PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
17875315-2	2007	This lifespan extension was dependent on an NAD(+)-dependent histone deacetylase, Sir2 in Drosophila and SIR-2.1 in C. elegans.	NAD	44-50	Sirtuin 1	Drosophila melanogaster	82-86
12571358-1	2003	Sir2 is an NAD-dependent histone deacetylase required for transcriptional silencing.	NAD	11-14	Sirtuin 1	Drosophila melanogaster	0-4
16626303-1	2006	Resveratrol mimics calorie restriction to extend lifespan of Caenorhabditis elegans, yeast and Drosophila, possibly through activation of Sir2 (silent information regulator 2), a NAD+-dependent histone deacetylase.	Resveratrol	0-11	Sirtuin 1	Drosophila melanogaster	138-142
16626303-1	2006	Resveratrol mimics calorie restriction to extend lifespan of Caenorhabditis elegans, yeast and Drosophila, possibly through activation of Sir2 (silent information regulator 2), a NAD+-dependent histone deacetylase.	Resveratrol	0-11	Sirtuin 1	Drosophila melanogaster	144-174
12571358-3	2003	First, we performed histone deacetylation assays and found that dSir2 deacetylates a broad range of acetylated lysine residues.	Lysine	111-117	Sirtuin 1	Drosophila melanogaster	64-69
12571358-8	2003	With this hyperacetylated histone-DNA complex, we observed potent (50- to 100-fold) NAD-dependent transcriptional repression by purified dSir2.	NAD	84-87	Sirtuin 1	Drosophila melanogaster	137-142
12571358-9	2003	In contrast, repression by dSir2 was not observed in parallel experiments in which histones were hyperpropionylated with propionic anhydride.	propionic anhydride	121-140	Sirtuin 1	Drosophila melanogaster	27-32
12571358-10	2003	We also found that dSir2 mediates the formation of a nuclease-resistant fast-sedimenting histone-DNA complex in an NAD-dependent manner.	NAD	115-118	Sirtuin 1	Drosophila melanogaster	19-24
12535671-2	2003	Recently, it was shown that the Drosophila bHLH repressor proteins, Hairy and Deadpan, bind to and function with the NAD(+)-dependent histone deacetylase, Sir2.	NAD	117-123	Sirtuin 1	Drosophila melanogaster	155-159
34893548-11	2022	This retained mitochondrial activity is likely mediated by Sirt1 and PGC1alpha, and is key to cisplatin resistance.	Cisplatin	94-103	Sirtuin 1	Drosophila melanogaster	59-64
12524341-6	2002	We found that dSir2 expression is developmentally regulated and that dSir2 has an intrinsic NAD(+)-dependent histone deacetylase activity.	NAD	92-98	Sirtuin 1	Drosophila melanogaster	69-74
12086602-1	2002	Yeast SIR2 is a NAD+-dependent histone deacetylase required for heterochromatic silencing at telomeres, rDNA, and mating-type loci.	NAD	16-19	Sirtuin 1	Drosophila melanogaster	6-10
11281647-5	2001	Recombinant dHDAC6 and dSIR2 are both insensitive to TSA and HC toxin and resistant, relative to dHDAC1 and dHDAC3, to inhibition by sodium butyrate.	trichostatin A	53-56	Sirtuin 1	Drosophila melanogaster	23-28
11281647-5	2001	Recombinant dHDAC6 and dSIR2 are both insensitive to TSA and HC toxin and resistant, relative to dHDAC1 and dHDAC3, to inhibition by sodium butyrate.	Butyric Acid	133-148	Sirtuin 1	Drosophila melanogaster	23-28
28252007-0	2017	Alkylresorcinols activate SIRT1 and delay ageing in Drosophila melanogaster.	alkylresorcinols	0-16	Sirtuin 1	Drosophila melanogaster	26-31
31624074-8	2019	The results showed that either a HFD or dSir2 knockdown remarkably increased cardiac TG level and d FAS expression, reduced heart fractional shortening and diastolic diameter, increased arrhythmia index, and decreased heart NAD+ level, dSIR2 protein, dSir2 and PGC-1alpha expression levels.	NAD	224-227	Sirtuin 1	Drosophila melanogaster	40-45
31624074-9	2019	Contrarily, either exercise or dSir2 overexpression remarkably reduced heart TG level, dFAS expression and arrhythmia index, and notably increased heart fractional shortening, diastolic diameter, NAD+ level, dSIR2 level, and heart dSir2 and PGC-1alpha expression.	NAD	196-199	Sirtuin 1	Drosophila melanogaster	31-36
31624074-10	2019	Therefore, we declared that exercise training could improve lipotoxic cardiomyopathy induced by a HFD or cardiac dSir2 knockdown in old Drosophila The NAD+/dSIR2/PGC-1alpha pathway activation was an important molecular mechanism of exercise resistance against lipotoxic cardiomyopathy.	NAD	151-154	Sirtuin 1	Drosophila melanogaster	113-118
31624074-10	2019	Therefore, we declared that exercise training could improve lipotoxic cardiomyopathy induced by a HFD or cardiac dSir2 knockdown in old Drosophila The NAD+/dSIR2/PGC-1alpha pathway activation was an important molecular mechanism of exercise resistance against lipotoxic cardiomyopathy.	NAD	151-154	Sirtuin 1	Drosophila melanogaster	156-161
31503544-7	2019	Results showed that either cardiac dSir2 overexpression or exercise remarkably increased the cardiac period, systolic interval, diastolic interval, fractional shortening, SOD activity, dSIR2 protein, Foxo, dSir2, Nmnat, and bmm expression levels in the aging flies; they also notably reduced the cardiac triacylglycerol level, malonaldehyde level, and the diastolic dysfunction index.	Triglycerides	304-319	Sirtuin 1	Drosophila melanogaster	35-40
31503544-7	2019	Results showed that either cardiac dSir2 overexpression or exercise remarkably increased the cardiac period, systolic interval, diastolic interval, fractional shortening, SOD activity, dSIR2 protein, Foxo, dSir2, Nmnat, and bmm expression levels in the aging flies; they also notably reduced the cardiac triacylglycerol level, malonaldehyde level, and the diastolic dysfunction index.	Malondialdehyde	327-340	Sirtuin 1	Drosophila melanogaster	35-40
28252007-2	2017	The natural polyphenolic compound resveratrol received renewed interest when recent findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction.	Resveratrol	104-115	Sirtuin 1	Drosophila melanogaster	128-133
28252007-4	2017	It was demonstrated that the SIRT1 activation of resveratrol is affected by the amino acid composition of the substrate.	Resveratrol	49-60	Sirtuin 1	Drosophila melanogaster	29-34
34495320-2	2021	Here, we used Drosophila to identify whether cardiac Nmnat/NAD+/SIR2 pathways activation could mediate endurance exercise resistance to lipotoxic cardiomyopathy.	NAD	59-63	Sirtuin 1	Drosophila melanogaster	64-68
34495320-6	2021	Therefore, current results confirmed that cardiac Nmnat/NAD+/SIR2 pathways were important antagonists of HFD-induced lipotoxic cardiomyopathy.	NAD	56-60	Sirtuin 1	Drosophila melanogaster	61-65
32980539-9	2020	In aged flies, nitrite supplementation significantly downregulated dTOR and upregulated dSir2 gene expression.	Nitrites	15-22	Sirtuin 1	Drosophila melanogaster	88-93
28252007-2	2017	The natural polyphenolic compound resveratrol received renewed interest when recent findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction.	Resveratrol	34-45	Sirtuin 1	Drosophila melanogaster	128-133
27623778-5	2016	Additionally, the Notch-dependent response of several E(spl) genes is sensitive to metabolic stress caused by 2-deoxy-d-glucose treatment, in a Sirt1-dependent manner.	Deoxyglucose	110-127	Sirtuin 1	Drosophila melanogaster	144-149
26538555-7	2016	Furthermore, prunetin-fed males exhibited increased expression of the longevity gene Sirtuin 1 (Sir2) (22%), as well as elevated AMPK activation (51%) and triglyceride levels (29%), whereas glucose levels decreased (36%).	prunetin	13-21	Sirtuin 1	Drosophila melanogaster	85-94
27058248-3	2016	Here we show that loss of the Drosophila SIRT1 homolog sir2 leads to the age-progressive onset of hyperglycemia, obesity, glucose intolerance, and insulin resistance.	Glucose	122-129	Sirtuin 1	Drosophila melanogaster	41-46
27058248-3	2016	Here we show that loss of the Drosophila SIRT1 homolog sir2 leads to the age-progressive onset of hyperglycemia, obesity, glucose intolerance, and insulin resistance.	Glucose	122-129	Sirtuin 1	Drosophila melanogaster	55-59
26538555-7	2016	Furthermore, prunetin-fed males exhibited increased expression of the longevity gene Sirtuin 1 (Sir2) (22%), as well as elevated AMPK activation (51%) and triglyceride levels (29%), whereas glucose levels decreased (36%).	prunetin	13-21	Sirtuin 1	Drosophila melanogaster	96-100
24036492-1	2013	Sir2, a member of the sirtuin family of protein acylases, deacetylates lysine residues within many proteins and is associated with lifespan extension in a variety of model organisms.	Lysine	71-77	Sirtuin 1	Drosophila melanogaster	0-4
26153625-3	2015	Experiments in vitro showed that cAMP directly bound to SIRT1 and SIRT3 and consequently increased their activity.	Cyclic AMP	33-37	Sirtuin 1	Drosophila melanogaster	56-61
24832080-8	2014	Overexpression of SIR2 reduces lifespan variation among different mitochondrial genotypes and further dampens the response of lifespan to CR but not to DR, suggesting that response to these two diets involve different underlying mechanisms.	Chromium	138-140	Sirtuin 1	Drosophila melanogaster	18-22
25335240-6	2014	The restitution time after exposure to anoxia was significantly reduced in Group II (on 31% of the control values) Our results suggest that long-term adaptation to low oxygen partial pressure of highly resistant Drosophila significantly reduces the time of restitution and increases the expression of Sir2 and CG14740 genes.	Oxygen	168-174	Sirtuin 1	Drosophila melanogaster	301-305
24436303-7	2014	Here, we show that highly selective pharmacological inhibition of Drosophila Sir2 and mammalian SirT1 using the novel inhibitor selisistat (selisistat; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide) can suppress HD pathology caused by mutant huntingtin exon 1 fragments in Drosophila, mammalian cells and mice.	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	128-138	Sirtuin 1	Drosophila melanogaster	77-81
24436303-7	2014	Here, we show that highly selective pharmacological inhibition of Drosophila Sir2 and mammalian SirT1 using the novel inhibitor selisistat (selisistat; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide) can suppress HD pathology caused by mutant huntingtin exon 1 fragments in Drosophila, mammalian cells and mice.	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	140-150	Sirtuin 1	Drosophila melanogaster	77-81
24436303-7	2014	Here, we show that highly selective pharmacological inhibition of Drosophila Sir2 and mammalian SirT1 using the novel inhibitor selisistat (selisistat; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide) can suppress HD pathology caused by mutant huntingtin exon 1 fragments in Drosophila, mammalian cells and mice.	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	152-206	Sirtuin 1	Drosophila melanogaster	77-81
23129806-1	2013	Sir2 is an evolutionarily conserved NAD(+)-dependent deacetylase which has been shown to play a critical role in glucose and fat metabolism.	Glucose	113-120	Sirtuin 1	Drosophila melanogaster	0-4
24003736-7	2013	To test the hypothesis that the observed long-term effect of SB exposure on the flies" longevity could be caused by the induction of persistent epigenetic changes, the levels of expression of the longevity-associated genes (hsp70, sir2 and InR) were determined.	Butyric Acid	61-63	Sirtuin 1	Drosophila melanogaster	231-235
24003736-8	2013	The expression level of sir2 gene, known to mediate longevity in the fly through a pathway related to calorie restriction, in the group treated at the larval stage with 20 mmol/l SB was significantly higher after the stress (starvation) than in the control group.	Butyric Acid	179-181	Sirtuin 1	Drosophila melanogaster	24-28
23325575-8	2013	In addition, THC extended lifespan in Drosophila and inhibited the oxidative stress response by regulating FOXO and Sir2.	tetrahydrocurcumin	13-16	Sirtuin 1	Drosophila melanogaster	116-120
23129806-6	2013	By genetic perturbations and metabolic rescue, we provide evidence to illustrate that fat body dSir2 mediates its effects on the muscles via free fatty acids (FFA) and dILPs (from the insulin-producing cells [IPCs]).	Fatty Acids, Nonesterified	141-157	Sirtuin 1	Drosophila melanogaster	95-100
22411915-1	2012	Sir2 is an evolutionarily conserved NAD+ dependent protein.	NAD	36-40	Sirtuin 1	Drosophila melanogaster	0-4
22610403-7	2012	Moreover, recent Drosophila genetic analyses demonstrate that the neuroprotective molecules Sir2 and FOXO specifically complement mitochondrial dysfunction and DA neuron loss in PINK1 null mutants, suggesting that Sir2 and FOXO protect mitochondria and DA neurons downstream of PINK1.	Dopamine	160-162	Sirtuin 1	Drosophila melanogaster	92-96
22610403-7	2012	Moreover, recent Drosophila genetic analyses demonstrate that the neuroprotective molecules Sir2 and FOXO specifically complement mitochondrial dysfunction and DA neuron loss in PINK1 null mutants, suggesting that Sir2 and FOXO protect mitochondria and DA neurons downstream of PINK1.	Dopamine	253-255	Sirtuin 1	Drosophila melanogaster	92-96
22610403-7	2012	Moreover, recent Drosophila genetic analyses demonstrate that the neuroprotective molecules Sir2 and FOXO specifically complement mitochondrial dysfunction and DA neuron loss in PINK1 null mutants, suggesting that Sir2 and FOXO protect mitochondria and DA neurons downstream of PINK1.	Dopamine	253-255	Sirtuin 1	Drosophila melanogaster	214-218
22411915-2	2012	Although, SIRT1 has been implicated to be a key regulator of fat and glucose metabolism in mammals, the role of Sir2 in regulating organismal physiology, in invertebrates, is unclear.	Glucose	69-76	Sirtuin 1	Drosophila melanogaster	10-15
20157536-6	2009	Similarly, increasing dSir2 activity by feeding flies resveratrol, a CR mimetic, increases spontaneous physical activity of flies on high caloric food.	Resveratrol	54-65	Sirtuin 1	Drosophila melanogaster	22-27
21596603-2	2011	The NAD(+)-dependent deacetylase and gene repressor SIRT1 removes histone H4K16 acetylation marks and facilitates heterochromatin formation.	NAD	4-10	Sirtuin 1	Drosophila melanogaster	52-57
21325893-4	2011	Here we show that a pathway centric approach can be used to identify shared physiological pathways between DR and Sir2, p53 and resveratrol life span extending interventions.	Resveratrol	128-139	Sirtuin 1	Drosophila melanogaster	114-118
22156377-8	2011	Based on these results, THC may regulate the aging process via an evolutionarily conserved signaling pathway that includes both foxo and Sir2.	tetrahydrocurcumin	24-27	Sirtuin 1	Drosophila melanogaster	137-141
21085633-11	2010	Surprisingly, although Sir2 is typically upregulated under conditions of starvation, Sir2 mutant larvae survive better than wild type under conditions of amino-acid starvation as long as sugars are provided.	Sugars	187-193	Sirtuin 1	Drosophila melanogaster	85-89
21085633-12	2010	Our findings point to a Sir2-mediated pathway that activates a catabolic response to amino-acid starvation irrespective of the sugar content of the diet.	Sugars	127-132	Sirtuin 1	Drosophila melanogaster	24-28
18762557-4	2008	We also find that among the NAD(+)-dependent class III deacetylases, genetic or pharmacological reduction of either Sir2 or Sirt2 provides neuroprotection to Htt-challenged animals and that even greater neuroprotection is achieved when Rpd3 and Sir2 are simultaneously reduced.	NAD	28-32	Sirtuin 1	Drosophila melanogaster	116-120
19851477-0	2009	dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster.	Chromium	47-49	Sirtuin 1	Drosophila melanogaster	0-5
19851477-2	2009	In the fruit fly D. melanogaster, CR is mediated at least in part by activation of dSir2.	Chromium	34-36	Sirtuin 1	Drosophila melanogaster	83-88
19851477-10	2009	Taken together, our data demonstrate that Dmp53 is a down stream target of dSir2 enzymatic activity and mediates some aspects of the life span extending effects of CR.	Chromium	164-166	Sirtuin 1	Drosophila melanogaster	75-80
19049465-0	2008	Highly dissociative and concerted mechanism for the nicotinamide cleavage reaction in Sir2Tm enzyme suggested by ab initio QM/MM molecular dynamics simulations.	Niacinamide	52-64	Sirtuin 1	Drosophila melanogaster	86-90
19049465-1	2008	Sir2 enzymes catalyze the NAD+-dependent protein deacetylation and play critical roles in epigenetics, cell death, and lifespan regulation.	NAD	26-30	Sirtuin 1	Drosophila melanogaster	0-4
18678867-3	2008	PNC1 is thought to exert its effect on yeast life span by modulating cellular nicotinamide and NAD levels, resulting in increased activity of Sir2 family class III histone deacetylases.	Niacinamide	78-90	Sirtuin 1	Drosophila melanogaster	142-146