PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 34058788-6 2021 However, binding of a human soluble SIRPalpha -Fc fusion protein to SEN177 treated cancer cells was significantly reduced in a dose-dependent manner, suggesting that pyro-glutamate formation of CD47 was affected. Pyrrolidonecarboxylic Acid 166-180 CD47 molecule Homo sapiens 194-198 33930347-0 2021 Berberine exerts anti-tumor activity in diffuse large B-cell lymphoma by modulating c-myc/CD47 axis. Berberine 0-9 CD47 molecule Homo sapiens 90-94 33930347-3 2021 Here, we validated berberine, a natural compound, as a suppressor of CD47 and revealed the involved mechanism and biological function in DLBCL. Berberine 19-28 CD47 molecule Homo sapiens 69-73 33930347-4 2021 Berberine downregulated the expression of CD47 in DLBCL at the transcriptional level by suppressing c-myc expression. Berberine 0-9 CD47 molecule Homo sapiens 42-46 33930347-5 2021 Berberine-induced CD47 inhibition enhanced the phagocytosis of macrophages, thereby eliminating DLBCL cells in vitro and in vivo. Berberine 0-9 CD47 molecule Homo sapiens 18-22 33930347-6 2021 Interestingly, berberine enhanced the efficiency of anti-CD47 antibody and rituximab-mediated phagocytosis. Berberine 15-24 CD47 molecule Homo sapiens 57-61 33930347-8 2021 Our results highlighted for the first time that berberine could restore macrophage function in the tumor microenvironment, enhance rituximab-mediated phagocytosis and promote anti-CD47 antibody function via suppressing CD47 expression, which revealed a new anti-tumor mechanism of berberine and provided novel insights into the rituximab-based immunochemotherapy and CD47-targeted immunotherapy in DLBCL. Berberine 48-57 CD47 molecule Homo sapiens 180-184 33930347-8 2021 Our results highlighted for the first time that berberine could restore macrophage function in the tumor microenvironment, enhance rituximab-mediated phagocytosis and promote anti-CD47 antibody function via suppressing CD47 expression, which revealed a new anti-tumor mechanism of berberine and provided novel insights into the rituximab-based immunochemotherapy and CD47-targeted immunotherapy in DLBCL. Berberine 48-57 CD47 molecule Homo sapiens 219-223 33930347-8 2021 Our results highlighted for the first time that berberine could restore macrophage function in the tumor microenvironment, enhance rituximab-mediated phagocytosis and promote anti-CD47 antibody function via suppressing CD47 expression, which revealed a new anti-tumor mechanism of berberine and provided novel insights into the rituximab-based immunochemotherapy and CD47-targeted immunotherapy in DLBCL. Berberine 48-57 CD47 molecule Homo sapiens 219-223 34051623-1 2021 "Don"t eat me" signal of CD47 is activated via its interaction with SIRPalpha protein on myeloid cells, especially phagocytic cells, and prevents malignant cells from anti-tumor immunity in which pyroglutamate modification of CD47 by glutaminyl-peptide cyclotransferase-like protein (isoQC) takes an important part evidenced by our previous report that isoQC is an essential regulator for CD47-SIRPalpha axis with a strong inhibition on macrophage-mediated phagoctyosis. Pyrrolidonecarboxylic Acid 196-209 CD47 molecule Homo sapiens 25-29 34051623-1 2021 "Don"t eat me" signal of CD47 is activated via its interaction with SIRPalpha protein on myeloid cells, especially phagocytic cells, and prevents malignant cells from anti-tumor immunity in which pyroglutamate modification of CD47 by glutaminyl-peptide cyclotransferase-like protein (isoQC) takes an important part evidenced by our previous report that isoQC is an essential regulator for CD47-SIRPalpha axis with a strong inhibition on macrophage-mediated phagoctyosis. Pyrrolidonecarboxylic Acid 196-209 CD47 molecule Homo sapiens 226-230 34051623-1 2021 "Don"t eat me" signal of CD47 is activated via its interaction with SIRPalpha protein on myeloid cells, especially phagocytic cells, and prevents malignant cells from anti-tumor immunity in which pyroglutamate modification of CD47 by glutaminyl-peptide cyclotransferase-like protein (isoQC) takes an important part evidenced by our previous report that isoQC is an essential regulator for CD47-SIRPalpha axis with a strong inhibition on macrophage-mediated phagoctyosis. Pyrrolidonecarboxylic Acid 196-209 CD47 molecule Homo sapiens 226-230 34016744-7 2021 Inhibition of exosome secretion with GW4869 and exosome uptake with EIPA inhibited the surface CD47 expression on OC cells and promoted phagocytosis by macrophages. ethylisopropylamiloride 68-72 CD47 molecule Homo sapiens 95-99 34020945-6 2021 We show that Zeb1 links these two resistance pathways because it is required for PDL1 expression on invading lung cancer cells, and it also induces CD47 on these invading cells, which drives M2 polarization of adjacent TAMs. tams 219-223 CD47 molecule Homo sapiens 148-152 33988261-3 2021 Here, we show that polyinosinic-polycytidylic acid (Poly(I:C)), a synthetic analog of double-stranded RNA, enhances the antitumor activity of CD47 blockade in colorectal cancer in vitro and in vivo. Poly I-C 19-50 CD47 molecule Homo sapiens 142-146 33999416-0 2021 Anti-CD47 Antibody Synergizes with Cisplatin Against Laryngeal Cancer by Enhancing Phagocytic Ability of Macrophages. Cisplatin 35-44 CD47 molecule Homo sapiens 5-9 33999416-5 2021 Cluster of Differentiation (CD47) was selected for its high expression in Cisplatin-treated laryngeal cancer cells. Cisplatin 74-83 CD47 molecule Homo sapiens 28-32 33999416-6 2021 Blocking CD47 expression using its neutralizing antibody (aCD47) synergized with Cisplatin to increase macrophage phagocytosis in a co-culture system of human epithelial type 2 (Hep-2) cancer cells with tumor-associated macrophages (TAMs). Cisplatin 81-90 CD47 molecule Homo sapiens 9-13 33988261-3 2021 Here, we show that polyinosinic-polycytidylic acid (Poly(I:C)), a synthetic analog of double-stranded RNA, enhances the antitumor activity of CD47 blockade in colorectal cancer in vitro and in vivo. Poly I-C 52-61 CD47 molecule Homo sapiens 142-146 33988261-6 2021 Our findings demonstrate the potential of Poly(I:C) to synergize the efficacy of CD47 blockade therapy and a novel role for IL-6 in macrophage phagocytosis, which provide new strategy for combinational cancer immunotherapy. Poly I-C 42-51 CD47 molecule Homo sapiens 81-85 33936211-7 2021 Furthermore, autophagy flux following treatment with an autophagy inducer, rapamycin, has shown that CD47 is a key player in autophagy and senescence to maintain and regulate the growth of MSCs, suggesting that CD47 may be a critical key marker for the selection of effective stem cells in cell therapy. Sirolimus 75-84 CD47 molecule Homo sapiens 101-105 33936211-7 2021 Furthermore, autophagy flux following treatment with an autophagy inducer, rapamycin, has shown that CD47 is a key player in autophagy and senescence to maintain and regulate the growth of MSCs, suggesting that CD47 may be a critical key marker for the selection of effective stem cells in cell therapy. Sirolimus 75-84 CD47 molecule Homo sapiens 211-215 33788151-10 2021 Besides, various immune checkpoint proteins expressed on the surface of TAMs, such as PD-1 and CD47, provide the possibility of the application of immune checkpoint inhibitors. tams 72-76 CD47 molecule Homo sapiens 95-99 33753567-0 2021 Effect of cabazitaxel on macrophages improves CD47-targeted immunotherapy for triple-negative breast cancer. cabazitaxel 10-21 CD47 molecule Homo sapiens 46-50 33742767-0 2022 Exploratory window-of-opportunity trial to investigate the tumor pharmacokinetcs/pharmacodynamics of the IAP antagonist Debio 1143 in patients with head and neck cancer. N-benzhydryl-5-(2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo(1,2-a)(1,5)diazocine-8-carboxamide 120-130 CD47 molecule Homo sapiens 105-108 33742767-2 2022 The orally available IAP antagonist Debio 1143 has potential to enhance tumor response to chemoradiotherapy and/or immunotherapy. N-benzhydryl-5-(2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo(1,2-a)(1,5)diazocine-8-carboxamide 36-46 CD47 molecule Homo sapiens 21-24 33389016-6 2021 RESULTS: Gastric cancer patients with high CD47 expression exhibited poor prognosis and inferior therapeutic responsiveness to fluorouracil-based adjuvant chemotherapy (ACT). Fluorouracil 127-139 CD47 molecule Homo sapiens 43-47 32761423-4 2021 To overcome these limitations and further improve therapeutic efficacy, we designed IBI322, a CD47/PD-L1 bispecific antibody which attenuated CD47 activity in monovalent binding and blocked PD-L1 activity in bivalent binding. ibi322 84-90 CD47 molecule Homo sapiens 94-98 32761423-4 2021 To overcome these limitations and further improve therapeutic efficacy, we designed IBI322, a CD47/PD-L1 bispecific antibody which attenuated CD47 activity in monovalent binding and blocked PD-L1 activity in bivalent binding. ibi322 84-90 CD47 molecule Homo sapiens 142-146 32761423-5 2021 IBI322 selectively bound to CD47+PD-L1+ tumor cells, effectively inhibited CD47-SIRPalpha signal and triggered strong tumor cell phagocytosis in vitro, but only with minimal impact on CD47 single positive cells such as human RBCs. ibi322 0-6 CD47 molecule Homo sapiens 28-32 32761423-5 2021 IBI322 selectively bound to CD47+PD-L1+ tumor cells, effectively inhibited CD47-SIRPalpha signal and triggered strong tumor cell phagocytosis in vitro, but only with minimal impact on CD47 single positive cells such as human RBCs. ibi322 0-6 CD47 molecule Homo sapiens 75-79 32761423-5 2021 IBI322 selectively bound to CD47+PD-L1+ tumor cells, effectively inhibited CD47-SIRPalpha signal and triggered strong tumor cell phagocytosis in vitro, but only with minimal impact on CD47 single positive cells such as human RBCs. ibi322 0-6 CD47 molecule Homo sapiens 75-79 33552071-11 2020 This is the first study to show that activation of the CD47:SIRPalpha innate immune checkpoint contributes to ADP resistance in NLCs from CLL patients. Adenosine Diphosphate 110-113 CD47 molecule Homo sapiens 55-59 33346187-0 2020 Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization. Metals 45-50 CD47 molecule Homo sapiens 68-72 33365267-0 2020 Thrombospondin-1 Receptor CD47 Overexpression Contributes to P-Glycoprotein-Mediated Multidrug Resistance Against Doxorubicin in Thyroid Carcinoma FTC-133 Cells. Doxorubicin 114-125 CD47 molecule Homo sapiens 26-30 33365267-12 2020 Moreover, knockdown of CD47 in FTC-133R cells induced an increase in JNK activation and sensitized FTC-133R cells to Dox. Doxorubicin 117-120 CD47 molecule Homo sapiens 23-27 33365267-13 2020 Our data suggest that CD47 is able to contribute to the protection of FTC-133R cells against Dox-induced apoptosis and/or to potentiate the acquired Dox resistance. Doxorubicin 93-96 CD47 molecule Homo sapiens 22-26 33365267-13 2020 Our data suggest that CD47 is able to contribute to the protection of FTC-133R cells against Dox-induced apoptosis and/or to potentiate the acquired Dox resistance. Doxorubicin 149-152 CD47 molecule Homo sapiens 22-26 33329583-6 2020 In this review, we will discuss the roles of CD47-SIRPalpha axis in TAMs infiltration and activities and the promising effects of targeting this axis on the activation of both innate and adaptive antitumor immunity in glioblastoma. tams 68-72 CD47 molecule Homo sapiens 45-49 32910689-5 2020 The levels of CD55 and CD47 and the duration of hospitalization were better in the high-dose vitamin E group than in the low-dose vitamin E group. Vitamin E 93-102 CD47 molecule Homo sapiens 23-27 32820530-0 2020 Assessing and mitigating the interference of ALX148, a novel CD47 blocking agent, in pretransfusion compatibility testing. alx148 45-51 CD47 molecule Homo sapiens 61-65 32820530-1 2020 ALX148, a novel CD47 blocking agent, is in clinical development for the treatment of advanced solid tumors and lymphoma. alx148 0-6 CD47 molecule Homo sapiens 16-20 33123143-8 2020 Pre-incubation of NK cells with DHA attenuated NK cell-induced upregulation of CD11b and CD47 on neutrophils, had minor effects on NK cell induction of cytokine/chemokine secretion or their phagocytic ability. Docosahexaenoic Acids 32-35 CD47 molecule Homo sapiens 89-93 32945002-7 2020 Moreover, it is found that the generation of hyperthermia and oxidative stress from Cu2 O@CaCO3 nanocomposites can efficiently reprogram the macrophages from the M2 phenotype to the M1 phenotype and initiate a vaccine-like immune effect after primary tumor removal, which further induces an immune-favorable TME and intense immune responses for anti-CD47 antibody to simultaneously inhibit CRC distant metastasis and recurrence by immunotherapy. cu2 o 84-89 CD47 molecule Homo sapiens 350-354 32945002-7 2020 Moreover, it is found that the generation of hyperthermia and oxidative stress from Cu2 O@CaCO3 nanocomposites can efficiently reprogram the macrophages from the M2 phenotype to the M1 phenotype and initiate a vaccine-like immune effect after primary tumor removal, which further induces an immune-favorable TME and intense immune responses for anti-CD47 antibody to simultaneously inhibit CRC distant metastasis and recurrence by immunotherapy. Calcium Carbonate 90-95 CD47 molecule Homo sapiens 350-354 32808760-13 2020 Loading nMOFs with small-molecule drugs such as an indoleamine 2,3-dioxygenase inhibitor, the toll-like receptor agonist imiquimod, and biomacromolecules such as CpG oligodeoxynucleotides and anti-CD47 antibody synergizes with nMOF-based radical therapies to enhance their immunotherapeutic effects. nmofs 8-13 CD47 molecule Homo sapiens 197-201 32808760-13 2020 Loading nMOFs with small-molecule drugs such as an indoleamine 2,3-dioxygenase inhibitor, the toll-like receptor agonist imiquimod, and biomacromolecules such as CpG oligodeoxynucleotides and anti-CD47 antibody synergizes with nMOF-based radical therapies to enhance their immunotherapeutic effects. n-(2-fluorophenyl)nicotinamide 8-12 CD47 molecule Homo sapiens 197-201 32910689-4 2020 RESULTS: CD55 and CD47 levels in patients taking vitamin E across different nutrition score groups were better than those in patients who did not use vitamin E. Vitamin E 49-58 CD47 molecule Homo sapiens 18-22 32658476-0 2020 Nanoscale Metal-Organic Framework Co-delivers TLR-7 Agonists and Anti-CD47 Antibodies to Modulate Macrophages and Orchestrate Cancer Immunotherapy. Metals 10-15 CD47 molecule Homo sapiens 70-74 32240171-8 2020 We also utilized the LSC assay to confirm published studies showing that the inhibition of amino-terminal pyroglutamate formation on CD47 using the glutaminyl cyclase inhibitor SEN177 disrupts SIRPalpha binding. Pyrrolidonecarboxylic Acid 106-119 CD47 molecule Homo sapiens 133-137 32427583-4 2020 Binding of 1H9 to SIRPalpha blocks its interaction with CD47, thereby promoting macrophage-mediated phagocytosis of cancer cells. 1h9 11-14 CD47 molecule Homo sapiens 56-60 32547698-7 2020 RESULTS: In this study, we discovered that the integrin-associated surface factor CD47 played a critical role in immune defense in the STZ-induced T1D model by preventing pancreatic beta islet inflammation. Streptozocin 135-138 CD47 molecule Homo sapiens 82-86 32547698-10 2020 Moreover, lipopolysaccharide-activated human acute monocytic leukemia THP-1 cells also exhibited enhanced phagocytosis in the STZ-treated islets, and the aggressive attack of the inflammatory islets correlated with impaired CD47-SIRPalpha interactions. Streptozocin 126-129 CD47 molecule Homo sapiens 224-228 32314789-0 2020 Hydrogen gas represses the progression of lung cancer via downregulating CD47. Hydrogen 0-8 CD47 molecule Homo sapiens 73-77 32314789-2 2020 In our previous study, our project group found that H2 could decreased the expression of CD47 in lung cancer A549 cells via using the next generation sequencing, indicating that CD47 might be involved in H2-mediated lung cancer repression. Deuterium 52-54 CD47 molecule Homo sapiens 89-93 32314789-2 2020 In our previous study, our project group found that H2 could decreased the expression of CD47 in lung cancer A549 cells via using the next generation sequencing, indicating that CD47 might be involved in H2-mediated lung cancer repression. Deuterium 52-54 CD47 molecule Homo sapiens 178-182 32314789-2 2020 In our previous study, our project group found that H2 could decreased the expression of CD47 in lung cancer A549 cells via using the next generation sequencing, indicating that CD47 might be involved in H2-mediated lung cancer repression. Deuterium 204-206 CD47 molecule Homo sapiens 89-93 32314789-2 2020 In our previous study, our project group found that H2 could decreased the expression of CD47 in lung cancer A549 cells via using the next generation sequencing, indicating that CD47 might be involved in H2-mediated lung cancer repression. Deuterium 204-206 CD47 molecule Homo sapiens 178-182 32314789-3 2020 Therefore, this study aimed to explore the effects of CD47 on H2-induced lung cancer repression. Deuterium 62-64 CD47 molecule Homo sapiens 54-58 32314789-6 2020 The results showed that H2 treatment caused decreases in the expression levels of CD47 and cell division control protein 42 (CDC42) in a dose-dependent manner. Deuterium 24-26 CD47 molecule Homo sapiens 82-86 32314789-7 2020 Upregulation of CD47 abolished H2 roles in promoting lung cancer cell apoptosis and repressing cell growth, invasion and migration in both A549 and H1975 cell lines. Deuterium 31-33 CD47 molecule Homo sapiens 16-20 32314789-8 2020 However, knockdown of CD47 enhanced H2 role in lung cancer inhibition. Deuterium 36-38 CD47 molecule Homo sapiens 22-26 32314789-10 2020 In conclusion, the current study reveals that H2 inhibits the progression of lung cancer via downregulating CD47, which might be a potent method for lung cancer treatment. Deuterium 46-48 CD47 molecule Homo sapiens 108-112 32450498-0 2020 Studies of combined NO-eluting/CD47-modified polyurethane surfaces for synergistic enhancement of biocompatibility. Polyurethanes 45-57 CD47 molecule Homo sapiens 31-35 32450498-6 2020 In this work, we successfully appended CD47 peptides (pepCD47) to the surface of biomedical grade polyurethane (PU) copolymers. Peptides 44-52 CD47 molecule Homo sapiens 39-43 32450498-6 2020 In this work, we successfully appended CD47 peptides (pepCD47) to the surface of biomedical grade polyurethane (PU) copolymers. polyurethane (pu) copolymers 98-126 CD47 molecule Homo sapiens 39-43 32450498-9 2020 We further constructed a CD47 surface immobilized silicone tubing filled with NO releasing S-nitrosoglutathione/ascorbic acid (GSNO/AA) solution for synergistic biocompatibility evaluation. Silicones 50-58 CD47 molecule Homo sapiens 25-29 32450498-9 2020 We further constructed a CD47 surface immobilized silicone tubing filled with NO releasing S-nitrosoglutathione/ascorbic acid (GSNO/AA) solution for synergistic biocompatibility evaluation. S-Nitrosoglutathione 91-111 CD47 molecule Homo sapiens 25-29 32450498-9 2020 We further constructed a CD47 surface immobilized silicone tubing filled with NO releasing S-nitrosoglutathione/ascorbic acid (GSNO/AA) solution for synergistic biocompatibility evaluation. Ascorbic Acid 112-125 CD47 molecule Homo sapiens 25-29 32450498-9 2020 We further constructed a CD47 surface immobilized silicone tubing filled with NO releasing S-nitrosoglutathione/ascorbic acid (GSNO/AA) solution for synergistic biocompatibility evaluation. S-Nitrosoglutathione 127-131 CD47 molecule Homo sapiens 25-29 31964705-4 2020 Blockade of both macrophages and targets results in hyper-phagocytosis, and knockdown of macrophage-CD47 likewise increases eating of "foreign" cells and particles, decreases SIRPalpha"s baseline inhibitory signaling, and linearly increases binding of soluble-CD47 in trans, consistent with cis-trans competition. cis-parinaric acid methyl ester 291-300 CD47 molecule Homo sapiens 100-104 31801627-0 2019 Functional characterization of the selective pan-allele anti-SIRPalpha antibody ADU-1805 that blocks the SIRPalpha-CD47 innate immune checkpoint. 3'-5'-di-O-(1-adamantyl)-2'-deoxyuridine 80-88 CD47 molecule Homo sapiens 115-119 32082304-0 2019 Enhanced Expression of CD47 Is Associated With Off-Target Resistance to Tyrosine Kinase Inhibitor Gefitinib in NSCLC. Gefitinib 98-107 CD47 molecule Homo sapiens 23-27 31746532-4 2020 Azide-modified exosomes derived from M1 macrophages are conjugated with dibenzocyclooctyne-modified antibodies of CD47 and SIRPalpha (aCD47 and aSIRPalpha) through pH-sensitive linkers. Azides 0-5 CD47 molecule Homo sapiens 114-118 31746532-4 2020 Azide-modified exosomes derived from M1 macrophages are conjugated with dibenzocyclooctyne-modified antibodies of CD47 and SIRPalpha (aCD47 and aSIRPalpha) through pH-sensitive linkers. dibenzocyclooctyne 72-90 CD47 molecule Homo sapiens 114-118 31940587-9 2020 Additionally, VPA and SAHA induced an immunogenic cell death, characterized by the exposure of calreticulin (CALR), as well as decreased the "do not eat me" signal CD47 on tumor cells. Valproic Acid 14-17 CD47 molecule Homo sapiens 164-168 31940587-9 2020 Additionally, VPA and SAHA induced an immunogenic cell death, characterized by the exposure of calreticulin (CALR), as well as decreased the "do not eat me" signal CD47 on tumor cells. vorinostat 22-26 CD47 molecule Homo sapiens 164-168 32275842-2 2020 Herein, positron emission tomography (PET) imaging with 89Zr-labeled IBI322, an anti-CD47/PD-L1 BsAb, was used to optimize the safety and effective therapy dose. ibi322 69-75 CD47 molecule Homo sapiens 85-89 31801627-8 2019 RESULTS: The humanized monoclonal IgG2 antibody ADU-1805 binds to all known human SIRPalpha alleles, showing minimal binding to SIRPbeta1, while cross-reacting with SIRPgamma, and potently blocking the interaction of SIRPalpha with CD47. 3'-5'-di-O-(1-adamantyl)-2'-deoxyuridine 48-56 CD47 molecule Homo sapiens 232-236 31801627-13 2019 CONCLUSIONS: Blocking the SIRPalpha-CD47 interaction via SIRPalpha, while similarly efficacious in vitro, differentiates ADU-1805 from CD47-targeting agents with respect to safety and absence of inhibition of T-cell activation. 3'-5'-di-O-(1-adamantyl)-2'-deoxyuridine 121-129 CD47 molecule Homo sapiens 36-40 30713045-0 2019 The expression of CD47 and its association with 2,3-DPG levels in stored leuco-reduced blood units. 2,3-Diphosphoglycerate 48-55 CD47 molecule Homo sapiens 18-22 31628526-4 2019 Antisense suppression of CD47 on human T cells in vitro using a translational blocking morpholino (CD47 m) alone or combined with anti-CTLA4 enhanced antigen-dependent killing of irradiated melanoma cells. Morpholinos 87-97 CD47 molecule Homo sapiens 25-29 31606701-0 2019 CD47-targeted bismuth selenide nanoparticles actualize improved photothermal therapy by increasing macrophage phagocytosis of cancer cells. Bismuth 14-30 CD47 molecule Homo sapiens 0-4 31606701-2 2019 In this study, we have developed CD47-targeted bismuth selenide nanoparticles (Ab-PEG-Bi2Se3) that increase phagocytosis of cancer cells by macrophages to actualize improved photothermal therapy (PTT). Bismuth 47-63 CD47 molecule Homo sapiens 33-37 31606701-2 2019 In this study, we have developed CD47-targeted bismuth selenide nanoparticles (Ab-PEG-Bi2Se3) that increase phagocytosis of cancer cells by macrophages to actualize improved photothermal therapy (PTT). indium triselenide 82-92 CD47 molecule Homo sapiens 33-37 31628526-4 2019 Antisense suppression of CD47 on human T cells in vitro using a translational blocking morpholino (CD47 m) alone or combined with anti-CTLA4 enhanced antigen-dependent killing of irradiated melanoma cells. Morpholinos 87-97 CD47 molecule Homo sapiens 99-103 30713045-5 2019 The aim of this study was to validate the impact of storage time and leuco-depletion on CD47 expression on the RBCs, which could be a prospective marker for detection of RBCs viability and to clarify if the changes in CD47 expression and 2,3-DPG levels are correlated during storage of Packed RBCs. 2,3-Diphosphoglycerate 238-245 CD47 molecule Homo sapiens 88-92 31632920-8 2019 Re-expressing SLFN11 restored radiosensitivity to a CD47-deficient Jurkat cells. Rhenium 0-2 CD47 molecule Homo sapiens 52-56 31421198-8 2019 The CD47 molecule is well known as a widely expressed cellular surface receptor activating the transudction of the ""don"t-eat-me"" signal. don"t-eat-me 117-129 CD47 molecule Homo sapiens 4-8 31632920-11 2019 Disrupting CD47 in PC3 cells increased resistance to etoposide but, in contrast to Jurkat cells, not to ionizing radiation. Etoposide 53-62 CD47 molecule Homo sapiens 11-15 30311702-12 2019 When human RBCs were preincubated with CD47 antibodies B6H12 or 2D3, phagocytosis was induced only after B6H12 incubation, indicating the lower phagocytic activity of porcine monocytes with human cells requires interaction between porcine SIRPA and human CD47. b6h12 55-60 CD47 molecule Homo sapiens 39-43 30920104-10 2019 Our findings provide new insights into the dual mechanism of action of IAP inhibitors that depends on oxygen level and are relevant to their therapeutic application in tumors. Oxygen 102-108 CD47 molecule Homo sapiens 71-74 31548591-6 2019 The top hit of the screen, the glutaminyl cyclase QPCTL, was validated and shown to modify the N-terminal glutamine of CD47. Glutamine 106-115 CD47 molecule Homo sapiens 119-123 31093697-3 2019 Modification of a self-signal trigging CD47-peptide on the NPs" surface decreased internalization by 10 times, (2.79 +- 0.21) x 104 Ru(bpy)3@SiO2-COOH and (0.28 +- 0.04) x 104 Ru(bpy)3@SiO2@CD47-peptide NPs per RAW264.7 macrophage (n = 5). Silicon Dioxide 141-145 CD47 molecule Homo sapiens 39-43 31093697-3 2019 Modification of a self-signal trigging CD47-peptide on the NPs" surface decreased internalization by 10 times, (2.79 +- 0.21) x 104 Ru(bpy)3@SiO2-COOH and (0.28 +- 0.04) x 104 Ru(bpy)3@SiO2@CD47-peptide NPs per RAW264.7 macrophage (n = 5). Silicon Dioxide 141-145 CD47 molecule Homo sapiens 190-194 31093697-3 2019 Modification of a self-signal trigging CD47-peptide on the NPs" surface decreased internalization by 10 times, (2.79 +- 0.21) x 104 Ru(bpy)3@SiO2-COOH and (0.28 +- 0.04) x 104 Ru(bpy)3@SiO2@CD47-peptide NPs per RAW264.7 macrophage (n = 5). Carbonic Acid 146-150 CD47 molecule Homo sapiens 39-43 31093697-3 2019 Modification of a self-signal trigging CD47-peptide on the NPs" surface decreased internalization by 10 times, (2.79 +- 0.21) x 104 Ru(bpy)3@SiO2-COOH and (0.28 +- 0.04) x 104 Ru(bpy)3@SiO2@CD47-peptide NPs per RAW264.7 macrophage (n = 5). Silicon Dioxide 185-189 CD47 molecule Homo sapiens 39-43 31093697-5 2019 Furthermore, the interaction between CD47-peptide and SIRPalpha as well as the changes of the remaining free SIRPalpha during the internalization process of Ru(bpy)3@SiO2@CD47-peptide NPs were quantitatively evaluated, providing direct experimental evidence of the longspeculated crucial CD47-SIRPalpha interaction for drug-nanocarriers to escape internalization by phagocytic cells. ru(bpy)3 157-165 CD47 molecule Homo sapiens 37-41 31093697-5 2019 Furthermore, the interaction between CD47-peptide and SIRPalpha as well as the changes of the remaining free SIRPalpha during the internalization process of Ru(bpy)3@SiO2@CD47-peptide NPs were quantitatively evaluated, providing direct experimental evidence of the longspeculated crucial CD47-SIRPalpha interaction for drug-nanocarriers to escape internalization by phagocytic cells. ru(bpy)3 157-165 CD47 molecule Homo sapiens 171-175 31093697-5 2019 Furthermore, the interaction between CD47-peptide and SIRPalpha as well as the changes of the remaining free SIRPalpha during the internalization process of Ru(bpy)3@SiO2@CD47-peptide NPs were quantitatively evaluated, providing direct experimental evidence of the longspeculated crucial CD47-SIRPalpha interaction for drug-nanocarriers to escape internalization by phagocytic cells. ru(bpy)3 157-165 CD47 molecule Homo sapiens 171-175 31093697-5 2019 Furthermore, the interaction between CD47-peptide and SIRPalpha as well as the changes of the remaining free SIRPalpha during the internalization process of Ru(bpy)3@SiO2@CD47-peptide NPs were quantitatively evaluated, providing direct experimental evidence of the longspeculated crucial CD47-SIRPalpha interaction for drug-nanocarriers to escape internalization by phagocytic cells. Silicon Dioxide 166-170 CD47 molecule Homo sapiens 37-41 31093697-5 2019 Furthermore, the interaction between CD47-peptide and SIRPalpha as well as the changes of the remaining free SIRPalpha during the internalization process of Ru(bpy)3@SiO2@CD47-peptide NPs were quantitatively evaluated, providing direct experimental evidence of the longspeculated crucial CD47-SIRPalpha interaction for drug-nanocarriers to escape internalization by phagocytic cells. Silicon Dioxide 166-170 CD47 molecule Homo sapiens 171-175 31093697-5 2019 Furthermore, the interaction between CD47-peptide and SIRPalpha as well as the changes of the remaining free SIRPalpha during the internalization process of Ru(bpy)3@SiO2@CD47-peptide NPs were quantitatively evaluated, providing direct experimental evidence of the longspeculated crucial CD47-SIRPalpha interaction for drug-nanocarriers to escape internalization by phagocytic cells. Silicon Dioxide 166-170 CD47 molecule Homo sapiens 171-175 31025548-0 2019 Syncytin 1, CD9, and CD47 regulating cell fusion to form PGCCs associated with cAMP/PKA and JNK signaling pathway. Cyclic AMP 79-83 CD47 molecule Homo sapiens 21-25 30878596-5 2019 We designed EpCAM (epithelial cell adhesion molecule)-targeted cationic liposome (LPP-P4-Ep) containing si-CD47 and si-PD-L1 could target high-EpCAM cancer cells and knockdown both CD47 and PD-L1 proteins. Silicon 5-7 CD47 molecule Homo sapiens 107-111 30878596-5 2019 We designed EpCAM (epithelial cell adhesion molecule)-targeted cationic liposome (LPP-P4-Ep) containing si-CD47 and si-PD-L1 could target high-EpCAM cancer cells and knockdown both CD47 and PD-L1 proteins. Silicon 5-7 CD47 molecule Homo sapiens 181-185 30845975-0 2019 The IAP antagonist birinapant potentiates bortezomib anti-myeloma activity in vitro and in vivo. birinapant 19-29 CD47 molecule Homo sapiens 4-7 30845975-0 2019 The IAP antagonist birinapant potentiates bortezomib anti-myeloma activity in vitro and in vivo. Bortezomib 42-52 CD47 molecule Homo sapiens 4-7 30845975-2 2019 METHODS: Interactions between the clinically relevant IAP (inhibitor of apoptosis protein) antagonist birinapant (TL32711) and the proteasome inhibitor bortezomib were investigated in multiple myeloma (MM) cell lines and primary cells, as well as in vivo models. birinapant 102-112 CD47 molecule Homo sapiens 54-57 30569825-3 2019 Interestingly, the biAb, constructed of a CD19 binding arm and a CD47 binding arm, inhibited BCR-mediated B-cell proliferation with an effect even more potent than a CD19 monoclonal antibody (mAb). Antibodies, Bispecific 19-23 CD47 molecule Homo sapiens 65-69 30681205-2 2019 In this study, we develop size-controllable stealth doxorubicin-loaded nanodrug coated with CD47 peptides (DOX/sNDF-CD47) based on supramolecular chemistry to overcome multiple biological barriers. Doxorubicin 52-63 CD47 molecule Homo sapiens 92-96 30681205-2 2019 In this study, we develop size-controllable stealth doxorubicin-loaded nanodrug coated with CD47 peptides (DOX/sNDF-CD47) based on supramolecular chemistry to overcome multiple biological barriers. Doxorubicin 52-63 CD47 molecule Homo sapiens 116-120 30681205-4 2019 Such structure transformation endows DOX/sNDF-CD47 with the ability of deep penetration in multicellular tumor spheroid, lysosomal escape, and nucleus localization, resulting in excellent cytotoxicity and drug resistance combating. Doxorubicin 37-40 CD47 molecule Homo sapiens 46-50 30681205-4 2019 Such structure transformation endows DOX/sNDF-CD47 with the ability of deep penetration in multicellular tumor spheroid, lysosomal escape, and nucleus localization, resulting in excellent cytotoxicity and drug resistance combating. sndf 41-45 CD47 molecule Homo sapiens 46-50 30681205-5 2019 In vivo experiments further confirmed that DOX/sNDF-CD47 has good tumor-targeting ability and can significantly improve therapeutic efficacy of DOX on xenograft tumor model. Doxorubicin 43-46 CD47 molecule Homo sapiens 52-56 30681205-5 2019 In vivo experiments further confirmed that DOX/sNDF-CD47 has good tumor-targeting ability and can significantly improve therapeutic efficacy of DOX on xenograft tumor model. Doxorubicin 144-147 CD47 molecule Homo sapiens 52-56 30419666-0 2018 [The Role of TSP-1-CD47 in ROS-mediated Pulmonary Fibrosis Induced by Paraquat]. Reactive Oxygen Species 27-30 CD47 molecule Homo sapiens 19-23 30664738-0 2019 Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated "don"t-eat-me" signal. don"t-eat-me 124-136 CD47 molecule Homo sapiens 109-113 30664738-4 2019 We show that stimulation with a CpG oligodeoxynucleotide, a Toll-like receptor 9 agonist, evokes changes in the central carbon metabolism of macrophages that enable antitumor activity, including engulfment of CD47+ cancer cells. Oligodeoxyribonucleotides 36-56 CD47 molecule Homo sapiens 209-213 30664738-4 2019 We show that stimulation with a CpG oligodeoxynucleotide, a Toll-like receptor 9 agonist, evokes changes in the central carbon metabolism of macrophages that enable antitumor activity, including engulfment of CD47+ cancer cells. Carbon 120-126 CD47 molecule Homo sapiens 209-213 30564353-1 2018 Presented herein is the case of a heavily pretreated patient with high-grade neuroendocrine prostate cancer that achieved a complete metabolic response on platinum-based chemotherapy after treatment with the dual CD-47 and SIRP-alpha inhibitor, RRx-001, in a Phase II clinical trial. Platinum 155-163 CD47 molecule Homo sapiens 213-218 30419666-14 2018 (6) Compared with PQ group, the cell viability of Anti-TSP1 group was significantly increased, and the morphology changed to normal cell morphology, and the mRNA level and the protein expression of TSP-1 and CD47 decreased, and the overexpression of ROS was inhibited, and the relative expression of FN and I collagen decreased. Reactive Oxygen Species 250-253 CD47 molecule Homo sapiens 208-212 30419666-15 2018 Conclusion: PQ stimulation induced morphological changes of A549 cells, increased expression of TSP-1, CD47, FN and type I collagen, and increased production of ROS.Neutralizing anti-TSP1 antibodies against TSP-1 can partially improve the above lesions. Primaquine 12-14 CD47 molecule Homo sapiens 103-107 30419666-16 2018 TSP-1-CD47 may be associated with oxidative stress-mediated PQ-induced pulmonary fibrosis. Primaquine 60-62 CD47 molecule Homo sapiens 6-10 29765073-6 2018 The accessibility to Rhesus D (RhD) and CD47 proteins on the cell surface was significantly decreased in crowding-assisted polymer grafting in comparison to non-crowded conditions. Polymers 123-130 CD47 molecule Homo sapiens 40-44 29979224-17 2018 Furthermore, we identified direct targeting of CD47 by microRNA-155 as a novel mechanism of myocardial and vascular contractile depression in sepsis, promoting microvascular endothelial cell and vascular insensitivity to thrombospondin-1-mediated inhibition of nitric oxide production and nitric oxide-mediated vasorelaxation, respectively. Nitric Oxide 261-273 CD47 molecule Homo sapiens 47-51 29979224-17 2018 Furthermore, we identified direct targeting of CD47 by microRNA-155 as a novel mechanism of myocardial and vascular contractile depression in sepsis, promoting microvascular endothelial cell and vascular insensitivity to thrombospondin-1-mediated inhibition of nitric oxide production and nitric oxide-mediated vasorelaxation, respectively. Nitric Oxide 289-301 CD47 molecule Homo sapiens 47-51 29788500-0 2018 Microvascular Dysfunction Following Multiwalled Carbon Nanotube Exposure Is Mediated by Thrombospondin-1 Receptor CD47. Carbon 48-54 CD47 molecule Homo sapiens 114-118 29788500-12 2018 CD47 activation likely disrupts nitric oxide ( NO) signaling and promotes leukocyte-endothelial interactions. Nitric Oxide 32-44 CD47 molecule Homo sapiens 0-4 30133535-5 2018 To this end, a novel CD47-blocking molecule, ALX148, was generated by fusing a modified SIRPalpha D1 domain to an inactive human IgG1 Fc. alx148 45-51 CD47 molecule Homo sapiens 21-25 30133535-10 2018 These studies revealed that CD47 blockade with ALX148 induces multiple responses that bridge innate and adaptive immunity. alx148 47-53 CD47 molecule Homo sapiens 28-32 30133535-13 2018 Taken together, these results show that ALX148 binds and blocks CD47 with high affinity, induces a broad antitumor immune response, and has a favorable safety profile. alx148 40-46 CD47 molecule Homo sapiens 64-68 29939755-0 2018 A Glutamine-Rich Carrier Efficiently Delivers Anti-CD47 siRNA Driven by a "Glutamine Trap" To Inhibit Lung Cancer Cell Growth. Glutamine 2-11 CD47 molecule Homo sapiens 51-55 29600425-2 2018 RESULTS: The novel bispecific antibody fusion protein, denoted as Bi-SP could simultaneously bind to EGFR and CD47 and exhibited potent phagocytosis-stimulation effects in vitro. bi-sp 66-71 CD47 molecule Homo sapiens 110-114 29600425-5 2018 CONCLUSIONS: Bi-SP with improved therapeutic index has the potential to treat CD47+ and EGFR+ cancers in clinics. bi-sp 13-18 CD47 molecule Homo sapiens 78-82 29748606-6 2018 Soluble CC2C6 induces CD47-dependent cell death in a manner consistent with immobilized B6H12, which is characterized by mitochondrial deficiencies but is independent of caspase activation. cc2c6 8-13 CD47 molecule Homo sapiens 22-26 29748606-7 2018 Titration studies indicated that CC2C6 shares a common CD47-epitope with B6H12. b6h12 73-78 CD47 molecule Homo sapiens 55-59 29087049-4 2018 At the time of reperfusion, indocyanine green-based in vivo imaging showed that CD47mAb-treated organs had greater and more uniform reperfusion. Indocyanine Green 28-45 CD47 molecule Homo sapiens 80-84 28337964-13 2017 Taken together, CD47 might be a novel target to enhance anti-PD-1 and CLTA-4 efficacy in esophageal squamous cell cancer. clta 70-74 CD47 molecule Homo sapiens 16-20 29757588-5 2018 Blood samples from 61 adult patients with type 1 diabetes and 61 sex and age-matched healthy controls were tested to count two types of Tregs, namely naturally occurring and inducible types, according to the expression of cell surface markers of CD4/CD25/CD47-FITC/PE/APC and intracellular markers of FoxP3/Helios-PE-CY5/eFlour450 by flow cytometry, respectively.We also investigated the relation between expression of such markers with HbA1c, urine albumin/creatinine ratio (UACR), and common carotid intima thickness (CIMT). Fluorescein-5-isothiocyanate 260-264 CD47 molecule Homo sapiens 255-259 29536167-4 2018 By immunohistochemistry of CD47, high, low, and negative expression was observed in 24, 63, and 12% of EBVaGC (n = 41), while 11, 49, and 39% of EBV-negative gastric cancer (n = 262), respectively, indicating that high expression of CD47 in cancer cells was significantly frequent and increased in EBVaGC (P = 0.043). ebvagc 103-109 CD47 molecule Homo sapiens 27-31 29536167-5 2018 In contrast to EBV-negative gastric carcinoma in which no significant correlation was observed between CD47 and survival, high expression of CD47 correlated significantly with worse disease-specific survival (P = 0.011) and overall survival (P = 0.013) in EBVaGC. ebvagc 256-262 CD47 molecule Homo sapiens 141-145 28556300-6 2017 The resulting SNIPER(ABL)-39, in which dasatinib is conjugated to an IAP ligand LCL161 derivative by polyethylene glycol (PEG) x 3 linker, shows a potent activity to degrade the BCR-ABL protein. Dasatinib 39-48 CD47 molecule Homo sapiens 69-72 32264429-2 2017 In this study, we modified the surfaces of graphene oxide (GO) nanosheets with a CD47-like SIRPalpha-binding peptide (SP). graphene oxide 43-57 CD47 molecule Homo sapiens 81-85 32264429-2 2017 In this study, we modified the surfaces of graphene oxide (GO) nanosheets with a CD47-like SIRPalpha-binding peptide (SP). graphene oxide 59-61 CD47 molecule Homo sapiens 81-85 28662400-0 2017 Linker-free covalent immobilization of heparin, SDF-1alpha, and CD47 on PTFE surface for antithrombogenicity, endothelialization and anti-inflammation. Polytetrafluoroethylene 72-76 CD47 molecule Homo sapiens 64-68 28556300-6 2017 The resulting SNIPER(ABL)-39, in which dasatinib is conjugated to an IAP ligand LCL161 derivative by polyethylene glycol (PEG) x 3 linker, shows a potent activity to degrade the BCR-ABL protein. Polyethylene Glycols 101-120 CD47 molecule Homo sapiens 69-72 28556300-6 2017 The resulting SNIPER(ABL)-39, in which dasatinib is conjugated to an IAP ligand LCL161 derivative by polyethylene glycol (PEG) x 3 linker, shows a potent activity to degrade the BCR-ABL protein. Polyethylene Glycols 122-125 CD47 molecule Homo sapiens 69-72 28161480-7 2017 Inhibiting CD47 using monoclonal antibodies has been shown as an effective strategy to treat PDAC in vivo. pdac 93-97 CD47 molecule Homo sapiens 11-15 28522599-6 2017 Such pathways extend to mechanosensing by the nuclear lamina, which is known to influence signaling by soluble retinoids that can regulate the macrophage SIRPalpha, the receptor for CD47. Retinoids 111-120 CD47 molecule Homo sapiens 182-186 28161480-8 2017 However, CD47 inhibition effectively slowed tumor growth only in combination with Gemcitabine or Abraxane. gemcitabine 82-93 CD47 molecule Homo sapiens 9-13 28161480-9 2017 In this work, we present the generation of multifunctionalized iron oxide magnetic nanoparticles (MNPs) that include the anti-CD47 antibody and the chemotherapeutic drug Gemcitabine in a single formulation. ferric oxide 63-73 CD47 molecule Homo sapiens 126-130 28378740-5 2017 We show that a set of active constituent enhancers, located within the two CD47 SEs, regulate CD47 expression in different cancer cell types and that disruption of CD47 SEs reduces CD47 gene expression. ses 80-83 CD47 molecule Homo sapiens 75-79 28351890-5 2017 Meanwhile, reactive oxygen species and inactivation of mTOR were shown to be involved in autophagy initiation in SIRPalphaD1-Fc-treated cells, indicating a probable mechanism for autophagy activation after targeting CD47 by SIRPalphaD1-Fc. Reactive Oxygen Species 11-34 CD47 molecule Homo sapiens 216-220 28351890-7 2017 In addition, simultaneously targeting both CD47 and autophagy in NSCLC xenograft models elicited enhanced antitumor effects, with recruitment of macrophages, activated caspase-3, and overproduction of ROS at the tumor site. Reactive Oxygen Species 201-204 CD47 molecule Homo sapiens 43-47 29050218-4 2017 Similarly, melanoma cells selected for resistance to the BRAF inhibitor vemurafenib expressed higher levels of CD47. Vemurafenib 72-83 CD47 molecule Homo sapiens 111-115 29050218-9 2017 Functional studies showed that melanoma cells resistant to vemurafenib were more susceptible to macrophage phagocytosis when CD47 was blocked. Vemurafenib 59-70 CD47 molecule Homo sapiens 125-129 28393401-13 2017 The tyrosine phosphorylation level of SIRP-alpha in activated THP-1 cells was further increased in the case of co-expression of CD47/TFPI than in individual non-expression or expression of CD47 or TFPI alone. Tyrosine 4-12 CD47 molecule Homo sapiens 128-132 28393401-13 2017 The tyrosine phosphorylation level of SIRP-alpha in activated THP-1 cells was further increased in the case of co-expression of CD47/TFPI than in individual non-expression or expression of CD47 or TFPI alone. Tyrosine 4-12 CD47 molecule Homo sapiens 189-193 28393401-14 2017 CONCLUSIONS: When hCD47 was expressed, the expression of hTFPI leaded to tyrosine phosphorylation of SIRP-alpha in activated THP-1 cells via hTSP-1 inhibition, and consequently, it might improve the effect of hCD47-SIRP-a signaling. Tyrosine 73-81 CD47 molecule Homo sapiens 18-23 28378740-5 2017 We show that a set of active constituent enhancers, located within the two CD47 SEs, regulate CD47 expression in different cancer cell types and that disruption of CD47 SEs reduces CD47 gene expression. ses 80-83 CD47 molecule Homo sapiens 94-98 28378740-5 2017 We show that a set of active constituent enhancers, located within the two CD47 SEs, regulate CD47 expression in different cancer cell types and that disruption of CD47 SEs reduces CD47 gene expression. ses 80-83 CD47 molecule Homo sapiens 94-98 28378740-5 2017 We show that a set of active constituent enhancers, located within the two CD47 SEs, regulate CD47 expression in different cancer cell types and that disruption of CD47 SEs reduces CD47 gene expression. ses 80-83 CD47 molecule Homo sapiens 94-98 28378740-5 2017 We show that a set of active constituent enhancers, located within the two CD47 SEs, regulate CD47 expression in different cancer cell types and that disruption of CD47 SEs reduces CD47 gene expression. ses 169-172 CD47 molecule Homo sapiens 75-79 28378740-5 2017 We show that a set of active constituent enhancers, located within the two CD47 SEs, regulate CD47 expression in different cancer cell types and that disruption of CD47 SEs reduces CD47 gene expression. ses 169-172 CD47 molecule Homo sapiens 94-98 28378740-5 2017 We show that a set of active constituent enhancers, located within the two CD47 SEs, regulate CD47 expression in different cancer cell types and that disruption of CD47 SEs reduces CD47 gene expression. ses 169-172 CD47 molecule Homo sapiens 94-98 28378740-5 2017 We show that a set of active constituent enhancers, located within the two CD47 SEs, regulate CD47 expression in different cancer cell types and that disruption of CD47 SEs reduces CD47 gene expression. ses 169-172 CD47 molecule Homo sapiens 94-98 28220078-5 2017 We developed a detailed rule-based computational model to inquire if TSP1-CD47 signaling through VEGF had downstream effects upon ERK1/2 and calcium. Calcium 141-148 CD47 molecule Homo sapiens 74-78 28061465-6 2017 LicMABs selectively bind CD33-expressing cells even in the presence of a large CD33-negative CD47-positive antigen sink, stimulate phagocytosis of AML cells and eliminate AML cell lines and primary, patient-derived AML cells. licmabs 0-7 CD47 molecule Homo sapiens 93-97 28186432-2 2017 MATERIAL & METHODS: An immunized murine antibody phage display library was constructed and screened to isolate anti-CD47 binders. Adenosine Monophosphate 10-13 CD47 molecule Homo sapiens 120-124 28220078-6 2017 Our Simulations suggest that enhanced degradation of VEGFR2 initiated by the binding of TSP1 to CD47 is sufficient to explain the inhibition of VEGFR2 phosphorylation, calcium elevation, and ERK1/2 activation downstream of VEGF. Calcium 168-175 CD47 molecule Homo sapiens 96-100 27730543-14 2016 miR-133a targeting CD47 could be a new direction in the diagnosis and treatment of laryngeal carcinoma. mir-133a 0-8 CD47 molecule Homo sapiens 19-23 29410884-11 2017 Furthermore, we showed that CD47 is highly expressed in CIS+ NMIBC compared to CIS- NMIBC. cis+ nmibc 56-66 CD47 molecule Homo sapiens 28-32 28268219-2 2017 Herein, we show that Treg cells directly protect dopaminergic neurons against 1-methyl-4-phenylpyridinium (MPP+) neurotoxicity via an interaction between the two transmembrane proteins CD47 and signal regulatory protein alpha (SIRPA). 1-Methyl-4-phenylpyridinium 78-105 CD47 molecule Homo sapiens 185-189 28268219-11 2017 Silencing CD47 gene in Treg cells impaired the ability of Treg cells to protect dopaminergic neurons against MPP+ toxicity. mangion-purified polysaccharide (Candida albicans) 109-113 CD47 molecule Homo sapiens 10-14 28268219-15 2017 CONCLUSION: Treg cells protect dopaminergic neurons against MPP+ neurotoxicity by a cell-to-cell contact mechanism underlying CD47-SIRPA interaction and Rac1/Akt activation. mangion-purified polysaccharide (Candida albicans) 60-64 CD47 molecule Homo sapiens 126-130 27671753-0 2016 Silencing of CD47 and SIRPalpha by Polypurine reverse Hoogsteen hairpins to promote MCF-7 breast cancer cells death by PMA-differentiated THP-1 cells. polypurine 35-45 CD47 molecule Homo sapiens 13-17 27671753-2 2016 In the present work, we designed Polypurine reverse Hoogsteen hairpins, PPRHs, to silence the expression of CD47 in tumor cells and SIRPalpha in macrophages with the aim to eliminate tumor cells by macrophages in co-culture experiments. polypurine 33-43 CD47 molecule Homo sapiens 108-112 27110670-0 2016 Purification of CD47-streptavidin fusion protein from bacterial lysate using biotin-agarose affinity chromatography. Biotin 77-83 CD47 molecule Homo sapiens 16-20 27110670-5 2016 After bacteria transformation, the CD47-SA fusion protein was expressed by isopropyl-beta-d-thiogalactopyranoside (IPTG) induction. Isopropyl Thiogalactoside 75-113 CD47 molecule Homo sapiens 35-39 27110670-5 2016 After bacteria transformation, the CD47-SA fusion protein was expressed by isopropyl-beta-d-thiogalactopyranoside (IPTG) induction. Isopropyl Thiogalactoside 115-119 CD47 molecule Homo sapiens 35-39 27110670-0 2016 Purification of CD47-streptavidin fusion protein from bacterial lysate using biotin-agarose affinity chromatography. Sepharose 84-91 CD47 molecule Homo sapiens 16-20 27110670-6 2016 The collected bacteria lysate was loaded on biotinylated agarose to proceed the purification of CD47-SA fusion protein. Sepharose 57-64 CD47 molecule Homo sapiens 96-100 27110670-8 2016 Instead, using low concentration of the non-ionic detergent Triton X-100 followed with alkaline buffer could efficiently weaken the binding between biotin and coreSA, thereby eluting out CD47-SA fusion protein from the biotin agarose column. Octoxynol 60-72 CD47 molecule Homo sapiens 187-191 27110670-8 2016 Instead, using low concentration of the non-ionic detergent Triton X-100 followed with alkaline buffer could efficiently weaken the binding between biotin and coreSA, thereby eluting out CD47-SA fusion protein from the biotin agarose column. Biotin 148-154 CD47 molecule Homo sapiens 187-191 27110670-8 2016 Instead, using low concentration of the non-ionic detergent Triton X-100 followed with alkaline buffer could efficiently weaken the binding between biotin and coreSA, thereby eluting out CD47-SA fusion protein from the biotin agarose column. biotin agarose 219-233 CD47 molecule Homo sapiens 187-191 27110670-3 2016 To make sure CD47 functionality is intact under the process of protein conjugation, CD47-streptavidin fusion protein was expressed and purified because it can easily bind to biotin-tagged materials via the unique biotin-streptavidin affinity. Biotin 174-180 CD47 molecule Homo sapiens 84-88 27110670-3 2016 To make sure CD47 functionality is intact under the process of protein conjugation, CD47-streptavidin fusion protein was expressed and purified because it can easily bind to biotin-tagged materials via the unique biotin-streptavidin affinity. Biotin 213-219 CD47 molecule Homo sapiens 13-17 27110670-3 2016 To make sure CD47 functionality is intact under the process of protein conjugation, CD47-streptavidin fusion protein was expressed and purified because it can easily bind to biotin-tagged materials via the unique biotin-streptavidin affinity. Biotin 213-219 CD47 molecule Homo sapiens 84-88 27331362-3 2016 Steatotic livers are more susceptible to ischemia-reperfusion injury (IRI), which is exacerbated by the thrombospondin-1/CD47 pathway through inhibition of nitric oxide signaling. Nitric Oxide 156-168 CD47 molecule Homo sapiens 121-125 27331362-9 2016 RESULTS: Administration of CD47mAb400 to donor livers increased recipient survival and resulted in significant reduction of serum transaminases, bilirubin, triphosphate nick-end labeling staining, caspase-3 activity, oxidative and nitrosative stresses, and proinflammatory cytokine expression of TNF-alpha, IL-6 and IL-1beta. Bilirubin 145-154 CD47 molecule Homo sapiens 27-31 27331362-9 2016 RESULTS: Administration of CD47mAb400 to donor livers increased recipient survival and resulted in significant reduction of serum transaminases, bilirubin, triphosphate nick-end labeling staining, caspase-3 activity, oxidative and nitrosative stresses, and proinflammatory cytokine expression of TNF-alpha, IL-6 and IL-1beta. triphosphoric acid 156-168 CD47 molecule Homo sapiens 27-31 26609483-3 2015 There are six potential N-glycosylation sites on CD47, and glycosylation is known to be necessary for its membrane localization. Nitrogen 24-25 CD47 molecule Homo sapiens 49-53 26351778-7 2016 Interestingly, anti-CD47 antibody synergized the effect of HCC cells to chemotherapeutic drugs including doxorubicin and cisplatin. Doxorubicin 105-116 CD47 molecule Homo sapiens 20-24 26351778-7 2016 Interestingly, anti-CD47 antibody synergized the effect of HCC cells to chemotherapeutic drugs including doxorubicin and cisplatin. Cisplatin 121-130 CD47 molecule Homo sapiens 20-24 29859029-1 2016 To investigate the effect that folic acid-modified polyrotaxanes(FPP) transfered siRNA CD47 to inhibit melanoma proliferation, the expression of CD47 in clinical melanoma patients was tested by Western blot and RT-PCR, respectively. Folic Acid 31-41 CD47 molecule Homo sapiens 87-91 29859029-1 2016 To investigate the effect that folic acid-modified polyrotaxanes(FPP) transfered siRNA CD47 to inhibit melanoma proliferation, the expression of CD47 in clinical melanoma patients was tested by Western blot and RT-PCR, respectively. Folic Acid 31-41 CD47 molecule Homo sapiens 145-149 29859029-1 2016 To investigate the effect that folic acid-modified polyrotaxanes(FPP) transfered siRNA CD47 to inhibit melanoma proliferation, the expression of CD47 in clinical melanoma patients was tested by Western blot and RT-PCR, respectively. Rotaxanes 51-64 CD47 molecule Homo sapiens 87-91 29859029-1 2016 To investigate the effect that folic acid-modified polyrotaxanes(FPP) transfered siRNA CD47 to inhibit melanoma proliferation, the expression of CD47 in clinical melanoma patients was tested by Western blot and RT-PCR, respectively. Rotaxanes 51-64 CD47 molecule Homo sapiens 145-149 26867178-5 2016 We find that phosphatidylserine-exposing erythrocytes are reticulocytes expressing high levels of CD47, a "do-not-eat-me" signal, but the binding of anti-phosphatidylserine antibodies mediates their phagocytosis, contributing to anemia. do-not-eat-me 107-120 CD47 molecule Homo sapiens 98-102 26534964-2 2015 SIRPalpha ligation by a broadly expressed transmembrane protein, CD47, results in phosphorylation of the cytoplasmic immunoreceptor tyrosine-based inhibitory motifs, resulting in the inhibition of NF-kappaB signaling in macrophages. Tyrosine 132-140 CD47 molecule Homo sapiens 65-69 26573233-6 2015 Molecular analysis suggests a reduction in the CD47/SIRPalpha pathway by PD-1 blockade, which regulates MDSCs, TAMs, dendritic cell as well as effector T cells. tams 111-115 CD47 molecule Homo sapiens 47-51 26488923-4 2015 Biomimetic RBC membrane-coated Fe(3)O(4) nanoparticles (Fe(3)O(4) @RBC NPs) rely on CD47, which is a "don"t eat me" marker on the RBC surface, to escape immune clearance through interactions with the signal regulatory protein-alpha (SIRP-alpha) receptor. fe(3) 31-36 CD47 molecule Homo sapiens 84-88 26488923-4 2015 Biomimetic RBC membrane-coated Fe(3)O(4) nanoparticles (Fe(3)O(4) @RBC NPs) rely on CD47, which is a "don"t eat me" marker on the RBC surface, to escape immune clearance through interactions with the signal regulatory protein-alpha (SIRP-alpha) receptor. fe(3) 56-61 CD47 molecule Homo sapiens 84-88 27125525-13 2016 Deferoxamine treatment attenuated the process of hematoma resolution by reducing member attack complex formation and inhibiting CD47 loss in the clot. Deferoxamine 0-12 CD47 molecule Homo sapiens 128-132 25902734-12 2015 CONCLUSIONS: NF-kappaB-mediated CD47 up-regulation promotes sorafenib resistance, and targeting CD47 in combination with sorafenib is an attractive therapeutic regimen for the treatment of HCC patients. Sorafenib 60-69 CD47 molecule Homo sapiens 32-36 25482981-3 2015 We investigated whether blocking the CD47/thrombospondin-1 inhibitory action on nitric oxide signaling with a monoclonal antibody specific to CD47 (CD47mAb400) would reduce IRI in liver grafts. Nitric Oxide 80-92 CD47 molecule Homo sapiens 37-41 26085683-7 2015 Disruption of plasma membrane lipid rafts with methyl-beta-cyclodextrin diffuses CD47 clusters, leading to a decrease in the cell binding avidity to SIRPalpha and a concomitant increase in cells being engulfed by macrophages. methyl-beta-cyclodextrin 47-71 CD47 molecule Homo sapiens 81-85 25482981-3 2015 We investigated whether blocking the CD47/thrombospondin-1 inhibitory action on nitric oxide signaling with a monoclonal antibody specific to CD47 (CD47mAb400) would reduce IRI in liver grafts. Nitric Oxide 80-92 CD47 molecule Homo sapiens 142-146 25482981-3 2015 We investigated whether blocking the CD47/thrombospondin-1 inhibitory action on nitric oxide signaling with a monoclonal antibody specific to CD47 (CD47mAb400) would reduce IRI in liver grafts. Nitric Oxide 80-92 CD47 molecule Homo sapiens 148-158 25482981-10 2015 The CD47mAb400-treated group showed lower serum transaminases, bilirubin, oxidative stress, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling staining, caspase-3 activity, and proinflammatory cytokine expression of tumor necrosis factor alpha, interleukin-1beta, and interleukin-6. Bilirubin 63-72 CD47 molecule Homo sapiens 4-14 25482981-10 2015 The CD47mAb400-treated group showed lower serum transaminases, bilirubin, oxidative stress, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling staining, caspase-3 activity, and proinflammatory cytokine expression of tumor necrosis factor alpha, interleukin-1beta, and interleukin-6. deoxyuridine triphosphate 139-164 CD47 molecule Homo sapiens 4-14 25747479-0 2015 CD47-dependent regulation of H2S biosynthesis and signaling in T cells. Hydrogen Sulfide 29-32 CD47 molecule Homo sapiens 0-4 25164878-11 2014 The results suggest that tuftsin-based, enediyne-energized, and EGFR-targeting fusion proteins exert highly antitumor efficacy with CD47 modulation. Enediynes 40-48 CD47 molecule Homo sapiens 132-136 25747479-7 2015 Studies of the receptor CD47 have revealed the first endogenous inhibitory signaling pathway that regulates H2S signaling in T cells. Hydrogen Sulfide 108-111 CD47 molecule Homo sapiens 24-28 25747479-8 2015 Binding of the secreted protein thrombospondin-1 to CD47 elicits signals that block the stimulatory activity of exogenous H2S on T cell activation and limit the induction of CSE and CBS gene expression. Hydrogen Sulfide 122-125 CD47 molecule Homo sapiens 52-56 24983310-6 2014 RESULTS: CD47mAb perfusion of donor kidneys resulted in marked improvement in posttransplant survival, lower levels of serum creatinine, blood urea nitrogen, phosphorus and magnesium, and less histological evidence of injury. Creatinine 125-135 CD47 molecule Homo sapiens 9-13 24983310-6 2014 RESULTS: CD47mAb perfusion of donor kidneys resulted in marked improvement in posttransplant survival, lower levels of serum creatinine, blood urea nitrogen, phosphorus and magnesium, and less histological evidence of injury. Urea 143-147 CD47 molecule Homo sapiens 9-13 24983310-6 2014 RESULTS: CD47mAb perfusion of donor kidneys resulted in marked improvement in posttransplant survival, lower levels of serum creatinine, blood urea nitrogen, phosphorus and magnesium, and less histological evidence of injury. Nitrogen 148-156 CD47 molecule Homo sapiens 9-13 24983310-6 2014 RESULTS: CD47mAb perfusion of donor kidneys resulted in marked improvement in posttransplant survival, lower levels of serum creatinine, blood urea nitrogen, phosphorus and magnesium, and less histological evidence of injury. Phosphorus 158-168 CD47 molecule Homo sapiens 9-13 24983310-6 2014 RESULTS: CD47mAb perfusion of donor kidneys resulted in marked improvement in posttransplant survival, lower levels of serum creatinine, blood urea nitrogen, phosphorus and magnesium, and less histological evidence of injury. Magnesium 173-182 CD47 molecule Homo sapiens 9-13 24523067-7 2014 Suppression of CD47 by morpholino approach suppressed growth of HCC in vivo and exerted a chemosensitization effect through blockade of CTSS/PAR2 signaling. Morpholinos 23-33 CD47 molecule Homo sapiens 15-19 24911792-6 2014 We investigated whether ROS generation is the initial event of CD47-mediated G1 arrest because ROS scavenger NAC effectively abrogated the majority of CD47-mediated responses but SB203580 and SP600125 did not block ROS production. Reactive Oxygen Species 95-98 CD47 molecule Homo sapiens 151-155 24911792-6 2014 We investigated whether ROS generation is the initial event of CD47-mediated G1 arrest because ROS scavenger NAC effectively abrogated the majority of CD47-mediated responses but SB203580 and SP600125 did not block ROS production. Reactive Oxygen Species 95-98 CD47 molecule Homo sapiens 151-155 24911792-0 2014 Ligation of CD47 induces G1 arrest in EBV-transformed B cells through ROS generation, p38 MAPK/JNK activation, and Tap73 upregulation. Reactive Oxygen Species 70-73 CD47 molecule Homo sapiens 12-16 24911792-7 2014 Taken together, we concluded that CD47 ligation on EBV-transformed B cells led to G1 arrest by ROS generation and, subsequently, there was p38 MAPK/JNK pathway activation, ER stress triggering, and TAp73 upregulation. Reactive Oxygen Species 95-98 CD47 molecule Homo sapiens 34-38 24911792-5 2014 Moreover, reactive oxygen species (ROS) generation and upregulation of both TAp73 and ER stress sensor proteins were detected after CD47 ligation, and p38 inhibitor SB203580 and JNK inhibitor SP600125 blocked upregulation of TAp73 and cell cycle arrest. Reactive Oxygen Species 10-33 CD47 molecule Homo sapiens 132-136 24911792-5 2014 Moreover, reactive oxygen species (ROS) generation and upregulation of both TAp73 and ER stress sensor proteins were detected after CD47 ligation, and p38 inhibitor SB203580 and JNK inhibitor SP600125 blocked upregulation of TAp73 and cell cycle arrest. Reactive Oxygen Species 35-38 CD47 molecule Homo sapiens 132-136 24922625-4 2014 METHODS AND RESULTS: In experimental LVHF TSP1-CD47 signaling is increased concurrent with up-regulation of cardiac histone deacetylase 3 (HDAC3). lvhf 37-41 CD47 molecule Homo sapiens 47-51 24911792-5 2014 Moreover, reactive oxygen species (ROS) generation and upregulation of both TAp73 and ER stress sensor proteins were detected after CD47 ligation, and p38 inhibitor SB203580 and JNK inhibitor SP600125 blocked upregulation of TAp73 and cell cycle arrest. SB 203580 165-173 CD47 molecule Homo sapiens 132-136 24911792-5 2014 Moreover, reactive oxygen species (ROS) generation and upregulation of both TAp73 and ER stress sensor proteins were detected after CD47 ligation, and p38 inhibitor SB203580 and JNK inhibitor SP600125 blocked upregulation of TAp73 and cell cycle arrest. pyrazolanthrone 192-200 CD47 molecule Homo sapiens 132-136 24911792-6 2014 We investigated whether ROS generation is the initial event of CD47-mediated G1 arrest because ROS scavenger NAC effectively abrogated the majority of CD47-mediated responses but SB203580 and SP600125 did not block ROS production. Reactive Oxygen Species 24-27 CD47 molecule Homo sapiens 63-67 24418252-7 2014 Further work has identified that TSP1-CD47 signaling stimulates enzymatic reactive oxygen species (ROS) production to further limit blood flow and promote vascular disease. Reactive Oxygen Species 74-97 CD47 molecule Homo sapiens 38-42 24418252-7 2014 Further work has identified that TSP1-CD47 signaling stimulates enzymatic reactive oxygen species (ROS) production to further limit blood flow and promote vascular disease. Reactive Oxygen Species 99-102 CD47 molecule Homo sapiens 38-42 24922625-7 2014 Conversely, antibody blocking of CD47 activation, or pharmacologic inhibition of CaMKII, suppressed HDAC3 expression, decreased myocyte hypertrophy, and mitigated established LVHF. lvhf 175-179 CD47 molecule Homo sapiens 33-37 24006483-8 2013 Unexpectedly, Jurkat CD47 null cells exhibited a striking defect in beta1 and beta2 integrin activation in response to Mn(2+) or Mg(2+)/ethylene glycol tetraacetic acid treatment. Manganese(2+) 119-125 CD47 molecule Homo sapiens 21-25 23975537-9 2014 Correlation analyses revealed that the SDS score was positively associated with serum IAP levels but negatively associated with CD3 and CD4 levels. sds 39-42 CD47 molecule Homo sapiens 86-89 24215318-3 2014 Engagement of SIRPalpha by CD47 provides a downregulatory signal that inhibits host cell phagocytosis, and CD47 therefore functions as a "don"t-eat-me" signal. don"t-eat-me 138-150 CD47 molecule Homo sapiens 107-111 23948164-2 2013 Here, we begin to profile, at the transcriptional, translational and cell signaling level, the inflammatory cell response when blood interacts with CD47 modified polyvinyl chloride (PVC) (CD47-PVC). Polyvinyl Chloride 162-180 CD47 molecule Homo sapiens 148-152 23948164-2 2013 Here, we begin to profile, at the transcriptional, translational and cell signaling level, the inflammatory cell response when blood interacts with CD47 modified polyvinyl chloride (PVC) (CD47-PVC). Polyvinyl Chloride 162-180 CD47 molecule Homo sapiens 188-192 24006483-8 2013 Unexpectedly, Jurkat CD47 null cells exhibited a striking defect in beta1 and beta2 integrin activation in response to Mn(2+) or Mg(2+)/ethylene glycol tetraacetic acid treatment. magnesium ion 129-135 CD47 molecule Homo sapiens 21-25 24447619-4 2013 Anti-CD47 antibodies were conjugated with p-isothiocyanatobenzyldesferrioxamine (Df-Bz-NCS) and labeled with 89Zr. 4-isothiocyanatobenzyl-desferrioxamine 42-79 CD47 molecule Homo sapiens 5-9 24447619-4 2013 Anti-CD47 antibodies were conjugated with p-isothiocyanatobenzyldesferrioxamine (Df-Bz-NCS) and labeled with 89Zr. 4-isothiocyanatobenzyl-desferrioxamine 81-90 CD47 molecule Homo sapiens 5-9 24006483-8 2013 Unexpectedly, Jurkat CD47 null cells exhibited a striking defect in beta1 and beta2 integrin activation in response to Mn(2+) or Mg(2+)/ethylene glycol tetraacetic acid treatment. Egtazic Acid 136-168 CD47 molecule Homo sapiens 21-25 23774794-5 2013 Anti-CD47 siRNA was encapsulated in a liposome-protamine-hyaluronic acid (LPH) nanoparticle (NP) formulation to address the challenge of targeted delivery of siRNA-based therapeutics in vivo. Hyaluronic Acid 57-72 CD47 molecule Homo sapiens 5-9 23774794-5 2013 Anti-CD47 siRNA was encapsulated in a liposome-protamine-hyaluronic acid (LPH) nanoparticle (NP) formulation to address the challenge of targeted delivery of siRNA-based therapeutics in vivo. lph 74-77 CD47 molecule Homo sapiens 5-9 23774794-6 2013 Efficient silencing of CD47 in tumor tissues with systemic administration of LPH(CD47) also significantly inhibited the growth of melanoma tumors. lph 77-80 CD47 molecule Homo sapiens 23-27 23774794-6 2013 Efficient silencing of CD47 in tumor tissues with systemic administration of LPH(CD47) also significantly inhibited the growth of melanoma tumors. lph 77-80 CD47 molecule Homo sapiens 81-85 23774794-8 2013 Moreover, no hematopoietic toxicity was observed in the animals that received multiple doses of LPH(CD47). lph 96-99 CD47 molecule Homo sapiens 100-104 23976822-9 2013 It is also shown that CD47 is very slightly up-regulated by blasts exposed to AbBNPs. abbnps 78-84 CD47 molecule Homo sapiens 22-26 23991206-12 2013 LDL cholesterol increased cell surface expression of CXCR4, G-CSFR affecting HSPC migration, and CD47 mediating protection from phagocytosis by immune cells. Cholesterol 4-15 CD47 molecule Homo sapiens 97-101 23826770-6 2013 The FabOX117 binding site is distinct from the region in domain 1 which interacts with CD47, the physiological ligand for both SIRPgamma and SIRPalpha but not SIRPbeta. fabox117 4-12 CD47 molecule Homo sapiens 87-91 23853587-8 2013 Like TSP-1, BAD-1 blocks activation of T cells in a manner requiring the heparan sulfate-modified surface molecule CD47, and impairs effector functions. Heparitin Sulfate 73-88 CD47 molecule Homo sapiens 115-119 21343308-0 2011 Heparan sulfate modification of the transmembrane receptor CD47 is necessary for inhibition of T cell receptor signaling by thrombospondin-1. Heparitin Sulfate 0-15 CD47 molecule Homo sapiens 59-63 21901250-7 2012 In addition, bufalin treatment resulted in an increase of the Bax/Bcl-2 (or Bcl-xL) ratio and caused down-regulation of inhibitor of apoptosis protein (IAP) family members. bufalin 25-32 CD47 molecule Homo sapiens 144-174 21901250-7 2012 In addition, bufalin treatment resulted in an increase of the Bax/Bcl-2 (or Bcl-xL) ratio and caused down-regulation of inhibitor of apoptosis protein (IAP) family members. bufalin 25-32 CD47 molecule Homo sapiens 176-179 21429575-0 2011 The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation. Polymers 28-35 CD47 molecule Homo sapiens 14-18 21429575-4 2011 Recombinant CD47 was appended to polyvinyl chloride (PVC) or polyurethane (PU) surfaces via photoactivation chemistry. Polyvinyl Chloride 33-51 CD47 molecule Homo sapiens 12-16 21429575-4 2011 Recombinant CD47 was appended to polyvinyl chloride (PVC) or polyurethane (PU) surfaces via photoactivation chemistry. Polyvinyl Chloride 53-56 CD47 molecule Homo sapiens 12-16 21429575-4 2011 Recombinant CD47 was appended to polyvinyl chloride (PVC) or polyurethane (PU) surfaces via photoactivation chemistry. Polyurethanes 61-73 CD47 molecule Homo sapiens 12-16 21429575-4 2011 Recombinant CD47 was appended to polyvinyl chloride (PVC) or polyurethane (PU) surfaces via photoactivation chemistry. Polyurethanes 75-77 CD47 molecule Homo sapiens 12-16 23087362-8 2012 CONCLUSIONS: Our data suggest a highly regulated process of reactive oxygen species stimulation and blood flow regulation promoted through a direct TSP1/CD47-mediated activation of Nox1. Reactive Oxygen Species 60-83 CD47 molecule Homo sapiens 153-157 22648449-7 2012 In xenotransplantation models, anti-CD47 antibodies inhibited the growth of RPMI 8226 myeloma cells and led to tumor regression (42/57 mice), implicating the eradication of myeloma-initiating cells. rpmi 76-80 CD47 molecule Homo sapiens 36-40 22613135-4 2012 We appended a poly-lysine tag to the C-terminus of recombinant CD47 (CD47L) allowing for covalent linkage to the polymer. Polylysine 14-25 CD47 molecule Homo sapiens 63-67 22613135-4 2012 We appended a poly-lysine tag to the C-terminus of recombinant CD47 (CD47L) allowing for covalent linkage to the polymer. Polylysine 14-25 CD47 molecule Homo sapiens 69-74 22613135-6 2012 We then compared biocompatibility between CD47B and CD47L functionalized polyvinyl chloride (PVC) surfaces and unmodified control PVC surfaces. Polyvinyl Chloride 73-91 CD47 molecule Homo sapiens 52-57 22613135-6 2012 We then compared biocompatibility between CD47B and CD47L functionalized polyvinyl chloride (PVC) surfaces and unmodified control PVC surfaces. Polyvinyl Chloride 93-96 CD47 molecule Homo sapiens 52-57 22448714-8 2012 RESULTS: Pre-operative surface expression of CD99 and CD47 correlates with post-operative creatinine levels (P < 0 05), a measurement of renal injury. Creatinine 90-100 CD47 molecule Homo sapiens 54-58 22215724-6 2012 Conversely, in hypoxic animals and cell cultures activation of CD47 by TSP1 disrupts this constitutive interaction, promoting eNOS-dependent superoxide production, oxidative stress, and PAH. Superoxides 141-151 CD47 molecule Homo sapiens 63-67 22215724-8 2012 Further, therapeutic blockade of CD47 activation in hypoxic pulmonary artery endothelial cells upregulated Cav-1, increased Cav-1CD47 co-association, decreased eNOS-derived superoxide, and protected animals from developing PAH. Superoxides 173-183 CD47 molecule Homo sapiens 33-37 22234309-6 2012 Dexamethasone-treated macrophages did also show enhanced phagocytosis of apoptotic thymocytes as well as unopsonized viable CD47(-/-) red blood cells, which was sensitive to inhibition by the LRP1-agonist RAP. Dexamethasone 0-13 CD47 molecule Homo sapiens 124-128 21429575-8 2011 Studies using human blood in an ex vivo flow-loop showed that CD47 modified PVC tubing significantly reduced cell binding and neutrophil activation compared to unmodified tubing or poly-2-methoxy-ethylacrylate (PMEA) coated tubing. poly(2-methoxyethylacrylate) 181-209 CD47 molecule Homo sapiens 62-66 21429575-8 2011 Studies using human blood in an ex vivo flow-loop showed that CD47 modified PVC tubing significantly reduced cell binding and neutrophil activation compared to unmodified tubing or poly-2-methoxy-ethylacrylate (PMEA) coated tubing. poly(2-methoxyethylacrylate) 211-215 CD47 molecule Homo sapiens 62-66 21401803-0 2011 A new disulfide-linked dimer of a single-chain antibody fragment against human CD47 induces apoptosis in lymphoid malignant cells via the hypoxia inducible factor-1alpha pathway. Disulfides 6-15 CD47 molecule Homo sapiens 79-83 21343308-7 2011 Mutagenesis identified glycosaminoglycan modification of CD47 at Ser(64) and Ser(79). Serine 65-68 CD47 molecule Homo sapiens 57-61 21054813-2 2011 The high predictive value of the eosin-5-maleimide (EMA)-binding test for the diagnosis of HS is because of its interaction with transmembrane proteins band 3, Rh protein, Rh glycoprotein and CD47, which are reduced on HS red cells. eosin maleimide 33-50 CD47 molecule Homo sapiens 192-196 21054813-2 2011 The high predictive value of the eosin-5-maleimide (EMA)-binding test for the diagnosis of HS is because of its interaction with transmembrane proteins band 3, Rh protein, Rh glycoprotein and CD47, which are reduced on HS red cells. eosin maleimide 52-55 CD47 molecule Homo sapiens 192-196 22130238-0 2011 Decreases in CD31 and CD47 levels on the cell surface during etoposide-induced Jurkat cell apoptosis. Etoposide 61-70 CD47 molecule Homo sapiens 22-26 20006665-3 2010 A method of affinity chromatography in the presence of high concentrations of Triton X-100, previously developed for identifying proteins associated with the TSP-1 receptor CD47, was utilized for the detection of C21 binding molecules and their detergent-resistant, associated partners. Octoxynol 78-90 CD47 molecule Homo sapiens 173-177 20538335-0 2010 CD47-dependent molecular mechanisms of blood outgrowth endothelial cell attachment on cholesterol-modified polyurethane. Cholesterol 86-97 CD47 molecule Homo sapiens 0-4 20538335-0 2010 CD47-dependent molecular mechanisms of blood outgrowth endothelial cell attachment on cholesterol-modified polyurethane. Polyurethanes 107-119 CD47 molecule Homo sapiens 0-4 20538335-3 2010 CD47, a multifunctional transmembrane glycoprotein involved in cellular attachment, can form a cholesterol-dependent complex with integrin alpha(v)beta(3) and heterotrimeric G proteins. Cholesterol 95-106 CD47 molecule Homo sapiens 0-4 20538335-4 2010 We tested herein the hypothesis that CD47, and the other components of the multi-molecular complex, enhance the attachment of BOECs to PU-Chol. pu-chol 135-142 CD47 molecule Homo sapiens 37-41 20538335-6 2010 The three-fold increase in BOEC attachment to PU-Chol, compared to unmodified PU, was reversed with the addition of blocking antibodies specific for CD47 and integrin alpha(v) and integrin beta(3). pu-chol 46-53 CD47 molecule Homo sapiens 149-153 20538335-7 2010 Similar results were observed with the addition of methyl-beta-cyclodextrin (MbetaCD), a known disruptor of the CD47 complex as well as of the membrane cholesterol content, to seeded BOEC or PU-Chol films. methyl-beta-cyclodextrin 51-75 CD47 molecule Homo sapiens 112-116 20538335-7 2010 Similar results were observed with the addition of methyl-beta-cyclodextrin (MbetaCD), a known disruptor of the CD47 complex as well as of the membrane cholesterol content, to seeded BOEC or PU-Chol films. methyl-beta-cyclodextrin 77-84 CD47 molecule Homo sapiens 112-116 20538335-8 2010 Reducing CD47 expression, via lentivirus transduced shRNA, decreased BOEC binding to PU-Chol by 50% compared to control groups. pu-chol 85-92 CD47 molecule Homo sapiens 9-13 20538335-9 2010 These data are the first demonstration of a role for the CD47 cholesterol-dependent signaling complex in BOEC attachment onto synthetic surfaces. Cholesterol 62-73 CD47 molecule Homo sapiens 57-61 22130238-4 2011 The CD31 and CD47 levels on the cell surface of apoptotic Jurkat cells had decreased after treatment with etoposide. Etoposide 106-115 CD47 molecule Homo sapiens 13-17 22130238-5 2011 These decreases in CD31 and CD47 levels on the apoptotic cell surface were almost completely suppressed by the caspase 3 inhibitor, Ac-DEVD-CHO, and partially suppressed by caspase 8 (Ac-IETD-CHO) and caspase 9 (Ac-LEHE-CHO) inhibitors but not by the metalloproteinase inhibitors GM6001 and TAPI-0. acetyl-aspartyl-glutamyl-valyl-aspartal 132-143 CD47 molecule Homo sapiens 28-32 22130238-5 2011 These decreases in CD31 and CD47 levels on the apoptotic cell surface were almost completely suppressed by the caspase 3 inhibitor, Ac-DEVD-CHO, and partially suppressed by caspase 8 (Ac-IETD-CHO) and caspase 9 (Ac-LEHE-CHO) inhibitors but not by the metalloproteinase inhibitors GM6001 and TAPI-0. Ac-IETD-CHO 184-195 CD47 molecule Homo sapiens 28-32 22130238-5 2011 These decreases in CD31 and CD47 levels on the apoptotic cell surface were almost completely suppressed by the caspase 3 inhibitor, Ac-DEVD-CHO, and partially suppressed by caspase 8 (Ac-IETD-CHO) and caspase 9 (Ac-LEHE-CHO) inhibitors but not by the metalloproteinase inhibitors GM6001 and TAPI-0. ac-lehe-cho 212-223 CD47 molecule Homo sapiens 28-32 22130238-5 2011 These decreases in CD31 and CD47 levels on the apoptotic cell surface were almost completely suppressed by the caspase 3 inhibitor, Ac-DEVD-CHO, and partially suppressed by caspase 8 (Ac-IETD-CHO) and caspase 9 (Ac-LEHE-CHO) inhibitors but not by the metalloproteinase inhibitors GM6001 and TAPI-0. N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide 280-286 CD47 molecule Homo sapiens 28-32 22130238-5 2011 These decreases in CD31 and CD47 levels on the apoptotic cell surface were almost completely suppressed by the caspase 3 inhibitor, Ac-DEVD-CHO, and partially suppressed by caspase 8 (Ac-IETD-CHO) and caspase 9 (Ac-LEHE-CHO) inhibitors but not by the metalloproteinase inhibitors GM6001 and TAPI-0. TAPI-0 291-297 CD47 molecule Homo sapiens 28-32 20923780-8 2010 These results reveal that anti-angiogenic signaling through CD47 is highly redundant and extends beyond inhibition of nitric oxide signaling to global inhibition of VEGFR2 signaling. Nitric Oxide 118-130 CD47 molecule Homo sapiens 60-64 20959404-1 2010 PURPOSE: Inhibitors of antiapoptosis protein (IAP) have been implicated in the resistance to cisplatin. Cisplatin 93-102 CD47 molecule Homo sapiens 9-44 20959404-1 2010 PURPOSE: Inhibitors of antiapoptosis protein (IAP) have been implicated in the resistance to cisplatin. Cisplatin 93-102 CD47 molecule Homo sapiens 46-49 19143843-6 2009 At a later time point (24 h), opsonized zymosan was found to induce increased expression of CD47 adhesion molecule, platelet aggregation, mitochondrial membrane depolarization and phosphatidylserine externalization. Zymosan 40-47 CD47 molecule Homo sapiens 92-96 19481167-7 2009 We hypothesized that nitrite would provide an ischemic NO source that could be potentiated by TSP1-CD47 blockade enhancing ischemic tissue survival, blood flow and angiogenesis. Nitrites 21-28 CD47 molecule Homo sapiens 99-103 19481167-13 2009 These data provide a new therapeutic paradigm for hypoxic NO signaling through enhanced cGMP mediated by TSP1-CD47 blockade and nitrite delivery. Cyclic GMP 88-92 CD47 molecule Homo sapiens 110-114 19162043-7 2009 We found that the induction of ALP, type I collagen, osteocalcin, CD44, CD47 and CD51 by mevinolin is responsible for the osteoblastic differentiation of D1 cells. Lovastatin 89-98 CD47 molecule Homo sapiens 72-76 20161613-4 2009 A morpholino oligonucleotide targeting CD47 confers radioresistance to human endothelial cells in vitro and protects soft tissue, bone marrow, and tumor-associated leukocytes in irradiated mice. Morpholinos 2-28 CD47 molecule Homo sapiens 39-43 19162043-0 2009 Mevinolin enhances osteogenic genes (ALP, type I collagen and osteocalcin), CD44, CD47 and CD51 expression during osteogenic differentiation. Lovastatin 0-9 CD47 molecule Homo sapiens 82-86 18187671-3 2008 The recent discovery that thrombospondin-1 acts via CD47 to inhibit nitric oxide signaling throughout the vascular system has given new importance and perhaps a unifying mechanism of action to these enigmatic proteins. Nitric Oxide 68-80 CD47 molecule Homo sapiens 52-56 18292237-0 2008 Glucose regulation of integrin-associated protein cleavage controls the response of vascular smooth muscle cells to insulin-like growth factor-I. Glucose 0-7 CD47 molecule Homo sapiens 22-49 18292237-4 2008 The association of integrin-associated protein (IAP) with SHPS-1 is required for SHPS-1 tyrosine phosphorylation. Tyrosine 88-96 CD47 molecule Homo sapiens 19-46 18292237-4 2008 The association of integrin-associated protein (IAP) with SHPS-1 is required for SHPS-1 tyrosine phosphorylation. Tyrosine 88-96 CD47 molecule Homo sapiens 48-51 18292237-5 2008 When SMC were grown in 5 mm glucose, the amount of intact IAP was reduced, compared with SMC grown in 25 mm glucose. Glucose 28-35 CD47 molecule Homo sapiens 58-61 18292237-11 2008 Our results show that the enhanced response of SMC in 25 mm glucose to IGF-I is due to the protection of IAP from proteolytic degradation, thereby increasing its association with SHPS-1 and allowing the formation of the SHPS-1-Shc signaling complex. Glucose 60-67 CD47 molecule Homo sapiens 105-108 18332220-4 2008 When CD47 is functional, the macrophage counter-receptor and phosphatase-activator SIRPalpha localizes to the synapse, suppressing accumulation of phosphotyrosine and myosin without affecting F-actin. Phosphotyrosine 147-162 CD47 molecule Homo sapiens 5-9 18428041-0 2008 Patching of ganglioside(M1) in human erythrocytes - distribution of CD47 and CD59 in patched and curved membrane. Gangliosides 12-23 CD47 molecule Homo sapiens 68-72 18428041-3 2008 We have studied by fluorescence microscopy cross-linking of ganglioside GM1 in the human erythrocyte membrane, and how membrane proteins CD47 and CD59 distribute in GM1 patched discoid cells and calcium-induced echinocytic cells. G(M1) Ganglioside 165-168 CD47 molecule Homo sapiens 137-141 18428041-3 2008 We have studied by fluorescence microscopy cross-linking of ganglioside GM1 in the human erythrocyte membrane, and how membrane proteins CD47 and CD59 distribute in GM1 patched discoid cells and calcium-induced echinocytic cells. Calcium 195-202 CD47 molecule Homo sapiens 137-141 18332220-6 2008 CD47-SIRPalpha interaction initiates a dephosphorylation cascade directed in part at phosphotyrosine in myosin. Phosphotyrosine 85-100 CD47 molecule Homo sapiens 0-4 16847352-3 2006 Decrease of Txr1 or treatment with TSP-1 or TSP-1 mimetic peptide sensitized cells to taxane cytotoxicity by activating signaling through the CD47 receptor (also known as the integrin-associated protein), whereas interference with CD47 function reduced taxane-induced cell death. taxane 86-92 CD47 molecule Homo sapiens 142-146 18186923-9 2008 The function-blocking anti-CD47/IAP antibody Bric 126 inhibited changes in membrane potential, tyrosine phosphorylation, and elevation of relative levels of aggrecan mRNA induced by mechanical stimulation, whereas in the presence of B6H12, an antibody that has partial agonist activity, a membrane depolarisation rather than a membrane hyperpolarisation response was induced by mechanical stimulation. Tyrosine 95-103 CD47 molecule Homo sapiens 32-35 18186923-9 2008 The function-blocking anti-CD47/IAP antibody Bric 126 inhibited changes in membrane potential, tyrosine phosphorylation, and elevation of relative levels of aggrecan mRNA induced by mechanical stimulation, whereas in the presence of B6H12, an antibody that has partial agonist activity, a membrane depolarisation rather than a membrane hyperpolarisation response was induced by mechanical stimulation. b6h12 233-238 CD47 molecule Homo sapiens 27-31 18836230-6 2008 Mechanical stimulation of normal chondrocytes resulted in increased GAG synthesis that was blocked by the presence of antibodies to alpha5 and alphaVbeta5 integrins and CD47. Glycosaminoglycans 68-71 CD47 molecule Homo sapiens 169-173 18207024-2 2008 We previously showed that tyrosine phosphorylation might serve as the downstream signaling for the modulation of PMN transmigration by CD47. Tyrosine 26-34 CD47 molecule Homo sapiens 135-139 18207024-10 2008 Treatment with PP1, PP2 or piceatannol all partially reversed the delay of PMN transmigration caused by inhibitory anti-CD47 antibody. 3,3',4,5'-tetrahydroxystilbene 27-38 CD47 molecule Homo sapiens 120-124 16962673-0 2006 The C-terminal CD47/IAP-binding domain of thrombospondin-1 prevents camptothecin- and doxorubicin-induced apoptosis in human thyroid carcinoma cells. Camptothecin 68-80 CD47 molecule Homo sapiens 15-19 16962673-0 2006 The C-terminal CD47/IAP-binding domain of thrombospondin-1 prevents camptothecin- and doxorubicin-induced apoptosis in human thyroid carcinoma cells. Camptothecin 68-80 CD47 molecule Homo sapiens 20-23 16962673-0 2006 The C-terminal CD47/IAP-binding domain of thrombospondin-1 prevents camptothecin- and doxorubicin-induced apoptosis in human thyroid carcinoma cells. Doxorubicin 86-97 CD47 molecule Homo sapiens 15-19 16962673-0 2006 The C-terminal CD47/IAP-binding domain of thrombospondin-1 prevents camptothecin- and doxorubicin-induced apoptosis in human thyroid carcinoma cells. Doxorubicin 86-97 CD47 molecule Homo sapiens 20-23 18193160-5 2008 Thrombospondin-1 binding to CD47 inhibits NO signaling by preventing cGMP synthesis and activation of its target cGMP-dependent protein kinase. Cyclic GMP 69-73 CD47 molecule Homo sapiens 28-32 18186923-9 2008 The function-blocking anti-CD47/IAP antibody Bric 126 inhibited changes in membrane potential, tyrosine phosphorylation, and elevation of relative levels of aggrecan mRNA induced by mechanical stimulation, whereas in the presence of B6H12, an antibody that has partial agonist activity, a membrane depolarisation rather than a membrane hyperpolarisation response was induced by mechanical stimulation. Tyrosine 95-103 CD47 molecule Homo sapiens 27-31 16847352-3 2006 Decrease of Txr1 or treatment with TSP-1 or TSP-1 mimetic peptide sensitized cells to taxane cytotoxicity by activating signaling through the CD47 receptor (also known as the integrin-associated protein), whereas interference with CD47 function reduced taxane-induced cell death. taxane 86-92 CD47 molecule Homo sapiens 175-202 16847352-3 2006 Decrease of Txr1 or treatment with TSP-1 or TSP-1 mimetic peptide sensitized cells to taxane cytotoxicity by activating signaling through the CD47 receptor (also known as the integrin-associated protein), whereas interference with CD47 function reduced taxane-induced cell death. taxane 253-259 CD47 molecule Homo sapiens 142-146 16161151-4 2006 CD47 has multiple sites of glycosylation and a core disulfide bond. Disulfides 52-61 CD47 molecule Homo sapiens 0-4 16161151-7 2006 Site-by-site mutagenesis of CD47"s five N-linked glycosylation sites progressively decreases expression levels on yeast, but folding appears stable. Nitrogen 40-41 CD47 molecule Homo sapiens 28-32 15784688-5 2005 In patients with SM, MC also reacted with antibodies against SIRPalpha and CD47. Methylcholanthrene 21-23 CD47 molecule Homo sapiens 75-79 15917238-0 2005 CD47 augments Fas/CD95-mediated apoptosis. ammonium ferrous sulfate 14-17 CD47 molecule Homo sapiens 0-4 15917238-2 2005 Jurkat T cells lacking CD47 (integrin-associated protein) are relatively resistant to Fas-mediated death but are efficiently killed by Fas ligand or anti-Fas IgM (CH11) upon expression of CD47. ammonium ferrous sulfate 86-89 CD47 molecule Homo sapiens 23-27 15917238-2 2005 Jurkat T cells lacking CD47 (integrin-associated protein) are relatively resistant to Fas-mediated death but are efficiently killed by Fas ligand or anti-Fas IgM (CH11) upon expression of CD47. ammonium ferrous sulfate 86-89 CD47 molecule Homo sapiens 29-56 15917238-5 2005 CH11 induces association of Fas and CD47. 4-dimethylamino-3',4'-dimethoxychalcone 0-4 CD47 molecule Homo sapiens 36-40 15917238-5 2005 CH11 induces association of Fas and CD47. ammonium ferrous sulfate 28-31 CD47 molecule Homo sapiens 36-40 15917238-7 2005 Thus CD47 associates with Fas upon its activation and augments Fas-mediated apoptosis. ammonium ferrous sulfate 26-29 CD47 molecule Homo sapiens 5-9 15917238-7 2005 Thus CD47 associates with Fas upon its activation and augments Fas-mediated apoptosis. ammonium ferrous sulfate 63-66 CD47 molecule Homo sapiens 5-9 16118322-4 2005 The release of TSP-1 by DCs in response to ATP was confirmed at the protein level by enzyme-linked immunosorbent assay (ELISA), immunodetection, and mass spectrometry analysis, and has an antiproliferative effect on T CD4+ lymphocytes through TSP-1/CD47 interaction. Adenosine Triphosphate 43-46 CD47 molecule Homo sapiens 249-253 16166298-0 2005 Disruption of the inhibitor of apoptosis protein survivin sensitizes Bcr-abl-positive cells to STI571-induced apoptosis. Imatinib Mesylate 95-101 CD47 molecule Homo sapiens 18-48 15784688-10 2005 In summary, our data show that MC express functional SIRPalpha and CD47 in SM, whereas expression of SHP-1 varies among donors and is low compared with LMC. Methylcholanthrene 31-33 CD47 molecule Homo sapiens 67-71 15292185-8 2004 CD47 signaling in SS RBCs appears to be independent of large scale changes in cAMP formation but nonetheless promotes alpha4beta1-mediated adhesion via a protein kinase A-dependent, serine phosphorylation of the alpha4 cytoplasmic domain. Serine 182-188 CD47 molecule Homo sapiens 0-4 15292185-9 2004 CD47-activated SS RBC adhesion absolutely requires the Src family tyrosine kinases and is also enhanced by treatment of SS RBCs with low concentrations of cytochalasin D, which may release alpha4beta1 from cytoskeletal restraints. Cytochalasin D 155-169 CD47 molecule Homo sapiens 0-4 15297459-7 2004 After down-regulation of the endogenous IAP by small interfering RNA, MAPK activity, synaptic protein levels, and glutamate release decreased. Glutamic Acid 114-123 CD47 molecule Homo sapiens 40-43 14871834-9 2004 Forskolin, 8-bromo cAMP, and isobutylmethylxanthine (IBMX) all prevented CD47-mediated apoptosis, indicating the involvement of cAMP. Colforsin 0-9 CD47 molecule Homo sapiens 73-77 15330258-6 2004 In addition, this linkage group contains several CDs important for the immune system CD166, CD47 and many members of the tetraspanin family. Cadmium 49-52 CD47 molecule Homo sapiens 92-96 14871834-9 2004 Forskolin, 8-bromo cAMP, and isobutylmethylxanthine (IBMX) all prevented CD47-mediated apoptosis, indicating the involvement of cAMP. 8-Bromo Cyclic Adenosine Monophosphate 11-23 CD47 molecule Homo sapiens 73-77 14871834-9 2004 Forskolin, 8-bromo cAMP, and isobutylmethylxanthine (IBMX) all prevented CD47-mediated apoptosis, indicating the involvement of cAMP. 1-Methyl-3-isobutylxanthine 29-51 CD47 molecule Homo sapiens 73-77 14871834-9 2004 Forskolin, 8-bromo cAMP, and isobutylmethylxanthine (IBMX) all prevented CD47-mediated apoptosis, indicating the involvement of cAMP. 1-Methyl-3-isobutylxanthine 53-57 CD47 molecule Homo sapiens 73-77 14871834-9 2004 Forskolin, 8-bromo cAMP, and isobutylmethylxanthine (IBMX) all prevented CD47-mediated apoptosis, indicating the involvement of cAMP. Cyclic AMP 19-23 CD47 molecule Homo sapiens 73-77 14871834-12 2004 Thus, CD47-mediated killing of breast cancer cells occurs by a novel pathway involving regulation of cAMP levels by heterotrimeric Gi with subsequent effects mediated by PKA. Cyclic AMP 101-105 CD47 molecule Homo sapiens 6-10 14720372-1 2004 BACKGROUND & OBJECTIVE: Survivin, a member of the inhibitor of apoptosis protein (IAP) family, can directly inhibit caspase-3 and caspase-7 activity and plays an important role in oncogenesis. Adenosine Monophosphate 12-15 CD47 molecule Homo sapiens 54-84 14720372-1 2004 BACKGROUND & OBJECTIVE: Survivin, a member of the inhibitor of apoptosis protein (IAP) family, can directly inhibit caspase-3 and caspase-7 activity and plays an important role in oncogenesis. Adenosine Monophosphate 12-15 CD47 molecule Homo sapiens 86-89 12351399-8 2002 Cytochalasin D, an inhibitor of actin polymerization, and antimycin A, an inhibitor of mitochondrial electron transfer, completely suppressed CD47-induced phosphatidylserine exposure. Cytochalasin D 0-14 CD47 molecule Homo sapiens 142-146 14585540-0 2003 Mitochondrial dysfunction in CD47-mediated caspase-independent cell death: ROS production in the absence of cytochrome c and AIF release. Reactive Oxygen Species 75-78 CD47 molecule Homo sapiens 29-33 14585540-4 2003 After T cell stimulation via CD47, a rapid mitochondrial transmembrane potential (deltapsi(m)) disruption is accompanied by the production of reactive oxygen species (ROS) and phosphatidylserine exposure. Reactive Oxygen Species 142-165 CD47 molecule Homo sapiens 29-33 14585540-4 2003 After T cell stimulation via CD47, a rapid mitochondrial transmembrane potential (deltapsi(m)) disruption is accompanied by the production of reactive oxygen species (ROS) and phosphatidylserine exposure. Reactive Oxygen Species 167-170 CD47 molecule Homo sapiens 29-33 14585540-7 2003 We conclude that DeltaPsi(m) loss and ROS production are an early step in CD47-dependent killing and neither cytochrome c, nor AIF are implicated in this new cell death pathway. Reactive Oxygen Species 38-41 CD47 molecule Homo sapiens 74-78 12646616-7 2003 Pretreatment of T cells with 8-bromo cAMP, forskolin, or 3-isobutyl-1-methylxanthine prevented the CD47-mediated apoptosis, and 1F7 dramatically reduced intracellular cAMP levels, an effect reversed with PTX. 8-Bromo Cyclic Adenosine Monophosphate 29-41 CD47 molecule Homo sapiens 99-103 12646616-7 2003 Pretreatment of T cells with 8-bromo cAMP, forskolin, or 3-isobutyl-1-methylxanthine prevented the CD47-mediated apoptosis, and 1F7 dramatically reduced intracellular cAMP levels, an effect reversed with PTX. Colforsin 43-52 CD47 molecule Homo sapiens 99-103 12646616-7 2003 Pretreatment of T cells with 8-bromo cAMP, forskolin, or 3-isobutyl-1-methylxanthine prevented the CD47-mediated apoptosis, and 1F7 dramatically reduced intracellular cAMP levels, an effect reversed with PTX. 1-Methyl-3-isobutylxanthine 57-84 CD47 molecule Homo sapiens 99-103 12646616-7 2003 Pretreatment of T cells with 8-bromo cAMP, forskolin, or 3-isobutyl-1-methylxanthine prevented the CD47-mediated apoptosis, and 1F7 dramatically reduced intracellular cAMP levels, an effect reversed with PTX. Cyclic AMP 37-41 CD47 molecule Homo sapiens 99-103 12646616-9 2003 Thus, CD47-mediated killing of activated T cells occurs by a novel pathway involving regulation of cAMP levels by heterotrimeric G((i)alpha) with subsequent effects mediated by PKA. Cyclic AMP 99-103 CD47 molecule Homo sapiens 6-10 12464013-2 2002 Previous work has shown that an FHA Arg-Gly-Asp (RGD, residues 1097-1099) site interacts with a complex composed of leucocyte response integrin (LRI, alphavbeta3 integrin) and integrin-associated protein (IAP, CD47) on human monocytes, resulting in enhancement of CR3-mediated bacterial binding. Arginine 36-39 CD47 molecule Homo sapiens 116-203 12464013-2 2002 Previous work has shown that an FHA Arg-Gly-Asp (RGD, residues 1097-1099) site interacts with a complex composed of leucocyte response integrin (LRI, alphavbeta3 integrin) and integrin-associated protein (IAP, CD47) on human monocytes, resulting in enhancement of CR3-mediated bacterial binding. Arginine 36-39 CD47 molecule Homo sapiens 205-208 12464013-2 2002 Previous work has shown that an FHA Arg-Gly-Asp (RGD, residues 1097-1099) site interacts with a complex composed of leucocyte response integrin (LRI, alphavbeta3 integrin) and integrin-associated protein (IAP, CD47) on human monocytes, resulting in enhancement of CR3-mediated bacterial binding. Arginine 36-39 CD47 molecule Homo sapiens 210-214 12464013-2 2002 Previous work has shown that an FHA Arg-Gly-Asp (RGD, residues 1097-1099) site interacts with a complex composed of leucocyte response integrin (LRI, alphavbeta3 integrin) and integrin-associated protein (IAP, CD47) on human monocytes, resulting in enhancement of CR3-mediated bacterial binding. Glycine 40-43 CD47 molecule Homo sapiens 116-203 12464013-2 2002 Previous work has shown that an FHA Arg-Gly-Asp (RGD, residues 1097-1099) site interacts with a complex composed of leucocyte response integrin (LRI, alphavbeta3 integrin) and integrin-associated protein (IAP, CD47) on human monocytes, resulting in enhancement of CR3-mediated bacterial binding. Glycine 40-43 CD47 molecule Homo sapiens 205-208 12464013-2 2002 Previous work has shown that an FHA Arg-Gly-Asp (RGD, residues 1097-1099) site interacts with a complex composed of leucocyte response integrin (LRI, alphavbeta3 integrin) and integrin-associated protein (IAP, CD47) on human monocytes, resulting in enhancement of CR3-mediated bacterial binding. Glycine 40-43 CD47 molecule Homo sapiens 210-214 12464013-2 2002 Previous work has shown that an FHA Arg-Gly-Asp (RGD, residues 1097-1099) site interacts with a complex composed of leucocyte response integrin (LRI, alphavbeta3 integrin) and integrin-associated protein (IAP, CD47) on human monocytes, resulting in enhancement of CR3-mediated bacterial binding. Aspartic Acid 44-47 CD47 molecule Homo sapiens 116-203 12464013-2 2002 Previous work has shown that an FHA Arg-Gly-Asp (RGD, residues 1097-1099) site interacts with a complex composed of leucocyte response integrin (LRI, alphavbeta3 integrin) and integrin-associated protein (IAP, CD47) on human monocytes, resulting in enhancement of CR3-mediated bacterial binding. Aspartic Acid 44-47 CD47 molecule Homo sapiens 205-208 12464013-2 2002 Previous work has shown that an FHA Arg-Gly-Asp (RGD, residues 1097-1099) site interacts with a complex composed of leucocyte response integrin (LRI, alphavbeta3 integrin) and integrin-associated protein (IAP, CD47) on human monocytes, resulting in enhancement of CR3-mediated bacterial binding. Aspartic Acid 44-47 CD47 molecule Homo sapiens 210-214 12464013-5 2002 Wortmannin and LY294002, inhibitors of PI3-K, reduced alphavbeta3/IAP-upregulated, CR3-associated bacterial binding to human monocytes. Wortmannin 0-10 CD47 molecule Homo sapiens 66-69 12464013-5 2002 Wortmannin and LY294002, inhibitors of PI3-K, reduced alphavbeta3/IAP-upregulated, CR3-associated bacterial binding to human monocytes. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 15-23 CD47 molecule Homo sapiens 66-69 12464013-7 2002 In contrast, cells infected with an isogenic strain carrying a G1098A mutation at the FHA RGD site did not show any recruitment of PI3-K. We found that ligation of FHA by alphavbeta3/IAP induced RGD-dependent tyrosine phosphorylation of a 60 kDa protein, which associated with IAP and PI3-K in human monocytes. Tyrosine 209-217 CD47 molecule Homo sapiens 183-186 12218055-8 2002 CD47-independent activation of alpha4beta1 required the Val-Val-Met (VVM) motif of the peptides and was sensitive to inhibition by pertussis toxin. Val-Val-Met 56-67 CD47 molecule Homo sapiens 0-4 12351399-8 2002 Cytochalasin D, an inhibitor of actin polymerization, and antimycin A, an inhibitor of mitochondrial electron transfer, completely suppressed CD47-induced phosphatidylserine exposure. Antimycin A 58-69 CD47 molecule Homo sapiens 142-146 12153520-10 2002 BRIC126 antibody inhibited the binding of platelets and of CD47-transfected cells to human TSP and to pig fibrinogen, whereas no effect was observed on control CHO cells. bric126 0-7 CD47 molecule Homo sapiens 59-63 11454874-0 2001 Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains. Disulfides 96-105 CD47 molecule Homo sapiens 39-43 11479293-3 2001 Here we show that anti-CD47 monoclonal antibodies (mAbs) delay PMN migration across collagen-coated filters or T84 epithelial monolayers toward the chemoattractant formylmethionylleucylphenylalanine (fMLP). N-Formylmethionine Leucyl-Phenylalanine 164-198 CD47 molecule Homo sapiens 23-27 11479293-7 2001 Experiments performed to investigate potential signaling pathways revealed that inhibition of tyrosine phosphorylation with genistein reversed the anti-CD47-mediated PMN migration delay, whereas inhibition of phosphatidylinositol 3-kinase only partially reversed anti-CD47 effects that correlated with a rapid increase in PMN cell surface CD47. Tyrosine 94-102 CD47 molecule Homo sapiens 152-156 11479293-7 2001 Experiments performed to investigate potential signaling pathways revealed that inhibition of tyrosine phosphorylation with genistein reversed the anti-CD47-mediated PMN migration delay, whereas inhibition of phosphatidylinositol 3-kinase only partially reversed anti-CD47 effects that correlated with a rapid increase in PMN cell surface CD47. Genistein 124-133 CD47 molecule Homo sapiens 152-156 11479293-8 2001 Analysis of the contribution of epithelial-expressed CD47 to PMN transmigration revealed that PMN migration across CD47-deficient epithelial monolayers (CaCO2) was significantly increased after stable transfection with CD47. caco2 153-158 CD47 molecule Homo sapiens 53-57 11479293-8 2001 Analysis of the contribution of epithelial-expressed CD47 to PMN transmigration revealed that PMN migration across CD47-deficient epithelial monolayers (CaCO2) was significantly increased after stable transfection with CD47. caco2 153-158 CD47 molecule Homo sapiens 115-119 11479293-8 2001 Analysis of the contribution of epithelial-expressed CD47 to PMN transmigration revealed that PMN migration across CD47-deficient epithelial monolayers (CaCO2) was significantly increased after stable transfection with CD47. caco2 153-158 CD47 molecule Homo sapiens 115-119 11719373-1 2001 A peptide from the C-terminal domain of thrombospondin-1 (Arg-Phe-Tyr-Val-Val-Met-Trp-Lys; known as 4N1-1) has been reported to induce platelet aggregation and to bind to the integrin-associated protein (IAP), which is also known as CD47. Arginine 58-61 CD47 molecule Homo sapiens 175-202 11719373-1 2001 A peptide from the C-terminal domain of thrombospondin-1 (Arg-Phe-Tyr-Val-Val-Met-Trp-Lys; known as 4N1-1) has been reported to induce platelet aggregation and to bind to the integrin-associated protein (IAP), which is also known as CD47. Arginine 58-61 CD47 molecule Homo sapiens 204-207 11719373-1 2001 A peptide from the C-terminal domain of thrombospondin-1 (Arg-Phe-Tyr-Val-Val-Met-Trp-Lys; known as 4N1-1) has been reported to induce platelet aggregation and to bind to the integrin-associated protein (IAP), which is also known as CD47. Arginine 58-61 CD47 molecule Homo sapiens 233-237 11719373-1 2001 A peptide from the C-terminal domain of thrombospondin-1 (Arg-Phe-Tyr-Val-Val-Met-Trp-Lys; known as 4N1-1) has been reported to induce platelet aggregation and to bind to the integrin-associated protein (IAP), which is also known as CD47. phe-tyr-val-val-met-trp 62-85 CD47 molecule Homo sapiens 175-202 11719373-1 2001 A peptide from the C-terminal domain of thrombospondin-1 (Arg-Phe-Tyr-Val-Val-Met-Trp-Lys; known as 4N1-1) has been reported to induce platelet aggregation and to bind to the integrin-associated protein (IAP), which is also known as CD47. phe-tyr-val-val-met-trp 62-85 CD47 molecule Homo sapiens 204-207 11719373-1 2001 A peptide from the C-terminal domain of thrombospondin-1 (Arg-Phe-Tyr-Val-Val-Met-Trp-Lys; known as 4N1-1) has been reported to induce platelet aggregation and to bind to the integrin-associated protein (IAP), which is also known as CD47. phe-tyr-val-val-met-trp 62-85 CD47 molecule Homo sapiens 233-237 11719373-1 2001 A peptide from the C-terminal domain of thrombospondin-1 (Arg-Phe-Tyr-Val-Val-Met-Trp-Lys; known as 4N1-1) has been reported to induce platelet aggregation and to bind to the integrin-associated protein (IAP), which is also known as CD47. Lysine 86-89 CD47 molecule Homo sapiens 175-202 11719373-1 2001 A peptide from the C-terminal domain of thrombospondin-1 (Arg-Phe-Tyr-Val-Val-Met-Trp-Lys; known as 4N1-1) has been reported to induce platelet aggregation and to bind to the integrin-associated protein (IAP), which is also known as CD47. Lysine 86-89 CD47 molecule Homo sapiens 204-207 11719373-1 2001 A peptide from the C-terminal domain of thrombospondin-1 (Arg-Phe-Tyr-Val-Val-Met-Trp-Lys; known as 4N1-1) has been reported to induce platelet aggregation and to bind to the integrin-associated protein (IAP), which is also known as CD47. Lysine 86-89 CD47 molecule Homo sapiens 233-237 11454874-0 2001 Normal ligand binding and signaling by CD47 (integrin-associated protein) requires a long range disulfide bond between the extracellular and membrane-spanning domains. Disulfides 96-105 CD47 molecule Homo sapiens 45-72 11454874-3 2001 Conservation of Cys residues among CD47 homologues suggested the existence of a disulfide bond between the Ig and MMS domains that was confirmed by chemical digestion and mapped to Cys(33) and Cys(263). Cysteine 16-19 CD47 molecule Homo sapiens 35-39 11454874-3 2001 Conservation of Cys residues among CD47 homologues suggested the existence of a disulfide bond between the Ig and MMS domains that was confirmed by chemical digestion and mapped to Cys(33) and Cys(263). Disulfides 80-89 CD47 molecule Homo sapiens 35-39 11454874-3 2001 Conservation of Cys residues among CD47 homologues suggested the existence of a disulfide bond between the Ig and MMS domains that was confirmed by chemical digestion and mapped to Cys(33) and Cys(263). Cysteine 181-184 CD47 molecule Homo sapiens 35-39 11454874-3 2001 Conservation of Cys residues among CD47 homologues suggested the existence of a disulfide bond between the Ig and MMS domains that was confirmed by chemical digestion and mapped to Cys(33) and Cys(263). Cysteine 181-184 CD47 molecule Homo sapiens 35-39 11454874-5 2001 Mutagenesis to prevent formation of this disulfide completely disrupted CD47 signaling independent of effects on ligand binding, as assessed by T cell interleukin-2 secretion and Ca(2+) responses. Disulfides 41-50 CD47 molecule Homo sapiens 72-76 11454874-7 2001 Thus, a disulfide bond between the Ig and MMS domains of CD47 is required for normal ligand binding and signal transduction. Disulfides 8-17 CD47 molecule Homo sapiens 57-61 11509594-3 2001 In this study, we first show that CD47/integrin-associated protein, a ubiquitous multispan transmembrane protein highly expressed on T cells, interacts with signal-regulator protein (SIRP)-alpha, an immunoreceptor tyrosine-based inhibition motif-containing molecule selectively expressed on myelomonocytic cells, and next demonstrate that this pair of molecules negatively regulates human T and dendritic cell (DC) function. Tyrosine 214-222 CD47 molecule Homo sapiens 34-38 11509594-3 2001 In this study, we first show that CD47/integrin-associated protein, a ubiquitous multispan transmembrane protein highly expressed on T cells, interacts with signal-regulator protein (SIRP)-alpha, an immunoreceptor tyrosine-based inhibition motif-containing molecule selectively expressed on myelomonocytic cells, and next demonstrate that this pair of molecules negatively regulates human T and dendritic cell (DC) function. Tyrosine 214-222 CD47 molecule Homo sapiens 39-66 11134570-9 2000 Diamide-treated RBCs exposed to serum bound opsonin much as did senescent RBCs, and sequestration was inhibited by GalNAc, RGD, and antibodies to CR3, FcgammaRI, FcgammaRII, LRI, and IAP. Diamide 0-7 CD47 molecule Homo sapiens 183-186 11156950-1 2001 Integrin-associated protein (CD47/IAP) is a pentaspan molecule that regulates integrin functions. Hydroxyethyl Starch Derivatives 44-53 CD47 molecule Homo sapiens 0-27 11156950-1 2001 Integrin-associated protein (CD47/IAP) is a pentaspan molecule that regulates integrin functions. Hydroxyethyl Starch Derivatives 44-53 CD47 molecule Homo sapiens 29-33 11156950-1 2001 Integrin-associated protein (CD47/IAP) is a pentaspan molecule that regulates integrin functions. Hydroxyethyl Starch Derivatives 44-53 CD47 molecule Homo sapiens 34-37 11114301-4 2001 Disruption of membrane rafts by removal of cholesterol with cyclodextrin blocked CD47-induced actin polymerization, and mutant forms of CD47 that localized poorly to rafts failed to effect cytoskeletal rearrangement. Cholesterol 43-54 CD47 molecule Homo sapiens 81-85 11114301-4 2001 Disruption of membrane rafts by removal of cholesterol with cyclodextrin blocked CD47-induced actin polymerization, and mutant forms of CD47 that localized poorly to rafts failed to effect cytoskeletal rearrangement. Cyclodextrins 60-72 CD47 molecule Homo sapiens 81-85 11114301-5 2001 However, raft association alone was not sufficient, because a raft-localized CD47 Ig domain bound to the membrane by a glycan phosphoinositol anchor was unable to induce actin polymerization. glycan phosphoinositol 119-141 CD47 molecule Homo sapiens 77-81 11114301-6 2001 A mutant form of CD47 without its Ig domain that did not induce actin polymerization or localize to rafts still enhanced T cell receptor (TCR)-dependent tyrosine phosphorylation of PLCgamma and associated Ca(2+) signaling but did not augment IL-2 secretion. Tyrosine 153-161 CD47 molecule Homo sapiens 17-21 11306274-1 2001 Integrin-associated protein (IAP or CD47) is a receptor for thrombospondin family members, a ligand for the transmembrane signaling protein SIRP alpha and a component of a supramolecular complex containing specific integrins, heterotrimeric G proteins and cholesterol. Cholesterol 256-267 CD47 molecule Homo sapiens 0-27 11306274-1 2001 Integrin-associated protein (IAP or CD47) is a receptor for thrombospondin family members, a ligand for the transmembrane signaling protein SIRP alpha and a component of a supramolecular complex containing specific integrins, heterotrimeric G proteins and cholesterol. Cholesterol 256-267 CD47 molecule Homo sapiens 29-32 11306274-1 2001 Integrin-associated protein (IAP or CD47) is a receptor for thrombospondin family members, a ligand for the transmembrane signaling protein SIRP alpha and a component of a supramolecular complex containing specific integrins, heterotrimeric G proteins and cholesterol. Cholesterol 256-267 CD47 molecule Homo sapiens 36-40 10493512-12 1999 Furthermore, cells treated with CD47/IAP- or the alpha(v)beta3 integrin-reactive antibodies prevented the alpha3(IV)185-203 peptide from inhibiting cell proliferation and the subsequent rise in intracellular cAMP. Cyclic AMP 208-212 CD47 molecule Homo sapiens 32-36 10994154-1 2000 Two series of 6-substituted benzimidazo[1,2-c]quinazolines (Ia-p and IIa-l) have been synthesized and characterized. 6-substituted benzimidazo[1,2-c]quinazolines 14-58 CD47 molecule Homo sapiens 60-64 11034562-5 2000 The anti-CDw149 mAbs bind with only low affinity to a monomeric (unclustered) subset of CD47 but with high avidity to the CD47 clusters. cdw149 9-15 CD47 molecule Homo sapiens 88-92 11034562-5 2000 The anti-CDw149 mAbs bind with only low affinity to a monomeric (unclustered) subset of CD47 but with high avidity to the CD47 clusters. cdw149 9-15 CD47 molecule Homo sapiens 122-126 10525543-11 1999 In agreement with this, 4N1K evoked a rapid decrease in cAMP levels which was intensified in the presence of collagen, and forskolin and 8-Br-cAMP both inhibited SMC migration stimulated via IAP. Colforsin 123-132 CD47 molecule Homo sapiens 191-194 10525543-11 1999 In agreement with this, 4N1K evoked a rapid decrease in cAMP levels which was intensified in the presence of collagen, and forskolin and 8-Br-cAMP both inhibited SMC migration stimulated via IAP. 8-Bromo Cyclic Adenosine Monophosphate 137-146 CD47 molecule Homo sapiens 191-194 10525543-15 1999 Thus, IAP stimulates alpha2beta1 integrin-mediated SMC migration via Gi-mediated inhibition of ERK activity and suppression of cyclic AMP levels. Cyclic AMP 127-137 CD47 molecule Homo sapiens 6-9 10493512-12 1999 Furthermore, cells treated with CD47/IAP- or the alpha(v)beta3 integrin-reactive antibodies prevented the alpha3(IV)185-203 peptide from inhibiting cell proliferation and the subsequent rise in intracellular cAMP. Cyclic AMP 208-212 CD47 molecule Homo sapiens 37-40 7998989-7 1994 CD47 has six potential N-glycosylation sites, five of which are in an Ig superfamily domain. Nitrogen 23-24 CD47 molecule Homo sapiens 0-4 10444074-0 1999 Role of cholesterol in formation and function of a signaling complex involving alphavbeta3, integrin-associated protein (CD47), and heterotrimeric G proteins. Cholesterol 8-19 CD47 molecule Homo sapiens 92-119 10444074-0 1999 Role of cholesterol in formation and function of a signaling complex involving alphavbeta3, integrin-associated protein (CD47), and heterotrimeric G proteins. Cholesterol 8-19 CD47 molecule Homo sapiens 121-125 10444074-3 1999 The multiply membrane spanning domain of IAP is required for complex formation because it binds cholesterol. Cholesterol 96-107 CD47 molecule Homo sapiens 41-44 10444074-5 1999 Binding of mAb 10G2 to the IAP Ig domain, previously shown to be required for association with alphavbeta3, is affected by both the multiply membrane spanning domain and cholesterol. Cholesterol 170-181 CD47 molecule Homo sapiens 27-30 10444074-6 1999 These data demonstrate that cholesterol is an essential component of the alphavbeta3/IAP/G protein signaling complex, presumably acting through an effect on IAP conformation. Cholesterol 28-39 CD47 molecule Homo sapiens 85-88 10444074-6 1999 These data demonstrate that cholesterol is an essential component of the alphavbeta3/IAP/G protein signaling complex, presumably acting through an effect on IAP conformation. Cholesterol 28-39 CD47 molecule Homo sapiens 157-160 9548474-6 1997 In contrast, cross-linking of CD47 in the presence of CD28 mAb or phorbol ester induces vigorous T cell proliferation that is sensitive to cyclosporin A. Phorbol Esters 66-79 CD47 molecule Homo sapiens 30-34 9548474-6 1997 In contrast, cross-linking of CD47 in the presence of CD28 mAb or phorbol ester induces vigorous T cell proliferation that is sensitive to cyclosporin A. Cyclosporine 139-152 CD47 molecule Homo sapiens 30-34 9548474-7 1997 Cross-linking, but not immobilization, of the CD47 mAb 1/1A4 is an essential requirement for the CD28- or phorbol ester-dependent induction of T cell mitogenesis. Phorbol Esters 106-119 CD47 molecule Homo sapiens 46-50 9169439-0 1997 Thrombspondin acts via integrin-associated protein to activate the platelet integrin alphaIIbbeta3. thrombspondin 0-13 CD47 molecule Homo sapiens 23-50 9169439-3 1997 TS1, the CBD, and an IAP agonist peptide (4N1K) from the CBD of TS1 activate the platelet integrin alphaIIbbeta3, resulting in platelet spreading on immobilized fibrinogen, stimulation of platelet aggregation, and enhanced tyrosine phosphorylation of focal adhesion kinase. Tyrosine 223-231 CD47 molecule Homo sapiens 21-24 8992983-5 1997 IAP cross-linking with B6H12 or BRIC126, but not 2D3, transduces costimulatory signals within highly purified CD3-activated T lymphocytes, i.e., enhancement of proliferation, CD25 expression, and IL-2 secretion, while no effect was observed upon CD2 stimulation. b6h12 23-28 CD47 molecule Homo sapiens 0-3 8992983-5 1997 IAP cross-linking with B6H12 or BRIC126, but not 2D3, transduces costimulatory signals within highly purified CD3-activated T lymphocytes, i.e., enhancement of proliferation, CD25 expression, and IL-2 secretion, while no effect was observed upon CD2 stimulation. bric126 32-39 CD47 molecule Homo sapiens 0-3 8992983-7 1997 In an attempt to explore further the activation signal delivered by IAP, we show here that IAP cross-linking with the comitogenic B6H12 mAb induces the phosphorylation on tyrosine of several proteins, one of which is identified as p56(lck) protein tyrosine kinase. Tyrosine 171-179 CD47 molecule Homo sapiens 68-71 8992983-7 1997 In an attempt to explore further the activation signal delivered by IAP, we show here that IAP cross-linking with the comitogenic B6H12 mAb induces the phosphorylation on tyrosine of several proteins, one of which is identified as p56(lck) protein tyrosine kinase. Tyrosine 171-179 CD47 molecule Homo sapiens 91-94 8996237-8 1997 Furthermore, anti-IAP, but not anti-CD28, synergizes with suboptimal anti-CD3 to enhance tyrosine phosphorylation of the CD3 zeta chain and the T cell-specific tyrosine kinase Zap70. Tyrosine 89-97 CD47 molecule Homo sapiens 18-21 8794870-2 1996 Anti-IAP antibodies inhibit multiple phagocyte functions, including Arg-Gly-Asp (RGD)-initiated activation of phagocytosis, chemotaxis, and respiratory burst; PMN adhesion to entactin; and PMN transendothelial and transepithelial migration at a step subsequent to tight intercellular adhesion. arginyl-glycyl-aspartic acid 68-79 CD47 molecule Homo sapiens 5-8 10085089-5 1999 GTP and AlF4 also reduce the binding of CD47 to its agonist peptide (4N1K) derived from thrombospondin, indicating a direct association of CD47 with Gi. Guanosine Triphosphate 0-3 CD47 molecule Homo sapiens 40-44 10085089-5 1999 GTP and AlF4 also reduce the binding of CD47 to its agonist peptide (4N1K) derived from thrombospondin, indicating a direct association of CD47 with Gi. Guanosine Triphosphate 0-3 CD47 molecule Homo sapiens 139-143 10085089-5 1999 GTP and AlF4 also reduce the binding of CD47 to its agonist peptide (4N1K) derived from thrombospondin, indicating a direct association of CD47 with Gi. tetrafluoroaluminate 8-12 CD47 molecule Homo sapiens 40-44 10085089-5 1999 GTP and AlF4 also reduce the binding of CD47 to its agonist peptide (4N1K) derived from thrombospondin, indicating a direct association of CD47 with Gi. tetrafluoroaluminate 8-12 CD47 molecule Homo sapiens 139-143 8995439-7 1997 The integrin-associated protein remained bound to the RFYVVMWK-containing peptide column when washed with a scrambled peptide in the presence of 5 mM EDTA, indicating a divalent cation-independent association. Edetic Acid 150-154 CD47 molecule Homo sapiens 4-31 7662966-5 1995 Neither platelet aggregation nor intracellular Ca2+ elevation after stimulation was influenced by the anti-IAP antibody, B6H12, which was reported to be inhibitory for other beta 3 integrins. b6h12 121-126 CD47 molecule Homo sapiens 107-110 8376355-6 1993 These results demonstrate that IAP is specifically required for the integrin-regulated calcium influx and suggest that IAP itself might be an integrin-associated calcium channel. Calcium 87-94 CD47 molecule Homo sapiens 31-34 2277087-14 1990 We hypothesize that IAP may play a role in signal transduction for enhanced phagocytosis by Arg-Gly-Asp ligands. Arginine 92-95 CD47 molecule Homo sapiens 20-23 8104228-7 1993 The LRI-IAP-initiated respiratory burst is independent of CD18, as judged by: (a) blockade of inhibition by anti-CD18 mAb with the protein kinase A inhibitor HA1004; (b) enhanced sensitivity of CD18-dependent respiratory burst compared with LRI/IAP-dependent respiratory burst to the tyrosine kinase inhibitors genestein and herbimicin; and (c) generation of a respiratory burst in response to KGAGDV, anti-LRI, and anti-IAP coated surfaces in PMN from a patient with LAD. herbimicin 325-335 CD47 molecule Homo sapiens 8-11 8104228-8 1993 Despite its apparent CD18 independence, LRI/IAP-initiated respiratory burst requires a solid phase ligand and is sensitive to cytochalasin B. Cytochalasin B 126-140 CD47 molecule Homo sapiens 44-47 1401911-1 1992 Integrin-associated protein (IAP) is a 50-kDa intrinsic membrane protein that is involved in signal transduction during neutrophil activation by a variety of Arg-Gly-Asp-containing ligands. Arginine 158-161 CD47 molecule Homo sapiens 0-27 1401911-1 1992 Integrin-associated protein (IAP) is a 50-kDa intrinsic membrane protein that is involved in signal transduction during neutrophil activation by a variety of Arg-Gly-Asp-containing ligands. Arginine 158-161 CD47 molecule Homo sapiens 29-32 1401911-1 1992 Integrin-associated protein (IAP) is a 50-kDa intrinsic membrane protein that is involved in signal transduction during neutrophil activation by a variety of Arg-Gly-Asp-containing ligands. Glycine 162-165 CD47 molecule Homo sapiens 0-27 1401911-1 1992 Integrin-associated protein (IAP) is a 50-kDa intrinsic membrane protein that is involved in signal transduction during neutrophil activation by a variety of Arg-Gly-Asp-containing ligands. Glycine 162-165 CD47 molecule Homo sapiens 29-32 1401911-1 1992 Integrin-associated protein (IAP) is a 50-kDa intrinsic membrane protein that is involved in signal transduction during neutrophil activation by a variety of Arg-Gly-Asp-containing ligands. Aspartic Acid 166-169 CD47 molecule Homo sapiens 0-27 1401911-1 1992 Integrin-associated protein (IAP) is a 50-kDa intrinsic membrane protein that is involved in signal transduction during neutrophil activation by a variety of Arg-Gly-Asp-containing ligands. Aspartic Acid 166-169 CD47 molecule Homo sapiens 29-32 2277087-14 1990 We hypothesize that IAP may play a role in signal transduction for enhanced phagocytosis by Arg-Gly-Asp ligands. Glycine 96-99 CD47 molecule Homo sapiens 20-23 33812633-0 2021 CD47-mediated DTIC-loaded chitosan oligosaccharide-grafted nGO for synergistic chemo-photothermal therapy against malignant melanoma. D-Glucosaminide 26-50 CD47 molecule Homo sapiens 0-4 33812633-4 2021 Herein, chitosan oligosaccharide (COS)-grafted nGO was further modified with CD47 antibody, and loaded DTIC was prepared using a versatile nanoplatform (nGO-COS-CD47/DTIC) for the treatment of melanoma as a synergistic targeted chemo-photothermal therapy. D-Glucosaminide 8-32 CD47 molecule Homo sapiens 77-81 33812633-4 2021 Herein, chitosan oligosaccharide (COS)-grafted nGO was further modified with CD47 antibody, and loaded DTIC was prepared using a versatile nanoplatform (nGO-COS-CD47/DTIC) for the treatment of melanoma as a synergistic targeted chemo-photothermal therapy. D-Glucosaminide 8-32 CD47 molecule Homo sapiens 161-165 33812633-4 2021 Herein, chitosan oligosaccharide (COS)-grafted nGO was further modified with CD47 antibody, and loaded DTIC was prepared using a versatile nanoplatform (nGO-COS-CD47/DTIC) for the treatment of melanoma as a synergistic targeted chemo-photothermal therapy. carbonyl sulfide 34-37 CD47 molecule Homo sapiens 77-81 33812633-4 2021 Herein, chitosan oligosaccharide (COS)-grafted nGO was further modified with CD47 antibody, and loaded DTIC was prepared using a versatile nanoplatform (nGO-COS-CD47/DTIC) for the treatment of melanoma as a synergistic targeted chemo-photothermal therapy. carbonyl sulfide 34-37 CD47 molecule Homo sapiens 161-165 33812633-6 2021 Notably, nGO-COS-CD47/DTIC plus NIR irradiation significantly promoted early cell apoptosis through the mitochondrial apoptosis pathway and exhibited a significant joint function of antitumor efficacy. NGO 9-12 CD47 molecule Homo sapiens 17-21 33812633-6 2021 Notably, nGO-COS-CD47/DTIC plus NIR irradiation significantly promoted early cell apoptosis through the mitochondrial apoptosis pathway and exhibited a significant joint function of antitumor efficacy. Dacarbazine 22-26 CD47 molecule Homo sapiens 17-21 33799989-6 2021 Thirty-five percent of the lesions (95/269) displayed CD47 expression on the cytomembrane of CRC cells. cytomembrane 77-89 CD47 molecule Homo sapiens 54-58 34915428-0 2022 Platinum(IV) complexes as inhibitors of CD47-SIRPalpha axis for chemoimmunotherapy of cancer. Platinum 0-8 CD47 molecule Homo sapiens 40-44 34165607-4 2022 Herein, we developed a CD47 blocking antibody, named IBI188, that could specifically block the CD47-SIRP-alpha axis, which transduces the "don"t eat me" signal to macrophages. ibi188 53-59 CD47 molecule Homo sapiens 23-27 34165607-4 2022 Herein, we developed a CD47 blocking antibody, named IBI188, that could specifically block the CD47-SIRP-alpha axis, which transduces the "don"t eat me" signal to macrophages. ibi188 53-59 CD47 molecule Homo sapiens 95-99 34165607-9 2022 CD47 expression was evaluated following azacytidine (AZA) treatment, a standard-of-care for patients with multiple myeloma; enhanced anti-tumor efficacy was observed in the combination group in AML xenograft models. Azacitidine 40-51 CD47 molecule Homo sapiens 0-4 34165607-9 2022 CD47 expression was evaluated following azacytidine (AZA) treatment, a standard-of-care for patients with multiple myeloma; enhanced anti-tumor efficacy was observed in the combination group in AML xenograft models. Azacitidine 53-56 CD47 molecule Homo sapiens 0-4 34165607-11 2022 These data indicate that IBI188 is a therapeutic anti-CD47 antibody with anti-tumor potency, which can be enhanced when used in combination with standard-of-care drugs for cancer treatment. ibi188 25-31 CD47 molecule Homo sapiens 54-58 34968486-0 2022 Mithramycin suppresses tumor growth by regulating CD47 and PD-L1 expression. Plicamycin 0-11 CD47 molecule Homo sapiens 50-54 34645647-9 2022 Conclusion: Our data demonstrate that an oHSV encoding a full-length human IgG1 anti-CD47 mAb, when used as a single agent or combined with another agent, is a promising approach for improving ovarian cancer treatment via enhancing innate immunity, as well as performing its known oncolytic function and modulation of immune cells. ohsv 41-45 CD47 molecule Homo sapiens 85-89 34921573-4 2022 The nanoprobes are obtained with an amphiphilic co-polymer as the matrix encapsulating TPE-T-RCN molecules, which are further surface functionalized with anti-CD47 antibody for specifically binding to CD47 overexpressed in AS plaques. co-polymer 48-58 CD47 molecule Homo sapiens 201-205 34793719-3 2021 We aimed to evaluate the safety, pharmacokinetics, pharmacodynamics, and anticancer activity of evorpacept (also known as ALX148), a high-affinity CD47-blocking protein with an inactive IgG Fc region in patients with solid tumours. evorpacept 96-106 CD47 molecule Homo sapiens 147-151 34793719-3 2021 We aimed to evaluate the safety, pharmacokinetics, pharmacodynamics, and anticancer activity of evorpacept (also known as ALX148), a high-affinity CD47-blocking protein with an inactive IgG Fc region in patients with solid tumours. alx148 122-128 CD47 molecule Homo sapiens 147-151 34751571-5 2021 A CD47-derived self-peptide ligand (don"t-eat-me signal) and galactose ligand (eat-me signal) were introduced on liposomes. eat-me 79-85 CD47 molecule Homo sapiens 2-6 34841476-6 2021 Interaction with CD47 was inhibited following alkylation of exportin-1 at Cys528 by its covalent inhibitor leptomycin B. leptomycin B 107-117 CD47 molecule Homo sapiens 17-21 34464977-1 2021 Interactions between the IAP antagonist LCL161 and the histone deacetylase inhibitor (HDACI) panobinostat (LBH589) were examined in human multiple myeloma (MM) cells. LCL161 40-46 CD47 molecule Homo sapiens 25-28 34776955-6 2021 Additionally, this study indicated that chaetocin could down-regulate the expression of CD47 at both mRNA and protein levels, and enhance macrophages phagocytosis of CRC cells. chaetocin 40-49 CD47 molecule Homo sapiens 88-92 34559187-3 2021 Based on our findings that breast cancer patients with highly expressed CD47 have poor survival, we evaluated the therapeutic efficacy and underlying mechanisms of combination therapy with the STING ligand cGAMP and an antagonistic anti-CD47 mAb using E0771 mouse breast cancer cells. cyclic guanosine monophosphate-adenosine monophosphate 206-211 CD47 molecule Homo sapiens 72-76 34464977-3 2021 Similar interactions were observed with other HDACIs (MS-275) or IAP antagonists (birinapant). birinapant 82-92 CD47 molecule Homo sapiens 65-68 34471125-3 2021 We present the crystal structure of full length CD47 bound to the function-blocking antibody B6H12. b6h12 93-98 CD47 molecule Homo sapiens 48-52 34573091-7 2021 Moreover, diHEP-DPA blocked immunosuppression by reducing the expression of SIRPalpha in TAMs and CD47 in colorectal cancer cells. dihep-dpa 10-19 CD47 molecule Homo sapiens 98-102 34252800-5 2021 Therefore, we design an early phago-/endosome-escaping micelle that can release platinum-based drugs into the cytoplasm of macrophages and cancer cells, thereby enhancing the ROS levels of the entire tumor tissue; inducing apoptosis of cancer cells, down-regulation of CD47 expression of cancer cells, polarization of M1 macrophages, and phagocytosis of cancer cells by M1 macrophages; and achieving the dual effect of chemotherapy and macrophage-mediated immunotherapy. Platinum 80-88 CD47 molecule Homo sapiens 269-273 34471125-5 2021 Using hydrogen-deuterium exchange and molecular dynamics simulations we show that CD47"s ECLR architecture, comprised of two extracellular loops and the SWF loop, creates a molecular environment stabilizing the ECD for presentation on the cell surface. Hydrogen 6-14 CD47 molecule Homo sapiens 82-86 34471125-5 2021 Using hydrogen-deuterium exchange and molecular dynamics simulations we show that CD47"s ECLR architecture, comprised of two extracellular loops and the SWF loop, creates a molecular environment stabilizing the ECD for presentation on the cell surface. Deuterium 15-24 CD47 molecule Homo sapiens 82-86 34171557-3 2021 Herein, we identified that interferon-gamma (IFN-gamma), one of the most important cytokines in the immune and inflammatory response, up-regulated CD47 expression in cancer cells and this effect could be inhibited by the JAK1/2 inhibitor ruxolitinib, as well as siRNA-mediated silencing of JAK1, STAT1, and IRF1. ruxolitinib 238-249 CD47 molecule Homo sapiens 147-151 34093583-5 2021 Systemic suppression of SIRPalpha+ DCs in animals deficient in CD47 resulted in the inability of autoreactive CD4+ T cells to develop, which is crucial to induction of EAU. Water 168-171 CD47 molecule Homo sapiens 63-67 34425695-3 2021 Using an unbiased quantitative plasma membrane profiling approach, we previously identified CD47 as a putative host target downregulated by Vpu. VPU 140-143 CD47 molecule Homo sapiens 92-96 34425695-5 2021 In this study, we investigate whether CD47 modulation by HIV-1 Vpu might promote the susceptibility of macrophages to viral infection via phagocytosis of infected CD4+ T cells. VPU 63-66 CD47 molecule Homo sapiens 38-42 34425695-6 2021 Indeed, we find that Vpu downregulates CD47 expression on infected CD4+ T cells, leading to enhanced capture and phagocytosis by macrophages. VPU 21-24 CD47 molecule Homo sapiens 39-43 34425695-8 2021 Importantly, we show that HIV-1-infected cells expressing a Vpu-resistant CD47 mutant are less prone to infecting macrophages through phagocytosis. VPU 60-63 CD47 molecule Homo sapiens 74-78 34425695-9 2021 Mechanistically, Vpu forms a physical complex with CD47 through its transmembrane domain and targets the latter for lysosomal degradation. VPU 17-20 CD47 molecule Homo sapiens 51-55 34111474-8 2021 CDDP enhanced the expressions of CD47 in lung cancer cells. cddp 0-4 CD47 molecule Homo sapiens 33-37 34111474-9 2021 Interestingly, the blockage of CD47 enhanced the macrophages" phagocytic activity on the CDDP-treated tumor cells. cddp 89-93 CD47 molecule Homo sapiens 31-35 34477614-4 2021 In this work, we prepared H2O2 self-supplying degradable epitope molecularly imprinted polymers (MIP) for effective CDT, employing fluorescent calcium peroxide (FCaO2) as an imaging probe and a source of H2O2, the exposed peptide in the CD47 extracellular region as the template, copper acrylate as one of the functional monomers and N,N"-bisacrylylcystamine (BAC) as a cross-linker. Hydrogen Peroxide 26-30 CD47 molecule Homo sapiens 237-241 34477614-4 2021 In this work, we prepared H2O2 self-supplying degradable epitope molecularly imprinted polymers (MIP) for effective CDT, employing fluorescent calcium peroxide (FCaO2) as an imaging probe and a source of H2O2, the exposed peptide in the CD47 extracellular region as the template, copper acrylate as one of the functional monomers and N,N"-bisacrylylcystamine (BAC) as a cross-linker. cdt 116-119 CD47 molecule Homo sapiens 237-241 34282107-3 2021 The relationship between CD47 expression and TAM-related microenvironment in endometrial carcinoma (EC) is poorly understood. tam 45-48 CD47 molecule Homo sapiens 25-29 34282107-8 2021 High epithelial and stromal TAMs counts were also associated with high tumoral CD47 expression. tams 28-32 CD47 molecule Homo sapiens 79-83 34205047-2 2021 Moreover, TSP1/CD47 interaction has been found to be associated with platelet hyperaggregability and impaired nitric oxide response, exacerbating progression in IRI and PAH. Nitric Oxide 110-122 CD47 molecule Homo sapiens 15-19 34093583-7 2021 These results identify CD47 as a significant regulator in the development of SIRPalpha+ DCs that is vital to disease induction in EAU. Water 130-133 CD47 molecule Homo sapiens 23-27 35500533-6 2022 Additionally, erythrocytes isolated from subjects with low Se status exhibited cellular damage along with lower protein levels of CD47, which could be aggravated by hydrogen peroxide treatment. Hydrogen Peroxide 165-182 CD47 molecule Homo sapiens 130-134 34068552-0 2021 Repositioning Azelnidipine as a Dual Inhibitor Targeting CD47/SIRPalpha and TIGIT/PVR Pathways for Cancer Immuno-Therapy. azelnidipine 14-26 CD47 molecule Homo sapiens 57-61 34068552-7 2021 Azelnidipine was found to dual block CD47/SIRPalpha and TIGIT/PVR pathways by co-targeting SIRPalpha and PVR. azelnidipine 0-12 CD47 molecule Homo sapiens 37-41 34093795-0 2021 Vitamin E succinate exerts anti-tumour effects on human cervical cancer cells via the CD47-SIRPalpha pathway both in vivo and in vitro. alpha-Tocopherol 0-19 CD47 molecule Homo sapiens 86-90 35134139-6 2022 A combination with paclitaxel dramatically enhanced the anti-cancer efficacy of CD47-targeted therapy toward late-stage NHL. Paclitaxel 19-29 CD47 molecule Homo sapiens 80-84 35134139-9 2022 In addition, we identified a role of paclitaxel in modifying the TME by preventing the accumulation of a TAM subpopulation that is only present in late-stage lymphoma resistant to CD47-targeted therapy. Paclitaxel 37-47 CD47 molecule Homo sapiens 180-184 35134139-9 2022 In addition, we identified a role of paclitaxel in modifying the TME by preventing the accumulation of a TAM subpopulation that is only present in late-stage lymphoma resistant to CD47-targeted therapy. tam 105-108 CD47 molecule Homo sapiens 180-184 34612127-10 2021 In addition, treatment with 120CEM43 increased intracellular HSP70 and the percentage of HCT116/HT29 cells in the G2/M cell cycle phase, ATP release and Calreticulin/HSP70/HSP90 exposure in the plasma membrane, while downregulating CD47 compared to sham-exposed cells. 120cem43 28-36 CD47 molecule Homo sapiens 232-236 35134139-4 2022 Here, we showed that late-stage Non-Hodgkin"s Lymphoma (NHL) was resistant to therapy targeting phagocytosis checkpoint CD47, due to the compromised capacity of TAMs to phagocytose lymphoma cells. tams 161-165 CD47 molecule Homo sapiens 120-124 35447106-10 2022 Ethyl acetate was found to be the optimum cosolvent, improving the loading efficiency of anti-CD47 in poly(lactic-co-glycolic acid), PLGA, nanoparticles to 90% or higher, and the antibody was found to retain its activity after being released from nanoparticles. ethyl acetate 0-13 CD47 molecule Homo sapiens 94-98 35447106-10 2022 Ethyl acetate was found to be the optimum cosolvent, improving the loading efficiency of anti-CD47 in poly(lactic-co-glycolic acid), PLGA, nanoparticles to 90% or higher, and the antibody was found to retain its activity after being released from nanoparticles. Polylactic Acid-Polyglycolic Acid Copolymer 102-131 CD47 molecule Homo sapiens 94-98 35410993-5 2022 In addition, 4-methylumbelliferone (4MU), a cholecystitis drug, can disrupt the CD47/SIRPalpha axis by disturbing glioblastoma HA synthesis. Hymecromone 36-39 CD47 molecule Homo sapiens 80-84 34981142-0 2022 Phase 1 study of anti-CD47 monoclonal antibody CC-90002 in patients with relapsed/refractory acute myeloid leukemia and high-risk myelodysplastic syndromes. cc-90002 47-55 CD47 molecule Homo sapiens 22-26 35314680-0 2022 Fatty acid oxidation fuels glioblastoma radioresistance with CD47-mediated immune evasion. Fatty Acids 0-10 CD47 molecule Homo sapiens 61-65 35410993-5 2022 In addition, 4-methylumbelliferone (4MU), a cholecystitis drug, can disrupt the CD47/SIRPalpha axis by disturbing glioblastoma HA synthesis. Hymecromone 13-34 CD47 molecule Homo sapiens 80-84 35406573-7 2022 In contrast, high SIRPalpha expression by CD68+ TAMs (SIRPalpha/CD68-ratio) was linked with CD47 expression by cancer cells, low TIL-score, and poor prognosis (p = 0.02). Tamoxifen 48-52 CD47 molecule Homo sapiens 92-96 35287686-10 2022 DSP107 treatment activated 4-1BB-mediated costimulatory signaling by HT1080.4-1BB reporter cells, which was strictly dependent on the SIRPalpha-mediated binding of DSP107 to CD47. dsp107 0-6 CD47 molecule Homo sapiens 174-178 34981142-1 2022 CC-90002 is an anti-CD47 antibody that inhibits CD47-SIRPalpha interaction and enables macrophage-mediated killing of tumor cells in hematological cancer cell lines. cc-90002 0-8 CD47 molecule Homo sapiens 20-24 34981142-1 2022 CC-90002 is an anti-CD47 antibody that inhibits CD47-SIRPalpha interaction and enables macrophage-mediated killing of tumor cells in hematological cancer cell lines. cc-90002 0-8 CD47 molecule Homo sapiens 48-52 35295998-7 2022 Freshly isolated upper urinary tract specimens were incubated with anti-CD47-Alexa Fluor 790 and then imaged under white light and near-infrared (NIR) light. alexa fluor 790 77-92 CD47 molecule Homo sapiens 72-76 35040313-3 2022 The obtained complex (named OXA-NO) could significantly increase the level of "eat me" signal CRT expression and decrease the level of "don"t eat me" signal CD47 expression on cancer cell membranes to promote their phagocytosis by macrophages. oxa-no 28-34 CD47 molecule Homo sapiens 157-161