PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 34116361-9 2021 More importantly,AGEs-induced up-regulation of PXDN and 3-Cl-Tyr with endothelial dysfunction were transformed by NOX2 silencing and H2O2 scavengers. Hydrogen Peroxide 133-137 peroxidasin Mus musculus 47-51 24895407-3 2014 Here, we describe the first Pxdn mouse mutant which was induced by ENU (N-ethyl-N-nitrosourea) and led to a recessive phenotype. Ethylnitrosourea 72-93 peroxidasin Mus musculus 28-32 18929642-7 2008 A molecular model of the VPO1 peroxidase region reveals a structure very similar to that of known peroxidases, including a conserved heme binding cavity, critical catalytic residues, and a calcium binding site. Heme 133-137 peroxidasin Mus musculus 25-29 18929642-7 2008 A molecular model of the VPO1 peroxidase region reveals a structure very similar to that of known peroxidases, including a conserved heme binding cavity, critical catalytic residues, and a calcium binding site. Calcium 189-196 peroxidasin Mus musculus 25-29 18929642-8 2008 The absorbance spectra of VPO1 are similar to those of lactoperoxidase, and covalent attachment of the heme to VPO1 protein was demonstrated by chemiluminescent heme staining. Heme 103-107 peroxidasin Mus musculus 26-30 18929642-8 2008 The absorbance spectra of VPO1 are similar to those of lactoperoxidase, and covalent attachment of the heme to VPO1 protein was demonstrated by chemiluminescent heme staining. Heme 103-107 peroxidasin Mus musculus 111-115 18929642-8 2008 The absorbance spectra of VPO1 are similar to those of lactoperoxidase, and covalent attachment of the heme to VPO1 protein was demonstrated by chemiluminescent heme staining. Heme 161-165 peroxidasin Mus musculus 111-115 18929642-9 2008 VPO1 purified from heart or expressed in HEK cells is catalytically active, with a K(m) for H(2)O(2) of 1.5 mM. Hydrogen Peroxide 92-100 peroxidasin Mus musculus 0-4 18929642-10 2008 When co-expressed in cells, VPO1 can use H(2)O(2) produced by NADPH oxidase enzymes. Hydrogen Peroxide 41-49 peroxidasin Mus musculus 28-32 34116361-2 2021 Peroxidasin (PXDN, VPO1) is one member of peroxidases family that catalyzes hydrogen peroxide (H2O2) to hypochlorous acid (HOCl). Hydrogen Peroxide 76-93 peroxidasin Mus musculus 0-11 34116361-2 2021 Peroxidasin (PXDN, VPO1) is one member of peroxidases family that catalyzes hydrogen peroxide (H2O2) to hypochlorous acid (HOCl). Hydrogen Peroxide 76-93 peroxidasin Mus musculus 13-17 34116361-2 2021 Peroxidasin (PXDN, VPO1) is one member of peroxidases family that catalyzes hydrogen peroxide (H2O2) to hypochlorous acid (HOCl). Hydrogen Peroxide 76-93 peroxidasin Mus musculus 19-23 34116361-2 2021 Peroxidasin (PXDN, VPO1) is one member of peroxidases family that catalyzes hydrogen peroxide (H2O2) to hypochlorous acid (HOCl). Hydrogen Peroxide 95-99 peroxidasin Mus musculus 0-11 34116361-2 2021 Peroxidasin (PXDN, VPO1) is one member of peroxidases family that catalyzes hydrogen peroxide (H2O2) to hypochlorous acid (HOCl). Hydrogen Peroxide 95-99 peroxidasin Mus musculus 13-17 34116361-10 2021 Thus, these results support the conclusion that PXDN promotes AGEs-induced diabetic vascular endothelial dysfunction by attenuating eNOS phosphorylation at Ser1177 via NOX2/HOCl/Akt pathway. Hypochlorous Acid 173-177 peroxidasin Mus musculus 48-52 34116361-2 2021 Peroxidasin (PXDN, VPO1) is one member of peroxidases family that catalyzes hydrogen peroxide (H2O2) to hypochlorous acid (HOCl). Hydrogen Peroxide 95-99 peroxidasin Mus musculus 19-23 34116361-2 2021 Peroxidasin (PXDN, VPO1) is one member of peroxidases family that catalyzes hydrogen peroxide (H2O2) to hypochlorous acid (HOCl). Hypochlorous Acid 104-121 peroxidasin Mus musculus 0-11 34116361-2 2021 Peroxidasin (PXDN, VPO1) is one member of peroxidases family that catalyzes hydrogen peroxide (H2O2) to hypochlorous acid (HOCl). Hypochlorous Acid 104-121 peroxidasin Mus musculus 13-17 35437145-4 2022 The adsorbed PXDN exerts abnormally high activity to crosslink Col IV via increasing the formation of sulfilimine bonds at the NC1 domain, leading to an overly dense matrix in the lung tissue. sulfilimine 102-113 peroxidasin Mus musculus 13-17 34116361-2 2021 Peroxidasin (PXDN, VPO1) is one member of peroxidases family that catalyzes hydrogen peroxide (H2O2) to hypochlorous acid (HOCl). Hypochlorous Acid 104-121 peroxidasin Mus musculus 19-23 34116361-2 2021 Peroxidasin (PXDN, VPO1) is one member of peroxidases family that catalyzes hydrogen peroxide (H2O2) to hypochlorous acid (HOCl). Hypochlorous Acid 123-127 peroxidasin Mus musculus 0-11 34116361-2 2021 Peroxidasin (PXDN, VPO1) is one member of peroxidases family that catalyzes hydrogen peroxide (H2O2) to hypochlorous acid (HOCl). Hypochlorous Acid 123-127 peroxidasin Mus musculus 13-17 34116361-2 2021 Peroxidasin (PXDN, VPO1) is one member of peroxidases family that catalyzes hydrogen peroxide (H2O2) to hypochlorous acid (HOCl). Hypochlorous Acid 123-127 peroxidasin Mus musculus 19-23 35093588-3 2022 Here, we studied the expression and function of Peroxidasin (PXDN), a peroxidase that uses H2O2 to cross-link collagen IV, during liver fibrosis progression and regression. Hydrogen Peroxide 91-95 peroxidasin Mus musculus 48-59 35093588-3 2022 Here, we studied the expression and function of Peroxidasin (PXDN), a peroxidase that uses H2O2 to cross-link collagen IV, during liver fibrosis progression and regression. Hydrogen Peroxide 91-95 peroxidasin Mus musculus 61-65 35093588-12 2022 Elevated ROS in Pxdn-/- livers was observed, which can result in activation of hypoxic signaling cascades and may affect signaling pathways involved in macrophage polarization such as TNF-alpha via NF-kappaB. ros 9-12 peroxidasin Mus musculus 16-20 32675287-4 2020 The level of 3-bromotyrosine in extracellular matrix proteins from normally cultured cells was 1.1 mmol/mol tyrosine and decreased significantly in the presence of the peroxidasin inhibitor, phloroglucinol. 3-bromotyrosine 13-28 peroxidasin Mus musculus 168-179 32675287-4 2020 The level of 3-bromotyrosine in extracellular matrix proteins from normally cultured cells was 1.1 mmol/mol tyrosine and decreased significantly in the presence of the peroxidasin inhibitor, phloroglucinol. Tyrosine 20-28 peroxidasin Mus musculus 168-179 32675287-4 2020 The level of 3-bromotyrosine in extracellular matrix proteins from normally cultured cells was 1.1 mmol/mol tyrosine and decreased significantly in the presence of the peroxidasin inhibitor, phloroglucinol. Phloroglucinol 191-205 peroxidasin Mus musculus 168-179 32675287-5 2020 A negligible amount of 3-bromotyrosine was detected in peroxidasin-knockout cells. 3-bromotyrosine 23-38 peroxidasin Mus musculus 55-66 32675287-6 2020 3-Bromotyrosine formed both during cell growth in culture and in the isolated decellularized extracellular matrix when embedded peroxidasin was supplied with hydrogen peroxide and bromide. 3-bromotyrosine 0-15 peroxidasin Mus musculus 128-139 32675287-6 2020 3-Bromotyrosine formed both during cell growth in culture and in the isolated decellularized extracellular matrix when embedded peroxidasin was supplied with hydrogen peroxide and bromide. Hydrogen Peroxide 158-175 peroxidasin Mus musculus 128-139 32675287-6 2020 3-Bromotyrosine formed both during cell growth in culture and in the isolated decellularized extracellular matrix when embedded peroxidasin was supplied with hydrogen peroxide and bromide. Bromides 180-187 peroxidasin Mus musculus 128-139 32675287-10 2020 Our findings provide evidence that peroxidasin promotes the formation of 3-bromotyrosine in proteins. 3-bromotyrosine 73-88 peroxidasin Mus musculus 35-46 32675287-11 2020 They show that HOBr produced by peroxidasin is selective for, but not limited to, the crosslinking of collagen IV. hypobromous acid 15-19 peroxidasin Mus musculus 32-43 32675287-12 2020 Based on our findings, the use of 3-bromotyrosine as a specific biomarker of oxidative damage by HOBr warrants further investigation in clinical conditions linked to high peroxidasin expression. 3-bromotyrosine 34-49 peroxidasin Mus musculus 171-182 32675287-12 2020 Based on our findings, the use of 3-bromotyrosine as a specific biomarker of oxidative damage by HOBr warrants further investigation in clinical conditions linked to high peroxidasin expression. hypobromous acid 97-101 peroxidasin Mus musculus 171-182 32571911-8 2020 In peroxidasin knockout mice, bromine enrichment of basement membranes of kidneys was reduced by ~85%. Bromine 30-37 peroxidasin Mus musculus 3-14 32571911-10 2020 Bromination of tyrosine-1485 was reduced by >90% in kidneys of peroxidasin knockout mice. Tyrosine 15-23 peroxidasin Mus musculus 63-74 32571911-11 2020 Thus, in addition to promoting sulfilimine cross-links in collagen IV, peroxidasin can also brominate a bystander tyrosine. Tyrosine 114-122 peroxidasin Mus musculus 71-82 30565999-3 2019 The animal heme peroxidases myeloperoxidase (MPO), eosinophil peroxidase (EPX), and peroxidasin (PXDN) uniquely metabolize H2O2 into highly reactive and destructive hypohalous acids, such as hypobromous and hypochlorous acid. Hydrogen Peroxide 123-127 peroxidasin Mus musculus 84-95 30565999-3 2019 The animal heme peroxidases myeloperoxidase (MPO), eosinophil peroxidase (EPX), and peroxidasin (PXDN) uniquely metabolize H2O2 into highly reactive and destructive hypohalous acids, such as hypobromous and hypochlorous acid. Hydrogen Peroxide 123-127 peroxidasin Mus musculus 97-101 30565999-3 2019 The animal heme peroxidases myeloperoxidase (MPO), eosinophil peroxidase (EPX), and peroxidasin (PXDN) uniquely metabolize H2O2 into highly reactive and destructive hypohalous acids, such as hypobromous and hypochlorous acid. hypohalous acids 165-181 peroxidasin Mus musculus 84-95 30565999-3 2019 The animal heme peroxidases myeloperoxidase (MPO), eosinophil peroxidase (EPX), and peroxidasin (PXDN) uniquely metabolize H2O2 into highly reactive and destructive hypohalous acids, such as hypobromous and hypochlorous acid. hypohalous acids 165-181 peroxidasin Mus musculus 97-101 32675287-0 2020 Peroxidasin mediates bromination of tyrosine residues in the extracellular matrix. Tyrosine 36-44 peroxidasin Mus musculus 0-11 32675287-1 2020 Peroxidasin is a heme peroxidase that oxidizes bromide to hypobromous acid (HOBr), a powerful oxidant that promotes the formation of the sulfilimine crosslink in collagen IV in basement membranes. Bromides 47-54 peroxidasin Mus musculus 0-11 32675287-1 2020 Peroxidasin is a heme peroxidase that oxidizes bromide to hypobromous acid (HOBr), a powerful oxidant that promotes the formation of the sulfilimine crosslink in collagen IV in basement membranes. hypobromous acid 58-74 peroxidasin Mus musculus 0-11 32675287-1 2020 Peroxidasin is a heme peroxidase that oxidizes bromide to hypobromous acid (HOBr), a powerful oxidant that promotes the formation of the sulfilimine crosslink in collagen IV in basement membranes. hypobromous acid 76-80 peroxidasin Mus musculus 0-11 32675287-1 2020 Peroxidasin is a heme peroxidase that oxidizes bromide to hypobromous acid (HOBr), a powerful oxidant that promotes the formation of the sulfilimine crosslink in collagen IV in basement membranes. sulfilimine 137-148 peroxidasin Mus musculus 0-11 32675287-2 2020 We investigated whether HOBr released by peroxidasin leads to other oxidative modifications of proteins, particularly bromination of tyrosine residues, in peroxidasin-expressing PFHR9 cells. hypobromous acid 24-28 peroxidasin Mus musculus 41-52 32675287-2 2020 We investigated whether HOBr released by peroxidasin leads to other oxidative modifications of proteins, particularly bromination of tyrosine residues, in peroxidasin-expressing PFHR9 cells. hypobromous acid 24-28 peroxidasin Mus musculus 155-166 31817535-1 2019 Peroxidasin (PXDN) is a unique peroxidase containing extracellular matrix motifs and stabilizes collagen IV networks by forming sulfilimine crosslinks. sulfilimine 128-139 peroxidasin Mus musculus 0-11 31817535-1 2019 Peroxidasin (PXDN) is a unique peroxidase containing extracellular matrix motifs and stabilizes collagen IV networks by forming sulfilimine crosslinks. sulfilimine 128-139 peroxidasin Mus musculus 13-17 30844643-2 2019 VPO1 is a heme enzyme that uses hydrogen peroxide (H2O2) to produce hypochlorous acid (HOCl). Hydrogen Peroxide 32-49 peroxidasin Mus musculus 0-4 30844643-2 2019 VPO1 is a heme enzyme that uses hydrogen peroxide (H2O2) to produce hypochlorous acid (HOCl). Hydrogen Peroxide 51-55 peroxidasin Mus musculus 0-4 30844643-2 2019 VPO1 is a heme enzyme that uses hydrogen peroxide (H2O2) to produce hypochlorous acid (HOCl). Hypochlorous Acid 68-85 peroxidasin Mus musculus 0-4 30844643-2 2019 VPO1 is a heme enzyme that uses hydrogen peroxide (H2O2) to produce hypochlorous acid (HOCl). Hypochlorous Acid 87-91 peroxidasin Mus musculus 0-4 30844643-8 2019 Mechanistically, the fibrotic effects following MI of VPO1 manifested partially through HOCl formation to activate Smad2/3 and ERK1/2. Hypochlorous Acid 88-92 peroxidasin Mus musculus 54-58 30844643-9 2019 Thus, we conclude that VPO1 is a crucial regulator of cardiac fibrosis after MI by mediating HOCl/Smad2/3 and ERK1/2 signaling pathways, implying a promising therapeutic target in ischemic cardiomyopathy. Hypochlorous Acid 93-97 peroxidasin Mus musculus 23-27 28424209-6 2017 A sulfilimine bond (S = N) between a methionine sulfur and a lysine nitrogen cross-links collagen IV and is formed by the matrix enzyme peroxidasin. sulfilimine 2-13 peroxidasin Mus musculus 136-147 28424209-6 2017 A sulfilimine bond (S = N) between a methionine sulfur and a lysine nitrogen cross-links collagen IV and is formed by the matrix enzyme peroxidasin. methionine sulfur 37-54 peroxidasin Mus musculus 136-147 28424209-6 2017 A sulfilimine bond (S = N) between a methionine sulfur and a lysine nitrogen cross-links collagen IV and is formed by the matrix enzyme peroxidasin. lysine nitrogen 61-76 peroxidasin Mus musculus 136-147 28424209-7 2017 In peroxidasin knockout mice with reduced collagen IV sulfilimine cross-links, we find a reduction in renal tubular BM stiffness. sulfilimine 54-65 peroxidasin Mus musculus 3-14