PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 32424728-9 2020 Moreover, the significant module genes in PPI networks were Cmya1, Casq2, Cmya5, Ttn, Csrp3 and Actc1, and one existing drug, DEXAMETHASONE, have targeted to Actc1 gene. Dexamethasone 126-139 actin alpha cardiac muscle 1 Homo sapiens 158-163 34434217-5 2021 Finally, survival analysis of these hub genes found that three of them (CCNB1, ASPM, and ACTC1) were conspicuously related to the prognosis of patients with BTCC (p < 0.05). S-Butyrylthiocholine chloride 157-161 actin alpha cardiac muscle 1 Homo sapiens 89-94 35223984-2 2021 Objective: The aim of this study was to search the prognostic biomarkers of EOC and to investigate the expression of G protein-coupled receptor kinase 5 (GRK5) and actin alpha cardiac muscle 1 (ACTC1) in EOC tissues (both paraffin-embedded and fresh-frozen tissues) and to explore their association with clinicopathological parameters and prognostic value in patients with EOC. Paraffin 222-230 actin alpha cardiac muscle 1 Homo sapiens 164-192 35223984-2 2021 Objective: The aim of this study was to search the prognostic biomarkers of EOC and to investigate the expression of G protein-coupled receptor kinase 5 (GRK5) and actin alpha cardiac muscle 1 (ACTC1) in EOC tissues (both paraffin-embedded and fresh-frozen tissues) and to explore their association with clinicopathological parameters and prognostic value in patients with EOC. Paraffin 222-230 actin alpha cardiac muscle 1 Homo sapiens 194-199 34884505-5 2021 Histone deacetylase (HDAC) activity in dilated hmMSCs was 1.5-fold higher than in healthy ones, which was suppressed by class I and II HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) showing activation of cardiomyogenic differentiation-related genes alpha-cardiac actin (ACTC1) and cardiac troponin T (TNNT2). Vorinostat 150-181 actin alpha cardiac muscle 1 Homo sapiens 277-282 34884505-6 2021 Both types of hmMSCs cultivated on collagen I hydrogels with hyaluronic acid (HA) or 2-methacryloyloxyethyl phosphorylcholine (MPC) and exposed to SAHA significantly downregulated focal adhesion kinase (PTK2) and activated ACTC1 and TNNT2. Hyaluronic Acid 61-76 actin alpha cardiac muscle 1 Homo sapiens 223-228 34884505-6 2021 Both types of hmMSCs cultivated on collagen I hydrogels with hyaluronic acid (HA) or 2-methacryloyloxyethyl phosphorylcholine (MPC) and exposed to SAHA significantly downregulated focal adhesion kinase (PTK2) and activated ACTC1 and TNNT2. Hyaluronic Acid 78-80 actin alpha cardiac muscle 1 Homo sapiens 223-228 34884505-6 2021 Both types of hmMSCs cultivated on collagen I hydrogels with hyaluronic acid (HA) or 2-methacryloyloxyethyl phosphorylcholine (MPC) and exposed to SAHA significantly downregulated focal adhesion kinase (PTK2) and activated ACTC1 and TNNT2. 2-methacryloyloxyethyl phosphorylcholine 85-125 actin alpha cardiac muscle 1 Homo sapiens 223-228 34884505-6 2021 Both types of hmMSCs cultivated on collagen I hydrogels with hyaluronic acid (HA) or 2-methacryloyloxyethyl phosphorylcholine (MPC) and exposed to SAHA significantly downregulated focal adhesion kinase (PTK2) and activated ACTC1 and TNNT2. 2-methacryloyloxyethyl phosphorylcholine 127-130 actin alpha cardiac muscle 1 Homo sapiens 223-228 32531470-11 2020 Calcium transient abnormalities were rescued with combination of dantrolene and ranolazine, whilst mavacamten reduced the hyper-contractile phenotype of p.ACTC1-E99K hiPSC-CMs. MYK-461 99-109 actin alpha cardiac muscle 1 Homo sapiens 155-160 31434612-5 2019 Mechanistically, we found reduced GTP-bound Rho-GTPase and increased nuclear localization of globular actin in NRVCMs overexpressing mutant ACTC1 possibly causing inhibition of SRF-signaling activation. Guanosine Triphosphate 34-37 actin alpha cardiac muscle 1 Homo sapiens 140-145 28756295-10 2017 In conclusion, given that ACTC1 upregulation is associated with improved muscle function in certain myopathies, we hypothesise that upregulation of ACTC1 may represent a compensatory response to ADT-induced muscle loss. adt 195-198 actin alpha cardiac muscle 1 Homo sapiens 148-153 27081897-4 2017 METHODS mRNA expression of ACTC1 expression was analyzed using quantitative real-time polymerase chain reaction (qRT-PCR) in 47 formalin-fixed, paraffin-embedded glioma tissues that were graded according to WHO criteria: Grade I (n = 4); Grade II (n = 12); Grade III (n = 6); and Grade IV (n = 25). Formaldehyde 128-136 actin alpha cardiac muscle 1 Homo sapiens 27-32 27081897-4 2017 METHODS mRNA expression of ACTC1 expression was analyzed using quantitative real-time polymerase chain reaction (qRT-PCR) in 47 formalin-fixed, paraffin-embedded glioma tissues that were graded according to WHO criteria: Grade I (n = 4); Grade II (n = 12); Grade III (n = 6); and Grade IV (n = 25). Paraffin 144-152 actin alpha cardiac muscle 1 Homo sapiens 27-32 20962418-4 2010 Also, as shown by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay, the proportion of apoptotic cardiomyocytes in samples featuring down-regulated ACTC1 expression (Group 1) was significantly greater than those with normal expression (Group 2) and the controls (P<0.01). deoxyuridine triphosphate 65-69 actin alpha cardiac muscle 1 Homo sapiens 182-187