PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
32645138-11	2020	Hematoxylin-eosin staining, immunohistochemistry, and TUNEL assays confirmed that miR-28-5p antagomir inhibited cell growth and accelerated apoptosis.	Hematoxylin	0-11	microRNA 28	Homo sapiens	82-88
32765698-9	2020	Before and after treatment, miR-28-3p was significantly positively correlated with ADL score and Hcy level, but negatively correlated with MMSE score and MoCA score.	Homocysteine	97-100	microRNA 28	Homo sapiens	28-34
32765698-11	2020	Donepezil therapy may reduce miR-28-3p level to alleviate the symptoms of AD patients, and miR-28-3p level can be used as an early diagnosis and prognosis evaluation of AD patients.	Donepezil	0-9	microRNA 28	Homo sapiens	29-35
32645138-11	2020	Hematoxylin-eosin staining, immunohistochemistry, and TUNEL assays confirmed that miR-28-5p antagomir inhibited cell growth and accelerated apoptosis.	Eosine Yellowish-(YS)	12-17	microRNA 28	Homo sapiens	82-88
32028704-7	2020	We validated miR-28-5p/SREBF2 interaction, demonstrating that SREBF2 inhibition affects almost all the tumor processes altered by miR-28-5p re-expression, suggesting that SREBF2 is an important mediator of miR-28-5p TS activity.	-5p	19-22	microRNA 28	Homo sapiens	130-136
32721183-0	2020	MiR-28-5p mediates the anti-proliferative and pro-apoptotic effects of curcumin on human diffuse large B-cell lymphoma cells.	Curcumin	71-79	microRNA 28	Homo sapiens	0-6
32721183-7	2020	RESULTS: Curcumin decreased the viability of OCI-LY7 cells in a concentration- and time-dependent manner, and these effects were attenuated by miR-28-5p inhibition.	Curcumin	9-17	microRNA 28	Homo sapiens	143-149
32721183-8	2020	MiR-28-5p expression was upregulated by curcumin.	Curcumin	40-48	microRNA 28	Homo sapiens	0-6
32721183-9	2020	Curcumin increased the numbers of apoptotic cells and upregulated cleaved caspase-3 expression, and these effects were attenuated by miR-28-5p inhibition.	Curcumin	0-8	microRNA 28	Homo sapiens	133-139
32721183-12	2020	CONCLUSIONS: Our results described the curcumin exerted anti-proliferative and pro-apoptotic effects on OCI-LY7 cells through a mechanism potentially involving miR-28-5p.	Curcumin	39-47	microRNA 28	Homo sapiens	160-166
32151690-0	2020	CircCBFB-mediated miR-28-5p facilitates abdominal aortic aneurysm via LYPD3 and GRIA4.	circcbfb	0-8	microRNA 28	Homo sapiens	18-24
32151690-12	2020	Moreover, circCBFB served as a sponge of miR-28-5p, releasing GRIA4 and LYPD3 from miR-28-5p suppression.	circcbfb	10-18	microRNA 28	Homo sapiens	41-47
32151690-13	2020	Functionally, GRIA4, LYPD3 and miR-28-5p were required in circCBFB-mediated VSMC apoptosis.	circcbfb	58-66	microRNA 28	Homo sapiens	31-37
32006897-4	2020	Si-LOXL1-AS1 and miR-28-5p inhibitor were transfected to downregulate the expressions of LOXL1-AS1 and miR-28-5p, while miR-28-5p mimics were used to upregulate the miR-28-5p expression.	Silicon	0-2	microRNA 28	Homo sapiens	103-109
32006897-4	2020	Si-LOXL1-AS1 and miR-28-5p inhibitor were transfected to downregulate the expressions of LOXL1-AS1 and miR-28-5p, while miR-28-5p mimics were used to upregulate the miR-28-5p expression.	Silicon	0-2	microRNA 28	Homo sapiens	103-109
32006897-4	2020	Si-LOXL1-AS1 and miR-28-5p inhibitor were transfected to downregulate the expressions of LOXL1-AS1 and miR-28-5p, while miR-28-5p mimics were used to upregulate the miR-28-5p expression.	Silicon	0-2	microRNA 28	Homo sapiens	103-109
32028704-7	2020	We validated miR-28-5p/SREBF2 interaction, demonstrating that SREBF2 inhibition affects almost all the tumor processes altered by miR-28-5p re-expression, suggesting that SREBF2 is an important mediator of miR-28-5p TS activity.	-5p	19-22	microRNA 28	Homo sapiens	130-136
31607309-7	2019	The miR-28-5p target CCND1 was expressed at high levels in MM patients with LPP / miR-28-5p methylation, the expression level of miR-28-5p in MM patients correlated with beta2-MG concentration.	CHEMBL3740941	11-13	microRNA 28	Homo sapiens	4-10
31707339-0	2020	Lung-derived exosomes in phosgene-induced acute lung injury regulate the functions of mesenchymal stem cells partially via miR-28-5p.	Phosgene	25-33	microRNA 28	Homo sapiens	123-129
31885628-5	2019	The correlation between miR-28-5p expression and sorafenib benefits in HCC was further evaluated in patient-derived xenografts (PDXs).	sorafenib	49-58	microRNA 28	Homo sapiens	24-30
31885628-11	2019	Furthermore, the miR-28-5p knockdown HCC cells were more sensitive to sorafenib treatment.	sorafenib	70-79	microRNA 28	Homo sapiens	17-23
31885628-12	2019	Analysis of patient-derived xenografts (PDXs) further demonstrated that the miR-28-5p may predict sorafenib benefits in HCC patients.	sorafenib	98-107	microRNA 28	Homo sapiens	76-82
31885628-13	2019	Conclusion: Our findings revealed the crucial role of the miR-28-5p in liver CSC expansion and sorafenib response, rendering miR-28-5p an optimal therapeutic target for HCC.	sorafenib	95-104	microRNA 28	Homo sapiens	58-64
31885628-13	2019	Conclusion: Our findings revealed the crucial role of the miR-28-5p in liver CSC expansion and sorafenib response, rendering miR-28-5p an optimal therapeutic target for HCC.	sorafenib	95-104	microRNA 28	Homo sapiens	125-131
31607309-7	2019	The miR-28-5p target CCND1 was expressed at high levels in MM patients with LPP / miR-28-5p methylation, the expression level of miR-28-5p in MM patients correlated with beta2-MG concentration.	CHEMBL3740941	11-13	microRNA 28	Homo sapiens	82-88
31607309-7	2019	The miR-28-5p target CCND1 was expressed at high levels in MM patients with LPP / miR-28-5p methylation, the expression level of miR-28-5p in MM patients correlated with beta2-MG concentration.	CHEMBL3740941	11-13	microRNA 28	Homo sapiens	82-88
30455104-9	2019	Besides, a doubling in titanium was associated with a separate 53.4% and 47.2% decreased miR-24-3p and miR-28-5p expression in normal lung tissues.	Titanium	23-31	microRNA 28	Homo sapiens	103-109
28775176-5	2018	RESULTS: LPP/miR-28 was completely unmethylated in all healthy controls and 12 (80%) HMCLs, but partially methylated in three (20%) HMCLs.	hmcls	85-90	microRNA 28	Homo sapiens	13-19
30249101-11	2018	Among the five miRNAs, the overexpression of hsa-miR-28-5p and hsa-miR-125a-5p had significant correlation to imatinib resistance or imatinib sensitivity in GIST patients.	Imatinib Mesylate	110-118	microRNA 28	Homo sapiens	45-55
30249101-11	2018	Among the five miRNAs, the overexpression of hsa-miR-28-5p and hsa-miR-125a-5p had significant correlation to imatinib resistance or imatinib sensitivity in GIST patients.	Imatinib Mesylate	133-141	microRNA 28	Homo sapiens	45-55
30249101-12	2018	Hsa-miR-28-5p and hsa-miR-125a-5p may be involved in the development and progression of GIST, and they may be able to serve as prognostic markers for imatinib-response in GIST patients.	Imatinib Mesylate	150-158	microRNA 28	Homo sapiens	0-10
28775176-6	2018	Methylation of LPP/miR-28 correlated with low expression of miR-285p (p=0.012) and LPP (p=0.037) in HMCLs.	hmcls	100-105	microRNA 28	Homo sapiens	19-25
28775176-7	2018	In RPMI-8226R cells, in which LPP/miR-28 was partially methylated, 5-AzadC treatment led to demethylation of LPP/miR-28 and re-expression of both miR-28-5p (p=0.0007) and LPP (p=0.0007), whereas continuous culture without 5-AzadC restored LPP/miR-28 methylation and reduced expression of both miR-28-5p (p=0.0013) and LPP (p=0.0025).	Decitabine	67-74	microRNA 28	Homo sapiens	34-40
28775176-7	2018	In RPMI-8226R cells, in which LPP/miR-28 was partially methylated, 5-AzadC treatment led to demethylation of LPP/miR-28 and re-expression of both miR-28-5p (p=0.0007) and LPP (p=0.0007), whereas continuous culture without 5-AzadC restored LPP/miR-28 methylation and reduced expression of both miR-28-5p (p=0.0013) and LPP (p=0.0025).	Decitabine	67-74	microRNA 28	Homo sapiens	113-119
28775176-7	2018	In RPMI-8226R cells, in which LPP/miR-28 was partially methylated, 5-AzadC treatment led to demethylation of LPP/miR-28 and re-expression of both miR-28-5p (p=0.0007) and LPP (p=0.0007), whereas continuous culture without 5-AzadC restored LPP/miR-28 methylation and reduced expression of both miR-28-5p (p=0.0013) and LPP (p=0.0025).	Decitabine	67-74	microRNA 28	Homo sapiens	113-119
28775176-7	2018	In RPMI-8226R cells, in which LPP/miR-28 was partially methylated, 5-AzadC treatment led to demethylation of LPP/miR-28 and re-expression of both miR-28-5p (p=0.0007) and LPP (p=0.0007), whereas continuous culture without 5-AzadC restored LPP/miR-28 methylation and reduced expression of both miR-28-5p (p=0.0013) and LPP (p=0.0025).	Decitabine	67-74	microRNA 28	Homo sapiens	113-119
28775176-7	2018	In RPMI-8226R cells, in which LPP/miR-28 was partially methylated, 5-AzadC treatment led to demethylation of LPP/miR-28 and re-expression of both miR-28-5p (p=0.0007) and LPP (p=0.0007), whereas continuous culture without 5-AzadC restored LPP/miR-28 methylation and reduced expression of both miR-28-5p (p=0.0013) and LPP (p=0.0025).	Decitabine	67-74	microRNA 28	Homo sapiens	113-119
28775176-8	2018	Moreover, a known miR-28-5p target, CCND1, was expressed at higher levels in HMCLs with LPP/miR-28 methylation than those without, consistent with a tumour suppressor role of miR-28-5p in myeloma.	hmcls	77-82	microRNA 28	Homo sapiens	18-24
28775176-8	2018	Moreover, a known miR-28-5p target, CCND1, was expressed at higher levels in HMCLs with LPP/miR-28 methylation than those without, consistent with a tumour suppressor role of miR-28-5p in myeloma.	hmcls	77-82	microRNA 28	Homo sapiens	92-98
28775176-8	2018	Moreover, a known miR-28-5p target, CCND1, was expressed at higher levels in HMCLs with LPP/miR-28 methylation than those without, consistent with a tumour suppressor role of miR-28-5p in myeloma.	hmcls	77-82	microRNA 28	Homo sapiens	92-98
25568327-9	2015	Interestingly, genetic studies on the transmission of the virus has shown that the ATK-1 strain, which carries a Thr-to-Cys transition mutation, is transmitted efficiently between spouses, suggesting that miR-28 may play an important role in HTLV-1 transmission.	Threonine	113-116	microRNA 28	Homo sapiens	205-211
28350078-4	2017	We established that miR-28-5p promoted the progression of ovarian cancer cell proliferation using colony forming assay and MTT assay.	monooxyethylene trimethylolpropane tristearate	123-126	microRNA 28	Homo sapiens	20-26
27338735-4	2016	We show that miR-28 was upregulated in cardiomyocytes treated with hydrogen peroxide (H2O2).	Hydrogen Peroxide	67-84	microRNA 28	Homo sapiens	13-19
27338735-4	2016	We show that miR-28 was upregulated in cardiomyocytes treated with hydrogen peroxide (H2O2).	Hydrogen Peroxide	86-90	microRNA 28	Homo sapiens	13-19
27338735-5	2016	MiR-28 gain of function sensitized cell apoptosis, whereas miR-28 loss of function partially rescued cell apoptosis induced by H2O2.	Hydrogen Peroxide	127-131	microRNA 28	Homo sapiens	59-65
26754294-8	2016	Moreover, we found that TAMs induced by miR-28-5p-IL-34 signaling inhibit miR-28-5p expression on HCC cells by transforming growth factor beta 1, resulting in an miR-28-5p-IL-34-macrophage-positive feedback loop.	Tamoxifen	24-28	microRNA 28	Homo sapiens	40-46
26754294-8	2016	Moreover, we found that TAMs induced by miR-28-5p-IL-34 signaling inhibit miR-28-5p expression on HCC cells by transforming growth factor beta 1, resulting in an miR-28-5p-IL-34-macrophage-positive feedback loop.	Tamoxifen	24-28	microRNA 28	Homo sapiens	74-80
26754294-8	2016	Moreover, we found that TAMs induced by miR-28-5p-IL-34 signaling inhibit miR-28-5p expression on HCC cells by transforming growth factor beta 1, resulting in an miR-28-5p-IL-34-macrophage-positive feedback loop.	Tamoxifen	24-28	microRNA 28	Homo sapiens	74-80
26702486-11	2016	KEGG pathway analysis showed that miR-28-3p might involve in PE related pathways such as inositol phosphate metabolism and phosphatidylinositol signaling system.	Inositol Phosphates	89-107	microRNA 28	Homo sapiens	34-40
26702486-11	2016	KEGG pathway analysis showed that miR-28-3p might involve in PE related pathways such as inositol phosphate metabolism and phosphatidylinositol signaling system.	Phosphatidylinositols	123-143	microRNA 28	Homo sapiens	34-40
26258540-8	2015	Specifically, miR-28, miR-26, and let-7b previously shown to inhibit sex steroid production in human granulosa cells, were up-regulated.	Steroids	73-80	microRNA 28	Homo sapiens	14-20
25568327-9	2015	Interestingly, genetic studies on the transmission of the virus has shown that the ATK-1 strain, which carries a Thr-to-Cys transition mutation, is transmitted efficiently between spouses, suggesting that miR-28 may play an important role in HTLV-1 transmission.	Cysteine	120-123	microRNA 28	Homo sapiens	205-211
24556689-9	2014	High glucose coupled with oxidative stress resulted in upregulation of miR28-5p, which directly inhibited expression of the p53 deacetylase sirtuin 3, resulting in increased levels of acetylated p53.	Glucose	5-12	microRNA 28	Homo sapiens	71-76
24633190-9	2014	In the validation analysis, urinary 4-hydroxyphenanthrene and/or plasma BPDE-Alb adducts were associated with lower miR-24-3p, miR-27a-3p, miR-142-5p, and miR-28-5p expression (p < 0.030).	4-hydroxyphenanthrene	36-57	microRNA 28	Homo sapiens	155-161
23934683-5	2013	Twelve miRNA showed altered expression after Se depletion: miR-625, miR-492, miR-373*, miR-22, miR-532-5p, miR-106b, miR-30b, miR-185, miR-203, miR1308, miR-28-5p, miR-10b.	Selenium	45-47	microRNA 28	Homo sapiens	153-159
24434277-8	2014	We also discovered that methamphetamine up-regulated the cellular anti-HIV-1 microRNAs (miR-125b, miR-150, and miR-28-5p) in CD4(+) T cells.	Methamphetamine	24-39	microRNA 28	Homo sapiens	111-117
34758885-7	2021	In addition, METH down-regulated the expression of the HIV restriction microRNAs (miR-28, miR-29a, miR-125b, miR-146a, miR-155, miR-223, and miR-382).	Methamphetamine	13-17	microRNA 28	Homo sapiens	82-88
34094909-7	2021	Therefore, we hypothesize LINC02381 might act by decreasing the levels of miR-96-5p and miR-28-3p, promoting the MODY activation in cervical ADC.	linc02381	26-35	microRNA 28	Homo sapiens	88-94
34402004-6	2021	A total of 11 differentially expressed PAH-responsive miRNAs were observed each in two or more cell-based studies (miR-181a and miR-30c-1), animal model studies (miR-291a and miR-292), and human population-based studies (miR-126, miR-142-5p, miR-150-5p, miR-24-3p, miR-27a-3p, miR-28-5p, and miR-320b).	Polycyclic Aromatic Hydrocarbons	39-42	microRNA 28	Homo sapiens	277-283