PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
28069903-4	2017	Interestingly, immunofluorescence analysis demonstrated that coa-A induced heat shock protein 70 (HSP70) and phosphatidylinositol-3-kinase (PI3K), but significantly attenuated nuclear factor kappa B (NF-kappaB) and cyclooxygenase-2 (COX2).	coa-a	61-66	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	109-138
32464193-5	2020	Vaccarin stimulated these signaling pathways via the Prl receptor-phosphatidyl inositol 3-kinase (PI3K) signaling.	vaccarin H	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	57-96
30259565-5	2018	Our results showed that NaB treatment increased the phosphoinositide 3-kinase (PI3K) and phospho-AKT (P-AKT) protein levels, whereas it decreased the Bax, caspase-3, and caspase-9 protein levels in LPS-induced MAC-T cells.	nab	24-27	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	52-77
17395704-0	2007	Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Galphai protein-dependent activation of phosphatidylinositol 3-kinase/Akt and regulation of antiapoptotic Bcl-2 expression.	Dehydroepiandrosterone	0-22	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	127-156
20410596-7	2010	Our biochemical assays indicated that alpha-chaconine potently suppressed the phosphorylation of c-Jun N-terminal kinase (JNK), phosphatidylinositide-3 kinase (PI3K) and Akt, while it did not affect phosphorylation of extracellular signal regulating kinase (ERK) and p38.	alpha-chaconine	38-53	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	128-158
18161856-3	2008	This action of IGF-I to block heat shock-induced apoptosis was eliminated if embryos were cultured with either a phosphatidylinositol 3-kinase (PI3K) inhibitor (wortmannin) or an Akt inhibitor (1L-6-hydroxymethyl-chiro-inositol 2-(R)-2-o-methyl-3-o-octadecylcarbonate).	Wortmannin	161-171	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	113-142
17395704-4	2007	DHEA stimulation of bovine aortic endothelial cells resulted in rapid and dose-dependent phosphorylation of Akt, which was blocked by LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), the upstream kinase of Akt.	Dehydroepiandrosterone	0-4	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	168-197
17395704-4	2007	DHEA stimulation of bovine aortic endothelial cells resulted in rapid and dose-dependent phosphorylation of Akt, which was blocked by LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K), the upstream kinase of Akt.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	134-142	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	168-197
15634940-2	2005	Because of the known signaling pathways for IL-4 and importance of calcium uptake in maintaining SR calcium stores shared by agonists and caffeine, it was hypothesized that this rapid inhibitory effect might depend on phosphatidylinositol 3-kinase (PI3K) and on inhibition of calcium uptake by the SR. Enzyme-dispersed bovine trachealis cells were loaded with Fura-2/acetoxymethyl ester, and changes in cytosolic calcium were imaged in single cells.	Caffeine	138-146	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	218-247
16800627-5	2006	siRNA-mediated Gbeta1 knockdown markedly and specifically potentiates insulin-dependent activation of kinase Akt, likely reflecting the removal of the inhibitory effect of Gbetagamma on PI3-Kalpha activity.	gbetagamma	172-182	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	186-196
15634940-2	2005	Because of the known signaling pathways for IL-4 and importance of calcium uptake in maintaining SR calcium stores shared by agonists and caffeine, it was hypothesized that this rapid inhibitory effect might depend on phosphatidylinositol 3-kinase (PI3K) and on inhibition of calcium uptake by the SR. Enzyme-dispersed bovine trachealis cells were loaded with Fura-2/acetoxymethyl ester, and changes in cytosolic calcium were imaged in single cells.	Fura-2	360-366	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	218-247
15634940-2	2005	Because of the known signaling pathways for IL-4 and importance of calcium uptake in maintaining SR calcium stores shared by agonists and caffeine, it was hypothesized that this rapid inhibitory effect might depend on phosphatidylinositol 3-kinase (PI3K) and on inhibition of calcium uptake by the SR. Enzyme-dispersed bovine trachealis cells were loaded with Fura-2/acetoxymethyl ester, and changes in cytosolic calcium were imaged in single cells.	acetoxymethyl ester	367-386	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	218-247
12757411-3	2003	The phosphorylation was completely abolished by pretreatment of the cells with a phosphoinositide 3-kinase (PI3K) inhibitor (wortmannin) and by transfection of dominant-negative Akt, and the enzyme activity was inhibited by wortmannin.	Wortmannin	125-135	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	81-106
14742683-6	2004	Vanadate activates the phosphoinositide3-kinase (PI3-K)/Akt pathway, which is known to increase endothelial NOS (eNOS) activity by direct phosphorylation of Ser-1179.	Vanadates	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	23-47
14742683-6	2004	Vanadate activates the phosphoinositide3-kinase (PI3-K)/Akt pathway, which is known to increase endothelial NOS (eNOS) activity by direct phosphorylation of Ser-1179.	Serine	157-160	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	23-47
14588144-3	2003	The increases of DNA fragmentation, Bax/Bcl-2 ratio, and caspase activities were abrogated by BAPTA-AM (an intracellular Ca(2+) chelator) and N-acetyl-L-cysteine (an antioxidant), and augmented by wortmannin [a phosphatidylinositol 3-kinase (PI3K) inhibitor].	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester	94-102	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	211-240
14588144-3	2003	The increases of DNA fragmentation, Bax/Bcl-2 ratio, and caspase activities were abrogated by BAPTA-AM (an intracellular Ca(2+) chelator) and N-acetyl-L-cysteine (an antioxidant), and augmented by wortmannin [a phosphatidylinositol 3-kinase (PI3K) inhibitor].	Acetylcysteine	142-161	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	211-240
12757411-3	2003	The phosphorylation was completely abolished by pretreatment of the cells with a phosphoinositide 3-kinase (PI3K) inhibitor (wortmannin) and by transfection of dominant-negative Akt, and the enzyme activity was inhibited by wortmannin.	Wortmannin	224-234	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	81-106
12639717-4	2003	(3) The phosphatidylinositol 3-kinase (PI3K) inhibitor wortmannin (Wo) triggered apoptosis and enhanced the TNF-induced cell death.	Wortmannin	55-65	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	8-37
11939794-6	2002	In BAEC, activation of eNOS by LPA is completely blocked by pertussis toxin, by the intracellular calcium chelator BAPTA (1,2-bis(aminophenoxy) ethane-N,N,N",N"-tetraacetic acid), and by the phosphoinositide 3-kinase (PI3-K) inhibitor wortmannin, but is unaffected by U0126, an inhibitor of mitogen-activated protein (MAP) kinase pathways.	lysophosphatidic acid	31-34	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	191-216
12054696-7	2002	Phosphatidylinositol 3-kinase (PI3K) inhibitors, wortmannin and LY294002, blocked not only p38 MAPK activation but also Rac activation.	Wortmannin	49-59	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	0-29
12054696-7	2002	Phosphatidylinositol 3-kinase (PI3K) inhibitors, wortmannin and LY294002, blocked not only p38 MAPK activation but also Rac activation.	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	64-72	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	0-29
11939794-6	2002	In BAEC, activation of eNOS by LPA is completely blocked by pertussis toxin, by the intracellular calcium chelator BAPTA (1,2-bis(aminophenoxy) ethane-N,N,N",N"-tetraacetic acid), and by the phosphoinositide 3-kinase (PI3-K) inhibitor wortmannin, but is unaffected by U0126, an inhibitor of mitogen-activated protein (MAP) kinase pathways.	Calcium	98-105	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	191-216
11939794-6	2002	In BAEC, activation of eNOS by LPA is completely blocked by pertussis toxin, by the intracellular calcium chelator BAPTA (1,2-bis(aminophenoxy) ethane-N,N,N",N"-tetraacetic acid), and by the phosphoinositide 3-kinase (PI3-K) inhibitor wortmannin, but is unaffected by U0126, an inhibitor of mitogen-activated protein (MAP) kinase pathways.	1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid	115-120	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	191-216
11726610-10	2001	Immunoprecipitates of PY-ROS and N-ROS with anti-IRbeta antibodies, probed with anti-p85 and anti-p110alpha antibodies, indicated increased amounts of both p85 and p110alpha in PY-ROS compared to N-ROS.	py-ros	22-28	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	164-173
11726610-10	2001	Immunoprecipitates of PY-ROS and N-ROS with anti-IRbeta antibodies, probed with anti-p85 and anti-p110alpha antibodies, indicated increased amounts of both p85 and p110alpha in PY-ROS compared to N-ROS.	n-ros	33-38	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	164-173
11726610-10	2001	Immunoprecipitates of PY-ROS and N-ROS with anti-IRbeta antibodies, probed with anti-p85 and anti-p110alpha antibodies, indicated increased amounts of both p85 and p110alpha in PY-ROS compared to N-ROS.	py-ros	177-183	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	164-173
11726610-10	2001	Immunoprecipitates of PY-ROS and N-ROS with anti-IRbeta antibodies, probed with anti-p85 and anti-p110alpha antibodies, indicated increased amounts of both p85 and p110alpha in PY-ROS compared to N-ROS.	n-ros	196-201	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	164-173
10842153-3	2000	Phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) are two enzymes that have been associated with VSMC migration.	vsmc	111-115	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	0-29
11668060-6	2001	Because lysophosphatidic acid (LPA) has been proposed to be responsible for this activity of PCM and is known to activate the G(i) protein, inhibitors of the G protein pertussis toxin and of the associated phosphatidylinositol 3-kinase (PI3K) wortmannin were used.	lysophosphatidic acid	8-29	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	206-235
11668060-6	2001	Because lysophosphatidic acid (LPA) has been proposed to be responsible for this activity of PCM and is known to activate the G(i) protein, inhibitors of the G protein pertussis toxin and of the associated phosphatidylinositol 3-kinase (PI3K) wortmannin were used.	lysophosphatidic acid	31-34	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	206-235
11063755-8	2000	RESULTS: PI 3-kinase activity in anti-p85 and p110alpha IPs was significantly higher in PY-ROS than in N-ROS.	py-ros	88-94	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	46-55
11063755-8	2000	RESULTS: PI 3-kinase activity in anti-p85 and p110alpha IPs was significantly higher in PY-ROS than in N-ROS.	n-ros	103-108	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	46-55
11063755-12	2000	However, tyrosine phosphorylation of p85 and p110alpha was not observed in anti-p85 and anti-p110alpha IPs that were probed with anti-PY.	Tyrosine	9-17	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	45-54
11063755-13	2000	CONCLUSIONS: This study indicates that the p85/p110alpha complex of PI 3-kinase is present in ROS and tyrosine phosphorylation is involved in the regulation of its activity.	Tyrosine	102-110	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Bos taurus	47-56