PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
34416429-9	2022	To destabilize mutant p53, we targeted RNF128 Iso1 either by mutating asparagine (N48, 59 and 101) residues to block glycosylation to facilitate beta-TrCP1-mediated degradation or by mutating proline (P54 and 105) residues to restore p53 polyubiquitinating ability.	Asparagine	70-80	tripartite motif containing 31	Homo sapiens	39-50
12170760-6	2002	Only one of 13 strongly induced genes (ring finger protein TRIM31) contains a putative retinoid response element in its promoter; TRIM31 also shows the most rapid kinetics of induction by retinoids.	Retinoids	87-95	tripartite motif containing 31	Homo sapiens	59-65
12170760-6	2002	Only one of 13 strongly induced genes (ring finger protein TRIM31) contains a putative retinoid response element in its promoter; TRIM31 also shows the most rapid kinetics of induction by retinoids.	Retinoids	87-95	tripartite motif containing 31	Homo sapiens	130-136
12170760-6	2002	Only one of 13 strongly induced genes (ring finger protein TRIM31) contains a putative retinoid response element in its promoter; TRIM31 also shows the most rapid kinetics of induction by retinoids.	Retinoids	188-197	tripartite motif containing 31	Homo sapiens	59-65
12170760-6	2002	Only one of 13 strongly induced genes (ring finger protein TRIM31) contains a putative retinoid response element in its promoter; TRIM31 also shows the most rapid kinetics of induction by retinoids.	Retinoids	188-197	tripartite motif containing 31	Homo sapiens	130-136
9560429-0	1998	The rnf gene products in rhodobacter capsulatus play an essential role in nitrogen fixation during anaerobic DMSO-dependent growth in the dark The rnf genes in Rhodobacter capsulatus are essential for nitrogen fixation in the light.	Nitrogen	74-82	tripartite motif containing 31	Homo sapiens	4-7
9560429-0	1998	The rnf gene products in rhodobacter capsulatus play an essential role in nitrogen fixation during anaerobic DMSO-dependent growth in the dark The rnf genes in Rhodobacter capsulatus are essential for nitrogen fixation in the light.	Nitrogen	74-82	tripartite motif containing 31	Homo sapiens	5-8
9560429-0	1998	The rnf gene products in rhodobacter capsulatus play an essential role in nitrogen fixation during anaerobic DMSO-dependent growth in the dark The rnf genes in Rhodobacter capsulatus are essential for nitrogen fixation in the light.	Dimethyl Sulfoxide	109-113	tripartite motif containing 31	Homo sapiens	4-7
9560429-0	1998	The rnf gene products in rhodobacter capsulatus play an essential role in nitrogen fixation during anaerobic DMSO-dependent growth in the dark The rnf genes in Rhodobacter capsulatus are essential for nitrogen fixation in the light.	Dimethyl Sulfoxide	109-113	tripartite motif containing 31	Homo sapiens	5-8
9560429-0	1998	The rnf gene products in rhodobacter capsulatus play an essential role in nitrogen fixation during anaerobic DMSO-dependent growth in the dark The rnf genes in Rhodobacter capsulatus are essential for nitrogen fixation in the light.	Nitrogen	75-83	tripartite motif containing 31	Homo sapiens	4-7
9560429-0	1998	The rnf gene products in rhodobacter capsulatus play an essential role in nitrogen fixation during anaerobic DMSO-dependent growth in the dark The rnf genes in Rhodobacter capsulatus are essential for nitrogen fixation in the light.	Nitrogen	75-83	tripartite motif containing 31	Homo sapiens	5-8
9560429-4	1998	These results indicate that rnf gene products play an essential role in nitrogen fixation without any functional link to the cyclic electron transport system.	Nitrogen	73-81	tripartite motif containing 31	Homo sapiens	29-32
34105476-11	2021	Intervention of LY294002 significantly enhanced the inhibition on cell proliferation and the promotion on apoptosis mediated by TRIM31 gene silencing in U266 cells.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	16-24	tripartite motif containing 31	Homo sapiens	128-134
34171297-3	2021	Protein arginine methyltransferase 7 (PRMT7) forms aggregates to catalyze MAVS monomethylation at arginine residue 52 (R52), attenuating its binding to TRIM31 and RIG-I, which leads to the suppression of MAVS aggregation and subsequent activation.	Arginine	98-106	tripartite motif containing 31	Homo sapiens	152-158
34218200-3	2021	Here we demonstrated that TRIM31 was significantly downregulated in the ischemic brain and the deficiency of TRIM31 alleviated brain injury induced by middle cerebral artery occlusion by reducing reactive oxygen species production and maintaining mitochondrial homeostasis.	oxygen species	205-219	tripartite motif containing 31	Homo sapiens	26-32
34218200-4	2021	Mechanistically, we found that TRIM31 is an E3 ubiquitin ligase for TP53-induced glycolysis and apoptosis regulator (TIGAR), which confers protection against brain ischemia by increasing the pentose phosphate pathway flux and preserving mitochondria function.	Pentosephosphates	191-208	tripartite motif containing 31	Homo sapiens	31-37
32929041-6	2020	This phosphorylation event also stabilizes NLRP3 by reducing its ubiquitination on lysine 496, which inhibits its proteasome-mediated degradation by the E3 ligase Trim31.	Lysine	83-89	tripartite motif containing 31	Homo sapiens	163-169
32232394-0	2020	TRIM31 promotes acute myeloid leukemia progression and sensitivity to daunorubicin through the Wnt/beta-catenin signaling.	Daunorubicin	70-82	tripartite motif containing 31	Homo sapiens	0-6
32323100-8	2020	We found that co-treatment with LPS and ATP increased the secretion of IL-1beta and expression of NLRP3 in HPDLFs, while TRIM31 overexpression could reverse these effects caused by LPS and ATP.	Adenosine Triphosphate	189-192	tripartite motif containing 31	Homo sapiens	121-127
32323100-10	2020	TRIM31 may alleviate IL-1ss secretion caused by LPS and ATP via promoting the ubiquitination of NLRP3 and may exert an influence on the development of AP.	Adenosine Triphosphate	56-59	tripartite motif containing 31	Homo sapiens	0-6
32765650-4	2020	Overexpression of TRIM31 increased cell viability, increased TMZ IC50 values and inhibited apoptosis in A172 and U251 cells; whereas overexpression of TRIM31 decreased the expression of the apoptosis-associated protein p53.	Temozolomide	61-64	tripartite motif containing 31	Homo sapiens	18-24
32765650-5	2020	Knockdown of TRIM31 increased apoptosis in cells treated with TMZ.	Temozolomide	62-65	tripartite motif containing 31	Homo sapiens	13-19
32765650-6	2020	Additionally, the mechanisms by which TRIM31 affected glioma cells treated with TMZ were determined.	Temozolomide	80-83	tripartite motif containing 31	Homo sapiens	38-44
32765650-7	2020	Overexpression of TRIM31 increased phosphorylation of AKT and inhibiting the PI3K/AKT signaling pathway abolished the increase in cell viability and decreased phospho-Akt protein expression in TRIM31 overexpressing A172 cells treated with TMZ.	Temozolomide	239-242	tripartite motif containing 31	Homo sapiens	18-24
32232394-10	2020	The IC50 of daunorubicin was significantly decreased in si-TRIM31 transfected cells.	Daunorubicin	12-24	tripartite motif containing 31	Homo sapiens	59-65
32232394-13	2020	Activation of Wnt/beta-catenin pathway by LiCl abolished the effects of si-TRIM31 on cell proliferation, apoptosis and sensitivity to daunorubicin in AML cells.	Lithium Chloride	42-46	tripartite motif containing 31	Homo sapiens	75-81
32232394-13	2020	Activation of Wnt/beta-catenin pathway by LiCl abolished the effects of si-TRIM31 on cell proliferation, apoptosis and sensitivity to daunorubicin in AML cells.	Daunorubicin	134-146	tripartite motif containing 31	Homo sapiens	75-81
32232394-14	2020	In conclusion, TRIM31 promoted leukemogenesis and chemoresistance to daunorubicin in AML.	Daunorubicin	69-81	tripartite motif containing 31	Homo sapiens	15-21
27216961-4	2016	Here, we report that human TRIM31 (tripartite motif), an intestine-specific protein localized in mitochondria, is essential for promoting lipopolysaccharide-induced Atg5/Atg7-independent autophagy.	tripartite	35-45	tripartite motif containing 31	Homo sapiens	27-33
29930725-0	2018	Oncogenic TRIM31 confers gemcitabine resistance in pancreatic cancer via activating the NF-kappaB signaling pathway.	gemcitabine	25-36	tripartite motif containing 31	Homo sapiens	10-16
29930725-8	2018	TRIM31 overexpression confers gemcitabine resistance on pancreatic cancer cells; however, inhibition of TRIM31 sensitized pancreatic cancer cell lines to gemcitabine cytotoxicity both in vitro and in vivo.	gemcitabine	30-41	tripartite motif containing 31	Homo sapiens	0-6
29930725-8	2018	TRIM31 overexpression confers gemcitabine resistance on pancreatic cancer cells; however, inhibition of TRIM31 sensitized pancreatic cancer cell lines to gemcitabine cytotoxicity both in vitro and in vivo.	gemcitabine	154-165	tripartite motif containing 31	Homo sapiens	104-110
29736218-1	2018	Tripartite motif 31(TRIM31) is a new member of the E3 ubiquitin ligase family, which plays a role in many biological processes.	tripartite	0-10	tripartite motif containing 31	Homo sapiens	20-26
27929086-7	2016	Furthermore, TRIM31 deficiency attenuates the severity of dextran sodium sulfate (DSS)-induced colitis, an inflammatory bowel diseases model in which NLRP3 possesses protective roles.	dextran sodium sulfate	58-80	tripartite motif containing 31	Homo sapiens	13-19
27929086-7	2016	Furthermore, TRIM31 deficiency attenuates the severity of dextran sodium sulfate (DSS)-induced colitis, an inflammatory bowel diseases model in which NLRP3 possesses protective roles.	dss	82-85	tripartite motif containing 31	Homo sapiens	13-19
29930725-11	2018	Targeting TRIM31 signaling may be a promising strategy to enhance gemcitabine response during pancreatic cancer chemo-resistance.	gemcitabine	66-77	tripartite motif containing 31	Homo sapiens	10-16
27216961-5	2016	TRIM31 directly interacts with phosphatidylethanolamine in a palmitoylation-dependent manner, leading to induction of autolysosome formation.	phosphatidylethanolamine	31-55	tripartite motif containing 31	Homo sapiens	0-6
21231912-2	2011	One of the family proteins, TRIM31, was originally identified as a gene induced by growth-suppressive retinoid.	Retinoids	102-110	tripartite motif containing 31	Homo sapiens	28-34
22589545-2	2012	The human RING finger (RNF) E3 ubiquitin ligases, RNF8 and RNF168, with the E2 ubiquitin-conjugating complex Ubc13/Mms2, perform the majority of Lys-63 ubiquitylation in homologous recombination.	Lysine	145-148	tripartite motif containing 31	Homo sapiens	10-21
22589545-2	2012	The human RING finger (RNF) E3 ubiquitin ligases, RNF8 and RNF168, with the E2 ubiquitin-conjugating complex Ubc13/Mms2, perform the majority of Lys-63 ubiquitylation in homologous recombination.	Lysine	145-148	tripartite motif containing 31	Homo sapiens	23-26
17692727-15	2007	Overall, the majority (96.9%) of AEs in the RNF study were mild (69.5%) or moderate (27.5%) in severity.	aes	33-36	tripartite motif containing 31	Homo sapiens	44-47
17692727-17	2007	The proportions of NAb+ patients with high NAb titers (>1000 NU/mL) at week 48 were 11.1% in the RNF study and 19.5% in the EVIDENCE study.	nab	19-22	tripartite motif containing 31	Homo sapiens	100-103