PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
20657013-10	2010	Our results show that betaklotho not only interacts with heparan sulfate-FGFR4 to form a complex with high affinity for endocrine FGF19 but also impacts the quality of downstream signaling and biological end points activated by either FGF19 or canonical FGF1.	heparan	57-64	klotho beta	Homo sapiens	22-32
21653700-0	2011	Sulfated glycosaminoglycans are required for specific and sensitive fibroblast growth factor (FGF) 19 signaling via FGF receptor 4 and betaKlotho.	Glycosaminoglycans	9-27	klotho beta	Homo sapiens	135-145
17711860-5	2007	In addition, heparin further enhanced the effects of both alphaKlotho and betaKlotho in FGF19 signaling and interaction experiments.	Heparin	13-20	klotho beta	Homo sapiens	74-84
19117008-5	2009	In order to investigate their role in the activity of FGF21, we have constructed a series of deletion mutants and tested them for their ability to (1) bind betaKlotho, analyzed by surface plasmon resonance spectroscopy (2) signal through MAPK phosphorylation and inhibit apoptosis in 3T3-L1/betaKlotho fibroblasts (3) stimulate GLUT1 mRNA upregulation and glucose uptake in 3T3-L1 adipocytes.	Glucose	356-363	klotho beta	Homo sapiens	156-166
34751982-3	2022	Mechanism(s) leading to increased hepatic synthesis and colonic bile acid levels in "idiopathic" BAD include reduced synthesis of FGF-19 by the ileal mucosa, or genetic variation in hepatocyte proteins klotho beta and FGF receptor 4 (FGFR4) that mediate negative feedback of bile acid synthesis.	Bile Acids and Salts	275-284	klotho beta	Homo sapiens	202-213
16374861-0	2006	BetaKlotho: a new kid on the bile acid biosynthesis block.	Bile Acids and Salts	29-38	klotho beta	Homo sapiens	0-10
17339340-7	2007	Klotho/betaKlotho have evolved as a compensatory mechanism for the poor ability of heparin/heparan sulfate to promote binding of FGF19, -21, and -23 to their cognate receptors.	Heparin	83-90	klotho beta	Homo sapiens	7-17
17339340-7	2007	Klotho/betaKlotho have evolved as a compensatory mechanism for the poor ability of heparin/heparan sulfate to promote binding of FGF19, -21, and -23 to their cognate receptors.	Heparitin Sulfate	91-106	klotho beta	Homo sapiens	7-17
17373502-7	2007	A new PAH partitioning model, Kd = KLB-C(1 - ftar)alpha + ftarKtar (alpha = empirical exponent), incorporates these effects in which the control of PAH partitioning transits from being dominated by sorption in lampblack (KLB-C) to absorption in oil tar (Ktar), depending on the fraction of tar (ftar).	Polycyclic Aromatic Hydrocarbons	6-9	klotho beta	Homo sapiens	35-38
17373502-7	2007	A new PAH partitioning model, Kd = KLB-C(1 - ftar)alpha + ftarKtar (alpha = empirical exponent), incorporates these effects in which the control of PAH partitioning transits from being dominated by sorption in lampblack (KLB-C) to absorption in oil tar (Ktar), depending on the fraction of tar (ftar).	Polycyclic Aromatic Hydrocarbons	6-9	klotho beta	Homo sapiens	221-224
17373502-7	2007	A new PAH partitioning model, Kd = KLB-C(1 - ftar)alpha + ftarKtar (alpha = empirical exponent), incorporates these effects in which the control of PAH partitioning transits from being dominated by sorption in lampblack (KLB-C) to absorption in oil tar (Ktar), depending on the fraction of tar (ftar).	Polycyclic Aromatic Hydrocarbons	148-151	klotho beta	Homo sapiens	35-38
17373502-7	2007	A new PAH partitioning model, Kd = KLB-C(1 - ftar)alpha + ftarKtar (alpha = empirical exponent), incorporates these effects in which the control of PAH partitioning transits from being dominated by sorption in lampblack (KLB-C) to absorption in oil tar (Ktar), depending on the fraction of tar (ftar).	Polycyclic Aromatic Hydrocarbons	148-151	klotho beta	Homo sapiens	221-224
34732847-2	2022	FGF21 signaling requires co-receptor beta-klotho (KLB) co-acting with FGF receptors, which has pleiotropic metabolic effects, including induced hepatic fatty acid oxidation and ketogenesis, in human and animal models of obesity.	Fatty Acids	152-162	klotho beta	Homo sapiens	37-48
34732847-2	2022	FGF21 signaling requires co-receptor beta-klotho (KLB) co-acting with FGF receptors, which has pleiotropic metabolic effects, including induced hepatic fatty acid oxidation and ketogenesis, in human and animal models of obesity.	Fatty Acids	152-162	klotho beta	Homo sapiens	50-53
34461157-3	2021	In this study, Kraft lignin from wheat straw (KL-A) was used as the raw material to fractionate into three fractions (e.g., KL-B, KL-C, and KL-D) with different molecular weight by ultrafiltration, which possessed different physicochemical properties.	Lignin	21-27	klotho beta	Homo sapiens	124-128
31576649-9	2019	In HepG2 cells, MaR1 reverses the increased production of FGF21 and the downregulation of FGFR1, Beta-KLOTHO, EGR1, and cFOS induced by palmitate.	Palmitates	136-145	klotho beta	Homo sapiens	97-108
35620160-2	2022	It plays important roles in regulating both glucose and lipid homeostasis via interacting with a heterodimeric receptor complex comprising FGF receptor 1 (FGFR1) and beta-klotho (KLB).	Glucose	44-51	klotho beta	Homo sapiens	166-177
35620160-2	2022	It plays important roles in regulating both glucose and lipid homeostasis via interacting with a heterodimeric receptor complex comprising FGF receptor 1 (FGFR1) and beta-klotho (KLB).	Glucose	44-51	klotho beta	Homo sapiens	179-182
35108517-5	2022	Further, we reveal that FGF21 suppresses alcohol consumption through a projection-specific subpopulation of KLB-expressing neurons in the basolateral amygdala.	Alcohols	41-48	klotho beta	Homo sapiens	108-111
31655133-9	2020	In HepG2 and Huh7 hepatoma cell lines, exposure to free fatty acids caused a severe reduction of intracellular and secreted KLB.	Fatty Acids, Nonesterified	51-67	klotho beta	Homo sapiens	124-127
31255518-5	2019	The FGFR1 inhibitor PD173074 was applied to demonstrate that rhFGF21 functions through the formation of FGF21/FGFR1/beta-klotho complexes.	PD 173074	20-28	klotho beta	Homo sapiens	116-127
31535308-4	2019	The results showed that FGF21 increased glucose uptake significantly in a dose-dependent and time-dependent manner in 3T3-L1-betaKlotho cells.	Glucose	40-47	klotho beta	Homo sapiens	125-135
31535308-8	2019	Furthermore, FGF21-stimulated elevation of glucose uptake, GLUT1 mRNA transcription and the phosphorylation of ERK1/2 were dramatically attenuated by pretreatment of cells with FGFR specific inhibitor SU5402 in 3T3-L1-betaKlotho cells.	SU 5402	201-207	klotho beta	Homo sapiens	218-228
30921473-6	2019	Genetic studies have revealed that patterns of weekly candy and alcohol consumption are associated with genetic variants in FGF21 and its co-receptor beta-klotho (KLB), suggesting that liking for sugar, and fermented sugar, may be influenced by natural variation in FGF21 signal strength in humans.	Alcohols	64-71	klotho beta	Homo sapiens	150-161
30921473-6	2019	Genetic studies have revealed that patterns of weekly candy and alcohol consumption are associated with genetic variants in FGF21 and its co-receptor beta-klotho (KLB), suggesting that liking for sugar, and fermented sugar, may be influenced by natural variation in FGF21 signal strength in humans.	Alcohols	64-71	klotho beta	Homo sapiens	163-166
30921473-6	2019	Genetic studies have revealed that patterns of weekly candy and alcohol consumption are associated with genetic variants in FGF21 and its co-receptor beta-klotho (KLB), suggesting that liking for sugar, and fermented sugar, may be influenced by natural variation in FGF21 signal strength in humans.	Sugars	196-201	klotho beta	Homo sapiens	150-161
30921473-6	2019	Genetic studies have revealed that patterns of weekly candy and alcohol consumption are associated with genetic variants in FGF21 and its co-receptor beta-klotho (KLB), suggesting that liking for sugar, and fermented sugar, may be influenced by natural variation in FGF21 signal strength in humans.	Sugars	196-201	klotho beta	Homo sapiens	163-166
30317562-2	2019	However, it was found that human FGF21 loses its ability to bind to FGFR1-KLB after iodination with Na125 I and chloramine T, whereas human FGF19 retained its affinity for FGFR1-KLB even after iodination.	na125	100-105	klotho beta	Homo sapiens	74-77
30317562-4	2019	In this study, we first demonstrated that an intramolecular disulfide bond was formed between cysteine-102 and cysteine-121 in FGF21, implying that the oxidation of the cysteine to cysteic acid, which may interfere with the active conformation of FGF21, did not occur during the iodination procedures, and thus ruled out the possibility of the two conserved cysteine residues mediating the loss of FGF21 binding affinity to FGFR1-KLB upon iodination.	Cysteine	111-119	klotho beta	Homo sapiens	430-433
30317562-4	2019	In this study, we first demonstrated that an intramolecular disulfide bond was formed between cysteine-102 and cysteine-121 in FGF21, implying that the oxidation of the cysteine to cysteic acid, which may interfere with the active conformation of FGF21, did not occur during the iodination procedures, and thus ruled out the possibility of the two conserved cysteine residues mediating the loss of FGF21 binding affinity to FGFR1-KLB upon iodination.	Cysteine	111-119	klotho beta	Homo sapiens	430-433
30317562-4	2019	In this study, we first demonstrated that an intramolecular disulfide bond was formed between cysteine-102 and cysteine-121 in FGF21, implying that the oxidation of the cysteine to cysteic acid, which may interfere with the active conformation of FGF21, did not occur during the iodination procedures, and thus ruled out the possibility of the two conserved cysteine residues mediating the loss of FGF21 binding affinity to FGFR1-KLB upon iodination.	Cysteic Acid	181-193	klotho beta	Homo sapiens	430-433
30317562-4	2019	In this study, we first demonstrated that an intramolecular disulfide bond was formed between cysteine-102 and cysteine-121 in FGF21, implying that the oxidation of the cysteine to cysteic acid, which may interfere with the active conformation of FGF21, did not occur during the iodination procedures, and thus ruled out the possibility of the two conserved cysteine residues mediating the loss of FGF21 binding affinity to FGFR1-KLB upon iodination.	Cysteine	111-119	klotho beta	Homo sapiens	430-433
30317562-2	2019	However, it was found that human FGF21 loses its ability to bind to FGFR1-KLB after iodination with Na125 I and chloramine T, whereas human FGF19 retained its affinity for FGFR1-KLB even after iodination.	chloramine-T	112-124	klotho beta	Homo sapiens	74-77
30317562-4	2019	In this study, we first demonstrated that an intramolecular disulfide bond was formed between cysteine-102 and cysteine-121 in FGF21, implying that the oxidation of the cysteine to cysteic acid, which may interfere with the active conformation of FGF21, did not occur during the iodination procedures, and thus ruled out the possibility of the two conserved cysteine residues mediating the loss of FGF21 binding affinity to FGFR1-KLB upon iodination.	Disulfides	60-69	klotho beta	Homo sapiens	430-433
30317562-4	2019	In this study, we first demonstrated that an intramolecular disulfide bond was formed between cysteine-102 and cysteine-121 in FGF21, implying that the oxidation of the cysteine to cysteic acid, which may interfere with the active conformation of FGF21, did not occur during the iodination procedures, and thus ruled out the possibility of the two conserved cysteine residues mediating the loss of FGF21 binding affinity to FGFR1-KLB upon iodination.	Cysteine	94-102	klotho beta	Homo sapiens	430-433
30697260-1	2019	Introduction: Fibroblast growth factor-19 (FGF-19) and its co-receptor, beta-klotho, regulate bile acid synthesis in the liver as an enterohepatic feedback mechanism.	Bile Acids and Salts	94-103	klotho beta	Homo sapiens	72-83
28988823-4	2017	In contrast, beta-Klotho in neurons is essential for both FGF19 and FGF21 to cause weight loss and lower glucose and insulin levels.	Glucose	105-112	klotho beta	Homo sapiens	13-24
30042059-6	2018	Moreover, decreases in alpha-Klotho and beta-Klotho levels in the high glucose-exposed cell culture model, which was dependent on glucose exposure time, were confirmed.	Glucose	71-78	klotho beta	Homo sapiens	40-51
30042059-6	2018	Moreover, decreases in alpha-Klotho and beta-Klotho levels in the high glucose-exposed cell culture model, which was dependent on glucose exposure time, were confirmed.	Glucose	130-137	klotho beta	Homo sapiens	40-51
30042059-8	2018	Our findings indicate that serum Klotho levels were associated with the development of T2DM, and long-term control of blood glucose will be beneficial in ameliorating changes to alpha-Klotho and beta-Klotho levels in patients with T2DM and complications.	Blood Glucose	118-131	klotho beta	Homo sapiens	195-206
29661866-8	2018	In human hepatocytes and adipocytes, known target cells of FGF21 action, efavirenz, elvitegravir, and the lopinavir-ritonavir combination exerted inhibitory effects on KLB gene expression.	efavirenz	73-82	klotho beta	Homo sapiens	168-171
29661866-8	2018	In human hepatocytes and adipocytes, known target cells of FGF21 action, efavirenz, elvitegravir, and the lopinavir-ritonavir combination exerted inhibitory effects on KLB gene expression.	elvitegravir	84-96	klotho beta	Homo sapiens	168-171
29661866-8	2018	In human hepatocytes and adipocytes, known target cells of FGF21 action, efavirenz, elvitegravir, and the lopinavir-ritonavir combination exerted inhibitory effects on KLB gene expression.	Lopinavir	106-115	klotho beta	Homo sapiens	168-171
29661866-8	2018	In human hepatocytes and adipocytes, known target cells of FGF21 action, efavirenz, elvitegravir, and the lopinavir-ritonavir combination exerted inhibitory effects on KLB gene expression.	Ritonavir	116-125	klotho beta	Homo sapiens	168-171
30042059-5	2018	In addition, alpha-Klotho and beta-Klotho levels were negatively correlated with serum fructosamine and HbA1c but were not associated with serum glucose in the model including all participants.	Fructosamine	87-99	klotho beta	Homo sapiens	30-41
30068552-4	2018	The co-crystal structure of beta-Klotho KL1 domain in complex with 39F7 Fab revealed that the recognition of 39F7 is centered on Trp-295 of beta-Klotho in a FGF21 noncompetitive manner.	Tryptophan	129-132	klotho beta	Homo sapiens	28-39
30068552-4	2018	The co-crystal structure of beta-Klotho KL1 domain in complex with 39F7 Fab revealed that the recognition of 39F7 is centered on Trp-295 of beta-Klotho in a FGF21 noncompetitive manner.	Tryptophan	129-132	klotho beta	Homo sapiens	140-151
30038432-2	2018	In particular, FGF19 and FGF21 function through beta-Klotho to regulate glucose and lipid metabolism.	Glucose	72-79	klotho beta	Homo sapiens	48-59
30038432-4	2018	In this study, using hydrogen deuterium exchange coupled to mass spectrometry (HDX-MS), we identified regions on the beta-Klotho protein that likely participate in ligand interaction, and vice versa.	Hydrogen	21-29	klotho beta	Homo sapiens	117-128
30038432-4	2018	In this study, using hydrogen deuterium exchange coupled to mass spectrometry (HDX-MS), we identified regions on the beta-Klotho protein that likely participate in ligand interaction, and vice versa.	Deuterium	30-39	klotho beta	Homo sapiens	117-128
29627377-3	2018	Two large studies recently linked variants in the KLB locus with levels of alcohol intake in humans.	Alcohols	75-82	klotho beta	Homo sapiens	50-53
29731962-1	2018	Alpha-Klotho (KLalpha) and beta-Klotho (KLbeta) have recently been reported to correlate with cancer prognosis in some malignancies and we previously reported the association between KLalpha, KLbeta, and urothelial carcinoma of the bladder (UCB), indicating that KLbeta acts as a tumor promoter.	alpha-klotho	0-12	klotho beta	Homo sapiens	192-198
29731962-1	2018	Alpha-Klotho (KLalpha) and beta-Klotho (KLbeta) have recently been reported to correlate with cancer prognosis in some malignancies and we previously reported the association between KLalpha, KLbeta, and urothelial carcinoma of the bladder (UCB), indicating that KLbeta acts as a tumor promoter.	klalpha	183-190	klotho beta	Homo sapiens	40-46
28937693-5	2017	These include single-nucleotide polymorphisms (SNPs) in alcohol metabolizing genes (ADH1B/ADH1C/ADH5) and two loci in KLB, a gene recently associated with alcohol consumption.	Alcohols	155-162	klotho beta	Homo sapiens	118-121
28937693-11	2017	This study replicates the association between alcohol consumption and alcohol metabolizing genes and KLB, and identifies novel gene associations that should be the focus of future studies investigating the neurobiology of alcohol consumption.	Alcohols	46-53	klotho beta	Homo sapiens	101-104
28937693-11	2017	This study replicates the association between alcohol consumption and alcohol metabolizing genes and KLB, and identifies novel gene associations that should be the focus of future studies investigating the neurobiology of alcohol consumption.	Alcohols	70-77	klotho beta	Homo sapiens	101-104
28937693-11	2017	This study replicates the association between alcohol consumption and alcohol metabolizing genes and KLB, and identifies novel gene associations that should be the focus of future studies investigating the neurobiology of alcohol consumption.	Alcohols	70-77	klotho beta	Homo sapiens	101-104
27916483-7	2017	Multiple linear regression analyses revealed that alpha-Klotho and beta-Klotho levels were positively correlated with the creatinine clearance rate, and negatively correlated with the urinary albumin to creatinine ratio and randomly sampled serum levels of creatinine, blood urea nitrogen, and blood glucose.	Creatinine	122-132	klotho beta	Homo sapiens	67-78
28363871-0	2017	Impact of antibody subclass and disulfide isoform differences on the biological activity of CD200R and betaklotho agonist antibodies.	Disulfides	32-41	klotho beta	Homo sapiens	103-113
27916483-7	2017	Multiple linear regression analyses revealed that alpha-Klotho and beta-Klotho levels were positively correlated with the creatinine clearance rate, and negatively correlated with the urinary albumin to creatinine ratio and randomly sampled serum levels of creatinine, blood urea nitrogen, and blood glucose.	Creatinine	203-213	klotho beta	Homo sapiens	67-78
27916483-7	2017	Multiple linear regression analyses revealed that alpha-Klotho and beta-Klotho levels were positively correlated with the creatinine clearance rate, and negatively correlated with the urinary albumin to creatinine ratio and randomly sampled serum levels of creatinine, blood urea nitrogen, and blood glucose.	Creatinine	203-213	klotho beta	Homo sapiens	67-78
27916483-7	2017	Multiple linear regression analyses revealed that alpha-Klotho and beta-Klotho levels were positively correlated with the creatinine clearance rate, and negatively correlated with the urinary albumin to creatinine ratio and randomly sampled serum levels of creatinine, blood urea nitrogen, and blood glucose.	Urea	275-279	klotho beta	Homo sapiens	67-78
27916483-7	2017	Multiple linear regression analyses revealed that alpha-Klotho and beta-Klotho levels were positively correlated with the creatinine clearance rate, and negatively correlated with the urinary albumin to creatinine ratio and randomly sampled serum levels of creatinine, blood urea nitrogen, and blood glucose.	Nitrogen	280-288	klotho beta	Homo sapiens	67-78
27916483-7	2017	Multiple linear regression analyses revealed that alpha-Klotho and beta-Klotho levels were positively correlated with the creatinine clearance rate, and negatively correlated with the urinary albumin to creatinine ratio and randomly sampled serum levels of creatinine, blood urea nitrogen, and blood glucose.	Glucose	300-307	klotho beta	Homo sapiens	67-78
27911795-0	2016	KLB is associated with alcohol drinking, and its gene product beta-Klotho is necessary for FGF21 regulation of alcohol preference.	Alcohols	23-30	klotho beta	Homo sapiens	0-3
28249259-6	2017	The fibroblast growth factor 15/19 (FGF15/19), FGF receptor 4 (FGFR4) and beta-Klotho (KLB) correceptor signaling system, a key regulator of bile acids (BA) synthesis and intermediary metabolism, is emerging as an important player in hepatocarcinogenesis.	Bile Acids and Salts	141-151	klotho beta	Homo sapiens	74-103
28249259-6	2017	The fibroblast growth factor 15/19 (FGF15/19), FGF receptor 4 (FGFR4) and beta-Klotho (KLB) correceptor signaling system, a key regulator of bile acids (BA) synthesis and intermediary metabolism, is emerging as an important player in hepatocarcinogenesis.	Bile Acids and Salts	153-155	klotho beta	Homo sapiens	74-103
27911795-0	2016	KLB is associated with alcohol drinking, and its gene product beta-Klotho is necessary for FGF21 regulation of alcohol preference.	Alcohols	111-118	klotho beta	Homo sapiens	0-3
27911795-0	2016	KLB is associated with alcohol drinking, and its gene product beta-Klotho is necessary for FGF21 regulation of alcohol preference.	Alcohols	111-118	klotho beta	Homo sapiens	62-73
27911795-3	2016	We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified beta-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 x 10-12).	Alcohols	185-192	klotho beta	Homo sapiens	140-151
27911795-3	2016	We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified beta-Klotho (KLB) as a locus associated with alcohol consumption (rs11940694; P = 9.2 x 10-12).	Alcohols	185-192	klotho beta	Homo sapiens	153-156
26824324-0	2016	Metformin inhibits 17beta-estradiol-induced epithelial-to-mesenchymal transition via betaKlotho-related ERK1/2 signaling and AMPKalpha signaling in endometrial adenocarcinoma cells.	Metformin	0-9	klotho beta	Homo sapiens	85-95
26824324-0	2016	Metformin inhibits 17beta-estradiol-induced epithelial-to-mesenchymal transition via betaKlotho-related ERK1/2 signaling and AMPKalpha signaling in endometrial adenocarcinoma cells.	Estradiol	19-35	klotho beta	Homo sapiens	85-95
26824324-5	2016	In addition, metformin increased the expression of betaKlotho, a fibroblast growth factors (FGFs) coreceptor, and decreased ERK1/2 phosphorylation in both Ishikawa and KLE cells.	Metformin	13-22	klotho beta	Homo sapiens	51-61
26824324-6	2016	Decreased expression of betaKlotho was noted in human endometrial adenocarcinomas, and plasmid-driven expression of betaKlotho in Ishikawa cells abolished 17beta-estradiol-induced EMT via inhibiting ERK1/2 signaling.	Estradiol	155-171	klotho beta	Homo sapiens	116-126
26824324-9	2016	In conclusion, metformin abolishes 17beta-estradiol-induced cell proliferation and EMT in endometrial adenocarcinoma cells by upregulating betaKlotho expression, inhibiting ERK1/2 signaling, and activating AMPKalpha signaling.	Metformin	15-24	klotho beta	Homo sapiens	139-149
26824324-9	2016	In conclusion, metformin abolishes 17beta-estradiol-induced cell proliferation and EMT in endometrial adenocarcinoma cells by upregulating betaKlotho expression, inhibiting ERK1/2 signaling, and activating AMPKalpha signaling.	Estradiol	35-51	klotho beta	Homo sapiens	139-149
25012842-7	2014	Faster CT48 observed with both CC and TT GPBAR1 genotypes was due to significant interaction with G allele of KLB, which increases BA synthesis and excretion.	Bile Acids and Salts	43-45	klotho beta	Homo sapiens	110-113
27018117-3	2016	Variants in KLB and FGFR4 genes (that determine the functional re-uptake of BA in the portal circulation by hepatocytes) are also demonstrated to be associated with (75)SeHCAT retention, confirming a second potential mechanism for the development of BA diarrhea.	Bile Acids and Salts	76-78	klotho beta	Homo sapiens	12-15
27018117-3	2016	Variants in KLB and FGFR4 genes (that determine the functional re-uptake of BA in the portal circulation by hepatocytes) are also demonstrated to be associated with (75)SeHCAT retention, confirming a second potential mechanism for the development of BA diarrhea.	23-seleno-25-homotaurocholic acid	169-175	klotho beta	Homo sapiens	12-15
27018117-3	2016	Variants in KLB and FGFR4 genes (that determine the functional re-uptake of BA in the portal circulation by hepatocytes) are also demonstrated to be associated with (75)SeHCAT retention, confirming a second potential mechanism for the development of BA diarrhea.	Bile Acids and Salts	250-252	klotho beta	Homo sapiens	12-15
25070056-7	2014	Variants in genes involved in feedback regulation of BA synthesis (KLB, P=0.06 and FGFR4, P=0.09) were potentially associated with the subgroup with elevated serum C4.	Bile Acids and Salts	53-55	klotho beta	Homo sapiens	67-70
24728076-2	2014	Although it is well established that FGF19 acts through the receptor complex FGFR4-beta-Klotho (KLB) to regulate bile acid metabolism, FGF19 is also implicated in the development of HCC.	Bile Acids and Salts	113-122	klotho beta	Homo sapiens	83-94
24728076-2	2014	Although it is well established that FGF19 acts through the receptor complex FGFR4-beta-Klotho (KLB) to regulate bile acid metabolism, FGF19 is also implicated in the development of HCC.	Bile Acids and Salts	113-122	klotho beta	Homo sapiens	96-99
24200957-8	2014	Variations in KLB (rs1015450, downstream) and FGFR4 [rs434434 (intronic), rs1966265, and rs351855 (nonsynonymous)] were associated with colonic transit (rs1966265; P = 0.043), fecal bile acids (rs1015450; P = 0.064), and principal components analysis groups (all 3 FGFR4 SNVs; P < 0.05).	Bile Acids and Salts	182-192	klotho beta	Homo sapiens	14-17
24200957-10	2014	Thus exome sequencing identified additional variants in KLB and FGFR4 associated with bile acids or colonic transit in IBS-D.	Bile Acids and Salts	86-96	klotho beta	Homo sapiens	56-59
22020932-8	2011	We also found that knockdown of KLG induced another member of the Klotho family, Klotho beta (KLB).	CHEMBL2385480	32-35	klotho beta	Homo sapiens	81-92
22020932-8	2011	We also found that knockdown of KLG induced another member of the Klotho family, Klotho beta (KLB).	CHEMBL2385480	32-35	klotho beta	Homo sapiens	94-97
23923038-12	2013	The effects of Klotho coexpression and of treatment with recombinant human beta-Klotho protein were both abrogated in the presence of DSAL (10 microM).	1,2-dehydrosalsolinol	134-138	klotho beta	Homo sapiens	75-86
22271411-1	2012	BACKGROUND: Protein products of klothobeta (KLB) and fibroblast growth factor receptor 4 (FGFR4) impact fibroblast growth factor 19-mediated feedback inhibition of hepatic bile acid (BA) synthesis.	Bile Acids and Salts	172-181	klotho beta	Homo sapiens	32-42
22271411-1	2012	BACKGROUND: Protein products of klothobeta (KLB) and fibroblast growth factor receptor 4 (FGFR4) impact fibroblast growth factor 19-mediated feedback inhibition of hepatic bile acid (BA) synthesis.	Bile Acids and Salts	0-2	klotho beta	Homo sapiens	32-42