PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
31533472-9	2019	Moreover, emetine significantly reduced the protein levels of RhoA (Ras homolog gene family, member A), Rho-kinases (ROCK1 and ROCK2 [rho-associated coiled-coil containing protein kinases 1 and 2]), and their downstream CyPA (cyclophilin A), and Bsg (basigin) in PAH-PASMCs.	Emetine	10-17	basigin (Ok blood group)	Homo sapiens	251-258
30953513-5	2019	In vitro, tunicamycin treatment and genetic tools were used to produce non-glycosylated and lowly glycosylated CD147.	Tunicamycin	10-21	basigin (Ok blood group)	Homo sapiens	111-116
31681766-0	2019	Doxycycline Inducible Chimeric Antigen Receptor T Cells Targeting CD147 for Hepatocellular Carcinoma Therapy.	Doxycycline	0-11	basigin (Ok blood group)	Homo sapiens	66-71
31681766-7	2019	Proliferation, cytotoxicity, and cytokine secretion of Tet-CD147CART cells were significantly increased against CD147-positive cancer cells in the presence of doxycycline (Dox) compared to Tet-CD147CART cells in the absence of Dox and PBMCs.	Doxycycline	159-170	basigin (Ok blood group)	Homo sapiens	59-64
31681766-7	2019	Proliferation, cytotoxicity, and cytokine secretion of Tet-CD147CART cells were significantly increased against CD147-positive cancer cells in the presence of doxycycline (Dox) compared to Tet-CD147CART cells in the absence of Dox and PBMCs.	Doxycycline	172-175	basigin (Ok blood group)	Homo sapiens	59-64
31681766-7	2019	Proliferation, cytotoxicity, and cytokine secretion of Tet-CD147CART cells were significantly increased against CD147-positive cancer cells in the presence of doxycycline (Dox) compared to Tet-CD147CART cells in the absence of Dox and PBMCs.	Doxycycline	227-230	basigin (Ok blood group)	Homo sapiens	59-64
31681766-9	2019	Taken together, our results indicated that the expression and activity of CD147CAR were controlled by Dox both in vitro and in vivo, which facilitated decreased toxicity and adverse effects to CAR-T cell therapy.	Doxycycline	102-105	basigin (Ok blood group)	Homo sapiens	74-79
31215640-4	2019	Here, we demonstrated that CD147 undergoes an intramembranous cleavage by the gamma-secretase at lysine 231 to release its intracellular domains (ICDs).	Lysine	97-103	basigin (Ok blood group)	Homo sapiens	27-32
31600731-3	2020	Basigin is also a chaperone protein for specific metabolite transporters in the plasma cell membrane such as the monocarboxylate transporters and is an important regulator of cell metabolism.	dimethoxy biphenyl monocarboxylate	113-128	basigin (Ok blood group)	Homo sapiens	0-7
31497203-4	2019	METHODS: The mRNA expression of BSG in LUAD was from GEO, Oncomine and TCGA database.	oncomine	58-66	basigin (Ok blood group)	Homo sapiens	32-35
31312365-1	2019	We have previously demonstrated that anti-CD44s H4C4 or liposomal-delivered STAT3 inhibitor FLLL32 sensitized pancreatic cancer cells to radiotherapy through the elimination or inhibition of cancer stem cells (CSCs) and that HAb18G/CD147 promoted STAT3-mediated pancreatic tumor development by forming a signaling complex with CD44s.	FLLL 32	92-98	basigin (Ok blood group)	Homo sapiens	232-237
31016558-8	2019	RESULTS: We identified phosphorylated serine-246 in the C terminus of CD147 in primary HCC tissues, whereas serine to alanine substitution mutation analysis suggested that CD147 is phosphorylated mainly at serine-252 in HCC-derived Huh-7 cells.	Serine	38-44	basigin (Ok blood group)	Homo sapiens	70-75
31016558-8	2019	RESULTS: We identified phosphorylated serine-246 in the C terminus of CD147 in primary HCC tissues, whereas serine to alanine substitution mutation analysis suggested that CD147 is phosphorylated mainly at serine-252 in HCC-derived Huh-7 cells.	Serine	108-114	basigin (Ok blood group)	Homo sapiens	172-177
31016558-8	2019	RESULTS: We identified phosphorylated serine-246 in the C terminus of CD147 in primary HCC tissues, whereas serine to alanine substitution mutation analysis suggested that CD147 is phosphorylated mainly at serine-252 in HCC-derived Huh-7 cells.	Alanine	118-125	basigin (Ok blood group)	Homo sapiens	172-177
31016558-8	2019	RESULTS: We identified phosphorylated serine-246 in the C terminus of CD147 in primary HCC tissues, whereas serine to alanine substitution mutation analysis suggested that CD147 is phosphorylated mainly at serine-252 in HCC-derived Huh-7 cells.	Serine	108-114	basigin (Ok blood group)	Homo sapiens	172-177
30699066-8	2019	Nevertheless, treatment with short-chain fatty acids (SCFAs) increased the expression of MCT4 and CD147 as well as the sensitivity of HCT-15 cells to 3BP.	Fatty Acids, Volatile	29-52	basigin (Ok blood group)	Homo sapiens	98-103
30942433-6	2019	Additionally, an increased expression level of CD147 suppressed the elevated production of reactive oxygen species and mitochondrial membrane potential levels induced by shikonin.	Reactive Oxygen Species	91-114	basigin (Ok blood group)	Homo sapiens	47-52
30942433-7	2019	The data indicated that shikonin-induced apoptosis in glioma cells was associated with the downregulation of CD147 and the upregulation of oxidative stress.	shikonin	24-32	basigin (Ok blood group)	Homo sapiens	109-114
30771155-0	2019	Resveratrol Abrogates Hypoxia-Induced Up-Regulation of Exosomal Amyloid-beta Partially by Inhibiting CD147.	Resveratrol	0-11	basigin (Ok blood group)	Homo sapiens	101-106
30771155-2	2019	Resveratrol (RSV) has been proved to be neuroprotective in AD models, and down-regulated the expression of CD147, an additional subunit of gamma-secretase.	Resveratrol	0-11	basigin (Ok blood group)	Homo sapiens	107-112
30771155-2	2019	Resveratrol (RSV) has been proved to be neuroprotective in AD models, and down-regulated the expression of CD147, an additional subunit of gamma-secretase.	Resveratrol	13-16	basigin (Ok blood group)	Homo sapiens	107-112
30771155-9	2019	Treatment with RSV abrogated these changes in Abeta expression, inhibited the hypoxia-induced down-regulation of SIRT1 and up-regulation of CD147.	Resveratrol	15-18	basigin (Ok blood group)	Homo sapiens	140-145
30771155-12	2019	Furthermore, overexpressing CD147 in cells exposed to hypoxia facilitated the production of Abeta1-40 and Abeta1-42, while application of RSV reduced the CD147 expression as well as Abeta levels in both exosomes and exosome-free CM.	Resveratrol	138-141	basigin (Ok blood group)	Homo sapiens	154-159
30771155-13	2019	These results suggested that RSV abrogated hypoxia-induced up-regulation of total and exosomal Abeta partially by inhibiting CD147.	Resveratrol	29-32	basigin (Ok blood group)	Homo sapiens	125-130
29788898-15	2019	Lenalidomide decreases also basigin and monocarboxylate transporter 1 in MM cells.	Lenalidomide	0-12	basigin (Ok blood group)	Homo sapiens	28-35
30320488-0	2019	CD147-mediated glucose metabolic regulation contributes to the predictive role of 18 F-FDG PET/CT imaging for EGFR-TKI treatment sensitivity in NSCLC.	Glucose	15-22	basigin (Ok blood group)	Homo sapiens	0-5
30320488-1	2019	The aim of this study is to investigate the role of CD147 in glucose metabolic regulation and its association with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment sensitivity prediction using 18 F-fluorodeoxyglucose (18 F-FDG) PET/CT imaging in non-small cell lung cancer (NSCLC).	Glucose	61-68	basigin (Ok blood group)	Homo sapiens	52-57
30320488-1	2019	The aim of this study is to investigate the role of CD147 in glucose metabolic regulation and its association with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment sensitivity prediction using 18 F-fluorodeoxyglucose (18 F-FDG) PET/CT imaging in non-small cell lung cancer (NSCLC).	Fluorodeoxyglucose F18	230-249	basigin (Ok blood group)	Homo sapiens	52-57
30320488-1	2019	The aim of this study is to investigate the role of CD147 in glucose metabolic regulation and its association with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment sensitivity prediction using 18 F-fluorodeoxyglucose (18 F-FDG) PET/CT imaging in non-small cell lung cancer (NSCLC).	f-fdg	254-259	basigin (Ok blood group)	Homo sapiens	52-57
30320488-8	2019	EGFR-TKI treatment sensitivity prediction in NSCLC using 18 F-FDG PET/CT imaging significantly correlated with CD147-mediated glucose metabolic regulation via the Akt/mTOR-dependent pathway.	Glucose	126-133	basigin (Ok blood group)	Homo sapiens	111-116
30446621-7	2019	In human CD147, binding of CAIV was mediated by the negatively charged Glu-73 and in rat CD147 by the positively charged Lys-73.	Lysine	121-124	basigin (Ok blood group)	Homo sapiens	89-94
30467201-0	2019	The small-molecule compound AC-73 targeting CD147 inhibits leukemic cell proliferation, induces autophagy and increases the chemotherapeutic sensitivity of acute myeloid leukemia cells.	AC-73	28-33	basigin (Ok blood group)	Homo sapiens	44-49
30467201-11	2019	Altogether, our study indicates CD147 as a novel potential target in the treatment of AML and AC-73 as an anti-proliferative drug and an inducer of autophagy in leukemic cells to use in combination with chemotherapeutic agents.	AC-73	94-99	basigin (Ok blood group)	Homo sapiens	32-37
30727993-8	2019	In the in vitro experiment, CD147 and MUC5AC expression levels were significantly increased after CS extract incubation compared with those after no treatment.	Cesium	98-100	basigin (Ok blood group)	Homo sapiens	28-33
30727993-9	2019	Silencing CD147 by siRNA decreased the CS extract-induced MUC5AC secretion and MMP9 and phosphorylated p38 MAPK production.	Cesium	39-41	basigin (Ok blood group)	Homo sapiens	10-15
30727993-12	2019	Increased CD147 levels induced by CS extract could stimulate MUC5AC secretion through the MMP9 and p38 MAPK signaling pathway in HBE cells.	Cesium	34-36	basigin (Ok blood group)	Homo sapiens	10-15
29788898-16	2019	MM cells with low expression of Ikaros, Aiolos and basigin are more sensitive to lenalidomide treatment.	Lenalidomide	81-93	basigin (Ok blood group)	Homo sapiens	51-58
30403475-4	2018	Then CD147-MTRN/DOX was formed with MTRN/DOX and monoclonal antibody that specifically binds to CD147 protein.	mtrn	11-15	basigin (Ok blood group)	Homo sapiens	5-10
30403475-4	2018	Then CD147-MTRN/DOX was formed with MTRN/DOX and monoclonal antibody that specifically binds to CD147 protein.	mtrn	11-15	basigin (Ok blood group)	Homo sapiens	96-101
30403475-4	2018	Then CD147-MTRN/DOX was formed with MTRN/DOX and monoclonal antibody that specifically binds to CD147 protein.	Doxorubicin	16-19	basigin (Ok blood group)	Homo sapiens	5-10
30403475-4	2018	Then CD147-MTRN/DOX was formed with MTRN/DOX and monoclonal antibody that specifically binds to CD147 protein.	Doxorubicin	16-19	basigin (Ok blood group)	Homo sapiens	96-101
30403475-4	2018	Then CD147-MTRN/DOX was formed with MTRN/DOX and monoclonal antibody that specifically binds to CD147 protein.	mtrn	36-40	basigin (Ok blood group)	Homo sapiens	5-10
30403475-4	2018	Then CD147-MTRN/DOX was formed with MTRN/DOX and monoclonal antibody that specifically binds to CD147 protein.	mtrn	36-40	basigin (Ok blood group)	Homo sapiens	96-101
30403475-4	2018	Then CD147-MTRN/DOX was formed with MTRN/DOX and monoclonal antibody that specifically binds to CD147 protein.	Doxorubicin	41-44	basigin (Ok blood group)	Homo sapiens	5-10
30403475-7	2018	Hence, CD147-MTRN/DOX could enhance the responsiveness of hepatoma cells to the pre-existing chemotherapy drugs owing to active targeting combined synergistically with thermotherapy and chemotherapy, which has more significant anticancer effects than MTRN/DOX.	mtrn	13-17	basigin (Ok blood group)	Homo sapiens	7-12
30403475-7	2018	Hence, CD147-MTRN/DOX could enhance the responsiveness of hepatoma cells to the pre-existing chemotherapy drugs owing to active targeting combined synergistically with thermotherapy and chemotherapy, which has more significant anticancer effects than MTRN/DOX.	Doxorubicin	18-21	basigin (Ok blood group)	Homo sapiens	7-12
30403475-7	2018	Hence, CD147-MTRN/DOX could enhance the responsiveness of hepatoma cells to the pre-existing chemotherapy drugs owing to active targeting combined synergistically with thermotherapy and chemotherapy, which has more significant anticancer effects than MTRN/DOX.	mtrn	251-255	basigin (Ok blood group)	Homo sapiens	7-12
30403475-7	2018	Hence, CD147-MTRN/DOX could enhance the responsiveness of hepatoma cells to the pre-existing chemotherapy drugs owing to active targeting combined synergistically with thermotherapy and chemotherapy, which has more significant anticancer effects than MTRN/DOX.	Doxorubicin	256-259	basigin (Ok blood group)	Homo sapiens	7-12
30186567-1	2018	Objectives: The study aimed to uncover the underlying mechanism linking wear particles to osteoclast differentiation, and we explored the effect of titanium particles of different sizes on CD147 expression and autophagy in macrophages.	Titanium	148-156	basigin (Ok blood group)	Homo sapiens	189-194
30463017-7	2018	Basigin release mediated by TMPRSS11B enhances lactate export and glycolytic metabolism, thereby promoting tumorigenesis.	Lactic Acid	47-54	basigin (Ok blood group)	Homo sapiens	0-7
30440140-2	2018	The purpose of this study was to explore the association between carotid IPH and CD147, which may be the serum marker related to IPH.	iph	73-76	basigin (Ok blood group)	Homo sapiens	81-86
30440140-2	2018	The purpose of this study was to explore the association between carotid IPH and CD147, which may be the serum marker related to IPH.	iph	129-132	basigin (Ok blood group)	Homo sapiens	81-86
30440140-8	2018	Results: Serum CD147 level in IPH positive was higher than that in IPH negative, 5 510.1 vs 4 648.0 (P=0.04).	iph	30-33	basigin (Ok blood group)	Homo sapiens	15-20
30440140-8	2018	Results: Serum CD147 level in IPH positive was higher than that in IPH negative, 5 510.1 vs 4 648.0 (P=0.04).	iph	67-70	basigin (Ok blood group)	Homo sapiens	15-20
30440140-11	2018	Serum total cholesterol and LDL were positively correlated with serum CD147.	Cholesterol	12-23	basigin (Ok blood group)	Homo sapiens	70-75
30440140-13	2018	Conclusion: Serum CD147 would probably be one biomarker of IPH and shows good diagnostic value of carotid IPH in the specific population.	iph	59-62	basigin (Ok blood group)	Homo sapiens	18-23
30253283-4	2018	In previous studies, amino acid residues Lys340, Lys 384, Glu417 and Glu511 of TRAF6 were identified as the most vital residues on the basis of their contributions to interaction energy, relative solvent accessibility and electrostatic interactions in the TRAF6-Basigin protein-protein interaction (PPI) scheme.	Lysine	41-44	basigin (Ok blood group)	Homo sapiens	262-269
30253283-7	2018	Molecular dynamics simulation results suggested the substantial pharmacological importance of the ligand molecules as it was observed that there was total destabilization of TRAF6-Basigin complex upon binding of the molecule ZINC02578057.	zinc02578057	225-237	basigin (Ok blood group)	Homo sapiens	180-187
30275765-0	2018	Acid-electrolyzed functional water induces extracellular matrix metalloproteinase inducer, a possible novel alarmin, secretion from oral squamous cell carcinoma cell lines.	Water	29-34	basigin (Ok blood group)	Homo sapiens	43-89
30275765-1	2018	Extracellular matrix metalloproteinase inducer (EMMPRIN) secretion was induced in the oral squamous cell carcinoma cell line HSC3 cell by acid-electrolyzed functional water (FW) stimulation.	Water	167-172	basigin (Ok blood group)	Homo sapiens	0-46
30275765-1	2018	Extracellular matrix metalloproteinase inducer (EMMPRIN) secretion was induced in the oral squamous cell carcinoma cell line HSC3 cell by acid-electrolyzed functional water (FW) stimulation.	Water	167-172	basigin (Ok blood group)	Homo sapiens	48-55
30275765-6	2018	A significant amount of EMMPRIN was localized in the triton X-100 and DNase sensitive fractions; the levels were drastically reduced following FW treatment.	Octoxynol	53-65	basigin (Ok blood group)	Homo sapiens	24-31
30471763-5	2018	There are three glycosylation sites at three conserved asparagine (Asn 44, 152, and 186) in the CD147 N-terminal domain (Fadool et al., 1993; Tang et al., 2004; Yu et al., 2006), which could explain the molecular mass of CD147 shifts from a predicted molecular weight of about 27 kDa to 40-65 kDa with Western blotting.	Asparagine	55-65	basigin (Ok blood group)	Homo sapiens	96-101
30471763-5	2018	There are three glycosylation sites at three conserved asparagine (Asn 44, 152, and 186) in the CD147 N-terminal domain (Fadool et al., 1993; Tang et al., 2004; Yu et al., 2006), which could explain the molecular mass of CD147 shifts from a predicted molecular weight of about 27 kDa to 40-65 kDa with Western blotting.	Asparagine	55-65	basigin (Ok blood group)	Homo sapiens	221-226
30471763-5	2018	There are three glycosylation sites at three conserved asparagine (Asn 44, 152, and 186) in the CD147 N-terminal domain (Fadool et al., 1993; Tang et al., 2004; Yu et al., 2006), which could explain the molecular mass of CD147 shifts from a predicted molecular weight of about 27 kDa to 40-65 kDa with Western blotting.	Asparagine	67-70	basigin (Ok blood group)	Homo sapiens	96-101
30471763-6	2018	Inhibition of glycosylation by specific inhibitors showed that on carbohydrate side groups bearing beta-1,6-branched, polylactosamine-type sugars, fucosylations are the major glycosylation type in N-glycosylation of CD147 (Ni et al., 2014; Riethdorf et al., 2006; Tang et al., 2004).	Carbohydrates	66-78	basigin (Ok blood group)	Homo sapiens	216-221
30471763-6	2018	Inhibition of glycosylation by specific inhibitors showed that on carbohydrate side groups bearing beta-1,6-branched, polylactosamine-type sugars, fucosylations are the major glycosylation type in N-glycosylation of CD147 (Ni et al., 2014; Riethdorf et al., 2006; Tang et al., 2004).	beta-1,6-branched, polylactosamine	99-133	basigin (Ok blood group)	Homo sapiens	216-221
30471763-7	2018	In addition, N-glycosylation of CD147 has been identified as low glycosylated (approximately 32 kDa) or high glycosylated (approximately 45-65 kDa).	Nitrogen	13-14	basigin (Ok blood group)	Homo sapiens	32-37
30015874-0	2018	P2X7 receptor regulates EMMPRIN and MMP-9 expression through AMPK/MAPK signaling in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	84-87	basigin (Ok blood group)	Homo sapiens	24-31
30015874-4	2018	P2X7R may serve a crucial role in the development of atherosclerosis; therefore, the present study aimed to determine whether P2X7R regulated the expression of EMMPRIN and MMP-9 in phorbol 12-myristate 13-acetate (PMA)-induced macrophages.	Tetradecanoylphorbol Acetate	181-212	basigin (Ok blood group)	Homo sapiens	160-167
30015874-4	2018	P2X7R may serve a crucial role in the development of atherosclerosis; therefore, the present study aimed to determine whether P2X7R regulated the expression of EMMPRIN and MMP-9 in phorbol 12-myristate 13-acetate (PMA)-induced macrophages.	Tetradecanoylphorbol Acetate	214-217	basigin (Ok blood group)	Homo sapiens	160-167
30186567-2	2018	Materials and Methods: Effects of titanium particles on CD147 and RANKL mRNA were detected by QPCR; protein level of CD147 and Beclin-1 were detected by Western blot; soluble RANKL were detected by ELISA.	Titanium	34-42	basigin (Ok blood group)	Homo sapiens	56-61
30186567-4	2018	Results: Our results showed that 0.2-1.2 microm and 1.2-10 microm titanium particles up-regulate CD147 to activate autophagy, which increase the level of soluble RANKL to promote osteoclastogenesis.	Titanium	66-74	basigin (Ok blood group)	Homo sapiens	97-102
29045824-3	2018	Anti-CD147 ILs-DOX delivered DOX to CD147-overexpressing HCC cells specifically and efficiently in vitro and in vivo, resulting in enhanced therapeutic effects than non-targeted controls.	Doxorubicin	29-32	basigin (Ok blood group)	Homo sapiens	5-10
29457855-4	2018	Immunofluorescence and Western blotting were used to investigate to levels of CD147 in Human Oral Keratinocytes (HOKs) followed by TGF-beta1 or LY2157299, an inhibitor of TGF-beta1 receptor and arecoline stimulation.	Arecoline	194-203	basigin (Ok blood group)	Homo sapiens	78-83
29457855-7	2018	The TGF-beta1 signaling pathway was found to be mainly responsible for CD147 up-regulation after arecoline treatment whereas inhibition of TGF-beta1 down-regulated CD147 expression.	Arecoline	97-106	basigin (Ok blood group)	Homo sapiens	71-76
29457855-8	2018	CONCLUSION: Our findings suggest arecoline promotes CD147 expression via the TGF-beta1 signaling pathway in HOKs, whereas overexpression of CD147 may promote OSF progression.	Arecoline	33-42	basigin (Ok blood group)	Homo sapiens	52-57
30111438-6	2018	In addition to ubiquitination, lenalidomide also mediates ubiquitin-independent pathways that prevent CRBN from binding to CD147-MCT1 in a competitive manner to regulate its antitumor activity.	Lenalidomide	31-43	basigin (Ok blood group)	Homo sapiens	123-128
29045824-0	2018	Enhanced doxorubicin delivery to hepatocellular carcinoma cells via CD147 antibody-conjugated immunoliposomes.	Doxorubicin	9-20	basigin (Ok blood group)	Homo sapiens	68-73
29045824-3	2018	Anti-CD147 ILs-DOX delivered DOX to CD147-overexpressing HCC cells specifically and efficiently in vitro and in vivo, resulting in enhanced therapeutic effects than non-targeted controls.	Doxorubicin	29-32	basigin (Ok blood group)	Homo sapiens	36-41
29045824-3	2018	Anti-CD147 ILs-DOX delivered DOX to CD147-overexpressing HCC cells specifically and efficiently in vitro and in vivo, resulting in enhanced therapeutic effects than non-targeted controls.	Doxorubicin	15-18	basigin (Ok blood group)	Homo sapiens	5-10
29045824-3	2018	Anti-CD147 ILs-DOX delivered DOX to CD147-overexpressing HCC cells specifically and efficiently in vitro and in vivo, resulting in enhanced therapeutic effects than non-targeted controls.	Doxorubicin	15-18	basigin (Ok blood group)	Homo sapiens	36-41
29045824-4	2018	Strikingly, Anti-CD147 ILs-DOX reduced the CD133-positive fraction of HCC cells, suggesting its potential in reducing the number of HCC stem cells.	Doxorubicin	27-30	basigin (Ok blood group)	Homo sapiens	17-22
29045824-5	2018	Pharmacokinetic and biodistribution studies of Anti-CD147 ILs-DOX confirmed its long circulation time and efficient accumulation in tumors.	Doxorubicin	62-65	basigin (Ok blood group)	Homo sapiens	52-57
29045824-6	2018	The superior antitumor effects of Anti-CD147 ILs-DOX than other treatments were demonstrated in both HCC cells and patient-derived HCC xenograft models.	Doxorubicin	49-52	basigin (Ok blood group)	Homo sapiens	39-44
29045824-7	2018	Anti-CD147 ILs-DOX represent a novel approach for targeted HCC therapy.	Doxorubicin	15-18	basigin (Ok blood group)	Homo sapiens	5-10
29599206-6	2018	Within over-expressed proteins, hydroxycarbamide was found to enhance the expression of adhesion molecules such as Lu/BCAM and CD147, while interferon-alpha did not.	Hydroxyurea	32-48	basigin (Ok blood group)	Homo sapiens	127-132
29599206-9	2018	Furthermore, our study shows deregulation of Lu/BCAM and CD147 that are two ubiquitously expressed proteins linked to progression of solid tumors, paving the way for future studies to address the role of hydroxycarbamide in tissues other than blood cells in myeloproliferative neoplasms.	Hydroxyurea	204-220	basigin (Ok blood group)	Homo sapiens	57-62
29315565-17	2018	Moreover, the gelatin-degradation assay showed that inhibition of EMMPRIN glycosylation suppressed the Pg.	pg	103-105	basigin (Ok blood group)	Homo sapiens	66-73
29491054-0	2018	Chemotherapeutic Effect of CD147 Antibody-labeled Micelles Encapsulating Doxorubicin Conjugate Targeting CD147-Expressing Carcinoma Cells.	Doxorubicin	73-84	basigin (Ok blood group)	Homo sapiens	27-32
29431199-0	2018	N-glycosylation by N-acetylglucosaminyltransferase V enhances the interaction of CD147/basigin with integrin beta1 and promotes HCC metastasis.	Nitrogen	0-1	basigin (Ok blood group)	Homo sapiens	81-86
29431199-0	2018	N-glycosylation by N-acetylglucosaminyltransferase V enhances the interaction of CD147/basigin with integrin beta1 and promotes HCC metastasis.	Nitrogen	0-1	basigin (Ok blood group)	Homo sapiens	87-94
29431199-2	2018	In the current study, we report that GnT-V-mediated N-glycosylation of CD147/basigin, a tumor-associated glycoprotein that carries beta1,6-N-acetylglucosamine (beta1,6-GlcNAc) glycans, is upregulated during TGF-beta1-induced epithelial-to-mesenchymal transition (EMT), which correlates with tumor metastasis in patients with hepatocellular carcinoma (HCC).	Nitrogen	52-53	basigin (Ok blood group)	Homo sapiens	71-76
29431199-2	2018	In the current study, we report that GnT-V-mediated N-glycosylation of CD147/basigin, a tumor-associated glycoprotein that carries beta1,6-N-acetylglucosamine (beta1,6-GlcNAc) glycans, is upregulated during TGF-beta1-induced epithelial-to-mesenchymal transition (EMT), which correlates with tumor metastasis in patients with hepatocellular carcinoma (HCC).	Nitrogen	52-53	basigin (Ok blood group)	Homo sapiens	77-84
29431199-2	2018	In the current study, we report that GnT-V-mediated N-glycosylation of CD147/basigin, a tumor-associated glycoprotein that carries beta1,6-N-acetylglucosamine (beta1,6-GlcNAc) glycans, is upregulated during TGF-beta1-induced epithelial-to-mesenchymal transition (EMT), which correlates with tumor metastasis in patients with hepatocellular carcinoma (HCC).	Acetylglucosamine	139-158	basigin (Ok blood group)	Homo sapiens	71-76
29431199-2	2018	In the current study, we report that GnT-V-mediated N-glycosylation of CD147/basigin, a tumor-associated glycoprotein that carries beta1,6-N-acetylglucosamine (beta1,6-GlcNAc) glycans, is upregulated during TGF-beta1-induced epithelial-to-mesenchymal transition (EMT), which correlates with tumor metastasis in patients with hepatocellular carcinoma (HCC).	Acetylglucosamine	139-158	basigin (Ok blood group)	Homo sapiens	77-84
29431199-2	2018	In the current study, we report that GnT-V-mediated N-glycosylation of CD147/basigin, a tumor-associated glycoprotein that carries beta1,6-N-acetylglucosamine (beta1,6-GlcNAc) glycans, is upregulated during TGF-beta1-induced epithelial-to-mesenchymal transition (EMT), which correlates with tumor metastasis in patients with hepatocellular carcinoma (HCC).	Polysaccharides	176-183	basigin (Ok blood group)	Homo sapiens	71-76
29431199-2	2018	In the current study, we report that GnT-V-mediated N-glycosylation of CD147/basigin, a tumor-associated glycoprotein that carries beta1,6-N-acetylglucosamine (beta1,6-GlcNAc) glycans, is upregulated during TGF-beta1-induced epithelial-to-mesenchymal transition (EMT), which correlates with tumor metastasis in patients with hepatocellular carcinoma (HCC).	Polysaccharides	176-183	basigin (Ok blood group)	Homo sapiens	77-84
29431199-3	2018	Interruption of beta1,6-GlcNAc glycan modification of CD147/basigin decreased matrix metalloproteinase (MMP) expression in HCC cell lines and affected the interaction of CD147/basigin with integrin beta1.	beta1,6-glcnac	16-30	basigin (Ok blood group)	Homo sapiens	54-59
29431199-3	2018	Interruption of beta1,6-GlcNAc glycan modification of CD147/basigin decreased matrix metalloproteinase (MMP) expression in HCC cell lines and affected the interaction of CD147/basigin with integrin beta1.	beta1,6-glcnac	16-30	basigin (Ok blood group)	Homo sapiens	60-67
29431199-3	2018	Interruption of beta1,6-GlcNAc glycan modification of CD147/basigin decreased matrix metalloproteinase (MMP) expression in HCC cell lines and affected the interaction of CD147/basigin with integrin beta1.	beta1,6-glcnac	16-30	basigin (Ok blood group)	Homo sapiens	170-175
29431199-3	2018	Interruption of beta1,6-GlcNAc glycan modification of CD147/basigin decreased matrix metalloproteinase (MMP) expression in HCC cell lines and affected the interaction of CD147/basigin with integrin beta1.	beta1,6-glcnac	16-30	basigin (Ok blood group)	Homo sapiens	176-183
29431199-3	2018	Interruption of beta1,6-GlcNAc glycan modification of CD147/basigin decreased matrix metalloproteinase (MMP) expression in HCC cell lines and affected the interaction of CD147/basigin with integrin beta1.	Polysaccharides	31-37	basigin (Ok blood group)	Homo sapiens	54-59
29431199-3	2018	Interruption of beta1,6-GlcNAc glycan modification of CD147/basigin decreased matrix metalloproteinase (MMP) expression in HCC cell lines and affected the interaction of CD147/basigin with integrin beta1.	Polysaccharides	31-37	basigin (Ok blood group)	Homo sapiens	60-67
29431199-3	2018	Interruption of beta1,6-GlcNAc glycan modification of CD147/basigin decreased matrix metalloproteinase (MMP) expression in HCC cell lines and affected the interaction of CD147/basigin with integrin beta1.	Polysaccharides	31-37	basigin (Ok blood group)	Homo sapiens	170-175
29634399-9	2018	Our mechanistic studies demonstrate that, through directly repressing the expression of the CD147 protein, miR-125a-5p suppresses aerobic glycolysis and lactate production and subsequently reduces TC cell viability, migration, and invasion, thereby exerting tumor suppressor functions.	Lactic Acid	153-160	basigin (Ok blood group)	Homo sapiens	92-97
29695106-2	2018	Basigin (BSG, CD147) controls lactate export through the monocarboxylic acid transporter 1 (MCT1, SLC16A1) and supports MM survival and proliferation.	Lactic Acid	30-37	basigin (Ok blood group)	Homo sapiens	0-7
29695106-2	2018	Basigin (BSG, CD147) controls lactate export through the monocarboxylic acid transporter 1 (MCT1, SLC16A1) and supports MM survival and proliferation.	Lactic Acid	30-37	basigin (Ok blood group)	Homo sapiens	9-12
29695106-2	2018	Basigin (BSG, CD147) controls lactate export through the monocarboxylic acid transporter 1 (MCT1, SLC16A1) and supports MM survival and proliferation.	Lactic Acid	30-37	basigin (Ok blood group)	Homo sapiens	14-19
29695106-3	2018	Additionally, BSG is implicated in response to treatment with immunomodulatory drugs (thalidomide and its derivatives).	Thalidomide	86-97	basigin (Ok blood group)	Homo sapiens	14-17
29431199-3	2018	Interruption of beta1,6-GlcNAc glycan modification of CD147/basigin decreased matrix metalloproteinase (MMP) expression in HCC cell lines and affected the interaction of CD147/basigin with integrin beta1.	Polysaccharides	31-37	basigin (Ok blood group)	Homo sapiens	176-183
29431199-4	2018	These results reveal that beta1,6-branched glycans modulate the biological function of CD147/basigin in HCC metastasis.	beta1,6-branched glycans	26-50	basigin (Ok blood group)	Homo sapiens	87-92
29431199-4	2018	These results reveal that beta1,6-branched glycans modulate the biological function of CD147/basigin in HCC metastasis.	beta1,6-branched glycans	26-50	basigin (Ok blood group)	Homo sapiens	93-100
29431199-6	2018	In summary, beta1,6-branched N-glycosylation affects the biological function of CD147/basigin and these findings provide a novel approach for the development of therapeutic strategies targeting metastasis.	beta1,6-branched n	12-30	basigin (Ok blood group)	Homo sapiens	80-85
29431199-6	2018	In summary, beta1,6-branched N-glycosylation affects the biological function of CD147/basigin and these findings provide a novel approach for the development of therapeutic strategies targeting metastasis.	beta1,6-branched n	12-30	basigin (Ok blood group)	Homo sapiens	86-93
29491054-0	2018	Chemotherapeutic Effect of CD147 Antibody-labeled Micelles Encapsulating Doxorubicin Conjugate Targeting CD147-Expressing Carcinoma Cells.	Doxorubicin	73-84	basigin (Ok blood group)	Homo sapiens	105-110
29491054-3	2018	RESULTS: By treatment of each cell type with CD147ab micelles for 1 h, a specific accumulation of CD147ab micelles in CD147-expressing cells was observed.	cd147ab	98-105	basigin (Ok blood group)	Homo sapiens	45-50
29491054-5	2018	CONCLUSION: These results suggest that GSH-DXR-encapsulated CD147ab micelles could serve as an effective drug delivery system to CD147-expressing carcinoma cells.	Glutathione	39-42	basigin (Ok blood group)	Homo sapiens	60-65
29491054-5	2018	CONCLUSION: These results suggest that GSH-DXR-encapsulated CD147ab micelles could serve as an effective drug delivery system to CD147-expressing carcinoma cells.	Glutathione	39-42	basigin (Ok blood group)	Homo sapiens	129-134
28822092-0	2018	Zn(II) can mediate self-association of the extracellular C-terminal domain of CD147.	Zinc	0-6	basigin (Ok blood group)	Homo sapiens	78-83
29247133-6	2018	Exposure of cells to DHT, upregulated the gene and protein expression of AR, EMMPRIN and MMP-9 and downregulated the expression of MMP-2 DHT significantly induced the release of nitric oxide by MSC (>=2-fold) and flutamide blocked this effect.	Dihydrotestosterone	21-24	basigin (Ok blood group)	Homo sapiens	77-84
29476273-0	2018	Targeted Delivery of Doxorubicin via CD147-Mediated ROS/pH Dual-Sensitive Nanomicelles for the Efficient Therapy of Hepatocellular Carcinoma.	Doxorubicin	21-32	basigin (Ok blood group)	Homo sapiens	37-42
29476273-0	2018	Targeted Delivery of Doxorubicin via CD147-Mediated ROS/pH Dual-Sensitive Nanomicelles for the Efficient Therapy of Hepatocellular Carcinoma.	Reactive Oxygen Species	52-55	basigin (Ok blood group)	Homo sapiens	37-42
29476273-7	2018	In conclusion, this CD147 receptor targeted delivery system with ROS/pH dual sensitivity provides a promising strategy for the treatment of hepatic carcinoma.	Reactive Oxygen Species	65-68	basigin (Ok blood group)	Homo sapiens	20-25
29362238-6	2018	Searching for gene-wide episodic selection across the entire Laverania phylogeny, we found eight codons to be under positive selection, including three that correspond to contact residues known to form hydrogen bonds between P. falciparum RH5 and human basigin.	Hydrogen	202-210	basigin (Ok blood group)	Homo sapiens	253-260
29719608-6	2018	Mechanistically, beta3GnT8 modulated the N-glycosylation patterns of CD147 and altered the polylactosamine structures in HCC cells by physically interacting with CD147.	Nitrogen	41-42	basigin (Ok blood group)	Homo sapiens	69-74
28684116-8	2017	Furthermore, we report that a phosphoserine (pSer) in CD147 (pSer252) is responsible for this interaction and inhibition of the Smad4/p21WAF1 signal that promotes cell proliferation.	pser252	61-68	basigin (Ok blood group)	Homo sapiens	54-59
29088427-0	2017	Abnormal creatine transport of mutations in monocarboxylate transporter 12 (MCT12) found in patients with age-related cataract can be partially rescued by exogenous chaperone CD147.	Creatine	9-17	basigin (Ok blood group)	Homo sapiens	175-180
29267289-6	2017	MAb216 displays direct antibody mediated cytotoxicity on a population of human EOC tumor and ascites samples and EOC cell lines, which express high amounts of poly N-acetyllactosamine epitope, carried by CD147/CD98.	poly-N-acetyllactosamine	159-183	basigin (Ok blood group)	Homo sapiens	204-209
29149784-0	2017	Anti-inflammatory Property of beta-D-Mannuronic Acid (M2000) on Expression and Activity of Matrix Metalloproteinase-2 and -9 through CD147 Molecule in Phorbol Myristate Acetate-differentiated THP-1 Cells.	mannuronic acid	30-52	basigin (Ok blood group)	Homo sapiens	133-138
29149784-0	2017	Anti-inflammatory Property of beta-D-Mannuronic Acid (M2000) on Expression and Activity of Matrix Metalloproteinase-2 and -9 through CD147 Molecule in Phorbol Myristate Acetate-differentiated THP-1 Cells.	Tetradecanoylphorbol Acetate	151-176	basigin (Ok blood group)	Homo sapiens	133-138
29034777-8	2017	The results demonstrated that doxycycline inhibited cell proliferation, reduced CD147 expression level, and induced an early-stage apoptosis response in GBC-SD and SGC-996 cells.	Doxycycline	30-41	basigin (Ok blood group)	Homo sapiens	80-85
29034777-10	2017	Taken together, doxycycline showed inhibitory effects on gallbladder carcinoma cell lines and reduced the expression of CD147, and this may be the mechanism by which doxycycline inhibits cancer cells.	Doxycycline	16-27	basigin (Ok blood group)	Homo sapiens	120-125
29034777-10	2017	Taken together, doxycycline showed inhibitory effects on gallbladder carcinoma cell lines and reduced the expression of CD147, and this may be the mechanism by which doxycycline inhibits cancer cells.	Doxycycline	166-177	basigin (Ok blood group)	Homo sapiens	120-125
28684116-8	2017	Furthermore, we report that a phosphoserine (pSer) in CD147 (pSer252) is responsible for this interaction and inhibition of the Smad4/p21WAF1 signal that promotes cell proliferation.	Phosphoserine	30-43	basigin (Ok blood group)	Homo sapiens	54-59
28721406-0	2017	Chemical proteomics reveal CD147 as a functional target of pseudolaric acid B in human cancer cells.	pseudolaric acid B	59-77	basigin (Ok blood group)	Homo sapiens	27-32
28721406-2	2017	We report the discovery of the natural product pseudolaric acid B (PAB) directly targeting CD147 by chemical proteomics utilizing a PAB-derived photoaffinity probe which could serve as a novel type of anticancer reagent.	pseudolaric acid B	47-65	basigin (Ok blood group)	Homo sapiens	91-96
28721406-2	2017	We report the discovery of the natural product pseudolaric acid B (PAB) directly targeting CD147 by chemical proteomics utilizing a PAB-derived photoaffinity probe which could serve as a novel type of anticancer reagent.	pseudolaric acid B	67-70	basigin (Ok blood group)	Homo sapiens	91-96
28721406-2	2017	We report the discovery of the natural product pseudolaric acid B (PAB) directly targeting CD147 by chemical proteomics utilizing a PAB-derived photoaffinity probe which could serve as a novel type of anticancer reagent.	pseudolaric acid B	132-135	basigin (Ok blood group)	Homo sapiens	91-96
28267620-1	2017	BACKGROUND & AIMS: Large extracellular vesicles, specifically AnnexinV+ EpCAM+ CD147+ tumour-associated microparticles (taMPs), facilitate the detection of colorectal carcinoma (CRC), non-small cell lung carcinoma (NSCLC) as well as pancreas carcinoma (PaCa).	Adenosine Monophosphate	12-15	basigin (Ok blood group)	Homo sapiens	83-88
28789363-0	2017	Surgery combined with local 5-aminolevulinic acid-photodynamic therapy on skin cancer and its effect on the expression of cyclophilin A, cyclophilin B and CD147.	5-amino levulinic acid	28-49	basigin (Ok blood group)	Homo sapiens	155-160
28498412-6	2017	Microvesicles released from FU-EPS-1 cells were shown to contain full-length emmprin, identified as a 45-kDa protein characterized by polylactosamine glycosylation.	polylactosamine	134-149	basigin (Ok blood group)	Homo sapiens	77-84
28571672-4	2017	Using T cell-specific deletion, we showed here that in thymus CD147 is indispensable for the stable alphabeta T cell lineage commitment: loss of CD147 biases both multipotent DN (double negative) and fully committed DP (double positive) cells into innate NK-like lineages.	dp	216-218	basigin (Ok blood group)	Homo sapiens	62-67
28571672-4	2017	Using T cell-specific deletion, we showed here that in thymus CD147 is indispensable for the stable alphabeta T cell lineage commitment: loss of CD147 biases both multipotent DN (double negative) and fully committed DP (double positive) cells into innate NK-like lineages.	dp	216-218	basigin (Ok blood group)	Homo sapiens	145-150
28017969-3	2017	Recently, Basigin (BSG) was identified as another protein regulated by CRBN that is involved in the activity of lenalidomide.	Lenalidomide	112-124	basigin (Ok blood group)	Homo sapiens	10-17
28703811-6	2017	In this study, we discovered that under low-cholesterol condition, CD147 endocytosis is inhibited but its shedding mediated by ADAM10 is enhanced.	Cholesterol	44-55	basigin (Ok blood group)	Homo sapiens	67-72
28017969-3	2017	Recently, Basigin (BSG) was identified as another protein regulated by CRBN that is involved in the activity of lenalidomide.	Lenalidomide	112-124	basigin (Ok blood group)	Homo sapiens	19-22
28881637-0	2017	CD147 functions as the signaling receptor for extracellular divalent copper in hepatocellular carcinoma cells.	Copper	69-75	basigin (Ok blood group)	Homo sapiens	0-5
28465354-5	2017	EGCG + IIF was also the most active treatment in reducing the expression of markers of invasion and migration in all the three cell lines: CD44, EMMPRIN, MMP-2 and -9 expression decreased, whereas TIMPs were up-regulated.	epigallocatechin gallate	0-4	basigin (Ok blood group)	Homo sapiens	145-152
28465354-7	2017	We considered that EGCG and IIF treatments could alter the molecular network based on EGFR, CD44 and EMMPRIN expression interdependence and reduced the migration tendency in MCF-7, MCF-7TAM and MDA-MB-231 cells.	epigallocatechin gallate	19-23	basigin (Ok blood group)	Homo sapiens	101-108
28881637-4	2017	Here we report that CD147 serves as a signaling receptor for extracellular Cu2+ in hepatocellular carcinoma (HCC) cells.	cupric ion	75-79	basigin (Ok blood group)	Homo sapiens	20-25
28881637-5	2017	Cu2+ binds to the extracellular membrane-proximal domain of CD147 and mediates its self-association.	cupric ion	0-4	basigin (Ok blood group)	Homo sapiens	60-65
28881637-6	2017	Cu2+-mediated self-association of CD147 activates PI3K/Akt signaling pathway leading to the up-regulation of matrix metalloproteinase MMP-2 and MMP-14 in HCC cells.	cupric ion	0-4	basigin (Ok blood group)	Homo sapiens	34-39
28881637-7	2017	Cu2+-induced CD147 self-association also enhances the ability of HCC cells to stimulate MMP-2 expression from neighboring fibroblasts, as well as increases the invasiveness of HCC cells which is abolished by the copper chelator tetrathiomolybdate.	cupric ion	0-4	basigin (Ok blood group)	Homo sapiens	13-18
28881637-7	2017	Cu2+-induced CD147 self-association also enhances the ability of HCC cells to stimulate MMP-2 expression from neighboring fibroblasts, as well as increases the invasiveness of HCC cells which is abolished by the copper chelator tetrathiomolybdate.	Copper	212-218	basigin (Ok blood group)	Homo sapiens	13-18
28881637-7	2017	Cu2+-induced CD147 self-association also enhances the ability of HCC cells to stimulate MMP-2 expression from neighboring fibroblasts, as well as increases the invasiveness of HCC cells which is abolished by the copper chelator tetrathiomolybdate.	tetrathiomolybdate	228-246	basigin (Ok blood group)	Homo sapiens	13-18
28881637-8	2017	We have mapped the interfaces and identified the key residues of CD147 involved in the Cu2+ induced self-association.	cupric ion	87-91	basigin (Ok blood group)	Homo sapiens	65-70
28881637-9	2017	The Cu2+ binding deficient CD147 mutant abolishes the stimulating effects of Cu2+ on HCC cells.	cupric ion	4-8	basigin (Ok blood group)	Homo sapiens	27-32
28881637-9	2017	The Cu2+ binding deficient CD147 mutant abolishes the stimulating effects of Cu2+ on HCC cells.	cupric ion	77-81	basigin (Ok blood group)	Homo sapiens	27-32
28881637-10	2017	Our study reveals a novel extracellular signaling role of copper in promoting cancer cell metastasis, which implies that targeting the Cu2+-induced self-association of CD147 is a new strategy for cancer treatment.	Copper	58-64	basigin (Ok blood group)	Homo sapiens	168-173
28881637-10	2017	Our study reveals a novel extracellular signaling role of copper in promoting cancer cell metastasis, which implies that targeting the Cu2+-induced self-association of CD147 is a new strategy for cancer treatment.	cupric ion	135-139	basigin (Ok blood group)	Homo sapiens	168-173
28243336-6	2017	Further studies showed that the regulated beta3GnT8 could convert the heterogeneous N-glycosylated forms of CD147 and change the polylactosamine structures carried on CD147.	Nitrogen	84-85	basigin (Ok blood group)	Homo sapiens	108-113
28283413-6	2017	Solasodine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK), as well as tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2.	solasodine	0-10	basigin (Ok blood group)	Homo sapiens	134-141
28381172-9	2017	Furthermore, PI3K/AKT pathway and SOX2 were found necessary to maintain the stemness of CD147+ BCSCs by using LY294002 or lentiviral-si-SOX2.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	110-118	basigin (Ok blood group)	Homo sapiens	88-93
28450907-7	2017	The THP-1 cell line was used to investigate the effect of atorvastatin on EMMPRIN expression in vitro.	Atorvastatin	58-70	basigin (Ok blood group)	Homo sapiens	74-81
28017969-9	2017	Our data suggest a prognostic role of IKZF1, IKZF3 and BSG expression levels in lenalidomide-treated multiple myeloma.	Lenalidomide	80-92	basigin (Ok blood group)	Homo sapiens	55-58
28333070-5	2017	METHODS: Differential expression of MCT1, MCT4 and CD147 obtained by qPCR was determined by 2-DeltaDeltaCq method between biological samples (tumor and serial samples of peripheral) of patients (n = 125) and healthy women (n = 25).	2-deltadeltacq	92-106	basigin (Ok blood group)	Homo sapiens	51-56
28261097-0	2017	Curcumin Alleviates oxLDL Induced MMP-9 and EMMPRIN Expression through the Inhibition of NF-kappaB and MAPK Pathways in Macrophages.	Curcumin	0-8	basigin (Ok blood group)	Homo sapiens	44-51
28261097-4	2017	Here we evaluated the impact of curcumin on the expression of MMP-9 and EMMPRIN in macrophages.	Curcumin	32-40	basigin (Ok blood group)	Homo sapiens	72-79
28261097-8	2017	Here we showed that curcumin attenuated the MMP-9 and EMMPRIN expression in oxLDL stimulated macrophages.	Curcumin	20-28	basigin (Ok blood group)	Homo sapiens	54-61
28261097-10	2017	These findings illustrated that curcumin can inhibit the expression of EMMPRIN and MMP-9 in oxLDL stimulated macrophages through down regulation of NF-kappaB and p38 MAPK signaling pathways, which might be the molecular mechanism for the anti-atherosclerotic effect of curcumin.	Curcumin	32-40	basigin (Ok blood group)	Homo sapiens	71-78
28261097-10	2017	These findings illustrated that curcumin can inhibit the expression of EMMPRIN and MMP-9 in oxLDL stimulated macrophages through down regulation of NF-kappaB and p38 MAPK signaling pathways, which might be the molecular mechanism for the anti-atherosclerotic effect of curcumin.	Curcumin	269-277	basigin (Ok blood group)	Homo sapiens	71-78
28243336-6	2017	Further studies showed that the regulated beta3GnT8 could convert the heterogeneous N-glycosylated forms of CD147 and change the polylactosamine structures carried on CD147.	Nitrogen	84-85	basigin (Ok blood group)	Homo sapiens	167-172
28243336-6	2017	Further studies showed that the regulated beta3GnT8 could convert the heterogeneous N-glycosylated forms of CD147 and change the polylactosamine structures carried on CD147.	polylactosamine	129-144	basigin (Ok blood group)	Homo sapiens	167-172
28062212-7	2017	Further investigation revealed that either rescue expression of CD147 or treatment of MAPK/ERK activator phorbol 12-myristate 13-acetate (PMA) in CD147 knockdown CRC cell line attenuated the decreased chemoresistance in CD147 knockdown cells.	Tetradecanoylphorbol Acetate	105-136	basigin (Ok blood group)	Homo sapiens	146-151
28062212-7	2017	Further investigation revealed that either rescue expression of CD147 or treatment of MAPK/ERK activator phorbol 12-myristate 13-acetate (PMA) in CD147 knockdown CRC cell line attenuated the decreased chemoresistance in CD147 knockdown cells.	Tetradecanoylphorbol Acetate	105-136	basigin (Ok blood group)	Homo sapiens	146-151
28062212-7	2017	Further investigation revealed that either rescue expression of CD147 or treatment of MAPK/ERK activator phorbol 12-myristate 13-acetate (PMA) in CD147 knockdown CRC cell line attenuated the decreased chemoresistance in CD147 knockdown cells.	Tetradecanoylphorbol Acetate	138-141	basigin (Ok blood group)	Homo sapiens	146-151
28062212-7	2017	Further investigation revealed that either rescue expression of CD147 or treatment of MAPK/ERK activator phorbol 12-myristate 13-acetate (PMA) in CD147 knockdown CRC cell line attenuated the decreased chemoresistance in CD147 knockdown cells.	Tetradecanoylphorbol Acetate	138-141	basigin (Ok blood group)	Homo sapiens	146-151
28039486-4	2017	The interactions with transmembrane small molecule and ion transporters identified here indicate a central role of CD147 in pancreatic cancer metabolic reprogramming, particularly with respect to amino acid anabolism and calcium signaling.	Calcium	221-228	basigin (Ok blood group)	Homo sapiens	115-120
28117675-0	2017	F-Box Protein FBXO22 Mediates Polyubiquitination and Degradation of CD147 to Reverse Cisplatin Resistance of Tumor Cells.	Cisplatin	85-94	basigin (Ok blood group)	Homo sapiens	68-73
28117675-11	2017	To conclude, our study demonstrated that FBXO22 mediated the polyubiquitination and degradation of CD147 by interacting with CD147-ICD, and CD147 polyubiquitination by FBXO22 reversed cisplatin resistance of tumor cells.	Cisplatin	184-193	basigin (Ok blood group)	Homo sapiens	99-104
28117675-11	2017	To conclude, our study demonstrated that FBXO22 mediated the polyubiquitination and degradation of CD147 by interacting with CD147-ICD, and CD147 polyubiquitination by FBXO22 reversed cisplatin resistance of tumor cells.	Cisplatin	184-193	basigin (Ok blood group)	Homo sapiens	125-130
27869218-1	2016	Cluster of differentiation 147 (CD147), also known as extracellular matrix metalloproteinase inducer, is a transmembrane glycoprotein that mediates oncogenic processes partly through N-glycosylation modifications.	Nitrogen	183-184	basigin (Ok blood group)	Homo sapiens	54-100
27847199-0	2016	Triptolide inhibits the migration and invasion of human prostate cancer cells via Caveolin-1/CD147/MMPs pathway.	triptolide	0-10	basigin (Ok blood group)	Homo sapiens	93-98
27847199-6	2016	Triptolide treatment inhibited the expression of tumor promoter Cav-1 and reduced CD147 and MMPs activities at both mRNA and protein levels.	triptolide	0-10	basigin (Ok blood group)	Homo sapiens	82-87
27847199-8	2016	Together, our research indicates that triptolide represses the migration and invasion through Cav-1/CD147/MMPs pathway in PCa cells, which gives a better understanding of triptolide in clinical aggressive prostate cancer therapy.	triptolide	38-48	basigin (Ok blood group)	Homo sapiens	100-105
27847199-8	2016	Together, our research indicates that triptolide represses the migration and invasion through Cav-1/CD147/MMPs pathway in PCa cells, which gives a better understanding of triptolide in clinical aggressive prostate cancer therapy.	triptolide	171-181	basigin (Ok blood group)	Homo sapiens	100-105
27769052-6	2016	Moreover, we showed that the CBD-THC combination was able to reduce MM cells migration by down-regulating expression of the chemokine receptor CXCR4 and of the CD147 plasma membrane glycoprotein.	cbd-thc	29-36	basigin (Ok blood group)	Homo sapiens	160-165
27737732-0	2016	Anacardic acid inhibits gelatinases through the regulation of Spry2, MMP-14, EMMPRIN and RECK.	anacardic acid	0-14	basigin (Ok blood group)	Homo sapiens	77-84
27619643-5	2016	After CD147 stealth siRNA transfection treatment, the production of VEGF was reduced depended on the inhibition efficiency of CD147 siRNAs.The special signaling pathway inhibitors LY294002, SP600125, SB203580 and U0126 were added to cultures respectively and the results showed LY294002 dose-dependently inhibited the expression of VEGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	180-188	basigin (Ok blood group)	Homo sapiens	6-11
27619643-5	2016	After CD147 stealth siRNA transfection treatment, the production of VEGF was reduced depended on the inhibition efficiency of CD147 siRNAs.The special signaling pathway inhibitors LY294002, SP600125, SB203580 and U0126 were added to cultures respectively and the results showed LY294002 dose-dependently inhibited the expression of VEGF.	SB 203580	200-208	basigin (Ok blood group)	Homo sapiens	6-11
27619643-5	2016	After CD147 stealth siRNA transfection treatment, the production of VEGF was reduced depended on the inhibition efficiency of CD147 siRNAs.The special signaling pathway inhibitors LY294002, SP600125, SB203580 and U0126 were added to cultures respectively and the results showed LY294002 dose-dependently inhibited the expression of VEGF.	U 0126	213-218	basigin (Ok blood group)	Homo sapiens	6-11
27619643-5	2016	After CD147 stealth siRNA transfection treatment, the production of VEGF was reduced depended on the inhibition efficiency of CD147 siRNAs.The special signaling pathway inhibitors LY294002, SP600125, SB203580 and U0126 were added to cultures respectively and the results showed LY294002 dose-dependently inhibited the expression of VEGF.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	278-286	basigin (Ok blood group)	Homo sapiens	6-11
27619643-6	2016	The reduction of phospho-Akt was observed in both LY294002 and siRNA groups, suggested that the phosphatidylinositol 3-kinase/Akt pathway may be the probable signaling pathway underlying CD147 induced up-regulation of VEGF in U937-derived foam cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	50-58	basigin (Ok blood group)	Homo sapiens	187-192
27041581-3	2016	We demonstrated that TGF-beta1 stimulation upregulated CD147 expression and mediated the dedifferentiation of HCC cells, whereas all-trans-retinoic acid induced the downregulation of CD147 and promoted differentiation in HCC cells.	Tretinoin	133-152	basigin (Ok blood group)	Homo sapiens	183-188
27519006-3	2016	Detailed site-specific reference glycoprofiles of purified basigin were manually established using ion-trap CID-MS/MS and high-resolution Q-Exactive Orbitrap HCD-MS/MS of tryptic N-glycopeptides and released N-glycans.	n-glycopeptides	179-194	basigin (Ok blood group)	Homo sapiens	59-66
27556188-0	2016	CD147 silencing inhibits tumor growth by suppressing glucose transport in melanoma.	Glucose	53-60	basigin (Ok blood group)	Homo sapiens	0-5
27556188-7	2016	Silencing CD147 by specific siRNA could downregulate GLUT-1 level via inhibiting PI3K/Akt signaling and decrease glucose uptake in A375 cells.	Glucose	113-120	basigin (Ok blood group)	Homo sapiens	10-15
27519006-3	2016	Detailed site-specific reference glycoprofiles of purified basigin were manually established using ion-trap CID-MS/MS and high-resolution Q-Exactive Orbitrap HCD-MS/MS of tryptic N-glycopeptides and released N-glycans.	n-glycans	208-217	basigin (Ok blood group)	Homo sapiens	59-66
27519006-4	2016	The micro- and macroheterogeneous basigin N-glycosylation was site-specifically glycoprofiled using Byonic with or without a background of complex peptides using Q-Exactive Orbitrap HCD-MS/MS.	Nitrogen	42-43	basigin (Ok blood group)	Homo sapiens	34-41
27498922-15	2016	This study identified that combination of nadroparin and irradiation had a strong synergistic antitumor effect in a dose- and time-related manner in vitro, which was reflected in the inhibition of cell viability, invasion and metastasis, promotion of apoptosis, inhibited secretion level of TGF-beta1 and downregulation of CD147, MMP-2 and survivin expression.	Nadroparin	42-52	basigin (Ok blood group)	Homo sapiens	323-328
28874966-6	2016	CRC cell exposure to acetate upregulates the expression of MCT1, MCT4 and CD147, while promoting MCT1 plasma membrane localization.	Acetates	21-28	basigin (Ok blood group)	Homo sapiens	74-79
27556697-0	2016	Gemcitabine enhances cell invasion via activating HAb18G/CD147-EGFR-pSTAT3 signaling.	gemcitabine	0-11	basigin (Ok blood group)	Homo sapiens	57-62
27556697-7	2016	In gemcitabine-treated cells, HAb18G/CD147 was up-regulated; and HAb18G/CD147 down-regulation or inhibition attenuated gemcitabine-enhanced invasion.	gemcitabine	3-14	basigin (Ok blood group)	Homo sapiens	37-42
27556697-7	2016	In gemcitabine-treated cells, HAb18G/CD147 was up-regulated; and HAb18G/CD147 down-regulation or inhibition attenuated gemcitabine-enhanced invasion.	gemcitabine	119-130	basigin (Ok blood group)	Homo sapiens	72-77
27556697-8	2016	Mechanistically, HAb18G/CD147 promoted gemcitabine-enhanced invasion by activating the EGFR (epidermal growth factor receptor)-STAT3 (signal transducer and activator of transcription 3) signaling pathway.	gemcitabine	39-50	basigin (Ok blood group)	Homo sapiens	24-29
27556697-9	2016	Inhibition of EGFR-STAT3 signaling counteracted gemcitabine-enhanced invasion, and which relied on HAb18G/CD147 levels.	gemcitabine	48-59	basigin (Ok blood group)	Homo sapiens	106-111
26293643-7	2016	Moreover, UCH-L1-overexpressing clones treated with U0126 (an Erk1/2-specific inhibitor) significantly decreased the expression of MDR1, CD147, MMP2, and MMP9.	U 0126	52-57	basigin (Ok blood group)	Homo sapiens	137-142
27503893-4	2016	Mutational analyses of BSG showed that the atypical glutamic acid in the transmembrane region is required for BSG"s association with Xkr8.	Glutamic Acid	52-65	basigin (Ok blood group)	Homo sapiens	23-26
27446405-10	2016	Furthermore, inhibition of PI3K/Akt with LY294002 augmented CD147-mediated function.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	basigin (Ok blood group)	Homo sapiens	60-65
27503893-4	2016	Mutational analyses of BSG showed that the atypical glutamic acid in the transmembrane region is required for BSG"s association with Xkr8.	Glutamic Acid	52-65	basigin (Ok blood group)	Homo sapiens	110-113
27503893-5	2016	In cells exposed to apoptotic signals, Xkr8 was cleaved at the C terminus and the Xkr8/BSG complex formed a higher-order complex, likely to be a heterotetramer consisting of two molecules of Xkr8 and two molecules of BSG or NPTN, suggesting that this cleavage causes the formation of a larger complex of Xkr8-BSG/NPTN for phospholipid scrambling.	Phospholipids	322-334	basigin (Ok blood group)	Homo sapiens	87-90
27294876-4	2016	This process allows for the formation and activation of the CD147-MCT1 transmembrane complex, which promotes various biological functions, including angiogenesis, proliferation, invasion and lactate export.	Lactic Acid	191-198	basigin (Ok blood group)	Homo sapiens	60-65
27294876-6	2016	Accordingly, IMiD-sensitive MM cells lose CD147 and MCT1 expression after being exposed to IMiDs, whereas IMiD-resistant cells retain their expression.	imid	13-17	basigin (Ok blood group)	Homo sapiens	42-47
26996298-4	2016	Leptin action was effective in both low and high glycolytic cancer cell lines, and determined the up-regulation of lactate exporter MCT4 and its associated protein CD147.	Lactic Acid	115-122	basigin (Ok blood group)	Homo sapiens	164-169
27349797-8	2016	Moreover, BDMC inhibited expressions of several degradation-associated proteins, such as matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), CD147, urokinase plasminogen activator (uPA), intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1), whereas increased expression of tissue inhibitor of metalloproteinase-1 (TIMP-1), in a dose-dependent manner.	bisdemethoxycurcumin	10-14	basigin (Ok blood group)	Homo sapiens	161-166
27420938-0	2016	SNP at miR-483-5p-binding site in the 3"-untranslated region of the BSG gene is associated with susceptibility to esophageal cancer in a Chinese population.	CHEMBL3740941	15-17	basigin (Ok blood group)	Homo sapiens	68-71
27429847-5	2016	In addition, physcion treatment significantly inhibited extracellular matrix metalloproteinase inducer (EMMPRIN) expression in MG-63 cells, in a dose-dependent manner; meanwhile, EMMPRIN protein overexpression markedly reduced PG-induced apoptosis.	physcion 8-O-glucopyranoside	227-229	basigin (Ok blood group)	Homo sapiens	179-186
27429847-6	2016	Moreover, our findings suggested that the modulatory effects of PG on EMMPRIN were due, at least in part, to regulation of an ROS-miR-27a/ZBTB10-Sp1 transcription factor pathway.	physcion 8-O-glucopyranoside	64-66	basigin (Ok blood group)	Homo sapiens	70-77
27429847-6	2016	Moreover, our findings suggested that the modulatory effects of PG on EMMPRIN were due, at least in part, to regulation of an ROS-miR-27a/ZBTB10-Sp1 transcription factor pathway.	ros	126-129	basigin (Ok blood group)	Homo sapiens	70-77
26684586-6	2016	The carbohydrate portion of basigin is recognized by lectins, such as galectin-3 and E-selectin.	Carbohydrates	4-16	basigin (Ok blood group)	Homo sapiens	28-35
26782265-0	2016	NS-398 promotes pancreatic cancer cell invasion by CD147 and MMP-2 via the activation of P38.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	0-6	basigin (Ok blood group)	Homo sapiens	51-56
26496775-9	2016	Our study suggests that upregulation of CD147 under starvation may reduce hepatoma cell death by modulating both apoptosis and autophagy through mTOR signaling, and that CD147 may be a novel potential molecular target to improve the efficacy of TACE.	Chlorotrianisene	245-249	basigin (Ok blood group)	Homo sapiens	40-45
26496775-9	2016	Our study suggests that upregulation of CD147 under starvation may reduce hepatoma cell death by modulating both apoptosis and autophagy through mTOR signaling, and that CD147 may be a novel potential molecular target to improve the efficacy of TACE.	Chlorotrianisene	245-249	basigin (Ok blood group)	Homo sapiens	170-175
26716413-3	2016	In this study, we demonstrated that CD147 physically interacted with the N-terminal domain of Annexin A2 and decreased Annexin A2 phosphorylation on tyrosine 23.	Tyrosine	149-157	basigin (Ok blood group)	Homo sapiens	36-41
26729804-0	2016	Association of CD147 and Calcium Exporter PMCA4 Uncouples IL-2 Expression from Early TCR Signaling.	Calcium	25-32	basigin (Ok blood group)	Homo sapiens	15-20
26729804-7	2016	CD147 does not control the proper membrane localization of PMCA4, but PMCA4 is essential for the CD147-dependent inhibition of IL-2 expression via a calcium-independent mechanism.	Calcium	149-156	basigin (Ok blood group)	Homo sapiens	97-102
26782265-5	2016	The results showed that NS-398-induced the expression of CD147 and MMP-2 via the activation of P38, which was involved in antiproliferative activity and induced pancreatic cancer cell invasiveness.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	24-30	basigin (Ok blood group)	Homo sapiens	57-62
26782265-7	2016	CD147 siRNA inhibited the invasiveness of the pancreatic cancer cells induced by NS-398, but also restored NS-398-induced antiproliferative activity.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	81-87	basigin (Ok blood group)	Homo sapiens	0-5
26782265-7	2016	CD147 siRNA inhibited the invasiveness of the pancreatic cancer cells induced by NS-398, but also restored NS-398-induced antiproliferative activity.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	107-113	basigin (Ok blood group)	Homo sapiens	0-5
26278714-9	2016	Finally, metalloproteinase activity and extracellular matrix metalloproteinase inducer (EMMPRIN) expression were inhibited and tumor cell invasion was strongly reduced in the SK-Ch-A1 cell line after treatment with EGCG and IIF.	epigallocatechin gallate	215-219	basigin (Ok blood group)	Homo sapiens	40-86
26278714-9	2016	Finally, metalloproteinase activity and extracellular matrix metalloproteinase inducer (EMMPRIN) expression were inhibited and tumor cell invasion was strongly reduced in the SK-Ch-A1 cell line after treatment with EGCG and IIF.	epigallocatechin gallate	215-219	basigin (Ok blood group)	Homo sapiens	88-95
26639052-3	2015	alpha-Hed-CS-CD147-NPs were round and spherical in shape, with an average particle size of 148.23 +- 1.75 nm.	alpha-hed-cs	0-12	basigin (Ok blood group)	Homo sapiens	13-18
26639052-4	2015	The half-maximum inhibiting concentration (IC50) of alpha-Hed-CS-CD147-NPs in human liver cancer cell lines HepG2 and SMMC-7721 was lower than that of free alpha-Hed and alpha-Hed-CS-NPs.	alpha-hed-cs	52-64	basigin (Ok blood group)	Homo sapiens	65-70
26639052-4	2015	The half-maximum inhibiting concentration (IC50) of alpha-Hed-CS-CD147-NPs in human liver cancer cell lines HepG2 and SMMC-7721 was lower than that of free alpha-Hed and alpha-Hed-CS-NPs.	smmc	118-122	basigin (Ok blood group)	Homo sapiens	65-70
26639052-6	2015	The increase in intracellular accumulation of alpha-Hed-CS-CD147-NPs was also related to CD147-mediated internalization through the Caveolae-dependent pathway and lysosomal escape.	alpha-hed-cs	46-58	basigin (Ok blood group)	Homo sapiens	59-64
26639052-6	2015	The increase in intracellular accumulation of alpha-Hed-CS-CD147-NPs was also related to CD147-mediated internalization through the Caveolae-dependent pathway and lysosomal escape.	alpha-hed-cs	46-58	basigin (Ok blood group)	Homo sapiens	89-94
26356761-0	2015	Icaritin inhibits the invasion and epithelial-to-mesenchymal transition of glioblastoma cells by targeting EMMPRIN via PTEN/AKt/HIF-1alpha signalling.	icaritin	0-8	basigin (Ok blood group)	Homo sapiens	107-114
26634540-5	2015	The effect of EMMPRIN on cell proliferation ability was detected using the MTT assay and clone formation experiments.	monooxyethylene trimethylolpropane tristearate	75-78	basigin (Ok blood group)	Homo sapiens	14-21
26356761-4	2015	The results showed that icaritin significantly inhibited the invasion and EMT of GBM cells by targeting extracellular matrix metalloproteinase (EMMPRIN).	icaritin	24-32	basigin (Ok blood group)	Homo sapiens	104-142
26356761-4	2015	The results showed that icaritin significantly inhibited the invasion and EMT of GBM cells by targeting extracellular matrix metalloproteinase (EMMPRIN).	icaritin	24-32	basigin (Ok blood group)	Homo sapiens	144-151
26356761-5	2015	Furthermore, the findings strongly indicate that the modulatory effect of icaritin on EMMPRIN is mediated via the PTEN/Akt/HIF-1alpha signalling pathway.	icaritin	74-82	basigin (Ok blood group)	Homo sapiens	86-93
26282231-0	2015	CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARalpha pathways.	Fatty Acids	17-27	basigin (Ok blood group)	Homo sapiens	0-5
26282231-1	2015	BACKGROUND & AIMS: CD147 is a transmembrane glycoprotein which is highly expressed in various human cancers including hepatocellular carcinoma (HCC).	Adenosine Monophosphate	12-15	basigin (Ok blood group)	Homo sapiens	23-28
26282231-2	2015	A drug Licartin developed with (131)Iodine-labeled antibody against CD147 has been approved by the Chinese Food and Drug Administration (FDA) and enters into clinical use for HCC treatment.	Iodine	36-42	basigin (Ok blood group)	Homo sapiens	68-73
26282231-6	2015	RESULTS: Bioinformatic analysis and experimental evidence demonstrated that CD147 significantly contributed to the reprogramming of fatty acid metabolism in HCC cells mainly through two mechanisms.	Fatty Acids	132-142	basigin (Ok blood group)	Homo sapiens	76-81
26282231-8	2015	On the other hand, CD147 downregulated peroxisome proliferator-activated receptor alpha (PPARalpha) and its transcriptional target genes CPT1A and ACOX1 by activating the p38 MAPK signaling pathway to inhibit fatty acid beta-oxidation.	Fatty Acids	209-219	basigin (Ok blood group)	Homo sapiens	19-24
26503955-4	2015	Using nanoelectrospray ionization mass spectrometry, we identify the metabolic activation related protein complex of CD147-CD98 as a major carrier of poly-N-acetyl-lactosamine (SC-PNAL) on human pre-B cell line Nalm-6.	poly-N-acetyllactosamine	150-175	basigin (Ok blood group)	Homo sapiens	117-122
26282231-9	2015	Moreover, in vitro and in vivo assays indicated that the CD147-mediated reprogramming of fatty acid metabolism played a critical role in the proliferation and metastasis of HCC cells.	Fatty Acids	89-99	basigin (Ok blood group)	Homo sapiens	57-62
26282231-10	2015	CONCLUSION: Our findings demonstrate that CD147 is a critical regulator of fatty acid metabolism, which provides a strong line of evidence for this molecule to be used as a drug target in cancer treatment.	Fatty Acids	75-85	basigin (Ok blood group)	Homo sapiens	42-47
25862460-0	2015	MiR-492 is functionally involved in Oxaliplatin resistance in colon cancer cells LS174T via its regulating the expression of CD147.	Oxaliplatin	36-47	basigin (Ok blood group)	Homo sapiens	125-130
26119672-0	2015	Emmprin Expression Predicts Response and Survival following Cisplatin Containing Chemotherapy for Bladder Cancer: A Validation Study.	Cisplatin	60-69	basigin (Ok blood group)	Homo sapiens	0-7
25838264-1	2015	BACKGROUND: Plasmodium falciparum invades human erythrocytes by using an array of ligands that interact with several receptors, including sialic acid (SA), complement receptor 1 (CR1), and basigin.	N-Acetylneuraminic Acid	151-153	basigin (Ok blood group)	Homo sapiens	189-196
25838264-8	2015	CR1 was a major mediator of SA-independent invasion, while basigin was essential for both SA-dependent and SA-independent invasion mechanisms.	N-Acetylneuraminic Acid	90-92	basigin (Ok blood group)	Homo sapiens	59-66
25838264-8	2015	CR1 was a major mediator of SA-independent invasion, while basigin was essential for both SA-dependent and SA-independent invasion mechanisms.	N-Acetylneuraminic Acid	90-92	basigin (Ok blood group)	Homo sapiens	59-66
26316167-8	2015	Knockdown of CD147 increased the chemosensitivity of CSC-like cells to gemcitabine, cisplatin, docetaxel at 0.1, 1 and 10 microM respectively, however, there was no significant difference among the three groups to paclitaxel at 10 microM.	gemcitabine	71-82	basigin (Ok blood group)	Homo sapiens	13-18
26316167-8	2015	Knockdown of CD147 increased the chemosensitivity of CSC-like cells to gemcitabine, cisplatin, docetaxel at 0.1, 1 and 10 microM respectively, however, there was no significant difference among the three groups to paclitaxel at 10 microM.	Cisplatin	84-93	basigin (Ok blood group)	Homo sapiens	13-18
26316167-8	2015	Knockdown of CD147 increased the chemosensitivity of CSC-like cells to gemcitabine, cisplatin, docetaxel at 0.1, 1 and 10 microM respectively, however, there was no significant difference among the three groups to paclitaxel at 10 microM.	Docetaxel	95-104	basigin (Ok blood group)	Homo sapiens	13-18
26316167-8	2015	Knockdown of CD147 increased the chemosensitivity of CSC-like cells to gemcitabine, cisplatin, docetaxel at 0.1, 1 and 10 microM respectively, however, there was no significant difference among the three groups to paclitaxel at 10 microM.	Paclitaxel	214-224	basigin (Ok blood group)	Homo sapiens	13-18
25704985-0	2015	Dynamic contrast-enhanced MRI evaluates the early response of human head and neck tumor xenografts following anti-EMMPRIN therapy with cisplatin or irradiation.	Cisplatin	135-144	basigin (Ok blood group)	Homo sapiens	114-121
26284589-0	2015	Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction.	Lactic Acid	44-51	basigin (Ok blood group)	Homo sapiens	17-24
26284589-0	2015	Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction.	Lactic Acid	44-51	basigin (Ok blood group)	Homo sapiens	25-30
26284589-2	2015	BASIGIN controls tumour metabolism, particularly glycolysis by facilitating lactic acid export through the two monocarboxylate transporters MCT1 and hypoxia-inducible MCT4.	Lactic Acid	76-87	basigin (Ok blood group)	Homo sapiens	0-7
25980581-6	2015	Compared with the control, ING5 transfectants displayed drug resistance to triciribine, paclitaxel, cisplatin, SAHA, MG132 and parthenolide, which was positively related to their apoptotic induction and the overexpression of chemoresistance-related genes (MDR1, GRP78, GRP94, IRE, CD147, FBXW7, TOP1, TOP2, MLH1, MRP1, BRCP1 and GST-pi).	parthenolide	127-139	basigin (Ok blood group)	Homo sapiens	281-286
26050197-3	2015	After treated with cisplatin, MG132, paclitaxel and SAHA, both BTG1 transfectants showed lower mRNA viability and higher apoptosis than the control in both time- and dose-dependent manners (p < 0.05) with the hypoexpression of chemoresistance-related genes (slug, CD147, GRP78, GRP94, FBXW7 TOP1, TOP2 and GST-pi).	Vorinostat	52-56	basigin (Ok blood group)	Homo sapiens	267-272
26146069-2	2015	METHODS: CD147 expression data were derived by Robust Multi-array Averaging method from three different microarrays, GSE14308, GSE36765 and GSE6532.	gse6532	140-147	basigin (Ok blood group)	Homo sapiens	9-14
27832636-0	2016	Inhibition of EMMPRIN and MMP-9 Expression by Epigallocatechin-3-Gallate through 67-kDa Laminin Receptor in PMA-Induced Macrophages.	epigallocatechin gallate	46-72	basigin (Ok blood group)	Homo sapiens	14-21
27832636-4	2016	The aim of the present study was to evaluate the effects of EGCG on the expression of EMMPRIN and MMP-9 in PMA-induced macrophages, and the potential mechanisms underlying its effects.	epigallocatechin gallate	60-64	basigin (Ok blood group)	Homo sapiens	86-93
27832636-8	2016	RESULTS: We showed that EGCG (10-50micromol/L) significantly inhibited the expression of EMMPRIN and MMP-9 and activation of extracellular signal-regulated kinase 1/2 (ERK1/2), p38 and c-Jun N-terminal kinase (JNK) in PMA-induced macrophages.	epigallocatechin gallate	24-28	basigin (Ok blood group)	Homo sapiens	89-96
27832636-9	2016	Downregulation of EMMPRIN by gene silencing hindered PMA-induced MMP-9 secretion and expression, indicating an important role of EMMPRIN in the inhibition of MMP-9 by EGCG.	epigallocatechin gallate	167-171	basigin (Ok blood group)	Homo sapiens	18-25
27832636-9	2016	Downregulation of EMMPRIN by gene silencing hindered PMA-induced MMP-9 secretion and expression, indicating an important role of EMMPRIN in the inhibition of MMP-9 by EGCG.	epigallocatechin gallate	167-171	basigin (Ok blood group)	Homo sapiens	129-136
27832636-10	2016	Moreover, 67LR was involved in EGCG-mediated suppression of EMMPRIN and MMP-9 expression.	epigallocatechin gallate	31-35	basigin (Ok blood group)	Homo sapiens	60-67
27832636-11	2016	Anti-67LR antibody treatment led to abrogation of the inhibitory action of EGCG on the expression of EMMPRIN and MMP-9 and activation of ERK1/2, p38, and JNK.	epigallocatechin gallate	75-79	basigin (Ok blood group)	Homo sapiens	101-108
27832636-12	2016	CONCLUSION: Our results indicate that EGCG restrains EMMPRIN and MMP-9 expression via 67LR in PMA-induced macrophages, which also suggests that EGCG may be a possible therapeutic agent for stabilizing atherosclerotic plaque.	epigallocatechin gallate	38-42	basigin (Ok blood group)	Homo sapiens	53-60
27832636-12	2016	CONCLUSION: Our results indicate that EGCG restrains EMMPRIN and MMP-9 expression via 67LR in PMA-induced macrophages, which also suggests that EGCG may be a possible therapeutic agent for stabilizing atherosclerotic plaque.	epigallocatechin gallate	144-148	basigin (Ok blood group)	Homo sapiens	53-60
26530384-6	2015	The interaction of CD147 with rEtpE-C was validated by far-Western blotting and coimmunoprecipitation of native EtpE with endogenous CD147.	retpe-c	30-37	basigin (Ok blood group)	Homo sapiens	19-24
26530384-6	2015	The interaction of CD147 with rEtpE-C was validated by far-Western blotting and coimmunoprecipitation of native EtpE with endogenous CD147.	retpe-c	30-37	basigin (Ok blood group)	Homo sapiens	133-138
25196575-11	2015	EMMPRIN also increased in proportion with the ratio of L- to D-lactic acid in controls and in women with BV (P <= 0.009).	Lactic Acid	63-74	basigin (Ok blood group)	Homo sapiens	0-7
25263481-0	2015	CD147 and MCT1-potential partners in bladder cancer aggressiveness and cisplatin resistance.	Cisplatin	71-80	basigin (Ok blood group)	Homo sapiens	0-5
25263481-8	2015	Moreover, when selecting patients who received platinum-based chemotherapy, the prognosis was significantly worse for those with MCT1 and CD147 positive tumors.	Platinum	47-55	basigin (Ok blood group)	Homo sapiens	138-143
25263481-9	2015	CD147 specific silencing by small interfering RNAs (siRNAs) in UBC cells was accompanied by a decrease in MCT1 and MCT4 expressions and, importantly, an increase in chemosensitivity to cisplatin.	Cisplatin	185-194	basigin (Ok blood group)	Homo sapiens	0-5
25263481-10	2015	Our results provide novel insights for the involvement of CD147 and MCTs in bladder cancer progression and resistance to cisplatin-based chemotherapy.	Cisplatin	121-130	basigin (Ok blood group)	Homo sapiens	58-63
25263481-11	2015	We consider that the possible cooperative role of CD147 and MCT1 in determining cisplatin resistance should be further explored as a potential theranostics biomarker.	Cisplatin	80-89	basigin (Ok blood group)	Homo sapiens	50-55
26507719-8	2015	Immunofluorescence double staining confirmed the co-localization of CD147 and MMP-11 in paraffin-embedded tissues of CRC patients.	Paraffin	88-96	basigin (Ok blood group)	Homo sapiens	68-73
26617699-7	2015	In addition, the regulated expression of GnT-V in the CNE-2R cells converted the heterogeneous N-glycosylated forms of CD147.	Nitrogen	55-56	basigin (Ok blood group)	Homo sapiens	119-124
25862460-10	2015	These findings provide direct evidences that the miR-492/CD147 axis might play an essential role in the Oxaliplatin resistance of colon cancer cells, suggesting that the miR-492/CD147 signaling cohort could be served as a novel therapeutic target for the treatment of chemotherapy resistant in colon cancer.	Oxaliplatin	104-115	basigin (Ok blood group)	Homo sapiens	178-183
25248362-5	2015	In the CKD that follows AKI, a molecular circuit involving CD147, MMPs and transforming growth factor-beta may be involved in the pathogenesis of progressive fibrosis through hyaluronan production and macrophage infiltration.	Hyaluronic Acid	175-185	basigin (Ok blood group)	Homo sapiens	59-64
25862460-6	2015	In the present study, we found that lower level of miR-492 is accompanied with increased expression of CD147 in Oxaliplatin-resistant colon cancer cell line LS174T/L-OHP as compared with its parental cell line LS174T.	Oxaliplatin	112-123	basigin (Ok blood group)	Homo sapiens	103-108
25862460-7	2015	Exogenous expression of miR-492 in LS174T/L-OHP could sensitize its reaction on the treatment of Oxaliplatin, which is coincided with its directly reducing the expression of CD147.	Oxaliplatin	97-108	basigin (Ok blood group)	Homo sapiens	174-179
25862460-8	2015	Furthermore, we found that knockdown of CD147 in LS174T/L-OHP could also sensitize its reaction of the treatment with Oxaliplatin.	Oxaliplatin	118-129	basigin (Ok blood group)	Homo sapiens	40-45
25862460-10	2015	These findings provide direct evidences that the miR-492/CD147 axis might play an essential role in the Oxaliplatin resistance of colon cancer cells, suggesting that the miR-492/CD147 signaling cohort could be served as a novel therapeutic target for the treatment of chemotherapy resistant in colon cancer.	Oxaliplatin	104-115	basigin (Ok blood group)	Homo sapiens	57-62
25503107-7	2015	Anti-EMMPRIN strategies, such as MV deglycosylation, gene knockdown, and specific blocking peptides, inhibit MV-induced invasion.	methyluridine-5-oxyacetic acid	33-35	basigin (Ok blood group)	Homo sapiens	5-12
25510296-6	2015	CD147 protein expression in the renal tubules showed a negative correlation with estimated glomerular filtration rate (eGFR; r = -0.600, P = 0.000) and a positive correlation with serum creatinine (Scr; r = 0.322, P = 0.002) and tubulointerstitial lesions (r = 0.525, P = 0.000).	Creatinine	186-196	basigin (Ok blood group)	Homo sapiens	0-5
26054676-10	2015	Our study for the first time demonstrated that miR-485-5p represses HCC invasive and metastatic capacities by targeting EMMPRIN expression.	CHEMBL3740941	55-57	basigin (Ok blood group)	Homo sapiens	120-127
25813864-5	2015	Additionally, the treatment of methylated cell lines with 5-aza-2"-deoxycytidine increased CD147 expression significantly in low-expressing cell lines and also activated the expression of matrix metalloproteinase (MMP)-2, which may be one of the most important downstream targets of CD147.	Decitabine	58-80	basigin (Ok blood group)	Homo sapiens	91-96
25813864-5	2015	Additionally, the treatment of methylated cell lines with 5-aza-2"-deoxycytidine increased CD147 expression significantly in low-expressing cell lines and also activated the expression of matrix metalloproteinase (MMP)-2, which may be one of the most important downstream targets of CD147.	Decitabine	58-80	basigin (Ok blood group)	Homo sapiens	283-288
25625234-0	2015	Ara-C increases gastric cancer cell invasion by upregulating CD-147-MMP-2/MMP-9 via the ERK signaling pathway.	Cytarabine	0-5	basigin (Ok blood group)	Homo sapiens	61-67
25625234-8	2015	Although low-dose Ara-C had no obvious effect on cell proliferation, it upregulated the expression of MMP-2, MMP-9 and CD-147 and ERK activation.	Cytarabine	18-23	basigin (Ok blood group)	Homo sapiens	119-125
25625234-10	2015	U-0126 and siRNA-CD-147 inhibited the induction of Ara-C in gastric cancer cell invasion.	Cytarabine	51-56	basigin (Ok blood group)	Homo sapiens	17-23
25625234-11	2015	Therefore, Ara-C enhances the invasiveness of gastric cancer cells by expression of CD-147 /MMP-2 and MMP-9 via the ERK signaling pathway.	Cytarabine	11-16	basigin (Ok blood group)	Homo sapiens	84-90
24832574-9	2015	IOBA-NHC cells exposed to BAK presented a significant increase in EMMPRIN, which was proportional to the concentration of BAK.	Benzalkonium Compounds	26-29	basigin (Ok blood group)	Homo sapiens	66-73
25308857-7	2015	Moreover, knockout of HAb18G/CD147 expression also induced SMMC-K7721 cells to undergo apoptosis compared to SMMC-7721 and SMMC-R7721 (P < 0.01).	smmc	59-63	basigin (Ok blood group)	Homo sapiens	29-34
25658763-5	2015	RESULTS: 1) It was mainly the highly-glycosylated form of EMMPRIN (HG-EMMPRIN) that increased after being exposed to inflammatory signals (PMA and H2O2).	Tetradecanoylphorbol Acetate	139-142	basigin (Ok blood group)	Homo sapiens	58-65
25658763-5	2015	RESULTS: 1) It was mainly the highly-glycosylated form of EMMPRIN (HG-EMMPRIN) that increased after being exposed to inflammatory signals (PMA and H2O2).	Tetradecanoylphorbol Acetate	139-142	basigin (Ok blood group)	Homo sapiens	70-77
25658763-5	2015	RESULTS: 1) It was mainly the highly-glycosylated form of EMMPRIN (HG-EMMPRIN) that increased after being exposed to inflammatory signals (PMA and H2O2).	Hydrogen Peroxide	147-151	basigin (Ok blood group)	Homo sapiens	58-65
25658763-5	2015	RESULTS: 1) It was mainly the highly-glycosylated form of EMMPRIN (HG-EMMPRIN) that increased after being exposed to inflammatory signals (PMA and H2O2).	Hydrogen Peroxide	147-151	basigin (Ok blood group)	Homo sapiens	70-77
25658763-6	2015	2) Glycosylation of EMMPRIN in monocytes/macrophages led to N-linked-glycans being added to the protein, with the HG form containing complex-type glycans and the less-glycosylated form (LG) the simple type.	n-linked-glycans	60-76	basigin (Ok blood group)	Homo sapiens	20-27
25658763-6	2015	2) Glycosylation of EMMPRIN in monocytes/macrophages led to N-linked-glycans being added to the protein, with the HG form containing complex-type glycans and the less-glycosylated form (LG) the simple type.	Polysaccharides	69-76	basigin (Ok blood group)	Homo sapiens	20-27
25260396-0	2015	shRNA-mediated EMMPRIN silencing inhibits human leukemic monocyte lymphoma U937 cell proliferation and increases chemosensitivity to adriamycin.	Doxorubicin	133-143	basigin (Ok blood group)	Homo sapiens	15-22
25260396-12	2015	This study also showed that silencing of EMMPRIN sensitized U937 cells to Adriamycin.	Doxorubicin	74-84	basigin (Ok blood group)	Homo sapiens	41-48
24832574-9	2015	IOBA-NHC cells exposed to BAK presented a significant increase in EMMPRIN, which was proportional to the concentration of BAK.	Benzalkonium Compounds	122-125	basigin (Ok blood group)	Homo sapiens	66-73
24832574-11	2015	CONCLUSIONS: The increased expression of EMMPRIN in patients topically treated with multiple antiglaucoma BAK-preserved eye drops suggests a matrix metalloproteinase-related modification of conjunctival ECM remodeling.	Benzalkonium Compounds	106-109	basigin (Ok blood group)	Homo sapiens	41-48
24832574-12	2015	In vitro results suggest that CsA has the potential to limit BAK effects on EMMPRIN.	Benzalkonium Compounds	61-64	basigin (Ok blood group)	Homo sapiens	76-83
25755717-3	2015	CD147 play a crucial role in tumorigenicity, invasion and metastasis; and CD147 also interacts strongly and specifically with monocarboxylate transporter1 (MCT1) that mediates the transport of lactate.	Lactic Acid	193-200	basigin (Ok blood group)	Homo sapiens	0-5
25456395-3	2015	Lactate transport through monocarboxylate transporters (MCTs) and the chaperone CD147 is essential for high glycolytic cancer cell survival.	Lactic Acid	0-7	basigin (Ok blood group)	Homo sapiens	80-85
25755717-3	2015	CD147 play a crucial role in tumorigenicity, invasion and metastasis; and CD147 also interacts strongly and specifically with monocarboxylate transporter1 (MCT1) that mediates the transport of lactate.	Lactic Acid	193-200	basigin (Ok blood group)	Homo sapiens	74-79
25755717-4	2015	The objective of this study was to determine whether CD147 is involved, via its association with MCT1 to transport lactate, in glycolysis, contributing to the progression of thyroid carcinoma.	Lactic Acid	115-122	basigin (Ok blood group)	Homo sapiens	53-58
25310356-9	2014	In conclusion, the findings of the present study suggest that the combined use of rapamycin and berberine may improve HCC therapy through synergistically inhibiting the mTOR signaling pathway, which is at least in part, mediated through CD147.	Berberine	96-105	basigin (Ok blood group)	Homo sapiens	237-242
25053832-0	2014	CD147 up-regulates calcium-induced chemotaxis, adhesion ability and invasiveness of human neutrophils via a TRPM-7-mediated mechanism.	Calcium	19-26	basigin (Ok blood group)	Homo sapiens	0-5
25550778-6	2014	CD147 overexpression increased the 5-Fluorouracil (5-FU) resistance, enhanced the invasion and EMT of CRC cells by regulating EMT markers and MMPs.	Fluorouracil	35-49	basigin (Ok blood group)	Homo sapiens	0-5
25403912-0	2015	Genetic disruption of lactate/H+ symporters (MCTs) and their subunit CD147/BASIGIN sensitizes glycolytic tumor cells to phenformin.	Phenformin	120-130	basigin (Ok blood group)	Homo sapiens	69-74
25403912-0	2015	Genetic disruption of lactate/H+ symporters (MCTs) and their subunit CD147/BASIGIN sensitizes glycolytic tumor cells to phenformin.	Phenformin	120-130	basigin (Ok blood group)	Homo sapiens	75-82
25403912-2	2015	To further explore and validate the blockade of lactic acid export as an anticancer strategy, we disrupted, via zinc finger nucleases, MCT4 and BASIGIN genes in colon adenocarcinoma (LS174T) and glioblastoma (U87) human cell lines.	Lactic Acid	48-59	basigin (Ok blood group)	Homo sapiens	144-151
25403912-4	2015	Second, we demonstrated that knockout of BSG leads to a decrease in lactate transport activity of MCT1 and MCT4 by 10- and 6-fold, respectively.	Lactic Acid	68-75	basigin (Ok blood group)	Homo sapiens	41-44
25403912-7	2015	Third, we showed that in contrast with parental cells, BSG-null cells became highly sensitive to phenformin, an inhibitor of mitochondrial complex I.	Phenformin	97-107	basigin (Ok blood group)	Homo sapiens	55-58
25053832-5	2014	RESULTS: CD147 up-regulates the calcium-induced chemotaxis, adhesion ability and invasiveness of human neutrophils in RA patients.	Calcium	32-39	basigin (Ok blood group)	Homo sapiens	9-14
25053832-7	2014	CONCLUSION: These findings suggest that in RA patients, abundant CypA up-regulates the calcium-induced chemotactic, adhesive and invasive properties of neutrophils via direct binding to CD147.	Calcium	87-94	basigin (Ok blood group)	Homo sapiens	186-191
24801417-8	2014	CD147 facilitated the cell surface expression of MCT1 and lactate export, which led to activation of the PI3K/Akt/MDM2 pathway and thus increased p53 degradation.	Lactic Acid	58-65	basigin (Ok blood group)	Homo sapiens	0-5
24166504-6	2014	Indeed, we found that the stabilization of MCT1 and CD147 proteins upon glucose removal depends on mitochondrial impairment and the associated generation of reactive oxygen species.	Reactive Oxygen Species	157-180	basigin (Ok blood group)	Homo sapiens	52-57
25550778-6	2014	CD147 overexpression increased the 5-Fluorouracil (5-FU) resistance, enhanced the invasion and EMT of CRC cells by regulating EMT markers and MMPs.	Fluorouracil	51-55	basigin (Ok blood group)	Homo sapiens	0-5
25550778-8	2014	Further investigation revealed that CD147 activated MAPK/ERK pathway, ERK inhibitor U0126 suppressed the CD147-induced cell invasion, migration and MMP-2, MMP-9 expression.	U 0126	84-89	basigin (Ok blood group)	Homo sapiens	36-41
25550778-8	2014	Further investigation revealed that CD147 activated MAPK/ERK pathway, ERK inhibitor U0126 suppressed the CD147-induced cell invasion, migration and MMP-2, MMP-9 expression.	U 0126	84-89	basigin (Ok blood group)	Homo sapiens	105-110
25550778-9	2014	Taken together, our study indicates that CD147 promotes the 5-FU resistance, and MAPK/ERK signaling pathway is involved in CD147-promoted invasion and EMT of CRC cells.	Fluorouracil	60-64	basigin (Ok blood group)	Homo sapiens	41-46
25241044-0	2014	Curcumin inhibits EMMPRIN and MMP-9 expression through AMPK-MAPK and PKC signaling in PMA induced macrophages.	Curcumin	0-8	basigin (Ok blood group)	Homo sapiens	18-25
25241044-4	2014	The purpose of our study was to investigate the molecular mechanisms by which curcumin affects MMP-9, MMP13 and EMMPRIN in PMA (phorbol 12-myristate 13-acetate) induced macrophages.	Curcumin	78-86	basigin (Ok blood group)	Homo sapiens	112-119
25241044-4	2014	The purpose of our study was to investigate the molecular mechanisms by which curcumin affects MMP-9, MMP13 and EMMPRIN in PMA (phorbol 12-myristate 13-acetate) induced macrophages.	Tetradecanoylphorbol Acetate	128-159	basigin (Ok blood group)	Homo sapiens	112-119
25241044-6	2014	In the present study, the exposure to curcumin resulted in attenuated JNK, p38, and ERK activation and decreased expression of MMP-9, MMP-13 and EMMPRIN in PMA induced macrophages.	Curcumin	38-46	basigin (Ok blood group)	Homo sapiens	145-152
25241044-8	2014	Furthermore, curcumin reversed PMA stimulated PKC activation and suppressed the chronic activation of AMPK, which in turn reduced the expression of MMP-9, MMP-13 and EMMPRIN.	Curcumin	13-21	basigin (Ok blood group)	Homo sapiens	166-173
25241044-8	2014	Furthermore, curcumin reversed PMA stimulated PKC activation and suppressed the chronic activation of AMPK, which in turn reduced the expression of MMP-9, MMP-13 and EMMPRIN.	Tetradecanoylphorbol Acetate	31-34	basigin (Ok blood group)	Homo sapiens	166-173
25241044-9	2014	Therefore, it is suggested that curcumin by inhibiting AMPK-MAPK (mitogen activated protein kinase) and PKC pathway may led to down-regulated EMMPRIN, MMP-9 and MMP-13 expression in PMA-induced THP-1 cells.	Curcumin	32-40	basigin (Ok blood group)	Homo sapiens	142-149
24970053-4	2014	CD147 is a major carrier of beta1-6-branched polylactosamine sugars on tumor cells, and the high glycoform of CD147 (HG-CD147) induces matrix metalloproteinase (MMP) production.	beta1-6-branched polylactosamine sugars	28-67	basigin (Ok blood group)	Homo sapiens	0-5
24970053-4	2014	CD147 is a major carrier of beta1-6-branched polylactosamine sugars on tumor cells, and the high glycoform of CD147 (HG-CD147) induces matrix metalloproteinase (MMP) production.	beta1-6-branched polylactosamine sugars	28-67	basigin (Ok blood group)	Homo sapiens	117-125
24970053-9	2014	Hence, various concentrations of tunicamycin were used to treat the cells in order to study its influence on CD147 N-glycosylation and MMP-2 expression.	Tunicamycin	33-44	basigin (Ok blood group)	Homo sapiens	109-114
24970053-9	2014	Hence, various concentrations of tunicamycin were used to treat the cells in order to study its influence on CD147 N-glycosylation and MMP-2 expression.	Nitrogen	115-116	basigin (Ok blood group)	Homo sapiens	109-114
24970053-10	2014	In conclusion, we found that beta3GnT8 regulated the level of N-glycans on CD147 and that N-glycosylation of CD147 has an important effect on MMP-2 expression.	n-glycans	62-71	basigin (Ok blood group)	Homo sapiens	75-80
24970053-10	2014	In conclusion, we found that beta3GnT8 regulated the level of N-glycans on CD147 and that N-glycosylation of CD147 has an important effect on MMP-2 expression.	Nitrogen	62-63	basigin (Ok blood group)	Homo sapiens	75-80
24970053-11	2014	Our findings suggest that beta3GnT8 affects the signal transduction pathway of MMP-2 by altering the N-glycan structure of CD147.	n-glycan	101-109	basigin (Ok blood group)	Homo sapiens	123-128
25116803-8	2014	alpha-Solanine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK), and tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2.	alpha-solanine	0-14	basigin (Ok blood group)	Homo sapiens	138-145
24584970-13	2014	For example, glutamate at several concentrations induces or enhances significantly very important functions of human T-leukemia and T-lymphoma cells, among them adhesion to the extracellular matrix, migration, in vivo engraftment into solid organs, and the production and secretion of the cancer-associated matrix metalloproteinase MMP-9 and its inducer CD147.	Glutamic Acid	13-22	basigin (Ok blood group)	Homo sapiens	354-359
24166504-7	2014	When glucose was a limited resource (a situation occurring naturally or during the treatment of many tumors), MCT1-CD147 heterocomplexes accumulated, including in cell protrusions of the plasma membrane.	Glucose	5-12	basigin (Ok blood group)	Homo sapiens	115-120
24573103-10	2014	HG-CD147 is a major carrier of beta1,6-branched polylactosamine sugars; therefore, the regulation of beta3GnT8 significantly altered the beta1,6-branched polylactosamine structures on CD147.	beta1,6-branched polylactosamine sugars	31-70	basigin (Ok blood group)	Homo sapiens	3-8
26202642-10	2014	Silencing of CD147 significantly inhibited the glycolytic rate and induced apoptosis in SMMC-7721 cells.	smmc	88-92	basigin (Ok blood group)	Homo sapiens	13-18
24857275-1	2014	OBJECTIVE: To investigate the prognostic significance of lactate/proton monocarboxylate transporters MCT1, MCT4, and their chaperone CD147 expressions in urothelial carcinoma of the bladder (UCB).	Lactic Acid	57-64	basigin (Ok blood group)	Homo sapiens	133-138
24857275-4	2014	RESULTS: MCT1, MCT4, and CD147 expressions were increased in 130 (36.1%), 168 (46.7%), and 228 (63.3%) UCB cases, respectively.	ucb	103-106	basigin (Ok blood group)	Homo sapiens	25-30
25015330-8	2014	Lastly, MVs obtained from CD147 downregulated HMCLs were attenuated in their ability to stimulate HMCL proliferation.	hmcls	46-51	basigin (Ok blood group)	Homo sapiens	26-31
25033086-9	2014	Furthermore, the current data showed that CD147 reduced tyrosine phosphorylation in vinculin-mediated focal adhesions, and enhanced the accumulation of the acidic phospholipid phosphatidylinositol-4, 5-bisphosphate (PIP2).	Tyrosine	56-64	basigin (Ok blood group)	Homo sapiens	42-47
25033086-9	2014	Furthermore, the current data showed that CD147 reduced tyrosine phosphorylation in vinculin-mediated focal adhesions, and enhanced the accumulation of the acidic phospholipid phosphatidylinositol-4, 5-bisphosphate (PIP2).	phospholipid phosphatidylinositol-4, 5-bisphosphate	163-214	basigin (Ok blood group)	Homo sapiens	42-47
25033086-9	2014	Furthermore, the current data showed that CD147 reduced tyrosine phosphorylation in vinculin-mediated focal adhesions, and enhanced the accumulation of the acidic phospholipid phosphatidylinositol-4, 5-bisphosphate (PIP2).	Phosphatidylinositol 4,5-Diphosphate	216-220	basigin (Ok blood group)	Homo sapiens	42-47
24573103-10	2014	HG-CD147 is a major carrier of beta1,6-branched polylactosamine sugars; therefore, the regulation of beta3GnT8 significantly altered the beta1,6-branched polylactosamine structures on CD147.	beta1,6-branched polylactosamine	31-63	basigin (Ok blood group)	Homo sapiens	3-8
24573103-11	2014	Hence, we suggest that beta3GnT8 plays a key role in the metastasis of colorectal cancer cells by altering the beta1,6-branched polylactosamine sugars of CD147.	beta1,6-branched polylactosamine	111-143	basigin (Ok blood group)	Homo sapiens	154-159
24573103-11	2014	Hence, we suggest that beta3GnT8 plays a key role in the metastasis of colorectal cancer cells by altering the beta1,6-branched polylactosamine sugars of CD147.	Sugars	144-150	basigin (Ok blood group)	Homo sapiens	154-159
25081536-0	2014	CD147: regulator of hyaluronan signaling in invasiveness and chemoresistance.	Hyaluronic Acid	20-30	basigin (Ok blood group)	Homo sapiens	0-5
24505326-6	2014	The expression of MMP-2/9, extracellular inducer of matrix metalloproteinase (EMMPRIN), CD44, eNOS and E-cadherin were suppressed by alpha-solanine in PANC-1 cells.	alpha-solanine	133-147	basigin (Ok blood group)	Homo sapiens	78-85
24739808-6	2014	Here, we review current understanding of the glycosylation characteristics of CD147 and the glycosyltransferases involved in the biosynthesis of CD147 N-glycans.	n-glycans	151-160	basigin (Ok blood group)	Homo sapiens	78-83
24739808-6	2014	Here, we review current understanding of the glycosylation characteristics of CD147 and the glycosyltransferases involved in the biosynthesis of CD147 N-glycans.	n-glycans	151-160	basigin (Ok blood group)	Homo sapiens	145-150
24967412-10	2014	The independent value of EMMPRIN overexpression in CSS suggests that this protein could be used as an important biological prognostic marker for patients with OSCC.	thiocysteine	51-54	basigin (Ok blood group)	Homo sapiens	25-32
25470292-8	2014	We also showed that CD147 increased the viability of A375 cells exposed to berberine-induced mitochondrial damage, and protected them from apoptosis through a mitochondrial-dependent pathway.	Berberine	75-84	basigin (Ok blood group)	Homo sapiens	20-25
24217276-0	2014	Is cholesterol and amyloid-beta stress induced CD147 expression a protective response?	Cholesterol	3-14	basigin (Ok blood group)	Homo sapiens	47-52
24217276-4	2014	Given that high fat/cholesterol is linked to amyloid deposition in AD, we investigated if cholesterol and/or Abeta can alter CD147 expression in rat cortical neuronal cultures.	Cholesterol	90-101	basigin (Ok blood group)	Homo sapiens	125-130
24217276-4	2014	Given that high fat/cholesterol is linked to amyloid deposition in AD, we investigated if cholesterol and/or Abeta can alter CD147 expression in rat cortical neuronal cultures.	UNII-042A8N37WH	109-114	basigin (Ok blood group)	Homo sapiens	125-130
24217276-5	2014	Water-soluble cholesterol and Abeta42 dose-dependently increased CD147 protein expression, but reduced FL-AbetaPP protein expression.	Water	0-5	basigin (Ok blood group)	Homo sapiens	65-70
24217276-5	2014	Water-soluble cholesterol and Abeta42 dose-dependently increased CD147 protein expression, but reduced FL-AbetaPP protein expression.	Cholesterol	14-25	basigin (Ok blood group)	Homo sapiens	65-70
24217276-7	2014	Upregulation of CD147 expression was probably mediated by oxidative stress, as H2O2 (3 muM) also induced CD147 protein expression in neuronal cultures.	Hydrogen Peroxide	79-83	basigin (Ok blood group)	Homo sapiens	16-21
24217276-7	2014	Upregulation of CD147 expression was probably mediated by oxidative stress, as H2O2 (3 muM) also induced CD147 protein expression in neuronal cultures.	Hydrogen Peroxide	79-83	basigin (Ok blood group)	Homo sapiens	105-110
25427584-6	2014	The sorted SP cells showed high positivity with regard to CD133, CD44, CD147, and EpCAM, by fluorescence microscopic analysis.	sp	11-13	basigin (Ok blood group)	Homo sapiens	71-76
23791883-2	2013	We were able to identify CD147 expressing fractions in SCC172 OSCC cell line with differing Hoechst dye efflux activity and DNA content.	hoechst dye	92-103	basigin (Ok blood group)	Homo sapiens	25-30
24057089-2	2013	The unit was used for the solid-phase peptide synthesis (SPPS) of the N-acetylglucosaminylated emmprin (35-69) thioester via one-step deprotection by TFA combined with the N-alkylcysteine thioesterification method.	Nitrogen	70-71	basigin (Ok blood group)	Homo sapiens	95-102
24057089-2	2013	The unit was used for the solid-phase peptide synthesis (SPPS) of the N-acetylglucosaminylated emmprin (35-69) thioester via one-step deprotection by TFA combined with the N-alkylcysteine thioesterification method.	Trifluoroacetic Acid	150-153	basigin (Ok blood group)	Homo sapiens	95-102
24057089-2	2013	The unit was used for the solid-phase peptide synthesis (SPPS) of the N-acetylglucosaminylated emmprin (35-69) thioester via one-step deprotection by TFA combined with the N-alkylcysteine thioesterification method.	n-alkylcysteine	172-187	basigin (Ok blood group)	Homo sapiens	95-102
24057089-3	2013	This segment was used for the synthesis of the first Ig domain (22-104) of emmprin carrying GlcNAc by one-pot ligation with other segments using the thioester method.	2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose	92-98	basigin (Ok blood group)	Homo sapiens	75-82
23879967-0	2013	A novel interaction between calcium-modulating cyclophilin ligand and Basigin regulates calcium signaling and matrix metalloproteinase activities in human melanoma cells.	Calcium	28-35	basigin (Ok blood group)	Homo sapiens	70-77
23879967-6	2013	Knockdown of Basigin in melanoma cells by siRNA significantly decreased resting [Ca2+]i and the [Ca2+]i increase induced by the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) inhibitor thapsigargin (TG), indicating that the interaction between CAML and Basigin regulates ER-dependent [Ca2+]i signaling.	Thapsigargin	188-200	basigin (Ok blood group)	Homo sapiens	13-20
23879967-6	2013	Knockdown of Basigin in melanoma cells by siRNA significantly decreased resting [Ca2+]i and the [Ca2+]i increase induced by the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) inhibitor thapsigargin (TG), indicating that the interaction between CAML and Basigin regulates ER-dependent [Ca2+]i signaling.	Thapsigargin	202-204	basigin (Ok blood group)	Homo sapiens	13-20
23879967-7	2013	Meanwhile upregulating the [Ca2+]i either by TG or phorbol myristate acetate (PMA) could stimulate the production of MMP-9 in A375 cells with the expression of Basigin.	Thapsigargin	45-47	basigin (Ok blood group)	Homo sapiens	160-167
23879967-7	2013	Meanwhile upregulating the [Ca2+]i either by TG or phorbol myristate acetate (PMA) could stimulate the production of MMP-9 in A375 cells with the expression of Basigin.	Tetradecanoylphorbol Acetate	51-76	basigin (Ok blood group)	Homo sapiens	160-167
23879967-7	2013	Meanwhile upregulating the [Ca2+]i either by TG or phorbol myristate acetate (PMA) could stimulate the production of MMP-9 in A375 cells with the expression of Basigin.	Tetradecanoylphorbol Acetate	78-81	basigin (Ok blood group)	Homo sapiens	160-167
24266206-1	2013	This study aims to bioconjugate anti-EMMPRIN monoclonal antibody on the surface of carboxyl-SPIO nanoparticles and to optimize the activated conditions of bioconjugation.	carboxyl-spio	83-96	basigin (Ok blood group)	Homo sapiens	37-44
24266206-2	2013	Anti-EMMPRIN monoclonal antibody bioconjugated carboxyl-SPIO nanoparticles were performed through a coupling strategy of EDC and sulfo-NHS.	carboxyl-spio	47-60	basigin (Ok blood group)	Homo sapiens	5-12
24266206-2	2013	Anti-EMMPRIN monoclonal antibody bioconjugated carboxyl-SPIO nanoparticles were performed through a coupling strategy of EDC and sulfo-NHS.	ethylene dichloride	121-124	basigin (Ok blood group)	Homo sapiens	5-12
24266206-2	2013	Anti-EMMPRIN monoclonal antibody bioconjugated carboxyl-SPIO nanoparticles were performed through a coupling strategy of EDC and sulfo-NHS.	N-hydroxysulfosuccimide	129-138	basigin (Ok blood group)	Homo sapiens	5-12
24013424-0	2013	CD147 regulates the expression of MCT1 and lactate export in multiple myeloma cells.	Lactic Acid	43-50	basigin (Ok blood group)	Homo sapiens	0-5
24073208-0	2013	EMMPRIN promotes angiogenesis, proliferation, invasion and resistance to sunitinib in renal cell carcinoma, and its level predicts patient outcome.	Sunitinib	73-82	basigin (Ok blood group)	Homo sapiens	0-7
24073208-7	2013	EMMPRIN expression was evaluated in RCC patients who received sunitinib therapy and in sunitinib-resistant cells.	Sunitinib	62-71	basigin (Ok blood group)	Homo sapiens	0-7
24073208-7	2013	EMMPRIN expression was evaluated in RCC patients who received sunitinib therapy and in sunitinib-resistant cells.	Sunitinib	87-96	basigin (Ok blood group)	Homo sapiens	0-7
24073208-8	2013	Further, the relation between EMMPRIN expression and sensitivity to sunitinib was examined.	Sunitinib	68-77	basigin (Ok blood group)	Homo sapiens	30-37
24073208-12	2013	EMMPRIN expression was significantly increased in patients who received sunitinib therapy as well as in sunitinib-resistant 786-O cells (786-suni).	Sunitinib	72-81	basigin (Ok blood group)	Homo sapiens	0-7
24073208-12	2013	EMMPRIN expression was significantly increased in patients who received sunitinib therapy as well as in sunitinib-resistant 786-O cells (786-suni).	Sunitinib	104-113	basigin (Ok blood group)	Homo sapiens	0-7
24073208-13	2013	EMMPRIN-overexpressing RCC cells were resistant to sunitinib.	Sunitinib	51-60	basigin (Ok blood group)	Homo sapiens	0-7
24073208-14	2013	CONCLUSION: Our findings indicate that high expression of EMMPRIN in RCC plays important roles in tumor progression and sunitinib resistance.	Sunitinib	120-129	basigin (Ok blood group)	Homo sapiens	58-65
23888049-6	2013	Here we found that CD147 induces breast epithelial cell invasiveness by promoting epidermal growth factor receptor (EGFR)-Ras-ERK signaling in a manner dependent on hyaluronan-CD44 interaction.	Hyaluronic Acid	165-175	basigin (Ok blood group)	Homo sapiens	19-24
24284901-4	2013	The selective endosomal sorting of molecules like CD44, CD98, and CD147, which are involved in cell-cell and cell-extracellular interactions, indicates that sorting mechanisms dictate the post-endocytic fate of CIE cargo proteins.	chlorimuron ethyl	211-214	basigin (Ok blood group)	Homo sapiens	66-71
24011158-2	2013	METHODS: The expression and localization of CD147 in six kinds of malignant tumors, their adjacent tissues, and lymph node metastasis specimens were studied by immunohistochemical SP staining.	TFF2 protein, human	180-182	basigin (Ok blood group)	Homo sapiens	44-49
23413783-4	2013	In this study, we found that CD147 was overexpressed in cisplatin-resistant HNSCC cell lines.	Cisplatin	56-65	basigin (Ok blood group)	Homo sapiens	29-34
23828593-5	2013	Additionally, the ERK1/2 inhibitor U0126 were used to confirm the signalling pathway involved in CD147-mediated SGC7901 progression.	U 0126	35-40	basigin (Ok blood group)	Homo sapiens	97-102
23413783-5	2013	Based on the result, CD147 expression was down-regulated in the cisplatin-resistant cell line and we observed that the sensitivity to cisplatin increased, as showed in the results of MTT assay and PI-staining apoptotic detection.	Cisplatin	64-73	basigin (Ok blood group)	Homo sapiens	21-26
23413783-5	2013	Based on the result, CD147 expression was down-regulated in the cisplatin-resistant cell line and we observed that the sensitivity to cisplatin increased, as showed in the results of MTT assay and PI-staining apoptotic detection.	Cisplatin	134-143	basigin (Ok blood group)	Homo sapiens	21-26
23413783-5	2013	Based on the result, CD147 expression was down-regulated in the cisplatin-resistant cell line and we observed that the sensitivity to cisplatin increased, as showed in the results of MTT assay and PI-staining apoptotic detection.	monooxyethylene trimethylolpropane tristearate	183-186	basigin (Ok blood group)	Homo sapiens	21-26
23413783-6	2013	Meanwhile, transfection of CD147 expression vector promoted the occurrence of cisplatin resistance in the cisplatin-sensitive cell line.	Cisplatin	78-87	basigin (Ok blood group)	Homo sapiens	27-32
23413783-6	2013	Meanwhile, transfection of CD147 expression vector promoted the occurrence of cisplatin resistance in the cisplatin-sensitive cell line.	Cisplatin	106-115	basigin (Ok blood group)	Homo sapiens	27-32
23413783-7	2013	Simultaneously blocking of uPAR with neutralizing antibody would significantly prevent the occurrence of cisplatin resistance induced by CD147 overexpression.	Cisplatin	105-114	basigin (Ok blood group)	Homo sapiens	137-142
23413783-8	2013	In conclusion, our study finds that CD147 is also involved in mediating cisplatin resistance in HNSCC and uPAR serves as a possible candidate that collaborates with CD147 in this process.	Cisplatin	72-81	basigin (Ok blood group)	Homo sapiens	36-41
23922889-12	2013	Finally, we show that RPE derived CD147 and integrin-beta1, but not integrin-alpha3, carry predominantly beta-1,6-N-actyl-D-glucosamine-branched glycans, which are high-affinity ligands for Gal-3.	beta-1,6-n-actyl-d-glucosamine-branched glycans	105-152	basigin (Ok blood group)	Homo sapiens	34-39
23922889-13	2013	We conclude from these data that extracellular Gal-3 triggers clustering of CD147 and integrin-beta1 via interaction with beta1,6-branched N-glycans on RPE cells and hypothesize that Gal-3 acts as a positive regulator for CD147/integrin-beta1 clustering and therefore modifies RPE cell behavior contributing to the pathogenesis of PVR.	beta1,6-branched n-glycans	122-148	basigin (Ok blood group)	Homo sapiens	76-81
23622764-3	2013	CD147, highly expressed by psoriatic PBMCs, is assumed to regulate MTX sensitivity.	Methotrexate	67-70	basigin (Ok blood group)	Homo sapiens	0-5
23622764-5	2013	OBJECTIVE: To understand the mechanisms of that CD147 promotes MTX resistance in immune cells.	Methotrexate	63-66	basigin (Ok blood group)	Homo sapiens	48-53
23622764-12	2013	After MTX treatment, CD147 overexpressing CHO cells showed lower apoptosis rate and lower intracellular MTX concentration.	Methotrexate	6-9	basigin (Ok blood group)	Homo sapiens	21-26
23622764-12	2013	After MTX treatment, CD147 overexpressing CHO cells showed lower apoptosis rate and lower intracellular MTX concentration.	Methotrexate	104-107	basigin (Ok blood group)	Homo sapiens	21-26
23622764-13	2013	On the contrary, knockdown of CD147 by shRNA in Jurkat T cells decreased ABCG2 expression, as well as increased MTX-induced apoptosis and decreased MTX efflux.	Methotrexate	112-115	basigin (Ok blood group)	Homo sapiens	30-35
23622764-13	2013	On the contrary, knockdown of CD147 by shRNA in Jurkat T cells decreased ABCG2 expression, as well as increased MTX-induced apoptosis and decreased MTX efflux.	Methotrexate	148-151	basigin (Ok blood group)	Homo sapiens	30-35
23622764-15	2013	CONCLUSION: Our study suggests a role of CD147 in regulating ABCG2 transportation of MTX in immune cells.	Methotrexate	85-88	basigin (Ok blood group)	Homo sapiens	41-46
23622764-16	2013	Strategies involving targeting CD147 could be considered in clinical treatment of psoriatic patients resistant to MTX.	Methotrexate	114-117	basigin (Ok blood group)	Homo sapiens	31-36
23980356-7	2013	RESULTS: The level of serum MMP-3 and the MFI of CD147 on the monocyte surface were obviously higher in RA patients of DHBS than in those of CDBS and the normal control group (P < 0.05).	Sodium 3,5-dichloro-2-hydroxybenzenesulfonate	119-123	basigin (Ok blood group)	Homo sapiens	49-54
23980356-9	2013	The percentage of CD147 expression was obviously lower in DHBS than in those of CDBS and the normal control group (P < 0.05).	Sodium 3,5-dichloro-2-hydroxybenzenesulfonate	58-62	basigin (Ok blood group)	Homo sapiens	18-23
23980356-9	2013	The percentage of CD147 expression was obviously lower in DHBS than in those of CDBS and the normal control group (P < 0.05).	cdbs	80-84	basigin (Ok blood group)	Homo sapiens	18-23
23597945-3	2013	We reported that targeting these pHi-regulated processes through inhibition of either HIF-1-induced CAIX/CAXII or HIF-1-induced MCT4, MCT1 or Basigin/EMMPRIN/CD147 chaperone of MCTs, severely restricts glycolysis-generated ATP levels and tumor growth.	Adenosine Triphosphate	223-226	basigin (Ok blood group)	Homo sapiens	142-149
23597945-3	2013	We reported that targeting these pHi-regulated processes through inhibition of either HIF-1-induced CAIX/CAXII or HIF-1-induced MCT4, MCT1 or Basigin/EMMPRIN/CD147 chaperone of MCTs, severely restricts glycolysis-generated ATP levels and tumor growth.	Adenosine Triphosphate	223-226	basigin (Ok blood group)	Homo sapiens	150-157
23597945-3	2013	We reported that targeting these pHi-regulated processes through inhibition of either HIF-1-induced CAIX/CAXII or HIF-1-induced MCT4, MCT1 or Basigin/EMMPRIN/CD147 chaperone of MCTs, severely restricts glycolysis-generated ATP levels and tumor growth.	Adenosine Triphosphate	223-226	basigin (Ok blood group)	Homo sapiens	158-163
23554123-6	2013	siRNA-mediated silencing of CD147 gene expression restored the sensitivity of CSC-like cells to 5-fluorouracil (5-FU), along with decreasing the expression of thymidylate synthase, p-AKT, and beta-catenin, while increasing the expression of p-glycogen synthase kinase (GSK)3beta.	Fluorouracil	96-110	basigin (Ok blood group)	Homo sapiens	28-33
23554123-6	2013	siRNA-mediated silencing of CD147 gene expression restored the sensitivity of CSC-like cells to 5-fluorouracil (5-FU), along with decreasing the expression of thymidylate synthase, p-AKT, and beta-catenin, while increasing the expression of p-glycogen synthase kinase (GSK)3beta.	Fluorouracil	112-116	basigin (Ok blood group)	Homo sapiens	28-33
23528058-0	2013	Propranolol induces apoptosis of human umbilical vein endothelial cells through downregulation of CD147.	Propranolol	0-11	basigin (Ok blood group)	Homo sapiens	98-103
23622764-0	2013	CD147 promotes MTX resistance by immune cells through up-regulating ABCG2 expression and function.	Methotrexate	15-18	basigin (Ok blood group)	Homo sapiens	0-5
23528058-5	2013	OBJECTIVES: To investigate the role of CD147 in propranolol-induced apoptosis in human umbilical vein endothelial cells (HUVECs).	Propranolol	48-59	basigin (Ok blood group)	Homo sapiens	39-44
23528058-14	2013	Knocking down CD147 not only induced apoptosis but also exacerbated the apoptosis triggered by propranolol in HUVECs.	Propranolol	95-106	basigin (Ok blood group)	Homo sapiens	14-19
23528058-15	2013	Overexpression of CD147 can protect HUVECs from apoptosis and propranolol-induced apoptosis.	Propranolol	62-73	basigin (Ok blood group)	Homo sapiens	18-23
23528058-16	2013	Furthermore, knockdown of both propranolol and CD147 can downregulate Ser112 phosphorylation of BAD, indicating that propranolol and CD147 induce apoptosis in HUVECs through the same signalling transduction pathway.	Propranolol	31-42	basigin (Ok blood group)	Homo sapiens	133-138
23528058-16	2013	Furthermore, knockdown of both propranolol and CD147 can downregulate Ser112 phosphorylation of BAD, indicating that propranolol and CD147 induce apoptosis in HUVECs through the same signalling transduction pathway.	Propranolol	117-128	basigin (Ok blood group)	Homo sapiens	47-52
23528058-17	2013	CONCLUSIONS: Our studies demonstrate that propranolol-induced apoptosis may be mediated through the downregulation of CD147 in HUVECs.	Propranolol	42-53	basigin (Ok blood group)	Homo sapiens	118-123
23005037-0	2013	Modulation of CD147-induced matrix metalloproteinase activity: role of CD147 N-glycosylation.	Nitrogen	77-78	basigin (Ok blood group)	Homo sapiens	71-76
23005037-3	2013	In the present study, mass spectrum analysis demonstrated that the purified native CD147 from human lung cancer tissue was N-glycosylated and contained a series of high-mannose and complex-type N-linked glycan structures.	Mannose	169-176	basigin (Ok blood group)	Homo sapiens	83-88
23005037-3	2013	In the present study, mass spectrum analysis demonstrated that the purified native CD147 from human lung cancer tissue was N-glycosylated and contained a series of high-mannose and complex-type N-linked glycan structures.	n-linked glycan	194-209	basigin (Ok blood group)	Homo sapiens	83-88
23005037-9	2013	The present study reveals the important role of N-glycosylation of CD147 in its biological function and implied that targeting aberrant beta1,6-branching of N-glycans on CD147 would be valuable for the development of novel therapeutic modalities against carcinoma.	Nitrogen	48-49	basigin (Ok blood group)	Homo sapiens	67-72
23005037-9	2013	The present study reveals the important role of N-glycosylation of CD147 in its biological function and implied that targeting aberrant beta1,6-branching of N-glycans on CD147 would be valuable for the development of novel therapeutic modalities against carcinoma.	Nitrogen	48-49	basigin (Ok blood group)	Homo sapiens	170-175
23005037-9	2013	The present study reveals the important role of N-glycosylation of CD147 in its biological function and implied that targeting aberrant beta1,6-branching of N-glycans on CD147 would be valuable for the development of novel therapeutic modalities against carcinoma.	n-glycans	157-166	basigin (Ok blood group)	Homo sapiens	67-72
23005037-9	2013	The present study reveals the important role of N-glycosylation of CD147 in its biological function and implied that targeting aberrant beta1,6-branching of N-glycans on CD147 would be valuable for the development of novel therapeutic modalities against carcinoma.	n-glycans	157-166	basigin (Ok blood group)	Homo sapiens	170-175
23097496-6	2012	CD147(CG) turnover was blocked by kifunensine, and interaction of OS-9 and XTP3-B with CD147(CG) was inhibited by mutations to conserved residues in their lectin domains.	kifunensine	34-45	basigin (Ok blood group)	Homo sapiens	0-9
23255920-7	2013	We also observed that EMMPRIN/CD147 was expressed in Saos-2, U-2OS, MG-63 and A375, but not in HOB cells.	Magnesium	68-70	basigin (Ok blood group)	Homo sapiens	22-29
23255920-7	2013	We also observed that EMMPRIN/CD147 was expressed in Saos-2, U-2OS, MG-63 and A375, but not in HOB cells.	Magnesium	68-70	basigin (Ok blood group)	Homo sapiens	30-35
22729071-6	2012	Treatment of HES cells with estradiol or phorbyl 12-myristate-13-acetate increased the release of EMMPRIN-containing microvesicles.	Estradiol	28-37	basigin (Ok blood group)	Homo sapiens	98-105
23012390-2	2012	Previous studies indicate estradiol can increase EMMPRIN expression in uterine cells and promote subsequent induction of MMP production.	Estradiol	26-35	basigin (Ok blood group)	Homo sapiens	49-56
22729071-6	2012	Treatment of HES cells with estradiol or phorbyl 12-myristate-13-acetate increased the release of EMMPRIN-containing microvesicles.	phorbyl 12-myristate-13-acetate	41-72	basigin (Ok blood group)	Homo sapiens	98-105
22555451-1	2012	Cyclophilin, a cytosolic receptor for the immunosuppressive drug cyclosporin A, plays a role in diverse pathophysiologies along with its receptor, CD147.	Cyclosporine	65-78	basigin (Ok blood group)	Homo sapiens	147-152
23232515-2	2012	METHODS: The effects of As(2);O(3); on cell migration and invasion were examined by wound-healing and Transwell assays;  The expressions of CD147 and MMP-2 at both mRNA and protein levels in SMMC-7721 cells treated with As(2);O(3); were determined by real-time PCR and Western blotting,  respectively.	Aligeron	220-225	basigin (Ok blood group)	Homo sapiens	140-145
22595757-5	2012	By phosphorylating FAK and Src, CD147-enhanced TFII-I tyrosine phosphorylation at Tyr248.	Tyrosine	54-62	basigin (Ok blood group)	Homo sapiens	32-37
22130661-0	2012	Extracellular membrane-proximal domain of HAb18G/CD147 binds to metal ion-dependent adhesion site (MIDAS) motif of integrin beta1 to modulate malignant properties of hepatoma cells.	Metals	64-69	basigin (Ok blood group)	Homo sapiens	49-54
22200845-8	2012	Collectively, this is the first study to suggest that baicalin             induces autophagic cell death in SMMC-7721 cells, which involves the downregulation             of CD147.	baicalin	54-62	basigin (Ok blood group)	Homo sapiens	174-179
21494920-1	2012	PURPOSE: The objective of this study is to evaluate the therapeutic response to a novel monoclonal antibody targeting human extracellular matrix metalloproteinase inducer (EMMPRIN) in combination with gemcitabine in a pancreatic-tumor xenograft murine model by sequential 2-deoxy-2-[18F]fluoro-D-glucose ((18)F-FDG) positron emission tomography/computed tomgraphy (PET/CT) imaging.	Fluorodeoxyglucose F18	272-303	basigin (Ok blood group)	Homo sapiens	124-170
21494920-1	2012	PURPOSE: The objective of this study is to evaluate the therapeutic response to a novel monoclonal antibody targeting human extracellular matrix metalloproteinase inducer (EMMPRIN) in combination with gemcitabine in a pancreatic-tumor xenograft murine model by sequential 2-deoxy-2-[18F]fluoro-D-glucose ((18)F-FDG) positron emission tomography/computed tomgraphy (PET/CT) imaging.	Fluorodeoxyglucose F18	272-303	basigin (Ok blood group)	Homo sapiens	172-179
22130661-6	2012	We found that the extracellular membrane-proximal domain of HAb18G/CD147 (I-type domain) binds at the metal ion-dependent adhesion site in the betaA domain of the integrin beta1 subunit, and Asp(179) in the I-type domain of HAb18G/CD147 plays an important role in the interaction.	Metals	102-107	basigin (Ok blood group)	Homo sapiens	67-72
22130661-6	2012	We found that the extracellular membrane-proximal domain of HAb18G/CD147 (I-type domain) binds at the metal ion-dependent adhesion site in the betaA domain of the integrin beta1 subunit, and Asp(179) in the I-type domain of HAb18G/CD147 plays an important role in the interaction.	Metals	102-107	basigin (Ok blood group)	Homo sapiens	231-236
22130661-6	2012	We found that the extracellular membrane-proximal domain of HAb18G/CD147 (I-type domain) binds at the metal ion-dependent adhesion site in the betaA domain of the integrin beta1 subunit, and Asp(179) in the I-type domain of HAb18G/CD147 plays an important role in the interaction.	Aspartic Acid	191-194	basigin (Ok blood group)	Homo sapiens	67-72
22130661-6	2012	We found that the extracellular membrane-proximal domain of HAb18G/CD147 (I-type domain) binds at the metal ion-dependent adhesion site in the betaA domain of the integrin beta1 subunit, and Asp(179) in the I-type domain of HAb18G/CD147 plays an important role in the interaction.	Aspartic Acid	191-194	basigin (Ok blood group)	Homo sapiens	231-236
22130661-9	2012	These results indicate that the interaction of HAb18G/CD147 extracellular I-type domain with the integrin beta1 metal ion-dependent adhesion site motif activates the downstream FAK signaling pathway, subsequently enhancing the malignant properties of HCC cells.	Metals	112-117	basigin (Ok blood group)	Homo sapiens	54-59
22140092-0	2012	Suppression of oxLDL-induced MMP-9 and EMMPRIN expression by berberine via inhibition of NF-kappaB activation in human THP-1 macrophages.	Berberine	61-70	basigin (Ok blood group)	Homo sapiens	39-46
22350013-9	2012	We observed that butyrate treatment induced localization of MCT1 in the plasma membrane as well as overexpression of MCT4 and its chaperone CD147.	Butyrates	17-25	basigin (Ok blood group)	Homo sapiens	140-145
22140092-3	2012	In the present study, the function of berberine, a natural extract from Rhizoma coptidis, on MMP-9 and EMMPRIN expression, the role of NF-kappaB activation in oxLDL-stimulated macrophages, and the possible mechanism in which NF-kappaB activation is involved were investigated.	Berberine	38-47	basigin (Ok blood group)	Homo sapiens	103-110
22140092-4	2012	Berberine inhibited the expression of MMP-9 and EMMPRIN at both mRNA and protein levels.	Berberine	0-9	basigin (Ok blood group)	Homo sapiens	48-55
22140092-6	2012	Overall, berberine suppressed the expression of MMP-9 and EMMPRIN by at least reducing partly the activity of NF-kappaB in oxLDL-induced macrophages.	Berberine	9-18	basigin (Ok blood group)	Homo sapiens	58-65
22844419-4	2012	We found that CD147-expressing cancer cells could promote HUVECs to form net-like structures resembling the neo-vasculature, whereas the ability of proliferation, migration and tube formation of HUVECs was significantly decreased in tumor conditioned medium (TCM) of SMMC-7721 cells transfected with specific CD147-siRNA.	smmc	267-271	basigin (Ok blood group)	Homo sapiens	14-19
22870202-9	2012	Our results indicated that KD of CD44 or CD147 decreased MCT4 and MRP2 expression, reduced CaP proliferation and invasive potential and enhanced DTX sensitivity; and KD of CD44 or CD147 down-regulated p-Akt and p-Erk, the main signal modulators associated with cell growth and survival.	Docetaxel	145-148	basigin (Ok blood group)	Homo sapiens	41-46
22870202-9	2012	Our results indicated that KD of CD44 or CD147 decreased MCT4 and MRP2 expression, reduced CaP proliferation and invasive potential and enhanced DTX sensitivity; and KD of CD44 or CD147 down-regulated p-Akt and p-Erk, the main signal modulators associated with cell growth and survival.	Docetaxel	145-148	basigin (Ok blood group)	Homo sapiens	180-185
22870202-10	2012	In vivo, CD44 or CD147-KD PC-3M-luc xenografts displayed suppressed tumor growth with increased DTX responsiveness compared to control xenografts.	Docetaxel	96-99	basigin (Ok blood group)	Homo sapiens	17-22
22844419-4	2012	We found that CD147-expressing cancer cells could promote HUVECs to form net-like structures resembling the neo-vasculature, whereas the ability of proliferation, migration and tube formation of HUVECs was significantly decreased in tumor conditioned medium (TCM) of SMMC-7721 cells transfected with specific CD147-siRNA.	smmc	267-271	basigin (Ok blood group)	Homo sapiens	309-314
21809360-7	2011	CONCLUSION: These results suggest that the interaction of HAb18G/CD147 with annexin II is involved in the interconversion between mesenchymal and amoeboid movement of hepatocellular carcinoma cells.	hab18g	58-64	basigin (Ok blood group)	Homo sapiens	65-70
22129926-5	2011	Protein expression in paraffin-embedded specimens of prostates gathered from 300 patients with PCa was detected by immunohistochemistry using a monoclonal antibody against EMMPRIN.	Paraffin	22-30	basigin (Ok blood group)	Homo sapiens	172-179
21809360-6	2011	HAb18G/CD147 inhibits Rho signaling pathways and amoeboid movement by inhibiting annexin II phosphorylation, promotes membrane localization of WAVE2 and Rac1 activation by way of the integrin-FAK-PI3K/PIP3 signaling pathway, and promotes the formation of lamellipodia and mesenchymal movement.	hab18g	0-6	basigin (Ok blood group)	Homo sapiens	7-12
20473759-0	2011	Sinomenine reduces invasion and migration ability in fibroblast-like synoviocytes cells co-cultured with activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, CD147.	sinomenine	0-10	basigin (Ok blood group)	Homo sapiens	189-194
21835259-6	2011	Cysteine proteinase (gingipain)-deficient P. gingivalis mutants were used to demonstrate that both Arg- and Lys-gingipain activities are involved in EMMPRIN shedding.	Arginine	99-102	basigin (Ok blood group)	Homo sapiens	149-156
21871883-0	2011	Inhibiting effects of Leflunomide metabolite on overexpression of CD147, MMP-2 and MMP-9 in PMA differentiated THP-1 cells.	Leflunomide	22-33	basigin (Ok blood group)	Homo sapiens	66-71
21871883-4	2011	The effect of leflunomide in blocking the up-regulation of CD147 and in blocking the down-regulation of metalloproteinases (MMP)-2 and MMP-9 in active macrophages has not yet been established.	Leflunomide	14-25	basigin (Ok blood group)	Homo sapiens	59-64
21871883-5	2011	In this study we investigated the effect of A771726, the active metabolite of leflunomide, on expression of CD147 and on the gelatinolytic activity of MMP-2 and MMP-9 in phorbol myristate acetate (PMA) differentiated THP-1 cells.	Leflunomide	78-89	basigin (Ok blood group)	Homo sapiens	108-113
21871883-8	2011	Our results indicate that A771726, the active metabolite of leflunomide, inhibited CD147 expression at the protein level and inhibited gelatinolytic activity of MMP-2 and MMP-9 in PMA-differentiated THP-1 cells.	Leflunomide	60-71	basigin (Ok blood group)	Homo sapiens	83-88
21930917-0	2011	CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors.	Lactic Acid	17-24	basigin (Ok blood group)	Homo sapiens	0-5
21930917-2	2011	Lactic acid is mainly transported by two H(+)/lactate symporters, MCT1/MCT4, that require the ancillary protein CD147/Basigin for their functionality.	Lactic Acid	0-11	basigin (Ok blood group)	Homo sapiens	112-117
21930917-2	2011	Lactic acid is mainly transported by two H(+)/lactate symporters, MCT1/MCT4, that require the ancillary protein CD147/Basigin for their functionality.	Lactic Acid	0-11	basigin (Ok blood group)	Homo sapiens	118-125
21930917-2	2011	Lactic acid is mainly transported by two H(+)/lactate symporters, MCT1/MCT4, that require the ancillary protein CD147/Basigin for their functionality.	Lactic Acid	46-53	basigin (Ok blood group)	Homo sapiens	112-117
21930917-2	2011	Lactic acid is mainly transported by two H(+)/lactate symporters, MCT1/MCT4, that require the ancillary protein CD147/Basigin for their functionality.	Lactic Acid	46-53	basigin (Ok blood group)	Homo sapiens	118-125
21930917-11	2011	Collectively, these findings highlight that the major protumoral action of CD147/Basigin is to control the energetics of glycolytic tumors via MCT1/MCT4 activity and that blocking lactic acid export provides an efficient anticancer strategy.	Lactic Acid	180-191	basigin (Ok blood group)	Homo sapiens	75-80
21930917-11	2011	Collectively, these findings highlight that the major protumoral action of CD147/Basigin is to control the energetics of glycolytic tumors via MCT1/MCT4 activity and that blocking lactic acid export provides an efficient anticancer strategy.	Lactic Acid	180-191	basigin (Ok blood group)	Homo sapiens	81-88
20629990-7	2011	In vivo and in vitro analysis indicated that demethylation with 5-Aza-2"-deoxycytidine led to increased CD147 expression through enhancing Sp1 binding affinity, and methylation with methyltransferase reduced CD147 transcriptional activity through interfering Sp1 binding.	Decitabine	64-86	basigin (Ok blood group)	Homo sapiens	104-109
21660043-4	2011	Interactions between hyaluronan and hyaluronan receptors on the cell surface also facilitate emmprin-mediated chemoresistance.	Hyaluronic Acid	21-31	basigin (Ok blood group)	Homo sapiens	93-100
21660043-8	2011	Finally, disruption of hyaluronan-receptor interactions using small hyaluronan oligosaccharides reduces expression of emmprin and BCRP while sensitizing PEL cells to chemotherapy.	hyaluronan oligosaccharides	68-95	basigin (Ok blood group)	Homo sapiens	118-125
21777561-6	2011	Exogenously added recombinant EMMPRIN had similar effects that were abrogated in the presence of the MMP inhibitor marimastat.	marimastat	115-125	basigin (Ok blood group)	Homo sapiens	30-37
21448785-6	2011	EMMPRIN expression in a series of 56 MB with various grades and pathological types was analyzed by immunohistochemical staining on paraffin-embedded sections.	Paraffin	131-139	basigin (Ok blood group)	Homo sapiens	0-7
21762534-0	2011	Synthetic emmprin peptides with chitobiose substitution stimulate MMP-2 production by fibroblasts.	Peptides	18-26	basigin (Ok blood group)	Homo sapiens	10-17
21762534-3	2011	The dependence of emmprin activity on N-glycosylation is controversial.	Nitrogen	38-39	basigin (Ok blood group)	Homo sapiens	18-25
21762534-8	2011	CONCLUSIONS: Our results indicate that ECI can mimic emmprin activity when substituted with chitobiose, the disaccharide with which N-glycosylation starts.	Disaccharides	108-120	basigin (Ok blood group)	Homo sapiens	53-60
21762534-8	2011	CONCLUSIONS: Our results indicate that ECI can mimic emmprin activity when substituted with chitobiose, the disaccharide with which N-glycosylation starts.	Nitrogen	2-3	basigin (Ok blood group)	Homo sapiens	53-60
21443647-7	2011	Our data provide the first experimental evidence that berberine induces cell death in HCC cells via downregulation of CD147 and suggest a new mechanism to explain its anti-tumor effects.	Berberine	54-63	basigin (Ok blood group)	Homo sapiens	118-123
21637915-5	2011	Only the second peptide (emp#2), which contains a putative N-glycosylation site sequence, inhibited emmprin-stimulated production of MMP-2 in co-cultures of fibroblasts and several different human tumor cells types, including carcinoma, sarcoma, melanoma, leukemia and glioma cells.	Nitrogen	59-60	basigin (Ok blood group)	Homo sapiens	100-107
21443647-0	2011	Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147.	Berberine	0-9	basigin (Ok blood group)	Homo sapiens	80-85
21443647-5	2011	Moreover, berberine treatment significantly inhibited CD147 expression by HCC cells in a dose-dependent manner.	Berberine	10-19	basigin (Ok blood group)	Homo sapiens	54-59
21443647-6	2011	Overexpression of CD147 protein markedly reduced berberine-induced cell death.	Berberine	49-58	basigin (Ok blood group)	Homo sapiens	18-23
21039753-8	2011	Artemisinin (20-80 mug/mL) significantly inhibited the induction of EMMPRIN and MMP-9 at both the transcriptional and translational levels in a dose-dependent manner in PMA-induced macrophages.	artemisinin	0-11	basigin (Ok blood group)	Homo sapiens	68-75
21327328-9	2011	Exogenous nicotinamide mononucleotide (NMN), the product of nicotinamide phosphoribosyltransferase (NAMPT) activity, mimicked the effects of visfatin on MAPK (p38, ERK1/2)-NF-kappaB activation and EMMPRIN/MMP-9 induction.	Nicotinamide Mononucleotide	10-37	basigin (Ok blood group)	Homo sapiens	197-204
21327328-9	2011	Exogenous nicotinamide mononucleotide (NMN), the product of nicotinamide phosphoribosyltransferase (NAMPT) activity, mimicked the effects of visfatin on MAPK (p38, ERK1/2)-NF-kappaB activation and EMMPRIN/MMP-9 induction.	Nicotinamide Mononucleotide	39-42	basigin (Ok blood group)	Homo sapiens	197-204
19836228-2	2011	METHODS: VEGF and EMMPRIN expression in paraffin-embedded specimens gathered from 65 patients with primary osteosarcoma were detected by the method of immunohistochemistry using antibodies against VEGF and EMMPRIN.	Paraffin	40-48	basigin (Ok blood group)	Homo sapiens	18-25
21464539-0	2011	Effect of CD147 monoclonal antibody on paclitaxel resistance in HCE1 multicellular spheroids.	Paclitaxel	39-49	basigin (Ok blood group)	Homo sapiens	10-15
21464539-1	2011	OBJECTIVE: To investigate the effect of CD147 monoclonal antibody (mAb) on the natural resistance to paclitaxel (TAX) in the human cervical cancer line (HCE1) multicellular spheroid (HCE1/MCS) model and if CD147 mAb can reverse the HCE1/MCS resistance to TAX.	Paclitaxel	101-111	basigin (Ok blood group)	Homo sapiens	40-45
21464539-13	2011	Combined with TAX, CD147 mAb could also induce HCE1/MCS cell cycle arrest in both G1/S and G2/M stage.	tax	14-17	basigin (Ok blood group)	Homo sapiens	19-24
21039753-0	2011	Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cdelta/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages.	artemisinin	0-11	basigin (Ok blood group)	Homo sapiens	21-67
21518083-8	2011	Emmprin and stratifin were shown to stimulate fibroblast hyaluronan synthesis, and the hyaluronan-stimulating activity of KCM was removed following stratifin depletion and to a lesser extent by emmprin depletion.	Hyaluronic Acid	57-67	basigin (Ok blood group)	Homo sapiens	0-7
20446926-0	2011	(-)-Epigallocatechin-3-gallate down-regulates EGFR, MMP-2, MMP-9 and EMMPRIN and inhibits the invasion of MCF-7 tamoxifen-resistant cells.	epigallocatechin gallate	0-30	basigin (Ok blood group)	Homo sapiens	69-76
20446926-7	2011	MMP-2 (matrix metalloproteinase-2) and MMP-9, which are implicated in cell invasion and metastasis, and EMMPRIN (extracellular matrix metalloproteinase inducer), a glycoprotein able to activate MMPs, were significantly reduced after 50 mug/ml EGCG treatment.	epigallocatechin gallate	243-247	basigin (Ok blood group)	Homo sapiens	104-111
20446926-7	2011	MMP-2 (matrix metalloproteinase-2) and MMP-9, which are implicated in cell invasion and metastasis, and EMMPRIN (extracellular matrix metalloproteinase inducer), a glycoprotein able to activate MMPs, were significantly reduced after 50 mug/ml EGCG treatment.	epigallocatechin gallate	243-247	basigin (Ok blood group)	Homo sapiens	113-159
19576641-0	2011	Berberine reduces both MMP-9 and EMMPRIN expression through prevention of p38 pathway activation in PMA-induced macrophages.	Berberine	0-9	basigin (Ok blood group)	Homo sapiens	33-40
19576641-3	2011	The purpose of our study was to determine if berberine, a natural extract from Rhizoma coptidis, had any effect on the expression of MMP-9 and EMMPRIN in PMA-induced macrophages.	Berberine	45-54	basigin (Ok blood group)	Homo sapiens	143-150
19576641-6	2011	RESULTS: In the present study, we demonstrated that berberine inhibited the expression of MMP-9 and EMMPRIN at both the mRNA and protein levels in a dose-dependent manner in PMA-induced macrophages, and that it also reduced MMP-9 activity.	Berberine	52-61	basigin (Ok blood group)	Homo sapiens	100-107
19576641-8	2011	CONCLUSIONS: The data indicate that berberine reduces MMP-9 and EMMPRIN expression by suppressing the activation of p38 pathway in PMA-induced macrophages.	Berberine	36-45	basigin (Ok blood group)	Homo sapiens	64-71
21039753-0	2011	Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cdelta/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages.	artemisinin	0-11	basigin (Ok blood group)	Homo sapiens	69-76
21039753-0	2011	Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cdelta/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages.	Tetradecanoylphorbol Acetate	201-226	basigin (Ok blood group)	Homo sapiens	21-67
21039753-0	2011	Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cdelta/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages.	Tetradecanoylphorbol Acetate	201-226	basigin (Ok blood group)	Homo sapiens	69-76
21039753-3	2011	The aim of the present study was to explore whether artemisinin, a natural extract from Artemisia annua, could decrease EMMPRIN and MMP-9 expression in phorbol myristate acetate (PMA)-induced macrophages by regulating the protein kinase (PK) Cdelta/c-Jun N-terminal kinase (JNK)/p38/extracellular signal-regulated kinase (ERK) pathway.	artemisinin	52-63	basigin (Ok blood group)	Homo sapiens	120-127
21039753-3	2011	The aim of the present study was to explore whether artemisinin, a natural extract from Artemisia annua, could decrease EMMPRIN and MMP-9 expression in phorbol myristate acetate (PMA)-induced macrophages by regulating the protein kinase (PK) Cdelta/c-Jun N-terminal kinase (JNK)/p38/extracellular signal-regulated kinase (ERK) pathway.	Tetradecanoylphorbol Acetate	152-177	basigin (Ok blood group)	Homo sapiens	120-127
21039753-3	2011	The aim of the present study was to explore whether artemisinin, a natural extract from Artemisia annua, could decrease EMMPRIN and MMP-9 expression in phorbol myristate acetate (PMA)-induced macrophages by regulating the protein kinase (PK) Cdelta/c-Jun N-terminal kinase (JNK)/p38/extracellular signal-regulated kinase (ERK) pathway.	Tetradecanoylphorbol Acetate	179-182	basigin (Ok blood group)	Homo sapiens	120-127
21039753-10	2011	The PKCdelta inhibitor rottlerin (1-10 mumol/L) also significantly inhibited JNK/p38/ERK phosphorylation and decreased EMMPRIN and MMP-9 mRNA and protein expression.	rottlerin	23-32	basigin (Ok blood group)	Homo sapiens	119-126
21039753-12	2011	The results of the present study suggest that artemisinin inhibits EMMPRIN and MMP-9 expression and activity by suppressing the PKCdelta/ERK/p38 cascade in PMA-induced macrophages.	artemisinin	46-57	basigin (Ok blood group)	Homo sapiens	67-74
21039753-12	2011	The results of the present study suggest that artemisinin inhibits EMMPRIN and MMP-9 expression and activity by suppressing the PKCdelta/ERK/p38 cascade in PMA-induced macrophages.	Tetradecanoylphorbol Acetate	156-159	basigin (Ok blood group)	Homo sapiens	67-74
20082657-6	2010	Further functional studies showed that the ligation of HAb18G/CD147 with mAb 5A12 decreased the tyrosine phosphorylation and intracellular calcium mobilization levels of T cells.	Tyrosine	96-104	basigin (Ok blood group)	Homo sapiens	62-67
21745000-0	2011	Expression of CD147 in advanced non-small cell lung cancer correlated with cisplatin-based chemotherapy resistance.	Cisplatin	75-84	basigin (Ok blood group)	Homo sapiens	14-19
21745000-5	2011	Furthermore, RNA interference approach was used to silence CD147 expression in a cisplatin-resistant human lung cancer cell line A549/DDP, and the inhibition effect of cisplatin on tumor cells was assayed by MTT.	Cisplatin	81-90	basigin (Ok blood group)	Homo sapiens	59-64
21745000-5	2011	Furthermore, RNA interference approach was used to silence CD147 expression in a cisplatin-resistant human lung cancer cell line A549/DDP, and the inhibition effect of cisplatin on tumor cells was assayed by MTT.	Cisplatin	168-177	basigin (Ok blood group)	Homo sapiens	59-64
21745000-8	2011	CD147 membranous expression,but not the overall CD147 expression, was associated with poor response to cisplatin-based chemotherapies and a poor prognosis in advanced NSCLC patients.	Cisplatin	103-112	basigin (Ok blood group)	Homo sapiens	0-5
21745000-9	2011	In vitro results showed that silencing CD147 increased the proliferation inhibitory effect of cisplatin to A549/DDP cells.	Cisplatin	94-103	basigin (Ok blood group)	Homo sapiens	39-44
21745000-10	2011	In conclusion, our study indicated that membranous CD147 expression is a predictive factor of the response to cisplatin-based chemotherapies, and the use of CD147-targeted therapeutic adjuvants might be considered in the treatment of advanced NSCLC patients.	Cisplatin	110-119	basigin (Ok blood group)	Homo sapiens	51-56
21035802-8	2010	The current study shows that CyPA-EMMPRIN interaction is one of the key pro-inflammatory signaling pathways in monocytes, perhaps especially in response to ROS stimulation.	Reactive Oxygen Species	156-159	basigin (Ok blood group)	Homo sapiens	34-41
20563831-0	2010	The effect of the expression of angiotensin II on extracellular matrix metalloproteinase inducer (EMMPRIN) in macrophages is mediated via the AT1/COX-2/PGE2 pathway.	Dinoprostone	152-156	basigin (Ok blood group)	Homo sapiens	50-96
20563831-0	2010	The effect of the expression of angiotensin II on extracellular matrix metalloproteinase inducer (EMMPRIN) in macrophages is mediated via the AT1/COX-2/PGE2 pathway.	Dinoprostone	152-156	basigin (Ok blood group)	Homo sapiens	98-105
20563831-6	2010	RESULTS: Ang II clearly induced the expression of EMMPRIN mRNA and protein in macrophages; this expression peaked at 12 h and declined after 24 h. The tendency of enhancement of the levels of cyclooxygenase-2 (COX-2) and PGE(2) was coincident with EMMPRIN expression.	Prostaglandins E	221-224	basigin (Ok blood group)	Homo sapiens	50-57
20563831-8	2010	CONCLUSION: Ang II can up-regulate EMMPRIN expression in THP-1 macrophages via the AT(1)/COX-2/PGE(2) signal transduction pathway, and the effect can be inhibited by losartan and NS-398.	Prostaglandins E	95-98	basigin (Ok blood group)	Homo sapiens	35-42
20563831-8	2010	CONCLUSION: Ang II can up-regulate EMMPRIN expression in THP-1 macrophages via the AT(1)/COX-2/PGE(2) signal transduction pathway, and the effect can be inhibited by losartan and NS-398.	Losartan	166-174	basigin (Ok blood group)	Homo sapiens	35-42
20563831-8	2010	CONCLUSION: Ang II can up-regulate EMMPRIN expression in THP-1 macrophages via the AT(1)/COX-2/PGE(2) signal transduction pathway, and the effect can be inhibited by losartan and NS-398.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	179-185	basigin (Ok blood group)	Homo sapiens	35-42
19921476-5	2010	The expression of EMMPRIN and MMP-2 was detected in 117/150 (78.0%) and 115/150 (76.7%) of patients with PCMM, respectively.	2-Carbamoyl-1-methylpyridinium iodide	105-109	basigin (Ok blood group)	Homo sapiens	18-25
21211394-10	2010	The expression levels of CD147 mRNA in PBMC of AS and RA group were significantly higher than those of HC group (P < 0.05) while no significant difference was found between AS and RA group (P > 0.05).	Hydrocortisone	103-105	basigin (Ok blood group)	Homo sapiens	25-30
20558462-2	2010	METHODS: Immunohistochemical staining was performed to detect the expression of CD147 and vascular endothelial growth factor in paraffin-embedded sections from 62 bone marrow biopsies obtained from an equal number of patients with newly diagnosed acute myeloid leukemia.	Paraffin	128-136	basigin (Ok blood group)	Homo sapiens	80-85
20736947-4	2010	The relationship between the expression of CD147 and CD44v3-10 and the sensitivity (IC(50)) to docetaxel in CaP cell lines was assessed using MTT assay.	Docetaxel	95-104	basigin (Ok blood group)	Homo sapiens	43-48
20736947-4	2010	The relationship between the expression of CD147 and CD44v3-10 and the sensitivity (IC(50)) to docetaxel in CaP cell lines was assessed using MTT assay.	monooxyethylene trimethylolpropane tristearate	142-145	basigin (Ok blood group)	Homo sapiens	43-48
20736947-7	2010	Both CD147 and CD44v3-10 expression levels were inversely related to docetaxel sensitivity (IC(50)) in metastatic CaP cell lines.	Docetaxel	69-78	basigin (Ok blood group)	Homo sapiens	5-10
21211394-6	2010	RESULTS: The mean fluorescence intensities of CD147 in monocytes of AS, RA and HC group were 213.5 +- 37.8, 228.7 +- 49.7 and 163.6 +- 44.8, and in T lymphocytes 36.8 +- 10.1, 40.2 +- 10.5 and 28.3 +- 10.6 respectively.	Hydrocortisone	79-81	basigin (Ok blood group)	Homo sapiens	46-51
20810913-0	2010	Monocyte CD147 is induced by advanced glycation end products and high glucose concentration: possible role in diabetic complications.	Glucose	70-77	basigin (Ok blood group)	Homo sapiens	9-14
20810913-4	2010	Therefore, in this study we investigated the effect of advanced glycation end products (AGEs) and high glucose (HG; 25 mM), on monocyte CD147 expression.	Glucose	103-110	basigin (Ok blood group)	Homo sapiens	136-141
20483678-1	2010	AIM: Extracellular matrix metalloproteinase inducer (EMMPRIN) has been shown to promote tumor invasion and metastasis via stimulating matrix metalloproteinase synthesis in neighboring fibroblasts, to enhance angiogenesis via vascular endothelial growth factor, to induce chemoresistant tumor cells via the production of hyaluronan, and to confer resistance of cancer cells to anoikis through inhibition of Bim.	Hyaluronic Acid	320-330	basigin (Ok blood group)	Homo sapiens	5-51
20483678-1	2010	AIM: Extracellular matrix metalloproteinase inducer (EMMPRIN) has been shown to promote tumor invasion and metastasis via stimulating matrix metalloproteinase synthesis in neighboring fibroblasts, to enhance angiogenesis via vascular endothelial growth factor, to induce chemoresistant tumor cells via the production of hyaluronan, and to confer resistance of cancer cells to anoikis through inhibition of Bim.	Hyaluronic Acid	320-330	basigin (Ok blood group)	Homo sapiens	53-60
20082657-6	2010	Further functional studies showed that the ligation of HAb18G/CD147 with mAb 5A12 decreased the tyrosine phosphorylation and intracellular calcium mobilization levels of T cells.	Calcium	139-146	basigin (Ok blood group)	Homo sapiens	62-67
19286191-3	2010	METHODS: CD147/EMMPRIN expression in 52 patients with renal carcinoma, 58 patients with bladder carcinoma, 101 patients with prostate carcinoma, 17 patients of penis carcinoma, and 17 patients of testis carcinoma were examined by immunostaining on paraffin-embedded tumor specimens using monoclonal antibodies.	Paraffin	248-256	basigin (Ok blood group)	Homo sapiens	9-14
20681443-7	2010	RESULTS: Compared with the docetaxel-treated group, more obvious down-regulation of expression of MMP-2, EMMPRIN (P = 0.024, P = 0.081) were observed in rh-endostatin-treated group.	Docetaxel	27-36	basigin (Ok blood group)	Homo sapiens	105-112
20525232-0	2010	RNAi-mediated silencing of CD147 inhibits tumor cell proliferation, invasion and increases chemosensitivity to cisplatin in SGC7901 cells in vitro.	Cisplatin	111-120	basigin (Ok blood group)	Homo sapiens	27-32
20525232-7	2010	RESULTS: Down-regulation of CD147 by RNAi approach led to decreased cell proliferation, MMP-2 and MMP-9 activities and invasive potential of SGC7901 cells as well as increased chemosensitivity to cisplatin.	Cisplatin	196-205	basigin (Ok blood group)	Homo sapiens	28-33
20451353-0	2010	Depletion of CD147 sensitizes human malignant melanoma cells to hydrogen peroxide-induced oxidative stress.	Hydrogen Peroxide	64-81	basigin (Ok blood group)	Homo sapiens	13-18
20451353-3	2010	OBJECTIVE: To understand the influences and mechanisms of CD147 on proliferation, apoptosis and redox state of A375 cells under H(2)O(2)-induced oxidative stress.	Hydrogen Peroxide	128-136	basigin (Ok blood group)	Homo sapiens	58-63
20451353-5	2010	RESULTS: In A375 cells, CD147 silencing increased the H(2)O(2)-induced inhibition of cell viability, H(2)O(2)-induced apoptosis, H(2)O(2)-mediated ROS- and MDA generation, and the H(2)O(2)-triggered decrease in SOD activity.	Hydrogen Peroxide	54-62	basigin (Ok blood group)	Homo sapiens	24-29
20451353-5	2010	RESULTS: In A375 cells, CD147 silencing increased the H(2)O(2)-induced inhibition of cell viability, H(2)O(2)-induced apoptosis, H(2)O(2)-mediated ROS- and MDA generation, and the H(2)O(2)-triggered decrease in SOD activity.	Hydrogen Peroxide	101-109	basigin (Ok blood group)	Homo sapiens	24-29
20451353-5	2010	RESULTS: In A375 cells, CD147 silencing increased the H(2)O(2)-induced inhibition of cell viability, H(2)O(2)-induced apoptosis, H(2)O(2)-mediated ROS- and MDA generation, and the H(2)O(2)-triggered decrease in SOD activity.	Hydrogen Peroxide	101-109	basigin (Ok blood group)	Homo sapiens	24-29
20451353-5	2010	RESULTS: In A375 cells, CD147 silencing increased the H(2)O(2)-induced inhibition of cell viability, H(2)O(2)-induced apoptosis, H(2)O(2)-mediated ROS- and MDA generation, and the H(2)O(2)-triggered decrease in SOD activity.	Reactive Oxygen Species	147-150	basigin (Ok blood group)	Homo sapiens	24-29
20451353-5	2010	RESULTS: In A375 cells, CD147 silencing increased the H(2)O(2)-induced inhibition of cell viability, H(2)O(2)-induced apoptosis, H(2)O(2)-mediated ROS- and MDA generation, and the H(2)O(2)-triggered decrease in SOD activity.	Hydrogen Peroxide	101-109	basigin (Ok blood group)	Homo sapiens	24-29
20451353-6	2010	CONCLUSIONS: Our results demonstrated that CD147 silencing increased cellular ROS and destroyed the intrinsic antioxidant defenses in A375, indicating that CD147 exerts a cytoprotective effect against H(2)O(2)-induced oxidative damage.	Reactive Oxygen Species	78-81	basigin (Ok blood group)	Homo sapiens	43-48
20451353-6	2010	CONCLUSIONS: Our results demonstrated that CD147 silencing increased cellular ROS and destroyed the intrinsic antioxidant defenses in A375, indicating that CD147 exerts a cytoprotective effect against H(2)O(2)-induced oxidative damage.	Reactive Oxygen Species	78-81	basigin (Ok blood group)	Homo sapiens	156-161
20451353-6	2010	CONCLUSIONS: Our results demonstrated that CD147 silencing increased cellular ROS and destroyed the intrinsic antioxidant defenses in A375, indicating that CD147 exerts a cytoprotective effect against H(2)O(2)-induced oxidative damage.	Hydrogen Peroxide	201-209	basigin (Ok blood group)	Homo sapiens	43-48
20451353-6	2010	CONCLUSIONS: Our results demonstrated that CD147 silencing increased cellular ROS and destroyed the intrinsic antioxidant defenses in A375, indicating that CD147 exerts a cytoprotective effect against H(2)O(2)-induced oxidative damage.	Hydrogen Peroxide	201-209	basigin (Ok blood group)	Homo sapiens	156-161
19286191-6	2010	The in vitro proliferative ability of CD147/EMMPRIN-deficient cells was determined by a 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT assay.	thiazolyl blue	88-148	basigin (Ok blood group)	Homo sapiens	38-43
19286191-6	2010	The in vitro proliferative ability of CD147/EMMPRIN-deficient cells was determined by a 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT assay.	thiazolyl blue	88-148	basigin (Ok blood group)	Homo sapiens	44-51
19286191-6	2010	The in vitro proliferative ability of CD147/EMMPRIN-deficient cells was determined by a 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT assay.	monooxyethylene trimethylolpropane tristearate	149-152	basigin (Ok blood group)	Homo sapiens	38-43
19286191-6	2010	The in vitro proliferative ability of CD147/EMMPRIN-deficient cells was determined by a 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide MTT assay.	monooxyethylene trimethylolpropane tristearate	149-152	basigin (Ok blood group)	Homo sapiens	44-51
20398401-9	2010	When HAb18G/CD147 was downregulated, E-cadherin expression in HEK293ar cells was significantly suppressed; however, knockdown of E-cadherin by E-cadherin siRNA or blocking of E-cadherin binding activity with a specific antibody and EDTA had no significant effect on HAb18G/CD147 expression.	Edetic Acid	232-236	basigin (Ok blood group)	Homo sapiens	12-17
19576658-0	2010	Cell-permeable ceramides act as novel regulators of U937 cell-cell adhesion mediated by CD29, CD98, and CD147.	Ceramides	15-24	basigin (Ok blood group)	Homo sapiens	104-109
19576658-2	2010	In this study, we report novel modulatory effects of ceramides on the functional activation of beta1 integrins (CD29) and their associated molecules, such as CD98 and CD147, using U937 cell-cell or cell-fibronectin (FN) adhesion events.	Ceramides	53-62	basigin (Ok blood group)	Homo sapiens	167-172
19576658-3	2010	Cell-permeable ceramides (C2- or C6-ceramides) effectively blocked monocytic cell-cell adhesion, mediated by CD29, CD98, and CD147, and cell-FN adhesion in a dose-dependent manner.	Ceramides	15-24	basigin (Ok blood group)	Homo sapiens	125-130
19576658-3	2010	Cell-permeable ceramides (C2- or C6-ceramides) effectively blocked monocytic cell-cell adhesion, mediated by CD29, CD98, and CD147, and cell-FN adhesion in a dose-dependent manner.	Ceramides	36-45	basigin (Ok blood group)	Homo sapiens	125-130
19576658-6	2010	Interestingly, C6-ceramide inhibited the phosphorylation of CD29 induced by MEM101A treatment and down-regulated surface levels of CD29, CD98, and CD147, as well as CD49d.	N-caproylsphingosine	15-26	basigin (Ok blood group)	Homo sapiens	147-152
20021214-0	2010	Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation.	Lactic Acid	20-27	basigin (Ok blood group)	Homo sapiens	81-86
20021816-3	2009	Expression of CD147 and MMP-9 were tested by streptavidin-biotin complex (SABC) immunohistochemistry and its correlation with clinical results were analyzed.	sabc	74-78	basigin (Ok blood group)	Homo sapiens	14-19
19895572-8	2010	PMA treatment also suppressed the surface level of CD98 but not CD29, CD18 and CD147, dose- and time-dependently.	Tetradecanoylphorbol Acetate	0-3	basigin (Ok blood group)	Homo sapiens	79-84
20501436-13	2009	Our findings demonstrate that increased MCT1 association with CD147 at the apical membrane in response to SST is p38 MAP kinase dependent and underlies the stimulatory effects of SST on butyrate uptake.	Butyrates	186-194	basigin (Ok blood group)	Homo sapiens	62-67
19956835-0	2010	Target chemotherapy of anti-CD147 antibody-labeled liposome encapsulated GSH-DXR conjugate on CD147 highly expressed carcinoma cells.	Glutathione	73-76	basigin (Ok blood group)	Homo sapiens	28-33
19956835-0	2010	Target chemotherapy of anti-CD147 antibody-labeled liposome encapsulated GSH-DXR conjugate on CD147 highly expressed carcinoma cells.	Glutathione	73-76	basigin (Ok blood group)	Homo sapiens	94-99
19956835-8	2010	These results suggested that target chemotherapy of GSH-DXR encapsulated in an aCD147ab-liposome on CD147-expressing carcinoma cells was effective.	Glutathione	52-55	basigin (Ok blood group)	Homo sapiens	80-85
20369477-2	2010	METHODS: MIF and CD147 proteins were detected in 40 cases of benign pulmonary tissues, 327 cases of primary NSCLC and 112 cases of lymph node metastatic tissues by SP method of immunohistochemical staining.	TFF2 protein, human	164-166	basigin (Ok blood group)	Homo sapiens	17-22
19815704-4	2009	Interestingly, GGH is a protein associated with methotrexate resistance, whereas emmprin, survivin, and DBI had been previously identified as predictors of outcome after platinum-containing chemotherapeutic regimens when assessed on tumor tissue.	Platinum	170-178	basigin (Ok blood group)	Homo sapiens	81-88
19505879-0	2009	CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models.	Lactic Acid	25-32	basigin (Ok blood group)	Homo sapiens	0-5
19505879-7	2009	CD147 silencing inhibited the expression and function of MCT1 and MCT4 and resulted in an increased intracellular lactate concentration.	Lactic Acid	114-121	basigin (Ok blood group)	Homo sapiens	0-5
20021816-3	2009	Expression of CD147 and MMP-9 were tested by streptavidin-biotin complex (SABC) immunohistochemistry and its correlation with clinical results were analyzed.	Biotin	58-64	basigin (Ok blood group)	Homo sapiens	14-19
19597352-5	2009	Furthermore, downregulation of EMMPRIN by p53 can be rescued by chloroquine, a lysosome inhibitor, but not by MG132, a proteasome inhibitor, suggesting an involvement of the lysosomal pathway in the p53-regulated degradation of EMMPRIN.	Chloroquine	64-75	basigin (Ok blood group)	Homo sapiens	31-38
19775453-10	2009	Wortmannin, a specific phosphatidylinositol kinase (PI3K) inhibitor that reverses the effect of HAb18G/CD147 on the regulation of intracellular Ca2+ mobilization, significantly reduced cell invasion potential and secretion of MMPs in human hepatoma cells (P < 0.05).	Wortmannin	0-10	basigin (Ok blood group)	Homo sapiens	103-108
19775453-10	2009	Wortmannin, a specific phosphatidylinositol kinase (PI3K) inhibitor that reverses the effect of HAb18G/CD147 on the regulation of intracellular Ca2+ mobilization, significantly reduced cell invasion potential and secretion of MMPs in human hepatoma cells (P < 0.05).	hab18g	96-102	basigin (Ok blood group)	Homo sapiens	103-108
19561311-0	2009	Resveratrol blocks interleukin-18-EMMPRIN cross-regulation and smooth muscle cell migration.	Resveratrol	0-11	basigin (Ok blood group)	Homo sapiens	34-41
19048397-4	2009	CD147 protein expression in paraffin-embedded specimens gathered from 62 cases of PCa and 30 cases of benign prostatic hyperplasia (BPH) were detected by the method of immunohistochemistry.	Paraffin	28-36	basigin (Ok blood group)	Homo sapiens	0-5
19561311-6	2009	Resveratrol, via its antioxidant and anti-inflammatory properties, has the potential to inhibit the progression of atherosclerosis by blocking IL-18 and EMMPRIN cross-regulation and SMC migration.	Resveratrol	0-11	basigin (Ok blood group)	Homo sapiens	153-160
19953931-2	2009	METHODS: The method of immunohistochemical SP was employed to detect the expression of CD147 in 101 cases of prostate cancer, 90 cases of benign prostatic hyperplasia, 36 cases of normal prostate and 15 cases of embryonic prostate by so as to evaluate its clinical significance in the histological classification and prognosis of prostate cancer.	TFF2 protein, human	43-45	basigin (Ok blood group)	Homo sapiens	87-92
20021964-0	2009	[High glucose and tea polyphenols on expression of matrix metalloproteinase-2 and extracellular matrix metalloproteinase inducer in human umbilical vein endothelial cells].	Glucose	6-13	basigin (Ok blood group)	Homo sapiens	82-128
20021964-0	2009	[High glucose and tea polyphenols on expression of matrix metalloproteinase-2 and extracellular matrix metalloproteinase inducer in human umbilical vein endothelial cells].	Polyphenols	22-33	basigin (Ok blood group)	Homo sapiens	82-128
20021964-1	2009	OBJECTIVE: To investigate the effects of high glucose on expression of matrix metalloproteinase-2 (MMP-2) and extracellular matrix metalloproteinase inducer (EMMPRIN) in human umbilical vein endothelial cells (HUVECs).	Glucose	46-53	basigin (Ok blood group)	Homo sapiens	110-156
20021964-6	2009	RESULTS: The expression of MMP-2 and EMMPRIN mRNA were suppressed by a high concentration of glucose.	Glucose	93-100	basigin (Ok blood group)	Homo sapiens	37-44
20021964-9	2009	CONCLUSIONS: An acute high glucose stimulation down-regulates the activity of MMP-2, the expressions of MMP-2 and EMMPRIN at RNA and protein levels in the endothelial cells, which may play an important roles in diabetic vascular complications in the early phase.	Glucose	27-34	basigin (Ok blood group)	Homo sapiens	114-121
19329653-13	2009	Extracellular matrix metalloproteinase inducer levels were higher in therapy-resistant tumors and significantly associated with an earlier tumor progression following first line tamoxifen treatment (hazard ratio, 1.87; 95% confidence interval, 1.25-2.80; p = 0.002).	Tamoxifen	178-187	basigin (Ok blood group)	Homo sapiens	0-46
19443639-6	2009	Bsg isolated from HL-60 cells bound to E-selectin, and tunicamycin treatment to abolish N-linked glycans from Bsg abrogated this binding.	Tunicamycin	55-66	basigin (Ok blood group)	Homo sapiens	110-113
19443639-6	2009	Bsg isolated from HL-60 cells bound to E-selectin, and tunicamycin treatment to abolish N-linked glycans from Bsg abrogated this binding.	n-linked glycans	88-104	basigin (Ok blood group)	Homo sapiens	0-3
19443639-6	2009	Bsg isolated from HL-60 cells bound to E-selectin, and tunicamycin treatment to abolish N-linked glycans from Bsg abrogated this binding.	n-linked glycans	88-104	basigin (Ok blood group)	Homo sapiens	110-113
19391040-0	2009	Human T-leukemia and T-lymphoma express glutamate receptor AMPA GluR3, and the neurotransmitter glutamate elevates the cancer-related matrix-metalloproteinases inducer CD147/EMMPRIN, MMP-9 secretion and engraftment of T-leukemia in vivo.	Glutamic Acid	40-49	basigin (Ok blood group)	Homo sapiens	168-173
19391040-4	2009	Furthermore, glutamate (10 nM) elevates CD147/EMMPRIN, a cancer-associated matrix metalloproteinases (MMPs) inducer, promoting spread of many tumors.	Glutamic Acid	13-22	basigin (Ok blood group)	Homo sapiens	40-45
19391040-4	2009	Furthermore, glutamate (10 nM) elevates CD147/EMMPRIN, a cancer-associated matrix metalloproteinases (MMPs) inducer, promoting spread of many tumors.	Glutamic Acid	13-22	basigin (Ok blood group)	Homo sapiens	46-53
19391040-5	2009	Glutamate-induced CD147 elevation in both cancerous and normal human T-cells was mimicked by AMPA (glutamate/AMPA-receptor agonist) and blocked by CNQX (glutamate/AMPA-receptor antagonist).	Glutamic Acid	0-9	basigin (Ok blood group)	Homo sapiens	18-23
19391040-5	2009	Glutamate-induced CD147 elevation in both cancerous and normal human T-cells was mimicked by AMPA (glutamate/AMPA-receptor agonist) and blocked by CNQX (glutamate/AMPA-receptor antagonist).	6-Cyano-7-nitroquinoxaline-2,3-dione	147-151	basigin (Ok blood group)	Homo sapiens	18-23
19391040-5	2009	Glutamate-induced CD147 elevation in both cancerous and normal human T-cells was mimicked by AMPA (glutamate/AMPA-receptor agonist) and blocked by CNQX (glutamate/AMPA-receptor antagonist).	Glutamic Acid	99-108	basigin (Ok blood group)	Homo sapiens	18-23
19298604-6	2009	Using trypan blue exclusion assay, we found that HAb18G/CD147 notably enhanced the survival of SMMC7721 cells through inhibiting starvation-induced autophagy.	Trypan Blue	6-17	basigin (Ok blood group)	Homo sapiens	56-61
19302270-6	2009	Here we identify and validate six new endogenous cargo proteins (CD44, CD55, CD98, CD147, Glut1, and ICAM1) that use CIE to enter cells.	chlorimuron ethyl	117-120	basigin (Ok blood group)	Homo sapiens	83-88
19388146-0	2009	Expression of CD147 on phorbol-12-myristate-13-acetate (PMA)-treated U937 cells differentiating into foam cells.	Tetradecanoylphorbol Acetate	23-54	basigin (Ok blood group)	Homo sapiens	14-19
19388146-0	2009	Expression of CD147 on phorbol-12-myristate-13-acetate (PMA)-treated U937 cells differentiating into foam cells.	Tetradecanoylphorbol Acetate	56-59	basigin (Ok blood group)	Homo sapiens	14-19
19305422-0	2009	Sinomenine influences capacity for invasion and migration in activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, and CD147.	sinomenine	0-10	basigin (Ok blood group)	Homo sapiens	149-154
19097686-7	2009	Additionally, chemo-sensitivity to 5-fluorouracil of KB/V was increased by CD147 silencing as measured by MTT colorimetric assay.	Fluorouracil	35-49	basigin (Ok blood group)	Homo sapiens	75-80
19097686-7	2009	Additionally, chemo-sensitivity to 5-fluorouracil of KB/V was increased by CD147 silencing as measured by MTT colorimetric assay.	monooxyethylene trimethylolpropane tristearate	106-109	basigin (Ok blood group)	Homo sapiens	75-80
19350111-7	2009	ADP-stimulated platelets showed significantly enhanced rolling (but not enhanced firm adhesion) on immobilised EMMPRIN-Fc compared to Fc.	Adenosine Diphosphate	0-3	basigin (Ok blood group)	Homo sapiens	111-118
19019167-10	2009	Epidermal growth factor (50 ng/mL) and phorbol 12-myristate 13-acetate (10(-7) mol/L) stimulated the secretion of soluble EMMPRIN and increased the MMP-2 activity, although these agents did not increase the level of EMMPRIN mRNA.	Tetradecanoylphorbol Acetate	39-70	basigin (Ok blood group)	Homo sapiens	122-129
19019167-10	2009	Epidermal growth factor (50 ng/mL) and phorbol 12-myristate 13-acetate (10(-7) mol/L) stimulated the secretion of soluble EMMPRIN and increased the MMP-2 activity, although these agents did not increase the level of EMMPRIN mRNA.	Tetradecanoylphorbol Acetate	39-70	basigin (Ok blood group)	Homo sapiens	216-223
18778892-3	2009	Our previous results revealed that the over-expressed CD147/basigin plays a critical role in malignant melanoma (MM) invasiveness, metastasis and angiogenesis; CD147 has also been implicated in a specific and strong interaction with monocarboxylate transporters (MCT) 1 and 4 that mediate the transport of lactate.	Lactic Acid	306-313	basigin (Ok blood group)	Homo sapiens	54-59
19176383-0	2009	Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells.	Lactic Acid	39-46	basigin (Ok blood group)	Homo sapiens	22-29
19176383-2	2009	Emmprin (CD147; basigin) is a cell surface glycoprotein of the immunoglobulin superfamily that is highly up-regulated in malignant cancer cells and stimulates hyaluronan production, as well as several downstream signaling pathways.	Hyaluronic Acid	159-169	basigin (Ok blood group)	Homo sapiens	0-7
19176383-2	2009	Emmprin (CD147; basigin) is a cell surface glycoprotein of the immunoglobulin superfamily that is highly up-regulated in malignant cancer cells and stimulates hyaluronan production, as well as several downstream signaling pathways.	Hyaluronic Acid	159-169	basigin (Ok blood group)	Homo sapiens	9-14
19176383-2	2009	Emmprin (CD147; basigin) is a cell surface glycoprotein of the immunoglobulin superfamily that is highly up-regulated in malignant cancer cells and stimulates hyaluronan production, as well as several downstream signaling pathways.	Hyaluronic Acid	159-169	basigin (Ok blood group)	Homo sapiens	16-23
19176383-6	2009	In the present study, we find that perturbation of endogenous hyaluronan, using small hyaluronan oligosaccharides, rapidly inhibits lactate efflux from breast carcinoma cells; down-regulation of emmprin, using emmprin small interfering RNA, also results in decreased efflux.	Hyaluronic Acid	62-72	basigin (Ok blood group)	Homo sapiens	195-202
19176383-6	2009	In the present study, we find that perturbation of endogenous hyaluronan, using small hyaluronan oligosaccharides, rapidly inhibits lactate efflux from breast carcinoma cells; down-regulation of emmprin, using emmprin small interfering RNA, also results in decreased efflux.	Hyaluronic Acid	62-72	basigin (Ok blood group)	Homo sapiens	210-217
19176383-8	2009	Moreover, after treatment of the cells with hyaluronan oligosaccharides, CD44, MCT1, and MCT4 become localized intracellularly whereas emmprin remains at the cell membrane.	hyaluronan oligosaccharides	44-71	basigin (Ok blood group)	Homo sapiens	135-142
18778892-3	2009	Our previous results revealed that the over-expressed CD147/basigin plays a critical role in malignant melanoma (MM) invasiveness, metastasis and angiogenesis; CD147 has also been implicated in a specific and strong interaction with monocarboxylate transporters (MCT) 1 and 4 that mediate the transport of lactate.	Lactic Acid	306-313	basigin (Ok blood group)	Homo sapiens	60-67
18778892-3	2009	Our previous results revealed that the over-expressed CD147/basigin plays a critical role in malignant melanoma (MM) invasiveness, metastasis and angiogenesis; CD147 has also been implicated in a specific and strong interaction with monocarboxylate transporters (MCT) 1 and 4 that mediate the transport of lactate.	Lactic Acid	306-313	basigin (Ok blood group)	Homo sapiens	160-165
18778892-4	2009	In the present study, we investigated whether CD147/basigin is involved, via its association with MCT1 and 4 to transport lactate, in glycolysis and then contributes to the progression of A375 melanoma cells.	Lactic Acid	122-129	basigin (Ok blood group)	Homo sapiens	46-51
18778892-4	2009	In the present study, we investigated whether CD147/basigin is involved, via its association with MCT1 and 4 to transport lactate, in glycolysis and then contributes to the progression of A375 melanoma cells.	Lactic Acid	122-129	basigin (Ok blood group)	Homo sapiens	52-59
18778892-7	2009	Furthermore, silencing of CD147/basigin in A375 cells by a siRNA clearly abrogated the expression of MCT1 and 4 and their co-localization with CD147/basigin and dramatically decreased the glycolysis rate, extracellular pH, and the production of ATP.	Adenosine Triphosphate	245-248	basigin (Ok blood group)	Homo sapiens	26-31
18778892-7	2009	Furthermore, silencing of CD147/basigin in A375 cells by a siRNA clearly abrogated the expression of MCT1 and 4 and their co-localization with CD147/basigin and dramatically decreased the glycolysis rate, extracellular pH, and the production of ATP.	Adenosine Triphosphate	245-248	basigin (Ok blood group)	Homo sapiens	32-39
18778892-7	2009	Furthermore, silencing of CD147/basigin in A375 cells by a siRNA clearly abrogated the expression of MCT1 and 4 and their co-localization with CD147/basigin and dramatically decreased the glycolysis rate, extracellular pH, and the production of ATP.	Adenosine Triphosphate	245-248	basigin (Ok blood group)	Homo sapiens	149-156
19636436-8	2009	ATRA treatment downregulates the expression of MT1-MMP, EMMPRIN, FAK, NF-kB, and p-ERK.	Tretinoin	0-4	basigin (Ok blood group)	Homo sapiens	56-63
19636436-13	2009	This inhibitory effect of ATRA on MMP-2 activity in human breast cancer cells (MCF-7) may result due to its inhibitory effect on MT1-MMP, EMMPRIN, and upregulation of TIMP-2.	Tretinoin	26-30	basigin (Ok blood group)	Homo sapiens	138-145
18847500-10	2008	si-CD147 also blocked SMMC-7721 cells adhesion to collagen IV and phosphorylation level of SAPK/JNKs.	smmc	22-26	basigin (Ok blood group)	Homo sapiens	0-8
18761711-2	2008	Basigin, a chaperone protein for specific monocarboxylate transporters (MCTs), represents a putatively important regulatory element for lactate fluxes.	Lactic Acid	136-143	basigin (Ok blood group)	Homo sapiens	0-7
18761711-3	2008	Indeed, basigin knockdown by RNA interference in primary cultures of astrocytes partially reduced both proton-driven lactate influx and efflux.	Lactic Acid	117-124	basigin (Ok blood group)	Homo sapiens	8-15
18761711-4	2008	But more strikingly, enhancement of lactate efflux induced by glutamate was prevented while the effect of sodium azide was significantly reduced by treatment of cultured astrocytes with anti-basigin small interfering RNA.	Lactic Acid	36-43	basigin (Ok blood group)	Homo sapiens	191-198
18761711-4	2008	But more strikingly, enhancement of lactate efflux induced by glutamate was prevented while the effect of sodium azide was significantly reduced by treatment of cultured astrocytes with anti-basigin small interfering RNA.	Sodium Azide	106-118	basigin (Ok blood group)	Homo sapiens	191-198
18761711-8	2008	In contrast, basigin appears to critically regulate the enhancement of lactate release caused by glutamate (or sodium azide) but via an effect on another unidentified transporter at least present in astrocytes in vitro.	Lactic Acid	71-78	basigin (Ok blood group)	Homo sapiens	13-20
18761711-8	2008	In contrast, basigin appears to critically regulate the enhancement of lactate release caused by glutamate (or sodium azide) but via an effect on another unidentified transporter at least present in astrocytes in vitro.	Glutamic Acid	97-106	basigin (Ok blood group)	Homo sapiens	13-20
18761711-8	2008	In contrast, basigin appears to critically regulate the enhancement of lactate release caused by glutamate (or sodium azide) but via an effect on another unidentified transporter at least present in astrocytes in vitro.	Sodium Azide	111-123	basigin (Ok blood group)	Homo sapiens	13-20
18647594-0	2008	Resveratrol inhibits EMMPRIN expression via P38 and ERK1/2 pathways in PMA-induced THP-1 cells.	Resveratrol	0-11	basigin (Ok blood group)	Homo sapiens	21-28
18647594-0	2008	Resveratrol inhibits EMMPRIN expression via P38 and ERK1/2 pathways in PMA-induced THP-1 cells.	Tetradecanoylphorbol Acetate	71-74	basigin (Ok blood group)	Homo sapiens	21-28
18647594-2	2008	EMMPRIN expression is also up-regulated in PMA-induced THP-1 cells and is inhibited by resveratrol.	Resveratrol	87-98	basigin (Ok blood group)	Homo sapiens	0-7
18647594-3	2008	However, it remains unclear how resveratrol inhibits EMMPRIN expression.	Resveratrol	32-43	basigin (Ok blood group)	Homo sapiens	53-60
18647594-4	2008	We thus investigated the role of the MAPK signaling pathway in resveratrol inhibiting the up-regulation of EMMPRIN in PMA-induced THP-1 cells.	Resveratrol	63-74	basigin (Ok blood group)	Homo sapiens	107-114
18647594-6	2008	We also observed that while resveratrol suppresses the up-regulation of EMMPRIN, it also suppresses both the ERK1/2 and p38 pathways in a dose-dependent manner.	Resveratrol	28-39	basigin (Ok blood group)	Homo sapiens	72-79
18647594-7	2008	Taken together, we established that it is through both the ERK1/2 and p38 MAPK pathways that resveratrol inhibits the expression of EMMPRIN in PMA-induced THP-1 cells.	Resveratrol	93-104	basigin (Ok blood group)	Homo sapiens	132-139
17991468-6	2008	Primary structure and biochemical analyses revealed that the parasite"s cyclophilin is defective in heparan binding, an event required for signaling interaction between CD147 and human cyclophilin.	heparan	100-107	basigin (Ok blood group)	Homo sapiens	169-174
18616931-4	2008	CD147 is known to form complex with proton-linked monocarboxylate transporters (MCTs), which is critical for lactate transport and intracellular pH (pHi) homeostasis.	Lactic Acid	109-116	basigin (Ok blood group)	Homo sapiens	0-5
18695939-6	2008	Wortmannin and LY294002, specific phosphatidylinositol kinase (PI3K) inhibitors, reversed the effect of HAb18G/CD147 on the regulation of intracellular Ca(2+) mobilization, significantly reducing cell adhesion, invasion and MMPs secretion potential (p<0.01).	Wortmannin	0-10	basigin (Ok blood group)	Homo sapiens	111-116
18695939-6	2008	Wortmannin and LY294002, specific phosphatidylinositol kinase (PI3K) inhibitors, reversed the effect of HAb18G/CD147 on the regulation of intracellular Ca(2+) mobilization, significantly reducing cell adhesion, invasion and MMPs secretion potential (p<0.01).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	basigin (Ok blood group)	Homo sapiens	111-116
18695939-6	2008	Wortmannin and LY294002, specific phosphatidylinositol kinase (PI3K) inhibitors, reversed the effect of HAb18G/CD147 on the regulation of intracellular Ca(2+) mobilization, significantly reducing cell adhesion, invasion and MMPs secretion potential (p<0.01).	hab18g	104-110	basigin (Ok blood group)	Homo sapiens	111-116
18567920-7	2008	CSA and HAb18G/CD147 antagonistic peptide AP-9 against CD147, respectively, dramatically decreased MMP-2 and MMP-9 expression, both in the absence or presence of CypA.	Cyclosporine	0-3	basigin (Ok blood group)	Homo sapiens	55-60
18774544-3	2008	During our research, CD147 expression in 156 patients who underwent operation for DTC [100 with papillary thyroid carcinoma (PTC) and 56 with follicular thyroid carcinoma (FTC)] were examined by immunostaining on paraffin-embedded tumor specimens.	Paraffin	213-221	basigin (Ok blood group)	Homo sapiens	21-26
18774544-10	2008	Therefore, we conclude that the expression of CD147 may be useful to predict the prognosis of DTC patients.	dtc	94-97	basigin (Ok blood group)	Homo sapiens	46-51
18664479-4	2008	The Spearman correlation was calculated between the expression levels of CD147 and MMP-2 in DTC tissues.	dtc	92-95	basigin (Ok blood group)	Homo sapiens	73-78
18751374-11	2008	In the presence of the broad spectrum MMP inhibitor, GM6001, TN-C deposition by the EMMPRIN overexpressing cocultures was suppressed.	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	53-59	basigin (Ok blood group)	Homo sapiens	84-91
18490190-4	2008	Emmprin, a cell surface glycoprotein of the Ig superfamily, stimulates hyaluronan production and downstream signaling consequences.	Hyaluronic Acid	71-81	basigin (Ok blood group)	Homo sapiens	0-7
17991468-7	2008	When the heparan-binding motif was reconstituted in Leishmania cyclophilin, it regained the CD147-dependent signaling activity.	heparan	9-16	basigin (Ok blood group)	Homo sapiens	92-97
18160397-7	2008	The interference of CD147 with these pathways is highly specific because the overexpression of CD147 does not affect the activity of other GDP/GTP exchange factors or the stimulation of the ERK cascade.	Guanosine Triphosphate	143-146	basigin (Ok blood group)	Homo sapiens	20-25
18281245-0	2008	Selective progesterone receptor modulator asoprisnil down-regulates collagen synthesis in cultured human uterine leiomyoma cells through up-regulating extracellular matrix metalloproteinase inducer.	asoprisnil	42-52	basigin (Ok blood group)	Homo sapiens	151-197
18281245-7	2008	CONCLUSIONS: These results suggest that asoprisnil may reduce collagen deposit in the ECM of cultured leiomyoma cells through decreasing collagen synthesis and enhancing the expression of EMMPRIN, MMPs and TIMPs without comparable effects on cultured myometrial cells.	asoprisnil	40-50	basigin (Ok blood group)	Homo sapiens	188-195
18379211-5	2008	Subsequently, the presence of a mitochondrial lactate oxidation complex (composed of mMCT1, CD147 (basigin), mLDH, and cytochrome oxidase (COX)) was discovered, which lends support to the presence of the ILS.	Lactic Acid	46-53	basigin (Ok blood group)	Homo sapiens	92-97
18315429-0	2008	The effect of adjunctive subantimicrobial dose doxycycline therapy on GCF EMMPRIN levels in chronic periodontitis.	Doxycycline	47-58	basigin (Ok blood group)	Homo sapiens	74-81
18315429-1	2008	BACKGROUND: The aim of the present randomized, double-masked, placebo-controlled, parallel-arm study was to examine the effectiveness of a 3-month regimen of subantimicrobial dose doxycycline (SDD) in combination with scaling and root planing compared to scaling and root planing alone on levels of gingival crevicular fluid (GCF) extracellular matrix metalloproteinase inducer (EMMPRIN) in patients with chronic periodontitis.	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt	193-196	basigin (Ok blood group)	Homo sapiens	379-386
18315429-13	2008	The GCF EMMPRIN level in the SDD group was significantly lower than that of the placebo group at 3 and 6 months (P <0.05).	1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt	29-32	basigin (Ok blood group)	Homo sapiens	8-15
18216291-0	2008	Progesterone receptor modulator CDB-2914 induces extracellular matrix metalloproteinase inducer in cultured human uterine leiomyoma cells.	ulipristal	32-40	basigin (Ok blood group)	Homo sapiens	49-95
18216291-4	2008	In cultured leiomyoma cells, CDB-2914 treatment at concentrations greater than or equal to 10(-8) M significantly increased EMMPRIN, MMP-1 and MMP-8 protein contents and MMP-1, MMP-2, MMP-3 and MMP-9 mRNA levels, and activity of MMP-1, MMP-2, MMP-3 and MMP-9 in the medium.	cdb	29-32	basigin (Ok blood group)	Homo sapiens	124-131
18216291-8	2008	RNAi of EMMPRIN abrogated CDB-2914-mediated both induction of MMPs and reduction of TIMPs and collagens in cultured leiomyoma cells.	ulipristal	26-34	basigin (Ok blood group)	Homo sapiens	8-15
18216291-9	2008	These results suggest that CDB-2914 modulates the expression of EMMPRIN, MMPs, TIMPs and collagens in cultured leiomyoma cells without comparable effects on myometrial cells.	ulipristal	27-35	basigin (Ok blood group)	Homo sapiens	64-71
17483329-2	2007	Recent work has shown that lactate efflux is mediated by monocarboxylate transporters (MCT), which are composed of a catalytic unit (MCT) and an accessory subunit (CD147), comprising the functional lactate transporter.	Lactic Acid	27-34	basigin (Ok blood group)	Homo sapiens	164-169
18048771-8	2008	EMMPRIN is located in the open canalicular system and in alpha granules of platelets (according to electron microscopy and sucrose gradient ultracentrifugation).	Sucrose	123-130	basigin (Ok blood group)	Homo sapiens	0-7
17700972-3	2007	The CD147 antigen consists of two IgSF domains, a transmembrane sequence containing a charged residue (Glu) and a cytoplasmic domain of 40 residues.	Glutamic Acid	103-106	basigin (Ok blood group)	Homo sapiens	4-9
17671123-0	2007	Emmprin and survivin predict response and survival following cisplatin-containing chemotherapy in patients with advanced bladder cancer.	Cisplatin	61-70	basigin (Ok blood group)	Homo sapiens	0-7
17671123-12	2007	CONCLUSIONS: Emmprin and survivin proteins were identified as strong independent prognostic factors for response and survival after cisplatin-containing chemotherapy in patients with advanced bladder cancer.	Cisplatin	132-141	basigin (Ok blood group)	Homo sapiens	13-20
17611393-2	2007	P-gp and CD147/CD98hc complex are both found highly expressed on cisplatin resistant ovarian cancer cell line SKOV3/DDP but only slightly expressed on its parent cell SKOV3.	Cisplatin	65-74	basigin (Ok blood group)	Homo sapiens	9-14
18689982-6	2008	In addition, we found that inhibition of N-glycosylation increased the ubiquitination and degradation of P-gp and CD147, and affected their function.	Nitrogen	41-42	basigin (Ok blood group)	Homo sapiens	114-119
17855358-5	2007	Because the HS binding site extends toward the CypB catalytic pocket, we measured its peptidyl-prolyl cis-trans isomerase (PPIase) activity in the absence or presence of a HS oligosaccharide toward a CD147-derived peptide.	Heparitin Sulfate	12-14	basigin (Ok blood group)	Homo sapiens	200-205
17855358-6	2007	We report the first direct evidence that CypB is enzymatically active on CD147, as it is able to accelerate the cis/trans isomerization of the Asp(179)-Pro(180) bond in a CD147-derived peptide.	Aspartic Acid	143-146	basigin (Ok blood group)	Homo sapiens	73-78
17855358-6	2007	We report the first direct evidence that CypB is enzymatically active on CD147, as it is able to accelerate the cis/trans isomerization of the Asp(179)-Pro(180) bond in a CD147-derived peptide.	Aspartic Acid	143-146	basigin (Ok blood group)	Homo sapiens	171-176
17855358-6	2007	We report the first direct evidence that CypB is enzymatically active on CD147, as it is able to accelerate the cis/trans isomerization of the Asp(179)-Pro(180) bond in a CD147-derived peptide.	Proline	152-155	basigin (Ok blood group)	Homo sapiens	73-78
17855358-6	2007	We report the first direct evidence that CypB is enzymatically active on CD147, as it is able to accelerate the cis/trans isomerization of the Asp(179)-Pro(180) bond in a CD147-derived peptide.	Proline	152-155	basigin (Ok blood group)	Homo sapiens	171-176
17855358-8	2007	We thus conclude that the glycanic moiety of HSPG serves as anchor for CypB at the cell surface, and that the signal could be transduced by CypB via its PPIase activity toward CD147.	glycanic	26-34	basigin (Ok blood group)	Homo sapiens	176-181
17441962-3	2007	Using quantitative real-time polymerase chain reaction and Western blot, we found that overexpression of CD147 in MCF7 cells up-regulated MDR1, MMP2, and MMP9 on both transcription and expression levels, which promoted tumor cells metastasis and conferred them multidrug resistance to P-gp substrate drugs, as determined by in vitro invasion assay and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.	thiazolyl blue	352-412	basigin (Ok blood group)	Homo sapiens	105-110
17441962-3	2007	Using quantitative real-time polymerase chain reaction and Western blot, we found that overexpression of CD147 in MCF7 cells up-regulated MDR1, MMP2, and MMP9 on both transcription and expression levels, which promoted tumor cells metastasis and conferred them multidrug resistance to P-gp substrate drugs, as determined by in vitro invasion assay and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.	monooxyethylene trimethylolpropane tristearate	414-417	basigin (Ok blood group)	Homo sapiens	105-110
17441962-5	2007	Moreover, Erk1/2 in CD147-overexpressing clones were observed to be highly activate and after treatment with U0126, an Erk1/2-specific inhibitor, the expression of MDR1, MMP2 and MMP9 were decreased significantly.	U 0126	109-114	basigin (Ok blood group)	Homo sapiens	20-25
17611393-3	2007	RNAi targeting CD98hc or CD147 both reduce their own and P-gp expression as well as cisplatin IC50 of drug-resistant tumor cells.	Cisplatin	84-93	basigin (Ok blood group)	Homo sapiens	25-30
16860414-3	2007	METHODS AND RESULTS: Through TaqMan real-time RT-PCR and Western blotting, we found the expression of both EMMPRIN mRNA and protein was significantly increased during phorbol 12-myristate 13-acetate (PMA)-induced monocyte differentiation into macrophages.	Tetradecanoylphorbol Acetate	167-198	basigin (Ok blood group)	Homo sapiens	107-114
16860414-3	2007	METHODS AND RESULTS: Through TaqMan real-time RT-PCR and Western blotting, we found the expression of both EMMPRIN mRNA and protein was significantly increased during phorbol 12-myristate 13-acetate (PMA)-induced monocyte differentiation into macrophages.	Tetradecanoylphorbol Acetate	200-203	basigin (Ok blood group)	Homo sapiens	107-114
16860414-5	2007	Both known PPARalpha agonist clofibrate and gamma agonist pioglitazone potently and specifically inhibited EMMPRIN expression in macrophages and foam cells.	Clofibrate	29-39	basigin (Ok blood group)	Homo sapiens	107-114
16860414-5	2007	Both known PPARalpha agonist clofibrate and gamma agonist pioglitazone potently and specifically inhibited EMMPRIN expression in macrophages and foam cells.	Pioglitazone	58-70	basigin (Ok blood group)	Homo sapiens	107-114
16860414-7	2007	In addition, PPARgamma antagonist GW9662 reversed the inhibitory effect of PPARgamma on EMMPRIN protein expression.	2-chloro-5-nitrobenzanilide	34-40	basigin (Ok blood group)	Homo sapiens	88-95
17483329-11	2007	The synergistic activities of the MCT/CD147 complex could facilitate migration of tumor cells by CD147-mediated MMP induction and lactate-stimulated angiogenesis and hyaluronan production.	Lactic Acid	130-137	basigin (Ok blood group)	Homo sapiens	38-43
17483329-11	2007	The synergistic activities of the MCT/CD147 complex could facilitate migration of tumor cells by CD147-mediated MMP induction and lactate-stimulated angiogenesis and hyaluronan production.	Hyaluronic Acid	166-176	basigin (Ok blood group)	Homo sapiens	38-43
17633444-9	2007	VEGFproduction was suppressed when CD147 expression was inhibited by LY294002 or HAb18G mAb.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	basigin (Ok blood group)	Homo sapiens	35-40
17706116-5	2007	After treatment with bleomycin, the expression of CD147 and MMP2 and 9 in both MCF7 and MCF7/AdrR cells remained unchanged (P > 0.05).	Bleomycin	21-30	basigin (Ok blood group)	Homo sapiens	50-55
16930823-0	2007	Inhibition of CD147 gene expression via RNA interference reduces tumor cell invasion, tumorigenicity and increases chemosensitivity to paclitaxel in HO-8910pm cells.	Paclitaxel	135-145	basigin (Ok blood group)	Homo sapiens	14-19
16930823-4	2007	The suppression of CD147 expression also sensitized cells to be more sensitive to paclitaxel.	Paclitaxel	82-92	basigin (Ok blood group)	Homo sapiens	19-24
17706116-6	2007	However, treatment with paclitoxel and vincristine resulted in a remarkable over-expression of CD147 and MMP2 and 9 at both transcription and protein levels in MCF7/AdrR cell line (P < 0.05), while MCF7 cells failed to show similar response.	paclitoxel	24-34	basigin (Ok blood group)	Homo sapiens	95-100
17706116-6	2007	However, treatment with paclitoxel and vincristine resulted in a remarkable over-expression of CD147 and MMP2 and 9 at both transcription and protein levels in MCF7/AdrR cell line (P < 0.05), while MCF7 cells failed to show similar response.	Vincristine	39-50	basigin (Ok blood group)	Homo sapiens	95-100
17488482-5	2007	Monoclonal anti-CD147 antibodies, MEM-M6/1 clone, were able to inhibit protein tyrosine phosphorylation only in CD3 x CD28 costimulated T lymphocytes from SLE patients.	Tyrosine	79-87	basigin (Ok blood group)	Homo sapiens	16-21
17055343-10	2007	In conclusion, resveratrol can down-regulate EMMPRIN expression by macrophages via activating PPARgamma.	Resveratrol	15-26	basigin (Ok blood group)	Homo sapiens	45-52
17055343-0	2007	Resveratrol inhibits macrophage expression of EMMPRIN by activating PPARgamma.	Resveratrol	0-11	basigin (Ok blood group)	Homo sapiens	46-53
17007354-0	2006	[Resveratrol inhibits expression of EMMPRIN from macrophages].	Resveratrol	1-12	basigin (Ok blood group)	Homo sapiens	36-43
17055343-1	2007	The effect of resveratrol on macrophage EMMPRIN expression and its potential mechanism was investigated.	Resveratrol	14-25	basigin (Ok blood group)	Homo sapiens	40-47
17055343-3	2007	Both resveratrol and a PPARgamma agonist, pioglitazone, significantly inhibited EMMPRIN expression and MMP-9 activity in a concentration-dependent manner.	Resveratrol	5-16	basigin (Ok blood group)	Homo sapiens	80-87
17055343-3	2007	Both resveratrol and a PPARgamma agonist, pioglitazone, significantly inhibited EMMPRIN expression and MMP-9 activity in a concentration-dependent manner.	Pioglitazone	42-54	basigin (Ok blood group)	Homo sapiens	80-87
17055343-5	2007	Thus, data suggest that resveratrol may down-regulate EMMPRIN and MMP-9 through PPARgamma activation.	Resveratrol	24-35	basigin (Ok blood group)	Homo sapiens	54-61
16721788-4	2006	Expression and glycosylation state of EMMPRIN in human breast cancer cells were analyzed by Western blot analysis with monoclonal antibodies recognizing distinct carbohydrate structures and biochemical methods.	Carbohydrates	162-174	basigin (Ok blood group)	Homo sapiens	38-45
16721788-9	2006	We could further demonstrate that breast cancer cells expressed EMMPRIN isoforms differing in the presence or absence of Lewis X glycan structures.	Polysaccharides	129-135	basigin (Ok blood group)	Homo sapiens	64-71
16283305-3	2006	TMV showed the presence of several surface determinants of tumour cells, e.g. HLA class I, CD29, CD44v7/8, CD51, chemokine receptors (CCR6, CX3CR1), extracellular matrix metalloproteinase inducer (EMMPRIN), epithelial cell adhesion molecule (EpCAM), but their level of expression differed from that on cells they originated from.	tmv	0-3	basigin (Ok blood group)	Homo sapiens	149-195
16283305-3	2006	TMV showed the presence of several surface determinants of tumour cells, e.g. HLA class I, CD29, CD44v7/8, CD51, chemokine receptors (CCR6, CX3CR1), extracellular matrix metalloproteinase inducer (EMMPRIN), epithelial cell adhesion molecule (EpCAM), but their level of expression differed from that on cells they originated from.	tmv	0-3	basigin (Ok blood group)	Homo sapiens	197-204
17007354-8	2006	Both resveratrol and pioglitazone markedly inhibited EMMPRIN expression during monocytes differentiation.	Resveratrol	5-16	basigin (Ok blood group)	Homo sapiens	53-60
17007354-8	2006	Both resveratrol and pioglitazone markedly inhibited EMMPRIN expression during monocytes differentiation.	Pioglitazone	21-33	basigin (Ok blood group)	Homo sapiens	53-60
17007354-9	2006	Resveratrol significantly activated PPARgamma and GW9662 greatly decreased the effect of resveratrol on EMMPRIN and MMP-9.	2-chloro-5-nitrobenzanilide	50-56	basigin (Ok blood group)	Homo sapiens	104-111
17007354-1	2006	AIM: To investigate the effect of resveratrol on EMMPRIN expression of macrophages.	Resveratrol	34-45	basigin (Ok blood group)	Homo sapiens	49-56
17007354-9	2006	Resveratrol significantly activated PPARgamma and GW9662 greatly decreased the effect of resveratrol on EMMPRIN and MMP-9.	Resveratrol	89-100	basigin (Ok blood group)	Homo sapiens	104-111
16778084-6	2006	Furthermore, the PI3K-specific inhibitor LY294002 inhibited VEGF production by EMMPRIN-overexpressing cells in a dose- and time-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	41-49	basigin (Ok blood group)	Homo sapiens	79-86
17007354-11	2006	Resveratrol can significantly inhibit EMMPRIN expression via activating PPARgamma, which may be the underlying mechanism of its inhibitory effect on MMPs production by monocytes/macrophages.	Resveratrol	0-11	basigin (Ok blood group)	Homo sapiens	38-45
16643793-1	2006	AIM: To investigate the expression of CD147 both on cellular membrane and in culture supernatant of in vitro cultured THP-1 cells and monocytes of RA patients before and after stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	193-218	basigin (Ok blood group)	Homo sapiens	38-43
16643793-1	2006	AIM: To investigate the expression of CD147 both on cellular membrane and in culture supernatant of in vitro cultured THP-1 cells and monocytes of RA patients before and after stimulation with phorbol myristate acetate (PMA).	Tetradecanoylphorbol Acetate	220-223	basigin (Ok blood group)	Homo sapiens	38-43
16182316-8	2006	Fluvastatin blocked the CRP-induced increases in EMMPRIN and MMP-9 expression and activity.	Fluvastatin	0-11	basigin (Ok blood group)	Homo sapiens	49-56
15901826-6	2005	Our data point to a CD147-CD98 cell surface supercomplex that plays a critical role in energy metabolism, likely by coordinating transport of lactate and amino acids.	Lactic Acid	142-149	basigin (Ok blood group)	Homo sapiens	20-25
16824781-8	2006	Furthermore, the results of endoglycosidases treatment also showed that two forms of HAb18G/CD147 contain different types of oligosaccharide chains, thus sensitive to different endoglycosidase.	Oligosaccharides	125-140	basigin (Ok blood group)	Homo sapiens	92-97
16260747-1	2005	Proton-coupled monocarboxylate transporters (MCT) MCT1, MCT3, and MCT4 form heterodimeric complexes with the cell surface glycoprotein CD147 and exhibit tissue-specific polarized distributions that are essential for maintaining lactate and pH homeostasis.	Lactic Acid	228-235	basigin (Ok blood group)	Homo sapiens	135-140
16260747-2	2005	In the parenchymal epithelia of kidney, thyroid, and liver, MCT/CD147 heterocomplexes are localized in the basolateral membrane where they transport lactate out of or into the cell depending on metabolic conditions.	Lactic Acid	149-156	basigin (Ok blood group)	Homo sapiens	64-69
16176007-2	2005	METHOD: The expressions of EMMPRIN were detected by the method of immunohistochemical SP in 42 specimens taken from the patients with laryngeal squamous cell carcinoma, 28 specimens from precancerous lesion and 20 specimens from normal laryngeal tissues.	TFF2 protein, human	86-88	basigin (Ok blood group)	Homo sapiens	27-34
15632176-5	2005	On the other hand, increasing hyaluronan production by overexpression of hyaluronan synthase 2 or emmprin causes elevated ErbB2 phosphorylation in MCF-7 mammary carcinoma cells, which normally exhibit low levels of ErbB2 activity.	Hyaluronic Acid	30-40	basigin (Ok blood group)	Homo sapiens	98-105
15904490-5	2005	After 24 hours of PMA-induced monocyte differentiation, the mean fluorescence intensity of CD147 in differentiated THP-1 cells (289.61 +/- 31.63) was higher than that of the undifferentiated THP-1 cells (205.1 +/- 19.25).	Tetradecanoylphorbol Acetate	18-21	basigin (Ok blood group)	Homo sapiens	91-96
15671024-0	2005	Regulation of CD147 cell surface expression: involvement of the proline residue in the CD147 transmembrane domain.	Proline	64-71	basigin (Ok blood group)	Homo sapiens	14-19
15671024-0	2005	Regulation of CD147 cell surface expression: involvement of the proline residue in the CD147 transmembrane domain.	Proline	64-71	basigin (Ok blood group)	Homo sapiens	87-92
15671024-4	2005	Treatment with cyclosporin A significantly reduced surface expression of CD147 and of CD8-CD147 fusion protein carrying the extracellular domain of CD8 fused to the transmembrane and cytoplasmic domains of CD147, but did not affect expression of CD8.	Cyclosporine	15-28	basigin (Ok blood group)	Homo sapiens	73-78
15671024-4	2005	Treatment with cyclosporin A significantly reduced surface expression of CD147 and of CD8-CD147 fusion protein carrying the extracellular domain of CD8 fused to the transmembrane and cytoplasmic domains of CD147, but did not affect expression of CD8.	Cyclosporine	15-28	basigin (Ok blood group)	Homo sapiens	90-95
15671024-4	2005	Treatment with cyclosporin A significantly reduced surface expression of CD147 and of CD8-CD147 fusion protein carrying the extracellular domain of CD8 fused to the transmembrane and cytoplasmic domains of CD147, but did not affect expression of CD8.	Cyclosporine	15-28	basigin (Ok blood group)	Homo sapiens	90-95
15671024-5	2005	Peptide binding studies demonstrated specific interaction between CypA and the proline-containing peptide from the CD147 transmembrane domain.	Proline	79-86	basigin (Ok blood group)	Homo sapiens	115-120
15671024-6	2005	Mutation of this proline residue reduced binding of CD147-derived peptides to CypA and also diminished transport of CD147 to the plasma membrane without reducing the total level of CD147 expression.	Proline	17-24	basigin (Ok blood group)	Homo sapiens	52-57
15671024-6	2005	Mutation of this proline residue reduced binding of CD147-derived peptides to CypA and also diminished transport of CD147 to the plasma membrane without reducing the total level of CD147 expression.	Proline	17-24	basigin (Ok blood group)	Homo sapiens	116-121
15671024-6	2005	Mutation of this proline residue reduced binding of CD147-derived peptides to CypA and also diminished transport of CD147 to the plasma membrane without reducing the total level of CD147 expression.	Proline	17-24	basigin (Ok blood group)	Homo sapiens	116-121
15841317-5	2005	E-LDL in contrast to n-LDL induced substantial activation of the plasminogen activation system as well as of the MMP system in monocytic cells, as measured by enhanced cell surface expression of the urokinase receptor (uPAR),the extracellular matrix metalloproteinase Inducer (EMMPRIN) and the membrane type-1 MMPs (MT1-MMP,MMP-14), as well as by secretion of active uPA, and of MMP-9.	e-ldl	0-5	basigin (Ok blood group)	Homo sapiens	277-284
15185339-9	2004	It was suggested that G-Gly increased the number of vesicles containing MMP-1 and that MMP-1 interacted with CD147 to increase invasion.	g-gly	22-27	basigin (Ok blood group)	Homo sapiens	109-114
15711733-5	2005	Emmprin induces angiogenesis via stimulation of VEGF production, invasiveness via stimulation of matrix metalloproteinase production and multidrug resistance via hyaluronan-mediated up-regulation of ErbB2 signaling and cell survival pathway activities.	Hyaluronic Acid	162-172	basigin (Ok blood group)	Homo sapiens	0-7
15215314-7	2004	Four amino acids (243-246) N-terminal to leucine 252 are also critical basolateral determinants of CD147, because deletion of these amino acids leads to mistargeting of CD147 to the apical membranes.	Leucine	41-48	basigin (Ok blood group)	Homo sapiens	169-174
15680395-9	2005	HAoSMCs expressed much higher CD147 and neuropilin-1 (NRP-1) mRNA than HMVECs-L and HCAECs (P < 0.017, ANOVA).	haosmcs	0-7	basigin (Ok blood group)	Homo sapiens	30-35
15201341-3	2004	l-Phytohemagglutinin lectin binding and swainsonine inhibition experiments indicated that HG-CD147 contains N-acetylglucosaminyltransferase V-catalyzed, beta1,6-branched, polylactosamine-type sugars, which account for its excess size.	Swainsonine	40-51	basigin (Ok blood group)	Homo sapiens	93-98
15201341-3	2004	l-Phytohemagglutinin lectin binding and swainsonine inhibition experiments indicated that HG-CD147 contains N-acetylglucosaminyltransferase V-catalyzed, beta1,6-branched, polylactosamine-type sugars, which account for its excess size.	beta1,6-branched, polylactosamine	153-186	basigin (Ok blood group)	Homo sapiens	93-98
15201341-3	2004	l-Phytohemagglutinin lectin binding and swainsonine inhibition experiments indicated that HG-CD147 contains N-acetylglucosaminyltransferase V-catalyzed, beta1,6-branched, polylactosamine-type sugars, which account for its excess size.	Sugars	192-198	basigin (Ok blood group)	Homo sapiens	93-98
15201341-4	2004	Therefore, CD147, which is itself elevated on invasive tumor cells, may make a major contribution to the abundance of beta1,6-branched polylactosamine sugars that appear on invasive tumor cells.	beta1,6-branched polylactosamine sugars	118-157	basigin (Ok blood group)	Homo sapiens	11-16
15201341-7	2004	In conclusion, we have 1) determined the biochemical basis for the unusual size variation in CD147, 2) established that CD147 is a major carrier of beta1,6-branched polylactosamine sugars on tumor cells, and 3) determined that caveolin-1 can inhibit the conversion of LG-CD147 to HG-CD147.	beta1,6-branched polylactosamine sugars	148-187	basigin (Ok blood group)	Homo sapiens	120-125
15201341-7	2004	In conclusion, we have 1) determined the biochemical basis for the unusual size variation in CD147, 2) established that CD147 is a major carrier of beta1,6-branched polylactosamine sugars on tumor cells, and 3) determined that caveolin-1 can inhibit the conversion of LG-CD147 to HG-CD147.	beta1,6-branched polylactosamine sugars	148-187	basigin (Ok blood group)	Homo sapiens	120-125
15201341-7	2004	In conclusion, we have 1) determined the biochemical basis for the unusual size variation in CD147, 2) established that CD147 is a major carrier of beta1,6-branched polylactosamine sugars on tumor cells, and 3) determined that caveolin-1 can inhibit the conversion of LG-CD147 to HG-CD147.	beta1,6-branched polylactosamine sugars	148-187	basigin (Ok blood group)	Homo sapiens	120-125
15215314-4	2004	The cytoplasmic domain of CD147 has basolateral sorting information but is devoid of well-characterized basolateral signals, such as tyrosine and di-leucine motifs.	Tyrosine	133-141	basigin (Ok blood group)	Homo sapiens	26-31
15215314-4	2004	The cytoplasmic domain of CD147 has basolateral sorting information but is devoid of well-characterized basolateral signals, such as tyrosine and di-leucine motifs.	di-leucine	146-156	basigin (Ok blood group)	Homo sapiens	26-31
15215314-7	2004	Four amino acids (243-246) N-terminal to leucine 252 are also critical basolateral determinants of CD147, because deletion of these amino acids leads to mistargeting of CD147 to the apical membranes.	Leucine	41-48	basigin (Ok blood group)	Homo sapiens	99-104
14983875-0	2004	Emmprin promotes anchorage-independent growth in human mammary carcinoma cells by stimulating hyaluronan production.	Hyaluronic Acid	94-104	basigin (Ok blood group)	Homo sapiens	0-7
14707126-2	2004	CD147-caveolin-1 complex formation was temperature and cholesterol dependent, reminiscent of associations seen within caveolae/lipid rafts.	Cholesterol	55-66	basigin (Ok blood group)	Homo sapiens	0-5
14707126-3	2004	However, the subset of caveolin-1 associated with CD147 appeared exclusively within intermediate density sucrose gradient fractions, rather than in the low density fractions containing the bulk of caveolin-1.	Sucrose	105-112	basigin (Ok blood group)	Homo sapiens	50-55
15316657-0	2004	HAb18G/CD147-mediated calcium mobilization and hepatoma metastasis require both C-terminal and N-terminal domains.	Calcium	22-29	basigin (Ok blood group)	Homo sapiens	7-12
15316657-2	2004	Our previous studies have indicated that overexpression of HAb18G/CD147 enhances metastatic potentials in human hepatoma cells by disrupting the regulation of store-operated Ca2+ entry by nitric oxide (NO)/cGMP.	Nitric Oxide	188-200	basigin (Ok blood group)	Homo sapiens	66-71
15316657-2	2004	Our previous studies have indicated that overexpression of HAb18G/CD147 enhances metastatic potentials in human hepatoma cells by disrupting the regulation of store-operated Ca2+ entry by nitric oxide (NO)/cGMP.	Cyclic GMP	206-210	basigin (Ok blood group)	Homo sapiens	66-71
15316657-4	2004	The inhibitory effect of HAb18G/CD147 on 8-bromo-cGMP-regulated thapsigargin-induced Ca2+ entry was reversed by the expression of either C or N terminus truncated HAb18G/CD147 in T7721deltaC and T7721deltaN cells, respectively.	hab18g	25-31	basigin (Ok blood group)	Homo sapiens	170-175
15316657-4	2004	The inhibitory effect of HAb18G/CD147 on 8-bromo-cGMP-regulated thapsigargin-induced Ca2+ entry was reversed by the expression of either C or N terminus truncated HAb18G/CD147 in T7721deltaC and T7721deltaN cells, respectively.	8-bromocyclic GMP	41-53	basigin (Ok blood group)	Homo sapiens	32-37
15316657-4	2004	The inhibitory effect of HAb18G/CD147 on 8-bromo-cGMP-regulated thapsigargin-induced Ca2+ entry was reversed by the expression of either C or N terminus truncated HAb18G/CD147 in T7721deltaC and T7721deltaN cells, respectively.	8-bromocyclic GMP	41-53	basigin (Ok blood group)	Homo sapiens	170-175
15316657-4	2004	The inhibitory effect of HAb18G/CD147 on 8-bromo-cGMP-regulated thapsigargin-induced Ca2+ entry was reversed by the expression of either C or N terminus truncated HAb18G/CD147 in T7721deltaC and T7721deltaN cells, respectively.	Thapsigargin	64-76	basigin (Ok blood group)	Homo sapiens	32-37
15316657-4	2004	The inhibitory effect of HAb18G/CD147 on 8-bromo-cGMP-regulated thapsigargin-induced Ca2+ entry was reversed by the expression of either C or N terminus truncated HAb18G/CD147 in T7721deltaC and T7721deltaN cells, respectively.	Thapsigargin	64-76	basigin (Ok blood group)	Homo sapiens	170-175
15316657-4	2004	The inhibitory effect of HAb18G/CD147 on 8-bromo-cGMP-regulated thapsigargin-induced Ca2+ entry was reversed by the expression of either C or N terminus truncated HAb18G/CD147 in T7721deltaC and T7721deltaN cells, respectively.	hab18g	163-169	basigin (Ok blood group)	Homo sapiens	32-37
15316657-9	2004	Taken together, these results suggest that both ectodomain and intracellular domains of HAb18G/CD147 are required to mediate the effect of HAb18G/CD147 on the secretion and activation of MMPs and metastasis-related processes in human hepatoma cells by disrupting the regulation of NO/cGMP-sensitive intracellular Ca2+ mobilization although each domain may play different roles.	Cyclic GMP	284-288	basigin (Ok blood group)	Homo sapiens	95-100
15316657-9	2004	Taken together, these results suggest that both ectodomain and intracellular domains of HAb18G/CD147 are required to mediate the effect of HAb18G/CD147 on the secretion and activation of MMPs and metastasis-related processes in human hepatoma cells by disrupting the regulation of NO/cGMP-sensitive intracellular Ca2+ mobilization although each domain may play different roles.	Cyclic GMP	284-288	basigin (Ok blood group)	Homo sapiens	146-151
14983875-4	2004	We also found that elevated emmprin expression stimulates hyaluronan production and that the effect of emmprin on anchorage-independent growth is dependent on hyaluronan.	Hyaluronic Acid	58-68	basigin (Ok blood group)	Homo sapiens	28-35
14983875-4	2004	We also found that elevated emmprin expression stimulates hyaluronan production and that the effect of emmprin on anchorage-independent growth is dependent on hyaluronan.	Hyaluronic Acid	159-169	basigin (Ok blood group)	Homo sapiens	103-110
14983875-5	2004	Furthermore, emmprin stimulates cell survival pathway signaling in a hyaluronan-dependent manner.	Hyaluronic Acid	69-79	basigin (Ok blood group)	Homo sapiens	13-20
14706635-4	2004	Similarly, flow cytometric analysis exhibited that cynaropicrin down-regulated strikingly surface level of CD29 and CD147, a functional regulator of CD98, but not CD43.	cynaropicrin	51-63	basigin (Ok blood group)	Homo sapiens	116-121
14671212-10	2003	The production and glycosylation of EMMPRIN in the stromal cells were augmented by progesterone at the posttranscriptional and posttranslational stages, respectively.	Progesterone	83-95	basigin (Ok blood group)	Homo sapiens	36-43
14671212-11	2003	These results suggest for the first time that EMMPRIN is expressed in human endometrium during the menstrual cycle and that its expression and glycosylation are augmented by progesterone.	Progesterone	174-186	basigin (Ok blood group)	Homo sapiens	46-53
14562372-4	2003	Expression of HAb18G/CD147 of transfected cells selected by G418 (geneticin) was observed by immuno-histochemical SP staining and FACS (fluorescence activated cell sorting).	antibiotic G 418	60-64	basigin (Ok blood group)	Homo sapiens	21-26
14606962-7	2003	CONCLUSION: The finding that the three domain form of CD147 has an extracellular ligand, that is it interacts homophilically, suggests this interaction may be important in aligning lactate transporters in the retina where lactate is an important metabolite.	Lactic Acid	181-188	basigin (Ok blood group)	Homo sapiens	54-59
14613643-4	2003	METHODS: The expression of EMMPRIN was examined in 45 bladder carcinoma tissues from 45 patients and normal bladder mucosa from 9 persons by immunohistochemistry SP method.	TFF2 protein, human	162-164	basigin (Ok blood group)	Homo sapiens	27-34
14562372-4	2003	Expression of HAb18G/CD147 of transfected cells selected by G418 (geneticin) was observed by immuno-histochemical SP staining and FACS (fluorescence activated cell sorting).	TFF2 protein, human	114-116	basigin (Ok blood group)	Homo sapiens	21-26
12719975-0	2003	Correlation of emmprin expression in vascular endothelial cells with blood-brain-barrier function: a study using magnetic resonance imaging enhanced by Gd-DTPA and immunohistochemistry in brain tumors.	Gadolinium DTPA	152-159	basigin (Ok blood group)	Homo sapiens	15-22
12898514-11	2003	There was a great significance (P < 0.05) of EMMPRIN expression between stage I & II and stage III GCTs.	Adenosine Monophosphate	84-87	basigin (Ok blood group)	Homo sapiens	48-55
12738783-5	2003	Likewise, increased expression of emmprin, which is a glycoprotein that is present on the surface of most malignant cancer cells and that stimulates hyaluronan production, also induces increased resistance.	Hyaluronic Acid	149-159	basigin (Ok blood group)	Homo sapiens	34-41
12902469-3	2003	Triggering CD147 induces a displacement of the GPI-anchored coreceptors CD48 and CD59 from microdomains in human T lymphocytes.	Glycosylphosphatidylinositols	47-50	basigin (Ok blood group)	Homo sapiens	11-16
12719975-7	2003	The tissues from Gd-DTPA-enhanced or non-enhanced areas were processed into frozen sections and subjected to immunohistochemistry with anti-emmprin antibody.	Gadolinium DTPA	17-24	basigin (Ok blood group)	Homo sapiens	140-147
12719975-8	2003	The expression of emmprin in brain vascular endothelial cells inversely correlated with Gd-DTPA-enhancement of MRI: emmprin was positive in tissues not enhanced by Gd-DTPA and was negative in DTPA-enhanced tissues.	Gadolinium DTPA	88-95	basigin (Ok blood group)	Homo sapiens	18-25
12719975-8	2003	The expression of emmprin in brain vascular endothelial cells inversely correlated with Gd-DTPA-enhancement of MRI: emmprin was positive in tissues not enhanced by Gd-DTPA and was negative in DTPA-enhanced tissues.	Gadolinium DTPA	164-171	basigin (Ok blood group)	Homo sapiens	18-25
12719975-8	2003	The expression of emmprin in brain vascular endothelial cells inversely correlated with Gd-DTPA-enhancement of MRI: emmprin was positive in tissues not enhanced by Gd-DTPA and was negative in DTPA-enhanced tissues.	Gadolinium DTPA	164-171	basigin (Ok blood group)	Homo sapiens	116-123
12719975-8	2003	The expression of emmprin in brain vascular endothelial cells inversely correlated with Gd-DTPA-enhancement of MRI: emmprin was positive in tissues not enhanced by Gd-DTPA and was negative in DTPA-enhanced tissues.	Pentetic Acid	91-95	basigin (Ok blood group)	Homo sapiens	18-25
12034734-0	2002	Luminal leptin enhances CD147/MCT-1-mediated uptake of butyrate in the human intestinal cell line Caco2-BBE.	Butyrates	55-63	basigin (Ok blood group)	Homo sapiens	24-29
12034734-0	2002	Luminal leptin enhances CD147/MCT-1-mediated uptake of butyrate in the human intestinal cell line Caco2-BBE.	caco2-bbe	98-107	basigin (Ok blood group)	Homo sapiens	24-29
12034734-5	2002	We show that MCT-1 associates with CD147 at the apical plasma membrane in Caco2-BBE cell monolayers.	caco2-bbe	74-83	basigin (Ok blood group)	Homo sapiens	35-40
12034734-6	2002	Using antisense CD147, we demonstrate that the association of CD147 with MCT-1 is critical for the butyrate transport activity.	Butyrates	99-107	basigin (Ok blood group)	Homo sapiens	16-21
12034734-6	2002	Using antisense CD147, we demonstrate that the association of CD147 with MCT-1 is critical for the butyrate transport activity.	Butyrates	99-107	basigin (Ok blood group)	Homo sapiens	62-67
12034734-7	2002	Interestingly, we show for the first time hormonal regulation of CD147/MCT-1 mediated butyrate uptake.	Butyrates	86-94	basigin (Ok blood group)	Homo sapiens	65-70
11943775-6	2002	The proline 180 and glycine 181 residues in the extracellular domain of CD147 were critical for signaling and chemotactic activities mediated by CD147.	Proline	4-11	basigin (Ok blood group)	Homo sapiens	72-77
11943775-6	2002	The proline 180 and glycine 181 residues in the extracellular domain of CD147 were critical for signaling and chemotactic activities mediated by CD147.	Proline	4-11	basigin (Ok blood group)	Homo sapiens	145-150
11943775-6	2002	The proline 180 and glycine 181 residues in the extracellular domain of CD147 were critical for signaling and chemotactic activities mediated by CD147.	Glycine	20-27	basigin (Ok blood group)	Homo sapiens	72-77
11943775-6	2002	The proline 180 and glycine 181 residues in the extracellular domain of CD147 were critical for signaling and chemotactic activities mediated by CD147.	Glycine	20-27	basigin (Ok blood group)	Homo sapiens	145-150
11421350-7	2000	Basigin and embigin, two related members of the immunoglobulin superfamily, a sialomucin MGC-24 and other glycoproteins were discovered as carriers of developmentally regulated carbohydrate markers.	Carbohydrates	177-189	basigin (Ok blood group)	Homo sapiens	0-7
11591720-0	2001	The involvement of HAb18G/CD147 in regulation of store-operated calcium entry and metastasis of human hepatoma cells.	Calcium	64-71	basigin (Ok blood group)	Homo sapiens	26-31
11591720-1	2001	The present study examined the effect of hepatoma-associated antigen HAb18G (homologous to CD147) expression on the NO/cGMP-regulated Ca(2+) mobilization and metastatic process of human hepatoma cells.	Cyclic GMP	119-123	basigin (Ok blood group)	Homo sapiens	91-96
11591720-5	2001	However, expression of HAb18G/CD147 in T7721 cells decreased the inhibitory response to cGMP.	Cyclic GMP	88-92	basigin (Ok blood group)	Homo sapiens	30-35
11591720-7	2001	The inhibitory effect of SNAP on the thapsigargin-induced Ca(2+) entry was significantly reduced in HAb18G/CD147-expressing T7721 cells, indicating a role for HAb18G/CD147 in NO/cGMP-regulated Ca(2+) entry.	Thapsigargin	37-49	basigin (Ok blood group)	Homo sapiens	107-112
11591720-7	2001	The inhibitory effect of SNAP on the thapsigargin-induced Ca(2+) entry was significantly reduced in HAb18G/CD147-expressing T7721 cells, indicating a role for HAb18G/CD147 in NO/cGMP-regulated Ca(2+) entry.	Thapsigargin	37-49	basigin (Ok blood group)	Homo sapiens	166-171
11435306-9	2001	Unexpectedly, 2 antibodies to CD147, an immunoglobulin superfamily member whose function has remained unclear, were also potent inhibitors of both the aggregation and the protein tyrosine phosphorylation induced via CD98 ligation.	Tyrosine	179-187	basigin (Ok blood group)	Homo sapiens	30-35
11943706-7	2002	We find that the periodic acid-Schiff-diastase-resistant cytoplasmic granules of ASPS are strongly immunoreactive for MCT1 and CD147.	Periodic Acid	17-30	basigin (Ok blood group)	Homo sapiens	127-132
11591720-12	2001	These results suggest that HAb18G/CD147 enhances metastatic potentials in human hepatoma cells by disrupting the regulation of store-operated Ca(2+) entry by NO/cGMP.	Cyclic GMP	161-165	basigin (Ok blood group)	Homo sapiens	34-39
11567989-0	2001	Treatment of steroid-refractory acute graft-versus-host disease with anti-CD147 monoclonal antibody ABX-CBL.	Steroids	13-20	basigin (Ok blood group)	Homo sapiens	74-79
11683705-4	2001	In the normal adult testes, basigin was detected at the periphery of both spermatocytes older than zygotene and round spermatids.	zygotene	99-107	basigin (Ok blood group)	Homo sapiens	28-35
11402500-4	2001	The results indicated that a PKC inhibitor, sphingosine, and a PTK inhibitor, herbimycin A, inhibited CD147 mAb-induced cell aggregation in a dose-dependent manner.	Sphingosine	44-55	basigin (Ok blood group)	Homo sapiens	102-107
11402500-4	2001	The results indicated that a PKC inhibitor, sphingosine, and a PTK inhibitor, herbimycin A, inhibited CD147 mAb-induced cell aggregation in a dose-dependent manner.	herbimycin	78-90	basigin (Ok blood group)	Homo sapiens	102-107
11402500-7	2001	Effect of actin filament polymerization blocking agent, cytochalasin B, was also studied and it was found that cytochalasin B completely inhibited CD147 mAb-induced cell aggregation.	Cytochalasin B	111-125	basigin (Ok blood group)	Homo sapiens	147-152
10921872-2	2000	Here we use co-immunoprecipitation and chemical cross-linking to demonstrate that CD147 specifically interacts with MCT1 and MCT4, two members of the proton-linked monocarboxylate (lactate) transporter family that play a fundamental role in metabolism, but not with MCT2.	Lactic Acid	181-188	basigin (Ok blood group)	Homo sapiens	82-87
1846736-1	1991	A tumor cell-derived, collagenase stimulatory factor (TCSF), previously isolated and purified from LX-1 human lung carcinoma cells and judged by immunoblotting and SDS-PAGE to contain a single protein of approximately 58 kDa, has been further analyzed for its biological activity and composition.	Sodium Dodecyl Sulfate	164-167	basigin (Ok blood group)	Homo sapiens	2-52
10880960-5	2000	If the disulfide bond of the more N-terminally located Ig-like domain was destroyed by mutations, Bsg could not form oligomers.	Disulfides	7-16	basigin (Ok blood group)	Homo sapiens	98-101
10233694-8	1999	The U937 cell aggregation induced by CD147 mAb was also inhibited by ethylenediamine tetra-acetic acid (EDTA), sodium azide and when incubated at 4 degrees.	Edetic Acid	104-108	basigin (Ok blood group)	Homo sapiens	37-42
10233694-8	1999	The U937 cell aggregation induced by CD147 mAb was also inhibited by ethylenediamine tetra-acetic acid (EDTA), sodium azide and when incubated at 4 degrees.	Sodium Azide	111-123	basigin (Ok blood group)	Homo sapiens	37-42
7511628-7	1994	Reduction of TcsF with DTT followed by alkylation with methylmethanethiosulfonate (MMTS), demonstrated that the active subunit of TcsF bound to and eluted from anti-TCR-alpha, but not to anti-TCR-beta columns.	Dithiothreitol	23-26	basigin (Ok blood group)	Homo sapiens	13-17
7511628-7	1994	Reduction of TcsF with DTT followed by alkylation with methylmethanethiosulfonate (MMTS), demonstrated that the active subunit of TcsF bound to and eluted from anti-TCR-alpha, but not to anti-TCR-beta columns.	Dithiothreitol	23-26	basigin (Ok blood group)	Homo sapiens	130-134
7511628-7	1994	Reduction of TcsF with DTT followed by alkylation with methylmethanethiosulfonate (MMTS), demonstrated that the active subunit of TcsF bound to and eluted from anti-TCR-alpha, but not to anti-TCR-beta columns.	methyl methanethiosulfonate	55-81	basigin (Ok blood group)	Homo sapiens	130-134
7511628-7	1994	Reduction of TcsF with DTT followed by alkylation with methylmethanethiosulfonate (MMTS), demonstrated that the active subunit of TcsF bound to and eluted from anti-TCR-alpha, but not to anti-TCR-beta columns.	methyl methanethiosulfonate	83-87	basigin (Ok blood group)	Homo sapiens	130-134
7511628-8	1994	The active TcsF that bound to anti-TCR-alpha but not to the anti-TCR-beta column was shown subsequently to have the ability to bind to specific Ag columns TNP-BSA and TNP-BGG Sepharose 4B.	Sepharose	175-184	basigin (Ok blood group)	Homo sapiens	11-15
7511628-10	1994	Separation of TcsF on SDS-PAGE under reducing conditions, followed by elution and renaturation of proteins from the gel slices, showed that a 35 to 40 kDa protein had the T cell contrasuppressive activity.	Sodium Dodecyl Sulfate	22-25	basigin (Ok blood group)	Homo sapiens	14-18
7511628-14	1994	SDS-PAGE analysis under reducing conditions suggested a molecular weight of about 35 to 40 kDa for the TNP-specific TcsF.	Sodium Dodecyl Sulfate	0-3	basigin (Ok blood group)	Homo sapiens	116-120
9877171-5	1998	In vitro, EMMPRIN upregulates MMP-1 mRNA expression in a concentration-dependent manner, with a peak accumulation at 24 h. The response is genistein-sensitive, suggesting it is dependent on tyrosine kinase activity.	Genistein	139-148	basigin (Ok blood group)	Homo sapiens	10-17
9877171-6	1998	Analysis of tyrosine phosphorylation-dependent MAP kinases ERK 1/2, SAPK/JNK, and p38 showed that the activity of p38 but not that of the other 2 kinases was elevated in response to EMMPRIN.	Tyrosine	12-20	basigin (Ok blood group)	Homo sapiens	182-189
9877171-7	1998	That p38 activity was required for EMMPRIN stimulation of MMP-1 was evident from results showing that the p38 inhibitor SB203580 blocked this response.	SB 203580	120-128	basigin (Ok blood group)	Homo sapiens	35-42
1846736-1	1991	A tumor cell-derived, collagenase stimulatory factor (TCSF), previously isolated and purified from LX-1 human lung carcinoma cells and judged by immunoblotting and SDS-PAGE to contain a single protein of approximately 58 kDa, has been further analyzed for its biological activity and composition.	Sodium Dodecyl Sulfate	164-167	basigin (Ok blood group)	Homo sapiens	54-58
33770122-0	2021	Basigin drives intracellular accumulation of l-lactate by harvesting protons and substrate anions.	L-lactate	45-54	basigin (Ok blood group)	Homo sapiens	0-7
33770122-4	2021	Here, we show that the presence of basigin leads to an intracellular accumulation of l-lactate 4.5-fold above the substrate/proton concentrations provided by the external buffer.	L-lactate	85-94	basigin (Ok blood group)	Homo sapiens	35-42
33770122-7	2021	From these data, and determinations of the cytosolic pH with a fluorescent probe, we conclude that the basigin Ig-I domain drives lactate uptake by locally increasing the proton and substrate concentration at the extracellular MCT entry site.	Lactic Acid	130-137	basigin (Ok blood group)	Homo sapiens	103-110
33770122-10	2021	Tumor progression according to classical or reverse Warburg effects depends on the transmembrane l-lactate distribution, and this study shows that the basigin Ig-I domain is a pivotal determinant.	L-lactate	97-106	basigin (Ok blood group)	Homo sapiens	151-158
33766713-8	2021	The adjusted hazard ratio for NAC treated versus no-NAC was 0.42 (95% CI: 0.27-0.64) for patients with negative CCTalpha expression, when adding information about emmprin it decreased to 0.33 (95% CI: 0.19-0.56) for patients with both negative CCTalpha and emmprin.	nac	30-33	basigin (Ok blood group)	Homo sapiens	163-170
33766713-8	2021	The adjusted hazard ratio for NAC treated versus no-NAC was 0.42 (95% CI: 0.27-0.64) for patients with negative CCTalpha expression, when adding information about emmprin it decreased to 0.33 (95% CI: 0.19-0.56) for patients with both negative CCTalpha and emmprin.	nac	30-33	basigin (Ok blood group)	Homo sapiens	257-264
33766713-8	2021	The adjusted hazard ratio for NAC treated versus no-NAC was 0.42 (95% CI: 0.27-0.64) for patients with negative CCTalpha expression, when adding information about emmprin it decreased to 0.33 (95% CI: 0.19-0.56) for patients with both negative CCTalpha and emmprin.	nac	52-55	basigin (Ok blood group)	Homo sapiens	163-170
34896852-11	2022	Importantly, CD147-CART cells have strong anti-tumor activity against NSCLC cells in vivo in both CDX and PDX models and no adverse side effects.	Cefadroxil	98-101	basigin (Ok blood group)	Homo sapiens	13-18
34779418-7	2021	Basigin (CD147) ligands cyclophilin A and the SARS-CoV-2 spike protein triggered ROS production in T cells in vitro.	Reactive Oxygen Species	81-84	basigin (Ok blood group)	Homo sapiens	0-7
34759371-5	2021	As Tregs are produced, CD147, which is expressed on their surface, is stimulated by CD98, which is widely expressed in the physiological environment.	tregs	3-8	basigin (Ok blood group)	Homo sapiens	23-28
34759371-9	2021	More importantly, Tregs with high CD147 expression effectively inhibit inflammatory responses and maintain Foxp3 stability, which has guiding significance for the application of Tregs in immunotherapy.	tregs	18-23	basigin (Ok blood group)	Homo sapiens	34-39
34759371-9	2021	More importantly, Tregs with high CD147 expression effectively inhibit inflammatory responses and maintain Foxp3 stability, which has guiding significance for the application of Tregs in immunotherapy.	tregs	178-183	basigin (Ok blood group)	Homo sapiens	34-39
34779418-7	2021	Basigin (CD147) ligands cyclophilin A and the SARS-CoV-2 spike protein triggered ROS production in T cells in vitro.	Reactive Oxygen Species	81-84	basigin (Ok blood group)	Homo sapiens	9-14
34779418-9	2021	Dexamethasone treatment resulted in a downregulation of ROS in vitro and T cells from dexamethasone-treated patients exhibited low ROS and basigin levels.	Dexamethasone	86-99	basigin (Ok blood group)	Homo sapiens	139-146
34421346-0	2021	CD147 confers temozolomide resistance of glioma cells via the regulation of beta-TrCP/Nrf2 pathway.	Temozolomide	14-26	basigin (Ok blood group)	Homo sapiens	0-5
34625749-0	2021	The tertiary structure of the human Xkr8-Basigin complex that scrambles phospholipids at plasma membranes.	Phospholipids	72-85	basigin (Ok blood group)	Homo sapiens	41-48
34625749-7	2021	Its mutation to alanine made the Xkr8-Basigin complex constitutively active, indicating that it plays a vital role in regulating its scramblase activity.	Alanine	16-23	basigin (Ok blood group)	Homo sapiens	38-45
34625749-8	2021	The structure of Xkr8-Basigin provides insights into the molecular mechanisms underlying phospholipid scrambling.	Phospholipids	89-101	basigin (Ok blood group)	Homo sapiens	22-29
34440867-3	2021	However, it is unknown whether CD147 activity or its function in MMP regulation are affected by the diabetic environment, which is characterized by high glucose (HG) levels and an excess of glycation end products (AGEs).	Glucose	153-160	basigin (Ok blood group)	Homo sapiens	31-36
34440867-6	2021	Our findings show that carboxymethyl lysine and HG increased CD147 expression and glycosylation, which was accompanied by increases in MMP2 and MMP9 expression and activity, as well as upregulations of the N-acetylglucosaminyltransferase, MGAT5.	N(6)-carboxymethyllysine	23-43	basigin (Ok blood group)	Homo sapiens	61-66
34421346-4	2021	Herein, we demonstrate that the elevated expression of CD147 contributes to TMZ resistance in glioma cells, potentially through the post-translational regulation of Nrf2 expression.	Temozolomide	76-79	basigin (Ok blood group)	Homo sapiens	55-60
34421346-7	2021	Finally, the effect of the CD147/Nrf2 signaling on glioma progression and TMZ resistance were evaluated by functional experiments and clinical samples.	Temozolomide	74-77	basigin (Ok blood group)	Homo sapiens	27-32
34096887-5	2021	Calycosin treatment inhibited epithelial-mesenchymal transition (EMT) of breast cancer cells by significantly increasing E-cadherin levels and decreasing N-cadherin, Vimentin, CD147, MMP-2, and MMP-9 levels through downregulation of BATF and TGFbeta1.	7,3'-dihydroxy-4'-methoxyisoflavone	0-9	basigin (Ok blood group)	Homo sapiens	176-181
34421346-9	2021	Suppression of CD147 expression increased the inhibitory effect of TMZ on cell survival in both U251 and T98G cells, whereas the gain of CD147 function blocked TMZ-induced ROS production and cell death.	Temozolomide	67-70	basigin (Ok blood group)	Homo sapiens	15-20
34421346-9	2021	Suppression of CD147 expression increased the inhibitory effect of TMZ on cell survival in both U251 and T98G cells, whereas the gain of CD147 function blocked TMZ-induced ROS production and cell death.	Temozolomide	160-163	basigin (Ok blood group)	Homo sapiens	137-142
34421346-9	2021	Suppression of CD147 expression increased the inhibitory effect of TMZ on cell survival in both U251 and T98G cells, whereas the gain of CD147 function blocked TMZ-induced ROS production and cell death.	ros	172-175	basigin (Ok blood group)	Homo sapiens	137-142
34421346-12	2021	Conclusions: Our data provide the first evidence that glioma resistance to TMZ is potentially due to the activation of CD147/Nrf2 axis.	Temozolomide	75-78	basigin (Ok blood group)	Homo sapiens	119-124
34421346-13	2021	CD147 promotes Nrf2 stability through the suppression of GSK3beta/beta-TrCP dependent Nrf2 protein degradation, which results in the ablation of TMZ induced ROS production.	Temozolomide	145-148	basigin (Ok blood group)	Homo sapiens	0-5
34421346-14	2021	As such, we point out that targeting CD147/Nrf2 axis may provide a new strategy for the treatment of TMZ resistant gliomas.	Temozolomide	101-104	basigin (Ok blood group)	Homo sapiens	37-42
34258398-4	2021	Anti-CD147 and anti-CD31 antibodies could be modified with PAR28-PEG-lipo within 1 h, and each liposome was specifically taken up by CD147- and CD31-positive cells, respectively.	par28-peg-lipo	59-73	basigin (Ok blood group)	Homo sapiens	5-10
34258398-4	2021	Anti-CD147 and anti-CD31 antibodies could be modified with PAR28-PEG-lipo within 1 h, and each liposome was specifically taken up by CD147- and CD31-positive cells, respectively.	par28-peg-lipo	59-73	basigin (Ok blood group)	Homo sapiens	133-138
34258398-5	2021	The cellular amounts of doxorubicin delivered by anti-CD147 antibody-modified PAR28-PEG-lipo were significantly higher than those of isotype control antibody-modified liposomes.	Doxorubicin	24-35	basigin (Ok blood group)	Homo sapiens	54-59
34258398-5	2021	The cellular amounts of doxorubicin delivered by anti-CD147 antibody-modified PAR28-PEG-lipo were significantly higher than those of isotype control antibody-modified liposomes.	par28-peg-lipo	78-92	basigin (Ok blood group)	Homo sapiens	54-59
35298154-4	2022	The biosensor surface is first modified using Au nanoparticles (AuNPs), and then, anti-KRAS and anti-CD147, which are specific to the exosomes, are modified on the AuNPs assembled with HS-poly(ethylene glycol)-COOH (HS-PEG-COOH).	hs-poly(ethylene glycol)	185-209	basigin (Ok blood group)	Homo sapiens	101-106
35257743-10	2022	Finally, we demonstrated that interactions of MCT7 with ancillary proteins basigin/CD147 and embigin/GP70 enhanced MCT7-mediated taurine transport.	Taurine	129-136	basigin (Ok blood group)	Homo sapiens	75-82
35257743-10	2022	Finally, we demonstrated that interactions of MCT7 with ancillary proteins basigin/CD147 and embigin/GP70 enhanced MCT7-mediated taurine transport.	Taurine	129-136	basigin (Ok blood group)	Homo sapiens	83-88
6205065-5	1984	A cyclophosphamide-sensitive, I-J+, Ly-2 T transducer cell is required in the immune donor cell population for contrasuppression to be induced by the TcsF plus specific antigen.	Cyclophosphamide	2-18	basigin (Ok blood group)	Homo sapiens	150-154
35298154-4	2022	The biosensor surface is first modified using Au nanoparticles (AuNPs), and then, anti-KRAS and anti-CD147, which are specific to the exosomes, are modified on the AuNPs assembled with HS-poly(ethylene glycol)-COOH (HS-PEG-COOH).	Carbonic Acid	210-214	basigin (Ok blood group)	Homo sapiens	101-106
35298154-4	2022	The biosensor surface is first modified using Au nanoparticles (AuNPs), and then, anti-KRAS and anti-CD147, which are specific to the exosomes, are modified on the AuNPs assembled with HS-poly(ethylene glycol)-COOH (HS-PEG-COOH).	hs-peg-cooh	216-227	basigin (Ok blood group)	Homo sapiens	101-106
35215911-9	2022	We hypothesize that ferristatin II blocks the TfR1-mediated SARS-CoV-2 host cell entry; however, further studies are needed to elucidate the full mechanisms of this virus inhibition, including the effect of ferristatin II on other SARS-CoV-2 receptors, such as ACE2, Neuropilin-1 and CD147.	ferristatin II	20-34	basigin (Ok blood group)	Homo sapiens	284-289
34974521-0	2022	CD147 supports paclitaxel resistance via interacting with RanBP1.	Paclitaxel	15-25	basigin (Ok blood group)	Homo sapiens	0-5
34974521-2	2022	This study aims to verify the role and the underlying mechanisms of CD147 in paclitaxel resistance.	Paclitaxel	77-87	basigin (Ok blood group)	Homo sapiens	68-73
34974521-9	2022	In vitro and in vivo assays showed that silencing CD147 sensitized the cancer cells to paclitaxel treatment.	Paclitaxel	87-97	basigin (Ok blood group)	Homo sapiens	50-55
34974521-10	2022	CD147 protected cancer cells from paclitaxel-induced caspase-3 mediated apoptosis regardless of p53 status.	Paclitaxel	34-44	basigin (Ok blood group)	Homo sapiens	0-5
34974521-11	2022	Truncation analysis showed that the intracellular domain of CD147 (CD147ICD) was indispensable for CD147-regulated sensitivity to paclitaxel.	Paclitaxel	130-140	basigin (Ok blood group)	Homo sapiens	60-65
34974521-11	2022	Truncation analysis showed that the intracellular domain of CD147 (CD147ICD) was indispensable for CD147-regulated sensitivity to paclitaxel.	Paclitaxel	130-140	basigin (Ok blood group)	Homo sapiens	67-75
34974521-11	2022	Truncation analysis showed that the intracellular domain of CD147 (CD147ICD) was indispensable for CD147-regulated sensitivity to paclitaxel.	Paclitaxel	130-140	basigin (Ok blood group)	Homo sapiens	99-104
34974521-13	2022	Furthermore, we showed that RanBP1 mediated CD147-regulated microtubule stability and dynamics as well as response to paclitaxel treatment.	Paclitaxel	118-128	basigin (Ok blood group)	Homo sapiens	44-49
34974521-14	2022	These results demonstrated that CD147 regulated paclitaxel response by interacting with the C-terminal tail of RanBP1 and targeting CD147 may be a promising strategy for preventing paclitaxel resistant.	Paclitaxel	48-58	basigin (Ok blood group)	Homo sapiens	32-37
34974521-14	2022	These results demonstrated that CD147 regulated paclitaxel response by interacting with the C-terminal tail of RanBP1 and targeting CD147 may be a promising strategy for preventing paclitaxel resistant.	Paclitaxel	48-58	basigin (Ok blood group)	Homo sapiens	132-137
34974521-14	2022	These results demonstrated that CD147 regulated paclitaxel response by interacting with the C-terminal tail of RanBP1 and targeting CD147 may be a promising strategy for preventing paclitaxel resistant.	Paclitaxel	181-191	basigin (Ok blood group)	Homo sapiens	32-37
34974521-14	2022	These results demonstrated that CD147 regulated paclitaxel response by interacting with the C-terminal tail of RanBP1 and targeting CD147 may be a promising strategy for preventing paclitaxel resistant.	Paclitaxel	181-191	basigin (Ok blood group)	Homo sapiens	132-137
34619707-4	2022	To investigate the metabolic phenotype of malignant lymphoma associated with lactate transport, we analyzed immunohistochemical expressions of MCT1, MCT4, and CD147 in 247 cases of various malignant lymphomas.	Lactic Acid	77-84	basigin (Ok blood group)	Homo sapiens	159-164
35054026-1	2022	Basigin (BSG, CD147) is a multifunctional protein involved in cancer cell survival, mostly by controlling lactate transport through its interaction with monocarboxylate transporters (MCTs) such as MCT1.	Lactic Acid	106-113	basigin (Ok blood group)	Homo sapiens	0-7
35054026-1	2022	Basigin (BSG, CD147) is a multifunctional protein involved in cancer cell survival, mostly by controlling lactate transport through its interaction with monocarboxylate transporters (MCTs) such as MCT1.	Lactic Acid	106-113	basigin (Ok blood group)	Homo sapiens	9-12
35054026-1	2022	Basigin (BSG, CD147) is a multifunctional protein involved in cancer cell survival, mostly by controlling lactate transport through its interaction with monocarboxylate transporters (MCTs) such as MCT1.	Lactic Acid	106-113	basigin (Ok blood group)	Homo sapiens	14-19
33967078-5	2021	RESULTS: HIF-1alpha, CD147, and GLUT1 were highly expressed and the glycolytic capacity was increased in lesions of psoriasis vulgaris; HIF-1alpha upregulated the expression of CD147 and GLUT1, increased the lactate production and decreased the ATP level in CoCl2-treated HaCaT cells, while CD147 and GLUT1 directly or indirectly bound to each other.	Lactic Acid	208-215	basigin (Ok blood group)	Homo sapiens	21-26
33967078-5	2021	RESULTS: HIF-1alpha, CD147, and GLUT1 were highly expressed and the glycolytic capacity was increased in lesions of psoriasis vulgaris; HIF-1alpha upregulated the expression of CD147 and GLUT1, increased the lactate production and decreased the ATP level in CoCl2-treated HaCaT cells, while CD147 and GLUT1 directly or indirectly bound to each other.	Lactic Acid	208-215	basigin (Ok blood group)	Homo sapiens	177-182
33999492-8	2021	The inhibitory effect of pCMBS was proposed to be indirect via modification of the chaperone basigin.	4-Chloromercuribenzenesulfonate	25-30	basigin (Ok blood group)	Homo sapiens	93-100
33967078-5	2021	RESULTS: HIF-1alpha, CD147, and GLUT1 were highly expressed and the glycolytic capacity was increased in lesions of psoriasis vulgaris; HIF-1alpha upregulated the expression of CD147 and GLUT1, increased the lactate production and decreased the ATP level in CoCl2-treated HaCaT cells, while CD147 and GLUT1 directly or indirectly bound to each other.	Adenosine Triphosphate	245-248	basigin (Ok blood group)	Homo sapiens	21-26
33967078-5	2021	RESULTS: HIF-1alpha, CD147, and GLUT1 were highly expressed and the glycolytic capacity was increased in lesions of psoriasis vulgaris; HIF-1alpha upregulated the expression of CD147 and GLUT1, increased the lactate production and decreased the ATP level in CoCl2-treated HaCaT cells, while CD147 and GLUT1 directly or indirectly bound to each other.	Lactic Acid	208-215	basigin (Ok blood group)	Homo sapiens	177-182
33967078-5	2021	RESULTS: HIF-1alpha, CD147, and GLUT1 were highly expressed and the glycolytic capacity was increased in lesions of psoriasis vulgaris; HIF-1alpha upregulated the expression of CD147 and GLUT1, increased the lactate production and decreased the ATP level in CoCl2-treated HaCaT cells, while CD147 and GLUT1 directly or indirectly bound to each other.	Adenosine Triphosphate	245-248	basigin (Ok blood group)	Homo sapiens	177-182
33967078-5	2021	RESULTS: HIF-1alpha, CD147, and GLUT1 were highly expressed and the glycolytic capacity was increased in lesions of psoriasis vulgaris; HIF-1alpha upregulated the expression of CD147 and GLUT1, increased the lactate production and decreased the ATP level in CoCl2-treated HaCaT cells, while CD147 and GLUT1 directly or indirectly bound to each other.	Adenosine Triphosphate	245-248	basigin (Ok blood group)	Homo sapiens	177-182
33967078-5	2021	RESULTS: HIF-1alpha, CD147, and GLUT1 were highly expressed and the glycolytic capacity was increased in lesions of psoriasis vulgaris; HIF-1alpha upregulated the expression of CD147 and GLUT1, increased the lactate production and decreased the ATP level in CoCl2-treated HaCaT cells, while CD147 and GLUT1 directly or indirectly bound to each other.	cobaltous chloride	258-263	basigin (Ok blood group)	Homo sapiens	21-26
33967078-5	2021	RESULTS: HIF-1alpha, CD147, and GLUT1 were highly expressed and the glycolytic capacity was increased in lesions of psoriasis vulgaris; HIF-1alpha upregulated the expression of CD147 and GLUT1, increased the lactate production and decreased the ATP level in CoCl2-treated HaCaT cells, while CD147 and GLUT1 directly or indirectly bound to each other.	cobaltous chloride	258-263	basigin (Ok blood group)	Homo sapiens	177-182
33967078-5	2021	RESULTS: HIF-1alpha, CD147, and GLUT1 were highly expressed and the glycolytic capacity was increased in lesions of psoriasis vulgaris; HIF-1alpha upregulated the expression of CD147 and GLUT1, increased the lactate production and decreased the ATP level in CoCl2-treated HaCaT cells, while CD147 and GLUT1 directly or indirectly bound to each other.	cobaltous chloride	258-263	basigin (Ok blood group)	Homo sapiens	177-182
33959010-0	2021	Berberine Regulated miR150-5p to Inhibit P2X7 Receptor, EMMPRIN and MMP-9 Expression in oxLDL Induced Macrophages.	Berberine	0-9	basigin (Ok blood group)	Homo sapiens	56-63
33959010-2	2021	Our previous report showed that berberine regulates the expression of both EMMPRIN and MMP-9.	Berberine	32-41	basigin (Ok blood group)	Homo sapiens	75-82
33959010-7	2021	And A-438079 (a P2X7R inhibitor) or miR150-5p mimic treatment greatly reversed the upregulation of EMMPRIN and MMP-9 expression.	3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine	4-12	basigin (Ok blood group)	Homo sapiens	99-106
33959010-8	2021	Moreover, A-438079 significantly reduced oxLDL-induced AMP-activated protein kinase-alpha (AMPK-alpha) phosphorylation and reversed the activation of mitogen-activated protein kinase (MAPK), which in turn decreased the expression of EMMPRIN and MMP-9.	3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine	10-18	basigin (Ok blood group)	Homo sapiens	233-240
33959010-10	2021	Accordingly, exposure to berberine markedly upregulated miR150-5p, decreased P2X7R expression and downregulated MMP-9 and EMMPRIN levels in oxLDL-induced macrophages, resulting in AMPK-alpha/MAPK (JNK, p38, and ERK) inactivation.	Berberine	25-34	basigin (Ok blood group)	Homo sapiens	122-129
33959010-11	2021	Overall, these results indicate that berberine increased miR150-5p level, subsequently inhibits P2X7R-mediated EMMPRIN and MMP-9 expression by suppressing AMPK-alpha and MAPK signaling in oxLDL-induced macrophages.	Berberine	37-46	basigin (Ok blood group)	Homo sapiens	111-118
33927478-7	2021	Furthermore, CD147 silencing decreased the glucose uptake, lactate production in HSCs, and repressed the lactate dehydrogenase (LDH) activity, the expression of hexokinase 2 (HK2), glucose transporter 1 (Glut1).	Glucose	43-50	basigin (Ok blood group)	Homo sapiens	13-18
33927478-7	2021	Furthermore, CD147 silencing decreased the glucose uptake, lactate production in HSCs, and repressed the lactate dehydrogenase (LDH) activity, the expression of hexokinase 2 (HK2), glucose transporter 1 (Glut1).	Lactic Acid	59-66	basigin (Ok blood group)	Homo sapiens	13-18
33649734-6	2021	This study selected these drugs for MD simulation investigation whose results demonstrated that ledipasvir with ACE2, estradiol benzoate with CD147, and vancomycin with RDRP represented the most favorable DeltaG.	estradiol 3-benzoate	118-136	basigin (Ok blood group)	Homo sapiens	142-147
33654226-8	2022	Mechanistically, LOC554202 competitively bound to miR-485-5p and prevented the suppressive effects of miR-485-5p on its target gene basigin (BSG), which finally led to HCC metastasis, EMT, and docetaxel chemoresistance.	loc554202	17-26	basigin (Ok blood group)	Homo sapiens	132-139
33654226-8	2022	Mechanistically, LOC554202 competitively bound to miR-485-5p and prevented the suppressive effects of miR-485-5p on its target gene basigin (BSG), which finally led to HCC metastasis, EMT, and docetaxel chemoresistance.	loc554202	17-26	basigin (Ok blood group)	Homo sapiens	141-144
33654226-8	2022	Mechanistically, LOC554202 competitively bound to miR-485-5p and prevented the suppressive effects of miR-485-5p on its target gene basigin (BSG), which finally led to HCC metastasis, EMT, and docetaxel chemoresistance.	Docetaxel	193-202	basigin (Ok blood group)	Homo sapiens	141-144
33009925-0	2021	Resveratrol-induced apoptosis is associated with regulating the miR-492/CD147 pathway in malignant melanoma cells.	Resveratrol	0-11	basigin (Ok blood group)	Homo sapiens	72-77
33406400-0	2021	Di-methylation of CD147-K234 Promotes the Progression of NSCLC by Enhancing Lactate Export.	Lactic Acid	76-83	basigin (Ok blood group)	Homo sapiens	18-23
33406400-6	2021	Overexpression of CD147-K234me2 and KMT5A enhances glycolysis and lactate export in NSCLC cells.	Lactic Acid	66-73	basigin (Ok blood group)	Homo sapiens	18-23
33193313-6	2020	Further functional studies showed that anti-CD147 mAb decreased the activation of AKT, mTORC1 and STAT3 signaling, which is known to enhance Th17 responses.	th17	141-145	basigin (Ok blood group)	Homo sapiens	44-49
33197849-4	2020	In this article, we report the discovery of the first CD147 protein proteolysis targeting chimeras (PROTACs) derived from the natural product pseudolaric acid B (PAB).	pseudolaric acid B	142-160	basigin (Ok blood group)	Homo sapiens	54-59
33197849-4	2020	In this article, we report the discovery of the first CD147 protein proteolysis targeting chimeras (PROTACs) derived from the natural product pseudolaric acid B (PAB).	pseudolaric acid B	162-165	basigin (Ok blood group)	Homo sapiens	54-59
33232272-4	2020	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily interacts with the cell surface receptor angiotensin-converting enzyme (ACE) 2 and other accessory proteins such as 78 kDa glucose-regulated protein 78 (GRP78) and CD147.	Glucose	194-201	basigin (Ok blood group)	Homo sapiens	235-240
33254482-4	2020	S1 is subdivided in domains S1A (or NTD) and S1B (or RBD), with experimental and in silico studies suggesting that the former binds to sialic acid-containing glycoproteins, such as CD147, whereas the latter binds to ACE2 receptor.	N-Acetylneuraminic Acid	135-146	basigin (Ok blood group)	Homo sapiens	181-186
32448731-4	2021	METHODS: Maleimidoethyl 3-(guanidinomethyl)-5-iodobenzoate ([131I]MEGMB) and its N-succinimidyl ester analogue, iso-[125I]SGMIB, were labeled by halodestannylation and conjugated with 5F7GGC and 5F7, respectively.	maleimidoethyl 3-(guanidinomethyl)-5-iodobenzoate	9-58	basigin (Ok blood group)	Homo sapiens	184-187
32448731-4	2021	METHODS: Maleimidoethyl 3-(guanidinomethyl)-5-iodobenzoate ([131I]MEGMB) and its N-succinimidyl ester analogue, iso-[125I]SGMIB, were labeled by halodestannylation and conjugated with 5F7GGC and 5F7, respectively.	iso-[125i]sgmib	112-127	basigin (Ok blood group)	Homo sapiens	184-187
32448731-11	2021	CONCLUSION: [131I]MEGMIB-5F7GGC offers similar tumor targeting as iso-[125I]SGMIB-5F7 but with generally lower normal tissue uptake.	megmib	18-24	basigin (Ok blood group)	Homo sapiens	25-28
33374805-0	2020	Discovery and Biological Evaluation of CD147 N-Glycan Inhibitors: A New Direction in the Treatment of Tumor Metastasis.	n-glycan	45-53	basigin (Ok blood group)	Homo sapiens	39-44
33374805-1	2020	N-glycosylation is instrumental to the regulation of CD147 functions, including the maturation of CD147, secretion of matrix metalloproteinases (MMPs), and promotion of tumor metastasis.	Nitrogen	0-1	basigin (Ok blood group)	Homo sapiens	53-58
33374805-1	2020	N-glycosylation is instrumental to the regulation of CD147 functions, including the maturation of CD147, secretion of matrix metalloproteinases (MMPs), and promotion of tumor metastasis.	Nitrogen	0-1	basigin (Ok blood group)	Homo sapiens	98-103
33374805-9	2020	Finally, the structures of the other potential CD147 N-glycosylation inhibitors may eventually provide guidance for future optimization.	Nitrogen	53-54	basigin (Ok blood group)	Homo sapiens	47-52
32419574-6	2020	Global inhibition of alpha1,2-mannosidase I activity with deoxymannojirimycin markedly attenuates the glycosylation of CD147 and disrupts its surface distribution at the leading edge, concomitantly reducing the expression of matrix metalloproteinase-9.	1-Deoxynojirimycin	58-77	basigin (Ok blood group)	Homo sapiens	119-124
32419574-7	2020	Likewise, treatment with deoxymannojirimycin or siRNA-mediated knockdown of MAN1C1 impairs the ability of the carbohydrate-binding protein galectin-3 to stimulate CD147 clustering in unwounded cells.	1-Deoxynojirimycin	25-44	basigin (Ok blood group)	Homo sapiens	163-168
32419574-7	2020	Likewise, treatment with deoxymannojirimycin or siRNA-mediated knockdown of MAN1C1 impairs the ability of the carbohydrate-binding protein galectin-3 to stimulate CD147 clustering in unwounded cells.	Carbohydrates	110-122	basigin (Ok blood group)	Homo sapiens	163-168
32419574-8	2020	We conclude that the mannose-trimming activity of alpha1,2-mannosidase I coordinates the clustering and compartmentalization of CD147 that follows an epithelial injury.	Mannose	21-28	basigin (Ok blood group)	Homo sapiens	128-133
33193313-8	2020	In collagen-induced arthritis model, anti-CD147 mAb treatment reduced the Th17 levels and severity of arthritis in vivo.	th17	74-78	basigin (Ok blood group)	Homo sapiens	42-47
32855684-9	2020	Treatment with lithium chloride (LiCl), a Wnt/beta-catenin pathway agonist or a GSK-3beta inhibitor, attenuated CD147 downregulation-induced p-beta-catenin (Ser33/37/Thr41) expression, which resulted in the upregulation of beta-catenin in the nucleus.	Lithium Chloride	15-31	basigin (Ok blood group)	Homo sapiens	112-117
33132099-5	2021	RESULTS: Administration of 0.3 mg/kg ivabradine significantly reduced cardiogenic shock-induced ventricular necrosis and expression of MMP-9 without affecting EMMPRIN mRNA, protein, or protein glycosylation (required for MMP activation).	Ivabradine	37-47	basigin (Ok blood group)	Homo sapiens	159-166
33132099-6	2021	However, ivabradine increased the levels of the caveolin-3/LG-EMMPRIN (low-glycosylated EMMPRIN) and caveolin-3/HCN4 protein complexes and decreased that of a new complex between HCN4 and high-glycosylated EMMPRIN formed in response to cardiogenic shock.	Ivabradine	9-19	basigin (Ok blood group)	Homo sapiens	62-69
33132099-6	2021	However, ivabradine increased the levels of the caveolin-3/LG-EMMPRIN (low-glycosylated EMMPRIN) and caveolin-3/HCN4 protein complexes and decreased that of a new complex between HCN4 and high-glycosylated EMMPRIN formed in response to cardiogenic shock.	Ivabradine	9-19	basigin (Ok blood group)	Homo sapiens	88-95
33132099-9	2021	CONCLUSIONS: In addition to inhibition of the I(f) current, ivabradine may induce cardiac protection by inhibiting ECM degradation through preservation of the caveolin-3/LG-EMMPRIN complex and control heart rate by stabilizing the caveolin-3/HCN4 complex.	Ivabradine	60-70	basigin (Ok blood group)	Homo sapiens	173-180
33178600-8	2020	We demonstrated that knockdown of CD147 inhibited glioma invasiveness and metastasis with norepinephrine stimulation.	Norepinephrine	90-104	basigin (Ok blood group)	Homo sapiens	34-39
33178600-9	2020	Luciferase reporter gene experiments further demonstrated that the expression of CD147 is up-regulated primarily by norepinephrine via the beta-Adrenalin receptor (betaAR)-beta-arrestin1-ERK1/2-Sp1 pathway.	Norepinephrine	116-130	basigin (Ok blood group)	Homo sapiens	81-86
33178600-10	2020	High expression of CD147 promoted the secretion of MMP-2 and the increment of lactic acid, which accelerated the augmented invasion and metastasis of glioma induced by psychological stress.	Lactic Acid	78-89	basigin (Ok blood group)	Homo sapiens	19-24
32855684-8	2020	Importantly, the downregulation of CD147 in LNCaP cells inhibited the expression levels of nuclear beta-catenin and Snail, and phosphorylation of glycogen synthase kinase (GSK)-3beta on Ser 9, and increased the expression of phosphorylated (p)-beta-catenin (Ser33/37/Thr41).	Serine	186-189	basigin (Ok blood group)	Homo sapiens	35-40
32855684-9	2020	Treatment with lithium chloride (LiCl), a Wnt/beta-catenin pathway agonist or a GSK-3beta inhibitor, attenuated CD147 downregulation-induced p-beta-catenin (Ser33/37/Thr41) expression, which resulted in the upregulation of beta-catenin in the nucleus.	Lithium Chloride	33-37	basigin (Ok blood group)	Homo sapiens	112-117
32673940-7	2020	Apart from the anti-monoclonal antibody, it is recommended to explore the use of grape seed and skin containing mouthwash as an adjunct, which could also have anti EMMPRIN effects in patients with OSCC and OPMDs.	grape seed	81-91	basigin (Ok blood group)	Homo sapiens	164-171
32887638-3	2020	Lactate transport into and out of cells, crucial to maintaining intracellular pH homeostasis and glycolysis, is carried out by monocarboxylate transporters (MCTs) and the chaperone basigin (CD147).	Lactic Acid	0-7	basigin (Ok blood group)	Homo sapiens	181-188
33013867-7	2020	The findings of this study verified that rMgPa could induce the secretion of eCypA in SV-HUC-1 cells and thus promote the protein and mRNA expression of IL-1beta, IL-6, TNF-alpha and MMP-9 via CypA-CD147 interaction and thus activating ERK-NF-kappaB pathway, which is beneficial to elucidate the pathogenesis and possible pathogenic mechanism of M. genitalium to host cells.	rmgpa	41-46	basigin (Ok blood group)	Homo sapiens	198-203
32887638-3	2020	Lactate transport into and out of cells, crucial to maintaining intracellular pH homeostasis and glycolysis, is carried out by monocarboxylate transporters (MCTs) and the chaperone basigin (CD147).	Lactic Acid	0-7	basigin (Ok blood group)	Homo sapiens	190-195
32884039-7	2020	Nevertheless, studies of basigin mAb properties" effect on RMT are limited.	RMT	59-62	basigin (Ok blood group)	Homo sapiens	25-32
32703414-9	2020	Furthermore, butyrate treatment of HT-29 cells significantly decreased both MCT1 protein abundance (P < 0.001, N = 4, unpaired T-test) and glycosylation of its" chaperone protein, CD147 (P < 0.001, N = 4, unpaired T-test).	Butyrates	13-21	basigin (Ok blood group)	Homo sapiens	180-185
33053534-5	2020	Western blotting was used to analyze the expression of CD147 and Slug in HaCaT cells in the high-glucose environment.	Glucose	97-104	basigin (Ok blood group)	Homo sapiens	55-60
33053534-11	2020	CD147 and Slug expressions were down-regulated in HaCaT cells cultured with high glucose (all P<0.05).	Glucose	81-88	basigin (Ok blood group)	Homo sapiens	0-5
32754264-16	2020	Notably, the HSPA12A overexpression-induced inhibition of lactate export and migration were abolished by CD147 overexpression.	Lactic Acid	58-65	basigin (Ok blood group)	Homo sapiens	105-110
32456796-0	2020	CD147 promotes DNA damage response and gemcitabine resistance via targeting ATM/ATR/p53 and affects prognosis in pancreatic cancer.	gemcitabine	39-50	basigin (Ok blood group)	Homo sapiens	0-5
32456796-5	2020	CD147 knockdown or monoclonal antibodies improved the killing effects of gemcitabine in gemcitabine resistant cells, exhibiting reduced activation of ATM/p53.	gemcitabine	73-84	basigin (Ok blood group)	Homo sapiens	0-5
32456796-5	2020	CD147 knockdown or monoclonal antibodies improved the killing effects of gemcitabine in gemcitabine resistant cells, exhibiting reduced activation of ATM/p53.	gemcitabine	88-99	basigin (Ok blood group)	Homo sapiens	0-5
32456796-6	2020	Moreover, we found the interaction of CD147 with ATM, ATR and p53, which was augmented in gemcitabine resistant cells.	gemcitabine	90-101	basigin (Ok blood group)	Homo sapiens	38-43
32456796-8	2020	Our studies thus identify CD147 as a critical player in DDR programing that affects gemcitabine therapeutic outcomes of pancreatic cancer patients.	gemcitabine	84-95	basigin (Ok blood group)	Homo sapiens	26-31
32714980-8	2020	Mechanically, CD147 promoted phosphorylation of NF-kappaB p65 in IECs, while inhibition of NF-kappaB activity by the NF-kappaB inhibitor BAY11-7082 reversed the effect of CD147 on IL-1beta and IL-18 secretion.	3-(4-methylphenylsulfonyl)-2-propenenitrile	137-147	basigin (Ok blood group)	Homo sapiens	171-176
32589459-1	2020	PURPOSE: The spike proteins of SARS-CoV-2 interact with ACE2 or basigin/CD147 receptors, regulating human-to-human transmissions of COVID-19 together with serine protease TMPRSS2.	Serine	155-161	basigin (Ok blood group)	Homo sapiens	72-77
32307653-0	2020	CD147 as a Target for COVID-19 Treatment: Suggested Effects of Azithromycin and Stem Cell Engagement.	Azithromycin	63-75	basigin (Ok blood group)	Homo sapiens	0-5
31090215-6	2020	CD147 stimulates hyaluronan synthesis and interaction of hyaluronan with its receptors, in particular CD44 and LYVE-1, which in turn result in activation of multiprotein complexes containing members of the membrane-type matrix metalloproteinase, receptor tyrosine kinase, ABC drug transporter, or MCT families within lipid raft domains.	Hyaluronic Acid	17-27	basigin (Ok blood group)	Homo sapiens	0-5
32164877-2	2020	Radioactive iodine (131I)-labelled metuximab is a radiolabelled monoclonal antibody against the CD147 (also known as basigin or HAb18G) antigen that is expressed in HCC.	radioactive iodine	0-18	basigin (Ok blood group)	Homo sapiens	96-101
32164877-2	2020	Radioactive iodine (131I)-labelled metuximab is a radiolabelled monoclonal antibody against the CD147 (also known as basigin or HAb18G) antigen that is expressed in HCC.	radioactive iodine	0-18	basigin (Ok blood group)	Homo sapiens	117-124
32626520-11	2020	There was a positive correlation between LCA-binding glycans and CD147 expression in clinical samples.	Polysaccharides	53-60	basigin (Ok blood group)	Homo sapiens	65-70
32307653-4	2020	Studies suggest beneficial effects of azithromycin in reducing viral load of hospitalized patients, possibly interfering with ligand/CD147 receptor interactions; however, its possible effects on SARS-CoV-2 invasion has not yet been evaluated.	Azithromycin	38-50	basigin (Ok blood group)	Homo sapiens	133-138
32307653-5	2020	In addition to the possible effect in invasion, azithromycin decreases the expression of some metalloproteinases (downstream to CD147), induces anti-viral responses in primary human bronchial epithelial infected with rhinovirus, decreasing viral replication and release.	Azithromycin	48-60	basigin (Ok blood group)	Homo sapiens	128-133
32149134-2	2020	Mature CD147 is an N-linked glycosylated protein and exists on the transmembrane and as soluble forms in tumors.	Nitrogen	19-20	basigin (Ok blood group)	Homo sapiens	7-12
32291412-10	2020	Finally, through virtual screening, we identified amodiaquine as a potential inhibitor targeting the Fyn/CD147 axis.	Amodiaquine	50-61	basigin (Ok blood group)	Homo sapiens	105-110
32291412-11	2020	Amodiaquine treatment dramatically inhibited the phosphorylation of CD147 by Fyn, thus attenuating melanoma cell growth and invasion in vitro and in vivo, suggesting that amodiaquine is a promising inhibitor for melanoma treatment.	Amodiaquine	0-11	basigin (Ok blood group)	Homo sapiens	68-73
32291412-11	2020	Amodiaquine treatment dramatically inhibited the phosphorylation of CD147 by Fyn, thus attenuating melanoma cell growth and invasion in vitro and in vivo, suggesting that amodiaquine is a promising inhibitor for melanoma treatment.	Amodiaquine	171-182	basigin (Ok blood group)	Homo sapiens	68-73
32349289-6	2020	Sinomenine decreases the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9, and the extracellular inducer of matrix metalloproteinase (EMMPRIN/CD147), but elevates the expression of reversion-inducing cysteine-rich proteins with kazal motifs (RECK) and the tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2.	sinomenine	0-10	basigin (Ok blood group)	Homo sapiens	141-148
32349289-6	2020	Sinomenine decreases the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9, and the extracellular inducer of matrix metalloproteinase (EMMPRIN/CD147), but elevates the expression of reversion-inducing cysteine-rich proteins with kazal motifs (RECK) and the tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2.	sinomenine	0-10	basigin (Ok blood group)	Homo sapiens	149-154
32317318-8	2020	Moreover, in human monocytes, anti-CD147 partially abrogated EtpE-C-induced blockade of ROS generation.	Reactive Oxygen Species	88-91	basigin (Ok blood group)	Homo sapiens	35-40
32232009-8	2020	The correlated alterations in glycosyltransferase expression and tissue glycomics were then evaluated by differential glycan profiling of a membrane N-glycoprotein, basigin, expressed in tumor and non-tumor pancreatic cells.	Polysaccharides	118-124	basigin (Ok blood group)	Homo sapiens	165-172
32232009-9	2020	The focused differential glycomic profiling for endogenous basigin derived from non-tumor and cancerous regions of PDAC tissue sections demonstrated that PDAC-relevant glycan alterations of basigin closely reflected the notable features in the disease-specific alterations in the tissue glycomes.	Polysaccharides	168-174	basigin (Ok blood group)	Homo sapiens	59-66
32232009-9	2020	The focused differential glycomic profiling for endogenous basigin derived from non-tumor and cancerous regions of PDAC tissue sections demonstrated that PDAC-relevant glycan alterations of basigin closely reflected the notable features in the disease-specific alterations in the tissue glycomes.	Polysaccharides	168-174	basigin (Ok blood group)	Homo sapiens	190-197
32093254-7	2020	Differentiation to HCO indicated an increased gene expression of CDX2, CD147, and CA2, and increased basal transepithelial electrical resistance compared to HIO.	hco	19-22	basigin (Ok blood group)	Homo sapiens	71-76
31964828-5	2020	We found that meningococcal Tfp specifically recognize a triantennary sialylated poly-N-acetyllactosamine-containing N-glycan exposed on the human receptor CD147/Basigin, while fucosylated derivatives of this N-glycan impaired bacterial adhesion.	poly-N-acetyllactosamine	81-105	basigin (Ok blood group)	Homo sapiens	156-161
31964828-5	2020	We found that meningococcal Tfp specifically recognize a triantennary sialylated poly-N-acetyllactosamine-containing N-glycan exposed on the human receptor CD147/Basigin, while fucosylated derivatives of this N-glycan impaired bacterial adhesion.	poly-N-acetyllactosamine	81-105	basigin (Ok blood group)	Homo sapiens	162-169
31933828-4	2019	Moreover, we have confirmed that knockdown of CD147 led to reduced levels of cellular lipid content in shCD147 cells by BODIPY staining.	4,4-difluoro-4-bora-3a,4a-diaza-s-indacene	120-126	basigin (Ok blood group)	Homo sapiens	46-51
31862132-0	2020	Corrigendum to "Triptolide inhibits the migration and invasion of human prostate cancer cells via Caveolin-1/CD147/MMPs pathway" [Biomed.	triptolide	16-26	basigin (Ok blood group)	Homo sapiens	109-114
31325330-5	2020	The resulting seven-mutation design exhibited 1900-fold higher affinity (KD approximately 1 nM) for RH5 with a very slow binding off rate (0.23 h-1 ) and reduced the effective Plasmodium growth-inhibitory concentration by at least 10-fold compared to human basigin.	4-[(3~{R})-1-oxidanyl-3,4-dihydro-2,1-benzoxaborinin-3-yl]-2-(pyridin-3-ylmethoxy)benzenecarboximidamide	100-103	basigin (Ok blood group)	Homo sapiens	257-264
31933828-0	2019	CD147 promotes cervical cancer migration and invasion by up-regulating fatty acid synthase expression.	Fatty Acids	71-81	basigin (Ok blood group)	Homo sapiens	0-5
32321312-3	2020	In the co-culture, we found that CsA inhibited the expression of cyclophilin A (CyPA), CD147 and the activities of MMPs, which were all induced by P.g-LPS.	Cyclosporine	33-36	basigin (Ok blood group)	Homo sapiens	87-92
32321312-3	2020	In the co-culture, we found that CsA inhibited the expression of cyclophilin A (CyPA), CD147 and the activities of MMPs, which were all induced by P.g-LPS.	p.g-lps	147-154	basigin (Ok blood group)	Homo sapiens	87-92
32321312-4	2020	We also found that P.g-LPS and recombinant human CyPA increased activation of ERK1/2 and IkappaB (an NF-kappaB inhibitory protein), but CsA and the anti-CD147 antibody significantly inhibited these effects.	p.g-lps	19-26	basigin (Ok blood group)	Homo sapiens	153-158
32321312-5	2020	Taken together, CsA in the presence of P.g-LPS might suppress MMP activities by blocking the CyPA/CD147 interaction that results in the inhibition of ERK1/2 and NF-kappaB signaling by interfering with the phosphorylation of ERK1/2 and IkappaB.	Cyclosporine	16-19	basigin (Ok blood group)	Homo sapiens	98-103
31723238-5	2020	Application of an antibody, directed against the CD147-Ig1 domain, displaces CAIX from the transporter and suppresses CAIX-mediated facilitation of proton-coupled lactate transport.	Lactic Acid	163-170	basigin (Ok blood group)	Homo sapiens	49-54
31401349-9	2019	Finally, we found that interference of CD147 expression blocked the dihydrotestosterone (DHT)-induced reduction in Abeta and the protection of cells.	Dihydrotestosterone	68-87	basigin (Ok blood group)	Homo sapiens	39-44
31401349-9	2019	Finally, we found that interference of CD147 expression blocked the dihydrotestosterone (DHT)-induced reduction in Abeta and the protection of cells.	Dihydrotestosterone	89-92	basigin (Ok blood group)	Homo sapiens	39-44
31401349-10	2019	DHT regulates MMP-2"s expression through CD147.	Dihydrotestosterone	0-3	basigin (Ok blood group)	Homo sapiens	41-46