PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 2751707-3 1989 Relative efficiency of the mono- and dinucleotide donors depends on the 5"-terminal nucleoside moiety of the dinucleotide: upon ligation with the minimal phosphate acceptor GpUpC, dinucleotides pApA, pApC, and pApU are more effective than nucleotide diphosphate pAp; pGpC is more effective than pGp; efficiencies of pCpC and pCp are almost identical, and efficiency of pUpU is slightly lower than that of pUp. mono- and dinucleotide 27-49 protocadherin 8 Homo sapiens 200-204 2547451-4 1989 Both the MNP-PAPC and MNP-AA spin adducts showed some restriction of rotational motion when in the liposome bilayer (rotational correlation times 0.72 and 0.69.10(-9) s, respectively), and nitrogen hyperfine coupling constants (14.94-14.96 G) consistent with a hydrophobic localization. Nitrogen 189-197 protocadherin 8 Homo sapiens 13-17 2751707-3 1989 Relative efficiency of the mono- and dinucleotide donors depends on the 5"-terminal nucleoside moiety of the dinucleotide: upon ligation with the minimal phosphate acceptor GpUpC, dinucleotides pApA, pApC, and pApU are more effective than nucleotide diphosphate pAp; pGpC is more effective than pGp; efficiencies of pCpC and pCp are almost identical, and efficiency of pUpU is slightly lower than that of pUp. Nucleosides 84-94 protocadherin 8 Homo sapiens 200-204 2751707-3 1989 Relative efficiency of the mono- and dinucleotide donors depends on the 5"-terminal nucleoside moiety of the dinucleotide: upon ligation with the minimal phosphate acceptor GpUpC, dinucleotides pApA, pApC, and pApU are more effective than nucleotide diphosphate pAp; pGpC is more effective than pGp; efficiencies of pCpC and pCp are almost identical, and efficiency of pUpU is slightly lower than that of pUp. Dinucleoside Phosphates 37-49 protocadherin 8 Homo sapiens 200-204 2751707-3 1989 Relative efficiency of the mono- and dinucleotide donors depends on the 5"-terminal nucleoside moiety of the dinucleotide: upon ligation with the minimal phosphate acceptor GpUpC, dinucleotides pApA, pApC, and pApU are more effective than nucleotide diphosphate pAp; pGpC is more effective than pGp; efficiencies of pCpC and pCp are almost identical, and efficiency of pUpU is slightly lower than that of pUp. Dinucleoside Phosphates 180-193 protocadherin 8 Homo sapiens 200-204 3801406-3 1986 PA-PC vesicles in the presence of calcium show a rapid but limited intermixing of vesicle lipids and contents, the extent of which increases as the vesicle size decreases or the PA content increases. Calcium 34-41 protocadherin 8 Homo sapiens 0-5 3600626-2 1987 A model of crystallization of the (pGpT)n.(pApC)n + spermine system]. Spermine 52-60 protocadherin 8 Homo sapiens 43-47 3122758-2 1988 The nucleolytic activity of the Ala 46 mutant enzyme against pGpC decreased to 0.4% of that of the wild-type enzyme, on the other hand its activity against pApC increased. Alanine 32-35 protocadherin 8 Homo sapiens 156-160 3271481-9 1987 The experimental phase diagrams for the (pGpT)n (pApC)n-spermine system (n = 2,3,4) have been analyzed ion terms of this model and the values of the binding constants of spermine and Mg2+ ions binding to duplexes have been determined. Spermine 56-64 protocadherin 8 Homo sapiens 49-53 3271481-9 1987 The experimental phase diagrams for the (pGpT)n (pApC)n-spermine system (n = 2,3,4) have been analyzed ion terms of this model and the values of the binding constants of spermine and Mg2+ ions binding to duplexes have been determined. Spermine 170-178 protocadherin 8 Homo sapiens 49-53 3801406-8 1986 By correlating calorimetric and fluorometric measurements of lipid lateral segregation and mixing of vesicle components, we can demonstrate that lipid segregation is at least strongly correlated with calcium-promoted coalescence of PA-PC vesicles and is essential to the magnesium-promoted interactions of vesicles of low PA contents. Calcium 200-207 protocadherin 8 Homo sapiens 232-237 3801406-8 1986 By correlating calorimetric and fluorometric measurements of lipid lateral segregation and mixing of vesicle components, we can demonstrate that lipid segregation is at least strongly correlated with calcium-promoted coalescence of PA-PC vesicles and is essential to the magnesium-promoted interactions of vesicles of low PA contents. Magnesium 271-280 protocadherin 8 Homo sapiens 232-237 4084567-2 1985 Calorimetrically derived phase diagrams for dimyristoyl- and dielaidoyl-substituted PA-PC and PA-PE mixtures indicate that these species are readily miscible in the absence of calcium but phase-separate very extensively in the presence of high levels of calcium (30 mM). dimyristoyl- and dielaidoyl 44-71 protocadherin 8 Homo sapiens 84-89 3005829-4 1986 Following demethylation of rauwolscine or yohimbine, the resultant carboxylic acid derivatives were reacted with 4-aminophenethylamine to yield the respective 4-aminophenethyl carboxamides, 17 alpha-hydroxy-20 alpha-yohimban-16 beta-[N-4-amino-phenethyl]carboxamide (rau-pAPC) and 17 alpha-hydroxy-20 beta-yohimban-16 alpha-[N-4-aminophenethyl]carboxamide. Yohimbine 27-38 protocadherin 8 Homo sapiens 271-275 3005829-4 1986 Following demethylation of rauwolscine or yohimbine, the resultant carboxylic acid derivatives were reacted with 4-aminophenethylamine to yield the respective 4-aminophenethyl carboxamides, 17 alpha-hydroxy-20 alpha-yohimban-16 beta-[N-4-amino-phenethyl]carboxamide (rau-pAPC) and 17 alpha-hydroxy-20 beta-yohimban-16 alpha-[N-4-aminophenethyl]carboxamide. Carboxylic Acids 67-82 protocadherin 8 Homo sapiens 271-275 3005829-4 1986 Following demethylation of rauwolscine or yohimbine, the resultant carboxylic acid derivatives were reacted with 4-aminophenethylamine to yield the respective 4-aminophenethyl carboxamides, 17 alpha-hydroxy-20 alpha-yohimban-16 beta-[N-4-amino-phenethyl]carboxamide (rau-pAPC) and 17 alpha-hydroxy-20 beta-yohimban-16 alpha-[N-4-aminophenethyl]carboxamide. 2-(4-aminophenyl)ethylamine 113-134 protocadherin 8 Homo sapiens 271-275 3005829-4 1986 Following demethylation of rauwolscine or yohimbine, the resultant carboxylic acid derivatives were reacted with 4-aminophenethylamine to yield the respective 4-aminophenethyl carboxamides, 17 alpha-hydroxy-20 alpha-yohimban-16 beta-[N-4-amino-phenethyl]carboxamide (rau-pAPC) and 17 alpha-hydroxy-20 beta-yohimban-16 alpha-[N-4-aminophenethyl]carboxamide. 4-aminophenethyl carboxamides 159-188 protocadherin 8 Homo sapiens 271-275 3005829-5 1986 In competitive inhibition studies using rat renal membranes and the radioligand [3H]rauwolscine, rau-pAPC (Ki = 11 +/- 1 nM) exhibited a 14-fold greater affinity than the corresponding yohimbine derivative (Ki = 136 +/- 45 nM). Rauwolscine 80-95 protocadherin 8 Homo sapiens 101-105 3005829-5 1986 In competitive inhibition studies using rat renal membranes and the radioligand [3H]rauwolscine, rau-pAPC (Ki = 11 +/- 1 nM) exhibited a 14-fold greater affinity than the corresponding yohimbine derivative (Ki = 136 +/- 45 nM). Yohimbine 185-194 protocadherin 8 Homo sapiens 101-105 3005829-6 1986 The higher affinity compound, rau-pAPC, was radioiodinated by the chloramine T method, and the product, 125I-rau-pAPC [17 alpha-hydroxy-20 alpha-yohimban-16 beta-(N-4-amino-3 -[125I]iodophenethyl)carboxamide], was purified by reverse phase HPLC to high specific activity (2175 Ci/mmol) and its binding characteristics were investigated in rat kidney membranes. chloramine-T 66-78 protocadherin 8 Homo sapiens 34-38 3005829-6 1986 The higher affinity compound, rau-pAPC, was radioiodinated by the chloramine T method, and the product, 125I-rau-pAPC [17 alpha-hydroxy-20 alpha-yohimban-16 beta-(N-4-amino-3 -[125I]iodophenethyl)carboxamide], was purified by reverse phase HPLC to high specific activity (2175 Ci/mmol) and its binding characteristics were investigated in rat kidney membranes. 17 alpha-hydroxy-20 alpha-yohimban-16 beta-(n-4-amino-3 -[125i]iodophenethyl)carboxamide 119-207 protocadherin 8 Homo sapiens 113-117 3005829-8 1986 In competition studies, alpha-adrenergic antagonists and agonists inhibited the binding of 125I-rau-pAPC with a potency order consistent with an interaction at alpha 2-adrenergic receptors (rauwolscine greater than phentolamine greater than prazosin; clonidine greater than (-)-epinephrine greater than (-)-norepinephrine greater than dopamine greater than (+)-epinephrine). Yohimbine 190-201 protocadherin 8 Homo sapiens 100-104 3005829-8 1986 In competition studies, alpha-adrenergic antagonists and agonists inhibited the binding of 125I-rau-pAPC with a potency order consistent with an interaction at alpha 2-adrenergic receptors (rauwolscine greater than phentolamine greater than prazosin; clonidine greater than (-)-epinephrine greater than (-)-norepinephrine greater than dopamine greater than (+)-epinephrine). Phentolamine 215-227 protocadherin 8 Homo sapiens 100-104 3005829-8 1986 In competition studies, alpha-adrenergic antagonists and agonists inhibited the binding of 125I-rau-pAPC with a potency order consistent with an interaction at alpha 2-adrenergic receptors (rauwolscine greater than phentolamine greater than prazosin; clonidine greater than (-)-epinephrine greater than (-)-norepinephrine greater than dopamine greater than (+)-epinephrine). Prazosin 241-249 protocadherin 8 Homo sapiens 100-104 3005829-8 1986 In competition studies, alpha-adrenergic antagonists and agonists inhibited the binding of 125I-rau-pAPC with a potency order consistent with an interaction at alpha 2-adrenergic receptors (rauwolscine greater than phentolamine greater than prazosin; clonidine greater than (-)-epinephrine greater than (-)-norepinephrine greater than dopamine greater than (+)-epinephrine). Clonidine 251-260 protocadherin 8 Homo sapiens 100-104 3005829-8 1986 In competition studies, alpha-adrenergic antagonists and agonists inhibited the binding of 125I-rau-pAPC with a potency order consistent with an interaction at alpha 2-adrenergic receptors (rauwolscine greater than phentolamine greater than prazosin; clonidine greater than (-)-epinephrine greater than (-)-norepinephrine greater than dopamine greater than (+)-epinephrine). Epinephrine 274-289 protocadherin 8 Homo sapiens 100-104 3005829-8 1986 In competition studies, alpha-adrenergic antagonists and agonists inhibited the binding of 125I-rau-pAPC with a potency order consistent with an interaction at alpha 2-adrenergic receptors (rauwolscine greater than phentolamine greater than prazosin; clonidine greater than (-)-epinephrine greater than (-)-norepinephrine greater than dopamine greater than (+)-epinephrine). Norepinephrine 303-321 protocadherin 8 Homo sapiens 100-104 3005829-8 1986 In competition studies, alpha-adrenergic antagonists and agonists inhibited the binding of 125I-rau-pAPC with a potency order consistent with an interaction at alpha 2-adrenergic receptors (rauwolscine greater than phentolamine greater than prazosin; clonidine greater than (-)-epinephrine greater than (-)-norepinephrine greater than dopamine greater than (+)-epinephrine). Dopamine 335-343 protocadherin 8 Homo sapiens 100-104 3005829-8 1986 In competition studies, alpha-adrenergic antagonists and agonists inhibited the binding of 125I-rau-pAPC with a potency order consistent with an interaction at alpha 2-adrenergic receptors (rauwolscine greater than phentolamine greater than prazosin; clonidine greater than (-)-epinephrine greater than (-)-norepinephrine greater than dopamine greater than (+)-epinephrine). Epinephrine 357-372 protocadherin 8 Homo sapiens 100-104 4084567-2 1985 Calorimetrically derived phase diagrams for dimyristoyl- and dielaidoyl-substituted PA-PC and PA-PE mixtures indicate that these species are readily miscible in the absence of calcium but phase-separate very extensively in the presence of high levels of calcium (30 mM). Calcium 176-183 protocadherin 8 Homo sapiens 84-89 4084567-2 1985 Calorimetrically derived phase diagrams for dimyristoyl- and dielaidoyl-substituted PA-PC and PA-PE mixtures indicate that these species are readily miscible in the absence of calcium but phase-separate very extensively in the presence of high levels of calcium (30 mM). Calcium 254-261 protocadherin 8 Homo sapiens 84-89 4084567-4 1985 The kinetics of calcium-induced lateral phase separations were examined for dioleoyl- and dielaidoyl-substituted PA-PC unilamellar vesicles labeled with fluorescent (C12-NBD-acyl) PA or PC, whose fluorescence becomes partially quenched upon phase separation. dioleoyl- and dielaidoyl 76-100 protocadherin 8 Homo sapiens 113-118 4084567-5 1985 Our results indicate that, for the PA-PC system, lateral phase separation is very rapid (approximately less than 1 s) after calcium addition and develops partially (possibly in only one face of the bilayer) when calcium is present only on one side of the bilayer. Calcium 124-131 protocadherin 8 Homo sapiens 35-40 4084567-5 1985 Our results indicate that, for the PA-PC system, lateral phase separation is very rapid (approximately less than 1 s) after calcium addition and develops partially (possibly in only one face of the bilayer) when calcium is present only on one side of the bilayer. Calcium 212-219 protocadherin 8 Homo sapiens 35-40 22273848-5 2012 Treatment of NPC cells with 5-aza-2"-deoxycytidine and/or trichostatin A could restore PCDH8 expression. Decitabine 28-50 protocadherin 8 Homo sapiens 87-92 4082107-4 1985 For platelet-derived membranes and for equimolar, charged-lipid/phosphatidylcholine (PC) vesicles, the critical concentrations increased in the following order: platelet-derived membranes approximately equal to phosphatidylserine (PS) approximately equal to phosphatidic acid (PA) less than monomethyl PA and monoethyl PA much less than phosphatidylinositol and phosphatidylglycerol. Phosphatidylcholines 64-83 protocadherin 8 Homo sapiens 85-87 26539811-1 2015 In this study, a biomemory chip consisting of a myoglobin/carbon nanotube (CNT) heterolayer is fabricated via the protein-adsorption-precipitation-crosslinking (PAPC) technique for electrochemical signal enhancement, long-term stability, and improved memory function. Carbon 58-64 protocadherin 8 Homo sapiens 161-165 24918924-5 2014 RESULTS: In HAEC, TLR4 antagonism with eritoran inhibited LPS-induced mRNA expression of IL-6, IL-8, TNFalpha, CCL-2, VCAM and ICAM (P<0.05 for all) and inhibited Ox-PAPC-induced mRNA expression of IL-8 (P<0.05) and IL-6, albeit not to a statistically significant level (p = 0.07). eritoran 39-47 protocadherin 8 Homo sapiens 169-173 32798398-5 2020 After DAC treatment, caspase 3, BAX and PCDH8 expression levels increased, while BCL-2 and CCND1 expression levels decreased in Jeko-1 and Grante519 cells, but there was no significant difference in NF-kappaB expression. Decitabine 6-9 protocadherin 8 Homo sapiens 40-45 32798398-6 2020 High dose BTZ could significantly inhibit the proliferation and induce apoptosis of Jeko-1 and Grante519 cells which shows a dose-and time-dependent manner; single drug BTZ could increase the expression level of Caspase 3 and BAX, and decrease the expression level of NF-kappaB, BCL-2 and CCDN1 in Jeko-1 and Grante519 cells, but there was significant difference in PCDH8 expression level. btz 10-13 protocadherin 8 Homo sapiens 366-371 32798398-6 2020 High dose BTZ could significantly inhibit the proliferation and induce apoptosis of Jeko-1 and Grante519 cells which shows a dose-and time-dependent manner; single drug BTZ could increase the expression level of Caspase 3 and BAX, and decrease the expression level of NF-kappaB, BCL-2 and CCDN1 in Jeko-1 and Grante519 cells, but there was significant difference in PCDH8 expression level. btz 169-172 protocadherin 8 Homo sapiens 366-371 32798398-7 2020 Compared with single-drug treatment group, DAC combined with BTZ significantly increased the inhibitory rate and apoptotic rate of Jeko-1 and Grante519 cells; PCDH8, Caspase 3 and BAX expression levels significantly increased, and the expression levels of NF-kappaB, BCL-2 and CCND1 significantly decreased in Jeko-1 and Grante519 cells. Decitabine 43-46 protocadherin 8 Homo sapiens 159-164 31981722-0 2020 Serotonin induces Arcadlin in hippocampal neurons. Serotonin 0-9 protocadherin 8 Homo sapiens 18-26 28927088-7 2017 Restoration of PCDH8 decreased phosphorylated (p)-Rac-alpha serine/threonine-protein kinase (AKT) [Threonine (T)308/Serine (S)473] and p-glycogen synthase kinase-3beta (p-GSK3beta) (S9) protein expression, thereby reducing the level of beta-catenin when compared with the control. Threonine 99-108 protocadherin 8 Homo sapiens 15-20 28927088-7 2017 Restoration of PCDH8 decreased phosphorylated (p)-Rac-alpha serine/threonine-protein kinase (AKT) [Threonine (T)308/Serine (S)473] and p-glycogen synthase kinase-3beta (p-GSK3beta) (S9) protein expression, thereby reducing the level of beta-catenin when compared with the control. Serine 116-122 protocadherin 8 Homo sapiens 15-20 27181766-6 2015 To assess the roles of these residues in plug stabilization, we used patch-clamp electrophysiology to compare the activity of wild-type and mutant PapC channels containing alanine substitutions at these sites. Alanine 172-179 protocadherin 8 Homo sapiens 147-151 22273848-5 2012 Treatment of NPC cells with 5-aza-2"-deoxycytidine and/or trichostatin A could restore PCDH8 expression. trichostatin A 58-72 protocadherin 8 Homo sapiens 87-92 22941331-7 2012 The demethylation reagent 5-aza-2"-deoxycytidine was able to restore or upregulate PCDH8 expression in gastric cancer cell lines. Decitabine 26-48 protocadherin 8 Homo sapiens 95-100 21484165-0 2011 Modulation of endothelial cell proliferation and capillary network formation by the ox-LDL component: 1-palmitoyl-2-archidonoyl-sn-glycero-3-phosphocholine (ox-PAPC). 1-palmitoyl-2-archidonoyl-sn-glycero-3-phosphocholine 102-155 protocadherin 8 Homo sapiens 160-164 22402363-3 2012 The oxidation products of phospholipids, including oxidized 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine (Ox-PAPC), accumulate in atherosclerotic lesions and strongly induce IL-8 in human aortic endothelial cells (HAECs). Phospholipids 26-39 protocadherin 8 Homo sapiens 119-123 22402363-3 2012 The oxidation products of phospholipids, including oxidized 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine (Ox-PAPC), accumulate in atherosclerotic lesions and strongly induce IL-8 in human aortic endothelial cells (HAECs). 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine 60-114 protocadherin 8 Homo sapiens 119-123 22402363-10 2012 We provide evidence for one mechanism of Ox-PAPC activation of ADAM involving covalent binding of Ox-PAPC to cysteine on ADAM. Cysteine 109-117 protocadherin 8 Homo sapiens 44-48 22402363-10 2012 We provide evidence for one mechanism of Ox-PAPC activation of ADAM involving covalent binding of Ox-PAPC to cysteine on ADAM. Cysteine 109-117 protocadherin 8 Homo sapiens 101-105 22402363-11 2012 Free thiol cysteine analogs showed inhibition of IL-8 induction by Ox-PAPC, and both a cysteine analog and a cell surface thiol blocker strongly inhibited ADAM activity induction by Ox-PAPC. thiol-cysteine 5-19 protocadherin 8 Homo sapiens 70-74 22402363-11 2012 Free thiol cysteine analogs showed inhibition of IL-8 induction by Ox-PAPC, and both a cysteine analog and a cell surface thiol blocker strongly inhibited ADAM activity induction by Ox-PAPC. Cysteine 11-19 protocadherin 8 Homo sapiens 70-74 22402363-11 2012 Free thiol cysteine analogs showed inhibition of IL-8 induction by Ox-PAPC, and both a cysteine analog and a cell surface thiol blocker strongly inhibited ADAM activity induction by Ox-PAPC. Sulfhydryl Compounds 5-10 protocadherin 8 Homo sapiens 70-74 21484165-3 2011 Effects of oxidized 1-palmitoyl-2-archidonoyl-sn-glycero-3-phosphocholine (ox-PAPC) mimic actions of minimally modified LDL in vivo. 1-palmitoyl-2-archidonoyl-sn-glycero-3-phosphocholine 20-73 protocadherin 8 Homo sapiens 78-82 21737788-1 2011 RATIONALE: Oxidized palmitoyl arachidonyl phosphatidylcholine (Ox-PAPC) accumulates in atherosclerotic lesions, is proatherogenic, and influences the expression of more than 1000 genes in endothelial cells. palmitoyl arachidonyl phosphatidylcholine 20-61 protocadherin 8 Homo sapiens 66-70 17065348-4 2006 We have compared the ability of HDL from people with type 2 diabetes (n = 36) with no coronary heart disease (CHD) to metabolize oxidized palmitoyl arachidonyl phosphatidylcholine (ox-PAPC), a major product of LDL oxidation and a PON1 substrate, with that of HDL isolated from healthy control subjects (n = 19) and people with CHD but no diabetes (n = 37). palmitoyl arachidonyl phosphatidylcholine 138-179 protocadherin 8 Homo sapiens 184-188 20307106-1 2010 Previous studies have shown that oxidized products of the phospholipid PAPC (Ox-PAPC) are strong activators of aortic endothelial cells and play an important role in atherosclerosis and other inflammatory diseases. Phospholipids 58-70 protocadherin 8 Homo sapiens 71-75 20307106-1 2010 Previous studies have shown that oxidized products of the phospholipid PAPC (Ox-PAPC) are strong activators of aortic endothelial cells and play an important role in atherosclerosis and other inflammatory diseases. Phospholipids 58-70 protocadherin 8 Homo sapiens 80-84 19595352-0 2010 Lovastatin inhibits oxidized L-A-phosphatidylcholine B-arachidonoyl-gamma-palmitoyl (ox-PAPC)-stimulated interleukin-8 mRNA and protein synthesis in human aortic endothelial cells by depleting stores of geranylgeranyl pyrophosphate. Lovastatin 0-10 protocadherin 8 Homo sapiens 88-92 19595352-0 2010 Lovastatin inhibits oxidized L-A-phosphatidylcholine B-arachidonoyl-gamma-palmitoyl (ox-PAPC)-stimulated interleukin-8 mRNA and protein synthesis in human aortic endothelial cells by depleting stores of geranylgeranyl pyrophosphate. l-a-phosphatidylcholine b-arachidonoyl-gamma-palmitoyl 29-83 protocadherin 8 Homo sapiens 88-92 19595352-0 2010 Lovastatin inhibits oxidized L-A-phosphatidylcholine B-arachidonoyl-gamma-palmitoyl (ox-PAPC)-stimulated interleukin-8 mRNA and protein synthesis in human aortic endothelial cells by depleting stores of geranylgeranyl pyrophosphate. geranylgeranyl pyrophosphate 203-231 protocadherin 8 Homo sapiens 88-92 19595352-1 2010 Human aortic endothelial cells (HAEC) exposed to 50 microg/ml oxidized L-A-phosphatidylcholine B-arachidonoyl-gamma-palmitoyl (ox-PAPC) for 6h increased in interleukin-8 mRNA and protein levels. l-a-phosphatidylcholine b-arachidonoyl-gamma-palmitoyl 71-125 protocadherin 8 Homo sapiens 130-134 19595352-3 2010 Mevalonate (200 microM) reversed the inhibition of ox-PAPC-stimulated mRNA and protein levels by lovastatin, indicating the inhibitory effect of lovastatin was due to inhibition of mevalonate synthesis. Mevalonic Acid 0-10 protocadherin 8 Homo sapiens 54-58 19595352-3 2010 Mevalonate (200 microM) reversed the inhibition of ox-PAPC-stimulated mRNA and protein levels by lovastatin, indicating the inhibitory effect of lovastatin was due to inhibition of mevalonate synthesis. Lovastatin 97-107 protocadherin 8 Homo sapiens 54-58 19595352-3 2010 Mevalonate (200 microM) reversed the inhibition of ox-PAPC-stimulated mRNA and protein levels by lovastatin, indicating the inhibitory effect of lovastatin was due to inhibition of mevalonate synthesis. Lovastatin 145-155 protocadherin 8 Homo sapiens 54-58 19595352-3 2010 Mevalonate (200 microM) reversed the inhibition of ox-PAPC-stimulated mRNA and protein levels by lovastatin, indicating the inhibitory effect of lovastatin was due to inhibition of mevalonate synthesis. Mevalonic Acid 181-191 protocadherin 8 Homo sapiens 54-58 19595352-4 2010 Addition of the geranylgeraniol (GGOL, 10 microM) but not farnesol (FOL, 10 microM), reversed the inhibitory effect of lovastatin on interleukin-8 mRNA and protein levels stimulated by ox-PAPC, indicating that lovastatin exerted its effect by inhibiting stores of geranylgeranyl pyrophosphate (GGPP) which are necessary for geranylgeranylation of proteins. geranylgeraniol 16-31 protocadherin 8 Homo sapiens 188-192 19595352-4 2010 Addition of the geranylgeraniol (GGOL, 10 microM) but not farnesol (FOL, 10 microM), reversed the inhibitory effect of lovastatin on interleukin-8 mRNA and protein levels stimulated by ox-PAPC, indicating that lovastatin exerted its effect by inhibiting stores of geranylgeranyl pyrophosphate (GGPP) which are necessary for geranylgeranylation of proteins. geranylgeraniol 33-37 protocadherin 8 Homo sapiens 188-192 19375500-1 2009 Previous studies from our group have demonstrated that oxidized 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine (Ox-PAPC) activates over 1000 genes in human aortic endothelial cells (HAECs). 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine 64-118 protocadherin 8 Homo sapiens 123-127 19375500-3 2009 Previous studies from our lab and others suggested that transcriptional regulation by Ox-PAPC may be controlled, at least in part, by reactive oxygen species. Reactive Oxygen Species 134-157 protocadherin 8 Homo sapiens 89-93 19375500-5 2009 Our data demonstrate that Ox-PAPC increases reactive oxygen species formation in HAECs as seen by DCF fluorescence. Reactive Oxygen Species 44-67 protocadherin 8 Homo sapiens 29-33 19375500-5 2009 Our data demonstrate that Ox-PAPC increases reactive oxygen species formation in HAECs as seen by DCF fluorescence. Pentostatin 98-101 protocadherin 8 Homo sapiens 29-33 17988630-2 2007 Here, we report a pathway of regulated endocytosis triggered by arcadlin, a protocadherin induced by electroconvulsive and other excitatory stimuli in hippocampal neurons. protocadherin 76-89 protocadherin 8 Homo sapiens 64-72 17379837-1 2007 OBJECTIVE: Oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycero-phosphorylcholine (Ox-PAPC) and its component phospholipid, 1-palmitoyl-2-(5,6 epoxyisoprostanoyl)-sn-glycero-3-phosphocholine (PEIPC), which are present in atherosclerotic lesions, activate endothelial cells to induce a complex inflammatory and pro-oxidant response. 1-palmitoyl-2-arachidonyl-sn-3-glycero-phosphorylcholine 20-76 protocadherin 8 Homo sapiens 81-85 17379837-1 2007 OBJECTIVE: Oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycero-phosphorylcholine (Ox-PAPC) and its component phospholipid, 1-palmitoyl-2-(5,6 epoxyisoprostanoyl)-sn-glycero-3-phosphocholine (PEIPC), which are present in atherosclerotic lesions, activate endothelial cells to induce a complex inflammatory and pro-oxidant response. Phospholipids 105-117 protocadherin 8 Homo sapiens 81-85 17379837-1 2007 OBJECTIVE: Oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycero-phosphorylcholine (Ox-PAPC) and its component phospholipid, 1-palmitoyl-2-(5,6 epoxyisoprostanoyl)-sn-glycero-3-phosphocholine (PEIPC), which are present in atherosclerotic lesions, activate endothelial cells to induce a complex inflammatory and pro-oxidant response. 1-palmitoyl-2-(5,6 epoxyisoprostanoyl)-sn-glycero-3-phosphocholine 119-185 protocadherin 8 Homo sapiens 81-85 17379837-1 2007 OBJECTIVE: Oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycero-phosphorylcholine (Ox-PAPC) and its component phospholipid, 1-palmitoyl-2-(5,6 epoxyisoprostanoyl)-sn-glycero-3-phosphocholine (PEIPC), which are present in atherosclerotic lesions, activate endothelial cells to induce a complex inflammatory and pro-oxidant response. PEIPC 187-192 protocadherin 8 Homo sapiens 81-85 17379837-2 2007 Previously, we demonstrated induction of genes regulating chemotaxis, sterol biosynthesis, the unfolded protein response, and redox homeostasis by Ox-PAPC in human aortic endothelial cells (HAECs). Sterols 70-76 protocadherin 8 Homo sapiens 150-154 17379837-6 2007 These effects were associated with HDL inhibition of Ox-PAPC-induced c-Src, signal transducer and activator of transcription 3, and SREBP activation, alterations in endothelial nitric oxide synthase phosphorylation (previously associated with the inflammatory action of Ox-PAPC), and a decrease in superoxide formation. Superoxides 298-308 protocadherin 8 Homo sapiens 56-60 18757839-1 2009 Oxidized-1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine (Ox-PAPC) has been demonstrated to accumulate in atherosclerotic lesions and regulates expression of more than 1,000 genes in human aortic endothelial cell (HAEC). 1-palmitoyl-2-arachidonyl-sn-glycerol-3-phosphocholine 9-63 protocadherin 8 Homo sapiens 68-72 18757839-6 2009 We hypothesized that PMET activation by Ox-PAPC causes intracellular NAD(P)H depletion, which leads to the increased oxidative stress and HO-1 induction. nad(p)h 69-76 protocadherin 8 Homo sapiens 43-47 18757839-7 2009 Supporting this hypothesis, cotreatment of cells with exogenous NAD(P)H and Ox-PAPC significantly decreased oxidative stress and HO-1 induction by Ox-PAPC. nad(p)h 64-71 protocadherin 8 Homo sapiens 150-154 18071189-1 2008 Oxidation products of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphatidylcholine (Ox-PAPC) are found in atherosclerotic lesions, apoptotic cells, and oxidized LDL and stimulate human aortic endothelial cells (HAECs) to produce inflammatory cytokines, leukocyte chemoattractants, and coagulation factors. 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphatidylcholine 22-81 protocadherin 8 Homo sapiens 86-90 18071189-3 2008 To characterize the HAEC proteins with which oxidized phospholipids interact, a biotinylated PAPC analog, 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphatidyl-(N-biotinylethanolamine) (PAPE-N-biotin), was synthesized. 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphatidyl-(n-biotinylethanolamine 106-182 protocadherin 8 Homo sapiens 93-97 18071189-4 2008 Oxidation of PAPE-N-biotin in air generated a mixture of biotin-labeled oxidized lipids analogous to Ox-PAPC. PAPE-N-biotin 13-26 protocadherin 8 Homo sapiens 104-108 18071189-4 2008 Oxidation of PAPE-N-biotin in air generated a mixture of biotin-labeled oxidized lipids analogous to Ox-PAPC. Biotin 20-26 protocadherin 8 Homo sapiens 104-108 18071189-5 2008 Ox-PAPE-N-biotin, like Ox-PAPC, induced interleukin-8 (IL-8) protein synthesis and stimulated IL-8, low density lipoprotein receptor, heme oxygenase-1, and activating transcription factor-3 mRNA expression in HAECs. n-biotin 8-16 protocadherin 8 Homo sapiens 26-30 17726017-1 2007 Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC) and its component phospholipid, 1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine, induce endothelial cells (EC) to synthesize chemotactic factors, such as interleukin 8 (IL-8). 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine 9-66 protocadherin 8 Homo sapiens 71-75 17726017-1 2007 Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC) and its component phospholipid, 1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine, induce endothelial cells (EC) to synthesize chemotactic factors, such as interleukin 8 (IL-8). Phospholipids 95-107 protocadherin 8 Homo sapiens 71-75 17726017-1 2007 Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC) and its component phospholipid, 1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine, induce endothelial cells (EC) to synthesize chemotactic factors, such as interleukin 8 (IL-8). 1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine 109-170 protocadherin 8 Homo sapiens 71-75 16497987-1 2006 Oxidized-1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (Ox-PAPC), found in atherosclerotic lesions and other sites of chronic inflammation, activates endothelial cells (EC) to synthesize chemotactic factors, such as interleukin (IL)-8. 1-palmitoyl-2-arachidonyl-3-phosphorylcholine 9-65 protocadherin 8 Homo sapiens 70-74 16497987-4 2006 Ox-PAPC treatment of EC induced a dose- and time-dependent activation of eNOS, as measured by phosphorylation of serine 1177, dephosphorylation of threonine 495, and the conversion of L-arginine to L-citrulline. Serine 113-119 protocadherin 8 Homo sapiens 3-7 16497987-4 2006 Ox-PAPC treatment of EC induced a dose- and time-dependent activation of eNOS, as measured by phosphorylation of serine 1177, dephosphorylation of threonine 495, and the conversion of L-arginine to L-citrulline. Threonine 147-156 protocadherin 8 Homo sapiens 3-7 16497987-4 2006 Ox-PAPC treatment of EC induced a dose- and time-dependent activation of eNOS, as measured by phosphorylation of serine 1177, dephosphorylation of threonine 495, and the conversion of L-arginine to L-citrulline. Arginine 184-194 protocadherin 8 Homo sapiens 3-7 16497987-4 2006 Ox-PAPC treatment of EC induced a dose- and time-dependent activation of eNOS, as measured by phosphorylation of serine 1177, dephosphorylation of threonine 495, and the conversion of L-arginine to L-citrulline. Citrulline 198-210 protocadherin 8 Homo sapiens 3-7 16497987-6 2006 These studies also demonstrated that pretreatment of EC with NOS inhibitor, Nomega-nitro-L-arginine-methyl ester (L-NAME), significantly inhibited Ox-PAPC-induced IL-8 synthesis. NG-Nitroarginine Methyl Ester 76-112 protocadherin 8 Homo sapiens 150-154 16497987-6 2006 These studies also demonstrated that pretreatment of EC with NOS inhibitor, Nomega-nitro-L-arginine-methyl ester (L-NAME), significantly inhibited Ox-PAPC-induced IL-8 synthesis. NG-Nitroarginine Methyl Ester 114-120 protocadherin 8 Homo sapiens 150-154 16497987-8 2006 Our data demonstrated that Ox-PAPC-induced SREBP activation and expression of SREBP target genes were significantly reduced by pretreatment with L-NAME. NG-Nitroarginine Methyl Ester 145-151 protocadherin 8 Homo sapiens 30-34 16497987-10 2006 Rather, our findings indicated that superoxide (O2*-), in combination with NO, regulated SREBP activation by Ox-PAPC. Superoxides 36-46 protocadherin 8 Homo sapiens 112-116 16497987-10 2006 Rather, our findings indicated that superoxide (O2*-), in combination with NO, regulated SREBP activation by Ox-PAPC. Superoxides 48-52 protocadherin 8 Homo sapiens 112-116 16497987-11 2006 We found that Ox-PAPC treatment generated O2*- through an eNOS-mediated mechanism and that mercaptoethylguanidine, a peroxynitrite scavenger, reduced SREBP activation by Ox-PAPC. Superoxides 42-44 protocadherin 8 Homo sapiens 17-21 16497987-11 2006 We found that Ox-PAPC treatment generated O2*- through an eNOS-mediated mechanism and that mercaptoethylguanidine, a peroxynitrite scavenger, reduced SREBP activation by Ox-PAPC. 2-mercaptoethylguanidine 91-113 protocadherin 8 Homo sapiens 173-177 16497987-11 2006 We found that Ox-PAPC treatment generated O2*- through an eNOS-mediated mechanism and that mercaptoethylguanidine, a peroxynitrite scavenger, reduced SREBP activation by Ox-PAPC. Peroxynitrous Acid 117-130 protocadherin 8 Homo sapiens 173-177 15143062-4 2004 Ox-PAPC and its component phospholipids induced a rapid and transient phosphorylation of c-src Tyr418, a hallmark of c-src activation, in human aortic endothelial cells (HAEC). Phospholipids 26-39 protocadherin 8 Homo sapiens 3-7 15242861-1 2004 OBJECTIVE: Mitogen-activated protein kinase phosphatase-1 (MKP-1) is one of several oxidized-l-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC)-induced genes identified in human aortic endothelial cells (HAEC). -l-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine 92-158 protocadherin 8 Homo sapiens 163-167 14622025-8 2003 For HL the V(max) of phospholipid hydrolysis for (POPC)rHDL > (PLPC)rHDL approximately (PDPC)rHDL > (PAPC)rHDL, while the K(m)(app) for (POPC)rHDL > (PDPC)rHDL > (PLPC)rHDL > (PAPC)rHDL. Phospholipids 21-33 protocadherin 8 Homo sapiens 107-111 14709399-4 2004 Our results demonstrate that OxPAPC treatment activated in a time-dependent fashion protein kinase C (PKC), protein kinase A (PKA), Raf/MEK1,2/Erk-1,2 MAP kinase cascade, JNK MAP kinase and transient protein tyrosine phosphorylation in human pulmonary artery endothelial cells (HPAEC), whereas nonoxidized PAPC was without effect. Tyrosine 208-216 protocadherin 8 Homo sapiens 31-35 15517554-1 2004 Lineloyl-palmitoyl (PLPC) and arachidonoyl-palmitoyl (PAPC) phosphatidylcholine were oxidized under Fenton reaction conditions (H2O2 and Fe2+), and the short-chain products formed were identified by electrospray ionization mass spectrometry (ESI-MS). arachidonoyl-palmitoyl 30-52 protocadherin 8 Homo sapiens 54-58 15517554-1 2004 Lineloyl-palmitoyl (PLPC) and arachidonoyl-palmitoyl (PAPC) phosphatidylcholine were oxidized under Fenton reaction conditions (H2O2 and Fe2+), and the short-chain products formed were identified by electrospray ionization mass spectrometry (ESI-MS). Phosphatidylcholines 60-79 protocadherin 8 Homo sapiens 54-58 15517554-1 2004 Lineloyl-palmitoyl (PLPC) and arachidonoyl-palmitoyl (PAPC) phosphatidylcholine were oxidized under Fenton reaction conditions (H2O2 and Fe2+), and the short-chain products formed were identified by electrospray ionization mass spectrometry (ESI-MS). Hydrogen Peroxide 128-132 protocadherin 8 Homo sapiens 54-58 15517554-1 2004 Lineloyl-palmitoyl (PLPC) and arachidonoyl-palmitoyl (PAPC) phosphatidylcholine were oxidized under Fenton reaction conditions (H2O2 and Fe2+), and the short-chain products formed were identified by electrospray ionization mass spectrometry (ESI-MS). ammonium ferrous sulfate 137-141 protocadherin 8 Homo sapiens 54-58 14622025-8 2003 For HL the V(max) of phospholipid hydrolysis for (POPC)rHDL > (PLPC)rHDL approximately (PDPC)rHDL > (PAPC)rHDL, while the K(m)(app) for (POPC)rHDL > (PDPC)rHDL > (PLPC)rHDL > (PAPC)rHDL. Phospholipids 21-33 protocadherin 8 Homo sapiens 191-195 12775576-1 2003 OBJECTIVE: We have previously shown that phospholipid oxidation products of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (ox-PAPC) inhibit lipopolysaccharide (LPS)-induced E-selectin expression and neutrophil binding in human aortic endothelial cells (HAECs). Phospholipids 41-53 protocadherin 8 Homo sapiens 138-142 12775576-1 2003 OBJECTIVE: We have previously shown that phospholipid oxidation products of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (ox-PAPC) inhibit lipopolysaccharide (LPS)-induced E-selectin expression and neutrophil binding in human aortic endothelial cells (HAECs). 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine 76-133 protocadherin 8 Homo sapiens 138-142 12576329-3 2003 Oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphocholine (ox-PAPC), but not native PAPC or a reduced form of ox-PAPC, markedly decreased TM mRNA levels. PC(16:0/20:0) 9-62 protocadherin 8 Homo sapiens 67-71 12100999-4 2002 We show that 1-palmitoyl, 2-(11,15 dihydroxy) eicosatrienoyl PC (diOH-PAPC) caused less of an increase in the temperature of the lamellar to hexagonal II transition (T(H)) of an unsaturated PE, compared to its parent, PAPC. 1-palmitoyl 13-24 protocadherin 8 Homo sapiens 70-74 12100999-4 2002 We show that 1-palmitoyl, 2-(11,15 dihydroxy) eicosatrienoyl PC (diOH-PAPC) caused less of an increase in the temperature of the lamellar to hexagonal II transition (T(H)) of an unsaturated PE, compared to its parent, PAPC. 1-palmitoyl 13-24 protocadherin 8 Homo sapiens 218-222 12100999-4 2002 We show that 1-palmitoyl, 2-(11,15 dihydroxy) eicosatrienoyl PC (diOH-PAPC) caused less of an increase in the temperature of the lamellar to hexagonal II transition (T(H)) of an unsaturated PE, compared to its parent, PAPC. 2-(11,15 dihydroxy) eicosatrienoyl pc 26-63 protocadherin 8 Homo sapiens 70-74 12100999-4 2002 We show that 1-palmitoyl, 2-(11,15 dihydroxy) eicosatrienoyl PC (diOH-PAPC) caused less of an increase in the temperature of the lamellar to hexagonal II transition (T(H)) of an unsaturated PE, compared to its parent, PAPC. 2-(11,15 dihydroxy) eicosatrienoyl pc 26-63 protocadherin 8 Homo sapiens 218-222 12100999-6 2002 We found that whereas diOH-PAPC activates CT, it inhibits PKC relative to the parent PAPC. ct 42-44 protocadherin 8 Homo sapiens 27-31 12449017-1 2002 Oxidized-L-alpha-1-Palmitoyl-2-Arachidonoyl-sn-glycero-3-Phosphorylcholine (Ox-PAPC), a component of mildly oxidized/minimally modified low-density lipoprotein (MM-LDL), accounts for many of the biological activities of MM-LDL. -l-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine 8-74 protocadherin 8 Homo sapiens 79-83 12123780-4 2002 METHODS: Macrophages were incubated with a mixture of oxidized fragmented phospholipids (ox-PAPC), present in modified LDL, and then exposed to LPS. Phospholipids 74-87 protocadherin 8 Homo sapiens 92-96 12324237-7 2002 Among lipid constituents of oxLDLs, Ox-PAPC, a mixture of oxidized arachidonic acid-containing phospholipids, prevents Cox-2 expression, suggesting that it could be considered responsible for the biological activity of oxLDLs. Arachidonic Acid 67-83 protocadherin 8 Homo sapiens 39-43 12324237-7 2002 Among lipid constituents of oxLDLs, Ox-PAPC, a mixture of oxidized arachidonic acid-containing phospholipids, prevents Cox-2 expression, suggesting that it could be considered responsible for the biological activity of oxLDLs. Phospholipids 95-108 protocadherin 8 Homo sapiens 39-43 9315860-10 1997 The hydrolysis of different species of PC [dipalmitoyl (DPPC), dioleoyl(DOPC), palmitoylarachidonoyl (PAPC), and palmitoyloleoyl (POPC)] in r-HDL was also investigated. Phosphatidylcholines 39-41 protocadherin 8 Homo sapiens 102-106 11597930-1 2001 Oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (Ox-PAPC) upregulates a spectrum of inflammatory cytokines and adhesion molecules different from those induced by classic inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha) or lipopolysaccharide. 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine 9-66 protocadherin 8 Homo sapiens 71-75 11597930-7 2001 Actinomycin D experiments suggested that both Ox-PAPC and TNF-alpha regulate the expression of IL-8 at the transcriptional level. Dactinomycin 0-13 protocadherin 8 Homo sapiens 49-53 11278958-7 2001 Inhibition of MKP-1 using either the phosphatase inhibitor sodium orthovanadate or antisense oligonucleotides prevents the accumulation of monocyte chemotactic activity in ox-PAPC-treated HAEC supernatants. Sodium orthovanadate 59-79 protocadherin 8 Homo sapiens 175-179 11278958-7 2001 Inhibition of MKP-1 using either the phosphatase inhibitor sodium orthovanadate or antisense oligonucleotides prevents the accumulation of monocyte chemotactic activity in ox-PAPC-treated HAEC supernatants. Oligonucleotides 93-109 protocadherin 8 Homo sapiens 175-179 9315860-11 1997 In discoidal r-HDL, we found that POPC >/= DOPC = PAPC/DPPC. 1,2-oleoylphosphatidylcholine 46-50 protocadherin 8 Homo sapiens 53-57 9315860-12 1997 However, in LCAT-treated spheroidal r-HDL, POPC = DOPC > PAPC/DPPC. 1,2-oleoylphosphatidylcholine 50-54 protocadherin 8 Homo sapiens 60-64 9108780-5 1997 Similar to MM-LDL, oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (ox-PAPC) and the isoprostane 8-iso prostaglandin E2 but not PAPC or isoprostane 8-iso prostaglandin F2 alpha induced alkaline phosphatase activity and differentiation of CVCs. 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine 28-85 protocadherin 8 Homo sapiens 90-94 34576831-4 2021 Mature PAPC-4104 is 282 amino acids long, preceded by the 101-amino acid propeptide necessary for proper folding and maturation. propeptide 73-83 protocadherin 8 Homo sapiens 7-11