PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 21173150-4 2011 SLC1-1 allows the incorporation of C26:0 fatty acids into phosphatidylinositol (PI), thus generating PI"", an abnormal, C26-containing PI, presumably acting as surrogate for inositolphosphorylceramide. Fatty Acids 41-52 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 0-4 21173150-4 2011 SLC1-1 allows the incorporation of C26:0 fatty acids into phosphatidylinositol (PI), thus generating PI"", an abnormal, C26-containing PI, presumably acting as surrogate for inositolphosphorylceramide. Phosphatidylinositols 58-78 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 0-4 21173150-4 2011 SLC1-1 allows the incorporation of C26:0 fatty acids into phosphatidylinositol (PI), thus generating PI"", an abnormal, C26-containing PI, presumably acting as surrogate for inositolphosphorylceramide. inositolphosphorylceramide 174-200 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 0-4 21173150-10 2011 Synthesis of inositolphosphorylceramides and inositolphosphorylphytosphingosines is operated by Aur1p and is essential for growth of all 4Delta cells unless they contain SLC1-1. inositolphosphorylceramide 13-40 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 170-174 21173150-12 2011 Furthermore, mannosylation of PI"" is required for the survival of sphingolipid-deficient strains, which depend on SLC1-1. Sphingolipids 67-79 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 115-121 20694142-9 2010 CONCLUSIONS: We found that Slc1p utilized fatty acid (FA) 18:1 and FA 14:0 as substrates to synthesize corresponding PAs; moreover, it was probably the only acyltransferase responsible for acylation of saturated short-chain fatty acyls (12:0 and 10:0) in S. cerevisiae. Fatty Acids 42-52 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 27-32 20694142-9 2010 CONCLUSIONS: We found that Slc1p utilized fatty acid (FA) 18:1 and FA 14:0 as substrates to synthesize corresponding PAs; moreover, it was probably the only acyltransferase responsible for acylation of saturated short-chain fatty acyls (12:0 and 10:0) in S. cerevisiae. Protactinium 117-120 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 27-32 20694142-9 2010 CONCLUSIONS: We found that Slc1p utilized fatty acid (FA) 18:1 and FA 14:0 as substrates to synthesize corresponding PAs; moreover, it was probably the only acyltransferase responsible for acylation of saturated short-chain fatty acyls (12:0 and 10:0) in S. cerevisiae. saturated short-chain fatty acyls 202-235 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 27-32 18154737-5 2008 Finally, we show that ScLPLAT differs from the specific lysophosphatidic acid acyltransferase that is encoded by SLC1 in that it cannot efficiently use lysophosphatidic acid produced by acylation of glycerol-3-phosphate in vitro. lysophosphatidic acid 56-77 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 113-117 20176132-9 2010 Defects in the remodeling of diC10PE in the deletion mutants of ALE1 and SLC1, products of which were capable of acyl-transfer to the sn-2 position of lyso-phospholipids, suggested their involvement in the introduction of acyl residues to the sn-2 position of lyso-phosphatidylethanolamine in the remodeling reaction of diC10PE. Lysophospholipids 151-169 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 73-77 20176132-9 2010 Defects in the remodeling of diC10PE in the deletion mutants of ALE1 and SLC1, products of which were capable of acyl-transfer to the sn-2 position of lyso-phospholipids, suggested their involvement in the introduction of acyl residues to the sn-2 position of lyso-phosphatidylethanolamine in the remodeling reaction of diC10PE. lysophosphatidylethanolamine 260-289 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 73-77 19768478-0 2009 Changes in oil content of transgenic soybeans expressing the yeast SLC1 gene. Oils 11-14 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 67-71 19768478-1 2009 The wild type (Wt) and mutant form of yeast (sphingolipid compensation) genes, SLC1 and SLC1-1, have been shown to have lysophosphatidic acid acyltransferase (LPAT) activities (Nageic et al. Sphingolipids 45-57 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 79-83 19768478-1 2009 The wild type (Wt) and mutant form of yeast (sphingolipid compensation) genes, SLC1 and SLC1-1, have been shown to have lysophosphatidic acid acyltransferase (LPAT) activities (Nageic et al. Sphingolipids 45-57 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 88-94 18154737-5 2008 Finally, we show that ScLPLAT differs from the specific lysophosphatidic acid acyltransferase that is encoded by SLC1 in that it cannot efficiently use lysophosphatidic acid produced by acylation of glycerol-3-phosphate in vitro. alpha-glycerophosphoric acid 199-219 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 113-117 17726007-12 2007 Therefore, Lpt1p, a member of the membrane-bound o-acyltransferase gene family, seems to work in conjunction with Slc1 to mediate the incorporation of unsaturated acyl chains into the sn-2 position of phospholipids. Phospholipids 201-214 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 114-118 17890783-3 2007 In Saccharomyces cerevisiae, SLC1 has been identified as the gene encoding lysophosphatidic acid acyltransferase, which catalyzes PA synthesis. Phosphatidic Acids 130-132 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 29-33 17890783-14 2007 These results indicate that, in concert with Slc1, Lpt1 plays a central role in PA biosynthesis, which is essential for cell viability. Phosphatidic Acids 80-82 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 45-49 17675291-2 2007 In yeast, it is generated from lysophosphatidic acid, which is acylated by Slc1p, an sn-2-specific, acyl-coenzyme A-dependent 1-acylglycerol-3-phosphate O-acyltransferase. lysophosphatidic acid 31-52 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 75-80 17675291-7 2007 Mass spectrometric analysis of lipids from slc1Delta and slc4Delta cells demonstrates that in vivo Slc1p and Slc4p generate almost the same glycerophospholipid profile. Glycerophospholipids 140-159 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 99-104 10049376-1 1999 In the yeast Saccharomyces cerevisiae lipid particles harbor two acyltransferases, Gat1p and Slc1p, which catalyze subsequent steps of acylation required for the formation of phosphatidic acid. Phosphatidic Acids 175-192 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 93-98 17675291-9 2007 However, the lipid profiles generated by microsomes from slc1Delta and slc4Delta cells are different, and this suggests that Slc1p and Slc4p have a different substrate specificity or have access to different lyso-glycerophospholipid substrates because of a different subcellular location. lyso-glycerophospholipid 208-232 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 125-130 17675291-10 2007 Indeed, affinity-purified Slc1p displays Mg2+-dependent acyltransferase activity not only toward lysophosphatidic acid but also lyso forms of phosphatidylserine and phosphatidylinositol. lysophosphatidic acid 97-118 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 26-31 17675291-10 2007 Indeed, affinity-purified Slc1p displays Mg2+-dependent acyltransferase activity not only toward lysophosphatidic acid but also lyso forms of phosphatidylserine and phosphatidylinositol. Phosphatidylinositols 165-185 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 26-31 17675291-11 2007 Thus, Slc1p and Slc4p may not only be active as 1-acylglycerol-3-phosphate O-acyltransferases but also be involved in fatty acid exchange at the sn-2-position of mature glycerophospholipids. Fatty Acids 118-128 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 6-11 17675291-11 2007 Thus, Slc1p and Slc4p may not only be active as 1-acylglycerol-3-phosphate O-acyltransferases but also be involved in fatty acid exchange at the sn-2-position of mature glycerophospholipids. Glycerophospholipids 169-189 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 6-11 11171262-0 2000 Utility of the Arabidopsis FAE1 and yeast SLC1-1 genes for improvements in erucic acid and oil content in rapeseed. erucic acid 75-86 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 42-46 11171262-0 2000 Utility of the Arabidopsis FAE1 and yeast SLC1-1 genes for improvements in erucic acid and oil content in rapeseed. Oils 91-94 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 42-46 10049376-9 1999 In the gat1 mutant and the 1-acylglycerol-3-phosphate acyltransferase slc1 mutant, the dihydroxyacetone phosphate pathway of phosphatidic acid biosynthesis is slightly preferred as compared to the wild type. Dihydroxyacetone Phosphate 87-113 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 70-74 10049376-9 1999 In the gat1 mutant and the 1-acylglycerol-3-phosphate acyltransferase slc1 mutant, the dihydroxyacetone phosphate pathway of phosphatidic acid biosynthesis is slightly preferred as compared to the wild type. Phosphatidic Acids 125-142 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 70-74 10049376-10 1999 Thus, mutations of the major acyltransferases Gat1p and Slc1p lead to an increased contribution of mitochondrial acyltransferase(s) to glycerolipid synthesis due to their substrate preference for dihydroxyacetone phosphate. glycerolipid 135-147 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 56-61 10049376-10 1999 Thus, mutations of the major acyltransferases Gat1p and Slc1p lead to an increased contribution of mitochondrial acyltransferase(s) to glycerolipid synthesis due to their substrate preference for dihydroxyacetone phosphate. Dihydroxyacetone Phosphate 196-222 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 56-61 9212466-1 1997 A putative yeast sn-2 acyltransferase gene (SLC1-1), reportedly a variant acyltransferase that suppresses a genetic defect in sphingolipid long-chain base biosynthesis, has been expressed in a yeast SLC deletion strain. Sphingolipids 126-138 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 44-50 9212466-2 1997 The SLC1-1 gene product was shown in vitro to encode an sn-2 acyltransferase capable of acylating sn-1 oleoyl-lysophosphatidic acid, using a range of acyl-CoA thioesters, including 18:1-, 22:1-, and 24:0-CoAs. sn-1 oleoyl-lysophosphatidic acid 98-131 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 4-10 9212466-2 1997 The SLC1-1 gene product was shown in vitro to encode an sn-2 acyltransferase capable of acylating sn-1 oleoyl-lysophosphatidic acid, using a range of acyl-CoA thioesters, including 18:1-, 22:1-, and 24:0-CoAs. acyl-coa thioesters 150-169 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 4-10 9212466-3 1997 The SLC1-1 gene was introduced into Arabidopsis and a high erucic acid-containing Brassica napus cv Hero under the control of a constitutive (tandem cauliflower mosaic virus 35S) promoter. erucic acid 59-70 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 4-10 8628245-6 1996 Tetrad analysis of heterozygotes harboring a TRP insertion in the SLC1 coding region indicate that SLC1 function is not essential for cell viability. Tryptophan 45-48 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 66-70 33180170-5 2020 Then, tolerance engineering was applied by overexpression of a stress-inducible gene SLC1 in the metabolically engineered strain to further enhance 2-PE production. Phenylethyl Alcohol 148-152 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 85-89 27920551-8 2016 Therefore, Gat2p and Slc1p dictate phospholipid acyl chain composition in rich media at 30 C. Slc1p selectively pairs acyl chains of different lengths. Phospholipids 35-47 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 21-26 27920551-8 2016 Therefore, Gat2p and Slc1p dictate phospholipid acyl chain composition in rich media at 30 C. Slc1p selectively pairs acyl chains of different lengths. Phospholipids 35-47 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 94-99 26643989-5 2016 Slc1 readily acylated lysoPtdOH, lysoPtdCho and lysoPtdEtn but showed no reversibility towards PtdCho, very little reversibility towards PtdEtn and very high reversibility towards PtdOH. lysoptdoh 22-31 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 0-4 26643989-5 2016 Slc1 readily acylated lysoPtdOH, lysoPtdCho and lysoPtdEtn but showed no reversibility towards PtdCho, very little reversibility towards PtdEtn and very high reversibility towards PtdOH. lysoptdetn 48-58 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 0-4 23268448-8 2013 Via TEAK we identified a nonlinear glycerophospholipid metabolism subpathway involving the SLC1 gene, which we found via mutational analysis to be required for yeast filamentous growth. Glycerophospholipids 35-54 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 91-95 21849510-1 2011 In yeast, phosphatidic acid, the biosynthetic precursor for all glycerophospholipids and triacylglycerols, is made de novo by the 1-acyl-sn-glycerol-3-phosphate acyltransferases Ale1p and Slc1p. Phosphatidic Acids 10-27 1-acylglycerol-3-phosphate O-acyltransferase SLC1 Saccharomyces cerevisiae S288C 188-193