PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
30872532-5	2019	This structure reveals the geometry of the Q/R site that controls calcium flux, suggests association of TARP-stabilized lipids, and demonstrates that the extracellular loop of gamma8 modulates gating by selectively interacting with the GluA2 ligand-binding domain.	Calcium	66-73	TCR gamma alternate reading frame protein	Homo sapiens	104-108
30872532-5	2019	This structure reveals the geometry of the Q/R site that controls calcium flux, suggests association of TARP-stabilized lipids, and demonstrates that the extracellular loop of gamma8 modulates gating by selectively interacting with the GluA2 ligand-binding domain.	gamma8	176-182	TCR gamma alternate reading frame protein	Homo sapiens	104-108
28768197-6	2017	Furthermore, the dual effects of TARPs can account for biphasic steady-state glutamate concentration-response curves-a phenomenon termed "autoinactivation," previously thought to reflect desensitization-mediated AMPAR/TARP dissociation.	Glutamic Acid	77-86	TCR gamma alternate reading frame protein	Homo sapiens	33-37
29906466-5	2018	gamma4 was the most robust TARP in increasing the affinities of CX614 and CTZ on GluR1-flip receptors, but had no such effect on GluR2-flop receptors.	cyclothiazide	74-77	TCR gamma alternate reading frame protein	Homo sapiens	27-31
29906466-8	2018	The modulatory effects of TARPs on ampakine pharmacology are complex, being dependent on both the TARP subtype and the AMPA receptor subtypes/isoforms.	ampakine	35-43	TCR gamma alternate reading frame protein	Homo sapiens	26-30
27865532-10	2017	CONCLUSION: In the absence of a stationary cooling method such as cold-water immersion, tarp-assisted cooling can serve as an alternative, field-expedient method to provide on-site cooling with a satisfactory cooling rate.	Water	71-76	TCR gamma alternate reading frame protein	Homo sapiens	88-92
25164663-0	2014	Molecular mechanisms contributing to TARP regulation of channel conductance and polyamine block of calcium-permeable AMPA receptors.	Polyamines	80-89	TCR gamma alternate reading frame protein	Homo sapiens	37-41
25164663-3	2014	TARP-induced modifications in AMPAR channel behavior include increased single-channel conductance and weakened block of calcium-permeable AMPARs (CP-AMPARs) by endogenous intracellular polyamines.	Calcium	120-127	TCR gamma alternate reading frame protein	Homo sapiens	0-4
25164663-3	2014	TARP-induced modifications in AMPAR channel behavior include increased single-channel conductance and weakened block of calcium-permeable AMPARs (CP-AMPARs) by endogenous intracellular polyamines.	cp-ampars	146-155	TCR gamma alternate reading frame protein	Homo sapiens	0-4
25164663-3	2014	TARP-induced modifications in AMPAR channel behavior include increased single-channel conductance and weakened block of calcium-permeable AMPARs (CP-AMPARs) by endogenous intracellular polyamines.	Polyamines	185-195	TCR gamma alternate reading frame protein	Homo sapiens	0-4
25164663-6	2014	We found that gamma-2 increased the permeability of several cations but not the estimated AMPAR pore size, suggesting that TARP-induced relief of polyamine block does not reflect altered pore diameter.	Polyamines	146-155	TCR gamma alternate reading frame protein	Homo sapiens	123-127
25164663-8	2014	We identified the membrane proximal region of the C terminus as crucial for full TARP-attenuation of polyamine block, whereas complete deletion of the C-tail markedly enhanced the TARP-induced increase in channel conductance; thus, the TARP C-tail influences ion permeation.	Polyamines	101-110	TCR gamma alternate reading frame protein	Homo sapiens	81-85
24038463-1	2013	This study targets the construction of porphyrin assemblies directed by halogen bonds, by utilizing a series of purposely synthesized Sn(axial ligand)2-(5,10,15,20-tetraarylporphyrin) [Sn(L)2-TArP] complexes as building units.	Porphyrins	39-48	TCR gamma alternate reading frame protein	Homo sapiens	192-196
24038463-1	2013	This study targets the construction of porphyrin assemblies directed by halogen bonds, by utilizing a series of purposely synthesized Sn(axial ligand)2-(5,10,15,20-tetraarylporphyrin) [Sn(L)2-TArP] complexes as building units.	Tin	134-136	TCR gamma alternate reading frame protein	Homo sapiens	192-196
22211840-4	2012	Specifically, with AMPA receptors comprising gamma-2, the cerebellar-enriched TARP isoform, CNIH-2 decreases I(KA) /I(Glu)  ratio and decreases cyclothiazide efficacy while having minimal impact on recovery from desensitization and deactivation kinetics.	Glutamic Acid	118-121	TCR gamma alternate reading frame protein	Homo sapiens	78-82
22211840-4	2012	Specifically, with AMPA receptors comprising gamma-2, the cerebellar-enriched TARP isoform, CNIH-2 decreases I(KA) /I(Glu)  ratio and decreases cyclothiazide efficacy while having minimal impact on recovery from desensitization and deactivation kinetics.	cyclothiazide	144-157	TCR gamma alternate reading frame protein	Homo sapiens	78-82
20547132-8	2010	Thus, TARP phosphorylation plays a critical role in regulating AMPA receptor-mediated synaptic transmission via a lipid bilayer interaction.	Lipid Bilayers	114-127	TCR gamma alternate reading frame protein	Homo sapiens	6-10
21969453-2	2011	The prototypical TARP, stargazin (or gamma2), shifts the blocking ability of several AMPAR-selective compounds including the commonly used quinoxalinedione antagonists, CNQX and NBQX.	QUINOXALINEDIONE	139-155	TCR gamma alternate reading frame protein	Homo sapiens	17-21
21969453-2	2011	The prototypical TARP, stargazin (or gamma2), shifts the blocking ability of several AMPAR-selective compounds including the commonly used quinoxalinedione antagonists, CNQX and NBQX.	6-Cyano-7-nitroquinoxaline-2,3-dione	169-173	TCR gamma alternate reading frame protein	Homo sapiens	17-21
21969453-2	2011	The prototypical TARP, stargazin (or gamma2), shifts the blocking ability of several AMPAR-selective compounds including the commonly used quinoxalinedione antagonists, CNQX and NBQX.	2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline	178-182	TCR gamma alternate reading frame protein	Homo sapiens	17-21
21969453-4	2011	Given this, agonist behaviour by CNQX has been speculated to account for its weaker blocking effect on AMPAR-TARP complexes.	6-Cyano-7-nitroquinoxaline-2,3-dione	33-37	TCR gamma alternate reading frame protein	Homo sapiens	109-113
21354776-0	2011	Bio-tarp alternative daily cover prototypes for methane oxidation atop open landfill cells.	Methane	48-55	TCR gamma alternate reading frame protein	Homo sapiens	4-8
21354776-3	2011	The methane oxidation capacity of methanotrophs embedded in a "bio-tarp" was investigated as a means to mitigate methane release from open landfill cells.	Methane	4-11	TCR gamma alternate reading frame protein	Homo sapiens	67-71
21354776-3	2011	The methane oxidation capacity of methanotrophs embedded in a "bio-tarp" was investigated as a means to mitigate methane release from open landfill cells.	methanotrophs	34-47	TCR gamma alternate reading frame protein	Homo sapiens	67-71
21354776-3	2011	The methane oxidation capacity of methanotrophs embedded in a "bio-tarp" was investigated as a means to mitigate methane release from open landfill cells.	Methane	113-120	TCR gamma alternate reading frame protein	Homo sapiens	67-71
21354776-7	2011	Multilayered bio-tarp prototypes consisting of alternating layers of the two geotextiles were found to remove 16% of the methane flowing through the bio-tarp.	Methane	121-128	TCR gamma alternate reading frame protein	Homo sapiens	17-21
21354776-7	2011	Multilayered bio-tarp prototypes consisting of alternating layers of the two geotextiles were found to remove 16% of the methane flowing through the bio-tarp.	Methane	121-128	TCR gamma alternate reading frame protein	Homo sapiens	153-157
21354776-8	2011	The addition of landfill cover soil, compost, or shale amendments to the bio-tarp increased the methane removal up to 32%.	Methane	96-103	TCR gamma alternate reading frame protein	Homo sapiens	77-81
21354776-10	2011	The multilayered bio-tarp and amended bio-tarp configurations were all found to decrease landfill methane flux; however, the performance efficacy of bio-tarps was not significantly different from controls without methanotrophs.	Methane	98-105	TCR gamma alternate reading frame protein	Homo sapiens	21-25
21354776-10	2011	The multilayered bio-tarp and amended bio-tarp configurations were all found to decrease landfill methane flux; however, the performance efficacy of bio-tarps was not significantly different from controls without methanotrophs.	Methane	98-105	TCR gamma alternate reading frame protein	Homo sapiens	42-46
20499060-5	2010	Antibody induction to TARP was also significantly correlated (P = 0.036) with an increase in prostate-specific antigen doubling time (PSADT) in patients with a biochemical (PSA) recurrence following prostatectomy or radiation therapy (N = 19) from in a previous phase 1/2 trial of prostate cancer immunotherapy, G-9802.	g-9802	312-318	TCR gamma alternate reading frame protein	Homo sapiens	22-26
20668138-5	2010	Each of the repeats contains multiple tyrosine residues that are phosphorylated by host cell kinases when Tarp is injected into host cells.	Tyrosine	38-46	TCR gamma alternate reading frame protein	Homo sapiens	106-110
17475805-10	2007	These studies define gamma-7 as a new member of the TARP family that can differentially influence AMPA receptors in cerebellar neurons.	gamma-7	21-28	TCR gamma alternate reading frame protein	Homo sapiens	52-56
17873873-2	2007	Here we show that stargazin, a transmembrane AMPAR regulatory protein (TARP) known to influence transport, gating and desensitization of AMPARs, greatly reduces block of CP-AMPARs by intracellular polyamines.	Polyamines	197-207	TCR gamma alternate reading frame protein	Homo sapiens	31-69
17873873-2	2007	Here we show that stargazin, a transmembrane AMPAR regulatory protein (TARP) known to influence transport, gating and desensitization of AMPARs, greatly reduces block of CP-AMPARs by intracellular polyamines.	Polyamines	197-207	TCR gamma alternate reading frame protein	Homo sapiens	71-75
19773551-9	2009	Furthermore, the CTDs are required for TARP-induced modulation of AMPA receptor gating, including conversion of antagonists to partial agonists and constitutive channel openings.	beta-cyclodextrin tetradecasulfate	17-21	TCR gamma alternate reading frame protein	Homo sapiens	39-43
19560629-0	2009	Ethanol increases desensitization of recombinant GluR-D AMPA receptor and TARP combinations.	Ethanol	0-7	TCR gamma alternate reading frame protein	Homo sapiens	74-78
19146816-0	2009	Autoinactivation of neuronal AMPA receptors via glutamate-regulated TARP interaction.	Glutamic Acid	48-57	TCR gamma alternate reading frame protein	Homo sapiens	68-72
18817736-4	2008	Here, we classify gamma-5 as a distinct class of TARP that modulates specific GluR2-containing AMPA receptors and displays properties entirely dissimilar from canonical TARPs.	gamma-5	18-25	TCR gamma alternate reading frame protein	Homo sapiens	49-53
18605567-7	2008	When the soil beds were tarped using high-density polyethylene (HDPE) or semi-impermeable film (SIF), emissions were reduced to around 40% due to an accumulation of chloropicrin below the tarp.	density polyethylene	42-62	TCR gamma alternate reading frame protein	Homo sapiens	24-28
18605567-7	2008	When the soil beds were tarped using high-density polyethylene (HDPE) or semi-impermeable film (SIF), emissions were reduced to around 40% due to an accumulation of chloropicrin below the tarp.	chloropicrin	165-177	TCR gamma alternate reading frame protein	Homo sapiens	24-28
17975069-4	2007	A crystal structure of CNQX bound to the TARP-less AMPA receptor ligand-binding domain showed that, although CNQX induces partial domain closure, this movement is not transduced into linker separation, suggesting that TARPs may increase agonist efficacy by strengthening the coupling between domain closure and channel opening.	6-Cyano-7-nitroquinoxaline-2,3-dione	23-27	TCR gamma alternate reading frame protein	Homo sapiens	41-45
17975069-4	2007	A crystal structure of CNQX bound to the TARP-less AMPA receptor ligand-binding domain showed that, although CNQX induces partial domain closure, this movement is not transduced into linker separation, suggesting that TARPs may increase agonist efficacy by strengthening the coupling between domain closure and channel opening.	6-Cyano-7-nitroquinoxaline-2,3-dione	109-113	TCR gamma alternate reading frame protein	Homo sapiens	41-45
17873873-2	2007	Here we show that stargazin, a transmembrane AMPAR regulatory protein (TARP) known to influence transport, gating and desensitization of AMPARs, greatly reduces block of CP-AMPARs by intracellular polyamines.	cp-ampars	170-179	TCR gamma alternate reading frame protein	Homo sapiens	31-69
17873873-2	2007	Here we show that stargazin, a transmembrane AMPAR regulatory protein (TARP) known to influence transport, gating and desensitization of AMPARs, greatly reduces block of CP-AMPARs by intracellular polyamines.	cp-ampars	170-179	TCR gamma alternate reading frame protein	Homo sapiens	71-75
11719440-6	2001	We also demonstrated that TARP expression is up-regulated by testosterone in LNCaP cells that express a functional androgen receptor.	Testosterone	61-73	TCR gamma alternate reading frame protein	Homo sapiens	26-30
16738389-11	2006	Surface water application can be as effective, and less expensive than, standard HDPE tarp.	Water	8-13	TCR gamma alternate reading frame protein	Homo sapiens	86-90
15972471-0	2005	Tyrosine phosphorylation of the chlamydial effector protein Tarp is species specific and not required for recruitment of actin.	Tyrosine	0-8	TCR gamma alternate reading frame protein	Homo sapiens	60-64
15972471-2	2005	Recently, a Chlamydia trachomatis type III secreted effector protein, Tarp, was found to be translocated and tyrosine phosphorylated at the site of entry and associated with the recruitment of actin that coincides with endocytosis.	Tyrosine	109-117	TCR gamma alternate reading frame protein	Homo sapiens	70-74
15972471-5	2005	Here we have ectopically expressed distinct domains of Tarp in HeLa 229 cells and demonstrated that tyrosine phosphorylation occurs primarily within the repeat region, while recruitment of actin is mediated by the C-terminal domain of the protein.	Tyrosine	100-108	TCR gamma alternate reading frame protein	Homo sapiens	55-59
15972471-8	2005	Ectopic expression of full-length C. trachomatis and C. caviae Tarp confirmed that both recruit actin but only C. trachomatis Tarp is tyrosine phosphorylated.	Tyrosine	134-142	TCR gamma alternate reading frame protein	Homo sapiens	126-130
15758178-8	2005	Functionally, our data suggest that AMPA receptors complexed with stargazin (and possibly also with other TARPs) at the postsynaptic membrane are significantly more responsive to synaptically released glutamate compared with AMPA receptors lacking stargazin/TARP interaction.	Glutamic Acid	201-210	TCR gamma alternate reading frame protein	Homo sapiens	106-110
12865322-2	2003	Here we demonstrate that TARP expression is regulated by testosterone at the transcriptional level through specific binding of androgen receptor to an androgen response element in the proximal TARP promoter.	Testosterone	57-69	TCR gamma alternate reading frame protein	Homo sapiens	25-29
12865322-2	2003	Here we demonstrate that TARP expression is regulated by testosterone at the transcriptional level through specific binding of androgen receptor to an androgen response element in the proximal TARP promoter.	Testosterone	57-69	TCR gamma alternate reading frame protein	Homo sapiens	193-197
35246481-9	2022	The drug also modifies hallmark features of AMPAR pharmacology, including the TARP-dependent actions of intracellular polyamines and the partial agonist kainate.	Polyamines	118-128	TCR gamma alternate reading frame protein	Homo sapiens	78-82
10510084-4	1999	To better understand the role of a key second messenger, calcium, in governing thymocyte maturation, we measured the intracellular free calcium concentration ([Ca2+]i) response to changes in TCR avidity and costimulation.	Calcium	57-64	TCR gamma alternate reading frame protein	Homo sapiens	191-194
10510084-4	1999	To better understand the role of a key second messenger, calcium, in governing thymocyte maturation, we measured the intracellular free calcium concentration ([Ca2+]i) response to changes in TCR avidity and costimulation.	Calcium	136-143	TCR gamma alternate reading frame protein	Homo sapiens	191-194
10510084-9	1999	These data suggest that calcium plays a central role in encoding the nature of the TCR signal received by thymocytes and, consequently, a role in thymic selection.	Calcium	24-31	TCR gamma alternate reading frame protein	Homo sapiens	83-86
35246481-9	2022	The drug also modifies hallmark features of AMPAR pharmacology, including the TARP-dependent actions of intracellular polyamines and the partial agonist kainate.	Kainic Acid	153-160	TCR gamma alternate reading frame protein	Homo sapiens	78-82
32994336-10	2020	Thus, isoform-specific differences in TARP modulation of recovery from desensitization influence receptor responses to repeated brief applications of glutamate, and these differences may impact frequency-dependent synaptic signaling in the mammalian central nervous system.Significance Statement:AMPA receptors are major determinants of excitatory synaptic strength.	Glutamic Acid	150-159	TCR gamma alternate reading frame protein	Homo sapiens	38-42
32994336-15	2020	We observed that the TARP isoforms and duration of glutamate application uniquely modulate time constants and the proportion of fast and slow components through a previously unidentified TARP domain.	Glutamic Acid	51-60	TCR gamma alternate reading frame protein	Homo sapiens	187-191