PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
31390771-1	2019	A mutant defective in the biosynthesis of thermospermine, acaulis5 (acl5), shows a dwarf phenotype with excess xylem vessels in Arabidopsis thaliana.	thermospermine	42-56	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	68-72
31257654-2	2019	Studies on acaulis5 (acl5), a mutant defective in the biosynthesis of thermospermine, have revealed that thermospermine plays a repressive role in xylem development through enhancement of mRNA translation of the SAC51 family.	thermospermine	70-84	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	21-25
31257654-2	2019	Studies on acaulis5 (acl5), a mutant defective in the biosynthesis of thermospermine, have revealed that thermospermine plays a repressive role in xylem development through enhancement of mRNA translation of the SAC51 family.	thermospermine	105-119	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	21-25
33304375-3	2020	Overexpression of ACAULIS5 from the constitutive 35S promoter in hybrid aspen (Populus tremula x Populus tremuloides) trees suppressed the expression level of ACAULIS5, which resulted in low levels of the physiologically active cytokinin bases as well as their direct riboside precursors in the transgenic lines.	Sulfur-35	49-52	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	18-26
33304375-3	2020	Overexpression of ACAULIS5 from the constitutive 35S promoter in hybrid aspen (Populus tremula x Populus tremuloides) trees suppressed the expression level of ACAULIS5, which resulted in low levels of the physiologically active cytokinin bases as well as their direct riboside precursors in the transgenic lines.	Sulfur-35	49-52	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	159-167
33304375-3	2020	Overexpression of ACAULIS5 from the constitutive 35S promoter in hybrid aspen (Populus tremula x Populus tremuloides) trees suppressed the expression level of ACAULIS5, which resulted in low levels of the physiologically active cytokinin bases as well as their direct riboside precursors in the transgenic lines.	riboside	268-276	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	18-26
33304375-3	2020	Overexpression of ACAULIS5 from the constitutive 35S promoter in hybrid aspen (Populus tremula x Populus tremuloides) trees suppressed the expression level of ACAULIS5, which resulted in low levels of the physiologically active cytokinin bases as well as their direct riboside precursors in the transgenic lines.	riboside	268-276	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	159-167
31257654-4	2019	Here we compared acl5 with a mutant of spermine synthase, spms, in terms of abiotic stress tolerance and found that acl5 was much more sensitive to sodium than the wild-type and spms.	Sodium	148-154	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	116-120
31257654-6	2019	Together with the result that the salt tolerance of both wild-type and acl5 seedlings was improved by long-term treatment with thermospermine, we suggest a correlation of the salt tolerance with reduced xylem development rather than with the thermospermine level.	thermospermine	127-141	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	71-75
29080154-2	2018	An Arabidopsis mutant, acaulis5 (acl5), that is defective in the biosynthesis of thermospermine displays excessive proliferation of xylem vessels with dwarfed growth.	thermospermine	81-95	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	23-31
28045577-1	2017	The excessive xylem phenotype of acaulis5 (acl5), an Arabidopsis mutant defective in the synthesis of thermospermine, indicates that thermospermine is required for negative regulation of xylem differentiation.	thermospermine	102-116	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	43-47
28045577-1	2017	The excessive xylem phenotype of acaulis5 (acl5), an Arabidopsis mutant defective in the synthesis of thermospermine, indicates that thermospermine is required for negative regulation of xylem differentiation.	thermospermine	133-147	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	43-47
26056006-0	2015	Characterization of spermidine synthase and spermine synthase--The polyamine-synthetic enzymes that induce early flowering in Gentiana triflora.	Polyamines	67-76	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	44-61
27388339-1	2016	The acaulis5 (acl5) mutant of Arabidopsis thaliana is defective in the biosynthesis of thermospermine and shows a dwarf phenotype associated with excess xylem differentiation.	thermospermine	87-101	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	14-18
26209974-0	2015	Cotton ACAULIS5 is involved in stem elongation and the plant defense response to Verticillium dahliae through thermospermine alteration.	thermospermine	110-124	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	7-15
26056006-3	2015	Here, we identified homologs of two Arabidopsis polyamine-synthetic enzymes, spermidine synthase (SPDS) and spermine synthase (SPMS) denoted as GtSPDS and GtSPMS, from the gentian plant, Gentiana triflora.	Polyamines	48-57	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	108-125
25625317-1	2015	Thermospermine acts in negative regulation of xylem differentiation and its deficient mutant of Arabidopsis thaliana, acaulis5 (acl5), shows excessive xylem formation and severe dwarfism.	thermospermine	0-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	118-126
25625317-1	2015	Thermospermine acts in negative regulation of xylem differentiation and its deficient mutant of Arabidopsis thaliana, acaulis5 (acl5), shows excessive xylem formation and severe dwarfism.	thermospermine	0-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	128-132
24777988-2	2014	It has been suggested that thermospermine produced by ACAULIS5 (ACL5) and bushy and dwarf2 (BUD2) is one of the factors downstream to auxin contributing to the regulation of this process in Arabidopsis.	thermospermine	27-41	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	54-62
24777988-2	2014	It has been suggested that thermospermine produced by ACAULIS5 (ACL5) and bushy and dwarf2 (BUD2) is one of the factors downstream to auxin contributing to the regulation of this process in Arabidopsis.	thermospermine	27-41	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	64-68
24777988-5	2014	This mechanism involves the positive regulation of thermospermine biosynthesis by the HD-ZIP III protein Arabidopsis thaliana homeobox8 tightly controlling the expression of ACL5 and BUD2.	thermospermine	51-65	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	174-178
24672532-1	2014	Thermospermine, a structural isomer of spermine, is widely distributed in the plant kingdom and has been shown to play a role in repressing xylem differentiation by studies of its deficient mutant, acaulis5 (acl5), in Arabidopsis.	thermospermine	0-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	198-206
24672532-1	2014	Thermospermine, a structural isomer of spermine, is widely distributed in the plant kingdom and has been shown to play a role in repressing xylem differentiation by studies of its deficient mutant, acaulis5 (acl5), in Arabidopsis.	thermospermine	0-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	208-212
24672532-1	2014	Thermospermine, a structural isomer of spermine, is widely distributed in the plant kingdom and has been shown to play a role in repressing xylem differentiation by studies of its deficient mutant, acaulis5 (acl5), in Arabidopsis.	Spermine	6-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	198-206
24672532-1	2014	Thermospermine, a structural isomer of spermine, is widely distributed in the plant kingdom and has been shown to play a role in repressing xylem differentiation by studies of its deficient mutant, acaulis5 (acl5), in Arabidopsis.	Spermine	6-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	208-212
24672532-5	2014	We examined the effect of synthetic polyamines on the expression of these auxin-related genes and on the vascular phenotype of acl5, and found that tetramines containing the NC3NC3N chain could mimic the effect of thermospermine but longer polyamines containing the same chain had little or no such effect.	tetramethylenedisulfotetramine	148-158	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	127-131
24672532-5	2014	We examined the effect of synthetic polyamines on the expression of these auxin-related genes and on the vascular phenotype of acl5, and found that tetramines containing the NC3NC3N chain could mimic the effect of thermospermine but longer polyamines containing the same chain had little or no such effect.	thermospermine	214-228	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	127-131
22366038-1	2012	Thermospermine is a structural isomer of spermine, which is one of the polyamines studied extensively in the past, and is produced from spermidine by the action of thermospermine synthase encoded by a gene named ACAULIS5 (ACL5) in plants.	thermospermine	0-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	212-220
22751360-1	2012	Thermospermine, a structural isomer of spermine, is synthesized by a thermospermine synthase designated ACAULIS5 (ACL5).	thermospermine	0-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	104-112
22751360-1	2012	Thermospermine, a structural isomer of spermine, is synthesized by a thermospermine synthase designated ACAULIS5 (ACL5).	thermospermine	0-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	114-118
22751360-1	2012	Thermospermine, a structural isomer of spermine, is synthesized by a thermospermine synthase designated ACAULIS5 (ACL5).	Spermine	6-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	104-112
22751360-1	2012	Thermospermine, a structural isomer of spermine, is synthesized by a thermospermine synthase designated ACAULIS5 (ACL5).	Spermine	6-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	114-118
22751360-2	2012	Thermospermine-deficient acl5 mutant of Arabidopsis thaliana shows severe dwarfism and excessive xylem differentiation.	thermospermine	0-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	25-29
24734036-1	2014	It has been previously described that elevation of endogenous spermine levels in Arabidopsis could be achieved by transgenic overexpression of S-Adenosylmethionine decarboxylase (SAMDC) or Spermine synthase (SPMS).	Spermine	62-70	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	189-206
22345435-1	2012	Thermospermine, a structural isomer of spermine, is produced through the action of ACAULIS5 (ACL5) and suppresses xylem differentiation in Arabidopsis thaliana.	thermospermine	0-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	83-91
22345435-1	2012	Thermospermine, a structural isomer of spermine, is produced through the action of ACAULIS5 (ACL5) and suppresses xylem differentiation in Arabidopsis thaliana.	thermospermine	0-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	93-97
22345435-1	2012	Thermospermine, a structural isomer of spermine, is produced through the action of ACAULIS5 (ACL5) and suppresses xylem differentiation in Arabidopsis thaliana.	Spermine	6-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	83-91
22345435-1	2012	Thermospermine, a structural isomer of spermine, is produced through the action of ACAULIS5 (ACL5) and suppresses xylem differentiation in Arabidopsis thaliana.	Spermine	6-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	93-97
22345435-2	2012	To elucidate the molecular basis of the function of thermospermine, we screened chemical libraries for compounds that can modulate xylem differentiation in the acl5 mutant, which is deficient in thermospermine and shows a severe dwarf phenotype associated with excessive proliferation of xylem vessels.	thermospermine	52-66	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	160-164
22345435-2	2012	To elucidate the molecular basis of the function of thermospermine, we screened chemical libraries for compounds that can modulate xylem differentiation in the acl5 mutant, which is deficient in thermospermine and shows a severe dwarf phenotype associated with excessive proliferation of xylem vessels.	thermospermine	195-209	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	160-164
22366038-1	2012	Thermospermine is a structural isomer of spermine, which is one of the polyamines studied extensively in the past, and is produced from spermidine by the action of thermospermine synthase encoded by a gene named ACAULIS5 (ACL5) in plants.	thermospermine	0-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	222-226
22345435-3	2012	We found that the isooctyl ester of a synthetic auxin, 2,4-D, remarkably enhanced xylem vessel differentiation in acl5 seedlings.	isooctyl ester	18-32	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	114-118
22366038-1	2012	Thermospermine is a structural isomer of spermine, which is one of the polyamines studied extensively in the past, and is produced from spermidine by the action of thermospermine synthase encoded by a gene named ACAULIS5 (ACL5) in plants.	Spermine	6-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	212-220
22345435-5	2012	These effects of auxin analogs were observed only in the acl5 mutant but not in the wild type, and were suppressed by the anti-auxin, p-chlorophenoxyisobutyric acid (PCIB) and alpha-(phenyl ethyl-2-one)-IAA (PEO-IAA), and also by thermospermine.	Clofibric Acid	134-164	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	57-61
22366038-1	2012	Thermospermine is a structural isomer of spermine, which is one of the polyamines studied extensively in the past, and is produced from spermidine by the action of thermospermine synthase encoded by a gene named ACAULIS5 (ACL5) in plants.	Spermine	6-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	222-226
22345435-5	2012	These effects of auxin analogs were observed only in the acl5 mutant but not in the wild type, and were suppressed by the anti-auxin, p-chlorophenoxyisobutyric acid (PCIB) and alpha-(phenyl ethyl-2-one)-IAA (PEO-IAA), and also by thermospermine.	Clofibric Acid	166-170	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	57-61
22345435-5	2012	These effects of auxin analogs were observed only in the acl5 mutant but not in the wild type, and were suppressed by the anti-auxin, p-chlorophenoxyisobutyric acid (PCIB) and alpha-(phenyl ethyl-2-one)-IAA (PEO-IAA), and also by thermospermine.	alpha-(phenyl ethyl-2-one)-iaa	176-206	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	57-61
22366038-1	2012	Thermospermine is a structural isomer of spermine, which is one of the polyamines studied extensively in the past, and is produced from spermidine by the action of thermospermine synthase encoded by a gene named ACAULIS5 (ACL5) in plants.	Polyamines	71-81	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	212-220
22366038-1	2012	Thermospermine is a structural isomer of spermine, which is one of the polyamines studied extensively in the past, and is produced from spermidine by the action of thermospermine synthase encoded by a gene named ACAULIS5 (ACL5) in plants.	Spermidine	136-146	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	212-220
22366038-1	2012	Thermospermine is a structural isomer of spermine, which is one of the polyamines studied extensively in the past, and is produced from spermidine by the action of thermospermine synthase encoded by a gene named ACAULIS5 (ACL5) in plants.	Spermidine	136-146	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	222-226
22345435-5	2012	These effects of auxin analogs were observed only in the acl5 mutant but not in the wild type, and were suppressed by the anti-auxin, p-chlorophenoxyisobutyric acid (PCIB) and alpha-(phenyl ethyl-2-one)-IAA (PEO-IAA), and also by thermospermine.	PEO-IAA	208-215	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	57-61
22345435-5	2012	These effects of auxin analogs were observed only in the acl5 mutant but not in the wild type, and were suppressed by the anti-auxin, p-chlorophenoxyisobutyric acid (PCIB) and alpha-(phenyl ethyl-2-one)-IAA (PEO-IAA), and also by thermospermine.	thermospermine	230-244	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	57-61
22366038-4	2012	Loss-of-function mutants of ACL5 display overproliferation of xylem vessels along with severe dwarfism, suggesting that thermospermine plays a role in the repression of xylem differentiation.	thermospermine	120-134	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	28-32
22345435-6	2012	Furthermore, the suppressor of acaulis51-d (sac51-d) mutation, which causes SAC51 overexpression in the absence of thermospermine and suppresses the dwarf phenotype of acl5, also suppressed the effect of auxin analogs in acl5.	thermospermine	115-129	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	168-172
22366038-5	2012	Studies of suppressor mutants of acl5 that recover the wild-type phenotype in the absence of thermospermine suggest that thermospermine acts on the translation of specific mRNAs containing upstream open reading frames (uORFs).	thermospermine	93-107	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	33-37
22345435-6	2012	Furthermore, the suppressor of acaulis51-d (sac51-d) mutation, which causes SAC51 overexpression in the absence of thermospermine and suppresses the dwarf phenotype of acl5, also suppressed the effect of auxin analogs in acl5.	thermospermine	115-129	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	221-225
22366038-5	2012	Studies of suppressor mutants of acl5 that recover the wild-type phenotype in the absence of thermospermine suggest that thermospermine acts on the translation of specific mRNAs containing upstream open reading frames (uORFs).	thermospermine	121-135	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	33-37
21628628-0	2011	Perturbation of spermine synthase gene expression and transcript profiling provide new insights on the role of the tetraamine spermine in Arabidopsis defense against Pseudomonas viridiflava.	tetraamine spermine	115-134	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	16-33
20137962-4	2010	The relevance of the method was confirmed by co-chromatography with respective PAs and by the PA analysis of the single- and double-mutants of acl5 and spms, which could not synthesize thermospermine and/or spermine, respectively.	thermospermine	185-199	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	143-147
20580714-3	2010	Exogenous application of norspermine to acl5, a mutant defective in the synthesis of thermospermine, partially suppressed its dwarf phenotype, and down-regulated the level of the acl5 transcript which is much higher than that of the ACL5 transcript in the wild type.	norspermine	25-36	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	40-44
20580714-3	2010	Exogenous application of norspermine to acl5, a mutant defective in the synthesis of thermospermine, partially suppressed its dwarf phenotype, and down-regulated the level of the acl5 transcript which is much higher than that of the ACL5 transcript in the wild type.	norspermine	25-36	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	179-183
20580714-3	2010	Exogenous application of norspermine to acl5, a mutant defective in the synthesis of thermospermine, partially suppressed its dwarf phenotype, and down-regulated the level of the acl5 transcript which is much higher than that of the ACL5 transcript in the wild type.	norspermine	25-36	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	233-237
20580714-3	2010	Exogenous application of norspermine to acl5, a mutant defective in the synthesis of thermospermine, partially suppressed its dwarf phenotype, and down-regulated the level of the acl5 transcript which is much higher than that of the ACL5 transcript in the wild type.	thermospermine	85-99	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	40-44
20137962-4	2010	The relevance of the method was confirmed by co-chromatography with respective PAs and by the PA analysis of the single- and double-mutants of acl5 and spms, which could not synthesize thermospermine and/or spermine, respectively.	Spermine	191-199	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	143-147
20137964-4	2010	Thermospermine biosynthesis is catalyzed by the aminopropyl transferase encoded by ACAULIS5, which is specifically expressed in xylem vessel elements.	thermospermine	0-14	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	83-91
19704669-3	2007	In the present studies, we assessed whether spermine among the polyamines plays a certain role against high salt and drought stresses using an Arabidopsis (acl5/spms) mutant plant that does not produce spermine, and found that it was hypersensitive to those stresses.	Spermine	44-52	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	156-160
18669523-3	2008	A more recent study, however, showed that the bacterial expressed recombinant ACL5 protein catalyzes the conversion of spermidine to thermospermine, a structural isomer of spermine, rather than to spermine.	Spermidine	119-129	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	78-82
18669523-3	2008	A more recent study, however, showed that the bacterial expressed recombinant ACL5 protein catalyzes the conversion of spermidine to thermospermine, a structural isomer of spermine, rather than to spermine.	thermospermine	133-147	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	78-82
18669523-3	2008	A more recent study, however, showed that the bacterial expressed recombinant ACL5 protein catalyzes the conversion of spermidine to thermospermine, a structural isomer of spermine, rather than to spermine.	Spermine	139-147	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	78-82
18669523-3	2008	A more recent study, however, showed that the bacterial expressed recombinant ACL5 protein catalyzes the conversion of spermidine to thermospermine, a structural isomer of spermine, rather than to spermine.	Spermine	172-180	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	78-82
18669523-6	2008	Daily application of 0.1 mM thermospermine onto the shoot apex partially rescued the dwarf phenotype of acl5-1, while that of spermine had no effects on the morphology of the mutant.	thermospermine	28-42	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	104-108
18669523-6	2008	Daily application of 0.1 mM thermospermine onto the shoot apex partially rescued the dwarf phenotype of acl5-1, while that of spermine had no effects on the morphology of the mutant.	Spermine	34-42	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	104-108
18669523-7	2008	The acl5-1 transcript level in acl5-1 seedlings, which is much higher than the ACL5 transcript level in wild-type seedlings, was reduced by exogenous thermospermine.	thermospermine	150-164	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	4-8
18669523-7	2008	The acl5-1 transcript level in acl5-1 seedlings, which is much higher than the ACL5 transcript level in wild-type seedlings, was reduced by exogenous thermospermine.	thermospermine	150-164	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	31-35
18669523-7	2008	The acl5-1 transcript level in acl5-1 seedlings, which is much higher than the ACL5 transcript level in wild-type seedlings, was reduced by exogenous thermospermine.	thermospermine	150-164	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	79-83
18669523-8	2008	Thus we conclude that thermospermine is indeed produced through the action of ACL5 and required for stem elongation in Arabidopsis.	thermospermine	22-36	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	78-82
18599510-2	2008	Through detailed anatomical characterization of Arabidopsis thaliana hypocotyls, we observed that mutations in the putative spermine biosynthetic gene ACL5 severely affected xylem specification: the xylem vessel elements of the acl5 mutant were small and mainly of the spiral type, and the normally predominant pitted vessels as well as the xylem fibers were completely missing.	Spermine	124-132	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	151-155
18599510-2	2008	Through detailed anatomical characterization of Arabidopsis thaliana hypocotyls, we observed that mutations in the putative spermine biosynthetic gene ACL5 severely affected xylem specification: the xylem vessel elements of the acl5 mutant were small and mainly of the spiral type, and the normally predominant pitted vessels as well as the xylem fibers were completely missing.	Spermine	124-132	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	228-232
18599510-4	2008	Exogenous spermine prolonged xylem element differentiation and stimulated cell expansion and cell wall elaboration in xylogenic cell cultures of Zinnia elegans, suggesting that ACL5 prevents premature death of the developing vessel elements to allow complete expansion and secondary cell wall patterning.	Spermine	10-18	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	177-181
17118338-3	2007	We found that an Arabidopsis mutant plant (acl5/spms), which cannot produce spermine, is hypersensitive to high salt.	Spermine	76-84	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	43-47
17118338-3	2007	We found that an Arabidopsis mutant plant (acl5/spms), which cannot produce spermine, is hypersensitive to high salt.	Salts	112-116	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	43-47
10944107-2	2000	Here we show that the Arabidopsis: ACAULIS5 (ACL5) gene, whose inactivation causes a defect in the elongation of stem internodes by reducing cell expansion, encodes a protein that shares sequence similarity with the polyamine biosynthetic enzymes spermidine synthase and spermine synthase.	Polyamines	216-225	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	35-43
10944107-2	2000	Here we show that the Arabidopsis: ACAULIS5 (ACL5) gene, whose inactivation causes a defect in the elongation of stem internodes by reducing cell expansion, encodes a protein that shares sequence similarity with the polyamine biosynthetic enzymes spermidine synthase and spermine synthase.	Polyamines	216-225	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	45-49