PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33046533-3	2020	Although the majority of the 1,157-nucleotide (nt) Saccharomyces cerevisiae telomerase RNA, TLC1, is rapidly evolving, the central catalytic core is largely conserved, containing the template, template-boundary helix, pseudoknot, and core-enclosing helix (CEH).	1,157-nucleotide	29-45	TLC1	Saccharomyces cerevisiae S288C	92-96
33046533-3	2020	Although the majority of the 1,157-nucleotide (nt) Saccharomyces cerevisiae telomerase RNA, TLC1, is rapidly evolving, the central catalytic core is largely conserved, containing the template, template-boundary helix, pseudoknot, and core-enclosing helix (CEH).	nt	47-49	TLC1	Saccharomyces cerevisiae S288C	92-96
32121425-4	2020	Here, we first show that Sm7 can stabilize poly(A)- TLC1 even when its binding site is repositioned via circular permutation to several different positions within TLC1, further supporting the conclusion that the telomerase holoenzyme is organizationally flexible.	Poly A	43-50	TLC1	Saccharomyces cerevisiae S288C	52-56
28637749-5	2017	In the presence of DSBs, TLC1 RNA remains nucleolar in most G2/M cells but accumulates in the nucleoplasm and colocalizes with DSBs in rad52Delta cells, leading to de novo telomere additions.	dsbs	19-23	TLC1	Saccharomyces cerevisiae S288C	25-29
23610127-5	2013	To address this question, we localized the Ku-binding site of the TLC1 hairpin with single-nucleotide resolution using phosphorothioate footprinting, used chemical modification to identify an unpredicted motif within the hairpin secondary structure, and carried out mutagenesis of the stem-loop to ascertain the critical elements within the RNA that permit Ku binding.	Parathion	119-135	TLC1	Saccharomyces cerevisiae S288C	66-70
16299517-3	2005	Here, we reduce the 1,157-nucleotide (nt) Saccharomyces cerevisiae TLC1 RNA to a size smaller than the 451-nt human RNA while retaining function in vivo.	1,157-nucleotide	20-36	TLC1	Saccharomyces cerevisiae S288C	67-71
18840651-2	2008	TLC1 shares several features with snRNA, among them the presence of a trimethylguanosine (m(3)G) cap structure at the 5" end of the RNA.	trimethylguanosine	70-88	TLC1	Saccharomyces cerevisiae S288C	0-4
19875981-3	2010	Sas2 acetylates histone H4 lysine 16 (H4K16), and telomere shortening in tlc1 mutants was accompanied by a selective and Sas2-dependent increase in subtelomeric H4K16 acetylation.	Lysine	27-33	TLC1	Saccharomyces cerevisiae S288C	73-77
15813705-4	2005	The GST-Est2p-Tlc1 complex was partially purified by ammonium sulphate fractionation and affinity chromatography on glutathione beads, and the partially purified telomerase did not contain the other two subunits of the telomerase holoenzyme, Est1p and Est3p.	Ammonium Sulfate	53-70	TLC1	Saccharomyces cerevisiae S288C	14-18
15813705-4	2005	The GST-Est2p-Tlc1 complex was partially purified by ammonium sulphate fractionation and affinity chromatography on glutathione beads, and the partially purified telomerase did not contain the other two subunits of the telomerase holoenzyme, Est1p and Est3p.	Glutathione	116-127	TLC1	Saccharomyces cerevisiae S288C	14-18
12167699-2	2002	The RNA component of yeast telomerase (Tlc1) is synthesized as a polyadenylated precursor and then processed to a mature poly(A)- form.	Poly A	121-128	TLC1	Saccharomyces cerevisiae S288C	39-43
15531893-4	2004	The effects of Ku on telomerase binding require a 48-nucleotide (nt) stem-loop region of TLC1 telomerase RNA.	48-nucleotide	50-63	TLC1	Saccharomyces cerevisiae S288C	89-93
12167699-9	2002	Second, Mtr10p may be necessary for the nuclear import of some enzyme needed for the nuclear processing and maturation of Tlc1, and in the absence of this maturation, poly(A)+ Tlc1 is aberrantly exported to the cytoplasm (the "processing enzyme" model).	Poly A	167-174	TLC1	Saccharomyces cerevisiae S288C	122-126
12167699-9	2002	Second, Mtr10p may be necessary for the nuclear import of some enzyme needed for the nuclear processing and maturation of Tlc1, and in the absence of this maturation, poly(A)+ Tlc1 is aberrantly exported to the cytoplasm (the "processing enzyme" model).	Poly A	167-174	TLC1	Saccharomyces cerevisiae S288C	176-180
8610124-7	1996	The activity immunoprecipitated from TLC1-1 mutant strains incorporated 32P-labeled dCTP, while activity from TLC1 strains did not.	Phosphorus-32	72-75	TLC1	Saccharomyces cerevisiae S288C	37-43
10733598-5	2000	Previously, we showed that a specific trinucleotide substitution in the Saccharomyces cerevisiae telomerase gene (TLC1) RNA template abolished the enzymatic activity of telomerase, causing the same cell senescence and telomere shortening phenotypes as a complete tlc1 deletion.	trinucleotide	38-51	TLC1	Saccharomyces cerevisiae S288C	114-118
10733598-5	2000	Previously, we showed that a specific trinucleotide substitution in the Saccharomyces cerevisiae telomerase gene (TLC1) RNA template abolished the enzymatic activity of telomerase, causing the same cell senescence and telomere shortening phenotypes as a complete tlc1 deletion.	trinucleotide	38-51	TLC1	Saccharomyces cerevisiae S288C	263-267
9042865-4	1997	We mutated the S. cerevisiae telomerase RNA (TLC1) with a series of 3-base (GUG) substitutions in and next to the 17-nucleotide templating domain.	17-nucleotide	114-127	TLC1	Saccharomyces cerevisiae S288C	45-49
8610124-7	1996	The activity immunoprecipitated from TLC1-1 mutant strains incorporated 32P-labeled dCTP, while activity from TLC1 strains did not.	Phosphorus-32	72-75	TLC1	Saccharomyces cerevisiae S288C	37-41
8610124-7	1996	The activity immunoprecipitated from TLC1-1 mutant strains incorporated 32P-labeled dCTP, while activity from TLC1 strains did not.	2'-deoxycytidine 5'-triphosphate	84-88	TLC1	Saccharomyces cerevisiae S288C	37-43
8610124-7	1996	The activity immunoprecipitated from TLC1-1 mutant strains incorporated 32P-labeled dCTP, while activity from TLC1 strains did not.	2'-deoxycytidine 5'-triphosphate	84-88	TLC1	Saccharomyces cerevisiae S288C	37-41