PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
28180291-4	2017	The presence of Rev1 inhibited the activity of Polzeta and greatly increased the rate of all three "X-dCTP" mispairs, which Polzeta4 alone made extremely inefficiently.	2'-deoxycytidine 5'-triphosphate	102-106	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	16-20
29042535-0	2017	Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase.	Benzo(a)pyrene	43-57	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	75-79
29042535-2	2017	Rev1 is unique among translesion synthesis DNA polymerases in employing a protein-template-directed mechanism of DNA synthesis opposite undamaged and damaged guanine.	Guanine	158-165	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	0-4
29042535-3	2017	Here we report high-resolution structures of yeast Rev1 with three BP-N 2-dG adducts, namely the 10S (+)-trans-BP-N 2-dG, 10R (+)-cis-BP-N 2-dG, and 10S ( - )-cis-BP-N 2-dG.	bp-n 2-dg	67-76	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	51-55
29042535-3	2017	Here we report high-resolution structures of yeast Rev1 with three BP-N 2-dG adducts, namely the 10S (+)-trans-BP-N 2-dG, 10R (+)-cis-BP-N 2-dG, and 10S ( - )-cis-BP-N 2-dG.	-bp-n 2-dg	110-120	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	51-55
29042535-3	2017	Here we report high-resolution structures of yeast Rev1 with three BP-N 2-dG adducts, namely the 10S (+)-trans-BP-N 2-dG, 10R (+)-cis-BP-N 2-dG, and 10S ( - )-cis-BP-N 2-dG.	cis-bp-n 2-dg	130-143	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	51-55
29042535-3	2017	Here we report high-resolution structures of yeast Rev1 with three BP-N 2-dG adducts, namely the 10S (+)-trans-BP-N 2-dG, 10R (+)-cis-BP-N 2-dG, and 10S ( - )-cis-BP-N 2-dG.	( - )-cis-bp-n 2-dg	153-172	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	51-55
22024240-5	2011	Results with this assay suggest that dCMP is the most frequent dNMP inserted opposite uracil-derived AP sites and demonstrate that dCMP insertion absolutely requires the catalytic activity of Rev1.	Deoxycytidine Monophosphate	37-41	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	192-196
26903512-6	2016	Here we show that the PIP motif of yeast polymerase eta mediates its interactions both with PCNA and with Rev1.	pip	22-25	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	106-110
26903512-7	2016	Moreover, the PIP motif of polymerase eta binds in the hydrophobic pocket on the Rev1 C-terminal domain.	pip	14-17	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	81-85
26903512-8	2016	We also show that the RIR motif of human polymerase kappa and the PIP motif of yeast Msh6 bind both PCNA and Rev1.	pip	66-69	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	109-113
26903512-9	2016	Overall, these findings demonstrate that PIP motifs and RIR motifs have overlapping specificities and can interact with both PCNA and Rev1 in structurally similar ways.	pip	41-44	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	134-138
23240687-7	2013	Here, we report the X-ray crystal structure of the yeast Rev1 BRCT domain and show that substitutions in residues constituting its phosphate-binding pocket do not affect mutagenic TLS.	Phosphates	131-140	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	57-61
23142547-6	2013	Supporting functional significance of this interaction, both the Rev1 pathway and Rad5 are required for translesion synthesis and mutagenesis of 1,N(6)-ethenoadenine.	1,N(6)-ethenoadenine	145-165	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	65-69
22024240-5	2011	Results with this assay suggest that dCMP is the most frequent dNMP inserted opposite uracil-derived AP sites and demonstrate that dCMP insertion absolutely requires the catalytic activity of Rev1.	dnmp	63-67	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	192-196
22024240-5	2011	Results with this assay suggest that dCMP is the most frequent dNMP inserted opposite uracil-derived AP sites and demonstrate that dCMP insertion absolutely requires the catalytic activity of Rev1.	Uracil	86-92	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	192-196
22024240-5	2011	Results with this assay suggest that dCMP is the most frequent dNMP inserted opposite uracil-derived AP sites and demonstrate that dCMP insertion absolutely requires the catalytic activity of Rev1.	Deoxycytidine Monophosphate	131-135	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	192-196
22024240-6	2011	In the complementary nonsense-reversion assay, dCMP insertion likewise depended on the dCMP transferase activity of Rev1.	Deoxycytidine Monophosphate	47-51	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	116-120
22024240-8	2011	These results demonstrate that the catalytic activity of Rev1 is biologically relevant and is required specifically for dCMP insertion during the bypass of endogenous AP sites.	Deoxycytidine Monophosphate	120-124	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	57-61
21975119-5	2011	We characterized the nucleotide incorporation by the catalytically robust fraction of yeast Rev1 and found that it efficiently incorporated dCTP opposite a template abasic site under pre-steady state conditions.	2'-deoxycytidine 5'-triphosphate	140-144	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	92-96
21167175-4	2011	This enzyme inserts a C opposite an abasic lesion with much greater catalytic efficiency than an A, G, or T. We present here the structure of yeast Rev1 in ternary complex with DNA containing an abasic lesion and with dCTP as the incoming nucleotide.	2'-deoxycytidine 5'-triphosphate	218-222	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	148-152
20674515-10	2010	In addition, we show that MMS-treated dot1Delta and rad53-HA cells display increased number of chromosome-associated Rev1 foci.	Methyl Methanesulfonate	26-29	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	117-121
20980236-6	2011	Here, we demonstrate that inactivating Rev1"s DNA polymerase function sensitizes cells to both chronic and acute exposure to 4-nitroquinoline-1-oxide (4-NQO) but not to UV or cisplatin.	4-Nitroquinoline-1-oxide	125-149	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	39-43
20980236-6	2011	Here, we demonstrate that inactivating Rev1"s DNA polymerase function sensitizes cells to both chronic and acute exposure to 4-nitroquinoline-1-oxide (4-NQO) but not to UV or cisplatin.	4-Nitroquinoline-1-oxide	151-156	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	39-43
20980236-7	2011	Full Rev1-dependent resistance to 4-NQO, however, also requires the additional Rev1 functions.	4-Nitroquinoline-1-oxide	34-39	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	5-9
20980236-7	2011	Full Rev1-dependent resistance to 4-NQO, however, also requires the additional Rev1 functions.	4-Nitroquinoline-1-oxide	34-39	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	79-83
20980236-8	2011	When error-free tolerance is disrupted through deletion of MMS2, Rev1"s catalytic activity is more vital for 4-NQO resistance, possibly explaining why the biological significance of Rev1"s catalytic activity has been elusive.	4-Nitroquinoline-1-oxide	109-114	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	65-69
20980236-8	2011	When error-free tolerance is disrupted through deletion of MMS2, Rev1"s catalytic activity is more vital for 4-NQO resistance, possibly explaining why the biological significance of Rev1"s catalytic activity has been elusive.	4-Nitroquinoline-1-oxide	109-114	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	182-186
20980236-11	2011	These results show that Rev1"s catalytic activity is important in vivo when the cell has to cope with specific DNA lesions, such as N(2)-dG.	n(2)-dg	132-139	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	24-28
20388628-7	2010	Therefore, translesion synthesis and mutagenesis of 1,N(6)-ethenoadenine require the catalytic function of the Rev1 dCMP transferase, in contrast to those of UV lesions, which only require the non-catalytic function of Rev1.	1,N(6)-ethenoadenine	52-72	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	111-115
20388628-7	2010	Therefore, translesion synthesis and mutagenesis of 1,N(6)-ethenoadenine require the catalytic function of the Rev1 dCMP transferase, in contrast to those of UV lesions, which only require the non-catalytic function of Rev1.	1,N(6)-ethenoadenine	52-72	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	219-223
19874831-1	2010	We recently demonstrated that Polzeta and Rev1 contribute to alleviate the lethal effects of Me-lex, which selectively generates 3-methyladenine, by error prone lesion bypass.	3-methyladenine	129-144	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	42-46
16783012-4	2006	This substitution appears to abolish all DNA damage-tolerance activities normally carried out by the RAD6/RAD18 pathway, including translesion replication by DNA polymerase zeta/Rev1 and DNA polymerase eta, and the error-free, recombination-dependent component of this pathway, but has little effect on the growth rate, suggesting that G178S may prevent ubiquitination of lysine 164 in PCNA.	Lysine	372-378	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	178-182
18434313-6	2008	Further analyses showed that although yeast Rev1 could incorporate a dCTP opposite the cross-linked guanine, no evidence was found for TLS by pol zeta or a pol zeta/Rev1 combination.	2'-deoxycytidine 5'-triphosphate	69-73	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	44-48
18434313-6	2008	Further analyses showed that although yeast Rev1 could incorporate a dCTP opposite the cross-linked guanine, no evidence was found for TLS by pol zeta or a pol zeta/Rev1 combination.	Guanine	100-107	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	44-48
17960914-2	2007	The X-ray crystal structure of the Rev1p-DNA-dCTP ternary complex showed that Rev1p utilizes an unusual mechanism of nucleotide incorporation whereby the template residue is displaced from the DNA double helix and the side chain of Arg-324 forms hydrogen bonds with the incoming dCTP.	2'-deoxycytidine 5'-triphosphate	45-49	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	35-40
17960914-2	2007	The X-ray crystal structure of the Rev1p-DNA-dCTP ternary complex showed that Rev1p utilizes an unusual mechanism of nucleotide incorporation whereby the template residue is displaced from the DNA double helix and the side chain of Arg-324 forms hydrogen bonds with the incoming dCTP.	2'-deoxycytidine 5'-triphosphate	45-49	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	78-83
17960914-2	2007	The X-ray crystal structure of the Rev1p-DNA-dCTP ternary complex showed that Rev1p utilizes an unusual mechanism of nucleotide incorporation whereby the template residue is displaced from the DNA double helix and the side chain of Arg-324 forms hydrogen bonds with the incoming dCTP.	Arginine	232-235	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	35-40
17960914-2	2007	The X-ray crystal structure of the Rev1p-DNA-dCTP ternary complex showed that Rev1p utilizes an unusual mechanism of nucleotide incorporation whereby the template residue is displaced from the DNA double helix and the side chain of Arg-324 forms hydrogen bonds with the incoming dCTP.	Arginine	232-235	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	78-83
17960914-2	2007	The X-ray crystal structure of the Rev1p-DNA-dCTP ternary complex showed that Rev1p utilizes an unusual mechanism of nucleotide incorporation whereby the template residue is displaced from the DNA double helix and the side chain of Arg-324 forms hydrogen bonds with the incoming dCTP.	Hydrogen	246-254	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	35-40
18824138-1	2009	The Rad6-Rad18 complex mono-ubiquitinates proliferating cell nuclear antigen (PCNA) at the lysine 164 residue after DNA damage and promotes DNA polymerase eta (Poleta)- and Polzeta/Rev1-dependent DNA synthesis.	Lysine	91-97	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	181-185
18824138-4	2009	We have shown that Polzeta and Rev1 localize to HO-induced DSBs in a Mec1-dependent manner and promote Ku-dependent DSB repair.	Holmium	48-50	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	31-35
18824138-5	2009	However, Polzeta and Rev1 localize to DSBs independently of PCNA ubiquitination.	dsbs	38-42	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	21-25
18182332-0	2008	Rev1 and Polzeta influence toxicity and mutagenicity of Me-lex, a sequence selective N3-adenine methylating agent.	n3-adenine	85-95	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	0-4
18275815-3	2008	We show here that yeast Rev1 incorporates the correct nucleotide C opposite a permanently ring-closed form of gamma-HOPdG (PdG) with nearly the same efficiency as opposite an undamaged G. The structural basis of this action lies in the eviction of the PdG adduct from the Rev1 active site, and the pairing of incoming dCTP with a "surrogate" arginine residue.	alpha-hydroxypropanodeoxyguanosine	110-121	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	24-28
18275815-3	2008	We show here that yeast Rev1 incorporates the correct nucleotide C opposite a permanently ring-closed form of gamma-HOPdG (PdG) with nearly the same efficiency as opposite an undamaged G. The structural basis of this action lies in the eviction of the PdG adduct from the Rev1 active site, and the pairing of incoming dCTP with a "surrogate" arginine residue.	alpha-hydroxypropanodeoxyguanosine	110-121	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	272-276
18275815-3	2008	We show here that yeast Rev1 incorporates the correct nucleotide C opposite a permanently ring-closed form of gamma-HOPdG (PdG) with nearly the same efficiency as opposite an undamaged G. The structural basis of this action lies in the eviction of the PdG adduct from the Rev1 active site, and the pairing of incoming dCTP with a "surrogate" arginine residue.	2'-deoxycytidine 5'-triphosphate	318-322	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	24-28
18275815-3	2008	We show here that yeast Rev1 incorporates the correct nucleotide C opposite a permanently ring-closed form of gamma-HOPdG (PdG) with nearly the same efficiency as opposite an undamaged G. The structural basis of this action lies in the eviction of the PdG adduct from the Rev1 active site, and the pairing of incoming dCTP with a "surrogate" arginine residue.	2'-deoxycytidine 5'-triphosphate	318-322	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	272-276
18275815-3	2008	We show here that yeast Rev1 incorporates the correct nucleotide C opposite a permanently ring-closed form of gamma-HOPdG (PdG) with nearly the same efficiency as opposite an undamaged G. The structural basis of this action lies in the eviction of the PdG adduct from the Rev1 active site, and the pairing of incoming dCTP with a "surrogate" arginine residue.	Arginine	342-350	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	24-28
18275815-3	2008	We show here that yeast Rev1 incorporates the correct nucleotide C opposite a permanently ring-closed form of gamma-HOPdG (PdG) with nearly the same efficiency as opposite an undamaged G. The structural basis of this action lies in the eviction of the PdG adduct from the Rev1 active site, and the pairing of incoming dCTP with a "surrogate" arginine residue.	Arginine	342-350	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	272-276
17960914-2	2007	The X-ray crystal structure of the Rev1p-DNA-dCTP ternary complex showed that Rev1p utilizes an unusual mechanism of nucleotide incorporation whereby the template residue is displaced from the DNA double helix and the side chain of Arg-324 forms hydrogen bonds with the incoming dCTP.	Hydrogen	246-254	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	78-83
17960914-2	2007	The X-ray crystal structure of the Rev1p-DNA-dCTP ternary complex showed that Rev1p utilizes an unusual mechanism of nucleotide incorporation whereby the template residue is displaced from the DNA double helix and the side chain of Arg-324 forms hydrogen bonds with the incoming dCTP.	2'-deoxycytidine 5'-triphosphate	279-283	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	35-40
17960914-2	2007	The X-ray crystal structure of the Rev1p-DNA-dCTP ternary complex showed that Rev1p utilizes an unusual mechanism of nucleotide incorporation whereby the template residue is displaced from the DNA double helix and the side chain of Arg-324 forms hydrogen bonds with the incoming dCTP.	2'-deoxycytidine 5'-triphosphate	279-283	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	78-83
17960914-8	2007	Moreover, on the basis of these findings and on structures of the unrelated Escherichia coli MutM DNA glycosylase, we suggest the possible structures for the ternary complexes of Rev1p with the other incoming dNTPs.	Parathion	209-214	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	179-184
16195463-1	2005	The Rev1 DNA polymerase is highly specialized for the incorporation of C opposite template G. We present here the crystal structure of yeast Rev1 bound to template G and incoming 2"-deoxycytidine 5"-triphosphate (dCTP), which reveals that the polymerase itself dictates the identity of the incoming nucleotide, as well as the identity of the templating base.	2'-deoxycytidine 5'-triphosphate	179-211	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	4-8
16546083-3	2006	Rev1 acts as a deoxycytidyl transferase, inserting dCMP opposite lesions.	Deoxycytidine Monophosphate	51-55	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	0-4
16546083-5	2006	Here, we show that budding yeast Polzeta and Rev1 form a complex and associate together with double-strand breaks (DSBs).	dsbs	115-119	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	45-49
16546083-6	2006	As a component of the Polzeta-Rev1 complex, Rev1 plays a noncatalytic role in the association with DSBs.	dsbs	99-103	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	30-34
16415180-0	2006	Poleta, Polzeta and Rev1 together are required for G to T transversion mutations induced by the (+)- and (-)-trans-anti-BPDE-N2-dG DNA adducts in yeast cells.	benzo(a)pyrene 7,8-diol-9,10-epoxide-N2-deoxyguanosine	120-130	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	20-24
16415180-10	2006	These results show that while the Polzeta pathway is generally required for translesion synthesis and mutagenesis of the (+)- and (-)-trans-anti-BPDE-N2-dG DNA adducts, Poleta, Polzeta and Rev1 together are required for G-->T transversion mutations, a major type of mutagenesis induced by these lesions.	polzeta	34-41	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	189-193
16415180-10	2006	These results show that while the Polzeta pathway is generally required for translesion synthesis and mutagenesis of the (+)- and (-)-trans-anti-BPDE-N2-dG DNA adducts, Poleta, Polzeta and Rev1 together are required for G-->T transversion mutations, a major type of mutagenesis induced by these lesions.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	145-149	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	189-193
16415180-10	2006	These results show that while the Polzeta pathway is generally required for translesion synthesis and mutagenesis of the (+)- and (-)-trans-anti-BPDE-N2-dG DNA adducts, Poleta, Polzeta and Rev1 together are required for G-->T transversion mutations, a major type of mutagenesis induced by these lesions.	Nitrogen	150-152	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	189-193
16314579-8	2005	These results support a major role for Rev1-dependent dCMP insertion across from AP sites and a lesser role for dAMP insertion.	Deoxycytidine Monophosphate	54-58	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	39-43
16546083-6	2006	As a component of the Polzeta-Rev1 complex, Rev1 plays a noncatalytic role in the association with DSBs.	dsbs	99-103	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	44-48
16546083-8	2006	We further show that Mec1-dependent phosphorylation promotes the Polzeta-Rev1 association with DSBs.	dsbs	95-99	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	73-77
16546083-9	2006	Rev1 association with DSBs requires neither the function of the Rad24 checkpoint-clamp loader nor the Rad6-Rad18-mediated ubiquitination of PCNA.	dsbs	22-26	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	0-4
16195463-1	2005	The Rev1 DNA polymerase is highly specialized for the incorporation of C opposite template G. We present here the crystal structure of yeast Rev1 bound to template G and incoming 2"-deoxycytidine 5"-triphosphate (dCTP), which reveals that the polymerase itself dictates the identity of the incoming nucleotide, as well as the identity of the templating base.	2'-deoxycytidine 5'-triphosphate	179-211	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	141-145
16195463-1	2005	The Rev1 DNA polymerase is highly specialized for the incorporation of C opposite template G. We present here the crystal structure of yeast Rev1 bound to template G and incoming 2"-deoxycytidine 5"-triphosphate (dCTP), which reveals that the polymerase itself dictates the identity of the incoming nucleotide, as well as the identity of the templating base.	2'-deoxycytidine 5'-triphosphate	213-217	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	4-8
16195463-1	2005	The Rev1 DNA polymerase is highly specialized for the incorporation of C opposite template G. We present here the crystal structure of yeast Rev1 bound to template G and incoming 2"-deoxycytidine 5"-triphosphate (dCTP), which reveals that the polymerase itself dictates the identity of the incoming nucleotide, as well as the identity of the templating base.	2'-deoxycytidine 5'-triphosphate	213-217	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	141-145
16195463-3	2005	Instead, the template G is evicted from the DNA helix, and it makes optimal hydrogen bonds with a segment of Rev1.	Hydrogen	76-84	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	109-113
15282292-0	2004	Efficient and error-free replication past a minor-groove N2-guanine adduct by the sequential action of yeast Rev1 and DNA polymerase zeta.	Guanine	60-67	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	109-113
15282292-7	2004	Based upon these observations, we suggest that an important role of the Rev1 DNA synthetic activity in lesion bypass is to incorporate a C opposite the various N(2)-guanine DNA minor-groove adducts that form in DNA.	n(2)-guanine	160-172	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	72-76
15284331-10	2004	Consistent with these conclusions, rad30 mutant cells were sensitive to methyl methanesulfonate (MMS), and rev1 rad30 or rev3 rad30 double mutant cells were synergistically more sensitive to MMS than the respective single mutant strains.	Methyl Methanesulfonate	191-194	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	107-111
14960722-0	2004	Translesion synthesis of acetylaminofluorene-dG adducts by DNA polymerase zeta is stimulated by yeast Rev1 protein.	2-Acetylaminofluorene	25-44	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	102-106
14960722-5	2004	We have analyzed the role of Rev1 in translesion synthesis of an acetylaminofluorene (AAF)-dG DNA adduct.	N-(deoxyguanosin-8-yl)acetylaminofluorene	65-93	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	29-33
14960722-6	2004	Purified yeast Rev1 was essentially unresponsive to a template AAF-dG DNA adduct, in contrast to its efficient C insertion opposite a template 1,N6-ethenoadenine adduct.	1,N(6)-ethenoadenine	143-161	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	15-19
11850424-4	2002	We show that Rev1 specifically inserts a C residue opposite template G, and it is approximately 25-, 40-, and 400-fold less efficient at inserting a C residue opposite an abasic site, an O(6)-methylguanine, and an 8-oxoguanine lesion, respectively.	O-(6)-methylguanine	187-205	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	13-17
12466536-4	2002	Deletion of REV1 decreased the transformation efficiency and the incorporation of cytosine nearly to a background level.	Cytosine	82-90	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	12-16
12466536-9	2002	However, deletion of REV1 decreased the transformation efficiency with F-containing oligonucleotide as in the case of O.	Oligonucleotides	84-99	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	21-25
11850424-4	2002	We show that Rev1 specifically inserts a C residue opposite template G, and it is approximately 25-, 40-, and 400-fold less efficient at inserting a C residue opposite an abasic site, an O(6)-methylguanine, and an 8-oxoguanine lesion, respectively.	8-hydroxyguanine	214-226	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	13-17
34454693-7	2021	The data indicated that yeast strains deficient in BER (Ogg1p), NER (complex Rad1p-Rad10p) or TLS (Rev1p, Rev3p and Rad30p) proteins are associated with increased sensitivity to sodium valproate.	Valproic Acid	178-194	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	99-104
12903118-2	2002	We introduced oligonucleotide containing a natural abasic site and a tetrahydrofuran abasic site into Rev1 mutants, rev1AA, which contains mutations of Asp467 and Glu468 residues of Rev1p to Ala in order to inactivate dCMP transferase activity, and rev1 delta, which lacks its whole coding sequence.	Oligonucleotides	14-29	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	182-187
12903118-2	2002	We introduced oligonucleotide containing a natural abasic site and a tetrahydrofuran abasic site into Rev1 mutants, rev1AA, which contains mutations of Asp467 and Glu468 residues of Rev1p to Ala in order to inactivate dCMP transferase activity, and rev1 delta, which lacks its whole coding sequence.	Oligonucleotides	14-29	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	116-120
12903118-2	2002	We introduced oligonucleotide containing a natural abasic site and a tetrahydrofuran abasic site into Rev1 mutants, rev1AA, which contains mutations of Asp467 and Glu468 residues of Rev1p to Ala in order to inactivate dCMP transferase activity, and rev1 delta, which lacks its whole coding sequence.	tetrahydrofuran	69-84	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	102-106
12903118-2	2002	We introduced oligonucleotide containing a natural abasic site and a tetrahydrofuran abasic site into Rev1 mutants, rev1AA, which contains mutations of Asp467 and Glu468 residues of Rev1p to Ala in order to inactivate dCMP transferase activity, and rev1 delta, which lacks its whole coding sequence.	tetrahydrofuran	69-84	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	116-120
12903118-2	2002	We introduced oligonucleotide containing a natural abasic site and a tetrahydrofuran abasic site into Rev1 mutants, rev1AA, which contains mutations of Asp467 and Glu468 residues of Rev1p to Ala in order to inactivate dCMP transferase activity, and rev1 delta, which lacks its whole coding sequence.	Alanine	191-194	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	182-187
12903118-2	2002	We introduced oligonucleotide containing a natural abasic site and a tetrahydrofuran abasic site into Rev1 mutants, rev1AA, which contains mutations of Asp467 and Glu468 residues of Rev1p to Ala in order to inactivate dCMP transferase activity, and rev1 delta, which lacks its whole coding sequence.	Alanine	191-194	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	116-120
12903118-3	2002	The transformation efficiencies of rev1AA with abasic-containing oligonucleotides were lower than those of B7528, a strain proficient in REV1 gene, but much higher than rev1 delta mutant.	Oligonucleotides	65-81	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	35-39
34851089-5	2021	Rev1 is the main TLS polymerase for specifically incorporating Cs on the opposite position of AP sites to cause the dominant C-to-G conversion, while Poldelta incorporates Ts or As on the opposite of AP sites, resulting in C-to-A and C-to-T conversions.	Cesium	63-65	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	0-4
10931348-2	2000	We showed previously that Rev1p possesses a deoxycytidyl transferase activity, which incorporates dCMP opposite abasic sites in the DNA template, and that dCMP insertion is the major event during bypass of an abasic site in vivo.	Deoxycytidine Monophosphate	98-102	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	26-31
10931348-2	2000	We showed previously that Rev1p possesses a deoxycytidyl transferase activity, which incorporates dCMP opposite abasic sites in the DNA template, and that dCMP insertion is the major event during bypass of an abasic site in vivo.	Deoxycytidine Monophosphate	155-159	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	26-31
10931348-3	2000	However, we now find that Rev1p function is needed for the bypass of a T-T (6-4) UV photoproduct, a process in which dCMP incorporation occurs only very rarely, indicating that Rev1p possesses a second function.	Deoxycytidine Monophosphate	117-121	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	26-31
9765213-5	1998	The apn1Delta apn2Delta strain displays a highly elevated level of MMS-induced mutagenesis, which is dependent on the REV3, REV7, and REV1 genes.	Methyl Methanesulfonate	67-70	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	134-138
8751446-4	1996	We show here that Rev1 protein has a deoxycytidyl transferase activity which transfers a dCMP residue from dCTP to the 3" end of a DNA primer in a template-dependent reaction.	Deoxycytidine Monophosphate	89-93	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	18-22
8751446-4	1996	We show here that Rev1 protein has a deoxycytidyl transferase activity which transfers a dCMP residue from dCTP to the 3" end of a DNA primer in a template-dependent reaction.	2'-deoxycytidine 5'-triphosphate	107-111	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	18-22
8977026-5	1996	Rev1 protein is a terminal nucleotidyl transferase that inserts dCMP opposite template G, A and abasic sites.	Deoxycytidine Monophosphate	64-68	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	0-4
32633759-5	2020	A dCMP residue was faithfully inserted across the ICL-G by Pol eta, Pol zeta, and Rev1-Pol zeta.	Deoxycytidine Monophosphate	2-6	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	82-86
32999062-3	2020	Rev1 is a specialized TLS polymerase that bypasses abasic sites, as well as minor-groove and exocyclic guanine adducts.	Guanine	103-110	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	0-4
32999062-4	2020	Lesion bypass is accomplished using a unique protein-template mechanism in which the templating base is evicted from the DNA helix and the incoming dCTP hydrogen bonds with an arginine side chain of Rev1.	2'-deoxycytidine 5'-triphosphate	148-152	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	199-203
32999062-4	2020	Lesion bypass is accomplished using a unique protein-template mechanism in which the templating base is evicted from the DNA helix and the incoming dCTP hydrogen bonds with an arginine side chain of Rev1.	Hydrogen	153-161	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	199-203
32999062-4	2020	Lesion bypass is accomplished using a unique protein-template mechanism in which the templating base is evicted from the DNA helix and the incoming dCTP hydrogen bonds with an arginine side chain of Rev1.	Arginine	176-184	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	199-203
32999062-8	2020	Moreover, we found that following nucleotide incorporation, Rev1 converts the pyrophosphate product to two monophosphates, which drives the reaction in the forward direction and prevents pyrophosphorolysis.	diphosphoric acid	78-91	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	60-64
32999062-8	2020	Moreover, we found that following nucleotide incorporation, Rev1 converts the pyrophosphate product to two monophosphates, which drives the reaction in the forward direction and prevents pyrophosphorolysis.	monophosphates	107-121	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	60-64
32005731-3	2020	Under 2 mM H2O2 treatment, the deletion of REV1 resulted in a 1.5- and 2.8-fold decrease in the survival rate and mutation frequency, respectively, whereas overexpression of REV1 increased the survival rate and mutation frequency by 1.1- and 2.9-fold, respectively, as compared to the survival rate and mutation frequency of the wild-type strain.	Water	11-15	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	43-47
32005731-3	2020	Under 2 mM H2O2 treatment, the deletion of REV1 resulted in a 1.5- and 2.8-fold decrease in the survival rate and mutation frequency, respectively, whereas overexpression of REV1 increased the survival rate and mutation frequency by 1.1- and 2.9-fold, respectively, as compared to the survival rate and mutation frequency of the wild-type strain.	Water	11-15	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	174-178
32005731-7	2020	Overall, these findings demonstrate that Sml1 could be a novel regulator that mediates Rev1 dephosphorylation to inhibit its activity during oxidative stress.IMPORTANCE Rev1 was critical for cell growth in S. cerevisiae, and the deletion of REV1 caused a severe growth defect under exposure to oxidative stress with 2 mM H2O2 Furthermore, we found that Sml1 physically interacted with Rev1 and inhibited Rev1 phosphorylation, thereby inhibited Rev1 DNA antioxidant activity.	Water	321-325	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	87-91
32005731-7	2020	Overall, these findings demonstrate that Sml1 could be a novel regulator that mediates Rev1 dephosphorylation to inhibit its activity during oxidative stress.IMPORTANCE Rev1 was critical for cell growth in S. cerevisiae, and the deletion of REV1 caused a severe growth defect under exposure to oxidative stress with 2 mM H2O2 Furthermore, we found that Sml1 physically interacted with Rev1 and inhibited Rev1 phosphorylation, thereby inhibited Rev1 DNA antioxidant activity.	Water	321-325	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	169-173
32005731-7	2020	Overall, these findings demonstrate that Sml1 could be a novel regulator that mediates Rev1 dephosphorylation to inhibit its activity during oxidative stress.IMPORTANCE Rev1 was critical for cell growth in S. cerevisiae, and the deletion of REV1 caused a severe growth defect under exposure to oxidative stress with 2 mM H2O2 Furthermore, we found that Sml1 physically interacted with Rev1 and inhibited Rev1 phosphorylation, thereby inhibited Rev1 DNA antioxidant activity.	Water	321-325	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	169-173
32005731-7	2020	Overall, these findings demonstrate that Sml1 could be a novel regulator that mediates Rev1 dephosphorylation to inhibit its activity during oxidative stress.IMPORTANCE Rev1 was critical for cell growth in S. cerevisiae, and the deletion of REV1 caused a severe growth defect under exposure to oxidative stress with 2 mM H2O2 Furthermore, we found that Sml1 physically interacted with Rev1 and inhibited Rev1 phosphorylation, thereby inhibited Rev1 DNA antioxidant activity.	Water	321-325	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	169-173
32005731-7	2020	Overall, these findings demonstrate that Sml1 could be a novel regulator that mediates Rev1 dephosphorylation to inhibit its activity during oxidative stress.IMPORTANCE Rev1 was critical for cell growth in S. cerevisiae, and the deletion of REV1 caused a severe growth defect under exposure to oxidative stress with 2 mM H2O2 Furthermore, we found that Sml1 physically interacted with Rev1 and inhibited Rev1 phosphorylation, thereby inhibited Rev1 DNA antioxidant activity.	Water	321-325	deoxycytidyl transferase	Saccharomyces cerevisiae S288C	169-173