PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
23985323-4	2013	We identify the SH3 domains of nebulin and nebulette as novel ligands of proline-rich regions of Xin and XIRP2.	Proline	73-80	nebulin	Homo sapiens	31-38
27451206-4	2016	The catalytic ability of nitrosylated mu-calpain to degrade titin, nebulin, troponin-T and desmin was significantly reduced when the GSNO concentration was higher than 300muM.	S-Nitrosoglutathione	133-137	nebulin	Homo sapiens	67-74
25938837-8	2015	Using exome-sequencing analysis, a possibly damaging, non-synonymous variant in the gene Nebulin (NEB) was found to segregate with PACG which alters a phylogenetically conserved Lysine residue.	Lysine	178-184	nebulin	Homo sapiens	89-96
25110572-8	2014	We also used the GST pull-down assay to test the affinity of WT nebulin super repeats for WT alpha- and beta-tropomyosin, and for beta-tropomyosin with six patient mutations: p.Lys7del, p.Glu41Lys, p.Lys49del, p.Glu117Lys, p.Glu139del and p.Gln147Pro.	alpha- and beta-tropomyosin	93-120	nebulin	Homo sapiens	64-71
25110572-8	2014	We also used the GST pull-down assay to test the affinity of WT nebulin super repeats for WT alpha- and beta-tropomyosin, and for beta-tropomyosin with six patient mutations: p.Lys7del, p.Glu41Lys, p.Lys49del, p.Glu117Lys, p.Glu139del and p.Gln147Pro.	lys7del	177-184	nebulin	Homo sapiens	64-71
12482578-2	2002	We have investigated the binding of nebulin SH3 with proline-rich peptides derived from the 28-mer PEVK modules of titin and the Z-line protein myopalladin, using fluorescence, circular dichroism and nuclear magnetic resonance techniques.	Proline	53-60	nebulin	Homo sapiens	36-43
17177073-7	2007	The serine-rich linker region of nebulette has previously been shown to serve just such a purpose by targeting the association of the nebulin modules to the cardiac Z-line in cultured cardiomyocytes.	Serine	4-10	nebulin	Homo sapiens	134-141
14714525-9	2003	Presumably, the complex effect of phalloidin in skeletal muscle is related to the disturbance of the actin-nebulin interaction, which may help to clarify the role of nebulin in the regulation contraction.	Phalloidine	34-44	nebulin	Homo sapiens	107-114
14714525-9	2003	Presumably, the complex effect of phalloidin in skeletal muscle is related to the disturbance of the actin-nebulin interaction, which may help to clarify the role of nebulin in the regulation contraction.	Phalloidine	34-44	nebulin	Homo sapiens	166-173
19346529-4	2009	SDS-PAGE and western blotting revealed greatly reduced nebulin levels in skeletal muscle of NM-NEB patients, with the most prominent reduction at nebulin"s N-terminal end.	Sodium Dodecyl Sulfate	0-3	nebulin	Homo sapiens	55-62
16902413-8	2006	The myopathic changes in the nebulin KO model include depressed contractility, loss of myopalladin from the Z-disk, and dysregulation of genes involved in calcium homeostasis and glycogen metabolism; features potentially relevant for understanding human NM.	Calcium	155-162	nebulin	Homo sapiens	29-36
16902413-8	2006	The myopathic changes in the nebulin KO model include depressed contractility, loss of myopalladin from the Z-disk, and dysregulation of genes involved in calcium homeostasis and glycogen metabolism; features potentially relevant for understanding human NM.	Glycogen	179-187	nebulin	Homo sapiens	29-36
8609630-10	1996	Analysis of the influence of charged media as well as trifluoroethanol on the folding of single repeats strongly suggested that the mechanism by which the nebulin alpha-helix is stabilised is mostly electrostatic.	Trifluoroethanol	54-70	nebulin	Homo sapiens	155-162
9648223-2	1998	Calpastatin domain I at 0.1 mM bound to connectin and nebulin filaments, and deteriorated their physico-chemical properties; the calcium-binding ability of connectin and nebulin filaments was suppressed, the susceptibility of both filaments to trypsin was markedly decreased, and the resting tension of mechanically skinned fibers was increased by 2.5 times that of the control at a sarcomere length of 3.6 microns.	Calcium	129-136	nebulin	Homo sapiens	170-177
9583363-1	1998	We have investigated the interaction of a 6-repeat recombinant human nebulin fragment (S6R2R7) with F-actin, with Mg2+-induced actin paracrystals, and G-actin, respectively.	magnesium ion	114-118	nebulin	Homo sapiens	69-76
9583363-7	1998	The bundles were also visible in the light microscope, and immunofluorescence microscopy revealed binding of the nebulin fragment S6R2R7 to both preformed Mg2+ paracrystals and to F-actin.	magnesium ion	155-159	nebulin	Homo sapiens	113-120
9733644-5	1998	The C-terminal regions of nebulin and nebulette are identical in domain organization and share a family of highly related C-terminal repeats, a serine-rich domain with potential phosphorylation sites, and an SH3 domain.	Serine	144-150	nebulin	Homo sapiens	26-33
7918483-9	1994	Calmodulin with calcium greatly reduces the binding of nebulin fragments to both actin and myosin.	Calcium	16-23	nebulin	Homo sapiens	55-62
7710083-0	1995	Detection of giant myofibrillar proteins connectin and nebulin by electrophoresis in 2% polyacrylamide slab gels strengthened with agarose.	polyacrylamide	88-102	nebulin	Homo sapiens	55-62
7710083-0	1995	Detection of giant myofibrillar proteins connectin and nebulin by electrophoresis in 2% polyacrylamide slab gels strengthened with agarose.	Sepharose	131-138	nebulin	Homo sapiens	55-62
8816284-12	1996	In cultures treated with the microtubule stabilizing drug taxol, the amount of stress fibers and nascent I-bands was greatly diminished as previously reported by others; however, nebulin was found associated with myofibrils in a mature striated distribution.	Paclitaxel	58-63	nebulin	Homo sapiens	179-186
8586652-3	1995	These results indicate that nebulin inhibits rhodamine-phalloidin binding to actin and suggests that the unidirectional rhodamine-phalloidin binding may be due to cooperative competitive binding, i.e. phalloidin "unzips" nebulin starting from the pointed ends of the thin filaments.	rhodamine-phalloidin	45-65	nebulin	Homo sapiens	28-35
8586652-3	1995	These results indicate that nebulin inhibits rhodamine-phalloidin binding to actin and suggests that the unidirectional rhodamine-phalloidin binding may be due to cooperative competitive binding, i.e. phalloidin "unzips" nebulin starting from the pointed ends of the thin filaments.	Rhodamines	45-54	nebulin	Homo sapiens	28-35
8586652-3	1995	These results indicate that nebulin inhibits rhodamine-phalloidin binding to actin and suggests that the unidirectional rhodamine-phalloidin binding may be due to cooperative competitive binding, i.e. phalloidin "unzips" nebulin starting from the pointed ends of the thin filaments.	Phalloidine	55-65	nebulin	Homo sapiens	28-35
8586652-3	1995	These results indicate that nebulin inhibits rhodamine-phalloidin binding to actin and suggests that the unidirectional rhodamine-phalloidin binding may be due to cooperative competitive binding, i.e. phalloidin "unzips" nebulin starting from the pointed ends of the thin filaments.	Phalloidine	130-140	nebulin	Homo sapiens	28-35
7710083-1	1995	We have established an improved method of sodium dodecyl sulfate-polyacrylamide gel electrophoresis to facilitate analysis of giant myofibrillar proteins connectin and nebulin, whose molecular masses are about 3000 and 700 kDa, respectively.	Sodium Dodecyl Sulfate	42-64	nebulin	Homo sapiens	168-175
7710083-1	1995	We have established an improved method of sodium dodecyl sulfate-polyacrylamide gel electrophoresis to facilitate analysis of giant myofibrillar proteins connectin and nebulin, whose molecular masses are about 3000 and 700 kDa, respectively.	polyacrylamide	65-79	nebulin	Homo sapiens	168-175
1295887-0	1992	Purification and characterization of nebulin subfragments produced by 0.1 mM CaCl2.	Calcium Chloride	77-82	nebulin	Homo sapiens	37-44
1295887-1	1992	Nebulin, which forms a long inextensible filament in sarcomeres, was fragmented into 200-, 180-, 40-, 33-, and 23-kDa subfragments on treatment with 0.1 mM CaCl2.	Calcium Chloride	156-161	nebulin	Homo sapiens	0-7
1295887-6	1992	We have developed a new "fluorescence-method" to detect the binding of calcium ions to a protein using quin2, and clarified that nebulin is a calcium-binding protein, and that calcium ions bind to the 200-, 40-, and 23-kDa subfragments.	Calcium	71-78	nebulin	Homo sapiens	129-136
1295887-6	1992	We have developed a new "fluorescence-method" to detect the binding of calcium ions to a protein using quin2, and clarified that nebulin is a calcium-binding protein, and that calcium ions bind to the 200-, 40-, and 23-kDa subfragments.	Calcium	142-149	nebulin	Homo sapiens	129-136
1295887-6	1992	We have developed a new "fluorescence-method" to detect the binding of calcium ions to a protein using quin2, and clarified that nebulin is a calcium-binding protein, and that calcium ions bind to the 200-, 40-, and 23-kDa subfragments.	Calcium	142-149	nebulin	Homo sapiens	129-136
1295887-7	1992	Nebulin filaments are probably fragmented on the binding of large amounts of calcium ions to the 200-, 40-, and 23-kDa subfragments.	Calcium	77-84	nebulin	Homo sapiens	0-7
31982973-4	2020	Secondly, we reviewed nebulin"s involvement in the regulation of muscle contraction, cross-bridge cycling kinetics, Ca2+-homeostasis and excitation contraction (EC) coupling.	Calcium	116-120	nebulin	Homo sapiens	22-29
33618464-4	2020	We reported that not only PM2.5-0.3, but also, to a lesser extent, its inorganic chemical fraction, NEM2.5-0.3, and organic chemical fraction, OEM2.5-0.3, were able to significantly induce ROS overproduction and oxidative damage notwithstanding the early activation of NRF2 signaling pathway.	ros	189-192	nebulin	Homo sapiens	100-104
32278794-6	2020	We found that expression of DCDC2, ANKRD18B, ALDH1A1, c14orf105, ITGBL1 and NEB was overexpressed in taxol-resistant cells, suggesting the involvement of these AR-related genes in taxol resistance.	Paclitaxel	101-106	nebulin	Homo sapiens	76-79
34211429-0	2021	A Homozygous Deep Intronic Mutation Alters the Splicing of Nebulin Gene in a Patient With Nemaline Myopathy.	nemaline	90-98	nebulin	Homo sapiens	59-66
33142923-5	2020	Oxidation of sulfhydryl (SH) groups was detected in structural proteins (e.g., nebulin, alpha-actinin, meromyosin 2) and in contractile proteins (e.g., myosin heavy chain and myosin-binding protein C) as well as in titin in the presence of 300 microM heme.	Sulfhydryl Compounds	13-23	nebulin	Homo sapiens	79-86
33142923-5	2020	Oxidation of sulfhydryl (SH) groups was detected in structural proteins (e.g., nebulin, alpha-actinin, meromyosin 2) and in contractile proteins (e.g., myosin heavy chain and myosin-binding protein C) as well as in titin in the presence of 300 microM heme.	Sulfhydryl Compounds	25-27	nebulin	Homo sapiens	79-86
33142923-7	2020	Sulfenic acid (SOH) formation was also detected in the structural proteins (nebulin, alpha-actinin, meromyosin).	Sulfenic Acids	0-13	nebulin	Homo sapiens	76-83
33142923-7	2020	Sulfenic acid (SOH) formation was also detected in the structural proteins (nebulin, alpha-actinin, meromyosin).	SOH	15-18	nebulin	Homo sapiens	76-83
32939402-5	2020	She harbored two variants in the nebulin gene, c.20131C > T (p.Arg6711Trp) and c.674C > T (p.Pro225Leu), and one of them, c.674C > T, was a novel variant.	arg6711trp	63-73	nebulin	Homo sapiens	33-40
30948421-0	2019	Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity.	Calcium	69-76	nebulin	Homo sapiens	0-7
30356055-2	2018	Mutations in the nebulin gene NEB are a common cause of nemaline myopathy.	nemaline	56-64	nebulin	Homo sapiens	17-24