PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 35361747-4 2022 RBM4-S functions as a tumor promoter by abolishing RBM4-FL-mediated inhibition of the activity of the SRSF1-mTORC1 signaling pathway. Fluorides 56-58 RNA binding motif protein 4 Homo sapiens 0-4 35361747-4 2022 RBM4-S functions as a tumor promoter by abolishing RBM4-FL-mediated inhibition of the activity of the SRSF1-mTORC1 signaling pathway. Fluorides 56-58 RNA binding motif protein 4 Homo sapiens 51-55 25414336-1 2014 Mammalian splicing regulatory protein RNA-binding motif protein 4 (RBM4) has an alanine repeat-containing C-terminal domain (CAD) that confers both nuclear- and splicing speckle-targeting activities. Alanine 80-87 RNA binding motif protein 4 Homo sapiens 38-65 35200043-3 2022 The aim of this research was to examine the reach of Lark"s DPP, a fully digital artificial-intelligence-powered DPP. dpp 60-63 RNA binding motif protein 4 Homo sapiens 53-57 35200043-3 2022 The aim of this research was to examine the reach of Lark"s DPP, a fully digital artificial-intelligence-powered DPP. dpp 113-116 RNA binding motif protein 4 Homo sapiens 53-57 35200043-5 2022 Examination of the Lark DPP sample revealed that 24.4% of members lived in rural areas, 30.8% lived in whole county health professional shortage areas, and only 7.6% of members lived in a zip code with an in-person DPP. dpp 24-27 RNA binding motif protein 4 Homo sapiens 19-23 35200043-6 2022 When comparing the Lark sample with the NDPP and NHIS samples, Lark DPP enrollees tended to be younger and have a higher body mass index (BMI) (p"s < 0.001). dpp 68-71 RNA binding motif protein 4 Homo sapiens 63-67 35200043-7 2022 Lark provides convenient access to a DPP for individuals living in hard-to-reach areas who may face barriers to participating in in-person or telephonic DPPs or who prefer a digital program. dpp 37-40 RNA binding motif protein 4 Homo sapiens 0-4 33020268-8 2020 We used photoactivatable ribonucleoside-enhanced cross-linking and immunoprecipitation to demonstrate that RBM4 indeed bound ERV transcripts at CGG consensus elements. Ribonucleosides 25-39 RNA binding motif protein 4 Homo sapiens 107-111 25414336-11 2014 Our results indicate that the alanine-rich CAD, in conjunction with its conjoined RNA-binding domain(s), differentially influences the subnuclear localization and biogenesis of RBM4 and CoAZ. Alanine 30-37 RNA binding motif protein 4 Homo sapiens 177-181 30056345-11 2018 Significant positive correlation (r > 0.76) was observed between 25n-alkanes and 30PAHs at Kharg and Lark sediments with TOC content, especially for the sites with high total pollutant concentrations. 25n-alkanes 69-80 RNA binding motif protein 4 Homo sapiens 106-110 30056345-11 2018 Significant positive correlation (r > 0.76) was observed between 25n-alkanes and 30PAHs at Kharg and Lark sediments with TOC content, especially for the sites with high total pollutant concentrations. 2,6-diamino-2,3,6-trideoxy-alpha-D-glucose(2+) 126-129 RNA binding motif protein 4 Homo sapiens 106-110 30327195-4 2018 Overexpression of RBM4a enhanced the relative levels of PRDM16-ex 16 transcripts by simultaneously interacting with exonic and intronic CU elements, which encoded the PRDM16S isoform containing a distinct C-terminus. Copper 136-138 RNA binding motif protein 4 Homo sapiens 18-23 28216134-11 2017 Some sampling sites especially Kharg, Lavan, Siri and Lark indicated higher concentration of n-alkanes due to the higher maintenance of organic matter by high clay content in the sediments. n-alkanes 93-102 RNA binding motif protein 4 Homo sapiens 54-58 28164644-6 2016 LandMark met the National Cholesterol Education Program (NCEP) imprecision criteria for TC and TG, but not HDL-C (mean % CV: 2.7%, 3.5%, and 4.7%, respectively). Cholesterol 26-37 RNA binding motif protein 4 Homo sapiens 0-8 28164644-6 2016 LandMark met the National Cholesterol Education Program (NCEP) imprecision criteria for TC and TG, but not HDL-C (mean % CV: 2.7%, 3.5%, and 4.7%, respectively). Technetium 88-90 RNA binding motif protein 4 Homo sapiens 0-8 28164644-6 2016 LandMark met the National Cholesterol Education Program (NCEP) imprecision criteria for TC and TG, but not HDL-C (mean % CV: 2.7%, 3.5%, and 4.7%, respectively). Triglycerides 95-97 RNA binding motif protein 4 Homo sapiens 0-8 25414336-1 2014 Mammalian splicing regulatory protein RNA-binding motif protein 4 (RBM4) has an alanine repeat-containing C-terminal domain (CAD) that confers both nuclear- and splicing speckle-targeting activities. Alanine 80-87 RNA binding motif protein 4 Homo sapiens 67-71 25414336-3 2014 Here we show that the alanine-repeat tracts influence the subnuclear targeting properties of the RBM4 CAD in cultured human cells. Alanine 22-29 RNA binding motif protein 4 Homo sapiens 97-101 25414336-4 2014 Notably, truncation of the alanine tracts redistributed a portion of RBM4 to paraspeckles. Alanine 27-34 RNA binding motif protein 4 Homo sapiens 69-73 25414336-6 2014 On the other hand, alanine-repeat expansion reduced the mobility of RBM4 and impaired its splicing activity. Alanine 19-26 RNA binding motif protein 4 Homo sapiens 68-72 17284590-2 2007 We show here that cell stress such as arsenite exposure induces phosphorylation of RBM4 at serine 309 and also drives its cytoplasmic accumulation and targeting to stress granule via the MKK(3/6)-p38 signaling pathway. arsenite 38-46 RNA binding motif protein 4 Homo sapiens 83-87 23897118-7 2013 This novel molecular path prevents the phosphorylation of RBM4 on serine-309 by p38 MAPK (mitogen-activated protein kinase), which leads to RBM4 accumulation in the cytosol and interaction with Ago2. Serine 66-72 RNA binding motif protein 4 Homo sapiens 58-62 23897118-7 2013 This novel molecular path prevents the phosphorylation of RBM4 on serine-309 by p38 MAPK (mitogen-activated protein kinase), which leads to RBM4 accumulation in the cytosol and interaction with Ago2. Serine 66-72 RNA binding motif protein 4 Homo sapiens 140-144 23897118-8 2013 We further find that microRNA-146a knockdown by antagomirs or protein phosphatase inhibition by okadaic acid increases p38 MAPK phosphorylation and results in RBM4 serine-309 phosphorylation and nuclear relocalization, which disrupts RBM4 and Ago2 interactions and restores TLR4-dependent synthesis of TNFalpha and IL-6. Okadaic Acid 96-108 RNA binding motif protein 4 Homo sapiens 159-163 23897118-8 2013 We further find that microRNA-146a knockdown by antagomirs or protein phosphatase inhibition by okadaic acid increases p38 MAPK phosphorylation and results in RBM4 serine-309 phosphorylation and nuclear relocalization, which disrupts RBM4 and Ago2 interactions and restores TLR4-dependent synthesis of TNFalpha and IL-6. Okadaic Acid 96-108 RNA binding motif protein 4 Homo sapiens 234-238 22678294-7 2012 We show that hypoxia stimulates the formation of a complex that includes the oxygen-regulated hypoxia-inducible factor 2alpha (HIF-2alpha), the RNA-binding protein RBM4 and the cap-binding eIF4E2, an eIF4E homologue. Oxygen 77-83 RNA binding motif protein 4 Homo sapiens 164-168 25140042-5 2014 Overexpressed RBM4 simultaneously bound to the CU-rich elements within the MCL-1 exon2 and the downstream intron, which subsequently facilitated the exclusion of the regulated exon. Copper 47-49 RNA binding motif protein 4 Homo sapiens 14-18 23897118-8 2013 We further find that microRNA-146a knockdown by antagomirs or protein phosphatase inhibition by okadaic acid increases p38 MAPK phosphorylation and results in RBM4 serine-309 phosphorylation and nuclear relocalization, which disrupts RBM4 and Ago2 interactions and restores TLR4-dependent synthesis of TNFalpha and IL-6. Serine 164-170 RNA binding motif protein 4 Homo sapiens 159-163 23527094-3 2013 The C-terminal unstructured domain of RBM4 is evolutionarily divergent and contains stretches of low-complexity sequences, including single amino acid and/or dipeptide repeats. Dipeptides 158-167 RNA binding motif protein 4 Homo sapiens 38-42 17284590-2 2007 We show here that cell stress such as arsenite exposure induces phosphorylation of RBM4 at serine 309 and also drives its cytoplasmic accumulation and targeting to stress granule via the MKK(3/6)-p38 signaling pathway. Serine 91-97 RNA binding motif protein 4 Homo sapiens 83-87 17284590-6 2007 Whereas arsenite treatment promotes RBM4 loading onto IRES mRNAs and enhances RBM4-eIF4A interactions, a nonphosphorylatable mutant of RBM4 was unresponsive to arsenite stress and failed to activate IRES-mediated translation. arsenite 8-16 RNA binding motif protein 4 Homo sapiens 36-40 17284590-6 2007 Whereas arsenite treatment promotes RBM4 loading onto IRES mRNAs and enhances RBM4-eIF4A interactions, a nonphosphorylatable mutant of RBM4 was unresponsive to arsenite stress and failed to activate IRES-mediated translation. arsenite 8-16 RNA binding motif protein 4 Homo sapiens 78-82 17284590-6 2007 Whereas arsenite treatment promotes RBM4 loading onto IRES mRNAs and enhances RBM4-eIF4A interactions, a nonphosphorylatable mutant of RBM4 was unresponsive to arsenite stress and failed to activate IRES-mediated translation. arsenite 8-16 RNA binding motif protein 4 Homo sapiens 78-82 16260624-6 2005 Using minigenes, we demonstrated that RBM4 can activate the selection of skeletal muscle-specific exons, possibly via binding to intronic pyrimidine-rich elements. pyrimidine 138-148 RNA binding motif protein 4 Homo sapiens 38-42