PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
9949891-1	1998	Pituitary adenylate cyclase-activating polypeptide (PACAP) has been originally isolated from the sheep hypothalamus on the basis of its ability to stimulate cAMP formation in anterior pituitary cells.	Cyclic AMP	157-161	pituitary adenylate cyclase-activating polypeptide	Ovis aries	0-58
15869565-11	2005	These observations, together with previous in vivo studies, suggest that PACAP could act directly on TIDA neurones via PAC1R to increase dopamine release and consequently inhibit prolactin secretion in the sheep.	tida neurones	101-114	pituitary adenylate cyclase-activating polypeptide	Ovis aries	73-78
15869565-11	2005	These observations, together with previous in vivo studies, suggest that PACAP could act directly on TIDA neurones via PAC1R to increase dopamine release and consequently inhibit prolactin secretion in the sheep.	Dopamine	137-145	pituitary adenylate cyclase-activating polypeptide	Ovis aries	73-78
9809798-8	1998	Both the intravenous background infusion of atropine at 10 nmol/kg/min and the reversible cooling blockade of the bilateral cervical vagus nerves blocked the effect of PACAP-27.	Atropine	44-52	pituitary adenylate cyclase-activating polypeptide	Ovis aries	168-173
9441267-1	1997	Pituitary adenylate cyclase activating polypeptide was first isolated from sheep hypothalamus by its potent activity in stimulating cyclic adenosine monophosphate production in anterior pituitary cells.	Cyclic AMP	132-162	pituitary adenylate cyclase-activating polypeptide	Ovis aries	0-50
9593986-0	1998	PACAP stimulates dopamine neuronal activity in the medial basal hypothalamus and inhibits prolactin.	Dopamine	17-25	pituitary adenylate cyclase-activating polypeptide	Ovis aries	0-5
9593986-1	1998	In sheep intracerebroventricular injection of PACAP (10 nmol) significantly (P<0.01) stimulated the levels of the dopamine metabolite DOPAC within the medial basal hypothalamus (as measured by in vivo microdialysis) and this effect was temporally correlated with a significant (P<0.05) suppression in peripheral prolactin concentrations.	Dopamine	117-125	pituitary adenylate cyclase-activating polypeptide	Ovis aries	46-51
9593986-1	1998	In sheep intracerebroventricular injection of PACAP (10 nmol) significantly (P<0.01) stimulated the levels of the dopamine metabolite DOPAC within the medial basal hypothalamus (as measured by in vivo microdialysis) and this effect was temporally correlated with a significant (P<0.05) suppression in peripheral prolactin concentrations.	3,4-Dihydroxyphenylacetic Acid	137-142	pituitary adenylate cyclase-activating polypeptide	Ovis aries	46-51
9593986-2	1998	This result is in accord with the hypothesis that PACAP suppresses prolactin secretion from the anterior pituitary gland by stimulating dopamine release from tuberoinfundibular dopaminergic neurons.	Dopamine	136-144	pituitary adenylate cyclase-activating polypeptide	Ovis aries	50-55
9375356-5	1996	PACAP-27 and VIP increased pancreatic juice flow and bicarbonate output dose-dependently; however, the responses to the highest dose were not altered significantly by atropine.	Bicarbonates	53-64	pituitary adenylate cyclase-activating polypeptide	Ovis aries	0-5
9147291-15	1997	However, at a high concentration (1 mumol/l), PACAP inhibited the GH response to GHRH.	ghrh	81-85	pituitary adenylate cyclase-activating polypeptide	Ovis aries	46-51
27681724-9	2016	Pituitary adenylate cyclase-activating polypeptide (PACAP) is a hypothalamic peptide that was first isolated from sheep hypothalamic extracts based on its ability to stimulate cAMP production in anterior pituitary cells.	Cyclic AMP	176-180	pituitary adenylate cyclase-activating polypeptide	Ovis aries	0-50
8778233-6	1996	The VIP antagonist [4Cl-D-Phe6,Leu17]VIP had no effect on the cAMP response to either PACAP or VIP while the peptide PACAP(6-38), a putative PACAP antagonist, blocked the cAMP response to PACAP.	Cyclic AMP	171-175	pituitary adenylate cyclase-activating polypeptide	Ovis aries	117-122
8778233-6	1996	The VIP antagonist [4Cl-D-Phe6,Leu17]VIP had no effect on the cAMP response to either PACAP or VIP while the peptide PACAP(6-38), a putative PACAP antagonist, blocked the cAMP response to PACAP.	Cyclic AMP	171-175	pituitary adenylate cyclase-activating polypeptide	Ovis aries	117-122
8778233-6	1996	The VIP antagonist [4Cl-D-Phe6,Leu17]VIP had no effect on the cAMP response to either PACAP or VIP while the peptide PACAP(6-38), a putative PACAP antagonist, blocked the cAMP response to PACAP.	Cyclic AMP	171-175	pituitary adenylate cyclase-activating polypeptide	Ovis aries	117-122
32561449-1	2020	Pituitary adenylate cyclase-activating polypeptide (PACAP) is an ancestral molecule that was isolated from sheep hypothalamic extracts based on its action to stimulate cAMP production by pituitary cell cultures.	Cyclic AMP	168-172	pituitary adenylate cyclase-activating polypeptide	Ovis aries	0-50
32561449-1	2020	Pituitary adenylate cyclase-activating polypeptide (PACAP) is an ancestral molecule that was isolated from sheep hypothalamic extracts based on its action to stimulate cAMP production by pituitary cell cultures.	Cyclic AMP	168-172	pituitary adenylate cyclase-activating polypeptide	Ovis aries	52-57
8778233-4	1996	PACAP dose-dependently stimulated intracellular cAMP levels with a half-maximum response at 2.9 +/- 0.2 nmol/l (n = 4).	Cyclic AMP	48-52	pituitary adenylate cyclase-activating polypeptide	Ovis aries	0-5
27681724-9	2016	Pituitary adenylate cyclase-activating polypeptide (PACAP) is a hypothalamic peptide that was first isolated from sheep hypothalamic extracts based on its ability to stimulate cAMP production in anterior pituitary cells.	Cyclic AMP	176-180	pituitary adenylate cyclase-activating polypeptide	Ovis aries	52-57
26172184-11	2015	In PACAP-related pancreatic activities, a modulatory role of galanin, SP and to a lower extend of CRF is also likely.	TFF2 protein, human	70-72	pituitary adenylate cyclase-activating polypeptide	Ovis aries	3-8