PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
32042047-5	2020	Induction of goblet cells was observed with melatonin administration, which was accompanied by suppression of Il1b and Il17a and induction of melatonin receptor and Reg3beta, an antimicrobial peptide (AMP) against Gram-negative bacteria.	Melatonin	44-53	regenerating islet-derived 3 alpha	Mus musculus	165-173
32853927-6	2020	The relation between miR-10a-3p and REG3A was tested.	mir-10a-3p	21-31	regenerating islet-derived 3 alpha	Mus musculus	36-41
32853927-11	2020	CONCLUSION: The work elucidates that miR-10a-3p restoration decreases Th17/Treg ratio and attenuates renal injury in LN via inhibiting REG3A and the activation of JAK2/STAT3 pathway, which renews the therapeutic reference for LN management.	th17	70-74	regenerating islet-derived 3 alpha	Mus musculus	135-140
32853927-11	2020	CONCLUSION: The work elucidates that miR-10a-3p restoration decreases Th17/Treg ratio and attenuates renal injury in LN via inhibiting REG3A and the activation of JAK2/STAT3 pathway, which renews the therapeutic reference for LN management.	treg	75-79	regenerating islet-derived 3 alpha	Mus musculus	135-140
33027970-10	2020	The comprehensive analysis revealed a 73-fold increase in Reg3G expression level in the PG-LPS group when compared with the control group; in addition, the expression level of Reg3A was increased by 11-fold in the PG-LPS group.	pg-lps	88-94	regenerating islet-derived 3 alpha	Mus musculus	176-181
33027970-11	2020	Image analysis showed that the ratio of Reg3A/G positive cells was higher in the PG-LPS group than the control.	pg-lps	81-87	regenerating islet-derived 3 alpha	Mus musculus	40-47
32682918-8	2020	RESULTS: GA treatment to cirrhotic mice significantly increased the expression of small intestinal PXR and Regenerating family member 3 alpha (Reg3A), which were otherwise reduced in CCl4 cirrhotic mice.	ginkgolide A	9-11	regenerating islet-derived 3 alpha	Mus musculus	143-148
32682918-12	2020	CONCLUSION: The study showed for the first time that, GA treatment to cirrhotic rodents attenuates BT, by improving PXR and Reg3A expression.	ginkgolide A	54-56	regenerating islet-derived 3 alpha	Mus musculus	124-129
32042047-7	2020	Herein, we showed that melatonin significantly increases goblet cells, Reg3beta, and the ratio of Firmicutes to Bacteriodetes by suppressing Gram-negative bacteria through TLR4 signalling.	Melatonin	23-32	regenerating islet-derived 3 alpha	Mus musculus	71-79
31098404-6	2019	Human REG3A transgenic mice show an increased proportion of L-Ornithine producing lactobacilli in the gut contents, suggesting that gut epithelial REG3A favors the expansion of L-Ornithine producing lactobacilli.	Ornithine	60-71	regenerating islet-derived 3 alpha	Mus musculus	147-152
31182284-4	2019	OBJECTIVE: Our aim was to investigate whether ginsenoside CK could affect the homeostasis of keratinocytes and their expression of psoriasis-associated antimicrobial protein regenerating islet-derived protein 3-alpha (REG3A) and its murine ortholog RegIIIgamma.	Ginsenosides	46-57	regenerating islet-derived 3 alpha	Mus musculus	218-223
31182284-4	2019	OBJECTIVE: Our aim was to investigate whether ginsenoside CK could affect the homeostasis of keratinocytes and their expression of psoriasis-associated antimicrobial protein regenerating islet-derived protein 3-alpha (REG3A) and its murine ortholog RegIIIgamma.	ginsenoside M1	58-60	regenerating islet-derived 3 alpha	Mus musculus	218-223
31098404-6	2019	Human REG3A transgenic mice show an increased proportion of L-Ornithine producing lactobacilli in the gut contents, suggesting that gut epithelial REG3A favors the expansion of L-Ornithine producing lactobacilli.	Ornithine	177-188	regenerating islet-derived 3 alpha	Mus musculus	147-152
25938566-9	2015	Reg3alpha bound the resulting transient fibrin network, accumulated in the inflammatory extracellular matrix (ECM), greatly reduced extracellular ROS levels, and improved cell viability.	Reactive Oxygen Species	146-149	regenerating islet-derived 3 alpha	Mus musculus	0-9
25826674-5	2015	Mice receiving islets with elevated Reg3alpha production exhibited significantly lower blood glucose levels (9.057 +- 0.59 mmol/L versus 13.48 +- 0.35 mmol/L, P < 0.05) and improved glucose-stimulated insulin secretion (1.80 +- 0.17 ng/mL versus 1.16 +- 0.16 ng/mL, P < 0.05) compared with the control group.	Glucose	93-100	regenerating islet-derived 3 alpha	Mus musculus	36-45
25826674-5	2015	Mice receiving islets with elevated Reg3alpha production exhibited significantly lower blood glucose levels (9.057 +- 0.59 mmol/L versus 13.48 +- 0.35 mmol/L, P < 0.05) and improved glucose-stimulated insulin secretion (1.80 +- 0.17 ng/mL versus 1.16 +- 0.16 ng/mL, P < 0.05) compared with the control group.	Glucose	185-192	regenerating islet-derived 3 alpha	Mus musculus	36-45
25826674-7	2015	Further experiments showed that Reg3alpha production dramatically protected cultured islets and pancreatic beta cells from cytokine-induced apoptosis and the impairment of glucose-stimulated insulin secretion.	Glucose	172-179	regenerating islet-derived 3 alpha	Mus musculus	32-41
19509017-7	2009	Administration of Ex-4 or liraglutide for 1 week increased pancreas weight and induced expression of mRNA transcripts encoding the anti-inflammatory proteins pancreatitis-associated protein (PAP) (RegIIIbeta) and RegIIIalpha.	Exenatide	18-22	regenerating islet-derived 3 alpha	Mus musculus	158-224
19343564-5	2009	In MTT cell proliferation assay, Reg3alpha-overexpressing cells exhibited a 2-fold increase in the rate of cell growth.	monooxyethylene trimethylolpropane tristearate	3-6	regenerating islet-derived 3 alpha	Mus musculus	33-42
34099862-7	2021	Our data indicates that REG3A/REG3B promotes persistent ADM through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway.	Doxorubicin	56-59	regenerating islet-derived 3 alpha	Mus musculus	24-29
29133078-13	2018	A similar shift in the composition of the fecal microbiota occurred after a few months in TG mice heterozygous for REG3A that harbored a wild-type maternal microbiota at birth; these mice developed less-severe forms of colitis following DSS administration.	dss	237-240	regenerating islet-derived 3 alpha	Mus musculus	115-120
29133078-14	2018	Cohoused and germ-free mice fed feces from REG3A-TG mice and given DSS developed less-severe forms of colitis and had reduced lipopolysaccharide activation of the toll-like receptor 4 and increased survival times compared with mice not fed feces from REG3A-TG mice.	dss	67-70	regenerating islet-derived 3 alpha	Mus musculus	251-256
29133078-15	2018	REG3A TG mice developed only mild colonic inflammation after exposure to 2,4,6-trinitrobenzene sulfonic acid, compared with control mice.	Trinitrobenzenesulfonic Acid	73-108	regenerating islet-derived 3 alpha	Mus musculus	0-5
29133078-17	2018	Fecal samples from REG3A-TG mice had lower levels of ROS than feces from control mice during DSS administration.	Reactive Oxygen Species	53-56	regenerating islet-derived 3 alpha	Mus musculus	19-24
29133078-17	2018	Fecal samples from REG3A-TG mice had lower levels of ROS than feces from control mice during DSS administration.	dss	93-96	regenerating islet-derived 3 alpha	Mus musculus	19-24
25938566-13	2015	Preventing fibrin network formation with heparin suppressed the prosurvival effect of Reg3alpha.	Heparin	41-48	regenerating islet-derived 3 alpha	Mus musculus	86-95
25938566-14	2015	CONCLUSIONS: Reg3alpha is an ECM-targeted ROS scavenger that binds the fibrin scaffold resulting from hepatocyte death during ALF.	Reactive Oxygen Species	42-45	regenerating islet-derived 3 alpha	Mus musculus	13-22