PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
35614042-5	2022	Mechanistically, proguanil specifically targeted EGFR and promoted EGFR binding to Caveolin-1, enhanced its endocytosis in a Clathrin-independent manner, and then recruited c-Cbl to promote EGFR ubiquitination and degradation through the lysosomal pathway.	Proguanil	17-26	Cbl proto-oncogene	Homo sapiens	173-178
34173041-9	2021	We also identified cCbl as the E3 ligase of PKG and found that the interaction between these proteins was impaired by TAG-23 treatment.	tag-23	118-124	Cbl proto-oncogene	Homo sapiens	19-23
34173041-11	2021	Our results reveal that a novel exercise-induced peptide, TAG-23, can inhibit PKG degradation by serving as a competitive binding peptide to attenuate the formation of the PKG-cCbl complex.	tag-23	58-64	Cbl proto-oncogene	Homo sapiens	176-180
34132518-10	2021	The intermediate predicted to possess the lowest energy is that resulting from electron transfer from Co(I)Cbl* to the substrate to yield Co(II)Cbl*, a chloride ion, and a vinylic radical.	Chlorides	152-160	Cbl proto-oncogene	Homo sapiens	107-110
34132518-10	2021	The intermediate predicted to possess the lowest energy is that resulting from electron transfer from Co(I)Cbl* to the substrate to yield Co(II)Cbl*, a chloride ion, and a vinylic radical.	Chlorides	152-160	Cbl proto-oncogene	Homo sapiens	144-147
34062268-5	2021	In this framework, phosphorylation of Cbl on tyrosine 774 leads to the interaction with Crk, which acts as a downstream integrator in the CD93-mediated signaling regulating cell polarity and migration.	Tyrosine	45-53	Cbl proto-oncogene	Homo sapiens	38-41
34386951-1	2021	Vitamin B12 (cobalamin, Cbl) is an essential nutrient for all mammals and some bacteria.	Vitamin B 12	0-11	Cbl proto-oncogene	Homo sapiens	24-27
34386951-1	2021	Vitamin B12 (cobalamin, Cbl) is an essential nutrient for all mammals and some bacteria.	Vitamin B 12	13-22	Cbl proto-oncogene	Homo sapiens	24-27
35618206-1	2022	The cblC disease is an inborn disorder of the vitamin B12 (cobalamin, Cbl) metabolism characterized by methylmalonic aciduria and homocystinuria.	Vitamin B 12	46-57	Cbl proto-oncogene	Homo sapiens	70-73
35217034-10	2022	LYN binding to CBL enhanced CBLY731 phosphorylation, CBL-PI3K p85alpha interactivity, AktS473 phosphorylation, and NFkappaB-induced inflammatory marker expression but did not impact membrane GLUT4 translocation.	cbly731	28-35	Cbl proto-oncogene	Homo sapiens	15-18
34132518-7	2021	Notably, the norpseudo-cob(II)alamin (Co(II)Cbl*) cofactor remains five-coordinate upon binding of the substrate to the enzyme, retaining a loosely bound water on the lower face.	norpseudo-cob(ii)alamin	13-36	Cbl proto-oncogene	Homo sapiens	44-47
35061353-4	2022	While the initial step in the catalytic cycle of QueG likely involves the formation of a reduced Co(I)Cbl species, the mechanisms employed by this enzyme to accomplish the thermodynamically challenging reduction of base-off Co(II)Cbl to Co(I)Cbl and to convert oQ to Q remain unknown.	co(ii)cbl	224-233	Cbl proto-oncogene	Homo sapiens	102-105
35354799-8	2022	Further extensive experiments revealed that Cbl-b mediated K27-linked ubiquitination of lysine 164 of STAT5a while c-Cbl induced K29-linked ubiquitination of lysine 696 of STAT5a and K27-linked ubiquitination of lysine 140 and 694 of STAT5b.	Lysine	88-94	Cbl proto-oncogene	Homo sapiens	115-120
35354799-8	2022	Further extensive experiments revealed that Cbl-b mediated K27-linked ubiquitination of lysine 164 of STAT5a while c-Cbl induced K29-linked ubiquitination of lysine 696 of STAT5a and K27-linked ubiquitination of lysine 140 and 694 of STAT5b.	Lysine	158-164	Cbl proto-oncogene	Homo sapiens	115-120
35354799-8	2022	Further extensive experiments revealed that Cbl-b mediated K27-linked ubiquitination of lysine 164 of STAT5a while c-Cbl induced K29-linked ubiquitination of lysine 696 of STAT5a and K27-linked ubiquitination of lysine 140 and 694 of STAT5b.	Lysine	212-218	Cbl proto-oncogene	Homo sapiens	115-120
35495581-11	2022	Conclusion: Visualization of the wire recrossing point and the SB-jailing strut pattern by OCT plays an important role to optimize the KBT in CBL stenting, resulting in favorable mid-term vascular healing.	Antimony	63-65	Cbl proto-oncogene	Homo sapiens	142-145
35309168-7	2022	Lico A promoted the interaction between c-Met and E3 ligase c-Casitas B-lineage lymphoma (Cbl), which enhanced c-Cbl-mediated c-Met ubiquitination and degradation.	licochalcone A	0-6	Cbl proto-oncogene	Homo sapiens	60-88
35309168-7	2022	Lico A promoted the interaction between c-Met and E3 ligase c-Casitas B-lineage lymphoma (Cbl), which enhanced c-Cbl-mediated c-Met ubiquitination and degradation.	licochalcone A	0-6	Cbl proto-oncogene	Homo sapiens	90-93
35309168-7	2022	Lico A promoted the interaction between c-Met and E3 ligase c-Casitas B-lineage lymphoma (Cbl), which enhanced c-Cbl-mediated c-Met ubiquitination and degradation.	licochalcone A	0-6	Cbl proto-oncogene	Homo sapiens	111-116
34998158-0	2022	The CBL-LSD1-CXCL8 axis regulates methionine metabolism in glioma.	Methionine	34-44	Cbl proto-oncogene	Homo sapiens	4-7
34998158-10	2022	Taken together, these findings indicate that the CBL/LSD1/CXCL8 axis is a novel mechanistic connection linking between methionine metabolism, histone methylation and glycerophospholipid reprogramming in the tumor microenvironment.	Methionine	119-129	Cbl proto-oncogene	Homo sapiens	49-52
34998158-10	2022	Taken together, these findings indicate that the CBL/LSD1/CXCL8 axis is a novel mechanistic connection linking between methionine metabolism, histone methylation and glycerophospholipid reprogramming in the tumor microenvironment.	Glycerophospholipids	166-185	Cbl proto-oncogene	Homo sapiens	49-52
35061353-4	2022	While the initial step in the catalytic cycle of QueG likely involves the formation of a reduced Co(I)Cbl species, the mechanisms employed by this enzyme to accomplish the thermodynamically challenging reduction of base-off Co(II)Cbl to Co(I)Cbl and to convert oQ to Q remain unknown.	co(i)cbl	237-245	Cbl proto-oncogene	Homo sapiens	102-105
35061353-4	2022	While the initial step in the catalytic cycle of QueG likely involves the formation of a reduced Co(I)Cbl species, the mechanisms employed by this enzyme to accomplish the thermodynamically challenging reduction of base-off Co(II)Cbl to Co(I)Cbl and to convert oQ to Q remain unknown.	Nucleoside Q	267-268	Cbl proto-oncogene	Homo sapiens	102-105
35337623-1	2022	Vitamin B12 (cobalamin, Cbl, B12) is a water-soluble micronutrient synthesized exclusively by a group of microorganisms.	Vitamin B 12	0-11	Cbl proto-oncogene	Homo sapiens	24-32
35337623-1	2022	Vitamin B12 (cobalamin, Cbl, B12) is a water-soluble micronutrient synthesized exclusively by a group of microorganisms.	Vitamin B 12	13-22	Cbl proto-oncogene	Homo sapiens	24-32
35337630-2	2022	Severe vitamin B12 (Cobalamin-Cbl) deficiency or defective cobalamin metabolism, particularly defects in intracellular B12 metabolism, may lead to a TMA-like picture.	Vitamin B 12	7-18	Cbl proto-oncogene	Homo sapiens	30-33
35337623-1	2022	Vitamin B12 (cobalamin, Cbl, B12) is a water-soluble micronutrient synthesized exclusively by a group of microorganisms.	Water	39-44	Cbl proto-oncogene	Homo sapiens	24-32
501204-6	1979	During the first 48 hr after intake, the injected Cbl remained mostly as cyanocobalamin.	Vitamin B 12	73-87	Cbl proto-oncogene	Homo sapiens	50-53
3194435-6	1988	The TC II did not act by enhanced induction of the Cbl-dependent methionine synthase activity of cell extracts but the ability of intact cells to produce Met from Hcy by the Cbl-dependent process appeared to have a role in the TC II effect.	Homocysteine	163-166	Cbl proto-oncogene	Homo sapiens	174-177
2995422-0	1985	The metabolism of cobalamin bound to transcobalamin II and to glycoproteins that bind Cbl in HepG2 cells (human hepatoma).	Vitamin B 12	18-27	Cbl proto-oncogene	Homo sapiens	86-89
2995422-1	1985	The binding, internalization, processing and release of labeled cyanocobalamin (CN[57Co]Cbl) bound to human transcobalamin II (TC II) were studied in HepG2 cells, a line of hepatocytes derived from a human hepatoma.	Vitamin B 12	64-78	Cbl proto-oncogene	Homo sapiens	88-91
2995422-3	1985	Within the cell, the CN-Cbl was promptly freed from TC II and the CN-Cbl converted to more active forms including adenosyl Cbl (AdoCbl) and methyl Cbl (MeCbl).	MeCbl	152-157	Cbl proto-oncogene	Homo sapiens	24-27
2995422-3	1985	Within the cell, the CN-Cbl was promptly freed from TC II and the CN-Cbl converted to more active forms including adenosyl Cbl (AdoCbl) and methyl Cbl (MeCbl).	MeCbl	152-157	Cbl proto-oncogene	Homo sapiens	69-72
2995422-3	1985	Within the cell, the CN-Cbl was promptly freed from TC II and the CN-Cbl converted to more active forms including adenosyl Cbl (AdoCbl) and methyl Cbl (MeCbl).	MeCbl	152-157	Cbl proto-oncogene	Homo sapiens	69-72
2995422-3	1985	Within the cell, the CN-Cbl was promptly freed from TC II and the CN-Cbl converted to more active forms including adenosyl Cbl (AdoCbl) and methyl Cbl (MeCbl).	MeCbl	152-157	Cbl proto-oncogene	Homo sapiens	69-72
2995422-4	1985	Whereas free labeled Cbl was still present at 72 hours after entry, the cells also bound Cbl to an intracellular binder (ICB) presumed to represent the holo enzymes dependent on Cbl.	indole-2-carboxylic acid	121-124	Cbl proto-oncogene	Homo sapiens	89-92
2995422-4	1985	Whereas free labeled Cbl was still present at 72 hours after entry, the cells also bound Cbl to an intracellular binder (ICB) presumed to represent the holo enzymes dependent on Cbl.	indole-2-carboxylic acid	121-124	Cbl proto-oncogene	Homo sapiens	89-92
2995422-7	1985	Human R type binders of Cbl, which are glycoproteins and some having a terminal galactose, were bound by the HepG2 cells.	Galactose	80-89	Cbl proto-oncogene	Homo sapiens	24-27
3987096-3	1985	The surface density of carboxyl group of N-acetylneuraminic acid (NANA), protein side chain epsilon-amino groups, and phosphate groups were different for the two subpopulations of CBL.	N-Acetylneuraminic Acid	41-64	Cbl proto-oncogene	Homo sapiens	180-183
3987096-3	1985	The surface density of carboxyl group of N-acetylneuraminic acid (NANA), protein side chain epsilon-amino groups, and phosphate groups were different for the two subpopulations of CBL.	Phosphates	118-127	Cbl proto-oncogene	Homo sapiens	180-183
6692038-1	1984	Hydroxocobalamin (OH-Cbl), when used to treat vitamin B12 deficiency, is better retained by the body than is cyanocobalamin (CN-Cbl), but the availability to cells has not been studied systematically.	Hydroxocobalamin	0-16	Cbl proto-oncogene	Homo sapiens	21-24
6844342-2	1983	Mammalian holo TC IIs (CN[57Co]Cbl-TC II) exhibited species variability in their affinity for the hydrophobic matrix in the order: dog greater than mouse greater than human greater than rat greater than rabbit.	holo	10-14	Cbl proto-oncogene	Homo sapiens	31-34
6844342-2	1983	Mammalian holo TC IIs (CN[57Co]Cbl-TC II) exhibited species variability in their affinity for the hydrophobic matrix in the order: dog greater than mouse greater than human greater than rat greater than rabbit.	tc iis	15-21	Cbl proto-oncogene	Homo sapiens	31-34
6844342-4	1983	Phenyl-Sepharose chromatography of CN[57Co]Cbl-labeled rabbit serum (holo TC II) and the unlabeled serum (apo TC II) showed apo TC II to be more hydrophobic than holo TC II as has been shown for human TC II (Begley et al., Biochem Biophys Res Commun 103:434-441, 1981).	phenyl-sepharose	0-16	Cbl proto-oncogene	Homo sapiens	43-46
6844342-4	1983	Phenyl-Sepharose chromatography of CN[57Co]Cbl-labeled rabbit serum (holo TC II) and the unlabeled serum (apo TC II) showed apo TC II to be more hydrophobic than holo TC II as has been shown for human TC II (Begley et al., Biochem Biophys Res Commun 103:434-441, 1981).	Cobalt-57	38-42	Cbl proto-oncogene	Homo sapiens	43-46
7019262-1	1981	Since the presence of analogues of vitamin B12 (B12, cobalamin, Cbl) has been postulated as the basis for the high values obtained by some radioisotope dilution assays (RIDA) of serum Cbl we examined serum for analogues.	Vitamin B 12	35-46	Cbl proto-oncogene	Homo sapiens	64-67
7019262-1	1981	Since the presence of analogues of vitamin B12 (B12, cobalamin, Cbl) has been postulated as the basis for the high values obtained by some radioisotope dilution assays (RIDA) of serum Cbl we examined serum for analogues.	Vitamin B 12	35-46	Cbl proto-oncogene	Homo sapiens	184-187
7019262-3	1981	The natural forms of serum Cbl were converted to cyanocobalamin (CN Cbl) by this process of extraction which included cyanide (CN).	Vitamin B 12	49-63	Cbl proto-oncogene	Homo sapiens	27-30
7019262-3	1981	The natural forms of serum Cbl were converted to cyanocobalamin (CN Cbl) by this process of extraction which included cyanide (CN).	Vitamin B 12	49-63	Cbl proto-oncogene	Homo sapiens	68-71
7019262-3	1981	The natural forms of serum Cbl were converted to cyanocobalamin (CN Cbl) by this process of extraction which included cyanide (CN).	Cyanides	118-125	Cbl proto-oncogene	Homo sapiens	27-30
7019262-3	1981	The natural forms of serum Cbl were converted to cyanocobalamin (CN Cbl) by this process of extraction which included cyanide (CN).	Cyanides	118-125	Cbl proto-oncogene	Homo sapiens	68-71
7019262-3	1981	The natural forms of serum Cbl were converted to cyanocobalamin (CN Cbl) by this process of extraction which included cyanide (CN).	Cyanides	65-67	Cbl proto-oncogene	Homo sapiens	27-30
7019262-3	1981	The natural forms of serum Cbl were converted to cyanocobalamin (CN Cbl) by this process of extraction which included cyanide (CN).	Cyanides	65-67	Cbl proto-oncogene	Homo sapiens	68-71
6256639-1	1980	Membrane transport of vitamin B12 (cyanocobalamin; Cbl) into mammalian cells is mediated by the serum protein transcobalamin II (TCII).	Vitamin B 12	35-49	Cbl proto-oncogene	Homo sapiens	51-54
6774168-2	1980	Transfusion of hydroxocobalamin (OH-Cbl) bound to normal plasma temporarily restored granulocyte bactericidal activity and increased cellular levels of the cobalamin coenzymes.	Hydroxocobalamin	15-31	Cbl proto-oncogene	Homo sapiens	36-39
6775148-3	1980	These results suggest that there may be a close link between TC II-mediated cobalamin transport and intracellular synthesis of adenosylcobalamin (Ado-Cbl).	Vitamin B 12	76-85	Cbl proto-oncogene	Homo sapiens	150-153
6775148-3	1980	These results suggest that there may be a close link between TC II-mediated cobalamin transport and intracellular synthesis of adenosylcobalamin (Ado-Cbl).	cobamamide	127-144	Cbl proto-oncogene	Homo sapiens	150-153
3589492-2	1987	Compared with the original homogenate, adenosyl-cobalamin (Ado-Cbl) was concentrated 5-10 times in the mitochondrial fraction.	cobamamide	39-57	Cbl proto-oncogene	Homo sapiens	63-66
3589492-4	1987	Methyl-cobalamin (Me-Cbl) was found only in the sap fraction and could not be detected in the total homogenate.	mecobalamin	0-16	Cbl proto-oncogene	Homo sapiens	21-24
3589492-5	1987	Hydroxocobalamin was the main form of Cbl in the lysosomal fraction.	Hydroxocobalamin	0-16	Cbl proto-oncogene	Homo sapiens	38-41
3964227-1	1986	Electrophoresis and subsequent autoradiography of 57Co-cobalamin (57 Co-Cbl)-labeled serum show intensity differences between the genetic variants of human transcobalamin II (TC2), suggesting differences in the unsaturated (apo-) TC2 concentration.	57co-cobalamin	50-64	Cbl proto-oncogene	Homo sapiens	72-75
6133033-7	1982	Addition of OH-Cbl to the culture medium improved overall propionate metabolism in intact fibroblasts but had no effect on mutase activity in cell extracts.	Propionates	58-68	Cbl proto-oncogene	Homo sapiens	15-18
7342493-2	1981	Congenital deficiencies of Transcobalamin II (TC II) and R binders of vitamin B12 (B12, cobalamin, Cbl) have been described in several families.	zwittergent 3-12	78-81	Cbl proto-oncogene	Homo sapiens	99-102
7282599-6	1981	Methylcobalamin was the most abundant Cbl of milk.	mecobalamin	0-15	Cbl proto-oncogene	Homo sapiens	38-41
33197049-7	2021	RAS/CBL mutations predicted resistance to ruxolitinib therapy.	ruxolitinib	42-53	Cbl proto-oncogene	Homo sapiens	4-7
963297-1	1976	The uptake of 57Co-cyanocobalamin (CN-Cbl) and its conversion to 5-deoxyadenosylcobalamin (Ado-Cbl), methylcobalamin (Me-Cbl), and hydroxocobalamin (OH-Cbl) has been studied in phytohemagglutinin (PHA)-transformed lymphocytes from normal subjects and patients with patients with pernicious anemia.	57co-cyanocobalamin	14-33	Cbl proto-oncogene	Homo sapiens	38-41
963297-1	1976	The uptake of 57Co-cyanocobalamin (CN-Cbl) and its conversion to 5-deoxyadenosylcobalamin (Ado-Cbl), methylcobalamin (Me-Cbl), and hydroxocobalamin (OH-Cbl) has been studied in phytohemagglutinin (PHA)-transformed lymphocytes from normal subjects and patients with patients with pernicious anemia.	57co-cyanocobalamin	14-33	Cbl proto-oncogene	Homo sapiens	95-98
963297-1	1976	The uptake of 57Co-cyanocobalamin (CN-Cbl) and its conversion to 5-deoxyadenosylcobalamin (Ado-Cbl), methylcobalamin (Me-Cbl), and hydroxocobalamin (OH-Cbl) has been studied in phytohemagglutinin (PHA)-transformed lymphocytes from normal subjects and patients with patients with pernicious anemia.	57co-cyanocobalamin	14-33	Cbl proto-oncogene	Homo sapiens	95-98
963297-1	1976	The uptake of 57Co-cyanocobalamin (CN-Cbl) and its conversion to 5-deoxyadenosylcobalamin (Ado-Cbl), methylcobalamin (Me-Cbl), and hydroxocobalamin (OH-Cbl) has been studied in phytohemagglutinin (PHA)-transformed lymphocytes from normal subjects and patients with patients with pernicious anemia.	57co-cyanocobalamin	14-33	Cbl proto-oncogene	Homo sapiens	95-98
963297-1	1976	The uptake of 57Co-cyanocobalamin (CN-Cbl) and its conversion to 5-deoxyadenosylcobalamin (Ado-Cbl), methylcobalamin (Me-Cbl), and hydroxocobalamin (OH-Cbl) has been studied in phytohemagglutinin (PHA)-transformed lymphocytes from normal subjects and patients with patients with pernicious anemia.	cobamamide	65-89	Cbl proto-oncogene	Homo sapiens	38-41
963297-1	1976	The uptake of 57Co-cyanocobalamin (CN-Cbl) and its conversion to 5-deoxyadenosylcobalamin (Ado-Cbl), methylcobalamin (Me-Cbl), and hydroxocobalamin (OH-Cbl) has been studied in phytohemagglutinin (PHA)-transformed lymphocytes from normal subjects and patients with patients with pernicious anemia.	cobamamide	65-89	Cbl proto-oncogene	Homo sapiens	95-98
963297-1	1976	The uptake of 57Co-cyanocobalamin (CN-Cbl) and its conversion to 5-deoxyadenosylcobalamin (Ado-Cbl), methylcobalamin (Me-Cbl), and hydroxocobalamin (OH-Cbl) has been studied in phytohemagglutinin (PHA)-transformed lymphocytes from normal subjects and patients with patients with pernicious anemia.	cobamamide	65-89	Cbl proto-oncogene	Homo sapiens	95-98
963297-1	1976	The uptake of 57Co-cyanocobalamin (CN-Cbl) and its conversion to 5-deoxyadenosylcobalamin (Ado-Cbl), methylcobalamin (Me-Cbl), and hydroxocobalamin (OH-Cbl) has been studied in phytohemagglutinin (PHA)-transformed lymphocytes from normal subjects and patients with patients with pernicious anemia.	cobamamide	65-89	Cbl proto-oncogene	Homo sapiens	95-98
963297-1	1976	The uptake of 57Co-cyanocobalamin (CN-Cbl) and its conversion to 5-deoxyadenosylcobalamin (Ado-Cbl), methylcobalamin (Me-Cbl), and hydroxocobalamin (OH-Cbl) has been studied in phytohemagglutinin (PHA)-transformed lymphocytes from normal subjects and patients with patients with pernicious anemia.	mecobalamin	101-116	Cbl proto-oncogene	Homo sapiens	38-41
963297-1	1976	The uptake of 57Co-cyanocobalamin (CN-Cbl) and its conversion to 5-deoxyadenosylcobalamin (Ado-Cbl), methylcobalamin (Me-Cbl), and hydroxocobalamin (OH-Cbl) has been studied in phytohemagglutinin (PHA)-transformed lymphocytes from normal subjects and patients with patients with pernicious anemia.	Hydroxocobalamin	131-147	Cbl proto-oncogene	Homo sapiens	38-41
963297-6	1976	Folic acid and methyltetrahydrofolate enhanced synthesis of Me-Cbl both in normal and in PA cells, while methotrexate and 5-fluorouracil depressed it.	Folic Acid	0-10	Cbl proto-oncogene	Homo sapiens	63-66
963297-6	1976	Folic acid and methyltetrahydrofolate enhanced synthesis of Me-Cbl both in normal and in PA cells, while methotrexate and 5-fluorouracil depressed it.	methyltetrahydrofolate	15-37	Cbl proto-oncogene	Homo sapiens	63-66
963297-7	1976	This depression was overcome by 5-formyltetrahydrofolate, suggesting that an uninterrupted folate cycle may play an important role in Me-Cbl synthesis.	Leucovorin	32-56	Cbl proto-oncogene	Homo sapiens	137-140
963297-7	1976	This depression was overcome by 5-formyltetrahydrofolate, suggesting that an uninterrupted folate cycle may play an important role in Me-Cbl synthesis.	Folic Acid	50-56	Cbl proto-oncogene	Homo sapiens	137-140
33996800-6	2021	We further demonstrate that ZNRF1 and Casitas B-lineage lymphoma (CBL), another E3 ubiquitin ligase responsible for EGFR ubiquitination, mediate ubiquitination at distinct lysine residues on EGFR.	Lysine	172-178	Cbl proto-oncogene	Homo sapiens	66-69
33512474-6	2021	Signaling adaptor domains of CBL, including the tyrosine-kinase binding domain, proline-rich region, and C-terminal phosphotyrosine sites, were all required for the oncogenic function of CBL mutants.	Proline	80-87	Cbl proto-oncogene	Homo sapiens	29-32
33512474-6	2021	Signaling adaptor domains of CBL, including the tyrosine-kinase binding domain, proline-rich region, and C-terminal phosphotyrosine sites, were all required for the oncogenic function of CBL mutants.	Proline	80-87	Cbl proto-oncogene	Homo sapiens	187-190
33512474-6	2021	Signaling adaptor domains of CBL, including the tyrosine-kinase binding domain, proline-rich region, and C-terminal phosphotyrosine sites, were all required for the oncogenic function of CBL mutants.	Phosphotyrosine	116-131	Cbl proto-oncogene	Homo sapiens	29-32
33512474-6	2021	Signaling adaptor domains of CBL, including the tyrosine-kinase binding domain, proline-rich region, and C-terminal phosphotyrosine sites, were all required for the oncogenic function of CBL mutants.	Phosphotyrosine	116-131	Cbl proto-oncogene	Homo sapiens	187-190
33512474-7	2021	Genetic ablation or dasatinib-mediated inhibition of LYN reduced CBL phosphorylation, CBL-PIK3R1 interaction, and PI3K/AKT signaling.	Dasatinib	20-29	Cbl proto-oncogene	Homo sapiens	65-68
33512474-7	2021	Genetic ablation or dasatinib-mediated inhibition of LYN reduced CBL phosphorylation, CBL-PIK3R1 interaction, and PI3K/AKT signaling.	Dasatinib	20-29	Cbl proto-oncogene	Homo sapiens	86-89
33512474-8	2021	Furthermore, we demonstrated in vitro and in vivo antiproliferative efficacy of dasatinib in CBL-mutant cell lines and primary CMML.	Dasatinib	80-89	Cbl proto-oncogene	Homo sapiens	93-96
33617900-6	2021	This SLAP2 binding site is remote from the canonical TKBD phospho-tyrosine peptide binding site but overlaps with a region important for stabilizing CBL in its autoinhibited conformation.	Tyrosine	66-74	Cbl proto-oncogene	Homo sapiens	149-152
33669415-5	2021	AL530 released PD98059+CBL-A at mild acidic pH and in vitro was fivefold more potent than CBL and three-to-fivefold more potent than CBL+PD98059.	al530	0-5	Cbl proto-oncogene	Homo sapiens	23-26
33669415-5	2021	AL530 released PD98059+CBL-A at mild acidic pH and in vitro was fivefold more potent than CBL and three-to-fivefold more potent than CBL+PD98059.	al530	0-5	Cbl proto-oncogene	Homo sapiens	90-93
33669415-5	2021	AL530 released PD98059+CBL-A at mild acidic pH and in vitro was fivefold more potent than CBL and three-to-fivefold more potent than CBL+PD98059.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	15-22	Cbl proto-oncogene	Homo sapiens	90-93
33669415-5	2021	AL530 released PD98059+CBL-A at mild acidic pH and in vitro was fivefold more potent than CBL and three-to-fivefold more potent than CBL+PD98059.	cbl-a	23-28	Cbl proto-oncogene	Homo sapiens	90-93
33620036-2	2021	In contrast to the phosphotyrosine-dependent binding of CBL substrates through its tyrosine kinase-binding domain (TKBD), CBL TKBD associates with the C-terminal tail of SLAP2 in a phospho-independent manner.	Phosphotyrosine	19-34	Cbl proto-oncogene	Homo sapiens	56-59
33421903-0	2021	Saikosaponin a contributed to CCIN treatment by promoting neutrophil bactericidal activity via activation CBL-dependent ERK pathway.	saikosaponin D	0-14	Cbl proto-oncogene	Homo sapiens	106-109
33421903-0	2021	Saikosaponin a contributed to CCIN treatment by promoting neutrophil bactericidal activity via activation CBL-dependent ERK pathway.	ccin	30-34	Cbl proto-oncogene	Homo sapiens	106-109
43301-4	1979	Postmortem analysis of liver obtained 2 weeks after the child was treated with vitamin B12 revealed deficient activity of both cobalamin dependent enzymes: N5-methyltetrahydrofolate: homocysteine methyltransferase (requiring Me-Cbl), and methylmalonyl CoA mutase (requiring Ado-Cbl).	Vitamin B 12	79-90	Cbl proto-oncogene	Homo sapiens	228-231
43301-4	1979	Postmortem analysis of liver obtained 2 weeks after the child was treated with vitamin B12 revealed deficient activity of both cobalamin dependent enzymes: N5-methyltetrahydrofolate: homocysteine methyltransferase (requiring Me-Cbl), and methylmalonyl CoA mutase (requiring Ado-Cbl).	Vitamin B 12	79-90	Cbl proto-oncogene	Homo sapiens	278-281
43301-4	1979	Postmortem analysis of liver obtained 2 weeks after the child was treated with vitamin B12 revealed deficient activity of both cobalamin dependent enzymes: N5-methyltetrahydrofolate: homocysteine methyltransferase (requiring Me-Cbl), and methylmalonyl CoA mutase (requiring Ado-Cbl).	Vitamin B 12	127-136	Cbl proto-oncogene	Homo sapiens	228-231
43301-4	1979	Postmortem analysis of liver obtained 2 weeks after the child was treated with vitamin B12 revealed deficient activity of both cobalamin dependent enzymes: N5-methyltetrahydrofolate: homocysteine methyltransferase (requiring Me-Cbl), and methylmalonyl CoA mutase (requiring Ado-Cbl).	Vitamin B 12	127-136	Cbl proto-oncogene	Homo sapiens	278-281
43301-8	1979	This suggests that at least some of the CN-Cbl administered was converted to the coenzymes in liver which would explain the reduction of MMA- and HCy-excretion during therapy.	mma	137-140	Cbl proto-oncogene	Homo sapiens	43-46
43301-9	1979	The results show 1. that this infant suffered from a congenital defect in one of the steps of intracellular cobalamin metabolism or transport common to the synthesis of both coenzymes, 2. that life-long treatment with vitamin B12 (OH-Cbl) may be of value in similar cases, particularly if given early in the course of the disease.	Vitamin B 12	108-117	Cbl proto-oncogene	Homo sapiens	234-237
43301-9	1979	The results show 1. that this infant suffered from a congenital defect in one of the steps of intracellular cobalamin metabolism or transport common to the synthesis of both coenzymes, 2. that life-long treatment with vitamin B12 (OH-Cbl) may be of value in similar cases, particularly if given early in the course of the disease.	Vitamin B 12	218-229	Cbl proto-oncogene	Homo sapiens	234-237
418497-2	1978	Plasma total cobalamin was lower in myeloma patients than in either of the control groups and methylcobalamin (Me-Cbl) was disproportionately reduced.	mecobalamin	94-109	Cbl proto-oncogene	Homo sapiens	114-117
921081-5	1977	Radioactivity of cobamide zones from duplicate chromatograms showed bacterial conversion of (57Co)-cn-cbl into cobamides.	Cobamides	17-25	Cbl proto-oncogene	Homo sapiens	102-105
921081-5	1977	Radioactivity of cobamide zones from duplicate chromatograms showed bacterial conversion of (57Co)-cn-cbl into cobamides.	Cobamides	111-120	Cbl proto-oncogene	Homo sapiens	102-105
921081-6	1977	Cobamides ([Ade]CNCBA, [2-Me Ade] CNCba, [CN]2Cbi and factor E) were found in the intestinal contents in three of the four patients, and in two of three patients cobamides represented more than 25% of the administered CN-Cbl.	Cobamides	0-9	Cbl proto-oncogene	Homo sapiens	221-224
921081-7	1977	Thus bacterial production of cobamides, both de novo and from ingested CN-Cbl bound to intrinsic factor, occurs in humans with bacterial overgrowth states and results in a significant loss of vitamin B12 to the host.	Cobamides	29-38	Cbl proto-oncogene	Homo sapiens	74-77
921081-7	1977	Thus bacterial production of cobamides, both de novo and from ingested CN-Cbl bound to intrinsic factor, occurs in humans with bacterial overgrowth states and results in a significant loss of vitamin B12 to the host.	Vitamin B 12	192-203	Cbl proto-oncogene	Homo sapiens	74-77
339529-2	1977	Difluoro chlor methylcobalamine (CF2Cl-Cbl) exhibited the most distinct inhibitory effect on growth of bacterial cells in the medium with cobalamine.	difluoro chlor methylcobalamine	0-31	Cbl proto-oncogene	Homo sapiens	39-42
339529-2	1977	Difluoro chlor methylcobalamine (CF2Cl-Cbl) exhibited the most distinct inhibitory effect on growth of bacterial cells in the medium with cobalamine.	Vitamin B 12	21-31	Cbl proto-oncogene	Homo sapiens	39-42
5651012-1	1968	Structure of mycoside Cbl].	mycoside	13-21	Cbl proto-oncogene	Homo sapiens	22-25
33627783-9	2021	Inhibition of the CBL-CIN85 interaction with a proline-rich peptide of CBL that binds CIN85 reduced the proliferation of MDA-MB-231 cells.	Proline	47-54	Cbl proto-oncogene	Homo sapiens	18-21
33627783-9	2021	Inhibition of the CBL-CIN85 interaction with a proline-rich peptide of CBL that binds CIN85 reduced the proliferation of MDA-MB-231 cells.	Proline	47-54	Cbl proto-oncogene	Homo sapiens	71-74
33388664-0	2021	Emerging roles of the CBL-CIPK calcium signaling network as key regulatory hub in plant nutrition.	Calcium	31-38	Cbl proto-oncogene	Homo sapiens	22-25
33050187-4	2020	Previously, we developed an in vitro model of cobalamin deficiency in normal human astrocytes (NHA) by culturing the cells with c-lactam of hydroxycobalamin (c-lactam OH-Cbl).	Vitamin B 12	46-55	Cbl proto-oncogene	Homo sapiens	170-173
33325453-9	2020	CONCLUSIONS: The diagnostic evaluation of a LEC has to include the possibility of a concurrent EMZL, mainly in case of high risk biological and clinical conditions like CBL.	emzl	95-99	Cbl proto-oncogene	Homo sapiens	169-172
33272295-5	2020	HDL was isolated from plasma samples, and the concentration of HDL carbamyl-lysine (HDL-CBL) was measured.	carbamyl-lysine	67-82	Cbl proto-oncogene	Homo sapiens	88-91
33288568-3	2020	We have previously demonstrated the anti-tumor activity of a nitric oxide-donor, nitrosylcobalamin (NO-Cbl), mediated by increased expression of tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) and its receptors in human tumors.	Nitric Oxide	61-73	Cbl proto-oncogene	Homo sapiens	103-106
33288568-3	2020	We have previously demonstrated the anti-tumor activity of a nitric oxide-donor, nitrosylcobalamin (NO-Cbl), mediated by increased expression of tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) and its receptors in human tumors.	nitrosylcobalamin	81-98	Cbl proto-oncogene	Homo sapiens	103-106
33231565-5	2020	CBL silencing led to an enhancement of cell proliferation and DNA synthesis and neutralized the effect of miRNA-122-5p inhibitor on the DNA synthesis of human SSCs.	mirna-122-5p	106-118	Cbl proto-oncogene	Homo sapiens	0-3
32898552-1	2020	Cellular uptake of vitamin B12 (cobalamin, Cbl) is mediated by a cell surface receptor (TCblR/CD320) that binds transcobalamin (TC) saturated with Cbl.	Vitamin B 12	32-41	Cbl proto-oncogene	Homo sapiens	89-92
33867334-9	2020	Ciprofloxacin -G2 dendrimer conjugate was able to increase Bcl-2/Bax ratio in a large scale as compared with the control group and CBL alone.	Ciprofloxacin	0-13	Cbl proto-oncogene	Homo sapiens	131-134
32822868-0	2020	Saikosaponin d contributed to cancer chemotherapy induced neutropenia therapy by promoting neutrophil differentiation via activation CBL-dependent ERK pathway.	saikosaponin D	0-14	Cbl proto-oncogene	Homo sapiens	133-136
32898552-1	2020	Cellular uptake of vitamin B12 (cobalamin, Cbl) is mediated by a cell surface receptor (TCblR/CD320) that binds transcobalamin (TC) saturated with Cbl.	Vitamin B 12	19-30	Cbl proto-oncogene	Homo sapiens	43-46
32898552-1	2020	Cellular uptake of vitamin B12 (cobalamin, Cbl) is mediated by a cell surface receptor (TCblR/CD320) that binds transcobalamin (TC) saturated with Cbl.	Vitamin B 12	19-30	Cbl proto-oncogene	Homo sapiens	89-92
32898552-1	2020	Cellular uptake of vitamin B12 (cobalamin, Cbl) is mediated by a cell surface receptor (TCblR/CD320) that binds transcobalamin (TC) saturated with Cbl.	Vitamin B 12	32-41	Cbl proto-oncogene	Homo sapiens	43-46
33050333-7	2020	In addition, DEX decreased protein stability of DR5 via GSK-3beta-mediated upregulation of Cbl, an E3 ligase of DR5.	Dexamethasone	13-16	Cbl proto-oncogene	Homo sapiens	91-94
33050333-8	2020	Knockdown of Cbl by siRNA markedly inhibited DEX-induced DR5 downregulation.	Dexamethasone	45-48	Cbl proto-oncogene	Homo sapiens	13-16
33023511-10	2020	After being diagnosed, she was treated with intramuscular 1 mg hydroxycobalamin (OH-Cbl) every day for 2 months.	Hydroxocobalamin	63-79	Cbl proto-oncogene	Homo sapiens	84-87
33050187-4	2020	Previously, we developed an in vitro model of cobalamin deficiency in normal human astrocytes (NHA) by culturing the cells with c-lactam of hydroxycobalamin (c-lactam OH-Cbl).	c-lactam	128-136	Cbl proto-oncogene	Homo sapiens	170-173
33050187-4	2020	Previously, we developed an in vitro model of cobalamin deficiency in normal human astrocytes (NHA) by culturing the cells with c-lactam of hydroxycobalamin (c-lactam OH-Cbl).	Hydroxocobalamin	140-156	Cbl proto-oncogene	Homo sapiens	170-173
33050187-4	2020	Previously, we developed an in vitro model of cobalamin deficiency in normal human astrocytes (NHA) by culturing the cells with c-lactam of hydroxycobalamin (c-lactam OH-Cbl).	c-lactam	158-166	Cbl proto-oncogene	Homo sapiens	170-173
32815652-1	2020	BACKGROUND: In humans, absorption and tissue retention rates of intramuscularly administered hydroxocobalamin (OH-Cbl) are superior compared to cyanocobalamin (CN-Cbl).	Hydroxocobalamin	93-109	Cbl proto-oncogene	Homo sapiens	114-117
32388477-1	2020	HYPOTHESIS: Abnormal movements such as tremor, myoclonus, and choreoathetosis due to infantile nutritional vitamin B12 (Cbl, cobalamin) deficiency or after Cbl injection have been recognized for many years.	Vitamin B 12	107-118	Cbl proto-oncogene	Homo sapiens	120-123
32388477-1	2020	HYPOTHESIS: Abnormal movements such as tremor, myoclonus, and choreoathetosis due to infantile nutritional vitamin B12 (Cbl, cobalamin) deficiency or after Cbl injection have been recognized for many years.	Vitamin B 12	125-134	Cbl proto-oncogene	Homo sapiens	156-159
32825566-7	2020	Taken together, these results provide the first evidence that IITZ-01 enhances TRAIL-mediated apoptosis through DR5 stabilization by downregulation of Cbl and USP9X-dependent survivin ubiquitination and degradation in renal carcinoma cells.	IITZ-01	62-69	Cbl proto-oncogene	Homo sapiens	151-154
32289469-2	2020	The endogenous synthesis of methionine is catalyzed by methionine synthase, which transfers the methyl group of 5-methyltetrahydrofolate (5-methylTHF) to homocysteine in the presence of vitamin B12 (cobalamin, cbl).	Methionine	28-38	Cbl proto-oncogene	Homo sapiens	210-213
32720950-1	2020	We report a two-photon responsive drug delivery system (DDS), namely, p-hydroxyphenacyl-naphthalene-chlorambucil (pHP-Naph-Cbl), having a two-photon absorption (TPA) cross-section of >=20 GM in the phototherapeutic window (700 nm).	Chlorambucil	100-112	Cbl proto-oncogene	Homo sapiens	123-126
32720950-1	2020	We report a two-photon responsive drug delivery system (DDS), namely, p-hydroxyphenacyl-naphthalene-chlorambucil (pHP-Naph-Cbl), having a two-photon absorption (TPA) cross-section of >=20 GM in the phototherapeutic window (700 nm).	Tetradecanoylphorbol Acetate	161-164	Cbl proto-oncogene	Homo sapiens	123-126
32707731-3	2020	Here, we showed that Cbl dampened NLRP3 inflammasome activation by inhibiting glycolysis, as demonstrated with Cbl knockout cells and treatment with the Cbl inhibitor hydrocotarnine.	hydrocotarnine	167-181	Cbl proto-oncogene	Homo sapiens	21-24
32707731-5	2020	Inhibiting Cbl increased cellular glucose uptake, glycolytic capacity, and mitochondrial oxidative phosphorylation capacity.	Glucose	34-41	Cbl proto-oncogene	Homo sapiens	11-14
32707731-6	2020	Upon NLRP3 inflammasome activation, inhibiting Cbl increased glycolysis-dependent activation of mitochondrial respiration and increased the production of reactive oxygen species, which contributes to NLRP3 inflammasome activation and IL-1beta secretion.	Oxygen	163-169	Cbl proto-oncogene	Homo sapiens	47-50
32707731-7	2020	Mechanistically, inhibiting Cbl increased surface expression of glucose transporter 1 (GLUT1) protein through post-transcriptional regulation, which increased cellular glucose uptake and consequently raised glycolytic capacity, and in turn enhanced NLRP3 inflammasome activation.	Glucose	64-71	Cbl proto-oncogene	Homo sapiens	28-31
32707731-9	2020	We also show that a novel Cbl inhibitor, hydrocortanine, increased NLRP3 inflammasome activity via its effect on glycolysis.	hydrocortanine	41-55	Cbl proto-oncogene	Homo sapiens	26-29
32720950-1	2020	We report a two-photon responsive drug delivery system (DDS), namely, p-hydroxyphenacyl-naphthalene-chlorambucil (pHP-Naph-Cbl), having a two-photon absorption (TPA) cross-section of >=20 GM in the phototherapeutic window (700 nm).	p-hydroxyphenacyl-naphthalene	70-99	Cbl proto-oncogene	Homo sapiens	123-126
32410120-9	2020	DECA may promote glioma cell apoptosis by affecting the expression of NFKB2, HRAS, NF1, CBL, RAF1, and BCL-2 genes.	decabromobiphenyl ether	0-4	Cbl proto-oncogene	Homo sapiens	88-91
32032659-3	2020	Roscovitine co-treatment enhanced ATRA-induced expression of pS259- pS289/296/301- pS621-c-Raf, pS217/221-Mek, Src Family Kinases (SFKs) Lyn and Fgr and SFK Y416 phosphorylation, adaptor proteins c-Cbl and Slp-76, Vav, and acetylated 14-3-3 in the signalsome.	roscovitine	0-11	Cbl proto-oncogene	Homo sapiens	196-201
32032659-3	2020	Roscovitine co-treatment enhanced ATRA-induced expression of pS259- pS289/296/301- pS621-c-Raf, pS217/221-Mek, Src Family Kinases (SFKs) Lyn and Fgr and SFK Y416 phosphorylation, adaptor proteins c-Cbl and Slp-76, Vav, and acetylated 14-3-3 in the signalsome.	Tretinoin	34-38	Cbl proto-oncogene	Homo sapiens	196-201
32032659-4	2020	Roscovitine enhanced ATRA-induced c-Raf interaction with Lyn, Vav, and c-Cbl.	roscovitine	0-11	Cbl proto-oncogene	Homo sapiens	71-76
32032659-4	2020	Roscovitine enhanced ATRA-induced c-Raf interaction with Lyn, Vav, and c-Cbl.	Tretinoin	21-25	Cbl proto-oncogene	Homo sapiens	71-76
32377695-7	2020	PLAG accelerated the assembly of EGFRs with c-Cbl and EPS15 and promoted receptor degradation.	1-palmitoyl-2-linoleoyl-3-acetyl-rac glycerol	0-4	Cbl proto-oncogene	Homo sapiens	44-49
32289469-2	2020	The endogenous synthesis of methionine is catalyzed by methionine synthase, which transfers the methyl group of 5-methyltetrahydrofolate (5-methylTHF) to homocysteine in the presence of vitamin B12 (cobalamin, cbl).	5-methyltetrahydrofolate	112-136	Cbl proto-oncogene	Homo sapiens	210-213
32289469-2	2020	The endogenous synthesis of methionine is catalyzed by methionine synthase, which transfers the methyl group of 5-methyltetrahydrofolate (5-methylTHF) to homocysteine in the presence of vitamin B12 (cobalamin, cbl).	5-methyltetrahydrofolate	138-149	Cbl proto-oncogene	Homo sapiens	210-213
32289469-2	2020	The endogenous synthesis of methionine is catalyzed by methionine synthase, which transfers the methyl group of 5-methyltetrahydrofolate (5-methylTHF) to homocysteine in the presence of vitamin B12 (cobalamin, cbl).	Homocysteine	154-166	Cbl proto-oncogene	Homo sapiens	210-213
32289469-2	2020	The endogenous synthesis of methionine is catalyzed by methionine synthase, which transfers the methyl group of 5-methyltetrahydrofolate (5-methylTHF) to homocysteine in the presence of vitamin B12 (cobalamin, cbl).	Vitamin B 12	186-197	Cbl proto-oncogene	Homo sapiens	210-213
32452532-8	2020	Among CBL-On patients, the >=50% reduction in seizure frequency was found in 52.9% and 27.8% in the CBD and placebo groups, respectively (RR = 1.85, 95% CI = 1.40-2.44, P < .001).	Cannabidiol	100-103	Cbl proto-oncogene	Homo sapiens	6-9
32111094-7	2020	We demonstrated that local delivery of gemcitabine using GEM implants inhibited tumor cell growth by promoting c-CBL-mediated degradation of EGFR and inhibiting the proliferation, angiogenesis, and epithelial-mesenchymal transition of pancreatic/biliary tumors.	gemcitabine	39-50	Cbl proto-oncogene	Homo sapiens	111-116
32217102-9	2020	Furthermore, ECG and EGCG dimers increased EGFR phosphorylation at Tyr1045 residue, providing a docking site for ubiquitin ligase c-Cbl and induced EGFR degradation by the proteasome.	epicatechin gallate	13-16	Cbl proto-oncogene	Homo sapiens	130-135
32217102-9	2020	Furthermore, ECG and EGCG dimers increased EGFR phosphorylation at Tyr1045 residue, providing a docking site for ubiquitin ligase c-Cbl and induced EGFR degradation by the proteasome.	epigallocatechin gallate	21-25	Cbl proto-oncogene	Homo sapiens	130-135
32202904-13	2020	And the protein of apoptosis-related proteins including PARP, caspase-3, caspase-7, caspase-8, and caspase-9 were increased in CBL group compared with NC group (P < 0.05), while the NF-kappaB, p-NF-kappaB and p-AKT expression levels were significantly downregulated following CBL0137 treatment (P < 0.05).	CBLC137	276-283	Cbl proto-oncogene	Homo sapiens	127-130
31901557-3	2020	In this study, Sp-CBL containing CBL-N, CBL-2, CBL-3 and RING domains was identified in mud crab Scylla paramamosain.	Nitrogen	37-38	Cbl proto-oncogene	Homo sapiens	18-21
31901557-3	2020	In this study, Sp-CBL containing CBL-N, CBL-2, CBL-3 and RING domains was identified in mud crab Scylla paramamosain.	Nitrogen	37-38	Cbl proto-oncogene	Homo sapiens	33-36
31901557-3	2020	In this study, Sp-CBL containing CBL-N, CBL-2, CBL-3 and RING domains was identified in mud crab Scylla paramamosain.	Nitrogen	37-38	Cbl proto-oncogene	Homo sapiens	33-36
31901557-3	2020	In this study, Sp-CBL containing CBL-N, CBL-2, CBL-3 and RING domains was identified in mud crab Scylla paramamosain.	Nitrogen	37-38	Cbl proto-oncogene	Homo sapiens	33-36
32231253-2	2020	We have discovered a calcium (Ca2+)-dependent signalling network, consisting of two calcineurin B-like (CBL) Ca2+ sensors and a quartet of CBL-interacting protein kinases (CIPKs), which plays a key role in plant response to K+ starvation.	Calcium	21-28	Cbl proto-oncogene	Homo sapiens	84-102
32231253-2	2020	We have discovered a calcium (Ca2+)-dependent signalling network, consisting of two calcineurin B-like (CBL) Ca2+ sensors and a quartet of CBL-interacting protein kinases (CIPKs), which plays a key role in plant response to K+ starvation.	Calcium	21-28	Cbl proto-oncogene	Homo sapiens	104-107
32256976-8	2020	Roscovitine also enhanced the ATRA-induced nuclear enrichment of other signaling molecules traditionally perceived as cytoplasmic promoters of proliferation, but now known to promote differentiation; in particular: SFKs, Lyn, Fgr; adaptor proteins, c-Cbl, SLP-76; a guanine exchange factor, Vav1; and a transcription factor, IRF-1.	Roscovitine	0-11	Cbl proto-oncogene	Homo sapiens	249-254
32256976-8	2020	Roscovitine also enhanced the ATRA-induced nuclear enrichment of other signaling molecules traditionally perceived as cytoplasmic promoters of proliferation, but now known to promote differentiation; in particular: SFKs, Lyn, Fgr; adaptor proteins, c-Cbl, SLP-76; a guanine exchange factor, Vav1; and a transcription factor, IRF-1.	Tretinoin	30-34	Cbl proto-oncogene	Homo sapiens	249-254
32111094-7	2020	We demonstrated that local delivery of gemcitabine using GEM implants inhibited tumor cell growth by promoting c-CBL-mediated degradation of EGFR and inhibiting the proliferation, angiogenesis, and epithelial-mesenchymal transition of pancreatic/biliary tumors.	4-(N)-lauroylgemcitabine	57-60	Cbl proto-oncogene	Homo sapiens	111-116
31976317-0	2019	MiR-486-5p Suppresses Proliferation and Migration of Hepatocellular Carcinoma Cells through Downregulation of the E3 Ubiquitin Ligase CBL.	mir-486-5p	0-10	Cbl proto-oncogene	Homo sapiens	134-137
31902683-2	2020	Severe acquired vitamin B12 (Cobalamin - Cbl) deficiency or congenital defective Cbl metabolism could lead to a picture that mimics TMA.	Vitamin B 12	29-38	Cbl proto-oncogene	Homo sapiens	41-44
31785807-0	2020	Flavone inhibited proliferation of T-ALL by promoting c-Cbl-induced ubiquitinylation and degradation of Notch1.	flavone	0-7	Cbl proto-oncogene	Homo sapiens	54-59
31785807-8	2020	Flavone-mediated upregulation of c-Cbl level results in the increase in its interaction with ICN1, further caused ICN1 ubiquitinylation and degradation.	flavone	0-7	Cbl proto-oncogene	Homo sapiens	33-38
31785807-9	2020	Knockdown of c-Cbl reversed flavone-induced down-regulation of ICN1 and inhibition of cell proliferation in T-ALL cells.	flavone	28-35	Cbl proto-oncogene	Homo sapiens	13-18
31785807-10	2020	In short, this study indicated that flavone exerted resistance to T-ALL by promoting c-Cbl-induced ubiquitinylation and degradation of ICN1.	flavone	36-43	Cbl proto-oncogene	Homo sapiens	85-90
31943762-6	2020	Here, we show that targeted SYK inhibition similarly enhances the effects of midostaurin and other FLT3 inhibitors against mutant CBL-positive leukaemia.	midostaurin	77-88	Cbl proto-oncogene	Homo sapiens	130-133
31809977-0	2020	Clinical response to crizotinib and emergence of resistance in lung adenocarcinoma harboring a MET c-Cbl binding site mutation.	Crizotinib	21-31	Cbl proto-oncogene	Homo sapiens	101-104
31809977-3	2020	RESULTS: We report the case of a patient with metastastic lung adenocarcinoma harboring a c-Cbl binding site alteration and demonstrate clinical, radiological and metabolic response to crizotinib with a PFS of 10.6 months.	Crizotinib	185-195	Cbl proto-oncogene	Homo sapiens	90-95
31976317-7	2019	The E3 ubiquitin ligase CBL was significantly downregulated by miR-486-5p overexpression in HCC cell lines at both mRNA and protein level, and overexpression of CBL counteracted the inhibitory effects of miR-486-5p on HCC cell proliferation and migration.	mir-486-5p	63-73	Cbl proto-oncogene	Homo sapiens	24-27
31976317-7	2019	The E3 ubiquitin ligase CBL was significantly downregulated by miR-486-5p overexpression in HCC cell lines at both mRNA and protein level, and overexpression of CBL counteracted the inhibitory effects of miR-486-5p on HCC cell proliferation and migration.	mir-486-5p	204-214	Cbl proto-oncogene	Homo sapiens	24-27
31976317-7	2019	The E3 ubiquitin ligase CBL was significantly downregulated by miR-486-5p overexpression in HCC cell lines at both mRNA and protein level, and overexpression of CBL counteracted the inhibitory effects of miR-486-5p on HCC cell proliferation and migration.	mir-486-5p	204-214	Cbl proto-oncogene	Homo sapiens	161-164
31976317-9	2019	Collectively, our results suggest that miR-486-5p may act as a tumor suppressor gene in HCC by downregulating CBL expression.	mir-486-5p	39-49	Cbl proto-oncogene	Homo sapiens	110-113
31324852-6	2019	HPASMC with combined exposure to cocaine and Tat (C + T) vs control identified the following top lncRNA-mRNA pairs, ENST00000495536-HOXB13, T216482-CBL, ENST00000602736-GDF7, and, TCONS_00020413-RND1.	Cocaine	33-40	Cbl proto-oncogene	Homo sapiens	148-151
31756921-3	2019	Four major classes of enzymes that attenuate TCR signaling include E3 ubiquitin kinases such as the Casitas B-lineage lymphoma proteins (Cbl-b and c-Cbl), and Itchy (Itch), inhibitory tyrosine phosphatases, such as Src homology region 2 domain-containing phosphatases (SHP-1 and SHP-2), inhibitory protein kinases, such as C-terminal Src kinase (Csk), and inhibitory lipid kinases such as Src homology 2 (SH2) domain-containing inositol polyphosphate 5-phosphatase (SHIP) and Diacylglycerol kinases (DGKs).	Carbon	46-47	Cbl proto-oncogene	Homo sapiens	147-152
31484920-13	2019	This study also suggests that a combination of doxazosin and other EPHA2 inhibitors directed to inhibit the pertinent signaling components may be a novel therapeutic strategy for MPM and Non-small cell lung cancer patients who have either EPHA2 or CBL alterations.	Doxazosin	47-56	Cbl proto-oncogene	Homo sapiens	248-251
31438886-12	2019	Furthermore, we have noticed that after carbon ion irradiation, circRNA CBL.11 was increased in CRC cells and could function as a competing endogenous RNA (ceRNA) to regulate YWHAE expression by sponging miR-6778-5p, resulting in regulation the proliferation of CRC cells.	Carbon	40-46	Cbl proto-oncogene	Homo sapiens	72-75
31438886-13	2019	CONCLUSION: CircRNA CBL.11 may play an important role in improving the efficacy of carbon ion RT against CRC.	Carbon	83-89	Cbl proto-oncogene	Homo sapiens	20-23
31123954-1	2019	PURPOSE: Vitamin B12 (cobalamin, Cbl) plays a role in the recycling of folate, which is important in pregnancy.	Vitamin B 12	9-20	Cbl proto-oncogene	Homo sapiens	33-36
31123954-1	2019	PURPOSE: Vitamin B12 (cobalamin, Cbl) plays a role in the recycling of folate, which is important in pregnancy.	Folic Acid	71-77	Cbl proto-oncogene	Homo sapiens	33-36
29884903-7	2019	Conversely, JAK/STAT signaling was selectively activated in CBL iPSCs and abrogated by the JAKi momelotinib and ruxolitinib.	N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide	96-107	Cbl proto-oncogene	Homo sapiens	60-63
30693532-1	2019	Vitamin B12 (cobalamin, Cbl) is a nutrient essential to human health.	Vitamin B 12	0-11	Cbl proto-oncogene	Homo sapiens	24-27
30693532-4	2019	Methionine synthase catalyzes the methyl-Cbl dependent (re)methylation of homocysteine to methionine within the methionine cycle; a reaction required to produce this essential amino acid and generate S-adenosylmethionine, the most important cellular methyl-donor.	Homocysteine	74-86	Cbl proto-oncogene	Homo sapiens	41-44
30693532-4	2019	Methionine synthase catalyzes the methyl-Cbl dependent (re)methylation of homocysteine to methionine within the methionine cycle; a reaction required to produce this essential amino acid and generate S-adenosylmethionine, the most important cellular methyl-donor.	Methionine	90-100	Cbl proto-oncogene	Homo sapiens	41-44
30693532-4	2019	Methionine synthase catalyzes the methyl-Cbl dependent (re)methylation of homocysteine to methionine within the methionine cycle; a reaction required to produce this essential amino acid and generate S-adenosylmethionine, the most important cellular methyl-donor.	Methionine	112-122	Cbl proto-oncogene	Homo sapiens	41-44
30693532-4	2019	Methionine synthase catalyzes the methyl-Cbl dependent (re)methylation of homocysteine to methionine within the methionine cycle; a reaction required to produce this essential amino acid and generate S-adenosylmethionine, the most important cellular methyl-donor.	Amino Acids, Essential	166-186	Cbl proto-oncogene	Homo sapiens	41-44
30693532-4	2019	Methionine synthase catalyzes the methyl-Cbl dependent (re)methylation of homocysteine to methionine within the methionine cycle; a reaction required to produce this essential amino acid and generate S-adenosylmethionine, the most important cellular methyl-donor.	S-Adenosylmethionine	200-220	Cbl proto-oncogene	Homo sapiens	41-44
30693532-8	2019	It also provides a description of folate-mediated one-carbon metabolism and its intersection with Cbl at the methionine cycle.	Folic Acid	34-40	Cbl proto-oncogene	Homo sapiens	98-101
30693532-8	2019	It also provides a description of folate-mediated one-carbon metabolism and its intersection with Cbl at the methionine cycle.	Carbon	54-60	Cbl proto-oncogene	Homo sapiens	98-101
30693532-8	2019	It also provides a description of folate-mediated one-carbon metabolism and its intersection with Cbl at the methionine cycle.	Methionine	109-119	Cbl proto-oncogene	Homo sapiens	98-101
31157807-7	2019	The direct effect of the aggregate structure of P3HT on the functional operation of GO as a HTL or CBL thus establishes clear criteria towards the rational design of improved organic optoelectronic devices.	p3ht	48-52	Cbl proto-oncogene	Homo sapiens	99-102
31120930-3	2019	RF E3s, such as the Cbl proteins, interact with a ubiquitin-conjugating enzyme (E2) to confer specificity to the ubiquitination process and direct the transfer of ubiquitin from the E2 to one or more lysines on the target proteins.	Lysine	200-207	Cbl proto-oncogene	Homo sapiens	20-23
31120930-5	2019	Phosphorylation of the Cbl protein by by Src resulted in increased E3 activity compared to unphosphorylated cbl or Cbl containing a phosphomimetic Y371E mutation.	Chlorambucil	108-111	Cbl proto-oncogene	Homo sapiens	23-26
31123462-7	2019	Results: Here, we report on a form of TRAF6 ubiquitination that is mediated by c-Cbl, leading to the formation of lysine 48-linked polyubiquitin chains.	Lysine	114-120	Cbl proto-oncogene	Homo sapiens	79-84
31123462-11	2019	Fine mapping revealed that the proline-rich domain of c-Cbl is critical for interaction with TRAF6.	Proline	31-38	Cbl proto-oncogene	Homo sapiens	54-59
31123462-13	2019	Conclusions: These findings indicate that the interaction of TRAF6 with c-Cbl causes lysine 48-linked polyubiquitination for both negative feedback regulation and signaling cross-talk between RANKL and IFN-gamma.	Lysine	85-91	Cbl proto-oncogene	Homo sapiens	72-77
30614340-0	2019	Ascorbic acid improves thrombotic function of platelets during living donor liver transplantation by modulating the function of the E3 ubiquitin ligases c-Cbl and Cbl-b.	Ascorbic Acid	0-13	Cbl proto-oncogene	Homo sapiens	153-158
30733293-5	2019	The cannabinoid Delta9-tetrahydrocannabinol (THC) disrupts HER2-CB2R complexes by selectively binding to CB2R, which leads to (i) the inactivation of HER2 through disruption of HER2-HER2 homodimers, and (ii) the subsequent degradation of HER2 by the proteasome via the E3 ligase c-CBL.	Cannabinoids	4-15	Cbl proto-oncogene	Homo sapiens	279-284
30733293-5	2019	The cannabinoid Delta9-tetrahydrocannabinol (THC) disrupts HER2-CB2R complexes by selectively binding to CB2R, which leads to (i) the inactivation of HER2 through disruption of HER2-HER2 homodimers, and (ii) the subsequent degradation of HER2 by the proteasome via the E3 ligase c-CBL.	Dronabinol	16-43	Cbl proto-oncogene	Homo sapiens	279-284
30733293-5	2019	The cannabinoid Delta9-tetrahydrocannabinol (THC) disrupts HER2-CB2R complexes by selectively binding to CB2R, which leads to (i) the inactivation of HER2 through disruption of HER2-HER2 homodimers, and (ii) the subsequent degradation of HER2 by the proteasome via the E3 ligase c-CBL.	Dronabinol	45-48	Cbl proto-oncogene	Homo sapiens	279-284
29884903-7	2019	Conversely, JAK/STAT signaling was selectively activated in CBL iPSCs and abrogated by the JAKi momelotinib and ruxolitinib.	ruxolitinib	112-123	Cbl proto-oncogene	Homo sapiens	60-63
29306994-1	2018	OBJECTIVE: Exclusively breast-fed infants born to vitamin B12 (cobalamin, cbl)-deficient mothers can develop symptoms within a few months following delivery.	Vitamin B 12	50-61	Cbl proto-oncogene	Homo sapiens	74-77
30581774-0	2018	Curaxin CBL0137 Exerts Anticancer Activity via Diverse Mechanisms.	curaxin	0-7	Cbl proto-oncogene	Homo sapiens	8-11
29306994-9	2018	In the correlational analysis between maternal and infantile markers associated with cbl status, the strongest correlation was observed between maternal holoTC and infantile tHcy (r = -0.49, p &lt; 0.001), followed by the correlation between maternal tHcy and infantile tHcy (r = 0.47, p &lt; 0.001).	thcy	174-178	Cbl proto-oncogene	Homo sapiens	85-88
29306994-12	2018	Both maternal holoTC and tHcy may assist in predicting infantile cbl status.	thcy	25-29	Cbl proto-oncogene	Homo sapiens	65-68
29498203-4	2018	Uniquely revealed for a high-performance model PSC are the often overlooked porosity distributions of the ZnO-based CBL and the differential diffusions of the polymer PTB7-Th and fullerene derivative PC71 BM of the active layer into the CBL.	Zinc Oxide	106-109	Cbl proto-oncogene	Homo sapiens	116-119
29498046-3	2018	Through bioinformatics analyses, we determined that among plant protein kinase families, the occurrence of motifs indicative for dual lipidation by N-myristoylation and S-acylation is restricted to only five kinase families, including the Ca2+ -regulated CDPK-SnRK and CBL protein families.	Nitrogen	148-149	Cbl proto-oncogene	Homo sapiens	269-272
29498112-2	2018	Human Cbl proteins are activated by tyrosine phosphorylation, thus setting up a feedback loop whereby the activation of tyrosine kinases triggers their own degradation.	Tyrosine	36-44	Cbl proto-oncogene	Homo sapiens	6-9
29498112-3	2018	Cbl proteins are targeted to their substrates by a phosphotyrosine-binding SH2 domain.	Phosphotyrosine	51-66	Cbl proto-oncogene	Homo sapiens	0-3
29498112-9	2018	Our results indicate that for both human and S. rosetta Cbl, ubiquitylation depends on proximity and accessibility, rather than being targeted toward specific lysine residues.	Lysine	159-165	Cbl proto-oncogene	Homo sapiens	56-59
29553742-5	2018	We demonstrate this by studying deacylation and reverse acylation reactions of aztreonam drug catalyzed by a class-C beta lactamase (CBL) bacterial enzyme.	Aztreonam	79-88	Cbl proto-oncogene	Homo sapiens	109-131
29553742-5	2018	We demonstrate this by studying deacylation and reverse acylation reactions of aztreonam drug catalyzed by a class-C beta lactamase (CBL) bacterial enzyme.	Aztreonam	79-88	Cbl proto-oncogene	Homo sapiens	133-136
29553742-6	2018	Mechanistic details and nature of kinetics of aztreonam hydrolysis by CBL are elaborated here.	Aztreonam	46-55	Cbl proto-oncogene	Homo sapiens	70-73
29720121-0	2018	C-Cbl reverses HER2-mediated tamoxifen resistance in human breast cancer cells.	Tamoxifen	29-38	Cbl proto-oncogene	Homo sapiens	0-5
29720121-15	2018	In addition, c-Cbl could reverse tamoxifen resistance in BT474 cells, but the ubiquitin ligase mutant had no effect.	Tamoxifen	33-42	Cbl proto-oncogene	Homo sapiens	13-18
29720121-18	2018	CONCLUSIONS: Our results suggested that c-Cbl can reverse tamoxifen resistance in HER2-overexpressing breast cancer cells by inhibiting the formation of the ER-c-Src-HER2 complex.	Tamoxifen	58-67	Cbl proto-oncogene	Homo sapiens	40-45
29435646-6	2018	We propose that under the influence of ascorbic acid, nitrocobalamin is reduced to Cbl(II) and nitric oxide ( NO), which can subsequently react rapidly to form CblNO.	Ascorbic Acid	39-52	Cbl proto-oncogene	Homo sapiens	83-86
29435646-6	2018	We propose that under the influence of ascorbic acid, nitrocobalamin is reduced to Cbl(II) and nitric oxide ( NO), which can subsequently react rapidly to form CblNO.	nitritocobalamin	54-68	Cbl proto-oncogene	Homo sapiens	83-86
29435646-6	2018	We propose that under the influence of ascorbic acid, nitrocobalamin is reduced to Cbl(II) and nitric oxide ( NO), which can subsequently react rapidly to form CblNO.	cblno	160-165	Cbl proto-oncogene	Homo sapiens	83-86
29498203-5	2018	Interface modification of the ZnO-based CBL with fullerene derivative PCBE OH for size-selective nanochannels can selectively improve the diffusion of PC71 BM more than that of the polymer.	Zinc Oxide	30-33	Cbl proto-oncogene	Homo sapiens	40-43
29498203-5	2018	Interface modification of the ZnO-based CBL with fullerene derivative PCBE OH for size-selective nanochannels can selectively improve the diffusion of PC71 BM more than that of the polymer.	Fullerenes	49-58	Cbl proto-oncogene	Homo sapiens	40-43
29498203-6	2018	The deeper penetration of PC71 BM establishes a gradient distribution of fullerene derivatives over the ZnO/PCBE-OH CBL, resulting in markedly improved electron mobility and device efficiency of the inverted PSC.	Zinc Oxide	104-107	Cbl proto-oncogene	Homo sapiens	116-119
29298668-6	2018	The recombinant CBL in the 293F cell culture supernatant was able to inhibit the growth of Rhizoctonia solani and Colletotrichum gloeosporioide.	gloeosporioide	129-143	Cbl proto-oncogene	Homo sapiens	16-19
29298668-8	2018	Binding of CBL to Spodoptera frugiperda (sf21) insect cells can partly be inhibited by N-Acetylglucosamine (GlcNAc), which is related to decrease mitochondrial membrane potential of sf21 cells.	Acetylglucosamine	87-106	Cbl proto-oncogene	Homo sapiens	11-14
29298668-8	2018	Binding of CBL to Spodoptera frugiperda (sf21) insect cells can partly be inhibited by N-Acetylglucosamine (GlcNAc), which is related to decrease mitochondrial membrane potential of sf21 cells.	Acetylglucosamine	108-114	Cbl proto-oncogene	Homo sapiens	11-14
29298668-9	2018	CONCLUSIONS: The results showed that CBL exhibited antifungal properties and inhibited insect cell growth, which is directly correlated to the lectin-carbohydrate interaction.	Carbohydrates	150-162	Cbl proto-oncogene	Homo sapiens	37-40
28538514-1	2017	Cobalamin (vitamin B12 [Cbl]) is an essential cofactor for many biochemical pathways.	Vitamin B 12	11-22	Cbl proto-oncogene	Homo sapiens	24-27
28846104-5	2017	Berberine binding promotes RXRalpha interaction with nuclear beta-catenin, leading to c-Cbl mediated degradation of beta-catenin, and consequently inhibits the proliferation of colon cancer cells.	Berberine	0-9	Cbl proto-oncogene	Homo sapiens	86-91
29153845-1	2017	Vitamin B12 (cobalamin, Cbl) is a micronutrient essential to human health.	Vitamin B 12	0-11	Cbl proto-oncogene	Homo sapiens	24-27
28881087-3	2017	The binding of DNA-Cbl to TC, IF, and HC was investigated in competition with either a fluorescent Cbl derivative and Co-(dN)25 -Cbl, or radiolabeled vitamin B12 (57 Co-CNCbl) and Co-(dN)25 -Cbl or Co-(dN)39 -Cbl.	co-cncbl	166-174	Cbl proto-oncogene	Homo sapiens	19-22
28881087-8	2017	The invariably tight interaction of the DNA-Cbl conjugates with TC makes the Cbl moiety a potential natural vector for the specific delivery of oligonucleotide loads from the blood into cells.	Oligonucleotides	144-159	Cbl proto-oncogene	Homo sapiens	44-47
28881087-8	2017	The invariably tight interaction of the DNA-Cbl conjugates with TC makes the Cbl moiety a potential natural vector for the specific delivery of oligonucleotide loads from the blood into cells.	Oligonucleotides	144-159	Cbl proto-oncogene	Homo sapiens	77-80
28538514-3	2017	Cbl is then processed in the cytoplasm and mitochondria by complementation factors leading to its active metabolites; methylcobalamin and 5-deoxyadenosyl-cobalamin.	mecobalamin	118-133	Cbl proto-oncogene	Homo sapiens	0-3
28538514-3	2017	Cbl is then processed in the cytoplasm and mitochondria by complementation factors leading to its active metabolites; methylcobalamin and 5-deoxyadenosyl-cobalamin.	cobamamide	138-163	Cbl proto-oncogene	Homo sapiens	0-3
29053960-3	2017	Structural and biochemical analyses revealed that UbVs specifically inhibited the activity of UBE4B or phosphorylated CBL by blocking the E2~Ub binding site.	BM	50-52	Cbl proto-oncogene	Homo sapiens	118-121
29153845-6	2017	Thirty-seven mutant ABC transporters were screened for the excretion of methylmalonic acid (MMA), which should result from loss of Cbl transport into the mitochondria.	Methylmalonic Acid	72-90	Cbl proto-oncogene	Homo sapiens	131-134
29153845-6	2017	Thirty-seven mutant ABC transporters were screened for the excretion of methylmalonic acid (MMA), which should result from loss of Cbl transport into the mitochondria.	Methylmalonic Acid	92-95	Cbl proto-oncogene	Homo sapiens	131-134
28667844-1	2017	INTRODUCTION: Both venous thromboembolism (VTE) and high plasma vitamin B12 levels (cobalamin, Cbl) are markers of occult cancer and aggressive cancer with a poor prognosis.	Vitamin B 12	64-75	Cbl proto-oncogene	Homo sapiens	95-98
28891990-3	2017	In this paper, an amine group functionalized fullerene derivative (DMAPA-C60) is used as a CBL to modify the transparent cathode ITO in inverted OSCs based on PTB7 as a donor and PC71BM as an acceptor.	Amines	18-23	Cbl proto-oncogene	Homo sapiens	91-94
28891990-3	2017	In this paper, an amine group functionalized fullerene derivative (DMAPA-C60) is used as a CBL to modify the transparent cathode ITO in inverted OSCs based on PTB7 as a donor and PC71BM as an acceptor.	Fullerenes	45-54	Cbl proto-oncogene	Homo sapiens	91-94
28891990-3	2017	In this paper, an amine group functionalized fullerene derivative (DMAPA-C60) is used as a CBL to modify the transparent cathode ITO in inverted OSCs based on PTB7 as a donor and PC71BM as an acceptor.	dimethylarsinopenicillamine	67-72	Cbl proto-oncogene	Homo sapiens	91-94
28835699-6	2017	sh-RNA-mediated knockdown of CBL enhanced cell motility and colony formation in NSCLC cells, and these activities were inhibited by SU11274.	((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide)	132-139	Cbl proto-oncogene	Homo sapiens	29-32
28835699-8	2017	When CBL was knocked down in the mutant cell line H1975 (erlotinib-resistant), it became sensitive to MET inhibition.	Erlotinib Hydrochloride	57-66	Cbl proto-oncogene	Homo sapiens	5-8
27927016-7	2017	Moreover, ZFL increased the expression of Cbl, an E3 ligase of c-FLIP, in a p53-dependent manner, and knockdown of Cbl markedly prevented c-FLIP downregulation and the apoptosis induced by ZFL plus TRAIL.	zfl	10-13	Cbl proto-oncogene	Homo sapiens	42-45
27927016-11	2017	CONCLUSION: Our results indicated that inhibition of cathepsin S stimulates TRAIL-induced apoptosis through downregulation of Bcl-2 and Cbl-mediated c-FLIP by ROS-mediated p53 expression.	Reactive Oxygen Species	159-162	Cbl proto-oncogene	Homo sapiens	136-139
28676638-8	2017	Using lysine-to-arginine site-directed mutagenesis, K970 in the kinase domain of JAK2 was identified as the ubiquitination site important for promoting full JAK2 activation by Cbl via K63-conjugated poly-ubiquitination.	Lysine	6-12	Cbl proto-oncogene	Homo sapiens	176-179
28676638-8	2017	Using lysine-to-arginine site-directed mutagenesis, K970 in the kinase domain of JAK2 was identified as the ubiquitination site important for promoting full JAK2 activation by Cbl via K63-conjugated poly-ubiquitination.	Arginine	16-24	Cbl proto-oncogene	Homo sapiens	176-179
28100467-4	2017	Using a newly engineered tamoxifen-inducible Cbl and Cbl-b deletion model with a dual fluorescent reporter (Cblflox/flox; Cbl-bflox/flox; Rosa26-CreERT; mT/mG), we show that Cbl/Cbl-b DKO in mammary organoids leads to hyperactivation of AKT-mTOR signaling with depletion of MaSCs.	Tamoxifen	25-34	Cbl proto-oncogene	Homo sapiens	45-48
28611796-0	2017	Identification of Important Physiological Traits and Moderators That Are Associated with Improved Salt Tolerance in CBL and CIPK Overexpressors through a Meta-Analysis.	Salts	98-102	Cbl proto-oncogene	Homo sapiens	116-119
28611796-1	2017	The CBL-CIPK pathway is a plant-specific Ca2+ sensor relaying pathway that has been shown to be involved in plant response to salt stress.	Salts	126-130	Cbl proto-oncogene	Homo sapiens	4-7
28611796-2	2017	Over-expression of CBL-CIPK network genes has been reported to increase salt tolerance in many studies.	Salts	72-76	Cbl proto-oncogene	Homo sapiens	19-22
28415719-3	2017	We demonstrate that the Rab-7 GTPase is a key upstream regulator of late endosomal sorting of tyrosine118-phosphorylated paxillin, which is subsequently recruited to autophagosomes via the cargo receptor c-Cbl.	tyrosine118	94-105	Cbl proto-oncogene	Homo sapiens	204-209
28415719-4	2017	Essentially, this recruitment involves a direct and selective interaction between Y118-phospho-paxillin, c-Cbl, and LC3 and is independent from c-Cbl E3 ubiquitin ligase activity.	y118	82-86	Cbl proto-oncogene	Homo sapiens	105-110
27864634-1	2017	Reactions of aquacobalamin (H2O-Cbl(III)) and its one-electron reduced form (cob(II)alamin, Cbl(II)) with chlorite (ClO2-) and chlorine dioxide (ClO 2  ) were studied by conventional and stopped-flow UV-Vis spectroscopies and matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS).	aquacobalamin	13-26	Cbl proto-oncogene	Homo sapiens	32-35
27864634-1	2017	Reactions of aquacobalamin (H2O-Cbl(III)) and its one-electron reduced form (cob(II)alamin, Cbl(II)) with chlorite (ClO2-) and chlorine dioxide (ClO 2  ) were studied by conventional and stopped-flow UV-Vis spectroscopies and matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS).	aquacobalamin	13-26	Cbl proto-oncogene	Homo sapiens	92-95
27864634-1	2017	Reactions of aquacobalamin (H2O-Cbl(III)) and its one-electron reduced form (cob(II)alamin, Cbl(II)) with chlorite (ClO2-) and chlorine dioxide (ClO 2  ) were studied by conventional and stopped-flow UV-Vis spectroscopies and matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS).	Water	28-31	Cbl proto-oncogene	Homo sapiens	32-35
27864634-1	2017	Reactions of aquacobalamin (H2O-Cbl(III)) and its one-electron reduced form (cob(II)alamin, Cbl(II)) with chlorite (ClO2-) and chlorine dioxide (ClO 2  ) were studied by conventional and stopped-flow UV-Vis spectroscopies and matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS).	chlorite	106-114	Cbl proto-oncogene	Homo sapiens	32-35
27864634-1	2017	Reactions of aquacobalamin (H2O-Cbl(III)) and its one-electron reduced form (cob(II)alamin, Cbl(II)) with chlorite (ClO2-) and chlorine dioxide (ClO 2  ) were studied by conventional and stopped-flow UV-Vis spectroscopies and matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS).	chlorite	106-114	Cbl proto-oncogene	Homo sapiens	92-95
27864634-2	2017	ClO2- does not react with H2O-Cbl(III), but oxidizes Cbl(II) to H2O-Cbl(III) as a major product and corrin-modified species as minor products.	Chlorous acid	0-4	Cbl proto-oncogene	Homo sapiens	53-56
27864634-2	2017	ClO2- does not react with H2O-Cbl(III), but oxidizes Cbl(II) to H2O-Cbl(III) as a major product and corrin-modified species as minor products.	Chlorous acid	0-4	Cbl proto-oncogene	Homo sapiens	53-56
27864634-3	2017	The proposed mechanism of chlorite reduction involves formation of OCl- that modifies the corrin ring during the course of reaction with Cbl(II).	chlorite	26-34	Cbl proto-oncogene	Homo sapiens	137-140
27864634-3	2017	The proposed mechanism of chlorite reduction involves formation of OCl- that modifies the corrin ring during the course of reaction with Cbl(II).	ocl-	67-71	Cbl proto-oncogene	Homo sapiens	137-140
27864634-3	2017	The proposed mechanism of chlorite reduction involves formation of OCl- that modifies the corrin ring during the course of reaction with Cbl(II).	corrin	90-96	Cbl proto-oncogene	Homo sapiens	137-140
27864634-4	2017	H2O-Cbl(III) undergoes relatively slow destruction by ClO 2  via transient formation of oxygenated species, whereas reaction between Cbl(II) and ClO 2  proceeds extremely rapidly and leads to the oxidation of the Co(II)-center.	clo 2	54-59	Cbl proto-oncogene	Homo sapiens	4-7
27864634-4	2017	H2O-Cbl(III) undergoes relatively slow destruction by ClO 2  via transient formation of oxygenated species, whereas reaction between Cbl(II) and ClO 2  proceeds extremely rapidly and leads to the oxidation of the Co(II)-center.	clo 2	145-150	Cbl proto-oncogene	Homo sapiens	4-7
27864634-4	2017	H2O-Cbl(III) undergoes relatively slow destruction by ClO 2  via transient formation of oxygenated species, whereas reaction between Cbl(II) and ClO 2  proceeds extremely rapidly and leads to the oxidation of the Co(II)-center.	clo 2	145-150	Cbl proto-oncogene	Homo sapiens	133-136
27864634-4	2017	H2O-Cbl(III) undergoes relatively slow destruction by ClO 2  via transient formation of oxygenated species, whereas reaction between Cbl(II) and ClO 2  proceeds extremely rapidly and leads to the oxidation of the Co(II)-center.	Cobalt(2+)	213-219	Cbl proto-oncogene	Homo sapiens	4-7
27864634-4	2017	H2O-Cbl(III) undergoes relatively slow destruction by ClO 2  via transient formation of oxygenated species, whereas reaction between Cbl(II) and ClO 2  proceeds extremely rapidly and leads to the oxidation of the Co(II)-center.	Cobalt(2+)	213-219	Cbl proto-oncogene	Homo sapiens	133-136
28611796-3	2017	The studies on the overexpression of CBL-CIPK network genes, however, have used various indices to evaluate the effect of these genes on salt tolerance and have indicated a variety of roles for the major CBL-CIPK pathway genes.	Salts	137-141	Cbl proto-oncogene	Homo sapiens	37-40
28611796-3	2017	The studies on the overexpression of CBL-CIPK network genes, however, have used various indices to evaluate the effect of these genes on salt tolerance and have indicated a variety of roles for the major CBL-CIPK pathway genes.	Salts	137-141	Cbl proto-oncogene	Homo sapiens	204-207
28611796-4	2017	Therefore, it is of great interest to analyze the various effects resulting from the overexpression CBL-CIPK pathway genes and their relation to salt tolerance.	Salts	145-149	Cbl proto-oncogene	Homo sapiens	100-103
28611796-5	2017	The meta-analysis conducted in the present study investigated how over-expression of CBLs or CIPKs in transgenic plants affects the response to salt stress and identified the increase or decrease that occurs in these experimental variables when foreign CIPK or CBL genes are overexpressed in transgenic plants.	Salts	144-148	Cbl proto-oncogene	Homo sapiens	85-88
28611796-11	2017	The results of the meta-analysis provide information that could be useful in designing research to examine the mechanisms by which CBL-CIPK pathway genes increase salt tolerance in plants.	Salts	163-167	Cbl proto-oncogene	Homo sapiens	131-134
27893837-1	2016	Tracking cellular 57Co-labelled cobalamin (57Co-Cbl) uptake is a well-established method for studying Cbl homeostasis.	Cobalt-57	18-22	Cbl proto-oncogene	Homo sapiens	48-51
27370399-11	2017	Intravenous administration of CBL0137 significantly increased survival in models of early- through late-stage TMZ-responsive and -resistant GBM, with a trend toward significantly increasing the effect of TMZ in TMZ-responsive U87MG tumors.	Temozolomide	110-113	Cbl proto-oncogene	Homo sapiens	30-33
27370399-11	2017	Intravenous administration of CBL0137 significantly increased survival in models of early- through late-stage TMZ-responsive and -resistant GBM, with a trend toward significantly increasing the effect of TMZ in TMZ-responsive U87MG tumors.	Temozolomide	204-207	Cbl proto-oncogene	Homo sapiens	30-33
27370399-11	2017	Intravenous administration of CBL0137 significantly increased survival in models of early- through late-stage TMZ-responsive and -resistant GBM, with a trend toward significantly increasing the effect of TMZ in TMZ-responsive U87MG tumors.	Temozolomide	204-207	Cbl proto-oncogene	Homo sapiens	30-33
28286577-0	2017	In vitro and in vivo human metabolism of a new synthetic cannabinoid NM-2201 (CBL-2201).	Cannabinoids	57-68	Cbl proto-oncogene	Homo sapiens	78-81
28286577-0	2017	In vitro and in vivo human metabolism of a new synthetic cannabinoid NM-2201 (CBL-2201).	NM-2201	69-76	Cbl proto-oncogene	Homo sapiens	78-81
28286577-1	2017	In 2014, NM-2201 (CBL-2201), a novel synthetic cannabinoid (SC), was detected by Russian and United States laboratories.	NM-2201	9-16	Cbl proto-oncogene	Homo sapiens	18-21
28286577-1	2017	In 2014, NM-2201 (CBL-2201), a novel synthetic cannabinoid (SC), was detected by Russian and United States laboratories.	Cannabinoids	47-58	Cbl proto-oncogene	Homo sapiens	18-21
27824740-6	2017	We initially treated all patients with intramuscular injections of a maximum of 1 mg cyanocobalamin (CN-Cbl) daily and with a final dose of 1 mg per week.	Vitamin B 12	85-99	Cbl proto-oncogene	Homo sapiens	104-107
27893837-1	2016	Tracking cellular 57Co-labelled cobalamin (57Co-Cbl) uptake is a well-established method for studying Cbl homeostasis.	Cobalt-57	18-22	Cbl proto-oncogene	Homo sapiens	102-105
27893837-1	2016	Tracking cellular 57Co-labelled cobalamin (57Co-Cbl) uptake is a well-established method for studying Cbl homeostasis.	Vitamin B 12	32-41	Cbl proto-oncogene	Homo sapiens	48-51
27893837-1	2016	Tracking cellular 57Co-labelled cobalamin (57Co-Cbl) uptake is a well-established method for studying Cbl homeostasis.	Vitamin B 12	32-41	Cbl proto-oncogene	Homo sapiens	102-105
27612423-9	2016	Erlotinib treatment induced polyubiquitination and proteasomal degradation, primarily in a c-CBL-independent manner, in TKI sensitive L858R and delE746-A750 mutants when compared to the L858R/T790M mutant, which correlated with drug sensitivity.	Erlotinib Hydrochloride	0-9	Cbl proto-oncogene	Homo sapiens	91-96
27725776-7	2016	Tyr phosphorylation of key candidate proteins in these pathways included common gamma-chain of the Fc receptors, Syk, clathrin, E3 ubiquitin protein ligase Cbl, hepatocyte growth factor-regulated tyrosine kinase substrate, tripartite motif-containing 21 and heat shock protein 70.	Tyrosine	0-3	Cbl proto-oncogene	Homo sapiens	156-159
26950611-1	2016	Experiments were conducted to investigate the reductive dechlorination of tetrachloroethylene (PCE) by nano-Mackinawite (nFeS) with cyano-cobalamin (Cbl(III)) in cement slurries.	Tetrachloroethylene	74-93	Cbl proto-oncogene	Homo sapiens	149-152
27567143-1	2016	Kinetic and mechanistic studies on the reaction of a major intracellular vitamin B12 form, cob(II)alamin (Cbl(II)), with hypochlorous acid/hypochlorite (HOCl/OCl-) have been carried out.	Vitamin B 12	73-84	Cbl proto-oncogene	Homo sapiens	106-109
27567143-1	2016	Kinetic and mechanistic studies on the reaction of a major intracellular vitamin B12 form, cob(II)alamin (Cbl(II)), with hypochlorous acid/hypochlorite (HOCl/OCl-) have been carried out.	Hypochlorous Acid	121-138	Cbl proto-oncogene	Homo sapiens	106-109
27567143-1	2016	Kinetic and mechanistic studies on the reaction of a major intracellular vitamin B12 form, cob(II)alamin (Cbl(II)), with hypochlorous acid/hypochlorite (HOCl/OCl-) have been carried out.	Hypochlorous Acid	139-151	Cbl proto-oncogene	Homo sapiens	106-109
27567143-1	2016	Kinetic and mechanistic studies on the reaction of a major intracellular vitamin B12 form, cob(II)alamin (Cbl(II)), with hypochlorous acid/hypochlorite (HOCl/OCl-) have been carried out.	Hypochlorous Acid	153-157	Cbl proto-oncogene	Homo sapiens	106-109
27567143-1	2016	Kinetic and mechanistic studies on the reaction of a major intracellular vitamin B12 form, cob(II)alamin (Cbl(II)), with hypochlorous acid/hypochlorite (HOCl/OCl-) have been carried out.	ocl-	158-162	Cbl proto-oncogene	Homo sapiens	106-109
27567143-2	2016	Cbl(II) (Co(II)) is rapidly oxidized by HOCl to predominately aquacobalamin/hydroxycobalamin (Cbl(III), Co(III)) with a second-order rate constant of 2.4x107M-1s-1 (25.0 C).	Hypochlorous Acid	40-44	Cbl proto-oncogene	Homo sapiens	0-3
27567143-2	2016	Cbl(II) (Co(II)) is rapidly oxidized by HOCl to predominately aquacobalamin/hydroxycobalamin (Cbl(III), Co(III)) with a second-order rate constant of 2.4x107M-1s-1 (25.0 C).	aquacobalamin/hydroxycobalamin	62-92	Cbl proto-oncogene	Homo sapiens	0-3
27567143-2	2016	Cbl(II) (Co(II)) is rapidly oxidized by HOCl to predominately aquacobalamin/hydroxycobalamin (Cbl(III), Co(III)) with a second-order rate constant of 2.4x107M-1s-1 (25.0 C).	aquacobalamin/hydroxycobalamin	62-92	Cbl proto-oncogene	Homo sapiens	94-97
27567143-7	2016	Finally, SDS-PAGE experiments show that HOCl-induced damage to bovine serum albumin does not occur in the presence of Cbl(II), providing support for Cbl(II) being an efficient HOCl trapping agent.	Hypochlorous Acid	40-44	Cbl proto-oncogene	Homo sapiens	149-152
27567143-7	2016	Finally, SDS-PAGE experiments show that HOCl-induced damage to bovine serum albumin does not occur in the presence of Cbl(II), providing support for Cbl(II) being an efficient HOCl trapping agent.	Hypochlorous Acid	176-180	Cbl proto-oncogene	Homo sapiens	149-152
27349184-2	2016	Inborn errors of Cbl metabolism are rare Mendelian disorders associated with hematological and neurological manifestations, and elevations of methylmalonic acid and/or homocysteine in the blood and urine.	Methylmalonic Acid	142-160	Cbl proto-oncogene	Homo sapiens	17-20
27349184-2	2016	Inborn errors of Cbl metabolism are rare Mendelian disorders associated with hematological and neurological manifestations, and elevations of methylmalonic acid and/or homocysteine in the blood and urine.	Homocysteine	168-180	Cbl proto-oncogene	Homo sapiens	17-20
27730072-13	2016	DISCUSSION: Even short-term treatment with metformin causes a decrease in serum Cbl folic acid and increase in Hcy, which leads to peripheral neuropathy in Type 2 diabetes patients.	Metformin	43-52	Cbl proto-oncogene	Homo sapiens	80-83
27730072-13	2016	DISCUSSION: Even short-term treatment with metformin causes a decrease in serum Cbl folic acid and increase in Hcy, which leads to peripheral neuropathy in Type 2 diabetes patients.	Folic Acid	84-94	Cbl proto-oncogene	Homo sapiens	80-83
27261451-6	2016	We report that serine-to-tyrosine mutation leads to increased tyrosine phosphorylation of S1045Y-CFTR, followed by recruitment and binding of E3-ubiquitin ligase c-cbl, resulting in enhanced ubiquitination and passage of S1045Y-CFTR in the endosome/lysosome degradative compartments.	Serine	15-21	Cbl proto-oncogene	Homo sapiens	162-167
27261451-6	2016	We report that serine-to-tyrosine mutation leads to increased tyrosine phosphorylation of S1045Y-CFTR, followed by recruitment and binding of E3-ubiquitin ligase c-cbl, resulting in enhanced ubiquitination and passage of S1045Y-CFTR in the endosome/lysosome degradative compartments.	Tyrosine	25-33	Cbl proto-oncogene	Homo sapiens	162-167
27261451-6	2016	We report that serine-to-tyrosine mutation leads to increased tyrosine phosphorylation of S1045Y-CFTR, followed by recruitment and binding of E3-ubiquitin ligase c-cbl, resulting in enhanced ubiquitination and passage of S1045Y-CFTR in the endosome/lysosome degradative compartments.	Tyrosine	62-70	Cbl proto-oncogene	Homo sapiens	162-167
27730072-2	2016	AIM: The aim of this study is to define the prevalence of Vitamin B12 deficiency in early Type 2 diabetic patients (duration &lt;=5 years or drug treatment &lt;=3 years) and the relationship among metformin exposure and levels of cobalamin (Cbl), folic acid, and homocysteine (Hcy) with severity of peripheral neuropathy.	Vitamin B 12	58-69	Cbl proto-oncogene	Homo sapiens	241-244
26950611-1	2016	Experiments were conducted to investigate the reductive dechlorination of tetrachloroethylene (PCE) by nano-Mackinawite (nFeS) with cyano-cobalamin (Cbl(III)) in cement slurries.	Tetrachloroethylene	95-98	Cbl proto-oncogene	Homo sapiens	149-152
26950611-1	2016	Experiments were conducted to investigate the reductive dechlorination of tetrachloroethylene (PCE) by nano-Mackinawite (nFeS) with cyano-cobalamin (Cbl(III)) in cement slurries.	nfes	121-125	Cbl proto-oncogene	Homo sapiens	149-152
26950611-1	2016	Experiments were conducted to investigate the reductive dechlorination of tetrachloroethylene (PCE) by nano-Mackinawite (nFeS) with cyano-cobalamin (Cbl(III)) in cement slurries.	Vitamin B 12	132-147	Cbl proto-oncogene	Homo sapiens	149-152
26950611-3	2016	PCE was finally transformed to non-chlorinated organic compounds such as ethylene, acetylene, and C3-C4 hydrocarbons by nFeS-Cbl(III) in cement slurries.	Tetrachloroethylene	0-3	Cbl proto-oncogene	Homo sapiens	125-128
26950611-3	2016	PCE was finally transformed to non-chlorinated organic compounds such as ethylene, acetylene, and C3-C4 hydrocarbons by nFeS-Cbl(III) in cement slurries.	ethylene	73-81	Cbl proto-oncogene	Homo sapiens	125-128
26950611-3	2016	PCE was finally transformed to non-chlorinated organic compounds such as ethylene, acetylene, and C3-C4 hydrocarbons by nFeS-Cbl(III) in cement slurries.	Acetylene	83-92	Cbl proto-oncogene	Homo sapiens	125-128
26950611-3	2016	PCE was finally transformed to non-chlorinated organic compounds such as ethylene, acetylene, and C3-C4 hydrocarbons by nFeS-Cbl(III) in cement slurries.	c3-c4 hydrocarbons	98-116	Cbl proto-oncogene	Homo sapiens	125-128
26950611-4	2016	X-ray photoelectron spectroscopy and PCE degradation by cement components (SiO2, Al2O3, and CaO) revealed that both the reduced Co species in Cbl(III) and the presence of Ca in cement played an important role for the enhanced reductive dechlorination of PCE.	Cobalt	128-130	Cbl proto-oncogene	Homo sapiens	142-145
26950611-5	2016	The increase in the concentration of Cbl(III) (0.005-0.1 mM), cement ratio (0.05-0.2), and suspension pH (11.5-13.5) accelerated the PCE degradation kinetics by providing more favorable environments for the production of reactive Ca species and reduction of Co species.	reactive	221-229	Cbl proto-oncogene	Homo sapiens	37-40
26950611-5	2016	The increase in the concentration of Cbl(III) (0.005-0.1 mM), cement ratio (0.05-0.2), and suspension pH (11.5-13.5) accelerated the PCE degradation kinetics by providing more favorable environments for the production of reactive Ca species and reduction of Co species.	ca species	230-240	Cbl proto-oncogene	Homo sapiens	37-40
26950611-6	2016	We also observed that the degradation efficiency of PCE by nFeS-Cbl(III)-cement lasted even at high concentration of PCE.	Tetrachloroethylene	52-55	Cbl proto-oncogene	Homo sapiens	64-67
26950611-6	2016	We also observed that the degradation efficiency of PCE by nFeS-Cbl(III)-cement lasted even at high concentration of PCE.	Tetrachloroethylene	117-120	Cbl proto-oncogene	Homo sapiens	64-67
27446930-1	2016	Vitamin B12 (cobalamin, Cbl, B12) is an indispensable water-soluble micronutrient that serves as a coenzyme for cytosolic methionine synthase (MS) and mitochondrial methylmalonyl-CoA mutase (MCM).	Water	54-59	Cbl proto-oncogene	Homo sapiens	24-27
27446930-2	2016	Deficiency of Cbl, whether nutritional or due to inborn errors of Cbl metabolism, inactivate MS and MCM leading to the accumulation of homocysteine (Hcy) and methylmalonic acid (MMA), respectively.	Homocysteine	135-147	Cbl proto-oncogene	Homo sapiens	14-17
27446930-2	2016	Deficiency of Cbl, whether nutritional or due to inborn errors of Cbl metabolism, inactivate MS and MCM leading to the accumulation of homocysteine (Hcy) and methylmalonic acid (MMA), respectively.	Homocysteine	149-152	Cbl proto-oncogene	Homo sapiens	14-17
27446930-2	2016	Deficiency of Cbl, whether nutritional or due to inborn errors of Cbl metabolism, inactivate MS and MCM leading to the accumulation of homocysteine (Hcy) and methylmalonic acid (MMA), respectively.	Methylmalonic Acid	158-176	Cbl proto-oncogene	Homo sapiens	14-17
27446930-2	2016	Deficiency of Cbl, whether nutritional or due to inborn errors of Cbl metabolism, inactivate MS and MCM leading to the accumulation of homocysteine (Hcy) and methylmalonic acid (MMA), respectively.	Methylmalonic Acid	178-181	Cbl proto-oncogene	Homo sapiens	14-17
30155026-6	2016	Partial deprotonation of the imidazole moiety through hydrogen bonding interactions was then achieved by immobilizing the biomimetic model on hydrophobic C18 silica, which yielded an unprecedented insight on how this class of Cbl-dependent proteins may fine-tune their properties in biological systems.	imidazole	29-38	Cbl proto-oncogene	Homo sapiens	226-229
30155026-6	2016	Partial deprotonation of the imidazole moiety through hydrogen bonding interactions was then achieved by immobilizing the biomimetic model on hydrophobic C18 silica, which yielded an unprecedented insight on how this class of Cbl-dependent proteins may fine-tune their properties in biological systems.	Hydrogen	54-62	Cbl proto-oncogene	Homo sapiens	226-229
30155026-6	2016	Partial deprotonation of the imidazole moiety through hydrogen bonding interactions was then achieved by immobilizing the biomimetic model on hydrophobic C18 silica, which yielded an unprecedented insight on how this class of Cbl-dependent proteins may fine-tune their properties in biological systems.	1-octadecene	154-157	Cbl proto-oncogene	Homo sapiens	226-229
30155026-6	2016	Partial deprotonation of the imidazole moiety through hydrogen bonding interactions was then achieved by immobilizing the biomimetic model on hydrophobic C18 silica, which yielded an unprecedented insight on how this class of Cbl-dependent proteins may fine-tune their properties in biological systems.	Silicon Dioxide	158-164	Cbl proto-oncogene	Homo sapiens	226-229
26724465-1	2016	BACKGROUND: Elevated plasma vitamin B12 levels (cobalamin, Cbl) are associated with increased short-term cancer risk among patients referred for this laboratory measurement.	Vitamin B 12	28-39	Cbl proto-oncogene	Homo sapiens	59-62
27048651-7	2016	Depletion of c-Cbl and Cbl-b led to an increased ligand-induced tyrosine phosphorylation of the receptor.	Tyrosine	64-72	Cbl proto-oncogene	Homo sapiens	13-18
26964637-6	2016	Moreover, we found that CQ decreased the expression of Cbl, an E3 ligase of DR5, and knock-down of Cbl markedly enhanced DR5 up-regulation.	Chloroquine	24-26	Cbl proto-oncogene	Homo sapiens	55-58
26781991-0	2016	NADPH Oxidase 1 Activity and ROS Generation Are Regulated by Grb2/Cbl-Mediated Proteasomal Degradation of NoxO1 in Colon Cancer Cells.	Reactive Oxygen Species	29-32	Cbl proto-oncogene	Homo sapiens	66-69
26781991-4	2016	We found that through the interaction between NoxO1 and growth receptor-bound protein 2 (Grb2), the Casitas B-lineage lymphoma (Cbl) E3 ligase was recruited, leading to decreased NoxO1 stability and a subsequent reduction in ROS generation upon epidermal growth factor (EGF) stimulation.	Reactive Oxygen Species	225-228	Cbl proto-oncogene	Homo sapiens	100-126
26781991-4	2016	We found that through the interaction between NoxO1 and growth receptor-bound protein 2 (Grb2), the Casitas B-lineage lymphoma (Cbl) E3 ligase was recruited, leading to decreased NoxO1 stability and a subsequent reduction in ROS generation upon epidermal growth factor (EGF) stimulation.	Reactive Oxygen Species	225-228	Cbl proto-oncogene	Homo sapiens	128-131
26781991-9	2016	Taken together, these results support a model whereby Nox1 activity and ROS generation are regulated by Grb2/Cbl-mediated proteolysis of NoxO1 in response to EGF, providing new insight into the processes by which excessive ROS production may promote oncogenic signaling to drive colorectal tumorigenesis.	Reactive Oxygen Species	72-75	Cbl proto-oncogene	Homo sapiens	109-112
26781991-9	2016	Taken together, these results support a model whereby Nox1 activity and ROS generation are regulated by Grb2/Cbl-mediated proteolysis of NoxO1 in response to EGF, providing new insight into the processes by which excessive ROS production may promote oncogenic signaling to drive colorectal tumorigenesis.	Reactive Oxygen Species	223-226	Cbl proto-oncogene	Homo sapiens	109-112
26689403-8	2016	Patients with cobalamin-nonresponsive MMA (MMA-Cbl(-)) and GA1 identified by NBS were less likely to have movement disorders than those diagnosed by selective screening (MMA-Cbl(-): 10 % versus 39 %, p = 0.002; GA1: 26 % versus 73 %, p &lt; 0.001).	Vitamin B 12	14-23	Cbl proto-oncogene	Homo sapiens	47-50
26689403-8	2016	Patients with cobalamin-nonresponsive MMA (MMA-Cbl(-)) and GA1 identified by NBS were less likely to have movement disorders than those diagnosed by selective screening (MMA-Cbl(-): 10 % versus 39 %, p = 0.002; GA1: 26 % versus 73 %, p &lt; 0.001).	Vitamin B 12	14-23	Cbl proto-oncogene	Homo sapiens	174-177
26848865-9	2016	Moreover, we showed that during cell spreading phosphorylated CD93 recruited the signaling protein Cbl, which in turn was phosphorylated on tyrosine 774.	Tyrosine	140-148	Cbl proto-oncogene	Homo sapiens	99-102
26795150-4	2016	To identify downstream signaling components of ROS during BR-mediated plant development, we searched for genes whose expression remained unchanged by ROS only in BR- signaling mutants and found calcineurin B-like (CBL) 10, which encodes a CBL should be changed to CBL10.	Reactive Oxygen Species	47-50	Cbl proto-oncogene	Homo sapiens	239-242
26139029-8	2016	In reviewing recent advances in our understanding of the coding and decoding of calcium signals, we highlight established and emerging roles of calcium signalling in coordinating membrane transport among multiple subcellular locations and distinct transport systems in plants, drawing examples from the CBL-CIPK signalling network.	Calcium	80-87	Cbl proto-oncogene	Homo sapiens	303-306
26139029-8	2016	In reviewing recent advances in our understanding of the coding and decoding of calcium signals, we highlight established and emerging roles of calcium signalling in coordinating membrane transport among multiple subcellular locations and distinct transport systems in plants, drawing examples from the CBL-CIPK signalling network.	Calcium	144-151	Cbl proto-oncogene	Homo sapiens	303-306
26795150-4	2016	To identify downstream signaling components of ROS during BR-mediated plant development, we searched for genes whose expression remained unchanged by ROS only in BR- signaling mutants and found calcineurin B-like (CBL) 10, which encodes a CBL should be changed to CBL10.	Reactive Oxygen Species	47-50	Cbl proto-oncogene	Homo sapiens	214-217
26799654-2	2016	Vitamin B12 (cobalamin, Cbl) exists in multiple forms, including methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl), serving as cofactors for MS and methylmalonylCoA mutase, respectively.	Vitamin B 12	0-11	Cbl proto-oncogene	Homo sapiens	24-27
26799654-4	2016	Total Cbl was significantly lower in older control subjects (&gt; 60 yrs of age), primarily reflecting a &gt;10-fold age-dependent decline in the level of MeCbl.	mecobalamin	155-160	Cbl proto-oncogene	Homo sapiens	6-9
26618754-3	2016	Kinetic and mechanistic studies have been carried out on the reaction between the vitamin B12-derived radical complex cob(II)alamin (Cbl(II) , Cbl(II)) with the widely used HNO donor Piloty"s acid (PA).	Vitamin B 12	82-93	Cbl proto-oncogene	Homo sapiens	133-136
26618754-3	2016	Kinetic and mechanistic studies have been carried out on the reaction between the vitamin B12-derived radical complex cob(II)alamin (Cbl(II) , Cbl(II)) with the widely used HNO donor Piloty"s acid (PA).	Vitamin B 12	82-93	Cbl proto-oncogene	Homo sapiens	143-146
26618754-4	2016	A stoichiometry of 1 : 2 Cbl(II) : PA was obtained and PA decomposition to HNO and benzenesulfinate (C6H5SO2(-)) is the rate-determining step.	Piloty's acid	35-37	Cbl proto-oncogene	Homo sapiens	25-28
26618754-4	2016	A stoichiometry of 1 : 2 Cbl(II) : PA was obtained and PA decomposition to HNO and benzenesulfinate (C6H5SO2(-)) is the rate-determining step.	Piloty's acid	55-57	Cbl proto-oncogene	Homo sapiens	25-28
26618754-4	2016	A stoichiometry of 1 : 2 Cbl(II) : PA was obtained and PA decomposition to HNO and benzenesulfinate (C6H5SO2(-)) is the rate-determining step.	nitroxyl	75-78	Cbl proto-oncogene	Homo sapiens	25-28
26618754-4	2016	A stoichiometry of 1 : 2 Cbl(II) : PA was obtained and PA decomposition to HNO and benzenesulfinate (C6H5SO2(-)) is the rate-determining step.	benzenesulfinate	83-99	Cbl proto-oncogene	Homo sapiens	25-28
26246372-1	2015	The interaction with nitric oxide (NO) is an important aspect of the biological activity of vitamin B12 (Cbl).	Nitric Oxide	21-33	Cbl proto-oncogene	Homo sapiens	105-108
26483544-1	2015	Conversion of vitamin B12 (cobalamin, Cbl) into the cofactor forms methyl-Cbl (MeCbl) and adenosyl-Cbl (AdoCbl) is required for the function of two crucial enzymes, mitochondrial methylmalonyl-CoA mutase and cytosolic methionine synthase, respectively.	Vitamin B 12	14-25	Cbl proto-oncogene	Homo sapiens	38-41
26483544-1	2015	Conversion of vitamin B12 (cobalamin, Cbl) into the cofactor forms methyl-Cbl (MeCbl) and adenosyl-Cbl (AdoCbl) is required for the function of two crucial enzymes, mitochondrial methylmalonyl-CoA mutase and cytosolic methionine synthase, respectively.	Vitamin B 12	14-25	Cbl proto-oncogene	Homo sapiens	74-77
26483544-1	2015	Conversion of vitamin B12 (cobalamin, Cbl) into the cofactor forms methyl-Cbl (MeCbl) and adenosyl-Cbl (AdoCbl) is required for the function of two crucial enzymes, mitochondrial methylmalonyl-CoA mutase and cytosolic methionine synthase, respectively.	Vitamin B 12	14-25	Cbl proto-oncogene	Homo sapiens	74-77
26483544-1	2015	Conversion of vitamin B12 (cobalamin, Cbl) into the cofactor forms methyl-Cbl (MeCbl) and adenosyl-Cbl (AdoCbl) is required for the function of two crucial enzymes, mitochondrial methylmalonyl-CoA mutase and cytosolic methionine synthase, respectively.	Vitamin B 12	27-36	Cbl proto-oncogene	Homo sapiens	74-77
26483544-1	2015	Conversion of vitamin B12 (cobalamin, Cbl) into the cofactor forms methyl-Cbl (MeCbl) and adenosyl-Cbl (AdoCbl) is required for the function of two crucial enzymes, mitochondrial methylmalonyl-CoA mutase and cytosolic methionine synthase, respectively.	Vitamin B 12	27-36	Cbl proto-oncogene	Homo sapiens	74-77
26483544-1	2015	Conversion of vitamin B12 (cobalamin, Cbl) into the cofactor forms methyl-Cbl (MeCbl) and adenosyl-Cbl (AdoCbl) is required for the function of two crucial enzymes, mitochondrial methylmalonyl-CoA mutase and cytosolic methionine synthase, respectively.	MeCbl	79-84	Cbl proto-oncogene	Homo sapiens	38-41
26483544-1	2015	Conversion of vitamin B12 (cobalamin, Cbl) into the cofactor forms methyl-Cbl (MeCbl) and adenosyl-Cbl (AdoCbl) is required for the function of two crucial enzymes, mitochondrial methylmalonyl-CoA mutase and cytosolic methionine synthase, respectively.	MeCbl	79-84	Cbl proto-oncogene	Homo sapiens	74-77
26483544-1	2015	Conversion of vitamin B12 (cobalamin, Cbl) into the cofactor forms methyl-Cbl (MeCbl) and adenosyl-Cbl (AdoCbl) is required for the function of two crucial enzymes, mitochondrial methylmalonyl-CoA mutase and cytosolic methionine synthase, respectively.	MeCbl	79-84	Cbl proto-oncogene	Homo sapiens	74-77
26206089-0	2015	miR-216a rescues dexamethasone suppression of osteogenesis, promotes osteoblast differentiation and enhances bone formation, by regulating c-Cbl-mediated PI3K/AKT pathway.	Dexamethasone	17-30	Cbl proto-oncogene	Homo sapiens	139-144
26206089-10	2015	Downregulation of c-Cbl by short hairpin RNAs can mimic the promotion effects of miR-216a and significantly rescue the suppressive effects of DEX on osteogenesis.	Dexamethasone	142-145	Cbl proto-oncogene	Homo sapiens	18-23
26142735-0	2015	Temozolomide sensitizes stem-like cells of glioma spheres to TRAIL-induced apoptosis via upregulation of casitas B-lineage lymphoma (c-Cbl) protein.	Temozolomide	0-12	Cbl proto-oncogene	Homo sapiens	133-138
26142735-11	2015	Add of TMZ also upregulated the expression of the E3 ubiquitin ligase casitas B-lineage lymphoma (c-Cbl).	Temozolomide	7-10	Cbl proto-oncogene	Homo sapiens	100-103
26142735-12	2015	Moreover, overexpression of c-Cbl alone reduced c-FLIP expression, and c-Cbl knockdown both enhanced c-FLIP expression and reduced the potentiating effect of TMZ on TRAIL-induced apoptosis.	Temozolomide	158-161	Cbl proto-oncogene	Homo sapiens	71-76
26142735-13	2015	The result indicated that TMZ may overcome TRAIL resistance in GSCs by suppressing c-FLIP expression through c-Cbl-mediated ubiquitination and degradation.	Temozolomide	26-29	Cbl proto-oncogene	Homo sapiens	109-114
26609808-5	2015	Ligand-binding results in phosphorylation of the c-Cbl docking tyrosine and ubiquitination of the receptor.	Tyrosine	63-71	Cbl proto-oncogene	Homo sapiens	49-54
26363459-3	2015	TCR crosslinking leads to phosphorylation of three tyrosine residues within the cytoplasmic tail of CD5 (Y429, Y441 and Y463) leading to the recruitment of signaling molecules like PI3K, c-Cbl and RasGAP; nevertheless, the role of these residues in T cell survival has not yet been assessed.	Tyrosine	51-59	Cbl proto-oncogene	Homo sapiens	187-192
26618754-4	2016	A stoichiometry of 1 : 2 Cbl(II) : PA was obtained and PA decomposition to HNO and benzenesulfinate (C6H5SO2(-)) is the rate-determining step.	c6h5so2	101-108	Cbl proto-oncogene	Homo sapiens	25-28
26618754-7	2016	The Cbl(I)(-) intermediate is subsequently oxidized back to Cbl(II) by a second (H)NO molecule, and Cbl(II) reacts rapidly with  NO to form nitroxylcobalamin (NOCbl).	nitroxylcobalamin	140-157	Cbl proto-oncogene	Homo sapiens	4-7
26618754-7	2016	The Cbl(I)(-) intermediate is subsequently oxidized back to Cbl(II) by a second (H)NO molecule, and Cbl(II) reacts rapidly with  NO to form nitroxylcobalamin (NOCbl).	nitroxylcobalamin	140-157	Cbl proto-oncogene	Homo sapiens	60-63
26618754-7	2016	The Cbl(I)(-) intermediate is subsequently oxidized back to Cbl(II) by a second (H)NO molecule, and Cbl(II) reacts rapidly with  NO to form nitroxylcobalamin (NOCbl).	nitroxylcobalamin	140-157	Cbl proto-oncogene	Homo sapiens	60-63
26618754-7	2016	The Cbl(I)(-) intermediate is subsequently oxidized back to Cbl(II) by a second (H)NO molecule, and Cbl(II) reacts rapidly with  NO to form nitroxylcobalamin (NOCbl).	nocbl	159-164	Cbl proto-oncogene	Homo sapiens	4-7
26618754-8	2016	Separate studies on the reaction between Cbl(I)(-) and PA shows that this system involves an additional step in which Cbl(I)(-) is first oxidized by (H)NO to Cbl(II), which reacts further with (H)NO to form NOCbl, with an overall stoichiometry of 1 : 3 Cbl(I)(-) : PA.	Piloty's acid	55-57	Cbl proto-oncogene	Homo sapiens	41-44
26618754-8	2016	Separate studies on the reaction between Cbl(I)(-) and PA shows that this system involves an additional step in which Cbl(I)(-) is first oxidized by (H)NO to Cbl(II), which reacts further with (H)NO to form NOCbl, with an overall stoichiometry of 1 : 3 Cbl(I)(-) : PA.	Piloty's acid	55-57	Cbl proto-oncogene	Homo sapiens	118-121
26618754-8	2016	Separate studies on the reaction between Cbl(I)(-) and PA shows that this system involves an additional step in which Cbl(I)(-) is first oxidized by (H)NO to Cbl(II), which reacts further with (H)NO to form NOCbl, with an overall stoichiometry of 1 : 3 Cbl(I)(-) : PA.	Piloty's acid	55-57	Cbl proto-oncogene	Homo sapiens	118-121
26618754-8	2016	Separate studies on the reaction between Cbl(I)(-) and PA shows that this system involves an additional step in which Cbl(I)(-) is first oxidized by (H)NO to Cbl(II), which reacts further with (H)NO to form NOCbl, with an overall stoichiometry of 1 : 3 Cbl(I)(-) : PA.	Piloty's acid	55-57	Cbl proto-oncogene	Homo sapiens	118-121
26618754-8	2016	Separate studies on the reaction between Cbl(I)(-) and PA shows that this system involves an additional step in which Cbl(I)(-) is first oxidized by (H)NO to Cbl(II), which reacts further with (H)NO to form NOCbl, with an overall stoichiometry of 1 : 3 Cbl(I)(-) : PA.	nocbl	207-212	Cbl proto-oncogene	Homo sapiens	41-44
26618754-8	2016	Separate studies on the reaction between Cbl(I)(-) and PA shows that this system involves an additional step in which Cbl(I)(-) is first oxidized by (H)NO to Cbl(II), which reacts further with (H)NO to form NOCbl, with an overall stoichiometry of 1 : 3 Cbl(I)(-) : PA.	nocbl	207-212	Cbl proto-oncogene	Homo sapiens	118-121
26618754-8	2016	Separate studies on the reaction between Cbl(I)(-) and PA shows that this system involves an additional step in which Cbl(I)(-) is first oxidized by (H)NO to Cbl(II), which reacts further with (H)NO to form NOCbl, with an overall stoichiometry of 1 : 3 Cbl(I)(-) : PA.	nocbl	207-212	Cbl proto-oncogene	Homo sapiens	118-121
26618754-8	2016	Separate studies on the reaction between Cbl(I)(-) and PA shows that this system involves an additional step in which Cbl(I)(-) is first oxidized by (H)NO to Cbl(II), which reacts further with (H)NO to form NOCbl, with an overall stoichiometry of 1 : 3 Cbl(I)(-) : PA.	nocbl	207-212	Cbl proto-oncogene	Homo sapiens	118-121
26618754-8	2016	Separate studies on the reaction between Cbl(I)(-) and PA shows that this system involves an additional step in which Cbl(I)(-) is first oxidized by (H)NO to Cbl(II), which reacts further with (H)NO to form NOCbl, with an overall stoichiometry of 1 : 3 Cbl(I)(-) : PA.	Piloty's acid	265-267	Cbl proto-oncogene	Homo sapiens	41-44
26618754-8	2016	Separate studies on the reaction between Cbl(I)(-) and PA shows that this system involves an additional step in which Cbl(I)(-) is first oxidized by (H)NO to Cbl(II), which reacts further with (H)NO to form NOCbl, with an overall stoichiometry of 1 : 3 Cbl(I)(-) : PA.	Piloty's acid	265-267	Cbl proto-oncogene	Homo sapiens	118-121
26618754-8	2016	Separate studies on the reaction between Cbl(I)(-) and PA shows that this system involves an additional step in which Cbl(I)(-) is first oxidized by (H)NO to Cbl(II), which reacts further with (H)NO to form NOCbl, with an overall stoichiometry of 1 : 3 Cbl(I)(-) : PA.	Piloty's acid	265-267	Cbl proto-oncogene	Homo sapiens	118-121
26618754-8	2016	Separate studies on the reaction between Cbl(I)(-) and PA shows that this system involves an additional step in which Cbl(I)(-) is first oxidized by (H)NO to Cbl(II), which reacts further with (H)NO to form NOCbl, with an overall stoichiometry of 1 : 3 Cbl(I)(-) : PA.	Piloty's acid	265-267	Cbl proto-oncogene	Homo sapiens	118-121
26618754-9	2016	Experiments in the presence of nitrite for both systems support the involvement of a Cbl(I)(-) intermediate in the Cbl(II)/PA reaction.	Nitrites	31-38	Cbl proto-oncogene	Homo sapiens	85-88
26618754-9	2016	Experiments in the presence of nitrite for both systems support the involvement of a Cbl(I)(-) intermediate in the Cbl(II)/PA reaction.	Nitrites	31-38	Cbl proto-oncogene	Homo sapiens	115-118
26618754-9	2016	Experiments in the presence of nitrite for both systems support the involvement of a Cbl(I)(-) intermediate in the Cbl(II)/PA reaction.	Piloty's acid	123-125	Cbl proto-oncogene	Homo sapiens	85-88
26618754-9	2016	Experiments in the presence of nitrite for both systems support the involvement of a Cbl(I)(-) intermediate in the Cbl(II)/PA reaction.	Piloty's acid	123-125	Cbl proto-oncogene	Homo sapiens	115-118
26104663-8	2015	Sequence analysis showed the mutation in LDD731 caused a histidine-to-tyrosine substitution of the amino acid codon 382 within the RING finger domain of c-Cbl.	Histidine	57-66	Cbl proto-oncogene	Homo sapiens	153-158
26104663-8	2015	Sequence analysis showed the mutation in LDD731 caused a histidine-to-tyrosine substitution of the amino acid codon 382 within the RING finger domain of c-Cbl.	Tyrosine	70-78	Cbl proto-oncogene	Homo sapiens	153-158
25965880-0	2015	CBL controls a tyrosine kinase network involving AXL, SYK and LYN in nilotinib-resistant chronic myeloid leukaemia.	nilotinib	69-78	Cbl proto-oncogene	Homo sapiens	0-3
25965880-3	2015	Depletion of CBL in K562 cells increases AXL and LYN protein levels, promoting cell resistance to nilotinib.	nilotinib	98-107	Cbl proto-oncogene	Homo sapiens	13-16
25965880-4	2015	Conversely, forced expression of CBL in nilotinib-resistant K562 cells (K562-rn) dramatically reduces AXL and LYN expression and resensitizes K562-rn cells to nilotinib.	nilotinib	40-49	Cbl proto-oncogene	Homo sapiens	33-36
25965880-4	2015	Conversely, forced expression of CBL in nilotinib-resistant K562 cells (K562-rn) dramatically reduces AXL and LYN expression and resensitizes K562-rn cells to nilotinib.	nilotinib	159-168	Cbl proto-oncogene	Homo sapiens	33-36
25965880-8	2015	Collectively, our results demonstrate a pivotal role for CBL in the control of a tyrosine kinase network mediating resistance to nilotinib treatment in CML cells.	nilotinib	129-138	Cbl proto-oncogene	Homo sapiens	57-60
26464686-1	2015	Methylmalonic aciduria and homocystinuria, cblC type, is the most common disorder of intracellular vitamin B12 (cobalamin, cbl) metabolism, which results in impaired biosynthesis of methylcobalamin and adenosylcobalamin.	Vitamin B 12	112-121	Cbl proto-oncogene	Homo sapiens	43-46
26287494-2	2015	It was previously reported that, in patient-derived HL-60 myeloblastic leukemia cells, retinoic acid (RA)-induced differentiation is driven by a signalsome containing c-Cbl and AhR.	Tretinoin	87-100	Cbl proto-oncogene	Homo sapiens	167-172
26287494-2	2015	It was previously reported that, in patient-derived HL-60 myeloblastic leukemia cells, retinoic acid (RA)-induced differentiation is driven by a signalsome containing c-Cbl and AhR.	Tretinoin	102-104	Cbl proto-oncogene	Homo sapiens	167-172
26264748-1	2015	Ubiquitination of the epidermal growth factor receptor (EGFR) that occurs when Cbl and Grb2 bind to three phosphotyrosine residues (pY1045, pY1068 and pY1086) on the receptor displays a sharp threshold effect as a function of EGF concentration.	Phosphotyrosine	106-121	Cbl proto-oncogene	Homo sapiens	79-82
26464686-1	2015	Methylmalonic aciduria and homocystinuria, cblC type, is the most common disorder of intracellular vitamin B12 (cobalamin, cbl) metabolism, which results in impaired biosynthesis of methylcobalamin and adenosylcobalamin.	Vitamin B 12	99-110	Cbl proto-oncogene	Homo sapiens	43-46
25815461-6	2015	Additionally, shikonin inhibited PI3k/Akt activity and upregulated Cbl protein expression.	shikonin	14-22	Cbl proto-oncogene	Homo sapiens	67-70
25820384-6	2015	After internalization and lysosomal release, Cbl binds to the cytosolic chaperon MMACHC that is responsible for (i) flavin-dependent decyanation of [CN-Co(3+) Cbl to [Co(2+)]Cbl; (ii) glutathione-dependent dealkylation of MeCbl and AdoCbl to [Co(2+/1+)]Cbl; and (iii) glutathione-dependent decyanation of CNCbl or reduction of HOCbl under anaerobic conditions.	4,6-dinitro-o-cresol	116-122	Cbl proto-oncogene	Homo sapiens	45-48
25820384-6	2015	After internalization and lysosomal release, Cbl binds to the cytosolic chaperon MMACHC that is responsible for (i) flavin-dependent decyanation of [CN-Co(3+) Cbl to [Co(2+)]Cbl; (ii) glutathione-dependent dealkylation of MeCbl and AdoCbl to [Co(2+/1+)]Cbl; and (iii) glutathione-dependent decyanation of CNCbl or reduction of HOCbl under anaerobic conditions.	4,6-dinitro-o-cresol	116-122	Cbl proto-oncogene	Homo sapiens	159-162
25820384-6	2015	After internalization and lysosomal release, Cbl binds to the cytosolic chaperon MMACHC that is responsible for (i) flavin-dependent decyanation of [CN-Co(3+) Cbl to [Co(2+)]Cbl; (ii) glutathione-dependent dealkylation of MeCbl and AdoCbl to [Co(2+/1+)]Cbl; and (iii) glutathione-dependent decyanation of CNCbl or reduction of HOCbl under anaerobic conditions.	4,6-dinitro-o-cresol	116-122	Cbl proto-oncogene	Homo sapiens	159-162
25820384-6	2015	After internalization and lysosomal release, Cbl binds to the cytosolic chaperon MMACHC that is responsible for (i) flavin-dependent decyanation of [CN-Co(3+) Cbl to [Co(2+)]Cbl; (ii) glutathione-dependent dealkylation of MeCbl and AdoCbl to [Co(2+/1+)]Cbl; and (iii) glutathione-dependent decyanation of CNCbl or reduction of HOCbl under anaerobic conditions.	4,6-dinitro-o-cresol	116-122	Cbl proto-oncogene	Homo sapiens	159-162
25820384-6	2015	After internalization and lysosomal release, Cbl binds to the cytosolic chaperon MMACHC that is responsible for (i) flavin-dependent decyanation of [CN-Co(3+) Cbl to [Co(2+)]Cbl; (ii) glutathione-dependent dealkylation of MeCbl and AdoCbl to [Co(2+/1+)]Cbl; and (iii) glutathione-dependent decyanation of CNCbl or reduction of HOCbl under anaerobic conditions.	Cobalt(2+)	167-173	Cbl proto-oncogene	Homo sapiens	45-48
25820384-6	2015	After internalization and lysosomal release, Cbl binds to the cytosolic chaperon MMACHC that is responsible for (i) flavin-dependent decyanation of [CN-Co(3+) Cbl to [Co(2+)]Cbl; (ii) glutathione-dependent dealkylation of MeCbl and AdoCbl to [Co(2+/1+)]Cbl; and (iii) glutathione-dependent decyanation of CNCbl or reduction of HOCbl under anaerobic conditions.	Glutathione	184-195	Cbl proto-oncogene	Homo sapiens	45-48
25820384-6	2015	After internalization and lysosomal release, Cbl binds to the cytosolic chaperon MMACHC that is responsible for (i) flavin-dependent decyanation of [CN-Co(3+) Cbl to [Co(2+)]Cbl; (ii) glutathione-dependent dealkylation of MeCbl and AdoCbl to [Co(2+/1+)]Cbl; and (iii) glutathione-dependent decyanation of CNCbl or reduction of HOCbl under anaerobic conditions.	mecobalamin	222-227	Cbl proto-oncogene	Homo sapiens	45-48
25820384-6	2015	After internalization and lysosomal release, Cbl binds to the cytosolic chaperon MMACHC that is responsible for (i) flavin-dependent decyanation of [CN-Co(3+) Cbl to [Co(2+)]Cbl; (ii) glutathione-dependent dealkylation of MeCbl and AdoCbl to [Co(2+/1+)]Cbl; and (iii) glutathione-dependent decyanation of CNCbl or reduction of HOCbl under anaerobic conditions.	co(2+/1+)	243-252	Cbl proto-oncogene	Homo sapiens	45-48
25820384-6	2015	After internalization and lysosomal release, Cbl binds to the cytosolic chaperon MMACHC that is responsible for (i) flavin-dependent decyanation of [CN-Co(3+) Cbl to [Co(2+)]Cbl; (ii) glutathione-dependent dealkylation of MeCbl and AdoCbl to [Co(2+/1+)]Cbl; and (iii) glutathione-dependent decyanation of CNCbl or reduction of HOCbl under anaerobic conditions.	Glutathione	268-279	Cbl proto-oncogene	Homo sapiens	45-48
25820384-6	2015	After internalization and lysosomal release, Cbl binds to the cytosolic chaperon MMACHC that is responsible for (i) flavin-dependent decyanation of [CN-Co(3+) Cbl to [Co(2+)]Cbl; (ii) glutathione-dependent dealkylation of MeCbl and AdoCbl to [Co(2+/1+)]Cbl; and (iii) glutathione-dependent decyanation of CNCbl or reduction of HOCbl under anaerobic conditions.	Vitamin B 12	305-310	Cbl proto-oncogene	Homo sapiens	45-48
25820384-6	2015	After internalization and lysosomal release, Cbl binds to the cytosolic chaperon MMACHC that is responsible for (i) flavin-dependent decyanation of [CN-Co(3+) Cbl to [Co(2+)]Cbl; (ii) glutathione-dependent dealkylation of MeCbl and AdoCbl to [Co(2+/1+)]Cbl; and (iii) glutathione-dependent decyanation of CNCbl or reduction of HOCbl under anaerobic conditions.	hocbl	327-332	Cbl proto-oncogene	Homo sapiens	45-48
25820384-7	2015	MMACHC shows a broad specificity for Cbl forms and supplies the Cbl(2+) intermediate for synthesis of MeCbl and AdoCbl.	mecobalamin	102-107	Cbl proto-oncogene	Homo sapiens	37-40
25820384-7	2015	MMACHC shows a broad specificity for Cbl forms and supplies the Cbl(2+) intermediate for synthesis of MeCbl and AdoCbl.	mecobalamin	102-107	Cbl proto-oncogene	Homo sapiens	64-67
26066468-7	2015	In vitro application of thus prepared organic polymeric nanoparticles (PEG-Bio-Cou-Cbl) in the HeLa cell line shows a reduction of cell viability by up to ~5% in the case of a combined treatment of PDT and chemotherapy whereas analogous organic polymeric NPs without the chemotherapeutic drug (PEG-Bio-Cou) result in ~49% cell viability by means of PDT process only.	Polyethylene Glycols	71-74	Cbl proto-oncogene	Homo sapiens	83-86
26066468-7	2015	In vitro application of thus prepared organic polymeric nanoparticles (PEG-Bio-Cou-Cbl) in the HeLa cell line shows a reduction of cell viability by up to ~5% in the case of a combined treatment of PDT and chemotherapy whereas analogous organic polymeric NPs without the chemotherapeutic drug (PEG-Bio-Cou) result in ~49% cell viability by means of PDT process only.	bio-cou	75-82	Cbl proto-oncogene	Homo sapiens	83-86
26464686-1	2015	Methylmalonic aciduria and homocystinuria, cblC type, is the most common disorder of intracellular vitamin B12 (cobalamin, cbl) metabolism, which results in impaired biosynthesis of methylcobalamin and adenosylcobalamin.	mecobalamin	182-197	Cbl proto-oncogene	Homo sapiens	43-46
26464686-1	2015	Methylmalonic aciduria and homocystinuria, cblC type, is the most common disorder of intracellular vitamin B12 (cobalamin, cbl) metabolism, which results in impaired biosynthesis of methylcobalamin and adenosylcobalamin.	cobamamide	202-219	Cbl proto-oncogene	Homo sapiens	43-46
25737303-4	2015	Bortezomib induced internalization and degradation of c-KIT by binding c-KIT to Cbl, an E3 ubiquitin-protein ligase, and the subsequent release of Apaf-1, which was originally bound to the c-KIT-Hsp90beta-Apaf-1 complex, induced primary apoptosis in GIST-T1 cells.	Bortezomib	0-10	Cbl proto-oncogene	Homo sapiens	80-83
25140833-5	2015	In this report, we show that the E3 ubiquitin ligase, c-CBL, is overexpressed in CTCL and that its knockdown overcomes defective TCR signaling, resulting in phosphorylation of PLC-g1, calcium influx, ROS generation, upregulation of FASL, and extrinsic pathway apoptosis in CTCL cells expressing adequate FAS.	ros	200-203	Cbl proto-oncogene	Homo sapiens	54-59
25780420-7	2015	The Cbl inhibitor Ps341 reversed the SK-induced downregulation of p-ERK and apoptosis of NCI-H460 cells.	Bortezomib	18-23	Cbl proto-oncogene	Homo sapiens	4-7
25590608-1	2015	In this study, we characterize the reductive dechlorination of tetrachloroethene (PCE) by nano-sized mackinawite (nFeS) with cobalamin (Cbl(III)) at a high pH and investigate the effects of environmental factors, including the concentrations of the target contaminant, reductant, and catalyst and suspension ions on the dechlorination kinetics of PCE.	Tetrachloroethylene	63-80	Cbl proto-oncogene	Homo sapiens	136-144
25590608-1	2015	In this study, we characterize the reductive dechlorination of tetrachloroethene (PCE) by nano-sized mackinawite (nFeS) with cobalamin (Cbl(III)) at a high pH and investigate the effects of environmental factors, including the concentrations of the target contaminant, reductant, and catalyst and suspension ions on the dechlorination kinetics of PCE.	Tetrachloroethylene	82-85	Cbl proto-oncogene	Homo sapiens	136-144
25590608-1	2015	In this study, we characterize the reductive dechlorination of tetrachloroethene (PCE) by nano-sized mackinawite (nFeS) with cobalamin (Cbl(III)) at a high pH and investigate the effects of environmental factors, including the concentrations of the target contaminant, reductant, and catalyst and suspension ions on the dechlorination kinetics of PCE.	ferrous sulfide	101-112	Cbl proto-oncogene	Homo sapiens	136-144
25590608-1	2015	In this study, we characterize the reductive dechlorination of tetrachloroethene (PCE) by nano-sized mackinawite (nFeS) with cobalamin (Cbl(III)) at a high pH and investigate the effects of environmental factors, including the concentrations of the target contaminant, reductant, and catalyst and suspension ions on the dechlorination kinetics of PCE.	nfes	114-118	Cbl proto-oncogene	Homo sapiens	136-144
25590608-1	2015	In this study, we characterize the reductive dechlorination of tetrachloroethene (PCE) by nano-sized mackinawite (nFeS) with cobalamin (Cbl(III)) at a high pH and investigate the effects of environmental factors, including the concentrations of the target contaminant, reductant, and catalyst and suspension ions on the dechlorination kinetics of PCE.	Vitamin B 12	125-134	Cbl proto-oncogene	Homo sapiens	136-144
25590608-2	2015	Ninety five percent of the PCE was degraded by nFeS with Cbl(III) in 15 h. Cyclic voltammetry conducted with regard to the reductive dechlorination showed a higher redox potential of mackinawite under a high-pH condition (-1.01 V), suggesting that the oxidation state of the central cobalt ion in the cobalamin could be reduced to Cbl(I).	nfes	47-51	Cbl proto-oncogene	Homo sapiens	57-65
25590608-2	2015	Ninety five percent of the PCE was degraded by nFeS with Cbl(III) in 15 h. Cyclic voltammetry conducted with regard to the reductive dechlorination showed a higher redox potential of mackinawite under a high-pH condition (-1.01 V), suggesting that the oxidation state of the central cobalt ion in the cobalamin could be reduced to Cbl(I).	nfes	47-51	Cbl proto-oncogene	Homo sapiens	57-60
25590608-2	2015	Ninety five percent of the PCE was degraded by nFeS with Cbl(III) in 15 h. Cyclic voltammetry conducted with regard to the reductive dechlorination showed a higher redox potential of mackinawite under a high-pH condition (-1.01 V), suggesting that the oxidation state of the central cobalt ion in the cobalamin could be reduced to Cbl(I).	ferrous sulfide	183-194	Cbl proto-oncogene	Homo sapiens	57-65
25590608-2	2015	Ninety five percent of the PCE was degraded by nFeS with Cbl(III) in 15 h. Cyclic voltammetry conducted with regard to the reductive dechlorination showed a higher redox potential of mackinawite under a high-pH condition (-1.01 V), suggesting that the oxidation state of the central cobalt ion in the cobalamin could be reduced to Cbl(I).	ferrous sulfide	183-194	Cbl proto-oncogene	Homo sapiens	57-60
25590608-5	2015	As the concentration of Cbl(III) increased from 0 to 0.5 mM, the dechlorination kinetics of PCE was accelerated (0-1.4091 h(-1)) but reached a state of equilibrium from 0.5 to 1 mM.	Tetrachloroethylene	92-95	Cbl proto-oncogene	Homo sapiens	24-27
25590608-5	2015	As the concentration of Cbl(III) increased from 0 to 0.5 mM, the dechlorination kinetics of PCE was accelerated (0-1.4091 h(-1)) but reached a state of equilibrium from 0.5 to 1 mM.	Tetrachloroethylene	92-95	Cbl proto-oncogene	Homo sapiens	28-31
25140833-5	2015	In this report, we show that the E3 ubiquitin ligase, c-CBL, is overexpressed in CTCL and that its knockdown overcomes defective TCR signaling, resulting in phosphorylation of PLC-g1, calcium influx, ROS generation, upregulation of FASL, and extrinsic pathway apoptosis in CTCL cells expressing adequate FAS.	Calcium	184-191	Cbl proto-oncogene	Homo sapiens	54-59
32262232-0	2015	Coumarin-benzothiazole-chlorambucil (Cou-Benz-Cbl) conjugate: an ESIPT based pH sensitive photoresponsive drug delivery system.	coumarin	0-8	Cbl proto-oncogene	Homo sapiens	46-49
32262232-0	2015	Coumarin-benzothiazole-chlorambucil (Cou-Benz-Cbl) conjugate: an ESIPT based pH sensitive photoresponsive drug delivery system.	benzothiazole	9-22	Cbl proto-oncogene	Homo sapiens	46-49
32262232-0	2015	Coumarin-benzothiazole-chlorambucil (Cou-Benz-Cbl) conjugate: an ESIPT based pH sensitive photoresponsive drug delivery system.	Chlorambucil	23-35	Cbl proto-oncogene	Homo sapiens	46-49
32262232-1	2015	We have developed an ESIPT based drug delivery system (DDS), Cou-Benz-Cbl conjugate, by incorporating a benzothiazole group at the 8th position of the 7-hydroxy-coumarin moiety for pH sensitive fluorescence properties and photocontrolled release of the anticancer drug chlorambucil.	benzothiazole	104-117	Cbl proto-oncogene	Homo sapiens	70-73
32262232-1	2015	We have developed an ESIPT based drug delivery system (DDS), Cou-Benz-Cbl conjugate, by incorporating a benzothiazole group at the 8th position of the 7-hydroxy-coumarin moiety for pH sensitive fluorescence properties and photocontrolled release of the anticancer drug chlorambucil.	coumarin	161-169	Cbl proto-oncogene	Homo sapiens	70-73
32262232-1	2015	We have developed an ESIPT based drug delivery system (DDS), Cou-Benz-Cbl conjugate, by incorporating a benzothiazole group at the 8th position of the 7-hydroxy-coumarin moiety for pH sensitive fluorescence properties and photocontrolled release of the anticancer drug chlorambucil.	Chlorambucil	269-281	Cbl proto-oncogene	Homo sapiens	70-73
32262232-5	2015	Photolysis of the Cou-Benz-Cbl conjugate using UV light of wavelength >=365 nm resulted in the efficient release of the anticancer drug chlorambucil.	Chlorambucil	136-148	Cbl proto-oncogene	Homo sapiens	27-30
32262232-7	2015	Further, an MTT assay showed that the Cou-Benz-Cbl conjugate has a good biocompatibility and low cytotoxicity towards the MDA-MB-231 cell line, whereas upon exposure to UV light, the Cou-Benz-Cbl conjugate exhibited enhanced cytotoxicity compared to the free drug due to the effective release of the anticancer drug chlorambucil inside the cancer cell.	monooxyethylene trimethylolpropane tristearate	12-15	Cbl proto-oncogene	Homo sapiens	47-50
32262232-7	2015	Further, an MTT assay showed that the Cou-Benz-Cbl conjugate has a good biocompatibility and low cytotoxicity towards the MDA-MB-231 cell line, whereas upon exposure to UV light, the Cou-Benz-Cbl conjugate exhibited enhanced cytotoxicity compared to the free drug due to the effective release of the anticancer drug chlorambucil inside the cancer cell.	monooxyethylene trimethylolpropane tristearate	12-15	Cbl proto-oncogene	Homo sapiens	192-195
32262232-7	2015	Further, an MTT assay showed that the Cou-Benz-Cbl conjugate has a good biocompatibility and low cytotoxicity towards the MDA-MB-231 cell line, whereas upon exposure to UV light, the Cou-Benz-Cbl conjugate exhibited enhanced cytotoxicity compared to the free drug due to the effective release of the anticancer drug chlorambucil inside the cancer cell.	Chlorambucil	316-328	Cbl proto-oncogene	Homo sapiens	47-50
32262232-7	2015	Further, an MTT assay showed that the Cou-Benz-Cbl conjugate has a good biocompatibility and low cytotoxicity towards the MDA-MB-231 cell line, whereas upon exposure to UV light, the Cou-Benz-Cbl conjugate exhibited enhanced cytotoxicity compared to the free drug due to the effective release of the anticancer drug chlorambucil inside the cancer cell.	Chlorambucil	316-328	Cbl proto-oncogene	Homo sapiens	192-195
25941627-8	2015	VAF347 augments RA-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47(phox).	VAF347	0-6	Cbl proto-oncogene	Homo sapiens	61-66
25941627-8	2015	VAF347 augments RA-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47(phox).	Tretinoin	16-18	Cbl proto-oncogene	Homo sapiens	61-66
25467488-1	2015	Methylmalonic acid (MMA) and total homocysteine (tHCYS) concentrations are used to detect acquired and inborn errors of cobalamin (vitamin B12, Cbl) metabolism and to evaluate the effect of therapeutic interventions.	Methylmalonic Acid	0-18	Cbl proto-oncogene	Homo sapiens	144-147
25140833-5	2015	In this report, we show that the E3 ubiquitin ligase, c-CBL, is overexpressed in CTCL and that its knockdown overcomes defective TCR signaling, resulting in phosphorylation of PLC-g1, calcium influx, ROS generation, upregulation of FASL, and extrinsic pathway apoptosis in CTCL cells expressing adequate FAS.	ammonium ferrous sulfate	232-235	Cbl proto-oncogene	Homo sapiens	54-59
25481740-6	2015	Restoration of normal c-Cbl function also allows more effective harnessing of estrogen receptor-alpha (ERalpha)-independent activities of tamoxifen to activate the RFC pathway and target ERalpha-negative cancer cells.	Tamoxifen	138-147	Cbl proto-oncogene	Homo sapiens	22-27
25432592-1	2015	OBJECTIVE: We evaluate the capacity of arterial (ABL), peripheral venous (VBL), and capillary (CBL) blood lactate concentration to early detect the presence of severe sepsis in patients admitted to the emergency department for a septic syndrome.	Lactic Acid	106-113	Cbl proto-oncogene	Homo sapiens	95-98
25348515-14	2015	These results suggest that dysregulation of ubiquitination is a key mechanism of EGFR hyperactivation in PDAC and that low CBL may define PDAC tumors likely to respond to erlotinib treatment.	Erlotinib Hydrochloride	171-180	Cbl proto-oncogene	Homo sapiens	123-126
25348515-9	2015	CBL knockdown increased PDAC resistance to gemcitabine and 5-fluorouracil (5-FU) by upregulating pEGFR (Y1068), pERK, and pAKT.	gemcitabine	43-54	Cbl proto-oncogene	Homo sapiens	0-3
25348515-9	2015	CBL knockdown increased PDAC resistance to gemcitabine and 5-fluorouracil (5-FU) by upregulating pEGFR (Y1068), pERK, and pAKT.	Fluorouracil	59-73	Cbl proto-oncogene	Homo sapiens	0-3
25348515-9	2015	CBL knockdown increased PDAC resistance to gemcitabine and 5-fluorouracil (5-FU) by upregulating pEGFR (Y1068), pERK, and pAKT.	Fluorouracil	75-79	Cbl proto-oncogene	Homo sapiens	0-3
25348515-11	2015	Increased chemoresistance from low CBL was abrogated by the EGFR inhibitor erlotinib both in vitro and in vivo.	Erlotinib Hydrochloride	75-84	Cbl proto-oncogene	Homo sapiens	35-38
25348515-12	2015	Erlotinib+gemcitabine-treated PDAC(CBL-low) cells exhibited greater apoptosis by cleaved PARP, caspase-3, and Annexin V/PI.	Erlotinib Hydrochloride	0-9	Cbl proto-oncogene	Homo sapiens	35-38
25348515-12	2015	Erlotinib+gemcitabine-treated PDAC(CBL-low) cells exhibited greater apoptosis by cleaved PARP, caspase-3, and Annexin V/PI.	gemcitabine	10-21	Cbl proto-oncogene	Homo sapiens	35-38
25348515-12	2015	Erlotinib+gemcitabine-treated PDAC(CBL-low) cells exhibited greater apoptosis by cleaved PARP, caspase-3, and Annexin V/PI.	pdac	30-34	Cbl proto-oncogene	Homo sapiens	35-38
25117994-3	2015	Vitamin B12 (cyancobalamin, Cbl) has two active co-enzyme forms, methylcobalamin (MeCbl) and adenosylcobalamin (AdCbl).	Vitamin B 12	0-11	Cbl proto-oncogene	Homo sapiens	28-31
25117994-3	2015	Vitamin B12 (cyancobalamin, Cbl) has two active co-enzyme forms, methylcobalamin (MeCbl) and adenosylcobalamin (AdCbl).	mecobalamin	82-87	Cbl proto-oncogene	Homo sapiens	28-31
26852513-1	2015	Cobalamin C (Cbl C) disease is an inborn error of intracellular cobalamin metabolism.	Vitamin B 12	64-73	Cbl proto-oncogene	Homo sapiens	13-16
26495279-0	2015	The Calcium Sensor CBL-CIPK Is Involved in Plant"s Response to Abiotic Stresses.	Calcium	4-11	Cbl proto-oncogene	Homo sapiens	19-22
26495279-2	2015	During stress condition, CBL-CIPK complex is identified as a primary element of calcium sensor to perceive environmental signals.	Calcium	80-87	Cbl proto-oncogene	Homo sapiens	25-28
25994134-1	2015	Formylcobalamin (formyl-Cbl), a C1-unit carrying corrinoid, and propionylcobalamin (propionyl-Cbl) were synthesized for the first time, and their properties were compared with those of acetylcobalamin (acetyl-Cbl).	formylcobalamin	0-15	Cbl proto-oncogene	Homo sapiens	24-27
25994134-2	2015	Formyl-Cbl, acetyl-Cbl, and propionyl-Cbl were decomposed by a NH2OH treatment, forming formo-, aceto-, and propionohydroxamic acids, respectively, which offers a proof for the presence of "activated" acyl groups and for their structures of Co-acyl-Cbls.	Hydroxylamine	63-68	Cbl proto-oncogene	Homo sapiens	7-10
25994134-2	2015	Formyl-Cbl, acetyl-Cbl, and propionyl-Cbl were decomposed by a NH2OH treatment, forming formo-, aceto-, and propionohydroxamic acids, respectively, which offers a proof for the presence of "activated" acyl groups and for their structures of Co-acyl-Cbls.	Hydroxylamine	63-68	Cbl proto-oncogene	Homo sapiens	19-22
25994134-2	2015	Formyl-Cbl, acetyl-Cbl, and propionyl-Cbl were decomposed by a NH2OH treatment, forming formo-, aceto-, and propionohydroxamic acids, respectively, which offers a proof for the presence of "activated" acyl groups and for their structures of Co-acyl-Cbls.	Hydroxylamine	63-68	Cbl proto-oncogene	Homo sapiens	19-22
25994134-2	2015	Formyl-Cbl, acetyl-Cbl, and propionyl-Cbl were decomposed by a NH2OH treatment, forming formo-, aceto-, and propionohydroxamic acids, respectively, which offers a proof for the presence of "activated" acyl groups and for their structures of Co-acyl-Cbls.	formo-, aceto-, and propionohydroxamic acids	88-132	Cbl proto-oncogene	Homo sapiens	7-10
25994134-2	2015	Formyl-Cbl, acetyl-Cbl, and propionyl-Cbl were decomposed by a NH2OH treatment, forming formo-, aceto-, and propionohydroxamic acids, respectively, which offers a proof for the presence of "activated" acyl groups and for their structures of Co-acyl-Cbls.	formo-, aceto-, and propionohydroxamic acids	88-132	Cbl proto-oncogene	Homo sapiens	19-22
25994134-2	2015	Formyl-Cbl, acetyl-Cbl, and propionyl-Cbl were decomposed by a NH2OH treatment, forming formo-, aceto-, and propionohydroxamic acids, respectively, which offers a proof for the presence of "activated" acyl groups and for their structures of Co-acyl-Cbls.	formo-, aceto-, and propionohydroxamic acids	88-132	Cbl proto-oncogene	Homo sapiens	19-22
25994134-2	2015	Formyl-Cbl, acetyl-Cbl, and propionyl-Cbl were decomposed by a NH2OH treatment, forming formo-, aceto-, and propionohydroxamic acids, respectively, which offers a proof for the presence of "activated" acyl groups and for their structures of Co-acyl-Cbls.	Cobalt	241-243	Cbl proto-oncogene	Homo sapiens	7-10
25994134-2	2015	Formyl-Cbl, acetyl-Cbl, and propionyl-Cbl were decomposed by a NH2OH treatment, forming formo-, aceto-, and propionohydroxamic acids, respectively, which offers a proof for the presence of "activated" acyl groups and for their structures of Co-acyl-Cbls.	Cobalt	241-243	Cbl proto-oncogene	Homo sapiens	19-22
25994134-2	2015	Formyl-Cbl, acetyl-Cbl, and propionyl-Cbl were decomposed by a NH2OH treatment, forming formo-, aceto-, and propionohydroxamic acids, respectively, which offers a proof for the presence of "activated" acyl groups and for their structures of Co-acyl-Cbls.	Cobalt	241-243	Cbl proto-oncogene	Homo sapiens	19-22
25994134-2	2015	Formyl-Cbl, acetyl-Cbl, and propionyl-Cbl were decomposed by a NH2OH treatment, forming formo-, aceto-, and propionohydroxamic acids, respectively, which offers a proof for the presence of "activated" acyl groups and for their structures of Co-acyl-Cbls.	Chlorambucil	248-253	Cbl proto-oncogene	Homo sapiens	7-10
25994134-2	2015	Formyl-Cbl, acetyl-Cbl, and propionyl-Cbl were decomposed by a NH2OH treatment, forming formo-, aceto-, and propionohydroxamic acids, respectively, which offers a proof for the presence of "activated" acyl groups and for their structures of Co-acyl-Cbls.	Chlorambucil	248-253	Cbl proto-oncogene	Homo sapiens	19-22
25994134-2	2015	Formyl-Cbl, acetyl-Cbl, and propionyl-Cbl were decomposed by a NH2OH treatment, forming formo-, aceto-, and propionohydroxamic acids, respectively, which offers a proof for the presence of "activated" acyl groups and for their structures of Co-acyl-Cbls.	Chlorambucil	248-253	Cbl proto-oncogene	Homo sapiens	19-22
25994134-3	2015	These results, together with chromatographic, electrophoretic, and spectroscopic properties, indicate that the acyl-Cbls synthesized are actually formyl-Cbl, acetyl-Cbl, and propionyl-Cbl.	acyl-cbls	111-120	Cbl proto-oncogene	Homo sapiens	153-156
25994134-3	2015	These results, together with chromatographic, electrophoretic, and spectroscopic properties, indicate that the acyl-Cbls synthesized are actually formyl-Cbl, acetyl-Cbl, and propionyl-Cbl.	acyl-cbls	111-120	Cbl proto-oncogene	Homo sapiens	153-156
25994134-5	2015	All acyl-Cbls underwent the Co-C bond cleavage upon photo-irradiation with a tungsten light bulb as well as upon treatment with alkali, forming aquacobalamin (aqCbl) and hydroxocobalamin (OH-Cbl), respectively, under air.	aquacobalamin	144-157	Cbl proto-oncogene	Homo sapiens	9-12
25994134-5	2015	All acyl-Cbls underwent the Co-C bond cleavage upon photo-irradiation with a tungsten light bulb as well as upon treatment with alkali, forming aquacobalamin (aqCbl) and hydroxocobalamin (OH-Cbl), respectively, under air.	aquacobalamin	159-164	Cbl proto-oncogene	Homo sapiens	9-12
25994134-5	2015	All acyl-Cbls underwent the Co-C bond cleavage upon photo-irradiation with a tungsten light bulb as well as upon treatment with alkali, forming aquacobalamin (aqCbl) and hydroxocobalamin (OH-Cbl), respectively, under air.	Hydroxocobalamin	170-186	Cbl proto-oncogene	Homo sapiens	9-12
25994134-6	2015	Formyl-Cbl was thermally unstable and decomposed to aqCbl, and the thermal stability in neutral solution was much lower than in diluted HCl.	aquacobalamin	52-57	Cbl proto-oncogene	Homo sapiens	7-10
25994134-6	2015	Formyl-Cbl was thermally unstable and decomposed to aqCbl, and the thermal stability in neutral solution was much lower than in diluted HCl.	Hydrochloric Acid	136-139	Cbl proto-oncogene	Homo sapiens	7-10
25994134-9	2015	Such abnormal behaviors of formyl-Cbl suggest that it mainly exists in a hydrated form as formaldehyde.	Formaldehyde	90-102	Cbl proto-oncogene	Homo sapiens	34-37
25049238-5	2014	More importantly, a glycan array screening revealed that single-point mutations in the CBL2 could produce significant changes in the carbohydrate specificity of the protein.	Polysaccharides	20-26	Cbl proto-oncogene	Homo sapiens	87-91
25552533-1	2014	The uptake and transport of vitamin B12 (cobalamin; Cbl) in mammals involves a refined system with three evolutionarily related transporters: transcobalamin 1 (Tcn1), transcobalamin 2 (Tcn2), and the gastric intrinsic factor (Gif).	Vitamin B 12	28-39	Cbl proto-oncogene	Homo sapiens	52-55
25084697-3	2014	We found that Src was degraded mainly by the proteasomal pathway because the proteasome inhibitor MG-132 but not the lysosome inhibitor NH4Cl suppressed the EPO-induced degradation of Src in F-36P cells and that knockdown of Cbl inhibited EPO-induced ubiquitination and degradation of Src in F-36P cells.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	98-104	Cbl proto-oncogene	Homo sapiens	225-228
25084697-5	2014	In addition, the co-expression experiments and in vitro kinase assay demonstrated that the EPO-induced tyrosine phosphorylation and ubiquitination of Cbl were dependent on the kinase activity of Src but not Jak2.	Tyrosine	103-111	Cbl proto-oncogene	Homo sapiens	150-153
25084697-6	2014	Thus, Cbl negatively regulates EPO signaling mainly through the proteasome-dependent degradation of Src, and the E3 ligase activity of Cbl and its tyrosine phosphorylation are regulated by Src but not Jak2.	Tyrosine	147-155	Cbl proto-oncogene	Homo sapiens	135-138
25049238-3	2014	Based on the crystallographic structure of the N-Epa1p domain and the role of the variable loop CBL2 in glycan binding, saturation mutagenesis on some residues of the CBL2 loop was used to increase the binding affinity of N-Epa1p for fibronectin, which was selected as a model of a human glycoprotein.	Polysaccharides	104-110	Cbl proto-oncogene	Homo sapiens	167-171
25049238-3	2014	Based on the crystallographic structure of the N-Epa1p domain and the role of the variable loop CBL2 in glycan binding, saturation mutagenesis on some residues of the CBL2 loop was used to increase the binding affinity of N-Epa1p for fibronectin, which was selected as a model of a human glycoprotein.	n-epa1p	47-54	Cbl proto-oncogene	Homo sapiens	167-171
25049238-5	2014	More importantly, a glycan array screening revealed that single-point mutations in the CBL2 could produce significant changes in the carbohydrate specificity of the protein.	Carbohydrates	133-145	Cbl proto-oncogene	Homo sapiens	87-91
26088992-1	2014	For the purpose of light extraction and efficiency enhancement, the nitride-based ultraviolet vertical-injection light-emitting diodes (UV-VLEDs) with non-insulation current blocking layer (n-CBL) and optimized textured surface were fabricated.	nitride	68-75	Cbl proto-oncogene	Homo sapiens	192-195
25288725-2	2014	The family of CBL-interacting protein kinases (CIPK) and their interacting activators, the calcium sensors calcineurin B-like (CBLs), work together to decode calcium signals elicited by stress situations.	Calcium	91-98	Cbl proto-oncogene	Homo sapiens	14-17
25345916-7	2014	Simple dose-responses were found, as for the PMN proteins S100A9 (A9) and S100A8 (A8), and the system also revealed the reducing capacity of vitamin B12 (Cbl) and lutein.	Vitamin B 12	141-152	Cbl proto-oncogene	Homo sapiens	154-157
25387128-7	2014	Knock down of c-CBL, a ring finger ubiquitin ligase, in HEK293 cells increased the expression of Flt1 although it did not appear to require a previously published tyrosine residue (1333Y) in the C-terminus of Flt1.	Tyrosine	163-171	Cbl proto-oncogene	Homo sapiens	14-19
25178484-5	2014	Expression of CBL(K382E), CBL(D390Y), or CBL(R420Q) in COS-7 cells resulted in increased levels of surface EGFR and reduced amounts of intracellular EGFR; both consequences indicate ineffective EGFR internalization.	carbonyl sulfide	55-58	Cbl proto-oncogene	Homo sapiens	14-17
25288725-2	2014	The family of CBL-interacting protein kinases (CIPK) and their interacting activators, the calcium sensors calcineurin B-like (CBLs), work together to decode calcium signals elicited by stress situations.	Chlorambucil	127-131	Cbl proto-oncogene	Homo sapiens	14-17
25288725-2	2014	The family of CBL-interacting protein kinases (CIPK) and their interacting activators, the calcium sensors calcineurin B-like (CBLs), work together to decode calcium signals elicited by stress situations.	Calcium	158-165	Cbl proto-oncogene	Homo sapiens	14-17
25288725-3	2014	The molecular basis of biological activation of CIPKs relies on the calcium-dependent interaction of a self-inhibitory NAF motif with a particular CBL, the phosphorylation of the activation loop by upstream kinases, and the subsequent phosphorylation of the CBL by the CIPK.	Calcium	68-75	Cbl proto-oncogene	Homo sapiens	147-150
25288725-3	2014	The molecular basis of biological activation of CIPKs relies on the calcium-dependent interaction of a self-inhibitory NAF motif with a particular CBL, the phosphorylation of the activation loop by upstream kinases, and the subsequent phosphorylation of the CBL by the CIPK.	Calcium	68-75	Cbl proto-oncogene	Homo sapiens	258-261
25005938-0	2014	The basic amino acids in the coiled-coil domain of CIN85 regulate its interaction with c-Cbl and phosphatidic acid during epidermal growth factor receptor (EGFR) endocytosis.	Amino Acids, Basic	4-21	Cbl proto-oncogene	Homo sapiens	87-92
25205850-4	2014	We used coexpression analyses in Xenopus oocytes to show that the calcineurin B-like (CBL) calcium sensors CBL1 and CBL9 and their interacting protein kinase CIPK23 also triggered SLAC1 and SLAH3 opening.	Calcium	91-98	Cbl proto-oncogene	Homo sapiens	86-89
25205850-8	2014	These findings identified CBL/CIPK complexes as potential regulators of stomatal aperture through S-type anion channels and indicated that phosphorylation at distinct sites enables SLAC1 activation by both calcium-dependent and calcium-independent pathways downstream of ABA.	Abscisic Acid	271-274	Cbl proto-oncogene	Homo sapiens	26-29
25298785-6	2014	The breakpoint was close to the folate sensitive rare fragile site FRA11B and the aphidicolin inducible common fragile site FRA11G, the co-localization fragile site could have caused instability and constitutional chromosomal breakage.	Folic Acid	32-38	Cbl proto-oncogene	Homo sapiens	67-73
24722857-1	2014	In humans vitamin B12 (cobalamin, Cbl) must be converted into two coenzyme forms, methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl), in order to maintain intracellular homeostasis of homocysteine and methylmalonic acid, respectively.	Vitamin B 12	10-21	Cbl proto-oncogene	Homo sapiens	34-37
24722857-1	2014	In humans vitamin B12 (cobalamin, Cbl) must be converted into two coenzyme forms, methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl), in order to maintain intracellular homeostasis of homocysteine and methylmalonic acid, respectively.	mecobalamin	82-97	Cbl proto-oncogene	Homo sapiens	34-37
24722857-1	2014	In humans vitamin B12 (cobalamin, Cbl) must be converted into two coenzyme forms, methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl), in order to maintain intracellular homeostasis of homocysteine and methylmalonic acid, respectively.	mecobalamin	99-104	Cbl proto-oncogene	Homo sapiens	34-37
24722857-1	2014	In humans vitamin B12 (cobalamin, Cbl) must be converted into two coenzyme forms, methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl), in order to maintain intracellular homeostasis of homocysteine and methylmalonic acid, respectively.	cobamamide	110-127	Cbl proto-oncogene	Homo sapiens	34-37
24722857-1	2014	In humans vitamin B12 (cobalamin, Cbl) must be converted into two coenzyme forms, methylcobalamin (MeCbl) and adenosylcobalamin (AdoCbl), in order to maintain intracellular homeostasis of homocysteine and methylmalonic acid, respectively.	Methylmalonic Acid	205-223	Cbl proto-oncogene	Homo sapiens	34-37
24876153-6	2014	PTPRU knockdown also led to increased tyrosine pY of the E3 ubiquitin ligase c-Cbl and to the destabilization of several focal adhesion proteins.	Tyrosine	38-46	Cbl proto-oncogene	Homo sapiens	77-82
25005938-12	2014	The positive charges of basic amino acids in the coiled-coil domain are not only involved in the interaction with phosphatidic acid, but also regulate the interaction of CIN85 with c-Cbl.	Phosphatidic Acids	114-131	Cbl proto-oncogene	Homo sapiens	181-186
25005938-1	2014	BACKGROUND: During EGFR internalization CIN85 bridges EGFR-Cbl complex, endocytic machinery and fusible membrane through the interactions of CIN85 with c-Cbl, endophilins and phosphatidic acid.	Phosphatidic Acids	175-192	Cbl proto-oncogene	Homo sapiens	59-62
25005938-5	2014	RESULTS: Mutations of the basic amino acids in the coiled-coil domain, especially K645, K646, R648 and R650, into neutral amino acid alanine completely blocked the interaction of CIN85 with c-Cbl or phosphatidic acid.	Amino Acids, Basic	26-43	Cbl proto-oncogene	Homo sapiens	190-195
25005938-5	2014	RESULTS: Mutations of the basic amino acids in the coiled-coil domain, especially K645, K646, R648 and R650, into neutral amino acid alanine completely blocked the interaction of CIN85 with c-Cbl or phosphatidic acid.	k645	82-86	Cbl proto-oncogene	Homo sapiens	190-195
25005938-5	2014	RESULTS: Mutations of the basic amino acids in the coiled-coil domain, especially K645, K646, R648 and R650, into neutral amino acid alanine completely blocked the interaction of CIN85 with c-Cbl or phosphatidic acid.	k646	88-92	Cbl proto-oncogene	Homo sapiens	190-195
25005938-5	2014	RESULTS: Mutations of the basic amino acids in the coiled-coil domain, especially K645, K646, R648 and R650, into neutral amino acid alanine completely blocked the interaction of CIN85 with c-Cbl or phosphatidic acid.	Alanine	133-140	Cbl proto-oncogene	Homo sapiens	190-195
25005938-12	2014	The positive charges of basic amino acids in the coiled-coil domain are not only involved in the interaction with phosphatidic acid, but also regulate the interaction of CIN85 with c-Cbl.	Amino Acids, Basic	24-41	Cbl proto-oncogene	Homo sapiens	181-186
25074859-6	2014	Intrinsic water-use efficiency scaled negatively with carbon isotope discrimination (Delta13Cbl) and positively with the ratio between mesophyll diffusion conductance (gm) and stomatal conductance.	Water	10-15	Cbl proto-oncogene	Homo sapiens	92-95
24686085-8	2014	In contrast another SFK inhibitor (dasatinib) which blocks Lyn activity with ATRA co-treatment prevented ATRA-induced c-Cbl phosphorylation and crippled p85 PI3K phosphorylation, indicating Lyn kinase activity is important for ATRA-propelled events potentially regulated by CD38.	Dasatinib	35-44	Cbl proto-oncogene	Homo sapiens	118-123
24686085-8	2014	In contrast another SFK inhibitor (dasatinib) which blocks Lyn activity with ATRA co-treatment prevented ATRA-induced c-Cbl phosphorylation and crippled p85 PI3K phosphorylation, indicating Lyn kinase activity is important for ATRA-propelled events potentially regulated by CD38.	Tretinoin	77-81	Cbl proto-oncogene	Homo sapiens	118-123
24686085-8	2014	In contrast another SFK inhibitor (dasatinib) which blocks Lyn activity with ATRA co-treatment prevented ATRA-induced c-Cbl phosphorylation and crippled p85 PI3K phosphorylation, indicating Lyn kinase activity is important for ATRA-propelled events potentially regulated by CD38.	Tretinoin	105-109	Cbl proto-oncogene	Homo sapiens	118-123
24985478-3	2014	METHODS: Expression and activity of c-Cbl were blocked in immortalized human corneal epithelial cells (hTCEpi) using RNAi and pharmacological agents ([4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo-d-3,4-pyrimidine] or PP1).	4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine	151-214	Cbl proto-oncogene	Homo sapiens	36-41
24985478-6	2014	RESULTS: Knockdown and inhibition of c-Cbl decreased ligand-dependent ubiquitylation of the EGFR and prolonged receptor activity as measured by tyrosine phosphorylation.	Tyrosine	144-152	Cbl proto-oncogene	Homo sapiens	37-42
24097244-4	2014	In addition, research has shown that there is crosstalk between the CBL-CIPK pathway and the low-K+ response pathway, the ABA signaling pathway, the nitrate sensing and signaling pathway, and others.	Nitrates	149-156	Cbl proto-oncogene	Homo sapiens	68-71
24922062-5	2014	Two sequentially emergent RA-resistant HL-60 cell lines, R38+ and R38-, distinguishable by RA-inducible CD38 expression, do not arrest in G1/G0 and fail to upregulate CD11b and the myeloid-associated signaling factors Vav1, c-Cbl, Lyn, Fgr, and c-Raf after RA treatment.	Tretinoin	26-28	Cbl proto-oncogene	Homo sapiens	224-229
24886428-2	2014	It is well-known that Fcgamma receptor (FcgammaR) crosslinking induces the tyrosine phosphorylation of CBL which is associated with FcgammaR mediated phagocytosis, however how signaling molecules coordinate to desensitize these receptors is unclear.	Tyrosine	75-83	Cbl proto-oncogene	Homo sapiens	103-106
24886428-4	2014	RESULTS: Using the U937IF cell line, we observed that FcgammaR1 crosslinking induces the tyrosine phosphorylation of CBL, which is maximal at 5 min.	Tyrosine	89-97	Cbl proto-oncogene	Homo sapiens	117-120
24886428-11	2014	These findings suggest a mechanism for Fcgamma receptor desensitization by which a serine-threonine kinase e.g. PKC downregulates tyrosine phosphorylation dependent signaling events via the reduced tyrosine phosphorylation of the complex adapter protein, CBL.	Tyrosine	130-138	Cbl proto-oncogene	Homo sapiens	255-258
24886428-11	2014	These findings suggest a mechanism for Fcgamma receptor desensitization by which a serine-threonine kinase e.g. PKC downregulates tyrosine phosphorylation dependent signaling events via the reduced tyrosine phosphorylation of the complex adapter protein, CBL.	Tyrosine	198-206	Cbl proto-oncogene	Homo sapiens	255-258
24575873-4	2014	The surface morphologies and surface potential changes of the CBL-incorporated P3HT:PCBM photoactive layers were studied by atomic force microscopy and scanning Kelvin probe microscopy, respectively, suggesting the formation of an interfacial dipole layer between the photoactive layer and Al cathode, which may decrease the energy level offset between the work function of Al and the lowest unoccipoed molecular orbital level (LUMO) of the PCBM acceptor and consequently facilitate electron extraction by the Al cathode.	p3ht	79-83	Cbl proto-oncogene	Homo sapiens	62-65
24575873-4	2014	The surface morphologies and surface potential changes of the CBL-incorporated P3HT:PCBM photoactive layers were studied by atomic force microscopy and scanning Kelvin probe microscopy, respectively, suggesting the formation of an interfacial dipole layer between the photoactive layer and Al cathode, which may decrease the energy level offset between the work function of Al and the lowest unoccipoed molecular orbital level (LUMO) of the PCBM acceptor and consequently facilitate electron extraction by the Al cathode.	PCBM	84-88	Cbl proto-oncogene	Homo sapiens	62-65
24575873-4	2014	The surface morphologies and surface potential changes of the CBL-incorporated P3HT:PCBM photoactive layers were studied by atomic force microscopy and scanning Kelvin probe microscopy, respectively, suggesting the formation of an interfacial dipole layer between the photoactive layer and Al cathode, which may decrease the energy level offset between the work function of Al and the lowest unoccipoed molecular orbital level (LUMO) of the PCBM acceptor and consequently facilitate electron extraction by the Al cathode.	dipole	243-249	Cbl proto-oncogene	Homo sapiens	62-65
24575873-4	2014	The surface morphologies and surface potential changes of the CBL-incorporated P3HT:PCBM photoactive layers were studied by atomic force microscopy and scanning Kelvin probe microscopy, respectively, suggesting the formation of an interfacial dipole layer between the photoactive layer and Al cathode, which may decrease the energy level offset between the work function of Al and the lowest unoccipoed molecular orbital level (LUMO) of the PCBM acceptor and consequently facilitate electron extraction by the Al cathode.	al cathode	290-300	Cbl proto-oncogene	Homo sapiens	62-65
24575873-4	2014	The surface morphologies and surface potential changes of the CBL-incorporated P3HT:PCBM photoactive layers were studied by atomic force microscopy and scanning Kelvin probe microscopy, respectively, suggesting the formation of an interfacial dipole layer between the photoactive layer and Al cathode, which may decrease the energy level offset between the work function of Al and the lowest unoccipoed molecular orbital level (LUMO) of the PCBM acceptor and consequently facilitate electron extraction by the Al cathode.	Aluminum	290-292	Cbl proto-oncogene	Homo sapiens	62-65
24575873-4	2014	The surface morphologies and surface potential changes of the CBL-incorporated P3HT:PCBM photoactive layers were studied by atomic force microscopy and scanning Kelvin probe microscopy, respectively, suggesting the formation of an interfacial dipole layer between the photoactive layer and Al cathode, which may decrease the energy level offset between the work function of Al and the lowest unoccipoed molecular orbital level (LUMO) of the PCBM acceptor and consequently facilitate electron extraction by the Al cathode.	PCBM	441-445	Cbl proto-oncogene	Homo sapiens	62-65
24575873-4	2014	The surface morphologies and surface potential changes of the CBL-incorporated P3HT:PCBM photoactive layers were studied by atomic force microscopy and scanning Kelvin probe microscopy, respectively, suggesting the formation of an interfacial dipole layer between the photoactive layer and Al cathode, which may decrease the energy level offset between the work function of Al and the lowest unoccipoed molecular orbital level (LUMO) of the PCBM acceptor and consequently facilitate electron extraction by the Al cathode.	al cathode	510-520	Cbl proto-oncogene	Homo sapiens	62-65
24575873-6	2014	Besides, the coordination interaction between the lone-pair electrons on the N atoms of the amino (-NH2) group and the Al atoms may prohibit interaction between Al and the thiophene rings of P3HT, contributing to the efficiency enhancement of the CBL-incorporated devices as well.	Nitrogen	77-78	Cbl proto-oncogene	Homo sapiens	247-250
24575873-6	2014	Besides, the coordination interaction between the lone-pair electrons on the N atoms of the amino (-NH2) group and the Al atoms may prohibit interaction between Al and the thiophene rings of P3HT, contributing to the efficiency enhancement of the CBL-incorporated devices as well.	Aluminum	119-121	Cbl proto-oncogene	Homo sapiens	247-250
24575873-6	2014	Besides, the coordination interaction between the lone-pair electrons on the N atoms of the amino (-NH2) group and the Al atoms may prohibit interaction between Al and the thiophene rings of P3HT, contributing to the efficiency enhancement of the CBL-incorporated devices as well.	Aluminum	161-163	Cbl proto-oncogene	Homo sapiens	247-250
24575873-6	2014	Besides, the coordination interaction between the lone-pair electrons on the N atoms of the amino (-NH2) group and the Al atoms may prohibit interaction between Al and the thiophene rings of P3HT, contributing to the efficiency enhancement of the CBL-incorporated devices as well.	Thiophenes	172-181	Cbl proto-oncogene	Homo sapiens	247-250
24575873-6	2014	Besides, the coordination interaction between the lone-pair electrons on the N atoms of the amino (-NH2) group and the Al atoms may prohibit interaction between Al and the thiophene rings of P3HT, contributing to the efficiency enhancement of the CBL-incorporated devices as well.	p3ht	191-195	Cbl proto-oncogene	Homo sapiens	247-250
24575873-7	2014	In this sense, the different CBL performance of biuret, DCDA, and urea is also proposed to partially originate from the differences on their chemical structure, specifically the number of amino groups.	Biuret	48-54	Cbl proto-oncogene	Homo sapiens	29-32
24575873-7	2014	In this sense, the different CBL performance of biuret, DCDA, and urea is also proposed to partially originate from the differences on their chemical structure, specifically the number of amino groups.	dicyandiamido	56-60	Cbl proto-oncogene	Homo sapiens	29-32
24575873-7	2014	In this sense, the different CBL performance of biuret, DCDA, and urea is also proposed to partially originate from the differences on their chemical structure, specifically the number of amino groups.	Urea	66-70	Cbl proto-oncogene	Homo sapiens	29-32
24886428-0	2014	A PKC-SHP1 signaling axis desensitizes Fcgamma receptor signaling by reducing the tyrosine phosphorylation of CBL and regulates FcgammaR mediated phagocytosis.	Tyrosine	82-90	Cbl proto-oncogene	Homo sapiens	110-113
24458840-2	2014	Restoring normal c-Cbl activity by Cool-1 knockdown in vitro reduced GBM cell division, almost eliminated generation of adhesion-independent spheroids, reduced the representation of cells expressing antigens thought to identify tumor initiating cells (TICs), reduced levels of several proteins of critical importance in TIC function (such as Notch-1 and Sox2), and increased sensitivity to BCNU (carmustine) and temozolomide (TMZ).	Carmustine	390-394	Cbl proto-oncogene	Homo sapiens	17-22
24458840-2	2014	Restoring normal c-Cbl activity by Cool-1 knockdown in vitro reduced GBM cell division, almost eliminated generation of adhesion-independent spheroids, reduced the representation of cells expressing antigens thought to identify tumor initiating cells (TICs), reduced levels of several proteins of critical importance in TIC function (such as Notch-1 and Sox2), and increased sensitivity to BCNU (carmustine) and temozolomide (TMZ).	Carmustine	396-406	Cbl proto-oncogene	Homo sapiens	17-22
24458840-2	2014	Restoring normal c-Cbl activity by Cool-1 knockdown in vitro reduced GBM cell division, almost eliminated generation of adhesion-independent spheroids, reduced the representation of cells expressing antigens thought to identify tumor initiating cells (TICs), reduced levels of several proteins of critical importance in TIC function (such as Notch-1 and Sox2), and increased sensitivity to BCNU (carmustine) and temozolomide (TMZ).	Temozolomide	412-424	Cbl proto-oncogene	Homo sapiens	17-22
24458840-2	2014	Restoring normal c-Cbl activity by Cool-1 knockdown in vitro reduced GBM cell division, almost eliminated generation of adhesion-independent spheroids, reduced the representation of cells expressing antigens thought to identify tumor initiating cells (TICs), reduced levels of several proteins of critical importance in TIC function (such as Notch-1 and Sox2), and increased sensitivity to BCNU (carmustine) and temozolomide (TMZ).	Temozolomide	426-429	Cbl proto-oncogene	Homo sapiens	17-22
24718698-6	2014	Furthermore, two recent studies showed dasatinib to be effective in inhibiting the in vitro growth of cells from leukemia patients with c-Cbl RING finger and linker domain mutations.	Dasatinib	39-48	Cbl proto-oncogene	Homo sapiens	136-141
24206708-2	2014	In this study, cobalt containing compounds, namely Co(II), cyanocobalamin (CN-Cbl) and hydroxylcobalamin (OH-Cbl), were well separated by reversed phase HPLC with a C8-HPLC column as the stationary phase and 8 mmol L(-1) ammonium acetate in 22%v/v methanol solution (pH 4) as the mobile phase using isocratic elution.	Cobalt	15-21	Cbl proto-oncogene	Homo sapiens	78-81
24206708-2	2014	In this study, cobalt containing compounds, namely Co(II), cyanocobalamin (CN-Cbl) and hydroxylcobalamin (OH-Cbl), were well separated by reversed phase HPLC with a C8-HPLC column as the stationary phase and 8 mmol L(-1) ammonium acetate in 22%v/v methanol solution (pH 4) as the mobile phase using isocratic elution.	Cobalt	15-21	Cbl proto-oncogene	Homo sapiens	109-112
24206708-2	2014	In this study, cobalt containing compounds, namely Co(II), cyanocobalamin (CN-Cbl) and hydroxylcobalamin (OH-Cbl), were well separated by reversed phase HPLC with a C8-HPLC column as the stationary phase and 8 mmol L(-1) ammonium acetate in 22%v/v methanol solution (pH 4) as the mobile phase using isocratic elution.	Vitamin B 12	59-73	Cbl proto-oncogene	Homo sapiens	78-81
24206708-2	2014	In this study, cobalt containing compounds, namely Co(II), cyanocobalamin (CN-Cbl) and hydroxylcobalamin (OH-Cbl), were well separated by reversed phase HPLC with a C8-HPLC column as the stationary phase and 8 mmol L(-1) ammonium acetate in 22%v/v methanol solution (pH 4) as the mobile phase using isocratic elution.	hydroxylcobalamin	87-104	Cbl proto-oncogene	Homo sapiens	109-112
24269698-8	2014	In addition, gene silencing of c-Cbl, a negative autophagy-related regulator of c-Src, resulted in enhanced secretion of IL-1beta and IL-18 in response to trichothecene mycotoxin stimulation in human macrophages.	trichothecene mycotoxin	155-178	Cbl proto-oncogene	Homo sapiens	31-36
23924851-5	2013	OH-Cbl can be released from mAb and Fc-fusion proteins by conversion with potassium cyanide to CN-Cbl, which does not bind.	Potassium Cyanide	74-91	Cbl proto-oncogene	Homo sapiens	3-6
23208509-9	2014	In summary, we demonstrate the enhanced therapeutic potential of a novel tumor-inhibiting anti-Met antibody, SAIT301, which utilizes a Cbl-independent, LRIG1-mediated Met degradation pathway and thereby avoids the agonism that limits the effectiveness of previously reported anti-Met antibodies.	SAIT301	109-116	Cbl proto-oncogene	Homo sapiens	135-138
24457997-5	2014	This activity is independent from CBL but requires SLAP SH3 interaction with the ubiquitination factor UBE4A and SLAP SH2 interaction with pTyr594-EPHA2.	ptyr594	139-146	Cbl proto-oncogene	Homo sapiens	34-37
23924851-3	2013	Results show pink-colored product generated during manufacturing is due to association of hydroxocobalamin (OH-Cbl), a form of vitamin B12.	Hydroxocobalamin	90-106	Cbl proto-oncogene	Homo sapiens	111-114
23924851-3	2013	Results show pink-colored product generated during manufacturing is due to association of hydroxocobalamin (OH-Cbl), a form of vitamin B12.	Vitamin B 12	127-138	Cbl proto-oncogene	Homo sapiens	111-114
24457597-5	2014	Dasatinib induced ER stress which mediated EGFR degradation in a c-cbl-dependent manner.	Dasatinib	0-9	Cbl proto-oncogene	Homo sapiens	65-70
24113870-5	2013	Epo induces Cbl-dependent ubiquitination of the p85 regulatory subunit of PI3K, which binds to phosphotyrosines on EpoR.	Phosphotyrosine	95-111	Cbl proto-oncogene	Homo sapiens	12-15
24205080-9	2013	Three potential compounds, methylprotodioscin, leonuride and catalpol, have been identified that bind to Cbl (RING) domain and interfere with the Cbl (RING)-UbCH7 protein-protein interaction.	methyl protodioscin	27-45	Cbl proto-oncogene	Homo sapiens	105-108
23924851-4	2013	OH-Cbl is not part of the product manufacturing process; however we found cyanocobalamin (CN-Cbl) in cell culture media converts to OH-Cbl in the presence of light.	Vitamin B 12	74-88	Cbl proto-oncogene	Homo sapiens	3-6
23924851-4	2013	OH-Cbl is not part of the product manufacturing process; however we found cyanocobalamin (CN-Cbl) in cell culture media converts to OH-Cbl in the presence of light.	Vitamin B 12	74-88	Cbl proto-oncogene	Homo sapiens	93-96
23924851-4	2013	OH-Cbl is not part of the product manufacturing process; however we found cyanocobalamin (CN-Cbl) in cell culture media converts to OH-Cbl in the presence of light.	Vitamin B 12	74-88	Cbl proto-oncogene	Homo sapiens	93-96
24205080-9	2013	Three potential compounds, methylprotodioscin, leonuride and catalpol, have been identified that bind to Cbl (RING) domain and interfere with the Cbl (RING)-UbCH7 protein-protein interaction.	methyl protodioscin	27-45	Cbl proto-oncogene	Homo sapiens	146-149
24205080-9	2013	Three potential compounds, methylprotodioscin, leonuride and catalpol, have been identified that bind to Cbl (RING) domain and interfere with the Cbl (RING)-UbCH7 protein-protein interaction.	harpagide	47-56	Cbl proto-oncogene	Homo sapiens	105-108
24205080-9	2013	Three potential compounds, methylprotodioscin, leonuride and catalpol, have been identified that bind to Cbl (RING) domain and interfere with the Cbl (RING)-UbCH7 protein-protein interaction.	harpagide	47-56	Cbl proto-oncogene	Homo sapiens	146-149
23897813-5	2013	Reduced ubiquitylation of EGFR is accompanied by PKC-dependent increase in serine phosphorylation of c-Cbl in cells expressing elevated levels of CD82.	Serine	75-81	Cbl proto-oncogene	Homo sapiens	101-106
24010547-4	2013	On this basis, we report here the mechanism of the formation of the acyl-enzyme complex from the Henry-Michaelis complex formed by beta-lactam antibiotics and CBL.	beta-Lactams	131-142	Cbl proto-oncogene	Homo sapiens	159-162
24010547-6	2013	A general mechanism for the formation of a beta-lactam antibiotic-CBL acyl-enzyme complex is elicited, and the individual roles of the active site residues and substrate are probed.	beta-Lactams	43-54	Cbl proto-oncogene	Homo sapiens	66-69
23774213-8	2013	The Src homology 2 domain of CTEN is not only required for binding to the phosphorylated tyrosine residue at codon 774 of c-Cbl, but is also essential for the tumorigenicity observed in the presence of CTEN.	Tyrosine	89-97	Cbl proto-oncogene	Homo sapiens	122-127
24167568-9	2013	CIN85 interaction with c-Cbl was reduced by LOX-PP.	lox-pp	44-50	Cbl proto-oncogene	Homo sapiens	23-28
23027125-5	2013	Specifically, HER2 overexpression blocks epidermal growth factor receptor (EGFR) tyrosine phosphorylation on Y1045 and Y1068, the known docking sites of c-Cbl and Grb2, respectively, whereas promoting phosphorylation on Y1173, the known docking site of the Gab adaptor proteins and phospholipase C gamma.	Tyrosine	81-89	Cbl proto-oncogene	Homo sapiens	153-158
23897813-8	2013	Our data identify CD82 as a new regulator of c-Cbl, which discriminatively controls the activity of this E3 ubiquitin ligase toward heparin-binding ligand-EGFR pairs.	Heparin	132-139	Cbl proto-oncogene	Homo sapiens	45-50
23845085-5	2013	RESULTS: Cathinone, cathine and norephedrine generally reduced post-translational modifications of intracellular signal transducers in T-lymphocytes, B-lymphocytes, natural killer cells and monocytes, most prominently affecting c-Cbl (pTyr700), ERK1/2 (p-Thr202/p-Tyr204), p38 MAPK (p-Thr180/p-Tyr182) and p53 (both total p53 protein and p-Ser15).	cathinone	9-18	Cbl proto-oncogene	Homo sapiens	228-233
23754070-14	2013	We found that SAHA enhanced Tie2 protein degradation via the ubiquitin-proteasome pathway, and the expression of c-Cbl, the E3 ligase for Tie2 ubiquitination, rapidly increased after SAHA treatment.	Vorinostat	183-187	Cbl proto-oncogene	Homo sapiens	113-118
23754070-15	2013	Knockdown of c-Cbl reversed SAHA-induced Tie2 protein degradation.	Vorinostat	28-32	Cbl proto-oncogene	Homo sapiens	13-18
23845085-5	2013	RESULTS: Cathinone, cathine and norephedrine generally reduced post-translational modifications of intracellular signal transducers in T-lymphocytes, B-lymphocytes, natural killer cells and monocytes, most prominently affecting c-Cbl (pTyr700), ERK1/2 (p-Thr202/p-Tyr204), p38 MAPK (p-Thr180/p-Tyr182) and p53 (both total p53 protein and p-Ser15).	norpseudoephedrine	20-27	Cbl proto-oncogene	Homo sapiens	228-233
23845085-5	2013	RESULTS: Cathinone, cathine and norephedrine generally reduced post-translational modifications of intracellular signal transducers in T-lymphocytes, B-lymphocytes, natural killer cells and monocytes, most prominently affecting c-Cbl (pTyr700), ERK1/2 (p-Thr202/p-Tyr204), p38 MAPK (p-Thr180/p-Tyr182) and p53 (both total p53 protein and p-Ser15).	Phenylpropanolamine	32-44	Cbl proto-oncogene	Homo sapiens	228-233
23845085-5	2013	RESULTS: Cathinone, cathine and norephedrine generally reduced post-translational modifications of intracellular signal transducers in T-lymphocytes, B-lymphocytes, natural killer cells and monocytes, most prominently affecting c-Cbl (pTyr700), ERK1/2 (p-Thr202/p-Tyr204), p38 MAPK (p-Thr180/p-Tyr182) and p53 (both total p53 protein and p-Ser15).	ptyr700	235-242	Cbl proto-oncogene	Homo sapiens	228-233
23845085-10	2013	Cathinone, cathine and norephedrine reduced phosphorylation of c-Cbl, ERK1/2, p38 MAPK and p53(Ser15), and norephedrine induced T-lymphocyte proliferation.	cathinone	0-9	Cbl proto-oncogene	Homo sapiens	63-68
23845085-10	2013	Cathinone, cathine and norephedrine reduced phosphorylation of c-Cbl, ERK1/2, p38 MAPK and p53(Ser15), and norephedrine induced T-lymphocyte proliferation.	norpseudoephedrine	11-18	Cbl proto-oncogene	Homo sapiens	63-68
23845085-10	2013	Cathinone, cathine and norephedrine reduced phosphorylation of c-Cbl, ERK1/2, p38 MAPK and p53(Ser15), and norephedrine induced T-lymphocyte proliferation.	Phenylpropanolamine	23-35	Cbl proto-oncogene	Homo sapiens	63-68
23306613-0	2013	c-Cbl shRNA-expressing adenovirus sensitizes TRAIL-induced apoptosis in prostate cancer DU-145 through increases of DR4/5.	du-145	88-94	Cbl proto-oncogene	Homo sapiens	0-5
23770238-5	2013	Furthermore, we show that tTG accentuates EGFR signaling by blocking c-Cbl-catalyzed EGFR ubiquitylation through the ability of tTG to bind GTP and adopt a specific conformation that enables it to interact with c-Cbl.	Guanosine Triphosphate	140-143	Cbl proto-oncogene	Homo sapiens	69-74
23770238-5	2013	Furthermore, we show that tTG accentuates EGFR signaling by blocking c-Cbl-catalyzed EGFR ubiquitylation through the ability of tTG to bind GTP and adopt a specific conformation that enables it to interact with c-Cbl.	Guanosine Triphosphate	140-143	Cbl proto-oncogene	Homo sapiens	211-216
23665906-0	2013	The role of E3 ubiquitin ligase Cbl proteins in beta-elemene reversing multi-drug resistance of human gastric adenocarcinoma cells.	beta-elemene	48-60	Cbl proto-oncogene	Homo sapiens	32-35
23665906-3	2013	Treatment of SGC7901/ADR cells with beta-elemene led to downregulation of Akt phosphorylation and significant upregulation of the E3 ubiquitin ligases, c-Cbl and Cbl-b.	beta-elemene	36-48	Cbl proto-oncogene	Homo sapiens	152-157
23477417-1	2013	While the geometric and electronic structures of vitamin B12 (cyanocobalamin, CNCbl) and its reduced derivatives Co(2+)cobalamin (Co(2+)Cbl) and Co(1+)cobalamin (Co(1+)Cbl(-)) are now reasonably well established, their vibrational properties, in particular their resonance Raman (rR) spectra, have remained quite poorly understood.	Vitamin B 12	49-60	Cbl proto-oncogene	Homo sapiens	80-83
23477417-1	2013	While the geometric and electronic structures of vitamin B12 (cyanocobalamin, CNCbl) and its reduced derivatives Co(2+)cobalamin (Co(2+)Cbl) and Co(1+)cobalamin (Co(1+)Cbl(-)) are now reasonably well established, their vibrational properties, in particular their resonance Raman (rR) spectra, have remained quite poorly understood.	Vitamin B 12	49-60	Cbl proto-oncogene	Homo sapiens	136-139
23477417-1	2013	While the geometric and electronic structures of vitamin B12 (cyanocobalamin, CNCbl) and its reduced derivatives Co(2+)cobalamin (Co(2+)Cbl) and Co(1+)cobalamin (Co(1+)Cbl(-)) are now reasonably well established, their vibrational properties, in particular their resonance Raman (rR) spectra, have remained quite poorly understood.	co(2+)cobalamin	113-128	Cbl proto-oncogene	Homo sapiens	80-83
23477417-1	2013	While the geometric and electronic structures of vitamin B12 (cyanocobalamin, CNCbl) and its reduced derivatives Co(2+)cobalamin (Co(2+)Cbl) and Co(1+)cobalamin (Co(1+)Cbl(-)) are now reasonably well established, their vibrational properties, in particular their resonance Raman (rR) spectra, have remained quite poorly understood.	co(2+)cobalamin	113-128	Cbl proto-oncogene	Homo sapiens	136-139
23477417-6	2013	Our DFT results suggest that this variation reflects large differences in the degree of mixing between the occupied Co 3d orbitals and empty corrin pi* orbitals in CNCbl, Co(2+)Cbl, and Co(1+)Cbl(-).	corrin pi	141-150	Cbl proto-oncogene	Homo sapiens	166-169
23477417-6	2013	Our DFT results suggest that this variation reflects large differences in the degree of mixing between the occupied Co 3d orbitals and empty corrin pi* orbitals in CNCbl, Co(2+)Cbl, and Co(1+)Cbl(-).	corrin pi	141-150	Cbl proto-oncogene	Homo sapiens	177-180
23415654-1	2013	Vitamin B12 (cobalamin, cbl) is a cofactor of methionine synthase (MTR) in the synthesis of methionine, the precursor of the universal methyl donor S-Adenosylmethionine (SAM), which is involved in epigenomic regulatory mechanisms.	Vitamin B 12	0-11	Cbl proto-oncogene	Homo sapiens	24-27
23415654-1	2013	Vitamin B12 (cobalamin, cbl) is a cofactor of methionine synthase (MTR) in the synthesis of methionine, the precursor of the universal methyl donor S-Adenosylmethionine (SAM), which is involved in epigenomic regulatory mechanisms.	Vitamin B 12	13-22	Cbl proto-oncogene	Homo sapiens	24-27
23415654-1	2013	Vitamin B12 (cobalamin, cbl) is a cofactor of methionine synthase (MTR) in the synthesis of methionine, the precursor of the universal methyl donor S-Adenosylmethionine (SAM), which is involved in epigenomic regulatory mechanisms.	Methionine	46-56	Cbl proto-oncogene	Homo sapiens	24-27
23415654-1	2013	Vitamin B12 (cobalamin, cbl) is a cofactor of methionine synthase (MTR) in the synthesis of methionine, the precursor of the universal methyl donor S-Adenosylmethionine (SAM), which is involved in epigenomic regulatory mechanisms.	S-Adenosylmethionine	148-168	Cbl proto-oncogene	Homo sapiens	24-27
23606532-0	2013	Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells.	Tamoxifen	96-105	Cbl proto-oncogene	Homo sapiens	24-29
23400592-5	2013	Notably, dasatinib, an U.S. Food and Drug Administration-approved multikinase inhibitor that also targets Src family, dramatically attenuated the spontaneous and GM-CSF-induced hypersensitive growth phenotype of mononuclear cells from peripheral blood and bone marrow collected from JMML patients harboring Cbl or other known JMML-associated mutations.	Dasatinib	9-18	Cbl proto-oncogene	Homo sapiens	307-310
23241609-7	2013	Supplementation of cultured MMACHC-mutant cells with hydroxocobalamin (HOCbl) failed to restore these variants to the normal phenotype, suggesting that a defective Cbl processing pathway produces irreversible changes at the protein level.	Hydroxocobalamin	53-69	Cbl proto-oncogene	Homo sapiens	73-76
23696637-10	2013	Incubation with the JAK2 inhibitor, TG101348, abolished the increased phosphorylation of GM-CSFR betac in cells expressing CBL mutants, whereas treatment with the SRC kinase inhibitor dasatinib resulted in equalization of GM-CSFR betac phosphorylation signal between wild type CBL and CBL mutant samples.	Fedratinib	36-44	Cbl proto-oncogene	Homo sapiens	123-126
23696637-10	2013	Incubation with the JAK2 inhibitor, TG101348, abolished the increased phosphorylation of GM-CSFR betac in cells expressing CBL mutants, whereas treatment with the SRC kinase inhibitor dasatinib resulted in equalization of GM-CSFR betac phosphorylation signal between wild type CBL and CBL mutant samples.	Fedratinib	36-44	Cbl proto-oncogene	Homo sapiens	277-280
23696637-10	2013	Incubation with the JAK2 inhibitor, TG101348, abolished the increased phosphorylation of GM-CSFR betac in cells expressing CBL mutants, whereas treatment with the SRC kinase inhibitor dasatinib resulted in equalization of GM-CSFR betac phosphorylation signal between wild type CBL and CBL mutant samples.	Fedratinib	36-44	Cbl proto-oncogene	Homo sapiens	277-280
23696637-11	2013	Dasatinib treatment inhibited the elevated phosphorylation of CBL-Y371H and CBL-C384R mutants.	Dasatinib	0-9	Cbl proto-oncogene	Homo sapiens	62-65
23696637-11	2013	Dasatinib treatment inhibited the elevated phosphorylation of CBL-Y371H and CBL-C384R mutants.	Dasatinib	0-9	Cbl proto-oncogene	Homo sapiens	76-79
23548104-1	2013	A new polyfluorene derivative containing pendent alkylating chlorambucil (PFP-Cbl) was synthesized and characterized.	fluorene	6-18	Cbl proto-oncogene	Homo sapiens	78-81
23548104-1	2013	A new polyfluorene derivative containing pendent alkylating chlorambucil (PFP-Cbl) was synthesized and characterized.	Chlorambucil	60-72	Cbl proto-oncogene	Homo sapiens	78-81
23548104-6	2013	Combining the features of alkylating function, multivalent binding sites, and fluorescent characteristics, PFP-Cbl provides a new insight in the area of gene regulation and extends the new applications of conjugated polymers (CPs).	Polymers	216-224	Cbl proto-oncogene	Homo sapiens	111-114
23548104-6	2013	Combining the features of alkylating function, multivalent binding sites, and fluorescent characteristics, PFP-Cbl provides a new insight in the area of gene regulation and extends the new applications of conjugated polymers (CPs).	cps	226-229	Cbl proto-oncogene	Homo sapiens	111-114
23319802-9	2013	Moreover, knockdown of the E3 ligase Cbl (CBL) abolished PP242-induced FLIP(S) reduction.	PP242	57-62	Cbl proto-oncogene	Homo sapiens	37-40
23319802-9	2013	Moreover, knockdown of the E3 ligase Cbl (CBL) abolished PP242-induced FLIP(S) reduction.	PP242	57-62	Cbl proto-oncogene	Homo sapiens	42-45
23319802-10	2013	Thus, PP242 induces Cbl-dependent degradation of FLIP(S), leading to FLIP(S) downregulation.	PP242	6-11	Cbl proto-oncogene	Homo sapiens	20-23
23434382-11	2013	Transfection with miR-98 and miR-188-3p suppressed CBL expression.	mir-188-3p	29-39	Cbl proto-oncogene	Homo sapiens	51-54
23352614-3	2013	Tyr(700), Tyr(731), and Tyr(774) residues in the C-terminal domain of c-Cbl are major phosphorylation sites targeted by PTK6.	Tyrosine	0-3	Cbl proto-oncogene	Homo sapiens	70-75
23352614-3	2013	Tyr(700), Tyr(731), and Tyr(774) residues in the C-terminal domain of c-Cbl are major phosphorylation sites targeted by PTK6.	Tyrosine	10-13	Cbl proto-oncogene	Homo sapiens	70-75
23352614-3	2013	Tyr(700), Tyr(731), and Tyr(774) residues in the C-terminal domain of c-Cbl are major phosphorylation sites targeted by PTK6.	Tyrosine	10-13	Cbl proto-oncogene	Homo sapiens	70-75
22310290-7	2012	CBL directly binds to Smad3 through its proline-rich motif, thereby preventing Smad3 from interacting with Smad4 and blocking nuclear translocation of Smad3.	Proline	40-47	Cbl proto-oncogene	Homo sapiens	0-3
23572190-1	2013	Solving the crystal structure of Cbl(TKB) in complex with a pentapeptide, pYTPEP, revealed that the PEP region adopted a poly-L-proline type II (PPII) helix.	polyproline	121-135	Cbl proto-oncogene	Homo sapiens	33-36
23024054-8	2013	CONCLUSIONS: In CBL, strut malapposition is particularly high at the SB ostium.	Antimony	69-71	Cbl proto-oncogene	Homo sapiens	16-19
23991943-3	2013	c-Cbl is an ubiquitin ligase which requires a phosphorylated tyrosine residue at position 1045 in the cytoplasmic domain of EGFR to interact and add ubiquitin molecules.	Tyrosine	61-69	Cbl proto-oncogene	Homo sapiens	0-5
23457600-0	2013	Berberine inhibits proliferation and down-regulates epidermal growth factor receptor through activation of Cbl in colon tumor cells.	Berberine	0-9	Cbl proto-oncogene	Homo sapiens	107-110
23457600-7	2013	In this study, we also showed that berberine stimulated ubiquitin ligase Cbl activation and Cbl"s interaction with EGFR, and EGFR ubiquitinylation and down-regulation in these two cell lines in the presence or absence of EGF treatment.	Berberine	35-44	Cbl proto-oncogene	Homo sapiens	73-76
23457600-7	2013	In this study, we also showed that berberine stimulated ubiquitin ligase Cbl activation and Cbl"s interaction with EGFR, and EGFR ubiquitinylation and down-regulation in these two cell lines in the presence or absence of EGF treatment.	Berberine	35-44	Cbl proto-oncogene	Homo sapiens	92-95
23457600-8	2013	Knock-down Cbl expression blocked the effects of berberine on down-regulation of EGFR and inhibition of proliferation.	Berberine	49-58	Cbl proto-oncogene	Homo sapiens	11-14
23457600-11	2013	Taken together, these data indicate that berberine enhances Cbl activity, resulting in down-regulation of EGFR expression and inhibition of proliferation in colon tumor cells.	Berberine	41-50	Cbl proto-oncogene	Homo sapiens	60-63
22643838-3	2012	Here, using leukaemic MYL cell lines derived from CML patients, we show that TGFbeta plays a key role in imatinib-resistance via direct effects on Lyn ubiquitination and turnover that results in bursts of Lyn kinase activity, and identify c-cbl is a candidate E3 ubiquitin ligase.	Imatinib Mesylate	105-113	Cbl proto-oncogene	Homo sapiens	239-244
22770998-0	2012	Recommendations for diagnosis and management of metformin-induced vitamin B12 (Cbl) deficiency.	Metformin	48-57	Cbl proto-oncogene	Homo sapiens	79-82
22770998-1	2012	Metformin treatment is a known pharmacological cause of vitamin B12 (Cbl) deficiency with controversial responsible mechanisms.	Metformin	0-9	Cbl proto-oncogene	Homo sapiens	69-72
22542851-7	2012	Sphingomyelin clustering triggered tyrosine phosphorylation of the receptor and its accompanying proteins, Cbl and NTAL, in the absence of receptor ligands and enhanced phosphorylation of these proteins in the ligand presence.	Sphingomyelins	0-13	Cbl proto-oncogene	Homo sapiens	107-110
22542851-7	2012	Sphingomyelin clustering triggered tyrosine phosphorylation of the receptor and its accompanying proteins, Cbl and NTAL, in the absence of receptor ligands and enhanced phosphorylation of these proteins in the ligand presence.	Tyrosine	35-43	Cbl proto-oncogene	Homo sapiens	107-110
22665495-3	2012	WASp phosphorylation at tyrosine 291 results in recruitment of the E3 ligase Cbl-b, which, together with c-Cbl, carries out WASp ubiquitylation.	Tyrosine	24-32	Cbl proto-oncogene	Homo sapiens	105-110
22786724-2	2012	These signals are required to overcome inhibition mediated by the E3 ubiquitin ligase c-Cbl of the guanine nucleotide exchange factor Vav1, which promotes activation of NK cells.	Guanine	99-106	Cbl proto-oncogene	Homo sapiens	86-91
22568547-1	2012	We have studied glutathionylcobalamin (GS-Cbl) by optical spectroscopy and with density functional theory (DFT) and time-dependent DFT (TD-DFT) electronic structure methods of truncated geometric models.	glutathionylcobalamin	16-37	Cbl proto-oncogene	Homo sapiens	42-45
22568547-9	2012	Charge decomposition analysis (CDA) and extended charge decomposition analysis (ECDA), especially with BP86 shows the similar charge transfer nature of the Co-S bond in GS-Cbl and the Co-C bond in CH(3)Cbl.	Cobalt	156-160	Cbl proto-oncogene	Homo sapiens	172-175
22568547-9	2012	Charge decomposition analysis (CDA) and extended charge decomposition analysis (ECDA), especially with BP86 shows the similar charge transfer nature of the Co-S bond in GS-Cbl and the Co-C bond in CH(3)Cbl.	Cobalt	156-160	Cbl proto-oncogene	Homo sapiens	202-205
22568547-9	2012	Charge decomposition analysis (CDA) and extended charge decomposition analysis (ECDA), especially with BP86 shows the similar charge transfer nature of the Co-S bond in GS-Cbl and the Co-C bond in CH(3)Cbl.	Cobalt	156-158	Cbl proto-oncogene	Homo sapiens	172-175
22568547-9	2012	Charge decomposition analysis (CDA) and extended charge decomposition analysis (ECDA), especially with BP86 shows the similar charge transfer nature of the Co-S bond in GS-Cbl and the Co-C bond in CH(3)Cbl.	Carbon	0-1	Cbl proto-oncogene	Homo sapiens	172-175
22568547-9	2012	Charge decomposition analysis (CDA) and extended charge decomposition analysis (ECDA), especially with BP86 shows the similar charge transfer nature of the Co-S bond in GS-Cbl and the Co-C bond in CH(3)Cbl.	Carbon	0-1	Cbl proto-oncogene	Homo sapiens	202-205
22568547-12	2012	The BP86 method shows more spectral features, and the best fit was found for a GS-Cbl model with 5,6-dimethylbenzimidazole at the BP86/6-311G(d,p) level with a water cpcm solvent model.	5,6-dimethylbenzimidazole	97-122	Cbl proto-oncogene	Homo sapiens	82-85
22568547-12	2012	The BP86 method shows more spectral features, and the best fit was found for a GS-Cbl model with 5,6-dimethylbenzimidazole at the BP86/6-311G(d,p) level with a water cpcm solvent model.	Water	160-165	Cbl proto-oncogene	Homo sapiens	82-85
22787428-8	2012	Lysosome inhibitor reversed dasatinib-induced EGFR down-regulation, and c-cbl activity was increased by dasatinib, indicating that dasatinib-induced EGFR down-regulation might be through c-cbl-mediated lysosome degradation.	Dasatinib	28-37	Cbl proto-oncogene	Homo sapiens	187-192
22787428-8	2012	Lysosome inhibitor reversed dasatinib-induced EGFR down-regulation, and c-cbl activity was increased by dasatinib, indicating that dasatinib-induced EGFR down-regulation might be through c-cbl-mediated lysosome degradation.	Dasatinib	104-113	Cbl proto-oncogene	Homo sapiens	72-77
22787428-8	2012	Lysosome inhibitor reversed dasatinib-induced EGFR down-regulation, and c-cbl activity was increased by dasatinib, indicating that dasatinib-induced EGFR down-regulation might be through c-cbl-mediated lysosome degradation.	Dasatinib	104-113	Cbl proto-oncogene	Homo sapiens	187-192
22787428-8	2012	Lysosome inhibitor reversed dasatinib-induced EGFR down-regulation, and c-cbl activity was increased by dasatinib, indicating that dasatinib-induced EGFR down-regulation might be through c-cbl-mediated lysosome degradation.	Dasatinib	104-113	Cbl proto-oncogene	Homo sapiens	72-77
22787428-8	2012	Lysosome inhibitor reversed dasatinib-induced EGFR down-regulation, and c-cbl activity was increased by dasatinib, indicating that dasatinib-induced EGFR down-regulation might be through c-cbl-mediated lysosome degradation.	Dasatinib	104-113	Cbl proto-oncogene	Homo sapiens	187-192
22315494-0	2012	CBL mutations in myeloproliferative neoplasms are also found in the gene"s proline-rich domain and in patients with the V617FJAK2.	Proline	75-82	Cbl proto-oncogene	Homo sapiens	0-3
22315494-7	2012	RESULTS: An initial screening of all coding exons of CBL, CBLB and CBLC in 44 V617FJAK2-negative samples revealed two new CBL mutations (p.C416W in the RING finger domain and p.A678V in the proline-rich domain).	Proline	190-197	Cbl proto-oncogene	Homo sapiens	53-56
22467879-5	2012	Although arsenic had no effect on the abundance or activity of USP10, a deubiquitinylating enzyme, siRNA-mediated knockdown of c-Cbl, an E3 ubiquitin ligase, abolished the arsenic-stimulated degradation of CFTR.	Arsenic	172-179	Cbl proto-oncogene	Homo sapiens	127-132
22467879-6	2012	Arsenic enhanced the degradation of CFTR by increasing phosphorylated c-Cbl, which increased its interaction with CFTR, and subsequent ubiquitinylation of CFTR.	Arsenic	0-7	Cbl proto-oncogene	Homo sapiens	70-75
22262855-6	2012	Loss of Cbl protein is dependent on Met kinase activity and is partially rescued with a proteasome inhibitor, lactacystin.	lactacystin	110-121	Cbl proto-oncogene	Homo sapiens	8-11
21837364-0	2011	Cbl-regulated Akt and ERK signals are involved in beta-elemene-induced cell apoptosis in lung cancer cells.	beta-elemene	50-62	Cbl proto-oncogene	Homo sapiens	0-3
22316335-1	2012	Synthetic Co(III) complexes containing N5 donor sets undergo glutathionylation to generate biomimetic species of glutathionylcobalamin (GSCbl), an important form of cobalamin (Cbl) found in nature.	8-dehydroxythienamycin	39-41	Cbl proto-oncogene	Homo sapiens	138-141
22316335-1	2012	Synthetic Co(III) complexes containing N5 donor sets undergo glutathionylation to generate biomimetic species of glutathionylcobalamin (GSCbl), an important form of cobalamin (Cbl) found in nature.	glutathionylcobalamin	113-134	Cbl proto-oncogene	Homo sapiens	138-141
22266821-2	2012	Cbl ubiquitination activity is stimulated by phosphorylation of a linker helix region (LHR) tyrosine residue.	Tyrosine	92-100	Cbl proto-oncogene	Homo sapiens	0-3
22266821-4	2012	Structural and biochemical analyses show that CBL adopts an autoinhibited RING conformation, where the RING"s E2-binding surface associates with CBL to reduce E2 affinity.	Estradiol	110-112	Cbl proto-oncogene	Homo sapiens	46-49
22266821-4	2012	Structural and biochemical analyses show that CBL adopts an autoinhibited RING conformation, where the RING"s E2-binding surface associates with CBL to reduce E2 affinity.	Estradiol	110-112	Cbl proto-oncogene	Homo sapiens	145-148
22266821-4	2012	Structural and biochemical analyses show that CBL adopts an autoinhibited RING conformation, where the RING"s E2-binding surface associates with CBL to reduce E2 affinity.	Estradiol	159-161	Cbl proto-oncogene	Homo sapiens	46-49
22266821-4	2012	Structural and biochemical analyses show that CBL adopts an autoinhibited RING conformation, where the RING"s E2-binding surface associates with CBL to reduce E2 affinity.	Estradiol	159-161	Cbl proto-oncogene	Homo sapiens	145-148
22707875-6	2012	The reduction of Cbl(III) by dithiothreitol, which contains two thiols, is much faster even though no stable Cbl(III) complex is formed.	Dithiothreitol	29-43	Cbl proto-oncogene	Homo sapiens	17-20
22707875-4	2012	Glutathione first reacts with oxidized Cbl(III).	Glutathione	0-11	Cbl proto-oncogene	Homo sapiens	39-42
22707875-5	2012	The binding of a second glutathione required for the reduction to Cbl(II) is presumably located in the dimethyl benzimidazole ribonucleotide ligand cavity.	Glutathione	24-35	Cbl proto-oncogene	Homo sapiens	66-69
22707875-5	2012	The binding of a second glutathione required for the reduction to Cbl(II) is presumably located in the dimethyl benzimidazole ribonucleotide ligand cavity.	dimethyl benzimidazole ribonucleotide	103-140	Cbl proto-oncogene	Homo sapiens	66-69
22707875-6	2012	The reduction of Cbl(III) by dithiothreitol, which contains two thiols, is much faster even though no stable Cbl(III) complex is formed.	Dithiothreitol	29-43	Cbl proto-oncogene	Homo sapiens	109-112
22707875-6	2012	The reduction of Cbl(III) by dithiothreitol, which contains two thiols, is much faster even though no stable Cbl(III) complex is formed.	Sulfhydryl Compounds	64-70	Cbl proto-oncogene	Homo sapiens	17-20
21625213-6	2011	The shift from lysosomal degradation to recycling at the plasma membrane correlates with a reduced phosphorylation of the fibroblast growth factor receptor substrate-2alpha tyrosine 196, the major docking site for Grb2-Cbl complexes responsible for receptor ubiquitination and degradation.	Tyrosine	173-181	Cbl proto-oncogene	Homo sapiens	219-222
21837364-3	2011	The aim of the present study was to investigate how Cbl-regulated Akt and ERK affect beta-elemene-induced cell apoptosis in lung cancer cells.	beta-elemene	85-97	Cbl proto-oncogene	Homo sapiens	52-55
21837364-8	2011	These results suggest that Cbl-regulated Akt and ERK signals are involved in beta-elemene-induced cell apoptosis in lung cancer cells.	beta-elemene	77-89	Cbl proto-oncogene	Homo sapiens	27-30
21464131-9	2011	Consistent with the delayed recycling, 5-HT(2A)R resensitization was greatly attenuated in the presence of c-Cbl mutants lacking carboxyl termini, as detected by changes in the cytosolic calcium.	Calcium	187-194	Cbl proto-oncogene	Homo sapiens	107-112
21922568-3	2011	We report studies on the kinetics of the reaction between peroxynitrite/peroxynitrous acid and a major intracellular vitamin B(12) form, cob(II)alamin (Cbl(II)), using stopped-flow spectroscopy.	Peroxynitrous Acid	58-71	Cbl proto-oncogene	Homo sapiens	152-155
21922568-3	2011	We report studies on the kinetics of the reaction between peroxynitrite/peroxynitrous acid and a major intracellular vitamin B(12) form, cob(II)alamin (Cbl(II)), using stopped-flow spectroscopy.	Peroxynitrous Acid	72-90	Cbl proto-oncogene	Homo sapiens	152-155
21922568-3	2011	We report studies on the kinetics of the reaction between peroxynitrite/peroxynitrous acid and a major intracellular vitamin B(12) form, cob(II)alamin (Cbl(II)), using stopped-flow spectroscopy.	Niacinamide	117-126	Cbl proto-oncogene	Homo sapiens	152-155
21922568-4	2011	The pH dependence of the reaction is consistent with peroxynitrous acid reacting directly with Cbl(II) to give cob(III)alamin (Cbl(III)) and (.	Peroxynitrous Acid	53-71	Cbl proto-oncogene	Homo sapiens	95-98
21922568-4	2011	The pH dependence of the reaction is consistent with peroxynitrous acid reacting directly with Cbl(II) to give cob(III)alamin (Cbl(III)) and (.	Peroxynitrous Acid	53-71	Cbl proto-oncogene	Homo sapiens	127-130
21922568-4	2011	The pH dependence of the reaction is consistent with peroxynitrous acid reacting directly with Cbl(II) to give cob(III)alamin (Cbl(III)) and (.	Vitamin B 12	111-125	Cbl proto-oncogene	Homo sapiens	95-98
21922568-4	2011	The pH dependence of the reaction is consistent with peroxynitrous acid reacting directly with Cbl(II) to give cob(III)alamin (Cbl(III)) and (.	Vitamin B 12	111-125	Cbl proto-oncogene	Homo sapiens	127-130
21922568-6	2011	)NO(2) and a second molecule of Cbl(II) to primarily form nitrocobalamin.	nitritocobalamin	58-72	Cbl proto-oncogene	Homo sapiens	32-35
21922568-7	2011	In support of this mechanism, a Cbl(II)/ONOO(H) stoichiometry of 2:1 is observed at pH 7.35 and 12.0.	onoo	40-44	Cbl proto-oncogene	Homo sapiens	32-35
21922568-8	2011	The final major Cbl(III) product observed (nitrocobalamin or hydroxycobalamin) depends on the solution pH.	nitritocobalamin	43-57	Cbl proto-oncogene	Homo sapiens	16-19
21922568-8	2011	The final major Cbl(III) product observed (nitrocobalamin or hydroxycobalamin) depends on the solution pH.	Hydroxocobalamin	61-77	Cbl proto-oncogene	Homo sapiens	16-19
21922568-12	2011	Given that protein-bound Cbl is accessible to small molecules, it is likely that enzyme-bound and free intracellular Cbl(II) molecules are rapidly oxidized to inactive Cbl(III) upon exposure to peroxynitrite or (.	Peroxynitrous Acid	194-207	Cbl proto-oncogene	Homo sapiens	25-28
21922568-12	2011	Given that protein-bound Cbl is accessible to small molecules, it is likely that enzyme-bound and free intracellular Cbl(II) molecules are rapidly oxidized to inactive Cbl(III) upon exposure to peroxynitrite or (.	Peroxynitrous Acid	194-207	Cbl proto-oncogene	Homo sapiens	117-120
21922568-12	2011	Given that protein-bound Cbl is accessible to small molecules, it is likely that enzyme-bound and free intracellular Cbl(II) molecules are rapidly oxidized to inactive Cbl(III) upon exposure to peroxynitrite or (.	Peroxynitrous Acid	194-207	Cbl proto-oncogene	Homo sapiens	117-120
21830225-2	2011	The proline-arginine motif PXXXPR in c-Cbl and SH3 domains of CIN85 are essential to this interaction.	Proline	4-11	Cbl proto-oncogene	Homo sapiens	37-42
21830225-2	2011	The proline-arginine motif PXXXPR in c-Cbl and SH3 domains of CIN85 are essential to this interaction.	Arginine	12-20	Cbl proto-oncogene	Homo sapiens	37-42
21905200-4	2011	In this report, we show that TC prestimulation by the CD43 coreceptor molecule before TCR engagement inhibits TCR-dependent c-Cbl tyrosine phosphorylation, c-Cbl interaction with the adapter molecule Crk-L and promotes Cbl-b degradation in a PKCtheta-dependent manner.	Tyrosine	130-138	Cbl proto-oncogene	Homo sapiens	124-129
21768087-0	2011	c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway.	17-allylaminodemethoxygeldanamycin	32-66	Cbl proto-oncogene	Homo sapiens	0-5
21768087-5	2011	The E3 ubiquitin ligases c-Cbl and to a lesser extent Cbl-b facilitated at least partly Lys-48-linked polyubiquitination of autophosphorylated Flt3-ITD when coexpressed in 293T cells.	Lysine	88-91	Cbl proto-oncogene	Homo sapiens	25-30
21768087-6	2011	Moreover, c-Cbl and Cbl-b facilitated degradation of Flt3-ITD in 293T cells and significantly enhanced the 17-AAG-induced decline in autophosphorylated Flt3-ITD.	tanespimycin	107-113	Cbl proto-oncogene	Homo sapiens	10-15
21652039-4	2011	In the present study cob(I)alamin {Cbl(I)}, a reduced form of vitamin B(12), was used for trapping of GA.	Niacinamide	62-71	Cbl proto-oncogene	Homo sapiens	35-38
21652039-4	2011	In the present study cob(I)alamin {Cbl(I)}, a reduced form of vitamin B(12), was used for trapping of GA.	glycidamide	102-104	Cbl proto-oncogene	Homo sapiens	35-38
21652039-5	2011	Cbl(I) can react with electrophilic species, such as an epoxide, 10(5) times faster than standard nucleophiles.	Epoxy Compounds	56-63	Cbl proto-oncogene	Homo sapiens	0-3
21652039-6	2011	The trapping of GA by Cbl(I) results in the formation of an alkylcobalamin (GA-Cbl) that was used for quantitative analysis of the epoxide.	glycidamide	16-18	Cbl proto-oncogene	Homo sapiens	22-25
21652039-6	2011	The trapping of GA by Cbl(I) results in the formation of an alkylcobalamin (GA-Cbl) that was used for quantitative analysis of the epoxide.	glycidamide	16-18	Cbl proto-oncogene	Homo sapiens	79-82
21652039-6	2011	The trapping of GA by Cbl(I) results in the formation of an alkylcobalamin (GA-Cbl) that was used for quantitative analysis of the epoxide.	alkylcobalamin	60-74	Cbl proto-oncogene	Homo sapiens	22-25
21652039-6	2011	The trapping of GA by Cbl(I) results in the formation of an alkylcobalamin (GA-Cbl) that was used for quantitative analysis of the epoxide.	alkylcobalamin	60-74	Cbl proto-oncogene	Homo sapiens	79-82
21652039-6	2011	The trapping of GA by Cbl(I) results in the formation of an alkylcobalamin (GA-Cbl) that was used for quantitative analysis of the epoxide.	Epoxy Compounds	131-138	Cbl proto-oncogene	Homo sapiens	22-25
21652039-6	2011	The trapping of GA by Cbl(I) results in the formation of an alkylcobalamin (GA-Cbl) that was used for quantitative analysis of the epoxide.	Epoxy Compounds	131-138	Cbl proto-oncogene	Homo sapiens	79-82
21652039-10	2011	100 times higher than that earlier estimated by the Cbl(I) method for measurement of other (e.g. butadiene) epoxides.	3,4-epoxy-1-butene	97-116	Cbl proto-oncogene	Homo sapiens	52-55
21652039-11	2011	Compared to current analytical methods for measurement of GA, the Cbl(I) method was 10-100 times more sensitive.	glycidamide	58-60	Cbl proto-oncogene	Homo sapiens	66-69
21175263-0	2011	Ubiquitin ligase c-Cbl is involved in tamoxifen-induced apoptosis of MCF-7 cells by downregulating the survival signals.	Tamoxifen	38-47	Cbl proto-oncogene	Homo sapiens	17-22
21175263-13	2011	Over-expression of c-Cbl significantly enhanced the apoptosis-inducing effects of TAM, while 70Z/Cbl suppressed the apoptosis-inducing effects of TAM.	Tamoxifen	82-85	Cbl proto-oncogene	Homo sapiens	19-24
21175263-13	2011	Over-expression of c-Cbl significantly enhanced the apoptosis-inducing effects of TAM, while 70Z/Cbl suppressed the apoptosis-inducing effects of TAM.	Tamoxifen	82-85	Cbl proto-oncogene	Homo sapiens	21-24
21175263-14	2011	Further investigation revealed that, overexpression of c-Cbl significantly downregulated the c-Src protein levels and TAM-induced AKT activity.	Tamoxifen	118-121	Cbl proto-oncogene	Homo sapiens	55-60
21175263-15	2011	But 70Z/Cbl significantly upregulated TAM-induced ERK and AKT activity.	Tamoxifen	38-41	Cbl proto-oncogene	Homo sapiens	8-11
21248188-8	2011	After cobalamin supplementation, symptoms and laryngeal, bronchial, and cough thresholds were significantly improved in Cbl-D but not in Cbl-N patients.	Vitamin B 12	6-15	Cbl proto-oncogene	Homo sapiens	120-123
21175263-16	2011	CONCLUSIONS: This study demonstrates that c-Src, ERK, and AKT played a protective role during TAM-induced apoptosis, and that c-Cbl sensitized MCF-7 cells to TAM by modulating the expression of c-Src, and TAM-induced ERK and AKT activity.	Tamoxifen	158-161	Cbl proto-oncogene	Homo sapiens	126-131
21175263-16	2011	CONCLUSIONS: This study demonstrates that c-Src, ERK, and AKT played a protective role during TAM-induced apoptosis, and that c-Cbl sensitized MCF-7 cells to TAM by modulating the expression of c-Src, and TAM-induced ERK and AKT activity.	Tamoxifen	158-161	Cbl proto-oncogene	Homo sapiens	126-131
21130828-2	2011	The reduced form of vitamin B(12), cob(I)alamin {Cbl(I)}, obtained by reduction of hydroxocobalamin (OH-Cbl) with e.g. sodium borohydride, is one of the most powerful nucleophiles known.	Niacinamide	20-29	Cbl proto-oncogene	Homo sapiens	49-52
21130828-2	2011	The reduced form of vitamin B(12), cob(I)alamin {Cbl(I)}, obtained by reduction of hydroxocobalamin (OH-Cbl) with e.g. sodium borohydride, is one of the most powerful nucleophiles known.	Niacinamide	20-29	Cbl proto-oncogene	Homo sapiens	104-107
21130828-2	2011	The reduced form of vitamin B(12), cob(I)alamin {Cbl(I)}, obtained by reduction of hydroxocobalamin (OH-Cbl) with e.g. sodium borohydride, is one of the most powerful nucleophiles known.	Hydroxocobalamin	83-99	Cbl proto-oncogene	Homo sapiens	49-52
21130828-2	2011	The reduced form of vitamin B(12), cob(I)alamin {Cbl(I)}, obtained by reduction of hydroxocobalamin (OH-Cbl) with e.g. sodium borohydride, is one of the most powerful nucleophiles known.	Hydroxocobalamin	83-99	Cbl proto-oncogene	Homo sapiens	104-107
21130828-2	2011	The reduced form of vitamin B(12), cob(I)alamin {Cbl(I)}, obtained by reduction of hydroxocobalamin (OH-Cbl) with e.g. sodium borohydride, is one of the most powerful nucleophiles known.	sodium borohydride	119-137	Cbl proto-oncogene	Homo sapiens	49-52
21130828-3	2011	Cbl(I) was shown to react readily with the synthetic sweetener sucralose (1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosyl-4-chloro-4-deoxy-alpha-D-galactopyranoside) in an aqueous system to form an alkylcobalamin (Suc-Cbl).	trichlorosucrose	63-72	Cbl proto-oncogene	Homo sapiens	0-3
21130828-3	2011	Cbl(I) was shown to react readily with the synthetic sweetener sucralose (1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosyl-4-chloro-4-deoxy-alpha-D-galactopyranoside) in an aqueous system to form an alkylcobalamin (Suc-Cbl).	trichlorosucrose	63-72	Cbl proto-oncogene	Homo sapiens	218-221
21130828-3	2011	Cbl(I) was shown to react readily with the synthetic sweetener sucralose (1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosyl-4-chloro-4-deoxy-alpha-D-galactopyranoside) in an aqueous system to form an alkylcobalamin (Suc-Cbl).	trichlorosucrose	74-164	Cbl proto-oncogene	Homo sapiens	0-3
21130828-3	2011	Cbl(I) was shown to react readily with the synthetic sweetener sucralose (1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosyl-4-chloro-4-deoxy-alpha-D-galactopyranoside) in an aqueous system to form an alkylcobalamin (Suc-Cbl).	trichlorosucrose	74-164	Cbl proto-oncogene	Homo sapiens	218-221
21130828-3	2011	Cbl(I) was shown to react readily with the synthetic sweetener sucralose (1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosyl-4-chloro-4-deoxy-alpha-D-galactopyranoside) in an aqueous system to form an alkylcobalamin (Suc-Cbl).	alkylcobalamin	198-212	Cbl proto-oncogene	Homo sapiens	0-3
21130828-6	2011	Furthermore, in an in vitro study using human liver S9 with NADPH regeneration, in presence of OH-Cbl and sucralose, Suc-Cbl was shown to be formed.	NADP	60-65	Cbl proto-oncogene	Homo sapiens	98-101
21130828-6	2011	Furthermore, in an in vitro study using human liver S9 with NADPH regeneration, in presence of OH-Cbl and sucralose, Suc-Cbl was shown to be formed.	NADP	60-65	Cbl proto-oncogene	Homo sapiens	121-124
21130828-6	2011	Furthermore, in an in vitro study using human liver S9 with NADPH regeneration, in presence of OH-Cbl and sucralose, Suc-Cbl was shown to be formed.	trichlorosucrose	106-115	Cbl proto-oncogene	Homo sapiens	121-124
20940296-7	2011	Cbl can also interact with Vav2 directly in a Cbl Tyr-700-dependent manner.	Tyrosine	50-53	Cbl proto-oncogene	Homo sapiens	0-3
20940296-8	2011	A ubiquitin ligase-deficient Cbl mutant enhanced the morphological transformation of mammary epithelial cells induced by constitutively active Vav2; this effect requires an intact Cbl Tyr-700.	Tyrosine	184-187	Cbl proto-oncogene	Homo sapiens	29-32
20940296-8	2011	A ubiquitin ligase-deficient Cbl mutant enhanced the morphological transformation of mammary epithelial cells induced by constitutively active Vav2; this effect requires an intact Cbl Tyr-700.	Tyrosine	184-187	Cbl proto-oncogene	Homo sapiens	180-183
21128680-7	2011	The analysis confirmed that protonation of the phosphate leaves the major CNCbl structural parameters unaffected, so that 1 can be considered an "unmodified" Cbl solvate.	Phosphates	47-56	Cbl proto-oncogene	Homo sapiens	76-79
20940296-7	2011	Cbl can also interact with Vav2 directly in a Cbl Tyr-700-dependent manner.	Tyrosine	50-53	Cbl proto-oncogene	Homo sapiens	46-49
20876572-1	2010	Vitamin B(12) (cobalamin, Cbl) is essential to the function of two human enzymes, methionine synthase (MS) and methylmalonyl-CoA mutase (MUT).	Niacinamide	0-9	Cbl proto-oncogene	Homo sapiens	26-29
21163258-0	2011	An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding.	Arginine	12-20	Cbl proto-oncogene	Homo sapiens	121-126
21163258-0	2011	An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding.	Tyrosine	45-53	Cbl proto-oncogene	Homo sapiens	121-126
21163258-1	2011	Previously, we have demonstrated that the tyrosine phosphorylated hepatocyte growth factor receptor (Met) binds to the c-Cbl phosphotyrosine-recognition, tyrosine kinase binding (TKB) domain in a reverse orientation compared to other c-Cbl binding partners.	Tyrosine	42-50	Cbl proto-oncogene	Homo sapiens	119-124
21163258-1	2011	Previously, we have demonstrated that the tyrosine phosphorylated hepatocyte growth factor receptor (Met) binds to the c-Cbl phosphotyrosine-recognition, tyrosine kinase binding (TKB) domain in a reverse orientation compared to other c-Cbl binding partners.	Tyrosine	42-50	Cbl proto-oncogene	Homo sapiens	234-239
21163258-4	2011	Collated data indicates that both binding and orientation is dictated by the phosphorylated tyrosine and an adjacent arginine forming intra-peptide hydrogen bonds and aligning unidirectionally with complementary charges in the phosphotyrosine binding pocket of c-Cbl.	Tyrosine	92-100	Cbl proto-oncogene	Homo sapiens	261-266
21163258-4	2011	Collated data indicates that both binding and orientation is dictated by the phosphorylated tyrosine and an adjacent arginine forming intra-peptide hydrogen bonds and aligning unidirectionally with complementary charges in the phosphotyrosine binding pocket of c-Cbl.	Arginine	117-125	Cbl proto-oncogene	Homo sapiens	261-266
21163258-4	2011	Collated data indicates that both binding and orientation is dictated by the phosphorylated tyrosine and an adjacent arginine forming intra-peptide hydrogen bonds and aligning unidirectionally with complementary charges in the phosphotyrosine binding pocket of c-Cbl.	Hydrogen	148-156	Cbl proto-oncogene	Homo sapiens	261-266
21163258-4	2011	Collated data indicates that both binding and orientation is dictated by the phosphorylated tyrosine and an adjacent arginine forming intra-peptide hydrogen bonds and aligning unidirectionally with complementary charges in the phosphotyrosine binding pocket of c-Cbl.	Phosphotyrosine	227-242	Cbl proto-oncogene	Homo sapiens	261-266
21203488-4	2010	Here we demonstrate that tyrosine phosphorylation of the adaptor protein c-Cbl is required for KSHV induced membrane blebbing and macropinocytosis.	Tyrosine	25-33	Cbl proto-oncogene	Homo sapiens	73-78
21203488-5	2010	KSHV induced the tyrosine phosphorylation of c-Cbl as early as 1 min post-infection and was recruited to the sites of bleb formation.	Tyrosine	17-25	Cbl proto-oncogene	Homo sapiens	45-50
20876572-2	2010	The conversion of dietary Cbl to its cofactor forms, methyl-Cbl (MeCbl) for MS and adenosyl-Cbl (AdoCbl) for MUT, located in the cytosol and mitochondria, respectively, requires a complex pathway of intracellular processing and trafficking.	MeCbl	65-70	Cbl proto-oncogene	Homo sapiens	26-29
20876572-2	2010	The conversion of dietary Cbl to its cofactor forms, methyl-Cbl (MeCbl) for MS and adenosyl-Cbl (AdoCbl) for MUT, located in the cytosol and mitochondria, respectively, requires a complex pathway of intracellular processing and trafficking.	MeCbl	65-70	Cbl proto-oncogene	Homo sapiens	60-63
20876572-2	2010	The conversion of dietary Cbl to its cofactor forms, methyl-Cbl (MeCbl) for MS and adenosyl-Cbl (AdoCbl) for MUT, located in the cytosol and mitochondria, respectively, requires a complex pathway of intracellular processing and trafficking.	MeCbl	65-70	Cbl proto-oncogene	Homo sapiens	60-63
20082303-7	2010	Finally, quercetin increased the interaction between EGFR and Cbl, and also induced the tyrosine phosphorylation of Cbl.	Quercetin	9-18	Cbl proto-oncogene	Homo sapiens	62-65
20089427-1	2010	BACKGROUND: Maternal vitamin B(12) (Cbl) deficiency causes nutritional Cbl deficiency in breastfed infants.	Niacinamide	21-30	Cbl proto-oncogene	Homo sapiens	36-39
20622007-8	2010	Inhibition of hexokinase with 2-deoxyglucose blocked the transforming activity of CBL mutants and reduced activation of signaling mechanisms.	Deoxyglucose	30-44	Cbl proto-oncogene	Homo sapiens	82-85
20877636-0	2010	Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain.	Serine	11-17	Cbl proto-oncogene	Homo sapiens	133-138
20877636-0	2010	Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain.	Threonine	18-27	Cbl proto-oncogene	Homo sapiens	133-138
20298671-6	2010	Furthermore, the inhibition by the selected 5 fragments on the protein-peptide interaction was confirmed by their effect on pull-down assays of c-Cbl with the biotin-conjugated interaction peptides.	Biotin	159-165	Cbl proto-oncogene	Homo sapiens	144-149
20553999-7	2010	GM umbilical CBL levels were higher in neonates born to women living near a potential Pb-contaminated area (2.2 vs. 1.1 microg/dL) and those with friends, family or household members exposed to lead products (1.6 vs. 1.1 microg/dL).	Lead	86-88	Cbl proto-oncogene	Homo sapiens	13-16
20553999-9	2010	After adjustment for confounding, proximity to a Pb-contaminated area was the strongest environmental determinant of CBL levels among neonates with CBL concentrations of &gt; or =2 microg/dL (odds ratio=5.1; 95% CI=1.6, 16.7).	Lead	49-51	Cbl proto-oncogene	Homo sapiens	117-120
20553999-9	2010	After adjustment for confounding, proximity to a Pb-contaminated area was the strongest environmental determinant of CBL levels among neonates with CBL concentrations of &gt; or =2 microg/dL (odds ratio=5.1; 95% CI=1.6, 16.7).	Lead	49-51	Cbl proto-oncogene	Homo sapiens	148-151
20553999-10	2010	CONCLUSIONS: Metal concentrations were elevated in this population, and CBL levels were associated with proximity to Pb-contaminated areas.	Lead	117-119	Cbl proto-oncogene	Homo sapiens	72-75
20877636-8	2010	This obvious reduction in binding affinity, however, indicates that Cbl"s interactions with its TKB-centered binding partners may be more favorable in the absence of Ser/Thr phosphorylation, which is stimulation and context specific in vivo.	Serine	166-169	Cbl proto-oncogene	Homo sapiens	68-71
20877636-8	2010	This obvious reduction in binding affinity, however, indicates that Cbl"s interactions with its TKB-centered binding partners may be more favorable in the absence of Ser/Thr phosphorylation, which is stimulation and context specific in vivo.	Threonine	170-173	Cbl proto-oncogene	Homo sapiens	68-71
20379601-3	2010	The experimental support for this model of the binding interaction is provided by the consequences of the successful delivery of the CN-Cbl-insulin conjugate in the production of significantly decreased blood glucose levels in diabetic STZ-rat models.	Glucose	209-216	Cbl proto-oncogene	Homo sapiens	136-139
20379601-3	2010	The experimental support for this model of the binding interaction is provided by the consequences of the successful delivery of the CN-Cbl-insulin conjugate in the production of significantly decreased blood glucose levels in diabetic STZ-rat models.	Streptozocin	236-239	Cbl proto-oncogene	Homo sapiens	136-139
20051280-1	2010	Early diagnostics of cobalamin (Cbl, vitamin B(12)) deficiency is primarily based on measurements of the relevant metabolic markers in blood plasma--total B(12), specific Cbl-saturated transporter holo-transcobalamin (holoTC), and substrates of Cbl-dependent enzymatic reactions methylmalonic acid (MMA) and homocysteine (Hcy).	Vitamin B 12	21-30	Cbl proto-oncogene	Homo sapiens	32-35
20051280-1	2010	Early diagnostics of cobalamin (Cbl, vitamin B(12)) deficiency is primarily based on measurements of the relevant metabolic markers in blood plasma--total B(12), specific Cbl-saturated transporter holo-transcobalamin (holoTC), and substrates of Cbl-dependent enzymatic reactions methylmalonic acid (MMA) and homocysteine (Hcy).	Vitamin B 12	21-30	Cbl proto-oncogene	Homo sapiens	171-174
20051280-1	2010	Early diagnostics of cobalamin (Cbl, vitamin B(12)) deficiency is primarily based on measurements of the relevant metabolic markers in blood plasma--total B(12), specific Cbl-saturated transporter holo-transcobalamin (holoTC), and substrates of Cbl-dependent enzymatic reactions methylmalonic acid (MMA) and homocysteine (Hcy).	Vitamin B 12	21-30	Cbl proto-oncogene	Homo sapiens	171-174
20352340-1	2010	Transcobalamin (transcobalamin II, TC) transports plasma vitamin B(12) (cobalamin, Cbl) into cells.	Niacinamide	57-66	Cbl proto-oncogene	Homo sapiens	83-86
20352340-1	2010	Transcobalamin (transcobalamin II, TC) transports plasma vitamin B(12) (cobalamin, Cbl) into cells.	Vitamin B 12	5-14	Cbl proto-oncogene	Homo sapiens	83-86
20352340-2	2010	TC deficiency is a rare autosomal recessive disorder causing intracellular Cbl depletion, which in turn causes megaloblastic bone marrow failure, accumulation of homocysteine and methylmalonic acid, and methionine depletion.	Homocysteine	162-174	Cbl proto-oncogene	Homo sapiens	75-78
20352340-2	2010	TC deficiency is a rare autosomal recessive disorder causing intracellular Cbl depletion, which in turn causes megaloblastic bone marrow failure, accumulation of homocysteine and methylmalonic acid, and methionine depletion.	Methionine	203-213	Cbl proto-oncogene	Homo sapiens	75-78
20236940-8	2010	The docking proteins, Gab1 and c-Cbl, were also tyrosine-phosphorylated in these cells.	Tyrosine	48-56	Cbl proto-oncogene	Homo sapiens	31-36
20082303-7	2010	Finally, quercetin increased the interaction between EGFR and Cbl, and also induced the tyrosine phosphorylation of Cbl.	Quercetin	9-18	Cbl proto-oncogene	Homo sapiens	116-119
20082303-7	2010	Finally, quercetin increased the interaction between EGFR and Cbl, and also induced the tyrosine phosphorylation of Cbl.	Tyrosine	88-96	Cbl proto-oncogene	Homo sapiens	116-119
20071559-9	2010	Interestingly, insulin-induced tyrosine phosphorylation of Cbl and activation of TC10 were inhibited by progesterone at 10(-5) M. These results indicate that progesterone is implicated in insulin resistance during pregnancy by inhibiting the PI 3-kinase pathway at the step of 1) IRS-1 expression and 2) distal to Akt and 3) by suppressing the PI 3-kinase-independent pathway of TC10 activation by affecting Cbl phosphorylation.	Progesterone	158-170	Cbl proto-oncogene	Homo sapiens	408-411
20332299-9	2010	Whereas sulindac metabolites inhibited phosphorylation of EGFR pY1068, they increased phosphorylation of EGFR pY1045, the docking site where c-Cbl binds, thereby enabling receptor ubiquitination and degradation.	Sulindac	8-16	Cbl proto-oncogene	Homo sapiens	141-146
20215522-3	2010	Cisplatin treatment led to an increase in initial EGFR phosphorylation at Y1045, the binding site of ubiquitin ligase, Casitas B-lineage lymphoma (c-Cbl), followed by ubiquitination in the relatively cisplatin-sensitive cell lines.	Cisplatin	0-9	Cbl proto-oncogene	Homo sapiens	149-152
20215522-8	2010	Transfection of WT c-Cbl enhanced EGFR degradation and cisplatin-induced cytotoxicity compared with control vector.	Cisplatin	55-64	Cbl proto-oncogene	Homo sapiens	19-24
19450681-3	2009	The caspase cleavage site at aspartic acid D1000 is adjacent to tyrosine Y1001, which when phosphorylated upon MET activation, is involved in CBL recruitment, allowing receptor ubiquitination and down regulation.	Aspartic Acid	29-42	Cbl proto-oncogene	Homo sapiens	142-145
20237427-3	2010	Although no genetic evidence existed suggesting its role in human carcinogenesis, the recent discovery of c-CBL mutations in myeloid cancers has unveiled a unique oncogenic mechanism mediated by gain-of-function of a mutated tumor suppressor, closely associated with allelic conversion of 11q arms.	alpha7 agonists 11q	289-292	Cbl proto-oncogene	Homo sapiens	106-111
20126411-4	2010	METHODS AND FINDINGS: Using archival formalin-fixed paraffin embedded (FFPE) extracted genomic DNA, we show that c-CBL mutations occur in somatic fashion for lung cancers.	Formaldehyde	37-45	Cbl proto-oncogene	Homo sapiens	113-118
20126411-4	2010	METHODS AND FINDINGS: Using archival formalin-fixed paraffin embedded (FFPE) extracted genomic DNA, we show that c-CBL mutations occur in somatic fashion for lung cancers.	Paraffin	52-60	Cbl proto-oncogene	Homo sapiens	113-118
19947936-7	2009	c-Cbl association with EGFR abolished by AG1478 was not reestablished after tyrphostin cessation.	RTKI cpd	41-47	Cbl proto-oncogene	Homo sapiens	0-5
19828455-4	2009	Desensitization of ERK1/2 activity by etorphine is associated with down-regulation of EGF receptors, an effect mediated by the ubiquitin ligase c-Cbl.	Etorphine	38-47	Cbl proto-oncogene	Homo sapiens	144-149
19828455-8	2009	Conversely, overexpression of c-Src as well as down-regulation of c-Cbl by small interfering RNA results in persistent etorphine-induced stimulation of ERK1/2 activity.	Etorphine	119-128	Cbl proto-oncogene	Homo sapiens	66-71
19457607-0	2009	Arsenic trioxide induces apoptosis and G2/M phase arrest by inducing Cbl to inhibit PI3K/Akt signaling and thereby regulate p53 activation.	Arsenic Trioxide	0-16	Cbl proto-oncogene	Homo sapiens	69-72
19457607-8	2009	In addition, ATO up-regulated the expression of Cbl proteins in both cell lines.	Arsenic Trioxide	13-16	Cbl proto-oncogene	Homo sapiens	48-51
19457607-9	2009	Inhibition of Cbl with the proteasome inhibitor Ps341 decreased apoptosis in NB4 cells and increased the G2/M phase arrest of MGC803 cells, and it also prolonged the activation of PI3K/Akt by ATO.	Arsenic Trioxide	192-195	Cbl proto-oncogene	Homo sapiens	14-17
19457607-11	2009	These results demonstrate that inhibition of PI3K/Akt signaling by Cbl is involved in both ATO-induced apoptosis of NB4 cells and ATO-induced G2/M phase arrest of gastric cancer cells.	Arsenic Trioxide	91-94	Cbl proto-oncogene	Homo sapiens	67-70
19457607-11	2009	These results demonstrate that inhibition of PI3K/Akt signaling by Cbl is involved in both ATO-induced apoptosis of NB4 cells and ATO-induced G2/M phase arrest of gastric cancer cells.	Arsenic Trioxide	130-133	Cbl proto-oncogene	Homo sapiens	67-70
19635790-0	2009	c-Cbl tyrosine kinase-binding domain mutant G306E abolishes the interaction of c-Cbl with CD38 and fails to promote retinoic acid-induced cell differentiation and G0 arrest.	Tretinoin	116-129	Cbl proto-oncogene	Homo sapiens	0-5
19635790-4	2009	Unlike wild-type (WT) c-Cbl, the G306E mutant c-Cbl fails to propel RA-induced differentiation, and disrupts the normal association with CD38.	Tretinoin	68-70	Cbl proto-oncogene	Homo sapiens	46-51
19635790-12	2009	Without the G306E mutation the c-Cbl unites CD38 with the signaling complex and delivers a MAPK signal that drives RA-induced differentiation.	Tretinoin	115-117	Cbl proto-oncogene	Homo sapiens	31-36
19635790-13	2009	The results demonstrate the importance of the Gly306 residue in the ability of c-Cbl to propel RA-induced differentiation.	Tretinoin	95-97	Cbl proto-oncogene	Homo sapiens	79-84
20071559-9	2010	Interestingly, insulin-induced tyrosine phosphorylation of Cbl and activation of TC10 were inhibited by progesterone at 10(-5) M. These results indicate that progesterone is implicated in insulin resistance during pregnancy by inhibiting the PI 3-kinase pathway at the step of 1) IRS-1 expression and 2) distal to Akt and 3) by suppressing the PI 3-kinase-independent pathway of TC10 activation by affecting Cbl phosphorylation.	Tyrosine	31-39	Cbl proto-oncogene	Homo sapiens	59-62
20071559-9	2010	Interestingly, insulin-induced tyrosine phosphorylation of Cbl and activation of TC10 were inhibited by progesterone at 10(-5) M. These results indicate that progesterone is implicated in insulin resistance during pregnancy by inhibiting the PI 3-kinase pathway at the step of 1) IRS-1 expression and 2) distal to Akt and 3) by suppressing the PI 3-kinase-independent pathway of TC10 activation by affecting Cbl phosphorylation.	Tyrosine	31-39	Cbl proto-oncogene	Homo sapiens	408-411
20071559-9	2010	Interestingly, insulin-induced tyrosine phosphorylation of Cbl and activation of TC10 were inhibited by progesterone at 10(-5) M. These results indicate that progesterone is implicated in insulin resistance during pregnancy by inhibiting the PI 3-kinase pathway at the step of 1) IRS-1 expression and 2) distal to Akt and 3) by suppressing the PI 3-kinase-independent pathway of TC10 activation by affecting Cbl phosphorylation.	Progesterone	104-116	Cbl proto-oncogene	Homo sapiens	59-62
20071559-9	2010	Interestingly, insulin-induced tyrosine phosphorylation of Cbl and activation of TC10 were inhibited by progesterone at 10(-5) M. These results indicate that progesterone is implicated in insulin resistance during pregnancy by inhibiting the PI 3-kinase pathway at the step of 1) IRS-1 expression and 2) distal to Akt and 3) by suppressing the PI 3-kinase-independent pathway of TC10 activation by affecting Cbl phosphorylation.	Progesterone	104-116	Cbl proto-oncogene	Homo sapiens	408-411
20071559-9	2010	Interestingly, insulin-induced tyrosine phosphorylation of Cbl and activation of TC10 were inhibited by progesterone at 10(-5) M. These results indicate that progesterone is implicated in insulin resistance during pregnancy by inhibiting the PI 3-kinase pathway at the step of 1) IRS-1 expression and 2) distal to Akt and 3) by suppressing the PI 3-kinase-independent pathway of TC10 activation by affecting Cbl phosphorylation.	Progesterone	158-170	Cbl proto-oncogene	Homo sapiens	59-62
19933577-2	2010	Here we show that free or protein-bound dihydroflavins can serve as the reductant of Co(2+)Cbl bound in the active site of PduO-type ATP-dependent corrinoid adenosyltransferase enzymes.	dihydroflavins	40-54	Cbl proto-oncogene	Homo sapiens	91-94
19933577-2	2010	Here we show that free or protein-bound dihydroflavins can serve as the reductant of Co(2+)Cbl bound in the active site of PduO-type ATP-dependent corrinoid adenosyltransferase enzymes.	Adenosine Triphosphate	133-136	Cbl proto-oncogene	Homo sapiens	91-94
19933577-3	2010	Free dihydroflavins (dihydroriboflavin, FMNH(2), and FADH(2)) effectively drove the adenosylation of Co(2+)Cbl by the human and bacterial PduO-type enzymes at very low concentrations (1 microm).	dihydroflavins	5-19	Cbl proto-oncogene	Homo sapiens	107-110
19933577-3	2010	Free dihydroflavins (dihydroriboflavin, FMNH(2), and FADH(2)) effectively drove the adenosylation of Co(2+)Cbl by the human and bacterial PduO-type enzymes at very low concentrations (1 microm).	dihydroriboflavin	21-38	Cbl proto-oncogene	Homo sapiens	107-110
20029031-3	2009	In experiments with full-length alanine substitution mutants, we demonstrated that the RF tail of Cbl regulated biochemically distinct checkpoints in the endocytosis of EGFR.	Alanine	32-39	Cbl proto-oncogene	Homo sapiens	98-101
20029031-4	2009	The Cbl- and ubiquitin-dependent degradation of the regulator of internalization hSprouty2 was compromised by the Val(431)--&gt; Ala mutation, whereas the Cbl- and EGFR-dependent dephosphorylation or degradation of the endosomal trafficking regulator Hrs was compromised by the Phe(434)--&gt; Ala mutation.	Valine	114-117	Cbl proto-oncogene	Homo sapiens	4-7
20029031-4	2009	The Cbl- and ubiquitin-dependent degradation of the regulator of internalization hSprouty2 was compromised by the Val(431)--&gt; Ala mutation, whereas the Cbl- and EGFR-dependent dephosphorylation or degradation of the endosomal trafficking regulator Hrs was compromised by the Phe(434)--&gt; Ala mutation.	Alanine	129-132	Cbl proto-oncogene	Homo sapiens	4-7
20029031-4	2009	The Cbl- and ubiquitin-dependent degradation of the regulator of internalization hSprouty2 was compromised by the Val(431)--&gt; Ala mutation, whereas the Cbl- and EGFR-dependent dephosphorylation or degradation of the endosomal trafficking regulator Hrs was compromised by the Phe(434)--&gt; Ala mutation.	Phenylalanine	278-281	Cbl proto-oncogene	Homo sapiens	4-7
20029031-4	2009	The Cbl- and ubiquitin-dependent degradation of the regulator of internalization hSprouty2 was compromised by the Val(431)--&gt; Ala mutation, whereas the Cbl- and EGFR-dependent dephosphorylation or degradation of the endosomal trafficking regulator Hrs was compromised by the Phe(434)--&gt; Ala mutation.	Alanine	293-296	Cbl proto-oncogene	Homo sapiens	4-7
19828455-0	2009	Down-regulation of c-Cbl by morphine accounts for persistent ERK1/2 signaling in delta-opioid receptor-expressing HEK293 cells.	Morphine	28-36	Cbl proto-oncogene	Homo sapiens	19-24
19450681-3	2009	The caspase cleavage site at aspartic acid D1000 is adjacent to tyrosine Y1001, which when phosphorylated upon MET activation, is involved in CBL recruitment, allowing receptor ubiquitination and down regulation.	Tyrosine	64-72	Cbl proto-oncogene	Homo sapiens	142-145
19394404-1	2009	Glial cells, myelin and the interstitium are the structures of the mammalian central nervous system (CNS) mainly affected by vitamin B(12) (cobalamin, Cbl) deficiency.	Niacinamide	125-134	Cbl proto-oncogene	Homo sapiens	151-154
19419964-0	2009	Syk tyrosine 317 negatively regulates osteoclast function via the ubiquitin-protein isopeptide ligase activity of Cbl.	Tyrosine	4-12	Cbl proto-oncogene	Homo sapiens	114-117
19419964-3	2009	We demonstrate that Cbl negatively regulates OC function by interacting with Syk(Y317).	y317	81-85	Cbl proto-oncogene	Homo sapiens	20-23
19419964-5	2009	Syk(Y317) suppresses cytoskeletal organization and function while binding the ubiquitin-protein isopeptide ligase Cbl.	y317	4-8	Cbl proto-oncogene	Homo sapiens	114-117
19546888-3	2009	NGF deprivation also induced rapid loss of tyrosine phosphorylation (and most likely, activation) of c-Cbl.	Tyrosine	43-51	Cbl proto-oncogene	Homo sapiens	101-106
19644140-4	2009	Wild-type receptor tyrosine kinases are efficiently targeted for degradation upon activation, in a process that requires Cbl-mediated monoubiquitination of receptor lysines.	Lysine	165-172	Cbl proto-oncogene	Homo sapiens	121-124
19501014-0	2009	Potassium nutrition, sodium toxicity, and calcium signaling: connections through the CBL-CIPK network.	Potassium	0-9	Cbl proto-oncogene	Homo sapiens	85-88
19501014-0	2009	Potassium nutrition, sodium toxicity, and calcium signaling: connections through the CBL-CIPK network.	Sodium	21-27	Cbl proto-oncogene	Homo sapiens	85-88
19501014-0	2009	Potassium nutrition, sodium toxicity, and calcium signaling: connections through the CBL-CIPK network.	Calcium	42-49	Cbl proto-oncogene	Homo sapiens	85-88
19183301-7	2009	Cbl family ubiquitin ligases, along with a set of phosphotyrosine-binding adaptors (e.g., Grb2), integrate receptor endocytosis into the densely wired networks of signal transduction pathways, which are involved in health and disease.	Phosphotyrosine	50-65	Cbl proto-oncogene	Homo sapiens	0-3
19298066-1	2009	The one-electron-reduced form of vitamin B(12), cob(II)alamin (Co(2+)Cbl), is found in several essential human enzymes, including the cobalamin-dependent methionine synthase (MetH).	Niacinamide	33-42	Cbl proto-oncogene	Homo sapiens	69-72
19298066-1	2009	The one-electron-reduced form of vitamin B(12), cob(II)alamin (Co(2+)Cbl), is found in several essential human enzymes, including the cobalamin-dependent methionine synthase (MetH).	cob(II)alamin	48-61	Cbl proto-oncogene	Homo sapiens	69-72
19298066-2	2009	In this work, experimentally validated electronic structure descriptions for two "base-off" Co(2+)Cbl species have been generated using a combined spectroscopic and computational approach, so as to obtain definitive clues as to how these and related enzymes catalyze the thermodynamically challenging reduction of Co(2+)Cbl to cob(I)alamin (Co(1+)Cbl).	Vitamin B 12	327-339	Cbl proto-oncogene	Homo sapiens	98-101
19298066-8	2009	These results provide important clues to the mechanism of enzymatic Co(2+)Cbl --&gt; Co(1+)Cbl reduction.	Cobalt(2+)	68-74	Cbl proto-oncogene	Homo sapiens	91-94
19276253-13	2009	FLT3 ligand-dependent hyperproliferation of CBL mutant cells could be abrogated by treatment with the FLT3 PTK inhibitor PKC412 (midostaurin).	midostaurin	129-140	Cbl proto-oncogene	Homo sapiens	44-47
19320426-1	2009	4-Chlorobenzoate:CoA ligase (CBL) belongs to the adenylate-forming family of enzymes that catalyze a two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein.	carboxylate	139-150	Cbl proto-oncogene	Homo sapiens	0-27
19320426-1	2009	4-Chlorobenzoate:CoA ligase (CBL) belongs to the adenylate-forming family of enzymes that catalyze a two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein.	carboxylate	139-150	Cbl proto-oncogene	Homo sapiens	29-32
19320426-1	2009	4-Chlorobenzoate:CoA ligase (CBL) belongs to the adenylate-forming family of enzymes that catalyze a two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein.	carboxylate	199-210	Cbl proto-oncogene	Homo sapiens	0-27
19320426-1	2009	4-Chlorobenzoate:CoA ligase (CBL) belongs to the adenylate-forming family of enzymes that catalyze a two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein.	carboxylate	199-210	Cbl proto-oncogene	Homo sapiens	29-32
19320426-1	2009	4-Chlorobenzoate:CoA ligase (CBL) belongs to the adenylate-forming family of enzymes that catalyze a two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein.	Pantetheine	218-229	Cbl proto-oncogene	Homo sapiens	0-27
19320426-1	2009	4-Chlorobenzoate:CoA ligase (CBL) belongs to the adenylate-forming family of enzymes that catalyze a two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein.	Pantetheine	218-229	Cbl proto-oncogene	Homo sapiens	29-32
19223002-0	2009	Oxaliplatin enhances TRAIL-induced apoptosis in gastric cancer cells by CBL-regulated death receptor redistribution in lipid rafts.	Oxaliplatin	0-11	Cbl proto-oncogene	Homo sapiens	72-75
19223002-5	2009	Furthermore, the expression of the casitas B-lineage lymphoma (Cbl) family was downregulated by oxaliplatin.	Oxaliplatin	96-107	Cbl proto-oncogene	Homo sapiens	35-61
19223002-5	2009	Furthermore, the expression of the casitas B-lineage lymphoma (Cbl) family was downregulated by oxaliplatin.	Oxaliplatin	96-107	Cbl proto-oncogene	Homo sapiens	63-66
19223002-6	2009	Transfection of c-Cbl or Cbl-b partially reversed oxaliplatin-induced lipid raft aggregation.	Oxaliplatin	50-61	Cbl proto-oncogene	Homo sapiens	16-21
19223002-7	2009	These results indicated that oxaliplatin enhanced TRAIL-induced gastric cancer cell apoptosis at least partially through Cbl-regulated death receptor redistribution in lipid rafts.	Oxaliplatin	29-40	Cbl proto-oncogene	Homo sapiens	121-124
19258424-0	2009	The phytochemical piceatannol induces the loss of CBL and CBL-associated proteins.	3,3',4,5'-tetrahydroxystilbene	18-29	Cbl proto-oncogene	Homo sapiens	50-53
19258424-0	2009	The phytochemical piceatannol induces the loss of CBL and CBL-associated proteins.	3,3',4,5'-tetrahydroxystilbene	18-29	Cbl proto-oncogene	Homo sapiens	58-61
19258424-3	2009	Herein, we show that the hydroxystilbene, piceatannol, and related catechol ring-containing compounds are able to induce the loss of the Cbl family of proteins.	hydroxystilbene	25-40	Cbl proto-oncogene	Homo sapiens	137-140
19258424-3	2009	Herein, we show that the hydroxystilbene, piceatannol, and related catechol ring-containing compounds are able to induce the loss of the Cbl family of proteins.	3,3',4,5'-tetrahydroxystilbene	42-53	Cbl proto-oncogene	Homo sapiens	137-140
19258424-3	2009	Herein, we show that the hydroxystilbene, piceatannol, and related catechol ring-containing compounds are able to induce the loss of the Cbl family of proteins.	catechol	67-75	Cbl proto-oncogene	Homo sapiens	137-140
19258424-5	2009	Screening of a small library of piceatannol-like compounds indicated that aromaticity and a catechol ring were required for the induction of Cbl loss.	3,3',4,5'-tetrahydroxystilbene	32-43	Cbl proto-oncogene	Homo sapiens	141-144
19258424-5	2009	Screening of a small library of piceatannol-like compounds indicated that aromaticity and a catechol ring were required for the induction of Cbl loss.	catechol	92-100	Cbl proto-oncogene	Homo sapiens	141-144
19258424-6	2009	Further examination of these two chemical properties showed that the oxidative conversion of the catechol ring of piceatannol into a highly reactive O-benzoquinone was the cause of piceatannol-induced Cbl loss.	catechol	97-105	Cbl proto-oncogene	Homo sapiens	201-204
19258424-6	2009	Further examination of these two chemical properties showed that the oxidative conversion of the catechol ring of piceatannol into a highly reactive O-benzoquinone was the cause of piceatannol-induced Cbl loss.	3,3',4,5'-tetrahydroxystilbene	114-125	Cbl proto-oncogene	Homo sapiens	201-204
19258424-6	2009	Further examination of these two chemical properties showed that the oxidative conversion of the catechol ring of piceatannol into a highly reactive O-benzoquinone was the cause of piceatannol-induced Cbl loss.	2-benzoquinone	149-163	Cbl proto-oncogene	Homo sapiens	201-204
19258424-6	2009	Further examination of these two chemical properties showed that the oxidative conversion of the catechol ring of piceatannol into a highly reactive O-benzoquinone was the cause of piceatannol-induced Cbl loss.	3,3',4,5'-tetrahydroxystilbene	181-192	Cbl proto-oncogene	Homo sapiens	201-204
19258424-7	2009	Characterization of the Cbl selectivity of piceatannol-induced protein loss revealed that this compound was also able to induce the functional loss of specific Cbl-associated proteins involved in signaling pathways commonly associated with cancer.	3,3',4,5'-tetrahydroxystilbene	43-54	Cbl proto-oncogene	Homo sapiens	24-27
19258424-7	2009	Characterization of the Cbl selectivity of piceatannol-induced protein loss revealed that this compound was also able to induce the functional loss of specific Cbl-associated proteins involved in signaling pathways commonly associated with cancer.	3,3',4,5'-tetrahydroxystilbene	43-54	Cbl proto-oncogene	Homo sapiens	160-163
18951974-6	2009	Consistent with this observation, tyrosine 1045 on the EGFR, the c-cbl binding site, exhibited less phosphorylation following stimulation with AR than following stimulation with EGF.	Tyrosine	34-42	Cbl proto-oncogene	Homo sapiens	65-70
19268472-3	2009	To understand the manifold interactions of CIN85, we present a detailed high-resolution solution structural study of CIN85A and CIN85B binding to proline-arginine peptides derived from the cognate ligands Cbl and Cbl-b.	Proline	146-153	Cbl proto-oncogene	Homo sapiens	205-208
19343001-6	2009	It should be noted that bufalin transiently activated the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway and then inhibited it completely, and upregulated the Casitas B-lineage lymphoma (Cbl) family of ubiquitin ligases, upstream modulators of PI3K.	bufalin	24-31	Cbl proto-oncogene	Homo sapiens	171-197
19236749-0	2009	[Effects of Bufalin on SYK and CBL family proteins in induction of HL-60 cell apoptosis].	bufalin	12-19	Cbl proto-oncogene	Homo sapiens	31-34
19236749-1	2009	The study was aimed to explore the mechanism of SYK and CBL family of ubiquitin ligases in Bufalin-induced HL-60 cells apoptosis.	bufalin	91-98	Cbl proto-oncogene	Homo sapiens	56-59
19236749-7	2009	SYK was quickly phosphorylated, and the expressions of CBL and CBL-b were down-regulated after treatment with Bufalin.	bufalin	110-117	Cbl proto-oncogene	Homo sapiens	55-58
19343001-6	2009	It should be noted that bufalin transiently activated the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway and then inhibited it completely, and upregulated the Casitas B-lineage lymphoma (Cbl) family of ubiquitin ligases, upstream modulators of PI3K.	bufalin	24-31	Cbl proto-oncogene	Homo sapiens	199-202
18974118-8	2008	RA causes the gradual down-regulation and eventual loss of c-Cbl expression, resulting in loss of the Cbl-CD38 interaction, suggesting that c-Cbl plays a relatively early role in promoting RA-induced differentiation.	Tretinoin	189-191	Cbl proto-oncogene	Homo sapiens	140-145
18798873-0	2009	AtCIPK8, a CBL-interacting protein kinase, regulates the low-affinity phase of the primary nitrate response.	Nitrates	91-98	Cbl proto-oncogene	Homo sapiens	11-14
18798873-4	2009	In this study, a calcineurin B-like (CBL) -interacting protein kinase (CIPK) gene, CIPK8, was found to be involved in early nitrate signaling.	Nitrates	124-131	Cbl proto-oncogene	Homo sapiens	37-40
18798873-10	2009	Taken together, our results indicate that CBL-CIPK networks are responsible not only for stress responses and potassium shortage, but also for nitrate sensing.	Potassium	110-119	Cbl proto-oncogene	Homo sapiens	42-45
18798873-10	2009	Taken together, our results indicate that CBL-CIPK networks are responsible not only for stress responses and potassium shortage, but also for nitrate sensing.	Nitrates	143-150	Cbl proto-oncogene	Homo sapiens	42-45
18974118-0	2008	c-Cbl interacts with CD38 and promotes retinoic acid-induced differentiation and G0 arrest of human myeloblastic leukemia cells.	Tretinoin	39-52	Cbl proto-oncogene	Homo sapiens	0-5
18974118-4	2008	Stable transfectants ectopically expressing c-Cbl underwent myeloid differentiation faster than wild-type (wt) cells when treated with RA.	Tretinoin	135-137	Cbl proto-oncogene	Homo sapiens	44-49
18974118-5	2008	In contrast, c-Cbl knockdown stable transfectants differentiated slower than wt cells when treated with RA.	Tretinoin	104-106	Cbl proto-oncogene	Homo sapiens	13-18
18974118-6	2008	Cells ectopically expressing c-Cbl had enhanced CD38 expression when treated with RA, and cells ectopically expressing CD38 had enhanced c-Cbl expression, even without with RA, suggesting an interaction between c-Cbl and CD38.	Tretinoin	82-84	Cbl proto-oncogene	Homo sapiens	29-34
18974118-8	2008	RA causes the gradual down-regulation and eventual loss of c-Cbl expression, resulting in loss of the Cbl-CD38 interaction, suggesting that c-Cbl plays a relatively early role in promoting RA-induced differentiation.	Tretinoin	0-2	Cbl proto-oncogene	Homo sapiens	59-64
18974118-8	2008	RA causes the gradual down-regulation and eventual loss of c-Cbl expression, resulting in loss of the Cbl-CD38 interaction, suggesting that c-Cbl plays a relatively early role in promoting RA-induced differentiation.	Tretinoin	0-2	Cbl proto-oncogene	Homo sapiens	61-64
18974118-8	2008	RA causes the gradual down-regulation and eventual loss of c-Cbl expression, resulting in loss of the Cbl-CD38 interaction, suggesting that c-Cbl plays a relatively early role in promoting RA-induced differentiation.	Tretinoin	0-2	Cbl proto-oncogene	Homo sapiens	140-145
18596201-4	2008	To understand the mechanism by which the UBA domains specifically interact with Ub with different affinities, we determined the solution NMR structures of these two UBA domains, cUBA from human c-Cbl and UBAb from Cbl-b.	UBP 310	41-44	Cbl proto-oncogene	Homo sapiens	194-199
18662810-1	2008	A new calcium dependent GalNAc/Gal specific lectin was isolated from the serum of Indian catfish, Clarias batrachus and designated as C. batrachus lectin (CBL).	Calcium	6-13	Cbl proto-oncogene	Homo sapiens	155-158
19054707-0	2009	The CBL-CIPK network in plant calcium signaling.	Calcium	30-37	Cbl proto-oncogene	Homo sapiens	4-7
19764654-11	2009	Treatment of cells with proteasomal inhibition MG132 blocked the loss of Cbl only partially.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	47-52	Cbl proto-oncogene	Homo sapiens	73-76
18785232-8	2008	Cbl therapy led to improvements in Hcy and MMA levels in all groups, and PN in PD-IPN patients stabilized during therapy.	Homocysteine	35-38	Cbl proto-oncogene	Homo sapiens	0-3
18785232-8	2008	Cbl therapy led to improvements in Hcy and MMA levels in all groups, and PN in PD-IPN patients stabilized during therapy.	Methylmalonic Acid	43-46	Cbl proto-oncogene	Homo sapiens	0-3
18797457-7	2008	Dasatinib also inhibited ligand-induced binding of EphA2 to the ubiquitin ligase Cbl, and the internalisation and degradation of EphA2, suggesting that these processes are dependent on kinase activity.	Dasatinib	0-9	Cbl proto-oncogene	Homo sapiens	81-84
18974118-9	2008	RA-induced differentiation can thus be propelled by c-Cbl and by CD38, both of which bind together, enhance the expression of each other, and cause MAPK signaling.	Tretinoin	0-2	Cbl proto-oncogene	Homo sapiens	52-57
18974118-10	2008	There thus seems to be a cooperative role for c-Cbl and CD38, reflected in their direct binding, in propulsion of RA-induced differentiation.	Tretinoin	114-116	Cbl proto-oncogene	Homo sapiens	46-51
18400375-9	2008	Further studies showed that PD153035, which does not reverse ligand-induced EGFR down-regulation, blocks EGF-induced EGFR activation as well as EGFR"s binding to c-cbl and Grb2.	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	28-36	Cbl proto-oncogene	Homo sapiens	162-167
18606554-1	2008	Derivatives of vitamin B(12) (cobalamin, Cbl) are required for activity of the mitochondrial enzyme L-methylmalonyl-CoA mutase and the cytoplasmic enzyme methionine synthase in human cells.	Niacinamide	15-24	Cbl proto-oncogene	Homo sapiens	41-44
18606554-3	2008	The amount of Cbl bound to this protein varied in fibroblasts from patients with different genetic defects affecting cobalamin metabolism.	Vitamin B 12	117-126	Cbl proto-oncogene	Homo sapiens	14-17
18606554-5	2008	Increased Cbl bound TC levels were confirmed in whole cell extracts in at least one cell line from both the cblB and mut classes of inborn errors of cobalamin metabolism.	Vitamin B 12	149-158	Cbl proto-oncogene	Homo sapiens	10-13
18680311-2	2008	The SH3 domains of CIN85 bind to a proline-rich region of Cbl.	Proline	35-42	Cbl proto-oncogene	Homo sapiens	58-61
18620418-7	2008	Previously, we determined the structure of 4-chlorobenzoate:CoA ligase (CBL) in the adenylate forming conformation bound to 4-chlorobenzoate.	4-chlorobenzoic acid	43-59	Cbl proto-oncogene	Homo sapiens	72-75
18663086-4	2008	Adenovirus-mediated overexpression of a c-Cbl mutant that ablates the major tyrosine phosphorylation sites attenuated the Akt and the mammalian target of rapamycin activation and decreased the proliferation and migration of smooth muscle cells in response to PDGF-BB or fibroblast growth factor.	Tyrosine	76-84	Cbl proto-oncogene	Homo sapiens	40-45
18620418-9	2008	We have determined the structure of CBL in the original adenylate-forming conformation, bound to the adenylate intermediate.	Adenosine Monophosphate	56-65	Cbl proto-oncogene	Homo sapiens	36-39
18620421-4	2008	In conformation 1, CBL is poised to catalyze the adenylation of 4-chlorobenzoate (4-CB) with ATP (partial reaction 1), and in conformation 2, CBL is poised to catalyze the formation of 4-CB-CoA from 4-CB-AMP and CoA (partial reaction 2).	4-chlorobenzoic acid	64-80	Cbl proto-oncogene	Homo sapiens	19-22
18620421-4	2008	In conformation 1, CBL is poised to catalyze the adenylation of 4-chlorobenzoate (4-CB) with ATP (partial reaction 1), and in conformation 2, CBL is poised to catalyze the formation of 4-CB-CoA from 4-CB-AMP and CoA (partial reaction 2).	4-chlorobenzoic acid	64-80	Cbl proto-oncogene	Homo sapiens	142-145
18519587-4	2008	The stimulation-dependent ubiquitination of gp130 was mediated by c-Cbl, an E3 ligase, which was recruited to gp130 in a tyrosine-phosphorylated SHP2-dependent manner.	Tyrosine	121-129	Cbl proto-oncogene	Homo sapiens	66-71
18235045-0	2008	Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells.	Imatinib Mesylate	87-95	Cbl proto-oncogene	Homo sapiens	60-65
18620421-4	2008	In conformation 1, CBL is poised to catalyze the adenylation of 4-chlorobenzoate (4-CB) with ATP (partial reaction 1), and in conformation 2, CBL is poised to catalyze the formation of 4-CB-CoA from 4-CB-AMP and CoA (partial reaction 2).	4-chlorobenzoic acid	82-86	Cbl proto-oncogene	Homo sapiens	19-22
18620421-4	2008	In conformation 1, CBL is poised to catalyze the adenylation of 4-chlorobenzoate (4-CB) with ATP (partial reaction 1), and in conformation 2, CBL is poised to catalyze the formation of 4-CB-CoA from 4-CB-AMP and CoA (partial reaction 2).	4-chlorobenzoic acid	82-86	Cbl proto-oncogene	Homo sapiens	142-145
18620421-4	2008	In conformation 1, CBL is poised to catalyze the adenylation of 4-chlorobenzoate (4-CB) with ATP (partial reaction 1), and in conformation 2, CBL is poised to catalyze the formation of 4-CB-CoA from 4-CB-AMP and CoA (partial reaction 2).	Adenosine Triphosphate	93-96	Cbl proto-oncogene	Homo sapiens	19-22
18620421-4	2008	In conformation 1, CBL is poised to catalyze the adenylation of 4-chlorobenzoate (4-CB) with ATP (partial reaction 1), and in conformation 2, CBL is poised to catalyze the formation of 4-CB-CoA from 4-CB-AMP and CoA (partial reaction 2).	Adenosine Triphosphate	93-96	Cbl proto-oncogene	Homo sapiens	142-145
18620421-4	2008	In conformation 1, CBL is poised to catalyze the adenylation of 4-chlorobenzoate (4-CB) with ATP (partial reaction 1), and in conformation 2, CBL is poised to catalyze the formation of 4-CB-CoA from 4-CB-AMP and CoA (partial reaction 2).	4-chlorobenzoyl coenzyme A	185-193	Cbl proto-oncogene	Homo sapiens	19-22
18620421-4	2008	In conformation 1, CBL is poised to catalyze the adenylation of 4-chlorobenzoate (4-CB) with ATP (partial reaction 1), and in conformation 2, CBL is poised to catalyze the formation of 4-CB-CoA from 4-CB-AMP and CoA (partial reaction 2).	4-chlorobenzoyl coenzyme A	185-193	Cbl proto-oncogene	Homo sapiens	142-145
18620421-4	2008	In conformation 1, CBL is poised to catalyze the adenylation of 4-chlorobenzoate (4-CB) with ATP (partial reaction 1), and in conformation 2, CBL is poised to catalyze the formation of 4-CB-CoA from 4-CB-AMP and CoA (partial reaction 2).	4-cb-amp	199-207	Cbl proto-oncogene	Homo sapiens	19-22
18620421-4	2008	In conformation 1, CBL is poised to catalyze the adenylation of 4-chlorobenzoate (4-CB) with ATP (partial reaction 1), and in conformation 2, CBL is poised to catalyze the formation of 4-CB-CoA from 4-CB-AMP and CoA (partial reaction 2).	4-cb-amp	199-207	Cbl proto-oncogene	Homo sapiens	142-145
18620421-9	2008	First, wild-type CBL is activated by Mg (2+) (a 12-75-fold increase in activity is observed depending on assay conditions) and its kinetic mechanism (ping-pong) supports the structure-derived prediction that PP i dissociation must precede the switch from conformation 1 to conformation 2 and therefore CoA binding.	mg (2+)	37-44	Cbl proto-oncogene	Homo sapiens	17-20
18620421-10	2008	Also, transient kinetic analysis of wild-type CBL identified the rate-limiting step of the catalyzed reaction as one that follows the formation of 4-CB-CoA (viz.	4-chlorobenzoyl coenzyme A	147-155	Cbl proto-oncogene	Homo sapiens	46-49
18235045-5	2008	Lyn also negatively regulates c-Cbl stability, whereas c-Cbl tyrosine phosphorylation is mediated by BCR-ABL.	Tyrosine	61-69	Cbl proto-oncogene	Homo sapiens	55-60
18662810-3	2008	Binding specificity of CBL was investigated by enzyme-linked lectin-sorbent assay using a series of simple sugars, polysaccharides, and glycoproteins.	Sugars	107-113	Cbl proto-oncogene	Homo sapiens	23-26
18662810-5	2008	CBL showed maximum affinity for human tumor-associated Tn-antigens (GalNAcalpha1-Ser/Thr) at the molecular level and was 3.5 times higher than GalNAc.	Serine	81-84	Cbl proto-oncogene	Homo sapiens	0-3
18662810-5	2008	CBL showed maximum affinity for human tumor-associated Tn-antigens (GalNAcalpha1-Ser/Thr) at the molecular level and was 3.5 times higher than GalNAc.	Threonine	85-88	Cbl proto-oncogene	Homo sapiens	0-3
18662810-5	2008	CBL showed maximum affinity for human tumor-associated Tn-antigens (GalNAcalpha1-Ser/Thr) at the molecular level and was 3.5 times higher than GalNAc.	N-acetylgalactosaminuronic acid	68-74	Cbl proto-oncogene	Homo sapiens	0-3
18662810-7	2008	The overall specificity of CBL lies in the order of polyvalent Tn, Talpha and II&gt;&gt;&gt;&gt;monovalent Tn &gt; or = Me-alphaGalNAc&gt;monovalent Talpha&gt; Me-betaGalNAc&gt;Me-alphaGal&gt;monovalent T&gt;GalNAc&gt;monovalent F&gt;monovalent II&gt;Me-betaGal&gt;Gal.	talpha	67-73	Cbl proto-oncogene	Homo sapiens	27-30
18662810-7	2008	The overall specificity of CBL lies in the order of polyvalent Tn, Talpha and II&gt;&gt;&gt;&gt;monovalent Tn &gt; or = Me-alphaGalNAc&gt;monovalent Talpha&gt; Me-betaGalNAc&gt;Me-alphaGal&gt;monovalent T&gt;GalNAc&gt;monovalent F&gt;monovalent II&gt;Me-betaGal&gt;Gal.	betagalnac	163-173	Cbl proto-oncogene	Homo sapiens	27-30
18662810-7	2008	The overall specificity of CBL lies in the order of polyvalent Tn, Talpha and II&gt;&gt;&gt;&gt;monovalent Tn &gt; or = Me-alphaGalNAc&gt;monovalent Talpha&gt; Me-betaGalNAc&gt;Me-alphaGal&gt;monovalent T&gt;GalNAc&gt;monovalent F&gt;monovalent II&gt;Me-betaGal&gt;Gal.	N-acetylgalactosaminuronic acid	128-134	Cbl proto-oncogene	Homo sapiens	27-30
18632619-9	2008	Taken together, our results show that c-Cbl constitutes a new ligase responsible for the ubiquitination of IGF-IR and that it complements the action of Mdm2 on ubiquitin lysine residue specificity, responsiveness to IGF-I, and type of endocytic pathway used.	Lysine	170-176	Cbl proto-oncogene	Homo sapiens	38-43
18577747-11	2008	Unique LYN phosphorylation sites (tyrosine-193 and tyrosine-459) and associated proteins (c-Cbl and p80) were identified in cells from imatinib-resistant patients.	Imatinib Mesylate	135-143	Cbl proto-oncogene	Homo sapiens	90-95
18235045-3	2008	In imatinib-resistant CML cells and patients, Lyn activation is BCR-ABL independent, it is complexed with the Gab2 and c-Cbl adapter/scaffold proteins, and it mediates persistent Gab2 and BCR-ABL tyrosine phosphorylation in the presence or absence of imatinib.	Imatinib Mesylate	3-11	Cbl proto-oncogene	Homo sapiens	119-124
18237745-2	2008	Calcineurin B-like (CBL) proteins and their target kinases, CBL-interacting protein kinases (CIPKs), represent important relays in plant calcium signaling.	Calcium	137-144	Cbl proto-oncogene	Homo sapiens	20-23
18237745-2	2008	Calcineurin B-like (CBL) proteins and their target kinases, CBL-interacting protein kinases (CIPKs), represent important relays in plant calcium signaling.	Calcium	137-144	Cbl proto-oncogene	Homo sapiens	60-63
18273061-3	2008	An obligatory, intrapeptidyl H-bond between the phosphotyrosine and the conserved asparagine or adjacent arginine is essential for binding and orients the peptide into a positively charged pocket on c-Cbl.	Phosphotyrosine	48-63	Cbl proto-oncogene	Homo sapiens	199-204
18322233-5	2008	These studies demonstrated that aggregation of leukocyte Ig-like receptor LILRA-2 resulted in phosphorylation of Syk and c-Cbl, was inhibited by a third generation Syk inhibitor with an expected IC(50), and induced histamine release in strict proportion to release induced by anti-IgE Ab.	Histamine	215-224	Cbl proto-oncogene	Homo sapiens	121-126
18273061-3	2008	An obligatory, intrapeptidyl H-bond between the phosphotyrosine and the conserved asparagine or adjacent arginine is essential for binding and orients the peptide into a positively charged pocket on c-Cbl.	Asparagine	82-92	Cbl proto-oncogene	Homo sapiens	199-204
18273061-3	2008	An obligatory, intrapeptidyl H-bond between the phosphotyrosine and the conserved asparagine or adjacent arginine is essential for binding and orients the peptide into a positively charged pocket on c-Cbl.	Arginine	105-113	Cbl proto-oncogene	Homo sapiens	199-204
18164258-0	2008	Up-regulation of the Cbl family of ubiquitin ligases is involved in ATRA and bufalin-induced cell adhesion but not cell differentiation.	bufalin	77-84	Cbl proto-oncogene	Homo sapiens	21-24
17971399-1	2008	Exposure to hydrogen peroxide (H2O2), one of the reactive oxidants in the gas phase of cigarette smoke (CS), induces aberrant phosphorylation of the epidermal growth factor receptor (EGFR), resulting in the lack of ubiquitination by c-Cbl, and impaired degradation.	Hydrogen Peroxide	12-29	Cbl proto-oncogene	Homo sapiens	233-238
17971399-1	2008	Exposure to hydrogen peroxide (H2O2), one of the reactive oxidants in the gas phase of cigarette smoke (CS), induces aberrant phosphorylation of the epidermal growth factor receptor (EGFR), resulting in the lack of ubiquitination by c-Cbl, and impaired degradation.	Hydrogen Peroxide	31-35	Cbl proto-oncogene	Homo sapiens	233-238
17971399-1	2008	Exposure to hydrogen peroxide (H2O2), one of the reactive oxidants in the gas phase of cigarette smoke (CS), induces aberrant phosphorylation of the epidermal growth factor receptor (EGFR), resulting in the lack of ubiquitination by c-Cbl, and impaired degradation.	Cesium	104-106	Cbl proto-oncogene	Homo sapiens	233-238
17971399-4	2008	We found that exposure of human airway epithelial cells to CS, as with exposure to H2O2, not only results in an increase in EGFR activation over time, but the EGFR activated by H2O2 or CS is neither ubiquitinated nor subsequently degraded due to its inability to bind the E3 ubiquitin ligase, c-Cbl, either directly or indirectly via the Grb2 adapter protein.	Cesium	59-61	Cbl proto-oncogene	Homo sapiens	293-298
17971399-4	2008	We found that exposure of human airway epithelial cells to CS, as with exposure to H2O2, not only results in an increase in EGFR activation over time, but the EGFR activated by H2O2 or CS is neither ubiquitinated nor subsequently degraded due to its inability to bind the E3 ubiquitin ligase, c-Cbl, either directly or indirectly via the Grb2 adapter protein.	Hydrogen Peroxide	83-87	Cbl proto-oncogene	Homo sapiens	293-298
17971399-4	2008	We found that exposure of human airway epithelial cells to CS, as with exposure to H2O2, not only results in an increase in EGFR activation over time, but the EGFR activated by H2O2 or CS is neither ubiquitinated nor subsequently degraded due to its inability to bind the E3 ubiquitin ligase, c-Cbl, either directly or indirectly via the Grb2 adapter protein.	Hydrogen Peroxide	177-181	Cbl proto-oncogene	Homo sapiens	293-298
18164258-2	2008	It has been reported that c-Cbl and Cbl-b mRNAs are up-regulated during TPA-induced U937 and HL-60 cell differentiation.	Tetradecanoylphorbol Acetate	72-75	Cbl proto-oncogene	Homo sapiens	26-31
18164258-4	2008	In the present study, we demonstrated that bufalin enhanced all-trans retinoic acid (ATRA) induced differentiation of HL-60 cells, accompanied by up-regulation of the Cbl family of ubiquitin ligases.	bufalin	43-50	Cbl proto-oncogene	Homo sapiens	167-170
18164258-9	2008	These results suggested that up-regulation of c-Cbl and Cbl-b was involved in the regulation of ATRA and bufalin-induced HL-60 cell adhesion rather than cell differentiation, which might be mediated by lipid raft localization, ubiquitin ligase activity and C-terminal structure of Cbl proteins.	bufalin	105-112	Cbl proto-oncogene	Homo sapiens	46-51
18164258-9	2008	These results suggested that up-regulation of c-Cbl and Cbl-b was involved in the regulation of ATRA and bufalin-induced HL-60 cell adhesion rather than cell differentiation, which might be mediated by lipid raft localization, ubiquitin ligase activity and C-terminal structure of Cbl proteins.	bufalin	105-112	Cbl proto-oncogene	Homo sapiens	48-51
18062779-4	2008	Here, we show, using CD33/sialic acid-binding immunoglobulin-like lectin (Siglec)-3 as a paradigm, that ITIMs can bind to the ubiquitin ligase Cbl and that ITIMs are ubiquitylated following Src family kinase-mediated tyrosine phosphorylation.	Tyrosine	217-225	Cbl proto-oncogene	Homo sapiens	143-146
17255109-8	2007	c-Cbl and PP2A-A compete for binding centered around Tyr-55 on Spry2.	Tyrosine	53-56	Cbl proto-oncogene	Homo sapiens	0-5
17620338-4	2007	Here, we demonstrate that endogenous Cbl is essential for ligand-induced ubiquitinylation and degradation of PDGFRbeta; this involves the Cbl TKB domain binding to PDGFRbeta phosphotyrosine 1021, a known phospholipase C (PLC) gamma1 SH2 domain-binding site.	Phosphotyrosine	174-189	Cbl proto-oncogene	Homo sapiens	37-40
17620338-4	2007	Here, we demonstrate that endogenous Cbl is essential for ligand-induced ubiquitinylation and degradation of PDGFRbeta; this involves the Cbl TKB domain binding to PDGFRbeta phosphotyrosine 1021, a known phospholipase C (PLC) gamma1 SH2 domain-binding site.	Phosphotyrosine	174-189	Cbl proto-oncogene	Homo sapiens	138-141
17635922-0	2007	Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase.	UBP 310	21-24	Cbl proto-oncogene	Homo sapiens	50-55
17635922-2	2007	Cbl proteins bind to phosphotyrosine residues on activated RTKs to affect ligand-dependent ubiquitylation of these receptors targeting them for degradation in the lysosome.	Phosphotyrosine	21-36	Cbl proto-oncogene	Homo sapiens	0-3
17635922-3	2007	Both c-Cbl and Cbl-b contain a ubiquitin-associated (UBA) domain, which is important for Cbl dimerization and tyrosine phosphorylation; however, the mechanism of UBA-mediated dimerization and its requirement for Cbl biological activity is unclear.	Tyrosine	110-118	Cbl proto-oncogene	Homo sapiens	5-10
17635922-3	2007	Both c-Cbl and Cbl-b contain a ubiquitin-associated (UBA) domain, which is important for Cbl dimerization and tyrosine phosphorylation; however, the mechanism of UBA-mediated dimerization and its requirement for Cbl biological activity is unclear.	Tyrosine	110-118	Cbl proto-oncogene	Homo sapiens	7-10
17635922-3	2007	Both c-Cbl and Cbl-b contain a ubiquitin-associated (UBA) domain, which is important for Cbl dimerization and tyrosine phosphorylation; however, the mechanism of UBA-mediated dimerization and its requirement for Cbl biological activity is unclear.	Tyrosine	110-118	Cbl proto-oncogene	Homo sapiens	15-18
17635922-3	2007	Both c-Cbl and Cbl-b contain a ubiquitin-associated (UBA) domain, which is important for Cbl dimerization and tyrosine phosphorylation; however, the mechanism of UBA-mediated dimerization and its requirement for Cbl biological activity is unclear.	UBP 310	53-56	Cbl proto-oncogene	Homo sapiens	5-10
17635922-3	2007	Both c-Cbl and Cbl-b contain a ubiquitin-associated (UBA) domain, which is important for Cbl dimerization and tyrosine phosphorylation; however, the mechanism of UBA-mediated dimerization and its requirement for Cbl biological activity is unclear.	UBP 310	53-56	Cbl proto-oncogene	Homo sapiens	7-10
17635922-3	2007	Both c-Cbl and Cbl-b contain a ubiquitin-associated (UBA) domain, which is important for Cbl dimerization and tyrosine phosphorylation; however, the mechanism of UBA-mediated dimerization and its requirement for Cbl biological activity is unclear.	UBP 310	53-56	Cbl proto-oncogene	Homo sapiens	15-18
17691815-6	2007	Our results also reveal that the secondary structural stability of the c-Cbl RING domain is mainly determined by the hydrogen-bonding networks in or near the two zinc ion binding sites.	Hydrogen	117-125	Cbl proto-oncogene	Homo sapiens	71-76
17372230-4	2007	Site-directed mutagenesis of VEGFR-2 showed that full activation of c-Cbl requires its direct association with phospho-tyrosines 1052 and 1057 of VEGFR-2 via its TKB domain and indirect association with phospho-tyrosine 1173 of VEGFR-2 via PLCgamma1.	Tyrosine	119-128	Cbl proto-oncogene	Homo sapiens	68-73
17372230-4	2007	Site-directed mutagenesis of VEGFR-2 showed that full activation of c-Cbl requires its direct association with phospho-tyrosines 1052 and 1057 of VEGFR-2 via its TKB domain and indirect association with phospho-tyrosine 1173 of VEGFR-2 via PLCgamma1.	Dihydroxyacetone Phosphate	111-118	Cbl proto-oncogene	Homo sapiens	68-73
17372230-4	2007	Site-directed mutagenesis of VEGFR-2 showed that full activation of c-Cbl requires its direct association with phospho-tyrosines 1052 and 1057 of VEGFR-2 via its TKB domain and indirect association with phospho-tyrosine 1173 of VEGFR-2 via PLCgamma1.	Tyrosine	119-127	Cbl proto-oncogene	Homo sapiens	68-73
17372230-5	2007	The tertiary complex formation between VEGFR-2, PLCgamma1 and c-Cbl selectively promotes ubiquitylation and suppression of tyrosine phosphorylation of PLCgamma1 by a proteolysis-independent mechanism.	Tyrosine	123-131	Cbl proto-oncogene	Homo sapiens	62-67
18540842-1	2008	The uptake of vitamin B12 (cyanocobalamin, Cbl/VB12) in mammalian cells is mediated by specific, high-affinity receptors for the vitamin B12-binding protein, transcobalamin II, which is expressed on the plasma membrane.	Vitamin B 12	14-25	Cbl proto-oncogene	Homo sapiens	43-46
18027984-5	2007	This study, which focuses on the 4-chlorobenzoate:CoA ligase (CBL) of the 4-monochlorobiphenyl degrading bacterium Alcaligenes sp.	4-chlorobenzoic acid	33-49	Cbl proto-oncogene	Homo sapiens	62-65
18027984-5	2007	This study, which focuses on the 4-chlorobenzoate:CoA ligase (CBL) of the 4-monochlorobiphenyl degrading bacterium Alcaligenes sp.	3-chlorobiphenyl	76-94	Cbl proto-oncogene	Homo sapiens	62-65
18027984-10	2007	The structural basis for the approximately 100-fold enhancement in the rate of 3,4-dichlorobenzoate thioesterification catalyzed by the I303A and I303G CBL mutants was validated by determination of the crystal structure of the 3,4-dichlorobenzoate-bound enzymes.	3,4-dichlorobenzoate	79-99	Cbl proto-oncogene	Homo sapiens	152-155
18027984-10	2007	The structural basis for the approximately 100-fold enhancement in the rate of 3,4-dichlorobenzoate thioesterification catalyzed by the I303A and I303G CBL mutants was validated by determination of the crystal structure of the 3,4-dichlorobenzoate-bound enzymes.	3,4-dichlorobenzoate	227-247	Cbl proto-oncogene	Homo sapiens	152-155
18027984-12	2007	The C(4)Cl pocket of the CBL I303A mutant was then reduced in size by strategic amino acid replacement.	c(4)cl	4-10	Cbl proto-oncogene	Homo sapiens	25-28
18074035-1	2007	BACKGROUND: Nitrosylcobalamin (NO-Cbl) is a chemotherapeutic pro-drug derived from vitamin B12 that preferentially delivers nitric oxide (NO) to tumor cells, based upon increased receptor expression.	nitrosylcobalamin	12-29	Cbl proto-oncogene	Homo sapiens	34-37
18074035-1	2007	BACKGROUND: Nitrosylcobalamin (NO-Cbl) is a chemotherapeutic pro-drug derived from vitamin B12 that preferentially delivers nitric oxide (NO) to tumor cells, based upon increased receptor expression.	Vitamin B 12	83-94	Cbl proto-oncogene	Homo sapiens	34-37
18074035-1	2007	BACKGROUND: Nitrosylcobalamin (NO-Cbl) is a chemotherapeutic pro-drug derived from vitamin B12 that preferentially delivers nitric oxide (NO) to tumor cells, based upon increased receptor expression.	Nitric Oxide	124-136	Cbl proto-oncogene	Homo sapiens	34-37
17922773-10	2007	In support of the conclusion that CBL1 and CBL9 interact with and synergistically serve as upstream regulators of CIPK23, the cbl1 cbl9 double mutant, but not the cbl1 or cbl9 single mutants, exhibit altered phenotypes for stomatal responses and low-potassium sensitivity.	Potassium	250-259	Cbl proto-oncogene	Homo sapiens	126-135
17530754-9	2007	The excited-state spectrum of methyl, ethyl, and n-propylcobalamin is characteristic of a Cbl(III) species with a sigma-donating alkyl anion ligand (Type II).	methyl, ethyl, and n-propylcobalamin	30-66	Cbl proto-oncogene	Homo sapiens	90-93
17530754-11	2007	The results are discussed in the context of theoretical calculations of Cbl(III) species reported in the literature and highlight the need for additional calculations exploring the influence of the alkyl ligand on the electronic structure of cobalamins.	Vitamin B 12	242-252	Cbl proto-oncogene	Homo sapiens	72-75
17237826-0	2007	c-Cbl-facilitated cytoskeletal effects in v-Abl-transformed fibroblasts are regulated by membrane association of c-Cbl.	lauric acid	44-47	Cbl proto-oncogene	Homo sapiens	0-5
17237826-0	2007	c-Cbl-facilitated cytoskeletal effects in v-Abl-transformed fibroblasts are regulated by membrane association of c-Cbl.	lauric acid	44-47	Cbl proto-oncogene	Homo sapiens	113-118
17237826-4	2007	Our studies indicate that localization of c-Cbl to the membrane is likely to be mediated by the tyrosine kinase binding (TKB) domain and the proline-rich region of c-Cbl, whereas C-terminal tyrosine phosphorylation does not play a role.	Proline	141-148	Cbl proto-oncogene	Homo sapiens	42-47
17237826-4	2007	Our studies indicate that localization of c-Cbl to the membrane is likely to be mediated by the tyrosine kinase binding (TKB) domain and the proline-rich region of c-Cbl, whereas C-terminal tyrosine phosphorylation does not play a role.	Tyrosine	96-104	Cbl proto-oncogene	Homo sapiens	42-47
17237826-6	2007	Our studies further demonstrate that Src-like adaptor protein (SLAP), which binds to v-Cbl in a tyrosine phosphorylation-independent manner, facilitates membrane association of Cbl.	Tyrosine	96-104	Cbl proto-oncogene	Homo sapiens	177-180
17449471-4	2007	Cbl can directly bind cMet at phosphotyrosine 1003 or indirectly via Grb2 to phosphotyrosine 1356 in the multisubstrate binding domain of cMet.	Phosphotyrosine	30-45	Cbl proto-oncogene	Homo sapiens	0-3
17449471-4	2007	Cbl can directly bind cMet at phosphotyrosine 1003 or indirectly via Grb2 to phosphotyrosine 1356 in the multisubstrate binding domain of cMet.	Phosphotyrosine	77-92	Cbl proto-oncogene	Homo sapiens	0-3
17454001-4	2007	Analysis of amino acid sequence revealed conserved residues of cysteine, histidine, asparagine, occluding loop pattern, hemoglobinase motif and glutamine of the oxyanion hole characteristic of cathepsin B like proteases (CBL).	Cysteine	63-71	Cbl proto-oncogene	Homo sapiens	193-219
17454001-4	2007	Analysis of amino acid sequence revealed conserved residues of cysteine, histidine, asparagine, occluding loop pattern, hemoglobinase motif and glutamine of the oxyanion hole characteristic of cathepsin B like proteases (CBL).	Histidine	73-82	Cbl proto-oncogene	Homo sapiens	193-219
17454001-4	2007	Analysis of amino acid sequence revealed conserved residues of cysteine, histidine, asparagine, occluding loop pattern, hemoglobinase motif and glutamine of the oxyanion hole characteristic of cathepsin B like proteases (CBL).	Asparagine	84-94	Cbl proto-oncogene	Homo sapiens	193-219
17454001-4	2007	Analysis of amino acid sequence revealed conserved residues of cysteine, histidine, asparagine, occluding loop pattern, hemoglobinase motif and glutamine of the oxyanion hole characteristic of cathepsin B like proteases (CBL).	Glutamine	144-153	Cbl proto-oncogene	Homo sapiens	193-219
17454001-6	2007	Phylogenetic analysis revealed close evolutionary proximity of the protein sequence to counterpart sequences in the CBL, suggesting that HC58cDNA was a member of the papain family.	hc58cdna	137-145	Cbl proto-oncogene	Homo sapiens	116-119
17347267-1	2007	Cells that are metabolically active and in a high degree of differentiation and proliferation require cobalamin (Cbl: vitamin B(12)) and they obtain it from the circulation bound to transcobalamin (TC) via the transcobalamin receptor (TC-R).	Vitamin B 12	102-111	Cbl proto-oncogene	Homo sapiens	113-116
17487979-1	2007	Three proteins, intrinsic factor (IF), transcobalamin (TC), and haptocorrin (HC), all have an extremely high affinity for the cobalamins (Cbls, Kd approximately 5 fM) but discriminate these physiological ligands from Cbl analogues with different efficiencies decreasing in the following order: IF &gt; TC &gt; HC.	Vitamin B 12	126-136	Cbl proto-oncogene	Homo sapiens	138-141
17255109-10	2007	c-Cbl binding likely targets Spry2 for ubiquitin-linked destruction, whereas the phosphatase binding and activity are necessary to dephosphorylate specific Ser/Thr residues.	Serine	156-159	Cbl proto-oncogene	Homo sapiens	0-5
17255109-10	2007	c-Cbl binding likely targets Spry2 for ubiquitin-linked destruction, whereas the phosphatase binding and activity are necessary to dephosphorylate specific Ser/Thr residues.	Threonine	160-163	Cbl proto-oncogene	Homo sapiens	0-5
16906159-4	2006	In T cells, the SH2 domain of GRB2 binds phosphorylated tyrosines on the adaptor protein LAT and the GRB2 SH3 domains associate with the proline-rich regions of SOS1 and CBL.	Proline	137-144	Cbl proto-oncogene	Homo sapiens	170-173
17011224-1	2007	Inborn errors of vitamin B12 (cobalamin, Cbl) metabolism are autosomal recessive disorders and have been classified into nine distinct complementation classes (cblA-cblH and mut).	Vitamin B 12	17-28	Cbl proto-oncogene	Homo sapiens	41-44
17094785-4	2006	Mutating prolines 543-548 reduced Src binding to the Cbl 479-636 fragment significantly more than mutating the prolines in the PPVPPR(494-499) motif, which was previously reported to bind Src SH3.	Proline	9-17	Cbl proto-oncogene	Homo sapiens	53-56
17094785-5	2006	Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src-induced phosphorylation of Cbl, and the inhibition of Src kinase activity by Cbl.	Proline	13-21	Cbl proto-oncogene	Homo sapiens	9-12
17094785-5	2006	Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src-induced phosphorylation of Cbl, and the inhibition of Src kinase activity by Cbl.	Proline	13-21	Cbl proto-oncogene	Homo sapiens	79-82
17094785-5	2006	Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src-induced phosphorylation of Cbl, and the inhibition of Src kinase activity by Cbl.	Proline	13-21	Cbl proto-oncogene	Homo sapiens	79-82
17094785-5	2006	Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src-induced phosphorylation of Cbl, and the inhibition of Src kinase activity by Cbl.	Proline	13-21	Cbl proto-oncogene	Homo sapiens	79-82
17094785-5	2006	Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src-induced phosphorylation of Cbl, and the inhibition of Src kinase activity by Cbl.	Alanine	33-41	Cbl proto-oncogene	Homo sapiens	9-12
17094785-5	2006	Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src-induced phosphorylation of Cbl, and the inhibition of Src kinase activity by Cbl.	Alanine	33-41	Cbl proto-oncogene	Homo sapiens	79-82
17094785-5	2006	Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src-induced phosphorylation of Cbl, and the inhibition of Src kinase activity by Cbl.	Alanine	33-41	Cbl proto-oncogene	Homo sapiens	79-82
17094785-5	2006	Mutating Cbl prolines 543-548 to alanines substantially reduced Src binding to Cbl, Src-induced phosphorylation of Cbl, and the inhibition of Src kinase activity by Cbl.	Alanine	33-41	Cbl proto-oncogene	Homo sapiens	79-82
17094785-7	2006	In contrast, disabling the tyrosine kinase-binding domain of full-length Cbl by mutating glycine 306 to glutamic acid, and thereby preventing the previously described binding of the tyrosine kinase-binding domain to the Src phosphotyrosine 416, had no effect on Cbl phosphorylation, the inhibition of Src activity by full-length Cbl, or bone resorption.	Phosphotyrosine	224-239	Cbl proto-oncogene	Homo sapiens	73-76
17105231-11	2006	The dissociation of cyanocobalamin (CN-Cbl) adducts of biotin-serine-O-methyl ether, biotin-aminobutyric acid, and biotin-valine were compared with the CN-Cbl adduct of biotin-sarcosine.	biotin-serine-o-methyl ether	55-83	Cbl proto-oncogene	Homo sapiens	39-42
17105231-11	2006	The dissociation of cyanocobalamin (CN-Cbl) adducts of biotin-serine-O-methyl ether, biotin-aminobutyric acid, and biotin-valine were compared with the CN-Cbl adduct of biotin-sarcosine.	biotin-aminobutyric acid	85-109	Cbl proto-oncogene	Homo sapiens	39-42
17105231-11	2006	The dissociation of cyanocobalamin (CN-Cbl) adducts of biotin-serine-O-methyl ether, biotin-aminobutyric acid, and biotin-valine were compared with the CN-Cbl adduct of biotin-sarcosine.	biotin-valine	115-128	Cbl proto-oncogene	Homo sapiens	39-42
16780420-4	2006	We demonstrate that phosphorylated Tyr568 and Tyr936 in c-Kit are involved in direct binding and activation of Cbl and that binding of the TKB domain (tyrosine kinase binding domain) of Cbl to c-Kit is specified by the presence of an isoleucine or leucine residue in position +3 to the phosphorylated tyrosine residue on c-Kit.	Isoleucine	234-244	Cbl proto-oncogene	Homo sapiens	111-114
16780420-4	2006	We demonstrate that phosphorylated Tyr568 and Tyr936 in c-Kit are involved in direct binding and activation of Cbl and that binding of the TKB domain (tyrosine kinase binding domain) of Cbl to c-Kit is specified by the presence of an isoleucine or leucine residue in position +3 to the phosphorylated tyrosine residue on c-Kit.	Isoleucine	234-244	Cbl proto-oncogene	Homo sapiens	186-189
16780420-4	2006	We demonstrate that phosphorylated Tyr568 and Tyr936 in c-Kit are involved in direct binding and activation of Cbl and that binding of the TKB domain (tyrosine kinase binding domain) of Cbl to c-Kit is specified by the presence of an isoleucine or leucine residue in position +3 to the phosphorylated tyrosine residue on c-Kit.	Leucine	237-244	Cbl proto-oncogene	Homo sapiens	111-114
16780420-4	2006	We demonstrate that phosphorylated Tyr568 and Tyr936 in c-Kit are involved in direct binding and activation of Cbl and that binding of the TKB domain (tyrosine kinase binding domain) of Cbl to c-Kit is specified by the presence of an isoleucine or leucine residue in position +3 to the phosphorylated tyrosine residue on c-Kit.	Leucine	237-244	Cbl proto-oncogene	Homo sapiens	186-189
16780420-4	2006	We demonstrate that phosphorylated Tyr568 and Tyr936 in c-Kit are involved in direct binding and activation of Cbl and that binding of the TKB domain (tyrosine kinase binding domain) of Cbl to c-Kit is specified by the presence of an isoleucine or leucine residue in position +3 to the phosphorylated tyrosine residue on c-Kit.	Tyrosine	151-159	Cbl proto-oncogene	Homo sapiens	186-189
16969069-3	2006	The interaction between EGFR and c-Cbl has been shown to depend upon receptor phosphorylation at tyrosine residue 1045, the major docking site for c-Cbl.	Tyrosine	97-105	Cbl proto-oncogene	Homo sapiens	33-38
16969069-3	2006	The interaction between EGFR and c-Cbl has been shown to depend upon receptor phosphorylation at tyrosine residue 1045, the major docking site for c-Cbl.	Tyrosine	97-105	Cbl proto-oncogene	Homo sapiens	147-152
16969069-8	2006	These results suggest that hypophosphorylation of tyrosine residue 1045 is likely to be the cause for EGFRvIII escape from c-Cbl-induced ubiquitination and degradation, enhancing EGFRvIII"s ability to increase proliferation in breast cancer cells.	Tyrosine	50-58	Cbl proto-oncogene	Homo sapiens	123-128
16969069-9	2006	Interestingly, inefficient degradation was only observed in the gefitinib resistant EGFR kinase mutant, despite the fact that this mutant receptor is capable of recruiting c-Cbl and undergoes ubiquitination.	Gefitinib	64-73	Cbl proto-oncogene	Homo sapiens	172-177
17094785-2	2006	We previously showed that the primary interaction between Src and Cbl is mediated by the Src homology domain 3 (SH3) of Src binding to proline-rich sequences of Cbl.	Proline	135-142	Cbl proto-oncogene	Homo sapiens	66-69
17094785-2	2006	We previously showed that the primary interaction between Src and Cbl is mediated by the Src homology domain 3 (SH3) of Src binding to proline-rich sequences of Cbl.	Proline	135-142	Cbl proto-oncogene	Homo sapiens	161-164
16928382-5	2006	Furthermore, Cbl displayed a substantial increase in both levels of expression and tyrosine phosphorylation in 48 h PO myocardium.	Tyrosine	83-91	Cbl proto-oncogene	Homo sapiens	13-16
16961380-1	2006	The reaction between aquacobalamin, Cbl(H2O), and NO was studied at low pH.	Water	40-43	Cbl proto-oncogene	Homo sapiens	36-39
16961380-2	2006	As previously reported, the final product of the reaction is the same as that obtained in the reaction of NO and reduced Cbl(H2O), viz.	Water	125-128	Cbl proto-oncogene	Homo sapiens	121-124
16961380-5	2006	Kinetic and UV-vis spectroscopic data show that Cbl(NO2-) is generated during this reaction.	Nitrogen Dioxide	52-55	Cbl proto-oncogene	Homo sapiens	48-51
16961380-11	2006	The reductive nitrosylation reaction is practically dominated by a back reaction, i.e., the reaction between Cbl(NO-) and HNO2, which accounts for the strange NO and HNO2 concentration dependencies observed.	Nitrous Acid	122-126	Cbl proto-oncogene	Homo sapiens	109-112
16961380-11	2006	The reductive nitrosylation reaction is practically dominated by a back reaction, i.e., the reaction between Cbl(NO-) and HNO2, which accounts for the strange NO and HNO2 concentration dependencies observed.	Nitrous Acid	166-170	Cbl proto-oncogene	Homo sapiens	109-112
16289966-0	2006	Activation of Epstein-Barr virus/C3d receptor (gp140, CR2, CD21) on human B lymphoma cell surface triggers Cbl tyrosine phosphorylation, its association with p85 subunit, Crk-L and Syk and its dissociation with Vav.	Tyrosine	111-119	Cbl proto-oncogene	Homo sapiens	107-110
16289966-7	2006	Second, once tyrosine phosphorylated, Cbl interacts with SH2 domains of p85 subunit, SH2 domains of Crk-L and with tyrosine phosphorylated Syk kinase.	Tyrosine	115-123	Cbl proto-oncogene	Homo sapiens	38-41
16289966-5	2006	First, CD21 activation triggered Cbl tyrosine phosphorylation, which required c-Src kinase but not PI 3-kinase or Syk kinase activities.	Tyrosine	37-45	Cbl proto-oncogene	Homo sapiens	33-36
16289966-7	2006	Second, once tyrosine phosphorylated, Cbl interacts with SH2 domains of p85 subunit, SH2 domains of Crk-L and with tyrosine phosphorylated Syk kinase.	Tyrosine	13-21	Cbl proto-oncogene	Homo sapiens	38-41
16847314-1	2006	We have previously demonstrated that nitrosylcobalamin (NO-Cbl), an analogue of vitamin B12 that delivers nitric oxide (NO), had potent antiproliferative activity against several human cancer cell lines.	nitrosylcobalamin	37-54	Cbl proto-oncogene	Homo sapiens	59-62
16847314-1	2006	We have previously demonstrated that nitrosylcobalamin (NO-Cbl), an analogue of vitamin B12 that delivers nitric oxide (NO), had potent antiproliferative activity against several human cancer cell lines.	Vitamin B 12	80-91	Cbl proto-oncogene	Homo sapiens	59-62
16847314-1	2006	We have previously demonstrated that nitrosylcobalamin (NO-Cbl), an analogue of vitamin B12 that delivers nitric oxide (NO), had potent antiproliferative activity against several human cancer cell lines.	Nitric Oxide	106-118	Cbl proto-oncogene	Homo sapiens	59-62
16847314-12	2006	Thus, DR4 residue C336 becomes S nitrosylated and promotes apoptosis following NO-Cbl treatment.	c336	18-22	Cbl proto-oncogene	Homo sapiens	82-85
18404481-2	2006	Engagement of CD38 by agonistic monoclonal antibodies and the CD31 ligand initiates a cytoplasmic signaling cascade involving tyrosine phosphorylation of the proto-oncogene c-cbl and of the extracellular regulated kinase 1 of 2 complex.	Tyrosine	126-134	Cbl proto-oncogene	Homo sapiens	158-178
16407834-3	2006	Here we show that the SH3 domain of betaPix specifically interacts with a proline-arginine motif (PxxxPR) present within the ubiquitin ligase Cbl and Pak1 kinase.	Proline	74-81	Cbl proto-oncogene	Homo sapiens	142-145
16407834-3	2006	Here we show that the SH3 domain of betaPix specifically interacts with a proline-arginine motif (PxxxPR) present within the ubiquitin ligase Cbl and Pak1 kinase.	Arginine	82-90	Cbl proto-oncogene	Homo sapiens	142-145
16798838-9	2006	The CXCL8-induced phosphorylation of Cbl was also reduced when cells were pre-treated with the PI3K inhibitor LY294002.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	Cbl proto-oncogene	Homo sapiens	37-40
16858728-7	2006	Furthermore, proteins, such as SHIP-1, SH2-containing protein (SHC) and Casitas B-lineage lymphoma proto-oncogene (CBL), are also regulated by Imatinib.	Imatinib Mesylate	143-151	Cbl proto-oncogene	Homo sapiens	72-113
16858728-7	2006	Furthermore, proteins, such as SHIP-1, SH2-containing protein (SHC) and Casitas B-lineage lymphoma proto-oncogene (CBL), are also regulated by Imatinib.	Imatinib Mesylate	143-151	Cbl proto-oncogene	Homo sapiens	115-118
16834388-1	2006	The 4-coordinate, low-spin cob(I)alamin (Co1+Cbl) species, which can be obtained by heterolytic cleavage of the Co-C bond in methylcobalamin or the two-electron reduction of vitamin B12, is one of the most powerful nucleophiles known to date.	Vitamin B 12	27-39	Cbl proto-oncogene	Homo sapiens	45-48
16834388-1	2006	The 4-coordinate, low-spin cob(I)alamin (Co1+Cbl) species, which can be obtained by heterolytic cleavage of the Co-C bond in methylcobalamin or the two-electron reduction of vitamin B12, is one of the most powerful nucleophiles known to date.	Cobalt	41-43	Cbl proto-oncogene	Homo sapiens	45-48
16834388-1	2006	The 4-coordinate, low-spin cob(I)alamin (Co1+Cbl) species, which can be obtained by heterolytic cleavage of the Co-C bond in methylcobalamin or the two-electron reduction of vitamin B12, is one of the most powerful nucleophiles known to date.	Carbon	41-42	Cbl proto-oncogene	Homo sapiens	45-48
16834388-1	2006	The 4-coordinate, low-spin cob(I)alamin (Co1+Cbl) species, which can be obtained by heterolytic cleavage of the Co-C bond in methylcobalamin or the two-electron reduction of vitamin B12, is one of the most powerful nucleophiles known to date.	mecobalamin	125-140	Cbl proto-oncogene	Homo sapiens	45-48
16834388-1	2006	The 4-coordinate, low-spin cob(I)alamin (Co1+Cbl) species, which can be obtained by heterolytic cleavage of the Co-C bond in methylcobalamin or the two-electron reduction of vitamin B12, is one of the most powerful nucleophiles known to date.	Vitamin B 12	174-185	Cbl proto-oncogene	Homo sapiens	45-48
16834388-5	2006	Collectively, our results indicate that the supernucleophilicity of Co1+Cbl can be attributed to the large destabilization of the Co 3dz2-based HOMO and its favorable orientation with respect to the corrin macrocycle, which minimizes steric repulsion during nucleophilic attack.	corrin	199-205	Cbl proto-oncogene	Homo sapiens	72-75
16455755-10	2006	Such translocation temporally matches the insulin-stimulated movement of Cbl and CrkII in flotillin-1/GLUT4-containing domains, as well as the activation of the GDP-GTP exchange factor C3G.	gdp-gtp	161-168	Cbl proto-oncogene	Homo sapiens	73-76
16474167-6	2006	The PHD of FANCL also shares sequence similarity to the canonical RING finger of c-CBL, including a conserved tryptophan required for E2 binding by c-CBL.	Tryptophan	110-120	Cbl proto-oncogene	Homo sapiens	81-86
16474167-6	2006	The PHD of FANCL also shares sequence similarity to the canonical RING finger of c-CBL, including a conserved tryptophan required for E2 binding by c-CBL.	Tryptophan	110-120	Cbl proto-oncogene	Homo sapiens	148-153
16474167-6	2006	The PHD of FANCL also shares sequence similarity to the canonical RING finger of c-CBL, including a conserved tryptophan required for E2 binding by c-CBL.	Estradiol	134-136	Cbl proto-oncogene	Homo sapiens	81-86
16474167-6	2006	The PHD of FANCL also shares sequence similarity to the canonical RING finger of c-CBL, including a conserved tryptophan required for E2 binding by c-CBL.	Estradiol	134-136	Cbl proto-oncogene	Homo sapiens	148-153
16240321-7	2006	Exogenous PIP2, but not PI 3,4,5-bisphosphate, restored actin structure, Cbl activation, and GLUT4 translocation.	Phosphatidylinositol 4,5-Diphosphate	10-14	Cbl proto-oncogene	Homo sapiens	73-76
16503409-2	2006	We report that Cbl family members, Cbl and Cbl-b, are tyrosine-phosphorylated after SDF-1alpha/CXCL12 stimulation of Jurkat T cells.	Tyrosine	54-62	Cbl proto-oncogene	Homo sapiens	15-18
16503409-2	2006	We report that Cbl family members, Cbl and Cbl-b, are tyrosine-phosphorylated after SDF-1alpha/CXCL12 stimulation of Jurkat T cells.	Tyrosine	54-62	Cbl proto-oncogene	Homo sapiens	35-38
16464094-1	2006	The electrochemical (EC) reduction mechanism of methylcobalamin (Me-Cbl) in a mixed DMF/MeOH solvent in 0.2 M tetrabutylammonium fluoroborate electrolyte was studied as a function of temperature and solvent ratio vs a nonaqueous Ag/AgCl/Cl(-) reference electrode.	mecobalamin	48-63	Cbl proto-oncogene	Homo sapiens	68-71
16479008-7	2006	Previous studies have shown that growth factor stimulation induces the proteolytic degradation of hSpry2 by stimulating tyrosine phosphorylation on hSpry2, which in turn promotes c-Cbl binding and polyubiquitination.	Tyrosine	120-128	Cbl proto-oncogene	Homo sapiens	179-184
16479008-8	2006	A mutant of hSpry2 that is deficient in serine phosphorylation displays enhanced tyrosine phosphorylation and c-Cbl binding, indicating that serine phosphorylation stabilizes hSpry2 by exerting an antagonistic effect on tyrosine phosphorylation.	Serine	40-46	Cbl proto-oncogene	Homo sapiens	110-115
16479008-8	2006	A mutant of hSpry2 that is deficient in serine phosphorylation displays enhanced tyrosine phosphorylation and c-Cbl binding, indicating that serine phosphorylation stabilizes hSpry2 by exerting an antagonistic effect on tyrosine phosphorylation.	Serine	141-147	Cbl proto-oncogene	Homo sapiens	110-115
16479008-8	2006	A mutant of hSpry2 that is deficient in serine phosphorylation displays enhanced tyrosine phosphorylation and c-Cbl binding, indicating that serine phosphorylation stabilizes hSpry2 by exerting an antagonistic effect on tyrosine phosphorylation.	Tyrosine	220-228	Cbl proto-oncogene	Homo sapiens	110-115
16275144-5	2006	MG132 treatment resulted in stabilization of EGFR tyrosine phosphorylation and its association with c-Cbl.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	0-5	Cbl proto-oncogene	Homo sapiens	100-105
16441149-1	2006	The reactions of aquacobalamin (Cbl(III)H2O, vitamin B12a) and reduced cobalamin (Cbl(II), vitamin B12r) with the nitrosothiols S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylpenicillamine (SNAP) were studied in aqueous solution at pH 7.4.	aquacobalamin	17-30	Cbl proto-oncogene	Homo sapiens	32-35
16441149-1	2006	The reactions of aquacobalamin (Cbl(III)H2O, vitamin B12a) and reduced cobalamin (Cbl(II), vitamin B12r) with the nitrosothiols S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylpenicillamine (SNAP) were studied in aqueous solution at pH 7.4.	Vitamin B 12	21-30	Cbl proto-oncogene	Homo sapiens	32-35
16441149-1	2006	The reactions of aquacobalamin (Cbl(III)H2O, vitamin B12a) and reduced cobalamin (Cbl(II), vitamin B12r) with the nitrosothiols S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylpenicillamine (SNAP) were studied in aqueous solution at pH 7.4.	S-Nitrosothiols	114-127	Cbl proto-oncogene	Homo sapiens	32-35
16441149-1	2006	The reactions of aquacobalamin (Cbl(III)H2O, vitamin B12a) and reduced cobalamin (Cbl(II), vitamin B12r) with the nitrosothiols S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylpenicillamine (SNAP) were studied in aqueous solution at pH 7.4.	S-Nitrosothiols	114-127	Cbl proto-oncogene	Homo sapiens	82-85
16441149-1	2006	The reactions of aquacobalamin (Cbl(III)H2O, vitamin B12a) and reduced cobalamin (Cbl(II), vitamin B12r) with the nitrosothiols S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylpenicillamine (SNAP) were studied in aqueous solution at pH 7.4.	S-Nitrosoglutathione	128-148	Cbl proto-oncogene	Homo sapiens	32-35
16441149-1	2006	The reactions of aquacobalamin (Cbl(III)H2O, vitamin B12a) and reduced cobalamin (Cbl(II), vitamin B12r) with the nitrosothiols S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylpenicillamine (SNAP) were studied in aqueous solution at pH 7.4.	S-Nitrosoglutathione	128-148	Cbl proto-oncogene	Homo sapiens	82-85
16441149-4	2006	Reactions of aquacobalamin with GSNO and SNAP involve initial formation of Cbl(III)-RSNO adducts followed by nitrosothiol decomposition via heterolytic S-NO bond cleavage.	S-Nitrosoglutathione	32-36	Cbl proto-oncogene	Homo sapiens	75-78
16441149-5	2006	Formation of Cbl(III)(NO-) as the main cobalamin product indicates that the latter step leads to efficient transfer of the NO- group to the Co(III) center with concomitant oxidation of the nitrosothiol.	co(iii)	140-147	Cbl proto-oncogene	Homo sapiens	13-16
16441149-5	2006	Formation of Cbl(III)(NO-) as the main cobalamin product indicates that the latter step leads to efficient transfer of the NO- group to the Co(III) center with concomitant oxidation of the nitrosothiol.	S-Nitrosothiols	189-201	Cbl proto-oncogene	Homo sapiens	13-16
16441149-6	2006	Considerably faster reactions with Cbl(II) proceed through initial Cbl(II)-RSNO intermediates, which undergo subsequent electron-transfer processes leading to oxidation of the cobalt center and reduction of the nitrosothiol.	rsno	75-79	Cbl proto-oncogene	Homo sapiens	35-38
16441149-6	2006	Considerably faster reactions with Cbl(II) proceed through initial Cbl(II)-RSNO intermediates, which undergo subsequent electron-transfer processes leading to oxidation of the cobalt center and reduction of the nitrosothiol.	rsno	75-79	Cbl proto-oncogene	Homo sapiens	67-70
16441149-6	2006	Considerably faster reactions with Cbl(II) proceed through initial Cbl(II)-RSNO intermediates, which undergo subsequent electron-transfer processes leading to oxidation of the cobalt center and reduction of the nitrosothiol.	Cobalt	176-182	Cbl proto-oncogene	Homo sapiens	35-38
16441149-6	2006	Considerably faster reactions with Cbl(II) proceed through initial Cbl(II)-RSNO intermediates, which undergo subsequent electron-transfer processes leading to oxidation of the cobalt center and reduction of the nitrosothiol.	Cobalt	176-182	Cbl proto-oncogene	Homo sapiens	67-70
16441149-6	2006	Considerably faster reactions with Cbl(II) proceed through initial Cbl(II)-RSNO intermediates, which undergo subsequent electron-transfer processes leading to oxidation of the cobalt center and reduction of the nitrosothiol.	S-Nitrosothiols	211-223	Cbl proto-oncogene	Homo sapiens	35-38
16441149-6	2006	Considerably faster reactions with Cbl(II) proceed through initial Cbl(II)-RSNO intermediates, which undergo subsequent electron-transfer processes leading to oxidation of the cobalt center and reduction of the nitrosothiol.	S-Nitrosothiols	211-223	Cbl proto-oncogene	Homo sapiens	67-70
16441149-7	2006	In the case of GSNO, the overall reaction is fast (k approximately 1.2 x 10(6) M(-1) s(-1)) and leads to formation of glutathionylcobalamin (Cbl(III)SG) and nitrosylcobalamin (Cbl(III)(NO-)) as the final cobalamin products.	S-Nitrosoglutathione	15-19	Cbl proto-oncogene	Homo sapiens	141-151
16441149-7	2006	In the case of GSNO, the overall reaction is fast (k approximately 1.2 x 10(6) M(-1) s(-1)) and leads to formation of glutathionylcobalamin (Cbl(III)SG) and nitrosylcobalamin (Cbl(III)(NO-)) as the final cobalamin products.	S-Nitrosoglutathione	15-19	Cbl proto-oncogene	Homo sapiens	141-144
16441149-7	2006	In the case of GSNO, the overall reaction is fast (k approximately 1.2 x 10(6) M(-1) s(-1)) and leads to formation of glutathionylcobalamin (Cbl(III)SG) and nitrosylcobalamin (Cbl(III)(NO-)) as the final cobalamin products.	glutathionylcobalamin	118-139	Cbl proto-oncogene	Homo sapiens	141-151
16441149-7	2006	In the case of GSNO, the overall reaction is fast (k approximately 1.2 x 10(6) M(-1) s(-1)) and leads to formation of glutathionylcobalamin (Cbl(III)SG) and nitrosylcobalamin (Cbl(III)(NO-)) as the final cobalamin products.	glutathionylcobalamin	118-139	Cbl proto-oncogene	Homo sapiens	141-144
16441149-7	2006	In the case of GSNO, the overall reaction is fast (k approximately 1.2 x 10(6) M(-1) s(-1)) and leads to formation of glutathionylcobalamin (Cbl(III)SG) and nitrosylcobalamin (Cbl(III)(NO-)) as the final cobalamin products.	nitrosylcobalamin	157-174	Cbl proto-oncogene	Homo sapiens	141-144
16441149-8	2006	A mechanism involving the reversible equilibrium Cbl(II) + RSNO &lt;==&gt; Cbl(III)SR + NO is suggested for the reaction on the basis of the obtained kinetic and mechanistic information.	rsno	59-63	Cbl proto-oncogene	Homo sapiens	49-52
16441149-8	2006	A mechanism involving the reversible equilibrium Cbl(II) + RSNO &lt;==&gt; Cbl(III)SR + NO is suggested for the reaction on the basis of the obtained kinetic and mechanistic information.	rsno	59-63	Cbl proto-oncogene	Homo sapiens	75-78
16472699-3	2006	TC10 activation by insulin is catalyzed by the exchange factor C3G, which is translocated to lipid rafts along with its binding partner CrkII as a consequence of Cbl tyrosine phosphorylation by the insulin receptor.	Tyrosine	166-174	Cbl proto-oncogene	Homo sapiens	162-165
16285720-2	2005	To initiate catalysis, the 5"-deoxyadenosylcobalamin (AdoCbl) cofactor"s Co-C bond is cleaved homolytically to generate an adenosyl radical and Co2+ Cbl.	cobamamide	27-52	Cbl proto-oncogene	Homo sapiens	57-60
16305240-3	2005	Our data reveal a fairly uniform stabilization of the Co 3d orbitals relative to the corrin pi/pi*-based molecular orbitals when Co2+ Cbl is bound to the enzyme active site, particularly in the presence of substrate.	corrin	85-91	Cbl proto-oncogene	Homo sapiens	134-137
16305240-10	2005	Collectively, these observations provide direct evidence that enzymatic Co-C bond activation involves stabilization of the post-homolysis product, Co2+ Cbl, rather than destabilization of the Co3+ Cbl "ground" state.	Cobalt	0-2	Cbl proto-oncogene	Homo sapiens	152-155
16305240-10	2005	Collectively, these observations provide direct evidence that enzymatic Co-C bond activation involves stabilization of the post-homolysis product, Co2+ Cbl, rather than destabilization of the Co3+ Cbl "ground" state.	Carbon	0-1	Cbl proto-oncogene	Homo sapiens	152-155
16285720-2	2005	To initiate catalysis, the 5"-deoxyadenosylcobalamin (AdoCbl) cofactor"s Co-C bond is cleaved homolytically to generate an adenosyl radical and Co2+ Cbl.	adenosyl radical	123-139	Cbl proto-oncogene	Homo sapiens	57-60
16285720-4	2005	Minimal perturbations to the electronic absorption (Abs), circular dichroism (CD), and magnetic CD (MCD) spectra of AdoCbl are observed upon formation of holoenzyme, even in the presence of substrate (or a substrate analogue), indicating that destabilization of the Co3+ Cbl "ground state" is an unlikely mechanism for Co-C bond activation.	co-c	319-323	Cbl proto-oncogene	Homo sapiens	119-122
16285720-6	2005	These enzymatic perturbations appear to most strongly affect the metal-to-ligand charge-transfer transitions of Co2+ Cbl, suggesting that the cofactor/active-site interactions give rise to a fairly uniform stabilization of the Co 3d orbitals.	Metals	65-70	Cbl proto-oncogene	Homo sapiens	117-120
16285720-7	2005	Remarkable similarities between the results obtained in this study and those reported previously for the related Cbl-dependent isomerase methylmalonyl-CoA mutase indicate that a common mechanism by which the cofactor"s Co-C bond is activated for homolytic cleavage may be operative for all base-off/His-on Cbl-dependent isomerases.	Histidine	299-302	Cbl proto-oncogene	Homo sapiens	113-116
16285720-7	2005	Remarkable similarities between the results obtained in this study and those reported previously for the related Cbl-dependent isomerase methylmalonyl-CoA mutase indicate that a common mechanism by which the cofactor"s Co-C bond is activated for homolytic cleavage may be operative for all base-off/His-on Cbl-dependent isomerases.	Histidine	299-302	Cbl proto-oncogene	Homo sapiens	306-309
16227032-1	2005	OBJECTIVE: To evaluate prenatal treatment with hydroxycobalamin (OH-Cbl) in a pregnancy at risk for a severe form of the cobalamin C defect and postnatal treatment of the affected child.	Hydroxocobalamin	47-63	Cbl proto-oncogene	Homo sapiens	68-71
16168963-1	2005	The novel insulin receptor substrate protein APS is highly expressed in insulin-sensitive tissues and plays an important role in insulin-mediated glucose uptake and GLUT4 translocation via the Cbl/CAP pathway.	Glucose	146-153	Cbl proto-oncogene	Homo sapiens	193-196
16168963-2	2005	Tyrosine phosphorylation of APS leads to recruitment of c-Cbl and Crk, while overexpression of APS mutant inhibits GLUT4 translocation in response to insulin, but the regulation of APS expression in skeletal muscle has not been previously reported.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	56-61
16228008-2	2005	Their function is modulated through interactions with regulatory proteins including CIN85 and PIX, which recognize a proline-arginine motif in Cbl and thus promote or inhibit receptor endocytosis.	Proline	117-124	Cbl proto-oncogene	Homo sapiens	143-146
16228008-2	2005	Their function is modulated through interactions with regulatory proteins including CIN85 and PIX, which recognize a proline-arginine motif in Cbl and thus promote or inhibit receptor endocytosis.	Arginine	125-133	Cbl proto-oncogene	Homo sapiens	143-146
16227032-1	2005	OBJECTIVE: To evaluate prenatal treatment with hydroxycobalamin (OH-Cbl) in a pregnancy at risk for a severe form of the cobalamin C defect and postnatal treatment of the affected child.	cobalamin c	121-132	Cbl proto-oncogene	Homo sapiens	68-71
15922744-4	2005	This effect of c-Cbl depends on its tyrosine phosphorylation, specifically on phosphorylation of its Tyr-731, which is required for binding of PI-3" kinase to c-Cbl.	Tyrosine	36-44	Cbl proto-oncogene	Homo sapiens	15-20
16105874-1	2005	One of the main goals of this study was to understand the relationship between an epidermal growth factor (EGF) receptor dileucine (LL)-motif (679-LL) required for lysosomal sorting and the protein ubiquitin ligase CBL.	dileucine	121-130	Cbl proto-oncogene	Homo sapiens	215-218
16105874-2	2005	We show that receptors containing 679-AA (di-alanine) substitutions that are defective for ligand-induced degradation nevertheless bind CBL and undergo reversible protein ubiquitylation similar to wild-type receptors.	alanylalanine	42-52	Cbl proto-oncogene	Homo sapiens	136-139
15922744-4	2005	This effect of c-Cbl depends on its tyrosine phosphorylation, specifically on phosphorylation of its Tyr-731, which is required for binding of PI-3" kinase to c-Cbl.	Tyrosine	101-104	Cbl proto-oncogene	Homo sapiens	15-20
15922744-4	2005	This effect of c-Cbl depends on its tyrosine phosphorylation, specifically on phosphorylation of its Tyr-731, which is required for binding of PI-3" kinase to c-Cbl.	Tyrosine	101-104	Cbl proto-oncogene	Homo sapiens	159-164
15913339-4	2005	This interaction becomes much stronger in the presence of ATP, leading to the formation of an unprecedented Co2+Cbl species with spectroscopic signatures consistent with an essentially four-coordinate, square-planar Co2+ center.	Adenosine Triphosphate	58-61	Cbl proto-oncogene	Homo sapiens	112-115
15913339-1	2005	The human adenosyltransferase hATR converts exogenous cobalamin into coenzyme B12 by transferring the adenosyl group from cosubstrate ATP to a transiently formed Co1+cobalamin (Co1+Cbl) species.	Vitamin B 12	54-63	Cbl proto-oncogene	Homo sapiens	181-184
15872089-5	2005	The association of dynamin with Cbl in osteoclasts was decreased by Src tyrosine kinase activity and we found that destabilization of the dynamin-Cbl complex involves the recruitment of Src through the proline-rich domain of Cbl.	Proline	202-209	Cbl proto-oncogene	Homo sapiens	146-149
15872089-5	2005	The association of dynamin with Cbl in osteoclasts was decreased by Src tyrosine kinase activity and we found that destabilization of the dynamin-Cbl complex involves the recruitment of Src through the proline-rich domain of Cbl.	Proline	202-209	Cbl proto-oncogene	Homo sapiens	146-149
15892963-7	2005	Furthermore, Lck is required for Nef-mediated c-Cbl tyrosine phosphorylation.	Tyrosine	52-60	Cbl proto-oncogene	Homo sapiens	46-51
15737992-0	2005	Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins.	Phosphotyrosine	43-58	Cbl proto-oncogene	Homo sapiens	39-42
15913339-1	2005	The human adenosyltransferase hATR converts exogenous cobalamin into coenzyme B12 by transferring the adenosyl group from cosubstrate ATP to a transiently formed Co1+cobalamin (Co1+Cbl) species.	co1+cobalamin	162-175	Cbl proto-oncogene	Homo sapiens	181-184
15913339-3	2005	Our magnetic circular dichroism and electron paramagnetic resonance spectroscopic studies reported here reveal that, in the absence of ATP, the interaction between Co2+Cbl and hATR promotes partial conversion of the cofactor to its "base-off" form in which a water molecule occupies the lower axial position.	Water	259-264	Cbl proto-oncogene	Homo sapiens	168-171
15737992-2	2005	Cbl proteins bind to specific tyrosine-phosphorylated sequences in target proteins via the tyrosine kinase-binding (TKB) domain, which comprises a four-helix bundle, an EF-hand calcium-binding domain, and a non-conventional Src homology-2 domain.	Tyrosine	30-38	Cbl proto-oncogene	Homo sapiens	0-3
15737992-2	2005	Cbl proteins bind to specific tyrosine-phosphorylated sequences in target proteins via the tyrosine kinase-binding (TKB) domain, which comprises a four-helix bundle, an EF-hand calcium-binding domain, and a non-conventional Src homology-2 domain.	Calcium	177-184	Cbl proto-oncogene	Homo sapiens	0-3
15737992-3	2005	The previously derived consensus sequence for phosphotyrosine recognition by the Cbl TKB domain is NXpY(S/T)XXP (X denotes lesser residue preference), wherein specificity is conferred primarily by residues C-terminal to the phosphotyrosine.	Phosphotyrosine	46-61	Cbl proto-oncogene	Homo sapiens	81-84
15737992-3	2005	The previously derived consensus sequence for phosphotyrosine recognition by the Cbl TKB domain is NXpY(S/T)XXP (X denotes lesser residue preference), wherein specificity is conferred primarily by residues C-terminal to the phosphotyrosine.	Phosphotyrosine	224-239	Cbl proto-oncogene	Homo sapiens	81-84
15737992-5	2005	APS is phosphorylated by the insulin receptor on a C-terminal tyrosine residue, which then serves as a binding site for the Cbl TKB domain.	Adenosine Phosphosulfate	0-3	Cbl proto-oncogene	Homo sapiens	124-127
15737992-5	2005	APS is phosphorylated by the insulin receptor on a C-terminal tyrosine residue, which then serves as a binding site for the Cbl TKB domain.	Tyrosine	62-70	Cbl proto-oncogene	Homo sapiens	124-127
15737992-6	2005	Using x-ray crystallography, site-directed mutagenesis, and calorimetric studies, we have characterized the interaction between the Cbl TKB domain and the Cbl recruitment site in APS, which contains a sequence motif, RA(V/I)XNQpY(S/T), that is conserved in the related adapter proteins SH2-B and Lnk.	Adenosine Phosphosulfate	179-182	Cbl proto-oncogene	Homo sapiens	132-135
15737992-6	2005	Using x-ray crystallography, site-directed mutagenesis, and calorimetric studies, we have characterized the interaction between the Cbl TKB domain and the Cbl recruitment site in APS, which contains a sequence motif, RA(V/I)XNQpY(S/T), that is conserved in the related adapter proteins SH2-B and Lnk.	Adenosine Phosphosulfate	179-182	Cbl proto-oncogene	Homo sapiens	155-158
15737992-7	2005	These studies reveal a novel mode of phosphopeptide interaction with the Cbl TKB domain, in which N-terminal residues distal to the phosphotyrosine directly contact residues of the four-helix bundle of the TKB domain.	Phosphotyrosine	132-147	Cbl proto-oncogene	Homo sapiens	73-76
15708858-9	2005	Activation of wild type PAR(2) stimulated tyrosine phosphorylation of the ubiquitin-protein isopeptide ligase c-Cbl and promoted its interaction with PAR(2) at the plasma membrane and in endosomes in an Src-dependent manner.	Tyrosine	42-50	Cbl proto-oncogene	Homo sapiens	110-115
15878338-4	2005	However, the character of the interactions described in this report is novel, since the G306E mutation, which disrupts the ability of c-Cbl"s TKB to bind to tyrosine-phosphorylated proteins, does not affect the observed interaction between c-Cbl and microtubules.	Tyrosine	157-165	Cbl proto-oncogene	Homo sapiens	134-139
15677445-6	2005	A constitutive complex of Grb2 and Cbl could be recruited to both receptor isoforms via docking of Shc to phosphorylated Tyr-1062 in RET.	Tyrosine	121-124	Cbl proto-oncogene	Homo sapiens	35-38
15677445-8	2005	In addition, phosphorylation of Tyr-1096, which is present in RET51 but absent in RET9, endowed the longer isoform with a second route to recruit the Grb2.Cbl complex.	Tyrosine	32-35	Cbl proto-oncogene	Homo sapiens	155-158
15657067-7	2005	Pharmacological inhibition of EGF receptor kinase activity by erlotinib resulted in reduced phosphorylation of downstream signaling, for example through Cbl/Cbl-B, phospholipase Cgamma (PLCgamma), Erk1/2, PI-3 kinase, and STAT3/5.	Erlotinib Hydrochloride	62-71	Cbl proto-oncogene	Homo sapiens	153-156
15652495-1	2005	Cellular uptake of vitamin B(12) (cobalamin, Cbl) is mediated by a receptor expressed on the plasma membrane that binds transcobalamin (TC) saturated with Cbl and internalizes the TC-Cbl by endocytosis.	Niacinamide	19-28	Cbl proto-oncogene	Homo sapiens	45-48
15652495-1	2005	Cellular uptake of vitamin B(12) (cobalamin, Cbl) is mediated by a receptor expressed on the plasma membrane that binds transcobalamin (TC) saturated with Cbl and internalizes the TC-Cbl by endocytosis.	Niacinamide	19-28	Cbl proto-oncogene	Homo sapiens	155-158
15652495-1	2005	Cellular uptake of vitamin B(12) (cobalamin, Cbl) is mediated by a receptor expressed on the plasma membrane that binds transcobalamin (TC) saturated with Cbl and internalizes the TC-Cbl by endocytosis.	Niacinamide	19-28	Cbl proto-oncogene	Homo sapiens	155-158
15652495-1	2005	Cellular uptake of vitamin B(12) (cobalamin, Cbl) is mediated by a receptor expressed on the plasma membrane that binds transcobalamin (TC) saturated with Cbl and internalizes the TC-Cbl by endocytosis.	Vitamin B 12	34-43	Cbl proto-oncogene	Homo sapiens	45-48
15652495-1	2005	Cellular uptake of vitamin B(12) (cobalamin, Cbl) is mediated by a receptor expressed on the plasma membrane that binds transcobalamin (TC) saturated with Cbl and internalizes the TC-Cbl by endocytosis.	Vitamin B 12	34-43	Cbl proto-oncogene	Homo sapiens	155-158
15652495-1	2005	Cellular uptake of vitamin B(12) (cobalamin, Cbl) is mediated by a receptor expressed on the plasma membrane that binds transcobalamin (TC) saturated with Cbl and internalizes the TC-Cbl by endocytosis.	Vitamin B 12	34-43	Cbl proto-oncogene	Homo sapiens	155-158
15475003-0	2004	Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation.	Phosphotyrosine	31-35	Cbl proto-oncogene	Homo sapiens	22-25
15536084-4	2005	Interestingly, this domain interacted with Syk at phosphotyrosine 317, a site phosphorylated in trans by the Src family kinase, Lyn, and identified previously as a binding site for c-Cbl.	Phosphotyrosine	50-65	Cbl proto-oncogene	Homo sapiens	181-186
15556646-4	2004	We found that each kinase produced a distinct pattern of c-Cbl phosphorylation, which altered the phosphotyrosine-dependent interactions between c-Cbl and CrkL or phosphatidylinositol 3"-kinase (PI3-K).	Phosphotyrosine	98-113	Cbl proto-oncogene	Homo sapiens	57-62
15556646-4	2004	We found that each kinase produced a distinct pattern of c-Cbl phosphorylation, which altered the phosphotyrosine-dependent interactions between c-Cbl and CrkL or phosphatidylinositol 3"-kinase (PI3-K).	Phosphotyrosine	98-113	Cbl proto-oncogene	Homo sapiens	145-150
15702190-1	2005	Ligand substitution reactions of the vitamin B12 analog cyanoimidazolylcobamide, CN(Im)Cbl, with cyanide were studied.	Vitamin B 12	37-48	Cbl proto-oncogene	Homo sapiens	87-90
15702190-1	2005	Ligand substitution reactions of the vitamin B12 analog cyanoimidazolylcobamide, CN(Im)Cbl, with cyanide were studied.	Cyanides	97-104	Cbl proto-oncogene	Homo sapiens	87-90
15702190-5	2005	The equilibrium constant for the reaction of CN(Im)Cbl with CN- was found to be 861 +/- 75 M(-1), which is significantly less than that obtained for the reaction of cyanocobalamin with CN- (viz.	Vitamin B 12	165-179	Cbl proto-oncogene	Homo sapiens	51-54
15690085-3	2005	Here we show that CI-1033 and related 4-anilinoquinazolines inhibit SPGF-induced human cellular DNA synthesis, protein tyrosine kinase activation, and c-Cbl association with ErbB-1 and resultant internalization.	Canertinib	18-25	Cbl proto-oncogene	Homo sapiens	151-156
15690085-3	2005	Here we show that CI-1033 and related 4-anilinoquinazolines inhibit SPGF-induced human cellular DNA synthesis, protein tyrosine kinase activation, and c-Cbl association with ErbB-1 and resultant internalization.	anilinoquinazoline	38-59	Cbl proto-oncogene	Homo sapiens	151-156
15650401-7	2005	Under oxidative stress, phosphorylation of the epidermal growth factor receptor (EGFR) is abrogated at tyrosine 1,045, the docking site for the ubiquitin ligase c-Cbl, rendering EGFR unable to recruit c-Cbl and be ubiquitylated and degraded.	Tyrosine	103-111	Cbl proto-oncogene	Homo sapiens	161-166
15650401-7	2005	Under oxidative stress, phosphorylation of the epidermal growth factor receptor (EGFR) is abrogated at tyrosine 1,045, the docking site for the ubiquitin ligase c-Cbl, rendering EGFR unable to recruit c-Cbl and be ubiquitylated and degraded.	Tyrosine	103-111	Cbl proto-oncogene	Homo sapiens	201-206
15465819-6	2004	These are either dependent on the phosphotyrosine binding domain of c-Cbl that directly binds to the EGFR or on the region C-terminal of the Ring finger, which allows for indirect binding to an alternative site on the receptor.	Phosphotyrosine	34-49	Cbl proto-oncogene	Homo sapiens	68-73
15581361-0	2004	Requirements for pYXXM motifs in Cbl for binding to the p85 subunit of phosphatidylinositol 3-kinase and Crk, and activation of atypical protein kinase C and glucose transport during insulin action in 3T3/L1 adipocytes.	Glucose	158-165	Cbl proto-oncogene	Homo sapiens	33-36
15581361-1	2004	Cbl is phosphorylated by the insulin receptor and reportedly functions within the flotillin/CAP/Cbl/Crk/C3G/TC10 complex during insulin-stimulated glucose transport in 3T3/L1 adipocytes.	Glucose	147-154	Cbl proto-oncogene	Homo sapiens	0-3
15581361-1	2004	Cbl is phosphorylated by the insulin receptor and reportedly functions within the flotillin/CAP/Cbl/Crk/C3G/TC10 complex during insulin-stimulated glucose transport in 3T3/L1 adipocytes.	Glucose	147-154	Cbl proto-oncogene	Homo sapiens	96-99
15581361-2	2004	Cbl, via pYXXM motifs at tyrosine-371 and tyrosine-731, also activates phosphatidylinositol (PI) 3-kinase, which is required to activate atypical protein kinase C (aPKC) and glucose transport during thiazolidinedione action in 3T3/L1 and human adipocytes [Miura et al.	Tyrosine	25-33	Cbl proto-oncogene	Homo sapiens	0-3
15581361-2	2004	Cbl, via pYXXM motifs at tyrosine-371 and tyrosine-731, also activates phosphatidylinositol (PI) 3-kinase, which is required to activate atypical protein kinase C (aPKC) and glucose transport during thiazolidinedione action in 3T3/L1 and human adipocytes [Miura et al.	Tyrosine	42-50	Cbl proto-oncogene	Homo sapiens	0-3
15581361-2	2004	Cbl, via pYXXM motifs at tyrosine-371 and tyrosine-731, also activates phosphatidylinositol (PI) 3-kinase, which is required to activate atypical protein kinase C (aPKC) and glucose transport during thiazolidinedione action in 3T3/L1 and human adipocytes [Miura et al.	Glucose	174-181	Cbl proto-oncogene	Homo sapiens	0-3
15581361-2	2004	Cbl, via pYXXM motifs at tyrosine-371 and tyrosine-731, also activates phosphatidylinositol (PI) 3-kinase, which is required to activate atypical protein kinase C (aPKC) and glucose transport during thiazolidinedione action in 3T3/L1 and human adipocytes [Miura et al.	2,4-thiazolidinedione	199-216	Cbl proto-oncogene	Homo sapiens	0-3
15581361-5	2004	Interestingly, these mutants inhibited insulin-induced increases in (a) binding of Cbl to both Crk and the p85 subunit of PI 3-kinase, (b) activation of Cbl-dependent PI 3-kinase, (c) activation and translocation of aPKC to the plasma membrane, (d) translocation of Glut4 to the plasma membrane, (e) and glucose transport.	Glucose	304-311	Cbl proto-oncogene	Homo sapiens	83-86
15581361-5	2004	Interestingly, these mutants inhibited insulin-induced increases in (a) binding of Cbl to both Crk and the p85 subunit of PI 3-kinase, (b) activation of Cbl-dependent PI 3-kinase, (c) activation and translocation of aPKC to the plasma membrane, (d) translocation of Glut4 to the plasma membrane, (e) and glucose transport.	Glucose	304-311	Cbl proto-oncogene	Homo sapiens	153-156
15581361-8	2004	Our findings suggest that (a) Cbl uses pYXXM motifs to simultaneously activate PI 3-kinase and Crk/C3G/TC10 pathways and (b) Cbl, along with IRS-1, functions upstream of PI 3-kinase and aPKCs during insulin-stimulated glucose transport in 3T3/L1 adipocytes.	Glucose	218-225	Cbl proto-oncogene	Homo sapiens	30-33
15581361-8	2004	Our findings suggest that (a) Cbl uses pYXXM motifs to simultaneously activate PI 3-kinase and Crk/C3G/TC10 pathways and (b) Cbl, along with IRS-1, functions upstream of PI 3-kinase and aPKCs during insulin-stimulated glucose transport in 3T3/L1 adipocytes.	Glucose	218-225	Cbl proto-oncogene	Homo sapiens	125-128
15488467-4	2004	These studies show that (a) two of the three polar residues, S174, T177, or D176 and two of the three conserved alanine residues, A179 and A184 present in the 15-residue evolutionary conserved region are essential for Cbl-binding by human TC, and (b) TC gene is transferred in a syntenic manner to different chromosomes, at least before the divergence of mouse/rat and human.	Alanine	112-119	Cbl proto-oncogene	Homo sapiens	218-221
15337528-0	2004	c-Cbl binds to tyrosine-phosphorylated neurotrophin receptor p75 and induces its ubiquitination.	Tyrosine	15-23	Cbl proto-oncogene	Homo sapiens	0-5
15337528-3	2004	Phosphorylated tyrosine 308 constitutes a binding site for the ubiquitin ligase c-Cbl.	Tyrosine	15-23	Cbl proto-oncogene	Homo sapiens	80-85
15304502-3	2004	Cbl-/- B cells show impaired tyrosine phosphorylation, reduced Erk activation, and attenuated calcium mobilization in response to BCR engagement.	Tyrosine	29-37	Cbl proto-oncogene	Homo sapiens	0-3
15304502-3	2004	Cbl-/- B cells show impaired tyrosine phosphorylation, reduced Erk activation, and attenuated calcium mobilization in response to BCR engagement.	Calcium	94-101	Cbl proto-oncogene	Homo sapiens	0-3
15308131-1	2004	Methylmalonic acidemia (MMA) is caused by the deficient activity of l-methylmalonyl-CoA mutase, which is a vitamin B(12) (or cobalamin, Cbl)-dependent enzyme.	Niacinamide	107-116	Cbl proto-oncogene	Homo sapiens	136-139
15172888-2	2004	Although PI3K and Cbl mediate insulin-stimulated glucose uptake by promoting the translocation of the insulin-responsive glucose transporter (GLUT4) to the plasma membrane, the MAPK pathway does not have an established role in insulin-stimulated glucose uptake.	Glucose	49-56	Cbl proto-oncogene	Homo sapiens	18-21
15172888-2	2004	Although PI3K and Cbl mediate insulin-stimulated glucose uptake by promoting the translocation of the insulin-responsive glucose transporter (GLUT4) to the plasma membrane, the MAPK pathway does not have an established role in insulin-stimulated glucose uptake.	Glucose	121-128	Cbl proto-oncogene	Homo sapiens	18-21
15456872-6	2004	Increasing the level of Alix weakened the interaction between SETA/CIN85 and Cbl and reduced the tyrosine phosphorylation of c-Cbl and the level of ubiquitination of EGFR, SETA/CIN85, and Cbls.	Tyrosine	97-105	Cbl proto-oncogene	Homo sapiens	125-130
15306850-5	2004	The binding of either PAK (p21-activated kinase) or Cbl (Casitas B-lymphoma) to the SH3 domain of monomeric Cool-2 is necessary for the functional interactions between GDP-bound Cdc42 or Rac and the Cool-2 monomer.	Guanosine Diphosphate	168-171	Cbl proto-oncogene	Homo sapiens	52-55
15306850-5	2004	The binding of either PAK (p21-activated kinase) or Cbl (Casitas B-lymphoma) to the SH3 domain of monomeric Cool-2 is necessary for the functional interactions between GDP-bound Cdc42 or Rac and the Cool-2 monomer.	Guanosine Diphosphate	168-171	Cbl proto-oncogene	Homo sapiens	57-75
15190072-8	2004	Transfection with c-Cbl in which the RING finger was disrupted or with c-Cbl with a point mutation that abolishes the binding ability of the Cbl phosphotyrosine-binding domain restored Src kinase activity and Lyn, Fyn, and FGFR2 levels and reduced ALP up-regulation in mutant osteoblasts.	Phosphotyrosine	145-160	Cbl proto-oncogene	Homo sapiens	18-23
15190072-8	2004	Transfection with c-Cbl in which the RING finger was disrupted or with c-Cbl with a point mutation that abolishes the binding ability of the Cbl phosphotyrosine-binding domain restored Src kinase activity and Lyn, Fyn, and FGFR2 levels and reduced ALP up-regulation in mutant osteoblasts.	Phosphotyrosine	145-160	Cbl proto-oncogene	Homo sapiens	71-76
15291577-1	2004	Co(2+)cobalmain (Co(2+)Cbl) is implicated in the catalytic cycles of all adenosylcobalamin (AdoCbl)-dependent enzymes, as in each case catalysis is initiated through homolytic cleavage of the cofactor"s Co-C bond.	Cobalt(2+)	0-6	Cbl proto-oncogene	Homo sapiens	23-26
15308131-1	2004	Methylmalonic acidemia (MMA) is caused by the deficient activity of l-methylmalonyl-CoA mutase, which is a vitamin B(12) (or cobalamin, Cbl)-dependent enzyme.	Vitamin B 12	125-134	Cbl proto-oncogene	Homo sapiens	136-139
15117950-0	2004	Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations.	Tyrosine	137-145	Cbl proto-oncogene	Homo sapiens	51-56
15117950-0	2004	Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations.	Glutamic Acid	149-158	Cbl proto-oncogene	Homo sapiens	51-56
15117950-3	2004	We show here that the E3 activity of c-Cbl is negatively regulated by other domains present in the amino-terminal half of the protein (the TKB and linker helix domains) and that this negative regulation is removed when the protein is phosphorylated on tyrosine residues.	Tyrosine	252-260	Cbl proto-oncogene	Homo sapiens	37-42
15117950-4	2004	Protease digestion studies indicate that tyrosine phosphorylation alters the conformation of c-Cbl.	Tyrosine	41-49	Cbl proto-oncogene	Homo sapiens	93-98
15117950-5	2004	We also show that mutation of certain conserved tyrosine residues to glutamate can constitutively activate the E3 activity of c-Cbl.	Tyrosine	48-56	Cbl proto-oncogene	Homo sapiens	126-131
15117950-5	2004	We also show that mutation of certain conserved tyrosine residues to glutamate can constitutively activate the E3 activity of c-Cbl.	Glutamic Acid	69-78	Cbl proto-oncogene	Homo sapiens	126-131
15117950-7	2004	The Y371E mutant also has altered protease sensitivity from wild type, instead resembling the proteolytic pattern seen with tyrosine-phosphorylated c-Cbl.	Tyrosine	124-132	Cbl proto-oncogene	Homo sapiens	148-153
15117950-9	2004	These studies argue that Tyr-371 plays a key role in activating the E3 activity of c-Cbl and that the Y371E mutant may partially mimic phosphorylation at that site.	Tyrosine	25-28	Cbl proto-oncogene	Homo sapiens	83-88
15117950-10	2004	However, Tyr-371 point mutants of c-Cbl are still able to undergo phosphorylation-induced E3 activation, and we show that Tyr-368 can also be phosphorylated in addition to Tyr-371, and contributes to activation.	Tyrosine	9-12	Cbl proto-oncogene	Homo sapiens	34-39
15117950-10	2004	However, Tyr-371 point mutants of c-Cbl are still able to undergo phosphorylation-induced E3 activation, and we show that Tyr-368 can also be phosphorylated in addition to Tyr-371, and contributes to activation.	Tyrosine	122-125	Cbl proto-oncogene	Homo sapiens	34-39
15117950-10	2004	However, Tyr-371 point mutants of c-Cbl are still able to undergo phosphorylation-induced E3 activation, and we show that Tyr-368 can also be phosphorylated in addition to Tyr-371, and contributes to activation.	Tyrosine	122-125	Cbl proto-oncogene	Homo sapiens	34-39
15161351-5	2004	Furthermore, the UV-radiation-induced internalization was abrogated for an EGFR mutated in tyrosine 1045 (Y1045F), the major c-Cbl binding site.	Tyrosine	91-99	Cbl proto-oncogene	Homo sapiens	125-130
15203205-2	2004	Expansion of CGG/CCG repeats has been shown to be the molecular basis of all five folate-sensitive fragile sites characterized molecularly so far, i.e., FRAXA, FRAXE, FRAXF, FRA11B, and FRA16A.	Folic Acid	82-88	Cbl proto-oncogene	Homo sapiens	174-180
15090612-2	2004	CIN85 src homology 3 domains specifically bind to a proline-arginine (PxxxPR) motif in Cbl, and this association seems to be important for EGF receptor endocytosis.	proline-arginine	52-68	Cbl proto-oncogene	Homo sapiens	87-90
15123609-0	2004	A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation.	deoxypyridinoline	12-16	Cbl proto-oncogene	Homo sapiens	96-101
15123609-5	2004	By alanine-scanning mutagenesis, we have identified a DpYR motif including Tyr(1003) as being important for the direct recruitment of the c-Cbl TKB domain and for ubiquitination of the Met receptor.	Alanine	3-10	Cbl proto-oncogene	Homo sapiens	138-143
15123609-5	2004	By alanine-scanning mutagenesis, we have identified a DpYR motif including Tyr(1003) as being important for the direct recruitment of the c-Cbl TKB domain and for ubiquitination of the Met receptor.	Tyrosine	75-78	Cbl proto-oncogene	Homo sapiens	138-143
15123609-6	2004	The substitution of Tyr(1003) with phenylalanine or substitution of either aspartate or arginine residues with alanine impairs c-Cbl-recruitment and ubiquitination of Met and results in the oncogenic activation of the Met receptor.	Aspartic Acid	75-84	Cbl proto-oncogene	Homo sapiens	127-132
15123609-6	2004	The substitution of Tyr(1003) with phenylalanine or substitution of either aspartate or arginine residues with alanine impairs c-Cbl-recruitment and ubiquitination of Met and results in the oncogenic activation of the Met receptor.	Arginine	88-96	Cbl proto-oncogene	Homo sapiens	127-132
15123609-8	2004	Modeling studies suggest the presence of a salt bridge between the aspartate and arginine residues that would position pTyr(1003) for binding to the c-Cbl TKB domain.	Aspartic Acid	67-76	Cbl proto-oncogene	Homo sapiens	149-154
15123609-8	2004	Modeling studies suggest the presence of a salt bridge between the aspartate and arginine residues that would position pTyr(1003) for binding to the c-Cbl TKB domain.	Arginine	81-89	Cbl proto-oncogene	Homo sapiens	149-154
15123609-8	2004	Modeling studies suggest the presence of a salt bridge between the aspartate and arginine residues that would position pTyr(1003) for binding to the c-Cbl TKB domain.	Phosphotyrosine	119-123	Cbl proto-oncogene	Homo sapiens	149-154
15226403-4	2004	Stimulation of these cells with mAb16-39 markedly induces the tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1), Shc, and c-Cbl and also their interaction with ALK and activation of ERK1/2.	Tyrosine	62-70	Cbl proto-oncogene	Homo sapiens	137-142
15169881-5	2004	Our studies showed that engagement of 2B4 on NK cells triggered a tyrosine phosphorylation signal implicating 2B4, Vav-1, and, to a lesser extent, SHIP-1 and c-Cbl.	Tyrosine	66-74	Cbl proto-oncogene	Homo sapiens	158-163
15135048-2	2004	We identified a specific polyproline motif of Cbl responsible for binding of SH3P2 and Src, and observed mutual sequestration of Src and SH3P2 from monomer Cbl molecules.	polyproline	25-36	Cbl proto-oncogene	Homo sapiens	46-49
15094368-1	2004	We found that engagement of beta2 integrins on human neutrophils triggered both tyrosine and serine phosphorylation of c-Cbl.	Serine	93-99	Cbl proto-oncogene	Homo sapiens	119-124
15094368-2	2004	Pretreatment of the neutrophils with the broad range protein kinase C (PKC) inhibitor GF-109203X blocked the serine but not the tyrosine phosphorylation of c-Cbl.	bisindolylmaleimide I	86-96	Cbl proto-oncogene	Homo sapiens	156-161
15094368-3	2004	Moreover, the Src kinase inhibitor PP1 prevented the beta2 integrin-induced tyrosine phosphorylation of c-Cbl but not the simultaneous serine phosphorylation.	Tyrosine	76-84	Cbl proto-oncogene	Homo sapiens	104-109
15094368-6	2004	Instead, c-Cbl that underwent PKC-induced serine phosphorylation associated with the scaffolding and anti-apoptotic 14-3-3 proteins.	Serine	42-48	Cbl proto-oncogene	Homo sapiens	9-14
14551058-6	2004	These effects were inhibited by SU-1498, a specific Flk-1 inhibitor, and by a negative mutant of Casitas B-lineage lymphoma (Cbl) with tyrosine-to-phenylalanine mutations at sites 700, 731, and 774 (Cbl(nm)).	SU 1498	32-39	Cbl proto-oncogene	Homo sapiens	199-202
15004239-5	2004	In contrast, Sprouty2 tyrosine phosphorylation was necessary for its binding to the Src homology 2-like domain of c-Cbl after fibroblast growth factor (FGF) stimulation.	Tyrosine	22-30	Cbl proto-oncogene	Homo sapiens	114-119
14551058-6	2004	These effects were inhibited by SU-1498, a specific Flk-1 inhibitor, and by a negative mutant of Casitas B-lineage lymphoma (Cbl) with tyrosine-to-phenylalanine mutations at sites 700, 731, and 774 (Cbl(nm)).	Tyrosine	135-143	Cbl proto-oncogene	Homo sapiens	97-123
14551058-6	2004	These effects were inhibited by SU-1498, a specific Flk-1 inhibitor, and by a negative mutant of Casitas B-lineage lymphoma (Cbl) with tyrosine-to-phenylalanine mutations at sites 700, 731, and 774 (Cbl(nm)).	Tyrosine	135-143	Cbl proto-oncogene	Homo sapiens	125-128
14551058-6	2004	These effects were inhibited by SU-1498, a specific Flk-1 inhibitor, and by a negative mutant of Casitas B-lineage lymphoma (Cbl) with tyrosine-to-phenylalanine mutations at sites 700, 731, and 774 (Cbl(nm)).	Phenylalanine	147-160	Cbl proto-oncogene	Homo sapiens	97-123
14551058-6	2004	These effects were inhibited by SU-1498, a specific Flk-1 inhibitor, and by a negative mutant of Casitas B-lineage lymphoma (Cbl) with tyrosine-to-phenylalanine mutations at sites 700, 731, and 774 (Cbl(nm)).	Phenylalanine	147-160	Cbl proto-oncogene	Homo sapiens	125-128
14551058-9	2004	Furthermore, SU-1498 and Cbl(-nm) abolished the shear- and VEGF-induced Akt activity, indicating that Akt acts at a level downstream to Flk-1 and Cbl.	SU 1498	13-20	Cbl proto-oncogene	Homo sapiens	146-149
14523017-4	2003	Furthermore, full phosphorylation of CD3-zeta and CD3-epsilon only occurs in rafts, whereas partial CD3-zeta tyrosine phosphorylation occurs exclusively in the soluble pool, which correlated with increased levels of c-Cbl tyrosine phosphorylation in the non-raft fractions.	Tyrosine	222-230	Cbl proto-oncogene	Homo sapiens	216-221
15319544-4	2004	RESULTS: Activity (nmol/h/mg protein) was maximal in cells cultivated in Hcy+Cbl+ (2.45 +/- 0.35), compared to cells cultivated in Hcy+Met+ (0.18 +/- 0.01, p&lt;0.001), in Met+ Cbl+ (1.60 +/- 0.06, p&lt;0.05), and in Met+ (0.40 +/- 0.05, p&lt;0.001), suggesting an adaptation of the cells to requirement in synthesized methionine.	Homocystine	73-76	Cbl proto-oncogene	Homo sapiens	77-81
14640702-1	2003	The thiazolidinedione (TZD), rosiglitazone, has previously been found to tyrosine-phosphorylate Cbl and activate Cbl-dependent phosphatidylinositol (PI) 3-kinase and atypical protein kinase Cs (aPKCs) while stimulating glucose transport in 3T3/L1 adipocytes.	2,4-thiazolidinedione	4-21	Cbl proto-oncogene	Homo sapiens	96-99
14640702-1	2003	The thiazolidinedione (TZD), rosiglitazone, has previously been found to tyrosine-phosphorylate Cbl and activate Cbl-dependent phosphatidylinositol (PI) 3-kinase and atypical protein kinase Cs (aPKCs) while stimulating glucose transport in 3T3/L1 adipocytes.	2,4-thiazolidinedione	4-21	Cbl proto-oncogene	Homo sapiens	113-116
14640702-0	2003	Cbl PYXXM motifs activate the P85 subunit of phosphatidylinositol 3-kinase, Crk, atypical protein kinase C, and glucose transport during thiazolidinedione action in 3T3/L1 and human adipocytes.	Glucose	112-119	Cbl proto-oncogene	Homo sapiens	0-3
14640702-0	2003	Cbl PYXXM motifs activate the P85 subunit of phosphatidylinositol 3-kinase, Crk, atypical protein kinase C, and glucose transport during thiazolidinedione action in 3T3/L1 and human adipocytes.	2,4-thiazolidinedione	137-154	Cbl proto-oncogene	Homo sapiens	0-3
14640702-1	2003	The thiazolidinedione (TZD), rosiglitazone, has previously been found to tyrosine-phosphorylate Cbl and activate Cbl-dependent phosphatidylinositol (PI) 3-kinase and atypical protein kinase Cs (aPKCs) while stimulating glucose transport in 3T3/L1 adipocytes.	2,4-thiazolidinedione	23-26	Cbl proto-oncogene	Homo sapiens	96-99
14640702-1	2003	The thiazolidinedione (TZD), rosiglitazone, has previously been found to tyrosine-phosphorylate Cbl and activate Cbl-dependent phosphatidylinositol (PI) 3-kinase and atypical protein kinase Cs (aPKCs) while stimulating glucose transport in 3T3/L1 adipocytes.	2,4-thiazolidinedione	23-26	Cbl proto-oncogene	Homo sapiens	113-116
14640702-1	2003	The thiazolidinedione (TZD), rosiglitazone, has previously been found to tyrosine-phosphorylate Cbl and activate Cbl-dependent phosphatidylinositol (PI) 3-kinase and atypical protein kinase Cs (aPKCs) while stimulating glucose transport in 3T3/L1 adipocytes.	Rosiglitazone	29-42	Cbl proto-oncogene	Homo sapiens	96-99
14640702-1	2003	The thiazolidinedione (TZD), rosiglitazone, has previously been found to tyrosine-phosphorylate Cbl and activate Cbl-dependent phosphatidylinositol (PI) 3-kinase and atypical protein kinase Cs (aPKCs) while stimulating glucose transport in 3T3/L1 adipocytes.	Rosiglitazone	29-42	Cbl proto-oncogene	Homo sapiens	113-116
14640702-1	2003	The thiazolidinedione (TZD), rosiglitazone, has previously been found to tyrosine-phosphorylate Cbl and activate Cbl-dependent phosphatidylinositol (PI) 3-kinase and atypical protein kinase Cs (aPKCs) while stimulating glucose transport in 3T3/L1 adipocytes.	Tyrosine	73-81	Cbl proto-oncogene	Homo sapiens	96-99
14640702-1	2003	The thiazolidinedione (TZD), rosiglitazone, has previously been found to tyrosine-phosphorylate Cbl and activate Cbl-dependent phosphatidylinositol (PI) 3-kinase and atypical protein kinase Cs (aPKCs) while stimulating glucose transport in 3T3/L1 adipocytes.	Phosphatidylinositols	127-147	Cbl proto-oncogene	Homo sapiens	113-116
14640702-1	2003	The thiazolidinedione (TZD), rosiglitazone, has previously been found to tyrosine-phosphorylate Cbl and activate Cbl-dependent phosphatidylinositol (PI) 3-kinase and atypical protein kinase Cs (aPKCs) while stimulating glucose transport in 3T3/L1 adipocytes.	Glucose	219-226	Cbl proto-oncogene	Homo sapiens	113-116
14640702-2	2003	Presently, the role of Cbl in rosiglitazone action was further assessed in both 3T3/L1 and human adipocytes by expressing Y371F and/or Y731F mutant forms of Cbl that nullified the functionality of canonical pYXXM motifs in Cbl.	Rosiglitazone	30-43	Cbl proto-oncogene	Homo sapiens	23-26
14640702-3	2003	These mutants diminished the interaction of Cbl with the p85 subunit of PI 3-kinase and inhibited subsequent increases in Cbl-dependent PI 3-kinase activity, aPKC activity, and glucose transport.	Glucose	177-184	Cbl proto-oncogene	Homo sapiens	44-47
14640702-3	2003	These mutants diminished the interaction of Cbl with the p85 subunit of PI 3-kinase and inhibited subsequent increases in Cbl-dependent PI 3-kinase activity, aPKC activity, and glucose transport.	Glucose	177-184	Cbl proto-oncogene	Homo sapiens	122-125
14640702-5	2003	We conclude that pYXXM motifs in Cbl serve to activate PI 3-kinase-dependent and possibly PI 3-kinase-independent pathways that are required for TZD-dependent glucose transport in adipocytes.	2,4-thiazolidinedione	145-148	Cbl proto-oncogene	Homo sapiens	33-36
14640702-5	2003	We conclude that pYXXM motifs in Cbl serve to activate PI 3-kinase-dependent and possibly PI 3-kinase-independent pathways that are required for TZD-dependent glucose transport in adipocytes.	Glucose	159-166	Cbl proto-oncogene	Homo sapiens	33-36
14604282-4	2003	Imatinib mesylate remarkably reduced tyrosine phosphorylation of Bcr-Abl, Cbl, and Crkl in a time-dependent manner, and their complex formation also was affected.	Imatinib Mesylate	0-17	Cbl proto-oncogene	Homo sapiens	74-77
14690593-1	2003	The adaptor protein APS is a substrate of the insulin receptor and couples receptor activation with phosphorylation of Cbl to facilitate glucose uptake.	Glucose	137-144	Cbl proto-oncogene	Homo sapiens	119-122
14585370-7	2003	Immunoblotting, immunoprecipitation, and the electrophoretic mobility shift assay were performed to detect tyrosine phosphorylation of c-Cbl, c-Jun nuclear translocation, and AP-1 DNA binding.	Tyrosine	107-115	Cbl proto-oncogene	Homo sapiens	135-140
14585370-9	2003	Tyrosine phosphorylation of c-Cbl, together with tyrosine phosphorylation of multiple protein substrates, was also induced.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	28-33
12881521-6	2003	We demonstrate that the Cbl-dependent ubiquitinylation of Vav requires Cbl/Vav association through phosphorylated Tyr-700 on Cbl, and also requires an intact Cbl RING finger domain.	Tyrosine	114-117	Cbl proto-oncogene	Homo sapiens	24-27
12881521-6	2003	We demonstrate that the Cbl-dependent ubiquitinylation of Vav requires Cbl/Vav association through phosphorylated Tyr-700 on Cbl, and also requires an intact Cbl RING finger domain.	Tyrosine	114-117	Cbl proto-oncogene	Homo sapiens	71-74
12881521-6	2003	We demonstrate that the Cbl-dependent ubiquitinylation of Vav requires Cbl/Vav association through phosphorylated Tyr-700 on Cbl, and also requires an intact Cbl RING finger domain.	Tyrosine	114-117	Cbl proto-oncogene	Homo sapiens	71-74
12881521-6	2003	We demonstrate that the Cbl-dependent ubiquitinylation of Vav requires Cbl/Vav association through phosphorylated Tyr-700 on Cbl, and also requires an intact Cbl RING finger domain.	Tyrosine	114-117	Cbl proto-oncogene	Homo sapiens	71-74
14511371-6	2003	However, arsenite-treatment did induce tyrosine-phosphorylation of c-Cbl.	arsenite	9-17	Cbl proto-oncogene	Homo sapiens	67-72
14511371-6	2003	However, arsenite-treatment did induce tyrosine-phosphorylation of c-Cbl.	Tyrosine	39-47	Cbl proto-oncogene	Homo sapiens	67-72
14511371-12	2003	This response to arsenite is not functionally linked to early steps of the IR-IRS-PI-3" kinase pathway, but does coincide with c-Cbl phosphorylation, basal levels of PKC-lambda activity and p38 MAPK activation.	arsenite	17-25	Cbl proto-oncogene	Homo sapiens	127-132
14530346-4	2003	In this study, we identified two Tyr-phosphorylated proteins, c-Cbl (Casitas B-lineage lymphoma) and Grb2-associated binder 2 (Gab2), as PI 3-kinase adaptors that are Tyr phosphorylated upon the stimulation of FcgammaRII in differentiated neutrophil-like THP-1 cells.	Tyrosine	33-36	Cbl proto-oncogene	Homo sapiens	62-67
14530346-4	2003	In this study, we identified two Tyr-phosphorylated proteins, c-Cbl (Casitas B-lineage lymphoma) and Grb2-associated binder 2 (Gab2), as PI 3-kinase adaptors that are Tyr phosphorylated upon the stimulation of FcgammaRII in differentiated neutrophil-like THP-1 cells.	Tyrosine	167-170	Cbl proto-oncogene	Homo sapiens	62-67
12874286-0	2003	Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.	Proline	26-33	Cbl proto-oncogene	Homo sapiens	91-94
12874286-0	2003	Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.	Arginine	34-42	Cbl proto-oncogene	Homo sapiens	91-94
12874286-4	2003	This motif was indispensable for CIN85 binding to Cbl/Cbl-b, to other CIN85 SH3 domains" effectors, and for mediating an intramolecular interaction between the SH3-A domain and the proline-rich region of CIN85.	Proline	181-188	Cbl proto-oncogene	Homo sapiens	50-53
12881518-1	2003	We have previously demonstrated the anti-tumor activity of nitrosylcobalamin (NO-Cbl), an analog of vitamin B12 that delivers nitric oxide (NO) and increases the expression of tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) and its receptors in human tumors.	nitrosylcobalamin	59-76	Cbl proto-oncogene	Homo sapiens	81-84
12881518-1	2003	We have previously demonstrated the anti-tumor activity of nitrosylcobalamin (NO-Cbl), an analog of vitamin B12 that delivers nitric oxide (NO) and increases the expression of tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) and its receptors in human tumors.	Vitamin B 12	100-111	Cbl proto-oncogene	Homo sapiens	81-84
12881518-1	2003	We have previously demonstrated the anti-tumor activity of nitrosylcobalamin (NO-Cbl), an analog of vitamin B12 that delivers nitric oxide (NO) and increases the expression of tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) and its receptors in human tumors.	Nitric Oxide	126-138	Cbl proto-oncogene	Homo sapiens	81-84
14604282-4	2003	Imatinib mesylate remarkably reduced tyrosine phosphorylation of Bcr-Abl, Cbl, and Crkl in a time-dependent manner, and their complex formation also was affected.	Tyrosine	37-45	Cbl proto-oncogene	Homo sapiens	74-77
12842890-0	2003	The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport.	Glucose	51-58	Cbl proto-oncogene	Homo sapiens	23-28
12842890-1	2003	Previous studies suggest that the stimulation of glucose transport by insulin involves the tyrosine phosphorylation of c-Cbl and the translocation of the c-Cbl/CAP complex to lipid raft subdomains of the plasma membrane.	Glucose	49-56	Cbl proto-oncogene	Homo sapiens	119-124
12842890-1	2003	Previous studies suggest that the stimulation of glucose transport by insulin involves the tyrosine phosphorylation of c-Cbl and the translocation of the c-Cbl/CAP complex to lipid raft subdomains of the plasma membrane.	Glucose	49-56	Cbl proto-oncogene	Homo sapiens	154-159
12842890-1	2003	Previous studies suggest that the stimulation of glucose transport by insulin involves the tyrosine phosphorylation of c-Cbl and the translocation of the c-Cbl/CAP complex to lipid raft subdomains of the plasma membrane.	Tyrosine	91-99	Cbl proto-oncogene	Homo sapiens	119-124
12842890-4	2003	The phosphorylation of APS produced by insulin drove the translocation of both c-Cbl and Cbl-b to the plasma membrane.	Adenosine Phosphosulfate	23-26	Cbl proto-oncogene	Homo sapiens	79-84
12842890-7	2003	A Cbl mutant incapable of dimerization failed to interact with APS and to undergo tyrosine phosphorylation in response to insulin, indicating an essential role of Cbl dimerization in these processes.	Adenosine Phosphosulfate	63-66	Cbl proto-oncogene	Homo sapiens	2-5
12842890-7	2003	A Cbl mutant incapable of dimerization failed to interact with APS and to undergo tyrosine phosphorylation in response to insulin, indicating an essential role of Cbl dimerization in these processes.	Tyrosine	82-90	Cbl proto-oncogene	Homo sapiens	2-5
12842890-8	2003	Thus, both c-Cbl and Cbl-b can initiate a phosphatidylinositol 3-kinase/protein kinase B-independent signaling pathway critical to insulin-stimulated GLUT4 translocation.	Phosphatidylinositols	42-62	Cbl proto-oncogene	Homo sapiens	11-16
12915106-8	2003	PD153035 abolished EGF-induced phosphorylation of the EGFR substrate Cbl, but had no effect on levels of phospho-Cbl caused by Zn(2+).	4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline	0-8	Cbl proto-oncogene	Homo sapiens	69-72
12941616-2	2003	Analysis of site-specific c-Cbl mutants indicated that tyrosine phosphorylation of c-Cbl was required for down-regulation of the PLCgamma1/Ca2+ pathway.	Tyrosine	55-63	Cbl proto-oncogene	Homo sapiens	26-31
12941616-2	2003	Analysis of site-specific c-Cbl mutants indicated that tyrosine phosphorylation of c-Cbl was required for down-regulation of the PLCgamma1/Ca2+ pathway.	Tyrosine	55-63	Cbl proto-oncogene	Homo sapiens	83-88
12941616-4	2003	Additional data indicate that the SH3 domain of PLCgamma1 binds to both canonical and noncanonical SH3 domain-binding sites in the proline-rich region of c-Cbl.	Proline	131-138	Cbl proto-oncogene	Homo sapiens	154-159
12839496-5	2003	Localization of Cbl-yellow fluorescent protein to these endocytic organelles was dependent on a proline-rich domain of c-Cbl that interacts with Grb2 as shown by fluorescence resonance energy transfer microscopy.	Proline	96-103	Cbl proto-oncogene	Homo sapiens	16-19
12923257-4	2003	In analogy to the model of regulation of the riboflavin and thiamin biosynthesis, we suggest Ado-CBL-mediated regulation based on formation of alternative RNA structures including the B12-element.	Riboflavin	45-55	Cbl proto-oncogene	Homo sapiens	97-100
12923257-4	2003	In analogy to the model of regulation of the riboflavin and thiamin biosynthesis, we suggest Ado-CBL-mediated regulation based on formation of alternative RNA structures including the B12-element.	Thiamine	60-67	Cbl proto-oncogene	Homo sapiens	97-100
12939720-9	2003	Daclizumab, infliximab, visilizumab, and ABX-CBL have shown promising activity in steroid-resistant acute GvHD in early clinical testing.	Steroids	82-89	Cbl proto-oncogene	Homo sapiens	45-48
12873151-1	2003	Despite early claims that nitric oxide does not react with cobalamin under any circumstances, it is now accepted that NO has a high affinity for cobalamin in the 2+ oxidation state [Cbl(II)].	Vitamin B 12	145-154	Cbl proto-oncogene	Homo sapiens	182-185
12873151-12	2003	Interestingly, Cbi(II) has 100 times greater affinity for NO than does Cbl(II), proving that there is a strong trans effect due to the tethered base in nitrosyl derivatives of both Cbl(II) and Cbl(III).	cobinamide	15-18	Cbl proto-oncogene	Homo sapiens	181-184
12815057-0	2003	Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	67-72
12815057-3	2003	In this study it is demonstrated that hSpry2 is tyrosine-phosphorylated upon stimulation by either FGFR or EGF and subsequently binds endogenous c-Cbl with high affinity.	Tyrosine	48-56	Cbl proto-oncogene	Homo sapiens	145-150
12815057-4	2003	A conserved motif on hSpry2, together with phosphorylation on tyrosine 55, is required for its enhanced interaction with the SH2-like domain of c-Cbl.	Tyrosine	62-70	Cbl proto-oncogene	Homo sapiens	144-149
12815057-6	2003	Furthermore, individually mutating hSpry2 residues 52-59 to alanine indicated a tight correlation between their affinity for c-Cbl binding and their inhibition of ERK2 activity in the FGFR pathway.	Alanine	60-67	Cbl proto-oncogene	Homo sapiens	125-130
12815057-7	2003	We postulate that tyrosine phosphorylation "activates" hSpry2 by enhancing its interaction with c-Cbl and that this interaction is critical for its physiological function in a signal-specific context.	Tyrosine	18-26	Cbl proto-oncogene	Homo sapiens	96-101
12873151-12	2003	Interestingly, Cbi(II) has 100 times greater affinity for NO than does Cbl(II), proving that there is a strong trans effect due to the tethered base in nitrosyl derivatives of both Cbl(II) and Cbl(III).	cobinamide	15-18	Cbl proto-oncogene	Homo sapiens	181-184
12839496-5	2003	Localization of Cbl-yellow fluorescent protein to these endocytic organelles was dependent on a proline-rich domain of c-Cbl that interacts with Grb2 as shown by fluorescence resonance energy transfer microscopy.	Proline	96-103	Cbl proto-oncogene	Homo sapiens	119-124
12839496-6	2003	In contrast, direct binding of Cbl to phosphotyrosine 1045 of the epidermal growth factor receptor was required for epidermal growth factor receptor polyubiquitination, but was not essential for Cbl-yellow fluorescent protein localization in epidermal growth factor receptor-containing compartments.	Phosphotyrosine	38-53	Cbl proto-oncogene	Homo sapiens	31-34
12794130-6	2003	Induction of Cbl phosphorylation upon EphA activation appeared to be dependent upon Src family kinase activity, as Cbl phosphorylation was selectively abrogated by the Src family inhibitor 4-amino-5(4-chlorophenyl-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine, while EphA phosphorylation was unimpaired.	4-amino-5(4-chlorophenyl-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine	189-253	Cbl proto-oncogene	Homo sapiens	13-16
12898421-7	2003	Taken together, these results suggest that rosmarinic acid has the potential to specifically inhibit Lck SH2 domain binding to its cognate ligand, including ZAP-70, Cbl, HS-1, and PLCgamma1, and Lck-dependent Ca 2+ signaling pathway of its downstream effector and finally to modulate IL-2 gene expression after T cell activation.	rosmarinic acid	43-58	Cbl proto-oncogene	Homo sapiens	165-168
12794130-6	2003	Induction of Cbl phosphorylation upon EphA activation appeared to be dependent upon Src family kinase activity, as Cbl phosphorylation was selectively abrogated by the Src family inhibitor 4-amino-5(4-chlorophenyl-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine, while EphA phosphorylation was unimpaired.	4-amino-5(4-chlorophenyl-7-(tert-butyl)pyrazolo[3,4-d]pyrimidine	189-253	Cbl proto-oncogene	Homo sapiens	115-118
12802274-4	2003	Both the phosphotyrosine binding domain of c-Cbl and its RING domain are essential for downregulation of Ron.	Phosphotyrosine	9-24	Cbl proto-oncogene	Homo sapiens	43-48
12696071-9	2003	CBL, a proto-oncogene, functions as a negative regulator of several receptor protein-tyrosine-kinase signaling pathways and as an adaptor protein in tyrosine phosphorylation-dependent signaling.	Tyrosine	85-93	Cbl proto-oncogene	Homo sapiens	0-3
12644458-6	2003	Furthermore, high glucose down-regulated the expression of CAP and Cbl, and insulin-stimulated Cbl phosphorylation, components of an insulin signaling cascade previously characterized in adipocytes.	Glucose	18-25	Cbl proto-oncogene	Homo sapiens	67-70
12644458-7	2003	These data suggest that high glucose specifically inhibits insulin-stimulated NO synthesis and down-regulates some aspects of insulin signaling, including the CAP-Cbl signaling pathway, yet this is not a result of reduced PKB-mediated eNOS phosphorylation at Ser1177.	Glucose	29-36	Cbl proto-oncogene	Homo sapiens	163-166
19966925-4	2002	By analyzing CHO-TS20 cells with a temperature-sensitive ubiquitin activating enzyme, we demonstrate that intact cellular ubiquitin machinery is required for Cbl-induced degradation of Fyn.	CAV protocol	13-16	Cbl proto-oncogene	Homo sapiens	158-161
12717426-3	2003	70Z/3 Cbl-induced PLC gamma 1 tyrosine phosphorylation required, in addition to the PLC gamma 1 N-terminal SH2 domain, the C-terminal SH2 and SH3 domains that were dispensable for TCR-induced phosphorylation.	Tyrosine	30-38	Cbl proto-oncogene	Homo sapiens	6-9
12604776-4	2003	In response to activation of c-Src, c-Cbl proteins undergo tyrosine phosphorylation that promotes their ubiquitylation and proteasomal destruction.	Tyrosine	59-67	Cbl proto-oncogene	Homo sapiens	36-41
12435267-2	2003	In the present study, we report Src kinase-dependent beta(2) integrin-induced tyrosine phosphorylation of Cbl occurring in parallel with increased Cbl-associated tyrosine kinase activity.	Tyrosine	78-86	Cbl proto-oncogene	Homo sapiens	106-109
12435267-6	2003	The following observations imply that Syk is such a kinase: (i) beta(2) integrins activated Syk in a Src-dependent manner, (ii) Syk was associated with Cbl much longer than Fgr was, and (iii) the Syk inhibitor piceatannol (3,4,3",5"-tetrahydroxy- trans -stilbene) abolished the Cbl-associated kinase activity in an in vitro assay.	3,3',4,5'-tetrahydroxystilbene	210-221	Cbl proto-oncogene	Homo sapiens	152-155
12435267-6	2003	The following observations imply that Syk is such a kinase: (i) beta(2) integrins activated Syk in a Src-dependent manner, (ii) Syk was associated with Cbl much longer than Fgr was, and (iii) the Syk inhibitor piceatannol (3,4,3",5"-tetrahydroxy- trans -stilbene) abolished the Cbl-associated kinase activity in an in vitro assay.	3,3',4,5'-tetrahydroxystilbene	210-221	Cbl proto-oncogene	Homo sapiens	278-281
12435267-6	2003	The following observations imply that Syk is such a kinase: (i) beta(2) integrins activated Syk in a Src-dependent manner, (ii) Syk was associated with Cbl much longer than Fgr was, and (iii) the Syk inhibitor piceatannol (3,4,3",5"-tetrahydroxy- trans -stilbene) abolished the Cbl-associated kinase activity in an in vitro assay.	3,3',4,5'-tetrahydroxystilbene	223-262	Cbl proto-oncogene	Homo sapiens	152-155
12435267-6	2003	The following observations imply that Syk is such a kinase: (i) beta(2) integrins activated Syk in a Src-dependent manner, (ii) Syk was associated with Cbl much longer than Fgr was, and (iii) the Syk inhibitor piceatannol (3,4,3",5"-tetrahydroxy- trans -stilbene) abolished the Cbl-associated kinase activity in an in vitro assay.	3,3',4,5'-tetrahydroxystilbene	223-262	Cbl proto-oncogene	Homo sapiens	278-281
12553836-1	2003	The electron-transfer reaction between reduced cobalamin (Cbl(II)) and sodium pentacyanonitrosylferrate(II) (sodium nitroprusside, NP), as well as the subsequent processes following the electron-transfer step, were investigated by spectroscopic (UV-vis, (1)H NMR, EPR), electrochemical (CV, DPV) and kinetic (stopped-flow) techniques.	Vitamin B 12	47-56	Cbl proto-oncogene	Homo sapiens	58-61
12553836-1	2003	The electron-transfer reaction between reduced cobalamin (Cbl(II)) and sodium pentacyanonitrosylferrate(II) (sodium nitroprusside, NP), as well as the subsequent processes following the electron-transfer step, were investigated by spectroscopic (UV-vis, (1)H NMR, EPR), electrochemical (CV, DPV) and kinetic (stopped-flow) techniques.	Nitroprusside	109-129	Cbl proto-oncogene	Homo sapiens	58-61
12553836-7	2003	At low pH and total NP concentration (pH &lt; 3, [NP]/[Cbl(II)] approximately 1), the cyano-bridged successor complex [Cbl(III)-(mu-NC)-Fe(I)(CN)(3)(NO(+))](-) (1(s)()) is the final reaction product formed in an inner-sphere electron transfer reaction that is coupled to the release of cyanide from coordinated nitroprusside.	Cyanides	286-293	Cbl proto-oncogene	Homo sapiens	119-122
12553836-7	2003	At low pH and total NP concentration (pH &lt; 3, [NP]/[Cbl(II)] approximately 1), the cyano-bridged successor complex [Cbl(III)-(mu-NC)-Fe(I)(CN)(3)(NO(+))](-) (1(s)()) is the final reaction product formed in an inner-sphere electron transfer reaction that is coupled to the release of cyanide from coordinated nitroprusside.	Nitroprusside	311-324	Cbl proto-oncogene	Homo sapiens	119-122
12553836-8	2003	At higher pH, subsequent reactions were observed which involve the attack of cyanide released in the electron transfer step on the initially formed cyano-bridged species, and lead to the formation of Cbl(III)CN and [Fe(I)(CN)(4)(NO(+))](2)(-).	Cyanides	77-84	Cbl proto-oncogene	Homo sapiens	200-203
12553836-14	2003	In addition, the release of NO resulting from the one-electron reduction of NP by Cbl(II) was monitored with the use of a sensitive NO electrode.	Neptunium	76-78	Cbl proto-oncogene	Homo sapiens	82-85
12606547-5	2003	Furthermore, epidermal growth factor-induced activation of Src and phosphorylation of the Src substrates Cbl and focal adhesion kinase are inhibited by activation of the cAMP-PKA-Csk pathway.	Cyclic AMP	170-174	Cbl proto-oncogene	Homo sapiens	105-108
12671687-6	2003	Remarkably, the membrane translocation of C3G, its association with CrkL, and the guanine-nucleotide exchange activity of C3G were all increased in Cbl(-/-) thymocytes.	Guanine Nucleotides	82-100	Cbl proto-oncogene	Homo sapiens	148-151
12618476-6	2003	CIN85 SH3A and CIN85/CD2BP3 SH3B bind to proline-rich segments within CIN85/CD2BP3 themselves as evidenced by mAb accessibility analysis and protein interaction studies including c-Cbl binding.	Proline	41-48	Cbl proto-oncogene	Homo sapiens	179-184
12593795-6	2003	Upon activation of the receptor for the epidermal growth factor (EGFR), Sprouty2 undergoes phosphorylation at a conserved tyrosine that recruits the Src homology 2 domain of c-Cbl.	Tyrosine	122-130	Cbl proto-oncogene	Homo sapiens	174-179
12554972-1	2003	Results of the accurate crystal structure determination of NO(2)Cbl.2LiCl (1), NO(2)Cbl.NaCl (2), NCSCbl (3) and NCSeCbl (4), based on synchrotron diffraction data collected at 100 K, are described.	Sodium Chloride	88-92	Cbl proto-oncogene	Homo sapiens	64-69
12436329-4	2002	This pathway begins with the phosphorylation of the adaptor protein Cbl by the insulin receptor, and results in the activation of a small GTP binding protein, TC10, a member of the Rho family.	Guanosine Triphosphate	138-141	Cbl proto-oncogene	Homo sapiens	68-71
12244174-4	2002	In this study, we demonstrate that HGF induces strong tyrosine phosphorylation of the proto-oncogene product c-Cbl in B cells and increases Cbl association with the Src family tyrosine kinases Fyn and Lyn, as well as with phosphatidylinositol-3 kinase and CrkL.	Tyrosine	54-62	Cbl proto-oncogene	Homo sapiens	109-114
12244174-4	2002	In this study, we demonstrate that HGF induces strong tyrosine phosphorylation of the proto-oncogene product c-Cbl in B cells and increases Cbl association with the Src family tyrosine kinases Fyn and Lyn, as well as with phosphatidylinositol-3 kinase and CrkL.	Tyrosine	54-62	Cbl proto-oncogene	Homo sapiens	111-114
11964172-5	2002	Grb2-SH3 domains formed an association with the proline-rich sequences of Sos and Cbl in both resting and activated platelets, since the peptidimer abolished these associations.	Proline	48-55	Cbl proto-oncogene	Homo sapiens	82-85
12147253-5	2002	The dominant negative mutant 70Z-Cbl, which has a 17-amino acids deletion in the N-boundary of the RING finger domain, defuncted negative regulatory function of Cbl to EphA2.	17-amino acids	50-64	Cbl proto-oncogene	Homo sapiens	33-36
12147253-5	2002	The dominant negative mutant 70Z-Cbl, which has a 17-amino acids deletion in the N-boundary of the RING finger domain, defuncted negative regulatory function of Cbl to EphA2.	17-amino acids	50-64	Cbl proto-oncogene	Homo sapiens	161-164
12094251-6	2002	FcgammaRIIA ligation in RS4;11 and 380 cells induced tyrosine phosphorylation of CD32, CD19, CBL, SYK, P13-K p85 and SHIP, as well as RasGAP association with tyrosine-phosphorylated p62(dok).	Tyrosine	53-61	Cbl proto-oncogene	Homo sapiens	93-96
12024036-5	2002	Following stimulation of primary thymocytes with anti-CD3 and anti-CD28, SLAP-2 coimmunoprecipitates with tyrosine-phosphorylated c-Cbl and an unidentified protein of approximately 72 kDa.	Tyrosine	106-114	Cbl proto-oncogene	Homo sapiens	130-135
11997436-3	2002	Here, we demonstrate that Grb2 bound to tyrosine-phosphorylated FRS2 alpha forms a ternary complex with Cbl by means of its Src homology 3 domains resulting in the ubiquitination of fibroblast growth factor (FGF) receptor and FRS2 alpha in response to FGF stimulation.	Tyrosine	40-48	Cbl proto-oncogene	Homo sapiens	104-107
11978125-1	2002	Electrochemistry and Raman spectroscopy have shown that aquocob(III)alamin (Cbl(III)) can be reduced by nitric oxide (NO) to form Cbl(II) on an electrode surface.	Nitric Oxide	104-116	Cbl proto-oncogene	Homo sapiens	64-67
11978125-1	2002	Electrochemistry and Raman spectroscopy have shown that aquocob(III)alamin (Cbl(III)) can be reduced by nitric oxide (NO) to form Cbl(II) on an electrode surface.	Nitric Oxide	104-116	Cbl proto-oncogene	Homo sapiens	76-84
11978125-1	2002	Electrochemistry and Raman spectroscopy have shown that aquocob(III)alamin (Cbl(III)) can be reduced by nitric oxide (NO) to form Cbl(II) on an electrode surface.	Nitric Oxide	104-116	Cbl proto-oncogene	Homo sapiens	76-79
11978125-2	2002	The Cbl(II) formed in this way can bind NO to form nitrosyl-cobalamin, Cbl(II)-NO, which is reduced to form Cbl(I) at about -1.0 V vs a KCl saturated Ag/AgCl reference electrode.	nitrosylcobalamin	51-69	Cbl proto-oncogene	Homo sapiens	4-7
11978125-2	2002	The Cbl(II) formed in this way can bind NO to form nitrosyl-cobalamin, Cbl(II)-NO, which is reduced to form Cbl(I) at about -1.0 V vs a KCl saturated Ag/AgCl reference electrode.	nitrosylcobalamin	51-69	Cbl proto-oncogene	Homo sapiens	71-81
11978125-2	2002	The Cbl(II) formed in this way can bind NO to form nitrosyl-cobalamin, Cbl(II)-NO, which is reduced to form Cbl(I) at about -1.0 V vs a KCl saturated Ag/AgCl reference electrode.	nitrosylcobalamin	51-69	Cbl proto-oncogene	Homo sapiens	71-74
11978125-2	2002	The Cbl(II) formed in this way can bind NO to form nitrosyl-cobalamin, Cbl(II)-NO, which is reduced to form Cbl(I) at about -1.0 V vs a KCl saturated Ag/AgCl reference electrode.	Potassium Chloride	136-139	Cbl proto-oncogene	Homo sapiens	4-7
11978125-2	2002	The Cbl(II) formed in this way can bind NO to form nitrosyl-cobalamin, Cbl(II)-NO, which is reduced to form Cbl(I) at about -1.0 V vs a KCl saturated Ag/AgCl reference electrode.	Potassium Chloride	136-139	Cbl proto-oncogene	Homo sapiens	71-81
11978125-2	2002	The Cbl(II) formed in this way can bind NO to form nitrosyl-cobalamin, Cbl(II)-NO, which is reduced to form Cbl(I) at about -1.0 V vs a KCl saturated Ag/AgCl reference electrode.	Potassium Chloride	136-139	Cbl proto-oncogene	Homo sapiens	71-74
11978125-2	2002	The Cbl(II) formed in this way can bind NO to form nitrosyl-cobalamin, Cbl(II)-NO, which is reduced to form Cbl(I) at about -1.0 V vs a KCl saturated Ag/AgCl reference electrode.	silver chloride	153-157	Cbl proto-oncogene	Homo sapiens	4-7
11978125-2	2002	The Cbl(II) formed in this way can bind NO to form nitrosyl-cobalamin, Cbl(II)-NO, which is reduced to form Cbl(I) at about -1.0 V vs a KCl saturated Ag/AgCl reference electrode.	silver chloride	153-157	Cbl proto-oncogene	Homo sapiens	71-81
11978125-2	2002	The Cbl(II) formed in this way can bind NO to form nitrosyl-cobalamin, Cbl(II)-NO, which is reduced to form Cbl(I) at about -1.0 V vs a KCl saturated Ag/AgCl reference electrode.	silver chloride	153-157	Cbl proto-oncogene	Homo sapiens	71-74
11978125-3	2002	In addition, nitrite was found to bind both Cbl(III) and Cbl(II) and a binding constant of 3.5 x 10(2) M(-1) was measured for (NO(2)-Cbl(II))(1-).	Nitrites	13-20	Cbl proto-oncogene	Homo sapiens	44-47
11978125-3	2002	In addition, nitrite was found to bind both Cbl(III) and Cbl(II) and a binding constant of 3.5 x 10(2) M(-1) was measured for (NO(2)-Cbl(II))(1-).	Nitrites	13-20	Cbl proto-oncogene	Homo sapiens	48-51
11978125-3	2002	In addition, nitrite was found to bind both Cbl(III) and Cbl(II) and a binding constant of 3.5 x 10(2) M(-1) was measured for (NO(2)-Cbl(II))(1-).	Nitrites	13-20	Cbl proto-oncogene	Homo sapiens	57-60
11978125-3	2002	In addition, nitrite was found to bind both Cbl(III) and Cbl(II) and a binding constant of 3.5 x 10(2) M(-1) was measured for (NO(2)-Cbl(II))(1-).	Nitrites	13-20	Cbl proto-oncogene	Homo sapiens	57-60
12063263-5	2002	Importantly, H(2)O(2) generates a receptor with negligible phosphorylation at tyrosine 1045, the major docking site for the ubiquitin ligase c-Cbl.	Hydrogen Peroxide	13-21	Cbl proto-oncogene	Homo sapiens	141-146
12021520-2	2002	methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fasting tHcy levels in hemodialysis (HD) patients.	Vitamin B 12	61-72	Cbl proto-oncogene	Homo sapiens	20-23
11978125-4	2002	UV-vis spectrophotometry and mass spectroscopy were used to show that Cbl(I) reduces NO to form Cbl(II)-NO and N(2)O and N(2), and this reaction is involved in the cyclic voltammetry of cobalamin in the presence of excess NO where a catalytic reduction of NO occurs involving the cycling of Cbl(II)-NO/Cbl(I).	Nitrous Oxide	111-116	Cbl proto-oncogene	Homo sapiens	70-73
11978125-4	2002	UV-vis spectrophotometry and mass spectroscopy were used to show that Cbl(I) reduces NO to form Cbl(II)-NO and N(2)O and N(2), and this reaction is involved in the cyclic voltammetry of cobalamin in the presence of excess NO where a catalytic reduction of NO occurs involving the cycling of Cbl(II)-NO/Cbl(I).	Nitrous Oxide	111-116	Cbl proto-oncogene	Homo sapiens	291-301
11978125-4	2002	UV-vis spectrophotometry and mass spectroscopy were used to show that Cbl(I) reduces NO to form Cbl(II)-NO and N(2)O and N(2), and this reaction is involved in the cyclic voltammetry of cobalamin in the presence of excess NO where a catalytic reduction of NO occurs involving the cycling of Cbl(II)-NO/Cbl(I).	Nitrogen	111-115	Cbl proto-oncogene	Homo sapiens	70-73
11978125-4	2002	UV-vis spectrophotometry and mass spectroscopy were used to show that Cbl(I) reduces NO to form Cbl(II)-NO and N(2)O and N(2), and this reaction is involved in the cyclic voltammetry of cobalamin in the presence of excess NO where a catalytic reduction of NO occurs involving the cycling of Cbl(II)-NO/Cbl(I).	Nitrogen	111-115	Cbl proto-oncogene	Homo sapiens	291-301
11978125-4	2002	UV-vis spectrophotometry and mass spectroscopy were used to show that Cbl(I) reduces NO to form Cbl(II)-NO and N(2)O and N(2), and this reaction is involved in the cyclic voltammetry of cobalamin in the presence of excess NO where a catalytic reduction of NO occurs involving the cycling of Cbl(II)-NO/Cbl(I).	Vitamin B 12	186-195	Cbl proto-oncogene	Homo sapiens	70-73
11978125-4	2002	UV-vis spectrophotometry and mass spectroscopy were used to show that Cbl(I) reduces NO to form Cbl(II)-NO and N(2)O and N(2), and this reaction is involved in the cyclic voltammetry of cobalamin in the presence of excess NO where a catalytic reduction of NO occurs involving the cycling of Cbl(II)-NO/Cbl(I).	Vitamin B 12	186-195	Cbl proto-oncogene	Homo sapiens	96-106
11978125-4	2002	UV-vis spectrophotometry and mass spectroscopy were used to show that Cbl(I) reduces NO to form Cbl(II)-NO and N(2)O and N(2), and this reaction is involved in the cyclic voltammetry of cobalamin in the presence of excess NO where a catalytic reduction of NO occurs involving the cycling of Cbl(II)-NO/Cbl(I).	Vitamin B 12	186-195	Cbl proto-oncogene	Homo sapiens	291-301
11978125-4	2002	UV-vis spectrophotometry and mass spectroscopy were used to show that Cbl(I) reduces NO to form Cbl(II)-NO and N(2)O and N(2), and this reaction is involved in the cyclic voltammetry of cobalamin in the presence of excess NO where a catalytic reduction of NO occurs involving the cycling of Cbl(II)-NO/Cbl(I).	Vitamin B 12	186-195	Cbl proto-oncogene	Homo sapiens	96-99
11970992-4	2002	Furthermore, FcR nonbinding anti-CD3 mAbs induced tyrosine phosphorylation of the Fyn substrate Cbl, but not the ZAP-70 substrate linker for activation of T cells.	Tyrosine	50-58	Cbl proto-oncogene	Homo sapiens	96-99
12021520-2	2002	methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fasting tHcy levels in hemodialysis (HD) patients.	mecobalamin	0-15	Cbl proto-oncogene	Homo sapiens	20-23
12021520-2	2002	methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fasting tHcy levels in hemodialysis (HD) patients.	Homocysteine	148-160	Cbl proto-oncogene	Homo sapiens	20-23
12021520-2	2002	methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fasting tHcy levels in hemodialysis (HD) patients.	thcy	162-166	Cbl proto-oncogene	Homo sapiens	20-23
12021520-2	2002	methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fasting tHcy levels in hemodialysis (HD) patients.	Methionine	101-111	Cbl proto-oncogene	Homo sapiens	20-23
12021520-2	2002	methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fasting tHcy levels in hemodialysis (HD) patients.	Folic Acid	204-214	Cbl proto-oncogene	Homo sapiens	20-23
12021520-2	2002	methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fasting tHcy levels in hemodialysis (HD) patients.	thcy	248-252	Cbl proto-oncogene	Homo sapiens	20-23
11788601-1	2002	Changes in the absorbance spectrum of aquo-cobalamin (Cbl x OH(2)) revealed that its binding to transcobalamin (TC) is followed by slow conformational reorganization of the protein-ligand complex (Fedosov, S. N., Fedosova, N. U., Nexo, E., and Petersen, T. E. (2000) J. Biol.	aquacobalamin	38-52	Cbl proto-oncogene	Homo sapiens	54-57
11788601-4	2002	Two phases were also observed for TC when interacting with a Cbl-analogue cobinamide (Cbi), but not with other cobalamins.	cobinamide	74-84	Cbl proto-oncogene	Homo sapiens	61-64
11788601-4	2002	Two phases were also observed for TC when interacting with a Cbl-analogue cobinamide (Cbi), but not with other cobalamins.	cobinamide	86-89	Cbl proto-oncogene	Homo sapiens	61-64
11788601-6	2002	Spectral transformations observed for TC in the slow phase were similar to those upon histidine complexation with Cbl x OH(2) and Cbi.	Histidine	86-95	Cbl proto-oncogene	Homo sapiens	114-117
11788601-8	2002	The binders decreased sensitivity of adenosyl-Cbl (Cbl x Ado) to light in the range: free ligand, IF x, HC x, TC x Cbl x Ado.	Acetaminophen	55-56	Cbl proto-oncogene	Homo sapiens	46-49
11788601-8	2002	The binders decreased sensitivity of adenosyl-Cbl (Cbl x Ado) to light in the range: free ligand, IF x, HC x, TC x Cbl x Ado.	Acetaminophen	55-56	Cbl proto-oncogene	Homo sapiens	51-54
11788601-8	2002	The binders decreased sensitivity of adenosyl-Cbl (Cbl x Ado) to light in the range: free ligand, IF x, HC x, TC x Cbl x Ado.	Acetaminophen	55-56	Cbl proto-oncogene	Homo sapiens	51-54
11788601-10	2002	The above data suggest presence of a histidine-containing cap shielding the Cbl-binding site in TC.	Histidine	37-46	Cbl proto-oncogene	Homo sapiens	76-79
11788601-11	2002	The cap coordinates to certain corrinoids and, possibly, produces an incapsulated Ado-radical when Cbl small middle dotAdo is bound.	Corrinoids	31-41	Cbl proto-oncogene	Homo sapiens	99-102
11788601-11	2002	The cap coordinates to certain corrinoids and, possibly, produces an incapsulated Ado-radical when Cbl small middle dotAdo is bound.	ado-radical	82-93	Cbl proto-oncogene	Homo sapiens	99-102
11777909-5	2002	This finding was supported by the observation that the transmembrane form of Notch1 was tyrosine-phosphorylated and specifically coprecipitated with the ubiquitin ligase c-Cbl.	Tyrosine	88-96	Cbl proto-oncogene	Homo sapiens	170-175
12064907-1	2002	Transcobalamin II (TCII) is a plasma protein essential for the transport and cellular uptake of vitamin B12 (B12; cobalamin, Cbl).	Vitamin B 12	96-107	Cbl proto-oncogene	Homo sapiens	125-128
12064907-1	2002	Transcobalamin II (TCII) is a plasma protein essential for the transport and cellular uptake of vitamin B12 (B12; cobalamin, Cbl).	zwittergent 3-12	104-107	Cbl proto-oncogene	Homo sapiens	125-128
11850825-0	2002	C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor"s carboxy-terminus.	Tyrosine	34-42	Cbl proto-oncogene	Homo sapiens	0-5
11713248-9	2002	Although EphB6-Cbl association appeared to be constitutive, Cbl required a functional phosphotyrosine binding domain in order to bind the receptor, whereas its RING finger motif ubiquitin-transfer domain was not necessary.	Phosphotyrosine	86-101	Cbl proto-oncogene	Homo sapiens	60-63
11850825-11	2002	Our observations are consistent with a model in which receptor autophosphorylation at Tyr 973 creates a binding site for c-Cbl.	Tyrosine	86-89	Cbl proto-oncogene	Homo sapiens	121-126
11792427-6	2002	CD2 crosslinking markedly induced tyrosine phosphorylation of Cbl associated with Grb2 or CrkL, Shc and LAT, compared with IL-2 stimulation.	Tyrosine	34-42	Cbl proto-oncogene	Homo sapiens	62-65
11792427-8	2002	In vitro binding studies using GST-fusion proteins revealed that interactions of Grb2-Shc and CrkL-Cbl were mediated through each SH2 domain in tyrosine phosphorylation-dependent manner.	Tyrosine	144-152	Cbl proto-oncogene	Homo sapiens	99-102
11684286-2	2001	Addition of BsAb to normal monocytes induced tyrosine phosphorylation of Cbl and Vav, association of these molecules with CD33, and downstream signaling.	Tyrosine	45-53	Cbl proto-oncogene	Homo sapiens	73-76
11724969-3	2001	Structural analysis of the Cbl proteins shows that, in many instances, they interact with phosphorylated tyrosine residues on their targets.	Tyrosine	105-113	Cbl proto-oncogene	Homo sapiens	27-30
11724969-4	2001	Furthermore, phosphorylation of specific tyrosine residues on the Cbl proteins may provide an additional level of control on the ubiquitinating activity of these proteins.	Tyrosine	41-49	Cbl proto-oncogene	Homo sapiens	66-69
11696592-7	2001	In antigen receptor-stimulated cells, SLAP-2 associated with several tyrosine phosphorylated proteins, including the ubiquitin ligase Cbl.	Tyrosine	69-77	Cbl proto-oncogene	Homo sapiens	134-137
11698455-3	2001	In retinoic acid-differentiated HL-60 cells, cross-linking of FcgammaRs resulted in a marked increase in the tyrosine phosphorylation of FcgammaRIIa, p58(lyn), and p120(c-cbl), which was inhibited by a specific inhibitor of Src family protein tyrosine kinases.	Tretinoin	3-16	Cbl proto-oncogene	Homo sapiens	169-174
11698455-3	2001	In retinoic acid-differentiated HL-60 cells, cross-linking of FcgammaRs resulted in a marked increase in the tyrosine phosphorylation of FcgammaRIIa, p58(lyn), and p120(c-cbl), which was inhibited by a specific inhibitor of Src family protein tyrosine kinases.	Tyrosine	109-117	Cbl proto-oncogene	Homo sapiens	169-174
11698455-4	2001	After cross-linking, FcgammaRs and tyrosine-phosphorylated proteins including p120(c-cbl) were found in the low-density detergent-resistant membrane (DRM) fractions isolated by sucrose-density gradient ultracentrifugation.	Tyrosine	35-43	Cbl proto-oncogene	Homo sapiens	83-88
11698455-4	2001	After cross-linking, FcgammaRs and tyrosine-phosphorylated proteins including p120(c-cbl) were found in the low-density detergent-resistant membrane (DRM) fractions isolated by sucrose-density gradient ultracentrifugation.	Sucrose	177-184	Cbl proto-oncogene	Homo sapiens	83-88
11741535-5	2001	This tyrosine provides a direct binding site for the c-Cbl TKB domain, and is absent in the rearranged oncogenic Tpr-Met variant.	Tyrosine	5-13	Cbl proto-oncogene	Homo sapiens	53-58
11578192-3	2001	The formation constants K(CN) for the 1:1 cyanide adducts (R(CN)Cbl) were found to be 0.38 +/- 0.03, 0.43 +/- 0.03, and 123 +/- 9 M(-1) for R = Me, CH(2)Br, and CF(3), respectively.	Cyanides	42-49	Cbl proto-oncogene	Homo sapiens	64-67
11583539-1	2001	The reduced form of aquacobalamin binds nitric oxide very effectively to yield a nitrosyl adduct, Cbl(II)-NO.	Nitric Oxide	40-52	Cbl proto-oncogene	Homo sapiens	98-108
11567989-0	2001	Treatment of steroid-refractory acute graft-versus-host disease with anti-CD147 monoclonal antibody ABX-CBL.	Steroids	13-20	Cbl proto-oncogene	Homo sapiens	104-107
11418612-1	2001	The Crk adapter proteins are assumed to play a role in T lymphocyte activation because of their induced association with tyrosine-phosphorylated proteins, such as ZAP-70 and Cbl, and with the phosphatidylinositol 3kinase regulatory subunit, p85, following engagement of the T cell antigen receptor.	Tyrosine	121-129	Cbl proto-oncogene	Homo sapiens	174-177
11418612-2	2001	Although the exact mechanism of interaction between these molecules has not been fully defined, it has been generally accepted that Crk, ZAP-70, and p85 interact with tyrosine-phosphorylated Cbl, which serves as a major scaffold protein in activated T lymphocytes.	Tyrosine	167-175	Cbl proto-oncogene	Homo sapiens	191-194
11309621-4	2001	We previously described a pathway involving the insulin-stimulated tyrosine phosphorylation of Cbl, which is recruited to the insulin receptor by the adapter protein CAP.	Tyrosine	67-75	Cbl proto-oncogene	Homo sapiens	95-98
11741535-4	2001	This requires the c-Cbl tyrosine kinase binding (TKB) domain and a juxtamembrane tyrosine residue on Met.	Tyrosine	24-32	Cbl proto-oncogene	Homo sapiens	18-23
11590234-7	2001	Hrs and Cbl, which both undergo tyrosine phosphorylation in response to growth factor stimulation, are believed to influence receptor sorting in the early endosome and engage in multiple interactions, which may play a direct role in signalling cascades.	Tyrosine	32-40	Cbl proto-oncogene	Homo sapiens	8-11
11455967-16	2001	Several proteins phosphorylated by the activated FLT3 signaling pathway, including STAT 5A, STAT 5B and CBL, were no longer phosphorylated when these cells were treated with AG1296.	6,7-dimethoxy-3-phenylquinoxaline	174-180	Cbl proto-oncogene	Homo sapiens	104-107
11448952-3	2001	The c-Cbl-dependent ubiquitination of Src and c-Cbl requires c-Cbl"s RING finger, Src kinase activity, and c-Cbl"s tyrosine phosphorylation, probably on Tyr-371.	Tyrosine	115-123	Cbl proto-oncogene	Homo sapiens	4-9
11448952-3	2001	The c-Cbl-dependent ubiquitination of Src and c-Cbl requires c-Cbl"s RING finger, Src kinase activity, and c-Cbl"s tyrosine phosphorylation, probably on Tyr-371.	Tyrosine	115-123	Cbl proto-oncogene	Homo sapiens	46-51
11448952-3	2001	The c-Cbl-dependent ubiquitination of Src and c-Cbl requires c-Cbl"s RING finger, Src kinase activity, and c-Cbl"s tyrosine phosphorylation, probably on Tyr-371.	Tyrosine	115-123	Cbl proto-oncogene	Homo sapiens	46-51
11448952-3	2001	The c-Cbl-dependent ubiquitination of Src and c-Cbl requires c-Cbl"s RING finger, Src kinase activity, and c-Cbl"s tyrosine phosphorylation, probably on Tyr-371.	Tyrosine	115-123	Cbl proto-oncogene	Homo sapiens	46-51
11448952-3	2001	The c-Cbl-dependent ubiquitination of Src and c-Cbl requires c-Cbl"s RING finger, Src kinase activity, and c-Cbl"s tyrosine phosphorylation, probably on Tyr-371.	Tyrosine	153-156	Cbl proto-oncogene	Homo sapiens	4-9
11448952-3	2001	The c-Cbl-dependent ubiquitination of Src and c-Cbl requires c-Cbl"s RING finger, Src kinase activity, and c-Cbl"s tyrosine phosphorylation, probably on Tyr-371.	Tyrosine	153-156	Cbl proto-oncogene	Homo sapiens	46-51
11448952-3	2001	The c-Cbl-dependent ubiquitination of Src and c-Cbl requires c-Cbl"s RING finger, Src kinase activity, and c-Cbl"s tyrosine phosphorylation, probably on Tyr-371.	Tyrosine	153-156	Cbl proto-oncogene	Homo sapiens	46-51
11448952-3	2001	The c-Cbl-dependent ubiquitination of Src and c-Cbl requires c-Cbl"s RING finger, Src kinase activity, and c-Cbl"s tyrosine phosphorylation, probably on Tyr-371.	Tyrosine	153-156	Cbl proto-oncogene	Homo sapiens	46-51
11494134-1	2001	The Cbl proto-oncogene product is tyrosine phosphorylated in response to a wide variety of stimuli.	Tyrosine	34-42	Cbl proto-oncogene	Homo sapiens	4-7
11494134-6	2001	The major proline-rich region of Cbl was required for its phosphorylation by c-Abl, but not by a constitutively activated Abl mutant, suggesting Cbl activates c-Abl by engaging its SH3 domain.	Proline	10-17	Cbl proto-oncogene	Homo sapiens	33-36
11494134-6	2001	The major proline-rich region of Cbl was required for its phosphorylation by c-Abl, but not by a constitutively activated Abl mutant, suggesting Cbl activates c-Abl by engaging its SH3 domain.	Proline	10-17	Cbl proto-oncogene	Homo sapiens	145-148
11494134-7	2001	Efficient phosphorylation of Cbl and its stable association with Abl required the SH2 domain of Abl, suggesting that SH2-phosphotyrosine interactions prevent dissociation of active Abl from Cbl.	Phosphotyrosine	121-136	Cbl proto-oncogene	Homo sapiens	29-32
11494134-7	2001	Efficient phosphorylation of Cbl and its stable association with Abl required the SH2 domain of Abl, suggesting that SH2-phosphotyrosine interactions prevent dissociation of active Abl from Cbl.	Phosphotyrosine	121-136	Cbl proto-oncogene	Homo sapiens	190-193
11494134-9	2001	Studies with Nck mutants suggested that the Nck SH2 domain is responsible for inhibiting the activity of Abl toward both Cbl and Nck itself, most likely by competing with the Abl SH2 for tyrosine-phosphorylated binding sites.	Tyrosine	187-195	Cbl proto-oncogene	Homo sapiens	121-124
11262396-5	2001	Using glutathione S-transferase fusion proteins, we observed that the Src homology 2 domain of Vav2 binds tyrosine-phosphorylated proteins from TCR-stimulated Jurkat T cell lysates, including c-Cbl and SLP-76.	Glutathione	6-17	Cbl proto-oncogene	Homo sapiens	192-197
11262396-5	2001	Using glutathione S-transferase fusion proteins, we observed that the Src homology 2 domain of Vav2 binds tyrosine-phosphorylated proteins from TCR-stimulated Jurkat T cell lysates, including c-Cbl and SLP-76.	Tyrosine	106-114	Cbl proto-oncogene	Homo sapiens	192-197
11375680-1	2001	Glutathionylcobalamin (gamma-glutamylcysteinylglycinylcobalamin; gamma-GluCysGly-Cbl) is a natural product which functions as an intermediate in the biosynthesis of the active B(12) coenzymes adenosylcobalamin and methylcobalamin.	glutathionylcobalamin	0-21	Cbl proto-oncogene	Homo sapiens	81-84
11375680-1	2001	Glutathionylcobalamin (gamma-glutamylcysteinylglycinylcobalamin; gamma-GluCysGly-Cbl) is a natural product which functions as an intermediate in the biosynthesis of the active B(12) coenzymes adenosylcobalamin and methylcobalamin.	gamma-glutamylcysteinylglycinylcobalamin	23-63	Cbl proto-oncogene	Homo sapiens	81-84
11375680-1	2001	Glutathionylcobalamin (gamma-glutamylcysteinylglycinylcobalamin; gamma-GluCysGly-Cbl) is a natural product which functions as an intermediate in the biosynthesis of the active B(12) coenzymes adenosylcobalamin and methylcobalamin.	cobamamide	192-209	Cbl proto-oncogene	Homo sapiens	81-84
11375680-1	2001	Glutathionylcobalamin (gamma-glutamylcysteinylglycinylcobalamin; gamma-GluCysGly-Cbl) is a natural product which functions as an intermediate in the biosynthesis of the active B(12) coenzymes adenosylcobalamin and methylcobalamin.	mecobalamin	214-229	Cbl proto-oncogene	Homo sapiens	81-84
11375680-2	2001	Of interest to the present studies is glutathionylcobalamin"s unique stability in comparison to other thiolatocobalamins, notably the &gt; or =6 x 10(4) fold less stable cysteinylcobalamin, Cys-Cbl.	glutathionylcobalamin	38-59	Cbl proto-oncogene	Homo sapiens	194-197
11375680-4	2001	As with glutathionylCbl, the dipeptide gamma-GluCys-Cbl forms a stable thiolatocobalamin.	Dipeptides	29-38	Cbl proto-oncogene	Homo sapiens	20-23
11375680-4	2001	As with glutathionylCbl, the dipeptide gamma-GluCys-Cbl forms a stable thiolatocobalamin.	thiolatocobalamin	71-88	Cbl proto-oncogene	Homo sapiens	20-23
11375680-7	2001	To probe any ground-state structural basis for the possible stabilization in gamma-GluCys-containing cobalamins, gamma-GluCys-Cbl was crystallized and yielded the first X-ray structural determination of a true thiolatocobalamin, and only the second structure of a cobalamin containing a Co-S bond, the first example being Randaccio and co-workers" 1999 structure of the thioketone complex, thioureacobalamin, (NH(2))(2)CSCbl.	gamma-glutamylcysteine	113-125	Cbl proto-oncogene	Homo sapiens	126-129
11375680-7	2001	To probe any ground-state structural basis for the possible stabilization in gamma-GluCys-containing cobalamins, gamma-GluCys-Cbl was crystallized and yielded the first X-ray structural determination of a true thiolatocobalamin, and only the second structure of a cobalamin containing a Co-S bond, the first example being Randaccio and co-workers" 1999 structure of the thioketone complex, thioureacobalamin, (NH(2))(2)CSCbl.	thiolatocobalamin	210-227	Cbl proto-oncogene	Homo sapiens	126-129
11493652-3	2001	Cbl molecules constitute a novel type of E3 or ubiquitin ligase family that is recruited to phosphotyrosine motifs.	Phosphotyrosine	92-107	Cbl proto-oncogene	Homo sapiens	0-3
11309621-7	2001	Here we show that phosphorylated Cbl recruits the CrkII-C3G complex to lipid rafts, where C3G specifically activates the small GTP-binding protein TC10.	Guanosine Triphosphate	127-130	Cbl proto-oncogene	Homo sapiens	33-36
11263968-0	2001	L-selectin tyrosine phosphorylates cbl and induces association of tyrosine-phosphorylated cbl with crkl and grb2.	Tyrosine	11-19	Cbl proto-oncogene	Homo sapiens	35-38
11263968-0	2001	L-selectin tyrosine phosphorylates cbl and induces association of tyrosine-phosphorylated cbl with crkl and grb2.	Tyrosine	11-19	Cbl proto-oncogene	Homo sapiens	90-93
11263968-0	2001	L-selectin tyrosine phosphorylates cbl and induces association of tyrosine-phosphorylated cbl with crkl and grb2.	Tyrosine	66-74	Cbl proto-oncogene	Homo sapiens	90-93
11263968-6	2001	There is an activation induced association of tyrosine phosphorylated Cbl with Grb2 and CrkL, respectively, but not CrkII.	Tyrosine	46-54	Cbl proto-oncogene	Homo sapiens	70-73
11222622-7	2001	These results indicate blockade of the c-Cbl/CAP pathway directly inhibits insulin-stimulated glucose uptake, which results in secondary inhibition of glycogen synthase activation and glycogen synthesis.	Glucose	94-101	Cbl proto-oncogene	Homo sapiens	39-44
11222622-7	2001	These results indicate blockade of the c-Cbl/CAP pathway directly inhibits insulin-stimulated glucose uptake, which results in secondary inhibition of glycogen synthase activation and glycogen synthesis.	Glycogen	151-159	Cbl proto-oncogene	Homo sapiens	39-44
11260061-1	2001	In this study, we show that the adapter proteins CrkL and Cbl undergo increases in tyrosine phosphorylation and form an intracellular complex in platelets stimulated with the snake venom toxin convulxin, a selective agonist at the collagen receptor glycoprotein VI (GPVI).	Tyrosine	83-91	Cbl proto-oncogene	Homo sapiens	58-61
11067845-0	2001	The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction.	Tyrosine	88-96	Cbl proto-oncogene	Homo sapiens	72-77
11067845-4	2001	The second SH3 domain of CMS bound specifically to a tyrosine-phosphorylated protein of 120 kDa, which we identified as the proto-oncoprotein c-Cbl.	Tyrosine	53-61	Cbl proto-oncogene	Homo sapiens	142-147
11067845-5	2001	The c-Cbl-binding site for CMS mapped to the carboxyl terminus of c-Cbl and is different from the proline-rich region known to bind SH3-containing proteins.	Proline	98-105	Cbl proto-oncogene	Homo sapiens	4-9
11067845-6	2001	CMS binding to c-Cbl was markedly attenuated in a tyrosine phosphorylation-defective c-Cbl mutant indicating that this interaction is dependent on the tyrosine phosphorylation of CMS.	Tyrosine	50-58	Cbl proto-oncogene	Homo sapiens	15-20
11067845-6	2001	CMS binding to c-Cbl was markedly attenuated in a tyrosine phosphorylation-defective c-Cbl mutant indicating that this interaction is dependent on the tyrosine phosphorylation of CMS.	Tyrosine	50-58	Cbl proto-oncogene	Homo sapiens	85-90
11067845-6	2001	CMS binding to c-Cbl was markedly attenuated in a tyrosine phosphorylation-defective c-Cbl mutant indicating that this interaction is dependent on the tyrosine phosphorylation of CMS.	Tyrosine	151-159	Cbl proto-oncogene	Homo sapiens	15-20
11067845-6	2001	CMS binding to c-Cbl was markedly attenuated in a tyrosine phosphorylation-defective c-Cbl mutant indicating that this interaction is dependent on the tyrosine phosphorylation of CMS.	Tyrosine	151-159	Cbl proto-oncogene	Homo sapiens	85-90
11024037-6	2001	CD43 signals induced a Cbl serine phosphorylation-dependent interaction with the tau-isoform of 14-3-3. protein.	Serine	27-33	Cbl proto-oncogene	Homo sapiens	23-26
11157475-9	2001	Enhanced activation of fyn and lyn kinases and the tyrosine phosphorylation of cbl were also observed.	Tyrosine	51-59	Cbl proto-oncogene	Homo sapiens	79-82
11330837-1	2001	The carboxyterminal domain of the epidermal growth factor receptor (EGFR)--a putative binding site for the ubiquitin ligase Cbl--is the site of serine phosphorylation events which are essential for ligand-dependent EGFR desensitization and degradation.	Serine	144-150	Cbl proto-oncogene	Homo sapiens	124-127
11024037-7	2001	Protein kinase C-mediated Cbl serine phosphorylation was required for this interaction, because the PKC inhibitor RO-31-8220 prevented it, as well as 14-3-3 dimerization.	Serine	30-36	Cbl proto-oncogene	Homo sapiens	26-29
11024037-7	2001	Protein kinase C-mediated Cbl serine phosphorylation was required for this interaction, because the PKC inhibitor RO-31-8220 prevented it, as well as 14-3-3 dimerization.	Ro 31-8220	114-124	Cbl proto-oncogene	Homo sapiens	26-29
11024037-8	2001	Moreover, mutation of Cbl serine residues 619, 623, 639, and 642 abolished the interaction between Cbl and 14-3-3.	Serine	26-32	Cbl proto-oncogene	Homo sapiens	22-25
11024037-8	2001	Moreover, mutation of Cbl serine residues 619, 623, 639, and 642 abolished the interaction between Cbl and 14-3-3.	Serine	26-32	Cbl proto-oncogene	Homo sapiens	99-113
11149930-4	2001	Furthermore, the PTB domain of Cbl is shown to bind to phosphorylated Tyr-416 in the activation loop of Src, the autophosphorylation site of Src, inhibiting Src kinase activity and integrin-mediated adhesion.	Tyrosine	70-73	Cbl proto-oncogene	Homo sapiens	31-34
11684816-7	2001	The Papp for [125I]-avidin/biotin and [125I]- avidin/biotinyl-Cbl were respectively increased by 2-fold, compared to that for [125I]-avidin and 4-fold, compared to that for [125I]-beta-lactoglobulin and [54Co]-Cbl/IF.	LY 165163	4-8	Cbl proto-oncogene	Homo sapiens	62-65
11024037-10	2001	However, under normal conditions, PKC activation resulting from CD43 engagement was required to activate the MAPK pathway, suggesting that phosphorylation of Cbl on serine residues by PKC and its association with 14-3-3 molecules may play a role in preventing the Cbl inhibitory effect on the Ras-MAPK pathway.	Serine	165-171	Cbl proto-oncogene	Homo sapiens	158-161
11024037-11	2001	These data suggest that by inducing its phosphorylation on serine residues, CD43-mediated signals may regulate the molecular associations and functions of the Cbl adapter protein.	Serine	59-65	Cbl proto-oncogene	Homo sapiens	159-162
11684816-7	2001	The Papp for [125I]-avidin/biotin and [125I]- avidin/biotinyl-Cbl were respectively increased by 2-fold, compared to that for [125I]-avidin and 4-fold, compared to that for [125I]-beta-lactoglobulin and [54Co]-Cbl/IF.	LY 165163	4-8	Cbl proto-oncogene	Homo sapiens	210-213
11684816-7	2001	The Papp for [125I]-avidin/biotin and [125I]- avidin/biotinyl-Cbl were respectively increased by 2-fold, compared to that for [125I]-avidin and 4-fold, compared to that for [125I]-beta-lactoglobulin and [54Co]-Cbl/IF.	Biotin	27-33	Cbl proto-oncogene	Homo sapiens	210-213
11684816-10	2001	Conversely it decreased by 80% the Papp for Cbl/IF, that uses transepithelial pathway.	LY 165163	35-39	Cbl proto-oncogene	Homo sapiens	44-50
11146548-7	2000	In Met transformed cells, Crk predominantly associates with the Cbl and Gab1docking proteins in a tyrosine phosphorylation dependent manner.	Tyrosine	98-106	Cbl proto-oncogene	Homo sapiens	64-67
11133830-2	2001	Engagement of human CD2 by mitogenic pairs of anti-CD2 mAb induces tyrosine phosphorylation of a number of intracellular proteins including a 120 kDa phosphoprotein that we identify as the proto-oncogene c-Cbl.	Tyrosine	67-75	Cbl proto-oncogene	Homo sapiens	189-209
11133830-3	2001	Rapidly tyrosine phosphorylated following stimulation of a number of cell surface receptors, c-Cbl is an adaptor protein that has been shown to associate with a complex of intracellular signaling molecules, and to mediate both positive and negative regulatory effects.	Tyrosine	8-16	Cbl proto-oncogene	Homo sapiens	93-98
11133830-6	2001	The inhibitory effect of c-Cbl depended upon its N-terminal phosphotyrosine-binding domain, the domain that has been shown to be required for inhibition of the Syk/ZAP-70 family kinases.	Phosphotyrosine	60-75	Cbl proto-oncogene	Homo sapiens	25-30
11399323-6	2000	CD2 crosslinking results in the marked tyrosine phosphorylation of Cbl in an antibody concentration- and time-dependent manner.	Tyrosine	39-47	Cbl proto-oncogene	Homo sapiens	67-70
11399323-7	2000	Immunodepletion studies reveal that Grb2-associated tyrosine phosphorylated p120 kDa protein is Cbl.	Tyrosine	52-60	Cbl proto-oncogene	Homo sapiens	96-99
11399323-9	2000	In addition, we demonstrate that CrkL associates with a large portion of tyrosine phosphorylated Cbl after CD2 stimulation of NK3.3 cells.	Tyrosine	73-81	Cbl proto-oncogene	Homo sapiens	97-100
11399323-10	2000	In contrast to constitutive Cbl association with Grb2, tyrosine phosphorylated Cbl interacts with CrkL via its SH2 domain only after CD2 stimulation.	Tyrosine	55-63	Cbl proto-oncogene	Homo sapiens	79-82
11154562-2	2000	Under these conditions rate-determining Co-C heterolytic cleavage is preceded by rapid addition of cyanide to AdoCbl to form an intermediate, (beta-5"-deoxyadenosyl)(alpha-cyano)cobalamin ((beta-Ado)(alpha-CN)Cbl-), identified by 1H NMR spectroscopy.	Cyanides	99-106	Cbl proto-oncogene	Homo sapiens	113-116
11154562-2	2000	Under these conditions rate-determining Co-C heterolytic cleavage is preceded by rapid addition of cyanide to AdoCbl to form an intermediate, (beta-5"-deoxyadenosyl)(alpha-cyano)cobalamin ((beta-Ado)(alpha-CN)Cbl-), identified by 1H NMR spectroscopy.	beta-5"-deoxyadenosyl	143-164	Cbl proto-oncogene	Homo sapiens	113-116
11154562-2	2000	Under these conditions rate-determining Co-C heterolytic cleavage is preceded by rapid addition of cyanide to AdoCbl to form an intermediate, (beta-5"-deoxyadenosyl)(alpha-cyano)cobalamin ((beta-Ado)(alpha-CN)Cbl-), identified by 1H NMR spectroscopy.	-cyano)	171-178	Cbl proto-oncogene	Homo sapiens	113-116
11154562-2	2000	Under these conditions rate-determining Co-C heterolytic cleavage is preceded by rapid addition of cyanide to AdoCbl to form an intermediate, (beta-5"-deoxyadenosyl)(alpha-cyano)cobalamin ((beta-Ado)(alpha-CN)Cbl-), identified by 1H NMR spectroscopy.	beta-ado	190-198	Cbl proto-oncogene	Homo sapiens	113-116
11154562-2	2000	Under these conditions rate-determining Co-C heterolytic cleavage is preceded by rapid addition of cyanide to AdoCbl to form an intermediate, (beta-5"-deoxyadenosyl)(alpha-cyano)cobalamin ((beta-Ado)(alpha-CN)Cbl-), identified by 1H NMR spectroscopy.	Hydrogen	230-232	Cbl proto-oncogene	Homo sapiens	113-116
11154562-6	2000	Increasing the percentage of D2O in the DMF/D2O solvent mixture also increases the reaction rate, and for D2O &gt; or = 50% there is a change in the rate-determining step, with formation of the (beta-Ado)(alpha-CN)Cbl- intermediate becoming rate-determining.	Deuterium Oxide	29-32	Cbl proto-oncogene	Homo sapiens	214-217
11154562-6	2000	Increasing the percentage of D2O in the DMF/D2O solvent mixture also increases the reaction rate, and for D2O &gt; or = 50% there is a change in the rate-determining step, with formation of the (beta-Ado)(alpha-CN)Cbl- intermediate becoming rate-determining.	Dimethylformamide	40-43	Cbl proto-oncogene	Homo sapiens	214-217
11154562-6	2000	Increasing the percentage of D2O in the DMF/D2O solvent mixture also increases the reaction rate, and for D2O &gt; or = 50% there is a change in the rate-determining step, with formation of the (beta-Ado)(alpha-CN)Cbl- intermediate becoming rate-determining.	Deuterium Oxide	44-47	Cbl proto-oncogene	Homo sapiens	214-217
11154562-6	2000	Increasing the percentage of D2O in the DMF/D2O solvent mixture also increases the reaction rate, and for D2O &gt; or = 50% there is a change in the rate-determining step, with formation of the (beta-Ado)(alpha-CN)Cbl- intermediate becoming rate-determining.	Deuterium Oxide	44-47	Cbl proto-oncogene	Homo sapiens	214-217
11154562-7	2000	A mechanism in 92% DMF/8% D2O is proposed which involves rapid reversible formation of (beta-Ado)(alpha-CN)Cbl- from base-off AdoCbl plus cyanide, followed by rate-determining solvent-assisted cleavage of the Co-C bond of the intermediate and subsequent rapid addition of a second cyanide to give the products.	Dimethylformamide	19-22	Cbl proto-oncogene	Homo sapiens	107-110
11154562-7	2000	A mechanism in 92% DMF/8% D2O is proposed which involves rapid reversible formation of (beta-Ado)(alpha-CN)Cbl- from base-off AdoCbl plus cyanide, followed by rate-determining solvent-assisted cleavage of the Co-C bond of the intermediate and subsequent rapid addition of a second cyanide to give the products.	Deuterium Oxide	26-29	Cbl proto-oncogene	Homo sapiens	107-110
11154562-7	2000	A mechanism in 92% DMF/8% D2O is proposed which involves rapid reversible formation of (beta-Ado)(alpha-CN)Cbl- from base-off AdoCbl plus cyanide, followed by rate-determining solvent-assisted cleavage of the Co-C bond of the intermediate and subsequent rapid addition of a second cyanide to give the products.	(beta-ado)	87-97	Cbl proto-oncogene	Homo sapiens	107-110
11746915-3	2001	A method for analysis of DNA-phosphate adducts was developed earlier utilizing the supernucleophilicity of cob(I)alamin to transfer alkyl groups from the phosphotriester configuration in DNA, with the formation of a Co-substituted alkyl-cobalamin (alkyl-Cbl) complex.	Phosphates	29-38	Cbl proto-oncogene	Homo sapiens	254-257
11746915-3	2001	A method for analysis of DNA-phosphate adducts was developed earlier utilizing the supernucleophilicity of cob(I)alamin to transfer alkyl groups from the phosphotriester configuration in DNA, with the formation of a Co-substituted alkyl-cobalamin (alkyl-Cbl) complex.	Vitamin B 12	107-119	Cbl proto-oncogene	Homo sapiens	254-257
11746915-3	2001	A method for analysis of DNA-phosphate adducts was developed earlier utilizing the supernucleophilicity of cob(I)alamin to transfer alkyl groups from the phosphotriester configuration in DNA, with the formation of a Co-substituted alkyl-cobalamin (alkyl-Cbl) complex.	co-substituted alkyl-cobalamin	216-246	Cbl proto-oncogene	Homo sapiens	254-257
11746915-9	2001	Limits of quantitation for 2-hydroxypropyl-cobalamin (OHPr-Cbl) were 0.2 and 2 pg/microL (or 0.1 and 1 fmol/microL) using selected ion recording (SIR) with eluent I and II, respectively.	2-hydroxypropyl-cobalamin	27-52	Cbl proto-oncogene	Homo sapiens	59-62
11237251-3	2001	The models of this process show that in both methylcobalamin (CH3Cbl) and AdoCbl, compression of the axial Co-N bond does engender upward folding of the corrin ring, and that the extent of such upward folding is smaller in an analog in which the normal 5,6-dimethylbenzimidazole axial ligand is replaced by the sterically smaller ligand, imidazole (CH3(lm)Cbl and Ado(lm)Cbl).	mecobalamin	45-60	Cbl proto-oncogene	Homo sapiens	65-68
11237251-3	2001	The models of this process show that in both methylcobalamin (CH3Cbl) and AdoCbl, compression of the axial Co-N bond does engender upward folding of the corrin ring, and that the extent of such upward folding is smaller in an analog in which the normal 5,6-dimethylbenzimidazole axial ligand is replaced by the sterically smaller ligand, imidazole (CH3(lm)Cbl and Ado(lm)Cbl).	co-n	107-111	Cbl proto-oncogene	Homo sapiens	65-68
11237251-3	2001	The models of this process show that in both methylcobalamin (CH3Cbl) and AdoCbl, compression of the axial Co-N bond does engender upward folding of the corrin ring, and that the extent of such upward folding is smaller in an analog in which the normal 5,6-dimethylbenzimidazole axial ligand is replaced by the sterically smaller ligand, imidazole (CH3(lm)Cbl and Ado(lm)Cbl).	co-n	107-111	Cbl proto-oncogene	Homo sapiens	77-80
11237251-3	2001	The models of this process show that in both methylcobalamin (CH3Cbl) and AdoCbl, compression of the axial Co-N bond does engender upward folding of the corrin ring, and that the extent of such upward folding is smaller in an analog in which the normal 5,6-dimethylbenzimidazole axial ligand is replaced by the sterically smaller ligand, imidazole (CH3(lm)Cbl and Ado(lm)Cbl).	corrin	153-159	Cbl proto-oncogene	Homo sapiens	65-68
11237251-3	2001	The models of this process show that in both methylcobalamin (CH3Cbl) and AdoCbl, compression of the axial Co-N bond does engender upward folding of the corrin ring, and that the extent of such upward folding is smaller in an analog in which the normal 5,6-dimethylbenzimidazole axial ligand is replaced by the sterically smaller ligand, imidazole (CH3(lm)Cbl and Ado(lm)Cbl).	corrin	153-159	Cbl proto-oncogene	Homo sapiens	77-80
11237251-3	2001	The models of this process show that in both methylcobalamin (CH3Cbl) and AdoCbl, compression of the axial Co-N bond does engender upward folding of the corrin ring, and that the extent of such upward folding is smaller in an analog in which the normal 5,6-dimethylbenzimidazole axial ligand is replaced by the sterically smaller ligand, imidazole (CH3(lm)Cbl and Ado(lm)Cbl).	5,6-dimethylbenzimidazole	253-278	Cbl proto-oncogene	Homo sapiens	77-80
11237251-4	2001	Furthermore, in AdoCbl, this upward folding of the corrin is accompanied by increases in the carbon-cobalt bond length and in the Co-C-C bond angle (which are also less pronounced in Ado(Im)Cbl), and which indicate that the Co-C bond is indeed destabilized by this mechanism.	corrin	51-57	Cbl proto-oncogene	Homo sapiens	19-22
11237251-4	2001	Furthermore, in AdoCbl, this upward folding of the corrin is accompanied by increases in the carbon-cobalt bond length and in the Co-C-C bond angle (which are also less pronounced in Ado(Im)Cbl), and which indicate that the Co-C bond is indeed destabilized by this mechanism.	Carbon	93-99	Cbl proto-oncogene	Homo sapiens	19-22
11237251-4	2001	Furthermore, in AdoCbl, this upward folding of the corrin is accompanied by increases in the carbon-cobalt bond length and in the Co-C-C bond angle (which are also less pronounced in Ado(Im)Cbl), and which indicate that the Co-C bond is indeed destabilized by this mechanism.	Cobalt	100-106	Cbl proto-oncogene	Homo sapiens	19-22
11237251-4	2001	Furthermore, in AdoCbl, this upward folding of the corrin is accompanied by increases in the carbon-cobalt bond length and in the Co-C-C bond angle (which are also less pronounced in Ado(Im)Cbl), and which indicate that the Co-C bond is indeed destabilized by this mechanism.	Carbon	130-131	Cbl proto-oncogene	Homo sapiens	19-22
11237251-4	2001	Furthermore, in AdoCbl, this upward folding of the corrin is accompanied by increases in the carbon-cobalt bond length and in the Co-C-C bond angle (which are also less pronounced in Ado(Im)Cbl), and which indicate that the Co-C bond is indeed destabilized by this mechanism.	Carbon	130-131	Cbl proto-oncogene	Homo sapiens	19-22
11237251-9	2001	Stretching the Co-C bond to simulate the approach to the transition state was found to result in an upward folding of the corrin ring, a slight decrease in the axial Co-N bond length, a slight displacement of the metal atom from the plane of the equatorial nitrogens towards the "lower" axial ligand, and a decrease in strain energy amounting to about 8 kcal mol(-1) for both AdoCbl and Ado(Im)Cbl.	Cobalt	15-17	Cbl proto-oncogene	Homo sapiens	379-382
11237251-9	2001	Stretching the Co-C bond to simulate the approach to the transition state was found to result in an upward folding of the corrin ring, a slight decrease in the axial Co-N bond length, a slight displacement of the metal atom from the plane of the equatorial nitrogens towards the "lower" axial ligand, and a decrease in strain energy amounting to about 8 kcal mol(-1) for both AdoCbl and Ado(Im)Cbl.	Carbon	15-16	Cbl proto-oncogene	Homo sapiens	379-382
11237251-10	2001	In such modeled transition states, compression of the axial Co-N bond to just below 2.0 A (the distance subsequently found to provide maximal stabilization of the transition state by increased orbital overlap) required about 4 kcal mol(-1) for AdoCbl, and about 2.5 kcal mol(-1) for Ado(Im)Cbl.	co-n	60-64	Cbl proto-oncogene	Homo sapiens	247-250
11237251-11	2001	ZINDO/1 calculations on slightly simplified structures showed that maximal electronic stabilization of the transition state by about 10 kcal mol(-1) occurred at an axial Co-N bond distance of 1.96 A for both AdoCbl and Ado(Im)Cbl.	co-n	170-174	Cbl proto-oncogene	Homo sapiens	211-214
10940298-5	2000	The negative effect of c-Cbl is antagonized by v-Cbl, a virus-encoded oncogenic truncated form of c-Cbl.	v-cbl	47-52	Cbl proto-oncogene	Homo sapiens	23-28
10940298-5	2000	The negative effect of c-Cbl is antagonized by v-Cbl, a virus-encoded oncogenic truncated form of c-Cbl.	v-cbl	47-52	Cbl proto-oncogene	Homo sapiens	98-103
11042121-0	2000	Platelet alpha IIb-beta 3 integrin engagement induces the tyrosine phosphorylation of Cbl and its association with phosphoinositide 3-kinase and Syk.	Tyrosine	58-66	Cbl proto-oncogene	Homo sapiens	86-89
11042121-4	2000	During thrombin-induced platelet activation, Cbl was tyrosine phosphorylated, and phosphoinositide 3-kinase (PI 3-kinase) activity measured in Cbl immunoprecipitates was increased.	Tyrosine	53-61	Cbl proto-oncogene	Homo sapiens	45-48
11042121-9	2000	The results show that, following integrin alpha IIb-beta 3 engagement, Cbl is tyrosine phosphorylated, recruits PI 3-kinase to this integrin signalling pathway and possibly enhances PI 3-kinase activity, downstream of Src-family tyrosine kinases and Syk activation.	Tyrosine	78-86	Cbl proto-oncogene	Homo sapiens	71-74
11010818-6	2000	However, the EGFR substrates Shc and c-Cbl were as efficiently tyrosine phosphorylated in endocytosis-deficient HeLa cells exhibiting only low-affinity EGFRs as in HeLa cells with intact endocytosis and with both high- and low-affinity EGFRs.	Tyrosine	63-71	Cbl proto-oncogene	Homo sapiens	37-42
11154562-7	2000	A mechanism in 92% DMF/8% D2O is proposed which involves rapid reversible formation of (beta-Ado)(alpha-CN)Cbl- from base-off AdoCbl plus cyanide, followed by rate-determining solvent-assisted cleavage of the Co-C bond of the intermediate and subsequent rapid addition of a second cyanide to give the products.	-cn	103-106	Cbl proto-oncogene	Homo sapiens	107-110
11154562-7	2000	A mechanism in 92% DMF/8% D2O is proposed which involves rapid reversible formation of (beta-Ado)(alpha-CN)Cbl- from base-off AdoCbl plus cyanide, followed by rate-determining solvent-assisted cleavage of the Co-C bond of the intermediate and subsequent rapid addition of a second cyanide to give the products.	Cyanides	138-145	Cbl proto-oncogene	Homo sapiens	107-110
11154562-7	2000	A mechanism in 92% DMF/8% D2O is proposed which involves rapid reversible formation of (beta-Ado)(alpha-CN)Cbl- from base-off AdoCbl plus cyanide, followed by rate-determining solvent-assisted cleavage of the Co-C bond of the intermediate and subsequent rapid addition of a second cyanide to give the products.	Cyanides	281-288	Cbl proto-oncogene	Homo sapiens	107-110
11001060-9	2000	Thus, localization of the Cbl-CAP complex to lipid rafts generates a pathway that is crucial in the regulation of glucose uptake.	Glucose	114-121	Cbl proto-oncogene	Homo sapiens	26-29
10891544-0	2000	C-Cbl protein in human cancer tissues is frequently tyrosine phosphorylated in a tumor-specific manner.	Tyrosine	52-60	Cbl proto-oncogene	Homo sapiens	0-5
10833515-7	2000	Further, stimulation of untransformed cells with H(2)O(2) or pervanadate increased tyrosine phosphorylation of each of the most prominent known substrates of BCR/ABL, including c-ABL, c-CBL, SHC, and SHP-2.	Hydrogen Peroxide	49-57	Cbl proto-oncogene	Homo sapiens	184-189
10833515-7	2000	Further, stimulation of untransformed cells with H(2)O(2) or pervanadate increased tyrosine phosphorylation of each of the most prominent known substrates of BCR/ABL, including c-ABL, c-CBL, SHC, and SHP-2.	pervanadate	61-72	Cbl proto-oncogene	Homo sapiens	184-189
10833515-7	2000	Further, stimulation of untransformed cells with H(2)O(2) or pervanadate increased tyrosine phosphorylation of each of the most prominent known substrates of BCR/ABL, including c-ABL, c-CBL, SHC, and SHP-2.	Tyrosine	83-91	Cbl proto-oncogene	Homo sapiens	184-189
10962563-4	2000	We report here that c-Cbl, which is a Gab1-like docking protein, also becomes tyrosine-phosphorylated in response to Met activation and serves as a docking molecule for various SH2-containing molecules, including Crk.	Tyrosine	78-86	Cbl proto-oncogene	Homo sapiens	20-25
10891544-1	2000	To search for the signaling pathway relevant to the tumorigenesis in human, we examined the expression and tyrosine phosphorylation of c-cbl proto-oncogene product, c-Cbl, in various human cancer cell lines and surgical specimens.	Tyrosine	107-115	Cbl proto-oncogene	Homo sapiens	135-140
10891544-1	2000	To search for the signaling pathway relevant to the tumorigenesis in human, we examined the expression and tyrosine phosphorylation of c-cbl proto-oncogene product, c-Cbl, in various human cancer cell lines and surgical specimens.	Tyrosine	107-115	Cbl proto-oncogene	Homo sapiens	165-170
10891544-2	2000	In cells derived from human cancer, we found constitutive tyrosine phosphorylation of c-Cbl protein, whereas its phosphorylation was undetectable in control ECV304 cells.	Tyrosine	58-66	Cbl proto-oncogene	Homo sapiens	86-91
10891544-3	2000	Expression and tyrosine phosphorylation of c-Cbl was also examined in various surgical specimens.	Tyrosine	15-23	Cbl proto-oncogene	Homo sapiens	43-48
10891544-5	2000	We found tyrosine phosphorylation of c-Cbl protein in 12 cases (33%) of these tumor tissues in a tumor-specific manner.	Tyrosine	9-17	Cbl proto-oncogene	Homo sapiens	37-42
10947074-0	2000	Beta2 integrin (CD11/CD18)-mediated signaling involves tyrosine phosphorylation of c-Cbl in human neutrophils.	Tyrosine	55-63	Cbl proto-oncogene	Homo sapiens	83-88
10898581-10	2000	From the biotin-dye conjugates studied, biotin-CN-Cbl, 6b, was selected as the best conjugate for the HPLC assay.	Biotin	9-15	Cbl proto-oncogene	Homo sapiens	50-53
10887099-1	2000	Megaloblastic anemia 1 (MGA1) is an autosomal recessive disorder caused by the selective intestinal malabsorption of intrinsic factor (IF) and vitamin B(12)/cobalamin (Cbl) in complex.	Niacinamide	143-152	Cbl proto-oncogene	Homo sapiens	168-171
10887099-1	2000	Megaloblastic anemia 1 (MGA1) is an autosomal recessive disorder caused by the selective intestinal malabsorption of intrinsic factor (IF) and vitamin B(12)/cobalamin (Cbl) in complex.	Vitamin B 12	157-166	Cbl proto-oncogene	Homo sapiens	168-171
10887099-5	2000	In agreement with the binding data, the wild-type protein, but not the FM1 mutant protein, potently inhibits 37 degrees C uptake of iodine 125-IF-Cbl in cubilin-expressing epithelial cells.	Iodine	132-138	Cbl proto-oncogene	Homo sapiens	146-149
10898580-6	2000	Two biotin-CN-Cbl conjugates, one containing unaltered biotin and the other containing iminobiotin, were prepared as reference compounds for comparison purposes.	Biotin	4-10	Cbl proto-oncogene	Homo sapiens	14-17
10898581-13	2000	The biotin-sarcosine-CN-Cbl conjugate was expected to have a more rapid dissociation rate than the other biotin-dye conjugates.	Biotin	4-10	Cbl proto-oncogene	Homo sapiens	24-27
10898580-8	2000	The rate of dissociation of the biotin-CN-Cbl derivative from Av and SAv was significantly increased for biotin derivatives containing those structural features.	Biotin	32-38	Cbl proto-oncogene	Homo sapiens	42-45
10898581-13	2000	The biotin-sarcosine-CN-Cbl conjugate was expected to have a more rapid dissociation rate than the other biotin-dye conjugates.	Sarcosine	11-20	Cbl proto-oncogene	Homo sapiens	24-27
10898580-8	2000	The rate of dissociation of the biotin-CN-Cbl derivative from Av and SAv was significantly increased for biotin derivatives containing those structural features.	Biotin	105-111	Cbl proto-oncogene	Homo sapiens	42-45
10898581-13	2000	The biotin-sarcosine-CN-Cbl conjugate was expected to have a more rapid dissociation rate than the other biotin-dye conjugates.	Biotin	105-111	Cbl proto-oncogene	Homo sapiens	24-27
10898581-17	2000	The results obtained indicate that CN-Cbl conjugates of biotin derivatives can be used to determine relative on-rates and off-rates of biotin derivatives with Av and SAv.	Biotin	56-62	Cbl proto-oncogene	Homo sapiens	38-41
10898581-17	2000	The results obtained indicate that CN-Cbl conjugates of biotin derivatives can be used to determine relative on-rates and off-rates of biotin derivatives with Av and SAv.	Biotin	135-141	Cbl proto-oncogene	Homo sapiens	38-41
10898581-18	2000	The studies also demonstrated that the biotin-CN-Cbl conjugate, 6b, can be used as a reference compound to compare on-rates and off-rates of nonchromophoric biotin derivatives.	Biotin	39-45	Cbl proto-oncogene	Homo sapiens	49-52
10907644-9	2000	The RA-dependent interaction of CrkL with CBL was mediated by binding of the SH2 domain of CrkL to tyrosine phosphorylated CBL, suggesting that CBL provides a docking site for engagement of CrkL in a RA-activated cellular pathway.	Tretinoin	200-202	Cbl proto-oncogene	Homo sapiens	123-126
10910043-4	2000	This process necessitates recruitment of the c-Cbl ubiquitin ligase to tyrosine 1112 of ErbB-2.	Tyrosine	71-79	Cbl proto-oncogene	Homo sapiens	45-50
10907644-5	2000	MATERIALS AND METHODS: The effects of RA treatment on CBL and CrkL phosphorylation, as well as on protein-protein interactions, were determined in studies involving immunoprecipitations of cell extracts with specific antibodies and Western blots.	Tretinoin	38-40	Cbl proto-oncogene	Homo sapiens	54-57
10907644-7	2000	RESULTS: Treatment of NB-4 or HL-60 cells with RA resulted in strong tyrosine phosphorylation of CBL, which was time and dose dependent.	Tretinoin	47-49	Cbl proto-oncogene	Homo sapiens	97-100
10907644-7	2000	RESULTS: Treatment of NB-4 or HL-60 cells with RA resulted in strong tyrosine phosphorylation of CBL, which was time and dose dependent.	Tyrosine	69-77	Cbl proto-oncogene	Homo sapiens	97-100
10907644-8	2000	Similarly, RA induced tyrosine phosphorylation of the CrkL adapter and the association of CrkL with CBL.	Tretinoin	11-13	Cbl proto-oncogene	Homo sapiens	100-103
10907644-9	2000	The RA-dependent interaction of CrkL with CBL was mediated by binding of the SH2 domain of CrkL to tyrosine phosphorylated CBL, suggesting that CBL provides a docking site for engagement of CrkL in a RA-activated cellular pathway.	Tretinoin	4-6	Cbl proto-oncogene	Homo sapiens	42-45
10907644-9	2000	The RA-dependent interaction of CrkL with CBL was mediated by binding of the SH2 domain of CrkL to tyrosine phosphorylated CBL, suggesting that CBL provides a docking site for engagement of CrkL in a RA-activated cellular pathway.	Tretinoin	4-6	Cbl proto-oncogene	Homo sapiens	123-126
10907644-9	2000	The RA-dependent interaction of CrkL with CBL was mediated by binding of the SH2 domain of CrkL to tyrosine phosphorylated CBL, suggesting that CBL provides a docking site for engagement of CrkL in a RA-activated cellular pathway.	Tretinoin	4-6	Cbl proto-oncogene	Homo sapiens	123-126
10907644-9	2000	The RA-dependent interaction of CrkL with CBL was mediated by binding of the SH2 domain of CrkL to tyrosine phosphorylated CBL, suggesting that CBL provides a docking site for engagement of CrkL in a RA-activated cellular pathway.	Tretinoin	200-202	Cbl proto-oncogene	Homo sapiens	123-126
10907644-9	2000	The RA-dependent interaction of CrkL with CBL was mediated by binding of the SH2 domain of CrkL to tyrosine phosphorylated CBL, suggesting that CBL provides a docking site for engagement of CrkL in a RA-activated cellular pathway.	Tyrosine	99-107	Cbl proto-oncogene	Homo sapiens	42-45
10907644-9	2000	The RA-dependent interaction of CrkL with CBL was mediated by binding of the SH2 domain of CrkL to tyrosine phosphorylated CBL, suggesting that CBL provides a docking site for engagement of CrkL in a RA-activated cellular pathway.	Tyrosine	99-107	Cbl proto-oncogene	Homo sapiens	123-126
10907644-9	2000	The RA-dependent interaction of CrkL with CBL was mediated by binding of the SH2 domain of CrkL to tyrosine phosphorylated CBL, suggesting that CBL provides a docking site for engagement of CrkL in a RA-activated cellular pathway.	Tyrosine	99-107	Cbl proto-oncogene	Homo sapiens	123-126
10907644-11	2000	CONCLUSIONS: These findings demonstrate that the CBL-CrkL pathway is one of the mediators of the effects of RA on APL cells and suggest that one of the mechanisms of synergy between RA and interferons may involve regulation of components of this signaling cascade.	Tretinoin	108-110	Cbl proto-oncogene	Homo sapiens	49-52
10907644-9	2000	The RA-dependent interaction of CrkL with CBL was mediated by binding of the SH2 domain of CrkL to tyrosine phosphorylated CBL, suggesting that CBL provides a docking site for engagement of CrkL in a RA-activated cellular pathway.	Tretinoin	200-202	Cbl proto-oncogene	Homo sapiens	42-45
10907644-11	2000	CONCLUSIONS: These findings demonstrate that the CBL-CrkL pathway is one of the mediators of the effects of RA on APL cells and suggest that one of the mechanisms of synergy between RA and interferons may involve regulation of components of this signaling cascade.	Tretinoin	182-184	Cbl proto-oncogene	Homo sapiens	49-52
10829062-2	2000	Here we report that the kinase-deficient Src (SrcKD) directly inhibits the tyrosine phosphorylation of Cbl and other cellular proteins by Abl.	Tyrosine	75-83	Cbl proto-oncogene	Homo sapiens	103-106
10867505-3	2000	Recently, we found that engagement of beta(2) integrin using two different approaches, such as cell adhesion induced by IL-5 or direct ligation of alpha(M)beta(2), triggered tyrosine phosphorylation of Cbl, the product of the c-cbl proto-oncogene, paxillin, a cytoskeletal protein, an unidentified 115-kD protein, and subsequent cellular degranulation.	Tyrosine	174-182	Cbl proto-oncogene	Homo sapiens	202-205
10867505-5	2000	Tyrosine phosphorylation of Cbl, paxillin, and a 115-kD protein may play important roles in adhesion-dependent cellular functions of eosinophils.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	28-31
10657627-3	2000	During treatment of NB-4 human cells with IFN-gamma, c-cbl protooncogene product is rapidly phosphorylated on tyrosine and provides a docking site for the src homology 2 domain of CrkL, which also undergoes IFN-gamma-dependent tyrosine phosphorylation.	Tyrosine	110-118	Cbl proto-oncogene	Homo sapiens	53-58
10734046-1	2000	c-Cbl-associating protein (CAP) is a multifunctional signaling protein that interacts with c-Cbl, facilitating the tyrosine phosphorylation of c-Cbl in response to insulin.	Tyrosine	115-123	Cbl proto-oncogene	Homo sapiens	0-5
10734046-1	2000	c-Cbl-associating protein (CAP) is a multifunctional signaling protein that interacts with c-Cbl, facilitating the tyrosine phosphorylation of c-Cbl in response to insulin.	Tyrosine	115-123	Cbl proto-oncogene	Homo sapiens	91-96
10734046-1	2000	c-Cbl-associating protein (CAP) is a multifunctional signaling protein that interacts with c-Cbl, facilitating the tyrosine phosphorylation of c-Cbl in response to insulin.	Tyrosine	115-123	Cbl proto-oncogene	Homo sapiens	91-96
10734046-2	2000	In 3T3-L1 adipocytes and diabetic rodents, CAP gene expression is stimulated by activators of peroxisome proliferator activator receptor gamma (PPARgamma), such as thiazolidinediones (TZDs), resulting in increased insulin-stimulated c-Cbl phosphorylation.	Thiazolidinediones	164-182	Cbl proto-oncogene	Homo sapiens	233-238
10734046-2	2000	In 3T3-L1 adipocytes and diabetic rodents, CAP gene expression is stimulated by activators of peroxisome proliferator activator receptor gamma (PPARgamma), such as thiazolidinediones (TZDs), resulting in increased insulin-stimulated c-Cbl phosphorylation.	Thiazolidinediones	184-188	Cbl proto-oncogene	Homo sapiens	233-238
10766803-2	2000	Binding of aquo-, cyano-, or azidocobalamin (Cbl.OH(2), Cbl.CN, and Cbl.N(3), respectively) to the recombinant human transcobalamin (TC) and haptocorrin from human plasma was investigated via stopped-flow spectroscopy.	aquo-, cyano-, or azidocobalamin	11-43	Cbl proto-oncogene	Homo sapiens	45-48
10766803-2	2000	Binding of aquo-, cyano-, or azidocobalamin (Cbl.OH(2), Cbl.CN, and Cbl.N(3), respectively) to the recombinant human transcobalamin (TC) and haptocorrin from human plasma was investigated via stopped-flow spectroscopy.	aquo-, cyano-, or azidocobalamin	11-43	Cbl proto-oncogene	Homo sapiens	56-59
10766803-2	2000	Binding of aquo-, cyano-, or azidocobalamin (Cbl.OH(2), Cbl.CN, and Cbl.N(3), respectively) to the recombinant human transcobalamin (TC) and haptocorrin from human plasma was investigated via stopped-flow spectroscopy.	aquo-, cyano-, or azidocobalamin	11-43	Cbl proto-oncogene	Homo sapiens	56-59
10766803-2	2000	Binding of aquo-, cyano-, or azidocobalamin (Cbl.OH(2), Cbl.CN, and Cbl.N(3), respectively) to the recombinant human transcobalamin (TC) and haptocorrin from human plasma was investigated via stopped-flow spectroscopy.	Water	49-54	Cbl proto-oncogene	Homo sapiens	45-48
10766803-5	2000	The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water.	Water	23-28	Cbl proto-oncogene	Homo sapiens	19-22
10766803-5	2000	The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water.	Water	23-28	Cbl proto-oncogene	Homo sapiens	111-114
10766803-5	2000	The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water.	Water	23-28	Cbl proto-oncogene	Homo sapiens	111-114
10766803-5	2000	The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water.	Water	115-120	Cbl proto-oncogene	Homo sapiens	19-22
10766803-5	2000	The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water.	Water	115-120	Cbl proto-oncogene	Homo sapiens	111-114
10766803-5	2000	The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water.	Water	115-120	Cbl proto-oncogene	Homo sapiens	111-114
10766803-5	2000	The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water.	Water	173-178	Cbl proto-oncogene	Homo sapiens	19-22
10766803-5	2000	The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water.	Water	173-178	Cbl proto-oncogene	Homo sapiens	111-114
10766803-5	2000	The second step of Cbl.OH(2) binding was interpreted as a transformation of the initial "open" intermediate TC.Cbl.OH(2) to the "closed" conformation TC(Cbl) with displaced water.	Water	173-178	Cbl proto-oncogene	Homo sapiens	111-114
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Water	141-146	Cbl proto-oncogene	Homo sapiens	153-156
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Water	141-146	Cbl proto-oncogene	Homo sapiens	213-216
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Water	141-146	Cbl proto-oncogene	Homo sapiens	213-216
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Water	157-162	Cbl proto-oncogene	Homo sapiens	153-156
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Water	157-162	Cbl proto-oncogene	Homo sapiens	213-216
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Water	157-162	Cbl proto-oncogene	Homo sapiens	213-216
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Cyanides	167-174	Cbl proto-oncogene	Homo sapiens	153-156
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Cyanides	167-174	Cbl proto-oncogene	Homo sapiens	213-216
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Cyanides	167-174	Cbl proto-oncogene	Homo sapiens	213-216
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Azides	178-183	Cbl proto-oncogene	Homo sapiens	153-156
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Azides	178-183	Cbl proto-oncogene	Homo sapiens	213-216
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Azides	178-183	Cbl proto-oncogene	Homo sapiens	213-216
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Water	232-237	Cbl proto-oncogene	Homo sapiens	153-156
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Water	232-237	Cbl proto-oncogene	Homo sapiens	213-216
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Water	232-237	Cbl proto-oncogene	Homo sapiens	213-216
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Nitrogen	241-242	Cbl proto-oncogene	Homo sapiens	153-156
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Nitrogen	241-242	Cbl proto-oncogene	Homo sapiens	213-216
10766803-6	2000	The backward transition from the closed to the open conformation was the reason for the identical rate-limiting steps during substitution of H(2)O in TC.Cbl.OH(2) for cyanide or azide according to the reaction TC(Cbl) --&gt; TC.Cbl.OH(2) + CN(-)/N(3)(-).	Nitrogen	241-242	Cbl proto-oncogene	Homo sapiens	213-216
10766803-8	2000	Different conformations of holo-TC, determined by the nature of the active group in the bound Cbl, may direct transportation of cobalamins in the organism.	holo-tc	27-34	Cbl proto-oncogene	Homo sapiens	94-97
10766803-8	2000	Different conformations of holo-TC, determined by the nature of the active group in the bound Cbl, may direct transportation of cobalamins in the organism.	Vitamin B 12	128-138	Cbl proto-oncogene	Homo sapiens	94-97
10706632-5	2000	Indeed, CD38 ligation on monocytes induces tyrosine phosphorylation of several intracellular proteins including the protooncogene product c-cbl and the fgr and hck tyrosine kinases.	Tyrosine	43-51	Cbl proto-oncogene	Homo sapiens	138-143
10679202-1	2000	The c-Cbl protooncogene product is a prominent substrate of protein tyrosine kinases and is rapidly tyrosine-phosphorylated upon stimulation of a wide variety of cell-surface receptors.	Tyrosine	68-76	Cbl proto-oncogene	Homo sapiens	4-9
10679202-6	2000	The CIN85-c-Cbl association was enhanced shortly after stimulation of 293 cells with epidermal growth factor (EGF) and gradually diminished to a basal level, which correlated with a tyrosine phosphorylation level of c-Cbl.	Tyrosine	182-190	Cbl proto-oncogene	Homo sapiens	10-15
10679202-6	2000	The CIN85-c-Cbl association was enhanced shortly after stimulation of 293 cells with epidermal growth factor (EGF) and gradually diminished to a basal level, which correlated with a tyrosine phosphorylation level of c-Cbl.	Tyrosine	182-190	Cbl proto-oncogene	Homo sapiens	216-221
10657627-3	2000	During treatment of NB-4 human cells with IFN-gamma, c-cbl protooncogene product is rapidly phosphorylated on tyrosine and provides a docking site for the src homology 2 domain of CrkL, which also undergoes IFN-gamma-dependent tyrosine phosphorylation.	Tyrosine	227-235	Cbl proto-oncogene	Homo sapiens	53-58
10648820-1	2000	Tyrosine phosphorylation of Cbl and its association with signal-transducing molecules in response to macrophage colony-stimulating factor (M-CSF) were analyzed by using cell lines which express the wild-type and a mutant M-CSF receptor, Fms.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	28-31
10648820-4	2000	These results suggest that phosphorylation of tyrosine 723 is particularly important for the recruitment of Cbl to the M-CSF receptor, but is not required for the phosphorylation and binding of Cbl to signal-transducing molecules such as p85.	Tyrosine	46-54	Cbl proto-oncogene	Homo sapiens	108-111
10623852-3	2000	After a 2-min incubation with 10-6 M calyculin, a transient tyrosine phosphorylation of a subset of proteins, among which Cbl and Syk, was observed.	Tyrosine	60-68	Cbl proto-oncogene	Homo sapiens	122-125
10620516-4	2000	Stimulation of alpha4beta1 integrins on HL60 cells also leads to increased tyrosine phosphorylation of the 120 kDa adaptor protein Cbl.	Tyrosine	75-83	Cbl proto-oncogene	Homo sapiens	131-134
10623852-5	2000	Tyrosine phosphorylation of Cbl in response to CD32 cross-linking was inhibited by calyculin, and this inhibition was linked with a slower electrophoretic mobility of Cbl as a consequence of its phosphorylation on serine/threonine residues.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	28-31
10623852-5	2000	Tyrosine phosphorylation of Cbl in response to CD32 cross-linking was inhibited by calyculin, and this inhibition was linked with a slower electrophoretic mobility of Cbl as a consequence of its phosphorylation on serine/threonine residues.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	167-170
10623852-5	2000	Tyrosine phosphorylation of Cbl in response to CD32 cross-linking was inhibited by calyculin, and this inhibition was linked with a slower electrophoretic mobility of Cbl as a consequence of its phosphorylation on serine/threonine residues.	Serine	214-220	Cbl proto-oncogene	Homo sapiens	28-31
10623852-5	2000	Tyrosine phosphorylation of Cbl in response to CD32 cross-linking was inhibited by calyculin, and this inhibition was linked with a slower electrophoretic mobility of Cbl as a consequence of its phosphorylation on serine/threonine residues.	Serine	214-220	Cbl proto-oncogene	Homo sapiens	167-170
10623852-5	2000	Tyrosine phosphorylation of Cbl in response to CD32 cross-linking was inhibited by calyculin, and this inhibition was linked with a slower electrophoretic mobility of Cbl as a consequence of its phosphorylation on serine/threonine residues.	Threonine	221-230	Cbl proto-oncogene	Homo sapiens	28-31
10623852-5	2000	Tyrosine phosphorylation of Cbl in response to CD32 cross-linking was inhibited by calyculin, and this inhibition was linked with a slower electrophoretic mobility of Cbl as a consequence of its phosphorylation on serine/threonine residues.	Threonine	221-230	Cbl proto-oncogene	Homo sapiens	167-170
10644984-8	2000	G-CSF induced the tyrosine phosphorylation of Cbl and increased activity of PI 3-kinase in wild-type and syk-deficient, but non in lyn-deficient, cells.	Tyrosine	18-26	Cbl proto-oncogene	Homo sapiens	46-49
10570290-6	1999	Cross-linking of FcgammaRI induces the tyrosine phosphorylation of Cbl, which forms a complex with Grb2 and Shc via the Cbl C terminus.	Tyrosine	39-47	Cbl proto-oncogene	Homo sapiens	67-70
10617633-7	2000	Point mutations of conserved cysteine residues or a histidine in the RING finger domain, which are required for zinc binding, abrogated the ability of Cbl to negatively regulate Syk in COS-7 cells and Ramos B lymphocytic cells.	Cysteine	29-37	Cbl proto-oncogene	Homo sapiens	151-154
10617633-7	2000	Point mutations of conserved cysteine residues or a histidine in the RING finger domain, which are required for zinc binding, abrogated the ability of Cbl to negatively regulate Syk in COS-7 cells and Ramos B lymphocytic cells.	Histidine	52-61	Cbl proto-oncogene	Homo sapiens	151-154
10617633-7	2000	Point mutations of conserved cysteine residues or a histidine in the RING finger domain, which are required for zinc binding, abrogated the ability of Cbl to negatively regulate Syk in COS-7 cells and Ramos B lymphocytic cells.	carbonyl sulfide	185-188	Cbl proto-oncogene	Homo sapiens	151-154
10570290-6	1999	Cross-linking of FcgammaRI induces the tyrosine phosphorylation of Cbl, which forms a complex with Grb2 and Shc via the Cbl C terminus.	Tyrosine	39-47	Cbl proto-oncogene	Homo sapiens	120-123
10635327-0	1999	Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.	Tyrosine	30-38	Cbl proto-oncogene	Homo sapiens	106-111
10635327-4	1999	This is followed by tyrosine phosphorylation of c-Cbl at a site flanking its RING finger, which enables receptor ubiquitination and degradation.	Tyrosine	20-28	Cbl proto-oncogene	Homo sapiens	48-53
10635328-5	1999	TRAF6, in turn, enhances the kinase activity of c-Src leading to tyrosine phosphorylation of downstream signaling molecules such as c-Cbl.	Tyrosine	65-73	Cbl proto-oncogene	Homo sapiens	134-137
10514377-4	1999	The c-Cbl protein acted as an E3 that can recognize tyrosine-phosphorylated substrates, such as the activated platelet-derived growth factor receptor, through its SH2 domain and that recruits and allosterically activates an E2 ubiquitin-conjugating enzyme through its RING domain.	Tyrosine	52-60	Cbl proto-oncogene	Homo sapiens	4-9
10551821-7	1999	Whereas CD19 does not appear to be involved in this SYK-dependent pathway, the SYK substrate CBL is likely involved as the dominant negative SYK markedly attenuates CBL tyrosine phosphorylation and completely blocks the BCR-dependent association of CBL with p85 PI3K.	Tyrosine	169-177	Cbl proto-oncogene	Homo sapiens	93-96
10551821-7	1999	Whereas CD19 does not appear to be involved in this SYK-dependent pathway, the SYK substrate CBL is likely involved as the dominant negative SYK markedly attenuates CBL tyrosine phosphorylation and completely blocks the BCR-dependent association of CBL with p85 PI3K.	Tyrosine	169-177	Cbl proto-oncogene	Homo sapiens	165-168
10551821-7	1999	Whereas CD19 does not appear to be involved in this SYK-dependent pathway, the SYK substrate CBL is likely involved as the dominant negative SYK markedly attenuates CBL tyrosine phosphorylation and completely blocks the BCR-dependent association of CBL with p85 PI3K.	Tyrosine	169-177	Cbl proto-oncogene	Homo sapiens	165-168
10531381-7	1999	MG132, a proteasome inhibitor, significantly prolonged the ligand-induced phosphorylation of both the EGFR and c-Cbl.	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	0-5	Cbl proto-oncogene	Homo sapiens	111-116
10521482-1	1999	A role in c-Cbl"s tyrosine phosphorylation and its association with epidermal growth factor receptor.	Tyrosine	18-26	Cbl proto-oncogene	Homo sapiens	10-15
10521482-3	1999	Several structural features of c-Cbl, including the phosphotyrosine-binding domain, proline-rich domain, and motifs containing phosphotyrosine and phosphoserine residues, mediate the association of c-Cbl with other components of these complexes.	Phosphotyrosine	52-67	Cbl proto-oncogene	Homo sapiens	31-36
10521482-3	1999	Several structural features of c-Cbl, including the phosphotyrosine-binding domain, proline-rich domain, and motifs containing phosphotyrosine and phosphoserine residues, mediate the association of c-Cbl with other components of these complexes.	Phosphotyrosine	52-67	Cbl proto-oncogene	Homo sapiens	198-203
10521482-3	1999	Several structural features of c-Cbl, including the phosphotyrosine-binding domain, proline-rich domain, and motifs containing phosphotyrosine and phosphoserine residues, mediate the association of c-Cbl with other components of these complexes.	Proline	84-91	Cbl proto-oncogene	Homo sapiens	31-36
10521482-3	1999	Several structural features of c-Cbl, including the phosphotyrosine-binding domain, proline-rich domain, and motifs containing phosphotyrosine and phosphoserine residues, mediate the association of c-Cbl with other components of these complexes.	Proline	84-91	Cbl proto-oncogene	Homo sapiens	198-203
10521482-3	1999	Several structural features of c-Cbl, including the phosphotyrosine-binding domain, proline-rich domain, and motifs containing phosphotyrosine and phosphoserine residues, mediate the association of c-Cbl with other components of these complexes.	Phosphotyrosine	127-142	Cbl proto-oncogene	Homo sapiens	31-36
10521482-3	1999	Several structural features of c-Cbl, including the phosphotyrosine-binding domain, proline-rich domain, and motifs containing phosphotyrosine and phosphoserine residues, mediate the association of c-Cbl with other components of these complexes.	Phosphotyrosine	127-142	Cbl proto-oncogene	Homo sapiens	198-203
10521482-3	1999	Several structural features of c-Cbl, including the phosphotyrosine-binding domain, proline-rich domain, and motifs containing phosphotyrosine and phosphoserine residues, mediate the association of c-Cbl with other components of these complexes.	Phosphoserine	147-160	Cbl proto-oncogene	Homo sapiens	31-36
10521482-3	1999	Several structural features of c-Cbl, including the phosphotyrosine-binding domain, proline-rich domain, and motifs containing phosphotyrosine and phosphoserine residues, mediate the association of c-Cbl with other components of these complexes.	Phosphoserine	147-160	Cbl proto-oncogene	Homo sapiens	198-203
10521482-8	1999	In cells, the deletion of the leucine zipper caused a decrease in both the tyrosine phosphorylation of Cbl and its association with the epidermal growth factor receptor following stimulation with epidermal growth factor, thus demonstrating a role for the leucine zipper in c-Cbl"s signaling functions.	Tyrosine	75-83	Cbl proto-oncogene	Homo sapiens	103-106
10595738-7	1999	The Cbl oncogene product was also tyrosine-phosphorylated in U87MG glioma cells upon EGF stimulation.	Tyrosine	34-42	Cbl proto-oncogene	Homo sapiens	4-7
10490623-8	1999	Cells expressing AP1510-induced ErbB1 homodimers were able to associate with and induce phosphorylation of c-Cbl.	AP 1510	17-23	Cbl proto-oncogene	Homo sapiens	107-112
10490604-0	1999	The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells.	Phosphotyrosine	42-57	Cbl proto-oncogene	Homo sapiens	18-21
10490604-1	1999	T-cell receptor (TCR) engagement results in the activation of Src family (Lck and Fyn) and ZAP-70 protein tyrosine kinases, leading to tyrosine phosphorylation of multiple cellular substrates including the complex adapter protein c-Cbl.	Tyrosine	106-114	Cbl proto-oncogene	Homo sapiens	230-235
10490604-0	1999	The oncogenic 70Z Cbl mutation blocks the phosphotyrosine binding domain-dependent negative regulation of ZAP-70 by c-Cbl in Jurkat T cells.	Phosphotyrosine	42-57	Cbl proto-oncogene	Homo sapiens	116-121
10490623-10	1999	Using rapamycin-inducible heterodimerization we show that c-Cbl is unable to associate with ErbB1 in a ErbB1-ErbB2 heterodimer most likely because ErbB2 is unable to phosphorylate the c-Cbl binding site on ErbB1.	Sirolimus	6-15	Cbl proto-oncogene	Homo sapiens	58-63
10490604-2	1999	Moreover, Cbl is tyrosine phosphorylated upon engagement of growth factor receptors, cytokine receptors, and immunoreceptors and functions as a negative regulator of tyrosine kinase signalling pathways.	Tyrosine	17-25	Cbl proto-oncogene	Homo sapiens	10-13
10490604-3	1999	Cbl associates via its phosphotyrosine binding (PTB) domain to the ZAP-70 pY292 negative regulatory phosphotyrosine.	Phosphotyrosine	23-38	Cbl proto-oncogene	Homo sapiens	0-3
10502361-1	1999	This report describes an investigation aimed at preparation of radioiodinated cyanocobalamin (CN-Cbl) monomers and dimers with improved water solubility and decreased nonspecific binding.	Vitamin B 12	78-92	Cbl proto-oncogene	Homo sapiens	97-100
10490604-3	1999	Cbl associates via its phosphotyrosine binding (PTB) domain to the ZAP-70 pY292 negative regulatory phosphotyrosine.	Phosphotyrosine	100-115	Cbl proto-oncogene	Homo sapiens	0-3
10502361-1	1999	This report describes an investigation aimed at preparation of radioiodinated cyanocobalamin (CN-Cbl) monomers and dimers with improved water solubility and decreased nonspecific binding.	Water	136-141	Cbl proto-oncogene	Homo sapiens	97-100
10502361-3	1999	The initial step in the synthesis of the CN-Cbl derivatives was mild acid hydrolysis of CN-Cbl, 1, followed by separation of the resultant corrin ring b-, d-, and e-monocarboxylate isomers.	corrin	139-145	Cbl proto-oncogene	Homo sapiens	44-47
10502361-3	1999	The initial step in the synthesis of the CN-Cbl derivatives was mild acid hydrolysis of CN-Cbl, 1, followed by separation of the resultant corrin ring b-, d-, and e-monocarboxylate isomers.	e-monocarboxylate	163-180	Cbl proto-oncogene	Homo sapiens	44-47
10502361-6	1999	The synthesis of a monomeric CN-Cbl derivative, 6a, which can be used for radioiodination, was accomplished by reaction of 4 with p-tri-n-butylstannylbenzoate tetrafluorophenyl (TFP) ester, 5a.	p-tri-n-butylstannylbenzoate tetrafluorophenyl (	130-178	Cbl proto-oncogene	Homo sapiens	32-35
10502361-6	1999	The synthesis of a monomeric CN-Cbl derivative, 6a, which can be used for radioiodination, was accomplished by reaction of 4 with p-tri-n-butylstannylbenzoate tetrafluorophenyl (TFP) ester, 5a.	tfp) ester	178-188	Cbl proto-oncogene	Homo sapiens	32-35
10502361-7	1999	Two CN-Cbl dimers containing the arylstannane radioiodination moiety were also synthesized.	arylstannane	33-45	Cbl proto-oncogene	Homo sapiens	7-10
10449770-4	1999	N-terminal Cbl interacts with SLAP in vivo and in vitro in a tyrosine phosphorylation-independent manner.	Tyrosine	61-69	Cbl proto-oncogene	Homo sapiens	11-14
10400642-5	1999	Activation of protein kinase C by phorbol ester also causes rapid (t(1)/(2) = 2 min) dissociation of both CrkL and p85/phosphoinositide 3-kinase from Cbl concomitant with Cbl tyrosine dephosphorylation.	Phorbol Esters	34-47	Cbl proto-oncogene	Homo sapiens	150-153
10428778-2	1999	c-Cbl, a tyrosine phosphorylation substrate shared by several signaling pathways, accelerates desensitization by recruiting EGFR and increasing receptor polyubiquitination.	Tyrosine	9-17	Cbl proto-oncogene	Homo sapiens	0-5
10428778-4	1999	Mutagenesis of a single cysteine residue impaired the ability of c-Cbl to enhance both down-regulation and ubiquitination of EGFR in living cells, although the mutant retained binding to the activated receptor.	Cysteine	24-32	Cbl proto-oncogene	Homo sapiens	65-70
10477741-7	1999	The complex adapter proteins, Cbl and SLP-76, are physically associated in myeloid cells and both proteins undergo tyrosine phosphorylation upon FcalphaR stimulation.	Tyrosine	115-123	Cbl proto-oncogene	Homo sapiens	30-33
10477741-8	1999	These data indicate that the stimulation of FcalphaR results in the modulation of adaptor complexes containing tyrosine-phosphorylated Cbl, Shc, SHIP, Grb2, and Crkl.	Tyrosine	111-119	Cbl proto-oncogene	Homo sapiens	135-138
10400642-5	1999	Activation of protein kinase C by phorbol ester also causes rapid (t(1)/(2) = 2 min) dissociation of both CrkL and p85/phosphoinositide 3-kinase from Cbl concomitant with Cbl tyrosine dephosphorylation.	Phorbol Esters	34-47	Cbl proto-oncogene	Homo sapiens	171-174
10400642-7	1999	Furthermore, the rate of attenuation of both Cbl tyrosine phosphorylation and its association with CrkL following stimulation with anti-CD3/CD4 antibodies is much slower in Jurkat cells treated with GF109203X.	Tyrosine	49-57	Cbl proto-oncogene	Homo sapiens	45-48
10358153-0	1999	Protein kinase C activation inhibits tyrosine phosphorylation of Cbl and its recruitment of Src homology 2 domain-containing proteins.	Tyrosine	37-45	Cbl proto-oncogene	Homo sapiens	65-68
10391678-0	1999	Tyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblasts.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	28-33
10391678-1	1999	The protooncogenic protein c-Cbl becomes tyrosine phosphorylated in normal cells in response to a variety of external stimuli, as well as in cells transformed by oncogenic protein tyrosine kinases.	Tyrosine	41-49	Cbl proto-oncogene	Homo sapiens	27-32
10391678-2	1999	Tyrosine phosphorylation of c-Cbl upregulates its binding to multiple crucial signaling molecules.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	28-33
10391678-5	1999	In this system, wild-type c-Cbl facilitated adhesion and spreading of v-Abl-transformed fibroblasts on the extracellular matrix, while reducing anchorage independence of these cells, as measured by their colony-forming efficiency in soft agar.	Agar	238-242	Cbl proto-oncogene	Homo sapiens	26-31
10358153-1	1999	One of the major proteins that is rapidly tyrosine phosphorylated upon stimulation of the TCR/CD3 complex is the 120-kDa product of the c-cbl protooncogene (Cbl).	Tyrosine	42-50	Cbl proto-oncogene	Homo sapiens	136-141
10358153-1	1999	One of the major proteins that is rapidly tyrosine phosphorylated upon stimulation of the TCR/CD3 complex is the 120-kDa product of the c-cbl protooncogene (Cbl).	Tyrosine	42-50	Cbl proto-oncogene	Homo sapiens	157-160
10358153-6	1999	Furthermore, a serine-rich motif at the C terminus of Cbl, which is critical for PMA-induced 14-3-3 binding, is also phosphorylated by PKCalpha and PKCtheta in vitro.	Serine	15-21	Cbl proto-oncogene	Homo sapiens	54-57
10358153-7	1999	These results suggest that, by regulating tyrosine and serine phosphorylation of Cbl, PKC is able to control the association of Cbl with signaling intermediates, such as SH2 domain-containing proteins and 14-3-3 proteins, which may consequently result in the modulation of its function.	Tyrosine	42-50	Cbl proto-oncogene	Homo sapiens	128-131
10358153-7	1999	These results suggest that, by regulating tyrosine and serine phosphorylation of Cbl, PKC is able to control the association of Cbl with signaling intermediates, such as SH2 domain-containing proteins and 14-3-3 proteins, which may consequently result in the modulation of its function.	Serine	55-61	Cbl proto-oncogene	Homo sapiens	81-84
10358153-7	1999	These results suggest that, by regulating tyrosine and serine phosphorylation of Cbl, PKC is able to control the association of Cbl with signaling intermediates, such as SH2 domain-containing proteins and 14-3-3 proteins, which may consequently result in the modulation of its function.	Serine	55-61	Cbl proto-oncogene	Homo sapiens	128-131
10391678-8	1999	Analysis of the role of individual tyrosine phosphorylation sites of c-Cbl in these phenomena indicates that both phosphatidylinositol-3" kinase and the CrkL adaptor protein may be involved in the observed effects of c-Cbl.	Tyrosine	35-43	Cbl proto-oncogene	Homo sapiens	69-74
10233884-8	1999	Cross-linking of CD43 induced tyrosine phosphorylation of several intracellular molecules including the protein tyrosine kinase Syk, the proto-oncogene product Cbl, and phospholipase C (PLC)-gamma2 in MO7e cells.	Tyrosine	30-38	Cbl proto-oncogene	Homo sapiens	160-163
10391678-9	1999	To summarize, the results presented in this report indicate that c-Cbl is involved in regulation of cell adhesion and cytoskeletal rearrangements, and that these effects of c-Cbl are dependent on its tyrosine phosphorylation.	Tyrosine	200-208	Cbl proto-oncogene	Homo sapiens	65-70
10391678-9	1999	To summarize, the results presented in this report indicate that c-Cbl is involved in regulation of cell adhesion and cytoskeletal rearrangements, and that these effects of c-Cbl are dependent on its tyrosine phosphorylation.	Tyrosine	200-208	Cbl proto-oncogene	Homo sapiens	173-178
10391678-7	1999	By contrast, overexpression of a tyrosine phosphorylation-defective form of c-Cbl increases neither adhesion nor anchorage dependence of v-Abl-transformed fibroblasts.	Tyrosine	33-41	Cbl proto-oncogene	Homo sapiens	76-81
10362357-2	1999	The predicted protein encoded by this gene retains the conserved phosphotyrosine binding domain (PTB) in the N-terminal and the zinc finger but is significantly shorter (MW 52.5 kDa) than the other mammalian cbl proteins.	Phosphotyrosine	65-80	Cbl proto-oncogene	Homo sapiens	208-211
10374881-2	1999	Here, we report that APS was tyrosine phosphorylated by Janus kinase-2 (JAK2) at its C-terminal tyrosine residue and interacted with c-Cbl.	Tyrosine	29-37	Cbl proto-oncogene	Homo sapiens	133-138
10092600-6	1999	Binding of 14-3-3tau to PKCmu is significantly enhanced upon phorbol ester stimulation of PKCmu kinase activity in Jurkat cells and occurs via a Cbl-like serine containing consensus motif.	Serine	154-160	Cbl proto-oncogene	Homo sapiens	145-148
11670948-1	1999	Difluoromethylcobalamin (CF(2)Cbl), a vitamin B(12) analogue with CHF(2) replacing CN, can be synthesized in a two-step procedure from aquocobalamin and CHClF(2).	difluoromethylcobalamin	0-23	Cbl proto-oncogene	Homo sapiens	30-33
11670948-1	1999	Difluoromethylcobalamin (CF(2)Cbl), a vitamin B(12) analogue with CHF(2) replacing CN, can be synthesized in a two-step procedure from aquocobalamin and CHClF(2).	Niacinamide	38-47	Cbl proto-oncogene	Homo sapiens	30-33
11670948-6	1999	The packing motif of CF(2)Cbl is very similar to that described for wet vitamin B(12), a distorted hexagonal close packing of the cobalamin, with channels of water running parallel to the crystallographic c axis through the crystal at x = (1)/(4), y = 0, and x = (3)/(4), y = (1)/(2), respectively.	Niacinamide	72-81	Cbl proto-oncogene	Homo sapiens	26-29
11670948-6	1999	The packing motif of CF(2)Cbl is very similar to that described for wet vitamin B(12), a distorted hexagonal close packing of the cobalamin, with channels of water running parallel to the crystallographic c axis through the crystal at x = (1)/(4), y = 0, and x = (3)/(4), y = (1)/(2), respectively.	Water	158-163	Cbl proto-oncogene	Homo sapiens	26-29
11670948-8	1999	A superposition of the crystal structures of vitamin B(12) and CF(2)Cbl shows a significant change at the molecular level.	Niacinamide	45-54	Cbl proto-oncogene	Homo sapiens	68-71
11670948-9	1999	In CF(2)Cbl, the c side chain of ring B takes on a conformation that brings its terminal amide group near to the CHF(2) group.	Amides	89-94	Cbl proto-oncogene	Homo sapiens	8-11
10092600-6	1999	Binding of 14-3-3tau to PKCmu is significantly enhanced upon phorbol ester stimulation of PKCmu kinase activity in Jurkat cells and occurs via a Cbl-like serine containing consensus motif.	14-3-3tau	11-20	Cbl proto-oncogene	Homo sapiens	145-148
10204582-1	1999	Cbl is a cytosolic protein that is rapidly tyrosine phosphorylated in response to Fc receptor activation and binds to the adaptor proteins Grb2, CrkL, and Nck.	Tyrosine	43-51	Cbl proto-oncogene	Homo sapiens	0-3
10204582-4	1999	Fc gammaRI stimulation in human macrophages was associated with rapid and transient tyrosine phosphorylation of the Cbl adaptor protein.	Tyrosine	84-92	Cbl proto-oncogene	Homo sapiens	116-119
10204582-5	1999	Immunoprecipitated Cbl was complexed with several tyrosine phosphorylated proteins, the most prominent of which was a 38-kDa band identified as the CrkL adaptor protein.	Tyrosine	50-58	Cbl proto-oncogene	Homo sapiens	19-22
10204582-6	1999	CrkL associated with tyrosine-phosphorylated Cbl and itself became tyrosine phosphorylated after Fc gammaRI cross-linking.	Tyrosine	21-29	Cbl proto-oncogene	Homo sapiens	45-48
10204582-6	1999	CrkL associated with tyrosine-phosphorylated Cbl and itself became tyrosine phosphorylated after Fc gammaRI cross-linking.	Tyrosine	67-75	Cbl proto-oncogene	Homo sapiens	45-48
10204582-11	1999	PP1, a specific inhibitor of Src kinases, inhibited the Fc gammaRI-induced respiratory burst, as well as the tyrosine phosphorylation of Cbl and its inducible association with CrkL.	Tyrosine	109-117	Cbl proto-oncogene	Homo sapiens	137-140
10204582-12	1999	These results suggest a fundamental role for the tyrosine phosphorylation of Cbl, CrkL, SLP-76, and Shc and the association of Cbl with CrkL, SLP-76, and Nck in Fc gammaRI signaling in human macrophages.	Tyrosine	49-57	Cbl proto-oncogene	Homo sapiens	77-80
10022120-5	1999	A Tyr-316 Cbl-binding site in Syk was required for the association with and for the maximal tyrosine phosphorylation of Cbl-b.	Tyrosine	92-100	Cbl proto-oncogene	Homo sapiens	10-13
10068674-11	1999	Overexpression of lyp1 reduces Cbl tyrosine phosphorylation, suggesting that it may be a substrate of the phosphatase.	Tyrosine	35-43	Cbl proto-oncogene	Homo sapiens	31-34
10078535-2	1999	The evolutionarily conserved amino-terminal region of Cbl (Cbl-N) binds to phosphorylated tyrosine residues and has cell-transforming activity.	Tyrosine	90-98	Cbl proto-oncogene	Homo sapiens	54-57
10078535-2	1999	The evolutionarily conserved amino-terminal region of Cbl (Cbl-N) binds to phosphorylated tyrosine residues and has cell-transforming activity.	Tyrosine	90-98	Cbl proto-oncogene	Homo sapiens	59-64
10078535-3	1999	Point mutations in Cbl that disrupt its recognition of phosphotyrosine also interfere with its negative regulatory function and, in the case of v-cbl, with its oncogenic potential.	Phosphotyrosine	55-70	Cbl proto-oncogene	Homo sapiens	19-22
10078535-4	1999	In T cells, Cbl-N binds to the tyrosine-phosphorylated inhibitory site of the protein tyrosine kinase ZAP-70.	Tyrosine	31-39	Cbl proto-oncogene	Homo sapiens	12-17
10078535-6	1999	The structures show that Cbl-N is composed of three interacting domains: a four-helix bundle (4H), an EF-hand calcium-binding domain, and a divergent SH2 domain that was not recognizable from the amino-acid sequence of the protein.	4h	94-96	Cbl proto-oncogene	Homo sapiens	25-30
10078535-6	1999	The structures show that Cbl-N is composed of three interacting domains: a four-helix bundle (4H), an EF-hand calcium-binding domain, and a divergent SH2 domain that was not recognizable from the amino-acid sequence of the protein.	Calcium	110-117	Cbl proto-oncogene	Homo sapiens	25-30
9988765-0	1999	Activation of nuclear factor of activated T cells-(NFAT) and activating protein 1 (AP-1) by oncogenic 70Z Cbl requires an intact phosphotyrosine binding domain but not Crk(L) or p85 phosphatidylinositol 3-kinase association.	Phosphotyrosine	129-144	Cbl proto-oncogene	Homo sapiens	106-109
9988765-4	1999	The 70Z Cbl oncoprotein shows increased baseline tyrosine phosphorylation in fibroblasts and enhances nuclear factor of activated T cells (NFAT) activity in Jurkat T cells.	Tyrosine	49-57	Cbl proto-oncogene	Homo sapiens	8-11
9988765-6	1999	We demonstrate that 70Z Cbl shows increased basal and activation-induced tyrosine phosphorylation and association with Crk(L) and p85 PI3K in Jurkat T cells.	Tyrosine	73-81	Cbl proto-oncogene	Homo sapiens	24-27
9988765-8	1999	In contrast, the G306E mutation, which inactivates the phosphotyrosine binding domain of Cbl, blocks NFAT/AP1 activation by 70Z Cbl.	Phosphotyrosine	55-70	Cbl proto-oncogene	Homo sapiens	89-92
9988765-8	1999	In contrast, the G306E mutation, which inactivates the phosphotyrosine binding domain of Cbl, blocks NFAT/AP1 activation by 70Z Cbl.	Phosphotyrosine	55-70	Cbl proto-oncogene	Homo sapiens	128-131
9988765-9	1999	We conclude that 70Z Cbl-induced NFAT/AP1 activation requires the phosphotyrosine binding domain but not Crk(L)/p85 PI3K association.	Phosphotyrosine	66-81	Cbl proto-oncogene	Homo sapiens	21-24
10049786-3	1999	Activation of muscarinic receptors with carbachol was found to inhibit EGF-induced signaling, including tyrosine phosphorylation of the adaptor protein Cbl and of the EGF receptor, and complex formation between Shc proteins and the EGF receptor and Grb2.	Carbachol	40-49	Cbl proto-oncogene	Homo sapiens	152-155
10022120-1	1999	Cbl-b, a mammalian homolog of Cbl, consists of an N-terminal region (Cbl-b-N) highly homologous to oncogenic v-Cbl, a Ring finger, and a C-terminal region containing multiple proline-rich stretches and potential tyrosine phosphorylation sites.	Proline	175-182	Cbl proto-oncogene	Homo sapiens	0-3
10022120-1	1999	Cbl-b, a mammalian homolog of Cbl, consists of an N-terminal region (Cbl-b-N) highly homologous to oncogenic v-Cbl, a Ring finger, and a C-terminal region containing multiple proline-rich stretches and potential tyrosine phosphorylation sites.	Proline	175-182	Cbl proto-oncogene	Homo sapiens	30-33
10022120-1	1999	Cbl-b, a mammalian homolog of Cbl, consists of an N-terminal region (Cbl-b-N) highly homologous to oncogenic v-Cbl, a Ring finger, and a C-terminal region containing multiple proline-rich stretches and potential tyrosine phosphorylation sites.	Tyrosine	212-220	Cbl proto-oncogene	Homo sapiens	0-3
10022120-1	1999	Cbl-b, a mammalian homolog of Cbl, consists of an N-terminal region (Cbl-b-N) highly homologous to oncogenic v-Cbl, a Ring finger, and a C-terminal region containing multiple proline-rich stretches and potential tyrosine phosphorylation sites.	Tyrosine	212-220	Cbl proto-oncogene	Homo sapiens	30-33
10022120-5	1999	A Tyr-316 Cbl-binding site in Syk was required for the association with and for the maximal tyrosine phosphorylation of Cbl-b.	Tyrosine	2-5	Cbl proto-oncogene	Homo sapiens	10-13
9915850-6	1999	Several intracellular signaling proteins, such as CBL and VAV, were phosphorylated on tyrosine in response to CD80, CD86, and anti-CD28 mAb.	Tyrosine	86-94	Cbl proto-oncogene	Homo sapiens	50-53
10348664-7	1999	EGF increased the phosphotyrosine immunoreactivity of 180- and 116-kDa proteins, identified as the EGF receptor and Cbl, respectively.	Phosphotyrosine	18-33	Cbl proto-oncogene	Homo sapiens	116-119
10025673-9	1999	Complexes formed by Sos and Cbl are largely independent and membrane complexes of Cbl with other tyrosine phosphorylated proteins, p85 and Grb2 also contain CSF-1 R. These data raise the possibility that the predicted negative regulatory role of Cbl in macrophages is its enhancement of ligand-induced CSF-1 R internalization/degradation.	Tyrosine	97-105	Cbl proto-oncogene	Homo sapiens	82-85
9890943-2	1999	In this study, we focused on the adaptor protein p120(cbl) (Cbl), which became tyrosine-phosphorylated after platelet activation induced by antibodies.	Tyrosine	79-87	Cbl proto-oncogene	Homo sapiens	49-58
9890943-2	1999	In this study, we focused on the adaptor protein p120(cbl) (Cbl), which became tyrosine-phosphorylated after platelet activation induced by antibodies.	Tyrosine	79-87	Cbl proto-oncogene	Homo sapiens	60-63
9890943-4	1999	An association of Cbl with the p85 subunit of phosphatidylinositol 3-kinase (PI 3-K) occurred in parallel with Cbl tyrosine phosphorylation.	Tyrosine	115-123	Cbl proto-oncogene	Homo sapiens	18-21
9890943-4	1999	An association of Cbl with the p85 subunit of phosphatidylinositol 3-kinase (PI 3-K) occurred in parallel with Cbl tyrosine phosphorylation.	Tyrosine	115-123	Cbl proto-oncogene	Homo sapiens	111-114
9890943-5	1999	We showed by in vitro experiments that Cbl/p85 association was mediated by the Src homology 3 domain of p85/PI 3-K and the proline-rich region of Cbl.	Proline	123-130	Cbl proto-oncogene	Homo sapiens	39-42
9890943-5	1999	We showed by in vitro experiments that Cbl/p85 association was mediated by the Src homology 3 domain of p85/PI 3-K and the proline-rich region of Cbl.	Proline	123-130	Cbl proto-oncogene	Homo sapiens	146-149
9927483-2	1999	Inheritance of an expanded p(CCG)n trinucleotide repeat at the folate-sensitive fragile site FRA11B has been implicated in the generation of the chromosome breakpoint in several Jacobsen syndrome patients.	trinucleotide	35-48	Cbl proto-oncogene	Homo sapiens	93-99
9915850-9	1999	Thus, ligation of CD28 with either CD80 or CD86 leads to shared early signal transduction events such as the tyrosine phosphorylation of CBL and VAV, to NFAT-mediated transcriptional activation, and to the costimulation of interleukin-2 and granulocyte-macrophage colony-stimulating factor production.	Tyrosine	109-117	Cbl proto-oncogene	Homo sapiens	137-140
9989826-7	1999	In vitro and in vivo binding experiments indicate that the tyrosine phosphorylated C-terminal region of APS bound to c-Cbl, which has been shown to be a negative regulator of tyrosine kinases.	Tyrosine	59-67	Cbl proto-oncogene	Homo sapiens	117-122
10449919-5	1999	Fluorescence in situ hybridization studies on the first patient placed the two breakpoints near the folate-sensitive fragile sites FRA11A and FRA11B.	Folic Acid	100-106	Cbl proto-oncogene	Homo sapiens	142-148
16180173-10	1999	In a clinical trial, ABX-CBL was administered to ten patients with acute steroid-resistant GvHD.	Steroids	73-80	Cbl proto-oncogene	Homo sapiens	25-28
10025673-0	1999	CSF-1 stimulated multiubiquitination of the CSF-1 receptor and of Cbl follows their tyrosine phosphorylation and association with other signaling proteins.	Tyrosine	84-92	Cbl proto-oncogene	Homo sapiens	66-69
10025673-1	1999	Addition of colony stimulating factor-1 (CSF-1) to macrophages stimulates the rapid, transient tyrosine phosphorylation, membrane association and multiubiquitination of Cbl (Wang et al.	Tyrosine	95-103	Cbl proto-oncogene	Homo sapiens	169-172
10025673-9	1999	Complexes formed by Sos and Cbl are largely independent and membrane complexes of Cbl with other tyrosine phosphorylated proteins, p85 and Grb2 also contain CSF-1 R. These data raise the possibility that the predicted negative regulatory role of Cbl in macrophages is its enhancement of ligand-induced CSF-1 R internalization/degradation.	Tyrosine	97-105	Cbl proto-oncogene	Homo sapiens	82-85
9851874-5	1998	FcgammaRII crosslinking induced the phosphorylation of Cbl and Nck on tyrosine.	Tyrosine	70-78	Cbl proto-oncogene	Homo sapiens	55-58
9851874-9	1998	A specific Src inhibitor, PP1, was shown to completely abrogate the FcgammaR-induced superoxide response, correlating with a decrease in Cbl and Nck tyrosine phosphorylation.	Superoxides	85-95	Cbl proto-oncogene	Homo sapiens	137-140
9843681-13	1998	This pathway may regulate multiple downstream events in hematopoietic cells, including Rac-induced lamellipodia formation, tyrosine phosphorylation of Cbl, and activation of JNK, ERK2 and the phosphatidylinositol 3"-kinase-regulated kinase Akt.	Tyrosine	123-131	Cbl proto-oncogene	Homo sapiens	151-154
9830044-6	1998	We show that ligation of Ly49D results in 1) tyrosine phosphorylation of several substrates, including phospholipase Cgamma1, Cbl, and p44/p42 mitogen-activated protein kinase, and 2) calcium mobilization.	Tyrosine	45-53	Cbl proto-oncogene	Homo sapiens	126-129
9794375-2	1998	Engagement of any of these receptors induces the rapid tyrosine phosphorylation of a shared group of intracellular signaling proteins, including Vav, Cbl, p85 phosphoinositide 3-kinase, and the Src family kinases Lck and Fyn.	Tyrosine	55-63	Cbl proto-oncogene	Homo sapiens	150-153
9845379-0	1998	c-Cbl tyrosine phosphorylation and subcellular localization in human primary leukemic cells.	Tyrosine	6-14	Cbl proto-oncogene	Homo sapiens	0-5
9845379-2	1998	In this study we show that the product of the proto-oncogene c-Cbl, whose function is still unknown, is constitutively tyrosine phosphorylated not only in cells from chronic myelogenous leukemias (CMLs) in the blast phase, but also in cells from acute myeloblastic leukemias (AMLs), Ph-negative acute T-lymphoblastic leukemias (T-ALLs), and Ph-negative pre-B lymphoblastic leukemias (pre-B ALL).	Tyrosine	119-127	Cbl proto-oncogene	Homo sapiens	46-66
9845379-7	1998	Our findings that c-Cbl is constitutively tyrosine phosphorylated and associated with the detergent-insoluble fraction in AML and ALL blasts and in PMNs from CML patients suggest that this event represents a common step in the neoplastic transformation of both myeloid and lymphoid progenitor cells.	Tyrosine	42-50	Cbl proto-oncogene	Homo sapiens	18-23
9820532-4	1998	Fc gamma RI cross-linking of U937IF cells results in the tyrosine phosphorylation of Cbl, Crkl, and Hef-1, an increase in the association of Crkl with Cbl via direct SH2 domain interaction and increased Crkl-Hef-1 binding.	Tyrosine	57-65	Cbl proto-oncogene	Homo sapiens	85-88
9894838-3	1998	Peptide sequences resembling this consensus were identified in two signal transduction proteins, c-Cbl and son-on-sevenless (Sos), previously shown to interact with the C-terminal SH3 domain of CAP.	sulfur monoxide	125-128	Cbl proto-oncogene	Homo sapiens	97-102
9894838-5	1998	Alanine-scanning mutagenesis of the c-Cbl peptide ligand confirmed that most of the residues, which were conserved among the peptide ligands selected from the combinatorial peptide library, contributed to binding to the C-terminal SH3 domain of CAP.	Alanine	0-7	Cbl proto-oncogene	Homo sapiens	36-41
9716598-1	1998	SLP-76 and Cbl are complex adapter proteins that have the capacity to bind to smaller adapter proteins, such as Grb2, which subsequently binds the nucleotide exchange protein Sos in the transmission of intracellular signals.	sulfur monoxide	175-178	Cbl proto-oncogene	Homo sapiens	11-14
9716598-10	1998	FcgammaRI-induced tyrosine phosphorylation of SLP-76, Cbl, Shc, and the highly induced SLP-76-Shc interaction provide the first evidence that SLP-76 and Cbl are involved in FcgammaRI signaling and suggest a functional significance for these interactions in FcgammaRI signal relay in the control of Ras in myeloid cells.	Tyrosine	18-26	Cbl proto-oncogene	Homo sapiens	153-156
9797470-2	1998	c-Cbl possesses a highly conserved N-terminal phosphotyrosine binding domain, a C3HC4 RING finger motif, multiple proline-rich motifs, and a number of potential tyrosine phosphorylation sites.	Phosphotyrosine	46-61	Cbl proto-oncogene	Homo sapiens	0-5
9797470-2	1998	c-Cbl possesses a highly conserved N-terminal phosphotyrosine binding domain, a C3HC4 RING finger motif, multiple proline-rich motifs, and a number of potential tyrosine phosphorylation sites.	c3hc4	80-85	Cbl proto-oncogene	Homo sapiens	0-5
9797470-2	1998	c-Cbl possesses a highly conserved N-terminal phosphotyrosine binding domain, a C3HC4 RING finger motif, multiple proline-rich motifs, and a number of potential tyrosine phosphorylation sites.	Proline	114-121	Cbl proto-oncogene	Homo sapiens	0-5
9797470-2	1998	c-Cbl possesses a highly conserved N-terminal phosphotyrosine binding domain, a C3HC4 RING finger motif, multiple proline-rich motifs, and a number of potential tyrosine phosphorylation sites.	Tyrosine	53-61	Cbl proto-oncogene	Homo sapiens	0-5
9716598-2	1998	SLP-76, Cbl, Shc, and Grb2 have been implicated in immunoreceptor tyrosine-based activation motif (ITAM) signaling, leading to activation of Ras.	Tyrosine	66-74	Cbl proto-oncogene	Homo sapiens	8-11
9716598-5	1998	We provide evidence that SLP-76, Cbl, and Shc are tyrosine phosphorylated on FcgammaRI-receptor stimulation and are associated with the adapter protein Grb2 in gamma-interferon-differentiated U937 cells (U937IF).	Tyrosine	50-58	Cbl proto-oncogene	Homo sapiens	33-36
9731483-5	1998	In the BLM gene, we found a frameshift mutation in a polyadenine repeat, whereas in the CBL proto-oncogene, an expansion of a trinucleotide repeat was detected with no translation shift.	trinucleotide	126-139	Cbl proto-oncogene	Homo sapiens	88-91
9712732-6	1998	The interaction of this extended PLCgamma1 SH3 domain fusion protein with Cbl was shown to depend entirely upon the interaction of the domain with a proline-rich motif in Cbl, ruling out the possibility that amino acids adjacent to the core SH3 domain of PLCgamma1 provide independent Cbl binding.	Proline	149-156	Cbl proto-oncogene	Homo sapiens	74-77
9687507-2	1998	Following ligation of surface integrins by fibronectin, the p120(c-cbl) (Cbl) protein rapidly becomes tyrosine phosphorylated and associated with the Src-family kinases Fgr and Lyn.	Tyrosine	102-110	Cbl proto-oncogene	Homo sapiens	60-70
9687507-2	1998	Following ligation of surface integrins by fibronectin, the p120(c-cbl) (Cbl) protein rapidly becomes tyrosine phosphorylated and associated with the Src-family kinases Fgr and Lyn.	Tyrosine	102-110	Cbl proto-oncogene	Homo sapiens	73-76
9678765-0	1998	Co-stimulation of T cells with CD2 augments TCR-CD3-mediated activation of protein tyrosine kinase p72syk, resulting in increased tyrosine phosphorylation of adapter proteins, Shc and Cbl.	Tyrosine	83-91	Cbl proto-oncogene	Homo sapiens	184-187
9663390-6	1998	Mutations of the CD28 cytoplasmic domain that blocked integrin activation also impaired the tyrosine phosphorylation of the Cbl adaptor protein and the activation of the PI 3-kinase that was associated with Cbl.	Tyrosine	92-100	Cbl proto-oncogene	Homo sapiens	124-127
9614102-2	1998	We have found that CBLB, a recently characterized molecule closely related to the CBL protooncogene product, is phosphorylated on tyrosine(s) following FL treatment of JEA2 human pro-B cells and THP1 monocytic cells.	Tyrosine	130-138	Cbl proto-oncogene	Homo sapiens	19-22
9614102-2	1998	We have found that CBLB, a recently characterized molecule closely related to the CBL protooncogene product, is phosphorylated on tyrosine(s) following FL treatment of JEA2 human pro-B cells and THP1 monocytic cells.	fl	152-154	Cbl proto-oncogene	Homo sapiens	19-22
9678765-7	1998	Furthermore, CD2 co-stimulation with CD3 resulted in enhanced tyrosine phosphorylation of adapter proteins, such as Shc and Cbl, in an antibody concentration-dependent manner.	Tyrosine	62-70	Cbl proto-oncogene	Homo sapiens	124-127
9590251-0	1998	CBL-GRB2 interaction in myeloid immunoreceptor tyrosine activation motif signaling.	Tyrosine	47-55	Cbl proto-oncogene	Homo sapiens	0-3
9590251-4	1998	Fc gammaRI cross-linking of U937IF cells induces the tyrosine phosphorylation of CBL that is associated with an altered CBL-GRB2 interaction.	Tyrosine	53-61	Cbl proto-oncogene	Homo sapiens	81-84
9590251-4	1998	Fc gammaRI cross-linking of U937IF cells induces the tyrosine phosphorylation of CBL that is associated with an altered CBL-GRB2 interaction.	Tyrosine	53-61	Cbl proto-oncogene	Homo sapiens	120-123
9569238-4	1998	Among these proteins, tyrosine phosphorylation of the 105 kD and 115 kD proteins and the product of the c-cbl protooncogene, Cbl, was specifically inhibited using soluble anti-CD18 monoclonal antibody (mAb) to block eosinophil cell adhesion.	Tyrosine	22-30	Cbl proto-oncogene	Homo sapiens	104-109
9569238-4	1998	Among these proteins, tyrosine phosphorylation of the 105 kD and 115 kD proteins and the product of the c-cbl protooncogene, Cbl, was specifically inhibited using soluble anti-CD18 monoclonal antibody (mAb) to block eosinophil cell adhesion.	Tyrosine	22-30	Cbl proto-oncogene	Homo sapiens	125-128
9569238-7	1998	We found that direct ligation of eosinophil alphaM beta2 with anti-CD11b mAb coupled to polystyrene microbeads induced tyrosine phosphorylation of a 115 kD protein and Cbl.	Polystyrenes	88-99	Cbl proto-oncogene	Homo sapiens	168-171
9564040-8	1998	In PKC depleted cells, Ang II stimulated Shc and Cbl tyrosine phosphorylation, suggesting that without PKC, Ang II activates another tyrosine kinase.	Tyrosine	53-61	Cbl proto-oncogene	Homo sapiens	49-52
9535867-7	1998	This mechanism appears to involve Fyn, since, in addition to its association with the C-terminal region of Cbl, Fyn also associated with Syk and enhanced the Syk-induced tyrosine phosphorylation of Cbl.	Tyrosine	170-178	Cbl proto-oncogene	Homo sapiens	198-201
9580611-1	1998	Recent reports indicate that oxidized cobalamin, Cbl(III), can interfere with the biological effects of nitric oxide (NO) on vascular and visceral smooth muscle and in other systems.	Vitamin B 12	38-47	Cbl proto-oncogene	Homo sapiens	49-52
9580611-1	1998	Recent reports indicate that oxidized cobalamin, Cbl(III), can interfere with the biological effects of nitric oxide (NO) on vascular and visceral smooth muscle and in other systems.	Nitric Oxide	104-116	Cbl proto-oncogene	Homo sapiens	49-52
9580611-8	1998	Nitric oxide also reacts rapidly and irreversibly with the superoxo complex of Cbl(III), Cbl(III)O2-, which is always present in aerated solutions of Cbl(III).	Nitric Oxide	0-12	Cbl proto-oncogene	Homo sapiens	79-82
9580611-8	1998	Nitric oxide also reacts rapidly and irreversibly with the superoxo complex of Cbl(III), Cbl(III)O2-, which is always present in aerated solutions of Cbl(III).	Nitric Oxide	0-12	Cbl proto-oncogene	Homo sapiens	89-92
9580611-8	1998	Nitric oxide also reacts rapidly and irreversibly with the superoxo complex of Cbl(III), Cbl(III)O2-, which is always present in aerated solutions of Cbl(III).	Nitric Oxide	0-12	Cbl proto-oncogene	Homo sapiens	89-92
9580611-10	1998	Because Cbl(III)O2- is spontaneously regenerated from Cbl(II) and O2 in aerated solutions, this may constitute a cyclic mechanism for the rapid elimination (oxidation) of NO.	Oxygen	16-18	Cbl proto-oncogene	Homo sapiens	8-11
9564040-10	1998	In PKC-depleted cells, EGF receptor-specific tyrosine kinase inhibitors blocked Ang II-dependent EGF receptor and Cbl tyrosine phosphorylation, and ERK activation.	Tyrosine	45-53	Cbl proto-oncogene	Homo sapiens	114-117
9535867-0	1998	Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases.	Tyrosine	30-38	Cbl proto-oncogene	Homo sapiens	58-61
9535867-5	1998	Tyr-316 of Syk was required for the interaction with Cbl as well as for the maximal tyrosine phosphorylation of Cbl.	Tyrosine	0-3	Cbl proto-oncogene	Homo sapiens	53-56
9535867-5	1998	Tyr-316 of Syk was required for the interaction with Cbl as well as for the maximal tyrosine phosphorylation of Cbl.	Tyrosine	0-3	Cbl proto-oncogene	Homo sapiens	112-115
9535867-8	1998	These findings implicate Fyn as an adaptor protein that facilitates the interaction between Syk and Cbl, and suggest that Src and Syk family PTKs coordinately regulate the tyrosine phosphorylation of Cbl.	Tyrosine	172-180	Cbl proto-oncogene	Homo sapiens	200-203
9535867-5	1998	Tyr-316 of Syk was required for the interaction with Cbl as well as for the maximal tyrosine phosphorylation of Cbl.	Tyrosine	84-92	Cbl proto-oncogene	Homo sapiens	112-115
9535867-6	1998	However, both wild-type Syk and Y316F-mutated Syk phosphorylated equally well the C-terminal fragment of Cbl in vivo, suggesting the existence of an alternative, N terminus-independent mechanism for the Syk-induced tyrosine phosphorylation of Cbl.	Tyrosine	215-223	Cbl proto-oncogene	Homo sapiens	105-108
9508241-1	1998	Recent studies have identified a (CCG)n repeat in the 5" untranslated region of the CBL2 protooncogene (11q23.3) and have demonstrated that expansion of this repeat causes expression of the folate-sensitive fragile site FRA11B.	Folic Acid	190-196	Cbl proto-oncogene	Homo sapiens	84-88
9535867-7	1998	This mechanism appears to involve Fyn, since, in addition to its association with the C-terminal region of Cbl, Fyn also associated with Syk and enhanced the Syk-induced tyrosine phosphorylation of Cbl.	Tyrosine	170-178	Cbl proto-oncogene	Homo sapiens	107-110
9525940-0	1998	Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells.	Tyrosine	65-73	Cbl proto-oncogene	Homo sapiens	43-48
9525940-1	1998	Protooncogenic protein c-Cbl undergoes tyrosine phosphorylation in response to stimulation through the receptors for antigens, immunoglobulins, cytokines, and growth factors as well as through the integrins.	Tyrosine	39-47	Cbl proto-oncogene	Homo sapiens	23-28
9525940-2	1998	Tyrosine phosphorylation of c-Cbl may play a functional role in signal transduction, since c-Cbl interacts with many crucial signaling molecules including protein-tyrosine kinases, adaptor proteins, and phosphatidylinositol 3"-kinase.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	28-33
9525940-2	1998	Tyrosine phosphorylation of c-Cbl may play a functional role in signal transduction, since c-Cbl interacts with many crucial signaling molecules including protein-tyrosine kinases, adaptor proteins, and phosphatidylinositol 3"-kinase.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	91-96
9525940-3	1998	Therefore, it is essential for our understanding of the functions of c-Cbl in signal transduction to identify its tyrosine phosphorylation sites, to determine the protein-tyrosine kinases that phosphorylate these sites, and to elucidate the role of these sites in the interactions of c-Cbl with other signaling proteins.	Tyrosine	114-122	Cbl proto-oncogene	Homo sapiens	69-74
9525940-4	1998	In this report, we demonstrate that tyrosines 700, 731, and 774 are the major tyrosine phosphorylation sites of c-Cbl in T cells in response to pervanadate treatment, as well as in response to TcR/CD3 ligation.	Tyrosine	36-45	Cbl proto-oncogene	Homo sapiens	112-117
9525940-4	1998	In this report, we demonstrate that tyrosines 700, 731, and 774 are the major tyrosine phosphorylation sites of c-Cbl in T cells in response to pervanadate treatment, as well as in response to TcR/CD3 ligation.	Tyrosine	36-44	Cbl proto-oncogene	Homo sapiens	112-117
9525940-7	1998	Among these kinases, Fyn and Yes demonstrate strong binding to c-Cbl, which involves both phosphotyrosine-dependent and phosphotyrosine-independent mechanisms.	Phosphotyrosine	90-105	Cbl proto-oncogene	Homo sapiens	63-68
9525940-7	1998	Among these kinases, Fyn and Yes demonstrate strong binding to c-Cbl, which involves both phosphotyrosine-dependent and phosphotyrosine-independent mechanisms.	Phosphotyrosine	120-135	Cbl proto-oncogene	Homo sapiens	63-68
9508241-1	1998	Recent studies have identified a (CCG)n repeat in the 5" untranslated region of the CBL2 protooncogene (11q23.3) and have demonstrated that expansion of this repeat causes expression of the folate-sensitive fragile site FRA11B.	Folic Acid	190-196	Cbl proto-oncogene	Homo sapiens	220-226
9541596-0	1998	CD16-mediated activation of phosphatidylinositol-3 kinase (PI-3K) in human NK cells involves tyrosine phosphorylation of Cbl and its association with Grb2, Shc, pp36 and p85 PI-3K subunit.	Tyrosine	93-101	Cbl proto-oncogene	Homo sapiens	121-124
9541596-4	1998	Our results indicate that stimulation of NK cells through CD16 results in a rapid tyrosine phosphorylation of Cbl, which is constitutively associated with Grb2 and forms an activation-dependent complex with the p85 subunit of Pl-3K.	Tyrosine	82-90	Cbl proto-oncogene	Homo sapiens	110-113
9541596-5	1998	In addition, we detected the presence of the Grb2-associated tyrosine-phosphorylated p36 and Shc proteins in anti-Cbl and anti-p85 immunoprecipitates from CD16-stimulated NK cell lysates.	Tyrosine	61-69	Cbl proto-oncogene	Homo sapiens	114-117
9407100-3	1997	We recently identified a phosphotyrosine binding (PTB) domain residing within the N-terminal transforming region of Cbl (Cbl-N), which mediated direct binding to ZAP-70 tyrosine kinase.	Phosphotyrosine	25-40	Cbl proto-oncogene	Homo sapiens	116-119
9529123-7	1998	Following FL stimulation, a concomitant increase in both CBL phosphorylation and complex formation with p85 subunit of phosphatidylinositol 3" kinase is observed.	fl	10-12	Cbl proto-oncogene	Homo sapiens	57-60
9529123-9	1998	FL-inducible binding of CBL to the CRKII adaptor molecule is also demonstrated.	fl	0-2	Cbl proto-oncogene	Homo sapiens	24-27
9414268-0	1998	c-Cbl is tyrosine-phosphorylated by interleukin-4 and enhances mitogenic and survival signals of interleukin-4 receptor by linking with the phosphatidylinositol 3"-kinase pathway.	Tyrosine	9-17	Cbl proto-oncogene	Homo sapiens	0-5
9414268-3	1998	In this study, we demonstrated that c-Cbl proto-oncogene product is inducibly phosphorylated on tyrosine residues and is associated with the p85 subunit of PI3-kinase by IL-4 stimulation.	Tyrosine	96-104	Cbl proto-oncogene	Homo sapiens	36-41
9414268-5	1998	However, these effects of c-Cbl were abolished by wortmannin, a specific inhibitor for the PI3 kinase pathway, or by a point mutation at tyrosine 731 of c-Cbl, which is a major binding site for p85.	Wortmannin	50-60	Cbl proto-oncogene	Homo sapiens	26-31
9414268-5	1998	However, these effects of c-Cbl were abolished by wortmannin, a specific inhibitor for the PI3 kinase pathway, or by a point mutation at tyrosine 731 of c-Cbl, which is a major binding site for p85.	Tyrosine	137-145	Cbl proto-oncogene	Homo sapiens	26-31
9414268-5	1998	However, these effects of c-Cbl were abolished by wortmannin, a specific inhibitor for the PI3 kinase pathway, or by a point mutation at tyrosine 731 of c-Cbl, which is a major binding site for p85.	Tyrosine	137-145	Cbl proto-oncogene	Homo sapiens	153-158
9461587-0	1998	Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells.	Tyrosine	34-42	Cbl proto-oncogene	Homo sapiens	67-70
9461587-1	1998	Interleukin (IL)-2, a major growth and differentiation factor for T lymphocytes, was found to induce tyrosine phosphorylation of the proto-oncogene products p120-Cbl and CrkL in IL-2-dependent cell lines.	Tyrosine	101-109	Cbl proto-oncogene	Homo sapiens	162-165
9461587-4	1998	In addition, we demonstrate that the SH2-SH3-SH3 adaptor protein CrkL is tyrosine-phosphorylated in an IL-2-dependent manner and, via its SH2 domain, associates with a large proportion of phosphorylated Cbl.	Tyrosine	73-81	Cbl proto-oncogene	Homo sapiens	203-206
9461587-8	1998	Although the precise roles of Cbl and CrkL remain to be elucidated, their tyrosine phosphorylation, in addition to the multiple protein interactions described here, strongly suggest that Cbl and CrkL may play pivotal roles in the early steps of IL-2 signal transduction.	Tyrosine	74-82	Cbl proto-oncogene	Homo sapiens	187-190
9447983-1	1998	The protein product of the c-Cbl proto-oncogene is prominently tyrosine phosphorylated in response to insulin in 3T3-L1 adipocytes and not in 3T3-L1 fibroblasts.	Tyrosine	63-71	Cbl proto-oncogene	Homo sapiens	27-32
9447983-2	1998	After insulin-dependent tyrosine phosphorylation, c-Cbl specifically associates with endogenous c-Crk and Fyn.	Tyrosine	24-32	Cbl proto-oncogene	Homo sapiens	50-55
9447983-3	1998	These results suggest a role for tyrosine-phosphorylated c-Cbl in 3T3-L1 adipocyte activation by insulin.	Tyrosine	33-41	Cbl proto-oncogene	Homo sapiens	57-62
9407100-0	1997	The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.	Phosphotyrosine	8-23	Cbl proto-oncogene	Homo sapiens	4-7
9428519-6	1997	Finally, we show that the 14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl.	Phosphoserine	102-115	Cbl proto-oncogene	Homo sapiens	220-223
9407100-3	1997	We recently identified a phosphotyrosine binding (PTB) domain residing within the N-terminal transforming region of Cbl (Cbl-N), which mediated direct binding to ZAP-70 tyrosine kinase.	Phosphotyrosine	25-40	Cbl proto-oncogene	Homo sapiens	121-126
9407100-5	1997	A phosphopeptide predicted by this motif and corresponding to the in vivo negative regulatory phosphorylation site of ZAP-70 (Tyr(P)292) specifically inhibited binding of ZAP-70 to Cbl-N.	Tyrosine	126-129	Cbl proto-oncogene	Homo sapiens	181-186
9434624-4	1997	We show that orthovanadate and PAO augmented the Fc gamma RI-induced tyrosine phosphorylation of the adaptor protein CBL.	Vanadates	13-26	Cbl proto-oncogene	Homo sapiens	117-120
9434624-4	1997	We show that orthovanadate and PAO augmented the Fc gamma RI-induced tyrosine phosphorylation of the adaptor protein CBL.	oxophenylarsine	31-34	Cbl proto-oncogene	Homo sapiens	117-120
9434624-4	1997	We show that orthovanadate and PAO augmented the Fc gamma RI-induced tyrosine phosphorylation of the adaptor protein CBL.	Tyrosine	69-77	Cbl proto-oncogene	Homo sapiens	117-120
9341192-6	1997	In addition, osmotic shock induced the tyrosine phosphorylation of several discrete proteins including Cbl, p130(cas), and the recently identified soluble tyrosine kinase, calcium-dependent tyrosine kinase (CADTK).	Tyrosine	39-47	Cbl proto-oncogene	Homo sapiens	103-106
9400833-0	1997	Agonist-specific tyrosine phosphorylation of Cbl in human neutrophils.	Tyrosine	17-25	Cbl proto-oncogene	Homo sapiens	45-48
9400833-1	1997	The effects of soluble and particulate agonists on the tyrosine phosphorylation levels of the proto-oncogene Cbl in human neutrophils were examined.	Tyrosine	55-63	Cbl proto-oncogene	Homo sapiens	109-112
9400833-3	1997	Their use allowed us to observe that Cbl was tyrosine phosphorylated in response to some (FcgammaRII ligation, opsonized bacteria and zymosan, granulocyte-macrophage colony-stimulating factor, monosodium urate, and calcium pyrophosphate microcrystals), but not all (fMet-Leu-Phe, interleukin-8) neutrophil agonists.	Tyrosine	45-53	Cbl proto-oncogene	Homo sapiens	37-40
9400833-3	1997	Their use allowed us to observe that Cbl was tyrosine phosphorylated in response to some (FcgammaRII ligation, opsonized bacteria and zymosan, granulocyte-macrophage colony-stimulating factor, monosodium urate, and calcium pyrophosphate microcrystals), but not all (fMet-Leu-Phe, interleukin-8) neutrophil agonists.	Zymosan	134-141	Cbl proto-oncogene	Homo sapiens	37-40
9400833-3	1997	Their use allowed us to observe that Cbl was tyrosine phosphorylated in response to some (FcgammaRII ligation, opsonized bacteria and zymosan, granulocyte-macrophage colony-stimulating factor, monosodium urate, and calcium pyrophosphate microcrystals), but not all (fMet-Leu-Phe, interleukin-8) neutrophil agonists.	Uric Acid	193-209	Cbl proto-oncogene	Homo sapiens	37-40
9400833-3	1997	Their use allowed us to observe that Cbl was tyrosine phosphorylated in response to some (FcgammaRII ligation, opsonized bacteria and zymosan, granulocyte-macrophage colony-stimulating factor, monosodium urate, and calcium pyrophosphate microcrystals), but not all (fMet-Leu-Phe, interleukin-8) neutrophil agonists.	Calcium Pyrophosphate	215-236	Cbl proto-oncogene	Homo sapiens	37-40
9400833-3	1997	Their use allowed us to observe that Cbl was tyrosine phosphorylated in response to some (FcgammaRII ligation, opsonized bacteria and zymosan, granulocyte-macrophage colony-stimulating factor, monosodium urate, and calcium pyrophosphate microcrystals), but not all (fMet-Leu-Phe, interleukin-8) neutrophil agonists.	N-Formylmethionine	266-270	Cbl proto-oncogene	Homo sapiens	37-40
9400833-3	1997	Their use allowed us to observe that Cbl was tyrosine phosphorylated in response to some (FcgammaRII ligation, opsonized bacteria and zymosan, granulocyte-macrophage colony-stimulating factor, monosodium urate, and calcium pyrophosphate microcrystals), but not all (fMet-Leu-Phe, interleukin-8) neutrophil agonists.	leucyl-phenylalanine	271-278	Cbl proto-oncogene	Homo sapiens	37-40
9400833-5	1997	These data establish that Cbl is present in human neutrophils and that its level of tyrosine phosphorylation is modulated by some of these cells" agonists, and in particular by phagocytic particles.	Tyrosine	84-92	Cbl proto-oncogene	Homo sapiens	26-29
9400833-6	1997	Furthermore, the signaling pathways activated by chemotactic factors and the other neutrophil stimuli tested in this investigation diverge at or downstream from the tyrosine phosphorylation of Cbl.	Tyrosine	165-173	Cbl proto-oncogene	Homo sapiens	193-196
9341192-7	1997	In contrast, insulin had no effect on CADTK but stimulated the tyrosine phosphorylation of Cbl and the tyrosine dephosphorylation of pp125(FAK) and p130(cas).	Tyrosine	63-71	Cbl proto-oncogene	Homo sapiens	91-94
9311917-3	1997	The adapter protein CrkL was associated with both phosphorylated Cbl and the guanidine nucleotide-releasing factor C3G, which catalyzes guanosine triphosphate (GTP) exchange on Rap1.	Guanosine Triphosphate	160-163	Cbl proto-oncogene	Homo sapiens	65-68
9200454-3	1997	CD38 ligation also triggers tyrosine phosphorylation of syk, c-cbl, and phospholipase C-gamma and activates phosphatidylinositol 3-kinase (PI3-K).	Tyrosine	28-36	Cbl proto-oncogene	Homo sapiens	61-66
9242692-6	1997	Moreover, we show that tyrosine phosphorylation of the Cbl protooncogene product as well as Gab1 required Tyr489 and correlated with the ability of Tpr-Met to associate with Grb2 and to transform cells, providing evidence that pathways downstream of Gab1 and/or Cbl may play a role in Tpr-Met-mediated cell transformation.	Tyrosine	23-31	Cbl proto-oncogene	Homo sapiens	55-58
9242692-6	1997	Moreover, we show that tyrosine phosphorylation of the Cbl protooncogene product as well as Gab1 required Tyr489 and correlated with the ability of Tpr-Met to associate with Grb2 and to transform cells, providing evidence that pathways downstream of Gab1 and/or Cbl may play a role in Tpr-Met-mediated cell transformation.	Tyrosine	23-31	Cbl proto-oncogene	Homo sapiens	262-265
9259313-1	1997	Stimulation of Nb2 cells with PRL results in the rapid phosphorylation of a 120-kDa protein identified as the adapter protein cbl on tyrosine residues.	Tyrosine	133-141	Cbl proto-oncogene	Homo sapiens	126-129
9259313-10	1997	Our model suggests that the p85 subunit of PI 3-kinase is constitutively associated with cbl through binding of the p85 SH3 domain to a proline-rich sequence in cbl.	Proline	136-143	Cbl proto-oncogene	Homo sapiens	89-92
9259313-10	1997	Our model suggests that the p85 subunit of PI 3-kinase is constitutively associated with cbl through binding of the p85 SH3 domain to a proline-rich sequence in cbl.	Proline	136-143	Cbl proto-oncogene	Homo sapiens	161-164
9259313-11	1997	After the tyrosine phosphorylation of cbl, an SH2 domain(s) of p85 binds to a specific phosphorylation site(s) in cbl, leading to the activation of PI 3-kinase.	Tyrosine	10-18	Cbl proto-oncogene	Homo sapiens	38-41
9259313-11	1997	After the tyrosine phosphorylation of cbl, an SH2 domain(s) of p85 binds to a specific phosphorylation site(s) in cbl, leading to the activation of PI 3-kinase.	Tyrosine	10-18	Cbl proto-oncogene	Homo sapiens	114-117
9200454-7	1997	Ligation of either CD38 or CD19 resulted in a similar pattern of protein tyrosine phosphorylation; both signaling pathways caused tyrosine phosphorylation of c-cbl.	Tyrosine	130-138	Cbl proto-oncogene	Homo sapiens	158-163
9210408-0	1997	Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes.	Tyrosine	19-27	Cbl proto-oncogene	Homo sapiens	77-82
9195915-5	1997	This interaction only occurs under conditions where c-CBL is tyrosine-phosphorylated.	Tyrosine	61-69	Cbl proto-oncogene	Homo sapiens	52-57
9195915-7	1997	Since CRKL, an SH2, SH3 domain-containing adapter protein is known to bind directly to BCR-ABL and also binds to tyrosine-phosphorylated c-CBL, the ability of CRKL to mediate a complex between c-CBL and BCR-ABL was examined.	Tyrosine	113-121	Cbl proto-oncogene	Homo sapiens	137-142
9195915-7	1997	Since CRKL, an SH2, SH3 domain-containing adapter protein is known to bind directly to BCR-ABL and also binds to tyrosine-phosphorylated c-CBL, the ability of CRKL to mediate a complex between c-CBL and BCR-ABL was examined.	Tyrosine	113-121	Cbl proto-oncogene	Homo sapiens	193-198
9210408-1	1997	We report here that the product of the c-Cbl proto-oncogene is prominently tyrosine phosphorylated in response to insulin in 3T3-L1 adipocytes.	Tyrosine	75-83	Cbl proto-oncogene	Homo sapiens	39-44
9210408-2	1997	The tyrosine phosphorylation of c-Cbl reaches a maximum within 1-2 min after stimulation by insulin and gradually declines thereafter.	Tyrosine	4-12	Cbl proto-oncogene	Homo sapiens	32-37
9210408-3	1997	The tyrosine phosphorylation of c-Cbl was also observed after treatment of 3T3-L1 adipocytes with epidermal growth factor, whereas platelet-derived growth factor had no effect.	Tyrosine	4-12	Cbl proto-oncogene	Homo sapiens	32-37
9210408-4	1997	After insulin-dependent tyrosine phosphorylation, c-Cbl specifically associates with fusion proteins containing the Src homology 2 (SH2) domains of Crk and the Fyn tyrosine kinase, but not with fusion proteins containing the SH2 domains of either the p85 subunit of phosphatidylinositol 3"-kinase or the tyrosine phosphatase SHPTP2/Syp.	Tyrosine	24-32	Cbl proto-oncogene	Homo sapiens	50-55
9210408-6	1997	The tyrosine phosphorylation of c-Cbl is regulated during adipocyte differentiation.	Tyrosine	4-12	Cbl proto-oncogene	Homo sapiens	32-37
9162067-5	1997	The major tyrosine-phosphorylated CRKL-binding protein in the megakaryocytic MO7e cells was identified as p120(CBL), the cellular homolog of the v-Cbl oncoprotein.	Tyrosine	10-18	Cbl proto-oncogene	Homo sapiens	111-114
9162067-5	1997	The major tyrosine-phosphorylated CRKL-binding protein in the megakaryocytic MO7e cells was identified as p120(CBL), the cellular homolog of the v-Cbl oncoprotein.	Tyrosine	10-18	Cbl proto-oncogene	Homo sapiens	147-150
9162067-8	1997	Interestingly, although both MO7e and H9 cells express p120(CBL) and p110(HEF1), beta1 integrin cross-linking induces tyrosine phosphorylation of p120(CBL) (but not p110(HEF1)) in MO7e cells and of p110(HEF1) (but not p120(CBL)) in H9 cells.	Tyrosine	118-126	Cbl proto-oncogene	Homo sapiens	151-154
9192738-2	1997	We previously reported that the ligation of CD38 by a monoclonal antibody (mAb), HB-7, induces the tyrosine phosphorylation of cellular proteins including p120(c-cbl) in differentiated human myeloid cell lines and that the phosphorylated p120(c-cbl) is capable of binding to phosphatidylinositol (PI) 3-kinase.	Tyrosine	99-107	Cbl proto-oncogene	Homo sapiens	160-165
9222284-4	1997	The CBL-LD50 mean values were significantly reduced at all PDN and at the 4 highest DFZ concentrations.	deflazacort	84-87	Cbl proto-oncogene	Homo sapiens	4-7
9192738-2	1997	We previously reported that the ligation of CD38 by a monoclonal antibody (mAb), HB-7, induces the tyrosine phosphorylation of cellular proteins including p120(c-cbl) in differentiated human myeloid cell lines and that the phosphorylated p120(c-cbl) is capable of binding to phosphatidylinositol (PI) 3-kinase.	Phosphatidylinositols	275-295	Cbl proto-oncogene	Homo sapiens	160-165
9092538-0	1997	Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif.	Serine	0-6	Cbl proto-oncogene	Homo sapiens	26-29
9092538-0	1997	Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif.	Phorbol Esters	41-54	Cbl proto-oncogene	Homo sapiens	26-29
9092538-0	1997	Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif.	Serine	124-130	Cbl proto-oncogene	Homo sapiens	26-29
9092538-1	1997	Stimulation of the T cell antigen receptor (TCR).CD3 complex induces rapid tyrosine phosphorylation of Cbl, a protooncogene product which has been implicated in intracellular signaling pathways via its interaction with several signaling molecules.	Tyrosine	75-83	Cbl proto-oncogene	Homo sapiens	103-106
9092538-3	1997	We report here that phorbol 12-myristate 13-acetate stimulation of T cells also enhanced the interaction between Cbl and two 14-3-3 isoforms (tau and zeta).	Tetradecanoylphorbol Acetate	20-51	Cbl proto-oncogene	Homo sapiens	113-154
9092538-4	1997	Tyrosine phosphorylation of Cbl was not sufficient or required for this increased interaction.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	28-31
9092538-5	1997	Thus, cotransfection of COS cells with Cbl plus Lck and/or Syk family protein-tyrosine kinases caused a marked increase in the phosphotyrosine content of Cbl without a concomitant enhancement of its association with 14-3-3.	Phosphotyrosine	127-142	Cbl proto-oncogene	Homo sapiens	39-42
9092538-5	1997	Thus, cotransfection of COS cells with Cbl plus Lck and/or Syk family protein-tyrosine kinases caused a marked increase in the phosphotyrosine content of Cbl without a concomitant enhancement of its association with 14-3-3.	Phosphotyrosine	127-142	Cbl proto-oncogene	Homo sapiens	154-157
9092538-6	1997	Phorbol 12-myristate 13-acetate stimulation induced serine phosphorylation of Cbl, and dephosphorylation of immunoprecipitated Cbl by a Ser/Thr phosphatase disrupted its interaction with 14-3-3.	Tetradecanoylphorbol Acetate	0-31	Cbl proto-oncogene	Homo sapiens	78-81
9092538-6	1997	Phorbol 12-myristate 13-acetate stimulation induced serine phosphorylation of Cbl, and dephosphorylation of immunoprecipitated Cbl by a Ser/Thr phosphatase disrupted its interaction with 14-3-3.	Tetradecanoylphorbol Acetate	0-31	Cbl proto-oncogene	Homo sapiens	127-130
9092538-6	1997	Phorbol 12-myristate 13-acetate stimulation induced serine phosphorylation of Cbl, and dephosphorylation of immunoprecipitated Cbl by a Ser/Thr phosphatase disrupted its interaction with 14-3-3.	Serine	52-58	Cbl proto-oncogene	Homo sapiens	78-81
9092538-7	1997	By using successive carboxyl-terminal deletion mutants of Cbl, the 14-3-3-binding domain was mapped to a serine-rich 30-amino acid region (residues 615-644) of Cbl.	Serine	105-111	Cbl proto-oncogene	Homo sapiens	58-61
9092538-7	1997	By using successive carboxyl-terminal deletion mutants of Cbl, the 14-3-3-binding domain was mapped to a serine-rich 30-amino acid region (residues 615-644) of Cbl.	Serine	105-111	Cbl proto-oncogene	Homo sapiens	160-163
9092538-9	1997	These results suggest that TCR stimulation induces both tyrosine and serine phosphorylation of Cbl.	Serine	69-75	Cbl proto-oncogene	Homo sapiens	95-98
9209406-6	1997	The amino-acid sequence analysis showed that the pp130 was identical to the human c-cbl proto-oncogene product (c-Cbl).	pp130	49-54	Cbl proto-oncogene	Homo sapiens	82-117
9103201-4	1997	Overexpression of Cbl led to inhibition of Syk and suppression of serotonin release from mast cells, demonstrating its ability to inhibit a nonreceptor tyrosine kinase.	Serotonin	66-75	Cbl proto-oncogene	Homo sapiens	18-21
9108397-2	1997	To investigate the signaling processes induced by thrombopoietin, we have employed human platelets and recently demonstrated that thrombopoietin induces rapid tyrosine phosphorylation of Jak-2, Tyk2, Shc, Stat3, Stat5, p120(c-cbl) and other proteins in human platelets.	Tyrosine	159-167	Cbl proto-oncogene	Homo sapiens	224-229
9209406-8	1997	Moreover, c-Cbl (pp 130) becomes tyrosine-phosphorylated rapidly and transiently depending on GM-CSF and EPO stimulation.	Tyrosine	33-41	Cbl proto-oncogene	Homo sapiens	10-15
9013636-2	1997	We show in this report that p120(cbl) (Cbl), the 120-kDa c-cbl proto-oncogene product, becomes tyrosine-phosphorylated during integrin-mediated macrophage cell adhesion to extracellular matrix substrata and anti-integrin antibodies.	Tyrosine	95-103	Cbl proto-oncogene	Homo sapiens	28-37
8995358-1	1997	We have demonstrated that a 120-kDa protein, identified as Cbl, becomes rapidly phosphorylated on tyrosine residues following stimulation of factor-dependent cells with interleukin-3 (IL-3).	Tyrosine	98-106	Cbl proto-oncogene	Homo sapiens	59-62
8995358-5	1997	Approximately 10% of the PI kinase activity present in anti-phosphotyrosine immunoprecipitates was present in anti-Cbl immunoprecipitates of IL-3-stimulated cells.	Phosphotyrosine	60-75	Cbl proto-oncogene	Homo sapiens	115-118
8995358-10	1997	The binding of the fusion proteins to Cbl occurred regardless of whether Cbl was tyrosine-phosphorylated or not, and the binding could not be disrupted by the addition of 30 mM free phosphotyrosine.	Tyrosine	81-89	Cbl proto-oncogene	Homo sapiens	38-41
8995358-10	1997	The binding of the fusion proteins to Cbl occurred regardless of whether Cbl was tyrosine-phosphorylated or not, and the binding could not be disrupted by the addition of 30 mM free phosphotyrosine.	Phosphotyrosine	182-197	Cbl proto-oncogene	Homo sapiens	38-41
9570294-5	1997	The Cbl-N region has now been shown to contain a novel phosphotyrosine-binding (PTB) domain that directly interacts with autophosphorylated tyrosine kinases via a D(N/D)XpY motif.	Phosphotyrosine	55-70	Cbl proto-oncogene	Homo sapiens	4-9
9570294-8	1997	Recent studies have also identified a novel signaling pathway initiated by the interaction of mammalian Cbl proteins with the SH2 domains of Crk adaptor molecules, which results in Cbl"s linkage with C3G, a guanine nucleotide exchange protein for Rap1 family of small G-proteins.	Guanine Nucleotides	207-225	Cbl proto-oncogene	Homo sapiens	104-107
9570294-8	1997	Recent studies have also identified a novel signaling pathway initiated by the interaction of mammalian Cbl proteins with the SH2 domains of Crk adaptor molecules, which results in Cbl"s linkage with C3G, a guanine nucleotide exchange protein for Rap1 family of small G-proteins.	Guanine Nucleotides	207-225	Cbl proto-oncogene	Homo sapiens	181-184
8989906-0	1997	Tyrosine phosphorylation of the product of the c-cbl protooncogene is [corrected] induced after integrin stimulation.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	47-52
9121472-1	1997	The human proto-oncogene product c-Cbl and a similar protein in Caenorhabditis elegans (Sli-1) contain a proline-rich COOH-terminal region that binds Src homology 3 (SH3) domains of proteins such as the adapter Grb2.	Proline	105-112	Cbl proto-oncogene	Homo sapiens	33-38
8995358-11	1997	These data suggest the unexpected conclusion that the Fyn SH2 domain may bind to Cbl in a phosphotyrosine-independent manner.	Phosphotyrosine	90-105	Cbl proto-oncogene	Homo sapiens	81-84
8995243-1	1997	T cell receptor (TCR) stimulation induces rapid tyrosine phosphorylation of cellular proteins, including Cbl, a protooncogene product whose function remains unclear.	Tyrosine	48-56	Cbl proto-oncogene	Homo sapiens	105-108
9622055-4	1997	There is high conservation between Cbl species in the amino-terminal region that contains a putative phosphotyrosine binding domain and a Ring finger motif.	Phosphotyrosine	101-116	Cbl proto-oncogene	Homo sapiens	35-38
9622055-5	1997	In the carboxy-terminal region, mammalian Cbl forms share a proline-rich stretch, conserved tyrosine residues, and a leucine zipper.	Proline	60-67	Cbl proto-oncogene	Homo sapiens	42-45
9622055-5	1997	In the carboxy-terminal region, mammalian Cbl forms share a proline-rich stretch, conserved tyrosine residues, and a leucine zipper.	Tyrosine	92-100	Cbl proto-oncogene	Homo sapiens	42-45
9622055-7	1997	Cbl is recruited to the tyrosine kinase module of these receptors and tyrosine phosphorylated after cellular activation.	Tyrosine	24-32	Cbl proto-oncogene	Homo sapiens	0-3
9013636-2	1997	We show in this report that p120(cbl) (Cbl), the 120-kDa c-cbl proto-oncogene product, becomes tyrosine-phosphorylated during integrin-mediated macrophage cell adhesion to extracellular matrix substrata and anti-integrin antibodies.	Tyrosine	95-103	Cbl proto-oncogene	Homo sapiens	39-42
9013636-2	1997	We show in this report that p120(cbl) (Cbl), the 120-kDa c-cbl proto-oncogene product, becomes tyrosine-phosphorylated during integrin-mediated macrophage cell adhesion to extracellular matrix substrata and anti-integrin antibodies.	Tyrosine	95-103	Cbl proto-oncogene	Homo sapiens	33-36
9013636-5	1997	In contrast to the rapid and transient tyrosine phosphorylation of Cbl by CSF-1 stimulation, tyrosine phosphorylation of Cbl by cell attachment was gradual and persistent.	Tyrosine	93-101	Cbl proto-oncogene	Homo sapiens	121-124
9013636-6	1997	Tyrosine-phosphorylated Cbl was found to form complexes with the SH2 domain-containing signaling proteins Src and phosphatidylinositol 3-kinase; in vitro kinase assays demonstrated that these kinases were active in the Cbl complexes following integrin ligand binding.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	24-27
9013636-6	1997	Tyrosine-phosphorylated Cbl was found to form complexes with the SH2 domain-containing signaling proteins Src and phosphatidylinositol 3-kinase; in vitro kinase assays demonstrated that these kinases were active in the Cbl complexes following integrin ligand binding.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	219-222
8900205-0	1996	Specific association of tyrosine-phosphorylated c-Cbl with Fyn tyrosine kinase in T cells.	Tyrosine	24-32	Cbl proto-oncogene	Homo sapiens	48-53
8896416-5	1996	The protein product of the c-cbl protooncogene is a 120-kD protein that is expressed in early B-lineage cells and in myeloid cells and is phosphorylated on tyrosine following receptor-mediated signaling in T and B lymphocytes.	Tyrosine	156-164	Cbl proto-oncogene	Homo sapiens	27-32
8943292-5	1996	We propose that tyrosine phosphorylation of membrane-associated Cas and Cbl creates binding sites for the Crk SH2 domain and recruits Crk complexes to cellular membranes.	Tyrosine	16-24	Cbl proto-oncogene	Homo sapiens	72-75
8950973-2	1996	In the present study we evaluated tyrosine phosphorylation of c-Cbl and the interaction of the Grb2/c-Cbl complex with signaling proteins upon activation of non-tyrosine (c-Mpl) and tyrosine kinase (c-Kit) receptors leading to myeloid cell proliferation.	Tyrosine	34-42	Cbl proto-oncogene	Homo sapiens	62-67
8950973-2	1996	In the present study we evaluated tyrosine phosphorylation of c-Cbl and the interaction of the Grb2/c-Cbl complex with signaling proteins upon activation of non-tyrosine (c-Mpl) and tyrosine kinase (c-Kit) receptors leading to myeloid cell proliferation.	Tyrosine	161-169	Cbl proto-oncogene	Homo sapiens	100-105
8950973-3	1996	By using the growth factor dependent M-07e cell line, we found that both c-Mpl and c-Kit ligands, namely: SCF and TPO, induce c-Cbl tyrosine phosphorylation.	Tyrosine	132-140	Cbl proto-oncogene	Homo sapiens	126-131
8950973-10	1996	Taken together our results demonstrate that c-Cbl plays an important role in coupling both tyrosine and non-tyrosine kinase receptors to downstream effector molecules and that different signaling molecules interact with Grb2/c-Cbl complex when non-tyrosine or tyrosine kinase receptors are activated.	Tyrosine	91-99	Cbl proto-oncogene	Homo sapiens	44-49
8941725-1	1996	We reported that ecto-NAD+ glycohydrolase activity induced upon differentiation of HL-60 cells with retinoic acid is localized on the extracellular domain of CD38 and that CD38 ligation by a specific monoclonal antibody, HB-7, is followed by rapid tyrosine phosphorylation of cellular proteins including a proto-oncogene product, Cbl.	Tretinoin	100-113	Cbl proto-oncogene	Homo sapiens	330-333
8941725-2	1996	In the present study, we investigated intracellular signaling linked to the HB-7-induced Cbl phosphorylation in dibutyryl cAMP-treated THP-1 cells.	Cyclic AMP	122-126	Cbl proto-oncogene	Homo sapiens	89-92
8941725-3	1996	The 85-kDa regulatory subunit (p85) of phosphatidylinositol (PI) 3-kinase was immunoprecipitated with anti-Cbl antibody in a manner dependent on the tyrosine phosphorylation of Cbl.	Tyrosine	149-157	Cbl proto-oncogene	Homo sapiens	107-110
8941725-3	1996	The 85-kDa regulatory subunit (p85) of phosphatidylinositol (PI) 3-kinase was immunoprecipitated with anti-Cbl antibody in a manner dependent on the tyrosine phosphorylation of Cbl.	Tyrosine	149-157	Cbl proto-oncogene	Homo sapiens	177-180
8941725-4	1996	PI 3-kinase activity was also observed in the immunoprecipitated fractions containing tyrosine-phosphorylated Cbl.	Tyrosine	86-94	Cbl proto-oncogene	Homo sapiens	110-113
8941725-6	1996	Thus, the direct association of tyrosine-phosphorylated Cbl with PI 3-kinase, possibly leading to the kinase activation, appeared to be involved in intracellular signaling caused by the CD38 ligation.	Tyrosine	32-40	Cbl proto-oncogene	Homo sapiens	56-59
8900205-8	1996	This increase is likely due to the involvement of Fyn SH2 in the interactions between Fyn and tyrosine-phosphorylated c-Cbl.	Tyrosine	94-102	Cbl proto-oncogene	Homo sapiens	118-123
8864141-4	1996	Fas receptor-induced tyrosine phosphorylation of p120 c-cbl proto-oncogene product was observed in Jurkat T cells.	Tyrosine	21-29	Cbl proto-oncogene	Homo sapiens	54-59
8695807-3	1996	In the present study, we found that CD38 ligation in the immature B-cell lines 380, REH, and RS4;11 caused rapid tyrosine phosphorylation of the protein product of the proto-oncogene c-cbl.	Tyrosine	113-121	Cbl proto-oncogene	Homo sapiens	168-188
8781445-5	1996	In addition, electron paramagnetic resonance spectroscopy of H2O-Cbl preparations showed the presence of a small amount of Cob-(II)alamin that was capable of combining with NO.	Water	61-64	Cbl proto-oncogene	Homo sapiens	65-68
8751459-0	1996	c-kit ligand stimulates tyrosine phosphorylation of the c-Cbl protein in human hematopoietic cells.	Tyrosine	24-32	Cbl proto-oncogene	Homo sapiens	56-61
8751459-4	1996	In the present studies, we demonstrate that KL stimulates the rapid tyrosine phosphorylation of the proto-oncogene, c-Cbl, in two KL-responsive human hematopoietic cell lines, MO7e and TF-1.	Tyrosine	68-76	Cbl proto-oncogene	Homo sapiens	100-121
8702998-4	1996	Previous studies from our laboratory have shown that c-Cbl is the predominant tyrosine-phosphorylated protein bound to the p85 subunit of phosphatidylinositol (PI) 3-kinase on T lymphocyte and B lymphocyte activation.	Tyrosine	78-86	Cbl proto-oncogene	Homo sapiens	53-58
8702998-4	1996	Previous studies from our laboratory have shown that c-Cbl is the predominant tyrosine-phosphorylated protein bound to the p85 subunit of phosphatidylinositol (PI) 3-kinase on T lymphocyte and B lymphocyte activation.	Phosphatidylinositols	138-158	Cbl proto-oncogene	Homo sapiens	53-58
8702998-6	1996	We show that stimulation induces the association of a highly tyrosine-phosphorylated pool of c-Cbl with lymphocyte membranes and with a detergent-insoluble particulate fraction.	Tyrosine	61-69	Cbl proto-oncogene	Homo sapiens	93-98
8702998-9	1996	Interestingly, c-Cbl tyrosine phosphorylation and the formation of c-Cbl.PI 3-kinase complexes were also observed in a mutant Jurkat cell line, JCaM1.6, lacking p56(lck) expression.	Tyrosine	21-29	Cbl proto-oncogene	Homo sapiens	15-20
8626543-9	1996	These results suggest the possibility that Cbl may participate in a signaling pathway that regulates guanine nucleotide exchange on small G-proteins in T cells.	Guanine Nucleotides	101-119	Cbl proto-oncogene	Homo sapiens	43-46
8673085-1	1996	Five folate-sensitive fragile sites have been characterized at the molecular level (FRAXA, FRAXE, FRAXF, FRA16A and FRA11B).	Folic Acid	5-11	Cbl proto-oncogene	Homo sapiens	116-122
8621483-12	1996	We show that Crk-L also participates in BCR signaling, since it inducibly interacts with tyrosine-phosphorylated Cbl.	Tyrosine	89-97	Cbl proto-oncogene	Homo sapiens	113-116
8710377-0	1996	Formation of Shc/Grb2- and Crk adaptor complexes containing tyrosine phosphorylated Cbl upon stimulation of the B-cell antigen receptor.	Tyrosine	60-68	Cbl proto-oncogene	Homo sapiens	84-87
8710377-5	1996	The 110 kDa molecule is defined as Cbl, the product of the c-cbl oncogene, which is strongly phosphorylated on tyrosine upon BCR stimulation.	Tyrosine	111-119	Cbl proto-oncogene	Homo sapiens	35-38
8710377-5	1996	The 110 kDa molecule is defined as Cbl, the product of the c-cbl oncogene, which is strongly phosphorylated on tyrosine upon BCR stimulation.	Tyrosine	111-119	Cbl proto-oncogene	Homo sapiens	59-64
8710377-10	1996	In contrast to its constitutive interaction with Grb2, tyrosine-phosphorylated Cbl only associates with Crk after BCR stimulation.	Tyrosine	55-63	Cbl proto-oncogene	Homo sapiens	79-82
8710377-12	1996	Cbl participates in all three adaptor complexes and is tyrosine phosphorylated upon BCR stimulation, pointing to a central role for this molecule in the regulation of antigen receptor-induced B cell responses.	Tyrosine	55-63	Cbl proto-oncogene	Homo sapiens	0-3
8662998-0	1996	Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	28-31
8662998-1	1996	We and others have shown that Cbl, the protein product of the c-cbl proto-oncogene, is an early target of tyrosine phosphorylation upon stimulation through the immune cell surface receptors, which signal through noncovalently associated cytoplasmic tyrosine kinases.	Tyrosine	106-114	Cbl proto-oncogene	Homo sapiens	30-33
8662998-1	1996	We and others have shown that Cbl, the protein product of the c-cbl proto-oncogene, is an early target of tyrosine phosphorylation upon stimulation through the immune cell surface receptors, which signal through noncovalently associated cytoplasmic tyrosine kinases.	Tyrosine	106-114	Cbl proto-oncogene	Homo sapiens	64-67
8662998-2	1996	Using human mammary epithelial cells that express a natural epidermal growth factor (EGF) receptor and require EGF as an essential growth factor, we demonstrate here that Cbl is a prominent target of tyrosine phosphorylation upon stimulation through the EGF receptor tyrosine kinase.	Tyrosine	200-208	Cbl proto-oncogene	Homo sapiens	171-174
8626404-2	1996	Cb1, the protein product of c-cbl proto-oncogene, has been reported to be phosphorylated on tyrosine residues upon T cell receptor (TCR) engagement.	Tyrosine	92-100	Cbl proto-oncogene	Homo sapiens	28-33
8612729-6	1996	Cross-linking of Fc gamma RII on the surface of THP-1 cells triggered (a) prominent tyrosine phosphorylation of Cbl, (b) activation of PI 3-kinase that was immunoprecipitated with the anti-Cbl or the anti-phosphotyrosine antibody, and (c) specific association of Cbl with p85.	Tyrosine	84-92	Cbl proto-oncogene	Homo sapiens	112-115
8649804-3	1996	We report that c-Cbl undergoes rapid and sustained phosphorylation on tyrosine residues upon stimulation of fibroblast and epithelial cell lines with ligands of ErbB-1.	Tyrosine	70-78	Cbl proto-oncogene	Homo sapiens	15-20
8626404-4	1996	However, in lymphocytes activated through the TCR, Cbl loses its ability to bind to Grb2 precipitated either with anti-Grb2 antibody or with an immobilized tyrosine phosphopeptide, Y1068-P, derived from the epidermal growth factor receptor.	Tyrosine	156-164	Cbl proto-oncogene	Homo sapiens	51-54
8626404-6	1996	Investigation of the time course of Cbl dissociation from Grb2 reveals that it is transient and correlates with the kinetics of tyrosine phosphorylation of Cbl.	Tyrosine	128-136	Cbl proto-oncogene	Homo sapiens	36-39
8626404-6	1996	Investigation of the time course of Cbl dissociation from Grb2 reveals that it is transient and correlates with the kinetics of tyrosine phosphorylation of Cbl.	Tyrosine	128-136	Cbl proto-oncogene	Homo sapiens	156-159
8626404-8	1996	Tyrosine-phosphorylated Cbl binds exclusively to the SH2 domain of Crk.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	24-27
8621719-1	1996	We and others have demonstrated that the c-cbl proto-oncogene product is one of the earliest targets of tyrosine phosphorylation upon T cell receptor stimulation.	Tyrosine	104-112	Cbl proto-oncogene	Homo sapiens	41-46
8621719-3	1996	We demonstrate prominent and early tyrosine phosphorylation of Cbl upon stimulation of human B cell lines through surface IgM.	Tyrosine	35-43	Cbl proto-oncogene	Homo sapiens	63-66
8621719-7	1996	Tyrosine-phosphorylated Shc, which prominently associated with Grb2, was detected in association with Cbl in activated B cells.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	102-105
8621719-8	1996	Thus, Grb2 and Shc adaptors, which associate with immunoreceptor tyrosine based activation motifs, may link Cbl to the B cell receptor.	Tyrosine	65-73	Cbl proto-oncogene	Homo sapiens	108-111
8621719-9	1996	B cell activation also induced a prominent association between Cbl and the p85 subunit of phosphatidylinositol (PI) 3-kinase resulting in the association of a substantial fraction of PI 3-kinase activity with Cbl.	Phosphatidylinositols	90-110	Cbl proto-oncogene	Homo sapiens	63-66
8621719-9	1996	B cell activation also induced a prominent association between Cbl and the p85 subunit of phosphatidylinositol (PI) 3-kinase resulting in the association of a substantial fraction of PI 3-kinase activity with Cbl.	Phosphatidylinositols	90-110	Cbl proto-oncogene	Homo sapiens	209-212
8524328-0	1996	The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner.	Tyrosine	88-96	Cbl proto-oncogene	Homo sapiens	19-22
8576149-0	1996	Tyrosine phosphorylation of the c-cbl proto-oncogene product mediated by cell surface antigen CD38 in HL-60 cells.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	32-37
8677749-6	1996	Furthermore, we have shown that the proto-oncogene c-cbl product (c-Cbl) is also tyrosine-phosphorylated by stimulation with GM-CSF or Epo and is constitutively associated with the SH3 domain of Grb2/Ash in UT-7.	Tyrosine	81-89	Cbl proto-oncogene	Homo sapiens	36-56
8677749-6	1996	Furthermore, we have shown that the proto-oncogene c-cbl product (c-Cbl) is also tyrosine-phosphorylated by stimulation with GM-CSF or Epo and is constitutively associated with the SH3 domain of Grb2/Ash in UT-7.	Tyrosine	81-89	Cbl proto-oncogene	Homo sapiens	66-71
8576149-6	1996	Moreover, one of the prominent tyrosine-phosphorylated proteins stimulated by the anti-CD38 monoclonal antibody was identified as the c-cbl proto-oncogene product, p120c-cbl.	Tyrosine	31-39	Cbl proto-oncogene	Homo sapiens	134-139
8551236-7	1996	Finally, using a heterologous system, it was demonstrated that the ability of Zap-70 to cause tyrosine phosphorylation of p120c-cbl was dependent on Lck- or FynT-mediated signals.	Tyrosine	94-102	Cbl proto-oncogene	Homo sapiens	128-131
8524328-6	1996	Instead, Crk proteins predominantly associate with the tyrosine-phosphorylated proto-oncogene product of Cbl.	Tyrosine	55-63	Cbl proto-oncogene	Homo sapiens	105-108
8524328-9	1996	The complex between c-Crk and c-Cbl is also seen upon T-cell receptor cross-linking or with the transforming, tyrosine-phosphorylated c-Cbl.	Tyrosine	110-118	Cbl proto-oncogene	Homo sapiens	30-35
8524328-9	1996	The complex between c-Crk and c-Cbl is also seen upon T-cell receptor cross-linking or with the transforming, tyrosine-phosphorylated c-Cbl.	Tyrosine	110-118	Cbl proto-oncogene	Homo sapiens	134-139
8524328-10	1996	These results indicate that Crk binds to c-Cbl in a tyrosine phosphorylation-dependent manner, suggesting a physiological role for the Crk-c-Cbl complex in Bcr-Abl tyrosine phosphorylation-mediated transformation.	Tyrosine	52-60	Cbl proto-oncogene	Homo sapiens	41-46
8524328-10	1996	These results indicate that Crk binds to c-Cbl in a tyrosine phosphorylation-dependent manner, suggesting a physiological role for the Crk-c-Cbl complex in Bcr-Abl tyrosine phosphorylation-mediated transformation.	Tyrosine	52-60	Cbl proto-oncogene	Homo sapiens	139-144
8524328-10	1996	These results indicate that Crk binds to c-Cbl in a tyrosine phosphorylation-dependent manner, suggesting a physiological role for the Crk-c-Cbl complex in Bcr-Abl tyrosine phosphorylation-mediated transformation.	Tyrosine	164-172	Cbl proto-oncogene	Homo sapiens	41-46
8524328-10	1996	These results indicate that Crk binds to c-Cbl in a tyrosine phosphorylation-dependent manner, suggesting a physiological role for the Crk-c-Cbl complex in Bcr-Abl tyrosine phosphorylation-mediated transformation.	Tyrosine	164-172	Cbl proto-oncogene	Homo sapiens	139-144
7488109-5	1995	Finally, tyrosine phosphorylation of the proto-oncogene products, Vav and c-Cbl, has been proved to be induced by TPO.	Tyrosine	9-17	Cbl proto-oncogene	Homo sapiens	74-79
7488109-0	1995	TPO/c-mpl ligand induces tyrosine phosphorylation of multiple cellular proteins including proto-oncogene products, Vav and c-Cbl, and Ras signaling molecules.	Tyrosine	25-33	Cbl proto-oncogene	Homo sapiens	123-128
7629144-10	1995	A direct association between c-cbl and p85 can be observed in vitro using a fusion protein comprising the Src homology 2 (SH2) domains of p85, and this binding is abolished by phenyl phosphate, suggesting that the interaction is mediated through phosphotyrosine-SH2 domain interactions.	phenylphosphate	176-192	Cbl proto-oncogene	Homo sapiens	29-34
8534961-1	1995	Cbl and folate are both necessary for the metabolism of HCYS, whereas only Cbl is required for MMA metabolism.	Homocysteine	56-60	Cbl proto-oncogene	Homo sapiens	0-3
8534961-1	1995	Cbl and folate are both necessary for the metabolism of HCYS, whereas only Cbl is required for MMA metabolism.	mma	95-98	Cbl proto-oncogene	Homo sapiens	75-78
8534961-5	1995	By virtue of the role of Cbl and folate in the metabolic pathways that involve MMA and HCYS, levels of both metabolites rise in Cbl deficiency, but only HCYS rises in folate deficiency.	mma	79-82	Cbl proto-oncogene	Homo sapiens	25-28
8534961-5	1995	By virtue of the role of Cbl and folate in the metabolic pathways that involve MMA and HCYS, levels of both metabolites rise in Cbl deficiency, but only HCYS rises in folate deficiency.	Homocysteine	87-91	Cbl proto-oncogene	Homo sapiens	25-28
8534961-5	1995	By virtue of the role of Cbl and folate in the metabolic pathways that involve MMA and HCYS, levels of both metabolites rise in Cbl deficiency, but only HCYS rises in folate deficiency.	Homocysteine	153-157	Cbl proto-oncogene	Homo sapiens	25-28
8534961-13	1995	Finally, the measurement of serum levels of MMA, HCYS and other metabolites that accumulate in Cbl and folate deficiencies may provide important new insights into the mechanism whereby these vitamin deficiencies lead to different patterns and manifestations of disease.	mma	44-47	Cbl proto-oncogene	Homo sapiens	95-98
8534961-13	1995	Finally, the measurement of serum levels of MMA, HCYS and other metabolites that accumulate in Cbl and folate deficiencies may provide important new insights into the mechanism whereby these vitamin deficiencies lead to different patterns and manifestations of disease.	Homocysteine	49-53	Cbl proto-oncogene	Homo sapiens	95-98
8534966-6	1995	Because N2O inactivates Cbl, abuse of the gas may lead to typical Cbl neuropathy.	Nitrous Oxide	8-11	Cbl proto-oncogene	Homo sapiens	24-27
8534966-6	1995	Because N2O inactivates Cbl, abuse of the gas may lead to typical Cbl neuropathy.	Nitrous Oxide	8-11	Cbl proto-oncogene	Homo sapiens	66-69
7652556-3	1995	SLI-1 and c-Cbl share approximately 55 percent amino acid identity over a stretch of 390 residues, which includes a C3HC4 zinc-binding motif known as the RING finger, and multiple consensus binding sites for Src homology 3 (SH3) domains.	c3hc4	116-121	Cbl proto-oncogene	Homo sapiens	10-15
7592693-2	1995	Cross-linking of CD3 and CD4 receptors in Jurkat T cells causes tyrosine phosphorylation of Cbl and its association with phosphatidylinositol 3"-kinase (Meisner, H., Conway, B., Hartley, D., and Czech, M. P. (1995) Mol.	Tyrosine	64-72	Cbl proto-oncogene	Homo sapiens	92-95
7592693-6	1995	Here we demonstrate that Cbl is also present in nonlymphoid cells, and that epidermal growth factor (EGF) elicits its rapid tyrosine phosphorylation in human embryonic 293 cells.	Tyrosine	124-132	Cbl proto-oncogene	Homo sapiens	25-28
7592693-9	1995	Both Grb2 and EGF receptors are released from Cbl in the presence of a proline-rich peptide that binds the NH2-terminal SH3 domain of Grb2.	Proline	71-78	Cbl proto-oncogene	Homo sapiens	46-49
7592693-10	1995	These results indicate that autophosphorylated EGF receptors associate with the SH2 domain of Grb2, which is complexed through its SH3 domain with proline-rich regions of Cbl.	Proline	147-154	Cbl proto-oncogene	Homo sapiens	171-174
7592693-11	1995	Such recruitment of Cbl to EGF receptors may reflect an important mechanism for its tyrosine phosphorylation and for assembling signaling components that mediate or modulate EGF actions.	Tyrosine	84-92	Cbl proto-oncogene	Homo sapiens	20-23
8534960-4	1995	Over the last few years, it has been demonstrated that Cbl bound to Hc in the stomach is only transferred to IF after the action of pancreatic trypsin.	Hydrocortisone	68-70	Cbl proto-oncogene	Homo sapiens	55-58
8534960-5	1995	It is also possible that Hc-bound biliary Cbl is transferred to IF in this way and that the Cbl in the Cbl-IF complex is absorbed in the terminal ileum, thus constituting an enterohepatic cycle.	Hydrocortisone	25-27	Cbl proto-oncogene	Homo sapiens	42-45
7629144-10	1995	A direct association between c-cbl and p85 can be observed in vitro using a fusion protein comprising the Src homology 2 (SH2) domains of p85, and this binding is abolished by phenyl phosphate, suggesting that the interaction is mediated through phosphotyrosine-SH2 domain interactions.	Phosphotyrosine	246-261	Cbl proto-oncogene	Homo sapiens	29-34
7791764-2	1995	One of the most rapidly tyrosine-phosphorylated polypeptides is the 120-kDa product of the proto-oncogene c-cbl, a cytosolic and cytoskeletal protein containing multiple proline-rich motifs that are potential binding sites for proteins containing Src homology 3 (SH3) domains.	Tyrosine	24-32	Cbl proto-oncogene	Homo sapiens	108-111
7782294-0	1995	Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	50-55
7782294-2	1995	We identified one of the most prominent tyrosine-phosphorylated proteins in Fc gamma receptor (Fc gamma R)-stimulated macrophages to be c-Cbl.	Tyrosine	40-48	Cbl proto-oncogene	Homo sapiens	136-141
7782294-3	1995	Tyrosine phosphorylation of c-Cbl occurred within 20 s after stimulation and reached maximum levels within 3-5 min.	Tyrosine	0-8	Cbl proto-oncogene	Homo sapiens	28-33
7782294-4	1995	c-Cbl was also tyrosine-phosphorylated in epidermal growth factor (EGF) receptor-overexpressing cells upon EGF stimulation, in macrophages in response to CSF-1 treatment, and in v-src transformed cells.	Tyrosine	15-23	Cbl proto-oncogene	Homo sapiens	0-5
7791764-2	1995	One of the most rapidly tyrosine-phosphorylated polypeptides is the 120-kDa product of the proto-oncogene c-cbl, a cytosolic and cytoskeletal protein containing multiple proline-rich motifs that are potential binding sites for proteins containing Src homology 3 (SH3) domains.	Proline	170-177	Cbl proto-oncogene	Homo sapiens	108-111
7791764-5	1995	Grb2 antisera also precipitated p85 from serum-starved cells, while TCR activation increased p85 and tyrosine-phosphorylated Cbl but not Cbl protein in Grb2 immunocomplexes.	Tyrosine	101-109	Cbl proto-oncogene	Homo sapiens	125-128
7791764-6	1995	Phosphatidylinositol (PI) 3-kinase activity was immunoprecipitated from serum-starved cells with Cbl and to a lesser extent with Grb2 antisera, and TCR cross-linking increased this activity severalfold.	Phosphatidylinositols	0-20	Cbl proto-oncogene	Homo sapiens	97-100
7566367-8	1995	However, carnitine acetyltransferase activity of AD CBL (n = 7) was significantly lower than that of control CBL (n = 6) (1.33 +/- 0.88 versus 2.26 +/- 0.66 nmol/min/mg protein; p = 0.05).	Carnitine	9-18	Cbl proto-oncogene	Homo sapiens	52-55
7771463-14	1995	Methyl-THF also neutralized MTX in pernicious anemia, but its effect was certainly enhanced by addition of CN-Cbl.	5-Methyl THF	0-10	Cbl proto-oncogene	Homo sapiens	110-113
7537740-0	1995	The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells.	Tyrosine	41-49	Cbl proto-oncogene	Homo sapiens	27-32
7742531-1	1995	Transcobalamin II (TCII) is a plasma protein that binds vitamin B12 (cobalamin; Cbl) and facilitates the cellular uptake of the vitamin by receptor-mediated endocytosis.	Vitamin B 12	56-67	Cbl proto-oncogene	Homo sapiens	80-83
7537740-11	1995	Moreover, c-Cbl (pp130) becomes tyrosine phosphorylated rapidly and transiently depending on GM-CSF or Epo stimulation.	Tyrosine	32-40	Cbl proto-oncogene	Homo sapiens	10-15
7537740-11	1995	Moreover, c-Cbl (pp130) becomes tyrosine phosphorylated rapidly and transiently depending on GM-CSF or Epo stimulation.	pp130	17-22	Cbl proto-oncogene	Homo sapiens	10-15
7881408-2	1994	However, one case report has highlighted a possible relationship between the inheritance of a rare folate-sensitive fragile site in band 11q23.3 (FRA11B) and the chromosome 11q23--&gt;qter deletion in Jacobsen (11q-) syndrome.	Folic Acid	99-105	Cbl proto-oncogene	Homo sapiens	146-152
7757233-4	1995	The purified Cbl-IF complex was coupled to epoxy-Sepharose with a yield of 23.8% and a specific activity of 1.2 nmol per mol of gel.	epoxy-sepharose	43-58	Cbl proto-oncogene	Homo sapiens	13-16
7881408-6	1994	FISH experiments with YACs and cosmids from this region have localised FRA11B to an interval of approximately 100 kb containing the 5" end of the CBL2 gene, which includes a CCG trinucleotide repeat.	trinucleotide	178-191	Cbl proto-oncogene	Homo sapiens	71-77
7881408-6	1994	FISH experiments with YACs and cosmids from this region have localised FRA11B to an interval of approximately 100 kb containing the 5" end of the CBL2 gene, which includes a CCG trinucleotide repeat.	trinucleotide	178-191	Cbl proto-oncogene	Homo sapiens	146-150
7858712-1	1994	The previously reported ability of SP-Sephadex C25 column chromatography for partitioning biologically important cobalamins has been modified to include analytical separation of nitritocobalamin (NO2-Cbl) and nitrosocobalamin (NO-Cbl).	nitritocobalamin	178-194	Cbl proto-oncogene	Homo sapiens	200-203
8083187-0	1994	The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor.	Tyrosine	62-70	Cbl proto-oncogene	Homo sapiens	27-32
7923922-2	1994	Histamine inhibited Ig production by the human B cell lines IM-9 and CBL in a dose-dependent fashion during 4 days of culture.	Histamine	0-9	Cbl proto-oncogene	Homo sapiens	69-72
8126135-2	1994	GH enhanced the production of Ig by and thymidine uptake of the human lymphoblastoid B cell lines, CBL and GM-1056.	Thymidine	40-49	Cbl proto-oncogene	Homo sapiens	99-102
8034639-6	1994	Following uptake, internalized IF is degraded with a half-time of 4 h. Leupeptin causes a partial block in the proteolysis of IF, an intracellular accumulation of Cbl bound to IF, and a decrease in transcytosis of Cbl.	leupeptin	71-80	Cbl proto-oncogene	Homo sapiens	163-166
8034639-6	1994	Following uptake, internalized IF is degraded with a half-time of 4 h. Leupeptin causes a partial block in the proteolysis of IF, an intracellular accumulation of Cbl bound to IF, and a decrease in transcytosis of Cbl.	leupeptin	71-80	Cbl proto-oncogene	Homo sapiens	214-217
7901104-3	1993	The latter requires CH3-Cbl and catalyzes the conversion of 5-CH3-tetrahydrofolate and homocysteine to tetrahydrofolate and methionine, respectively.	Methionine	124-134	Cbl proto-oncogene	Homo sapiens	24-27
8311452-1	1994	A specific receptor on the plasma membrane of mammalian cells facilitates the uptake of vitamin B12 (cobalamin, Cbl) by receptor-mediated endocytosis of transcobalamin II-bound Cbl (TCII-Cbl).	Vitamin B 12	88-99	Cbl proto-oncogene	Homo sapiens	112-115
8311452-1	1994	A specific receptor on the plasma membrane of mammalian cells facilitates the uptake of vitamin B12 (cobalamin, Cbl) by receptor-mediated endocytosis of transcobalamin II-bound Cbl (TCII-Cbl).	Vitamin B 12	88-99	Cbl proto-oncogene	Homo sapiens	177-180
8311452-1	1994	A specific receptor on the plasma membrane of mammalian cells facilitates the uptake of vitamin B12 (cobalamin, Cbl) by receptor-mediated endocytosis of transcobalamin II-bound Cbl (TCII-Cbl).	Vitamin B 12	88-99	Cbl proto-oncogene	Homo sapiens	177-180
7901104-2	1993	The former requires adenosyl-Cbl and catalyzes the conversion of L-methylmalonyl-CoA to succinyl-CoA.	(R)-methylmalonyl-CoA	65-84	Cbl proto-oncogene	Homo sapiens	29-32
8311452-7	1994	The unstable TCII-Cbl binding in the soluble fraction was protected by the addition of 15% glycerol to the preparation and storage at -20 degrees C. The apparent M(r) of the receptor estimated by SDS-PAGE of the crosslinked receptor 125I-TCII-Cbl is approximately 58,000.	Glycerol	91-99	Cbl proto-oncogene	Homo sapiens	18-21
8311452-7	1994	The unstable TCII-Cbl binding in the soluble fraction was protected by the addition of 15% glycerol to the preparation and storage at -20 degrees C. The apparent M(r) of the receptor estimated by SDS-PAGE of the crosslinked receptor 125I-TCII-Cbl is approximately 58,000.	Sodium Dodecyl Sulfate	196-199	Cbl proto-oncogene	Homo sapiens	18-21
7694037-1	1993	Homocysteine and 5-CH3-tetrahydrofolate (5-CH3-THF) are converted to methionine and THF by the CH3-cobalamin (CH3-Cbl)-dependent enzyme methionine synthase.	5-ch3-tetrahydrofolate	17-39	Cbl proto-oncogene	Homo sapiens	114-117
7901104-2	1993	The former requires adenosyl-Cbl and catalyzes the conversion of L-methylmalonyl-CoA to succinyl-CoA.	succinyl-coenzyme A	88-100	Cbl proto-oncogene	Homo sapiens	29-32
7901104-3	1993	The latter requires CH3-Cbl and catalyzes the conversion of 5-CH3-tetrahydrofolate and homocysteine to tetrahydrofolate and methionine, respectively.	5-ch3-tetrahydrofolate	60-82	Cbl proto-oncogene	Homo sapiens	24-27
7901104-3	1993	The latter requires CH3-Cbl and catalyzes the conversion of 5-CH3-tetrahydrofolate and homocysteine to tetrahydrofolate and methionine, respectively.	Homocysteine	87-99	Cbl proto-oncogene	Homo sapiens	24-27
7901104-3	1993	The latter requires CH3-Cbl and catalyzes the conversion of 5-CH3-tetrahydrofolate and homocysteine to tetrahydrofolate and methionine, respectively.	5,6,7,8-tetrahydrofolic acid	66-82	Cbl proto-oncogene	Homo sapiens	24-27
7694037-1	1993	Homocysteine and 5-CH3-tetrahydrofolate (5-CH3-THF) are converted to methionine and THF by the CH3-cobalamin (CH3-Cbl)-dependent enzyme methionine synthase.	5-ch3-thf	41-50	Cbl proto-oncogene	Homo sapiens	114-117
7694037-1	1993	Homocysteine and 5-CH3-tetrahydrofolate (5-CH3-THF) are converted to methionine and THF by the CH3-cobalamin (CH3-Cbl)-dependent enzyme methionine synthase.	Methionine	69-79	Cbl proto-oncogene	Homo sapiens	114-117
7694037-1	1993	Homocysteine and 5-CH3-tetrahydrofolate (5-CH3-THF) are converted to methionine and THF by the CH3-cobalamin (CH3-Cbl)-dependent enzyme methionine synthase.	tetrahydrofuran	47-50	Cbl proto-oncogene	Homo sapiens	114-117
7694037-2	1993	Serum homocysteine levels are elevated in more than 95% of patients with Cbl or folate deficiency and in patients with inborn errors involving the synthesis of 5-CH3-THF or CH3-Cbl.	Homocysteine	6-18	Cbl proto-oncogene	Homo sapiens	73-76
7694037-2	1993	Serum homocysteine levels are elevated in more than 95% of patients with Cbl or folate deficiency and in patients with inborn errors involving the synthesis of 5-CH3-THF or CH3-Cbl.	Homocysteine	6-18	Cbl proto-oncogene	Homo sapiens	177-180
7694037-11	1993	In patients with cbl C and cbl D mutations, methionine levels remained low or low-normal at 8.3 to 15.6 mumol/L (normal, 13.3 to 42.7) despite betaine treatment.	Methionine	44-54	Cbl proto-oncogene	Homo sapiens	17-20
7694037-11	1993	In patients with cbl C and cbl D mutations, methionine levels remained low or low-normal at 8.3 to 15.6 mumol/L (normal, 13.3 to 42.7) despite betaine treatment.	Methionine	44-54	Cbl proto-oncogene	Homo sapiens	27-30
7694037-11	1993	In patients with cbl C and cbl D mutations, methionine levels remained low or low-normal at 8.3 to 15.6 mumol/L (normal, 13.3 to 42.7) despite betaine treatment.	Betaine	143-150	Cbl proto-oncogene	Homo sapiens	17-20
7694037-12	1993	We conclude that (1) betaine levels are maintained in most patients with Cbl and folate deficiency; (2) levels of N,N-dimethylglycine and N-methylglycine are increased in most patients with folate deficiency; and (3) betaine therapy is relatively ineffective in patients with defective synthesis of CH3-Cbl.	Betaine	21-28	Cbl proto-oncogene	Homo sapiens	73-76
1565471-7	1992	This results in the translation of a 72 kDa protein, compared with the 120 kDa protein encoded by full-length c-cbl, which lacks a portion of the proline-rich domain and the entire leucine zipper.	Proline	146-153	Cbl proto-oncogene	Homo sapiens	110-115
8439564-9	1993	This translation product was immunoprecipitated with rabbit anti-serum to human TC II and was able to bind to Cbl-Sepharose beads.	Sepharose	114-123	Cbl proto-oncogene	Homo sapiens	110-113
1516297-1	1992	Several of the inborn errors of vitamin B12 (cobalamin, Cbl) metabolism (cblC, cblD, cblE, cblF, cblG) are associated with homocystinuria and hypomethioninemia due to a functional deficiency of the cytoplasmic enzyme methionine synthase which requires methylcobalamin (MeCbl) as a cofactor.	Vitamin B 12	32-43	Cbl proto-oncogene	Homo sapiens	56-59
1516297-1	1992	Several of the inborn errors of vitamin B12 (cobalamin, Cbl) metabolism (cblC, cblD, cblE, cblF, cblG) are associated with homocystinuria and hypomethioninemia due to a functional deficiency of the cytoplasmic enzyme methionine synthase which requires methylcobalamin (MeCbl) as a cofactor.	mecobalamin	252-267	Cbl proto-oncogene	Homo sapiens	56-59
1516297-1	1992	Several of the inborn errors of vitamin B12 (cobalamin, Cbl) metabolism (cblC, cblD, cblE, cblF, cblG) are associated with homocystinuria and hypomethioninemia due to a functional deficiency of the cytoplasmic enzyme methionine synthase which requires methylcobalamin (MeCbl) as a cofactor.	mecobalamin	269-274	Cbl proto-oncogene	Homo sapiens	56-59
1744096-2	1991	Methylcobalamin (Me-Cbl) is tightly bound to methionine synthase and is required for enzymatic activity.	mecobalamin	0-15	Cbl proto-oncogene	Homo sapiens	20-23
1744096-3	1991	When added to crude tissue homogenates, Me-Cbl stimulates methionine synthase but similar stimulation is observed with hydroxocobalamin, cyanocobalamin (CN-Cbl), and adenosyl-Cbl, although the mechanisms involved are unknown.	Vitamin B 12	137-151	Cbl proto-oncogene	Homo sapiens	43-46
1744096-7	1991	Studies with 14 different Cbl analogues with alterations in various portions of the corrin ring and the nucleotide showed that all of the analogues were able to fully activate human methionine synthase when they were reduced with 2-mercaptoethanol.	corrin	84-90	Cbl proto-oncogene	Homo sapiens	26-29
1744096-7	1991	Studies with 14 different Cbl analogues with alterations in various portions of the corrin ring and the nucleotide showed that all of the analogues were able to fully activate human methionine synthase when they were reduced with 2-mercaptoethanol.	Mercaptoethanol	230-247	Cbl proto-oncogene	Homo sapiens	26-29
1687159-3	1991	One was classified as a Cbl A variant and was responsive to hydroxocobalamin therapy in vitro and in vivo.	Hydroxocobalamin	60-76	Cbl proto-oncogene	Homo sapiens	24-27
1649019-2	1991	Epo enhanced IgM production and thymidine uptake by a human IgM-producing lymphoblastoid cell line, CBL.	Thymidine	32-41	Cbl proto-oncogene	Homo sapiens	100-103
2003608-8	1991	Under these conditions, [57Co]Cbl complexed to haptocorrin was not transported.	Cobalt-57	25-29	Cbl proto-oncogene	Homo sapiens	30-33
1904400-8	1991	DSCG also enhanced IgG2 and IgM production from human B-cell lines GM-1500 and CBL, respectively.	Cromolyn Sodium	0-4	Cbl proto-oncogene	Homo sapiens	79-82
2003608-10	1991	The [57Co]Cbl transcytosed using either IF[57Co]Cbl or free [57Co]Cbl as ligands was bound exclusively to TC II.	Cobalt-57	5-9	Cbl proto-oncogene	Homo sapiens	10-13
2003608-10	1991	The [57Co]Cbl transcytosed using either IF[57Co]Cbl or free [57Co]Cbl as ligands was bound exclusively to TC II.	Cobalt-57	5-9	Cbl proto-oncogene	Homo sapiens	48-51
2003608-10	1991	The [57Co]Cbl transcytosed using either IF[57Co]Cbl or free [57Co]Cbl as ligands was bound exclusively to TC II.	Cobalt-57	5-9	Cbl proto-oncogene	Homo sapiens	48-51
2003608-11	1991	Intracellular [57Co]Cbl decreased during transcytosis with a slow (t1/2 = 4 h) transfer of [57Co]Cbl from IF to TC II.	Cobalt-57	15-19	Cbl proto-oncogene	Homo sapiens	20-23
2003608-11	1991	Intracellular [57Co]Cbl decreased during transcytosis with a slow (t1/2 = 4 h) transfer of [57Co]Cbl from IF to TC II.	Cobalt-57	15-19	Cbl proto-oncogene	Homo sapiens	97-100
34921583-3	2022	Herein, the authors propose a chemical buffer layer coated on Zn metal (CBL@Zn) anode, in which ZnO nanorods are uniformly dispersed in graphene oxide (GO), to improve the reversibility of Zn ZnO electrochemical conversion process.	zn zno	189-195	Cbl proto-oncogene	Homo sapiens	72-75
34921583-5	2022	Therefore, the symmetrical CBL@Zn-CBL@Zn coin cell achieves a superior stability of 100 cycles with quite low overpotential (30 mv).	Zinc	38-40	Cbl proto-oncogene	Homo sapiens	27-30
34921583-5	2022	Therefore, the symmetrical CBL@Zn-CBL@Zn coin cell achieves a superior stability of 100 cycles with quite low overpotential (30 mv).	Zinc	38-40	Cbl proto-oncogene	Homo sapiens	34-37
34157521-4	2021	Integrin-induced activation of EGFR and subsequent tyrosine phosphorylation of a class of acceptor sites on EGFR leads to alignment and tyrosine phosphorylation of Shc, PLCgamma, the p85 subunit of PI-3 K, and Cbl, followed by activation of the downstream targets Erk and Akt/PKB.	Tyrosine	51-59	Cbl proto-oncogene	Homo sapiens	210-213
34157521-4	2021	Integrin-induced activation of EGFR and subsequent tyrosine phosphorylation of a class of acceptor sites on EGFR leads to alignment and tyrosine phosphorylation of Shc, PLCgamma, the p85 subunit of PI-3 K, and Cbl, followed by activation of the downstream targets Erk and Akt/PKB.	Tyrosine	136-144	Cbl proto-oncogene	Homo sapiens	210-213
2368803-2	1990	Urinary organic acid assays established a probable diagnosis of Cbl-C-type methylmalonic aciduria, later confirmed by complementation studies.	organic acid	8-20	Cbl proto-oncogene	Homo sapiens	64-67
34413458-4	2022	In participants without prevalent myeloid neoplasms, eGFR.cys was associated with myeloid mCA (n = 148, beta = -3.36, P = 0.01) and somatic driver mutations (n = 3241, beta = -1.08, P = 6.25 x 10-5) associated with myeloid neoplasia (myeloid CH), specifically mutations in CBL, TET2, JAK2, PPM1D and GNB1 but not DNMT3A or ASXL1.	Cysteine	58-61	Cbl proto-oncogene	Homo sapiens	273-276
34921583-3	2022	Herein, the authors propose a chemical buffer layer coated on Zn metal (CBL@Zn) anode, in which ZnO nanorods are uniformly dispersed in graphene oxide (GO), to improve the reversibility of Zn ZnO electrochemical conversion process.	zn metal	62-70	Cbl proto-oncogene	Homo sapiens	72-75
34921583-3	2022	Herein, the authors propose a chemical buffer layer coated on Zn metal (CBL@Zn) anode, in which ZnO nanorods are uniformly dispersed in graphene oxide (GO), to improve the reversibility of Zn ZnO electrochemical conversion process.	Zinc	76-78	Cbl proto-oncogene	Homo sapiens	72-75
34921583-3	2022	Herein, the authors propose a chemical buffer layer coated on Zn metal (CBL@Zn) anode, in which ZnO nanorods are uniformly dispersed in graphene oxide (GO), to improve the reversibility of Zn ZnO electrochemical conversion process.	Zinc Oxide	96-99	Cbl proto-oncogene	Homo sapiens	72-75
34921583-3	2022	Herein, the authors propose a chemical buffer layer coated on Zn metal (CBL@Zn) anode, in which ZnO nanorods are uniformly dispersed in graphene oxide (GO), to improve the reversibility of Zn ZnO electrochemical conversion process.	graphene oxide	136-150	Cbl proto-oncogene	Homo sapiens	72-75
34921583-3	2022	Herein, the authors propose a chemical buffer layer coated on Zn metal (CBL@Zn) anode, in which ZnO nanorods are uniformly dispersed in graphene oxide (GO), to improve the reversibility of Zn ZnO electrochemical conversion process.	graphene oxide	152-154	Cbl proto-oncogene	Homo sapiens	72-75
34775495-9	2022	miR-155-5p was found to target CBL to inhibit CBL expression.	mir-155-5p	0-10	Cbl proto-oncogene	Homo sapiens	31-34
34775495-9	2022	miR-155-5p was found to target CBL to inhibit CBL expression.	mir-155-5p	0-10	Cbl proto-oncogene	Homo sapiens	46-49
34775495-10	2022	miR-155-5p promoted the proliferation of ALL cells and inhibited their apoptosis by inhibiting the expression of CBL, which otherwise degraded IRF4 protein through ubiquitination, leading to inhibited CDK6 expression.	mir-155-5p	0-10	Cbl proto-oncogene	Homo sapiens	113-116