PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
35533964-6	2022	What"s more, beta-carotene was found to reduce the index levels of oxidative stress response (HMOX-1, reactive oxygen species (ROS), NADPH, MDA), inflammatory factors (interleukine-1beta (IL-1beta), interleukine-6 (IL-6), interleukine-8 (IL-8), tumor necrosis factor-alpha (TNF-alpha)), liver function protein (AST, ALT) which increased by CuSO4.	beta Carotene	13-26	heme oxygenase 1a	Danio rerio	94-100
34544203-3	2022	Heme oxygenase 1 (HMOX1) is a critical regulator of iron homeostasis that catalyses the liberation of iron during degradation of heme.	Iron	52-56	heme oxygenase 1a	Danio rerio	0-16
34544203-3	2022	Heme oxygenase 1 (HMOX1) is a critical regulator of iron homeostasis that catalyses the liberation of iron during degradation of heme.	Iron	52-56	heme oxygenase 1a	Danio rerio	18-23
34544203-3	2022	Heme oxygenase 1 (HMOX1) is a critical regulator of iron homeostasis that catalyses the liberation of iron during degradation of heme.	Iron	102-106	heme oxygenase 1a	Danio rerio	0-16
34544203-3	2022	Heme oxygenase 1 (HMOX1) is a critical regulator of iron homeostasis that catalyses the liberation of iron during degradation of heme.	Iron	102-106	heme oxygenase 1a	Danio rerio	18-23
34544203-3	2022	Heme oxygenase 1 (HMOX1) is a critical regulator of iron homeostasis that catalyses the liberation of iron during degradation of heme.	Heme	129-133	heme oxygenase 1a	Danio rerio	0-16
34544203-3	2022	Heme oxygenase 1 (HMOX1) is a critical regulator of iron homeostasis that catalyses the liberation of iron during degradation of heme.	Heme	129-133	heme oxygenase 1a	Danio rerio	18-23
34544203-8	2022	Using genetic and chemical tools, we show zebrafish Hmox1a protects the host against M. marinum infection by reducing infection-induced iron accumulation and ferrostatin-sensitive cell death.	Iron	136-140	heme oxygenase 1a	Danio rerio	52-58
34544203-8	2022	Using genetic and chemical tools, we show zebrafish Hmox1a protects the host against M. marinum infection by reducing infection-induced iron accumulation and ferrostatin-sensitive cell death.	ferrostatin	158-169	heme oxygenase 1a	Danio rerio	52-58
20200220-11	2010	Furthermore, we showed that morpholino-mediated knockdown of Nrf2 reduced PFOS-induced HO-1 gene expression.	perfluorooctane sulfonic acid	74-78	heme oxygenase 1a	Danio rerio	87-91
18045703-0	2008	The role of cyp1a and heme oxygenase 1 gene expression for the toxicity of 3,4-dichloroaniline in zebrafish (Danio rerio) embryos.	3,4-dichloroaniline	75-94	heme oxygenase 1a	Danio rerio	22-38
18045703-5	2008	To evaluate the significance of two of the most sensitive genes, cytochrome P 450 1a (cyp1a) and heme oxygenase 1 (hmox1), for 3,4-DCA toxicity, RNA interference-mediated knockdown and overexpression studies have been conducted.	3,4-dichloroaniline	127-134	heme oxygenase 1a	Danio rerio	97-113
18045703-5	2008	To evaluate the significance of two of the most sensitive genes, cytochrome P 450 1a (cyp1a) and heme oxygenase 1 (hmox1), for 3,4-DCA toxicity, RNA interference-mediated knockdown and overexpression studies have been conducted.	3,4-dichloroaniline	127-134	heme oxygenase 1a	Danio rerio	115-120
18045703-6	2008	Knockdown of gene transcription by siRNA for cyp1a and hmox1 enhanced the frequency of developmental disorders in embryos exposed to 3,4-DCA.	3,4-dichloroaniline	133-140	heme oxygenase 1a	Danio rerio	55-60
33820881-5	2021	Additionally, ALA abolished ROS generation, improved the mitochondrial mass, and enhanced the expression of heme oxygenase-1 (HO-1) and the activation of nuclear translocation of nuclear factor-E2-related factor 2 (Nrf2) in LPS-stimulated RAW 264.7 macrophages.	5-amino levulinic acid	14-17	heme oxygenase 1a	Danio rerio	108-124
33820881-5	2021	Additionally, ALA abolished ROS generation, improved the mitochondrial mass, and enhanced the expression of heme oxygenase-1 (HO-1) and the activation of nuclear translocation of nuclear factor-E2-related factor 2 (Nrf2) in LPS-stimulated RAW 264.7 macrophages.	5-amino levulinic acid	14-17	heme oxygenase 1a	Danio rerio	126-130
33820881-6	2021	However, zinc protoporphyrin, a specific inhibitor of HO-1, reversed the ALA-mediated inhibition of pro-inflammatory cytokines production and activation of mitochondrial function in LPS-treated RAW 264.7 macrophages.	zinc protoporphyrin	9-28	heme oxygenase 1a	Danio rerio	54-58
33820881-6	2021	However, zinc protoporphyrin, a specific inhibitor of HO-1, reversed the ALA-mediated inhibition of pro-inflammatory cytokines production and activation of mitochondrial function in LPS-treated RAW 264.7 macrophages.	5-amino levulinic acid	73-76	heme oxygenase 1a	Danio rerio	54-58
33820881-8	2021	In conclusion, our findings suggest that ALA exerts LPS-induced anti-inflammatory and antioxidant effects by upregulating the Nrf2/HO-1 signaling pathway, and that ALA can be a potential functional agent to prevent inflammatory and oxidative damage.	5-amino levulinic acid	41-44	heme oxygenase 1a	Danio rerio	131-135
33820881-8	2021	In conclusion, our findings suggest that ALA exerts LPS-induced anti-inflammatory and antioxidant effects by upregulating the Nrf2/HO-1 signaling pathway, and that ALA can be a potential functional agent to prevent inflammatory and oxidative damage.	5-amino levulinic acid	164-167	heme oxygenase 1a	Danio rerio	131-135
35142995-8	2022	Our study showed for the first time that 3-pyridinylboronic acid, as a novel sub-class of the heterocyclic boronic acid compound, improved locomotor activities, ameliorated oxidant-antioxidant status by decreasing LPO and NO levels, and normalized the expressions of bdnf, dj1, tnf  and Nrf2 target genes hmox1a and nqo1 in rotenone exposed zebrafish embryos.	3-pyridinylboronic acid	41-64	heme oxygenase 1a	Danio rerio	305-311
35469838-9	2022	Furthermore, rutin treatment also attenuated the genomic expression of oxidative markers (nrf2, hmox1a, sod1, and gpx) and inflammatory genes (il6, tnfa, il10, and irf2a) related to ICH.	Rutin	13-18	heme oxygenase 1a	Danio rerio	96-102
27760386-1	2017	Heme oxygenase 1 (HMOX1) degrades heme into biliverdin, which is subsequently converted to bilirubin by biliverdin reductase (BVRa or BVRb) in a manner analogous to the classic anti-oxidant glutathione-recycling pathway.	Heme	34-38	heme oxygenase 1a	Danio rerio	0-16
31108416-7	2019	These protective activities of chicoric acid were mainly from its alleviation of Pb2+-induced dysregulation of oxidative response pathways, including key genes such as Aox1, Gclm, Hmox1, Nqo1, Scd1, and Srxn1, as well as HO-1 protein.	chicoric acid	31-44	heme oxygenase 1a	Danio rerio	180-185
28212397-5	2017	Both methods showed that exposure to tBHP and Cd induced expression of prdx1, gstp1, and hmox1a (2- to 12-fold increase via QGP), indicative of an activated Nrf2 response in larval zebrafish.	tert-Butylhydroperoxide	37-41	heme oxygenase 1a	Danio rerio	89-95
28212397-5	2017	Both methods showed that exposure to tBHP and Cd induced expression of prdx1, gstp1, and hmox1a (2- to 12-fold increase via QGP), indicative of an activated Nrf2 response in larval zebrafish.	Cadmium	46-48	heme oxygenase 1a	Danio rerio	89-95
35453375-10	2022	L. maackianus MeOH extract induced heme oxygenase-1 expression and increased the translocation of nuclear factor E2-related factor 2 in the nucleus, thus exhibiting antioxidant and anti-inflammatory effects.	Methanol	14-18	heme oxygenase 1a	Danio rerio	35-51
35453375-12	2022	MeOH L. maackianus extract showed antioxidant and anti-neuroinflammatory effects by increasing the expression of heme oxygenase-1, establishing its therapeutic potential for neuroinflammatory diseases.	Methanol	0-4	heme oxygenase 1a	Danio rerio	113-129
27760386-1	2017	Heme oxygenase 1 (HMOX1) degrades heme into biliverdin, which is subsequently converted to bilirubin by biliverdin reductase (BVRa or BVRb) in a manner analogous to the classic anti-oxidant glutathione-recycling pathway.	Heme	34-38	heme oxygenase 1a	Danio rerio	18-23
27760386-1	2017	Heme oxygenase 1 (HMOX1) degrades heme into biliverdin, which is subsequently converted to bilirubin by biliverdin reductase (BVRa or BVRb) in a manner analogous to the classic anti-oxidant glutathione-recycling pathway.	Biliverdine	44-54	heme oxygenase 1a	Danio rerio	0-16
27760386-1	2017	Heme oxygenase 1 (HMOX1) degrades heme into biliverdin, which is subsequently converted to bilirubin by biliverdin reductase (BVRa or BVRb) in a manner analogous to the classic anti-oxidant glutathione-recycling pathway.	Biliverdine	44-54	heme oxygenase 1a	Danio rerio	18-23
27760386-1	2017	Heme oxygenase 1 (HMOX1) degrades heme into biliverdin, which is subsequently converted to bilirubin by biliverdin reductase (BVRa or BVRb) in a manner analogous to the classic anti-oxidant glutathione-recycling pathway.	Bilirubin	91-100	heme oxygenase 1a	Danio rerio	0-16
27760386-1	2017	Heme oxygenase 1 (HMOX1) degrades heme into biliverdin, which is subsequently converted to bilirubin by biliverdin reductase (BVRa or BVRb) in a manner analogous to the classic anti-oxidant glutathione-recycling pathway.	Bilirubin	91-100	heme oxygenase 1a	Danio rerio	18-23
27760386-1	2017	Heme oxygenase 1 (HMOX1) degrades heme into biliverdin, which is subsequently converted to bilirubin by biliverdin reductase (BVRa or BVRb) in a manner analogous to the classic anti-oxidant glutathione-recycling pathway.	Glutathione	190-201	heme oxygenase 1a	Danio rerio	0-16
27760386-1	2017	Heme oxygenase 1 (HMOX1) degrades heme into biliverdin, which is subsequently converted to bilirubin by biliverdin reductase (BVRa or BVRb) in a manner analogous to the classic anti-oxidant glutathione-recycling pathway.	Glutathione	190-201	heme oxygenase 1a	Danio rerio	18-23
27328419-12	2016	VPA inhibits ROS generation by activating the Nrf2/HO-1 pathway, which improves cognitive behavior following radiation-induced neuronal injury.	Reactive Oxygen Species	13-16	heme oxygenase 1a	Danio rerio	51-55
27328419-0	2016	Sodium valproate prevents radiation-induced injury in hippocampal neurons via activation of the Nrf2/HO-1 pathway.	Valproic Acid	0-16	heme oxygenase 1a	Danio rerio	101-105
27671773-2	2016	Heme oxygenase enzymes (HMOX1 and HMOX2) degrade heme into biliverdin and carbon monoxide, with biliverdin subsequently being converted to bilirubin by biliverdin reductase (BVRa or BVRb).	Heme	49-53	heme oxygenase 1a	Danio rerio	24-29
27671773-2	2016	Heme oxygenase enzymes (HMOX1 and HMOX2) degrade heme into biliverdin and carbon monoxide, with biliverdin subsequently being converted to bilirubin by biliverdin reductase (BVRa or BVRb).	Biliverdine	59-69	heme oxygenase 1a	Danio rerio	24-29
27671773-2	2016	Heme oxygenase enzymes (HMOX1 and HMOX2) degrade heme into biliverdin and carbon monoxide, with biliverdin subsequently being converted to bilirubin by biliverdin reductase (BVRa or BVRb).	Carbon Monoxide	74-89	heme oxygenase 1a	Danio rerio	24-29
27671773-2	2016	Heme oxygenase enzymes (HMOX1 and HMOX2) degrade heme into biliverdin and carbon monoxide, with biliverdin subsequently being converted to bilirubin by biliverdin reductase (BVRa or BVRb).	Biliverdine	96-106	heme oxygenase 1a	Danio rerio	24-29
27671773-2	2016	Heme oxygenase enzymes (HMOX1 and HMOX2) degrade heme into biliverdin and carbon monoxide, with biliverdin subsequently being converted to bilirubin by biliverdin reductase (BVRa or BVRb).	Bilirubin	139-148	heme oxygenase 1a	Danio rerio	24-29
27671773-5	2016	hmox1a, hmox2a and hmox2b were significantly induced in male liver tissues in response to 96h cadmium exposure (20muM).	Cadmium	94-101	heme oxygenase 1a	Danio rerio	0-6
27671773-8	2016	Furthermore, hmox1a, hmox1b and bvrb were significantly induced in zebrafish eleutheroembryos in response to multiple pro-oxidants (cadmium, hemin and tert-butylhydroquinone).	Cadmium	132-139	heme oxygenase 1a	Danio rerio	13-19
27671773-8	2016	Furthermore, hmox1a, hmox1b and bvrb were significantly induced in zebrafish eleutheroembryos in response to multiple pro-oxidants (cadmium, hemin and tert-butylhydroquinone).	Hemin	141-146	heme oxygenase 1a	Danio rerio	13-19
27671773-8	2016	Furthermore, hmox1a, hmox1b and bvrb were significantly induced in zebrafish eleutheroembryos in response to multiple pro-oxidants (cadmium, hemin and tert-butylhydroquinone).	2-tert-butylhydroquinone	151-173	heme oxygenase 1a	Danio rerio	13-19
27671773-9	2016	Knockdown of Nrf2a, a transcriptional regulator of hmox1a, was demonstrated to inhibit the Cd-mediated induction of hmox1b and bvrb.	Cadmium	91-93	heme oxygenase 1a	Danio rerio	51-57
25770664-11	2015	Furthermore, the Nrf2-regulated genes gclc, gpx, gstp1, and hmox1 were significantly induced at 24, 48, and 72h at the highest PCB126 exposures but not in the NAC-pretreated group.	3,4,5,3',4'-pentachlorobiphenyl	127-133	heme oxygenase 1a	Danio rerio	60-65
26994186-1	2016	Carbon monoxide (CO) is a gaseous neurotransmitter produced from the breakdown of heme via heme oxygenase-1 (HO-1; hypoxia-inducible isoform) and heme oxygenase-2 (HO-2; constitutively expressed isoform).	Carbon Monoxide	0-15	heme oxygenase 1a	Danio rerio	91-107
26994186-1	2016	Carbon monoxide (CO) is a gaseous neurotransmitter produced from the breakdown of heme via heme oxygenase-1 (HO-1; hypoxia-inducible isoform) and heme oxygenase-2 (HO-2; constitutively expressed isoform).	Carbon Monoxide	17-19	heme oxygenase 1a	Danio rerio	91-107
26994186-1	2016	Carbon monoxide (CO) is a gaseous neurotransmitter produced from the breakdown of heme via heme oxygenase-1 (HO-1; hypoxia-inducible isoform) and heme oxygenase-2 (HO-2; constitutively expressed isoform).	Heme	82-86	heme oxygenase 1a	Danio rerio	91-107
25982796-0	2015	Heme-mediated inhibition of Bach1 regulates the liver specificity and transience of the Nrf2-dependent induction of zebrafish heme oxygenase 1.	Heme	0-4	heme oxygenase 1a	Danio rerio	126-142
25982796-7	2015	Succinylacetone decreased the Nrf2a-mediated hmox1a induction, whereas pre-treatment with hemin caused ectopic induction of hmox1a in nonliver tissues, implying that the high heme levels in the liver may release the repressive activity of Bach1.	succinylacetone	0-15	heme oxygenase 1a	Danio rerio	45-51
25982796-7	2015	Succinylacetone decreased the Nrf2a-mediated hmox1a induction, whereas pre-treatment with hemin caused ectopic induction of hmox1a in nonliver tissues, implying that the high heme levels in the liver may release the repressive activity of Bach1.	Hemin	90-95	heme oxygenase 1a	Danio rerio	124-130
25982796-7	2015	Succinylacetone decreased the Nrf2a-mediated hmox1a induction, whereas pre-treatment with hemin caused ectopic induction of hmox1a in nonliver tissues, implying that the high heme levels in the liver may release the repressive activity of Bach1.	Heme	175-179	heme oxygenase 1a	Danio rerio	124-130
25982796-8	2015	Our results suggested that Bach1 regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 inhibition based on its level in each tissue.	Heme	132-136	heme oxygenase 1a	Danio rerio	116-122
23429283-5	2013	The protection of xyloketal B against angiotensin II-induced apoptosis and reactive oxygen species (ROS) production could be abrogated by the HO-1 specific inhibitor, tin protoporphyrin-IX (SnPP).	Reactive Oxygen Species	75-98	heme oxygenase 1a	Danio rerio	142-146
24905690-9	2014	As2O3 induced toxicity was also validated by the alteration in NRF2 and NRF2 dependent expression of proteins such as heme oxygenase1 (HO1) and NAD(P)H dehydrogenase quinone1 (NQO1).	Arsenic Trioxide	0-5	heme oxygenase 1a	Danio rerio	118-133
24905690-9	2014	As2O3 induced toxicity was also validated by the alteration in NRF2 and NRF2 dependent expression of proteins such as heme oxygenase1 (HO1) and NAD(P)H dehydrogenase quinone1 (NQO1).	Arsenic Trioxide	0-5	heme oxygenase 1a	Danio rerio	135-138
24234649-5	2014	Direct Hmox1 overexpression by injection of zebrafish Hmox1 mRNA into fertilized eggs was found to be sufficient for a dystrophin-independent restoration of normal muscle via an upregulation of cGMP levels.	Cyclic GMP	194-198	heme oxygenase 1a	Danio rerio	7-12
24234649-5	2014	Direct Hmox1 overexpression by injection of zebrafish Hmox1 mRNA into fertilized eggs was found to be sufficient for a dystrophin-independent restoration of normal muscle via an upregulation of cGMP levels.	Cyclic GMP	194-198	heme oxygenase 1a	Danio rerio	54-59
24234649-6	2014	In addition, treatment of mdx(5cv) mice with the PDE5 inhibitor, sildenafil, which was one of the six drugs impacting the Hmox1 pathway in zebrafish, significantly increased the expression of Hmox1 protein, thus making Hmox1 a novel target for the improvement of dystrophic symptoms.	V158411	30-33	heme oxygenase 1a	Danio rerio	192-197
24234649-6	2014	In addition, treatment of mdx(5cv) mice with the PDE5 inhibitor, sildenafil, which was one of the six drugs impacting the Hmox1 pathway in zebrafish, significantly increased the expression of Hmox1 protein, thus making Hmox1 a novel target for the improvement of dystrophic symptoms.	V158411	30-33	heme oxygenase 1a	Danio rerio	192-197
24234649-6	2014	In addition, treatment of mdx(5cv) mice with the PDE5 inhibitor, sildenafil, which was one of the six drugs impacting the Hmox1 pathway in zebrafish, significantly increased the expression of Hmox1 protein, thus making Hmox1 a novel target for the improvement of dystrophic symptoms.	Sildenafil Citrate	65-75	heme oxygenase 1a	Danio rerio	192-197
24234649-6	2014	In addition, treatment of mdx(5cv) mice with the PDE5 inhibitor, sildenafil, which was one of the six drugs impacting the Hmox1 pathway in zebrafish, significantly increased the expression of Hmox1 protein, thus making Hmox1 a novel target for the improvement of dystrophic symptoms.	Sildenafil Citrate	65-75	heme oxygenase 1a	Danio rerio	192-197
23429283-5	2013	The protection of xyloketal B against angiotensin II-induced apoptosis and reactive oxygen species (ROS) production could be abrogated by the HO-1 specific inhibitor, tin protoporphyrin-IX (SnPP).	Reactive Oxygen Species	100-103	heme oxygenase 1a	Danio rerio	142-146
23429283-5	2013	The protection of xyloketal B against angiotensin II-induced apoptosis and reactive oxygen species (ROS) production could be abrogated by the HO-1 specific inhibitor, tin protoporphyrin-IX (SnPP).	tin protoporphyrin IX	167-188	heme oxygenase 1a	Danio rerio	142-146
23429283-5	2013	The protection of xyloketal B against angiotensin II-induced apoptosis and reactive oxygen species (ROS) production could be abrogated by the HO-1 specific inhibitor, tin protoporphyrin-IX (SnPP).	S-Nitroso-N-propionyl-D,L-penicillamine	190-194	heme oxygenase 1a	Danio rerio	142-146
23429283-8	2013	Furthermore, PI3K inhibitor LY294002 and Erk1/2 inhibitor U0126 suppressed the induction of HO-1 and translocation of Nrf-2 by xyloketal B, whereas P38 inhibitor SB203580 did not.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	heme oxygenase 1a	Danio rerio	92-96
23429283-8	2013	Furthermore, PI3K inhibitor LY294002 and Erk1/2 inhibitor U0126 suppressed the induction of HO-1 and translocation of Nrf-2 by xyloketal B, whereas P38 inhibitor SB203580 did not.	U 0126	58-63	heme oxygenase 1a	Danio rerio	92-96
23429283-8	2013	Furthermore, PI3K inhibitor LY294002 and Erk1/2 inhibitor U0126 suppressed the induction of HO-1 and translocation of Nrf-2 by xyloketal B, whereas P38 inhibitor SB203580 did not.	xyloketal B	127-138	heme oxygenase 1a	Danio rerio	92-96
23429283-9	2013	In conclusion, xyloketal B can induce HO-1 expression via PI3K/Akt/Nrf-2 pathways, and the induction of HO-1 is mainly responsible for the antioxidant and antiapoptotic actions of xyloketal B.	xyloketal B	15-26	heme oxygenase 1a	Danio rerio	38-42
23429283-9	2013	In conclusion, xyloketal B can induce HO-1 expression via PI3K/Akt/Nrf-2 pathways, and the induction of HO-1 is mainly responsible for the antioxidant and antiapoptotic actions of xyloketal B.	xyloketal B	180-191	heme oxygenase 1a	Danio rerio	104-108
23174481-6	2013	Zebrafish larvae exposed to Cd for 3h showed increased glutathione S-transferase pi (gst pi), glutamate-cysteine ligase catalytic subunit (gclc), heme oxygenase 1 (hmox1) and peroxiredoxin 1 (prdx1) mRNA levels indicative of Nrf2 activation, and which were blocked by morpholino-mediated Nrf2 knockdown.	Cadmium	28-30	heme oxygenase 1a	Danio rerio	146-162
23174481-6	2013	Zebrafish larvae exposed to Cd for 3h showed increased glutathione S-transferase pi (gst pi), glutamate-cysteine ligase catalytic subunit (gclc), heme oxygenase 1 (hmox1) and peroxiredoxin 1 (prdx1) mRNA levels indicative of Nrf2 activation, and which were blocked by morpholino-mediated Nrf2 knockdown.	Cadmium	28-30	heme oxygenase 1a	Danio rerio	164-169
23174481-6	2013	Zebrafish larvae exposed to Cd for 3h showed increased glutathione S-transferase pi (gst pi), glutamate-cysteine ligase catalytic subunit (gclc), heme oxygenase 1 (hmox1) and peroxiredoxin 1 (prdx1) mRNA levels indicative of Nrf2 activation, and which were blocked by morpholino-mediated Nrf2 knockdown.	Tritium	35-37	heme oxygenase 1a	Danio rerio	146-162
23174481-6	2013	Zebrafish larvae exposed to Cd for 3h showed increased glutathione S-transferase pi (gst pi), glutamate-cysteine ligase catalytic subunit (gclc), heme oxygenase 1 (hmox1) and peroxiredoxin 1 (prdx1) mRNA levels indicative of Nrf2 activation, and which were blocked by morpholino-mediated Nrf2 knockdown.	Tritium	35-37	heme oxygenase 1a	Danio rerio	164-169