaster 50-52 21992330-8 2011 We find the onset ORR potential estimated for the configurations with the O-OH and OH-OH co-adsorption to be in very good agreement with experiment. Hydrogen Peroxide 83-88 discs overgrown Drosophila melanogaster 50-52 18258753-2 2008 Genetic and biochemical studies have shown that dbt and its mammalian ortholog casein kinase I epsilon (hckI epsilon) regulate the circadian phosphorylation of period (per), thus controlling per subcellular localization and stability. dbt 48-51 discs overgrown Drosophila melanogaster 79-102 17322874-3 2007 AMI is restored when a DCO transgene is expressed in mushroom bodies, structures important for olfactory memory formation. amicoumacin A 0-3 discs overgrown Drosophila melanogaster 23-26 21992330-3 2011 We find the hybridization of dPd and dCo electronic states to be the main factor controlling the electrocatalytic properties of Pd/Pd(0.75)Co(0.25). Palladium 128-130 discs overgrown Drosophila melanogaster 37-40 21992330-4 2011 Namely the dPd-dCo hybridization causes low energy shift of the surface Pd d-band with respect to that for Pd(111). Palladium 12-14 discs overgrown Drosophila melanogaster 15-18 21992330-7 2011 Analysis of the ORR free energy diagrams, built for the Pd and Pd/Pd(0.75)Co(0.25), shows that the co-adsorption of the ORR intermediates and water changes the ORR energetics significantly and makes ORR more favorable. Palladium 56-58 discs overgrown Drosophila melanogaster 99-101 21992330-7 2011 Analysis of the ORR free energy diagrams, built for the Pd and Pd/Pd(0.75)Co(0.25), shows that the co-adsorption of the ORR intermediates and water changes the ORR energetics significantly and makes ORR more favorable. Palladium 63-65 discs overgrown Drosophila melanogaster 99-101 16543224-4 2006 This hyperphosphorylation occurs in parallel with the PER-dependent entry of DOUBLE-TIME (DBT) kinase into a complex with CLK-CYC, where DBT destabilizes both CLK and PER. dbt 90-93 discs overgrown Drosophila melanogaster 77-88 14701759-6 2004 Glutathione S-transferase pull-down assays and coimmunoprecipitation of DBT and PER showed that wild-type DBT, DBT(S), and DBT(L) proteins can bind to PER equivalently and that these interactions are mediated by the evolutionarily conserved N-terminal part of DBT. Glutathione 0-11 discs overgrown Drosophila melanogaster 106-109 14701759-6 2004 Glutathione S-transferase pull-down assays and coimmunoprecipitation of DBT and PER showed that wild-type DBT, DBT(S), and DBT(L) proteins can bind to PER equivalently and that these interactions are mediated by the evolutionarily conserved N-terminal part of DBT. Glutathione 0-11 discs overgrown Drosophila melanogaster 106-109 14701759-6 2004 Glutathione S-transferase pull-down assays and coimmunoprecipitation of DBT and PER showed that wild-type DBT, DBT(S), and DBT(L) proteins can bind to PER equivalently and that these interactions are mediated by the evolutionarily conserved N-terminal part of DBT. Glutathione 0-11 discs overgrown Drosophila melanogaster 106-109