PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
21383145-0	2011	Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways.	N2,N4-dibenzylquinazoline-2,4-diamine	29-33	melanotransferrin	Homo sapiens	24-27
21343295-5	2011	This screen identified Syk inhibitor III as an irreversible p97/vasolin containing protein inhibitor (IC(50) = 1.7 muM) that acts through Cys-522 within the D2 ATPase domain.	Cysteine	138-141	melanotransferrin	Homo sapiens	60-63
21383145-4	2011	N2,N4-dibenzylquinazoline-2,4-diamine (DBeQ) was identified as a selective, potent, reversible, and ATP-competitive p97 inhibitor.	N2,N4-dibenzylquinazoline-2,4-diamine	0-37	melanotransferrin	Homo sapiens	116-119
21383145-4	2011	N2,N4-dibenzylquinazoline-2,4-diamine (DBeQ) was identified as a selective, potent, reversible, and ATP-competitive p97 inhibitor.	N2,N4-dibenzylquinazoline-2,4-diamine	39-43	melanotransferrin	Homo sapiens	116-119
21383145-4	2011	N2,N4-dibenzylquinazoline-2,4-diamine (DBeQ) was identified as a selective, potent, reversible, and ATP-competitive p97 inhibitor.	Adenosine Triphosphate	100-103	melanotransferrin	Homo sapiens	116-119
21383145-5	2011	DBeQ blocks multiple processes that have been shown by RNAi to depend on p97, including degradation of ubiquitin fusion degradation and endoplasmic reticulum-associated degradation pathway reporters, as well as autophagosome maturation.	N2,N4-dibenzylquinazoline-2,4-diamine	0-4	melanotransferrin	Homo sapiens	73-76
21152665-1	2011	p97 is a homohexameric, toroidal machine that harnesses the energy of ATP binding and hydrolysis to effect structural reorganization of a diverse and primarily uncharacterized set of substrate proteins.	Adenosine Triphosphate	70-73	melanotransferrin	Homo sapiens	0-3
20875789-4	2010	We previously reported that p47 phosphorylation on Serine-140 by Cdc2 results in mitotic inhibition of the p97/p47 pathway [11].	Serine	51-57	melanotransferrin	Homo sapiens	107-110
20512113-4	2010	The transition from the ADP- to the ATPgammaS-bound state is accompanied by a loop-to-helix conversion in the N-D1 linker and by an apparent re-ordering in the N-terminal region of p97.	adenosine 5'-O-(3-thiotriphosphate)	36-45	melanotransferrin	Homo sapiens	181-184
20566871-8	2010	Expression of a dominant-negative p97 ATPase did not alter levels of unprocessed Rem and SP but decreased reporter activity, suggesting p97-facilitated retrotranslocation of SP.	Protein Sorting Signals	174-176	melanotransferrin	Homo sapiens	34-37
20566871-8	2010	Expression of a dominant-negative p97 ATPase did not alter levels of unprocessed Rem and SP but decreased reporter activity, suggesting p97-facilitated retrotranslocation of SP.	Protein Sorting Signals	174-176	melanotransferrin	Homo sapiens	136-139
21351637-5	2010	At the 75th percentile food consumption level, the dietary exposure of populations to DON was higher than its TDI, 1.72 and 2.02 times (adults) as well as 1.19 and 1.09 times higher than TDI (children), respectively, based on the higher DON exposure (adults : P90 for wheat flour and P97.	deoxynivalenol	86-89	melanotransferrin	Homo sapiens	284-287
21351637-9	2010	The dietary exposure of adults to ZEN exceed the TDI, based on the average food consumption data and higher ZEN level (P99), the 75th consumption data combined with P97.	Zearalenone	34-37	melanotransferrin	Homo sapiens	165-168
20512113-0	2010	A novel ATP-dependent conformation in p97 N-D1 fragment revealed by crystal structures of disease-related mutants.	Adenosine Triphosphate	8-11	melanotransferrin	Homo sapiens	38-41
19923742-3	2009	In this work, three mutant p97 N-D1 fragments, R86A, R95G and R155H, were crystallized in the presence of ATPgammaS with PEG 3350 as a main precipitant, yielding two different crystal forms.	polyethylene glycol 3350	121-129	melanotransferrin	Homo sapiens	27-30
20512113-3	2010	The structures of p97 N-D1 fragments bearing IBMPFD mutations adopt an atypical N-domain conformation in the presence of Mg(2+).ATPgammaS, which is reversible by ADP, showing for the first time the nucleotide-dependent conformational change of the N-domain.	Magnesium	121-123	melanotransferrin	Homo sapiens	18-21
20512113-3	2010	The structures of p97 N-D1 fragments bearing IBMPFD mutations adopt an atypical N-domain conformation in the presence of Mg(2+).ATPgammaS, which is reversible by ADP, showing for the first time the nucleotide-dependent conformational change of the N-domain.	Adenosine Diphosphate	162-165	melanotransferrin	Homo sapiens	18-21
20512113-4	2010	The transition from the ADP- to the ATPgammaS-bound state is accompanied by a loop-to-helix conversion in the N-D1 linker and by an apparent re-ordering in the N-terminal region of p97.	Adenosine Diphosphate	24-27	melanotransferrin	Homo sapiens	181-184
16979249-2	2006	We have recently demonstrated, that truncated human recombinant soluble melanotransferrin (sMTf) could stimulate the activation of Plg by urokinase plasminogen activator and inhibit angiogenesis.	smtf	91-95	melanotransferrin	Homo sapiens	72-89
19553391-6	2009	P97 was also activated threefold in vitro by depletion of endogenous YY1 with wild-type, but not mutant, YY1 oligonucleotides from the IgH kappa E3" enhancer.	Oligonucleotides	109-125	melanotransferrin	Homo sapiens	0-3
18775313-1	2008	p97 is an ATP-dependent chaperone that plays an important role in endoplasmic reticulum-associated degradation but whose connections to turnover of soluble proteins remain sparse.	Adenosine Triphosphate	10-13	melanotransferrin	Homo sapiens	0-3
18575595-5	2008	APPROACH: Human p97 was covalently linked with the chemotherapeutic agents paclitaxel (PTAX) or adriamycin (ADR) and following intravenous injection, measured their penetration into brain tissue and other organs using radiolabeled and fluorescent derivatives of the drugs.	Paclitaxel	75-85	melanotransferrin	Homo sapiens	16-19
18575595-5	2008	APPROACH: Human p97 was covalently linked with the chemotherapeutic agents paclitaxel (PTAX) or adriamycin (ADR) and following intravenous injection, measured their penetration into brain tissue and other organs using radiolabeled and fluorescent derivatives of the drugs.	Paclitaxel	87-91	melanotransferrin	Homo sapiens	16-19
18575595-5	2008	APPROACH: Human p97 was covalently linked with the chemotherapeutic agents paclitaxel (PTAX) or adriamycin (ADR) and following intravenous injection, measured their penetration into brain tissue and other organs using radiolabeled and fluorescent derivatives of the drugs.	Doxorubicin	96-106	melanotransferrin	Homo sapiens	16-19
18691669-0	2008	Biochemical and spectroscopic studies of human melanotransferrin (MTf): electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins.	Iron	142-146	melanotransferrin	Homo sapiens	47-64
17449903-1	2007	Melanoma tumor antigen p97 or melanotransferrin (MTf) is an iron (Fe)-binding protein with high homology to serum transferrin.	Iron	60-64	melanotransferrin	Homo sapiens	23-26
17449903-1	2007	Melanoma tumor antigen p97 or melanotransferrin (MTf) is an iron (Fe)-binding protein with high homology to serum transferrin.	Iron	60-64	melanotransferrin	Homo sapiens	30-47
17449903-1	2007	Melanoma tumor antigen p97 or melanotransferrin (MTf) is an iron (Fe)-binding protein with high homology to serum transferrin.	Iron	60-64	melanotransferrin	Homo sapiens	49-52
17449903-1	2007	Melanoma tumor antigen p97 or melanotransferrin (MTf) is an iron (Fe)-binding protein with high homology to serum transferrin.	Iron	66-68	melanotransferrin	Homo sapiens	23-26
17449903-1	2007	Melanoma tumor antigen p97 or melanotransferrin (MTf) is an iron (Fe)-binding protein with high homology to serum transferrin.	Iron	66-68	melanotransferrin	Homo sapiens	30-47
17449903-1	2007	Melanoma tumor antigen p97 or melanotransferrin (MTf) is an iron (Fe)-binding protein with high homology to serum transferrin.	Iron	66-68	melanotransferrin	Homo sapiens	49-52
17491009-6	2007	We assigned the backbone amides of the p97 N domain and probed both its reciprocal binding surface with Npl4 UBD and its interaction with the p97-binding region of Ufd1.	Amides	25-31	melanotransferrin	Homo sapiens	39-42
17496150-7	2007	Phosphorylation of p97"s highly conserved penultimate tyrosine residue, which is the main phosphorylation site during T cell receptor stimulation, completely blocks binding of either PNGase or Ufd3 to p97.	Tyrosine	54-62	melanotransferrin	Homo sapiens	19-22
17496150-7	2007	Phosphorylation of p97"s highly conserved penultimate tyrosine residue, which is the main phosphorylation site during T cell receptor stimulation, completely blocks binding of either PNGase or Ufd3 to p97.	Tyrosine	54-62	melanotransferrin	Homo sapiens	201-204
19174149-8	2009	This novel, bipartite binding mode suggests that UBXD1 could be an efficient regulator of p97 cofactor interactions.	bipartite	12-21	melanotransferrin	Homo sapiens	90-93
18550891-5	2008	Cross-linking of intact cells with the thiol-cleavable agent dithiobis(succinimidylpropionate) (DSP), as well as nondenaturing immunoprecipitation, demonstrated an interaction between p97 and intracellular apoB.	Sulfhydryl Compounds	39-44	melanotransferrin	Homo sapiens	184-187
18550891-5	2008	Cross-linking of intact cells with the thiol-cleavable agent dithiobis(succinimidylpropionate) (DSP), as well as nondenaturing immunoprecipitation, demonstrated an interaction between p97 and intracellular apoB.	dithiobis(succinimidylpropionate)	61-93	melanotransferrin	Homo sapiens	184-187
18199748-2	2008	For many substrates, retrotranslocation requires the action of ubiquitinating enzymes, which polyubiquitinate substrates emerging from the ER lumen, and of the p97-Ufd1-Npl4 ATPase complex, which hydrolyzes ATP to dislocate polyubiquitinated substrates into the cytosol.	Adenosine Triphosphate	174-177	melanotransferrin	Homo sapiens	160-163
18691669-0	2008	Biochemical and spectroscopic studies of human melanotransferrin (MTf): electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins.	Iron	142-146	melanotransferrin	Homo sapiens	66-69
18691669-0	2008	Biochemical and spectroscopic studies of human melanotransferrin (MTf): electron-paramagnetic resonance evidence for a difference between the iron-binding site of MTf and other transferrins.	Iron	142-146	melanotransferrin	Homo sapiens	163-166
18691669-1	2008	Melanotransferrin (MTf) is a member of the transferrin (Tf) family of iron (Fe)-binding proteins that was first identified as a cell-surface marker of melanoma.	Iron	70-74	melanotransferrin	Homo sapiens	0-17
18691669-1	2008	Melanotransferrin (MTf) is a member of the transferrin (Tf) family of iron (Fe)-binding proteins that was first identified as a cell-surface marker of melanoma.	Iron	70-74	melanotransferrin	Homo sapiens	19-22
18691669-1	2008	Melanotransferrin (MTf) is a member of the transferrin (Tf) family of iron (Fe)-binding proteins that was first identified as a cell-surface marker of melanoma.	Iron	76-78	melanotransferrin	Homo sapiens	0-17
18691669-1	2008	Melanotransferrin (MTf) is a member of the transferrin (Tf) family of iron (Fe)-binding proteins that was first identified as a cell-surface marker of melanoma.	Iron	76-78	melanotransferrin	Homo sapiens	19-22
18691669-2	2008	Although MTf has a high-affinity Fe-binding site that is practically identical to that of serum Tf, the protein does not play an essential role in Fe homeostasis and its precise molecular function remains unclear.	Iron	33-35	melanotransferrin	Homo sapiens	9-12
18691669-3	2008	A Zn(II)-binding motif, distinct from the Fe-binding site, has been proposed in human MTf based on computer modelling studies.	Zinc	2-8	melanotransferrin	Homo sapiens	86-89
18691669-3	2008	A Zn(II)-binding motif, distinct from the Fe-binding site, has been proposed in human MTf based on computer modelling studies.	Iron	42-44	melanotransferrin	Homo sapiens	86-89
18691669-5	2008	For the first time, biochemical and spectroscopic techniques have been used in this study to characterise metal ion-binding to recombinant MTf.	Metals	106-111	melanotransferrin	Homo sapiens	139-142
18691669-6	2008	Initially, the binding of Fe to MTf was examined using 6M urea gel electrophoresis.	Iron	26-28	melanotransferrin	Homo sapiens	32-35
18691669-6	2008	Initially, the binding of Fe to MTf was examined using 6M urea gel electrophoresis.	Urea	58-62	melanotransferrin	Homo sapiens	32-35
18691669-8	2008	The presence of a single Fe(III)-binding site was also supported by EPR results which indicated that the Fe(III)-binding characteristics of MTf were unique, but somewhat comparable to the N-lobes of human serum Tf and chicken ovo-Tf.	ferric sulfate	25-32	melanotransferrin	Homo sapiens	140-143
18691669-8	2008	The presence of a single Fe(III)-binding site was also supported by EPR results which indicated that the Fe(III)-binding characteristics of MTf were unique, but somewhat comparable to the N-lobes of human serum Tf and chicken ovo-Tf.	ferric sulfate	105-112	melanotransferrin	Homo sapiens	140-143
18691669-10	2008	The ability of MTf to bind Zn(II) was also investigated using CD which demonstrated that the single high-affinity Fe-binding site was distinct from a potential Zn(II)-binding site.	Zinc	27-33	melanotransferrin	Homo sapiens	15-18
18691669-10	2008	The ability of MTf to bind Zn(II) was also investigated using CD which demonstrated that the single high-affinity Fe-binding site was distinct from a potential Zn(II)-binding site.	Iron	114-116	melanotransferrin	Homo sapiens	15-18
16092934-8	2005	[3H]Nisoxetine binding affinities were decreased 13-fold for hP97C and 5-fold for hF101C.	Tritium	1-4	melanotransferrin	Homo sapiens	61-65
16818506-0	2006	Potent cytotoxicity of an auristatin-containing antibody-drug conjugate targeting melanoma cells expressing melanotransferrin/p97.	auristatin	26-36	melanotransferrin	Homo sapiens	108-125
16818506-0	2006	Potent cytotoxicity of an auristatin-containing antibody-drug conjugate targeting melanoma cells expressing melanotransferrin/p97.	auristatin	26-36	melanotransferrin	Homo sapiens	126-129
16807242-2	2006	Specific p97 functions are mediated by a variety of cofactors, among them peptide N-glycanase, an enzyme that removes glycans from misfolded glycoproteins.	Polysaccharides	118-125	melanotransferrin	Homo sapiens	9-12
16092934-8	2005	[3H]Nisoxetine binding affinities were decreased 13-fold for hP97C and 5-fold for hF101C.	nisoxetine	4-14	melanotransferrin	Homo sapiens	61-65
15698559-1	2005	In this issue of Structure, Davies et al., 2005, present shape reconstructions for the molecular motor p97 using small angle X-ray scattering (SAXS) and offer insights into how ATP consumption is coupled to cyclical domain motions.	Adenosine Triphosphate	177-180	melanotransferrin	Homo sapiens	103-106
15843038-1	2005	We have previously demonstrated that human recombinant soluble melanotransferrin (hr-sMTf) interacts with the single-chain zymogen pro urokinase-type plasminogen activator (scu-PA) and plasminogen.	hr-smtf	82-89	melanotransferrin	Homo sapiens	63-80
15716025-3	2005	However, human MTf has only a single, high affinity, Fe-binding site.	Iron	53-55	melanotransferrin	Homo sapiens	15-18
15716025-4	2005	Furthermore, while isolated MTf can bind Fe, it plays little role in Fe uptake by cells and its function remains elusive.	Iron	41-43	melanotransferrin	Homo sapiens	28-31
15705575-0	2005	Calorimetric studies of melanotransferrin (p97) and its interaction with iron.	Iron	73-77	melanotransferrin	Homo sapiens	24-41
15705575-0	2005	Calorimetric studies of melanotransferrin (p97) and its interaction with iron.	Iron	73-77	melanotransferrin	Homo sapiens	43-46
12713171-3	2003	The result showed that P97/302 IBDV was most identical to the reported very virulent IBDV strains because it has amino acid substitutions at positions 222, 256, 294, and 299, which encode alanine, isoleucine, isoleucine, and serine, respectively.	Alanine	188-195	melanotransferrin	Homo sapiens	23-30
12634057-2	2003	We present the cryo-electron microscopy three-dimensional reconstruction of endogenous p97 in an AMP-PNP bound state at 24 A resolution.	Adenylyl Imidodiphosphate	97-104	melanotransferrin	Homo sapiens	87-90
12634057-4	2003	The docking of the X-ray structure of N-D1 domains in an ADP bound state indicates that an upward repositioning of N domain is necessary to accommodate the cryo-EM map of "p97-AMP-PNP", suggesting a change in the orientation of N domains upon nucleotide hydrolysis.	Adenosine Diphosphate	57-60	melanotransferrin	Homo sapiens	172-175
12634057-4	2003	The docking of the X-ray structure of N-D1 domains in an ADP bound state indicates that an upward repositioning of N domain is necessary to accommodate the cryo-EM map of "p97-AMP-PNP", suggesting a change in the orientation of N domains upon nucleotide hydrolysis.	Adenosine Monophosphate	176-179	melanotransferrin	Homo sapiens	172-175
14766298-0	2004	Deletion of the GPI pre-anchor sequence in human p97--a general approach for generating the soluble form of GPI-linked proteins.	Glycosylphosphatidylinositols	16-19	melanotransferrin	Homo sapiens	49-52
14766298-1	2004	Melanotransferrin, also named p97, belongs to the transferrin-like group of iron-binding proteins.	Iron	76-80	melanotransferrin	Homo sapiens	0-17
14766298-1	2004	Melanotransferrin, also named p97, belongs to the transferrin-like group of iron-binding proteins.	Iron	76-80	melanotransferrin	Homo sapiens	30-33
14766298-2	2004	Unlike the other members of this family, p97 exists in two forms-one soluble form and one attached to the cell membrane by a glycosylphosphatidylinositol (GPI) anchor.	Glycosylphosphatidylinositols	125-153	melanotransferrin	Homo sapiens	41-44
14766298-2	2004	Unlike the other members of this family, p97 exists in two forms-one soluble form and one attached to the cell membrane by a glycosylphosphatidylinositol (GPI) anchor.	Glycosylphosphatidylinositols	155-158	melanotransferrin	Homo sapiens	41-44
14617820-9	2004	More specific assessment of effects of p97(E578Q) on organelle assembly shows that the Golgi apparatus disperses and reassembles normally after treatment with brefeldin A and during mitosis.	Brefeldin A	159-170	melanotransferrin	Homo sapiens	39-42
14617820-10	2004	These findings demonstrate that ATP-hydrolysis-dependent activities of NSF and p97 in the cell are not equivalent and suggest that only NSF is directly involved in regulating membrane fusion.	Adenosine Triphosphate	32-35	melanotransferrin	Homo sapiens	79-82
14745458-1	2003	OBJECTIVE: This study was undertaken to assess the role of p97 (also known as melanotransferrin) in the transfer of iron into the brain, because the passage of most large molecules is limited by the presence of the blood-brain barrier, including that of the serum iron transporter transferrin.	Iron	116-120	melanotransferrin	Homo sapiens	59-62
14745458-1	2003	OBJECTIVE: This study was undertaken to assess the role of p97 (also known as melanotransferrin) in the transfer of iron into the brain, because the passage of most large molecules is limited by the presence of the blood-brain barrier, including that of the serum iron transporter transferrin.	Iron	116-120	melanotransferrin	Homo sapiens	78-95
14745458-4	2003	We also provide evidence that p97 transports iron into the brain more efficiently than transferrin.	Iron	45-49	melanotransferrin	Homo sapiens	30-33
14745458-5	2003	CONCLUSIONS: These data support the idea that p97 is an important iron transporter across the blood-brain barrier in normal physiology and possibly in neurodegenerative diseases, such as Alzheimer disease, in which iron homeostasis in the brain becomes disrupted.	Iron	66-70	melanotransferrin	Homo sapiens	46-49
12809550-3	2003	To clarify the correlation between melanotransferrin and Alzheimer"s disease, the melanotransferrin content was determined by non-reducing, denaturing SDS/PAGE and Western blotting.	Sodium Dodecyl Sulfate	151-154	melanotransferrin	Homo sapiens	82-99
12809550-5	2003	Melanotransferrin antigenicity and the relative proportions of the two forms were very sensitive to factors that altered its conformation, including disulphide bridges, pH and bivalent cations.	disulphide	149-159	melanotransferrin	Homo sapiens	0-17
12713171-3	2003	The result showed that P97/302 IBDV was most identical to the reported very virulent IBDV strains because it has amino acid substitutions at positions 222, 256, 294, and 299, which encode alanine, isoleucine, isoleucine, and serine, respectively.	Isoleucine	197-207	melanotransferrin	Homo sapiens	23-30
12713171-3	2003	The result showed that P97/302 IBDV was most identical to the reported very virulent IBDV strains because it has amino acid substitutions at positions 222, 256, 294, and 299, which encode alanine, isoleucine, isoleucine, and serine, respectively.	Isoleucine	209-219	melanotransferrin	Homo sapiens	23-30
12713171-3	2003	The result showed that P97/302 IBDV was most identical to the reported very virulent IBDV strains because it has amino acid substitutions at positions 222, 256, 294, and 299, which encode alanine, isoleucine, isoleucine, and serine, respectively.	Serine	225-231	melanotransferrin	Homo sapiens	23-30
12473691-4	2002	Now we have identified a novel essential factor for p97/p47-mediated membrane fusion, named VCIP135 (valosin-containing protein [VCP][p97]/p47 complex-interacting protein, p135), and show that it binds to the p97/p47/syntaxin5 complex and dissociates it via p97 catalyzed ATP hydrolysis.	Adenosine Triphosphate	272-275	melanotransferrin	Homo sapiens	52-55
12473691-4	2002	Now we have identified a novel essential factor for p97/p47-mediated membrane fusion, named VCIP135 (valosin-containing protein [VCP][p97]/p47 complex-interacting protein, p135), and show that it binds to the p97/p47/syntaxin5 complex and dissociates it via p97 catalyzed ATP hydrolysis.	Adenosine Triphosphate	272-275	melanotransferrin	Homo sapiens	134-137
12473691-4	2002	Now we have identified a novel essential factor for p97/p47-mediated membrane fusion, named VCIP135 (valosin-containing protein [VCP][p97]/p47 complex-interacting protein, p135), and show that it binds to the p97/p47/syntaxin5 complex and dissociates it via p97 catalyzed ATP hydrolysis.	Adenosine Triphosphate	272-275	melanotransferrin	Homo sapiens	134-137
12473691-4	2002	Now we have identified a novel essential factor for p97/p47-mediated membrane fusion, named VCIP135 (valosin-containing protein [VCP][p97]/p47 complex-interacting protein, p135), and show that it binds to the p97/p47/syntaxin5 complex and dissociates it via p97 catalyzed ATP hydrolysis.	Adenosine Triphosphate	272-275	melanotransferrin	Homo sapiens	134-137
12146947-0	2002	Phospholipid species act as modulators in p97/p47-mediated fusion of Golgi membranes.	Phospholipids	0-12	melanotransferrin	Homo sapiens	42-45
12230555-0	2002	The soluble form of the membrane-bound transferrin homologue, melanotransferrin, inefficiently donates iron to cells via nonspecific internalization and degradation of the protein.	Iron	103-107	melanotransferrin	Homo sapiens	62-79
12146947-4	2002	Using model membranes, we demonstrate a PE-dependent recruitment of p97/p47 to membranes, causing dramatic conformational rearrangements and favoring protein-lipid interactions.	phosphatidylethanolamine	40-42	melanotransferrin	Homo sapiens	68-71
12146947-8	2002	Importantly, PE-mediated changes in secondary and tertiary structures are exclusively observed when p97 is complexed with p47, which is a prerequisite for membrane fusion.	phosphatidylethanolamine	13-15	melanotransferrin	Homo sapiens	100-103
12146947-9	2002	We therefore propose that at physiological conditions PE-induced conformational changes in p97/p47 are relevant in triggering this activity.	phosphatidylethanolamine	54-56	melanotransferrin	Homo sapiens	91-94
12214055-3	2001	Our studies have demonstrated that the level of the iron transport protein, p97, is increased in the serum of AD patients but not in various control groups.	Iron	52-56	melanotransferrin	Homo sapiens	76-79
12688510-0	2002	Iron uptake by melanoma cells from the soluble form of the transferrin homologue, melanotransferrin.	Iron	0-4	melanotransferrin	Homo sapiens	82-99
11815303-3	2002	Our studies have demonstrated that the level of the iron transport protein, p97, is increased in the serum of AD patients but not in various control groups.	Iron	52-56	melanotransferrin	Homo sapiens	76-79
11815303-6	2002	Although the relationship between increased level of iron and p97 in the AD brain is not well understood, our research supports the hypothesis that p97 over-expressed by senile plaque associated reactive microglia is exocytosed and appears in blood.	Iron	53-57	melanotransferrin	Homo sapiens	62-65
11815303-6	2002	Although the relationship between increased level of iron and p97 in the AD brain is not well understood, our research supports the hypothesis that p97 over-expressed by senile plaque associated reactive microglia is exocytosed and appears in blood.	Iron	53-57	melanotransferrin	Homo sapiens	148-151
12214055-6	2001	Although the relationship between increased level of iron and p97 in the AD brain is not well understood, our research supports the hypothesis that p97 over-expressed by senile plaque associated reactive microglia is exocytosed and appears in blood.	Iron	53-57	melanotransferrin	Homo sapiens	62-65
12214055-6	2001	Although the relationship between increased level of iron and p97 in the AD brain is not well understood, our research supports the hypothesis that p97 over-expressed by senile plaque associated reactive microglia is exocytosed and appears in blood.	Iron	53-57	melanotransferrin	Homo sapiens	148-151
10092489-1	1999	The ability of several lepidopteran and dipteran insect cell lines to express human melanotransferrin (p97), a glycosyl phosphatidylinositol (GPI)-anchored, iron-binding sialoglycoprotein, was assessed.	Glycosylphosphatidylinositols	111-140	melanotransferrin	Homo sapiens	84-101
11087817-0	2000	Tyrosine phosphorylation of p97 regulates transitional endoplasmic reticulum assembly in vitro.	Tyrosine	0-8	melanotransferrin	Homo sapiens	28-31
11087817-3	2000	Incubation with the PTPase inhibitor bpV(phen) inhibited tER assembly coincident with the enhanced tyrosine phosphorylation of endogenous p97 and its release from membranes.	bromopyruvate	37-40	melanotransferrin	Homo sapiens	138-141
11087817-3	2000	Incubation with the PTPase inhibitor bpV(phen) inhibited tER assembly coincident with the enhanced tyrosine phosphorylation of endogenous p97 and its release from membranes.	1,10-phenanthroline	41-45	melanotransferrin	Homo sapiens	138-141
11033347-2	2000	MTf has many characteristics in common with serum Tf and previous studies have shown that it can bind Fe.	Iron	102-104	melanotransferrin	Homo sapiens	0-3
11033347-3	2000	This has led to speculation that MTf may be involved in Fe transport.	Iron	56-58	melanotransferrin	Homo sapiens	33-36
11033347-4	2000	Because Fe is required for a variety of metabolic reactions including ATP and DNA synthesis, MTf could play a role in proliferation.	Iron	8-10	melanotransferrin	Homo sapiens	93-96
11033347-4	2000	Because Fe is required for a variety of metabolic reactions including ATP and DNA synthesis, MTf could play a role in proliferation.	Adenosine Triphosphate	70-73	melanotransferrin	Homo sapiens	93-96
10872750-3	2000	Iron sequestering molecules, such as ferritin, transferrin, lactotransferrin, melanotransferrin, hemosiderin and heme can serve as cytoprotectants against metal-mediated oxidant damage.	Iron	0-4	melanotransferrin	Homo sapiens	78-95
10872750-3	2000	Iron sequestering molecules, such as ferritin, transferrin, lactotransferrin, melanotransferrin, hemosiderin and heme can serve as cytoprotectants against metal-mediated oxidant damage.	Metals	155-160	melanotransferrin	Homo sapiens	78-95
10691965-0	2000	The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell.	Iron	75-79	melanotransferrin	Homo sapiens	47-64
10691965-0	2000	The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell.	Iron	75-79	melanotransferrin	Homo sapiens	66-69
10691965-2	2000	MTf is found at high levels in melanoma cells and previous studies have shown that MTf can bind Fe.	Iron	96-98	melanotransferrin	Homo sapiens	0-3
10691965-2	2000	MTf is found at high levels in melanoma cells and previous studies have shown that MTf can bind Fe.	Iron	96-98	melanotransferrin	Homo sapiens	83-86
10691965-3	2000	In addition, Chinese hamster ovary cells transfected with MTf transport Fe from 59Fe-citrate at greater rates than control cells.	Iron	72-74	melanotransferrin	Homo sapiens	58-61
10691965-3	2000	In addition, Chinese hamster ovary cells transfected with MTf transport Fe from 59Fe-citrate at greater rates than control cells.	59fe-citrate	80-92	melanotransferrin	Homo sapiens	58-61
10691965-5	2000	In the present study we have characterized the role of MTf in Fe uptake by SK-Mel-28 melanoma cells in order to understand its function.	Iron	62-64	melanotransferrin	Homo sapiens	55-58
10691965-6	2000	Initial studies examined whether modulation of intracellular Fe levels using the Fe chelator desferrioxamine (DFO) or the Fe donor ferric ammonium citrate (FAC) could change MTf mRNA levels.	Iron	61-63	melanotransferrin	Homo sapiens	174-177
10691965-6	2000	Initial studies examined whether modulation of intracellular Fe levels using the Fe chelator desferrioxamine (DFO) or the Fe donor ferric ammonium citrate (FAC) could change MTf mRNA levels.	Deferoxamine	110-113	melanotransferrin	Homo sapiens	174-177
10691965-6	2000	Initial studies examined whether modulation of intracellular Fe levels using the Fe chelator desferrioxamine (DFO) or the Fe donor ferric ammonium citrate (FAC) could change MTf mRNA levels.	ferric ammonium citrate	131-154	melanotransferrin	Homo sapiens	174-177
10691965-9	2000	Further studies examined the ability of DFO and FAC to modulate Fe uptake from 59Fe-citrate which is bound by MTf.	Iron	64-66	melanotransferrin	Homo sapiens	110-113
10691965-9	2000	Further studies examined the ability of DFO and FAC to modulate Fe uptake from 59Fe-citrate which is bound by MTf.	59fe-citrate	79-91	melanotransferrin	Homo sapiens	110-113
10691965-12	2000	MTf can be removed from the membrane by phosphatidylinositol-specific phospholipase C (PtdIns-PLC).	Phosphatidylinositols	40-60	melanotransferrin	Homo sapiens	0-3
10691965-14	2000	These results suggest that MTf played only a minor role in Fe uptake from 59Fe-citrate by these cells.	Iron	59-61	melanotransferrin	Homo sapiens	27-30
10691965-14	2000	These results suggest that MTf played only a minor role in Fe uptake from 59Fe-citrate by these cells.	Citric Acid	79-86	melanotransferrin	Homo sapiens	27-30
10813095-0	2000	Role of melanotransferrin (p97) in non-transferrin iron uptake by HeLa and K562 cells.	Iron	51-55	melanotransferrin	Homo sapiens	8-25
10813095-0	2000	Role of melanotransferrin (p97) in non-transferrin iron uptake by HeLa and K562 cells.	Iron	51-55	melanotransferrin	Homo sapiens	27-30
10813095-1	2000	We tested whether melanotransferrin (p97), an iron-binding protein of the plasma membrane, is involved in the transport of non-transferrin iron into human HeLa and K562 cells.	Iron	46-50	melanotransferrin	Homo sapiens	18-35
10813095-1	2000	We tested whether melanotransferrin (p97), an iron-binding protein of the plasma membrane, is involved in the transport of non-transferrin iron into human HeLa and K562 cells.	Iron	46-50	melanotransferrin	Homo sapiens	37-40
10813095-1	2000	We tested whether melanotransferrin (p97), an iron-binding protein of the plasma membrane, is involved in the transport of non-transferrin iron into human HeLa and K562 cells.	Iron	139-143	melanotransferrin	Homo sapiens	18-35
10813095-1	2000	We tested whether melanotransferrin (p97), an iron-binding protein of the plasma membrane, is involved in the transport of non-transferrin iron into human HeLa and K562 cells.	Iron	139-143	melanotransferrin	Homo sapiens	37-40
10529437-12	1999	Thus, p97 is a unique cellular hallmark of AD and further suggests that metal transport mechanisms play a role in this disease.	Metals	72-77	melanotransferrin	Homo sapiens	6-9
10402460-2	1999	A cell-free system that reconstructs these events has revealed that cisternal regrowth requires interplay between soluble factors and soluble N-ethylmaleimide (NEM)-sensitive fusion protein (NSF) attachment protein receptors (SNAREs) via two intersecting pathways controlled by the ATPases, p97 and NSF.	Ethylmaleimide	142-158	melanotransferrin	Homo sapiens	291-294
10402460-2	1999	A cell-free system that reconstructs these events has revealed that cisternal regrowth requires interplay between soluble factors and soluble N-ethylmaleimide (NEM)-sensitive fusion protein (NSF) attachment protein receptors (SNAREs) via two intersecting pathways controlled by the ATPases, p97 and NSF.	Ethylmaleimide	160-163	melanotransferrin	Homo sapiens	291-294
10205162-5	1999	Using purified protein, p97 or NSF was found to be sufficient to mediate rapid fusion in an ATP-dependent manner.	Adenosine Triphosphate	92-95	melanotransferrin	Homo sapiens	24-27
10205162-10	1999	We conclude from these data that p97, NSF and perhaps other related ATPases catalyse rapid and complete fusion between lipid bilayers on opposing membranes.	Lipid Bilayers	119-133	melanotransferrin	Homo sapiens	33-36
11087817-3	2000	Incubation with the PTPase inhibitor bpV(phen) inhibited tER assembly coincident with the enhanced tyrosine phosphorylation of endogenous p97 and its release from membranes.	Tyrosine	99-107	melanotransferrin	Homo sapiens	138-141
11087817-4	2000	By contrast, the tyrosine kinase inhibitor, genistein, promoted tER formation and prevented p97 dissociation from membranes while increasing p97 association with the t-SNARE syntaxin 5.	Genistein	44-53	melanotransferrin	Homo sapiens	92-95
11087817-4	2000	By contrast, the tyrosine kinase inhibitor, genistein, promoted tER formation and prevented p97 dissociation from membranes while increasing p97 association with the t-SNARE syntaxin 5.	Genistein	44-53	melanotransferrin	Homo sapiens	141-144
11087817-6	2000	The p97 tyrosine phosphorylation state is proposed to coordinate the assembly of the tER as a regulatory step of the early secretory pathway.	Tyrosine	8-16	melanotransferrin	Homo sapiens	4-7
11163220-0	2000	A major conformational change in p97 AAA ATPase upon ATP binding.	Adenosine Triphosphate	41-44	melanotransferrin	Homo sapiens	33-36
10092489-1	1999	The ability of several lepidopteran and dipteran insect cell lines to express human melanotransferrin (p97), a glycosyl phosphatidylinositol (GPI)-anchored, iron-binding sialoglycoprotein, was assessed.	Glycosylphosphatidylinositols	111-140	melanotransferrin	Homo sapiens	103-106
10092489-2	1999	Spodoptera frugiperda-derived (Sf9) cell lines, transformed with the p97 gene under control of a baculovirus immediate-early promoter, were able to constitutively express the protein and correctly attach it to the outer cell membrane via a GPI anchor as demonstrated by PI-PLC treatment.	Glycosylphosphatidylinositols	240-243	melanotransferrin	Homo sapiens	69-72
9885561-3	1998	Upon cytokine, growth factor, or antigen receptor stimulation, p97 becomes tyrosyl phosphorylated and associates with several SH2 domain-containing proteins, including SHP2.	cyclo(tyrosyl-tyrosyl)	75-82	melanotransferrin	Homo sapiens	63-66
9201707-5	1997	The pore complex-binding domain overlaps the Ran-GTP- and Ran-GDP-binding domains on p97, but only Ran-GTP competes for docking in permeabilized cells.	Guanosine Diphosphate	62-65	melanotransferrin	Homo sapiens	85-88
9729418-1	1998	New findings on the role of LfR (lactotransferrin receptor), MTf (melanotransferrin), CP (ceruloplasmin) and DCT1 (Divalent Cation Transporter) in brain iron transport, obtained during the past 3 years, are important advances in the fields of physiology and pathophysiology of brain iron metabolism.	Iron	153-157	melanotransferrin	Homo sapiens	66-83
18636451-1	1997	Chinese hamster ovary (CHO) cells expressing the human melanoma tumour antigen, p97, were used to develop a controlled release process for the production of recombinant glycosyl-phosphatidylinositol (GPI) anchored proteins.	Glycosylphosphatidylinositols	169-198	melanotransferrin	Homo sapiens	80-83
18636451-1	1997	Chinese hamster ovary (CHO) cells expressing the human melanoma tumour antigen, p97, were used to develop a controlled release process for the production of recombinant glycosyl-phosphatidylinositol (GPI) anchored proteins.	Glycosylphosphatidylinositols	200-203	melanotransferrin	Homo sapiens	80-83
9201707-5	1997	The pore complex-binding domain overlaps the Ran-GTP- and Ran-GDP-binding domains on p97, but only Ran-GTP competes for docking in permeabilized cells.	Guanosine Triphosphate	49-52	melanotransferrin	Homo sapiens	85-88
8909533-7	1996	In solution binding assays, Ran-GTP bound p97 with high affinity, but the binding of Ran-GDP to p97 was undetectable.	Guanosine Triphosphate	32-35	melanotransferrin	Homo sapiens	42-45
9045717-0	1997	Different binding domains for Ran-GTP and Ran-GDP/RanBP1 on nuclear import factor p97.	Ranitidine	30-33	melanotransferrin	Homo sapiens	82-85
9045717-3	1997	Ran-GTP alone binds p97, but Ran-GDP binds p97 only in conjunction with RanBP1.	ran-gtp	0-7	melanotransferrin	Homo sapiens	20-23
9045717-3	1997	Ran-GTP alone binds p97, but Ran-GDP binds p97 only in conjunction with RanBP1.	Guanosine Diphosphate	33-36	melanotransferrin	Homo sapiens	43-46
9045717-4	1997	Using site-directed mutagenesis and deletion analysis, we have identified two distinct but overlapping binding domains for Ran-GTP and Ran-GDP/RanBP1 on p97.	ran-gtp	123-130	melanotransferrin	Homo sapiens	153-156
9045717-6	1997	A conserved cysteine residue in p97, Cys-158, is required for binding Ran-GDP/RanBP1, but not for binding of Ran-GTP to p97.	Cysteine	12-20	melanotransferrin	Homo sapiens	32-35
9045717-6	1997	A conserved cysteine residue in p97, Cys-158, is required for binding Ran-GDP/RanBP1, but not for binding of Ran-GTP to p97.	Cysteine	37-40	melanotransferrin	Homo sapiens	32-35
9201707-6	1997	The N-ethylmaleimide sensitivity of the p97 for docking was investigated and found to be due to inhibition of p97 binding to the pore complex and to the NLS receptor.	Ethylmaleimide	4-20	melanotransferrin	Homo sapiens	40-43
9201707-6	1997	The N-ethylmaleimide sensitivity of the p97 for docking was investigated and found to be due to inhibition of p97 binding to the pore complex and to the NLS receptor.	Ethylmaleimide	4-20	melanotransferrin	Homo sapiens	110-113
9201707-7	1997	Site-directed mutagenesis of conserved cysteine residues in the pore- and receptor-binding domains identified two cysteines, C223 and C228, that were required for p97 to bind the nuclear pore.	Cysteine	39-47	melanotransferrin	Homo sapiens	163-166
9201707-7	1997	Site-directed mutagenesis of conserved cysteine residues in the pore- and receptor-binding domains identified two cysteines, C223 and C228, that were required for p97 to bind the nuclear pore.	Cysteine	114-123	melanotransferrin	Homo sapiens	163-166
8909533-7	1996	In solution binding assays, Ran-GTP bound p97 with high affinity, but the binding of Ran-GDP to p97 was undetectable.	Guanosine Diphosphate	89-92	melanotransferrin	Homo sapiens	96-99
8909533-8	1996	The addition of RanBP1 with Ran-GDP or Ran-GTP increased the affinity of both forms of Ran for p97 to the same level.	Guanosine Diphosphate	32-35	melanotransferrin	Homo sapiens	95-98
8909533-12	1996	These results suggest that RanBP1 promotes both the docking and translocation steps in nuclear protein import by stabilizing the interaction of Ran-GDP with p97.	Guanosine Diphosphate	148-151	melanotransferrin	Homo sapiens	157-160
15157460-4	1996	Specifically, iron uptake by the cell-surface GPI-linked traps ferrin homologue, melanotransferrin or p97, is described and possible functions of this traps ferrin-independent pathway are proposed.	Iron	14-18	melanotransferrin	Homo sapiens	81-98
8898750-0	1996	Serum levels of the iron binding protein p97 are elevated in Alzheimer"s disease.	Iron	20-24	melanotransferrin	Homo sapiens	41-44
8898750-4	1996	Here we provide evidence that the soluble form of the iron binding protein p97 is found in elevated amounts in the serum of Alzheimer"s patients compared with healthy controls.	Iron	54-58	melanotransferrin	Homo sapiens	75-78
8755535-5	1996	By preloading recombinant Ran/TC4 with [gamma-32P]GTP or [3H]GDP, we show that the interactions with p97 and NTF2 are specific for the GTP- and GDP-bound forms, respectively.	GTP-Gamma-32P	39-53	melanotransferrin	Homo sapiens	101-104
8755535-5	1996	By preloading recombinant Ran/TC4 with [gamma-32P]GTP or [3H]GDP, we show that the interactions with p97 and NTF2 are specific for the GTP- and GDP-bound forms, respectively.	Tritium	58-60	melanotransferrin	Homo sapiens	101-104
8755535-5	1996	By preloading recombinant Ran/TC4 with [gamma-32P]GTP or [3H]GDP, we show that the interactions with p97 and NTF2 are specific for the GTP- and GDP-bound forms, respectively.	Guanosine Diphosphate	61-64	melanotransferrin	Homo sapiens	101-104
8755535-5	1996	By preloading recombinant Ran/TC4 with [gamma-32P]GTP or [3H]GDP, we show that the interactions with p97 and NTF2 are specific for the GTP- and GDP-bound forms, respectively.	Guanosine Triphosphate	50-53	melanotransferrin	Homo sapiens	101-104
8755535-5	1996	By preloading recombinant Ran/TC4 with [gamma-32P]GTP or [3H]GDP, we show that the interactions with p97 and NTF2 are specific for the GTP- and GDP-bound forms, respectively.	Guanosine Diphosphate	144-147	melanotransferrin	Homo sapiens	101-104
8755535-6	1996	These data together with previous studies lead us to suggest that the interaction of the GTP-bound form of Ran/TC4 with p97 is linked to an early step in the nuclear protein import pathway and that the association of the GDP-bound form of Ran/TC4 with NTF2 helps define vectorial transport.	Guanosine Triphosphate	89-92	melanotransferrin	Homo sapiens	120-123
15157460-4	1996	Specifically, iron uptake by the cell-surface GPI-linked traps ferrin homologue, melanotransferrin or p97, is described and possible functions of this traps ferrin-independent pathway are proposed.	Iron	14-18	melanotransferrin	Homo sapiens	102-105
15157460-4	1996	Specifically, iron uptake by the cell-surface GPI-linked traps ferrin homologue, melanotransferrin or p97, is described and possible functions of this traps ferrin-independent pathway are proposed.	ferrin	63-69	melanotransferrin	Homo sapiens	81-98
15157460-4	1996	Specifically, iron uptake by the cell-surface GPI-linked traps ferrin homologue, melanotransferrin or p97, is described and possible functions of this traps ferrin-independent pathway are proposed.	ferrin	63-69	melanotransferrin	Homo sapiens	102-105
7553850-4	1995	We now provide evidence that the sequential stack formation from VGMs reflects two distinct fusion processes: the first event is N-ethyl-maleimide (NEM)-sensitive factor (NSF) dependent, and the second fusion event requires an NSF-like NEM-sensitive ATPase called p97.	Ethylmaleimide	129-146	melanotransferrin	Homo sapiens	264-267
8705293-3	1996	MTf has a high level of sequence homology to transferrin (Tf) and lactoferrin, but is unusual because it predominantly occurs as a membrane bound, glycosylphosphatidylinositol (GPI) anchored molecule, but can also occur as a soluble form.	Glycosylphosphatidylinositols	147-175	melanotransferrin	Homo sapiens	0-3
8705293-3	1996	MTf has a high level of sequence homology to transferrin (Tf) and lactoferrin, but is unusual because it predominantly occurs as a membrane bound, glycosylphosphatidylinositol (GPI) anchored molecule, but can also occur as a soluble form.	Glycosylphosphatidylinositols	177-180	melanotransferrin	Homo sapiens	0-3
8705293-4	1996	We have recently demonstrated that GPI-anchored MTf provides a novel route for cellular iron uptake which is independent of Tf and its receptor.	Iron	88-92	melanotransferrin	Homo sapiens	48-51
8705293-5	1996	Here we consider whether MTf may have a role in the transport of iron across the BBB.	Iron	65-69	melanotransferrin	Homo sapiens	25-28
8705293-9	1996	These data suggest that MTf may play a role in iron transport within the human brain.	Iron	47-51	melanotransferrin	Homo sapiens	24-27
8705294-3	1996	We have identified a novel pathway of iron uptake into mammalian cells involving melanotransferrin, or p97, which is independent of the transferrin receptor.	Iron	38-42	melanotransferrin	Homo sapiens	81-98
8705294-3	1996	We have identified a novel pathway of iron uptake into mammalian cells involving melanotransferrin, or p97, which is independent of the transferrin receptor.	Iron	38-42	melanotransferrin	Homo sapiens	103-106
8705294-8	1996	Our demonstration that melanotransferrin mediates iron uptake through a pathway independent of the transferrin receptor indicates that this mechanism may have a role in AD.	Iron	50-54	melanotransferrin	Homo sapiens	23-40
7556058-0	1995	A novel iron uptake mechanism mediated by GPI-anchored human p97.	Iron	8-12	melanotransferrin	Homo sapiens	61-64
7556058-0	1995	A novel iron uptake mechanism mediated by GPI-anchored human p97.	Glycosylphosphatidylinositols	42-45	melanotransferrin	Homo sapiens	61-64
7556058-5	1995	Treatment of the cells with either phosphatidylinositol-phospholipase C or monoclonal antibodies against p97 resulted in over a 50% reduction and a 47% increase in the iron uptake respectively.	Iron	168-172	melanotransferrin	Homo sapiens	105-108
7556058-2	1995	Here, the role of the glycosyl-phosphatidylinositol (GPI)-linked transferrin homologue, melanotransferrin or p97, was studied using CHO cell lines defective in the transferrin receptor (TR) and transfected with human TR and/or human p97.	Glycosylphosphatidylinositols	53-56	melanotransferrin	Homo sapiens	109-112
7556058-6	1995	These data identify p97 as a unique cell surface GPI-anchored, iron binding protein involved in the transferrin-independent uptake of iron in mammals.	Glycosylphosphatidylinositols	49-52	melanotransferrin	Homo sapiens	20-23
7556058-3	1995	The presence of p97 doubled the iron uptake, which could be explained by the binding of one atom of iron to one molecule of p97.	Iron	32-36	melanotransferrin	Homo sapiens	16-19
7556058-6	1995	These data identify p97 as a unique cell surface GPI-anchored, iron binding protein involved in the transferrin-independent uptake of iron in mammals.	Iron	63-67	melanotransferrin	Homo sapiens	20-23
7556058-3	1995	The presence of p97 doubled the iron uptake, which could be explained by the binding of one atom of iron to one molecule of p97.	Iron	32-36	melanotransferrin	Homo sapiens	124-127
7556058-6	1995	These data identify p97 as a unique cell surface GPI-anchored, iron binding protein involved in the transferrin-independent uptake of iron in mammals.	Iron	134-138	melanotransferrin	Homo sapiens	20-23
7556058-3	1995	The presence of p97 doubled the iron uptake, which could be explained by the binding of one atom of iron to one molecule of p97.	Iron	100-104	melanotransferrin	Homo sapiens	16-19
7556058-3	1995	The presence of p97 doubled the iron uptake, which could be explained by the binding of one atom of iron to one molecule of p97.	Iron	100-104	melanotransferrin	Homo sapiens	124-127
7556058-4	1995	The internalization of iron was shown to be temperature sensitive and saturated at a media iron concentration of 2.5 micrograms/ml with a Vmax of 0.1 pmol Fe/10(6) cell/min and a Km of 2.58 microM for p97.	Iron	23-27	melanotransferrin	Homo sapiens	201-204
18618445-2	1994	Recombinant human melano-transferrin (p97) was expressed linked to the outer surface of CHO cells by a glycosyl-phosphatidylinositol (GPI) membrane anchor.	Glycosylphosphatidylinositols	103-132	melanotransferrin	Homo sapiens	18-36
7615630-7	1995	cDNA cloning of p97 shows that it is a unique protein containing 23 cysteine residues.	Cysteine	68-76	melanotransferrin	Homo sapiens	16-19
7615630-8	1995	Recombinant p97 binds zinc and a bound metal ion is required for the nuclear envelope binding activity of the protein.	Metals	39-44	melanotransferrin	Homo sapiens	12-15
7876270-3	1995	GM-CSF stimulation of three different cell lines induced tyrosine phosphorylation of p97 as well as a number of other phosphotyrosylproteins.	Tyrosine	57-65	melanotransferrin	Homo sapiens	85-88
18618445-2	1994	Recombinant human melano-transferrin (p97) was expressed linked to the outer surface of CHO cells by a glycosyl-phosphatidylinositol (GPI) membrane anchor.	Glycosylphosphatidylinositols	103-132	melanotransferrin	Homo sapiens	38-41
18618445-2	1994	Recombinant human melano-transferrin (p97) was expressed linked to the outer surface of CHO cells by a glycosyl-phosphatidylinositol (GPI) membrane anchor.	Glycosylphosphatidylinositols	134-137	melanotransferrin	Homo sapiens	18-36
18618445-2	1994	Recombinant human melano-transferrin (p97) was expressed linked to the outer surface of CHO cells by a glycosyl-phosphatidylinositol (GPI) membrane anchor.	Glycosylphosphatidylinositols	134-137	melanotransferrin	Homo sapiens	38-41
8300636-4	1994	In this study, sensitivity to bacterial phosphatidylinositol-specific phospholipase C, biosynthetic labeling with [3H]ethanolamine, and partitioning in Triton X-114 are used to establish that p97 is expressed at the cell surface as a glycosylphosphatidylinositol-anchored protein.	Phosphatidylinositols	40-60	melanotransferrin	Homo sapiens	192-195
8090582-3	1994	We suggest that the production of p97 by neoplastic cells of atypical adenomas and differentiated thyroid carcinomas could result in a greater availability of iron for tumor cell DNA synthesis.	Iron	159-163	melanotransferrin	Homo sapiens	34-37
7762431-12	1994	These mutations involve the iron binding ligands and have been designed to introduce some of the changes found in the C-lobe of melanotransferrin into LfN.	Iron	28-32	melanotransferrin	Homo sapiens	128-145
8300636-4	1994	In this study, sensitivity to bacterial phosphatidylinositol-specific phospholipase C, biosynthetic labeling with [3H]ethanolamine, and partitioning in Triton X-114 are used to establish that p97 is expressed at the cell surface as a glycosylphosphatidylinositol-anchored protein.	Tritium	115-117	melanotransferrin	Homo sapiens	192-195
8300636-4	1994	In this study, sensitivity to bacterial phosphatidylinositol-specific phospholipase C, biosynthetic labeling with [3H]ethanolamine, and partitioning in Triton X-114 are used to establish that p97 is expressed at the cell surface as a glycosylphosphatidylinositol-anchored protein.	Ethanolamine	118-130	melanotransferrin	Homo sapiens	192-195
8300636-4	1994	In this study, sensitivity to bacterial phosphatidylinositol-specific phospholipase C, biosynthetic labeling with [3H]ethanolamine, and partitioning in Triton X-114 are used to establish that p97 is expressed at the cell surface as a glycosylphosphatidylinositol-anchored protein.	Nonidet P-40	152-164	melanotransferrin	Homo sapiens	192-195
8300636-4	1994	In this study, sensitivity to bacterial phosphatidylinositol-specific phospholipase C, biosynthetic labeling with [3H]ethanolamine, and partitioning in Triton X-114 are used to establish that p97 is expressed at the cell surface as a glycosylphosphatidylinositol-anchored protein.	Glycosylphosphatidylinositols	234-262	melanotransferrin	Homo sapiens	192-195
1544447-0	1992	Human melanotransferrin (p97) has only one functional iron-binding site.	Iron	54-58	melanotransferrin	Homo sapiens	6-23
1385430-4	1992	To address the possibility that p97 may represent a tyrosine kinase involved in multiple signal transduction pathways, we tested the capacity of this protein to bind a tyrosine kinase substrate or ATP.	Adenosine Triphosphate	197-200	melanotransferrin	Homo sapiens	32-35
1633859-0	1992	A molecular model for the tumour-associated antigen, p97, suggests a Zn-binding function.	Zinc	69-71	melanotransferrin	Homo sapiens	53-56
1633859-3	1992	The most significant amino acid substitutions in p97 are almost exclusively limited to only two regions; the C-lobe iron-binding cleft and the interlobe contact region.	Iron	116-120	melanotransferrin	Homo sapiens	49-52
1633859-5	1992	Thus, p97 may have a Zn-binding potential, unique amongst the transferrin superfamily.	Zinc	21-23	melanotransferrin	Homo sapiens	6-9
8314900-0	1993	Glycosyl phosphatidylinositol membrane anchoring of melanotransferrin (p97): apical compartmentalization in intestinal epithelial cells.	Glycosylphosphatidylinositols	0-29	melanotransferrin	Homo sapiens	52-69
8314900-0	1993	Glycosyl phosphatidylinositol membrane anchoring of melanotransferrin (p97): apical compartmentalization in intestinal epithelial cells.	Glycosylphosphatidylinositols	0-29	melanotransferrin	Homo sapiens	71-74
8314900-5	1993	Kinetic studies in melanoma cells have suggested that p97 plays a role in iron metabolism.	Iron	74-78	melanotransferrin	Homo sapiens	54-57
8314900-9	1993	p97 was shown to be anchored to the membrane through a glycosyl phosphatidylinositol moiety by treatment with phophatidylinositol-specific phospholipase C (PI-PLC) and labeling with [14C]ethanolamine.	Glycosylphosphatidylinositols	55-84	melanotransferrin	Homo sapiens	0-3
8314900-9	1993	p97 was shown to be anchored to the membrane through a glycosyl phosphatidylinositol moiety by treatment with phophatidylinositol-specific phospholipase C (PI-PLC) and labeling with [14C]ethanolamine.	Carbon-14	183-186	melanotransferrin	Homo sapiens	0-3
8314900-9	1993	p97 was shown to be anchored to the membrane through a glycosyl phosphatidylinositol moiety by treatment with phophatidylinositol-specific phospholipase C (PI-PLC) and labeling with [14C]ethanolamine.	Ethanolamine	187-199	melanotransferrin	Homo sapiens	0-3
8314900-10	1993	These observations provide a basis for the elucidation of the physiological role of p97 in iron metabolism and its possible role in cell proliferation and malignant cell transformation.	Iron	91-95	melanotransferrin	Homo sapiens	84-87
1544447-0	1992	Human melanotransferrin (p97) has only one functional iron-binding site.	Iron	54-58	melanotransferrin	Homo sapiens	25-28
1544447-1	1992	The iron-binding properties of melanotransferrin, the tumour-associated antigen also known as p97, have been investigated by UV/visible and fluorescence spectroscopy, amino acid sequence comparison, and modelling.	Iron	4-8	melanotransferrin	Homo sapiens	31-48
1544447-1	1992	The iron-binding properties of melanotransferrin, the tumour-associated antigen also known as p97, have been investigated by UV/visible and fluorescence spectroscopy, amino acid sequence comparison, and modelling.	Iron	4-8	melanotransferrin	Homo sapiens	94-97
1544447-2	1992	These show that, in contrast to other transferrins, melanotransferrin binds only one Fe3+ ion per molecule.	ferric sulfate	85-89	melanotransferrin	Homo sapiens	52-69
34779558-0	2022	High salt activates p97 to reduce host antiviral immunity by restricting Viperin induction.	Salts	5-9	melanotransferrin	Homo sapiens	20-23
1543713-2	1992	Exposure of melanoma cells to DFO increased membrane non-Tf-bound Fe uptake (putative melanotransferrin Fe-binding sites), suggesting upregulation of the membrane Fe-binding component.	Deferoxamine	30-33	melanotransferrin	Homo sapiens	86-103
1543713-2	1992	Exposure of melanoma cells to DFO increased membrane non-Tf-bound Fe uptake (putative melanotransferrin Fe-binding sites), suggesting upregulation of the membrane Fe-binding component.	Iron	66-68	melanotransferrin	Homo sapiens	86-103
1543713-2	1992	Exposure of melanoma cells to DFO increased membrane non-Tf-bound Fe uptake (putative melanotransferrin Fe-binding sites), suggesting upregulation of the membrane Fe-binding component.	Iron	104-106	melanotransferrin	Homo sapiens	86-103
1543713-2	1992	Exposure of melanoma cells to DFO increased membrane non-Tf-bound Fe uptake (putative melanotransferrin Fe-binding sites), suggesting upregulation of the membrane Fe-binding component.	Iron	104-106	melanotransferrin	Homo sapiens	86-103
2049409-6	1991	The monoclonal antibody, 96.5, specific for melanotransferrin did not alter total Fe uptake but slightly increased the proportion of Fe internalised, possibly due to the modulation of the antigen by the antibody.	Iron	133-135	melanotransferrin	Homo sapiens	44-61
2001412-1	1991	The role of the transferrin homologue, melanotransferrin (p97), in iron metabolism has been studied using the human melanoma cell line, SK-MEL-28, which expresses this antigen in high concentrations.	Iron	67-71	melanotransferrin	Homo sapiens	39-56
2001412-1	1991	The role of the transferrin homologue, melanotransferrin (p97), in iron metabolism has been studied using the human melanoma cell line, SK-MEL-28, which expresses this antigen in high concentrations.	Iron	67-71	melanotransferrin	Homo sapiens	58-61
2001412-8	1991	A membrane-bound, iron-binding component with properties consistent with melanotransferrin was observed.	Iron	18-22	melanotransferrin	Homo sapiens	73-90
2364114-1	1990	The role of the transferrin homologue, melanotransferrin (p97), in iron metabolism has been studied using the human melanoma cell line, SK-MEL-28, which expresses this antigen in high concentrations.	Iron	67-71	melanotransferrin	Homo sapiens	39-56
2364114-1	1990	The role of the transferrin homologue, melanotransferrin (p97), in iron metabolism has been studied using the human melanoma cell line, SK-MEL-28, which expresses this antigen in high concentrations.	Iron	67-71	melanotransferrin	Homo sapiens	58-61
2364114-10	1990	340,000 per cell (assuming 2 atoms of iron per site) and it is suggested that this binding component may be melanotransferrin.	Iron	38-42	melanotransferrin	Homo sapiens	108-125
34779558-4	2022	Further studies reveal that high salt stimulates the acetylation at Lys663 of p97, which promotes the recruitment of ubiquitinated proteins for proteasome-dependent degradation.	Salts	33-37	melanotransferrin	Homo sapiens	78-81
34149342-2	2021	Our previous studies demonstrated that that a soluble form of melanotransferrin (MTf; Uniprot P08582; also known as p97, MFI2, and CD228), a mammalian iron-transport protein, is an effective carrier for delivery of drug conjugates across the BBB into the brain and was the first BBB targeting delivery system to demonstrate therapeutic efficacy within the brain.	Iron	151-155	melanotransferrin	Homo sapiens	62-79
34520757-4	2021	Here, we present cryo-EM structural analyses of four disease mutants p97R155H, p97R191Q, p97A232E, p97D592N, as well as p97E470D, implicated in resistance to the drug CB-5083, a potent p97 inhibitor.	CB-5083	167-174	melanotransferrin	Homo sapiens	185-188
34405853-0	2021	Conserved L464 in p97 D1-D2 linker is critical for p97 cofactor regulated ATPase activity.	3'-Acetoxyacetophenone	10-14	melanotransferrin	Homo sapiens	51-54
34405853-4	2021	The conserved amino acid leucine 464 (L464) is critical for regulating D1 and D2 ATPase activity by p97 cofactors p37, p47, and Npl4-Ufd1 (NU).	Leucine	25-32	melanotransferrin	Homo sapiens	100-103
34405853-7	2021	NU inhibited D1 ATPase activities of WT and mutant ND1L proteins, but activated D2 ATPase activity of full-length p97.	nu	0-2	melanotransferrin	Homo sapiens	114-117
34149342-2	2021	Our previous studies demonstrated that that a soluble form of melanotransferrin (MTf; Uniprot P08582; also known as p97, MFI2, and CD228), a mammalian iron-transport protein, is an effective carrier for delivery of drug conjugates across the BBB into the brain and was the first BBB targeting delivery system to demonstrate therapeutic efficacy within the brain.	Iron	151-155	melanotransferrin	Homo sapiens	116-119
34149342-2	2021	Our previous studies demonstrated that that a soluble form of melanotransferrin (MTf; Uniprot P08582; also known as p97, MFI2, and CD228), a mammalian iron-transport protein, is an effective carrier for delivery of drug conjugates across the BBB into the brain and was the first BBB targeting delivery system to demonstrate therapeutic efficacy within the brain.	Iron	151-155	melanotransferrin	Homo sapiens	131-136
35552390-5	2022	These findings support the model that p97 utilizes a "hand-over-hand" mechanism in which two residues of the substrate are translocated for hydrolysis of two ATPs, one in each of the two p97 AAA ATPase rings.	Adenosine Triphosphate	158-162	melanotransferrin	Homo sapiens	38-41
35552390-5	2022	These findings support the model that p97 utilizes a "hand-over-hand" mechanism in which two residues of the substrate are translocated for hydrolysis of two ATPs, one in each of the two p97 AAA ATPase rings.	Adenosine Triphosphate	158-162	melanotransferrin	Homo sapiens	187-190
35405035-8	2022	Functionally, inhibition of p97 directly promoted accumulation of polyubiquitinated membrane-associated proteins, excessive ROS levels, and sickling in response to hypoxia.	Reactive Oxygen Species	124-127	melanotransferrin	Homo sapiens	28-31
35405035-9	2022	Overall, we revealed that p97 dysfunction underlies impaired UPS and contributes to oxidative stress in sRBCs.	srbcs	104-109	melanotransferrin	Homo sapiens	26-29
35256959-5	2022	We report herein a new type of TCIs (i.e., FL-18) that showed proteome-wide selectivity towards p97.	Fluorides	43-46	melanotransferrin	Homo sapiens	96-99
35247768-3	2022	Here we report the Cryo-EM structure of full-length human p97 dodecamer in 3.0 A resolution, the structure was captured in ADP-bound form but only D1 ATPase sites were well occupied by nucleotide and D2 sites are empty, furthermore, 12 non-ATP-competitive inhibitors of NMS-873 bound in the interface between each p97 monomer.	Adenosine Diphosphate	123-126	melanotransferrin	Homo sapiens	58-61
35247768-3	2022	Here we report the Cryo-EM structure of full-length human p97 dodecamer in 3.0 A resolution, the structure was captured in ADP-bound form but only D1 ATPase sites were well occupied by nucleotide and D2 sites are empty, furthermore, 12 non-ATP-competitive inhibitors of NMS-873 bound in the interface between each p97 monomer.	Adenosine Triphosphate	240-243	melanotransferrin	Homo sapiens	58-61
35456598-1	2022	Adenosine triphosphate (ATP)-competitive p97 inhibitor CB-5339, the successor of CB-5083, is being evaluated in Phase 1 clinical trials for anti-cancer therapy.	Adenosine	0-9	melanotransferrin	Homo sapiens	41-44
35456598-1	2022	Adenosine triphosphate (ATP)-competitive p97 inhibitor CB-5339, the successor of CB-5083, is being evaluated in Phase 1 clinical trials for anti-cancer therapy.	Adenosine Triphosphate	24-27	melanotransferrin	Homo sapiens	41-44
35456598-1	2022	Adenosine triphosphate (ATP)-competitive p97 inhibitor CB-5339, the successor of CB-5083, is being evaluated in Phase 1 clinical trials for anti-cancer therapy.	p97-IN-1	55-62	melanotransferrin	Homo sapiens	41-44
35456598-1	2022	Adenosine triphosphate (ATP)-competitive p97 inhibitor CB-5339, the successor of CB-5083, is being evaluated in Phase 1 clinical trials for anti-cancer therapy.	CB-5083	81-88	melanotransferrin	Homo sapiens	41-44
35068071-7	2022	Under acidic tumor microenvironment (TME) and 808 nm laser irradiation, BTZ is released and ROS is generated by Ce6 to destroy the "bounce-back" response pathway proteins, such as DDI2 and p97, which can effectively inhibit proteasomes and increase apoptosis.	Bortezomib	72-75	melanotransferrin	Homo sapiens	189-192
35068071-7	2022	Under acidic tumor microenvironment (TME) and 808 nm laser irradiation, BTZ is released and ROS is generated by Ce6 to destroy the "bounce-back" response pathway proteins, such as DDI2 and p97, which can effectively inhibit proteasomes and increase apoptosis.	ros	92-95	melanotransferrin	Homo sapiens	189-192
35256959-6	2022	Equipped with a Michael acceptor and a basic imidazole, FL-18 showed potent inhibition towards U87MG tumor cells, and in proteome-wide profiling, selectively modified endogenous p97 as confirmed by in situ fluorescence scanning, label-free quantitative proteomics and functional validations.	imidazole	45-54	melanotransferrin	Homo sapiens	178-181
35256959-6	2022	Equipped with a Michael acceptor and a basic imidazole, FL-18 showed potent inhibition towards U87MG tumor cells, and in proteome-wide profiling, selectively modified endogenous p97 as confirmed by in situ fluorescence scanning, label-free quantitative proteomics and functional validations.	fl-18	56-61	melanotransferrin	Homo sapiens	178-181
35256959-7	2022	FL-18 selectively modified cysteine residues located within the D2 ATP site of p97.	Fluorides	0-2	melanotransferrin	Homo sapiens	79-82
35256959-7	2022	FL-18 selectively modified cysteine residues located within the D2 ATP site of p97.	Cysteine	27-35	melanotransferrin	Homo sapiens	79-82
35256959-7	2022	FL-18 selectively modified cysteine residues located within the D2 ATP site of p97.	Adenosine Triphosphate	67-70	melanotransferrin	Homo sapiens	79-82
35256959-8	2022	This covalent labeling of cysteine residue in p97 was verified by LC-MS/MS-based site-mapping and site-directed mutagenesis.	Cysteine	26-34	melanotransferrin	Homo sapiens	46-49
35256959-10	2022	Collectively, FL-18 is the first known small-molecule TCI capable of covalent engagement of p97 with proteome-wide selectivity, thus providing a promising scaffold for cancer therapy.	fl-18	14-19	melanotransferrin	Homo sapiens	92-95
2419904-8	1986	Conservation of disulfide bridges and of amino acids thought to compose the iron binding pockets suggests that p97 is also related to transferrin in tertiary structure and function.	Disulfides	16-25	melanotransferrin	Homo sapiens	111-114
35013556-6	2022	Small-molecule p97-complex inhibitors, including a metabolite of the clinically used drug disulfiram (CuET), prolonged PARP1 trapping and enhanced PARP inhibitor-induced cytotoxicity in homologous recombination-defective tumour cells and patient-derived tumour organoids.	Disulfiram	90-100	melanotransferrin	Homo sapiens	15-18
35013556-6	2022	Small-molecule p97-complex inhibitors, including a metabolite of the clinically used drug disulfiram (CuET), prolonged PARP1 trapping and enhanced PARP inhibitor-induced cytotoxicity in homologous recombination-defective tumour cells and patient-derived tumour organoids.	ethylglyoxal bis(thiosemicarbazonato)copper(II)	102-106	melanotransferrin	Homo sapiens	15-18
3010712-1	1986	Since the p97 antigen, a membrane-associated iron-binding protein, has extensive amino acid sequence with homology with transferrin, is functionally related to the transferrin receptor, and has been previously mapped to chromosome 3, we have performed additional studies for regional mapping of the gene expressing p97 antigen.	Iron	45-49	melanotransferrin	Homo sapiens	10-13
3129542-2	1988	rIFN-alpha-A at optimal concentrations of 50 and 500 U/ml caused significant (p less than 0.05 and p less than 0.01, respectively) increases in expression of p97 on the melanoma cell line Hs 294t following a 48-h incubation.	rifn-alpha-a	0-12	melanotransferrin	Homo sapiens	158-161
3754536-5	1986	p97 belongs to a superfamily of iron-binding proteins that have amino acid homology; other members of this family include transferrin (TF), lactotransferrin, and ovotransferrin.	Iron	32-36	melanotransferrin	Homo sapiens	0-3
2419904-8	1986	Conservation of disulfide bridges and of amino acids thought to compose the iron binding pockets suggests that p97 is also related to transferrin in tertiary structure and function.	Iron	76-80	melanotransferrin	Homo sapiens	111-114
6326658-3	1984	The gene for TF therefore maps to the same region as the gene for transferrin receptor (TFR) thereby defining an iron transport region on 3q2 to which the transferrin-related tumor associated antigen p97 may also belong.	Iron	113-117	melanotransferrin	Homo sapiens	200-203
6699726-1	1984	Two different murine monoclonal antibody Fab fragments specific for p97, a melanoma-associated antigen, were labeled with I-131 at high activity levels without excessive chemical damage.	Iodine-131	122-127	melanotransferrin	Homo sapiens	68-71
3986780-0	1985	Pharmacokinetics of 111In-labeled anti-p97 monoclonal antibody in patients with metastatic malignant melanoma.	Indium-111	20-25	melanotransferrin	Homo sapiens	39-42
6196380-0	1983	Localization of 131I-labeled p97-specific Fab fragments in human melanoma as a basis for radiotherapy.	Iodine-131	16-20	melanotransferrin	Homo sapiens	29-32
6196380-1	1983	33 patients with advanced malignant melanoma were studied after intravenous administration of 131I-labeled Fab fragments specific for p97, an oncofetal glycoprotein of human melanoma.	Iodine-131	94-98	melanotransferrin	Homo sapiens	134-137
6196380-8	1983	Also, imaging studies of the bio-distribution of 131I-labeled anti-p97 Fab in patients selected for high p97 tumor concentration showed avid tumor uptake and more prolonged retention of labeled Fab in tumor than in normal tissues.	Iodine-131	49-53	melanotransferrin	Homo sapiens	67-70
6196380-8	1983	Also, imaging studies of the bio-distribution of 131I-labeled anti-p97 Fab in patients selected for high p97 tumor concentration showed avid tumor uptake and more prolonged retention of labeled Fab in tumor than in normal tissues.	Iodine-131	49-53	melanotransferrin	Homo sapiens	105-108
6196380-18	1983	In two of these patients it was possible to successfully reinfuse after immunity had developed with 131I-(anti-p97) Fab of a different isotype (IgG2a).	Iodine-131	100-104	melanotransferrin	Homo sapiens	111-114
6308476-3	1983	Recent genetic analysis has shown that structural genes for the transferrin receptor, probably transferrin itself and for p97, a melanoma-associated antigen that exhibits primary sequence homology with transferrin and that can bind ferric iron, each map in man to chromosome 3 (refs 9-12).	ferric sulfate	232-243	melanotransferrin	Homo sapiens	122-125
33965973-5	2021	Melanotransferrin is typically overexpressed in melanoma cells compared to other cell types - including cancer cells - and is efficiently sorted and secreted with nanovesicles, or so-called exosomes, due to its membrane-anchoring by a glycosylphosphatidylinositol.	Glycosylphosphatidylinositols	235-263	melanotransferrin	Homo sapiens	0-17
6166674-11	1981	SDS-PAGE under nonreducing conditions indicated that p97 is monomeric, probably with intrachain disulfide bonds.	Sodium Dodecyl Sulfate	0-3	melanotransferrin	Homo sapiens	53-56
6166674-11	1981	SDS-PAGE under nonreducing conditions indicated that p97 is monomeric, probably with intrachain disulfide bonds.	Disulfides	96-105	melanotransferrin	Homo sapiens	53-56
6166674-12	1981	Cell-surface labeling of sialic acid residues and neuraminidase digestion showed that p97 is a sialoglycoprotein.	N-Acetylneuraminic Acid	25-36	melanotransferrin	Homo sapiens	86-89
6843660-2	1983	Amino acid sequence and iron binding studies have shown that p97 is structurally and functionally related to transferrin.	Iron	24-28	melanotransferrin	Homo sapiens	61-64
7141740-3	1982	The presence of 10 mM ammonium chloride significantly increased the efficiency of the immunotoxin, tumor cells expressing high levels of p97 being killed at immunotoxin concentrations as low as 10(-10) M.	Ammonium Chloride	22-39	melanotransferrin	Homo sapiens	137-140
33965973-8	2021	Melanotransferrin was detected using a low number of exosomes purified from melanoma cell line cultures, and melanotransferrin detection was abolished by phosphatidylinositol-specific phospholipase C treatment.	Phosphatidylinositols	154-174	melanotransferrin	Homo sapiens	109-126
33965973-9	2021	This exosomal melanotransferrin ELISA was able to discriminate an equal number of assayed exosomes purified from two different melanoma cell lines (A-375 vs. SK-MEL-28).	sk-mel	158-164	melanotransferrin	Homo sapiens	14-31
33421110-5	2021	Using PC9-KI cells, we screened 1,280 chemical compounds from the Library of Pharmacologically Active Compounds (LOPAC) and identified microtubule polymerization inhibitors and thapsigargin as PD-L1 upregulators and a p97 inhibitor as a PD-L1 downregulator.	Thapsigargin	177-189	melanotransferrin	Homo sapiens	218-221
33712450-8	2021	Loss of p97-UBXN1 results in increased Huntingtin polyQ inclusion bodies both in mammalian cells as well as in a C.elegans model of Huntington"s Disease.	polyglutamine	50-55	melanotransferrin	Homo sapiens	8-11
32551674-4	2020	The CuET@HA NPs could selectively deliver into cancer cells, and release the active component of CuET in response to both endo/lysosome acidic pH and intracellular abundant GSH, which induces strong cytotoxicity toward cancer cells over normal cells taking advantage of the p97 pathway interference mechanism.	Glutathione	173-176	melanotransferrin	Homo sapiens	274-277
33436675-1	2021	Melanotransferrin (MTf) is an iron-binding member of the transferrin superfamily that can be membrane-anchored or secreted in serum.	Iron	30-34	melanotransferrin	Homo sapiens	0-17
33436675-1	2021	Melanotransferrin (MTf) is an iron-binding member of the transferrin superfamily that can be membrane-anchored or secreted in serum.	Iron	30-34	melanotransferrin	Homo sapiens	19-22
32857889-2	2020	Large changes to the orientation of its N-terminal domains (NTDs), corresponding to NTD-down (p97-ADP) or NTD-up (p97-ATP), accompany ATP hydrolysis.	Adenosine Diphosphate	98-101	melanotransferrin	Homo sapiens	94-97
32857889-2	2020	Large changes to the orientation of its N-terminal domains (NTDs), corresponding to NTD-down (p97-ADP) or NTD-up (p97-ATP), accompany ATP hydrolysis.	Adenosine Triphosphate	118-121	melanotransferrin	Homo sapiens	114-117
32857889-2	2020	Large changes to the orientation of its N-terminal domains (NTDs), corresponding to NTD-down (p97-ADP) or NTD-up (p97-ATP), accompany ATP hydrolysis.	Adenosine Triphosphate	134-137	melanotransferrin	Homo sapiens	94-97
32857889-2	2020	Large changes to the orientation of its N-terminal domains (NTDs), corresponding to NTD-down (p97-ADP) or NTD-up (p97-ATP), accompany ATP hydrolysis.	Adenosine Triphosphate	134-137	melanotransferrin	Homo sapiens	114-117
32857889-3	2020	The NTDs in a series of p97 disease mutants interconvert rapidly between up and down conformations when p97 is in the ADP-bound state.	Adenosine Diphosphate	118-121	melanotransferrin	Homo sapiens	24-27
32857889-3	2020	The NTDs in a series of p97 disease mutants interconvert rapidly between up and down conformations when p97 is in the ADP-bound state.	Adenosine Diphosphate	118-121	melanotransferrin	Homo sapiens	104-107
33746574-1	2021	Melanotransferrin (CD228), firstly reported as a melanoma-associated antigen, is a membrane-bound glycoprotein of an iron-binding transferrin homolog.	Iron	117-121	melanotransferrin	Homo sapiens	0-17
33746574-1	2021	Melanotransferrin (CD228), firstly reported as a melanoma-associated antigen, is a membrane-bound glycoprotein of an iron-binding transferrin homolog.	Iron	117-121	melanotransferrin	Homo sapiens	19-24
33746574-5	2021	Surprisingly, siRNA-mediated CD228 knockdown increased the expression of the transcription factor DLX5 and enhanced osteogenesis of hBM-MSC evidenced by an increased expression of the runt-related transcription factor 2 (RUNX2), osterix (Osx), and osteocalcin (OC), as well as higher alkaline phosphatase (ALP) activity and extracellular calcium deposition.	Calcium	338-345	melanotransferrin	Homo sapiens	29-34
33746574-6	2021	Interestingly, hBM-MSC transfected with CD228 siRNA also showed an increase in intracellular lipid level during adipogenesis, indicated by oil red O staining of differentiated adipocytes.	oil red O	139-148	melanotransferrin	Homo sapiens	40-45
33436675-0	2021	Complex of human Melanotransferrin and SC57.32 Fab fragment reveals novel interdomain arrangement with ferric N-lobe and open C-lobe.	ferric n	103-111	melanotransferrin	Homo sapiens	17-34
31678554-0	2020	Knockdown of lncRNA MFI2-AS1 inhibits lipopolysaccharide-induced osteoarthritis progression by miR-130a-3p/TCF4.	mir-130a-3p	95-106	melanotransferrin	Homo sapiens	20-24
32655822-0	2020	CB-5083, an inhibitor of P97, suppresses osteosarcoma growth and stem cell properties by altering protein homeostasis.	CB-5083	0-7	melanotransferrin	Homo sapiens	25-28
32655822-2	2020	Here, we assessed the antitumor ability of CB-5083, an oral inhibitor of P97, in osteosarcoma.	CB-5083	43-50	melanotransferrin	Homo sapiens	73-76
32115827-1	2020	Commonly used methods to assess crystallinity, micro-/mesoporosity, Bronsted acid site density and distribution (in micro-  vs. mesopores), and catalytic activity suggest nearly invariant structure and function for aluminosilicate zeolite MFI 2D nanosheets before and after superheated steam treatment.	aluminosilicate zeolite	215-238	melanotransferrin	Homo sapiens	239-244
31701538-0	2020	Crystal structure of the catalytic D2 domain of the AAA + ATPase p97 reveals a putative helical split-washer-type mechanism for substrate unfolding.	N-(3,3-diphenylpropyl)-N'-(1-(3,4-bis(butoxyphenyl))ethyl)propylenediamine	52-55	melanotransferrin	Homo sapiens	65-68
31701538-1	2020	Several pathologies have been associated with the AAA + ATPase p97, an enzyme essential to protein homeostasis.	N-(3,3-diphenylpropyl)-N'-(1-(3,4-bis(butoxyphenyl))ethyl)propylenediamine	50-53	melanotransferrin	Homo sapiens	63-66
31701538-4	2020	High-resolution structural models of its catalytic D2 domain, however, have proved elusive, as has the mechanism by which p97 converts the energy from ATP hydrolysis into mechanical force to unfold protein substrates.	Adenosine Triphosphate	151-154	melanotransferrin	Homo sapiens	122-125
32423265-0	2020	Thrombospondin-1 counteracts the p97 inhibitor CB-5083 in colon carcinoma cells.	CB-5083	47-54	melanotransferrin	Homo sapiens	33-36
32423265-2	2020	CB-5083 is a first-in-class, potent and selective ATP-competitive p97 inhibitor that induces proteotoxic stress in cancer cells.	CB-5083	0-7	melanotransferrin	Homo sapiens	66-69
32423265-2	2020	CB-5083 is a first-in-class, potent and selective ATP-competitive p97 inhibitor that induces proteotoxic stress in cancer cells.	Adenosine Triphosphate	50-53	melanotransferrin	Homo sapiens	66-69
32423265-7	2020	Suppression of THBS1 caused an increase of CB-5083-induced sub-G1 population and caspase 3/7 activity suggesting that its function is linked to the survival of cancer cells in response to p97 inhibition.	CB-5083	43-50	melanotransferrin	Homo sapiens	188-191
32728610-0	2020	A Cereblon Modulator CC-885 Induces CRBN- and p97-Dependent PLK1 Degradation and Synergizes with Volasertib to Suppress Lung Cancer.	CC-885	21-27	melanotransferrin	Homo sapiens	46-49
32728610-8	2020	Mechanistically, CC-885 selectively promotes CRBN- and p97-dependent PLK1 ubiquitination and degradation, thereby enhancing the sensitivity of NSCLC to volasertib.	CC-885	17-23	melanotransferrin	Homo sapiens	55-58
31678554-12	2020	Moreover, knockdown of MFI2-AS1 alleviated LPS-induced cell injury in C28/I2 cells by mediating miR-130a-3p and TCF4.	mir-130a-3p	96-107	melanotransferrin	Homo sapiens	23-27
33855508-0	2019	Molecular Dynamics Simulations of p97 Including Covalent, Allosteric and ATP-competitive Inhibitors.	Adenosine Triphosphate	73-76	melanotransferrin	Homo sapiens	34-37
31298339-13	2019	The rescue experiments reveal that miR-485-5p inhibition reverses the suppressive impacts of MFI2-AS1 silencing on the growth, migration, and invasive abilities of glioma cells.	mir-485-5p	35-45	melanotransferrin	Homo sapiens	93-97
30954557-6	2019	Induction of ER stress and apoptosis by the p97 inhibitor CB-5083 was strongly enhanced in combination with the PI3Kalpha inhibitor BYL-719 or the HDAC inhibitor panobinostat suggesting potential therapeutic strategies to circumvent IXA resistance in MM.	CB-5083	58-65	melanotransferrin	Homo sapiens	44-47
30954557-6	2019	Induction of ER stress and apoptosis by the p97 inhibitor CB-5083 was strongly enhanced in combination with the PI3Kalpha inhibitor BYL-719 or the HDAC inhibitor panobinostat suggesting potential therapeutic strategies to circumvent IXA resistance in MM.	Panobinostat	162-174	melanotransferrin	Homo sapiens	44-47
30906244-2	2019	Serum melanotransferrin (MTf), a transferrin homolog capable of reversibly binding iron, has been proposed as a biochemical marker of AD.	Iron	83-87	melanotransferrin	Homo sapiens	6-23
30906244-2	2019	Serum melanotransferrin (MTf), a transferrin homolog capable of reversibly binding iron, has been proposed as a biochemical marker of AD.	Iron	83-87	melanotransferrin	Homo sapiens	25-28
30906244-3	2019	MTf has also been shown to be elevated in iron-rich reactive microglia near amyloid plaques in AD.	Iron	42-46	melanotransferrin	Homo sapiens	0-3
31939153-1	2019	p97 belongs to the functional diverse superfamily of AAA+ (ATPases Associated with diverse cellular Activities) ATPases and is characterized by an N-terminal regulatory domain and two stacked hexameric ATPase domains forming a central protein conducting channel.	Nitrogen	147-148	melanotransferrin	Homo sapiens	0-3
30591537-2	2019	This concept was nearly realized recently when a potent p97 inhibitor, 1-[4-(benzylamino)-5H,7H,8H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide (CB-5083), was developed and demonstrated broad antitumor activity in various tumor models.	CB-5083	162-169	melanotransferrin	Homo sapiens	56-59
30591537-3	2019	CB-5083 functions as a competitive inhibitor that binds selectively to the ATP-binding site of the D2 domain, although both the D1 and D2 ATPase sites of p97 are highly similar.	CB-5083	0-7	melanotransferrin	Homo sapiens	154-157
30591537-6	2019	It provides a structural basis for the specificity of CB-5083 toward the D2 domain, offers an explanation in atomic detail for the mutations that confer resistance to CB-5083, and establishes a foundation for future structure-guided efforts to develop the next generation of p97 inhibitors.	CB-5083	54-61	melanotransferrin	Homo sapiens	275-278
30591537-0	2019	Structural Basis of p97 Inhibition by the Site-Selective Anticancer Compound CB-5083.	CB-5083	77-84	melanotransferrin	Homo sapiens	20-23
30591537-2	2019	This concept was nearly realized recently when a potent p97 inhibitor, 1-[4-(benzylamino)-5H,7H,8H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide (CB-5083), was developed and demonstrated broad antitumor activity in various tumor models.	CB-5083	71-160	melanotransferrin	Homo sapiens	56-59
31939153-3	2019	p97 can use energy derived from ATP hydrolysis to catalyze substrate unfolding and threading through its central channel.	Adenosine Triphosphate	32-35	melanotransferrin	Homo sapiens	0-3
30344098-4	2018	Reconstitution with purified components revealed direct interaction of the p37 SEP domain with I3 without the need for ubiquitination, and ATP-driven pulling of I3 into the central channel of the p97 hexamer, which triggers dissociation of I3 and SDS22.	Adenosine Triphosphate	139-142	melanotransferrin	Homo sapiens	196-199
30619121-6	2018	Non-synonymous mutations in the LCR-resident TPA (12-O-tetradecanoylphorbol 13-acetate)-response elements (TRE) had significantly decreased p97 promoter activation.	Tetradecanoylphorbol Acetate	45-48	melanotransferrin	Homo sapiens	140-143
30619121-6	2018	Non-synonymous mutations in the LCR-resident TPA (12-O-tetradecanoylphorbol 13-acetate)-response elements (TRE) had significantly decreased p97 promoter activation.	Tetradecanoylphorbol Acetate	50-86	melanotransferrin	Homo sapiens	140-143
30381397-2	2018	The ATP-competitive inhibitor CB-5083 and allosteric inhibitor NMS-873 are the most advanced p97 inhibitors described to date.	Adenosine Triphosphate	4-7	melanotransferrin	Homo sapiens	93-96
30381397-2	2018	The ATP-competitive inhibitor CB-5083 and allosteric inhibitor NMS-873 are the most advanced p97 inhibitors described to date.	CB-5083	30-37	melanotransferrin	Homo sapiens	93-96
30344098-4	2018	Reconstitution with purified components revealed direct interaction of the p37 SEP domain with I3 without the need for ubiquitination, and ATP-driven pulling of I3 into the central channel of the p97 hexamer, which triggers dissociation of I3 and SDS22.	sds22	247-252	melanotransferrin	Homo sapiens	196-199
30429948-0	2018	Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97.	phenyl indole	16-29	melanotransferrin	Homo sapiens	60-63
30429948-1	2018	Optimization of the side-chain of a phenyl indole scaffold identified from a high-throughput screening campaign for inhibitors of the AAA+ ATPase p97 is reported.	phenyl indole	36-49	melanotransferrin	Homo sapiens	146-149
30429948-3	2018	Molecular modeling based on a subsequently obtained cryo-EM structure of p97 in complex with a phenyl indole was used to rationalize the potency of these allosteric inhibitors.	phenyl indole	95-108	melanotransferrin	Homo sapiens	73-76
29208956-4	2017	Abrogation of this modification results in a reduced level of CRL4CDT2-dependent Poleta polyubiquitination at lysine 462, a delayed p97-dependent removal of Poleta from replication forks, and significantly enhanced UV-induced mutagenesis even though Poleta focus formation and its efficacy to bypass across cyclobutane pyrimidine dimers after UV irradiation are not affected.	cyclobutane pyrimidine	307-329	melanotransferrin	Homo sapiens	132-135
29271116-3	2018	Here, we characterize the compound MSC1094308 as a reversible, allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B.	MSC1094308	35-45	melanotransferrin	Homo sapiens	151-154
30069488-0	2018	PYR-41 and Thalidomide Impair Dendritic Cell Cross-Presentation by Inhibiting Myddosome Formation and Attenuating the Endosomal Recruitments of p97 and Sec61 via NF-kappaB Inactivation.	4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester	0-6	melanotransferrin	Homo sapiens	144-147
30069488-0	2018	PYR-41 and Thalidomide Impair Dendritic Cell Cross-Presentation by Inhibiting Myddosome Formation and Attenuating the Endosomal Recruitments of p97 and Sec61 via NF-kappaB Inactivation.	Thalidomide	11-22	melanotransferrin	Homo sapiens	144-147
30069488-5	2018	We demonstrated that the inhibition of endosomal recruitment of p97 and Sec61, together with attenuated NF-kappaB activation and Myddosome formation, contributes to PYR-41- and thalidomide-impaired cross-presentation and thereby reverses cross-activation of T cells.	4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester	165-171	melanotransferrin	Homo sapiens	64-67
30069488-5	2018	We demonstrated that the inhibition of endosomal recruitment of p97 and Sec61, together with attenuated NF-kappaB activation and Myddosome formation, contributes to PYR-41- and thalidomide-impaired cross-presentation and thereby reverses cross-activation of T cells.	Thalidomide	177-188	melanotransferrin	Homo sapiens	64-67
30069488-6	2018	These observations suggest that NF-kappaB signaling and p97 and Sec61 molecules are candidates for dealing with the side effects of PYR-41 and thalidomide.	4(4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester	132-138	melanotransferrin	Homo sapiens	56-59
30069488-6	2018	These observations suggest that NF-kappaB signaling and p97 and Sec61 molecules are candidates for dealing with the side effects of PYR-41 and thalidomide.	Thalidomide	143-154	melanotransferrin	Homo sapiens	56-59
29804830-0	2018	ZFAND1 Recruits p97 and the 26S Proteasome to Promote the Clearance of Arsenite-Induced Stress Granules.	arsenite	71-79	melanotransferrin	Homo sapiens	16-19
29804830-5	2018	ZFAND1 interacts with two key factors of protein degradation, the 26S proteasome and the ubiquitin-selective segregase p97, and recruits them to arsenite-induced SGs.	arsenite	145-153	melanotransferrin	Homo sapiens	119-122
28819009-2	2017	p97 acts downstream from ubiquitin signaling events and utilizes the energy from ATP hydrolysis to extract its substrate proteins from cellular structures or multiprotein complexes.	Adenosine Triphosphate	81-84	melanotransferrin	Homo sapiens	0-3
28878026-0	2017	The p97 Inhibitor CB-5083 Is a Unique Disrupter of Protein Homeostasis in Models of Multiple Myeloma.	CB-5083	18-25	melanotransferrin	Homo sapiens	4-7
28878026-1	2017	Inhibition of the AAA ATPase, p97, was recently shown to be a novel method for targeting the ubiquitin proteasome system, and CB-5083, a first-in-class inhibitor of p97, has demonstrated broad antitumor activity in a range of both hematologic and solid tumor models.	CB-5083	126-133	melanotransferrin	Homo sapiens	165-168
28878026-5	2017	CB-5083 has a unique mechanism of action that combines well with PIs, which is likely owing to the p97-dependent retro-translocation of the transcription factor, Nrf1, which transcribes proteasome subunit genes following exposure to a PI.	CB-5083	0-7	melanotransferrin	Homo sapiens	99-102
28878026-5	2017	CB-5083 has a unique mechanism of action that combines well with PIs, which is likely owing to the p97-dependent retro-translocation of the transcription factor, Nrf1, which transcribes proteasome subunit genes following exposure to a PI.	Monothiopyrophosphoric acid	65-68	melanotransferrin	Homo sapiens	99-102
28551638-7	2017	The expression of MTf was shown to be up-regulated by mannose-6-phosphate and that of TFRC by HA.	mannose-6-phosphate	54-73	melanotransferrin	Homo sapiens	18-21
28636814-0	2017	Arsenic Compromises Both p97 and Proteasome Functions.	Arsenic	0-7	melanotransferrin	Homo sapiens	25-28
28636814-6	2017	Interestingly, the loss of p97 activity is due to the increased rate of ATP hydrolysis, which mimics a collection of pathogenic genetic p97 lesions.	Adenosine Triphosphate	72-75	melanotransferrin	Homo sapiens	27-30
28636814-6	2017	Interestingly, the loss of p97 activity is due to the increased rate of ATP hydrolysis, which mimics a collection of pathogenic genetic p97 lesions.	Adenosine Triphosphate	72-75	melanotransferrin	Homo sapiens	136-139
28636814-8	2017	This loss of both p97 and proteasome functions can explain the catastrophic protein quality control issues observed in acute, high level arsenic exposures.	Arsenic	137-144	melanotransferrin	Homo sapiens	18-21
28575658-6	2017	RFWD3 inhibits persistent mitomycin C (MMC)-induced RAD51 and RPA foci by promoting VCP/p97-mediated protein dynamics and subsequent degradation.	Mitomycin	26-37	melanotransferrin	Homo sapiens	88-91
28352916-0	2017	A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site.	Threonine	2-11	melanotransferrin	Homo sapiens	84-87
28575658-6	2017	RFWD3 inhibits persistent mitomycin C (MMC)-induced RAD51 and RPA foci by promoting VCP/p97-mediated protein dynamics and subsequent degradation.	Mitomycin	39-42	melanotransferrin	Homo sapiens	88-91
28352916-2	2017	A computational model based on SAR data and both X-ray and cryo-EM structures of the AAA ATPase p97 was used to analyze the effects of paired threonines at the inhibitor site.	Threonine	142-152	melanotransferrin	Homo sapiens	96-99
27990419-2	2016	With the assistance of a variety of cofactors and adaptor proteins, p97 couples the energy of ATP hydrolysis to conformational changes that are necessary for its function.	Adenosine Triphosphate	94-97	melanotransferrin	Homo sapiens	68-71
28380302-5	2017	Two weeks later, 10 muCi of 131I-labeled melanoma-associated 96.5 monoclonal antibody (targeting p97 antigen) was intravenously injected.	Iodine-131	28-32	melanotransferrin	Homo sapiens	97-100
28274878-0	2017	Crystal structures of the UBX domain of human UBXD7 and its complex with p97 ATPase.	N-[(S)-({[(Benzyloxy)carbonyl]amino}methyl)(Hydroxy)phosphoryl]-N-Methyl-L-Leucinamide	26-29	melanotransferrin	Homo sapiens	73-76
27528392-0	2016	Anti-cancer Antibody Trastuzumab-Melanotransferrin Conjugate (BT2111) for the Treatment of Metastatic HER2+ Breast Cancer Tumors in the Brain: an In-Vivo Study.	bt2111	62-68	melanotransferrin	Homo sapiens	33-50
27528392-1	2016	PURPOSE: The ability of human melanotransferrin (hMTf) to carry a therapeutic concentration of trastuzumab (BTA) in the brain after conjugation (in the form of trastuzumab-melanotransferrin conjugate, BT2111 conjugate) was investigated by measuring the reduction of the number and size of metastatic human HER2+ breast cancer tumors in a preclinical model of brain metastases of breast cancer.	benzotriazole	108-111	melanotransferrin	Homo sapiens	30-47
27528392-1	2016	PURPOSE: The ability of human melanotransferrin (hMTf) to carry a therapeutic concentration of trastuzumab (BTA) in the brain after conjugation (in the form of trastuzumab-melanotransferrin conjugate, BT2111 conjugate) was investigated by measuring the reduction of the number and size of metastatic human HER2+ breast cancer tumors in a preclinical model of brain metastases of breast cancer.	benzotriazole	108-111	melanotransferrin	Homo sapiens	49-53
27404360-4	2016	Syn5 ubiquitination on lysine 270 (K270) in the SNARE domain impairs the interaction between Syn5 and the cognate v-SNARE Bet1 but increases its binding to p47, the adaptor protein of p97.	Lysine	23-29	melanotransferrin	Homo sapiens	184-187
27762274-0	2016	Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.	N-[(S)-({[(Benzyloxy)carbonyl]amino}methyl)(Hydroxy)phosphoryl]-N-Methyl-L-Leucinamide	53-56	melanotransferrin	Homo sapiens	97-100
26768307-0	2016	Enhanced delivery of etoposide across the blood-brain barrier to restrain brain tumor growth using melanotransferrin antibody- and tamoxifen-conjugated solid lipid nanoparticles.	Etoposide	21-30	melanotransferrin	Homo sapiens	99-116
26768307-1	2016	Melanotransferrin antibody (MA) and tamoxifen (TX) were conjugated on etoposide (ETP)-entrapped solid lipid nanoparticles (ETP-SLNs) to target the blood-brain barrier (BBB) and glioblastom multiforme (GBM).	Etoposide	70-79	melanotransferrin	Homo sapiens	0-17
26768307-1	2016	Melanotransferrin antibody (MA) and tamoxifen (TX) were conjugated on etoposide (ETP)-entrapped solid lipid nanoparticles (ETP-SLNs) to target the blood-brain barrier (BBB) and glioblastom multiforme (GBM).	Etoposide	81-84	melanotransferrin	Homo sapiens	0-17
27404360-4	2016	Syn5 ubiquitination on lysine 270 (K270) in the SNARE domain impairs the interaction between Syn5 and the cognate v-SNARE Bet1 but increases its binding to p47, the adaptor protein of p97.	2'-Deoxyadenosine 5'-triphosphate disodium salt	35-39	melanotransferrin	Homo sapiens	184-187
27115850-4	2016	Here, we address this issue by using bioorthogonal azide-alkyne chemistry to attach an smFRET dye pair to site-specifically incorporated unnatural amino acids, allowing us to generate p97 variants reporting on inter- or intradomain structural features.	azide-alkyne	51-63	melanotransferrin	Homo sapiens	184-187
27223265-0	2016	Selective inhibition of p97 by chlorinated analogues of dehydrocurvularin.	dehydrocurvularin	56-73	melanotransferrin	Homo sapiens	24-27
27223265-1	2016	The ATPase p97 is a ubiquitin targeted segregase that uses the energy of ATP binding and hydrolysis to extract ubiquitylated substrates from biological membranes, from other proteins, or from protein complexes to carry out myriad tasks in eukaryotes.	Adenosine Triphosphate	4-7	melanotransferrin	Homo sapiens	11-14
27223265-3	2016	In the present study, we show that dehydrocurvularin (DHC) and its chlorinated variants are covalent inhibitors of p97, interfering with its ATPase activity.	dehydrocurvularin	35-52	melanotransferrin	Homo sapiens	115-118
27223265-3	2016	In the present study, we show that dehydrocurvularin (DHC) and its chlorinated variants are covalent inhibitors of p97, interfering with its ATPase activity.	dehydrocurvularin	54-57	melanotransferrin	Homo sapiens	115-118
27223265-4	2016	Interestingly, cellular studies revealed both DHC and its monochloro analogue interfere with both the proteasome and p97, whereas its dichloro analogue showed p97 specificity.	dehydrocurvularin	46-49	melanotransferrin	Homo sapiens	117-120
27223265-4	2016	Interestingly, cellular studies revealed both DHC and its monochloro analogue interfere with both the proteasome and p97, whereas its dichloro analogue showed p97 specificity.	dichloro	134-142	melanotransferrin	Homo sapiens	159-162
26453804-2	2016	The recognition that Pex1p shares a conserved ATP-binding domain with p97 and NSF led to the discovery of the extended family of AAA+-type ATPases.	Adenosine Triphosphate	46-49	melanotransferrin	Homo sapiens	70-73
26701338-1	2016	Solid lipid nanoparticles (SLNs) comprising complex internal lipids were conjugated with melanotransferrin antibody (MA) to carry anticancer etoposide across the blood-brain barrier (BBB) for managing glioblastoma multiforme (GBM).	Etoposide	141-150	melanotransferrin	Homo sapiens	89-106
26953339-7	2016	However, the position of the N-domain modules relative to the AAA domains in the Msm0858-ADP tertiary structure is different and would impede the formation of a p97-like hexameric quaternary structure.	Adenosine Diphosphate	89-92	melanotransferrin	Homo sapiens	161-164
26565666-0	2015	Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083).	CB-5083	107-114	melanotransferrin	Homo sapiens	91-94
26712278-0	2016	Structural Basis of ATP Hydrolysis and Intersubunit Signaling in the AAA+ ATPase p97.	Adenosine Triphosphate	20-23	melanotransferrin	Homo sapiens	81-84
26712278-3	2016	Here, we present for the first time crystal structures in which the physiologically relevant p97 hexamer constitutes the content of the asymmetric unit, namely in the apo state without nucleotide in either the D1 or D2 module and in the pre-activated state with ATPgammaS bound to both modules.	adenosine 5'-O-(3-thiotriphosphate)	262-271	melanotransferrin	Homo sapiens	93-96
26712280-5	2016	This finding explains how cofactors like UFD1/NPL4 and p47 can utilize a bipartite binding mechanism to interact simultaneously with the same p97 monomer via their ubiquitin-like domain and SHP motif.	bipartite	73-82	melanotransferrin	Homo sapiens	142-145
26822609-2	2016	We report cryo-electron microscopy (cryo-EM) structures for adenosine diphosphate (ADP)-bound, full-length, hexameric wild-type p97 in the presence and absence of an allosteric inhibitor at resolutions of 2.3 and 2.4 angstroms, respectively.	Adenosine Diphosphate	60-81	melanotransferrin	Homo sapiens	128-131
26822609-2	2016	We report cryo-electron microscopy (cryo-EM) structures for adenosine diphosphate (ADP)-bound, full-length, hexameric wild-type p97 in the presence and absence of an allosteric inhibitor at resolutions of 2.3 and 2.4 angstroms, respectively.	Adenosine Diphosphate	83-86	melanotransferrin	Homo sapiens	128-131
26822609-3	2016	We also report cryo-EM structures (at resolutions of ~3.3, 3.2, and 3.3 angstroms, respectively) for three distinct, coexisting functional states of p97 with occupancies of zero, one, or two molecules of adenosine 5"-O-(3-thiotriphosphate) (ATPgammaS) per protomer.	adenosine 5'-O-(3-thiotriphosphate)	204-239	melanotransferrin	Homo sapiens	149-152
26822609-3	2016	We also report cryo-EM structures (at resolutions of ~3.3, 3.2, and 3.3 angstroms, respectively) for three distinct, coexisting functional states of p97 with occupancies of zero, one, or two molecules of adenosine 5"-O-(3-thiotriphosphate) (ATPgammaS) per protomer.	adenosine 5'-O-(3-thiotriphosphate)	241-250	melanotransferrin	Homo sapiens	149-152
26818443-2	2016	Inclusion of the D1-D2 linker, a 22-amino acid peptide, at the end of p97 N-D1 truncate has been shown to activate ATP hydrolysis of its D1-domain, although the mechanism of activation remains unclear.	Adenosine Triphosphate	115-118	melanotransferrin	Homo sapiens	70-73
26565666-2	2015	Herein we describe our lead optimization efforts focused on in vitro potency, ADME, and pharmaceutical properties that led to the discovery of a potent, ATP-competitive, D2-selective, and orally bioavailable p97 inhibitor 71, CB-5083.	Adenosine Triphosphate	153-156	melanotransferrin	Homo sapiens	208-211
26565666-2	2015	Herein we describe our lead optimization efforts focused on in vitro potency, ADME, and pharmaceutical properties that led to the discovery of a potent, ATP-competitive, D2-selective, and orally bioavailable p97 inhibitor 71, CB-5083.	CB-5083	226-233	melanotransferrin	Homo sapiens	208-211
26985295-0	2016	Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway.	1H-Indole-2-carboxamide	11-23	melanotransferrin	Homo sapiens	38-41
26985295-1	2016	A high-throughput screen to discover inhibitors of p97 ATPase activity identified an indole amide that bound to an allosteric site of the protein.	1H-Indole-2-carboxamide	85-97	melanotransferrin	Homo sapiens	51-54
26073430-5	2015	RESULTS: We demonstrate that Atx3 is SUMOylated at K356 both in vitro and in cells, which contributes for decreased formation of amyloid fibrils and for increased affinity towards p97.	potassium iodate	51-55	melanotransferrin	Homo sapiens	180-183
26475856-1	2015	Valosin-containing protein/p97 is an ATP-driven protein segregase that cooperates with distinct protein cofactors to control various aspects of cellular homeostasis.	Adenosine Triphosphate	37-40	melanotransferrin	Homo sapiens	27-30
26475856-7	2015	NMR titration experiments confirmed a valosin-containing protein/p97 interaction motif and identified a second binding site at helices 1 and 2 of UBXD1-N as binding interfaces for p97.	valosin	38-45	melanotransferrin	Homo sapiens	65-68
26555175-2	2015	We describe the characterization of CB-5083, a potent, selective, and orally bioavailable inhibitor of p97.	CB-5083	36-43	melanotransferrin	Homo sapiens	103-106
26555175-4	2015	In xenograft models, CB-5083 causes modulation of key p97-related pathways, induces apoptosis, and has antitumor activity in a broad range of both hematological and solid tumor models.	CB-5083	21-28	melanotransferrin	Homo sapiens	54-57
24417208-2	2014	During this process, p97 binds polyubiquitinated ERAD substrates and couples ATP hydrolysis to their dislocation from the ER as a prerequisite to destruction by the proteasome.	Adenosine Triphosphate	77-80	melanotransferrin	Homo sapiens	21-24
26006219-0	2015	Withaferin A Analogs That Target the AAA+ Chaperone p97.	withaferin A	0-12	melanotransferrin	Homo sapiens	52-55
26006219-5	2015	Through medicinal chemistry, we have refined the activity of WFA toward p97 and away from the proteasome.	withaferin A	61-64	melanotransferrin	Homo sapiens	72-75
25830243-4	2015	Interestingly, we observed that CSC-induced p97 promoter activation occurs in a dose-dependent manner in both tumor A-549 (lung adenocarcinoma), H-2170 (bronchial carcinoma), SiHa or Hela (cervical carcinoma) cells but not in non-tumor BEAS-2B (bronchial) or NL-20 (alveolar) lung cells unless they ectopically expressed the HPV-16 E6 and E7 oncogenes.	8-(3-Chlorostyryl)caffeine	32-35	melanotransferrin	Homo sapiens	44-47
25377500-3	2015	In contrast, N(2) ,N(4) -dibenzylquinazoline-2,4-diamine (DBeQ) targets both the D1 and D2 domains and shows only a four- to sixfold decrease in potency against the p97-p47 complex.	Nitrogen	13-17	melanotransferrin	Homo sapiens	165-168
25377500-3	2015	In contrast, N(2) ,N(4) -dibenzylquinazoline-2,4-diamine (DBeQ) targets both the D1 and D2 domains and shows only a four- to sixfold decrease in potency against the p97-p47 complex.	n(4) -dibenzylquinazoline-2,4-diamine	19-56	melanotransferrin	Homo sapiens	165-168
25377500-3	2015	In contrast, N(2) ,N(4) -dibenzylquinazoline-2,4-diamine (DBeQ) targets both the D1 and D2 domains and shows only a four- to sixfold decrease in potency against the p97-p47 complex.	N2,N4-dibenzylquinazoline-2,4-diamine	58-62	melanotransferrin	Homo sapiens	165-168
25125376-4	2014	Application of this method to a panel of fungal and plant extracts identified rheoemodin, 1-hydroxydehydroherbarin, and phomapyrrolidone A as distinct p97 modulators.	1-hydroxydehydroherbarin	90-114	melanotransferrin	Homo sapiens	151-154
25125376-4	2014	Application of this method to a panel of fungal and plant extracts identified rheoemodin, 1-hydroxydehydroherbarin, and phomapyrrolidone A as distinct p97 modulators.	phomapyrrolidone A	120-138	melanotransferrin	Homo sapiens	151-154
25713356-9	2015	However, the p97 inhibitor eeyarestatin 1 enhanced immunotoxin killing.	eeyarestatin	27-39	melanotransferrin	Homo sapiens	13-16
24954882-8	2014	DSA-positive patients with mean fluorescence intensity (MFI) >5,000 had 1-year survival of 33.3% compared with 71.4% for MFI 2,000 to 5000 and 62.5% for MFI <2,000 (p = 0.0046).	dsa	0-3	melanotransferrin	Homo sapiens	124-129
25125376-4	2014	Application of this method to a panel of fungal and plant extracts identified rheoemodin, 1-hydroxydehydroherbarin, and phomapyrrolidone A as distinct p97 modulators.	1,3,6,8-tetrahydroxyanthraquinone	78-88	melanotransferrin	Homo sapiens	151-154
24417208-4	2014	In the present paper we report that p97 interacts with Lys11- and Lys48-linked ubiquitin polymers, but not those containing Lys63 linkages.	ubiquitin polymers	79-97	melanotransferrin	Homo sapiens	36-39
23720739-8	2013	Treatment with eeyarestatin I (an inhibitor of p97-dependent protein degradation) resulted in many abundant slowly migrating CX50 and CX50fs bands consistent with polyubiquitination of the proteins.	1-(4-chlorophenyl)-3-(3-(4-chlorophenyl)-5,5-dimethyl-1-(3-(5-nitrofuran-2-yl)allyldienehydrazinocarbonylmethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea	15-29	melanotransferrin	Homo sapiens	47-50
24196964-4	2013	Here, we show that within the hexameric ring of a mutant p97, D1 domains fail to regulate their respective nucleotide-binding states, as evidenced by the lower amount of prebound ADP, weaker ADP binding affinity, full occupancy of adenosine-5"-O-(3-thiotriphosphate) binding, and elevated overall ATPase activity, indicating a loss of communication among subunits.	Adenosine Diphosphate	179-182	melanotransferrin	Homo sapiens	57-60
24196964-4	2013	Here, we show that within the hexameric ring of a mutant p97, D1 domains fail to regulate their respective nucleotide-binding states, as evidenced by the lower amount of prebound ADP, weaker ADP binding affinity, full occupancy of adenosine-5"-O-(3-thiotriphosphate) binding, and elevated overall ATPase activity, indicating a loss of communication among subunits.	Adenosine Diphosphate	191-194	melanotransferrin	Homo sapiens	57-60
24196964-4	2013	Here, we show that within the hexameric ring of a mutant p97, D1 domains fail to regulate their respective nucleotide-binding states, as evidenced by the lower amount of prebound ADP, weaker ADP binding affinity, full occupancy of adenosine-5"-O-(3-thiotriphosphate) binding, and elevated overall ATPase activity, indicating a loss of communication among subunits.	adenosine 5'-O-(3-thiotriphosphate)	231-265	melanotransferrin	Homo sapiens	57-60
24007343-10	2013	Based on additional simulations of SP binding to two allosteric conformations of p97, we propose that transient binding and release of SP from the pore involves a lever mechanism.	sp	35-37	melanotransferrin	Homo sapiens	81-84
24007343-10	2013	Based on additional simulations of SP binding to two allosteric conformations of p97, we propose that transient binding and release of SP from the pore involves a lever mechanism.	sp	135-137	melanotransferrin	Homo sapiens	81-84
24007343-11	2013	Binding to the open pore conformation of p97 occurs primarily at the Arg599 side chain, where the SP backbone is engaged through electrostatic interactions and hydrogen bonds.	sp	98-100	melanotransferrin	Homo sapiens	41-44
24007343-11	2013	Binding to the open pore conformation of p97 occurs primarily at the Arg599 side chain, where the SP backbone is engaged through electrostatic interactions and hydrogen bonds.	Hydrogen	160-168	melanotransferrin	Homo sapiens	41-44
24007343-12	2013	ATP-driven conformational transitions within the D2 ring alter the chemical environment inside the p97 cavity in the closed pore state.	Adenosine Triphosphate	0-3	melanotransferrin	Homo sapiens	99-102
23658965-2	2010	By contrast, these probe compounds were far less potent in blocking degradation of the p97-independent substrate oxygen-dependent degradation domain (ODD)-luciferase (IC50 > 28 muM), underscoring their specificity towards p97.	Oxygen	113-119	melanotransferrin	Homo sapiens	87-90
23658965-2	2010	By contrast, these probe compounds were far less potent in blocking degradation of the p97-independent substrate oxygen-dependent degradation domain (ODD)-luciferase (IC50 > 28 muM), underscoring their specificity towards p97.	Oxygen	113-119	melanotransferrin	Homo sapiens	225-228
23651853-4	2013	1046-1058) report that a protein remodeling machine, the p97-UBXD8 complex, disassembles mRNPs containing the AU-rich elements (AREs) bound by HuR proteins in a nondegradative, ubiquitin signaling-dependent manner, revealing a novel mechanism to regulate mRNA turnover.	Gold	110-112	melanotransferrin	Homo sapiens	57-60
22457434-3	2012	It produces in vitro acrosome alteration and decrease of motility of boar sperm, concomitant with tyrosine phosphorylation of a 97 kDa sperm protein (p97).	Tyrosine	98-106	melanotransferrin	Homo sapiens	150-153
23316025-1	2013	To discover more potent p97 inhibitors, we carried out a structure-activity relationship study of the quinazoline scaffold previously identified from our HTS campaigns.	Quinazolines	102-113	melanotransferrin	Homo sapiens	24-27
23316025-10	2013	Our results nominate ML240 as a promising starting point for the development of a novel agent for the chemotherapy of cancer, and provide a rationale for developing pathway-specific p97 inhibitors.	ML240	21-26	melanotransferrin	Homo sapiens	182-185
23500464-4	2013	We previously reported that p47 phosphorylation on Serine-140 and p37 phosphorylation on Serine-56 and Threonine-59 result in mitotic inhibition of the p97/p47 and the p97/p37 pathways, respectively [11,14].	Serine	51-57	melanotransferrin	Homo sapiens	152-155
23500464-4	2013	We previously reported that p47 phosphorylation on Serine-140 and p37 phosphorylation on Serine-56 and Threonine-59 result in mitotic inhibition of the p97/p47 and the p97/p37 pathways, respectively [11,14].	Serine	51-57	melanotransferrin	Homo sapiens	168-171
23500464-4	2013	We previously reported that p47 phosphorylation on Serine-140 and p37 phosphorylation on Serine-56 and Threonine-59 result in mitotic inhibition of the p97/p47 and the p97/p37 pathways, respectively [11,14].	Serine	89-95	melanotransferrin	Homo sapiens	152-155
23500464-4	2013	We previously reported that p47 phosphorylation on Serine-140 and p37 phosphorylation on Serine-56 and Threonine-59 result in mitotic inhibition of the p97/p47 and the p97/p37 pathways, respectively [11,14].	Serine	89-95	melanotransferrin	Homo sapiens	168-171
23500464-4	2013	We previously reported that p47 phosphorylation on Serine-140 and p37 phosphorylation on Serine-56 and Threonine-59 result in mitotic inhibition of the p97/p47 and the p97/p37 pathways, respectively [11,14].	Threonine	103-112	melanotransferrin	Homo sapiens	152-155
23500464-4	2013	We previously reported that p47 phosphorylation on Serine-140 and p37 phosphorylation on Serine-56 and Threonine-59 result in mitotic inhibition of the p97/p47 and the p97/p37 pathways, respectively [11,14].	Threonine	103-112	melanotransferrin	Homo sapiens	168-171
23500464-6	2013	We clarified that VCIP135, an essential factor in both p97 membrane fusion pathways, is phosphorylated on Threonine-760 and Serine-767 by Cdc2 at mitosis and that this phosphorylated VCIP135 does not bind to p97.	Threonine	106-115	melanotransferrin	Homo sapiens	55-58
23500464-6	2013	We clarified that VCIP135, an essential factor in both p97 membrane fusion pathways, is phosphorylated on Threonine-760 and Serine-767 by Cdc2 at mitosis and that this phosphorylated VCIP135 does not bind to p97.	Threonine	106-115	melanotransferrin	Homo sapiens	208-211
23500464-6	2013	We clarified that VCIP135, an essential factor in both p97 membrane fusion pathways, is phosphorylated on Threonine-760 and Serine-767 by Cdc2 at mitosis and that this phosphorylated VCIP135 does not bind to p97.	Serine	124-130	melanotransferrin	Homo sapiens	55-58
23500464-6	2013	We clarified that VCIP135, an essential factor in both p97 membrane fusion pathways, is phosphorylated on Threonine-760 and Serine-767 by Cdc2 at mitosis and that this phosphorylated VCIP135 does not bind to p97.	Serine	124-130	melanotransferrin	Homo sapiens	208-211
23500464-8	2013	Our results indicate that the phosphorylation of VCIP135 on Threonine-760 and Serine-767 inhibits p97-mediated Golgi membrane fusion at mitosis.	Threonine	60-69	melanotransferrin	Homo sapiens	98-101
23500464-8	2013	Our results indicate that the phosphorylation of VCIP135 on Threonine-760 and Serine-767 inhibits p97-mediated Golgi membrane fusion at mitosis.	Serine	78-84	melanotransferrin	Homo sapiens	98-101
22675116-2	2012	During its ATPase cycle p97 functions as an ATP motor, converting the chemical energy released upon hydrolysis of ATP to ADP into mechanical work, which is then directed toward the proteins that serve as substrates.	Adenosine Triphosphate	11-14	melanotransferrin	Homo sapiens	24-27
22675116-2	2012	During its ATPase cycle p97 functions as an ATP motor, converting the chemical energy released upon hydrolysis of ATP to ADP into mechanical work, which is then directed toward the proteins that serve as substrates.	Adenosine Triphosphate	44-47	melanotransferrin	Homo sapiens	24-27
22675116-2	2012	During its ATPase cycle p97 functions as an ATP motor, converting the chemical energy released upon hydrolysis of ATP to ADP into mechanical work, which is then directed toward the proteins that serve as substrates.	Adenosine Diphosphate	121-124	melanotransferrin	Homo sapiens	24-27
22537386-1	2012	BACKGROUND: The proteins from the UBA-UBX family interact with ubiquitylated proteins via their UBA domain and with p97 via their UBX domain, thereby acting as substrate-binding adaptors for the p97 ATPase.	N-[(S)-({[(Benzyloxy)carbonyl]amino}methyl)(Hydroxy)phosphoryl]-N-Methyl-L-Leucinamide	38-41	melanotransferrin	Homo sapiens	116-119
22537386-1	2012	BACKGROUND: The proteins from the UBA-UBX family interact with ubiquitylated proteins via their UBA domain and with p97 via their UBX domain, thereby acting as substrate-binding adaptors for the p97 ATPase.	N-[(S)-({[(Benzyloxy)carbonyl]amino}methyl)(Hydroxy)phosphoryl]-N-Methyl-L-Leucinamide	38-41	melanotransferrin	Homo sapiens	195-198
22537386-11	2012	We also show that HIF1alpha carrying long ubiquitin-chains can recruit alternative ubiquitin-receptors, lacking p97"s ATP-dependent segregase activity.	Adenosine Triphosphate	118-121	melanotransferrin	Homo sapiens	112-115
22355145-3	2012	During ATP-hydrolysis process, p97 undergoes dramatic conformational changes, and these changes are initiated in the C-terminal ATPase domain and transmitted across the entire length of the molecule to the N-terminal effector domain.	Adenosine Triphosphate	7-10	melanotransferrin	Homo sapiens	31-34
22350894-3	2012	This approach aims to dissect the role played by individual UBX cofactors within the complex array of cellular functions performed by p97.	N-[(S)-({[(Benzyloxy)carbonyl]amino}methyl)(Hydroxy)phosphoryl]-N-Methyl-L-Leucinamide	60-63	melanotransferrin	Homo sapiens	134-137
21739474-0	2011	Crystal structure of FAF1 UBX domain in complex with p97/VCP N domain reveals a conformational change in the conserved FcisP touch-turn motif of UBX domain.	N-[(S)-({[(Benzyloxy)carbonyl]amino}methyl)(Hydroxy)phosphoryl]-N-Methyl-L-Leucinamide	26-29	melanotransferrin	Homo sapiens	53-56
21556036-2	2012	In membrane fusion, p97 is thought to function in analogy to the related ATPase NSF (N-ethylmaleimide-sensitive fusion protein), which promotes membrane fusion by disassembling a SNARE complex.	Ethylmaleimide	85-101	melanotransferrin	Homo sapiens	20-23
21606684-4	2011	We recently identified a small molecule p97 inhibitor, N ( 2) ,N ( 4) -dibenzylquinazoline-2,4-diamine (DBeQ), and documented its effects on blocking autophagic degradation of LC3-II and proteasomal degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate.	N2,N4-dibenzylquinazoline-2,4-diamine	55-102	melanotransferrin	Homo sapiens	40-43
21606684-4	2011	We recently identified a small molecule p97 inhibitor, N ( 2) ,N ( 4) -dibenzylquinazoline-2,4-diamine (DBeQ), and documented its effects on blocking autophagic degradation of LC3-II and proteasomal degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate.	N2,N4-dibenzylquinazoline-2,4-diamine	55-102	melanotransferrin	Homo sapiens	216-219
21606684-4	2011	We recently identified a small molecule p97 inhibitor, N ( 2) ,N ( 4) -dibenzylquinazoline-2,4-diamine (DBeQ), and documented its effects on blocking autophagic degradation of LC3-II and proteasomal degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate.	N2,N4-dibenzylquinazoline-2,4-diamine	104-108	melanotransferrin	Homo sapiens	40-43
21606684-4	2011	We recently identified a small molecule p97 inhibitor, N ( 2) ,N ( 4) -dibenzylquinazoline-2,4-diamine (DBeQ), and documented its effects on blocking autophagic degradation of LC3-II and proteasomal degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate.	N2,N4-dibenzylquinazoline-2,4-diamine	104-108	melanotransferrin	Homo sapiens	216-219
21600962-9	2011	Co-immunoprecipitation study showed that Herp as well as DeltaUb-Herp potentially interacts with nicastrin, mediating nicastrin interaction with p97, which functions in retranslocation of misfolded proteins from the ER to the cytosol.	nicastrin	97-106	melanotransferrin	Homo sapiens	145-148
21600962-9	2011	Co-immunoprecipitation study showed that Herp as well as DeltaUb-Herp potentially interacts with nicastrin, mediating nicastrin interaction with p97, which functions in retranslocation of misfolded proteins from the ER to the cytosol.	nicastrin	118-127	melanotransferrin	Homo sapiens	145-148
21600962-10	2011	CONCLUSIONS: Thus, Herp is likely involved in degradation of immature nicastrin by facilitating p97-dependent nicastrin retranslocation and ubiquitination.	nicastrin	70-79	melanotransferrin	Homo sapiens	96-99