PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 31903140-4 2020 Results: Global histone methylation analysis revealed a pronounced increase of the repressive histone trimethylation in three different cell types with mdig depletion, including trimethylation of lysines 9 and 27 on histone H3 (H3K9me3, H3K27me3) and trimethylation of lysine 20 of histone H4 (H4K20me3). K.H.3 224-226 ribosomal oxygenase 2 Homo sapiens 152-156 2891811-3 1987 ROX exhibited much weaker inhibitory effects on each enzyme activity with 12 to 100-fold higher values of Ki than those of CIM. Cimetidine 123-126 ribosomal oxygenase 2 Homo sapiens 0-3 2891811-4 1987 CIM gave type II difference spectra with dissociation constants (Ks) of 10.4 and 111 microM while ROX gave reverse type I difference spectra with Ks of 55.6 microM. Potassium 146-148 ribosomal oxygenase 2 Homo sapiens 98-101 33760153-13 2021 In conclusion, mdig is an oxygen-sensitive protein that promotes tumor growth and angiogenesis by activating the EGFR/p-EGFR/VEGF-A/VEGF-R1/R2 pathway and inhibits lymphangiogenesis by blocking the HIF-1alpha/VEGF-C/D/VEGF-R3 pathway. Oxygen 26-32 ribosomal oxygenase 2 Homo sapiens 15-19 31903140-4 2020 Results: Global histone methylation analysis revealed a pronounced increase of the repressive histone trimethylation in three different cell types with mdig depletion, including trimethylation of lysines 9 and 27 on histone H3 (H3K9me3, H3K27me3) and trimethylation of lysine 20 of histone H4 (H4K20me3). H-2K(K) antigen 290-292 ribosomal oxygenase 2 Homo sapiens 152-156 31903140-4 2020 Results: Global histone methylation analysis revealed a pronounced increase of the repressive histone trimethylation in three different cell types with mdig depletion, including trimethylation of lysines 9 and 27 on histone H3 (H3K9me3, H3K27me3) and trimethylation of lysine 20 of histone H4 (H4K20me3). H-2K(K) antigen 294-302 ribosomal oxygenase 2 Homo sapiens 152-156 30546450-5 2018 The effect of mdig on the proliferation of NCI-H1650 cells was observed through 3-(4,5)-dimethylthiazol (-z-y1)-3,5-di-phenyl tetrazolium bromide (MTT) assay, and flow cytometry was used to detect the impact of mdig on cell cycle and apoptosis of NCI-H1650 cells. monooxyethylene trimethylolpropane tristearate 147-150 ribosomal oxygenase 2 Homo sapiens 14-18 31579066-0 2019 MDIG promotes cisplatin resistance of lung adenocarcinoma by regulating ABC transporter expression via activation of the WNT/beta-catenin signaling pathway. Cisplatin 14-23 ribosomal oxygenase 2 Homo sapiens 0-4 31579066-2 2019 The aim of the present study was to determine whether MDIG is involved in cisplatin (DDP) resistance in lung adenocarcinoma, and to investigate the associated molecular mechanism. Cisplatin 74-83 ribosomal oxygenase 2 Homo sapiens 54-58 31579066-2 2019 The aim of the present study was to determine whether MDIG is involved in cisplatin (DDP) resistance in lung adenocarcinoma, and to investigate the associated molecular mechanism. 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate 85-88 ribosomal oxygenase 2 Homo sapiens 54-58 31579066-4 2019 The results revealed that the mRNA and protein expression levels of MDIG in A549/DDP cells were significantly higher compared with those in A549 cells, and that the protein expression levels of MDIG increased in a dose-dependent manner with increasing DDP concentrations. 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate 81-84 ribosomal oxygenase 2 Homo sapiens 68-72 31579066-4 2019 The results revealed that the mRNA and protein expression levels of MDIG in A549/DDP cells were significantly higher compared with those in A549 cells, and that the protein expression levels of MDIG increased in a dose-dependent manner with increasing DDP concentrations. 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate 81-84 ribosomal oxygenase 2 Homo sapiens 194-198 31579066-4 2019 The results revealed that the mRNA and protein expression levels of MDIG in A549/DDP cells were significantly higher compared with those in A549 cells, and that the protein expression levels of MDIG increased in a dose-dependent manner with increasing DDP concentrations. 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate 252-255 ribosomal oxygenase 2 Homo sapiens 68-72 31579066-4 2019 The results revealed that the mRNA and protein expression levels of MDIG in A549/DDP cells were significantly higher compared with those in A549 cells, and that the protein expression levels of MDIG increased in a dose-dependent manner with increasing DDP concentrations. 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate 252-255 ribosomal oxygenase 2 Homo sapiens 194-198 31579066-5 2019 Overexpression of MDIG in A549 and A549/DDP cells led to an increase in the IC50 value, whereas silencing of MDIG led to a clear reduction in the IC50 value. 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate 40-43 ribosomal oxygenase 2 Homo sapiens 18-22 31579066-6 2019 The overexpression of MDIG in the A549 and A549/DDP cells markedly upregulated the mRNA and protein expression levels of ABCB1, ABCC1, ABCG2, WNT family member 5A, WNT family member 3A and active beta-catenin, and these were markedly decreased following MDIG silencing. 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate 48-51 ribosomal oxygenase 2 Homo sapiens 22-26 31579066-7 2019 Taken together, these results demonstrated that the DDP resistance of lung adenocarcinoma may be associated with an upregulation of MDIG expression, and that the expression levels of MDIG are positively associated with the degree of DDP resistance. 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate 52-55 ribosomal oxygenase 2 Homo sapiens 132-136 31579066-7 2019 Taken together, these results demonstrated that the DDP resistance of lung adenocarcinoma may be associated with an upregulation of MDIG expression, and that the expression levels of MDIG are positively associated with the degree of DDP resistance. 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate 233-236 ribosomal oxygenase 2 Homo sapiens 183-187 31579066-8 2019 Furthermore, MDIG promoted the expression of ABC transporters in tumor cells by activating the WNT/beta-catenin signaling pathway, which may, in turn, lead to DDP resistance in lung adenocarcinoma. 2-dimethylaminoethyl(dimethylamido)phosphonofluoridate 159-162 ribosomal oxygenase 2 Homo sapiens 13-17 31165872-9 2019 We further demonstrated that a pan jumonji histone demethylase inhibitor, JIB-04, inhibits MINA53-mediated demethylation of H3K36me3, and JIB-04 synergizes with other latency-reversing agents (LRAs) to reactivate latent HIV-1. jib 74-77 ribosomal oxygenase 2 Homo sapiens 91-97 31165872-9 2019 We further demonstrated that a pan jumonji histone demethylase inhibitor, JIB-04, inhibits MINA53-mediated demethylation of H3K36me3, and JIB-04 synergizes with other latency-reversing agents (LRAs) to reactivate latent HIV-1. JIB-04 74-80 ribosomal oxygenase 2 Homo sapiens 91-97 31003515-1 2019 BACKGROUND: The objective of the demonstration project for type 2 diabetes prevention in the Barranquilla and Juan Mina (DEMOJUAN) study was to investigate the extent to which it is possible to reach normal glucose metabolism with early lifestyle interventions in people at high risk of type 2 diabetes (prediabetes), compared with those who receive standard usual care. Glucose 207-214 ribosomal oxygenase 2 Homo sapiens 115-119 30546450-8 2018 Results of the MTT assay showed mdig siRNA could significantly reduce the proliferation ability of NCI-H1650 cells. monooxyethylene trimethylolpropane tristearate 15-18 ribosomal oxygenase 2 Homo sapiens 32-36 29914368-3 2018 The ribosomal oxygenases RIOX1 (NO66) and RIOX2 (MINA53) modify ribosomal proteins by histidine hydroxylation. Histidine 86-95 ribosomal oxygenase 2 Homo sapiens 49-55 30333481-7 2018 We further applied a genotoxic drug Doxorubicin and found that MINA53 deficiency sensitized glioblastoma cells to Doxorubicin. Doxorubicin 36-47 ribosomal oxygenase 2 Homo sapiens 63-69 30333481-7 2018 We further applied a genotoxic drug Doxorubicin and found that MINA53 deficiency sensitized glioblastoma cells to Doxorubicin. Doxorubicin 114-125 ribosomal oxygenase 2 Homo sapiens 63-69 26169781-0 2015 Maternal vitamin D supplementation during pregnancy and lactation to promote infant growth in Dhaka, Bangladesh (MDIG trial): study protocol for a randomized controlled trial. Vitamin D 9-18 ribosomal oxygenase 2 Homo sapiens 113-117 26293673-2 2015 On SDS-PAGE gels, three to five unique protein bands were consistently observed in the complexes pulled-down by mdig antibody, but not the control IgG. Sodium Dodecyl Sulfate 3-6 ribosomal oxygenase 2 Homo sapiens 112-116 28471446-6 2017 MDIG was also found to be closely related to the sorafenib resistance of HCC cells in vitro. Sorafenib 49-58 ribosomal oxygenase 2 Homo sapiens 0-4 24505346-3 2014 In this report, we demonstrated that overexpression of mdig decreased the nuclear staining signal by 4",6-diamidino-2-phenylindole (DAPI), along with a considerable enhancement in cell proliferation. DAPI 101-130 ribosomal oxygenase 2 Homo sapiens 55-59 24814345-4 2014 In Escherichia coli, YcfD catalyses arginine hydroxylation in the ribosomal protein L16; in humans, MYC-induced nuclear antigen (MINA53; also known as MINA) and nucleolar protein 66 (NO66) catalyse histidine hydroxylation in the ribosomal proteins RPL27A and RPL8, respectively. Arginine 36-44 ribosomal oxygenase 2 Homo sapiens 100-127 24434654-4 2014 By using human bronchial epithelial cells and human lung cancer cell lines, we showed that arsenic was able to induce expression of mdig. Arsenic 91-98 ribosomal oxygenase 2 Homo sapiens 132-136 24434654-5 2014 We further demonstrated that this mdig induction by arsenic was partially dependent on the JNK and STAT3 signaling pathways. Arsenic 52-59 ribosomal oxygenase 2 Homo sapiens 34-38 24434654-6 2014 Disruption of the JNK or STAT3 by either chemical inhibitors or siRNAs diminished arsenic-induced accumulation of mdig mRNA and protein. Arsenic 82-89 ribosomal oxygenase 2 Homo sapiens 114-118 24434654-7 2014 Furthermore, we also showed that microRNA-21 (miR-21) and Akt were down-stream effectors of the JNK and STAT3 signaling pathways in arsenic-induced mdig expression. Arsenic 132-139 ribosomal oxygenase 2 Homo sapiens 148-152 24434654-8 2014 Transfection of the cells with anti-miR-21 or pre-treatment of the cells with Akt inhibitor blunted mdig induction by arsenic. Arsenic 118-125 ribosomal oxygenase 2 Homo sapiens 100-104 24434654-10 2014 Taken together, our data suggest that mdig may play important roles on the pathogenesis of arsenic-induced lung cancer and that JNK and STAT3 signaling pathways are essential in mediating arsenic-induced mdig expression. Arsenic 91-98 ribosomal oxygenase 2 Homo sapiens 38-42 24434654-10 2014 Taken together, our data suggest that mdig may play important roles on the pathogenesis of arsenic-induced lung cancer and that JNK and STAT3 signaling pathways are essential in mediating arsenic-induced mdig expression. Arsenic 188-195 ribosomal oxygenase 2 Homo sapiens 204-208 24505346-3 2014 In this report, we demonstrated that overexpression of mdig decreased the nuclear staining signal by 4",6-diamidino-2-phenylindole (DAPI), along with a considerable enhancement in cell proliferation. DAPI 132-136 ribosomal oxygenase 2 Homo sapiens 55-59 23319753-0 2013 Q&A: Mina Bissell on tumors as organs. q& 0-5 ribosomal oxygenase 2 Homo sapiens 9-13 23965803-3 2013 Although mdig can only cause a marginal decrease of the total histone H3 lysine 9 trimethylation (H3K9me3), a significant reduction of H3K9me3 in the promoter region of H19, the paternally imprinted but maternally expressed gene transcribing a large intergenic non-coding RNA (lincRNA), was observed in the cells with mdig overexpression. Lysine 73-79 ribosomal oxygenase 2 Homo sapiens 9-13 23389654-2 2013 A culture-independent molecular analysis was performed to assess the prokaryotic diversity and community structural changes of the tropical historically metal-contaminated Mina stream (MS) and the relatively pristine Mutuca stream (MTS) sediments. Metals 153-158 ribosomal oxygenase 2 Homo sapiens 172-176 22783387-9 2012 In addition, increased levels of expression of Mina53 in CCA were positively associated with Ki67 levels (r=0.801, P<0.01, as calculated by association analysis). ki67 93-97 ribosomal oxygenase 2 Homo sapiens 47-53 21631300-1 2011 The single-nucleotide polymorphisms (SNPs) of the Mina gene in animals are associated with the development of Th2-mediated diseases. th2 110-113 ribosomal oxygenase 2 Homo sapiens 50-54 23012141-3 2007 METHODOLOGY: A case was defined as any individual who developed diarrhea with or without abdominal pain after eating at the camp in Mina on 3(rd) January 2006. Cyclic AMP 124-128 ribosomal oxygenase 2 Homo sapiens 132-136 19502796-0 2009 Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3. trimethyllysine 72-89 ribosomal oxygenase 2 Homo sapiens 43-47 19502796-4 2009 Gene silencing or overexpression of mdig revealed that mdig is involved in demethylation of tri-methyl lysine 9 on histone H3, leading to an increase in ribosomal RNA expression. trimethyllysine 92-109 ribosomal oxygenase 2 Homo sapiens 36-40 19502796-4 2009 Gene silencing or overexpression of mdig revealed that mdig is involved in demethylation of tri-methyl lysine 9 on histone H3, leading to an increase in ribosomal RNA expression. trimethyllysine 92-109 ribosomal oxygenase 2 Homo sapiens 55-59 19502796-5 2009 The transcriptional regulation of ribosomal RNA gene by mdig is achieved through abrogating tri-methyl lysine 9 on histone H3 and enhancing RNA polymerase I occupancy in the promoter region of the ribosomal RNA gene as demonstrated by chromatin immunoprecipitation. Lysine 103-109 ribosomal oxygenase 2 Homo sapiens 56-60 19502796-6 2009 The pronounced expression of mdig in lung cancer tissues but not normal lung tissues, thus, suggests that mdig possesses oncogenic property through antagonizing tri-methyl lysine 9 on histone H3 and promoting ribosomal RNA synthesis. trimethyllysine 161-178 ribosomal oxygenase 2 Homo sapiens 29-33 19502796-6 2009 The pronounced expression of mdig in lung cancer tissues but not normal lung tissues, thus, suggests that mdig possesses oncogenic property through antagonizing tri-methyl lysine 9 on histone H3 and promoting ribosomal RNA synthesis. trimethyllysine 161-178 ribosomal oxygenase 2 Homo sapiens 106-110 17317935-5 2006 In well-differentiated GSCC with pearl formation, Mina53 was negative at the center of the clearly keratinized cancer nest, but positive in the nuclei of cells in the periphery and adjacent area of the cancer nest. pearl 33-38 ribosomal oxygenase 2 Homo sapiens 50-56 15534111-9 2004 When formalin-fixed specimens from 52 patients with ESCC were stained immunohistochemically, it was found that Mina53 was highly expressed in 83% of specimens. Formaldehyde 5-13 ribosomal oxygenase 2 Homo sapiens 111-117 15897898-5 2005 The inducible expression of mdig could be observed in A549 cells exposed to silica particles in a time-dependent manner. Silicon Dioxide 76-82 ribosomal oxygenase 2 Homo sapiens 28-32 15897898-9 2005 Silencing mdig mRNA expression in A549 lung cancer cells by siRNA-mediated RNA interference inhibits cell proliferation and sensitizes the cells to silica-induced cytotoxicity. Silicon Dioxide 148-154 ribosomal oxygenase 2 Homo sapiens 10-14 15819408-6 2005 Immunolocalization studies revealed that protein NO52 is highly concentrated in the granular component of nucleoli and this characteristic intranuclear distribution is significantly affected by treatment of cells with (i) RNase A, (ii) actinomycin D and (iii) serum starvation. Dactinomycin 236-249 ribosomal oxygenase 2 Homo sapiens 49-53 12547635-3 2003 The sediment samples from the upstream area facing Mina Al-Ahmadi refinery to Shuaiba Harbor were heavily polluted with polycyclic aromatic hydrocarbons (PAHs) possibly due to the higher depth in the area created for a navigational channel to the harbor. Polycyclic Aromatic Hydrocarbons 120-152 ribosomal oxygenase 2 Homo sapiens 51-55 12091391-5 2002 When expression of c-myc was reduced in human promyelocytic leukemia HL60 cells by phorbol 12-myristate 13-acetate, the expression of mina53 mRNA and protein was reduced. Tetradecanoylphorbol Acetate 83-114 ribosomal oxygenase 2 Homo sapiens 134-140 9316079-1 1997 Two anomeric analogues of glucose labelled with 123 iodine in position 6, proposed as tracers of glucose transport in vivo, have been synthesized: alpha- and beta-methyl-6-deoxy-6-iodo-D-glucopyranoside (alpha MDIG and beta MDIG). Glucose 26-33 ribosomal oxygenase 2 Homo sapiens 210-214 9316079-1 1997 Two anomeric analogues of glucose labelled with 123 iodine in position 6, proposed as tracers of glucose transport in vivo, have been synthesized: alpha- and beta-methyl-6-deoxy-6-iodo-D-glucopyranoside (alpha MDIG and beta MDIG). Glucose 26-33 ribosomal oxygenase 2 Homo sapiens 224-228 9316079-7 1997 alpha MDIG uptake was lowered in the presence of glucose transport inhibitors in each experimental model. Glucose 49-56 ribosomal oxygenase 2 Homo sapiens 6-10 9316079-9 1997 Only alpha MDIG interacts with the glucose transporter, and thus could be used to estimate glucose transport in vivo. Glucose 35-42 ribosomal oxygenase 2 Homo sapiens 11-15 34843649-4 2021 These assays enabled the identification of 2-(aryl)alkylthio-3,4-dihydro-4-oxoypyrimidine-5-carboxylic acids as potent MINA53 inhibitors, with selectivity over NO66 and other JmjC oxygenases. 2-(aryl)alkylthio-3,4-dihydro-4-oxoypyrimidine-5-carboxylic acids 43-108 ribosomal oxygenase 2 Homo sapiens 119-125 34843649-5 2021 Crystallographic studies with the JmjC demethylase KDM5B revealed active site binding but without direct metal chelation; however, molecular modeling investigations indicated that the inhibitors bind to MINA53 by directly interacting with the iron cofactor. Iron 243-247 ribosomal oxygenase 2 Homo sapiens 203-209 33823236-0 2021 Cooperation between NRF2-mediated transcription and MDIG-dependent epigenetic modifications in arsenic-induced carcinogenesis and cancer stem cells. Arsenic 95-102 ribosomal oxygenase 2 Homo sapiens 52-56 33823236-3 2021 In this review, we discuss some recent discoveries showing how the transcription factor NRF2 and an epigenetic regulator, MDIG, contribute to the arsenic-induced generation of cancer stem-like cells (CSCs) as determined by applying CRISPR-Cas9 gene editing and chromosome immunoprecipitation followed by DNA sequencing (ChIP-seq). Arsenic 146-153 ribosomal oxygenase 2 Homo sapiens 122-126 34335974-0 2021 Environmentally-induced mdig contributes to the severity of COVID-19 through fostering expression of SARS-CoV-2 receptor NRPs and glycan metabolism. Polysaccharides 130-136 ribosomal oxygenase 2 Homo sapiens 24-28 34335974-4 2021 In the present report, we provided evidence showing that mdig, a previously reported environmentally-induced oncogene that antagonizes repressive trimethylation of histone proteins, is an important regulator for SARS-CoV-2 receptors neuropilin-1 (NRP1) and NRP2, cathepsins, glycan metabolism and inflammation, key determinants for viral infection and cytokine storm of the patients. Polysaccharides 275-281 ribosomal oxygenase 2 Homo sapiens 57-61 34335974-5 2021 Depletion of mdig in bronchial epithelial cells by CRISPR-Cas-9 gene editing resulted in a decreased expression of NRP1, NRP2, cathepsins, and genes involved in protein glycosylation and inflammation, largely due to a substantial enrichment of lysine 9 and/or lysine 27 trimethylation of histone H3 (H3K9me3/H3K27me3) on these genes as determined by ChIP-seq. Lysine 244-250 ribosomal oxygenase 2 Homo sapiens 13-17 34335974-5 2021 Depletion of mdig in bronchial epithelial cells by CRISPR-Cas-9 gene editing resulted in a decreased expression of NRP1, NRP2, cathepsins, and genes involved in protein glycosylation and inflammation, largely due to a substantial enrichment of lysine 9 and/or lysine 27 trimethylation of histone H3 (H3K9me3/H3K27me3) on these genes as determined by ChIP-seq. Lysine 260-266 ribosomal oxygenase 2 Homo sapiens 13-17 34335974-6 2021 Meanwhile, we also validated that environmental factor arsenic is able to induce mdig, NRP1 and NRP2, and genetic disruption of mdig lowered expression of NRP1 and NRP2. Arsenic 55-62 ribosomal oxygenase 2 Homo sapiens 81-85 34335974-6 2021 Meanwhile, we also validated that environmental factor arsenic is able to induce mdig, NRP1 and NRP2, and genetic disruption of mdig lowered expression of NRP1 and NRP2. Arsenic 55-62 ribosomal oxygenase 2 Homo sapiens 128-132 35583005-0 2022 MDIG, a 2-oxoglutarate-dependent oxygenase, acts as an oncogene and predicts the prognosis of multiple types of cancer. Ketoglutaric Acids 8-22 ribosomal oxygenase 2 Homo sapiens 0-4