PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
9647223-5	1998	Decreased CD8 alpha-associated Lck activity observed with the various CD8 beta mutations also correlated with diminished in vivo cellular tyrosine phosphorylation.	Tyrosine	138-146	CD8 antigen, alpha chain	Mus musculus	10-19
9725219-4	1998	Studies to characterize and sublocalize these cis sequences showed that a 17-kb 5" subfragment is able to direct expression of the CD8 alpha gene up to the CD3intermediate DP stage but not in more mature DP or SP cells.	dp	172-174	CD8 antigen, alpha chain	Mus musculus	131-140
9399103-6	1997	Immunoblot analysis of the post-nuclear fraction of lysates from AK-T cells exposed to P815 tumor cells in the presence of anti-CD8 alpha mAb revealed reduced phosphorylation of tyrosine residues on a protein with an Mr of approximately 62 kDa.	Tyrosine	178-186	CD8 antigen, alpha chain	Mus musculus	128-137
7699318-7	1995	Thus, the differential Lck kinase activation and tyrosine phosphorylation seen with CD8 alpha alpha vs. CD8 alpha beta may reflect the unique signaling capabilities of the CD8 beta molecule.	Tyrosine	49-57	CD8 antigen, alpha chain	Mus musculus	84-93
9045916-5	1997	In contrast to B-2 cells, B-1 cells expressed Fas at only low levels in response to CD40L-CD8alpha alone or CD40L-CD8alpha + interleukin-4, and were resistant to Fas-mediated apoptosis following these treatments.	ammonium ferrous sulfate	46-49	CD8 antigen, alpha chain	Mus musculus	90-98
9087956-3	1997	Although all subsets of i-IEL including CD8 alpha/alpha(+), CD8 alpha/beta(+), CD4+ and CD4+CD8+ i-IEL were decreased after dexamethasone treatment, CD8 alpha/alpha(+) i-IEL appeared to be relatively resistant to dexamethasone-induced apoptosis.	Dexamethasone	124-137	CD8 antigen, alpha chain	Mus musculus	40-49
9087956-3	1997	Although all subsets of i-IEL including CD8 alpha/alpha(+), CD8 alpha/beta(+), CD4+ and CD4+CD8+ i-IEL were decreased after dexamethasone treatment, CD8 alpha/alpha(+) i-IEL appeared to be relatively resistant to dexamethasone-induced apoptosis.	Dexamethasone	124-137	CD8 antigen, alpha chain	Mus musculus	60-69
9087956-3	1997	Although all subsets of i-IEL including CD8 alpha/alpha(+), CD8 alpha/beta(+), CD4+ and CD4+CD8+ i-IEL were decreased after dexamethasone treatment, CD8 alpha/alpha(+) i-IEL appeared to be relatively resistant to dexamethasone-induced apoptosis.	Dexamethasone	124-137	CD8 antigen, alpha chain	Mus musculus	60-69
9087956-4	1997	Consistent with the in vivo findings, CD8 alpha/alpha(+) i-IEL exhibited less susceptibility to dexamethasone-induced cell death in vitro than other subsets.	Dexamethasone	96-109	CD8 antigen, alpha chain	Mus musculus	38-47
9594187-4	1996	The RBX implanted group had no increase of Tac but increase of Thy1 and Lyt2.	rbx	4-7	CD8 antigen, alpha chain	Mus musculus	72-76
8936043-2	1996	Lyt-2/3 antigenic activities expressed by B. regularis lymphocytes have been solubilized and purified by mAb 53-6.7 affinity chromatography and found to be associated with a single 67 kDa macromolecule in SDS-PAGE.	Sodium Dodecyl Sulfate	205-208	CD8 antigen, alpha chain	Mus musculus	0-5
23194628-5	1996	Determinations of lymphatic subsets revealed considerable upregulation (after VAA-1 treatment) and significant downregulation (after VAA-2 treatment) of immature L 3 T4(+)/Lyt-2(+) thymic cells.	vaa-2	133-138	CD8 antigen, alpha chain	Mus musculus	172-177
9045916-5	1997	In contrast to B-2 cells, B-1 cells expressed Fas at only low levels in response to CD40L-CD8alpha alone or CD40L-CD8alpha + interleukin-4, and were resistant to Fas-mediated apoptosis following these treatments.	ammonium ferrous sulfate	46-49	CD8 antigen, alpha chain	Mus musculus	114-122
9045916-6	1997	While Fas expression could be induced in B-1 cells to a comparable level as that in B-2 cells by cross-linking CD40L-CD8alpha with an anti-CD8alpha antibody, the sensitivity to Fas-mediated apoptosis in B-1 cells was significantly reduced compared with B2 cells.	ammonium ferrous sulfate	6-9	CD8 antigen, alpha chain	Mus musculus	117-125
9045916-6	1997	While Fas expression could be induced in B-1 cells to a comparable level as that in B-2 cells by cross-linking CD40L-CD8alpha with an anti-CD8alpha antibody, the sensitivity to Fas-mediated apoptosis in B-1 cells was significantly reduced compared with B2 cells.	ammonium ferrous sulfate	6-9	CD8 antigen, alpha chain	Mus musculus	139-147
9045916-6	1997	While Fas expression could be induced in B-1 cells to a comparable level as that in B-2 cells by cross-linking CD40L-CD8alpha with an anti-CD8alpha antibody, the sensitivity to Fas-mediated apoptosis in B-1 cells was significantly reduced compared with B2 cells.	ammonium ferrous sulfate	177-180	CD8 antigen, alpha chain	Mus musculus	117-125
9045916-6	1997	While Fas expression could be induced in B-1 cells to a comparable level as that in B-2 cells by cross-linking CD40L-CD8alpha with an anti-CD8alpha antibody, the sensitivity to Fas-mediated apoptosis in B-1 cells was significantly reduced compared with B2 cells.	ammonium ferrous sulfate	177-180	CD8 antigen, alpha chain	Mus musculus	139-147
7699318-7	1995	Thus, the differential Lck kinase activation and tyrosine phosphorylation seen with CD8 alpha alpha vs. CD8 alpha beta may reflect the unique signaling capabilities of the CD8 beta molecule.	Tyrosine	49-57	CD8 antigen, alpha chain	Mus musculus	104-113
8185624-4	1994	The percentages of Thy 1.2-(pan T cells), L3T4-(helper T cells) and Lyt2-(cytotoxic T cells) positive cell population were significantly increased in the mice orally administered hot water soluble fraction from wild Panax ginseng as compared to control by 31.2, 17.9 and 30.1 percent, respectively.	Water	183-188	CD8 antigen, alpha chain	Mus musculus	68-72
7825812-2	1994	This phenomenon was due to activation of antigen nonspecific L3T4-/Lyt-2- T lymphocytes (double-negative T cells) by the beta-adrenergic action of endogenous catecholamines released from the adrenal gland after pain stimulation.	Catecholamines	158-172	CD8 antigen, alpha chain	Mus musculus	67-72
8335907-7	1993	The expression of the CD8 alpha alpha homodimer in the CD4-CD8-thymocytes led to impaired intracellular calcium responses and less efficient protein tyrosine phosphorylation of substrates after TCR engagement.	Calcium	104-111	CD8 antigen, alpha chain	Mus musculus	22-31
8245775-14	1993	When both H-Y and H-2Db are expressed in the intestinal epithelium, CD8 alpha+beta+ IEL expressing the transgenic TCR are negatively selected, while the frequency of nonfunctional CD8 alpha+beta- IEL expressing the transgenic CR is increased.	Chromium	115-117	CD8 antigen, alpha chain	Mus musculus	68-77
7512525-4	1994	In contrast, secondary challenge with S. typhimurium C5 (C5) generated cell populations where both L3T4+ and Lyt-2+ T cells proliferated when cultured with formalin-killed 11RX.	Formaldehyde	156-164	CD8 antigen, alpha chain	Mus musculus	109-114
8335907-7	1993	The expression of the CD8 alpha alpha homodimer in the CD4-CD8-thymocytes led to impaired intracellular calcium responses and less efficient protein tyrosine phosphorylation of substrates after TCR engagement.	Tyrosine	149-157	CD8 antigen, alpha chain	Mus musculus	22-31
7678028-11	1993	Similar to IL-2-LAK, the IL-4-LAK subsets appeared to display a bias as to their susceptible target cells with the NK1.1-CD8 alpha+beta+ subset being most potent against trinitrophenyl-modified autologous lymphoblasts (2,4,6-trinitrobenzene sulfonic acid (TNBS)-self).	trinitrophenyl	170-184	CD8 antigen, alpha chain	Mus musculus	121-130
8359866-1	1993	CD8 (Ly-2) expression was suppressed in purified murine CD4-CD8+ thymocytes at the mRNA level upon continuous stimulation with PMA and ionomycin in the presence of rIL-2.	Tetradecanoylphorbol Acetate	127-130	CD8 antigen, alpha chain	Mus musculus	5-9
8359866-1	1993	CD8 (Ly-2) expression was suppressed in purified murine CD4-CD8+ thymocytes at the mRNA level upon continuous stimulation with PMA and ionomycin in the presence of rIL-2.	Ionomycin	135-144	CD8 antigen, alpha chain	Mus musculus	5-9
8099195-0	1993	The cysteine residues in the cytoplasmic tail of CD8 alpha are required for its coreceptor function.	Cysteine	4-12	CD8 antigen, alpha chain	Mus musculus	49-58
8099195-1	1993	The cytoplasmic segment of the CD8 alpha polypeptide includes both a cysteine-containing motif that is required for its association with the tyrosine kinase p56lck, and two serine residues which are likely to be phosphorylated and involved in inside-out signaling phenomena.	Cysteine	69-77	CD8 antigen, alpha chain	Mus musculus	31-40
8099195-1	1993	The cytoplasmic segment of the CD8 alpha polypeptide includes both a cysteine-containing motif that is required for its association with the tyrosine kinase p56lck, and two serine residues which are likely to be phosphorylated and involved in inside-out signaling phenomena.	Serine	173-179	CD8 antigen, alpha chain	Mus musculus	31-40
8099195-4	1993	In marked contrast, the CD8 alpha polypeptides bearing substitutions of both cytoplasmic cysteine residues were totally impaired in their ability to complement the co-expressed T cell receptor.	Cysteine	89-97	CD8 antigen, alpha chain	Mus musculus	24-33
8486951-4	1993	Post-sulfadiazine treatment survival was enhanced in nude mice by reconstitution with either L3T4+ or Lyt-2+ cells and was reduced in euthymic mice by monoclonal antibody treatment directed at depleting either L3T4+ or Lyt-2+ cells or interleukin-2 (IL-2) or interferon-gamma (IFN-gamma).	Sulfadiazine	5-17	CD8 antigen, alpha chain	Mus musculus	102-107
8486951-4	1993	Post-sulfadiazine treatment survival was enhanced in nude mice by reconstitution with either L3T4+ or Lyt-2+ cells and was reduced in euthymic mice by monoclonal antibody treatment directed at depleting either L3T4+ or Lyt-2+ cells or interleukin-2 (IL-2) or interferon-gamma (IFN-gamma).	Sulfadiazine	5-17	CD8 antigen, alpha chain	Mus musculus	219-224
8329838-9	1993	These results suggest that Z-100 might be able to prolong CAI observed in I10 mice through the inhibition of Lyt-2+ T suppressor cells detected in SMNC from I20 mice.	specific substance maruyama	27-32	CD8 antigen, alpha chain	Mus musculus	109-114
8505143-1	1993	The capacity of retinoids to amplify the proliferative response of BALB/c lymphocytes to concanavalin A (Con A)2 in the presence of exogenous interleukin-2 (IL-2) and the induction of IL-2 receptors (IL-2R) on L3T4+ and Lyt-2+ T-cells was evaluated.	Retinoids	16-25	CD8 antigen, alpha chain	Mus musculus	220-225
7678028-12	1993	The NK1.1+CD8 alpha-beta- effectors were most potent against YAC-1 and CL27A with little activity against TNBS-self.	cl27a	71-76	CD8 antigen, alpha chain	Mus musculus	10-19
1432998-5	1992	Monoclonal antibody to Lyt2, the murine CD8+ T cell marker, significantly reduced the levels of rheumatoid factor in pristane injected animals compared with controls, but did not influence the clinical course of PIA.	pristane	117-125	CD8 antigen, alpha chain	Mus musculus	23-27
1624219-6	1992	Significant potentiation was observed at retinoid concentrations as low as 10(-14) M. Fluorescence flow cytometry of the responding cells revealed that among L3T4+, Lyt-2+ or total T-cells, at 72 h following Con A stimulation, essentially all of the cells expressed IL-2 receptors (IL-2R).	Retinoids	41-49	CD8 antigen, alpha chain	Mus musculus	165-170
1563264-4	1992	The percentages of LYT2 cells (suppressor equivalent) were significantly lower (5.5 vs 12.0%) in mice who were treated with cimetidine vs control animals.	Cimetidine	124-134	CD8 antigen, alpha chain	Mus musculus	19-23
1498521-4	1992	Lyt-2+ cells in the spleen increased transiently (7 days) in tumor-bearing (TB) mice and returned to normal levels by 14 days TB.	Terbium	76-78	CD8 antigen, alpha chain	Mus musculus	0-5
1498521-8	1992	The numbers of Lyt-2+ cells in both the spleen and BM of 7 days indomethacin-treated TB mice were reduced relative to those of untreated TB mice.	Indomethacin	64-76	CD8 antigen, alpha chain	Mus musculus	15-20
1498521-8	1992	The numbers of Lyt-2+ cells in both the spleen and BM of 7 days indomethacin-treated TB mice were reduced relative to those of untreated TB mice.	Terbium	85-87	CD8 antigen, alpha chain	Mus musculus	15-20
1617832-6	1992	CIbT and CIT alone at the above dosage significantly reduced the number of lung colonies, retarded local tumor growth and restored NK activity of splenic killer cells expressing AGM-1+, Thy-1-, Lyt-2- phenotype.	cibt	0-4	CD8 antigen, alpha chain	Mus musculus	194-199
1617832-9	1992	CIbT or CIT alone reduced the number of spontaneous lung metastases and restored anti-YAC-1 killer function of splenocytes with NK-like phenotype (AGM-1+, Thy-1-, Lyt-2-); some anti-C3L5 killer function was also generated in the high dose Ibu group and the killer cell showed AGM-1+, Thy-1+ and Lyt-2+ phenotype.	cibt	0-4	CD8 antigen, alpha chain	Mus musculus	163-168
1617832-9	1992	CIbT or CIT alone reduced the number of spontaneous lung metastases and restored anti-YAC-1 killer function of splenocytes with NK-like phenotype (AGM-1+, Thy-1-, Lyt-2-); some anti-C3L5 killer function was also generated in the high dose Ibu group and the killer cell showed AGM-1+, Thy-1+ and Lyt-2+ phenotype.	cibt	0-4	CD8 antigen, alpha chain	Mus musculus	295-300
1319584-3	1992	Flow cytometry was used to determine whether delta 9-THC altered T cytotoxic (Lyt-2+) and T helper (L3T4+) lymphocyte numbers or cell ratios.	Dronabinol	45-56	CD8 antigen, alpha chain	Mus musculus	78-83
1319710-7	1992	Lymphoproliferative responses were abrogated in gD-immunized mice treated with anti-Thy1 or anti-L3T4, anti-Lyt2 treatment having little effect.	Gadolinium	48-50	CD8 antigen, alpha chain	Mus musculus	108-112
1602133-7	1992	New RNA synthesis was required for TGF beta-induced CD8 alpha surface expression, inasmuch as this was prevented by treatment with actinomycin D.	Dactinomycin	131-144	CD8 antigen, alpha chain	Mus musculus	52-61
1602133-9	1992	When unfractionated murine thymocytes were stimulated with phorbol dibutyrate plus ionomycin and cultured with IL-2 + TGF-beta, an increase in CD8 alpha mRNA was seen and greater numbers of CD8+ cells with higher levels of CD8 alpha and CD8 beta surface expression resulted, as compared to controls treated with IL-2 alone.	Phorbol 12,13-Dibutyrate	59-77	CD8 antigen, alpha chain	Mus musculus	143-152
1602133-9	1992	When unfractionated murine thymocytes were stimulated with phorbol dibutyrate plus ionomycin and cultured with IL-2 + TGF-beta, an increase in CD8 alpha mRNA was seen and greater numbers of CD8+ cells with higher levels of CD8 alpha and CD8 beta surface expression resulted, as compared to controls treated with IL-2 alone.	Phorbol 12,13-Dibutyrate	59-77	CD8 antigen, alpha chain	Mus musculus	223-232
1602133-9	1992	When unfractionated murine thymocytes were stimulated with phorbol dibutyrate plus ionomycin and cultured with IL-2 + TGF-beta, an increase in CD8 alpha mRNA was seen and greater numbers of CD8+ cells with higher levels of CD8 alpha and CD8 beta surface expression resulted, as compared to controls treated with IL-2 alone.	Ionomycin	83-92	CD8 antigen, alpha chain	Mus musculus	143-152
1602133-9	1992	When unfractionated murine thymocytes were stimulated with phorbol dibutyrate plus ionomycin and cultured with IL-2 + TGF-beta, an increase in CD8 alpha mRNA was seen and greater numbers of CD8+ cells with higher levels of CD8 alpha and CD8 beta surface expression resulted, as compared to controls treated with IL-2 alone.	Ionomycin	83-92	CD8 antigen, alpha chain	Mus musculus	223-232
1604489-1	1992	Treatment of murine spleen cells (SpC) with L-leucyl-L-leucine methyl ester (Leu-Leu-OMe) depletes L3T4(+) and Lyt2(+) cytotoxic T lymphocyte precursors and the capacity to generate lethal graft-versus-host disease in semiallogeneic class I + II MHC and multiple non-MHC-disparate recipient mice, whereas T helper cell function is preserved.	leucyl-leucine-methyl ester	44-75	CD8 antigen, alpha chain	Mus musculus	111-115
1604489-1	1992	Treatment of murine spleen cells (SpC) with L-leucyl-L-leucine methyl ester (Leu-Leu-OMe) depletes L3T4(+) and Lyt2(+) cytotoxic T lymphocyte precursors and the capacity to generate lethal graft-versus-host disease in semiallogeneic class I + II MHC and multiple non-MHC-disparate recipient mice, whereas T helper cell function is preserved.	leucyl-leucine-methyl ester	77-88	CD8 antigen, alpha chain	Mus musculus	111-115
1558895-3	1992	Treatment of effector cells; spleen cells from TLA-sensitized mice incubated with TLA, with anti-asialo GM1 or anti-Thy-1 plus complement inhibited the cytotoxic activity of effector cells, whereas treatment with anti-mouse Lyt-2.2 serum plus complement had no effect on the cytotoxic activity.	tert-butyl acetate	47-50	CD8 antigen, alpha chain	Mus musculus	224-229
1558895-3	1992	Treatment of effector cells; spleen cells from TLA-sensitized mice incubated with TLA, with anti-asialo GM1 or anti-Thy-1 plus complement inhibited the cytotoxic activity of effector cells, whereas treatment with anti-mouse Lyt-2.2 serum plus complement had no effect on the cytotoxic activity.	tert-butyl acetate	82-85	CD8 antigen, alpha chain	Mus musculus	224-229
1442052-1	1992	Mixed lymphocyte response was used as a main model through all the experiments In a series of concentrations (25, 50, 100, and 200 micrograms/ml), Ganoderma polysaccharides (GL-B) promoted the production of interleukin 2 (IL-2) in a concentration-dependent manner after initiation of culture for 12 h and increased the total cell recovery as well as that of Lyt 2+ and L3T4+ cells after 4 days of culture.	ganoderma polysaccharides	147-172	CD8 antigen, alpha chain	Mus musculus	358-363
1555757-4	1992	Numbers of Thy-1,2+ T lymphocytes, L3T4+ T lymphocytes, Lyt-2+ T lymphocytes and surface-immunoglobulin-positive lymphocytes decreased in spleens of the DNT-treated mice.	2,6-dinitrotoluene	153-156	CD8 antigen, alpha chain	Mus musculus	56-61
1442052-1	1992	Mixed lymphocyte response was used as a main model through all the experiments In a series of concentrations (25, 50, 100, and 200 micrograms/ml), Ganoderma polysaccharides (GL-B) promoted the production of interleukin 2 (IL-2) in a concentration-dependent manner after initiation of culture for 12 h and increased the total cell recovery as well as that of Lyt 2+ and L3T4+ cells after 4 days of culture.	gl-b	174-178	CD8 antigen, alpha chain	Mus musculus	358-363
1679379-5	1991	The DTH response to Meth A tumor was mediated by L3T4+ cells in the Meth A-immunized mice and by both L3T4+ and Lyt-2+ cells in the Meth A-bearing mice.	meth a	20-26	CD8 antigen, alpha chain	Mus musculus	112-117
2054841-6	1991	MNU administration was followed by selective differentiation of thymocytes within TNC-c to Lyt 1-thymocytes in some and to Lyt 2-thymocytes in others.	Methylnitrosourea	0-3	CD8 antigen, alpha chain	Mus musculus	123-128
1936625-5	1991	Immunohistochemical studies showed that islet-infiltrating cells in CY-treated control mice were composed mainly of both L3T4+ and Lyt-2+ T lymphocytes, whereas many L3T4+ and very few Lyt-2+ lymphocytes infiltrated within the islets in anti-Kd MoAb-injected mice.	Cyclophosphamide	68-70	CD8 antigen, alpha chain	Mus musculus	131-136
1936625-5	1991	Immunohistochemical studies showed that islet-infiltrating cells in CY-treated control mice were composed mainly of both L3T4+ and Lyt-2+ T lymphocytes, whereas many L3T4+ and very few Lyt-2+ lymphocytes infiltrated within the islets in anti-Kd MoAb-injected mice.	Cyclophosphamide	68-70	CD8 antigen, alpha chain	Mus musculus	185-190
1911547-4	1991	By mutagenesis, we show that phorbol ester-induced phosphorylation occurs exclusively on CD8 alpha serine residue 216.	Phorbol Esters	29-42	CD8 antigen, alpha chain	Mus musculus	89-98
1911547-4	1991	By mutagenesis, we show that phorbol ester-induced phosphorylation occurs exclusively on CD8 alpha serine residue 216.	Serine	99-105	CD8 antigen, alpha chain	Mus musculus	89-98
1760819-6	1991	Phenotypic analysis of splenocytes obtained from mice treated with CY on day -10 or -15 revealed a relative decrease in L3T4- and Lyt2-positive T cells.	Cyclophosphamide	67-69	CD8 antigen, alpha chain	Mus musculus	130-134
1825030-3	1991	Two signals are required for the in vitro activation of Lyt2+ T suppressor cells (Ts) from mice tolerized with 2,4-dinitrobenzene sulfonate (DNBS) to produce soluble suppressor factors (SSF) which suppress the transfer of contact sensitivity to dinitrofluorobenzene (DNFB).	2,4-dinitrobenzene sulfonate	111-139	CD8 antigen, alpha chain	Mus musculus	56-60
1825030-3	1991	Two signals are required for the in vitro activation of Lyt2+ T suppressor cells (Ts) from mice tolerized with 2,4-dinitrobenzene sulfonate (DNBS) to produce soluble suppressor factors (SSF) which suppress the transfer of contact sensitivity to dinitrofluorobenzene (DNFB).	2,4-dinitrofluorobenzene sulfonic acid	141-145	CD8 antigen, alpha chain	Mus musculus	56-60
1825030-3	1991	Two signals are required for the in vitro activation of Lyt2+ T suppressor cells (Ts) from mice tolerized with 2,4-dinitrobenzene sulfonate (DNBS) to produce soluble suppressor factors (SSF) which suppress the transfer of contact sensitivity to dinitrofluorobenzene (DNFB).	Dinitrofluorobenzene	245-265	CD8 antigen, alpha chain	Mus musculus	56-60
1825030-3	1991	Two signals are required for the in vitro activation of Lyt2+ T suppressor cells (Ts) from mice tolerized with 2,4-dinitrobenzene sulfonate (DNBS) to produce soluble suppressor factors (SSF) which suppress the transfer of contact sensitivity to dinitrofluorobenzene (DNFB).	Dinitrofluorobenzene	267-271	CD8 antigen, alpha chain	Mus musculus	56-60
1825030-16	1991	These results indicate that the Lyt2+ Ts from DNBS-tolerant mice express IL-2 receptors and IL-2 is the lymphokine which induces the Ts to release synthesized SSF.	2,4-dinitrofluorobenzene sulfonic acid	46-50	CD8 antigen, alpha chain	Mus musculus	32-36
1822437-4	1991	In comparison to antigen alone, cephalosporins (during early immune response) increased the percentage of L3T4+ cells; (3) LN cellularity was strongly enhanced by cephalosporins; (4) cefotaxime influenced the kinetics of the cellularity and the L3T4/Lyt-2 index differently than cefodizime and HBW 538.	Cephalosporins	32-46	CD8 antigen, alpha chain	Mus musculus	250-255
1822437-4	1991	In comparison to antigen alone, cephalosporins (during early immune response) increased the percentage of L3T4+ cells; (3) LN cellularity was strongly enhanced by cephalosporins; (4) cefotaxime influenced the kinetics of the cellularity and the L3T4/Lyt-2 index differently than cefodizime and HBW 538.	Cefotaxime	183-193	CD8 antigen, alpha chain	Mus musculus	250-255
2038569-6	1991	Phenotypic analysis of splenocytes used in the passive transfer assay, conducted with a biotin-avidin-immunoperoxidase technique, revealed that vitamin E treatment of mice undergoing UV irradiation prevented the UV-induced down regulation of Ia expression in splenocytes and increased the proportion of Lyt-2+ and L3T4+ splenocytes.	Vitamin E	144-153	CD8 antigen, alpha chain	Mus musculus	303-308
1826669-5	1991	Examination of the T-cell subset composition of the hydrocortisone-resistant thymocytes and peripheral lymphocytes of the challenged and unchallenged groups of experimental mice revealed large increases in the percentage of Lyt-2+ T cells, sometimes accompanied by a decrease in the L3T4+ T-cell subset compared to age-matched control BALB/c.	Hydrocortisone	52-66	CD8 antigen, alpha chain	Mus musculus	224-229
1860784-0	1991	Inhibition of lymphocyte proliferation by amantadine and its isomer, 2-aminoadamantane; impact on Lyt-2+ T cells while sparing L3T4+ T cells.	Amantadine	42-52	CD8 antigen, alpha chain	Mus musculus	98-103
1860784-0	1991	Inhibition of lymphocyte proliferation by amantadine and its isomer, 2-aminoadamantane; impact on Lyt-2+ T cells while sparing L3T4+ T cells.	2-aminoadamantane	69-86	CD8 antigen, alpha chain	Mus musculus	98-103
1860784-6	1991	The data show that the aminoadamantanes, AmTd and 2-NH2-Adam, impacted on Lyt-2+ T lymphocytes while sparing L3T4+ T lymphocytes.	Amantadine	23-39	CD8 antigen, alpha chain	Mus musculus	74-79
2007609-7	1991	However, the most significant effect of CDBA might be the maintenance of the Lyt-2+ cell level in the spleen cells from tumor-bearing mice.	beta-cyclodextrin-benzaldehyde	40-44	CD8 antigen, alpha chain	Mus musculus	77-82
1833606-6	1991	The percentage of Thy 1.2-positive splenocytes was increased by STZ and probucol reduced the percentage of Thy 1.2-positive splenocytes, although there were no differences in the populations of splenocytes, positive with Lyt 2 or L3/T4.	Probucol	72-80	CD8 antigen, alpha chain	Mus musculus	221-226
1987697-1	1991	Sensitivity of the L3T4+Lyt-2- subset to cortisone.	Cortisone	41-50	CD8 antigen, alpha chain	Mus musculus	24-29
1987697-10	1991	Following cortisone treatment the ratio of L3T4/Lyt-2 single positive thymocytes in normal F1 mice was approximately 3:1, whereas in GVH animals this ratio was reversed (1:2).	Cortisone	10-19	CD8 antigen, alpha chain	Mus musculus	48-53
1987697-13	1991	However, when these animals were treated with cortisone, the L3+T4/Lyt-2- population was more sensitive than was the L3T4- Lyt2+ population, thereby resulting in a 1:2 L3T4/Lyt-2 ratio.	Cortisone	46-55	CD8 antigen, alpha chain	Mus musculus	67-72
1987697-13	1991	However, when these animals were treated with cortisone, the L3+T4/Lyt-2- population was more sensitive than was the L3T4- Lyt2+ population, thereby resulting in a 1:2 L3T4/Lyt-2 ratio.	Cortisone	46-55	CD8 antigen, alpha chain	Mus musculus	173-178
2146233-6	1990	When C3H/HeDub mice were injected with the cytotoxic agent vinblastine sulfate, which has been shown to diminish Lyt-2+ suppressor cell activity, these mice remained unable to mount a strong local cellular response to the larval parasite.	Vinblastine	59-78	CD8 antigen, alpha chain	Mus musculus	113-118
2209764-6	1990	These results suggest that CsA and CsG can increase the cloning efficiency of normal mouse BMC, possibly by inhibiting an endogenous Lyt-2.2+ suppressor cell.	Cyclosporine	27-30	CD8 antigen, alpha chain	Mus musculus	133-138
1980087-2	1990	Increase of suppressor cel number with Lyt2.2 phenotype was found in bone marrow of C57Bl/6 mice under activation of serotoninergic system (blockade of serotonin reuptake by sertraline) as well as under blockade of dopaminergic system by administration of dopamine autoreceptor agonist--3-PPP.	Serotonin	117-126	CD8 antigen, alpha chain	Mus musculus	39-43
1980087-2	1990	Increase of suppressor cel number with Lyt2.2 phenotype was found in bone marrow of C57Bl/6 mice under activation of serotoninergic system (blockade of serotonin reuptake by sertraline) as well as under blockade of dopaminergic system by administration of dopamine autoreceptor agonist--3-PPP.	Sertraline	174-184	CD8 antigen, alpha chain	Mus musculus	39-43
1980087-2	1990	Increase of suppressor cel number with Lyt2.2 phenotype was found in bone marrow of C57Bl/6 mice under activation of serotoninergic system (blockade of serotonin reuptake by sertraline) as well as under blockade of dopaminergic system by administration of dopamine autoreceptor agonist--3-PPP.	Dopamine	215-223	CD8 antigen, alpha chain	Mus musculus	39-43
1980087-2	1990	Increase of suppressor cel number with Lyt2.2 phenotype was found in bone marrow of C57Bl/6 mice under activation of serotoninergic system (blockade of serotonin reuptake by sertraline) as well as under blockade of dopaminergic system by administration of dopamine autoreceptor agonist--3-PPP.	preclamol	285-292	CD8 antigen, alpha chain	Mus musculus	39-43
2128944-4	1990	However, when anthralin was administered for 7 days following the treatment with 400 nmol of DMBA, the suppressive effect could be transferred with Thy-1 and Lyt-2 positive spleen cells whereas the suppressive effect by the painting of anthralin only for 7 days could not be transferred with the spleen cells.	Anthralin	14-23	CD8 antigen, alpha chain	Mus musculus	158-163
2128944-4	1990	However, when anthralin was administered for 7 days following the treatment with 400 nmol of DMBA, the suppressive effect could be transferred with Thy-1 and Lyt-2 positive spleen cells whereas the suppressive effect by the painting of anthralin only for 7 days could not be transferred with the spleen cells.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	93-97	CD8 antigen, alpha chain	Mus musculus	158-163
2146233-8	1990	Effects seen following vinblastine treatment may be a result of drug-induced alterations in leukocyte chemotaxis, toxicity to other effector T cell populations, or a specific depletion of a functional Lyt-2+ T cell population that is required in addition to L3T4+ T cells for the expression of resistance to primary infection with T. taeniaeformis.	Vinblastine	23-34	CD8 antigen, alpha chain	Mus musculus	201-206
2142673-4	1990	Thus multiple cgn treatment along with priming SRBC generated non-specific and specific suppressive states which were transferable by Thy-1+ Lyt-2+ splenocytes.	srbc	47-51	CD8 antigen, alpha chain	Mus musculus	141-146
2115328-0	1990	Murine T-cell differentiation antigen CD8 is a direct substrate of protein kinase C. Murine T cell differentiation antigen CD8 alpha (Lyt-2) is phosphorylated in vivo after phorbol 12-myristate 13-acetate (PMA) treatment of cells.	Tetradecanoylphorbol Acetate	173-204	CD8 antigen, alpha chain	Mus musculus	123-132
2115328-0	1990	Murine T-cell differentiation antigen CD8 is a direct substrate of protein kinase C. Murine T cell differentiation antigen CD8 alpha (Lyt-2) is phosphorylated in vivo after phorbol 12-myristate 13-acetate (PMA) treatment of cells.	Tetradecanoylphorbol Acetate	173-204	CD8 antigen, alpha chain	Mus musculus	134-139
2115328-0	1990	Murine T-cell differentiation antigen CD8 is a direct substrate of protein kinase C. Murine T cell differentiation antigen CD8 alpha (Lyt-2) is phosphorylated in vivo after phorbol 12-myristate 13-acetate (PMA) treatment of cells.	Tetradecanoylphorbol Acetate	206-209	CD8 antigen, alpha chain	Mus musculus	123-132
2115328-0	1990	Murine T-cell differentiation antigen CD8 is a direct substrate of protein kinase C. Murine T cell differentiation antigen CD8 alpha (Lyt-2) is phosphorylated in vivo after phorbol 12-myristate 13-acetate (PMA) treatment of cells.	Tetradecanoylphorbol Acetate	206-209	CD8 antigen, alpha chain	Mus musculus	134-139
2338363-4	1990	Thus multiple cgn treatment and priming with SRBC generated non-specific and specific suppressive states which were transferable by Thy 1+ Lyt 2+ splenocytes.	srbc	45-49	CD8 antigen, alpha chain	Mus musculus	139-144
2159448-4	1990	Three weeks of daily cyclosporine and cortisone injections depleted L3T4+ cells to 6.0%, Lyt-2+ cells to 20% and anti-MCMV antibody to 10% of untreated mice.	Cyclosporine	21-33	CD8 antigen, alpha chain	Mus musculus	89-94
2159448-4	1990	Three weeks of daily cyclosporine and cortisone injections depleted L3T4+ cells to 6.0%, Lyt-2+ cells to 20% and anti-MCMV antibody to 10% of untreated mice.	Cortisone	38-47	CD8 antigen, alpha chain	Mus musculus	89-94
2302701-7	1990	Lyt-1+, Lyt-2+, and L3T4+ lymphocytes were all required for HuIL-2 to induce antitumor cytotoxic activity.	huil-2	60-66	CD8 antigen, alpha chain	Mus musculus	8-13
1689694-7	1990	FACS analyses of the spleen cells revealed that FK506 reduced the percentage of double negative T cells (Thy-1.2+, Lyt-2-, L3T4-).	Tacrolimus	48-53	CD8 antigen, alpha chain	Mus musculus	115-120
2337902-0	1990	Eradication of a large MOPC-315 tumor in athymic nude mice by chemoimmunotherapy with Lyt2+ splenic T cells from melphalan-treated BALB/c mice bearing a large MOPC-315 tumor.	Melphalan	113-122	CD8 antigen, alpha chain	Mus musculus	86-90
35288465-9	2022	BR101801 combined with irradiation systemically reduced the proliferation of regulatory T cells (Tregs) and enhanced the number of tumor-specific CD8alpha+ T cells in the tumor microenvironment, thereby leading to tumor regression.	br101801	0-8	CD8 antigen, alpha chain	Mus musculus	146-154
34321879-11	2021	Interestingly, Ng(-)pIL-12 adjuvant combined with HBsAg induced higher levels of anti-HBs IgG, IgG1 and IgG2b, promoted maturation and presentation capacity of DCs, especially CD8alpha+/CD103+ DCs.	pil-12	20-26	CD8 antigen, alpha chain	Mus musculus	176-184
1972820-7	1990	DMBA treatment had no effect on B cells or Ia expression, but decreased levels of the T lymphocyte cell surface molecule Thy-1, and increased L3T4 and Lyt-2 as quantitated by flow cytofluorimetry.	6,11-dimethylbenzo(b)naphtho(2,3-d)thiophene	0-4	CD8 antigen, alpha chain	Mus musculus	151-156
34504490-3	2021	Using the Af1521 macrodomain-based enrichment of ADP-ribosylated peptides and mass spectrometry, we identified 93 ADP-ribsoylated peptides corresponding to 67 distinct T cell proteins, including known targets such as CD8a and CD25 but also previously unknown targets such as CD73.	Peptides	65-73	CD8 antigen, alpha chain	Mus musculus	217-221
2569935-6	1989	In addition, treatment during severe thyroiditis following the transfer of MTg-activated lymph node cells showed that Lyt-2 mAb alone also reduced thyroid infiltration.	(Methylthio)acetic acid	75-78	CD8 antigen, alpha chain	Mus musculus	118-123
2788494-11	1989	Thus, Lyt 2+ T-cells independent of effector macrophages are responsible for lysis of innocent bystander tumor cells by MOPC-315-IVI spleen cells from L-PAM-cured MOPC-315 tumor bearers.	Melphalan	151-156	CD8 antigen, alpha chain	Mus musculus	6-11
2679201-5	1989	The proportions of L3T4- and Lyt-2 positive thymus cells were significantly reduced in alcohol-exposed fetuses compared to controls; however, the number of Thy-1-positive cells did not differ among any of the groups.	Alcohols	87-94	CD8 antigen, alpha chain	Mus musculus	29-34
2568174-0	1989	Importance of Lyt 2+ T-cells in the curative effectiveness of a low dose of melphalan for mice bearing a large MOPC-315 tumor.	Melphalan	76-85	CD8 antigen, alpha chain	Mus musculus	14-19
2567207-0	1989	Enhancement of the effectiveness of Lyt-2+ T-cells for adoptive chemoimmunotherapy by short-term exposure of tumor-bearer spleen cells to polyethylene glycol and/or melphalan.	Polyethylene Glycols	138-157	CD8 antigen, alpha chain	Mus musculus	36-41
2600268-5	1989	These results indicate that, following a single painting of DNFB onto Langerhans cell-deficient skin, the numbers of Lyt2+ cells do not change significantly, but do change functionally.	Dinitrofluorobenzene	60-64	CD8 antigen, alpha chain	Mus musculus	117-121
2567207-0	1989	Enhancement of the effectiveness of Lyt-2+ T-cells for adoptive chemoimmunotherapy by short-term exposure of tumor-bearer spleen cells to polyethylene glycol and/or melphalan.	Melphalan	165-174	CD8 antigen, alpha chain	Mus musculus	36-41
2785962-11	1989	Elimination of Lyt-2+ cells resulted in a 50% decrease in the response to SEs.	Selenium	74-77	CD8 antigen, alpha chain	Mus musculus	15-20
2481664-5	1989	The LHF production required Thy-1.2+, Lyt-1.1+, Lyt-2.1+ and asialo GM1- cells, and the coexistence of unstimulated accessory cells was also essential for the LHF production.	5-[[2-[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]ethylamino]methyl]-4-Azanyl-1-[2-(4-Bromanylphenoxy)ethyl]pyrimidin-2-One	4-7	CD8 antigen, alpha chain	Mus musculus	48-53
2481664-6	1989	Cells responding to both LHF and rIL 2 to generate LAK activity were Thy-1.2-, Lyt-1.1-, Lyt-2.1- and asialo GM1+.	5-[[2-[(2~{r},3~{s},4~{r},5~{r})-5-(6-Aminopurin-9-Yl)-3,4-Bis(Oxidanyl)oxolan-2-Yl]ethylamino]methyl]-4-Azanyl-1-[2-(4-Bromanylphenoxy)ethyl]pyrimidin-2-One	25-28	CD8 antigen, alpha chain	Mus musculus	89-94
2534133-9	1989	The in vivo anti-tumor activity of spleen cells of mice in regression was nullified by treatment with anti-Thy 1 and anti-Lyt 1 plus C, but not anti-Lyt 2 plus C. These results indicate that CY administration results in only a transient decrease of tumor cell number and that an induction of Lyt 1 +, Lyt 2 + T cells in the peritoneal cavity and Lyt 1 + T cells in spleen may be responsible for a complete disappearance of tumor cells.	Cyclophosphamide	191-193	CD8 antigen, alpha chain	Mus musculus	301-306
2564328-3	1989	The cells required at the time of MTg pretreatment were L3T4+, Lyt-2- and low anti-L3T4 doses had no effect on their activation.	(Methylthio)acetic acid	34-37	CD8 antigen, alpha chain	Mus musculus	63-68
2564328-4	1989	The cells that mediated the strong MTg-induced resistance following pretreatment were also L3T4+; their suppressor function could only be abrogated by depletion of L3T4+, but not Lyt-2+, cells.	(Methylthio)acetic acid	35-38	CD8 antigen, alpha chain	Mus musculus	179-184
2669797-13	1989	Old NZB.xid donor marrow reconstituted splenic Thy-1, L3T4 and Lyt2 T cells to levels less than observed with NZB donor cells.	[(5-{4-fluoro-2-[2-(pyridin-3-yl)ethoxy]phenyl}-1H-indazol-3-yl)methyl]dimethylamine	4-7	CD8 antigen, alpha chain	Mus musculus	63-67
2539396-6	1989	Once nude mice were reconstituted with nu/+ spleen cells, however, Pentostam exerted strong leishmanicidal activity, an effect that appeared to be transferred by either L3T4+ or Lyt-2+ cells.	Antimony Sodium Gluconate	67-76	CD8 antigen, alpha chain	Mus musculus	178-183
2784139-2	1989	Methotrexate selectively inhibits Lyt-2+ cells in murine acute graft-versus-host reactions.	Methotrexate	0-12	CD8 antigen, alpha chain	Mus musculus	34-39
2783708-4	1989	The time course of transcription corresponds to CTL activation, to the accumulation of Lyt-2+ and L3T4+ T cells in the spleen, to the incorporation of [3H]TdR by B cell-depleted spleen lymphocytes, and to production of IL-2 by these cells.	Tritium	152-154	CD8 antigen, alpha chain	Mus musculus	87-92
2495248-8	1989	Subsequent studies showed that the majority of IEL which respond to PMA + A23187 are L3T4+ Lyt-2-, despite the fact that Lyt-2+ cells from the spleen and thymus responded well to these agents.	Calcimycin	74-80	CD8 antigen, alpha chain	Mus musculus	91-96
2783437-4	1989	CsA abrogated the production of L3T4+ T cells and Lyt-2+ T cells in the thymus.	Cyclosporine	0-3	CD8 antigen, alpha chain	Mus musculus	50-55
2562439-4	1989	IL-2-induced proliferation, as well as that induced by concanavalin A or phorbol-ionophore mixture, was inhibited by monoclonal antibodies specific for L3T4 or Lyt-2 cell surface markers.	phorbol	73-80	CD8 antigen, alpha chain	Mus musculus	160-165
2786857-0	1989	Methyl-acetylenicputrescine (MAP), an inhibitor of polyamine biosynthesis, reduces the frequency and cytolytic activity of alloantigen-induced LyT 2.2 positive lymphocytes in vivo.	6-heptyne-2,5-diamine	0-27	CD8 antigen, alpha chain	Mus musculus	143-148
2786857-0	1989	Methyl-acetylenicputrescine (MAP), an inhibitor of polyamine biosynthesis, reduces the frequency and cytolytic activity of alloantigen-induced LyT 2.2 positive lymphocytes in vivo.	6-heptyne-2,5-diamine	29-32	CD8 antigen, alpha chain	Mus musculus	143-148
2786857-0	1989	Methyl-acetylenicputrescine (MAP), an inhibitor of polyamine biosynthesis, reduces the frequency and cytolytic activity of alloantigen-induced LyT 2.2 positive lymphocytes in vivo.	Polyamines	51-60	CD8 antigen, alpha chain	Mus musculus	143-148
2623745-1	1989	The authors recently demonstrated that cyclosporine (CsA) treatment of mice caused a remarkable reduction of L3T4+Lyt-2- subset in the thymocytes as well as the striking decrease in the size and cellularity of the thymic medulla.	Cyclosporine	39-51	CD8 antigen, alpha chain	Mus musculus	114-119
3141789-1	1988	The lymphocyte-specific tyrosine protein kinase p56lck is abundantly expressed in L3T4+ (CD4+) and Lyt-2+ (CD8+) T-lymphocytes, where it is predominantly phosphorylated in vivo on the carboxy-terminal tyrosine residue 505 (Y-505).	Tyrosine	24-32	CD8 antigen, alpha chain	Mus musculus	99-104
2784240-1	1989	Cyclosporine treatment of BALB/c mice (at a dose of 20 mg/kg every other day for 3 weeks) caused a remarkable reduction in the PNA-, L3T4+Lyt-2- subset of thymocytes.	Cyclosporine	0-12	CD8 antigen, alpha chain	Mus musculus	138-143
2784240-2	1989	A significant reduction of the L3T4+Lyt-2-subset was also observed in both the lymph node and spleen cells of CsA-treated mice, though the degree of the reduction was lower than that in thymocytes.	Cyclosporine	110-113	CD8 antigen, alpha chain	Mus musculus	36-41
2784240-3	1989	Both lymph node and spleen cells from CsA-treated mice showed a significant increase in the percentage of Thy-1.2 negative, L3T4-Lyt-2- cells (perhaps B cells).	Cyclosporine	38-41	CD8 antigen, alpha chain	Mus musculus	129-134
2784240-8	1989	These results suggest that CsA affects both thymus and spleen cells in vivo, preferentially impairing the L3T4+Lyt-2- subset (helper T cells or their precursors) within the thymus.	Cyclosporine	27-30	CD8 antigen, alpha chain	Mus musculus	111-116
3266689-3	1988	As the susceptibility of TC for CTL lysis is higher (M phi as compared to EL-4 thymoma cells), CTL are much more inactivated with the monoclonal antibodies to Lyt-2 and Lyt-3 antigens without complement.	Technetium	25-27	CD8 antigen, alpha chain	Mus musculus	159-164
3139753-1	1988	We have previously shown that Lyt-2- L3T4- T cells from the lymph nodes of MRL/lpr/lpr mice could respond to 12-O-tetradecanoylphorbol-2-acetate (TPA) and A23187 by proliferation, IL-2 secretion, and IL-2R (IL-2R) expression.	12-o-tetradecanoylphorbol-2-acetate	109-144	CD8 antigen, alpha chain	Mus musculus	30-35
3139753-1	1988	We have previously shown that Lyt-2- L3T4- T cells from the lymph nodes of MRL/lpr/lpr mice could respond to 12-O-tetradecanoylphorbol-2-acetate (TPA) and A23187 by proliferation, IL-2 secretion, and IL-2R (IL-2R) expression.	Calcimycin	155-161	CD8 antigen, alpha chain	Mus musculus	30-35
3139753-5	1988	TPA and A23187 synergistically induced both IL-2R and c-myc mRNA expression by the lpr Lyt-2- L3T4- T cells, as well as by normal T cells.	Tetradecanoylphorbol Acetate	0-3	CD8 antigen, alpha chain	Mus musculus	87-92
3139753-5	1988	TPA and A23187 synergistically induced both IL-2R and c-myc mRNA expression by the lpr Lyt-2- L3T4- T cells, as well as by normal T cells.	Calcimycin	8-14	CD8 antigen, alpha chain	Mus musculus	87-92
3139753-8	1988	The deficient expression of c-myc and its correction by cycloheximide treatment were also observed in Con A-stimulated lpr Lyt-2- L3T4- T cells.	Cycloheximide	56-69	CD8 antigen, alpha chain	Mus musculus	123-128
3139753-10	1988	These findings suggest that two separate mechanisms differentiated by their sensitivity to cycloheximide can inhibit the accumulation of mRNA for early competence genes in lpr Lyt-2- L3T4- T cells.	Cycloheximide	91-104	CD8 antigen, alpha chain	Mus musculus	176-181
2853694-8	1988	Furthermore, Lyt2+ splenic T cells also enhanced O2- production by +/+ PEM.	Superoxides	49-51	CD8 antigen, alpha chain	Mus musculus	13-17
2979010-3	1988	The level of expression of the function-associated antigens CD4 (L3T4) and CD8 (Ly-2) decreased transiently early after activation with PMA/ionomycin, but not after stimulation with Con-A.	Ionomycin	140-149	CD8 antigen, alpha chain	Mus musculus	80-84
2838358-0	1988	Administration of silica particles or anti-Lyt2 antibody prevents beta-cell destruction in NOD mice given cyclophosphamide.	Cyclophosphamide	106-122	CD8 antigen, alpha chain	Mus musculus	43-47
2838358-4	1988	After administration of cyclophosphamide, 10 of 26 untreated mice and 1 of 21 anti-Lyt2-treated mice became diabetic.	Cyclophosphamide	24-40	CD8 antigen, alpha chain	Mus musculus	83-87
3066654-9	1988	During the period of administration, CsA led to a decrease of Lyt 1 +/Lyt 2 + ratio in spleen cells and prevented the insulitis in low dose SZ-treated mice.	Cyclosporine	37-40	CD8 antigen, alpha chain	Mus musculus	70-75
3263749-4	1988	The 5-FU resistant BM progenitor is asialoGM1-, Thy.1+, Lyt.1- and Lyt.2-.	Fluorouracil	4-8	CD8 antigen, alpha chain	Mus musculus	67-72
3124954-8	1988	With chronic indomethacin therapy alone, NK-like (AGM-1+, Thy-1-,Lyt-2-) killer lymphocytes (capable of killing NK sensitive YAC-1 lymphoma and B16F10 melanoma targets) appeared in the spleen, but not lungs; no killer activity was generated in macrophages at either site.	Indomethacin	13-25	CD8 antigen, alpha chain	Mus musculus	65-70
2448375-2	1988	Injection of anti-asialo-GM1 (ASGM1) into transplanted mice strongly suppresses splenic cytotoxic activity and causes a significant reduction of spleen cells expressing ASGM1, Thy-1, and Lyt-2.	G(M1) Ganglioside	25-28	CD8 antigen, alpha chain	Mus musculus	187-192
3261121-5	1988	Lyt-2- cells which were negatively selected by monoclonal antibody and complement effected the Con A stimulated 3H-thymidine incorporation of a spleen cell culture in a different way depending on their state of differentiation.	3h-thymidine	112-124	CD8 antigen, alpha chain	Mus musculus	0-5
3261121-6	1988	While Lyt-2--cells selected from a fresh prepared spleen cell suspension increased the 3H thymidine incorporation, Lyt-2--cells selected from allogeneically stimulated cell suspension act as suppressor cells.	3h thymidine	87-99	CD8 antigen, alpha chain	Mus musculus	6-11
2908733-0	1988	Production of suppressor factors induced by ultraviolet irradiation or cis-urocanic acid requires Lyt-2+ lymphocytes.	cis-Urocanic acid	71-88	CD8 antigen, alpha chain	Mus musculus	98-103
2908733-5	1988	Similarly, Lyt-2+ cells (but not L3T4+ cells) were shown to be necessary for the production of SF by normal spleen cells cultured with cis-UCA.	cis-Urocanic acid	135-142	CD8 antigen, alpha chain	Mus musculus	11-16
3262467-2	1988	When stimulated with suboptimal concentrations of ionomycin and phorbol myristate acetate (PMA), the immature subpopulation of Lyt2-,L3T4- (2-4-) thymocytes responded to exogenous, purified IL-1 in a dose-dependent manner.	Ionomycin	50-59	CD8 antigen, alpha chain	Mus musculus	127-131
3262467-2	1988	When stimulated with suboptimal concentrations of ionomycin and phorbol myristate acetate (PMA), the immature subpopulation of Lyt2-,L3T4- (2-4-) thymocytes responded to exogenous, purified IL-1 in a dose-dependent manner.	Tetradecanoylphorbol Acetate	64-89	CD8 antigen, alpha chain	Mus musculus	127-131
3262467-2	1988	When stimulated with suboptimal concentrations of ionomycin and phorbol myristate acetate (PMA), the immature subpopulation of Lyt2-,L3T4- (2-4-) thymocytes responded to exogenous, purified IL-1 in a dose-dependent manner.	Tetradecanoylphorbol Acetate	91-94	CD8 antigen, alpha chain	Mus musculus	127-131
3261036-7	1988	The results shows that in the case or a permanently activated CTL effector cell such as Cl96, Lyt-2 is required for antigen recognition but is not essential for the triggering of cytotoxicity.	cl96	88-92	CD8 antigen, alpha chain	Mus musculus	94-99
2895062-0	1988	Lethal vaccinia infection in cyclophosphamide-suppressed mice is associated with decreased expression of Thy-1, Lyt-2 and L3T4 and diminished IL-2 production in surviving T cells.	Cyclophosphamide	29-45	CD8 antigen, alpha chain	Mus musculus	112-117
2970437-3	1988	Decreased PFC responses similarly occurred in recipient mice into which Lyt-2.1 T cells obtained from histamine-injected mice were transferred before immunization.	Histamine	102-111	CD8 antigen, alpha chain	Mus musculus	72-77
3128511-3	1988	Inclusion of anti-MH134 Lyt-2+ T cells together with MH134 tumor cells in one chamber resulted in comparable growth inhibition of viable X5563 tumor cells in the other chamber to that obtained by unfractionated MH134-hyperimmune spleen cells.	mh134	18-23	CD8 antigen, alpha chain	Mus musculus	24-29
3367653-3	1988	In contrast, 63% of the thymic lymphomas induced by the chemical carcinogen MNU, expressed an Lyt-2+ L3T4- antigenic profile.	Methylnitrosourea	76-79	CD8 antigen, alpha chain	Mus musculus	94-99
3367653-5	1988	Diagonal gel electrophoresis of 125I-labeled membrane extracts and immunoprecipitates revealed that 17 of 29 Lyt-2+ L3T4-MNU-induced lymphomas expressed cell surface T-cell receptor heterodimer components.	Iodine-125	32-36	CD8 antigen, alpha chain	Mus musculus	109-114
3367653-5	1988	Diagonal gel electrophoresis of 125I-labeled membrane extracts and immunoprecipitates revealed that 17 of 29 Lyt-2+ L3T4-MNU-induced lymphomas expressed cell surface T-cell receptor heterodimer components.	Methylnitrosourea	121-124	CD8 antigen, alpha chain	Mus musculus	109-114
3262940-3	1988	Through the use of monoclonal anti-L3T4 and anti-Lyt-2 antibodies together with two-color flow cytofluorometry, we demonstrated that CsA caused a remarkable reduction of L3T4+ Lyt-2- subset and only a slight increase in L3T4+ Lyt-2+ subset in the thymus.	Cyclosporine	133-136	CD8 antigen, alpha chain	Mus musculus	49-54
3262940-3	1988	Through the use of monoclonal anti-L3T4 and anti-Lyt-2 antibodies together with two-color flow cytofluorometry, we demonstrated that CsA caused a remarkable reduction of L3T4+ Lyt-2- subset and only a slight increase in L3T4+ Lyt-2+ subset in the thymus.	Cyclosporine	133-136	CD8 antigen, alpha chain	Mus musculus	176-181
3262940-3	1988	Through the use of monoclonal anti-L3T4 and anti-Lyt-2 antibodies together with two-color flow cytofluorometry, we demonstrated that CsA caused a remarkable reduction of L3T4+ Lyt-2- subset and only a slight increase in L3T4+ Lyt-2+ subset in the thymus.	Cyclosporine	133-136	CD8 antigen, alpha chain	Mus musculus	176-181
3262940-6	1988	The above mentioned results imply that in normal, unprimed mice CsA may preferentially impair L3T4+ Lyt-2- subset (helper T cells and their precursors) residing in the thymic medulla whereas is much less effective against L3T4+ Lyt-2+ subset present in the cortex and L3T4- Lyt-2+ subset.	Cyclosporine	64-67	CD8 antigen, alpha chain	Mus musculus	100-105
3262940-6	1988	The above mentioned results imply that in normal, unprimed mice CsA may preferentially impair L3T4+ Lyt-2- subset (helper T cells and their precursors) residing in the thymic medulla whereas is much less effective against L3T4+ Lyt-2+ subset present in the cortex and L3T4- Lyt-2+ subset.	Cyclosporine	64-67	CD8 antigen, alpha chain	Mus musculus	228-233
3262940-6	1988	The above mentioned results imply that in normal, unprimed mice CsA may preferentially impair L3T4+ Lyt-2- subset (helper T cells and their precursors) residing in the thymic medulla whereas is much less effective against L3T4+ Lyt-2+ subset present in the cortex and L3T4- Lyt-2+ subset.	Cyclosporine	64-67	CD8 antigen, alpha chain	Mus musculus	228-233
3139753-1	1988	We have previously shown that Lyt-2- L3T4- T cells from the lymph nodes of MRL/lpr/lpr mice could respond to 12-O-tetradecanoylphorbol-2-acetate (TPA) and A23187 by proliferation, IL-2 secretion, and IL-2R (IL-2R) expression.	Tetradecanoylphorbol Acetate	146-149	CD8 antigen, alpha chain	Mus musculus	30-35
3121729-1	1987	We have recently shown that interleukin 4 (IL-4) (formerly called BSF-1) is a potent stimulator of fetal and adult immature thymocyte proliferation and that adult L3T4-/Lyt-2-thymocytes can be stimulated by calcium ionophore (A23187) and phorbol ester to secrete IL-4 (Zlotnik, A., J.	Calcium	207-214	CD8 antigen, alpha chain	Mus musculus	169-174
3121729-1	1987	We have recently shown that interleukin 4 (IL-4) (formerly called BSF-1) is a potent stimulator of fetal and adult immature thymocyte proliferation and that adult L3T4-/Lyt-2-thymocytes can be stimulated by calcium ionophore (A23187) and phorbol ester to secrete IL-4 (Zlotnik, A., J.	Calcimycin	226-232	CD8 antigen, alpha chain	Mus musculus	169-174
3121729-1	1987	We have recently shown that interleukin 4 (IL-4) (formerly called BSF-1) is a potent stimulator of fetal and adult immature thymocyte proliferation and that adult L3T4-/Lyt-2-thymocytes can be stimulated by calcium ionophore (A23187) and phorbol ester to secrete IL-4 (Zlotnik, A., J.	Phorbol Esters	238-251	CD8 antigen, alpha chain	Mus musculus	169-174
3121729-15	1987	mRNA analysis of adult L3T4-/Lyt-2- thymocytes stimulated with A23187 and phorbol myristate acetate confirms that mRNA for both IL-4 and IFN-gamma is induced in adult L3T4-/Lyt-2- thymocytes.	Calcimycin	63-69	CD8 antigen, alpha chain	Mus musculus	29-34
3121729-15	1987	mRNA analysis of adult L3T4-/Lyt-2- thymocytes stimulated with A23187 and phorbol myristate acetate confirms that mRNA for both IL-4 and IFN-gamma is induced in adult L3T4-/Lyt-2- thymocytes.	Tetradecanoylphorbol Acetate	74-99	CD8 antigen, alpha chain	Mus musculus	29-34
3121729-15	1987	mRNA analysis of adult L3T4-/Lyt-2- thymocytes stimulated with A23187 and phorbol myristate acetate confirms that mRNA for both IL-4 and IFN-gamma is induced in adult L3T4-/Lyt-2- thymocytes.	Tetradecanoylphorbol Acetate	74-99	CD8 antigen, alpha chain	Mus musculus	173-178
2963718-0	1987	L3T4 and Lyt-2 T cells are both involved in the generation of low-dose streptozotocin-induced diabetes in mice.	Streptozocin	71-85	CD8 antigen, alpha chain	Mus musculus	9-14
2960741-2	1987	Immunoprecipitation and analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed that Lyt-2-L3T4-, and Lyt-2+L3T4+ thymocytes had similar T200 proteins, whereas Lyt-2+L3T4- and Lyt-2-L3T4+ thymocytes expressed a distinct set of T200 molecules.	Sodium Dodecyl Sulfate	36-58	CD8 antigen, alpha chain	Mus musculus	108-113
2960741-2	1987	Immunoprecipitation and analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed that Lyt-2-L3T4-, and Lyt-2+L3T4+ thymocytes had similar T200 proteins, whereas Lyt-2+L3T4- and Lyt-2-L3T4+ thymocytes expressed a distinct set of T200 molecules.	polyacrylamide	59-73	CD8 antigen, alpha chain	Mus musculus	108-113
2960741-2	1987	Immunoprecipitation and analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed that Lyt-2-L3T4-, and Lyt-2+L3T4+ thymocytes had similar T200 proteins, whereas Lyt-2+L3T4- and Lyt-2-L3T4+ thymocytes expressed a distinct set of T200 molecules.	polyacrylamide	59-73	CD8 antigen, alpha chain	Mus musculus	125-130
2960741-2	1987	Immunoprecipitation and analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed that Lyt-2-L3T4-, and Lyt-2+L3T4+ thymocytes had similar T200 proteins, whereas Lyt-2+L3T4- and Lyt-2-L3T4+ thymocytes expressed a distinct set of T200 molecules.	polyacrylamide	59-73	CD8 antigen, alpha chain	Mus musculus	125-130
2960741-2	1987	Immunoprecipitation and analysis by sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed that Lyt-2-L3T4-, and Lyt-2+L3T4+ thymocytes had similar T200 proteins, whereas Lyt-2+L3T4- and Lyt-2-L3T4+ thymocytes expressed a distinct set of T200 molecules.	polyacrylamide	59-73	CD8 antigen, alpha chain	Mus musculus	125-130
3500210-4	1987	This Tcs cell is a novel cell type, which can be separated from functional T suppressor (Lyt-2+) and T helper (L3T4+) cells, and the effector Tcs cell exhibits a Lyt-1+, 2-, L3T4- phenotype.	9-ethyl-N-(3,4,5-trimethoxyphenyl)carbazole-3-sulfonamide	5-8	CD8 antigen, alpha chain	Mus musculus	89-94
2445493-9	1987	Moreover, this clone is activated by F23.1, linked to Sepharose 4B beads, which was believed previously to activate only Lyt 2+, L3T4 T cells.	Sepharose	54-66	CD8 antigen, alpha chain	Mus musculus	121-126
2443601-5	1987	It was subsequently revealed that Thy-1+,Lyt-1+,Lyt-2- spleen cells from mice infected with Mo-MLV in vivo spontaneously produced surprising amounts of IL-3 in vitro, leading to the possibility that IL-3 was responsible for the generation of lines.	mo-mlv	92-98	CD8 antigen, alpha chain	Mus musculus	48-53
3668694-6	1987	The number of Lyt-2 positive cells in the spleen was lower and the ratio of L3T4 to Lyt-2 positive cells, reflecting the balance of immunoregulatory T-lymphocytes, was higher after cadmium treatment than in untreated controls.	Cadmium	181-188	CD8 antigen, alpha chain	Mus musculus	14-19
3668694-6	1987	The number of Lyt-2 positive cells in the spleen was lower and the ratio of L3T4 to Lyt-2 positive cells, reflecting the balance of immunoregulatory T-lymphocytes, was higher after cadmium treatment than in untreated controls.	Cadmium	181-188	CD8 antigen, alpha chain	Mus musculus	84-89
3498943-2	1987	It is a disulfide-bonded heterodimer in which either the alpha or alpha" polypeptide chain encoded by Ly-2 is covalently linked to the beta polypeptide chain encoded by Ly-3.	Disulfides	8-17	CD8 antigen, alpha chain	Mus musculus	102-106
3501014-6	1987	However, the spleen cells from Tx-3 mice with ovarian dysgenesis remaining after adsorption with antisera to the Lyt 2.1+Lyt 2.2 antigens (helper T cells remaining) showed increased incorporation of [3H]thymidine compared to the intact mice.	Tritium	200-202	CD8 antigen, alpha chain	Mus musculus	113-118
3501014-6	1987	However, the spleen cells from Tx-3 mice with ovarian dysgenesis remaining after adsorption with antisera to the Lyt 2.1+Lyt 2.2 antigens (helper T cells remaining) showed increased incorporation of [3H]thymidine compared to the intact mice.	Tritium	200-202	CD8 antigen, alpha chain	Mus musculus	121-126
2957697-3	1987	The gamma chains are expressed in the Lyt2-,L3T4- subsets of these T-cell populations as disulfide-linked heterodimers.	Disulfides	89-98	CD8 antigen, alpha chain	Mus musculus	38-42
2955046-7	1987	If TCR stimulation does indeed activate T cells by activating protein kinase and increasing intracellular free calcium, then our data suggest that anti-L3T4 and anti-Lyt-2 mAb inhibit TCR-driven proliferation at some step before the activation of protein kinase C and the stimulation of a rise in intracellular free calcium concentration.	Calcium	111-118	CD8 antigen, alpha chain	Mus musculus	166-171
2955046-7	1987	If TCR stimulation does indeed activate T cells by activating protein kinase and increasing intracellular free calcium, then our data suggest that anti-L3T4 and anti-Lyt-2 mAb inhibit TCR-driven proliferation at some step before the activation of protein kinase C and the stimulation of a rise in intracellular free calcium concentration.	Calcium	316-323	CD8 antigen, alpha chain	Mus musculus	166-171
2955036-2	1987	The specific tolerance induced in mice by conjugates of human monoclonal IgG (HIgG) with monomethoxypolyethylene glycol (mPEG) was transferred to normal mice by spleen cells or a surface immunoglobulin negative (sIg-) Lyt-2+ subpopulation of these cells.	monomethoxypolyethylene glycol	121-125	CD8 antigen, alpha chain	Mus musculus	218-223
3102607-3	1987	After stimulation with phorbol myristic acetate (PMA) and interleukin 2, essentially normal levels of surface antigen receptor were expressed by the lpr Lyt-2- L3T4- subpopulation but remained undetectable in the corresponding normal immature thymocyte population.	phorbol myristic acetate	23-47	CD8 antigen, alpha chain	Mus musculus	153-158
3108445-5	1987	In addition, the T lymphocytes in CSF of cyclophosphamide-suppressed, virus-infected recipients that had been injected 4 d previously with LCMV-immune spleen cells were almost entirely donor Lyt-2+ cells, while the nonlymphoid elements were exclusively of host origin.	Cyclophosphamide	41-57	CD8 antigen, alpha chain	Mus musculus	191-196
3036989-7	1987	For instance, three lines carrying the T-helper cell marker L3T4 responded only to PGE2 and not to isoproterenol, whereas two cell lines carrying the Ly2 marker gave a higher response to isoproterenol than to PGE2.	Isoproterenol	187-200	CD8 antigen, alpha chain	Mus musculus	150-153
3496413-4	1987	In vitro 5-Azacytidine induces the C4 clones to express Lyt-2 and L3T4 T cell differentiation antigens, and renders them amenable to be switched from IL-3 to IL-2 dependence.	Azacitidine	9-22	CD8 antigen, alpha chain	Mus musculus	56-61
3102607-3	1987	After stimulation with phorbol myristic acetate (PMA) and interleukin 2, essentially normal levels of surface antigen receptor were expressed by the lpr Lyt-2- L3T4- subpopulation but remained undetectable in the corresponding normal immature thymocyte population.	Tetradecanoylphorbol Acetate	49-52	CD8 antigen, alpha chain	Mus musculus	153-158
3104061-5	1987	Either accessory cells, RIF or the protein kinase C activator phorbol myristate acetate can substitute for each other and are equally active for the induction of IL 2 responsiveness in high-density Lyt-2+ T cells exposed to Con A.	Tetradecanoylphorbol Acetate	62-87	CD8 antigen, alpha chain	Mus musculus	198-203
2879870-6	1987	It was found that depletion of Thy 1- or Lyt 2-bearing precursor cells abolished the ability of spleen cells to generate LAK against TNBS-self, but had no effect on the generation of LAK against tumor cells.	Trinitrobenzenesulfonic Acid	133-137	CD8 antigen, alpha chain	Mus musculus	41-46
2879870-11	1987	The precursors generating LAK against TNBS-self were Thy-1+, Lyt-2+, AGM1+ in both fractions.	Trinitrobenzenesulfonic Acid	38-42	CD8 antigen, alpha chain	Mus musculus	61-66
2959128-2	1987	Fluorescein isothiocyanate conjugated concanavalin A (FITC-Con A) binding to negatively selected Lyt-1+ and Lyt-2+ spleen cells from nonstimulated mice and from mixed lymphocyte culture (MLC) was tested in parallel with the effect of Con A on proliferation of these cell subpopulations.	Fluorescein-5-isothiocyanate	0-26	CD8 antigen, alpha chain	Mus musculus	108-113
2959128-2	1987	Fluorescein isothiocyanate conjugated concanavalin A (FITC-Con A) binding to negatively selected Lyt-1+ and Lyt-2+ spleen cells from nonstimulated mice and from mixed lymphocyte culture (MLC) was tested in parallel with the effect of Con A on proliferation of these cell subpopulations.	fitc-con a	54-64	CD8 antigen, alpha chain	Mus musculus	108-113
2959128-3	1987	Lyt-2+ spleen cells from nonstimulated mice bound more FITC-Con A but proliferated in response to Con A to lesser extent than Lyt-1+ cells.	Fluorescein-5-isothiocyanate	55-59	CD8 antigen, alpha chain	Mus musculus	0-5
2949833-6	1987	The in vivo treatment with Cy decreased the total number of lymphoid cells in the spleens, as well as the proportion of B lymphocytes; however, it increased the percentage of both Lyt2+ and L3T4+ lymphocytes.	Cyclophosphamide	27-29	CD8 antigen, alpha chain	Mus musculus	180-184
3623773-8	1987	Spleen cell surface marker expression (Mac-1, Lyt-1, Lyt-2 and 14.8) was altered in response to cadmium or lead treatments, but these changes did not appear to correlate with the humoral immunity or mitogen-induced proliferation data.	Cadmium	96-103	CD8 antigen, alpha chain	Mus musculus	53-58
2891627-0	1987	Melphalan-induced appearance of potent antitumor immune reactivity in tumor bearer lymphocytes co-expressing the Lyt 2 and the L3T4 antigens.	Melphalan	0-9	CD8 antigen, alpha chain	Mus musculus	113-118
2891627-3	1987	This immunopotentiating activity of the Sephadex G-10-adherent spleen cells from L-PAM treated MOPC-315 tumor bearers was attributed to T-cells which co-express the Lyt 2 and the L3T4 antigens based on results of experiments employing negative selection.	sephadex	40-53	CD8 antigen, alpha chain	Mus musculus	165-170
2891627-3	1987	This immunopotentiating activity of the Sephadex G-10-adherent spleen cells from L-PAM treated MOPC-315 tumor bearers was attributed to T-cells which co-express the Lyt 2 and the L3T4 antigens based on results of experiments employing negative selection.	Melphalan	81-86	CD8 antigen, alpha chain	Mus musculus	165-170
2891627-4	1987	Specifically, depletion of Lyt 2+ cells or of L3T4+ cells abolished the ability of the Sephadex G-10-adherent splenic cell population from L-PAM treated MOPC-315 tumor bearers to bring about the generation of enhanced antitumor cytotoxicity when added to the immunization culture of normal spleen cells.	sephadex	87-100	CD8 antigen, alpha chain	Mus musculus	27-32
2891627-4	1987	Specifically, depletion of Lyt 2+ cells or of L3T4+ cells abolished the ability of the Sephadex G-10-adherent splenic cell population from L-PAM treated MOPC-315 tumor bearers to bring about the generation of enhanced antitumor cytotoxicity when added to the immunization culture of normal spleen cells.	Melphalan	139-144	CD8 antigen, alpha chain	Mus musculus	27-32
2891627-6	1987	In light of the unusual phenotype of the immunopotentiating cells in the spleens of L-PAM treated MOPC-315 tumor bearing mice (i.e. Lyt 2+ L3T4+), and since the vast majority of thymocytes in normal adult BALB/c mice co-express the Lyt 2 and the L3T4 antigens, we evaluated the effect of low dose L-PAM therapy on the antitumor immune reactivity of thymocytes from MOPC-315 tumor bearing mice.	Melphalan	84-89	CD8 antigen, alpha chain	Mus musculus	132-137
2891627-6	1987	In light of the unusual phenotype of the immunopotentiating cells in the spleens of L-PAM treated MOPC-315 tumor bearing mice (i.e. Lyt 2+ L3T4+), and since the vast majority of thymocytes in normal adult BALB/c mice co-express the Lyt 2 and the L3T4 antigens, we evaluated the effect of low dose L-PAM therapy on the antitumor immune reactivity of thymocytes from MOPC-315 tumor bearing mice.	Melphalan	84-89	CD8 antigen, alpha chain	Mus musculus	232-237
2891627-9	1987	The possibility that the Lyt 2+ L3T4+ immunopotentiating cells in the spleens of L-PAM treated MOPC-315 tumor bearers represent immature cells that have been induced by the chemotherapy to migrate from the thymus into the spleen is discussed.	Melphalan	81-86	CD8 antigen, alpha chain	Mus musculus	25-30
2946780-4	1987	The capacity to generate CTL from both L3T4 (+) and Lyt-2 (+) precursors was lost after Leu-Leu-OMe treatment, whereas alloantigen-induced proliferation and interleukin 2 (IL 2) production by L3T4 (+) T helper cells remained intact.	leucyl-leucine-methyl ester	88-99	CD8 antigen, alpha chain	Mus musculus	52-57
2946780-7	1987	However, Leu-Leu-OMe treatment of the Lyt-2 depleted inoculum completely prevented lethal GVHD, although the treated cells retained the capacity to proliferate and secrete IL 2 normally after in vitro stimulation with (C57BL/6 X DFA/2)F1 spleen cells.	leucyl-leucine-methyl ester	9-20	CD8 antigen, alpha chain	Mus musculus	38-43
2879639-3	1986	Injection of dexamethasone in increasing doses of 5-130 mg/kg body weight gradually leads to a depletion of the cortical thymocyte population, i.e., bright Thy-1 + ve, dull T-200 + ve, bright Lyt-2 + ve, and bright T4 + ve cells.	Dexamethasone	13-26	CD8 antigen, alpha chain	Mus musculus	192-197
3491147-5	1986	We previously showed that after culture with phorbol esters and interleukin 2, lpr Lyt-2- L3T4- T lymphocytes proliferate and differentiate, acquiring increased levels of surface antigen receptor by most cells, as well as Lyt-2 by a portion.	Phorbol Esters	45-59	CD8 antigen, alpha chain	Mus musculus	83-88
3491147-5	1986	We previously showed that after culture with phorbol esters and interleukin 2, lpr Lyt-2- L3T4- T lymphocytes proliferate and differentiate, acquiring increased levels of surface antigen receptor by most cells, as well as Lyt-2 by a portion.	Phorbol Esters	45-59	CD8 antigen, alpha chain	Mus musculus	222-227
2879639-13	1986	The medulla contains a subpopulation of dull Lyt-2 + ve cells, which are resistant to 20 mg/kg dexamethasone, but depleted by 130 mg/kg.	Dexamethasone	95-108	CD8 antigen, alpha chain	Mus musculus	45-50
3096745-8	1986	The Lyt-2 immunoprecipitated from one of these clones was indistinguishable from the molecule found on splenic T cells, as analyzed under reducing conditions on polyacrylamide gels, in two-dimensional charge/size separations and in peptide mapping.	polyacrylamide	161-175	CD8 antigen, alpha chain	Mus musculus	4-9
3492539-6	1987	Irradiated or mitomycin-treated small (L3T4+ or Lyt-2+) bm1-derived T cells were inefficient stimulator cells for this response.	Mitomycin	14-23	CD8 antigen, alpha chain	Mus musculus	48-53
3096745-11	1986	Lyt-2 is normally expressed on thymocytes and peripheral T cells as a heterodimer disulfide bonded to the Lyt-3 glycopeptide, yet Lyt-3 could not be detected on the cell membranes of our clones; Lyt-2 existed as stable homodimers without Lyt-3.	Disulfides	82-91	CD8 antigen, alpha chain	Mus musculus	0-5
3084634-7	1986	We have also identified a population of outer cortical MEL-14hi Lyt-2-/L3T4- lymphoblasts that appears during thymus regeneration 5 to 6 days after the administration of hydrocortisone.	Hydrocortisone	170-184	CD8 antigen, alpha chain	Mus musculus	64-69
4027979-3	1985	Here we show that the CY-induced immunopotentiating T-cells express the Lyt 1, Lyt 2, and L3T4 phenotypes.	Cyclophosphamide	22-24	CD8 antigen, alpha chain	Mus musculus	79-84
2875110-4	1986	regimen abrogated the expression of dinitrobenzene sulfonic acid-induced, Lyt-2+, T suppressor cells and stimulated contact sensitivity to dinitrofluorobenzene in adoptive transfer experiments.	dinitrobenzenesulfonic acid	36-64	CD8 antigen, alpha chain	Mus musculus	74-79
2419406-4	1986	The L3T4+, Lyt-2- dD1.9 T cell clone proliferated in response to DNP-OVA and DNBS, but not TNP-OVA or TNBS, in association with I-Ed determinants present on antigen-presenting cells.	dnp-ova	65-72	CD8 antigen, alpha chain	Mus musculus	11-16
2419406-4	1986	The L3T4+, Lyt-2- dD1.9 T cell clone proliferated in response to DNP-OVA and DNBS, but not TNP-OVA or TNBS, in association with I-Ed determinants present on antigen-presenting cells.	2,4-dinitrofluorobenzene sulfonic acid	77-81	CD8 antigen, alpha chain	Mus musculus	11-16
2874894-2	1986	T-Cell-independent B-cell tolerance to the hapten derivatives of carboxymethyl cellulose (CMC) or methyl cellulose (MC) appears to be controlled by Thy-1-, Ly-2- adherent (A) cells contained in the spleen or peritoneal fluid.	Carboxymethylcellulose Sodium	65-88	CD8 antigen, alpha chain	Mus musculus	156-160
2874894-2	1986	T-Cell-independent B-cell tolerance to the hapten derivatives of carboxymethyl cellulose (CMC) or methyl cellulose (MC) appears to be controlled by Thy-1-, Ly-2- adherent (A) cells contained in the spleen or peritoneal fluid.	Carboxymethylcellulose Sodium	90-93	CD8 antigen, alpha chain	Mus musculus	156-160
2874894-2	1986	T-Cell-independent B-cell tolerance to the hapten derivatives of carboxymethyl cellulose (CMC) or methyl cellulose (MC) appears to be controlled by Thy-1-, Ly-2- adherent (A) cells contained in the spleen or peritoneal fluid.	Methylcellulose	72-88	CD8 antigen, alpha chain	Mus musculus	156-160
2874894-2	1986	T-Cell-independent B-cell tolerance to the hapten derivatives of carboxymethyl cellulose (CMC) or methyl cellulose (MC) appears to be controlled by Thy-1-, Ly-2- adherent (A) cells contained in the spleen or peritoneal fluid.	Methylcellulose	91-93	CD8 antigen, alpha chain	Mus musculus	156-160
3484729-6	1986	Cy A-induced suppressor T cells carried both Lyt 1 and Lyt 2 surface markers.	Cyclosporine	0-4	CD8 antigen, alpha chain	Mus musculus	55-60
3877142-2	1985	Whereas Lyt-2+ cells could be induced to IL-2-dependent growth by lectin, phorbol ester, or calcium ionophore, none of these stimuli was by itself sufficient for L3T4+ cells.	Phorbol Esters	74-87	CD8 antigen, alpha chain	Mus musculus	8-13
3877142-2	1985	Whereas Lyt-2+ cells could be induced to IL-2-dependent growth by lectin, phorbol ester, or calcium ionophore, none of these stimuli was by itself sufficient for L3T4+ cells.	Calcium	92-99	CD8 antigen, alpha chain	Mus musculus	8-13
3159816-5	1985	The suppressor cells induced by higher amounts of PVP were eliminated either by injecting cyclophosphamide (CY) before priming with PVP, or by treating the primed T cells with anti-Lyt-2.2 and C before transfer.	Povidone	50-53	CD8 antigen, alpha chain	Mus musculus	181-186
3159816-6	1985	Pretreatment of suppressor T cell (Ts) donors with CY or removal of Lyt-2+ T cells not only eliminated Ts activity, but also unmasked significant Th activity in the T cells from high-dose PVP-primed mice.	Povidone	188-191	CD8 antigen, alpha chain	Mus musculus	68-73
2416810-7	1986	Lyt-2+, L3T4- T cells from the peripheral lymphoid organs of nephritic kdkd mice, after adoptive transfer into cyclophosphamide-pretreated CBA/Ca recipients, mediate an antigen-specific delayed-type hypersensitivity response to renal tubular basement membrane antigens.	Cyclophosphamide	111-127	CD8 antigen, alpha chain	Mus musculus	0-5
3872913-3	1985	TAM-mediated cytotoxicity was not dependent on the presence of TAL, as shown by T cell depletion of TAM or TAC cultures with the use of monoclonal anti-Thy-1 or anti-Lyt-2 antibody and complement.	tam	0-3	CD8 antigen, alpha chain	Mus musculus	166-171
3874157-6	1985	Their elevated concentration within this space may facilitate a low affinity binding interaction between Ly-2 and Ly-3 which is later stabilized by interchain disulfide bond formation.	Disulfides	159-168	CD8 antigen, alpha chain	Mus musculus	105-109
6238086-7	1984	Thus, SFA requires the presence of Lyt-1+ T cells, whereas EFA requires the presence of Lyt-2+ T cells.	efa	59-62	CD8 antigen, alpha chain	Mus musculus	88-93
3874829-4	1985	The administration of 1,24R-(OH)2D3 (0.1 microgram/kg/day) similarly prevented proteinuria, and produced recovery of a Lyt-2+ subset in the thymus.	1,24r-(oh)2d3	22-35	CD8 antigen, alpha chain	Mus musculus	119-124
6208146-8	1984	T cells reactive with rabbit anti-helper factor serum were found in the Lyt 2- population of cortisone-resistant thymocytes, and constituted a major subpopulation of in vitro induced helper cells, while rabbit anti-suppressor factor serum stained cells found in the Lyt 2+ population of cortisone-resistant thymocytes, as well as the majority of in vitro induced suppressor cells.	Cortisone	93-102	CD8 antigen, alpha chain	Mus musculus	72-77
6332841-2	1984	After immunization with MSCH, severe acute EAE developed in the Lyt-1- and the Lyt-1 + Lyt-2-reconstituted mice.	msch	24-28	CD8 antigen, alpha chain	Mus musculus	87-92
6205078-7	1984	By FACS analysis, TC-17 occurs independently of Lyt-1, Lyt-2, and T helper cell-specific antigens, and is more prevalent on larger proliferating thymocytes.	tc-17	18-23	CD8 antigen, alpha chain	Mus musculus	55-60
6332881-1	1984	The direct cell-mediated antitumor cytotoxicity induced by coupling a murine methylcholanthrene-induced sarcoma with N-acetylmuramyl-L-alanyl-D-isoglutamine (adjuvant peptide) was eliminated by treatment of effector cells with anti-Thy 1.2 or anti-Lyt 2.2 monoclonal antibody and complement.	Methylcholanthrene	77-95	CD8 antigen, alpha chain	Mus musculus	248-253
6332881-1	1984	The direct cell-mediated antitumor cytotoxicity induced by coupling a murine methylcholanthrene-induced sarcoma with N-acetylmuramyl-L-alanyl-D-isoglutamine (adjuvant peptide) was eliminated by treatment of effector cells with anti-Thy 1.2 or anti-Lyt 2.2 monoclonal antibody and complement.	Acetylmuramyl-Alanyl-Isoglutamine	117-156	CD8 antigen, alpha chain	Mus musculus	248-253
6234230-6	1984	Autoradiographic analysis of microenvironmental tissue positioning of [3H]-adenosine labelled cells confirmed a relatively higher localization of Lyt-2 cells in Peyer"s patches than in lymph nodes.	Tritium	71-73	CD8 antigen, alpha chain	Mus musculus	146-151
6234230-6	1984	Autoradiographic analysis of microenvironmental tissue positioning of [3H]-adenosine labelled cells confirmed a relatively higher localization of Lyt-2 cells in Peyer"s patches than in lymph nodes.	Adenosine	75-84	CD8 antigen, alpha chain	Mus musculus	146-151
6229495-6	1984	Further analysis of the T lymphocyte population was accomplished by flow cytometric analysis of in situ lymphocytes stained with fluorescein-conjugated monoclonal anti-Lyt 2 antibodies.	Fluorescein	129-140	CD8 antigen, alpha chain	Mus musculus	168-173
6610106-4	1984	The results show that the three disulfide-linked polypeptides of Lyt-2/3 molecules are all surface-expressed glycopeptides possessing hydrophobic regions residing within the lipid bilayer.	Disulfides	32-41	CD8 antigen, alpha chain	Mus musculus	65-72
6610106-4	1984	The results show that the three disulfide-linked polypeptides of Lyt-2/3 molecules are all surface-expressed glycopeptides possessing hydrophobic regions residing within the lipid bilayer.	Glycopeptides	109-122	CD8 antigen, alpha chain	Mus musculus	65-72
6610204-2	1984	The effects of eliminating cycling precursors by in vivo administration of high doses of hydroxyurea (HU) in populations of mouse spleen T lymphocytes were studied by membrane immunofluorescence identifying mature Thy 1+, Lyt 2- and Lyt 2+ cell populations and mitogen-induced T-cell growth factor (TCGF) production or reactivity to TCGF.	Hydroxyurea	89-100	CD8 antigen, alpha chain	Mus musculus	222-227
6196395-5	1983	Proliferation of IND cells [( 3H]thymidine uptake) was suppressed only if REG cells were treated with anti-Lyt-2 and C before co-culture.	Tritium	30-32	CD8 antigen, alpha chain	Mus musculus	107-112
6317754-7	1983	Lyt-2 could not be stained with any fixative, but was well preserved in frozen material post-fixed with periodate-lysine based fixatives.	metaperiodate	104-113	CD8 antigen, alpha chain	Mus musculus	0-5
6317754-7	1983	Lyt-2 could not be stained with any fixative, but was well preserved in frozen material post-fixed with periodate-lysine based fixatives.	Lysine	114-120	CD8 antigen, alpha chain	Mus musculus	0-5
6197193-8	1983	In addition, Lyt 2-depleted spleen and LN cells from sc primed BALB/c mice could restore the ability of tolerant spleen cells from 2,4,6-trinitrobenzenesulfonic acid (TNBS)-injected BALB/c mice to generate TNP-specific CTLs.	Trinitrobenzenesulfonic Acid	131-165	CD8 antigen, alpha chain	Mus musculus	13-18
6197193-8	1983	In addition, Lyt 2-depleted spleen and LN cells from sc primed BALB/c mice could restore the ability of tolerant spleen cells from 2,4,6-trinitrobenzenesulfonic acid (TNBS)-injected BALB/c mice to generate TNP-specific CTLs.	Trinitrobenzenesulfonic Acid	167-171	CD8 antigen, alpha chain	Mus musculus	13-18
6196395-5	1983	Proliferation of IND cells [( 3H]thymidine uptake) was suppressed only if REG cells were treated with anti-Lyt-2 and C before co-culture.	Thymidine	33-42	CD8 antigen, alpha chain	Mus musculus	107-112
6193189-8	1983	Monoclonal antibodies directed against the Lyt-2 antigens of CTL, but not Lyt-1 antigens, in the absence of complement inhibited the nonspecific cytotoxicity resulting from NaIO4 modification of effector lymphocytes.	metaperiodate	173-178	CD8 antigen, alpha chain	Mus musculus	43-48
6761307-3	1982	Microscopic examination of cells stained with rhodamine-labeled anti-Lyt-2 and fluorescein-labeled anti-Lyt-1 was used to measure the proportion of Lyt-1+2-, Lyt-1+2+, and Lyt-1-2+ cells in the spleen and thymus of drug-treated animals.	Rhodamines	46-55	CD8 antigen, alpha chain	Mus musculus	69-74
6241600-8	1984	It could be shown that 5-7 day bone marrow-derived DNP-labeled macrophages preferentially induced Thy 1+ Lyt 1+ antigen-specific TDH cells; 7-10 day old antigen-presenting bone marrow-derived macrophages induced preferentially Thy 1+ Lyt 2+ antigen specific Ts cells.	2,4-Dinitrophenol	51-54	CD8 antigen, alpha chain	Mus musculus	234-239
6296264-14	1983	We conclude that cytotoxic cells derived from MTg-immunized mice are Lyt-2-bearing cells but require the presence of Lyt-1-bearing cells for their generation and/or differentiation.	(Methylthio)acetic acid	46-49	CD8 antigen, alpha chain	Mus musculus	69-74
6610091-5	1983	Moreover, the anti-H-2-sensitive event was found to be reversible by the antibody as was the case with the anti-Lyt-2-sensitive event, suggesting that the two antibodies block the same event taking place during the Mg2+-dependent stage.	magnesium ion	215-219	CD8 antigen, alpha chain	Mus musculus	112-117
6191201-4	1982	Monoclonal antibody to Lyt-2 or Lyt-3 (which are linked to one another by disulfide bonds) gave a uniform distribution of fluorescence and was mobile on the cell surface.	Disulfides	74-83	CD8 antigen, alpha chain	Mus musculus	23-28
6191201-6	1982	Treatment of cells with either sodium azide or 2-mercaptoethanol followed by N-ethyl maleimide to reduce and block sulfhydryl groups inhibited the patch formation caused by simultaneous incubation with both Lyt-2 and Lyt-3 antibodies.	Sodium Azide	31-43	CD8 antigen, alpha chain	Mus musculus	207-212
6191201-6	1982	Treatment of cells with either sodium azide or 2-mercaptoethanol followed by N-ethyl maleimide to reduce and block sulfhydryl groups inhibited the patch formation caused by simultaneous incubation with both Lyt-2 and Lyt-3 antibodies.	Mercaptoethanol	47-64	CD8 antigen, alpha chain	Mus musculus	207-212
6191201-6	1982	Treatment of cells with either sodium azide or 2-mercaptoethanol followed by N-ethyl maleimide to reduce and block sulfhydryl groups inhibited the patch formation caused by simultaneous incubation with both Lyt-2 and Lyt-3 antibodies.	Ethylmaleimide	77-94	CD8 antigen, alpha chain	Mus musculus	207-212
6120202-11	1982	Using this method, IL-2 production was found to reside entirely in a subpopulation of cortisone-resistant, medium-sized Lyt-2(-) thymocytes.	Cortisone	86-95	CD8 antigen, alpha chain	Mus musculus	120-125
6761307-14	1982	The proportion of cells bearing Lyt-2 was altered by only two drugs; cyclophosphamide increased both Lyt-1+2+ and Lyt-1-2+ spleen cells and ABPP (an interferon inducer which stimulates antibody formation) decreased both Lyt-2+ subpopulations.	Cyclophosphamide	69-85	CD8 antigen, alpha chain	Mus musculus	32-37
6970223-6	1981	In addition to Thy-1, we were able to detect the T cell alloantigens Lyt-1 and Lyt-2 on nylon wool-passed spleen cells from older C57BL/6 or BALB/c nu/nu mice.	nylon wool	88-98	CD8 antigen, alpha chain	Mus musculus	79-84
6178108-4	1982	Immunoautoradiographic analysis after electrophoretic transfer of proteins from a NaDodSO4/polyacrylamide gel to a nitrocellulose membrane indicated that the Lyt-2.2 determinant detected by the monoclonal antibody resides on the Mr 28,000 component, the common subunit of both heterodimeric structures.	nadodso4	82-90	CD8 antigen, alpha chain	Mus musculus	158-163
6178108-4	1982	Immunoautoradiographic analysis after electrophoretic transfer of proteins from a NaDodSO4/polyacrylamide gel to a nitrocellulose membrane indicated that the Lyt-2.2 determinant detected by the monoclonal antibody resides on the Mr 28,000 component, the common subunit of both heterodimeric structures.	polyacrylamide	91-105	CD8 antigen, alpha chain	Mus musculus	158-163
312840-2	1979	100,000 by SDS-PAGE under reducing and nonreducing conditions was precipitated from NP-40 extracts of surface radiolabeled thymocytes from a variety of inbred strains of mice by the standard noncongenic Lyt-2.1-typing serum.	Sodium Dodecyl Sulfate	11-14	CD8 antigen, alpha chain	Mus musculus	203-208
6968778-6	1980	These results suggest that asialo GM1 is present on very early thymocytes and is lost as the mature murine T cell protein antigens Thy-1, Lyt-1, and Lyt-2 develop on these cells.	G(M1) Ganglioside	34-37	CD8 antigen, alpha chain	Mus musculus	149-154
6974198-7	1981	The partitioning of CML according to requirements for divalent cations showed that anti-Lyt-2 antibody acts on killer cells during the Mg++-dependent stage of killing.	Magnesium	135-139	CD8 antigen, alpha chain	Mus musculus	88-93
80437-5	1978	When 125I-labeled thymocytes were subjected to mild trypsinization before NP-40 extraction, the quantity of radioactive components precipitated by anti-Lyt-2.1 serum was essentially unchanged, but that of anti-Lyt-3.1-precipitable components was greatly reduced.	Iodine-125	5-9	CD8 antigen, alpha chain	Mus musculus	152-157
33424850-4	2020	In a murine model, ancestral exposure of C57BL/6 mice to low-dose DEHP led to trans-generational promoter hypomethylation of the insulin-like growth factor 2 receptor (Igf2r), concomitant with enhanced Igf2r expression and increased apoptosis prominently in CD8alpha+ DCs upon ligand stimulation, with consequent reduction in their IL-12 secretion and subsequent T cell-derived IFN-gamma, thereby promoting a default Th2-associated pulmonary allergic response.	Diethylhexyl Phthalate	66-70	CD8 antigen, alpha chain	Mus musculus	258-266
822115-4	1976	Specific precipitates obtained using anti-Ly-2.1 serum yielded SDS-PAGE profiles identical to that obtained with anti-Ly-3.1 serum, suggesting that the Ly-2 and Ly-3 antigens have the same molecular weight distribution.	Sodium Dodecyl Sulfate	63-66	CD8 antigen, alpha chain	Mus musculus	42-46
31754392-14	2019	Reduced tumor and spleen uptake of 89Zr-DFO-CD8a was observed in CD8a+ depleted mice and the uptake was comparable with that of isotype control (89Zr-DFO-IgG2b) confirming specificity.	Deferoxamine	39-43	CD8 antigen, alpha chain	Mus musculus	44-48
31648908-4	2020	Additionally, treatment of infected mice with miltefosine as experimental control exhibited host defense allowing the restoration of CD11c+CD11b+ population and decrease in CD11c+CD8alpha+ subset.	miltefosine	46-57	CD8 antigen, alpha chain	Mus musculus	179-187
32973811-1	2020	Active co-delivery of tumor antigens (Ag) and alpha-galactosylceramide (alpha-GalCer), a potent agonist for invariant Natural Killer T (iNKT) cells, to cross-priming CD8alpha+ dendritic cells (DCs) was previously shown to promote strong anti-tumor responses in mice.	alpha-galactosylceramide	46-70	CD8 antigen, alpha chain	Mus musculus	166-174
32973811-1	2020	Active co-delivery of tumor antigens (Ag) and alpha-galactosylceramide (alpha-GalCer), a potent agonist for invariant Natural Killer T (iNKT) cells, to cross-priming CD8alpha+ dendritic cells (DCs) was previously shown to promote strong anti-tumor responses in mice.	alpha-galactosylceramide	72-84	CD8 antigen, alpha chain	Mus musculus	166-174
32086762-6	2020	NOTA-CD8a was radiolabeled with Cu-64 and injected into CT26 tumor-bearing mice for longitudinal assessment.	Copper	32-34	CD8 antigen, alpha chain	Mus musculus	5-9
31887349-5	2020	Here, we showed that polyethylene glycol-phosphatidylethanolamine (PEG-PE) micelles had an extensive contact with the resident CD8alpha+ DCs in LNs and delivered more OVA peptides than their free form to these DCs.	polyethylene glycol-phosphatidylethanolamine	21-65	CD8 antigen, alpha chain	Mus musculus	127-135
31887349-5	2020	Here, we showed that polyethylene glycol-phosphatidylethanolamine (PEG-PE) micelles had an extensive contact with the resident CD8alpha+ DCs in LNs and delivered more OVA peptides than their free form to these DCs.	dioleoyl-N-(monomethoxypolyethylene glycol succinyl)phosphatidylethanolamine	67-73	CD8 antigen, alpha chain	Mus musculus	127-135
31887349-7	2020	Our findings further demonstrated the critical role of CD8alpha+ DCs in cytotoxic T cell immunity in response to PEG-PE micelle-based vaccine, and also provided a valuable approach to generate T cell-mediated immune response.	dioleoyl-N-(monomethoxypolyethylene glycol succinyl)phosphatidylethanolamine	113-119	CD8 antigen, alpha chain	Mus musculus	55-63
32360637-9	2020	Treatment with anti-CD8a antibodies lowered Tc cell numbers in all investigated tissues and induced a biochemical and histological attenuation of the HFHFD-induced NASH.	Technetium	44-46	CD8 antigen, alpha chain	Mus musculus	20-24
31754392-14	2019	Reduced tumor and spleen uptake of 89Zr-DFO-CD8a was observed in CD8a+ depleted mice and the uptake was comparable with that of isotype control (89Zr-DFO-IgG2b) confirming specificity.	Deferoxamine	39-43	CD8 antigen, alpha chain	Mus musculus	65-69
31754392-14	2019	Reduced tumor and spleen uptake of 89Zr-DFO-CD8a was observed in CD8a+ depleted mice and the uptake was comparable with that of isotype control (89Zr-DFO-IgG2b) confirming specificity.	Deferoxamine	40-43	CD8 antigen, alpha chain	Mus musculus	44-48
31754392-14	2019	Reduced tumor and spleen uptake of 89Zr-DFO-CD8a was observed in CD8a+ depleted mice and the uptake was comparable with that of isotype control (89Zr-DFO-IgG2b) confirming specificity.	Deferoxamine	40-43	CD8 antigen, alpha chain	Mus musculus	65-69
31754392-15	2019	PET imaging in syngeneic tumor models revealed a varying maximum tumor-to-heart ratio of 89Zr-DFO-CD4 and 89Zr-DFO-CD8a across tumor types and in-between subjects that correlated with individual response to Sym021 at day 10 relative to start of therapy (p=0.0002 and p=0.0354, respectively).	Deferoxamine	111-114	CD8 antigen, alpha chain	Mus musculus	115-119
31754392-17	2019	Conclusion: We developed 89Zr-DFO-CD4 and 89Zr-DFO-CD8a PET radiotracers for specific detection and whole-body assessment of CD4+ and CD8a+ status.	Deferoxamine	47-50	CD8 antigen, alpha chain	Mus musculus	51-55
31825014-5	2019	Acute exposure to nicotine-containing e-cig aerosols induced inflammatory cell influx (neutrophils and CD8a+ T-lymphocytes), and release of pro-inflammatory cytokines in bronchoalveolar lavage fluid in a sex-dependent manner.	Nicotine	18-26	CD8 antigen, alpha chain	Mus musculus	103-107
29891555-0	2018	Cysteine-Reactive Free ISG15 Generates IL-1beta-Producing CD8alpha+ Dendritic Cells at the Site of Infection.	Cysteine	0-8	CD8 antigen, alpha chain	Mus musculus	58-66
30779332-8	2019	Fasudil-modified MNCs decreased CD4+ IFN-gamma+ and CD4+ IL-17+ T cells, increased CD4+ IL-10+ T cells, restrained M1 markers CD16/32, CCR7, IL-12, CD8a, enhanced M2 markers CD206, CD200, CD14 in spleen.	fasudil	0-7	CD8 antigen, alpha chain	Mus musculus	148-152
29876477-3	2018	This data report describes the effect of retinoic acid (RA) and/or anti-interferon-gamma (IFNgamma) antibody supplementation on up-regulation of CD8alpha and Foxp3 in  Eed CD4+ T cells, the effect of dose or timing of TGFbeta treatment on CD4+ T cell identity of  Eed, adding further information regarding the conditions that induces CD8alpha, and mRNA expression changes of genes encoding polycomb repressive complex 2 (PRC2) subunits by TGFbeta treatment.	Tretinoin	41-54	CD8 antigen, alpha chain	Mus musculus	334-342
29467322-4	2018	Vancomycin treatment induced an increase in systemic CD8alpha+ DCs, which sustained systemic adoptively transferred antitumor T cells in an IL-12-dependent manner.	Vancomycin	0-10	CD8 antigen, alpha chain	Mus musculus	53-61
29358274-4	2018	Among L-EV subsets, only the CD8alpha+CD11c+ EV subset was positive for TGF-beta1 and IL-10 and could inhibit CD4+ T cell proliferation via TGF-beta1 in vitro and relieve murine asthmatic symptoms.	l-ev	6-10	CD8 antigen, alpha chain	Mus musculus	29-37
29876477-3	2018	This data report describes the effect of retinoic acid (RA) and/or anti-interferon-gamma (IFNgamma) antibody supplementation on up-regulation of CD8alpha and Foxp3 in  Eed CD4+ T cells, the effect of dose or timing of TGFbeta treatment on CD4+ T cell identity of  Eed, adding further information regarding the conditions that induces CD8alpha, and mRNA expression changes of genes encoding polycomb repressive complex 2 (PRC2) subunits by TGFbeta treatment.	Tretinoin	41-54	CD8 antigen, alpha chain	Mus musculus	145-153
29876477-3	2018	This data report describes the effect of retinoic acid (RA) and/or anti-interferon-gamma (IFNgamma) antibody supplementation on up-regulation of CD8alpha and Foxp3 in  Eed CD4+ T cells, the effect of dose or timing of TGFbeta treatment on CD4+ T cell identity of  Eed, adding further information regarding the conditions that induces CD8alpha, and mRNA expression changes of genes encoding polycomb repressive complex 2 (PRC2) subunits by TGFbeta treatment.	Tretinoin	56-58	CD8 antigen, alpha chain	Mus musculus	145-153
29876477-3	2018	This data report describes the effect of retinoic acid (RA) and/or anti-interferon-gamma (IFNgamma) antibody supplementation on up-regulation of CD8alpha and Foxp3 in  Eed CD4+ T cells, the effect of dose or timing of TGFbeta treatment on CD4+ T cell identity of  Eed, adding further information regarding the conditions that induces CD8alpha, and mRNA expression changes of genes encoding polycomb repressive complex 2 (PRC2) subunits by TGFbeta treatment.	Tretinoin	56-58	CD8 antigen, alpha chain	Mus musculus	334-342
28763795-6	2017	iMVA-induced antitumor therapy was less effective in STING- or Batf3-deficient mice than in wild-type mice, indicating that both cytosolic DNA sensing and Batf3-dependent CD103+/CD8alpha+ DCs are essential for iMVA immunotherapy.	imva	0-4	CD8 antigen, alpha chain	Mus musculus	178-186
28932640-5	2017	Our results showed for the first time that simultaneous co-delivery of the NKT agonist alpha-galactosylceramide and tumor self-antigens (Trp2 and gp100) to CD8alpha+ DCs promotes strong antitumor responses in prophylactic and therapeutic settings (advanced solid tumor model in the mouse).	alpha-galactosylceramide	87-111	CD8 antigen, alpha chain	Mus musculus	156-164
29066688-5	2017	The ratio of F4/80+ CD8a+ cells in the CY+LEM+MAK treatment group was lower than that in the untreated group.	Cysteine	39-41	CD8 antigen, alpha chain	Mus musculus	20-24
28457491-11	2017	Moreover, interferon-gamma production was greater when CD8alpha+ lymphocytes were cocultured with doxorubicin-killed neuro-2a cells and immunostimulatory cells rather than with cisplatin-killed cells.	Doxorubicin	98-109	CD8 antigen, alpha chain	Mus musculus	55-63
27548433-3	2016	MHC class I-peptide complexes were more abundant on Siglecg(-/-) CD8alpha(+) DCs than on Siglecg(+/+) CD8alpha(+) DCs.	siglecg	52-59	CD8 antigen, alpha chain	Mus musculus	65-73
27777777-13	2016	Using a library of antigen-specific CD8alpha+ T cell clones, we found that antigen-specific clones were more frequently expanded in the DPX/mCPA/anti-PD-1 treated group.	dpx	136-139	CD8 antigen, alpha chain	Mus musculus	36-44
27777777-13	2016	Using a library of antigen-specific CD8alpha+ T cell clones, we found that antigen-specific clones were more frequently expanded in the DPX/mCPA/anti-PD-1 treated group.	2-Methyl-4-chlorophenoxyacetic Acid	140-144	CD8 antigen, alpha chain	Mus musculus	36-44
24913977-0	2014	Targeted delivery of alpha-galactosylceramide to CD8alpha+ dendritic cells optimizes type I NKT cell-based antitumor responses.	alpha-galactosylceramide	21-45	CD8 antigen, alpha chain	Mus musculus	49-57
27198486-2	2016	We found that Toll-like receptor (TLR) stimuli, particularly the viral mimetic polyinosinic:polycytidylic acid (poly(I:C)), specifically induce ApoLs7/11 subfamilies in murine CD8alpha(+)  dendritic cells (DCs).	Poly C	92-110	CD8 antigen, alpha chain	Mus musculus	176-184
26137402-8	2015	Co-depletion of CD8+ T cells and NK cells did not inhibit tumor regression beyond CD8+ T-cell depletion alone, suggesting that the metronomic cyclophosphamide-activated NK cells function via CD8a+ T cells.	Cyclophosphamide	142-158	CD8 antigen, alpha chain	Mus musculus	191-195
24917008-8	2014	When CD8a + cells were co-cultured with BM-DCs and doxorubicin-treated neuro-2a cells, CD8a + lymphocyte proliferation was observed.	Doxorubicin	51-62	CD8 antigen, alpha chain	Mus musculus	5-9
24977403-0	2014	Phagocytosis of bafilomycin A1-treated apoptotic neuroblastoma cells by bone marrow-derived dendritic cells initiates a CD8alpha+ lymphocyte response to neuroblastoma.	bafilomycin A1	16-30	CD8 antigen, alpha chain	Mus musculus	120-128
24977403-7	2014	IFN-gamma secretion was maximal when Baf-A1-treated neuro-2a cells and CD8alpha lymphocytes were cocultured with BM-DCs and stimulated with CpG-ODN.	CPG-oligonucleotide	140-147	CD8 antigen, alpha chain	Mus musculus	71-79
24220301-3	2014	This subset expressed homing receptors for skin and inflammatory sites, and was mainly induced by B220(-)CD8alpha(-)CD11b(+)CD103(-) MLN-DCs in an IL-6- and OX40 ligand-dependent manner, whereas RA inhibited this induction.	Tretinoin	195-197	CD8 antigen, alpha chain	Mus musculus	105-113
24917008-8	2014	When CD8a + cells were co-cultured with BM-DCs and doxorubicin-treated neuro-2a cells, CD8a + lymphocyte proliferation was observed.	Doxorubicin	51-62	CD8 antigen, alpha chain	Mus musculus	87-91
21483862-4	2011	Crucially, resident langerin+ CD8alpha+ DCs only contributed to the priming of CD8+ T cells in the presence of maturation stimuli such as intravenous injection of TLR ligands, or by loading the BM-DCs with the glycolipid alpha-galactosylceramide (alpha-GalCer) to recruit the adjuvant activity of activated invariant natural killer-like T (iNKT) cells.	Glycolipids	210-220	CD8 antigen, alpha chain	Mus musculus	30-38
24693311-11	2014	CONCLUSIONS: In conclusion, CTP-HBcAg18-27-Tapasin could reduce apoptosis of CD8(+) T cells, increase the percentages of IFN-gamma(+) CD8alpha(+) T cells, and elicit cell-mediated immunity in HLA-A2 transgenic mice; these processes were associated with activation of the PI3K/Akt signaling pathway.	Cytidine Triphosphate	28-31	CD8 antigen, alpha chain	Mus musculus	134-142
24136200-3	2014	Upon systemic NKT cell activation through alpha-galactosylceramide stimulation however, CCL17 can be upregulated in both CD8alpha- and CD8alpha+ splenic DC subsets and enhances cross-presentation of exogenous antigens.	alpha-galactosylceramide	42-66	CD8 antigen, alpha chain	Mus musculus	121-129
24136200-3	2014	Upon systemic NKT cell activation through alpha-galactosylceramide stimulation however, CCL17 can be upregulated in both CD8alpha- and CD8alpha+ splenic DC subsets and enhances cross-presentation of exogenous antigens.	alpha-galactosylceramide	42-66	CD8 antigen, alpha chain	Mus musculus	135-143
23284054-0	2013	TLR7 triggering with polyuridylic acid promotes cross-presentation in CD8alpha+ conventional dendritic cells by enhancing antigen preservation and MHC class I antigen permanence on the dendritic cell surface.	Poly U	21-38	CD8 antigen, alpha chain	Mus musculus	70-78
24250719-8	2013	In flow cytometry analysis, AF-08 seemed to be effective in reducing the ratio of pulmonary CD8a(+) cells in RSV-infected mice with TBBPA exposure.	tetrabromobisphenol A	132-137	CD8 antigen, alpha chain	Mus musculus	92-96
22934250-2	2012	DC (BM or spleen CD8alpha(+)) have sensors for dsRNA including polyI:C to signal facilitating cross-presentation.	Poly I-C	63-70	CD8 antigen, alpha chain	Mus musculus	17-25
22472775-4	2012	The tolerogenic features of these subsets are associated with increased production of retinoic acid, which leads to the enhanced induction of Foxp3+ regulatory T cells compared with CD8alpha-beta- pDCs.	Tretinoin	86-99	CD8 antigen, alpha chain	Mus musculus	182-190
22884149-2	2012	The purpose of this study was to investigate the changes of CD8alpha(+) T cells in dextran sulfate sodium (DSS)-induced colitis mice pretreated by oral immune regulation.	Dextran Sulfate	83-105	CD8 antigen, alpha chain	Mus musculus	60-68
24548589-2	2014	Miltenyi Biotec has developed an efficient MACS protocol for isolation of CD8alpha(+) T cells from adult mice spleen.	miltenyi biotec	0-15	CD8 antigen, alpha chain	Mus musculus	74-82
24520271-8	2014	When CD8alpha+ cells were co-cultured with doxorubicin-treated neuro-2a cells and BM-DCs, CD8alpha+ cells reacted to anti-CD3/CD28 antibody stimulation, proliferated and increased IFN-gamma production.	Doxorubicin	43-54	CD8 antigen, alpha chain	Mus musculus	5-13
24520271-8	2014	When CD8alpha+ cells were co-cultured with doxorubicin-treated neuro-2a cells and BM-DCs, CD8alpha+ cells reacted to anti-CD3/CD28 antibody stimulation, proliferated and increased IFN-gamma production.	Doxorubicin	43-54	CD8 antigen, alpha chain	Mus musculus	90-98
22884149-2	2012	The purpose of this study was to investigate the changes of CD8alpha(+) T cells in dextran sulfate sodium (DSS)-induced colitis mice pretreated by oral immune regulation.	Dextran Sulfate	107-110	CD8 antigen, alpha chain	Mus musculus	60-68
22884149-8	2012	Mucosal repair in repair-period mice five days after termination of DSS treatment was also accompanied by an increase of CD8alpha(+) T cells in large intestinal mucosal lymphocytes (LI-IELs: (72.1 +- 3.7)% vs. (61.5 +- 4.5)%, P < 0.01; LI-LPLs: (62.1 +- 5.7)% vs. (52.7 +- 3.6)%, P < 0.01; n = 8).	Dextran Sulfate	68-71	CD8 antigen, alpha chain	Mus musculus	121-129
22884149-10	2012	CONCLUSION: Improvement of DSS-induced colitis resulted from oral immune regulation is associated with an increase in CD8alpha(+) T cells in spleen and large intestinal mucosa.	Dextran Sulfate	27-30	CD8 antigen, alpha chain	Mus musculus	118-126
22495988-7	2012	We found that vitamin B6 supplementation downregulates Cd8a and Ccl8 mRNA expression, suggesting these candidate genes may play a protective role against colonic ACF development.	Vitamin B 6	14-24	CD8 antigen, alpha chain	Mus musculus	55-59
21918198-0	2011	TLR agonists downregulate H2-O in CD8alpha- dendritic cells.	Water	26-30	CD8 antigen, alpha chain	Mus musculus	34-42
21918198-3	2011	In this study, we show that H2-O is markedly downregulated in vivo in mouse CD8alpha(-) DCs in response to a broad array of TLR agonists.	Water	28-32	CD8 antigen, alpha chain	Mus musculus	76-84
21918198-4	2011	In contrast, CD8alpha(+) DCs only modestly downregulated H2-O in response to TLR agonists.	Water	57-61	CD8 antigen, alpha chain	Mus musculus	13-21
21918198-6	2011	As a consequence, H2-M/H2-O ratios significantly increased for CD8alpha(-) but not for CD8alpha(+) DCs.	Hydrogen	18-20	CD8 antigen, alpha chain	Mus musculus	63-71
21918198-6	2011	As a consequence, H2-M/H2-O ratios significantly increased for CD8alpha(-) but not for CD8alpha(+) DCs.	Hydrogen	23-25	CD8 antigen, alpha chain	Mus musculus	63-71
21483862-4	2011	Crucially, resident langerin+ CD8alpha+ DCs only contributed to the priming of CD8+ T cells in the presence of maturation stimuli such as intravenous injection of TLR ligands, or by loading the BM-DCs with the glycolipid alpha-galactosylceramide (alpha-GalCer) to recruit the adjuvant activity of activated invariant natural killer-like T (iNKT) cells.	alpha-galactosylceramide	221-245	CD8 antigen, alpha chain	Mus musculus	30-38
21483862-4	2011	Crucially, resident langerin+ CD8alpha+ DCs only contributed to the priming of CD8+ T cells in the presence of maturation stimuli such as intravenous injection of TLR ligands, or by loading the BM-DCs with the glycolipid alpha-galactosylceramide (alpha-GalCer) to recruit the adjuvant activity of activated invariant natural killer-like T (iNKT) cells.	alpha-galactosylceramide	247-259	CD8 antigen, alpha chain	Mus musculus	30-38
20211938-7	2010	Moreover, TCDD selectively decreased the CD11c(high)CD8alpha(-)33D1(+) splenic DCs specialized at activating CD4(+) T cells but did not affect the regulatory CD11c(high)CD8alpha(+)DEC205(+) splenic DCs.	Polychlorinated Dibenzodioxins	10-14	CD8 antigen, alpha chain	Mus musculus	52-60
21236253-6	2011	Hypoxia-induced apoptotic and autophagic responses in vitro were examined by treating LY2 cells with CoCl(2).	cobaltous chloride	101-108	CD8 antigen, alpha chain	Mus musculus	86-89
21674051-5	2011	METHODOLOGY/PRINCIPAL FINDINGS: We report that polyinosinic:polycytidylic acid (PolyIC, synthetic analogue of dsRNA) induces dramatic apoptosis of mouse splenic conventional DC (cDC) in vivo, predominantly affecting the CD8alpha subset, as shown by flow cytometry-based analysis of splenic DC subsets.	Poly C	60-78	CD8 antigen, alpha chain	Mus musculus	220-228
21674051-5	2011	METHODOLOGY/PRINCIPAL FINDINGS: We report that polyinosinic:polycytidylic acid (PolyIC, synthetic analogue of dsRNA) induces dramatic apoptosis of mouse splenic conventional DC (cDC) in vivo, predominantly affecting the CD8alpha subset, as shown by flow cytometry-based analysis of splenic DC subsets.	Poly I-C	80-86	CD8 antigen, alpha chain	Mus musculus	220-228
18354155-5	2008	Unexpectedly, langerin(+)CD8alpha(-) dendritic cells emerged in the MLN after TCI; they did not migrate from the skin but rather differentiated rapidly from bone marrow precursors.	tci	78-81	CD8 antigen, alpha chain	Mus musculus	25-33
19950178-0	2010	An active CD8alpha/pMHCI interaction is required for CD8 single positive thymocyte differentiation.	pmhci	19-24	CD8 antigen, alpha chain	Mus musculus	10-18
19487420-0	2009	Cholera toxin inhibits IL-12 production and CD8alpha+ dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function.	Cyclic AMP	88-92	CD8 antigen, alpha chain	Mus musculus	44-52
19109193-5	2009	This CD8alpha alpha(+) population was absent in the ovary of estradiol-induced anovulatory C31F(1) mice and subfertile athymic nude mice.	Estradiol	61-70	CD8 antigen, alpha chain	Mus musculus	5-13
17610959-6	2007	Culturing CD8alpha(+) DCs with CD4(+) T cells significantly increased the proliferative response of CD4(+) T cells in the presence of CII.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	134-137	CD8 antigen, alpha chain	Mus musculus	10-18
17610959-8	2007	DBA/1 mice that were adoptively transferred with CII-pulsed CD8alpha(+) DCs and CD4(+) T cells into the footpads showed accelerated onset of CIA compared to control group.	N-[(1S)-2-methyl-1-(pyridin-4-ylcarbamoyl)propyl]cyclohexanecarboxamide	49-52	CD8 antigen, alpha chain	Mus musculus	60-68
16741956-6	2006	Despite a significantly greater spleen enlargement, flow cytometric analysis of splenocytes from the DSS-treated OPN-null mice revealed lower numbers of differentiated macrophages and (CD4+ and CD8alpha+) lymphocytes.	Dextran Sulfate	101-104	CD8 antigen, alpha chain	Mus musculus	194-202
17229401-3	2007	Treatment with RA reduced intracellular expression of IDO both in IFN-gamma-activated BMDCs in vitro and in CD11c(+)CD8alpha(+) DCs in vivo tumor-bearing mice model.	rosmarinic acid	15-17	CD8 antigen, alpha chain	Mus musculus	116-124
17056525-3	2006	In this study, we attempted to delineate the role of CD8alpha-associated Lck in driving CD8 single positive (SP) thymocyte development.	sp	109-111	CD8 antigen, alpha chain	Mus musculus	53-61
16969058-5	2006	The percentages of CD4+ and CD8 alpha + T cells in the Toxo/Dexa-treated mice were significantly reduced 2 weeks after dexamethasone treatment.	Dexamethasone	119-132	CD8 antigen, alpha chain	Mus musculus	28-37
16530222-7	2006	Analysis of the YTS 105.18 Fab epitope on CD8alpha reveals that this antibody blocks CD8 activity by hydrogen bonding to residues that are critical for interaction with both class I pMHC and TL.	Hydrogen	101-109	CD8 antigen, alpha chain	Mus musculus	42-50
16568496-2	2006	After administration of STxB chemically coupled to OVA (STxB-OVA) in mice, we showed that the immunodominant OVA(257-264) peptide restricted by K(b) molecules is specifically presented by CD11c+ CD8alpha- DC, some of them displaying a mature phenotype.	stxb	24-28	CD8 antigen, alpha chain	Mus musculus	195-203
16568496-2	2006	After administration of STxB chemically coupled to OVA (STxB-OVA) in mice, we showed that the immunodominant OVA(257-264) peptide restricted by K(b) molecules is specifically presented by CD11c+ CD8alpha- DC, some of them displaying a mature phenotype.	stxb-ova	56-64	CD8 antigen, alpha chain	Mus musculus	195-203
16517721-8	2006	CD8alpha(+) DC transfer rendered BALB/c mice susceptible to cyclosporine therapy, thereby facilitating long-term graft survival.	Cyclosporine	60-72	CD8 antigen, alpha chain	Mus musculus	0-8
19641653-7	2003	In addition, myocarditis was induced in CB3O-infected wild-type mice treated with Thy 1.2 (pan T) or Lyt 2 (CD8) antibody but not in those mice treated with L3T4 (CD4) antibody.	cb3o	40-44	CD8 antigen, alpha chain	Mus musculus	101-106
16034089-1	2005	Splenic CD8alpha+ dendritic cells reportedly tolerize T cell responses by inducing Fas ligand-mediated apoptosis, suppressing IL-2 expression, or catabolizing T cell tryptophan reserves through expression of IDO.	Tryptophan	166-176	CD8 antigen, alpha chain	Mus musculus	8-16
14597730-9	2004	Twenty-four hours after intravenous injection, chloromethylfluorescein diacetate-positive CD8alpha(+) and CD8alpha(-) mDCs were detected by immunohistochemistry in spleens in similar numbers (that decreased over time).	chloromethylfluorescein diacetate	47-80	CD8 antigen, alpha chain	Mus musculus	90-98
12471102-5	2002	Stimulation of CD11c(+)B220(+) pDCs with oligodeoxynucleotides containing certain CpG motifs plus CD40 ligand plus GM-CSF led to increased MHC class II, CD80, CD86, and CD8alpha expression levels, to a switch in chemokine receptor expression that affected their migration, to IFN-alpha and IL-12 secretion, and to the acquisition of priming capacities for both CD4(+) and CD8(+) OVA-specific TCR-transgenic naive T cells.	Oligodeoxyribonucleotides	41-62	CD8 antigen, alpha chain	Mus musculus	169-177
11120796-8	2000	The CD8alpha(+) spleen DC, apparently the most mature, displayed an extremely rapid turnover based on bromodeoxyuridine uptake and the fastest generation from bone marrow precursors.	Bromodeoxyuridine	102-119	CD8 antigen, alpha chain	Mus musculus	4-12
11986258-0	2002	CD8 alpha-deficient mice are highly susceptible to 5-fluorouracil-induced lethality.	Fluorouracil	51-65	CD8 antigen, alpha chain	Mus musculus	0-9
11986258-2	2002	We found that mice rendered deficient in CD8 alpha molecules by homologous recombination were susceptible to 5-fluorouracil (5-FU)-induced lethality accompanied by translocation of members of the enterobacteria.	Fluorouracil	109-123	CD8 antigen, alpha chain	Mus musculus	41-50
11986258-2	2002	We found that mice rendered deficient in CD8 alpha molecules by homologous recombination were susceptible to 5-fluorouracil (5-FU)-induced lethality accompanied by translocation of members of the enterobacteria.	Fluorouracil	125-129	CD8 antigen, alpha chain	Mus musculus	41-50
11986258-3	2002	The number of i-IEL was greatly reduced on day 6 after 5-FU administration in both CD8 alpha(+/-) mice and CD8 alpha(-/-) mice, whereas the recovery of the level of i-IEL thereafter was significantly impaired in CD8 alpha(-/-) mice compared with that in CD8 alpha(+/-) mice.	Fluorouracil	55-59	CD8 antigen, alpha chain	Mus musculus	83-92
11986258-3	2002	The number of i-IEL was greatly reduced on day 6 after 5-FU administration in both CD8 alpha(+/-) mice and CD8 alpha(-/-) mice, whereas the recovery of the level of i-IEL thereafter was significantly impaired in CD8 alpha(-/-) mice compared with that in CD8 alpha(+/-) mice.	Fluorouracil	55-59	CD8 antigen, alpha chain	Mus musculus	107-116
11986258-3	2002	The number of i-IEL was greatly reduced on day 6 after 5-FU administration in both CD8 alpha(+/-) mice and CD8 alpha(-/-) mice, whereas the recovery of the level of i-IEL thereafter was significantly impaired in CD8 alpha(-/-) mice compared with that in CD8 alpha(+/-) mice.	Fluorouracil	55-59	CD8 antigen, alpha chain	Mus musculus	107-116
11986258-3	2002	The number of i-IEL was greatly reduced on day 6 after 5-FU administration in both CD8 alpha(+/-) mice and CD8 alpha(-/-) mice, whereas the recovery of the level of i-IEL thereafter was significantly impaired in CD8 alpha(-/-) mice compared with that in CD8 alpha(+/-) mice.	Fluorouracil	55-59	CD8 antigen, alpha chain	Mus musculus	107-116
11986258-5	2002	Transfer of CD8(+) i-IEL conferred significant protection against 5-FU-induced lethality in CD8 alpha(-/-) mice.	Fluorouracil	66-70	CD8 antigen, alpha chain	Mus musculus	92-101
10623829-1	2000	The T cell coreceptor CD8 exists on mature T cells as disulfide-linked homodimers of CD8 alpha polypeptide chains and heterodimers of CD8 alpha- and CD8 beta-chains.	Disulfides	54-63	CD8 antigen, alpha chain	Mus musculus	85-94
10657625-4	2000	Similarly, OX8 Ab (CD8 alpha) stimulated NR8383 cells to secrete TNF, IL-1 beta, and NO.	ox8 ab	11-17	CD8 antigen, alpha chain	Mus musculus	19-28
10623829-10	2000	Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed.	Cysteine	28-36	CD8 antigen, alpha chain	Mus musculus	49-58
10352271-9	1999	Endotoxin enhancement of C4H3 staining is seen for both CD8alpha- and CD8alpha+ DC subsets.	c4h3	25-29	CD8 antigen, alpha chain	Mus musculus	56-64
10352271-9	1999	Endotoxin enhancement of C4H3 staining is seen for both CD8alpha- and CD8alpha+ DC subsets.	c4h3	25-29	CD8 antigen, alpha chain	Mus musculus	70-78