PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
22935107-2	2013	We aimed to determine the CNS sites and receptors that mediate the anorectic effects of peripherally administered PK2 and its chronic effects on glucose and energy homeostasis.	Glucose	145-152	prokineticin 2	Mus musculus	114-117
25194046-7	2014	A putative neurochemical output signal of the SCN, prokineticin 2 (PK2), inhibited some LHb neurones by elevating the frequency of GABA release in the LHb.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	88-91	prokineticin 2	Mus musculus	51-65
25194046-7	2014	A putative neurochemical output signal of the SCN, prokineticin 2 (PK2), inhibited some LHb neurones by elevating the frequency of GABA release in the LHb.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	88-91	prokineticin 2	Mus musculus	67-70
25194046-7	2014	A putative neurochemical output signal of the SCN, prokineticin 2 (PK2), inhibited some LHb neurones by elevating the frequency of GABA release in the LHb.	gamma-Aminobutyric Acid	131-135	prokineticin 2	Mus musculus	51-65
25194046-7	2014	A putative neurochemical output signal of the SCN, prokineticin 2 (PK2), inhibited some LHb neurones by elevating the frequency of GABA release in the LHb.	gamma-Aminobutyric Acid	131-135	prokineticin 2	Mus musculus	67-70
25194046-7	2014	A putative neurochemical output signal of the SCN, prokineticin 2 (PK2), inhibited some LHb neurones by elevating the frequency of GABA release in the LHb.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	151-154	prokineticin 2	Mus musculus	51-65
25194046-7	2014	A putative neurochemical output signal of the SCN, prokineticin 2 (PK2), inhibited some LHb neurones by elevating the frequency of GABA release in the LHb.	5-[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]methylamino]methyl]-4-Azanyl-1-(Methoxymethyl)pyrimidin-2-One	151-154	prokineticin 2	Mus musculus	67-70
24902717-5	2014	Expression and localization of PROK2 and of its receptors at peripheral and central level was evaluated 10 days after CCI, following treatment for 1 week with saline or PC1.	Sodium Chloride	159-165	prokineticin 2	Mus musculus	31-36
25434589-3	2015	Prokineticins (PKs), which include PK1 and PK2, represent a novel family of chemokines characterized by a unique structural motif comprising five disulfide bonds.	Disulfides	146-155	prokineticin 2	Mus musculus	43-46
24957319-0	2014	Anti-Bv8 antibody and metronomic gemcitabine improve pancreatic adenocarcinoma treatment outcome following weekly gemcitabine therapy.	gemcitabine	114-125	prokineticin 2	Mus musculus	5-8
24957319-5	2014	Furthermore, Bv8 is highly expressed in MDSCs colonizing pancreatic tumors in mice treated with weekly gemcitabine compared to MC gemcitabine or the combination of the two regimens.	gemcitabine	103-114	prokineticin 2	Mus musculus	13-16
24957319-6	2014	Blocking Bv8 with antibodies in weekly gemcitabine-treated mice results in a significant reduction in tumor regrowth, angiogenesis, and metastasis.	gemcitabine	39-50	prokineticin 2	Mus musculus	9-12
24957319-7	2014	Overall, our results suggest that pro-tumorigenic effects induced by weekly gemcitabine are mediated in part by MDSCs expressing Bv8.	gemcitabine	76-87	prokineticin 2	Mus musculus	129-132
24957319-8	2014	Therefore, both Bv8 inhibition and MC can be used as legitimate "add-on" treatments for preventing post-chemotherapy pancreatic cancer recurrence, progression, and metastasis following weekly gemcitabine therapy.	gemcitabine	192-203	prokineticin 2	Mus musculus	16-19
22935107-6	2013	The effect of IP PK2 administration on glucose homeostasis was investigated.	Glucose	39-46	prokineticin 2	Mus musculus	17-20
22960406-4	2012	The PK2 expression was rapidly induced in the hypothalamic paraventricular nucleus (PVN) after fasting, which can be mimicked by 2-deoxy-D-glucose (2-DG) injection.	Deoxyglucose	129-146	prokineticin 2	Mus musculus	4-7
22960406-4	2012	The PK2 expression was rapidly induced in the hypothalamic paraventricular nucleus (PVN) after fasting, which can be mimicked by 2-deoxy-D-glucose (2-DG) injection.	Deoxyglucose	148-152	prokineticin 2	Mus musculus	4-7
22122547-5	2012	EXPERIMENTAL APPROACH: We modified the Bv8 molecule by substituting Trp in position 24 with Ala (A-24) and compared it with Bv8 for binding and activating PK(1) and PK(2) receptors in cell preparations and in affecting nociceptive thresholds in rodents.	Tryptophan	68-71	prokineticin 2	Mus musculus	39-42
22122547-5	2012	EXPERIMENTAL APPROACH: We modified the Bv8 molecule by substituting Trp in position 24 with Ala (A-24) and compared it with Bv8 for binding and activating PK(1) and PK(2) receptors in cell preparations and in affecting nociceptive thresholds in rodents.	Alanine	92-95	prokineticin 2	Mus musculus	39-42
21882405-12	2004	(6) evaluated [(18)F]PC-10 binding in mice injected with complete Freund adjuvant (CFA) to induce inflammatory pain by upregulation of PK2 and PKR1.	complete freund adjuvant	57-81	prokineticin 2	Mus musculus	135-138
22333836-6	2012	In addition, we found GTP-bound active form of nuclear RhoA was decreased in Pk2(-/-) embryos during compaction.	Guanosine Triphosphate	22-25	prokineticin 2	Mus musculus	77-80
21882405-12	2004	(6) evaluated [(18)F]PC-10 binding in mice injected with complete Freund adjuvant (CFA) to induce inflammatory pain by upregulation of PK2 and PKR1.	3-chloro-4-fluoroaniline	83-86	prokineticin 2	Mus musculus	135-138
21886578-2	2011	Recently, we detected the significant association between prokineticin 2 receptor gene (PROKR2) and Japanese methamphetamine dependence patients.	Methamphetamine	109-124	prokineticin 2	Mus musculus	58-72
21722394-8	2011	Cyclophosphamide-induced diabetes at 10 weeks post-B cell reconstitution reorganized the predominant TCR repertoires by removing potential regulatory clonotypes (BV1, BV8 and BV11) and increasing the frequency of others (BV4, BV5S2, BV9, BV16-20).	Cyclophosphamide	0-16	prokineticin 2	Mus musculus	167-170
21886578-3	2011	Also, prokineticin 2 (PK2) gene deficient mice showed reduced physiological and behavioral parameters, including circadian locomotor activity, circulating glucocorticoid, glucose levels and the expression of peripheral clock genes compared with WT mice.	Glucose	171-178	prokineticin 2	Mus musculus	6-20
21886578-3	2011	Also, prokineticin 2 (PK2) gene deficient mice showed reduced physiological and behavioral parameters, including circadian locomotor activity, circulating glucocorticoid, glucose levels and the expression of peripheral clock genes compared with WT mice.	Glucose	171-178	prokineticin 2	Mus musculus	22-25
16901473-4	2006	Increases in Ca2+ levels by PK-2 were diminished by U73122 (a phospholipase C inhibitor).	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	52-58	prokineticin 2	Mus musculus	28-32
19667192-2	2009	Bv8/prokineticin 2 (PK2), a chemokine characterized by a unique structural motif comprising five disulfide bonds, is highly expressed in inflamed tissues associated to infiltrating cells.	Disulfides	97-106	prokineticin 2	Mus musculus	0-3
19667192-2	2009	Bv8/prokineticin 2 (PK2), a chemokine characterized by a unique structural motif comprising five disulfide bonds, is highly expressed in inflamed tissues associated to infiltrating cells.	Disulfides	97-106	prokineticin 2	Mus musculus	4-18
19667192-2	2009	Bv8/prokineticin 2 (PK2), a chemokine characterized by a unique structural motif comprising five disulfide bonds, is highly expressed in inflamed tissues associated to infiltrating cells.	Disulfides	97-106	prokineticin 2	Mus musculus	20-23
17959774-7	2007	Two brothers with KS and their sister with nIHH harbored a homozygous deletion in the PROK2 gene (p.[I55fsX1]+[I55fsX1]).	nihh	43-47	prokineticin 2	Mus musculus	86-91
17959774-11	2007	Homozygous loss-of-function PROK2 mutations cause both KS and nIHH.	nihh	62-66	prokineticin 2	Mus musculus	28-33
17634381-7	2007	Daily treatment with Alprazolam reversed the dysregulated expression of Per2 and also Prok2, an output factor of the SCN that controls behavioral rhythms.	Alprazolam	21-31	prokineticin 2	Mus musculus	86-91
17107623-7	2006	PK2 mobilizes calcium in dissociated dorsal root ganglion (DRG) neurons.	Calcium	14-21	prokineticin 2	Mus musculus	0-3
17107623-8	2006	Mice lacking the PK2 gene displayed strong reduction in nociception induced by thermal and chemical stimuli, including capsaicin.	Capsaicin	119-128	prokineticin 2	Mus musculus	17-20
17107623-10	2006	As the majority of PK2-responsive DRG neurons also expressed transient receptor potential vanilloid (TRPV1) and exhibited sensitivity to capsaicin, TRPV1 is likely a significant downstream molecule of PK2 signaling.	Capsaicin	137-146	prokineticin 2	Mus musculus	19-22
17107623-10	2006	As the majority of PK2-responsive DRG neurons also expressed transient receptor potential vanilloid (TRPV1) and exhibited sensitivity to capsaicin, TRPV1 is likely a significant downstream molecule of PK2 signaling.	Capsaicin	137-146	prokineticin 2	Mus musculus	201-204
17093083-7	2006	PK2-null mice also displayed significantly reduced rhythmicity for a variety of other physiological and behavioral parameters, including sleep-wake cycle, body temperature, circulating glucocorticoid and glucose levels, as well as the expression of peripheral clock genes.	Glucose	204-211	prokineticin 2	Mus musculus	0-3
34769347-5	2021	BTZ treatment promoted a precocious upregulation of KDM6A, PPARs, and IL-6, and a delayed increase of PK2 and IL-1beta.	Bortezomib	0-3	prokineticin 2	Mus musculus	102-105
9190955-7	1997	Furthermore, EAMG in TCR transgenic mice was prevented by treatment with mAb to TCRBV8, which depleted BV8-expressing T cells.	eamg	13-17	prokineticin 2	Mus musculus	83-86
34970418-0	2021	Trehalose Ameliorates Diabetic Cardiomyopathy: Role of the PK2/PKR Pathway.	Trehalose	0-9	prokineticin 2	Mus musculus	59-62
16299550-8	2006	5.--Effects on chemotaxis and cytokine are not pertussis-toxin sensitive, but are completely prevented by addition of the phospholipase inhibitor U73122, suggesting a G(q) protein is involved in the Bv8-induced effects.	1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione	146-152	prokineticin 2	Mus musculus	199-202
10580115-5	1999	As deduced from cloned cDNAs, the murine and human Bv8 homologues have identical amino-terminal sequences and also contain 10 cysteines.	Cysteine	126-135	prokineticin 2	Mus musculus	51-54
10580115-6	1999	From mouse testes, two forms of Bv8 mRNA have been characterized, of which one contains an additional exon which codes for 21 mostly basic amino acids.	Amino Acids, Basic	133-150	prokineticin 2	Mus musculus	32-35
34769347-6	2021	PC1 counteracted allodynia and prevented the increase of PK2 and of IL-1beta in BTZ neuropathic mice.	Bortezomib	80-83	prokineticin 2	Mus musculus	57-60
34244497-5	2021	We show that Prok2 prevents neuronal cell death by suppressing the biosynthesis of lipid peroxidation substrates, arachidonic acid-phospholipids, via accelerated F-box only protein 10 (Fbxo10)-driven ubiquitination, degradation of long-chain-fatty-acid-CoA ligase 4 (Acsl4), and inhibition of lipid peroxidation.	Arachidonic Acid	114-130	prokineticin 2	Mus musculus	13-18
34244497-5	2021	We show that Prok2 prevents neuronal cell death by suppressing the biosynthesis of lipid peroxidation substrates, arachidonic acid-phospholipids, via accelerated F-box only protein 10 (Fbxo10)-driven ubiquitination, degradation of long-chain-fatty-acid-CoA ligase 4 (Acsl4), and inhibition of lipid peroxidation.	Phospholipids	131-144	prokineticin 2	Mus musculus	13-18
31871550-0	2019	Metformin Ameliorates Testicular Damage in Male Mice with Streptozotocin-Induced Type 1 Diabetes through the PK2/PKR Pathway.	Metformin	0-9	prokineticin 2	Mus musculus	109-112
35347960-0	2022	(PK2/PKR1 signaling pathway participates in geniposide protection against diabetic nephropathy in mice).	geniposide	44-54	prokineticin 2	Mus musculus	1-4
35347960-1	2022	This study aimed to investigate the effects of geniposide(GP) on the expression of prokineticin(PK2) and prokineticin receptor 1(PKR1) in db/db mice with diabetic nephropathy(DN), so as to explore how the PK2 signaling pathway participated in the pathological changes of DN and whether GP exerted the therapeutic effect through this signaling pathway.	geniposide	47-57	prokineticin 2	Mus musculus	96-99
35347960-1	2022	This study aimed to investigate the effects of geniposide(GP) on the expression of prokineticin(PK2) and prokineticin receptor 1(PKR1) in db/db mice with diabetic nephropathy(DN), so as to explore how the PK2 signaling pathway participated in the pathological changes of DN and whether GP exerted the therapeutic effect through this signaling pathway.	geniposide	47-57	prokineticin 2	Mus musculus	205-208
33072073-3	2020	Since primary afferent sensory neurons are highly sensitive to anticancer drugs, giving rise to dysesthesias, the aim of our study was to evaluate the alterations induced by vincristine (VCR) and bortezomib (BTZ) exposure in sensory neuron cultures and the possible preventive effect of blocking PK2 signaling.	Vincristine	174-185	prokineticin 2	Mus musculus	296-299
33072073-3	2020	Since primary afferent sensory neurons are highly sensitive to anticancer drugs, giving rise to dysesthesias, the aim of our study was to evaluate the alterations induced by vincristine (VCR) and bortezomib (BTZ) exposure in sensory neuron cultures and the possible preventive effect of blocking PK2 signaling.	Bortezomib	196-206	prokineticin 2	Mus musculus	296-299
32671585-10	2020	Prokineticin 2 (Prok2) mRNA, a cytokine-like molecule associated with gastrointestinal tract inflammation, was significantly down-regulated in ethanol-fed mice.	Ethanol	143-150	prokineticin 2	Mus musculus	0-14
32671585-10	2020	Prokineticin 2 (Prok2) mRNA, a cytokine-like molecule associated with gastrointestinal tract inflammation, was significantly down-regulated in ethanol-fed mice.	Ethanol	143-150	prokineticin 2	Mus musculus	16-21
32508669-0	2020	Metformin Ameliorates Diabetic Cardiomyopathy by Activating the PK2/PKR Pathway.	Metformin	0-9	prokineticin 2	Mus musculus	64-67
32147400-4	2020	We found that the expression of Bv8 was significantly increased in two different models of retinal neovascularization: the oxygen-induced retinopathy (OIR) mouse model and the rhodopsin promoter (rho)/VEGF transgenic mouse model.	Oxygen	123-129	prokineticin 2	Mus musculus	32-35
31871550-0	2019	Metformin Ameliorates Testicular Damage in Male Mice with Streptozotocin-Induced Type 1 Diabetes through the PK2/PKR Pathway.	Streptozocin	58-72	prokineticin 2	Mus musculus	109-112
31525509-0	2019	Prokineticin 2 promotes and sustains neuroinflammation in vincristine treated mice: Focus on pain and emotional like behavior.	Vincristine	58-69	prokineticin 2	Mus musculus	0-14
29643149-0	2018	Involvement of Prokineticin 2-expressing Neutrophil Infiltration in 5-Fluorouracil-induced Aggravation of Breast Cancer Metastasis to Lung.	Fluorouracil	68-82	prokineticin 2	Mus musculus	15-29
29643149-10	2018	Collectively, 5-FU can enhance lung metastasis by inducing tumor cells to produce Cxcl1 and Cxcl2, which induced the migration of neutrophils expressing Prok2 with a capacity to enhance 4T1 cell proliferation.	Fluorouracil	14-18	prokineticin 2	Mus musculus	153-158
26914965-7	2016	Capsaicin-induced and to a lesser extent also KCl-induced CGRP releases were also augmented after Bv8 treatment.	Capsaicin	0-9	prokineticin 2	Mus musculus	98-101
26914965-7	2016	Capsaicin-induced and to a lesser extent also KCl-induced CGRP releases were also augmented after Bv8 treatment.	Potassium Chloride	46-49	prokineticin 2	Mus musculus	98-101