PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33742315-10	2021	By RT-PCR and Western blot analysis, LY294002 blocked the PI3K/AKT-induced loss of E-cadherin expression and de novo increase of the expression of alpha-SMA in a time- and dose-dependent manner.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	37-45	cadherin 1	Mus musculus	83-93
32070194-9	2021	Moreover, the efflux of FAs and their reuptake or subsequent extracellular trafficking to adjacent cells may play an important role in cell-to-cell lipid exchange and signaling.Abbreviations: ACTB: beta actin; ADRA1A: adrenergic receptor alpha, 1a; ALB: albumin; ATG5: autophagy related 5; ATG7: autophagy related 7; BafA1: bafilomycin A1; BECN1: beclin 1; BHBA: beta-hydroxybutyrate; BSA: bovine serum albumin; CDH1: e-cadherin; CQ: chloroquine; CTSB: cathepsin B; DGAT: diacylglycerol O-acyltransferase; FA: fatty acid; HFD: high-fat diet; LAMP1: lysosomal-associated membrane protein 1; LD: lipid droplet; LIPA/LAL: lysosomal acid lipase A; LLME: Leu-Leu methyl ester hydrobromide; MAP1LC3B/LC3: microtubule associated protein 1 light chain 3 beta; MCOLN1/TRPML1: mucolipin 1; MEF: mouse embryo fibroblast; PBS: phosphate-buffered saline; PIK3C3/VPS34: phosphatidylinositol 3-kinase catalytic subunit type 3; PLIN: perilipin; PNPLA2/ATGL patatin-like phospholipase domain containing 2; RUBCN (rubicon autophagy regulator); SM: sphingomyelin; TAG: triacylglycerol; TMEM192: transmembrane protein 192; VLDL: very low density lipoprotein.	Fatty Acids	24-27	cadherin 1	Mus musculus	412-416
32070194-9	2021	Moreover, the efflux of FAs and their reuptake or subsequent extracellular trafficking to adjacent cells may play an important role in cell-to-cell lipid exchange and signaling.Abbreviations: ACTB: beta actin; ADRA1A: adrenergic receptor alpha, 1a; ALB: albumin; ATG5: autophagy related 5; ATG7: autophagy related 7; BafA1: bafilomycin A1; BECN1: beclin 1; BHBA: beta-hydroxybutyrate; BSA: bovine serum albumin; CDH1: e-cadherin; CQ: chloroquine; CTSB: cathepsin B; DGAT: diacylglycerol O-acyltransferase; FA: fatty acid; HFD: high-fat diet; LAMP1: lysosomal-associated membrane protein 1; LD: lipid droplet; LIPA/LAL: lysosomal acid lipase A; LLME: Leu-Leu methyl ester hydrobromide; MAP1LC3B/LC3: microtubule associated protein 1 light chain 3 beta; MCOLN1/TRPML1: mucolipin 1; MEF: mouse embryo fibroblast; PBS: phosphate-buffered saline; PIK3C3/VPS34: phosphatidylinositol 3-kinase catalytic subunit type 3; PLIN: perilipin; PNPLA2/ATGL patatin-like phospholipase domain containing 2; RUBCN (rubicon autophagy regulator); SM: sphingomyelin; TAG: triacylglycerol; TMEM192: transmembrane protein 192; VLDL: very low density lipoprotein.	Fatty Acids	24-27	cadherin 1	Mus musculus	418-428
33569850-5	2021	We showed for the first time that miR-21a-5p expression is increased in the peritoneal exosomes of mice with dextran sulphate sodium induced enteritis and that miR-21a-5p expression correlates negatively with E-cadherin expression in enterocytes.	dextran sulphate sodium	109-132	cadherin 1	Mus musculus	209-219
33614637-7	2021	Moreover, it was found that the growth inhibition of 4T-1 cells by doxorubicin was positively correlated with the expression of E-cadherin.	Doxorubicin	67-78	cadherin 1	Mus musculus	128-138
33547048-1	2021	E-cadherin is a calcium-dependent cell-cell adhesion molecule extensively studied for its involvement in tissue formation, epithelial cell behavior, and suppression of cancer.	Calcium	16-23	cadherin 1	Mus musculus	0-10
33507617-10	2021	Moreover, BPP treatment decreased the expression levels of several transcriptional factors involved in regulating E-cadherin expression, including snail, twist and ZEB1.	bpp	10-13	cadherin 1	Mus musculus	114-124
33614637-8	2021	In a mouse breast cancer xenograft model, E-cadherin was overexpressed in the primary tumor tissues of the doxorubicin-treated mice.	Doxorubicin	107-118	cadherin 1	Mus musculus	42-52
33383483-16	2021	In high glucose induced HK-2 cells, expression levels of miR-30b-5p and E-cadherin were decreased, while SNAI1, a-SMA and Vimentin were increased.	Glucose	8-15	cadherin 1	Mus musculus	72-82
32617970-4	2021	In mice, we found that 3 days of dextran sulfate sodium-induced colitis increased Dab2/E-cadherin colocalization, which was decreased as colitis progressed to 6 and 9 days.	Dextran Sulfate	33-55	cadherin 1	Mus musculus	87-97
33430854-15	2021	These indicators (Ki67, VEGF-A,N-cadherin) were decreased and E-cadherin expression was up-regulated in A549 mice that treated with fucoidan.	fucoidan	132-140	cadherin 1	Mus musculus	62-72
33211830-5	2021	The PSA-CreER T2 transgenic mouse strain expressing tamoxifen-inducible CreER T2 recombinase driven by a 6-kb human PSA promoter/enhancer was crossed with the B6.129-Cdh1  tm2Kem/J mouse to generate bigenic PSA-CreER T2/Cdh1  -/- mice.	Tamoxifen	52-61	cadherin 1	Mus musculus	220-224
32504614-0	2021	GRANZYME B CONTRIBUTES TO BARRIER DYSFUNCTION IN OXAZOLONE-INDUCED SKIN INFLAMMATION THROUGH E-CADHERIN AND FILAGGRIN CLEAVAGE.	Oxazolone	49-58	cadherin 1	Mus musculus	93-103
33414476-4	2021	Knockdown of HDAC5 ameliorated high glucose-induced epithelial-mesenchymal transition (EMT) of HK2 cells, indicated in the increased E-cadherin and decreased alpha-SMA, via the downregulation of TGF-beta1.	Glucose	36-43	cadherin 1	Mus musculus	133-143
33211830-6	2021	Deletion of E-cadherin was induced by transient administration of tamoxifen when mice reached sexual maturity (7 weeks of age).	Tamoxifen	66-75	cadherin 1	Mus musculus	12-22
33240413-7	2021	In the parts of colon tumors from AOM/DSS mice, particularly in mice at 30 weeks, the positive signal of E-cadherin was clearly reduced in the cell membranes.	dss	38-41	cadherin 1	Mus musculus	105-115
33344246-3	2020	Magnolol showed significant anti-growth effect in an orthotopic xenograft nude mouse model, and immunohistochemical staining of the xenografts revealed that Magnolol suppressed vimentin expression and facilitated E-cadherin expression.	magnolol	157-165	cadherin 1	Mus musculus	213-223
33327637-8	2020	The inhibitory effect of SM on EMT revealed in vitro was further confirmed in a metastatic model of murine B16 melanoma: SM was found to effectively block metastatic dissemination of melanoma B16 cells in vivo, increase expression of E-cadherin and suppress expression of MMP-9 in lung metastatic foci.	Samarium	25-27	cadherin 1	Mus musculus	234-244
33327637-8	2020	The inhibitory effect of SM on EMT revealed in vitro was further confirmed in a metastatic model of murine B16 melanoma: SM was found to effectively block metastatic dissemination of melanoma B16 cells in vivo, increase expression of E-cadherin and suppress expression of MMP-9 in lung metastatic foci.	Samarium	121-123	cadherin 1	Mus musculus	234-244
33344246-6	2020	Western blot and rt-PCR showed that Magnolol suppressed epithelial-mesenchymal-transition by increasing the expression level of E-cadherin and decreasing those of N-cadherin and vimentin.	magnolol	36-44	cadherin 1	Mus musculus	128-138
32770866-0	2020	Expression of discoidin domain receptor 1 and E-cadherin in epidermis affects melanocyte behavior in rhododendrol-induced leukoderma mouse model.	rhododendrol	101-113	cadherin 1	Mus musculus	46-56
33496144-13	2020	In addition, immunohistochemical experiments confirmed that lupeol could up-regulate the expression of E-cadherin in tumor tissues of nude mice, reduce the expression of N-cadherin, and inhibit the metastasis of liver cancer H22 cells in the lungs of mice.	lupeol	60-66	cadherin 1	Mus musculus	103-113
33202982-8	2020	However, the reduced induction of the epithelial markers of E-cadherin and P-cadherin was restored by tangeretin in diabetic podocytes.	tangeretin	102-112	cadherin 1	Mus musculus	60-70
32770866-3	2020	In this report, we showed that the expression of discoidin domain receptor 1 and E-cadherin, known adhesion molecules, was variable or absent in the epidermis of rhododendrol-induced leukoderma (RDIL) mice during the depigmentation process.	rhododendrol	162-174	cadherin 1	Mus musculus	81-91
32912432-4	2020	Compared with the vehicle treatment, GA treatment inhibited the expression of vimentin and increased the expression of E-cadherin.	galangin	37-39	cadherin 1	Mus musculus	119-129
33023995-8	2020	Inhibition of Wnt signaling via ICG-001 resulted in significantly decreased nasal polypoid lesions (p<0.001), EMT-related markers (p=0.019 for E-cadherin and p=0.002 for vimentin) and the mRNA levels of IL-4 (p<0.001) and IL-17A (p=0.004) compared with the positive control group.	Indocyanine Green	32-35	cadherin 1	Mus musculus	143-153
33210594-6	2020	In addition, the protein expression levels of ZO-1, occludin, N-cadherin, E-cadherin and beta-catenin were significantly down-regulated in D-gal-treated group, while the protein expression levels of p-p38MAPK were significantly up-regulated.	Galactose	139-144	cadherin 1	Mus musculus	74-84
32840012-0	2020	Effect of epigallocatechin-3-gallate on the status of DNA methylation of E-cadherin promoter region on endometriosis mouse.	epigallocatechin gallate	10-36	cadherin 1	Mus musculus	73-83
32840012-1	2020	AIM: To evaluate whether epigallocatechin-3-gallate acts on endometriosis mouse, and changes the status of DNA methylation of E-cadherin promoter region.	epigallocatechin gallate	25-51	cadherin 1	Mus musculus	126-136
32840012-9	2020	CONCLUSION: Epigallocatechin-3-gallate may inhibit the growth of endometrial lesion, affect the expression of E-cadherin on the cell membrane and reduce the status of DNA methylation of E-cadherin promoter region.	epigallocatechin gallate	12-38	cadherin 1	Mus musculus	110-120
32840012-9	2020	CONCLUSION: Epigallocatechin-3-gallate may inhibit the growth of endometrial lesion, affect the expression of E-cadherin on the cell membrane and reduce the status of DNA methylation of E-cadherin promoter region.	epigallocatechin gallate	12-38	cadherin 1	Mus musculus	186-196
32896720-11	2020	In HNC cells with low expression of E-cadherin, the treatment of 5-azacitidine diminished the hypermethylation of CDH1, resulting in increased E-cadherin expression and decreased ferroptosis susceptibility.	Azacitidine	65-78	cadherin 1	Mus musculus	36-46
32896720-11	2020	In HNC cells with low expression of E-cadherin, the treatment of 5-azacitidine diminished the hypermethylation of CDH1, resulting in increased E-cadherin expression and decreased ferroptosis susceptibility.	Azacitidine	65-78	cadherin 1	Mus musculus	114-118
32896720-11	2020	In HNC cells with low expression of E-cadherin, the treatment of 5-azacitidine diminished the hypermethylation of CDH1, resulting in increased E-cadherin expression and decreased ferroptosis susceptibility.	Azacitidine	65-78	cadherin 1	Mus musculus	143-153
33061421-11	2020	LINC01116 knockdown resulted in a 2.1-fold increase in E-cadherin expression and a 56% reduction in Vimentin expression in A549/DDP cells, and LINC01116 overexpression resulted in a 45% reduction in E-cadherin expression and a 1.82-fold increase in Vimentin expression in A549 cells.	linc01116	0-9	cadherin 1	Mus musculus	55-65
33061421-11	2020	LINC01116 knockdown resulted in a 2.1-fold increase in E-cadherin expression and a 56% reduction in Vimentin expression in A549/DDP cells, and LINC01116 overexpression resulted in a 45% reduction in E-cadherin expression and a 1.82-fold increase in Vimentin expression in A549 cells.	linc01116	0-9	cadherin 1	Mus musculus	199-209
32522570-8	2020	KEY FINDINGS: M2-like TAMs were enriched in TC tissues, and they promoted the colony/sphere formation, accompanied with a down-regulated expression in E-cadherin and an up-regulated expression in N-cadherin, Vimentin and other stemness-associated markers (CD133, Oct4, c-Myc) in TC cells.	tams	22-26	cadherin 1	Mus musculus	151-161
32833955-9	2020	RESULTS We found that QXT treatment increased E-cadherin expression and decreased extracellular-signal-regulated kinase (ERK) phosphorylation levels in the lung tissues of OVA-challenged mice.	1-[3-(7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinolin-6-ylmethyl)phenyl]-3,3-diethyl-azetidine-2,4-dione	22-25	cadherin 1	Mus musculus	46-56
32619930-0	2020	Inhibition of PIM1 kinase attenuates bleomycin-induced pulmonary fibrosis in mice by modulating the ZEB1/E-cadherin pathway in alveolar epithelial cells.	Bleomycin	37-46	cadherin 1	Mus musculus	105-115
32799885-8	2020	In addition, O-PMs affected the expression of fibronectin, E-cadherin, and vimentin through modulating ETS-1 expression.	o-pms	13-18	cadherin 1	Mus musculus	59-69
32825724-11	2020	In a mouse model, tepotinib exhibited good antitumor growth activity along with increased E-cadherin and decreased phosphorylated c-MET (phospho-c-MET) protein levels.	EMD1214063	18-27	cadherin 1	Mus musculus	90-100
33210606-8	2020	MgD (with Ca:Mg ratios >1) elevated intracellular Ca levels, calpain activity and TRPM7 expression, as well as oxidative stress and cell migration, consistent with observed degradation of full-length E-cadherin, beta-catenin, and N-terminal FAK.	Magnesium	0-2	cadherin 1	Mus musculus	200-210
32597022-11	2020	Moreover, circ-AKT3/miR-296-3p/E-cadherin modulated the extracellular matrix of mouse mesangial cells in high-concentration (25 mmol/L) glucose, inhibiting the synthesis of related extracellular matrix protein.	Glucose	136-143	cadherin 1	Mus musculus	31-41
32774701-7	2020	Folic acid-induced injury of mesangial cells showed inhibited cell proliferation, promoted apoptosis, increased LC3II expression, decreased p62 expression, increased autophagic vacuoles and expression of STAT3 and p-mTOR as well as decreased E-cadherin expression and increased Vimentin expression.	Folic Acid	0-10	cadherin 1	Mus musculus	242-252
32626974-6	2020	In vitro, Sal B downregulated the expression levels of HPSE/FGF-2/TGF-beta1/alpha-smooth muscle actin and upregulated the expression levels of SDC1/E-cadherin in angiotensin II-stimulated HK-2 cells in a dose-dependent manner.	salvianolic acid B	10-15	cadherin 1	Mus musculus	148-158
32319542-8	2020	Furthermore, APS significantly inhibited the epithelial-mesenchymal transition (EMT), as evidenced by an increased level of E-cadherin and a decreased expression of vimentin and alpha smooth muscle actin.	aps	13-16	cadherin 1	Mus musculus	124-134
33336024-11	2020	ED-71 markedly inhibited the expression of Akt and E-cadherin, either detected by immunohistochemistry or RT-PCR.	eldecalcitol	0-5	cadherin 1	Mus musculus	51-61
33336024-12	2020	ED-71 treatment can inhibit the hepatoma agent proliferation by increasing the E-cadherin expression and decreasing Akt expression.	eldecalcitol	0-5	cadherin 1	Mus musculus	79-89
33133685-4	2020	Results: We found that BT treatment restored the expression of Occludin, E-cadherin (epithelial markers) while suppressing the levels of different mesenchymal markers in HCC cells and tumor tissues.	brusatol	23-25	cadherin 1	Mus musculus	73-83
32669976-8	2020	Nicotine treatment also increased E-cadherin and ZO-1 and decreased fibronectin and vimentin expression.	Nicotine	0-8	cadherin 1	Mus musculus	34-44
32499696-5	2020	NR_136400 downregulation facilitated EMT by inhibiting the expression of E-cadherin and elevating the expression of ZEB1, Snail, and fibronectin.	nr_136400	0-9	cadherin 1	Mus musculus	73-83
32303124-9	2020	These flavonoids significantly inhibited thymic stromal lymphopoietin (TSLP), increased occludin and restored E-cadherin in vivo and in vitro.	Flavonoids	6-16	cadherin 1	Mus musculus	110-120
32617074-7	2020	Transduction of lentivirus expressing miR-135a reduced the level of inflammatory mediators in lung tissues from silica-treated mice and improved pulmonary fibrosis which was consistent with the downregulated alpha-SMA but enhanced E-cadherin.	Silicon Dioxide	112-118	cadherin 1	Mus musculus	231-241
31986917-5	2020	This FP agonist also decreased E-cadherin expression levels in the cell-cell contact zone, and this was canceled by the addition of PD168393.	PD168393	132-140	cadherin 1	Mus musculus	31-41
32456234-4	2020	Given this background, a virtual screening was performed to identify novel specific inhibitors of Hakai, targeted against its phosphotyrosine-binding pocket, where phosphorylated-E-cadherin specifically binds.	Phosphotyrosine	126-141	cadherin 1	Mus musculus	179-189
32326790-4	2021	After inhibiting Fascin-1, the expression of STAT3 decreased, the expression of N-cadherin decreased, and the expression of E-cadherin increased.Conclusion BP-1-102 is a novel drug with a great potential in pituitary tumors.	BP-1-102	156-164	cadherin 1	Mus musculus	124-134
31804606-8	2020	On the other hand, GA treatment significantly decreased the expression of mesenchymal cell markers alpha-smooth muscle actin (alpha-SMA) and vimentin, and upregulated E-cadherin expression in the kidney, suggesting the suppression of tubular epithelial-mesenchymal transition (EMT) partially via inhibiting both TGF-beta/Smad and MAPK (ERK, JNK, p38) signaling pathways.	ganoderic acid	19-21	cadherin 1	Mus musculus	167-177
32146192-7	2020	During incubation with SE-PA epithelial cells underwent conversion and assumed fibroblast phenotype characterized by a decrease in epithelial cells markers (CDH1, CLDN1, JUP) and increase in mesenchymal cells markers (FN1, VIM, CDH2).	se-pa	23-28	cadherin 1	Mus musculus	157-161
32566617-8	2020	Furthermore, taxifolin decreased invasive cells, reduced N-cadherin and vimentin while increased E-cadherin expression, indicating that epithelial-mesenchymal transition (EMT) was inhibited.	taxifolin	13-22	cadherin 1	Mus musculus	97-107
32266025-9	2020	Following celecoxib treatment, the expression of E-cadherin was significantly increased whereas the expression of N-cadherin was significantly decreased.	Celecoxib	10-19	cadherin 1	Mus musculus	49-59
32054021-6	2020	We next found that the PTPN2, Factor B, and VRK1 concentrations in silicotic rats silicosis and SiO2-stimulated MLE-12 cells were significantly higher than control groups.More importantly, we found that overexpression of PTPN2 simultaneously decreased the expression of phospho-signal transducer and activator of transcription 3 (p-STAT3) and Vimentin, while increasing E-cadherin expression.	Silicon Dioxide	96-100	cadherin 1	Mus musculus	370-380
32048404-6	2020	Moreover, the expression of uterine receptivity-related factors-LIF, E-cadherin, and HOXA10-were all downregulated, while the number of uterine glands was reduced in the high GABA dose group.	gamma-glutamyl-alpha-aminobutyrate	175-179	cadherin 1	Mus musculus	69-79
32355512-4	2020	Overexpression of miR-19 could decrease the expression of E-cadherin and increase the expression of alpha-SMA and fibronectin, while inhibition of miR-19 reverses TGF-beta1-induced EMT.	mir-19	18-24	cadherin 1	Mus musculus	58-68
32395292-12	2020	A549 cell invasion and the number of microtubule nodules were significantly lower in the wogonoside 20 microM and the wogonoside 50 microM groups (P<0.05) compared with the wogonoside 0 microM group, while the rate of scratch closure and the protein levels of VEGF, N-cadherin, and Vimentin were all significantly reduced (P<0.05), and the expression level of E-cadherin was significantly increased (P<0.05).	wogonoside	89-99	cadherin 1	Mus musculus	360-370
32395292-12	2020	A549 cell invasion and the number of microtubule nodules were significantly lower in the wogonoside 20 microM and the wogonoside 50 microM groups (P<0.05) compared with the wogonoside 0 microM group, while the rate of scratch closure and the protein levels of VEGF, N-cadherin, and Vimentin were all significantly reduced (P<0.05), and the expression level of E-cadherin was significantly increased (P<0.05).	wogonoside	118-128	cadherin 1	Mus musculus	360-370
32176678-8	2020	In vivo, we found that DHA can reduce lung metastasis formation caused by CSCs and prolong survival in mice, and can inhibit STAT3 activation, downregulate MMP-9, and upregulate E-cadherin in lung metastatic tumors.	artenimol	23-26	cadherin 1	Mus musculus	178-188
31887935-11	2020	The results also showed that CSO/Dex/LNPs had better anti-inflammatory effects than free Dex, which could reduce colonic atrophy, reduce histomorphological changes and increase the expression of E-cadherin in the colon.	Dexamethasone	33-36	cadherin 1	Mus musculus	195-205
32395292-12	2020	A549 cell invasion and the number of microtubule nodules were significantly lower in the wogonoside 20 microM and the wogonoside 50 microM groups (P<0.05) compared with the wogonoside 0 microM group, while the rate of scratch closure and the protein levels of VEGF, N-cadherin, and Vimentin were all significantly reduced (P<0.05), and the expression level of E-cadherin was significantly increased (P<0.05).	wogonoside	118-128	cadherin 1	Mus musculus	360-370
32194780-6	2020	Curcumol upregulated the expression of E-cadherin and downregulated the expression of N-cadherin, MMP2 and MMP9 in mouse melanoma B16 cell.	curcumol	0-8	cadherin 1	Mus musculus	39-49
32095719-8	2020	In addition, Abx pretreatment regulated macrophage cell polarization in the ileum, downregulated TGF-beta1, phosphorylated Smad-3 and alpha-SMA protein levels, and upregulated E-cadherin protein expression.	CHEMBL369125	13-16	cadherin 1	Mus musculus	176-186
32194804-12	2020	Oral administration of AE for 4 weeks caused a significant regression of mouse xenograft tumor (>60%) that derived from OV4855 cells and decreased the expression of endothelial cell antigen-CD31, HIF-1alpha, IGF1R and SNAIL1 and increased the expression of E-cadherin in tumor tissues.	alanylglutamic acid	23-25	cadherin 1	Mus musculus	257-267
31526907-1	2020	BACKGROUND &amp; AIMS: E-cadherin (Cdh1) is a key molecule for adherence required for maintenance of structural homeostasis.	Adenosine Monophosphate	12-15	cadherin 1	Mus musculus	23-33
31526907-1	2020	BACKGROUND &amp; AIMS: E-cadherin (Cdh1) is a key molecule for adherence required for maintenance of structural homeostasis.	Adenosine Monophosphate	12-15	cadherin 1	Mus musculus	35-39
31642174-5	2020	Moreover, GI254023X, a potent ADAM-10 (a disintegrin and metalloprotease) inhibitor, was capable of rescuing partially the expression of E-cadherin in the TIMP-3-null hepatocytes.	3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide	10-19	cadherin 1	Mus musculus	137-147
31708110-5	2020	The mice treated with the ISO-1 ameliorated airway hyper-reactivity, airway inflammation, increased serum IgE levels, the aberrant arrangement of E-cadherin as well as the release of Th2 cytokines induced by HDM.	iso-	26-30	cadherin 1	Mus musculus	146-156
31579944-11	2020	In HPMCs, treatment with EZH2 siRNA or 3-DZNeP suppressed TGF-beta1-induced upregulation of alpha-SMA and Collagen I and preserved E-cadherin.	3-deazaneplanocin	39-46	cadherin 1	Mus musculus	131-141
31642174-7	2020	In a similar fashion, depression of the E-cadherin/beta-catenin complex mediated by TIMP-3 deletion and knockdown of beta-catenin by small interfering RNA (siRNA) were both capable of inducing caspase activation in isolated hepatocytes subjected to H2 O2 oxidative stress.	Water	249-254	cadherin 1	Mus musculus	40-50
31465880-6	2020	After dexamethasone treatment, the airway inflammation was relieved and the expression of E-cadherin was reduced.	Dexamethasone	6-19	cadherin 1	Mus musculus	90-100
31847310-8	2019	Both cadmium and lead significantly decreased the number of Renca cell aggregates, consistent with the disruption of the cadherin/catenin complex.	Cadmium	5-12	cadherin 1	Mus musculus	121-129
31576468-10	2020	RESULTS: E-Cadherin was significantly higher in the DPP4I group than in the control group.	dpp4i	52-57	cadherin 1	Mus musculus	9-19
31576468-12	2020	Positive staining for E-cadherin and occludin varied widely between the control and DPP4I groups.	dpp4i	84-89	cadherin 1	Mus musculus	22-32
31576468-13	2020	CONCLUSION: Up-regulation of E-cadherin and occludin by DPP4I may be correlated with the anti-inflammatory action of DPP4I.	dpp4i	56-61	cadherin 1	Mus musculus	29-39
31576468-13	2020	CONCLUSION: Up-regulation of E-cadherin and occludin by DPP4I may be correlated with the anti-inflammatory action of DPP4I.	dpp4i	117-122	cadherin 1	Mus musculus	29-39
31879741-9	2019	After Cy-3-glu treatment, the expression levels of p-AKT (P < 0.05), N-cadherin and vimentin (P < 0.001) were decreased significantly, and the expression level of E-cadherin was dramatically increased (P < 0.05).	cyanidin-3-o-glucoside	6-14	cadherin 1	Mus musculus	163-173
31323300-11	2019	The expression of indicators of EMT including alpha-SMA, vimentin and E-cadherin was significantly improved after given different beta-carboline alkaloids.	beta-carboline alkaloids	130-154	cadherin 1	Mus musculus	70-80
30905239-10	2019	UA treatment also decreased alpha-SMA and preserved E-cadherin in vivo.	ursolic acid	0-2	cadherin 1	Mus musculus	52-62
30905239-12	2019	UA pretreatment prevented E-cadherin loss and diminished alpha-SMA expression in HK-2 cells.	ursolic acid	0-2	cadherin 1	Mus musculus	26-36
31825014-6	2019	Inhalation of e-cig aerosol containing PG alone significantly augmented the lung levels of various homeostasis/repair mediators (PPARgamma, ADRP, ACTA2, CTNNB1, LEF1, beta-catenin, E-cadherin, and MMP2) in a sex-dependent manner when compared to air controls.	Propylene Glycol	39-41	cadherin 1	Mus musculus	181-191
31588120-7	2019	However, transfection of a miR-339-5p inhibitor led to a significant increase in the invasion cell number and wound healing rate (P<0.001), with significantly suppressed E-cadherin expression and increased vimentin expression (P<0.001).	mir-339-5p	27-37	cadherin 1	Mus musculus	170-180
31588120-9	2019	With miR-339-5p and ZNF689 transfection, the invasion cell number and wound healing rate were significantly increased compared with those in the miR-339-5p group (P<0.001), with significantly increased expression of ZNF689 and vimentin and suppressed E-cadherin expression (P<0.001).	mir-339-5p	5-15	cadherin 1	Mus musculus	251-261
31540244-4	2019	In addition, two of these inhibitors, ARQ-092 and MK2206, preferentially targeted mouse-derived gastric Cdh1-/- organoids for growth arrest.	Miransertib	38-45	cadherin 1	Mus musculus	104-108
31540244-4	2019	In addition, two of these inhibitors, ARQ-092 and MK2206, preferentially targeted mouse-derived gastric Cdh1-/- organoids for growth arrest.	MK 2206	50-56	cadherin 1	Mus musculus	104-108
31317666-9	2019	A549 cells with silencing of lncRNA H19, overexpression of CDH1 or reduced CDH1 methylation by demethylating agent 5-Az had suppressed cell proliferation, sphere-forming ability, apoptosis, migration and invasion, in addition to inhibited EMT process.	5-az	115-119	cadherin 1	Mus musculus	75-79
31695406-8	2019	Mechanistically, treatment with chelidonine increased the expression of epithelial indicator E-cadherin, whereas it decreased the expression of mesenchymal indicators N-cadherin and Vimentin.	chelidonine	32-43	cadherin 1	Mus musculus	93-103
31444332-3	2019	Here we show that E-cadherin loss induces extrusion of luminal MMECs to the basal lamina.	Phenobarbital	55-62	cadherin 1	Mus musculus	18-28
31496729-10	2019	Oxymatrine significantly inhibited cell migration and invasion, downregulated the expression of N-cadherin, vimentin, and Snail in MDA-MB-231 and 4T1 cells, but upregulated the expression of E-cadherin in 4T1 cells.	oxymatrine	0-10	cadherin 1	Mus musculus	191-201
31173170-7	2019	In mice with OVA-RSV induced chronic asthma, ORMDL3 and sphingosine kinase 1 (SPHK1) were upregulated whereas the junction related proteins Claudin-18 and E-cadherin were downregulated.	ova-rsv	13-20	cadherin 1	Mus musculus	155-165
31128153-6	2019	In addition, CS exposure led to decreased levels of E-cadherin and to increased N-cadherin, vimentin, and alpha-SMA, indicating that the EMT was induced in mouse lung tissues.	Cesium	13-15	cadherin 1	Mus musculus	52-62
31085231-3	2019	We found that bleomycin-induced lung fibrosis was associated with increased transforming growth factor (TGF)-beta1, alpha-smooth muscle actin (alpha-SMA) and decreased E-cadherin expression in lung tissues, indicating EMT formation.	Bleomycin	14-23	cadherin 1	Mus musculus	168-178
31029000-5	2019	It was also showed that roscovitine coordinately inhibited the expression of collagen, alpha-SMA, TGF-beta1, and retaining E-cadherin expression.	Roscovitine	24-35	cadherin 1	Mus musculus	123-133
31029000-7	2019	It was revealed that roscovitine successfully reduced alpha-SMA expression and ameliorated the decrease expression of E-cadherin, the two markers of tubular cell EMT.	Roscovitine	21-32	cadherin 1	Mus musculus	118-128
30976056-3	2019	The expression of fibrotic markers (fibronectin and alpha-SMA) was remarkably reduced, while the expression of the epithelial marker E-cadherin was restored after DMAMCL treatment both in the UUO and IRI mice.	dimethylaminomicheliolide	163-169	cadherin 1	Mus musculus	133-143
31273057-13	2019	Moreover, E-cadherin expression was increased while vimentin and Cytochrome C expressions were decreased by NAC.	Acetylcysteine	108-111	cadherin 1	Mus musculus	10-20
31199830-0	2019	Kaiso-induced intestinal inflammation is preceded by diminished E-cadherin expression and intestinal integrity.	kaiso	0-5	cadherin 1	Mus musculus	64-74
30741526-0	2019	Cdh1-Mediated Metabolic Switch from Pentose Phosphate Pathway to Glycolysis Contributes to Sevoflurane-Induced Neuronal Apoptosis in Developing Brain.	Pentosephosphates	36-53	cadherin 1	Mus musculus	0-4
30978648-9	2019	Icariin treatment also significantly inhibited the increased Smad2/3 and decreased E-cadherin protein expressions in the kidneys of UUO mice.	icariin	0-7	cadherin 1	Mus musculus	83-93
30741526-0	2019	Cdh1-Mediated Metabolic Switch from Pentose Phosphate Pathway to Glycolysis Contributes to Sevoflurane-Induced Neuronal Apoptosis in Developing Brain.	Sevoflurane	91-102	cadherin 1	Mus musculus	0-4
30741526-6	2019	We found that prolonged sevoflurane anesthesia significantly reduces the Cdh1 level in P7 mice compared to in the P21 ones; moreover, the decrease in Cdh1 level results in a switch in glucose metabolism from the PPP to neuronal glycolysis.	Sevoflurane	24-35	cadherin 1	Mus musculus	73-77
30741526-6	2019	We found that prolonged sevoflurane anesthesia significantly reduces the Cdh1 level in P7 mice compared to in the P21 ones; moreover, the decrease in Cdh1 level results in a switch in glucose metabolism from the PPP to neuronal glycolysis.	Sevoflurane	24-35	cadherin 1	Mus musculus	150-154
30741526-6	2019	We found that prolonged sevoflurane anesthesia significantly reduces the Cdh1 level in P7 mice compared to in the P21 ones; moreover, the decrease in Cdh1 level results in a switch in glucose metabolism from the PPP to neuronal glycolysis.	Glucose	184-191	cadherin 1	Mus musculus	150-154
30741526-8	2019	As a result, sevoflurane induces neuroapoptosis through Cdh1-mediated glucose metabolism reprogramming.	Sevoflurane	13-24	cadherin 1	Mus musculus	56-60
30741526-8	2019	As a result, sevoflurane induces neuroapoptosis through Cdh1-mediated glucose metabolism reprogramming.	Glucose	70-77	cadherin 1	Mus musculus	56-60
30741526-9	2019	Our study demonstrates a critical role of Cdh1 in sevoflurane-induced neuroapoptosis by shifting PPP to the glycolytic pathway in the developing brain.	Sevoflurane	50-61	cadherin 1	Mus musculus	42-46
31043583-0	2019	3-deazaneplanocin A protects against cisplatin-induced renal tubular cell apoptosis and acute kidney injury by restoration of E-cadherin expression.	3-deazaneplanocin	0-19	cadherin 1	Mus musculus	126-136
31043583-0	2019	3-deazaneplanocin A protects against cisplatin-induced renal tubular cell apoptosis and acute kidney injury by restoration of E-cadherin expression.	Cisplatin	37-46	cadherin 1	Mus musculus	126-136
31043583-5	2019	3-DZNeP treatment did not affect activation of extracellular signal-regulated kinase (ERK) 1/2, p38 or c-Jun N-terminal kinases (JNK) 1/2, which contribute to renal epithelial cell death, but caused dose-dependent restoration of E-cadherin in mTECs exposed to cisplatin.	3-deazaneplanocin	0-7	cadherin 1	Mus musculus	229-239
31043583-6	2019	Silencing of E-cadherin expression by siRNA abolished the cytoprotective effects of 3-DZNeP.	3-deazaneplanocin	84-91	cadherin 1	Mus musculus	13-23
31043583-8	2019	Finally, administration of 3-DZNeP attenuated renal dysfunction, morphological damage, and renal tubular cell death, which was accompanied by E-cadherin preservation, in a mouse model of cisplatin nephrotoxicity.	3-deazaneplanocin	27-34	cadherin 1	Mus musculus	142-152
31043583-9	2019	Overall, these data indicate that 3-DZNeP suppresses cisplatin-induced tubular epithelial cell apoptosis and acute kidney injury via an E-cadherin-dependent mechanism, and suggest that combined application of 3-DZNeP with cisplatin would be a novel chemotherapeutic strategy that enhances the anti-tumor effect of cisplatin and reduces its nephrotoxicity.	3-deazaneplanocin	34-41	cadherin 1	Mus musculus	136-146
31043583-9	2019	Overall, these data indicate that 3-DZNeP suppresses cisplatin-induced tubular epithelial cell apoptosis and acute kidney injury via an E-cadherin-dependent mechanism, and suggest that combined application of 3-DZNeP with cisplatin would be a novel chemotherapeutic strategy that enhances the anti-tumor effect of cisplatin and reduces its nephrotoxicity.	Cisplatin	53-62	cadherin 1	Mus musculus	136-146
30959577-5	2021	Fructose drinking significantly elevated plasma bacterial endotoxin levels, likely resulting from decreased levels of intestinal tight junction (TJ) proteins (zonula occludens 1, occludin, claudin-1, and claudin-4), adherent junction (AJ) proteins (beta-catenin and E-cadherin), and desmosome plakoglobin, along with alpha-tubulin, in wild-type rodents, but not in fructose-exposed Cyp2e1-null mice.	Fructose	0-8	cadherin 1	Mus musculus	266-276
31013617-8	2019	ADAM10 inhibitor (GI254023X) blocked the toxin-induced fluid accumulation and E-cadherin loss in the mouse ileal loop.	3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide	18-27	cadherin 1	Mus musculus	78-88
30517707-9	2019	At the same time, membrane levels of E-cadherin and beta-catenin were significantly decreased after TDI inhalation, which were inhibited by GSK2193874 or HC030031.	Toluene 2,4-Diisocyanate	100-103	cadherin 1	Mus musculus	37-47
30867745-8	2019	Nintedanib-induced entosis in prostate cancer cells occurred through phosphoinositide 3-kinase/cell division cycle 42 (CDC42) inhibition, followed by the upregulation of epithelial (E-)cadherin and components of the Rho kinase (ROCK) signaling pathway.	nintedanib	0-10	cadherin 1	Mus musculus	182-193
30867745-10	2019	In addition, in vivo treatment of mice xenografts with nintedanib also increased the expression of E-cadherin and components of the ROCK signaling pathway.	nintedanib	55-65	cadherin 1	Mus musculus	99-109
31057657-4	2019	CoCl2 treatment suppressed the expression of E-cadherin and elevated the expression of N-cadherin and Vimentin.	cobaltous chloride	0-5	cadherin 1	Mus musculus	45-55
30404020-1	2019	Extracellular Ca2+ (Ca2+o) is a crucial regulator of epidermal homeostasis and its receptor, the Ca2+-sensing receptor (CaSR), conveys the Ca2+o signals to promote keratinocyte adhesion, differentiation, and survival via activation of intracellular Ca2+ (Ca2+i) and E-cadherin-mediated signaling.	ca2+o	20-25	cadherin 1	Mus musculus	266-276
30404020-1	2019	Extracellular Ca2+ (Ca2+o) is a crucial regulator of epidermal homeostasis and its receptor, the Ca2+-sensing receptor (CaSR), conveys the Ca2+o signals to promote keratinocyte adhesion, differentiation, and survival via activation of intracellular Ca2+ (Ca2+i) and E-cadherin-mediated signaling.	ca2+o	139-144	cadherin 1	Mus musculus	266-276
30404020-1	2019	Extracellular Ca2+ (Ca2+o) is a crucial regulator of epidermal homeostasis and its receptor, the Ca2+-sensing receptor (CaSR), conveys the Ca2+o signals to promote keratinocyte adhesion, differentiation, and survival via activation of intracellular Ca2+ (Ca2+i) and E-cadherin-mediated signaling.	ca2+i	255-260	cadherin 1	Mus musculus	266-276
30404020-5	2019	Blocking the expression of CaSR or E-cadherin in cultured keratinocytes markedly inhibited the wound-induced Ca2+i propagation and their ability to migrate collectively.	ca2+i	109-114	cadherin 1	Mus musculus	35-45
30836660-9	2019	Furthermore, Sal administration significantly suppresses epithelial-mesenchymal transition (EMT), as evidenced by a decreased expression of alpha-SMA, vimentin, TGF-beta1, snail, slug, and a largely restored expression of E-cadherin.	rhodioloside	13-16	cadherin 1	Mus musculus	222-232
30517707-9	2019	At the same time, membrane levels of E-cadherin and beta-catenin were significantly decreased after TDI inhalation, which were inhibited by GSK2193874 or HC030031.	GSK2193874	140-150	cadherin 1	Mus musculus	37-47
30144073-6	2019	After treatment of shGRPR-1 and shGRPR-1 + LY294002, levels of urinary oxalate and urinary calcium in the serum, as well as positive rate of GRPR, became relatively low, levels of E-cadherin enhanced, whereas levels of Akt, PI3K, GRPR, extents of PI3K and Akt phosphorylation, alpha-SMA, Vimentin and FSP-1, OPN, MCP-1, and CD44 decreased and a number of crystals reduced.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	43-51	cadherin 1	Mus musculus	180-190
30770786-5	2019	E-cad is specifically localized to the cytomembrane of oocytes in PFs.	cytomembrane	39-51	cadherin 1	Mus musculus	0-5
30136377-9	2019	Bleomycin-induced lung fibrosis was associated with increased alpha smooth muscle actin (alpha-SMA) and decreased E-cadherin expression (P &lt; 0.01).	Bleomycin	0-9	cadherin 1	Mus musculus	114-124
30475349-3	2018	We engineered an oHSV to express CDH1, encoding E-cadherin, an adherent molecule and a ligand for KLRG1, an inhibitory receptor expressed on NK cells.	ohsv	17-21	cadherin 1	Mus musculus	33-37
30450674-9	2019	The addition of ATP attenuated CYT997-induced suppression of cell invasion, coupled with down-regulation of E-Cadherin and up-regulation of Vimentin.	Adenosine Triphosphate	16-19	cadherin 1	Mus musculus	108-118
30415774-11	2018	Additionally, the inhibition tumour cell infiltration and increase in E-cadherin expression were observed in xenografts of the mice orally administered with bLF.	CHEMBL2024323	157-160	cadherin 1	Mus musculus	70-80
30244166-0	2018	Andrographolide prevented toluene diisocyanate-induced occupational asthma and aberrant airway E-cadherin distribution via p38 MAPK-dependent Nrf2 induction.	andrographolide	0-15	cadherin 1	Mus musculus	95-105
30244166-10	2018	Mechanistically, the treatment prevented TDI-induced aberrant E-cadherin distribution and restored airway epithelial beta-catenin at cell to cell contact site.	Toluene 2,4-Diisocyanate	41-44	cadherin 1	Mus musculus	62-72
31245789-1	2019	In leptin-deficient ob/ob mice, obesity and diabetes are associated with abnormal development of neurocircuits in the hypothalamic arcuate nucleus (ARC)1, a critical brain area for energy and glucose homeostasis2,3.	Glucose	192-199	cadherin 1	Mus musculus	148-153
30708951-8	2019	Cirsiliol also suppressed the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (also known as Akt)/nuclear factor-kappaB (NF-kappaB) signaling pathway which, in turn, caused upregulation of E-cadherin and downregulation of N-cadherin, Snail and Twist.	cirsiliol	0-9	cadherin 1	Mus musculus	195-205
30567534-7	2018	The promoted 8-hydroxyoctanoic acid formation was also found to suppress the tumors" metastatic potential via regulating MMP-2 and E-cadherin expressions.	8-hydroxyoctanoic acid	13-35	cadherin 1	Mus musculus	131-141
30129057-7	2018	Crocin suppressed cell-growth and the invasive behavior of CRC cells through modulation of the Wnt-pathway and E-cadherin.	crocin	0-6	cadherin 1	Mus musculus	111-121
30475349-3	2018	We engineered an oHSV to express CDH1, encoding E-cadherin, an adherent molecule and a ligand for KLRG1, an inhibitory receptor expressed on NK cells.	ohsv	17-21	cadherin 1	Mus musculus	48-58
30061174-4	2018	Tamoxifen attenuated thickening of the peritoneum, and reversed PDF-induced peritoneal expression of E-cadherin, Vimentin, matrix metalloproteinase 9 (MMP9), Snail, and beta-catenin.	Tamoxifen	0-9	cadherin 1	Mus musculus	101-111
30524310-7	2018	Additionally, we provided in vivo evidence suggesting that OST repressed EMT with preserved E-cadherin and reduced Vimentin expression in obstructed kidney.	osthol	59-62	cadherin 1	Mus musculus	92-102
30257322-8	2018	Mechanistically, DHS modulated the expressions of several key metastasis regulating proteins e.g., MMP-2/9, N-cadherin, E-cadherin and survivin.	dhs	17-20	cadherin 1	Mus musculus	120-130
29484836-3	2018	Here, we describe and visualize that only 6 hr after cephalosporin treatment of mice, the Muc-2 mucus layer is reduced and E-cadherin junctions were altered.	Cephalosporins	53-66	cadherin 1	Mus musculus	123-133
30043283-13	2018	The protein expressions of Zonula occludens-1, E-cadherin, Claudin1 were decreased upon knocking down GPR35 with or without 1% DSS treatment.	Dextran Sulfate	127-130	cadherin 1	Mus musculus	47-57
29797576-7	2018	Expressions of Ki-67, VEGF, CD31, MMP2, MMP9, VCAM1, and NF-kappaB were significantly decreased in tumors from UMB-treated animals (P &lt; 0.001), whereas E-Cadherin and TNFR1 expressions were markedly increased (P &lt; 0.001).	umbelliprenin	111-114	cadherin 1	Mus musculus	155-165
29737515-8	2018	Our data showed that phytosomal curcumin and its combination with 5-FU inhibited cell growth and invasive behavior of CRC cells through modulation of Wnt-pathway and E-cadherin.	Curcumin	32-40	cadherin 1	Mus musculus	166-176
29737515-8	2018	Our data showed that phytosomal curcumin and its combination with 5-FU inhibited cell growth and invasive behavior of CRC cells through modulation of Wnt-pathway and E-cadherin.	Fluorouracil	66-70	cadherin 1	Mus musculus	166-176
30181244-6	2018	Treatment with the histone deacetylase (HDAC) inhibitor Pracinostat increased histone acetylation and restored CDH1 expression.	SB939 compound	56-67	cadherin 1	Mus musculus	111-115
29990528-7	2018	A low expression of hydroxyproline, vimentin, alpha-SMA, and Snail and a high expression of E-cadherin were found in FS-treated lungs compared with BLM-instilled lungs.	phenylalanylserine	117-119	cadherin 1	Mus musculus	92-102
29709678-6	2018	RESULTS: Cellular senescence, hypoxia, Abcb4-/- bile and chenodeoxycholic acid induced LOXL2 and SNAIL1 expression, repressed E-cadherin expression, and significantly reduced transepithelial electrical resistance in BECs.	Chenodeoxycholic Acid	57-78	cadherin 1	Mus musculus	126-136
29935167-7	2018	Abnormal DT epithelial cells in DBA/2Cr displayed elongated primary cilia, loose intercellular adhesions, and numerous vesicles with altered localization of CD9, Na+/K+ATPase, and E-cadherin, indicating altered cell function, adhesion, and polarity.	Thymidine	9-11	cadherin 1	Mus musculus	180-190
30015239-9	2018	Andrographolide intervention significantly reduced the expression of N-cadherin, alpha-SMA and vimentin (mesenchymal markers) and upregulated the expression of E-cadherin (an epithelial marker).	andrographolide	0-15	cadherin 1	Mus musculus	160-170
30032844-7	2018	Intragastric application of MK-2206 at a low dose (50 mg/kg) reversed the changes of the key indicators of EMT in the lungs of CS-exposed mice, including TGF-beta1, alpha-SMA, vimentin, MMP-9, MMP-2, S100A4, collagen deposition, and E-cadherin.	MK 2206	28-35	cadherin 1	Mus musculus	233-243
29480949-8	2018	Blockade of the MTNR1A receptor with luzindole in MN mice further impaired renal function; this was accompanied by CDH1 downregulation and Per2 and alphaSMA upregulation.	luzindole	37-46	cadherin 1	Mus musculus	115-119
29871974-9	2018	Nobiletin significantly altered the expression of PCNA, VEGF, and E-cadherin in ectopic endometrium, as well as the levels of IL-6, IL-1beta, TNF-alpha, MMP-1, and MMP-3.	nobiletin	0-9	cadherin 1	Mus musculus	66-76
29864937-10	2018	A549 cells were incubated with PQ plus FGF21 or PFD for 48 h. The results showed that FGF21 and PFD reduced the expression of TGF-beta, Col I and alpha-SMA and increased the expression of E-cadherin in PQ-treated A549 cells.	Paraquat	31-33	cadherin 1	Mus musculus	188-198
29581579-0	2018	Restoration of E-cadherin by PPBICA protects against cisplatin-induced acute kidney injury by attenuating inflammation and programmed cell death.	Cisplatin	53-62	cadherin 1	Mus musculus	15-25
29581579-4	2018	Here, we evaluated cell damage and inflammation in cisplatin-stimulated tubular epithelial cell lines after disrupting E-cadherin and restoring it with PPBICA, a small molecule identified by high-throughput screening.	Cisplatin	51-60	cadherin 1	Mus musculus	119-129
29581579-6	2018	Results show cisplatin reduced E-cadherin expression both in mouse kidney and proximal tubular epithelial cell lines (mTECs).	Cisplatin	13-22	cadherin 1	Mus musculus	31-41
29581579-13	2018	This was driven by restoration of E-cadherin in cisplatin nephropathy.	Cisplatin	48-57	cadherin 1	Mus musculus	34-44
28192889-8	2018	E-cadherin was higher in the cortices of groups III and IV compared to group I (p &amp;lt; 0.05).	Adenosine Monophosphate	83-86	cadherin 1	Mus musculus	0-10
29534875-0	2018	Esculetin suppresses tumor growth and metastasis by targeting Axin2/E-cadherin axis in colorectal cancer.	esculetin	0-9	cadherin 1	Mus musculus	68-78
29534875-6	2018	Here, esculetin (ES), a coumarin, was found to have the most potential effects on both beta-catenin-responsive transcriptional and E-cadherin promoter activities.	esculetin	6-15	cadherin 1	Mus musculus	131-141
29534875-6	2018	Here, esculetin (ES), a coumarin, was found to have the most potential effects on both beta-catenin-responsive transcriptional and E-cadherin promoter activities.	esculetin	17-19	cadherin 1	Mus musculus	131-141
29534875-6	2018	Here, esculetin (ES), a coumarin, was found to have the most potential effects on both beta-catenin-responsive transcriptional and E-cadherin promoter activities.	coumarin	24-32	cadherin 1	Mus musculus	131-141
29534875-8	2018	Mechanistically, Axin2 suppression by ES contributed to E-cadherin-mediated Wnt signaling inhibition.	esculetin	38-40	cadherin 1	Mus musculus	56-66
29534875-10	2018	Collectively, these findings suggest that targeting the Axin2/E-cadherin axis by ES may be an attractive therapeutic strategy for the treatment of metastatic CRC.	esculetin	81-83	cadherin 1	Mus musculus	62-72
29215110-9	2018	Quercetin also reversed E-cadherin expression, which is localized in normal proximal tubules in PKD mouse kidneys.	Quercetin	0-9	cadherin 1	Mus musculus	24-34
29567590-6	2018	Our data showed that azithromycin significantly reduced inflammation score, peribronchial smooth muscle layer thickness, goblet cell metaplasia, and deposition of collage fibers (P &lt; 0.05), and effectively suppressed airway EMT (upregulated E-cadherin level, and downregulated N-cadherin and alpha-SMA levels) compared with the OVA group (P &lt; 0.05).	Azithromycin	21-33	cadherin 1	Mus musculus	244-254
29725474-7	2018	However, E-cadherin was upregulated following TBG treatment.	telocinobufagin	46-49	cadherin 1	Mus musculus	9-19
29578124-0	2018	Role of glutamine in the mediation of E-cadherin, p120-catenin and inflammation in ventilator-induced lung injury.	Glutamine	8-17	cadherin 1	Mus musculus	38-48
29195901-6	2018	In addition, triptolide directly binds to TGFbeta and subsequently increase E-cadherin expression and decrease vimentin expression.	triptolide	13-23	cadherin 1	Mus musculus	76-86
29609658-9	2018	The results confirmed that the expression of the epithelial marker, E-cadherin, increased after SFN treatment, while expression of the mesenchymal markers, N-cadherin, vimentin, and alpha-SMA decreased in A549 cells after SFN treatment.	sulforaphane	96-99	cadherin 1	Mus musculus	68-78
29531814-7	2018	Herein, we demonstrate that 2-AP can restore E-cadherin expression and inhibit fibronectin and vimentin expression in TGF-beta1-treated A549 lung cancer cells.	2-Aminopurine	28-32	cadherin 1	Mus musculus	45-55
29169987-8	2018	Proliferative mammary epithelium from R-ketorolac-treated mice displayed greater differentiation, based on significantly higher total E-cadherin and decreased keratin 5 staining than epithelium of placebo-treated mice.	(R)-Ketorolac	38-49	cadherin 1	Mus musculus	134-144
29709917-7	2018	In colons from mice treated with 2.5% DSS for 10 d, epithelial damage was significantly enhanced by the depletion of CerK by day 5, whereas decreases in occluding and E-cadherin levels were similar in both mice.	dss	38-41	cadherin 1	Mus musculus	167-177
29805736-6	2018	A Wnt signaling inhibitor (XAV939) down-regulated invasion and the expression of ASCL2, beta-catenin, and vimentin but up-regulated E-cadherin expression.	XAV939	27-33	cadherin 1	Mus musculus	132-142
29742507-11	2018	Moreover, western blot and/or RT-PCR indicated that cleaved-caspase3 was enhanced and E-cadherin was inhibited by cyanidin treatment.	cyanidin	114-122	cadherin 1	Mus musculus	86-96
29652183-14	2018	We found that the number of vimentin and E-cadherin positive glomeruli and tubules were increased after sunitinib treatment compared to saline treated diabetic mice.	Sunitinib	104-113	cadherin 1	Mus musculus	41-51
29652183-17	2018	The effect of sunitinib on experimental diabetic mice appears to be related to levels of vimentin, E-cadherin and S100 in the glomeruli and tubules of the kidney, and sunitinib may protect against renal damage from DM.	Sunitinib	14-23	cadherin 1	Mus musculus	99-109
30522115-11	2018	The expression of Jagged1/Notch1/hes1/Snail1/alpha-SMA decreased, while the expression of E-cadherin increased in gliquidone-treated kidneys.	gliquidone	114-124	cadherin 1	Mus musculus	90-100
29115437-7	2018	Furthermore, simvastatin caused accumulations of the FOXO3a, E-cadherin, and p21 tumor suppressor proteins, which are downstream factors of MDM2, in HCT116 p53-/- cells.	Simvastatin	13-24	cadherin 1	Mus musculus	61-71
28656597-9	2017	Besides, in vivo assays demonstrated that rEhCP112 concentrates at the cellular borders of the mouse intestine degrading E-cad and Dsp I/II.	rehcp112	42-50	cadherin 1	Mus musculus	121-126
28992396-10	2017	However, colonic tissue and organoid staining exhibited an alcohol-induced significant decrease in cytokeratin 20+  (Krt20+) absorptive lineage enterocytes, a decrease in occludin and E-cadherin apical junction proteins, an increase in Chga, and an increase in the Lgr5 stem cell marker.	Alcohols	59-66	cadherin 1	Mus musculus	184-194
28893318-8	2017	RESULTS: In this study, we showed that ICG-001 significantly inhibited growth and metastasis of multiple GC cell lines, induced cell apoptosis, and augmented in vitro tumor spheres suppression when used in combination with chemotherapy drugs probably through robustly blocking association of beta-catenin with CBP and N-cadherin, but promoting association of beta-catenin with P300 and E-cadherin, instead of altering the distribution and expression of beta-catenin.	Indocyanine Green	39-42	cadherin 1	Mus musculus	386-396
29163781-6	2017	SYNJ2BP increased the levels of phosphorylation for AKT and GSK3beta, which could be inhibited by the PI3K inhibitor, LY294002, and the GSK3beta inhibitor, LiCl, and regulated the accumulation of SNAI1 in the nucleus and the expression of the SNAI1 target gene, E-cadherin (EMT marker).	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	118-126	cadherin 1	Mus musculus	262-272
29050211-8	2017	We assessed changes in E-cadherin, N-cadherin, and alpha-smooth muscle actin expression, and demonstrated that silibinin attenuates radiation-induced EMT.	Silybin	111-120	cadherin 1	Mus musculus	23-33
28739718-9	2017	The expression of E-cadherin was significantly higher in the VEGI174-treated group compared to the saline-treated group (p&lt;0.01).	Sodium Chloride	99-105	cadherin 1	Mus musculus	18-28
28795969-0	2017	E-cadherin Mediates the Preventive Effect of Vitamin D3 in Colitis-associated Carcinogenesis.	Cholecalciferol	45-55	cadherin 1	Mus musculus	0-10
28795969-8	2017	In vitro, vitamin D3 reduced the transcriptional activity and nuclear level of beta-catenin, and it also increased E-cadherin expression and its binding affinity for beta-catenin.	Cholecalciferol	10-20	cadherin 1	Mus musculus	115-125
28795969-9	2017	Moreover, repression of E-cadherin was rescued by supplemental vitamin D3 in mouse colons.	Cholecalciferol	63-73	cadherin 1	Mus musculus	24-34
28795969-11	2017	Our findings further suggest that upregulation of E-cadherin contributes to the preventive effect of vitamin D3 on beta-catenin activity.	Cholecalciferol	101-111	cadherin 1	Mus musculus	50-60
28831201-5	2017	Furthermore, BHX inhibited cell migration and invasion, which was associated with increased E-cadherin mRNA and protein expression, and down-regulation of SNAIL and vimentin.	(2s)-2-{[(S)-(2-Carboxyethyl)(Hydroxy)phosphoryl]methyl}pentanedioic Acid	13-16	cadherin 1	Mus musculus	92-102
28498365-4	2017	In addition, ectopic Chk2, as well as its (Chk2) induction by natural podophyllotoxin analog, 4"-demethyl-deoxypodophyllotoxin glucoside (4DPG), strongly restrain Twist1 activity along with other mesenchymal markers, for example, ZEB-1, vimentin and Snail1, whereas the epithelial markers such as E-cadherin and TIMP-1 expression augmented robustly.	Podophyllotoxin	70-85	cadherin 1	Mus musculus	297-307
28075049-7	2017	Again, either the M90-SHIP plasmid or the PI3K/Akt pathway inhibitor LY294002 could significantly prevent the high glucose-induced increase in TGF-beta1, alpha-SMA, and secreted Col 3 and decreased E-cadherin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	69-77	cadherin 1	Mus musculus	198-208
28075049-7	2017	Again, either the M90-SHIP plasmid or the PI3K/Akt pathway inhibitor LY294002 could significantly prevent the high glucose-induced increase in TGF-beta1, alpha-SMA, and secreted Col 3 and decreased E-cadherin.	Glucose	115-122	cadherin 1	Mus musculus	198-208
28498365-4	2017	In addition, ectopic Chk2, as well as its (Chk2) induction by natural podophyllotoxin analog, 4"-demethyl-deoxypodophyllotoxin glucoside (4DPG), strongly restrain Twist1 activity along with other mesenchymal markers, for example, ZEB-1, vimentin and Snail1, whereas the epithelial markers such as E-cadherin and TIMP-1 expression augmented robustly.	4"-demethyl	94-105	cadherin 1	Mus musculus	297-307
28498365-4	2017	In addition, ectopic Chk2, as well as its (Chk2) induction by natural podophyllotoxin analog, 4"-demethyl-deoxypodophyllotoxin glucoside (4DPG), strongly restrain Twist1 activity along with other mesenchymal markers, for example, ZEB-1, vimentin and Snail1, whereas the epithelial markers such as E-cadherin and TIMP-1 expression augmented robustly.	deoxypodophyllotoxin glucoside	106-136	cadherin 1	Mus musculus	297-307
28498365-4	2017	In addition, ectopic Chk2, as well as its (Chk2) induction by natural podophyllotoxin analog, 4"-demethyl-deoxypodophyllotoxin glucoside (4DPG), strongly restrain Twist1 activity along with other mesenchymal markers, for example, ZEB-1, vimentin and Snail1, whereas the epithelial markers such as E-cadherin and TIMP-1 expression augmented robustly.	4dpg	138-142	cadherin 1	Mus musculus	297-307
28615694-8	2017	Fluoxetine inhibits spreading of beta cells on E-cad/Fc coated slides and also disrupts E-cadherin-mediated actin filaments.	Fluoxetine	0-10	cadherin 1	Mus musculus	47-52
28329421-7	2017	Residual tumors excised from naproxen-treated animal were less invasive and showed reduced expression of epithelial-mesenchymal transition (EMT) markers N-cadherin, Vimentin, Snail and Twist with increased expression of E-cadherin.	Naproxen	29-37	cadherin 1	Mus musculus	220-230
28615694-0	2017	Selective serotonin reuptake inhibitor, fluoxetine, impairs E-cadherin-mediated cell adhesion and alters calcium homeostasis in pancreatic beta cells.	Fluoxetine	40-50	cadherin 1	Mus musculus	60-70
28615694-8	2017	Fluoxetine inhibits spreading of beta cells on E-cad/Fc coated slides and also disrupts E-cadherin-mediated actin filaments.	Fluoxetine	0-10	cadherin 1	Mus musculus	88-98
28615694-4	2017	This study aims to investigate whether a SSRI, fluoxetine (Prozac), induces pancreatic beta cell dysfunction through affecting E-cadherin and/or [Ca2+]i.	Fluoxetine	47-57	cadherin 1	Mus musculus	127-137
28615694-10	2017	These data suggest that exposure to fluoxetine results in impaired beta cell functions, occurring in concert with reduction of E-cadherin-dependent cell adhesion and alterations of calcium homeostasis.	Fluoxetine	36-46	cadherin 1	Mus musculus	127-137
28615694-4	2017	This study aims to investigate whether a SSRI, fluoxetine (Prozac), induces pancreatic beta cell dysfunction through affecting E-cadherin and/or [Ca2+]i.	Fluoxetine	59-65	cadherin 1	Mus musculus	127-137
28615694-7	2017	Immunofluorescence staining reveals that fluoxetine increases cytoplasmic accumulation of E-cadherin and reduces the membrane-localized E-cadherin probably due to increase of its endocytosis.	Fluoxetine	41-51	cadherin 1	Mus musculus	90-100
28615694-7	2017	Immunofluorescence staining reveals that fluoxetine increases cytoplasmic accumulation of E-cadherin and reduces the membrane-localized E-cadherin probably due to increase of its endocytosis.	Fluoxetine	41-51	cadherin 1	Mus musculus	136-146
28400057-8	2017	The exposure of 16HBE to TSLP resulted in redistribution of E-cadherin.	16hbe	16-21	cadherin 1	Mus musculus	60-70
28780788-9	2017	These changes were supported by decreased protein levels of alpha-SMA, Vimentin, Fibronectin, TGF-beta1 along with increased protein levels of E-cadherin in silica plus miR-489 group (P&lt;0.05) .	Silicon Dioxide	157-163	cadherin 1	Mus musculus	143-153
28428276-10	2017	Systemic administration of micelles carrying paclitaxel and rubone inhibited orthotopic prostate tumor growth in nude mice, compared with monotherapy, by reversing the expression of miR-34a, SIRT1, cyclin D1, and E-cadherin.	Paclitaxel	45-55	cadherin 1	Mus musculus	213-223
28428276-10	2017	Systemic administration of micelles carrying paclitaxel and rubone inhibited orthotopic prostate tumor growth in nude mice, compared with monotherapy, by reversing the expression of miR-34a, SIRT1, cyclin D1, and E-cadherin.	2'-hydroxy-2,4,4',5,6'-pentamethylchalcone	60-66	cadherin 1	Mus musculus	213-223
28376402-7	2017	In addition, cell migration and invasion were significantly suppressed by metapristone through down-regulating the expression of MMP-2, MMP-9, N-cadherin and vimentin, whereas up-regulating E-cadherin expression.	metapristone	74-86	cadherin 1	Mus musculus	190-200
28587416-7	2017	In addition, berberine significantly inhibited the increase of fluorescein isothiocyanate-dextran in serum and the decrease of zonula occluden-1 (also known as tight junction protein-1), occludin and epithelial cadherin expression in colonic tissue, relative to a DSS-treated control group.	Berberine	13-22	cadherin 1	Mus musculus	200-219
27573698-0	2016	Endogenously synthesized n-3 fatty acids in fat-1 transgenic mice prevent melanoma progression by increasing E-cadherin expression and inhibiting beta-catenin signaling.	Fatty Acids, Omega-3	25-40	cadherin 1	Mus musculus	109-119
28903339-6	2017	Furthermore, treatment with ZSTK474 or Niclosamide decreased protein level of EGFR, p-Akt, IL-6 and p-STAT3, and reversed ING5 knockdown-promoted EMT, as indicated by downregulated expression of EMT marker E-cadherin, an epithelial marker, increased expression of N-cadherin, a mesenchymal marker, and EMT-related transcription factors including Snail, Slug, Smad3 and Twist.	ZSTK474	28-35	cadherin 1	Mus musculus	206-216
28903339-6	2017	Furthermore, treatment with ZSTK474 or Niclosamide decreased protein level of EGFR, p-Akt, IL-6 and p-STAT3, and reversed ING5 knockdown-promoted EMT, as indicated by downregulated expression of EMT marker E-cadherin, an epithelial marker, increased expression of N-cadherin, a mesenchymal marker, and EMT-related transcription factors including Snail, Slug, Smad3 and Twist.	Niclosamide	39-50	cadherin 1	Mus musculus	206-216
28230093-5	2017	Furthermore, PBP abolished TGF-beta-mediated repression of E-cadherin expression, in addition to the induction of vimentin expression and N-cadherin and fibronectin upregulation, thus blocking TGF-beta-induced epithelial-mesenchymal transition in A549 and NMuMG cells.	pentabromophenol	13-16	cadherin 1	Mus musculus	59-69
28151481-3	2017	In bone metastasis of the 1833-xenograft model, DNA methyltransferase blockade using the chemotherapic drug 5-aza-2"-deoxycytidine (decitabine) strongly reduced the expression of HGF/Met receptor axis and of E-cadherin, with decrease of metastasis wideness and osteolysis, prolonging mice survival.	Decitabine	108-130	cadherin 1	Mus musculus	208-218
28151481-3	2017	In bone metastasis of the 1833-xenograft model, DNA methyltransferase blockade using the chemotherapic drug 5-aza-2"-deoxycytidine (decitabine) strongly reduced the expression of HGF/Met receptor axis and of E-cadherin, with decrease of metastasis wideness and osteolysis, prolonging mice survival.	Decitabine	132-142	cadherin 1	Mus musculus	208-218
27888538-6	2017	Moreover, the relative intensity of N-cadherin versus E-cadherin increased 2.6-fold, and the E-cadherin distribution in cell-cell junctions became jagged and faint after EGF incubation for 72 h. Interestingly, the amounts of bisecting GlcNAc structure were dramatically declined, by contrast, the formation of beta1,6 GlcNAc branches on cell surface was upregulated during EMT induced by EGF.	2-acetamido-2-deoxy-4-O-(beta-2-acetamid-2-deoxyglucopyranosyl)glucopyranose	235-241	cadherin 1	Mus musculus	93-103
27888538-6	2017	Moreover, the relative intensity of N-cadherin versus E-cadherin increased 2.6-fold, and the E-cadherin distribution in cell-cell junctions became jagged and faint after EGF incubation for 72 h. Interestingly, the amounts of bisecting GlcNAc structure were dramatically declined, by contrast, the formation of beta1,6 GlcNAc branches on cell surface was upregulated during EMT induced by EGF.	beta1,6 glcnac	310-324	cadherin 1	Mus musculus	93-103
28966242-0	2017	The Role of E-Cadherin/beta-Catenin in Hydroxysafflor Yellow A Inhibiting Adhesion, Invasion, Migration and Lung Metastasis of Hepatoma Cells.	hydroxysafflor yellow A	39-62	cadherin 1	Mus musculus	12-22
27602499-9	2016	Further, qPCR analysis revealed significant alterations in the expression of Twist and E-cadherin in lungs of Mcpt5-Cre+ R-DTA+ vs. control Mcpt5-Cre- R-DTA+ animals, suggesting an impact of mast cells on epithelial-mesenchymal transition.	deoxythymidylyl-3'-5'-deoxyadenylate	123-126	cadherin 1	Mus musculus	87-97
27602499-9	2016	Further, qPCR analysis revealed significant alterations in the expression of Twist and E-cadherin in lungs of Mcpt5-Cre+ R-DTA+ vs. control Mcpt5-Cre- R-DTA+ animals, suggesting an impact of mast cells on epithelial-mesenchymal transition.	deoxythymidylyl-3'-5'-deoxyadenylate	153-156	cadherin 1	Mus musculus	87-97
26956696-6	2016	High glucose (HG)/hypoxic conditions stimulated EMT in renal tubular cells as indicated by the significant decrease in epithelial marker E-cadherin and ZO-1 while the increase in mesenchymal markers alpha-smooth muscle actin (alpha-SMA).	Glucose	5-12	cadherin 1	Mus musculus	137-147
30650503-8	2017	Protein and mRNA expressions of N-cadherin, Snail, p-PI3K, p-AKT decreased, and protein and mRNA expressions of E-cadherin increased in 5-FU group and beta-asarone groups (P &lt; 0.	asarone	151-163	cadherin 1	Mus musculus	112-122
27912077-10	2017	In vivo, the DDC-stimulated number of cytokeratin-19-positive cells in the liver of wild-type animals was slightly reduced in Nlrp3-/- mice, and expression of E-cadherin was reestablished.	3,5-diethoxycarbonyl-1,4-dihydrocollidine	13-16	cadherin 1	Mus musculus	159-169
28077049-4	2017	Through Lewis tumor-bearing C57BL/6 mouse model, carboxymethyl-chitosan was proved to be able to inhibit solid tumor growth and tumor metastasis to the liver and lung, meanwhile increase the level of tissue inhibitor of metalloproteinase 1 and E-cadherin, and decrease the level of mice blood serum matrix metalloproteinase 9.	carboxymethyl-chitosan	49-71	cadherin 1	Mus musculus	244-254
27533452-5	2016	Accordingly, overexpression of MGAT5-mediated branched N-glycans both in gastric cancer cells and transgenic mice models led to a significant decrease of O-mannosyl glycans attached to E-cadherin that was associated with impairment of its tumour suppressive functions.	branched n-glycans	46-64	cadherin 1	Mus musculus	185-195
27533452-5	2016	Accordingly, overexpression of MGAT5-mediated branched N-glycans both in gastric cancer cells and transgenic mice models led to a significant decrease of O-mannosyl glycans attached to E-cadherin that was associated with impairment of its tumour suppressive functions.	o-mannosyl glycans	154-172	cadherin 1	Mus musculus	185-195
27557515-8	2016	It is worth noting that aspirin down-regulated ribosome biogenesis, stabilized p53 and up-regulated E-cadherin expression in unstimulated control cells also.	Aspirin	24-31	cadherin 1	Mus musculus	100-110
27573203-7	2016	Results showed that curcumin decreased E-cadherin, N-cadherin, beta-catenin, Slug, AXL, Twist1, Vimentin and Fibronectin protein expression, independently of the positivity of the markers in the cell lines.	Curcumin	20-28	cadherin 1	Mus musculus	39-49
27017346-12	2016	Quercitrin treatment also increased the expression of E-cadherin, and PD98059 abrogated the upregulation of E-cadherin induced by quercitrin.	quercitrin	0-10	cadherin 1	Mus musculus	54-64
26778638-0	2016	Overexpression of Bcl-2, SOCS 1, 3 and Cdh 1, 2 are associated with the early neoplasic changes in modified 4-nitroquinoline 1-oxide-induced murine oral cancer model.	4-Nitroquinoline-1-oxide	108-132	cadherin 1	Mus musculus	39-44
26778638-8	2016	CONCLUSIONS: Together, the results suggested that overexpression of Bcl-2, SOCS 1 and 3, and Cdh 1 and 2 is associated with the early neoplasic changes in modified 4-nitroquinoline 1-oxide-induced murine oral cancer model.	4-Nitroquinoline-1-oxide	164-188	cadherin 1	Mus musculus	93-104
27574508-8	2016	Sodium propionate significantly inhibited the increase of FITC-dextran in serum and the decrease of zonula occludens-1 (ZO-1), occludin, and E-cadherin expression in the colonic tissue.	sodium propionate	0-17	cadherin 1	Mus musculus	141-151
27525306-9	2016	Finally, in the experimental mouse model, we showed that curcumin inhibited HGF-stimulated tumor growth and induced an increase in E-cadherin expression and a decrease in vimentin, CD34, and vascular endothelial growth factor (VEGF) expression.	Curcumin	57-65	cadherin 1	Mus musculus	131-141
27279470-8	2016	The protein levels of Vimentin and phospho-SMAD2 were upregulated, whereas the level of E-cadherin was downregulated in the MCMV+bleomycin group,.	Bleomycin	129-138	cadherin 1	Mus musculus	88-98
27017346-12	2016	Quercitrin treatment also increased the expression of E-cadherin, and PD98059 abrogated the upregulation of E-cadherin induced by quercitrin.	quercitrin	0-10	cadherin 1	Mus musculus	108-118
27017346-12	2016	Quercitrin treatment also increased the expression of E-cadherin, and PD98059 abrogated the upregulation of E-cadherin induced by quercitrin.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	70-77	cadherin 1	Mus musculus	108-118
27017346-12	2016	Quercitrin treatment also increased the expression of E-cadherin, and PD98059 abrogated the upregulation of E-cadherin induced by quercitrin.	quercitrin	130-140	cadherin 1	Mus musculus	108-118
26154024-6	2016	Moreover, amarogentin could up-regulate E-cadherin expression and down-regulate expression of EGFR in the liver lesions.	amarogentin	10-21	cadherin 1	Mus musculus	40-50
27133302-7	2016	RESULTS: In PF mice, paeoniflorin (50, 100 mg kg(-1) d(-1)) or prednisone (6 mg kg(-1) d(-1)) significantly decreased the expression of FSP-1 and alpha-SMA, and increased the expression of E-cadherin in lung tissues.	peoniflorin	21-33	cadherin 1	Mus musculus	189-199
27133302-7	2016	RESULTS: In PF mice, paeoniflorin (50, 100 mg kg(-1) d(-1)) or prednisone (6 mg kg(-1) d(-1)) significantly decreased the expression of FSP-1 and alpha-SMA, and increased the expression of E-cadherin in lung tissues.	Prednisone	63-73	cadherin 1	Mus musculus	189-199
27188605-11	2016	CONCLUSIONS: Administration of imrecoxib combined with lobaphatin has inhibitory effects on the growth of non-small cell lung cancer xenografts and lymph node metastasis via down-regulated ezrin and upregulated E-cadherin.	Imrecoxib	31-40	cadherin 1	Mus musculus	211-221
27262076-0	2016	Experiment research of cisplatin implants inhibiting transplantation tumor growth and regulating the expression of KLK7 and E-cad of tumor-bearing mice with gastric cancer.	Cisplatin	23-32	cadherin 1	Mus musculus	124-129
27262076-7	2016	CONCLUSION: Cisplatin implants can inhibit the growth of transplanted tumor tissue and down-regulated KLK7 expression and up-regulated E-cad expression of tumor-bearing mice with gastric cancer.	Cisplatin	12-21	cadherin 1	Mus musculus	135-140
26957367-9	2016	We further demonstrated that migration of ALCs was inhibited in vitro and that E-cadherin expression was significantly up-regulated when ALCs were treated with the beta-catenin inhibitor, ICG-001.	Indocyanine Green	188-191	cadherin 1	Mus musculus	79-89
27188605-11	2016	CONCLUSIONS: Administration of imrecoxib combined with lobaphatin has inhibitory effects on the growth of non-small cell lung cancer xenografts and lymph node metastasis via down-regulated ezrin and upregulated E-cadherin.	lobaphatin	55-65	cadherin 1	Mus musculus	211-221
26808085-8	2016	In vivo experiments revealed that the treatment of 8-MOP (5 or 20mg/kg) resulted in a dose-dependent decreases in the lung metastasis of hepatoma H22-transplanted mice without any obvious toxicity to the organs, as well as increased expression of E-cadherin in lung tissues.	Methoxsalen	51-56	cadherin 1	Mus musculus	247-257
27249616-5	2016	Moreover, resveratrol also inhibited the BLM-induced EMT-associated molecular events, such as reduced E-cadherin and elevated Collagen I and alpha-SMA.	Resveratrol	10-21	cadherin 1	Mus musculus	102-112
27249616-5	2016	Moreover, resveratrol also inhibited the BLM-induced EMT-associated molecular events, such as reduced E-cadherin and elevated Collagen I and alpha-SMA.	Bleomycin	41-44	cadherin 1	Mus musculus	102-112
26845617-11	2016	These results provide a new mechanism by which LXA4 inhibits LPS-induced ALI through Nrf2-mediated E-cadherin expression.	lipoxin A4	47-51	cadherin 1	Mus musculus	99-109
27058323-7	2016	The up-regulation of self renewal Wnt/beta-catenin, Hh/Gli1 pathways and their associated genes Cyclin D1, cMyc and EGFR along with down regulation of E-cadherin seen during the carcinogenesis processes were found to be modulated during the restriction processes by EGCG/TF.	epigallocatechin gallate	266-270	cadherin 1	Mus musculus	151-161
26963473-8	2016	Real-time PCR identified significant DHT-dependent changes in the concentrations of mRNAs encoded by genes implicated in the regulation of the cell cycle (Wee1, Ccnd1, Rb1) and stromal-epithelial interactions (Wnt4, Wnt5a, Wnt7a, Cdh1, Vcl, Igf1, Prl8, Prlr) as well as a striking effect on the number of endometrial glands.	Dihydrotestosterone	37-40	cadherin 1	Mus musculus	230-234
27143932-10	2016	Moreover, we found the vitamin D3 increased the expression of E-cadherin and vitamin D receptor while it decreased the expression of beta-catenin.	Cholecalciferol	23-33	cadherin 1	Mus musculus	62-72
26721332-11	2016	The gross morphology of colonic mucosa was unaltered, but ethanol disrupted the actin cytoskeleton, induced redistribution of occludin, ZO-1, E-cadherin and beta-catenin from the junctions and elevated TLR4, which was more severe in Ocln(-/-) mice.	Ethanol	58-65	cadherin 1	Mus musculus	142-152
27516188-4	2016	We found in liver samples from iron-overloaded mice that the apparent molecular mass of E-cad was reduced from 125 to 115 kDa in sodium dodecyl sulphate polyacrylamide gel electrophoresis under reducing conditions and immunoblotting, and that the cellular expression of E-cad was decreased in immunohistochemistry.	polyacrylamide	153-167	cadherin 1	Mus musculus	88-93
26859835-4	2016	In lung tissues of bleomycin-treated mice, HSP27 was strongly upregulated and substantially co-localized with alpha-SMA, OPN and type I collagen but not with proSP-C (a marker of type II alveolar epithelial cells), E-cadherin (a marker of epithelial cells) or F4/80 (a marker of macrophages).	Bleomycin	19-28	cadherin 1	Mus musculus	215-225
26793111-8	2015	Moreover, celastrol obviously suppressed epithelial-mesenchymal transition (EMT) through up-regulating E-cadherin and down-regulating N-cadherin, Vimentin and Snail.	celastrol	10-19	cadherin 1	Mus musculus	103-113
26598521-5	2016	Mutation of the five modified Runx1 tyrosines to aspartate markedly reduced co-immunoprecipitation with HDAC1 and HDAC3, markedly increased stability in cycloheximide or in the presence of co-expressed Cdh1, an E3 ubiquitin ligase coactivator, with reduced ubiquitination, and allowed DNA-binding in gel shift assay similar to wild-type Runx1.	Tyrosine	36-45	cadherin 1	Mus musculus	202-206
26598521-5	2016	Mutation of the five modified Runx1 tyrosines to aspartate markedly reduced co-immunoprecipitation with HDAC1 and HDAC3, markedly increased stability in cycloheximide or in the presence of co-expressed Cdh1, an E3 ubiquitin ligase coactivator, with reduced ubiquitination, and allowed DNA-binding in gel shift assay similar to wild-type Runx1.	Aspartic Acid	49-58	cadherin 1	Mus musculus	202-206
27516188-0	2016	Iron Overload Causes Alterations of E-Cadherin in the Liver.	Iron	0-4	cadherin 1	Mus musculus	36-46
27516188-4	2016	We found in liver samples from iron-overloaded mice that the apparent molecular mass of E-cad was reduced from 125 to 115 kDa in sodium dodecyl sulphate polyacrylamide gel electrophoresis under reducing conditions and immunoblotting, and that the cellular expression of E-cad was decreased in immunohistochemistry.	Iron	31-35	cadherin 1	Mus musculus	88-93
27516188-4	2016	We found in liver samples from iron-overloaded mice that the apparent molecular mass of E-cad was reduced from 125 to 115 kDa in sodium dodecyl sulphate polyacrylamide gel electrophoresis under reducing conditions and immunoblotting, and that the cellular expression of E-cad was decreased in immunohistochemistry.	Iron	31-35	cadherin 1	Mus musculus	270-275
27516188-4	2016	We found in liver samples from iron-overloaded mice that the apparent molecular mass of E-cad was reduced from 125 to 115 kDa in sodium dodecyl sulphate polyacrylamide gel electrophoresis under reducing conditions and immunoblotting, and that the cellular expression of E-cad was decreased in immunohistochemistry.	Sodium Dodecyl Sulfate	129-152	cadherin 1	Mus musculus	88-93
27516188-8	2016	Treatment of the 115 kDa E-cad with deferoxamine, an iron chelator, thus removing Fe2+, shifted the molecular mass back to 125 kDa, demonstrating that the shift is reversible.	Deferoxamine	36-48	cadherin 1	Mus musculus	25-30
27516188-8	2016	Treatment of the 115 kDa E-cad with deferoxamine, an iron chelator, thus removing Fe2+, shifted the molecular mass back to 125 kDa, demonstrating that the shift is reversible.	Iron	53-57	cadherin 1	Mus musculus	25-30
27516188-8	2016	Treatment of the 115 kDa E-cad with deferoxamine, an iron chelator, thus removing Fe2+, shifted the molecular mass back to 125 kDa, demonstrating that the shift is reversible.	ammonium ferrous sulfate	82-86	cadherin 1	Mus musculus	25-30
27516188-11	2016	The alteration of E-cad that causes the mobility shift might be an initial step to liver diseases by iron overload.	Iron	101-105	cadherin 1	Mus musculus	18-23
26703648-7	2015	In vivo studies performed in ovariectomized, female nude mice indicated that glyceollin treated tumors stained weakly for ZEB1 and N-cadherin and strongly for E-cadherin.	glyceollin	77-87	cadherin 1	Mus musculus	159-169
26548461-12	2016	The mRNA expression of mesenchymal markers N-cadherin, vimentin, snail and twist decreased, while expression of epithelial marker E-cadherin increased in hepa1-6 cells after treated with ATRA.	Tretinoin	187-191	cadherin 1	Mus musculus	130-140
26454701-8	2015	Our results showed that celastrol treatment ameliorated the severity of colitis, decreased the level of interleukin (IL)-1beta, IL-6 and myeloperoxidase (MPO) and upregulated the level of E-cadherin in colitis mice.	celastrol	24-33	cadherin 1	Mus musculus	188-198
27051948-0	2015	[Preliminary study on E-cadherin expression in dexamethasone-induced palatal cleft in mouse].	Dexamethasone	47-60	cadherin 1	Mus musculus	22-32
27051948-4	2015	This study aimed to determine whether the change in E-cadherin expression is related to the incidence of cleft palate in DEX-induced mice.	Dexamethasone	121-124	cadherin 1	Mus musculus	52-62
27051948-12	2015	CONCLUSION: These findings indicated that DEX could induce E-cadherin gene upregulation and ectopic expression, as well as high beta-catenin expression, thereby inhibiting the growth of mesenchyme cells and cleft palate.	Dexamethasone	42-45	cadherin 1	Mus musculus	59-69
26491358-11	2015	In the estrogen plus tamoxifen group, protein and mRNA expressions of ERalpha and AKT were dramatically reduced by tamoxifen treatment in tumor tissue compared with the estrogen group; mRNA expression of E-cadherin was increased in tumor tissue; protein expression of vimentin and PI3K were downregulated in tumor tissue; protein expression of E-cadherin increased in lung tissue; protein expression of ERalpha and PI3K were downregulated in lung tissue compared with the estrogen group.	Tamoxifen	21-30	cadherin 1	Mus musculus	204-214
26597177-14	2015	Treatment of FLP in combination with celecoxib was more effective than FLP or celecoxib alone in inhibiting vascular endothelial growth factor, platelet-derived growth factor receptors beta, microsomal Prostaglandin E synthase-1, MMP-2, MMP-9, N-cadherin, and Vimentin expression, but increased E-cadherin expression.	Celecoxib	37-46	cadherin 1	Mus musculus	295-305
26352004-11	2015	Accordingly, GdCl3 treatment increased the expression of the epithelial-mesenchymal transition (EMT)-related protein E-cadherin while expression of N-cadherin, TWIST and Snail was reduced in IL-4-stimulated cells.	gadolinium chloride	13-18	cadherin 1	Mus musculus	117-127
26474281-5	2015	6-OAP bound Skp1 at sites critical to Skp1-Skp2 interaction, leading to dissociation and proteolysis of oncogenic E3 ligases NIPA, Skp2, and beta-TRCP, and accumulation of their substrates Cyclin B1, P27 and E-Cadherin.	OAP protocol	2-5	cadherin 1	Mus musculus	208-218
26192163-7	2015	8-Bromo cAMP induced myosin light chain phosphorylation through Rac1 and Cdc42 signaling, which were involved in 8-Bromo cAMP-induced decrease in expression of junction proteins (connexin 43, E-cadherin, and occludin) at the plasma membrane.	8-bromo	0-7	cadherin 1	Mus musculus	192-202
26192163-7	2015	8-Bromo cAMP induced myosin light chain phosphorylation through Rac1 and Cdc42 signaling, which were involved in 8-Bromo cAMP-induced decrease in expression of junction proteins (connexin 43, E-cadherin, and occludin) at the plasma membrane.	Cyclic AMP	8-12	cadherin 1	Mus musculus	192-202
26192163-7	2015	8-Bromo cAMP induced myosin light chain phosphorylation through Rac1 and Cdc42 signaling, which were involved in 8-Bromo cAMP-induced decrease in expression of junction proteins (connexin 43, E-cadherin, and occludin) at the plasma membrane.	8-bromo	113-120	cadherin 1	Mus musculus	192-202
26192163-7	2015	8-Bromo cAMP induced myosin light chain phosphorylation through Rac1 and Cdc42 signaling, which were involved in 8-Bromo cAMP-induced decrease in expression of junction proteins (connexin 43, E-cadherin, and occludin) at the plasma membrane.	Cyclic AMP	121-125	cadherin 1	Mus musculus	192-202
26491358-11	2015	In the estrogen plus tamoxifen group, protein and mRNA expressions of ERalpha and AKT were dramatically reduced by tamoxifen treatment in tumor tissue compared with the estrogen group; mRNA expression of E-cadherin was increased in tumor tissue; protein expression of vimentin and PI3K were downregulated in tumor tissue; protein expression of E-cadherin increased in lung tissue; protein expression of ERalpha and PI3K were downregulated in lung tissue compared with the estrogen group.	Tamoxifen	21-30	cadherin 1	Mus musculus	344-354
26491358-11	2015	In the estrogen plus tamoxifen group, protein and mRNA expressions of ERalpha and AKT were dramatically reduced by tamoxifen treatment in tumor tissue compared with the estrogen group; mRNA expression of E-cadherin was increased in tumor tissue; protein expression of vimentin and PI3K were downregulated in tumor tissue; protein expression of E-cadherin increased in lung tissue; protein expression of ERalpha and PI3K were downregulated in lung tissue compared with the estrogen group.	Tamoxifen	115-124	cadherin 1	Mus musculus	204-214
26491358-11	2015	In the estrogen plus tamoxifen group, protein and mRNA expressions of ERalpha and AKT were dramatically reduced by tamoxifen treatment in tumor tissue compared with the estrogen group; mRNA expression of E-cadherin was increased in tumor tissue; protein expression of vimentin and PI3K were downregulated in tumor tissue; protein expression of E-cadherin increased in lung tissue; protein expression of ERalpha and PI3K were downregulated in lung tissue compared with the estrogen group.	Tamoxifen	115-124	cadherin 1	Mus musculus	344-354
26491358-14	2015	In the estrogen plus tamoxifen group, tamoxifen treatment dramatically reduced protein expression of ERalpha, ERbeta, AKT, and vimentin but significantly increased protein expression of E-cadherin in tumor tissues and lung tissue compared with the estrogen group.	Tamoxifen	21-30	cadherin 1	Mus musculus	186-196
26491358-14	2015	In the estrogen plus tamoxifen group, tamoxifen treatment dramatically reduced protein expression of ERalpha, ERbeta, AKT, and vimentin but significantly increased protein expression of E-cadherin in tumor tissues and lung tissue compared with the estrogen group.	Tamoxifen	38-47	cadherin 1	Mus musculus	186-196
26101798-8	2015	The alterations in E-cadherin, IFN-gamma, IL-6 and IL-10 were associated with OC, TC and some amino acids, particularly non-protein-type amino acids.	Technetium	82-84	cadherin 1	Mus musculus	19-29
26487802-13	2015	We found that As4S4 upregulated the expression of E-cadherin and downregulated the expression of beta-catenin, Sp1, VEGF, and CD34 in mouse tumor tissues, consistent with the results in vitro.	as4s4	14-19	cadherin 1	Mus musculus	50-60
26240067-7	2015	Reduction in E-cadherin synergised with an activating mutation of beta-catenin resulting in a rapid CPC phenotype within the SI and colon.	cpc	100-103	cadherin 1	Mus musculus	13-23
26622703-0	2015	Metformin upregulates E-cadherin and inhibits B16F10 cell motility, invasion and migration.	Metformin	0-9	cadherin 1	Mus musculus	22-32
26183215-11	2015	Molecular analysis showed reduced MIF expression and increased E-cadherin mRNA expression in the colon of sulindac-treated Hif1alpha(DeltaIEC) mice.	Sulindac	106-114	cadherin 1	Mus musculus	63-73
26183215-12	2015	However, immunohistochemistry analysis revealed a defect of E-cadherin protein expression in sulindac-treated Hif1alpha(DeltaIEC) mice.	Sulindac	93-101	cadherin 1	Mus musculus	60-70
26183215-14	2015	Taken together, HIF1alpha expression augments inflammation in the proximal colon of sulindac-treated mice, and AHR activation by sulindac might lead to the reduction of E-cadherin protein levels through the mitogen-activated protein kinase (MAPK) pathway.	Sulindac	84-92	cadherin 1	Mus musculus	169-179
26183215-14	2015	Taken together, HIF1alpha expression augments inflammation in the proximal colon of sulindac-treated mice, and AHR activation by sulindac might lead to the reduction of E-cadherin protein levels through the mitogen-activated protein kinase (MAPK) pathway.	Sulindac	129-137	cadherin 1	Mus musculus	169-179
26329581-7	2015	Knocking down Cdh1 in melanoma cells in culture or before implantation in mice promoted doxorubicin resistance, whereas reexpressing wild-type Cdh1, but not E3 ligase-deficient Cdh1 or a mutant that could not interact with PAX3, restored doxorubicin sensitivity in melanoma cells both in culture and in xenografts.	Doxorubicin	88-99	cadherin 1	Mus musculus	14-18
26329581-7	2015	Knocking down Cdh1 in melanoma cells in culture or before implantation in mice promoted doxorubicin resistance, whereas reexpressing wild-type Cdh1, but not E3 ligase-deficient Cdh1 or a mutant that could not interact with PAX3, restored doxorubicin sensitivity in melanoma cells both in culture and in xenografts.	Doxorubicin	238-249	cadherin 1	Mus musculus	14-18
26622703-7	2015	The results showed that metformin effectively upregulated the expression of E-cadherin, and inhibited B16F10 cell motility, migration and invasion, in a dose-dependent manner.	Metformin	24-33	cadherin 1	Mus musculus	76-86
26622703-8	2015	This suggested that the inhibition of motility, migration and invasion of B16F10 cells by metformin may be associated with the upregulation of E-cadherin expression, indicating that metformin may have a role in the treatment of melanoma.	Metformin	90-99	cadherin 1	Mus musculus	143-153
26622703-8	2015	This suggested that the inhibition of motility, migration and invasion of B16F10 cells by metformin may be associated with the upregulation of E-cadherin expression, indicating that metformin may have a role in the treatment of melanoma.	Metformin	182-191	cadherin 1	Mus musculus	143-153
25892252-10	2015	These data suggested that isoflurane inhibits self-renewal and neuronal differentiation of mES cells, possibly by regulating the miR-9-E-cadherin signaling.	2-(N-morpholino)ethanesulfonic acid	91-94	cadherin 1	Mus musculus	135-145
26089345-8	2015	Treatment with LY294002 rescued the distribution of E-cadherin and beta-catenin at cell-cell membranes, restored total beta-catenin pool, but had no effect on protein level of E-cadherin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	15-23	cadherin 1	Mus musculus	52-62
25818617-8	2015	Cells treated concurrently with TGF-beta1 and geniposide retained high levels of localized E-cadherin expression with no increase in vimentin.	geniposide	46-56	cadherin 1	Mus musculus	91-101
26226941-2	2015	Here we show that E-cadherin overexpression in Raw 264.7 macrophages inhibits their inflammatory response to LPS stimulation, as demonstrated by a reduced secretion of inflammatory mediators like interleukin (IL)-6, tumor necrosis factor (TNF) and nitric oxide (NO).	Nitric Oxide	248-260	cadherin 1	Mus musculus	18-28
26085088-3	2015	Indeed, both decitabine(R) and PKC412(R) displayed the up-regulation of DNA methyltransferase DNMT1 and tyrosine-protein kinase KIT, the enhanced phosphorylation of KIT and its downstream effectors, and the increased global and gene-specific DNA methylation with the down-regulation of tumor suppressor gene epithelial cadherin CDH1.	Decitabine	13-23	cadherin 1	Mus musculus	328-332
26085088-6	2015	Importantly, when engrafted into nude mice, decitabine(R) and PKC412(R) had faster proliferation with stronger tumorigenicity that was caused by the reactivated KIT kinase signaling and further CDH1 silencing.	Decitabine	44-54	cadherin 1	Mus musculus	194-198
25892252-0	2015	Isoflurane Inhibits Embryonic Stem Cell Self-Renewal and Neural Differentiation Through miR-9/E-cadherin Signaling.	Isoflurane	0-10	cadherin 1	Mus musculus	94-104
25892252-5	2015	Overexpression of E-cadherin attenuated the effects of isoflurane on self-renewal and the subsequent neuronal differentiation.	Isoflurane	55-65	cadherin 1	Mus musculus	18-28
25892252-9	2015	Overexpression of E-cadherin can abolish the function of miR-9 or isoflurane on self-renewal and subsequent neuronal differentiation.	Isoflurane	66-76	cadherin 1	Mus musculus	18-28
25892252-10	2015	These data suggested that isoflurane inhibits self-renewal and neuronal differentiation of mES cells, possibly by regulating the miR-9-E-cadherin signaling.	Isoflurane	26-36	cadherin 1	Mus musculus	135-145
25957791-9	2015	After 9 days of in vitro testosterone-BSA treatment, more Edu(+), Sox2(+), and HCLC cells were observed in the LER with an accompanying downregulation of E-cadherin.	Testosterone	25-37	cadherin 1	Mus musculus	154-164
25998793-9	2015	The results revealed that the mice treated with 1,25(OH)2D3 displayed decreased airway hyperresponsiveness (AHR), suppressed neutrophil and eosinophil infiltration into the airways, as well as an increased E-cadherin and zonula occludens-1 (ZO-1) expression at the cell-cell contact sites.	Calcitriol	48-59	cadherin 1	Mus musculus	206-216
25998793-10	2015	In vitro, exposure of the cells to TDI-HSA induced a rapid decline in transepithelial electrical resistance (TER) and an increase in cell permeability, followed by a decrease in occludin expression and the redistribution of E-cadherin, accompanied by a significant upregulation in the levels of phosphorylated extracellular signal-regulated kinase (ERK)1/2.	tdi-hsa	35-42	cadherin 1	Mus musculus	224-234
25892014-5	2015	However, treatment with 5-aza-2"-deoxycytidine attenuated the TGF-beta1-induced downregulation of KLF4 and E-cadherin and the upregulation of alpha-smooth muscle actin (alpha-SMA) in the HK-2 cells.	Decitabine	24-46	cadherin 1	Mus musculus	107-117
25986488-10	2015	However, the altered levels of occludin and E-cadherin were reversed by PP2 or Y27632 treatments compared with the cyclic stretch group.	Y 27632	79-85	cadherin 1	Mus musculus	44-54
25697583-4	2015	The results showed that the protein expression levels of E-cad and Pan-ck were lower, and the protein expression levels of alpha-SMA and Vim were higher, in the kidney tissue of the glyoxylate induced model mice compared with the control mice.	glyoxylic acid	182-192	cadherin 1	Mus musculus	57-62
25895672-11	2015	Induction of autophagy by spermidine influenced the epithelial induction of E-cadherin and vimentin that was blocked by treating astragalin.	Spermidine	26-36	cadherin 1	Mus musculus	76-86
25634675-0	2015	Intestinal E-cadherin Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis.	dextran sodium sulfate	44-66	cadherin 1	Mus musculus	11-21
25634675-7	2015	RESULTS: E-cadherin deficiency in the adult mouse intestinal epithelium aggravates the clinical and histological features of DSS-induced colitis.	dss	125-128	cadherin 1	Mus musculus	9-19
25634675-8	2015	Upon DSS treatment, mice deficient in E-cadherin lost more weight, were more severely dehydrated, and showed more frequently blood in the feces.	dss	5-8	cadherin 1	Mus musculus	38-48
26097536-2	2015	We have previously demonstrated that extracellular calcium promotes keratinocyte differentiation via E-cadherin-catenin complex-mediated phospholipase C-gamma1 (PLC-gamma1) activation in the plasma membrane.	Calcium	51-58	cadherin 1	Mus musculus	101-111
26097536-10	2015	Increased E-cadherin, beta-catenin, p120 and EGFR and decreased PLC-gamma1 may participate in the inhibitory effect of dietary calcium in oral carcinogenesis.	Calcium	127-134	cadherin 1	Mus musculus	10-20
25549657-8	2015	EGCG also caused an up-regulation in alpha-smooth muscle actin expression and a down-regulation in E-cadherin expression, indicating the inhibition of epithelial-to-mesenchymal transition.	epigallocatechin gallate	0-4	cadherin 1	Mus musculus	99-109
25230372-3	2015	Our previous study identified miR-506 as a key EMT inhibitor through directly targeting the E-cad transcriptional repressor SNAI2.	mir-506	30-37	cadherin 1	Mus musculus	92-97
25623538-2	2015	In this study, we found that ascophyllan inhibited the migration and adhesion of B16 melanoma cells by reducing the expression of N-cadherin and enhancing the expression of E-cadherin in a concentration-dependent manner.	ascophyllin	29-40	cadherin 1	Mus musculus	173-183
25530018-8	2015	Furthermore, either S-NACH or tinzaparin upregulated the expression of the junctional adhesion molecule E-cadherin in pancreatic cancer cells where its low expression enhances cancer cell migration and invasion.	s-nach	20-26	cadherin 1	Mus musculus	104-114
25530018-8	2015	Furthermore, either S-NACH or tinzaparin upregulated the expression of the junctional adhesion molecule E-cadherin in pancreatic cancer cells where its low expression enhances cancer cell migration and invasion.	Tinzaparin	30-40	cadherin 1	Mus musculus	104-114
25384497-10	2015	Expression of the epithelial markers E-cadherin and beta-catenin decreased in parallel with the reduction in Gg4.	GG4	109-112	cadherin 1	Mus musculus	37-47
26045985-6	2015	Hispidulin was also effective in increasing expression of E-cadherin mRNA in HT29 colorectal cancer xenografts implanted in the nude mice.	hispidulin	0-10	cadherin 1	Mus musculus	58-68
25230372-8	2015	Introduction of miR-506, mediated by nanoparticle delivery, in EOC orthotopic mouse models resulted in decreased vimentin, N-cad, and SNAI2 expression and increased E-cad expression; it also suppressed the dissemination of EOC cells.	mir-506	16-23	cadherin 1	Mus musculus	165-170
25230372-9	2015	Thus, miR-506 represents a new class of miRNA that regulates both E-cad and vimentin/N-cad in the suppression of EMT and metastasis.	mir-506	6-13	cadherin 1	Mus musculus	66-71
25492890-6	2015	E-cadherin expression could be restored after treatment with the DNA de-methylating agent 5-aza-2"-deoxycytidine.	Decitabine	90-112	cadherin 1	Mus musculus	0-10
28962353-0	2015	Mast cells infiltration and decreased E-cadherin expression in ketamine-induced cystitis.	Ketamine	63-71	cadherin 1	Mus musculus	38-48
25587665-3	2015	In the current study, using mice that were intraperitoneally injected with 50 mg/kg cyclophosphamide for 2 days, we reveal that polysaccharides from the ink of Ommastrephes bartrami (OBP) enhanced the mRNA and protein expression levels of Occludin, zonulae occluden (ZO)-1, and E-cadherin.	Cyclophosphamide	84-100	cadherin 1	Mus musculus	278-288
25348955-4	2014	Downregulation of E-cadherin by Six2 was necessary for its ability to increase soft agar growth and in vivo metastasis in an immunocompetent mouse model of breast cancer.	Agar	84-88	cadherin 1	Mus musculus	18-28
25486274-5	2014	In addition, silencing of P2X7 remarkably attenuated ATP- or BzATP- driven expression changes of EMT/invasion-related genes Snail, E-cadherin, Claudin-1, IL-8 and MMP-3, and weakened the phosphorylation of PI3K/AKT and ERK1/2 in vitro.	Adenosine Triphosphate	53-56	cadherin 1	Mus musculus	131-141
25486274-5	2014	In addition, silencing of P2X7 remarkably attenuated ATP- or BzATP- driven expression changes of EMT/invasion-related genes Snail, E-cadherin, Claudin-1, IL-8 and MMP-3, and weakened the phosphorylation of PI3K/AKT and ERK1/2 in vitro.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate	61-66	cadherin 1	Mus musculus	131-141
28962353-9	2015	Additionally, the expression of E-cadherin in ketamine-treated mice bladder tissue was significantly lower than that in the control tissues, P &lt; 0.001.	Ketamine	46-54	cadherin 1	Mus musculus	32-42
25373475-1	2014	E-cadherin belongs to the classic cadherin subfamily of calcium-dependent cell adhesion molecules and is crucial for the formation and function of epithelial adherens junctions.	Calcium	56-63	cadherin 1	Mus musculus	0-10
25277383-8	2014	Western blot analysis, semiquantitative RT-PCR, qRT-PCR, and immunofluorescence demonstrated that doxycycline inhibited the degradation of the epithelial marker E-cadherin and downregulated the expression levels of EMT promoters, the mesenchymal marker vimentin, and the VM-associated marker vascular endothelial (VE)-cadherin.	Doxycycline	98-109	cadherin 1	Mus musculus	161-171
25584145-9	2014	Indeed, we found that 7-day exposure of BNL cells to 3-MC reduced the level of the adhesion molecule and epithelial marker Ecadherin and increased reciprocally the level of the mesenchymal marker vimentin in a dose-dependent manner.	Methylcholanthrene	53-57	cadherin 1	Mus musculus	123-132
25297811-5	2014	Gene ontology analysis also revealed that BaP-induced bioactivities were tissue specific; eight genes (Tubb5, Fos, Cdh1, Cyp1a1, Apc, Myc, Ctnnb1 and Cav) showed significant expression difference between three target and three non-target organs.	Benzo(a)pyrene	42-45	cadherin 1	Mus musculus	115-119
25050737-9	2014	Rottlerin also inhibited epithelial-mesenchymal transition by up-regulating E-cadherin and inhibiting the expression of Slug and Snail.	rottlerin	0-9	cadherin 1	Mus musculus	76-86
24033428-7	2014	SAHA inhibited migration, invasion, and ECM adhesion in ESCC cells with an induction of E-cadherin expression.	Vorinostat	0-4	cadherin 1	Mus musculus	88-98
25226618-5	2014	Biseugenol-exposure tumors showed acquired epithelial features such as phosphorylation of E-cadherin, cytokeratin-18 and loss mesenchymal signature Snail, but not vimentin regulation.	biseugenol	0-10	cadherin 1	Mus musculus	90-100
24978608-6	2014	Sesamin blocked upregulation of the mesenchymal markers (fibronectin and vimentin) and downregulation of the epithelial marker (E-cadherin), indicating an inhibitory effect on TGF-beta1-induced EMT in A549 cells.	sesamin	0-7	cadherin 1	Mus musculus	128-138
24033428-8	2014	SAHA significantly inhibited growth of ESCC tumors with increased expression of p21, p27, Rb, and E-cadherin while decreasing expression of CDK4 and cyclin D1 within the murine tumors.	Vorinostat	0-4	cadherin 1	Mus musculus	98-108
24877640-5	2014	When the administrated dose of SOPH was 600 mg/kg per day, great changes were observed in the exposed uterine morphology and up-regulated progesterone receptor (PR) and down-regulated estrogen receptor alpha (ERalpha), E-cadherin, matrix metalloproteinase-2 (MMP-2) and integrin beta3 were also found in SOPH-exposed uterine.	sophoricoside	31-35	cadherin 1	Mus musculus	219-229
24969048-5	2014	DEN treatment induced Nope expression in ESCs, HPCs and HCs and caused a concomitant increase in E-cadherin expression.	Diethylnitrosamine	0-3	cadherin 1	Mus musculus	97-107
23719484-5	2014	E-cadherin expression was evaluated by immunohistochemistry of formalin-fixed paraffin-embedded skin biopsies of foreign body granulomas (n = 21) and sarcoidosis (n = 21).	Formaldehyde	63-71	cadherin 1	Mus musculus	0-10
23719484-5	2014	E-cadherin expression was evaluated by immunohistochemistry of formalin-fixed paraffin-embedded skin biopsies of foreign body granulomas (n = 21) and sarcoidosis (n = 21).	Paraffin	78-86	cadherin 1	Mus musculus	0-10
24820114-11	2014	Likewise, p,p"-DDT stimulated the JAK/STAT3 pathway in nude mice, as well as altered the mRNA levels of E-cadherin, N-cadherin, and CD29.	DDT	10-18	cadherin 1	Mus musculus	104-114
24840851-4	2014	By use of a mouse model with liver-specific deletion of E-cadherin and administration of the carcinogen diethylnitrosamine, we demonstrate that loss of E-cadherin expression in hepatocytes results in acceleration of the growth of hepatocellular carcinoma (HCC).	Diethylnitrosamine	104-122	cadherin 1	Mus musculus	152-162
24704591-9	2014	In xenografted tumours, E-cadherin displayed a cytoplasmic pattern whereas the treatment of mice with gefitinib restored the membranous expression of E-cadherin.	Gefitinib	102-111	cadherin 1	Mus musculus	150-160
24945595-3	2014	After 72 h of TSA treatment, MUCs acquired epithelial-like features, which were indicated by increased expression of epithelial markers such as Cdh1, Krt18, and Dsp.	trichostatin A	14-17	cadherin 1	Mus musculus	144-148
24889918-11	2014	Administration of mice with LY294002 resulted in upregulation of membrane E-cadherin, and downregulation of vimentin and alpha-SMA in CNE2Z xenografts, with reduced pulmonary metastasis.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	28-36	cadherin 1	Mus musculus	74-84
25036034-6	2014	Additionally, carnosic acid suppressed the mesenchymal markers snail, slug, vimentin, and N-cadherin and induced epithelial marker E-cadherin.	salvin	14-27	cadherin 1	Mus musculus	131-141
24967969-8	2014	Indeed, silencing of ZnR/GPR39 or chelation of Zn(2+) by the cell impermeable chelator CaEDTA was followed by impaired expression of the junctional proteins, that is, occludin, zonula-1 (ZO-1) and E-cadherin.	Zinc	21-23	cadherin 1	Mus musculus	197-207
24967969-8	2014	Indeed, silencing of ZnR/GPR39 or chelation of Zn(2+) by the cell impermeable chelator CaEDTA was followed by impaired expression of the junctional proteins, that is, occludin, zonula-1 (ZO-1) and E-cadherin.	Edetic Acid	87-93	cadherin 1	Mus musculus	197-207
25024609-10	2014	Also, clobenpropit inhibited tumor growth (gemcitabine 294 +- 46 mg vs combination 154 +- 54 mg, P = 0.02) and enhanced apoptosis in combination with gemcitabine (control 2.5%, gemcitabine 25.8%, clobenpropit 9.7% and combination 40.9%, P = 0.001) by up-regulation of E-cadherin and down-regulation of Zeb1 in Panc-1 xenograft mouse.	clobenpropit	6-18	cadherin 1	Mus musculus	268-278
24919421-0	2014	Synthesis of migrastatin and its macroketone analogue and in vivo FRAP analysis of the macroketone on E-cadherin dynamics.	migrastatin	13-24	cadherin 1	Mus musculus	102-112
24378645-6	2014	Nontoxic kaempferol significantly inhibited TGF-beta-induced EMT process through reversing E-cadherin expression and retarding the induction of N-cadherin and alpha-SMA.	kaempferol	9-19	cadherin 1	Mus musculus	91-101
24726524-10	2014	NAC attenuated BLM induced oxidative damage, changes in E-cadherin and vimentin expressions and collagen deposition in the sclerotic skin of mice.	Acetylcysteine	0-3	cadherin 1	Mus musculus	56-66
22859263-0	2014	Ptaquiloside-induced early-stage urothelial lesions show increased cell proliferation and intact beta-catenin and E-cadherin expression.	ptaquiloside	0-12	cadherin 1	Mus musculus	114-124
24940423-7	2014	Intratracheal administration of LY294002 and Akt inhibitor IV to the asthmatic mice was capable of reducing airway inflammation, downregulating the expression of alpha-SMA, type I collagen and fibronectin-1 and increasing the expression of E-cadherin.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	32-40	cadherin 1	Mus musculus	240-250
24374173-9	2014	The expression of protein and mRNA of MMP9 and E-cadherin following treatment with PGE2 were suppressed and increased by celecoxib, respectively; however, MMP2 showed no change.	Dinoprostone	83-87	cadherin 1	Mus musculus	47-57
24374173-9	2014	The expression of protein and mRNA of MMP9 and E-cadherin following treatment with PGE2 were suppressed and increased by celecoxib, respectively; however, MMP2 showed no change.	Celecoxib	121-130	cadherin 1	Mus musculus	47-57
24374173-10	2014	A549 cell invasion and up-regulation of the expression of MMP9 and down-regulation of E-cadherin induced by PGE2 were inhibited by FH535, an inhibitor of beta-catenin.	Dinoprostone	108-112	cadherin 1	Mus musculus	86-96
24374173-10	2014	A549 cell invasion and up-regulation of the expression of MMP9 and down-regulation of E-cadherin induced by PGE2 were inhibited by FH535, an inhibitor of beta-catenin.	FH535	131-136	cadherin 1	Mus musculus	86-96
24374173-11	2014	Deletion of beta-catenin by siRNA abrogated celecoxib-induced inhibition of MMP9 up-regulation and E-cadherin down-regulation by treatment of PGE2.	Celecoxib	44-53	cadherin 1	Mus musculus	99-109
24374173-11	2014	Deletion of beta-catenin by siRNA abrogated celecoxib-induced inhibition of MMP9 up-regulation and E-cadherin down-regulation by treatment of PGE2.	Dinoprostone	142-146	cadherin 1	Mus musculus	99-109
24586868-6	2014	However, only calcitriol increased expression of the pro-differentiation marker, cadherin 1 (p = 0.0086), and reduced tumor proliferation (p = 0.0467).	Calcitriol	14-24	cadherin 1	Mus musculus	81-91
24295266-0	2013	Inhibitor of 5-lipoxygenase, zileuton, suppresses prostate cancer metastasis by upregulating E-cadherin and paxillin.	zileuton	29-37	cadherin 1	Mus musculus	93-103
24599758-6	2014	Our results demonstrated that CCI caused a rapid decrease in E-cadherin and membrane-associated p120ctn in the spinal dorsal horn.	CCI	30-33	cadherin 1	Mus musculus	61-71
24599758-7	2014	Together, these data demonstrated that E-cadherin-associated p120ctn was upregulated by GDNF and that this upregulation was inhibited by pre-treatment with DECMA-1.	decma-1	156-163	cadherin 1	Mus musculus	39-49
24184502-0	2014	Modulation of N-glycosylation by mesalamine facilitates membranous E-cadherin expression in colon epithelial cells.	Mesalamine	33-43	cadherin 1	Mus musculus	67-77
24184502-4	2014	We have recently demonstrated that mesalamine (5-ASA); the anti-inflammatory drug used to treat ulcerative colitis, induces membranous expression of E-cadherin and increases intercellular adhesion.	Mesalamine	35-45	cadherin 1	Mus musculus	149-159
24184502-4	2014	We have recently demonstrated that mesalamine (5-ASA); the anti-inflammatory drug used to treat ulcerative colitis, induces membranous expression of E-cadherin and increases intercellular adhesion.	Mesalamine	47-52	cadherin 1	Mus musculus	149-159
24184502-6	2014	Post-translational modification of E-cadherin glycosylation was analyzed by biotin/streptavidin detection of sialylated glycoproteins.	Biotin	76-82	cadherin 1	Mus musculus	35-45
24184502-10	2014	5-ASA activity modulated E-cadherin glycosylation and increased both mRNA and protein levels of GnT-III and its activity as detected by increased E4-lectin reactivity.	Mesalamine	0-5	cadherin 1	Mus musculus	25-35
24184502-12	2014	The data demonstrated that remodeling of glycans by GnT-III mediated bisect glycosylation, contributes to the membranous retention of E-cadherin by 5-ASA; facilitating intercellular adhesion.	Polysaccharides	41-48	cadherin 1	Mus musculus	134-144
24184502-12	2014	The data demonstrated that remodeling of glycans by GnT-III mediated bisect glycosylation, contributes to the membranous retention of E-cadherin by 5-ASA; facilitating intercellular adhesion.	Mesalamine	148-153	cadherin 1	Mus musculus	134-144
24184502-13	2014	Induction of membranous expression of E-cadherin by 5-ASA is a novel mechanism for mucosal healing in colitis that might impede tumor progression by modulation of GnT-III expression.	Mesalamine	52-57	cadherin 1	Mus musculus	38-48
24424429-5	2014	In addition, CS-A and CS-E polysaccharides, but not CS-C polysaccharides, bound to E-cadherin and enhanced ESC differentiation.	cs-e polysaccharides	22-42	cadherin 1	Mus musculus	83-93
24424429-7	2014	Collectively, these results suggest that CS is a novel determinant in controlling the functional integrity of ESCs via binding to E-cadherin.	Chondroitin Sulfates	41-43	cadherin 1	Mus musculus	130-140
25147816-9	2014	Translocation of E-cadherin was also seen in tumors from a transgenic mouse model of pancreatic cancer and in a human non-small cell lung cancer sample from a patient treated with PEGPH20.	pegph20	180-187	cadherin 1	Mus musculus	17-27
23962793-5	2014	E-cadherin levels were suppressed by male exposure, particularly during GD 4-6 Serum progesterone levels were also reduced in male-exposed females.	Progesterone	85-97	cadherin 1	Mus musculus	0-10
24297939-4	2013	Here, we identify the essential cell-cell adhesion glycoprotein epithelial (E)-cadherin as an O-mannosylated protein and establish a functional link between O-mannosyl glycans and cadherin-mediated cell-cell adhesion.	o-mannosyl glycans	157-175	cadherin 1	Mus musculus	79-87
24297939-7	2013	Using mass spectrometry, we demonstrate that O-mannosyl glycans are present on E-cadherin, the major cell-adhesion molecule of blastomeres, and present evidence that this modification is generally conserved in cadherins.	o-mannosyl glycans	45-63	cadherin 1	Mus musculus	79-89
24688730-3	2013	Using molecular dynamics simulations, MM/GBSA free energy calculations, hydrogen bond analysis, water characterization and umbrella sampling, we provide a complete atomistic picture of the binding between inlA and Ecad.	Hydrogen	72-80	cadherin 1	Mus musculus	214-218
24688730-3	2013	Using molecular dynamics simulations, MM/GBSA free energy calculations, hydrogen bond analysis, water characterization and umbrella sampling, we provide a complete atomistic picture of the binding between inlA and Ecad.	Water	96-101	cadherin 1	Mus musculus	214-218
24169697-4	2013	Here, we propose a novel mechanism whereby the loss of PTEN negatively affects the activity of the E3 ligase APC/C-Cdh1, resulting in the stabilization of the enzyme PFKFB3 and increased synthesis of its product fructose 2,6-bisphosphate (F2,6P2).	fructose 2,6-diphosphate	212-237	cadherin 1	Mus musculus	115-119
24295266-15	2013	CONCLUSION: The inhibitor of 5-LOX, zileuton, can suppress prostate cancer metastasis by repaired expression of E-cadherin and paxillin.	zileuton	36-44	cadherin 1	Mus musculus	112-122
23688655-6	2013	gammaH2AX immunostaining of the bleomycin-treated lungs revealed double-strand breaks (DSBs), largely within E-cadherin-positive, beta4-integirn-positive alveolar epithelial cells.	Bleomycin	32-41	cadherin 1	Mus musculus	109-119
24517069-8	2013	Compared with the model group, E-cadherin (+) percentage rate significantly increased (P &lt; 0.05) and albumin permeability across podocyte monolayers decreased significantly (P &lt; 0.05) in the high and low dose resveratrol groups.	Resveratrol	215-226	cadherin 1	Mus musculus	31-41
24517069-11	2013	The correlations between resveratrol concentrations and the expression of E-cadherin (+), P-cadherin, and NEPH1 were significantly positive (r(E-cadherin (+)) = 0.772, r(P-cadherin) = 0.756, r(NEPH1) = 0.809, P &lt; 0.05).	Resveratrol	25-36	cadherin 1	Mus musculus	74-84
24517069-11	2013	The correlations between resveratrol concentrations and the expression of E-cadherin (+), P-cadherin, and NEPH1 were significantly positive (r(E-cadherin (+)) = 0.772, r(P-cadherin) = 0.756, r(NEPH1) = 0.809, P &lt; 0.05).	Resveratrol	25-36	cadherin 1	Mus musculus	143-153
23828905-4	2013	Honokiol-treated tumors showed increased epithelial signatures such as E-cadherin, cytokeratin-18 and ER stress marker.	honokiol	0-8	cadherin 1	Mus musculus	71-81
23828905-6	2013	TGFbeta1 and MNNG-induced downregulation of E-cadherin and upregulation of Tpl2 were abrogated by Honokiol treatment.	honokiol	98-106	cadherin 1	Mus musculus	44-54
23684930-9	2013	EA also reversed epithelial to mesenchymal transition by up-regulating E-cadherin and inhibiting the expression of Snail, MMP-2 and MMP-9.	Ellagic Acid	0-2	cadherin 1	Mus musculus	71-81
23045282-7	2013	Activation of Elk-1 facilitates recruitment of phosphorylated MSK1, which in turn enhances histone H3 acetylation and phosphorylation (serine 10) of Snail promoter, resulting in Snail enhancement and E-cadherin downregulation.	Serine	135-141	cadherin 1	Mus musculus	200-210
23744610-5	2013	In cholangiocytes isolated and cultured from Pkhd1(del4/del4) mice, stimulation of cAMP/PKA signaling (forskolin 10 muM) stimulated Ser(675) -phosphorylation of beta-catenin, its nuclear localization, and its transcriptional activity (western blot and TOP flash assay, respectively) along with a down-regulation of E-cadherin expression (immunocytochemistry and western blot); these changes were inhibited by the PKA blocker, PKI (1 muM).	Cyclic AMP	83-87	cadherin 1	Mus musculus	315-325
23744610-5	2013	In cholangiocytes isolated and cultured from Pkhd1(del4/del4) mice, stimulation of cAMP/PKA signaling (forskolin 10 muM) stimulated Ser(675) -phosphorylation of beta-catenin, its nuclear localization, and its transcriptional activity (western blot and TOP flash assay, respectively) along with a down-regulation of E-cadherin expression (immunocytochemistry and western blot); these changes were inhibited by the PKA blocker, PKI (1 muM).	Colforsin	103-112	cadherin 1	Mus musculus	315-325
23948355-6	2013	In the presence of PFOA or PFOS, expression levels of E-cadherin and connexin-43 mRNAs were significantly downregulated, and spheroids were dissociated into single cell populations, indicating that the compounds affect the synthesis of E-cadherin and connexin-43 at the transcriptional level.	perfluorooctanoic acid	19-23	cadherin 1	Mus musculus	54-64
23948355-6	2013	In the presence of PFOA or PFOS, expression levels of E-cadherin and connexin-43 mRNAs were significantly downregulated, and spheroids were dissociated into single cell populations, indicating that the compounds affect the synthesis of E-cadherin and connexin-43 at the transcriptional level.	perfluorooctanoic acid	19-23	cadherin 1	Mus musculus	236-246
23948355-6	2013	In the presence of PFOA or PFOS, expression levels of E-cadherin and connexin-43 mRNAs were significantly downregulated, and spheroids were dissociated into single cell populations, indicating that the compounds affect the synthesis of E-cadherin and connexin-43 at the transcriptional level.	perfluorooctane sulfonic acid	27-31	cadherin 1	Mus musculus	54-64
23948355-6	2013	In the presence of PFOA or PFOS, expression levels of E-cadherin and connexin-43 mRNAs were significantly downregulated, and spheroids were dissociated into single cell populations, indicating that the compounds affect the synthesis of E-cadherin and connexin-43 at the transcriptional level.	perfluorooctane sulfonic acid	27-31	cadherin 1	Mus musculus	236-246
23644405-9	2013	Incubation of these cells with the GSK inhibitor CHIR99021 and the E-cadherin stabilizer Thiazovivin resulted in colony formation by 25% to 30% of single-sorted ISCs.	thiazovivin	89-100	cadherin 1	Mus musculus	67-77
23977447-4	2013	The treatment of low E-cadherin lung cancer cell lines with histone deacetylase inhibitor (HDACi, MS-275) resulted in the preferential expression of the correctly spliced transcripts in the low E-cadherin expressing cell lines only.	entinostat	98-104	cadherin 1	Mus musculus	21-31
23977447-4	2013	The treatment of low E-cadherin lung cancer cell lines with histone deacetylase inhibitor (HDACi, MS-275) resulted in the preferential expression of the correctly spliced transcripts in the low E-cadherin expressing cell lines only.	entinostat	98-104	cadherin 1	Mus musculus	194-204
23566898-6	2013	Pretreatment with dexamethasone (DEX) significantly rescued the immunoreactivity of E-cadherin, accompanied by increased neutrophils in bronchoalveolar lavage fluid (BALF).	Dexamethasone	18-31	cadherin 1	Mus musculus	84-94
23566898-6	2013	Pretreatment with dexamethasone (DEX) significantly rescued the immunoreactivity of E-cadherin, accompanied by increased neutrophils in bronchoalveolar lavage fluid (BALF).	Dexamethasone	33-36	cadherin 1	Mus musculus	84-94
23566898-0	2013	Mechanism of E-cadherin redistribution in bronchial airway epithelial cells in a TDI-induced asthma model.	Toluene 2,4-Diisocyanate	81-84	cadherin 1	Mus musculus	13-23
23566898-9	2013	These results indicate that E-cadherin redistribution may be an important contributor in the generation of TDI-induced asthma.	Toluene 2,4-Diisocyanate	107-110	cadherin 1	Mus musculus	28-38
23566898-4	2013	Here, we hypothesize that TDI can injure E-cadherin both in normal and allergic-induced airway epithelium.	Toluene 2,4-Diisocyanate	26-29	cadherin 1	Mus musculus	41-51
23566898-5	2013	To test this, we developed a murine model of TDI-induced asthma characterized by neutrophil-dominated airway inflammation, epithelial shedding, and obvious aberrant distribution of E-cadherin.	Toluene 2,4-Diisocyanate	45-48	cadherin 1	Mus musculus	181-191
23777889-12	2013	Furthermore, seven days after the injury, MRPC/EPO or MRPC/suramin formed more CD34(+) and E-cadherin+ cells than MRPC alone.	Suramin	59-66	cadherin 1	Mus musculus	91-101
23487312-2	2013	One of the hallmarks of mES cells, their compact growth morphology, results from tight cell adhesion mediated through E-cadherin, beta-catenin (Ctnnb1) and alpha-catenin with the actin cytoskeleton.	2-(N-morpholino)ethanesulfonic acid	24-27	cadherin 1	Mus musculus	118-128
23645249-4	2013	Herein, we report that post-weaning dietary exposure to soy protein isolate and its bioactive isoflavone genistein (GEN) lowered mammary adiposity and increased mammary tumor suppressor PTEN and E-cadherin expression in female mice, relative to control casein diet.	Isoflavones	94-104	cadherin 1	Mus musculus	195-205
23645249-4	2013	Herein, we report that post-weaning dietary exposure to soy protein isolate and its bioactive isoflavone genistein (GEN) lowered mammary adiposity and increased mammary tumor suppressor PTEN and E-cadherin expression in female mice, relative to control casein diet.	Genistein	105-114	cadherin 1	Mus musculus	195-205
23637793-6	2013	Tamoxifen blocked the MMT induced by transforming growth factor (TGF)-beta1, as it preserved the expression of E-cadherin and reduced the expression of mesenchymal-associated molecules such as snail, fibronectin, collagen-I, alpha-smooth muscle actin, and matrix metalloproteinse-2.	Tamoxifen	0-9	cadherin 1	Mus musculus	111-121
23276794-1	2013	We showed previously that breast cancer chemoprevention with benzyl isothiocyanate (BITC) in MMTV-neu mice was associated with induction of E-cadherin protein in vivo.	benzyl isothiocyanate	61-82	cadherin 1	Mus musculus	140-150
23276794-1	2013	We showed previously that breast cancer chemoprevention with benzyl isothiocyanate (BITC) in MMTV-neu mice was associated with induction of E-cadherin protein in vivo.	benzyl isothiocyanate	84-88	cadherin 1	Mus musculus	140-150
23274568-12	2013	A marked decrease in the expression of mesenchymal markers such as Fibronectin, N-cadherin, SNAI, Slug and Twist and an increase in epithelial cell polarity marker E-cadherin were noted in NO-sulindac-treated tumors.	Sulindac	192-200	cadherin 1	Mus musculus	164-174
23487312-9	2013	In summary, we put forward a model in which mES cells can be propagated in culture in the absence of Ctnnb1, as long as E-cadherin-mediated cell adhesion is preserved.	2-(N-morpholino)ethanesulfonic acid	44-47	cadherin 1	Mus musculus	120-130
23537295-6	2013	In addition, immunohistochemical studies on mouse tumors injected with cisplatin or paclitaxel treated residual cells displayed higher staining for the proliferative antigen Ki67, oncogeneic CA125, epithelial E-cadherin as well as cancer stem cell markers such as Oct4 and CD117, compared to mice injected with control untreated cells.	Cisplatin	71-80	cadherin 1	Mus musculus	209-219
23537295-6	2013	In addition, immunohistochemical studies on mouse tumors injected with cisplatin or paclitaxel treated residual cells displayed higher staining for the proliferative antigen Ki67, oncogeneic CA125, epithelial E-cadherin as well as cancer stem cell markers such as Oct4 and CD117, compared to mice injected with control untreated cells.	Paclitaxel	84-94	cadherin 1	Mus musculus	209-219
23087054-10	2013	Acute exposure of infant mice to DCB-230 resulted in EMT, as confirmed by lineage tracing studies and evidenced by coexpression of epithelial E-cadherin and mesenchymal alpha-SMA proteins in airway cells and increased SNAI1 expression in the lungs.	dcb-230	33-40	cadherin 1	Mus musculus	142-152
23283523-4	2013	HCA induces epithelial reversion at nanomolar concentrations by suppressing Snail via the nuclear translocalization of GSK-3beta, which results in the transcriptional upregulation of E-cadherin.	hca	0-3	cadherin 1	Mus musculus	183-193
23071158-8	2013	Knockdown of MMP8 or incubation with the a-disintegrin-and-metalloproteinase-domain-10 inhibitor GI254023X decreased E-cadherin shedding on SPCs.	3-(formylhydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid (2,2-dimethyl-1-methylcarbamoyl-1-propyl)amide	97-106	cadherin 1	Mus musculus	117-127
23239155-10	2013	The lungs of bleomycin-treated SOPten(Delta/Delta) mice showed increased pAkt, pS6K, Snail, and matrix metalloproteinase expressions and decreased claudin-4, E-cadherin, and laminin-beta1 expressions.	Bleomycin	13-22	cadherin 1	Mus musculus	158-168
23251277-8	2013	Furthermore, alendronate sodium markedly reduced TGF-beta1 and alpha-SMA mRNA expression and increased BMP-7 and E-cadherin in the mouse liver tissue (P&lt;0.001).	Alendronate	13-31	cadherin 1	Mus musculus	113-123
24377529-6	2013	DEN treatment increased GPC- 3 expression in ESCs, HPCs and HCs, with increase of E-cadherin expression.	Diethylnitrosamine	0-3	cadherin 1	Mus musculus	82-92
23682784-1	2013	We have shown previously that cancer prevention by cruciferous vegetable constituent phenethyl isothiocyanate (PEITC) in a transgenic mouse model of prostate cancer is associated with induction of E-cadherin protein expression.	phenethyl isothiocyanate	85-109	cadherin 1	Mus musculus	197-207
23203799-10	2013	Inhibition of beta-catenin by either F-TrCP-Ecad or ICG-001 abolished LiCl-induced TOP-flash, but not TGF-beta1-induced Smad reporter, activity in J774 cells.	Lithium Chloride	70-74	cadherin 1	Mus musculus	44-48
23682784-1	2013	We have shown previously that cancer prevention by cruciferous vegetable constituent phenethyl isothiocyanate (PEITC) in a transgenic mouse model of prostate cancer is associated with induction of E-cadherin protein expression.	phenethyl isothiocyanate	111-116	cadherin 1	Mus musculus	197-207
23405120-5	2013	As other MCs; uterine MCs (UtMCs) uniformly expressed the epithelial markers beta-catenin, ZO-1, E-cadherin, CD54, CD29, and CK18.	mcs	22-25	cadherin 1	Mus musculus	97-107
23548313-0	2013	E-cadherin and beta-catenin expression during urothelial carcinogenesis induced by N-butyl-N-(4-hydroxybutyl) nitrosamine in mice.	Butylhydroxybutylnitrosamine	83-121	cadherin 1	Mus musculus	0-10
22552906-3	2012	The lymphocyte-enhanced epithelial HCO(3)- secretion and bacterial killing activity was abolished when Calu3 cells were co-cultured with lymphocytes from CFTR knockout mice, or significantly reduced by interfering with E-cadherin, a putative binding partner of CFTR.	Bicarbonates	35-41	cadherin 1	Mus musculus	219-229
22815157-9	2012	We have demonstrated that adsorption of 15 mug/mL of the full extracellular domain of E-cadherin to titanium alloy significantly increases metabolic activity, cell area, and attachment of murine keratinocytes in vitro, with a fourfold increase in attachment via adherens junctions at 24, 48, and 72 h.	Titanium	100-114	cadherin 1	Mus musculus	86-96
23291126-9	2012	A decreased expression of E-cadherin and increased expression of N-cadherin, vimentin and transcription factor Snail were detected in the oxaliplatin pre-treated tumors by immunohistochemistry, which provided the evidence of epithelial mesenchymal transition (EMT) in these tumors.	Oxaliplatin	138-149	cadherin 1	Mus musculus	26-36
23328429-7	2012	In E-cad-ESC group, hepatic markers ALB, TAT and CYP7a1 were expressed earlier or higher than that in normal ESC group, and the concentrations of ALB and urea were significantly higher than that in normal ESC group.	Urea	154-158	cadherin 1	Mus musculus	3-8
23328429-11	2012	CONCLUSION: E-cad enhances the hepatic differentiation of ESC by increasing the number of differentiated cells and increasing the synthetic capacity of ALB and urea.	Urea	160-164	cadherin 1	Mus musculus	12-17
22902510-0	2012	Triptolide inhibits ovarian cancer cell invasion by repression of matrix metalloproteinase 7 and 19 and upregulation of E-cadherin.	triptolide	0-10	cadherin 1	Mus musculus	120-130
22902510-6	2012	Moreover, triptolide enhanced E-cadherin expression in ovarian cancer cells.	triptolide	10-20	cadherin 1	Mus musculus	30-40
22902510-7	2012	In vivo, triptolide inhibited tumor formation and metastasis in nude mice, and suppressed MMP7 and MMP19 expression; it also enhanced E-cadherin expression in tumor in a dose-dependent manner.	triptolide	9-19	cadherin 1	Mus musculus	134-144
22902510-8	2012	Over expression of MMP7 and MMP19, or suppression of E-cadherin expression partially abolished the inhibitory effect of triptolide on invasion of ovarian cancer cells.	triptolide	120-130	cadherin 1	Mus musculus	53-63
22902510-9	2012	To summarize, triptolide significantly inhibited the migration and invasion of ovarian cancer cells by suppression of MMP7 and MMP19 and up-regulation of E-cadherin expression.	triptolide	14-24	cadherin 1	Mus musculus	154-164
22706342-9	2012	The methylation status of Cdh1, Pgr and Esr1 promoter regions was determined by methylation-specific PCR and bisulfite sequencing.	hydrogen sulfite	109-118	cadherin 1	Mus musculus	26-30
24716145-3	2012	Both SB and PTX alone or SB+PTX treatment inhibited 4T1 cell migration and motility possibly through downregulation of the serpin protease nexin-1 (PN-1) and N-cadherin expression, inhibition of matrix metalloprotease (MMP)-9 activity, and upregulation of E-cadherin.	Silybin	5-7	cadherin 1	Mus musculus	256-266
24716145-3	2012	Both SB and PTX alone or SB+PTX treatment inhibited 4T1 cell migration and motility possibly through downregulation of the serpin protease nexin-1 (PN-1) and N-cadherin expression, inhibition of matrix metalloprotease (MMP)-9 activity, and upregulation of E-cadherin.	Paclitaxel	12-15	cadherin 1	Mus musculus	256-266
24716145-3	2012	Both SB and PTX alone or SB+PTX treatment inhibited 4T1 cell migration and motility possibly through downregulation of the serpin protease nexin-1 (PN-1) and N-cadherin expression, inhibition of matrix metalloprotease (MMP)-9 activity, and upregulation of E-cadherin.	Silybin	25-27	cadherin 1	Mus musculus	256-266
24716145-3	2012	Both SB and PTX alone or SB+PTX treatment inhibited 4T1 cell migration and motility possibly through downregulation of the serpin protease nexin-1 (PN-1) and N-cadherin expression, inhibition of matrix metalloprotease (MMP)-9 activity, and upregulation of E-cadherin.	Paclitaxel	28-31	cadherin 1	Mus musculus	256-266
22504877-7	2012	iPS cell-derived EBs were induced by retinoic acid to differentiate into spermatogonial stem cells (SSCs), as evidenced by their expression of VASA, as well as CDH1 and GFRalpha1, which are markers of SSCs.	IPS	0-3	cadherin 1	Mus musculus	160-164
22775504-3	2012	This phenomenon is initiated by TGFbeta3 upon adherence of opposing palatal shelves, and subsequently epithelial-mesenchymal transition (EMT) instigates the loss of E-Cadherin, causing the MES to break into small epithelial islands forming confluent palatal mesenchyme; however, apoptosis and cell migration or in combination of all are other established mechanisms of seam disintegration.	2-(N-morpholino)ethanesulfonic acid	189-192	cadherin 1	Mus musculus	165-175
22579465-7	2012	Interestingly, sirolimus preserved renal epithelial cell expression of E-cadherin in TgS.	Sirolimus	15-24	cadherin 1	Mus musculus	71-81
22579465-8	2012	Since sirolimus attenuated renal cell ZEB expression (a repressor of E-cadherin transcription), it appears that sirolimus may be attenuating renal cell EMT by preserving epithelial cell E-cadherin expression.	Sirolimus	6-15	cadherin 1	Mus musculus	69-79
22579465-8	2012	Since sirolimus attenuated renal cell ZEB expression (a repressor of E-cadherin transcription), it appears that sirolimus may be attenuating renal cell EMT by preserving epithelial cell E-cadherin expression.	Sirolimus	112-121	cadherin 1	Mus musculus	186-196
22960887-10	2012	In vitro culture revealed that Lin - BMCs differentiated into megalin, E-cadherin and cytokeratin-19 (CK-19) expressing renal epithelial cells.	lin - bmcs	31-41	cadherin 1	Mus musculus	71-81
22692956-5	2012	Additionally, the repressive effect of resveratrol on in vitro malignant properties including invasiveness/anchorage-independent growth was mediated by regulating productions of EMT markers Slug, ZEB1, N-cadherin, E-cadherin, and Vimentin.	Resveratrol	39-50	cadherin 1	Mus musculus	214-224
22813799-6	2012	METHODS: Paraffin sections were generated for H&amp;E, E-cadherin, or terminal deoxynucleotidyl transferase-mediated X-dUTP nick end labeling staining from Fgfr2IIIb-/- and wild-type embryos between embryonic days (E) 10.5 and E14.5.	Paraffin	9-17	cadherin 1	Mus musculus	55-65
22520296-4	2012	We report that the completely homogeneous population of mES and miPS cells could be maintained on E-cadherin-based substrata under feeder- and serum-free culture conditions to initiate neural differentiation.	2-(N-morpholino)ethanesulfonic acid	56-59	cadherin 1	Mus musculus	98-108
22419696-6	2012	In cultured mouse proximal tubular epithelial cells (mProx24), ONO-1301 significantly ameliorated the expression of fibroblast-specific protein-1 and alpha-smooth muscle actin as well as phosphorylation of Smad3 and increased the expression of zonula occludens-1 and E-cadherin in the presence of TGF-beta1 as detected by immunoblot and immunocytochemistry, partly dependent on PGI(2) receptor-mediated signaling.	ONO 1301	63-71	cadherin 1	Mus musculus	267-277
22500093-5	2012	Troglitazone resulted in an elongated morphology, 60% decreases in E-cadherin and beta-catenin, a 35% decrease in alpha-catenin, and a 1.5-fold increase in fibronectin.	Troglitazone	0-12	cadherin 1	Mus musculus	67-77
22406420-7	2012	RESULTS: First exposure to exogenous estradiol resulted in OSE hypertrophy and hyperplasia, and high levels of E-cadherin expression.	Estradiol	37-46	cadherin 1	Mus musculus	111-121
22210715-8	2012	Additionally, ethanol reduced Snai1 expression and increased E-cadherin expression.	Ethanol	14-21	cadherin 1	Mus musculus	61-71
21744871-6	2011	Consumption of lycopene could also augment the E-cadherin adherent molecule and nuclear levels of cell cycle inhibitor p21(CIP1/WAF1) protein.	Lycopene	15-23	cadherin 1	Mus musculus	47-57
21803027-7	2011	In this regard, VCN-2 in combination with DTL synergistically inhibited the growth of prostate tumors in vivo with a greater decrease in the levels of AR, pIGF1R, pAkt, PCNA, cyclin D1, Ki67, CD31, and increase in E-cadherin.	Docetaxel	42-45	cadherin 1	Mus musculus	214-224
21596473-8	2011	When the ATII-like cells were exposed to either bleomycin or a TGF(b1)-EGF cocktail, they underwent phenotypic changes including acquisition of a mesenchymal/fibroblastic morphology, upregulation of mesenchymal markers (Col1, Vim, a-Sma, and S100A4), and downregulation of surfactant proteins and E-cadherin.	Bleomycin	48-57	cadherin 1	Mus musculus	297-307
21169555-4	2011	Overexpression of the surfactant protein (SP)-C BRICHOS mutant SP-C(DeltaExon4) in A549 cells increased Grp78 and alpha-SMA and disrupted ZO-1 distribution, and, in primary AECs, SP-C(DeltaExon4) induced fibroblastic-like morphology, decreased ZO-1 and E-cadherin and increased alpha-SMA, mechanistically linking ER stress associated with mutant SP to fibrosis through EMT.	sp	42-44	cadherin 1	Mus musculus	253-263
21557297-4	2011	Interestingly, activation of EGFR by EGF induced production of matrix metalloproteinase-9 (MMP-9) and soluble E-cadherin (sE-cad), and knockdown of MMP-9 by siRNA inhibited sE-cad production induced by EGF in SCC10A.	se-cad	122-128	cadherin 1	Mus musculus	110-120
21782891-6	2011	Immunocytochemical stainings for the vesicular GABA (VGAT) and glutamate (VGLUT1) transporters revealed a reduced density of dendritic GABAergic synapses in E-cadherin knockout neurons, whereas glutamatergic synapses were unaffected.	gamma-Aminobutyric Acid	47-51	cadherin 1	Mus musculus	157-167
21782891-6	2011	Immunocytochemical stainings for the vesicular GABA (VGAT) and glutamate (VGLUT1) transporters revealed a reduced density of dendritic GABAergic synapses in E-cadherin knockout neurons, whereas glutamatergic synapses were unaffected.	Glutamic Acid	63-72	cadherin 1	Mus musculus	157-167
21464039-7	2011	Inhibition of MDA-MB-231 xenograft growth in vivo in female athymic mice by BITC administration was associated with an increase in protein level of E-cadherin and suppression of vimentin and fibronectin protein expression.	benzyl isothiocyanate	76-80	cadherin 1	Mus musculus	148-158
21804545-5	2011	This process results in asymmetric localization of E-cadherin and, as a consequence, in differences in cell affinity between EphB-positive and ephrin-B-positive cells.	ephb	125-129	cadherin 1	Mus musculus	51-61
21804545-5	2011	This process results in asymmetric localization of E-cadherin and, as a consequence, in differences in cell affinity between EphB-positive and ephrin-B-positive cells.	ephrin-b	143-151	cadherin 1	Mus musculus	51-61
21143191-9	2011	In conclusion, we show for the first time that the myocardial protection afforded by rIPC is mediated via the PI3K/Akt/GSK3beta signalling pathway, activation of which is associated with nuclear accumulation of beta-catenin and the up-regulation of its downstream targets E-cadherin and PPARdelta involved in cell survival.	ripc	85-89	cadherin 1	Mus musculus	272-282
21514443-9	2011	Addition of GM6001 (MMP inhibitor) or NSC23766 (Rac1 inhibitor) indicated two distinct induction pathways, one for E-cadherin/beta-catenin and one for MCP-1, TNF-alpha, and MMP-9.	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	12-18	cadherin 1	Mus musculus	115-125
21354196-11	2011	Proteomic analysis of urine identified a number of differentially regulated proteins that may be involved in early CsA nephropathy including cadherin 1, superoxide dismutase and vinculin.	Cyclosporine	115-118	cadherin 1	Mus musculus	141-151
21163520-5	2011	The co-expression of E-cahderin and alpha-fetoprotein (approximately 98%) suggests the important role of E-cadherin as a surface marker for the enrichment of hepatic progenitor cells.	e-cahderin	21-31	cadherin 1	Mus musculus	105-115
21304051-11	2011	2HF also increased the expression of E-cadherin in VHL-mutant RCC, which would be of significance in restoring normal epithelial phenotype.	2'-hydroxyflavanone	0-3	cadherin 1	Mus musculus	37-47
21679035-3	2011	The aim of this study was to elucidate the effects of NS-398 in the 1,2-dimethylhydrazine (DMH) mouse model with respect to alteration in the expression of COX-2 and E-cadherin-catenin complex.	N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide	54-60	cadherin 1	Mus musculus	166-176
21146521-7	2011	Furthermore, Ser 1601-unphosphorylated Scribble was selectively coprecipitated with E-cadherin-catenin complexes in E-cadherin-expressing mouse L fibroblasts.	Serine	13-16	cadherin 1	Mus musculus	84-94
21146521-7	2011	Furthermore, Ser 1601-unphosphorylated Scribble was selectively coprecipitated with E-cadherin-catenin complexes in E-cadherin-expressing mouse L fibroblasts.	Serine	13-16	cadherin 1	Mus musculus	116-126
21679035-3	2011	The aim of this study was to elucidate the effects of NS-398 in the 1,2-dimethylhydrazine (DMH) mouse model with respect to alteration in the expression of COX-2 and E-cadherin-catenin complex.	1,2-Dimethylhydrazine	68-89	cadherin 1	Mus musculus	166-176
21679035-3	2011	The aim of this study was to elucidate the effects of NS-398 in the 1,2-dimethylhydrazine (DMH) mouse model with respect to alteration in the expression of COX-2 and E-cadherin-catenin complex.	1,2-Dimethylhydrazine	91-94	cadherin 1	Mus musculus	166-176
21321321-11	2011	Expressions of cell adhesion gene S100a9 and E-cadherin were altered by HgCl(2), arsenite and realgar.	arsenite	81-89	cadherin 1	Mus musculus	45-55
21779327-6	2011	We further show that Ecad-/- ES cells maintain a functional beta-catenin pool that is able to induce beta-catenin/TCF-mediated transactivation but, contrary to previous findings, do not display endogenous beta-catenin/TCF-mediated transactivation.	tcf	114-117	cadherin 1	Mus musculus	21-25
21776459-10	2010	Changes in aberrantly expressed proteins in the sphingomyelin-fed group, such as E-cadherin, VEGF and sphingosine kinase-1, may be associated with the suppression of tumor growth.	Sphingomyelins	48-61	cadherin 1	Mus musculus	81-91
21159608-4	2010	Activation of PPAR-gamma by synthetic ligands (troglitazone and rosiglitazone) or by a constitutively active form of PPAR-gamma prevents TGF-beta-induced loss of E-cadherin expression and inhibits the induction of mesenchymal markers (vimentin, N-cadherin, fibronectin) and matrix metalloproteases.	Troglitazone	47-59	cadherin 1	Mus musculus	162-172
21159608-4	2010	Activation of PPAR-gamma by synthetic ligands (troglitazone and rosiglitazone) or by a constitutively active form of PPAR-gamma prevents TGF-beta-induced loss of E-cadherin expression and inhibits the induction of mesenchymal markers (vimentin, N-cadherin, fibronectin) and matrix metalloproteases.	Rosiglitazone	64-77	cadherin 1	Mus musculus	162-172
21042743-0	2010	R-etodolac induces E-cadherin and suppresses colitis-related mouse colon tumorigenesis.	Etodolac	0-10	cadherin 1	Mus musculus	19-29
21042743-13	2010	Although R-etodolac treatment did not affect COX-2 expression, it significantly enhanced expression of E-cadherin in both neoplastic lesions and background mucosa (i.e., lesion-free colon).	Etodolac	9-19	cadherin 1	Mus musculus	103-113
21041383-8	2010	Interestingly, MS-275 caused "cadherin switch" and reversed EMT as shown by the upregulation of E-cadherin and downregulation of N-cadherin and transcription factors Snail, Slug, and ZEB1.	entinostat	15-21	cadherin 1	Mus musculus	30-38
21041383-8	2010	Interestingly, MS-275 caused "cadherin switch" and reversed EMT as shown by the upregulation of E-cadherin and downregulation of N-cadherin and transcription factors Snail, Slug, and ZEB1.	entinostat	15-21	cadherin 1	Mus musculus	96-106
20564330-6	2010	The histone deacetylase inhibitor trichostatin A (TSA) inhibited EMT; this was reflected by the preservation of epithelial markers and function (E-cadherin and albumin).	trichostatin A	34-48	cadherin 1	Mus musculus	145-155
20713448-7	2010	In the calcium switch assay, E-cadherin lost the ability to associate with beta-catenin and accumulated in cytoplasm in TM knockdown cells.	Calcium	7-14	cadherin 1	Mus musculus	29-39
20713448-10	2010	Besides, forced expression of murine TM in TM knockdown cells made the cells reassume epithelium-like morphology and increased calcium-dependent association of E-cadherin and beta-catenin.	Calcium	127-134	cadherin 1	Mus musculus	160-170
20652949-8	2010	Placentas without Cdh1 expression are impaired and incapable of establishing a proper connection between the embryonic and the maternal blood vessels for efficient nutrient and oxygen transport.	Oxygen	177-183	cadherin 1	Mus musculus	18-22
20467348-10	2010	With the use of MIN6 monolayers as a control, the expression of the adhesion molecule E-cadherin and connexin 36 were found to be enhanced in cells cultured as pseudoislets.	min6	16-20	cadherin 1	Mus musculus	86-96
20716632-8	2010	Sulindac is also known to exert its growth inhibitory effects through regulation of many noncyclooxygenase targets, including p21, beta-catenin, E-cadherin, mitochondrial apoptotic proteins, and peroxisome proliferator-activated receptor-gamma.	Sulindac	0-8	cadherin 1	Mus musculus	145-155
20716632-9	2010	We found that sulindac treatment protected against E-cadherin loss in colon tumors, with associated inhibition of nuclear beta-catenin accumulation.	Sulindac	14-22	cadherin 1	Mus musculus	51-61
20564330-6	2010	The histone deacetylase inhibitor trichostatin A (TSA) inhibited EMT; this was reflected by the preservation of epithelial markers and function (E-cadherin and albumin).	trichostatin A	50-53	cadherin 1	Mus musculus	145-155
20335317-13	2010	Expression of E-cadherin and vimentin paralleled in cells overexpressing RSOR/MIOX or subjected to high-glucose ambience.	high-glucose	99-111	cadherin 1	Mus musculus	14-24
20683022-0	2010	Curcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherin.	Curcumin	0-8	cadherin 1	Mus musculus	99-109
20683022-4	2010	We hypothesized that suppressing NF-kappaB by curcumin could up-regulate E-cadherin expression in NPC cells.	Curcumin	46-54	cadherin 1	Mus musculus	73-83
20683022-8	2010	RESULTS: With curcumin treatment, NF-kappaB was down-regulated and E-cadherin was up-regulated in NPC cells.	Curcumin	14-22	cadherin 1	Mus musculus	67-77
20683022-10	2010	CONCLUSION: Our results suggest that curcumin could be used in preventing NPC migration by suppressing NF-kappaB and activating E-cadherin expression.	Curcumin	37-45	cadherin 1	Mus musculus	128-138
20154713-10	2010	TMPP attenuated ultrastructural disruption caused by cTnT(R141W) expression and decreased expression of structural proteins myotilin and E-cadherin which were up-regulated in the cTnT(R141W) heart.	TMPP	0-4	cadherin 1	Mus musculus	137-147
19909744-8	2010	In mice, LY2109761 blocked metastasis of CRC cells to liver, inducing cancer cell expression of E-cadherin and reducing the expression of the tumorigenic proteins matrix metalloproteinase-9, nm23, urokinase plasminogen activator, and cyclooxygenase-2.	LY2109761	9-18	cadherin 1	Mus musculus	96-106
20164153-10	2010	Of interest, phosho-p38 levels were also elevated 2-fold in response to TRO and 2.3-fold to ROSI, but MAPK inhibition by PD98059 or SB203580 caused an additive inhibition of cell growth and did not alter E-cadherin or beta-catenin in response to TZDs.	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	121-128	cadherin 1	Mus musculus	204-214
20164153-10	2010	Of interest, phosho-p38 levels were also elevated 2-fold in response to TRO and 2.3-fold to ROSI, but MAPK inhibition by PD98059 or SB203580 caused an additive inhibition of cell growth and did not alter E-cadherin or beta-catenin in response to TZDs.	SB 203580	132-140	cadherin 1	Mus musculus	204-214
19628293-0	2010	Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells.	dithiolethione	0-14	cadherin 1	Mus musculus	58-68
19628293-0	2010	Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells.	Diclofenac	38-48	cadherin 1	Mus musculus	58-68
19628293-9	2010	By Western blot, S-valproate and S-diclofenac increased E-cadherin but reduced vimentin and ZEB1 (a transcriptional suppressor of E-cadherin) protein expression in NSCLC cells.	Valproic Acid	17-28	cadherin 1	Mus musculus	56-66
19628293-9	2010	By Western blot, S-valproate and S-diclofenac increased E-cadherin but reduced vimentin and ZEB1 (a transcriptional suppressor of E-cadherin) protein expression in NSCLC cells.	Valproic Acid	17-28	cadherin 1	Mus musculus	130-140
19628293-9	2010	By Western blot, S-valproate and S-diclofenac increased E-cadherin but reduced vimentin and ZEB1 (a transcriptional suppressor of E-cadherin) protein expression in NSCLC cells.	2-((2,6-dichlorophenyl)amino)benzeneacetic acid 4-(3H-1,2-dithiol-3-thione-5-yl)phenyl ester	33-45	cadherin 1	Mus musculus	56-66
19628293-9	2010	By Western blot, S-valproate and S-diclofenac increased E-cadherin but reduced vimentin and ZEB1 (a transcriptional suppressor of E-cadherin) protein expression in NSCLC cells.	2-((2,6-dichlorophenyl)amino)benzeneacetic acid 4-(3H-1,2-dithiol-3-thione-5-yl)phenyl ester	33-45	cadherin 1	Mus musculus	130-140
20385825-8	2010	MPSVII-EBs exibited elevated levels of hyaluronan and its receptor CD44, and markedly reduced expression levels of E-cadherin and cell-proliferating marker.	mpsvii-ebs	0-10	cadherin 1	Mus musculus	115-125
20025777-6	2009	However, exposure to the TbetaRI inhibitor SB431542, combined with the ROCK inhibitor Y27632, eliminated detectable actin stress fibers and mesenchymal gene expression while restoring epithelial E-cadherin and Kidney-specific cadherin (Ksp-cadherin) expression.	Y 27632	86-92	cadherin 1	Mus musculus	195-205
20026013-5	2010	Caerulein-exposed pancreatic acinar cells were immunohistochemically stained for claudin 4, cadherin 1, integrin beta 4, heat shock protein b1, and Serpinb6a.	Ceruletide	0-9	cadherin 1	Mus musculus	92-102
19779011-5	2009	Accordingly, in isolated colonic crypts pretreated with forskolin and carbachol for 10 min, respectively, and subjected to immunohistochemistry, the NBCe1 signal showed a markedly stronger colocalization with the E-cadherin signal, which was used as a membrane marker, compared with the untreated control.	Colforsin	56-65	cadherin 1	Mus musculus	213-223
20025777-6	2009	However, exposure to the TbetaRI inhibitor SB431542, combined with the ROCK inhibitor Y27632, eliminated detectable actin stress fibers and mesenchymal gene expression while restoring epithelial E-cadherin and Kidney-specific cadherin (Ksp-cadherin) expression.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	43-51	cadherin 1	Mus musculus	195-205
19779011-5	2009	Accordingly, in isolated colonic crypts pretreated with forskolin and carbachol for 10 min, respectively, and subjected to immunohistochemistry, the NBCe1 signal showed a markedly stronger colocalization with the E-cadherin signal, which was used as a membrane marker, compared with the untreated control.	Carbachol	70-79	cadherin 1	Mus musculus	213-223
19065634-5	2009	In addition, we induced cell death by employing photodynamic therapy, using Zn-phthalocyanine as a photosensitizer that targets E-cadherin adhesion complexes.	Zn(II)-phthalocyanine	76-93	cadherin 1	Mus musculus	128-138
19841737-14	2009	In addition, nicotine significantly reduced the expression of epithelial markers, E-Cadherin and beta-Catenin as well as the tight junction protein ZO-1; these tumors also showed an increased expression of the alpha(7) nAChR subunit.	Nicotine	13-21	cadherin 1	Mus musculus	82-92
19586906-9	2009	Intratracheal post-treatment with LPA (5 microm) reduced LPS-induced neutrophil influx, protein leak, and E-cadherin shedding in bronchoalveolar lavage fluids in a murine model of acute lung injury.	lysophosphatidic acid	34-37	cadherin 1	Mus musculus	106-116
19490989-6	2009	Exposure to TCDD during pregnancy reduced expression of the cell adhesion molecule E-cadherin in the mammary gland and decreased phosphorylation of STAT5, a known regulator of beta-casein gene expression.	Polychlorinated Dibenzodioxins	12-16	cadherin 1	Mus musculus	83-93
19318551-6	2009	Moreover, quantitative imaging has allowed us to assess the effects of therapeutic intervention on E-cadherin dynamics using dasatinib, a clinically approved Src inhibitor, and show clear differences in the efficacy of drug treatment in vivo.	Dasatinib	125-134	cadherin 1	Mus musculus	99-109
19544408-7	2009	Exposure of Ecad(-/-), EcadRNAi, and CHAVC-treated ES cells to the activin receptor-like kinase inhibitor SB431542 led to differentiation of the cells, which could be prevented by re-expression of E-cadherin.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	106-114	cadherin 1	Mus musculus	12-16
19544408-7	2009	Exposure of Ecad(-/-), EcadRNAi, and CHAVC-treated ES cells to the activin receptor-like kinase inhibitor SB431542 led to differentiation of the cells, which could be prevented by re-expression of E-cadherin.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	106-114	cadherin 1	Mus musculus	197-207
19097191-6	2009	Impaired myocardial formation is correlated with abnormal epithelial-to-mesenchymal transformation of the coelomic epithelium due to up-regulated E-cadherin and down-regulated RhoA, which are controlled by podoplanin.	podoplanin	206-216	cadherin 1	Mus musculus	146-156
19223545-4	2009	Here, we used N-methyl-N-nitrosourea (MNU) to promote gastric carcinogenesis in wild-type (wt) and cdh1(+/-) mice.	Methylnitrosourea	14-36	cadherin 1	Mus musculus	99-103
19223545-4	2009	Here, we used N-methyl-N-nitrosourea (MNU) to promote gastric carcinogenesis in wild-type (wt) and cdh1(+/-) mice.	Methylnitrosourea	38-41	cadherin 1	Mus musculus	99-103
18794357-6	2008	Treating cells with the AR ligand, dihydrotestosterone (DHT), triggered the reduction of E-cadherin expression and induced changes in cell morphology from an epithelial-like to a mesenchymal-like appearance.	Dihydrotestosterone	35-54	cadherin 1	Mus musculus	89-99
19047104-8	2008	Decreased levels of matrix metalloproteinases (MMP), snail-1, and vimentin, and an increased level of E-cadherin were also observed, indicating the anti-epithelial-mesenchymal transition effect of silibinin in tumors.	Silybin	197-206	cadherin 1	Mus musculus	102-112
18794357-6	2008	Treating cells with the AR ligand, dihydrotestosterone (DHT), triggered the reduction of E-cadherin expression and induced changes in cell morphology from an epithelial-like to a mesenchymal-like appearance.	Dihydrotestosterone	56-59	cadherin 1	Mus musculus	89-99
18242386-7	2008	We also found that etodolac suppressed tumor growth and induced E-cadherin expression and cell apoptosis in a T24 tumor xenograft mouse model.	Etodolac	19-27	cadherin 1	Mus musculus	64-74
19404440-5	2008	Mechanical stimulation of APC(1638N+) tissue leads to the phosphorylation of beta-catenin at tyrosine 654, the site of interaction with E-cadherin, as well as to increased nuclear localization of beta-catenin.	Tyrosine	93-101	cadherin 1	Mus musculus	136-146
18218692-4	2008	RNAi-mediated silencing of the adhesion molecule E-cadherin in confluent cells reduced glucose-stimulated secretion to the levels observed in isolated cells but had no impact on basal secretion.	Glucose	87-94	cadherin 1	Mus musculus	49-59
18218692-8	2008	The increased basal insulin secretion of dispersed cells is due to spontaneous Ca(2+) transients that activate downstream Ca(2+) effectors, whereas engagement of cell adhesion molecules including E-cadherin contributes to the greater secretory response to glucose seen in cells with normal intercellular contacts.	Glucose	256-263	cadherin 1	Mus musculus	196-206
17620337-7	2007	Moreover, knockdown of either ankyrin-G or beta-2-spectrin in one cell of a two-cell embryo blocks accumulation of E-cadherin at sites of cell-cell contact.	beta-2-spectrin	43-58	cadherin 1	Mus musculus	115-125
17620337-4	2007	Ankyrin-G also recruits beta-2-spectrin to E-cadherin-beta-catenin complexes, thus providing a direct connection between E-cadherin and the spectrin/actin skeleton.	beta-2-spectrin	24-39	cadherin 1	Mus musculus	43-53
17468512-5	2007	Incorporation of genistein in the diet significantly inhibited the activation of Akt, restored the activation of GSK-3beta, reduced cyclin D1 levels post-transcriptionally and maintained the expression of the cadherin-1 complex via down-regulation of snail-1.	Genistein	17-26	cadherin 1	Mus musculus	209-219
17620337-4	2007	Ankyrin-G also recruits beta-2-spectrin to E-cadherin-beta-catenin complexes, thus providing a direct connection between E-cadherin and the spectrin/actin skeleton.	beta-2-spectrin	24-39	cadherin 1	Mus musculus	121-131
17620337-5	2007	In addition to restricting the membrane mobility of E-cadherin, ankyrin-G and beta-2-spectrin also are required for exit of E-cadherin from the trans-Golgi network in a microtubule-dependent pathway.	beta-2-spectrin	78-93	cadherin 1	Mus musculus	124-134
17620337-6	2007	Ankyrin-G and beta-2-spectrin co-localize with E-cadherin in preimplantation mouse embryos.	beta-2-spectrin	14-29	cadherin 1	Mus musculus	47-57
17699770-0	2007	Sequential down-regulation of E-cadherin with squamous cell carcinoma progression: loss of E-cadherin via a prostaglandin E2-EP2 dependent posttranslational mechanism.	Dinoprostone	108-124	cadherin 1	Mus musculus	30-40
17699770-0	2007	Sequential down-regulation of E-cadherin with squamous cell carcinoma progression: loss of E-cadherin via a prostaglandin E2-EP2 dependent posttranslational mechanism.	Dinoprostone	108-124	cadherin 1	Mus musculus	91-101
17699770-7	2007	In both chronic and acute UV injury, E-cadherin levels declined at a time when epidermal PGE2 synthesis was enhanced.	Dinoprostone	89-93	cadherin 1	Mus musculus	37-47
17699770-9	2007	In contrast, addition of PGE2 or the EP2 receptor agonist butaprost to PMK produced a dose- and time-dependent decrease in E-cadherin.	Dinoprostone	25-29	cadherin 1	Mus musculus	123-133
17699770-9	2007	In contrast, addition of PGE2 or the EP2 receptor agonist butaprost to PMK produced a dose- and time-dependent decrease in E-cadherin.	butaprost	58-67	cadherin 1	Mus musculus	123-133
17699770-10	2007	We also show that UV irradiation, via the PGE2-EP2 signaling pathway, may initiate tumorigenesis in keratinocytes by down-regulating E-cadherin-mediated cell-cell contacts through its mobilization away from the cell membrane, internalization into the cytoplasm, and shuttling through the lysosome and proteasome degradation pathways.	Dinoprostone	42-46	cadherin 1	Mus musculus	133-143
17699770-11	2007	Further understanding of how UV-PGE2-EP2 down-regulates E-cadherin may lead to novel chemopreventative strategies for the treatment of skin and other epithelial cancers.	Dinoprostone	32-36	cadherin 1	Mus musculus	56-66
17605082-5	2007	We show herein the unequivocal identification of oval cells in paraffin-embedded mouse liver samples based on strong E-cadherin expression different from that of hepatocytes and bile duct cells.	Paraffin	63-71	cadherin 1	Mus musculus	117-127
17015477-5	2006	In addition, we demonstrate that expression of E-cadherin, a protein involved in the control of cell migration and invasion, is highly up-regulated in the presence of valproic acid and pioglitazone.	Valproic Acid	167-180	cadherin 1	Mus musculus	47-57
17481582-5	2007	In addition, F9 Ecad (-/-) and D3M Ecad (-/-) cells displayed strong adhesion to plates coated with Le(x) glycosphingolipid (III(3)FucnLc4Cer), in dose-dependent manner, in the presence of Ca(2+).	Glycosphingolipids	106-123	cadherin 1	Mus musculus	16-20
17481582-5	2007	In addition, F9 Ecad (-/-) and D3M Ecad (-/-) cells displayed strong adhesion to plates coated with Le(x) glycosphingolipid (III(3)FucnLc4Cer), in dose-dependent manner, in the presence of Ca(2+).	Glycosphingolipids	106-123	cadherin 1	Mus musculus	35-39
17082242-5	2006	Paricalcitol largely preserved E-cadherin and reduced alpha-smooth muscle actin expression in vivo.	paricalcitol	0-12	cadherin 1	Mus musculus	31-41
17082242-7	2006	In vitro, paricalcitol abolished TGF-beta1-mediated E-cadherin suppression and alpha-smooth muscle actin and fibronectin induction in tubular epithelial cells, underscoring its ability to block directly the epithelial to mesenchymal transition (EMT).	paricalcitol	10-22	cadherin 1	Mus musculus	52-62
16950554-5	2006	We found that the relative proportion of ECRA(90), as compared to intact E-cadherin, was higher in colon extracts from control mice than from YTX-treated animals, indicating that oral administration of YTX to mice stabilizes E-cadherin of mouse colon.	Homovanillic Acid	202-205	cadherin 1	Mus musculus	225-235
17030180-6	2006	Activated KRAS is known to induce tyrosine phosphorylation of beta-catenin, leading to its release from E-cadherin at the adherens junction.	Tyrosine	34-42	cadherin 1	Mus musculus	104-114
16966325-9	2006	Furthermore, elimination of reactive oxygen species (ROS) blocked expression of snail and subsequently derepressed E-cadherin expression.	Reactive Oxygen Species	28-51	cadherin 1	Mus musculus	115-125
16966325-9	2006	Furthermore, elimination of reactive oxygen species (ROS) blocked expression of snail and subsequently derepressed E-cadherin expression.	Reactive Oxygen Species	53-56	cadherin 1	Mus musculus	115-125
17011554-5	2006	Progesterone induced expression of E-cadherin and 17beta-estradiol regulated the expression of catenin in implantation-delayed uteri.	Progesterone	0-12	cadherin 1	Mus musculus	35-45
17015477-5	2006	In addition, we demonstrate that expression of E-cadherin, a protein involved in the control of cell migration and invasion, is highly up-regulated in the presence of valproic acid and pioglitazone.	Pioglitazone	185-197	cadherin 1	Mus musculus	47-57
16368433-4	2006	We treated Apc+/+ (WT) littermate small intestine with EGTA, an inhibitor of E-cadherin, and with LPA, an RhoA activator; both induced effects on adhesion and kinase activity that mimicked the Min/+ phenotype.	Egtazic Acid	55-59	cadherin 1	Mus musculus	77-87
16272459-5	2006	Reduced E-cadherin expression after 6 d of BHT and hyperoxia was accompanied by enhanced expression and nuclear localization of beta-catenin and increased integrin-linked kinase-1 expression during subsequent normoxic recovery.	Butylated Hydroxytoluene	43-46	cadherin 1	Mus musculus	8-18
16288056-7	2005	administration of EGCG resulted in increased levels of E-cadherin and decreased levels of nuclear beta-catenin, c-Myc, phospho-Akt, and phospho-extracellular signal-regulated kinase 1/2 (ERK1/2) in small intestinal tumors.	epigallocatechin gallate	18-22	cadherin 1	Mus musculus	55-65
16199027-11	2005	Cells derived from blastomeres injected with morpholino-oligonucleotide had a reduced amount of vezatin concomitantly with a decrease in the quantity of E-cadherin and beta-catenin localized in the areas of intercellular contact.	Morpholinos	45-71	cadherin 1	Mus musculus	153-163
15880654-6	2005	We report that under apoptotic conditions, ZnPc phototreatment induces a rapid disorganization of the E-cadherin mediated cell-cell adhesion, which largely preceded both the detachment of cells from the substrate, via beta-1 integrins and the induction of apoptotic mitochondrial markers.	Zn(II)-phthalocyanine	43-47	cadherin 1	Mus musculus	102-112
15880654-9	2005	These results strongly suggest that the E-cadherin adhesion complex could be the primary target of ZnPc phototreatment, and that loss of E-cadherin mediated cell adhesion after early photodamage triggers an apoptotic response.	Zn(II)-phthalocyanine	99-103	cadherin 1	Mus musculus	40-50
16138831-0	2005	Polyamines are involved in murine kidney development controlling expression of c-ret, E-cadherin, and Pax2/8 genes.	Polyamines	0-10	cadherin 1	Mus musculus	86-96
15621251-7	2005	Cx32 and E-cadherin genes in AL/XG capsules were more rapidly reexpressed and expressed, respectively, than in AL ones.	Aluminum	29-31	cadherin 1	Mus musculus	9-19
15953529-3	2005	In this study, we examined changes of E-cadherin expression in mouse vestibular epithelia following local application of neomycin using immunohistochemistry and western blotting, and morphology of cell-cell junctions by transmission electron microscopy (TEM).	Neomycin	121-129	cadherin 1	Mus musculus	38-48
15882265-5	2005	By day 14, the expression of two normal tubular proteins, E-cadherin and Ksp-cadherin, were significantly lower in the PAI-1 tg mice (3.2 +/- 0.5% vs. 11.7 +/- 5.9% and 2.6 +/- 1.6) vs. 6.2 +/- 0.8%, respectively), implying more extensive tubular damage.	Thioguanine	125-127	cadherin 1	Mus musculus	58-68
15579483-10	2005	Immunoprecipitation and immunohistochemistry analyses showed that impaired association of the adherens junction proteins E-cadherin and beta-catenin in Min/+ mice was improved by treatment with either E(2) or coumestrol.	Estradiol	201-205	cadherin 1	Mus musculus	121-131
15917479-6	2005	Surface marker analysis revealed that the sorted SP cells expressed alpha6-integrin, beta1-integrin, Sca-1, keratin 14, and keratin 19, which are proliferating and progenitor cell markers, at levels higher than in non-SP cells, while they expressed E-cadherin, CD34, and CD71 at lower levels.	sp	49-51	cadherin 1	Mus musculus	249-259
15775979-5	2005	Here we show that loss of E-cadherin in the epidermis in vivo results in perinatal death of mice due to the inability to retain a functional epidermal water barrier.	Water	151-156	cadherin 1	Mus musculus	26-36
15579483-10	2005	Immunoprecipitation and immunohistochemistry analyses showed that impaired association of the adherens junction proteins E-cadherin and beta-catenin in Min/+ mice was improved by treatment with either E(2) or coumestrol.	Coumestrol	209-219	cadherin 1	Mus musculus	121-131
15723683-5	2005	Mn2+ promoted adhesion of S39T-BMMC to the monolayer of E-cadherin+F9 cells.	Manganese(2+)	0-4	cadherin 1	Mus musculus	56-66
15705912-4	2005	Here, we confirm these findings and show that treatment of Min/+ intestinal tissue with carnosol restored both E-cadherin and beta-catenin to these enterocyte membranes, yielding a phenotype similar to that of the Apc(+/+) wild-type (WT) littermate.	carnosol	88-96	cadherin 1	Mus musculus	111-121
15705912-5	2005	Moreover, treatment of WT intestine with the phosphatase inhibitor, pervanadate, removed E-cadherin and beta-catenin from the lateral membranes of enterocytes, mimicking the appearance of the Min/+ tissue.	pervanadate	68-79	cadherin 1	Mus musculus	89-99
15705912-8	2005	Moreover, these data suggest that carnosol prevents Apc-associated intestinal tumorigenesis, potentially via its ability to enhance E-cadherin-mediated adhesion and suppress beta-catenin tyrosine phosphorylation.	carnosol	34-42	cadherin 1	Mus musculus	132-142
15476585-9	2004	MATERIALS AND METHODS: It has been previously reported that N-cadherin-expressing E-cadherin-/- ES transfectants formed neuroepithelium and cartilage in teratomas.	Einsteinium	96-98	cadherin 1	Mus musculus	82-92
15671539-9	2005	GTP feeding to TRAMP mice resulted in marked inhibition of prostate cancer progression, which was associated with reduction of S100A4 and restoration of E-cadherin.	Guanosine Triphosphate	0-3	cadherin 1	Mus musculus	153-163
12759241-6	2003	E-cadherin ectodomain was shed into the bronchoalveolar lavage fluid of bleomycin-injured wild-type mice, but was not shed in matrilysin-null mice.	Bleomycin	72-81	cadherin 1	Mus musculus	0-10
15161659-2	2004	Similar cytoplasmic localization of p120ctn and growth factor-induced accumulation of tyrosine-phosphorylated p120ctn in the protrusive domain were observed in E-cadherin-deficient breast cancer cells.	Tyrosine	86-94	cadherin 1	Mus musculus	160-170
14627720-5	2003	We found that the expression of a calcium-dependent cell adhesion molecule, E-cadherin, is restricted to the proximal region of extra-embryonic mesoderm that contains PGC precursors, and that blocking the functions of E-cadherin with an antibody inhibits PGC formation in vitro.	Calcium	34-41	cadherin 1	Mus musculus	76-86
14627720-5	2003	We found that the expression of a calcium-dependent cell adhesion molecule, E-cadherin, is restricted to the proximal region of extra-embryonic mesoderm that contains PGC precursors, and that blocking the functions of E-cadherin with an antibody inhibits PGC formation in vitro.	Calcium	34-41	cadherin 1	Mus musculus	218-228
15065602-0	2004	5-aza-2"-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis.	Decitabine	0-22	cadherin 1	Mus musculus	36-46
15065602-0	2004	5-aza-2"-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis.	Decitabine	0-22	cadherin 1	Mus musculus	57-67
15065602-3	2004	The present study was designed to test the hypothesis that the demethylating agent 5-aza-2"-deoxycytidine (AZA) can restore the E-cadherin system and reduce the potential for metastasis.	Decitabine	83-105	cadherin 1	Mus musculus	128-138
15065602-3	2004	The present study was designed to test the hypothesis that the demethylating agent 5-aza-2"-deoxycytidine (AZA) can restore the E-cadherin system and reduce the potential for metastasis.	Decitabine	107-110	cadherin 1	Mus musculus	128-138
15065602-7	2004	The AZA treatment suppressed both growth of the primary tumor and lung metastasis in comparison with untreated controls, suggesting that the suppression of metastasis may be, at least partly, attributable to restoration of E-cadherin expression.	Decitabine	4-7	cadherin 1	Mus musculus	223-233
14566820-4	2003	Our results also show that cAMP and forskolin are able to abolish the TGF-beta1-induced reorganization of the actin cytoskeleton that is characteristic of the mesenchymal phenotype and also inhibits the disruption of the E-cadherin cell to cell interactions.	Cyclic AMP	27-31	cadherin 1	Mus musculus	221-231
14566820-4	2003	Our results also show that cAMP and forskolin are able to abolish the TGF-beta1-induced reorganization of the actin cytoskeleton that is characteristic of the mesenchymal phenotype and also inhibits the disruption of the E-cadherin cell to cell interactions.	Colforsin	36-45	cadherin 1	Mus musculus	221-231
14654215-0	2003	Morpholino oligonucleotide-triggered knockdown reveals a role for maternal E-cadherin during early mouse development.	Morpholinos	0-26	cadherin 1	Mus musculus	75-85
14578588-0	2003	Taxol inhibits melanoma metastases through apoptosis induction, angiogenesis inhibition, and restoration of E-cadherin and nm23 expression.	Paclitaxel	0-5	cadherin 1	Mus musculus	108-118
14578588-9	2003	Conversely, Taxol increased the expression of E-cadherin and nm23.	Paclitaxel	12-17	cadherin 1	Mus musculus	46-56
12391285-6	2002	Increased expression of PPARgamma, as well as ciglitazone and sulindac sulfide induced expression of E-cadherin, which has been linked to increased differentiation of NSCLC.	ciglitazone	46-57	cadherin 1	Mus musculus	101-111
12756972-15	2003	The DMH is therefore a useful model for studying the abnormalities of the E-cadherin-catenin pathway in colorectal carcinogenesis.	1,2-Dimethylhydrazine	4-7	cadherin 1	Mus musculus	74-84
12678405-0	2003	Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and E-cadherin.	Curcumin	0-8	cadherin 1	Mus musculus	127-137
12678405-8	2003	Curcumin enhances the expression of antimetastatic proteins, tissue inhibitor metalloproteinase (TIMP)-2, nonmetastatic gene 23 (Nm23), and E-cadherin.	Curcumin	0-8	cadherin 1	Mus musculus	140-150
12678405-9	2003	In this article we report on the effect of curcumin on the expression of integrin, TIMP-2, Nm23, E-cadherin, adhesion, and metalloproteinase activity.	Curcumin	43-51	cadherin 1	Mus musculus	97-107
12511569-0	2003	E-cadherin negatively regulates CD44-hyaluronan interaction and CD44-mediated tumor invasion and branching morphogenesis.	Hyaluronic Acid	37-47	cadherin 1	Mus musculus	0-10
12507936-8	2002	Co-treatment with NO donors and broad-spectrum matrix metalloproteinase (MMP) inhibitors TIMP-1 (100 ng/ml), GM6001 (10 micro M) and GM1489 (10 micro M) abolished the degradation of E-cadherin induced by NO as demonstrated by western blot analysis.	N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide	109-115	cadherin 1	Mus musculus	182-192
12507936-8	2002	Co-treatment with NO donors and broad-spectrum matrix metalloproteinase (MMP) inhibitors TIMP-1 (100 ng/ml), GM6001 (10 micro M) and GM1489 (10 micro M) abolished the degradation of E-cadherin induced by NO as demonstrated by western blot analysis.	GM 1489	133-139	cadherin 1	Mus musculus	182-192
12391285-6	2002	Increased expression of PPARgamma, as well as ciglitazone and sulindac sulfide induced expression of E-cadherin, which has been linked to increased differentiation of NSCLC.	sulindac sulfide	62-78	cadherin 1	Mus musculus	101-111
12165405-2	2002	The distribution of E-cadherin and beta-catenin was immunohistochemically examined in normal and aminoglycoside-treated utricles of mice.	Aminoglycosides	97-111	cadherin 1	Mus musculus	20-30
12065577-3	2002	Here, we report that a rapid and transient tyrosine phosphorylation of Cas is induced by TGF-beta 1 and that E-cadherin-mediated cell-cell interaction and the Src kinase pathway are involved in this early TGF-beta signaling.	Tyrosine	43-51	cadherin 1	Mus musculus	109-119
12356578-2	2002	E-cadherin immunoreactivity was detected continuously along neighboring epithelial cell borders and between adjacent alveolar epithelial cells in naive and saline-challenged mice.	Sodium Chloride	156-162	cadherin 1	Mus musculus	0-10
12165405-7	2002	These findings suggest that the E-cadherin-beta-catenin complex plays roles in degeneration and subsequent repair processes in vestibular epithelia affected by aminoglycosides.	Aminoglycosides	160-175	cadherin 1	Mus musculus	32-42
11749037-2	2001	E-Cadherin, a calcium-dependent adhesion molecule, is also expressed in myelinating Schwann cells in the PNS and is involved in forming adherens junctions between adjacent loops of membrane at the paranode.	Calcium	14-21	cadherin 1	Mus musculus	0-10
12042641-8	2002	RESULTS: Rapamycin conditioning of renal cancer cells upregulated E-cadherin expression and induced phenotypic transition from invasive spindle, or dome-shaped cells, with exploratory pseudopodia to noninvasive cuboidal cells that formed cell-to-cell adhesions.	Sirolimus	9-18	cadherin 1	Mus musculus	66-76
11756330-5	2002	Blockade of E-cadherin-mediated cell adhesion in pancreatic islets abolished the glucose-stimulated increases in intracellular Ca(2+) levels and insulin secretion, suggesting that loss of E-cadherin in beta-cells is associated with impaired insulin secretion.	Glucose	81-88	cadherin 1	Mus musculus	12-22
11756330-5	2002	Blockade of E-cadherin-mediated cell adhesion in pancreatic islets abolished the glucose-stimulated increases in intracellular Ca(2+) levels and insulin secretion, suggesting that loss of E-cadherin in beta-cells is associated with impaired insulin secretion.	Glucose	81-88	cadherin 1	Mus musculus	188-198
11640887-2	2001	The E-cadherin gene-transfected cells (P3E1) communicate in a calcium-dependent manner and they were used to study how E-cadherin restores the function of connexins.	Calcium	62-69	cadherin 1	Mus musculus	4-14
11495912-5	2001	Furthermore, glycine-extended gastrin(17) induced a PI3-kinase-mediated tyrosine phosphorylation of the adherens junction protein beta-catenin, partial dissociation of the complex between beta-catenin and the transmembrane protein E-cadherin, and delocalization of beta-catenin into the cytoplasm.	Glycine	13-20	cadherin 1	Mus musculus	231-241
11640887-9	2001	These results suggest that E-cadherin junction formation at high calcium leads to formation of actin cables, which directly or indirectly transport connexins from the cytoplasm to the cell-cell contact membranes via the Golgi apparatus.	Calcium	65-72	cadherin 1	Mus musculus	27-37
11306447-0	2001	Highly specific tumor binding of a 213Bi-labeled monoclonal antibody against mutant E-cadherin suggests its usefulness for locoregional alpha-radioimmunotherapy of diffuse-type gastric cancer.	213bi	35-40	cadherin 1	Mus musculus	84-94
11306447-3	2001	After intratumoral application in s.c. tumors expressing mutant E-cadherin, the 213Bi-labeled antibody was specifically retained at the injection site as shown by autoradiography.	213bi	80-85	cadherin 1	Mus musculus	64-74
11306447-7	2001	The selective binding of the 213Bi-labeled, mutation-specific monoclonal antibody E-cadherin delta 9-1 suggests that it will be successful for alpha-radioimmunotherapy of disseminated tumors after locoregional application.	213bi	29-34	cadherin 1	Mus musculus	82-92
11024053-0	2001	The addition of bisecting N-acetylglucosamine residues to E-cadherin down-regulates the tyrosine phosphorylation of beta-catenin.	Acetylglucosamine	26-45	cadherin 1	Mus musculus	58-68
11024053-0	2001	The addition of bisecting N-acetylglucosamine residues to E-cadherin down-regulates the tyrosine phosphorylation of beta-catenin.	Tyrosine	88-96	cadherin 1	Mus musculus	58-68
11024053-5	2001	An addition of bisecting GlcNAc residues to E-cadherin leads to an alteration in cell morphology and the localization of beta-catenin after epidermal growth factor stimulation.	Acetylglucosamine	25-31	cadherin 1	Mus musculus	44-54
11024053-9	2001	Thus, the addition of a specific N-glycan structure, the bisecting GlcNAc to E-cadherin-beta-catenin complex, down-regulates the intracellular signaling pathway, suggesting its implication in cell motility and the suppression of cancer metastasis.	n-glycan	33-41	cadherin 1	Mus musculus	77-87
11024053-9	2001	Thus, the addition of a specific N-glycan structure, the bisecting GlcNAc to E-cadherin-beta-catenin complex, down-regulates the intracellular signaling pathway, suggesting its implication in cell motility and the suppression of cancer metastasis.	Acetylglucosamine	67-73	cadherin 1	Mus musculus	77-87
10541288-5	1999	Also, using immunofluorescence microscopy it was demonstrated that ATP depletion results in a marked diminution of E-cadherin staining in the basolateral membrane of MPT cells.	Adenosine Triphosphate	67-70	cadherin 1	Mus musculus	115-125
11058443-1	2000	Epithelial cadherin (E-cadherin) is a member of the cadherin family of calcium-dependent cell adhesion molecules and is present in the ovary.	Calcium	71-78	cadherin 1	Mus musculus	11-19
11016639-9	2000	The protein expression of antimetastases markers, i.e., E-cadherin and alpha- and beta-catenin, was found to be restored in DFMO-fed animals as compared with the non-DFMO-fed mice.	Eflornithine	124-128	cadherin 1	Mus musculus	56-66
10807587-7	2000	A His-Ala-Val (HAV)-containing peptide that inhibits homophilic E-cadherin binding prevented cell-cell aggregation and promoted apoptosis of MPT cells in suspension.	His-Ala-Val	2-13	cadherin 1	Mus musculus	64-74
10807587-7	2000	A His-Ala-Val (HAV)-containing peptide that inhibits homophilic E-cadherin binding prevented cell-cell aggregation and promoted apoptosis of MPT cells in suspension.	HYDROXYAMINOVALINE	15-18	cadherin 1	Mus musculus	64-74
10629227-4	2000	Most of the beta-catenin and p120(ctn) remained in a complex with E-cadherin at the membrane, but a minor fraction of uncomplexed cytoplasmic beta-catenin increased significantly.	trans-crotonin	34-37	cadherin 1	Mus musculus	66-76
10629227-5	2000	The epithelial-mesenchymal cell conversion induced by prolonged estradiol treatment was accompanied by a complete loss of E-cadherin expression, a 70% reduction in beta-catenin protein level, and a change in the expression pattern of p120(ctn) isoforms.	Estradiol	64-73	cadherin 1	Mus musculus	122-132
11045574-8	2000	Addition of a blocking antibody of homophilic E-cadherin interactions, or a synthetic E-cadherin-binding decapeptide containing the histidine-alanine-valine (HAV) sequence in methylcellulose cultures of gut intraepithelial mononuclear cells or BMMC, significantly suppressed the clonal growth of mast cells.	HYDROXYAMINOVALINE	158-161	cadherin 1	Mus musculus	86-96
10541288-6	1999	Vanadate mimics this effect of ATP depletion, whereas genistein ameliorates the reduction in the intensity of E-cadherin staining induced by ATP depletion.	Adenosine Triphosphate	141-144	cadherin 1	Mus musculus	110-120
10446391-0	1999	Interaction of cadmium (Cd(2+)) with a 13-residue polypeptide analog of a putative calcium-binding motif of E-cadherin.	Cadmium	15-22	cadherin 1	Mus musculus	108-118
10496679-8	1999	Disruption of the E-cadherin/catenin complex by tBHP, but not DA, correlated with enhanced tyrosine phosphorylation of beta-catenin.	tert-Butylhydroperoxide	48-52	cadherin 1	Mus musculus	18-28
10496679-8	1999	Disruption of the E-cadherin/catenin complex by tBHP, but not DA, correlated with enhanced tyrosine phosphorylation of beta-catenin.	Tyrosine	91-99	cadherin 1	Mus musculus	18-28
10446391-0	1999	Interaction of cadmium (Cd(2+)) with a 13-residue polypeptide analog of a putative calcium-binding motif of E-cadherin.	Calcium	83-90	cadherin 1	Mus musculus	108-118
10457201-5	1999	Adhesion of MTC-1 cells to E-cadherin-Fc was inhibited by arginine-glycine-aspartate (RGD) peptides and vice versa cells bound to immobilized RGD polymer in an M290-dependent fashion, where adhesion was inhibitable with soluble E-cadherin-Fc.	Glycine	67-74	cadherin 1	Mus musculus	27-37
8841417-0	1996	Estradiol induces E-cadherin degradation in mouse uterine epithelium during the estrous cycle and early pregnancy.	Estradiol	0-9	cadherin 1	Mus musculus	18-28
11775815-2	1999	METHODS: Immunohistochemistry SP technique was used to examine E-cd expression on epithelial cells of respiratory tract in smoking mice of different stages and dosages and the morphological changes observed by light and electron microscopy respectively.	TFF2 protein, human	30-32	cadherin 1	Mus musculus	63-67
9759521-3	1998	Biotin-labelling studies have shown that both types of E-cadherin complexes are present at the surface of confluent cells.	Biotin	0-6	cadherin 1	Mus musculus	55-65
10406800-3	1999	By a series of domain-swapping and mutagenesis experiments, we identify Pro16 of E-cadherin as a residue critical for specificity: a Pro--&gt;Glu substitution in human E-cadherin totally abrogates interaction, whereas a Glu--&gt;Pro substitution in mouse E-cadherin results in a complete gain of function.	Glutamic Acid	142-145	cadherin 1	Mus musculus	168-178
9950951-5	1999	E-cadherin mediates calcium-dependent homotypic cell-cell interactions that are stabilized by its association with catenins and the actin cytoskeleton.	Calcium	20-27	cadherin 1	Mus musculus	0-10
9802904-2	1998	Based on studies with cultured kidney cells, we have hypothesized that a mechanism for restricting Na/K-ATPase to the basal-lateral membrane involves E-cadherin-mediated cell-cell adhesion and integration of Na/K-ATPase into the Triton X-100-insoluble ankyrin- and spectrin-based membrane cytoskeleton.	Octoxynol	229-241	cadherin 1	Mus musculus	150-160
9628900-5	1998	Treatment of E-cadherin complexes with tyrosine-specific phosphatase reveals that the strength of alpha-catenin association is directly dependent on tyrosine phosphorylation.	Tyrosine	39-47	cadherin 1	Mus musculus	13-23
9628900-7	1998	The Fyn tyrosine kinase colocalizes with E-cadherin at the cell membrane in calcium-treated keratinocytes.	Calcium	76-83	cadherin 1	Mus musculus	41-51
9585257-5	1998	The E-cadherin/catenin complexes present in the double transfectants were functional in calcium-dependent aggregation assays and similar in composition to those of control keratinocytes.	Calcium	88-95	cadherin 1	Mus musculus	4-14
9057087-1	1997	Expression of the calcium-dependent adhesion molecule E-cadherin suppresses the invasion of cells in vitro, but the mechanism of this effect is unknown.	Calcium	18-25	cadherin 1	Mus musculus	54-64
8841417-9	1996	The E2 effect also was mimicked by the action on isolated epithelium of monoclonal antibody against the calcium-dependent cell adhesion molecule, E-cadherin, suggesting that inactivation of E-cadherin was induced by E2.	Calcium	104-111	cadherin 1	Mus musculus	146-156
8841417-9	1996	The E2 effect also was mimicked by the action on isolated epithelium of monoclonal antibody against the calcium-dependent cell adhesion molecule, E-cadherin, suggesting that inactivation of E-cadherin was induced by E2.	Calcium	104-111	cadherin 1	Mus musculus	190-200
7629992-3	1995	To this cell line, mouse E-cadherin cDNA in a expression vector was co-transfected with a neomycin-resistant gene.	Neomycin	90-98	cadherin 1	Mus musculus	25-35
8637391-0	1996	Binding of cadmium (Cd2+) to E-CAD1, a calcium-binding polypeptide analog of E-cadherin.	Cadmium	11-18	cadherin 1	Mus musculus	77-87
8637391-0	1996	Binding of cadmium (Cd2+) to E-CAD1, a calcium-binding polypeptide analog of E-cadherin.	Calcium	39-46	cadherin 1	Mus musculus	77-87
8519694-9	1995	Tg and CPA also inhibit the expression of mRNA and protein for specific epidermal spinous cell markers, keratins 1 (K1) and 10 (K10), prevent the redistribution of E-cadherin from a diffuse membranous pattern to concentration at cell-cell junctions, and inhibit the activation of a reporter gene regulated by a K1 enhancer element shown previously to be Ca2+ sensitive.	Thapsigargin	0-2	cadherin 1	Mus musculus	164-174
8519694-9	1995	Tg and CPA also inhibit the expression of mRNA and protein for specific epidermal spinous cell markers, keratins 1 (K1) and 10 (K10), prevent the redistribution of E-cadherin from a diffuse membranous pattern to concentration at cell-cell junctions, and inhibit the activation of a reporter gene regulated by a K1 enhancer element shown previously to be Ca2+ sensitive.	cyclopiazonic acid	7-10	cadherin 1	Mus musculus	164-174
8706259-4	1996	BoP strongly decreased the amount of E-cadherin protein and the level occurring in the membranes in both cell lines, whereas TPA caused a translocation of E-cadherin from the membrane towards the cytosol, without decreasing the total amount of E-cadherin present.	Benzoyl Peroxide	0-3	cadherin 1	Mus musculus	37-47
8706259-4	1996	BoP strongly decreased the amount of E-cadherin protein and the level occurring in the membranes in both cell lines, whereas TPA caused a translocation of E-cadherin from the membrane towards the cytosol, without decreasing the total amount of E-cadherin present.	Tetradecanoylphorbol Acetate	125-128	cadherin 1	Mus musculus	155-165
8706259-4	1996	BoP strongly decreased the amount of E-cadherin protein and the level occurring in the membranes in both cell lines, whereas TPA caused a translocation of E-cadherin from the membrane towards the cytosol, without decreasing the total amount of E-cadherin present.	Tetradecanoylphorbol Acetate	125-128	cadherin 1	Mus musculus	155-165
8615670-3	1996	Conophylline did not increase expression of fibronectin but induced E-cadherin expression in K-ras-NIH3T3 cells.	conophylline	0-12	cadherin 1	Mus musculus	68-78
7528244-4	1995	In contrast, in the PAMcN390 delta cells, which showed retarded translocation of E-cadherin, the redistribution of desmoplakin and the rearrangement of keratin filaments were delayed as late as 24 h after the calcium elevation.	Calcium	209-216	cadherin 1	Mus musculus	81-91
7582920-11	1995	Proteolytic processing of both newly synthesised and total uvomorulin to generate mature molecule from precursor increased within 30 min to 1 h after activation, and also occurred in the continued presence of brefeldin, suggesting that uvomorulin processing appears to be controlled independently of its surface expression.	brefeldin	209-218	cadherin 1	Mus musculus	59-69
7929642-5	1994	6-dimethylaminopurine-induced premature flattening is inhibited when the embryos are cultured in the presence of an anti-E-cadherin antibody or without extra-cellular Ca2+, demonstrating that this process requires functional E-cadherin; whereas cell flattening and gap junction formation take place in the absence of E-cadherin phosphorylation, suggesting that its phosphorylation is not required normally for these events.	N(6),N(6)-dimethyladenine	0-21	cadherin 1	Mus musculus	121-131
7957569-5	1994	Immunohistochemical studies confirmed that E-cadherin was expressed by DC in skin-associated LN in situ, and demonstrated that the number of E-cadherin+ DC in LN draining skin previously treated with the contact allergen 2,4,6-trinitrochlorobenzene was increased relative to the number of E-cadherin+ DC present in LN draining normal skin.	Picryl Chloride	221-248	cadherin 1	Mus musculus	43-53
7957569-5	1994	Immunohistochemical studies confirmed that E-cadherin was expressed by DC in skin-associated LN in situ, and demonstrated that the number of E-cadherin+ DC in LN draining skin previously treated with the contact allergen 2,4,6-trinitrochlorobenzene was increased relative to the number of E-cadherin+ DC present in LN draining normal skin.	Picryl Chloride	221-248	cadherin 1	Mus musculus	141-151
7957569-5	1994	Immunohistochemical studies confirmed that E-cadherin was expressed by DC in skin-associated LN in situ, and demonstrated that the number of E-cadherin+ DC in LN draining skin previously treated with the contact allergen 2,4,6-trinitrochlorobenzene was increased relative to the number of E-cadherin+ DC present in LN draining normal skin.	Picryl Chloride	221-248	cadherin 1	Mus musculus	141-151
7957569-6	1994	DC propagated from the blood of cyclophosphamide-treated mice in granulocyte/macrophage-colony stimulating factor-supplemented media also expressed E-cadherin.	Cyclophosphamide	32-48	cadherin 1	Mus musculus	148-158
7957569-7	1994	E-cadherin immunoprecipitated from DC co-migrated in SDS polyacrylamide gels with that from fibroblasts transfected with murine E-cadherin cDNA, and mRNA encoding extracellular and intracellular regions of E-cadherin was present in DC propagated from blood.	Sodium Dodecyl Sulfate	53-56	cadherin 1	Mus musculus	0-10
7957569-7	1994	E-cadherin immunoprecipitated from DC co-migrated in SDS polyacrylamide gels with that from fibroblasts transfected with murine E-cadherin cDNA, and mRNA encoding extracellular and intracellular regions of E-cadherin was present in DC propagated from blood.	polyacrylamide	57-71	cadherin 1	Mus musculus	0-10
7954333-3	1994	As E-cadherin is a major Ca2+ dependent adhesion molecule, involved in cell-cell adhesion, differentiation and polarity of normal and cancerous epithelial cells, we decided to investigate its involvement in the CDR mechanism.	cdr	211-214	cadherin 1	Mus musculus	3-13
8039302-0	1994	Estradiol regulates E-cadherin mRNA levels in the surface epithelium of the mouse ovary.	Estradiol	0-9	cadherin 1	Mus musculus	20-30
8039302-1	1994	E-cadherin is a calcium-dependent cell adhesion molecule which is present in the surface epithelium of the mouse ovary.	Calcium	16-23	cadherin 1	Mus musculus	0-10
8039302-4	1994	We have examined the ability of steroids to influence ovarian E-cadherin mRNA levels in vivo.	Steroids	32-40	cadherin 1	Mus musculus	62-72
8039302-6	1994	Only 17-beta estradiol caused a rapid and significant increase in the ovarian E-cadherin mRNA levels.	Estradiol	5-22	cadherin 1	Mus musculus	78-88
8039302-7	1994	We speculate that this steroid is a key regulator of E-cadherin-mediated epithelial cell interactions in vivo.	Steroids	23-30	cadherin 1	Mus musculus	53-63
7929642-5	1994	6-dimethylaminopurine-induced premature flattening is inhibited when the embryos are cultured in the presence of an anti-E-cadherin antibody or without extra-cellular Ca2+, demonstrating that this process requires functional E-cadherin; whereas cell flattening and gap junction formation take place in the absence of E-cadherin phosphorylation, suggesting that its phosphorylation is not required normally for these events.	N(6),N(6)-dimethyladenine	0-21	cadherin 1	Mus musculus	225-235
7929642-5	1994	6-dimethylaminopurine-induced premature flattening is inhibited when the embryos are cultured in the presence of an anti-E-cadherin antibody or without extra-cellular Ca2+, demonstrating that this process requires functional E-cadherin; whereas cell flattening and gap junction formation take place in the absence of E-cadherin phosphorylation, suggesting that its phosphorylation is not required normally for these events.	N(6),N(6)-dimethyladenine	0-21	cadherin 1	Mus musculus	225-235
8298032-7	1993	Calcium-induced differentiation decreases the sum of the percentages of molecules in the directed diffusion and the stationary modes outside of the cell-cell contact regions on the cell surface (which is proposed to be the percentage of E-cadherin bound to the cytoskeleton/membrane-skeleton), from approximately 60% to 8% (low- and high-calcium mediums, respectively).	Calcium	0-7	cadherin 1	Mus musculus	237-247
7550606-5	1994	DETC also adhered congruent to three-fold better to KC and E-cadherin-transfected fibroblasts than to normal fibroblasts.	DETC	0-4	cadherin 1	Mus musculus	59-69
8983064-1	1994	The invasion-suppressor molecule E-cadherin (E-CAD) can be regulated at multiple levels: synthesis, processing and stability of mRNA; synthesis, processing and stability of protein; localization and posttranslational modification of protein; binding to catenins (E-CAD-associated proteins); and size and charge of cell surface glycosaminoglycans.	Glycosaminoglycans	327-345	cadherin 1	Mus musculus	33-43
8983064-1	1994	The invasion-suppressor molecule E-cadherin (E-CAD) can be regulated at multiple levels: synthesis, processing and stability of mRNA; synthesis, processing and stability of protein; localization and posttranslational modification of protein; binding to catenins (E-CAD-associated proteins); and size and charge of cell surface glycosaminoglycans.	Glycosaminoglycans	327-345	cadherin 1	Mus musculus	45-50
8106878-4	1993	This study aimed to determine whether the calcium-dependent, cell adhesion molecule, E-cadherin was appropriately placed both temporally and spatially to contribute to the formation and maintenance of the reticular lamina.	Calcium	42-49	cadherin 1	Mus musculus	85-95
8298032-7	1993	Calcium-induced differentiation decreases the sum of the percentages of molecules in the directed diffusion and the stationary modes outside of the cell-cell contact regions on the cell surface (which is proposed to be the percentage of E-cadherin bound to the cytoskeleton/membrane-skeleton), from approximately 60% to 8% (low- and high-calcium mediums, respectively).	Calcium	338-345	cadherin 1	Mus musculus	237-247
8224605-4	1993	The review first discusses the critical role of cell-cell interactions in fertilization and early lineage decisions that occur during pre- and peri-implantation development in the mouse, using the calcium-dependent cell adhesion molecule E-cadherin as the primary example.	Calcium	197-204	cadherin 1	Mus musculus	238-248
8081831-6	1993	When compact 8-cell embryos were decompacted in calcium-free medium, uvomorulin at contacts decreased while free surface and cytoplasmic staining increased.	Calcium	48-55	cadherin 1	Mus musculus	69-79
34859959-9	2022	Pancreas isolated from KC mice fed with an ethanol-containing diet show higher expression of stem cell markers (CD133, CD44, CD24), pluripotency-maintaining factors (cMyc, KLF4, SOX-2, and Oct-4), N-Cadherin, EMT-transcription factors (Snail, Slug, and Zeb1), and lower expression of E-cadherin than those isolated from mice fed with a control diet.	Ethanol	43-50	cadherin 1	Mus musculus	284-294
2182648-1	1990	The liver cell adhesion molecule (L-CAM) and N-cadherin or adherens junction-specific CAM (A-CAM) are structurally related cell surface glycoproteins that mediate calcium-dependent adhesion in different tissues.	Calcium	163-170	cadherin 1	Mus musculus	4-32
2182648-1	1990	The liver cell adhesion molecule (L-CAM) and N-cadherin or adherens junction-specific CAM (A-CAM) are structurally related cell surface glycoproteins that mediate calcium-dependent adhesion in different tissues.	Calcium	163-170	cadherin 1	Mus musculus	34-39
33773208-10	2021	Treatment with either IC87114 or AMG319 not only attenuated LPS-induced edema, lung injury and neutrophilc inflammation, reduced total protein concentration and IL-6, TNF-alpha secretion in BALF, but also restored epithelial E-cadherin and claudin-2 expression.	IC 87114	22-29	cadherin 1	Mus musculus	225-235
33773208-10	2021	Treatment with either IC87114 or AMG319 not only attenuated LPS-induced edema, lung injury and neutrophilc inflammation, reduced total protein concentration and IL-6, TNF-alpha secretion in BALF, but also restored epithelial E-cadherin and claudin-2 expression.	N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine	33-39	cadherin 1	Mus musculus	225-235
34859959-6	2022	Ethanol treatment of HPNE cells results in downregulation of E-Cadherin and upregulation of N-Cadherin, Snail, Slug, Zeb1, Nanog and BMI-1.	Ethanol	0-7	cadherin 1	Mus musculus	61-71
1650371-2	1991	In several mouse epidermal cell lines, we found a good correlation between the level of GJIC and that of immunohistochemical staining of E-cadherin, a calcium-dependent cell adhesion molecule, at cell-cell contact areas.	Calcium	151-158	cadherin 1	Mus musculus	137-147
1650371-6	1991	All transfectants expressed E-cadherin molecules at cell-cell contact areas in a calcium-dependent manner.	Calcium	81-88	cadherin 1	Mus musculus	28-38
1650371-8	1991	These results suggest that Ca(2+)-dependent regulation of GJIC in mouse epidermal cells is directly controlled by a calcium-dependent cell adhesion molecule, E-cadherin.	Calcium	116-123	cadherin 1	Mus musculus	158-168
2218942-6	1990	The possibility that two of the proteins which exhibit a shift in pI following MNU exposure represent the cell adhesion molecules, N-CAM and L-CAM (based on similar Mr values), was investigated by Western blot analysis.	Methylnitrosourea	79-82	cadherin 1	Mus musculus	141-146
34556494-3	2022	In vivo and in vitro studies have identified gene expression changes following iloprost treatment, including increased E-cadherin and PPARgamma and decreased COX2 and Vimentin.	Iloprost	79-87	cadherin 1	Mus musculus	119-129
34801529-5	2021	Moreover, Farrerol up-regulated Cyt C (in the cytoplasm), Cleaved caspase-3/9 and E-cadherin levels, but down-regulated Cyclin D1, N-cadherin and Vimentin levels in LSCC cells.	farrerol	10-18	cadherin 1	Mus musculus	82-92
34864627-10	2022	Moreover, we observed that RA induced G1/S cell cycle arrest and apoptosis in the PDAC cells through regulating the expression of P21, P27, CDK2, Cyclin E, Bax, and Bcl-2, it inhibited the PDAC cell migration and invasion via E-cadherin and MMP-9.	rosmarinic acid	27-29	cadherin 1	Mus musculus	226-236
34864817-7	2021	DHT treatment decreased epithelial expression of E-cadherin and beta-catenin but increased the expression of the mesenchymal marker proteins Vimentin and N-cadherin.	Dihydrotestosterone	0-3	cadherin 1	Mus musculus	49-59
34934771-5	2021	Our data showed that ginsenoside CK effectively prevented TGF-beta-induced EMT, as indicated by the upregulation of E-cadherin and downregulation of vimentin.	ginsenoside M1	21-35	cadherin 1	Mus musculus	116-126
34357837-7	2021	RESULTS: In vivo, curcumin reduced the size of the prostate, suppressed the expression of vimentin and TLR4, and increased the expression of E-cadherin and BAMBI in the LPS-induced BPH mouse model.	Curcumin	18-26	cadherin 1	Mus musculus	141-151
34710830-0	2021	Modulation of E-Cadherin and N-Cadherin by ovarian steroids and embryonic stimuli.	Steroids	51-59	cadherin 1	Mus musculus	14-24
34620548-10	2021	Moreover, both TP and TP-nanolip-PEG suppressed the polarization of M2 macrophages and downregulated gene expressions of TGF-beta1, Smad 2, Smad 3, alpha-SMA, and collagen I (p < 0.05), but upregulated the gene expression of E-cadherin (p < 0.05), thus reversing TGF-beta1 induced EMT/EndoMT and attenuating subretinal fibrosis.	triptolide	15-17	cadherin 1	Mus musculus	225-235
34620548-10	2021	Moreover, both TP and TP-nanolip-PEG suppressed the polarization of M2 macrophages and downregulated gene expressions of TGF-beta1, Smad 2, Smad 3, alpha-SMA, and collagen I (p < 0.05), but upregulated the gene expression of E-cadherin (p < 0.05), thus reversing TGF-beta1 induced EMT/EndoMT and attenuating subretinal fibrosis.	triptolide	22-24	cadherin 1	Mus musculus	225-235
34710830-3	2021	In the present study, we investigated the expression of E-Cad and N-Cad in the mouse endometrial luminal epithelium and its modulation by estrogen, progesterone, and embryonic stimuli.	Phenobarbital	97-104	cadherin 1	Mus musculus	56-61
34710830-3	2021	In the present study, we investigated the expression of E-Cad and N-Cad in the mouse endometrial luminal epithelium and its modulation by estrogen, progesterone, and embryonic stimuli.	Progesterone	148-160	cadherin 1	Mus musculus	56-61
34710830-4	2021	We observed that E-Cad is diffusely expressed in the luminal epithelium of mouse endometrium during the estrus stage and upon estrogen treatment.	Phenobarbital	53-60	cadherin 1	Mus musculus	17-22
34681813-7	2021	Utilization of an in vivo lung injury model by treating bleomycin on mice followed by ATL treatment to demonstrate the therapeutic effectiveness, such as, less collagen deposition and lower E-cadherin expression.	Bleomycin	56-65	cadherin 1	Mus musculus	190-200
34887935-7	2021	Immunohistochemical (IHC) and western blot (WB) assay were used to detect the expression level of E-cadherin, N-cadherin, vimentin, and TWIST1 to evaluate the effect of QFG on tumor cell EMT progression.	qfg	169-172	cadherin 1	Mus musculus	98-108
34887935-11	2021	In addition, QFG treatment inhibited EMT and induced autophagy progression in CRC tumor cells, including that QFG upregulated the expression of E-cadherin, beclin-1, and LC3-II, but downregulated the expression of N-cadherin, vimentin, TWIST1, and p62.	qfg	13-16	cadherin 1	Mus musculus	144-154
34887935-11	2021	In addition, QFG treatment inhibited EMT and induced autophagy progression in CRC tumor cells, including that QFG upregulated the expression of E-cadherin, beclin-1, and LC3-II, but downregulated the expression of N-cadherin, vimentin, TWIST1, and p62.	qfg	110-113	cadherin 1	Mus musculus	144-154
34499199-5	2021	Although the combination of doxorubicin and SB431542 did not exhibit synergism in the inhibition of cell growth and apoptosis induction, it efficiently prohibited the migration and the epithelial to mesenchymal transition of B16-F10 cells, and the combination of doxorubicin and SB431542 caused an increase in mRNA levels of E-cadherin and, on the other hand, led to a decline in the expression of Vimentin.	Doxorubicin	28-39	cadherin 1	Mus musculus	325-335
34499199-5	2021	Although the combination of doxorubicin and SB431542 did not exhibit synergism in the inhibition of cell growth and apoptosis induction, it efficiently prohibited the migration and the epithelial to mesenchymal transition of B16-F10 cells, and the combination of doxorubicin and SB431542 caused an increase in mRNA levels of E-cadherin and, on the other hand, led to a decline in the expression of Vimentin.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	44-52	cadherin 1	Mus musculus	325-335
34499199-5	2021	Although the combination of doxorubicin and SB431542 did not exhibit synergism in the inhibition of cell growth and apoptosis induction, it efficiently prohibited the migration and the epithelial to mesenchymal transition of B16-F10 cells, and the combination of doxorubicin and SB431542 caused an increase in mRNA levels of E-cadherin and, on the other hand, led to a decline in the expression of Vimentin.	Doxorubicin	263-274	cadherin 1	Mus musculus	325-335
34499199-5	2021	Although the combination of doxorubicin and SB431542 did not exhibit synergism in the inhibition of cell growth and apoptosis induction, it efficiently prohibited the migration and the epithelial to mesenchymal transition of B16-F10 cells, and the combination of doxorubicin and SB431542 caused an increase in mRNA levels of E-cadherin and, on the other hand, led to a decline in the expression of Vimentin.	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	279-287	cadherin 1	Mus musculus	325-335
34884634-6	2021	Likewise, ethanol upregulates several inflammatory genes (IL-1beta, iNOS, TNF-alpha) and miRNAs (miR-155-5p, miR-146a-5p) and alters structural and permeability genes (INTL1, CDH1, CFTR) in the colon of WT mice.	Ethanol	10-17	cadherin 1	Mus musculus	175-179
34659889-6	2021	In vitro assays suggested that matrine partially blocked the metastasis of LLCs, and inhibited EMT induced by M2-like macrophages, which was evidenced by up-regulating the expression of E-cadherin and down-regulating the expression of N-cadherin, vimentin, and Snail.	matrine	31-38	cadherin 1	Mus musculus	186-196
34399201-7	2021	Treating renal epithelial cells with CAEA in TGF-beta exposed cell culture successfully maintained the content of E-cadherin and inhibited the expression of mesenchymal marker, indicating that CAEA prevented renal epithelial cells undergo EMT after TGF-beta exposure.	caea	37-41	cadherin 1	Mus musculus	114-124
34399201-9	2021	CAEA can protect against I/R-induced renal remodeling by inhibiting inflammatory reactions and consecutively inhibiting TGF-beta-induced EMT, characterized by the preserved E-cadherin expression and alleviated alpha-SMA and collagen expression, as well as the alleviated of renal fibrosis.	caea	0-4	cadherin 1	Mus musculus	173-183
34168289-11	2021	A8301 administration increased the expression of E-cadherin and reduced the expression of vimentin.	a8301	0-5	cadherin 1	Mus musculus	49-59
34111662-11	2021	Moreover, it confirmed that inhibition of ROS recovered the expression levels of E-cadherin, Occludin and ZO-1, and ameliorated inflammation and mucus secretion in airway in OVA-induced mice exposed to PM2.5.	Reactive Oxygen Species	42-45	cadherin 1	Mus musculus	81-91
34168289-5	2021	VPA (1 mM) was applied prior to the administration of TGF-beta1 and the expression of E-cadherin, vimentin, p-Smad2/3 and p-Akt was assessed.	Valproic Acid	0-3	cadherin 1	Mus musculus	86-96
34344445-15	2021	Expression of markers of epithelial-mesenchymal transition (Cdh1, Cdh3) and the induction of EMT regulators (Zeb1, Zeb2, Gli3, Snai1, and Ptch2) were significantly responsive to progesterone.	Progesterone	178-190	cadherin 1	Mus musculus	60-64
34414236-7	2021	BE-BJO treatment improved the morphology of colon tissue, inhibited the production and release of TNF-alpha, IFN-gamma, IL-6, and IL-1beta in the colon tissue, and reversed the decreased expressions of ZO-1, occludin, claudin-1, and E-cadherin induced by DSS but augmented claudin-2 expression.	be-bjo	0-6	cadherin 1	Mus musculus	233-243
34128029-6	2021	Simultaneously, a CY-induced decrease in the ratio of villi length/crypt depth and the number of intraepithelial lymphocytes and goblet cells was reversed by AH treatment, as were the alterations in the expression of ZO-1, mucin-2, E-cadherin and occludin in the intestine and the concentrations of SCFAs in the colon.	Cyclophosphamide	18-20	cadherin 1	Mus musculus	232-242
34128029-6	2021	Simultaneously, a CY-induced decrease in the ratio of villi length/crypt depth and the number of intraepithelial lymphocytes and goblet cells was reversed by AH treatment, as were the alterations in the expression of ZO-1, mucin-2, E-cadherin and occludin in the intestine and the concentrations of SCFAs in the colon.	ah	158-160	cadherin 1	Mus musculus	232-242
34364922-6	2021	We determined the expression level of epithelia cadherin (E-cadherin) and alpha-smooth muscle actin (alpha-SMA) in the lungs and A549 cells after PQ exposure.	Paraquat	146-148	cadherin 1	Mus musculus	48-56
34364922-6	2021	We determined the expression level of epithelia cadherin (E-cadherin) and alpha-smooth muscle actin (alpha-SMA) in the lungs and A549 cells after PQ exposure.	Paraquat	146-148	cadherin 1	Mus musculus	58-68
34422811-7	2021	Results: Overexpression of lncRNA TPA decreased the expression of E-cadherin, and significantly increased the expression of Vimentin, fibronectin and TGF-beta1 (p < 0.01), and increased the migration rate, migration ability and invasion ability of cell group (P < 0.01).	Tetradecanoylphorbol Acetate	34-37	cadherin 1	Mus musculus	66-76
34272284-5	2021	However, reducing preexisting coordination in the tissue by specifically inhibiting E-cadherin-dependent cell-cell adhesion, either by disrupting the formation of cell-cell junctions with E-cadherin-specific antibodies or rapidly dismantling E-cadherin junctions with calcium chelators, significantly improved controllability.	Calcium	268-275	cadherin 1	Mus musculus	242-252
34267342-9	2022	Furthermore, we revealed that bergenin inhibited glutaminolysis by regulating the level of CDK1, phosphorylation and degradation of Cdh1, and APC/C-Cdh1-mediated ubiquitin-proteasomal degradation of GLS1 after activating PPARgamma.	bergenin	30-38	cadherin 1	Mus musculus	148-152
34308856-8	2021	AZD2014 treatment inhibited tumor cell proliferation, angiogenesis and EMT progression as shown by decreased expressions of Ki-67, CD31, N-cadherin, and vimentin and increased expression of E-cadherin in the tumor tissue, and significantly promoted tumor cell apoptosis as shown by an increased expression of cleaved caspase-3 in AZD2014-treated mice.	vistusertib	0-7	cadherin 1	Mus musculus	190-200
34267342-9	2022	Furthermore, we revealed that bergenin inhibited glutaminolysis by regulating the level of CDK1, phosphorylation and degradation of Cdh1, and APC/C-Cdh1-mediated ubiquitin-proteasomal degradation of GLS1 after activating PPARgamma.	bergenin	30-38	cadherin 1	Mus musculus	132-136
34267342-10	2022	We demonstrated a correlation existing among bergenin-affected GLS1-dependent glutaminolysis, PPARgamma, "CDK1-APC/C-Cdh1" signaling, and Th17 differentiation.	bergenin	45-53	cadherin 1	Mus musculus	117-121
34267342-12	2022	In conclusion, bergenin repressed Th17 differentiation and then alleviated neutrophilic asthma in mice by inhibiting GLS1-dependent glutaminolysis via regulating the "CDK1-APC/C-Cdh1" signaling after activating PPARgamma.	bergenin	15-23	cadherin 1	Mus musculus	178-182
35349832-9	2022	Moreover, capsaicin treatment dramatically protected against the phenotypic alteration of tubular epithelial cells by increasing E-cadherin expression and decreasing vimentin expression during renal fibrosis.	Capsaicin	10-19	cadherin 1	Mus musculus	129-139
34127806-6	2021	The preclinical study using the in vivo mouse model confirms in vitro cell lines data, showing that Enz treatment could increase PCa metastasis, which can be suppressed after suppressing circRNA-ARC1 with sh-circRNA-ARC1.	enzalutamide	100-103	cadherin 1	Mus musculus	195-199
34127806-6	2021	The preclinical study using the in vivo mouse model confirms in vitro cell lines data, showing that Enz treatment could increase PCa metastasis, which can be suppressed after suppressing circRNA-ARC1 with sh-circRNA-ARC1.	enzalutamide	100-103	cadherin 1	Mus musculus	216-220
34064322-8	2021	NuF otherwise increased epithelial-like marker E-cadherin expression and induce NO-mediated intrinsic apoptotic pathway in tumor cells, thereby strengthening the ability of the targeted therapy drug Iressa for inhibiting tumor progression.	Gefitinib	199-205	cadherin 1	Mus musculus	47-57
34257820-4	2021	Lower E-cadherin expression is related to a higher level of KDM6A, while E-cadherin is promoted upon treatment with the KDM6A inhibitor GSK-J4 in both high glucose- (HG-) induced HK2 cells and the kidneys from streptozotocin- (STZ-) induced type 1 diabetic mice.	Streptozocin	210-224	cadherin 1	Mus musculus	73-83
34257820-4	2021	Lower E-cadherin expression is related to a higher level of KDM6A, while E-cadherin is promoted upon treatment with the KDM6A inhibitor GSK-J4 in both high glucose- (HG-) induced HK2 cells and the kidneys from streptozotocin- (STZ-) induced type 1 diabetic mice.	Streptozocin	227-230	cadherin 1	Mus musculus	73-83
35349832-10	2022	Mechanistically, capsaicin treatment effectively suppressed alpha-SMA and vimentin expressions but promoted E-cadherin expression in HK2 cells mainly through the inhibition of TGF-beta1-Smad2/3 signaling.	Capsaicin	17-26	cadherin 1	Mus musculus	108-118
35184686-9	2022	MiR-144-5p overexpression and PTX further up-regulated E-cadherin level and down-regulated those of MMP-9 and N-cadherin in thyroid carcinoma cells.	Paclitaxel	30-33	cadherin 1	Mus musculus	55-65
35406381-6	2022	Treatment of isogenic human cells and mouse gastric and mammary organoids with dasatinib, a small molecule inhibitor of multiple kinases including SRC, BCR-ABL and DDR2, preferentially slowed the growth and induced apoptosis of E-cadherin-deficient cells.	Dasatinib	79-88	cadherin 1	Mus musculus	228-238
35471977-11	2022	Anlotinib treatment reduced PCNA, CDK1, and MMP2 protein expressions and increased E-cadherin protein expression in gastric cancer cells (p < 0.01).	anlotinib	0-9	cadherin 1	Mus musculus	83-93
35509835-7	2022	Results: PTUPB treatment reversed the increase of mesenchymal marker molecule alpha-smooth muscle actin (alpha-SMA) and the loss of epithelial marker molecule E-cadherin in lung tissue of PF mice.	PTUPB	9-14	cadherin 1	Mus musculus	159-169
35074512-9	2022	In vitro experiments demonstrated that LPA upregulated the expression of E-cadherin, ZO-1, and filamentous actin (F-actin) at the cellular membrane, whereas LPA6 knockdown decreased their expression and changed cell morphology.	lysophosphatidic acid	39-42	cadherin 1	Mus musculus	73-83
35093635-5	2022	The organoids in the DMSO-treated groups as well as the control, expressed ChrgA, Ecad, Muc2, Lyz, villin, and Lgr5, and there are no significant.	Dimethyl Sulfoxide	21-25	cadherin 1	Mus musculus	82-86
35154426-4	2022	In addition, emodin inhibited the migration and invasion abilities of the ovarian cancer cells by inhibiting epithelial-mesenchymal transition (EMT), which was evidenced by the downregulation of N-cadherin and vimentin, and the upregulation of E-cadherin protein expression levels.	Emodin	13-19	cadherin 1	Mus musculus	244-254
35186676-8	2022	The expression of E-cadherin in the local RPE cells decreased, while alpha-SMA increased significantly in subretinal fibrosis lesions, and the application of anti-PGF neutralizing antibody could reverse these changes (P<0.05).	Prostaglandins F	163-166	cadherin 1	Mus musculus	18-28
35038315-7	2022	PA treated embryos had lower expression of blastocyst formation proteins (E-cadherin, ZO-1 and Na/K-ATPase alpha1 subunit).	Palmitic Acid	0-2	cadherin 1	Mus musculus	74-84
34735003-0	2022	N6-methyladenosine modification of CDH1 mRNA promotes PM2.5-induced pulmonary fibrosis via mediating epithelial mesenchymal transition.	N-methyladenosine	0-18	cadherin 1	Mus musculus	35-39
35148729-13	2022	In addition, JNJ-26482585 and romidepsin ameliorated the redistribution of E-cadherin and beta-catenin in TDI-induced asthma.	romidepsin	30-40	cadherin 1	Mus musculus	75-85
35356877-4	2022	Results DEK protein was highly expressed in the lung tissues of OVA group mice and decreased in the DTA-64 group mice; DTA-64 reduced the infiltration of eosinophils and neutrophils around the airways, down-regulated serum OVA-specific IgE and IL-4, IL-5, IL-13 in BALF, and up-regulated IFN-gamma; DTA-64 also reduced the expressions of vimentin, alpha-SMA, Snail+Slug in the lung tissue, and up-regulated epithelial marker E-cadherin.	deoxythymidylyl-3'-5'-deoxyadenylate	119-122	cadherin 1	Mus musculus	425-435
33852061-11	2021	E-cadherin and ZO-1 levels in airway tissues of asthmatic mice were significantly lower than that of control mice, and the reduction was recovered by H2 treatment.	Deuterium	150-152	cadherin 1	Mus musculus	0-10
33721755-4	2021	Mechanistically, the exogenous leukotrienes B4 and C4, the downstream products of 5-LO, could induce the epithelial-mesenchymal transition (EMT) in kidney epithelial cell cultures, based on assays of E-cadherin, vimentin and snail expression.	Leukotrienes	31-43	cadherin 1	Mus musculus	200-210
33984142-12	2021	In vivo, anti-meningioma effect of Erastin was augmented by MEF2C knockdown and was counteracted by NF2 or E-Cadherin.	erastin	35-42	cadherin 1	Mus musculus	107-117
2780560-2	1989	To examine the influence of CAM expression on such cell segregation events in vitro, we have transfected cells with cDNAs coding for two calcium-dependent CAMs of different specificity, the liver CAM (L-CAM) and the structurally related molecule N-cadherin.	Calcium	137-144	cadherin 1	Mus musculus	155-158
2897121-5	1988	In situ hybridization of uvomorulin [3H]cDNA to mouse metaphase chromosomes located the Um locus close to the distal end of chromosome 8 (bands C3-E1).	Tritium	37-39	cadherin 1	Mus musculus	25-35
33345606-5	2021	Besides, CS-exposed mice with chrysene treatment showed obvious collagen deposition, elevated alpha-smooth muscle actin (alpha-SMA) expression and reduced E-cadherin abundance at earlier stage, which suggested the acceleration and aggravation of pulmonary fibrosis.	Cesium	9-11	cadherin 1	Mus musculus	155-165
33345606-5	2021	Besides, CS-exposed mice with chrysene treatment showed obvious collagen deposition, elevated alpha-smooth muscle actin (alpha-SMA) expression and reduced E-cadherin abundance at earlier stage, which suggested the acceleration and aggravation of pulmonary fibrosis.	chrysene	30-38	cadherin 1	Mus musculus	155-165
33688971-0	2021	Effect of irradiation on the expression of E-cadherin and beta-catenin in early and late radiation sequelae of the urinary bladder and its modulation by NF-kappaB inhibitor thalidomide.	Thalidomide	173-184	cadherin 1	Mus musculus	43-53
33990686-4	2021	Blocking GPR35 function in CECs using the GPR35 antagonist ML145, in conjunction with shRNA knock-down and CRISPRcas-mediated knock-out, resulted in reduced CEC-response to BFT as measured by E-cadherin cleavage, beta-arrestin recruitment and IL-8 secretion.	2-hydroxy-4-(4-(5-(2-methyl-3-phenylprop-2-enylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)butanoylamino)benzoic acid	59-64	cadherin 1	Mus musculus	192-202
33984142-8	2021	Meningioma cells grown at higher density increased expression of E-Cadherin, which suppressed Erastin-induced ferroptosis.	erastin	94-101	cadherin 1	Mus musculus	65-75
33554651-4	2021	High glucose-induced degradation and endocytosis of E-cadherin of corneal epithelial cells reduce the formation of beta-catenin/E-cadherin complex and promote the nuclear translocation of beta-catenin.	Glucose	5-12	cadherin 1	Mus musculus	52-62
33554651-4	2021	High glucose-induced degradation and endocytosis of E-cadherin of corneal epithelial cells reduce the formation of beta-catenin/E-cadherin complex and promote the nuclear translocation of beta-catenin.	Glucose	5-12	cadherin 1	Mus musculus	128-138
32812524-10	2021	The in vitro experiment showed that 1,25(OH)2D3 alleviated TGF-beta1-mediated downregulation of E-cadherin and inhibited TGF-beta1-evoked upregulation of N-cadherin, vimentin and alpha-SMA in renal epithelial HK-2 cells.	methyl 5-methyl-3-(1,2-oxazol-5-yl)-1H-pyrazole-4-carboxylate	44-47	cadherin 1	Mus musculus	96-106
33865946-5	2021	However, DNA methylation profiling in cell-cycle-related genes, such as Cdkn2a, Dapk1, Cdh1, Mlh1, Timp3, and Rarb, decreased in imidacloprid treatments, suggesting the potential influence of DNA methylation patterns on cell differentiation.	imidacloprid	129-141	cadherin 1	Mus musculus	87-91