PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
30049968-6	2018	A function in response to glucose availability is also suggested by synthetic genetic phenotypes of a rho5 deletion with gpr1, gpa2, and sch9 null mutants.	Glucose	26-33	Gpr1p	Saccharomyces cerevisiae S288C	121-125
30114904-4	2018	The yeast glucose activated GPCR-Gpr1 was chosen as a prototype to evolve novel glucose sensors.	Glucose	10-17	Gpr1p	Saccharomyces cerevisiae S288C	33-37
30114904-4	2018	The yeast glucose activated GPCR-Gpr1 was chosen as a prototype to evolve novel glucose sensors.	Glucose	80-87	Gpr1p	Saccharomyces cerevisiae S288C	33-37
29284676-2	2018	Glucose and other sugars are detected by a G protein-coupled receptor, Gpr1, as well as a pair of transporter-like proteins, Rgt2 and Snf3.	Glucose	0-7	Gpr1p	Saccharomyces cerevisiae S288C	71-75
29284676-2	2018	Glucose and other sugars are detected by a G protein-coupled receptor, Gpr1, as well as a pair of transporter-like proteins, Rgt2 and Snf3.	Sugars	18-24	Gpr1p	Saccharomyces cerevisiae S288C	71-75
23127800-5	2013	Remarkably, in a gpa2Delta, but not in a gpr1Delta mutant, active Ras accumulates in internal membranes and mitochondria, both when cells are growing on glucose medium or are starved, indicating that Gpa2, but not Gpr1 is required for the recruitment of Ras-GTP at the plasma membrane and in the nucleus.	Radium	66-69	Gpr1p	Saccharomyces cerevisiae S288C	214-218
25044394-0	2014	Pheromone responsiveness is regulated by components of the Gpr1p-mediated glucose sensing pathway in Saccharomyces cerevisiae.	Glucose	74-81	Gpr1p	Saccharomyces cerevisiae S288C	59-64
25044394-2	2014	In this study, we examined one such system in Saccharomyces cerevisiae, involving a glucose-sensing pathway mediated by Gpr1p and the pheromone-induced mating pathway.	Glucose	84-91	Gpr1p	Saccharomyces cerevisiae S288C	120-125
25044394-5	2014	Deletion of the low-affinity glucose receptor, Gpr1p, eliminated this glucose-induced recovery of pheromone responsiveness.	Glucose	29-36	Gpr1p	Saccharomyces cerevisiae S288C	47-52
25044394-10	2014	These data suggest that activity of the GPCR-mediated mating pathway in S. cerevisiae is modulated by extracellular glucose concentrations through the only other GPCR in MATa cells, Gpr1p.	Glucose	116-123	Gpr1p	Saccharomyces cerevisiae S288C	182-187
23495665-5	2013	A novel function of the Gpr1/cAMP/PKA pathway was identified in glucose-starved cells: during starvation the Gpr1/cAMP/PKA pathway is required to maintain Hxt5p activity in the absence of glucose-induced cAMP spiking.	Glucose	188-195	Gpr1p	Saccharomyces cerevisiae S288C	24-28
23495665-5	2013	A novel function of the Gpr1/cAMP/PKA pathway was identified in glucose-starved cells: during starvation the Gpr1/cAMP/PKA pathway is required to maintain Hxt5p activity in the absence of glucose-induced cAMP spiking.	Cyclic AMP	114-118	Gpr1p	Saccharomyces cerevisiae S288C	24-28
23495665-5	2013	A novel function of the Gpr1/cAMP/PKA pathway was identified in glucose-starved cells: during starvation the Gpr1/cAMP/PKA pathway is required to maintain Hxt5p activity in the absence of glucose-induced cAMP spiking.	Cyclic AMP	114-118	Gpr1p	Saccharomyces cerevisiae S288C	109-113
23495665-3	2013	cAMP and glucose FRET (fluorescence resonance energy transfer) sensors were used to identify three signalling pathways that co-operate in the anticipatory Hxt5p activity in glucose-starved cells: as expected the Snf1 (sucrose nonfermenting 1) AMP kinase pathway, but, surprisingly, the sugar-dependent G-protein-coupled Gpr1 (G-protein-coupled receptor 1)/cAMP/PKA (protein kinase A) pathway and the Pho85 (phosphate metabolism 85)/Plc (phospholipase C) 6/7 pathway.	Glucose	173-180	Gpr1p	Saccharomyces cerevisiae S288C	320-324
23495665-3	2013	cAMP and glucose FRET (fluorescence resonance energy transfer) sensors were used to identify three signalling pathways that co-operate in the anticipatory Hxt5p activity in glucose-starved cells: as expected the Snf1 (sucrose nonfermenting 1) AMP kinase pathway, but, surprisingly, the sugar-dependent G-protein-coupled Gpr1 (G-protein-coupled receptor 1)/cAMP/PKA (protein kinase A) pathway and the Pho85 (phosphate metabolism 85)/Plc (phospholipase C) 6/7 pathway.	Glucose	173-180	Gpr1p	Saccharomyces cerevisiae S288C	326-354
23495665-4	2013	Gpr1/cAMP/PKA are key elements of a G-protein-coupled sugar response pathway that produces a transient cAMP peak to induce growth-related genes.	Cyclic AMP	5-9	Gpr1p	Saccharomyces cerevisiae S288C	0-4
23495665-4	2013	Gpr1/cAMP/PKA are key elements of a G-protein-coupled sugar response pathway that produces a transient cAMP peak to induce growth-related genes.	Sugars	54-59	Gpr1p	Saccharomyces cerevisiae S288C	0-4
23495665-4	2013	Gpr1/cAMP/PKA are key elements of a G-protein-coupled sugar response pathway that produces a transient cAMP peak to induce growth-related genes.	Cyclic AMP	103-107	Gpr1p	Saccharomyces cerevisiae S288C	0-4
23495665-5	2013	A novel function of the Gpr1/cAMP/PKA pathway was identified in glucose-starved cells: during starvation the Gpr1/cAMP/PKA pathway is required to maintain Hxt5p activity in the absence of glucose-induced cAMP spiking.	Cyclic AMP	29-33	Gpr1p	Saccharomyces cerevisiae S288C	24-28
23495665-5	2013	A novel function of the Gpr1/cAMP/PKA pathway was identified in glucose-starved cells: during starvation the Gpr1/cAMP/PKA pathway is required to maintain Hxt5p activity in the absence of glucose-induced cAMP spiking.	Cyclic AMP	29-33	Gpr1p	Saccharomyces cerevisiae S288C	109-113
23495665-5	2013	A novel function of the Gpr1/cAMP/PKA pathway was identified in glucose-starved cells: during starvation the Gpr1/cAMP/PKA pathway is required to maintain Hxt5p activity in the absence of glucose-induced cAMP spiking.	Glucose	64-71	Gpr1p	Saccharomyces cerevisiae S288C	24-28
23495665-5	2013	A novel function of the Gpr1/cAMP/PKA pathway was identified in glucose-starved cells: during starvation the Gpr1/cAMP/PKA pathway is required to maintain Hxt5p activity in the absence of glucose-induced cAMP spiking.	Glucose	64-71	Gpr1p	Saccharomyces cerevisiae S288C	109-113
23495665-5	2013	A novel function of the Gpr1/cAMP/PKA pathway was identified in glucose-starved cells: during starvation the Gpr1/cAMP/PKA pathway is required to maintain Hxt5p activity in the absence of glucose-induced cAMP spiking.	Cyclic AMP	114-118	Gpr1p	Saccharomyces cerevisiae S288C	24-28
23495665-5	2013	A novel function of the Gpr1/cAMP/PKA pathway was identified in glucose-starved cells: during starvation the Gpr1/cAMP/PKA pathway is required to maintain Hxt5p activity in the absence of glucose-induced cAMP spiking.	Cyclic AMP	114-118	Gpr1p	Saccharomyces cerevisiae S288C	109-113
22219709-2	2010	Yeast cells have evolved several mechanisms for monitoring the level of glucose in their habitat and respond quickly to frequent changes in the sugar availability in the environment: the cAMP/PKA pathways (with its two branches comprising Ras and the Gpr1/Gpa2 module), the Rgt2/Snf3-Rgt1 pathway and the main repression pathway involving the kinase Snf1.	Sugars	144-149	Gpr1p	Saccharomyces cerevisiae S288C	251-255
22660623-4	2012	We found that the regulation of spore formation by acetate takes place after commitment to meiosis and depends on PKA and appropriate A kinase activation by Ras/Cyr1 adenylyl cyclase but not by activation through the Gpa2/Gpr1 branch.	Acetates	51-58	Gpr1p	Saccharomyces cerevisiae S288C	222-226
22575457-2	2012	cAMP is produced by adenylate cyclase, which is activated both by Gpr1/Gpa2 system and Ras proteins, regulated by Cdc25/Sdc25 guanine exchange factors and Ira GTPase activator proteins.	Cyclic AMP	0-4	Gpr1p	Saccharomyces cerevisiae S288C	66-70
22575457-2	2012	cAMP is produced by adenylate cyclase, which is activated both by Gpr1/Gpa2 system and Ras proteins, regulated by Cdc25/Sdc25 guanine exchange factors and Ira GTPase activator proteins.	Guanine	126-133	Gpr1p	Saccharomyces cerevisiae S288C	66-70
22219709-2	2010	Yeast cells have evolved several mechanisms for monitoring the level of glucose in their habitat and respond quickly to frequent changes in the sugar availability in the environment: the cAMP/PKA pathways (with its two branches comprising Ras and the Gpr1/Gpa2 module), the Rgt2/Snf3-Rgt1 pathway and the main repression pathway involving the kinase Snf1.	Cyclic AMP	187-191	Gpr1p	Saccharomyces cerevisiae S288C	251-255
18559076-5	2008	Glucose sensing involves the plasma membrane proteins Snf3, Rgt2 and Gpr1 and the glucose-phosphorylating enzyme Hxk2, as well as other regulatory elements whose functions are still incompletely understood.	Glucose	0-7	Gpr1p	Saccharomyces cerevisiae S288C	69-73
18622617-5	2008	Low glucose also induced pseudohyphae in mep2gpr1 but not mep2gpa2 strain suggesting that GPR1 inhibits pseudohyphae by inhibiting GPA2 function.	Glucose	4-11	Gpr1p	Saccharomyces cerevisiae S288C	90-94
19651853-4	2009	Advanced bioinformatic analysis for detection of homology in distantly related proteins identifies the nontransporting glucose transceptor Rgt2 as the closest homologue of the glucose-sensing GPCR Gpr1 in yeast.	Glucose	119-126	Gpr1p	Saccharomyces cerevisiae S288C	197-201
19651853-4	2009	Advanced bioinformatic analysis for detection of homology in distantly related proteins identifies the nontransporting glucose transceptor Rgt2 as the closest homologue of the glucose-sensing GPCR Gpr1 in yeast.	Glucose	176-183	Gpr1p	Saccharomyces cerevisiae S288C	197-201
19791505-2	2009	In this study, we have shown that the transcription of Ty2 is partially dependent on the membrane-bound glucose sensors Gpr1p and Mth1p in Saccharomyces cerevisiae.	Glucose	104-111	Gpr1p	Saccharomyces cerevisiae S288C	120-125
18096414-0	2008	G-protein-coupled receptor Gpr1 and G-protein Gpa2 of cAMP-dependent signaling pathway are involved in glucose-induced pexophagy in the yeast Saccharomyces cerevisiae.	Cyclic AMP	54-58	Gpr1p	Saccharomyces cerevisiae S288C	27-31
18096414-3	2008	We have found that in Saccharomyces cerevisiae, defect of G-protein-coupled receptor Gpr1 and G-protein Gpa2, both the components of cAMP-signaling pathway, strongly suppressed glucose-induced degradation of matrix peroxisomal protein thiolase.	Cyclic AMP	133-137	Gpr1p	Saccharomyces cerevisiae S288C	85-89
18096414-0	2008	G-protein-coupled receptor Gpr1 and G-protein Gpa2 of cAMP-dependent signaling pathway are involved in glucose-induced pexophagy in the yeast Saccharomyces cerevisiae.	Glucose	103-110	Gpr1p	Saccharomyces cerevisiae S288C	27-31
18096414-3	2008	We have found that in Saccharomyces cerevisiae, defect of G-protein-coupled receptor Gpr1 and G-protein Gpa2, both the components of cAMP-signaling pathway, strongly suppressed glucose-induced degradation of matrix peroxisomal protein thiolase.	Glucose	177-184	Gpr1p	Saccharomyces cerevisiae S288C	85-89
18227642-4	2008	Most likely, glucose is sensed for pexophagy using the Gpr1 sensor involved in the PKA-cAMP signaling pathway.	Glucose	13-20	Gpr1p	Saccharomyces cerevisiae S288C	55-59
18096414-4	2008	We conclude that proteins Gpr1 and Gpa2 are involved in glucose sensing and signal transduction during pexophagy process in yeast.	Glucose	56-63	Gpr1p	Saccharomyces cerevisiae S288C	26-30
18227642-4	2008	Most likely, glucose is sensed for pexophagy using the Gpr1 sensor involved in the PKA-cAMP signaling pathway.	Cyclic AMP	87-91	Gpr1p	Saccharomyces cerevisiae S288C	55-59
18227642-2	2008	Recently, we have found that defects in the S. cerevisiae PKA-cAMP signaling pathway due to knockouts of GPR1 and/or GPA2 suppressed glucose-induced degradation of peroxisomal thiolase.	Cyclic AMP	62-66	Gpr1p	Saccharomyces cerevisiae S288C	105-109
18268028-3	2008	To further aggravate the deregulation in the pathogen, we have additionally deleted the GPR1 gene, encoding the nutrient receptor that activates the cyclic AMP-protein kinase A signaling pathway, which negatively regulates trehalose accumulation in yeasts.	Trehalose	223-232	Gpr1p	Saccharomyces cerevisiae S288C	88-92
18227642-2	2008	Recently, we have found that defects in the S. cerevisiae PKA-cAMP signaling pathway due to knockouts of GPR1 and/or GPA2 suppressed glucose-induced degradation of peroxisomal thiolase.	Glucose	133-140	Gpr1p	Saccharomyces cerevisiae S288C	105-109
17890371-8	2008	In all strains and in all media, sucrose induction of filamentation is greatly diminished by deletion of the sucrose/glucose-sensing G-protein-coupled receptor Gpr1, whereas it has no effect on induction by maltose and maltotriose.	Sucrose	33-40	Gpr1p	Saccharomyces cerevisiae S288C	160-164
17890371-8	2008	In all strains and in all media, sucrose induction of filamentation is greatly diminished by deletion of the sucrose/glucose-sensing G-protein-coupled receptor Gpr1, whereas it has no effect on induction by maltose and maltotriose.	Sucrose	109-116	Gpr1p	Saccharomyces cerevisiae S288C	160-164
17890371-8	2008	In all strains and in all media, sucrose induction of filamentation is greatly diminished by deletion of the sucrose/glucose-sensing G-protein-coupled receptor Gpr1, whereas it has no effect on induction by maltose and maltotriose.	Glucose	117-124	Gpr1p	Saccharomyces cerevisiae S288C	160-164
17890371-10	2008	In addition, sucrose is the only alpha-glucoside sugar capable of rapidly inducing FLO11 expression in a Gpr1-dependent manner, reflecting the sensitivity of Gpr1 for this sugar and its involvement in rapid sucrose signaling.	Sucrose	13-20	Gpr1p	Saccharomyces cerevisiae S288C	105-109
17890371-10	2008	In addition, sucrose is the only alpha-glucoside sugar capable of rapidly inducing FLO11 expression in a Gpr1-dependent manner, reflecting the sensitivity of Gpr1 for this sugar and its involvement in rapid sucrose signaling.	Sucrose	13-20	Gpr1p	Saccharomyces cerevisiae S288C	158-162
17890371-10	2008	In addition, sucrose is the only alpha-glucoside sugar capable of rapidly inducing FLO11 expression in a Gpr1-dependent manner, reflecting the sensitivity of Gpr1 for this sugar and its involvement in rapid sucrose signaling.	alpha-glucoside sugar	33-54	Gpr1p	Saccharomyces cerevisiae S288C	105-109
17890371-10	2008	In addition, sucrose is the only alpha-glucoside sugar capable of rapidly inducing FLO11 expression in a Gpr1-dependent manner, reflecting the sensitivity of Gpr1 for this sugar and its involvement in rapid sucrose signaling.	alpha-glucoside sugar	33-54	Gpr1p	Saccharomyces cerevisiae S288C	158-162
17890371-10	2008	In addition, sucrose is the only alpha-glucoside sugar capable of rapidly inducing FLO11 expression in a Gpr1-dependent manner, reflecting the sensitivity of Gpr1 for this sugar and its involvement in rapid sucrose signaling.	Sugars	49-54	Gpr1p	Saccharomyces cerevisiae S288C	105-109
17890371-10	2008	In addition, sucrose is the only alpha-glucoside sugar capable of rapidly inducing FLO11 expression in a Gpr1-dependent manner, reflecting the sensitivity of Gpr1 for this sugar and its involvement in rapid sucrose signaling.	Sugars	49-54	Gpr1p	Saccharomyces cerevisiae S288C	158-162
17890371-10	2008	In addition, sucrose is the only alpha-glucoside sugar capable of rapidly inducing FLO11 expression in a Gpr1-dependent manner, reflecting the sensitivity of Gpr1 for this sugar and its involvement in rapid sucrose signaling.	Sucrose	207-214	Gpr1p	Saccharomyces cerevisiae S288C	105-109
17890371-10	2008	In addition, sucrose is the only alpha-glucoside sugar capable of rapidly inducing FLO11 expression in a Gpr1-dependent manner, reflecting the sensitivity of Gpr1 for this sugar and its involvement in rapid sucrose signaling.	Sucrose	207-214	Gpr1p	Saccharomyces cerevisiae S288C	158-162
17727662-3	2007	Our results suggest that an unregulated, low Ras guanine nucleotide exchange factor activity allows a normal glucose-induced cAMP signal that appears to be mediated mainly by the Gpr1/Gpa2 system, but it was not enough to sustain the glucose-induced increase of Ras2-GTP normally observed in a wild-type strain.	Glucose	109-116	Gpr1p	Saccharomyces cerevisiae S288C	179-183
17727662-3	2007	Our results suggest that an unregulated, low Ras guanine nucleotide exchange factor activity allows a normal glucose-induced cAMP signal that appears to be mediated mainly by the Gpr1/Gpa2 system, but it was not enough to sustain the glucose-induced increase of Ras2-GTP normally observed in a wild-type strain.	Cyclic AMP	125-129	Gpr1p	Saccharomyces cerevisiae S288C	179-183
16924114-3	2006	Yeast cells (Saccharomyces cerevisiae) contain a glucose/sucrose-sensitive seven-transmembrane domain receptor, Gpr1, that was proposed to activate adenylate cyclase through the G(alpha) protein Gpa2.	Glucose	49-56	Gpr1p	Saccharomyces cerevisiae S288C	112-116
17700863-2	2007	Use of the disaccharide maltose as the principal carbon source, in contrast to the preferred nutrient monosaccharide glucose, has been shown to induce a hyper-filamentous growth phenotype in a strain deficient for GPA2 which codes for a Galpha protein component that interacts with the glucose-sensing receptor Gpr1p to regulate filamentous growth.	Disaccharides	11-23	Gpr1p	Saccharomyces cerevisiae S288C	311-316
17700863-2	2007	Use of the disaccharide maltose as the principal carbon source, in contrast to the preferred nutrient monosaccharide glucose, has been shown to induce a hyper-filamentous growth phenotype in a strain deficient for GPA2 which codes for a Galpha protein component that interacts with the glucose-sensing receptor Gpr1p to regulate filamentous growth.	Maltose	24-31	Gpr1p	Saccharomyces cerevisiae S288C	311-316
17233767-0	2007	Mutations at different sites in members of the Gpr1/Fun34/YaaH protein family cause hypersensitivity to acetic acid in Saccharomyces cerevisiae as well as in Yarrowia lipolytica.	Acetic Acid	104-115	Gpr1p	Saccharomyces cerevisiae S288C	47-51
17233767-2	2007	Trans-dominant mutations in the GPR1 gene result in acetic acid sensitivity of cells at low pH.	Acetic Acid	52-63	Gpr1p	Saccharomyces cerevisiae S288C	32-36
17233767-3	2007	Moreover, Gpr1p is subjected to phosphorylation at serine-37 in a carbon source-dependent manner.	Serine	51-57	Gpr1p	Saccharomyces cerevisiae S288C	10-15
17233767-3	2007	Moreover, Gpr1p is subjected to phosphorylation at serine-37 in a carbon source-dependent manner.	Carbon	66-72	Gpr1p	Saccharomyces cerevisiae S288C	10-15
17233767-4	2007	Here we show that several mutations within the ORFs of the GPR1 orthologues of Saccharomyces cerevisiae, YCR010c (ATO1) and YNR002c (ATO2), also trans-dominantly induce acetic acid hypersensitivity in this yeast.	Acetic Acid	169-180	Gpr1p	Saccharomyces cerevisiae S288C	59-63
17233767-5	2007	We demonstrate that the C-termini of mutated Gpr1p, Ycr010cp and Ynr002cp are necessary for the triggering of acetic acid sensitivity.	Acetic Acid	110-121	Gpr1p	Saccharomyces cerevisiae S288C	45-50
16844691-1	2006	The yeast Saccharomyces cerevisiae deploys two different types of glucose sensors on its cell surface that operate in distinct glucose signaling pathways: the glucose transporter-like Snf3 and Rgt2 proteins and the Gpr1 receptor that is coupled to Gpa2, a G-protein alpha subunit.	Glucose	66-73	Gpr1p	Saccharomyces cerevisiae S288C	215-219
16844691-1	2006	The yeast Saccharomyces cerevisiae deploys two different types of glucose sensors on its cell surface that operate in distinct glucose signaling pathways: the glucose transporter-like Snf3 and Rgt2 proteins and the Gpr1 receptor that is coupled to Gpa2, a G-protein alpha subunit.	Glucose	127-134	Gpr1p	Saccharomyces cerevisiae S288C	215-219
16844691-3	2006	We have found that the cAMP-dependent protein kinase A (PKA), which is activated by the Gpr1/Gpa2 glucose-sensing pathway and by a glucose-sensing pathway that works through Ras1 and Ras2, catalyzes phosphorylation of Rgt1 and regulates its function.	Cyclic AMP	23-27	Gpr1p	Saccharomyces cerevisiae S288C	88-92
16844691-3	2006	We have found that the cAMP-dependent protein kinase A (PKA), which is activated by the Gpr1/Gpa2 glucose-sensing pathway and by a glucose-sensing pathway that works through Ras1 and Ras2, catalyzes phosphorylation of Rgt1 and regulates its function.	Glucose	98-105	Gpr1p	Saccharomyces cerevisiae S288C	88-92
17311583-1	2007	The glucose sensors Gpr1, Snf3 and Rgt2 generate the earliest signals produced by glucose in yeast.	Glucose	4-11	Gpr1p	Saccharomyces cerevisiae S288C	20-24
17311583-1	2007	The glucose sensors Gpr1, Snf3 and Rgt2 generate the earliest signals produced by glucose in yeast.	Glucose	82-89	Gpr1p	Saccharomyces cerevisiae S288C	20-24
17311583-2	2007	We showed that a lack of Gpr1 or Snf3/Rgt2 decreased by twofold the glucose induction of SUC2, but had no effect on the induction of pyruvate decarboxylase (Pdc).	Glucose	68-75	Gpr1p	Saccharomyces cerevisiae S288C	25-29
16924114-3	2006	Yeast cells (Saccharomyces cerevisiae) contain a glucose/sucrose-sensitive seven-transmembrane domain receptor, Gpr1, that was proposed to activate adenylate cyclase through the G(alpha) protein Gpa2.	Sucrose	57-64	Gpr1p	Saccharomyces cerevisiae S288C	112-116
16030250-2	2005	The Saccharomyces cerevisiae GPCR Gpr1 and associated Galpha subunit Gpa2 sense extracellular carbon sources (including glucose) to govern filamentous growth.	Carbon	94-100	Gpr1p	Saccharomyces cerevisiae S288C	34-38
16030250-2	2005	The Saccharomyces cerevisiae GPCR Gpr1 and associated Galpha subunit Gpa2 sense extracellular carbon sources (including glucose) to govern filamentous growth.	Glucose	120-127	Gpr1p	Saccharomyces cerevisiae S288C	34-38
12634328-0	2003	Characterization, localization and functional analysis of Gpr1p, a protein affecting sensitivity to acetic acid in the yeast Yarrowia lipolytica.	Acetic Acid	100-111	Gpr1p	Saccharomyces cerevisiae S288C	58-63
15975858-0	2005	Carbon source dependent phosphorylation of the Gpr1 protein in the yeast Yarrowia lipolytica.	Carbon	0-6	Gpr1p	Saccharomyces cerevisiae S288C	47-51
15975858-2	2005	Gpr1p seems to be involved in acetic acid adaptation at low pH values.	Acetic Acid	30-41	Gpr1p	Saccharomyces cerevisiae S288C	0-5
15975858-3	2005	Here we show that Gpr1p is subjected to phosphorylation in dependence on the carbon source.	Carbon	77-83	Gpr1p	Saccharomyces cerevisiae S288C	18-23
15975858-4	2005	Exhaustion of the carbon source resulted in a complete dephosphorylation of Gpr1p, whereas addition of a new carbon source caused the phosphorylation of Gpr1p.	Carbon	18-24	Gpr1p	Saccharomyces cerevisiae S288C	76-81
15975858-4	2005	Exhaustion of the carbon source resulted in a complete dephosphorylation of Gpr1p, whereas addition of a new carbon source caused the phosphorylation of Gpr1p.	Carbon	109-115	Gpr1p	Saccharomyces cerevisiae S288C	153-158
15975858-5	2005	Almost all Gpr1p molecules became phosphorylated after addition of acetate, while other carbon sources only triggered the phosphorylation of about half of the Gpr1p molecules.	Acetates	67-74	Gpr1p	Saccharomyces cerevisiae S288C	11-16
15975858-5	2005	Almost all Gpr1p molecules became phosphorylated after addition of acetate, while other carbon sources only triggered the phosphorylation of about half of the Gpr1p molecules.	Carbon	88-94	Gpr1p	Saccharomyces cerevisiae S288C	159-164
15975858-7	2005	In spite of the clear effect of acetate/acetic acid on the level of phosphorylation of Gpr1p, no correlation of phosphorylation/dephosphorylation and acetic acid hypersensitivity, caused by mutations within Gpr1p, was detected.	Acetates	32-39	Gpr1p	Saccharomyces cerevisiae S288C	87-92
15975858-7	2005	In spite of the clear effect of acetate/acetic acid on the level of phosphorylation of Gpr1p, no correlation of phosphorylation/dephosphorylation and acetic acid hypersensitivity, caused by mutations within Gpr1p, was detected.	Acetic Acid	40-51	Gpr1p	Saccharomyces cerevisiae S288C	87-92
15743410-2	2005	Here, we present evidence that the Gpr1 receptor and Gpa2 Galpha subunit are required for both maintenance and modulation of cell size in response to glucose.	Glucose	150-157	Gpr1p	Saccharomyces cerevisiae S288C	35-39
15743410-3	2005	In the presence of glucose, mutants lacking GPR1 or GPA2 gene showed smaller cells than the wild-type strain.	Glucose	19-26	Gpr1p	Saccharomyces cerevisiae S288C	44-48
15743410-6	2005	We also show that GPR1 and GPA2 are required for a rapid increase in cell size in response to glucose.	Glucose	94-101	Gpr1p	Saccharomyces cerevisiae S288C	18-22
15667329-0	2005	Carbon source induced yeast-to-hypha transition in Candida albicans is dependent on the presence of amino acids and on the G-protein-coupled receptor Gpr1.	Carbon	0-6	Gpr1p	Saccharomyces cerevisiae S288C	150-154
15667329-4	2005	Recently we have shown induction of Gpr1 internalization by specific amino acids, e.g. methionine.	Methionine	87-97	Gpr1p	Saccharomyces cerevisiae S288C	36-40
15667330-6	2005	Since inactivation of extracellular glucose sensing through deletion of either the GPR1 or the GPA2 gene causes a marked, but partial, reduction in the ability to modulate cell size and protein content at Start, it is proposed that both extracellular and intracellular glucose signalling is required for properly setting the cell sizer in glucose media.	Glucose	36-43	Gpr1p	Saccharomyces cerevisiae S288C	83-87
15667330-6	2005	Since inactivation of extracellular glucose sensing through deletion of either the GPR1 or the GPA2 gene causes a marked, but partial, reduction in the ability to modulate cell size and protein content at Start, it is proposed that both extracellular and intracellular glucose signalling is required for properly setting the cell sizer in glucose media.	Glucose	269-276	Gpr1p	Saccharomyces cerevisiae S288C	83-87
15667330-6	2005	Since inactivation of extracellular glucose sensing through deletion of either the GPR1 or the GPA2 gene causes a marked, but partial, reduction in the ability to modulate cell size and protein content at Start, it is proposed that both extracellular and intracellular glucose signalling is required for properly setting the cell sizer in glucose media.	Glucose	269-276	Gpr1p	Saccharomyces cerevisiae S288C	83-87
15494315-0	2004	Glucose and sucrose act as agonist and mannose as antagonist ligands of the G protein-coupled receptor Gpr1 in the yeast Saccharomyces cerevisiae.	Glucose	0-7	Gpr1p	Saccharomyces cerevisiae S288C	103-107
15494315-0	2004	Glucose and sucrose act as agonist and mannose as antagonist ligands of the G protein-coupled receptor Gpr1 in the yeast Saccharomyces cerevisiae.	Sucrose	12-19	Gpr1p	Saccharomyces cerevisiae S288C	103-107
15494315-0	2004	Glucose and sucrose act as agonist and mannose as antagonist ligands of the G protein-coupled receptor Gpr1 in the yeast Saccharomyces cerevisiae.	Mannose	39-46	Gpr1p	Saccharomyces cerevisiae S288C	103-107
15494315-3	2004	In the yeast Saccharomyces cerevisiae, rapid activation of the cAMP pathway by glucose and sucrose requires the GPCR Gpr1.	Cyclic AMP	63-67	Gpr1p	Saccharomyces cerevisiae S288C	117-121
15494315-3	2004	In the yeast Saccharomyces cerevisiae, rapid activation of the cAMP pathway by glucose and sucrose requires the GPCR Gpr1.	Glucose	79-86	Gpr1p	Saccharomyces cerevisiae S288C	117-121
15494315-3	2004	In the yeast Saccharomyces cerevisiae, rapid activation of the cAMP pathway by glucose and sucrose requires the GPCR Gpr1.	Sucrose	91-98	Gpr1p	Saccharomyces cerevisiae S288C	117-121
15494315-4	2004	Our results obtained by cysteine scanning mutagenesis and SCAM (substituted cysteine accessibility method) of residues in TMD VI provide strong evidence that glucose and sucrose directly interact as ligands with Gpr1.	Cysteine	24-32	Gpr1p	Saccharomyces cerevisiae S288C	212-216
15494315-4	2004	Our results obtained by cysteine scanning mutagenesis and SCAM (substituted cysteine accessibility method) of residues in TMD VI provide strong evidence that glucose and sucrose directly interact as ligands with Gpr1.	Cysteine	76-84	Gpr1p	Saccharomyces cerevisiae S288C	212-216
15494315-4	2004	Our results obtained by cysteine scanning mutagenesis and SCAM (substituted cysteine accessibility method) of residues in TMD VI provide strong evidence that glucose and sucrose directly interact as ligands with Gpr1.	Glucose	158-165	Gpr1p	Saccharomyces cerevisiae S288C	212-216
15494315-4	2004	Our results obtained by cysteine scanning mutagenesis and SCAM (substituted cysteine accessibility method) of residues in TMD VI provide strong evidence that glucose and sucrose directly interact as ligands with Gpr1.	Sucrose	170-177	Gpr1p	Saccharomyces cerevisiae S288C	212-216
15494315-7	2004	These results support the idea that Gpr1 directly senses sugars and that sugars can effectively bind GPCRs with a low affinity in a binding pocket formed by the transmembrane domains.	Sugars	57-63	Gpr1p	Saccharomyces cerevisiae S288C	36-40
14618376-1	2004	The Saccharomyces cerevisiae phospholipase C Plc1 is involved in cytosolic transient glucose-induced calcium increase, which also requires the Gpr1/Gpa2 receptor/G protein complex and glucose hexokinases.	Glucose	85-92	Gpr1p	Saccharomyces cerevisiae S288C	143-147
14618376-1	2004	The Saccharomyces cerevisiae phospholipase C Plc1 is involved in cytosolic transient glucose-induced calcium increase, which also requires the Gpr1/Gpa2 receptor/G protein complex and glucose hexokinases.	Calcium	101-108	Gpr1p	Saccharomyces cerevisiae S288C	143-147
15667319-5	2005	Glucose and sucrose activate cAMP synthesis through a G-protein-coupled receptor system, consisting of the GPCR Gpr1, the Galpha protein Gpa2 and its RGS protein Rgs2.	Glucose	0-7	Gpr1p	Saccharomyces cerevisiae S288C	112-116
15667319-5	2005	Glucose and sucrose activate cAMP synthesis through a G-protein-coupled receptor system, consisting of the GPCR Gpr1, the Galpha protein Gpa2 and its RGS protein Rgs2.	Sucrose	12-19	Gpr1p	Saccharomyces cerevisiae S288C	112-116
15667319-5	2005	Glucose and sucrose activate cAMP synthesis through a G-protein-coupled receptor system, consisting of the GPCR Gpr1, the Galpha protein Gpa2 and its RGS protein Rgs2.	Cyclic AMP	29-33	Gpr1p	Saccharomyces cerevisiae S288C	112-116
15667319-7	2005	Specific mutations in Gpr1 abolish glucose but not sucrose signalling.	Glucose	35-42	Gpr1p	Saccharomyces cerevisiae S288C	22-26
15714240-3	2004	The protein is 20.9% identical to the Saccharomyces cerevisiae Gpr1p receptor that signals both glucose availability and nitrogen limitation.	Glucose	96-103	Gpr1p	Saccharomyces cerevisiae S288C	63-68
15714240-3	2004	The protein is 20.9% identical to the Saccharomyces cerevisiae Gpr1p receptor that signals both glucose availability and nitrogen limitation.	Nitrogen	121-129	Gpr1p	Saccharomyces cerevisiae S288C	63-68
15339905-2	2004	Glucose activation of cAMP synthesis is thought to be mediated by Gpa2 and its G-protein-coupled receptor Gpr1.	Glucose	0-7	Gpr1p	Saccharomyces cerevisiae S288C	106-110
15339905-2	2004	Glucose activation of cAMP synthesis is thought to be mediated by Gpa2 and its G-protein-coupled receptor Gpr1.	Cyclic AMP	22-26	Gpr1p	Saccharomyces cerevisiae S288C	106-110
15339905-8	2004	Because deletion of GPR1 or GPA2 reduces the glucose-induced cAMP increase the observed enhancement of Ras2 GTP loading is not sufficient for full stimulation of cAMP synthesis.	Glucose	45-52	Gpr1p	Saccharomyces cerevisiae S288C	20-24
15339905-8	2004	Because deletion of GPR1 or GPA2 reduces the glucose-induced cAMP increase the observed enhancement of Ras2 GTP loading is not sufficient for full stimulation of cAMP synthesis.	Cyclic AMP	61-65	Gpr1p	Saccharomyces cerevisiae S288C	20-24
12634328-2	2003	Studies on the GPR1 gene and its encoded protein in the ascomycetous fungus Yarrowia lipolytica have revealed an involvement of this protein in the molecular processes of adaptation to acetic acid.	Acetic Acid	185-196	Gpr1p	Saccharomyces cerevisiae S288C	15-19
12634328-5	2003	Deletion of GPR1 slowed down adaptation to acetic acid, but had no effect on growth in the presence of acetic acid.	Acetic Acid	43-54	Gpr1p	Saccharomyces cerevisiae S288C	12-16
12634328-6	2003	Expression of GPR1 is induced by acetic acid and moderately repressed by glucose.	Acetic Acid	33-44	Gpr1p	Saccharomyces cerevisiae S288C	14-18
12634328-6	2003	Expression of GPR1 is induced by acetic acid and moderately repressed by glucose.	Glucose	73-80	Gpr1p	Saccharomyces cerevisiae S288C	14-18
12634328-9	2003	A model is presented describing a hypothetical function of Gpr1p during adaptation to acetic acid.	Acetic Acid	86-97	Gpr1p	Saccharomyces cerevisiae S288C	59-64
11069660-1	2000	In Saccharomyces cerevisiae, glucose activation of cAMP synthesis requires both the presence of the G-protein-coupled receptor (GPCR) system, Gpr1-Gpa2, and uptake and phosphorylation of the sugar.	Glucose	29-36	Gpr1p	Saccharomyces cerevisiae S288C	142-146
12581367-4	2003	It is dependent on the presence of glucose, which can be detected independently by the G-protein coupled receptor Gpr1 and by the glucose-phosphorylation dependent system.	Glucose	35-42	Gpr1p	Saccharomyces cerevisiae S288C	114-118
12044885-9	2002	The calcium influx induced by addition of high glucose on cells previously stimulated with low glucose levels was inhibited in strains with a deletion in the GPR1 or GPA2 genes, which suggests that glucose would be detected through the Gpr1p/Gpa2p receptor/G protein-coupled (GPCR) complex.	Calcium	4-11	Gpr1p	Saccharomyces cerevisiae S288C	158-162
12044885-9	2002	The calcium influx induced by addition of high glucose on cells previously stimulated with low glucose levels was inhibited in strains with a deletion in the GPR1 or GPA2 genes, which suggests that glucose would be detected through the Gpr1p/Gpa2p receptor/G protein-coupled (GPCR) complex.	Calcium	4-11	Gpr1p	Saccharomyces cerevisiae S288C	236-241
12044885-9	2002	The calcium influx induced by addition of high glucose on cells previously stimulated with low glucose levels was inhibited in strains with a deletion in the GPR1 or GPA2 genes, which suggests that glucose would be detected through the Gpr1p/Gpa2p receptor/G protein-coupled (GPCR) complex.	Glucose	47-54	Gpr1p	Saccharomyces cerevisiae S288C	158-162
12044885-9	2002	The calcium influx induced by addition of high glucose on cells previously stimulated with low glucose levels was inhibited in strains with a deletion in the GPR1 or GPA2 genes, which suggests that glucose would be detected through the Gpr1p/Gpa2p receptor/G protein-coupled (GPCR) complex.	Glucose	47-54	Gpr1p	Saccharomyces cerevisiae S288C	236-241
12044885-9	2002	The calcium influx induced by addition of high glucose on cells previously stimulated with low glucose levels was inhibited in strains with a deletion in the GPR1 or GPA2 genes, which suggests that glucose would be detected through the Gpr1p/Gpa2p receptor/G protein-coupled (GPCR) complex.	Glucose	95-102	Gpr1p	Saccharomyces cerevisiae S288C	236-241
12044885-9	2002	The calcium influx induced by addition of high glucose on cells previously stimulated with low glucose levels was inhibited in strains with a deletion in the GPR1 or GPA2 genes, which suggests that glucose would be detected through the Gpr1p/Gpa2p receptor/G protein-coupled (GPCR) complex.	Glucose	95-102	Gpr1p	Saccharomyces cerevisiae S288C	236-241
12150916-2	2002	The Saccharomyces cerevisiae GPCR Gpr1 senses glucose and controls filamentous growth via an unusual Galpha protein, Gpa2, which lacks any known Gbetagamma subunits.	Glucose	46-53	Gpr1p	Saccharomyces cerevisiae S288C	34-38
11069660-11	2000	Therefore, the low cAMP increases observed with fructose and low glucose in wild-type cells result only from the low sensitivity of the Gpr1-Gpa2 system and not from the intracellular sugar kinase-dependent process.	Fructose	48-56	Gpr1p	Saccharomyces cerevisiae S288C	136-140
11069660-11	2000	Therefore, the low cAMP increases observed with fructose and low glucose in wild-type cells result only from the low sensitivity of the Gpr1-Gpa2 system and not from the intracellular sugar kinase-dependent process.	Glucose	65-72	Gpr1p	Saccharomyces cerevisiae S288C	136-140
11069660-12	2000	In conclusion, we have shown that the two essential requirements for glucose-induced activation of cAMP synthesis can be fulfilled separately: an extracellular glucose detection process dependent on Gpr1 and an intracellular sugar-sensing process requiring the hexose kinases.	Glucose	69-76	Gpr1p	Saccharomyces cerevisiae S288C	199-203
11069660-12	2000	In conclusion, we have shown that the two essential requirements for glucose-induced activation of cAMP synthesis can be fulfilled separately: an extracellular glucose detection process dependent on Gpr1 and an intracellular sugar-sensing process requiring the hexose kinases.	Cyclic AMP	99-103	Gpr1p	Saccharomyces cerevisiae S288C	199-203
11069660-12	2000	In conclusion, we have shown that the two essential requirements for glucose-induced activation of cAMP synthesis can be fulfilled separately: an extracellular glucose detection process dependent on Gpr1 and an intracellular sugar-sensing process requiring the hexose kinases.	Glucose	160-167	Gpr1p	Saccharomyces cerevisiae S288C	199-203
11069660-1	2000	In Saccharomyces cerevisiae, glucose activation of cAMP synthesis requires both the presence of the G-protein-coupled receptor (GPCR) system, Gpr1-Gpa2, and uptake and phosphorylation of the sugar.	Cyclic AMP	51-55	Gpr1p	Saccharomyces cerevisiae S288C	142-146
11069660-9	2000	Gpr1 displayed a very low affinity for glucose (apparent Ka = 75 mM) and responded specifically to extracellular alpha and beta D-glucose and sucrose, but not to fructose, mannose or any glucose analogues tested.	Glucose	39-46	Gpr1p	Saccharomyces cerevisiae S288C	0-4
11069660-9	2000	Gpr1 displayed a very low affinity for glucose (apparent Ka = 75 mM) and responded specifically to extracellular alpha and beta D-glucose and sucrose, but not to fructose, mannose or any glucose analogues tested.	alpha and beta d-glucose	113-137	Gpr1p	Saccharomyces cerevisiae S288C	0-4
11069660-9	2000	Gpr1 displayed a very low affinity for glucose (apparent Ka = 75 mM) and responded specifically to extracellular alpha and beta D-glucose and sucrose, but not to fructose, mannose or any glucose analogues tested.	Sucrose	142-149	Gpr1p	Saccharomyces cerevisiae S288C	0-4
11069660-9	2000	Gpr1 displayed a very low affinity for glucose (apparent Ka = 75 mM) and responded specifically to extracellular alpha and beta D-glucose and sucrose, but not to fructose, mannose or any glucose analogues tested.	Fructose	162-170	Gpr1p	Saccharomyces cerevisiae S288C	0-4
11069660-9	2000	Gpr1 displayed a very low affinity for glucose (apparent Ka = 75 mM) and responded specifically to extracellular alpha and beta D-glucose and sucrose, but not to fructose, mannose or any glucose analogues tested.	Mannose	172-179	Gpr1p	Saccharomyces cerevisiae S288C	0-4
11069660-9	2000	Gpr1 displayed a very low affinity for glucose (apparent Ka = 75 mM) and responded specifically to extracellular alpha and beta D-glucose and sucrose, but not to fructose, mannose or any glucose analogues tested.	Glucose	130-137	Gpr1p	Saccharomyces cerevisiae S288C	0-4
11069660-10	2000	The presence of the constitutively active Gpa2val132 allele in a wild-type strain bypassed the requirement for Gpr1 and increased the low cAMP signal induced by fructose and by low glucose up to the same intensity as the high glucose signal.	Fructose	161-169	Gpr1p	Saccharomyces cerevisiae S288C	111-115
11069660-10	2000	The presence of the constitutively active Gpa2val132 allele in a wild-type strain bypassed the requirement for Gpr1 and increased the low cAMP signal induced by fructose and by low glucose up to the same intensity as the high glucose signal.	Glucose	181-188	Gpr1p	Saccharomyces cerevisiae S288C	111-115
11069660-10	2000	The presence of the constitutively active Gpa2val132 allele in a wild-type strain bypassed the requirement for Gpr1 and increased the low cAMP signal induced by fructose and by low glucose up to the same intensity as the high glucose signal.	Glucose	226-233	Gpr1p	Saccharomyces cerevisiae S288C	111-115
11069660-11	2000	Therefore, the low cAMP increases observed with fructose and low glucose in wild-type cells result only from the low sensitivity of the Gpr1-Gpa2 system and not from the intracellular sugar kinase-dependent process.	Cyclic AMP	19-23	Gpr1p	Saccharomyces cerevisiae S288C	136-140
10655215-5	2000	Epistasis analysis supports a model in which the Gpr1 receptor regulates pseudohyphal growth via the Gpa2p-cAMP-PKA pathway and independently of both the MAP kinase cascade and the PKA related kinase Sch9.	Cyclic AMP	107-111	Gpr1p	Saccharomyces cerevisiae S288C	49-53
10791742-10	2000	GPR1 encodes a member of the G-protein coupled receptor family which acts as a putative glucose receptor for activation of the Ras-cAMP pathway.	Cyclic AMP	131-135	Gpr1p	Saccharomyces cerevisiae S288C	0-4
10655215-6	2000	Genetic and physiological studies indicate that the Gpr1 receptor is activated by glucose and other structurally related sugars.	Glucose	82-89	Gpr1p	Saccharomyces cerevisiae S288C	52-56
10655215-6	2000	Genetic and physiological studies indicate that the Gpr1 receptor is activated by glucose and other structurally related sugars.	Sugars	121-127	Gpr1p	Saccharomyces cerevisiae S288C	52-56
10655215-7	2000	Because expression of the GPR1 gene is known to be induced by nitrogen starvation, the Gpr1 receptor may serve as a dual sensor of abundant carbon source (sugar ligand) and nitrogen starvation.	Nitrogen	62-70	Gpr1p	Saccharomyces cerevisiae S288C	26-30
10655215-7	2000	Because expression of the GPR1 gene is known to be induced by nitrogen starvation, the Gpr1 receptor may serve as a dual sensor of abundant carbon source (sugar ligand) and nitrogen starvation.	Nitrogen	62-70	Gpr1p	Saccharomyces cerevisiae S288C	87-91
10655215-7	2000	Because expression of the GPR1 gene is known to be induced by nitrogen starvation, the Gpr1 receptor may serve as a dual sensor of abundant carbon source (sugar ligand) and nitrogen starvation.	Carbon	140-146	Gpr1p	Saccharomyces cerevisiae S288C	26-30
10655215-7	2000	Because expression of the GPR1 gene is known to be induced by nitrogen starvation, the Gpr1 receptor may serve as a dual sensor of abundant carbon source (sugar ligand) and nitrogen starvation.	Carbon	140-146	Gpr1p	Saccharomyces cerevisiae S288C	87-91
10655215-7	2000	Because expression of the GPR1 gene is known to be induced by nitrogen starvation, the Gpr1 receptor may serve as a dual sensor of abundant carbon source (sugar ligand) and nitrogen starvation.	Sugars	155-160	Gpr1p	Saccharomyces cerevisiae S288C	26-30
10655215-7	2000	Because expression of the GPR1 gene is known to be induced by nitrogen starvation, the Gpr1 receptor may serve as a dual sensor of abundant carbon source (sugar ligand) and nitrogen starvation.	Sugars	155-160	Gpr1p	Saccharomyces cerevisiae S288C	87-91
10655215-7	2000	Because expression of the GPR1 gene is known to be induced by nitrogen starvation, the Gpr1 receptor may serve as a dual sensor of abundant carbon source (sugar ligand) and nitrogen starvation.	Nitrogen	173-181	Gpr1p	Saccharomyces cerevisiae S288C	26-30
10655215-7	2000	Because expression of the GPR1 gene is known to be induced by nitrogen starvation, the Gpr1 receptor may serve as a dual sensor of abundant carbon source (sugar ligand) and nitrogen starvation.	Nitrogen	173-181	Gpr1p	Saccharomyces cerevisiae S288C	87-91
10623592-7	2000	These results indicate that GPR1 regulates both pseudohyphal and invasive growth by a cAMP-dependent mechanism.	Cyclic AMP	86-90	Gpr1p	Saccharomyces cerevisiae S288C	28-32
10572261-0	1999	trans-dominant mutations in the GPR1 gene cause high sensitivity to acetic acid and ethanol in the yeast Yarrowia lipolytica.	Acetic Acid	68-79	Gpr1p	Saccharomyces cerevisiae S288C	32-36
10572261-0	1999	trans-dominant mutations in the GPR1 gene cause high sensitivity to acetic acid and ethanol in the yeast Yarrowia lipolytica.	Ethanol	84-91	Gpr1p	Saccharomyces cerevisiae S288C	32-36
10572261-1	1999	Acetate non-utilizing strains harbouring trans-dominant mutations in the GPR1 gene (GPR1(d)) of the dimorphic yeast Yarrowia lipolytica have been selected and characterized.	Acetates	0-7	Gpr1p	Saccharomyces cerevisiae S288C	73-77
10572261-1	1999	Acetate non-utilizing strains harbouring trans-dominant mutations in the GPR1 gene (GPR1(d)) of the dimorphic yeast Yarrowia lipolytica have been selected and characterized.	Acetates	0-7	Gpr1p	Saccharomyces cerevisiae S288C	84-88
10572261-5	1999	One GPR1(d) mutant has been detected that was highly sensitive to acetic acid but could still grow on ethanol, which indicates putative differences in the function of the GPR1 gene product in the sensitivity to acetic acid and ethanol.	Acetic Acid	66-77	Gpr1p	Saccharomyces cerevisiae S288C	4-8
10572261-5	1999	One GPR1(d) mutant has been detected that was highly sensitive to acetic acid but could still grow on ethanol, which indicates putative differences in the function of the GPR1 gene product in the sensitivity to acetic acid and ethanol.	Ethanol	102-109	Gpr1p	Saccharomyces cerevisiae S288C	4-8
10572261-5	1999	One GPR1(d) mutant has been detected that was highly sensitive to acetic acid but could still grow on ethanol, which indicates putative differences in the function of the GPR1 gene product in the sensitivity to acetic acid and ethanol.	Ethanol	102-109	Gpr1p	Saccharomyces cerevisiae S288C	171-175
10572261-5	1999	One GPR1(d) mutant has been detected that was highly sensitive to acetic acid but could still grow on ethanol, which indicates putative differences in the function of the GPR1 gene product in the sensitivity to acetic acid and ethanol.	Acetic Acid	211-222	Gpr1p	Saccharomyces cerevisiae S288C	4-8
10572261-5	1999	One GPR1(d) mutant has been detected that was highly sensitive to acetic acid but could still grow on ethanol, which indicates putative differences in the function of the GPR1 gene product in the sensitivity to acetic acid and ethanol.	Acetic Acid	211-222	Gpr1p	Saccharomyces cerevisiae S288C	171-175
10572261-5	1999	One GPR1(d) mutant has been detected that was highly sensitive to acetic acid but could still grow on ethanol, which indicates putative differences in the function of the GPR1 gene product in the sensitivity to acetic acid and ethanol.	Ethanol	227-234	Gpr1p	Saccharomyces cerevisiae S288C	4-8
10572261-5	1999	One GPR1(d) mutant has been detected that was highly sensitive to acetic acid but could still grow on ethanol, which indicates putative differences in the function of the GPR1 gene product in the sensitivity to acetic acid and ethanol.	Ethanol	227-234	Gpr1p	Saccharomyces cerevisiae S288C	171-175
10572261-10	1999	Our data suggest that Gpr1p is involved in a general response of cells to the toxic action of dicarbon compounds like acetic acid and ethanol.	dicarbon compounds	94-112	Gpr1p	Saccharomyces cerevisiae S288C	22-27
10572261-10	1999	Our data suggest that Gpr1p is involved in a general response of cells to the toxic action of dicarbon compounds like acetic acid and ethanol.	Acetic Acid	118-129	Gpr1p	Saccharomyces cerevisiae S288C	22-27
10572261-10	1999	Our data suggest that Gpr1p is involved in a general response of cells to the toxic action of dicarbon compounds like acetic acid and ethanol.	Ethanol	134-141	Gpr1p	Saccharomyces cerevisiae S288C	22-27
10476026-4	1999	A G-protein-coupled receptor system (Gpr1-Gpa2) acts upstream of adenylate cyclase and is required for glucose activation of cAMP synthesis in concert with a glucose phosphorylation-dependent mechanism.	Glucose	103-110	Gpr1p	Saccharomyces cerevisiae S288C	37-41
10514491-1	1999	The hormone receptor-like protein Gpr1p physically interacts with phosphatidylinositol-specific phospholipase C (Plc1p) and with the Galpha protein Gpa2p, as shown by two-hybrid assays and co-immune precipitation of epitope-tagged proteins.	Phosphatidylinositols	66-86	Gpr1p	Saccharomyces cerevisiae S288C	34-39
10514491-4	1999	Diploid cells lacking Gpr1p, Plc1p, or Gpa2p fail to form pseudohyphae upon nitrogen depletion, and the filamentation defect of gpr1Delta and plc1Delta strains is rescued by activating a mitogen-activated protein kinase pathway via STE11-4 or by activating a cAMP pathway via overexpressed Tpk2p.	Nitrogen	76-84	Gpr1p	Saccharomyces cerevisiae S288C	22-27
10514491-6	1999	In conclusion, we have identified two physically interacting proteins, Gpr1p and Plc1p, as novel components of a nitrogen signaling pathway controlling the developmental switch from yeast-like to pseudohyphal growth.	Nitrogen	113-121	Gpr1p	Saccharomyces cerevisiae S288C	71-76
10476026-4	1999	A G-protein-coupled receptor system (Gpr1-Gpa2) acts upstream of adenylate cyclase and is required for glucose activation of cAMP synthesis in concert with a glucose phosphorylation-dependent mechanism.	Cyclic AMP	125-129	Gpr1p	Saccharomyces cerevisiae S288C	37-41
10476026-4	1999	A G-protein-coupled receptor system (Gpr1-Gpa2) acts upstream of adenylate cyclase and is required for glucose activation of cAMP synthesis in concert with a glucose phosphorylation-dependent mechanism.	Glucose	158-165	Gpr1p	Saccharomyces cerevisiae S288C	37-41
10373537-3	1999	We show here that the Gpr1-Gpa2-cAMP pathway signals via the cAMP-dependent protein kinase, protein kinase A (PKA), to regulate pseudohyphal differentiation.	Cyclic AMP	32-36	Gpr1p	Saccharomyces cerevisiae S288C	22-26
10373537-3	1999	We show here that the Gpr1-Gpa2-cAMP pathway signals via the cAMP-dependent protein kinase, protein kinase A (PKA), to regulate pseudohyphal differentiation.	Cyclic AMP	61-65	Gpr1p	Saccharomyces cerevisiae S288C	22-26
9388468-1	1997	The Saccharomyces cerevisiae GPR1 (G-protein coupled receptor) gene was isolated using two-hybrid system with a heterotrimeric GTP binding protein alpha subunit Gpa2p as a bait.	Guanosine Triphosphate	127-130	Gpr1p	Saccharomyces cerevisiae S288C	29-33
9813141-0	1998	Gpr1p, a putative G-protein coupled receptor, regulates glucose-dependent cellular cAMP level in yeast Saccharomyces cerevisiae.	Glucose	56-63	Gpr1p	Saccharomyces cerevisiae S288C	0-5
9813141-0	1998	Gpr1p, a putative G-protein coupled receptor, regulates glucose-dependent cellular cAMP level in yeast Saccharomyces cerevisiae.	Cyclic AMP	83-87	Gpr1p	Saccharomyces cerevisiae S288C	0-5
9813141-2	1998	We have found that Gpr1p, a recently identified G-protein (Gpa2p) coupled receptor in yeast Saccharomyces cerevisiae, regulate the cellular cAMP level in response to glucose.	Cyclic AMP	140-144	Gpr1p	Saccharomyces cerevisiae S288C	19-24
9813141-2	1998	We have found that Gpr1p, a recently identified G-protein (Gpa2p) coupled receptor in yeast Saccharomyces cerevisiae, regulate the cellular cAMP level in response to glucose.	Glucose	166-173	Gpr1p	Saccharomyces cerevisiae S288C	19-24
9813141-3	1998	The glucose-induced higher cAMP level found in the strain with GPA2 in multicopy plasmid decreased by deletion of GPR1 gene.	Glucose	4-11	Gpr1p	Saccharomyces cerevisiae S288C	114-118
9813141-3	1998	The glucose-induced higher cAMP level found in the strain with GPA2 in multicopy plasmid decreased by deletion of GPR1 gene.	Cyclic AMP	27-31	Gpr1p	Saccharomyces cerevisiae S288C	114-118
9813141-4	1998	A transient increase of cAMP in response to glucose was not observed in a Deltagpr1 mutant strain and this defect was complemented and restored by introducing GPR1 gene with YCp vector.	Cyclic AMP	24-28	Gpr1p	Saccharomyces cerevisiae S288C	159-163
9813141-4	1998	A transient increase of cAMP in response to glucose was not observed in a Deltagpr1 mutant strain and this defect was complemented and restored by introducing GPR1 gene with YCp vector.	Glucose	44-51	Gpr1p	Saccharomyces cerevisiae S288C	159-163
9813141-5	1998	Gpr1p was also required for the increase of cAMP in response to other fermentable sugars.	Cyclic AMP	44-48	Gpr1p	Saccharomyces cerevisiae S288C	0-5
9813141-5	1998	Gpr1p was also required for the increase of cAMP in response to other fermentable sugars.	Sugars	82-88	Gpr1p	Saccharomyces cerevisiae S288C	0-5
9813141-6	1998	Both membrane proximal regions o the third cytosolic loop in Gpr1p, which has been shown to be important for coupling to G-proteins, were also required for glucose-induced transient increase of cAMP.	Glucose	156-163	Gpr1p	Saccharomyces cerevisiae S288C	61-66
9813141-6	1998	Both membrane proximal regions o the third cytosolic loop in Gpr1p, which has been shown to be important for coupling to G-proteins, were also required for glucose-induced transient increase of cAMP.	Cyclic AMP	194-198	Gpr1p	Saccharomyces cerevisiae S288C	61-66
9813141-7	1998	Our findings suggest that Gpr1p is part of the nutrition sensing machinery most likely acting as a receptor to monitor glucose as well as other fermentable sugars and regulate cellular cAMP levels.	Glucose	119-126	Gpr1p	Saccharomyces cerevisiae S288C	26-31
9813141-7	1998	Our findings suggest that Gpr1p is part of the nutrition sensing machinery most likely acting as a receptor to monitor glucose as well as other fermentable sugars and regulate cellular cAMP levels.	Sugars	156-162	Gpr1p	Saccharomyces cerevisiae S288C	26-31
9813141-7	1998	Our findings suggest that Gpr1p is part of the nutrition sensing machinery most likely acting as a receptor to monitor glucose as well as other fermentable sugars and regulate cellular cAMP levels.	Cyclic AMP	185-189	Gpr1p	Saccharomyces cerevisiae S288C	26-31
10361302-0	1999	A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose.	Glucose	90-97	Gpr1p	Saccharomyces cerevisiae S288C	55-59
10361302-0	1999	A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose.	Cyclic AMP	116-120	Gpr1p	Saccharomyces cerevisiae S288C	55-59
10361302-0	1999	A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose.	Glucose	164-171	Gpr1p	Saccharomyces cerevisiae S288C	55-59
10361302-6	1999	We show that the G-protein coupled receptor (GPCR) Gpr1 interacts with Gpa2 and is required for stimulation of cAMP synthesis by glucose.	Cyclic AMP	111-115	Gpr1p	Saccharomyces cerevisiae S288C	51-55
10361302-6	1999	We show that the G-protein coupled receptor (GPCR) Gpr1 interacts with Gpa2 and is required for stimulation of cAMP synthesis by glucose.	Glucose	129-136	Gpr1p	Saccharomyces cerevisiae S288C	51-55
10361302-9	1999	In addition, we isolated a mutant allele of GPR1, named fil2, in a screen for mutants deficient in glucose-induced loss of heat resistance, which is consistent with its lack of glucose-induced cAMP activation.	Glucose	99-106	Gpr1p	Saccharomyces cerevisiae S288C	44-48
10361302-9	1999	In addition, we isolated a mutant allele of GPR1, named fil2, in a screen for mutants deficient in glucose-induced loss of heat resistance, which is consistent with its lack of glucose-induced cAMP activation.	Glucose	177-184	Gpr1p	Saccharomyces cerevisiae S288C	44-48
10361302-9	1999	In addition, we isolated a mutant allele of GPR1, named fil2, in a screen for mutants deficient in glucose-induced loss of heat resistance, which is consistent with its lack of glucose-induced cAMP activation.	Cyclic AMP	193-197	Gpr1p	Saccharomyces cerevisiae S288C	44-48
10361302-10	1999	Apparently, Gpr1 together with Gpa2 constitute a glucose-sensing system for activation of the cAMP pathway.	Glucose	49-56	Gpr1p	Saccharomyces cerevisiae S288C	12-16
10361302-10	1999	Apparently, Gpr1 together with Gpa2 constitute a glucose-sensing system for activation of the cAMP pathway.	Cyclic AMP	94-98	Gpr1p	Saccharomyces cerevisiae S288C	12-16
10361302-11	1999	Deletion of Gpr1 and/or Gpa2 affected cAPK-controlled features (levels of trehalose, glycogen, heat resistance, expression of STRE-controlled genes and ribosomal protein genes) specifically during the transition to growth on glucose.	Trehalose	74-83	Gpr1p	Saccharomyces cerevisiae S288C	12-16
10361302-11	1999	Deletion of Gpr1 and/or Gpa2 affected cAPK-controlled features (levels of trehalose, glycogen, heat resistance, expression of STRE-controlled genes and ribosomal protein genes) specifically during the transition to growth on glucose.	Glycogen	85-93	Gpr1p	Saccharomyces cerevisiae S288C	12-16
10361302-11	1999	Deletion of Gpr1 and/or Gpa2 affected cAPK-controlled features (levels of trehalose, glycogen, heat resistance, expression of STRE-controlled genes and ribosomal protein genes) specifically during the transition to growth on glucose.	Glucose	225-232	Gpr1p	Saccharomyces cerevisiae S288C	12-16
9524122-9	1998	GPR1 RNA was induced when cells were starved for nitrogen and amino acids.	Nitrogen	49-57	Gpr1p	Saccharomyces cerevisiae S288C	0-4
9524122-10	1998	These results are consistent with a model in which the GPR1/GPA2 pathway activates the Sch9p kinase to generate a response that acts in parallel with that generated by the Ras/cAMP pathway, resulting in the integration of nutrient signals.	Cyclic AMP	176-180	Gpr1p	Saccharomyces cerevisiae S288C	55-59
9388468-2	1997	The GPR1 gene encodes 961 amino acids with predicted seven transmembrane segments and two large cytosolic regions as third cytosolic loop with 350 amino acids where asparagine-rich region was found and the C-terminal region with 283 amino acids.	Asparagine	165-175	Gpr1p	Saccharomyces cerevisiae S288C	4-8
9388468-7	1997	It is likely that a Gpr1p monitors the extracellular signal such as nutrition and transduce it via Gpa2p a possible positive regulator of cAMP level.	Cyclic AMP	138-142	Gpr1p	Saccharomyces cerevisiae S288C	20-25
35194925-7	2022	A subset of those predictions were tested and validated, including the novel targeting of GPR1 signaling by ibuprofen.	Ibuprofen	108-117	Gpr1p	Saccharomyces cerevisiae S288C	90-94
35513769-10	2022	Moreover, mutation of the nutrient sensing receptor gene GPR1 caused the synergistic interaction of CdCl2, but not HgCl2, with AMD to occur at the lowest tested concentrations (1.2 mum).	Cadmium Chloride	100-105	Gpr1p	Saccharomyces cerevisiae S288C	57-61
1349449-9	1992	A new gene (GPR1 = glyoxylate pathway regulation) was detected in which trans-dominant mutations inhibit expression of ACS and the glyoxylate cycle on acetate as carbon source.	glyoxylic acid	19-29	Gpr1p	Saccharomyces cerevisiae S288C	12-16
1349449-9	1992	A new gene (GPR1 = glyoxylate pathway regulation) was detected in which trans-dominant mutations inhibit expression of ACS and the glyoxylate cycle on acetate as carbon source.	glyoxylic acid	131-141	Gpr1p	Saccharomyces cerevisiae S288C	12-16
1349449-9	1992	A new gene (GPR1 = glyoxylate pathway regulation) was detected in which trans-dominant mutations inhibit expression of ACS and the glyoxylate cycle on acetate as carbon source.	Acetates	151-158	Gpr1p	Saccharomyces cerevisiae S288C	12-16
1349449-9	1992	A new gene (GPR1 = glyoxylate pathway regulation) was detected in which trans-dominant mutations inhibit expression of ACS and the glyoxylate cycle on acetate as carbon source.	Carbon	162-168	Gpr1p	Saccharomyces cerevisiae S288C	12-16
33490229-2	2020	Glucose activation of PKA is mediated by G-protein coupled receptor (GPCR) Gpr1, and secondary messenger cAMP.	Glucose	0-7	Gpr1p	Saccharomyces cerevisiae S288C	75-79
30339831-6	2019	Furthermore, we demonstrate that the yeast Gpr1 from Yarrowia lipolytica is an acetate permease, whereas the Ady2 closest homologue in Saccharomyces cerevisiae, Fun34, has no role in acetate uptake.	Acetates	79-86	Gpr1p	Saccharomyces cerevisiae S288C	43-47