PMID-sentid Pub_year Sent_text comp_official_name comp_offset protein_name organism prot_offset 2657451-5 1989 The patients were advised to use this pen every time the blood glucose concentration exceeded 10 mmol/l or when this was expected; extra attention was paid to the lunch time and afternoon snacks. Blood Glucose 57-70 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 38-41 2806082-2 1989 Close scrutiny of the individual components of this surgical marking pen revealed contact dermatitis to ninhydrine, a substance whose allergenic potential has hardly been noted in the relevant literature. Ninhydrin 104-114 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 69-72 3551672-5 1987 The production of interleukin-2 and B cell growth factor by phytohaemagglutinin-stimulated T cells was not inhibited by D-Pen; again D-Pen + Cu2+ markedly reduced the production of these cytokines. cupric ion 141-145 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 135-138 2703832-3 1989 The experimental data may be explained by the formation of the complexes T1(Cys)-, T1(Cys)H, T1(Pen)-, T1(Pen)H, T1(Acy)-, and T1(Ape)- with log formation constants 3.26, 11.28, 3.60, 12.05, 2.27, and 2.45, respectively. Cysteine 76-79 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 106-109 2835652-4 1988 This study also includes seven cyclic pentapeptides of the type: Tyr-Cys(Pen-Gly-Phe-Cys(Pen) with various combinations of DL-cysteine and DL-penicillamine (beta-dimethyl cysteine) as the second and fifth residues resulting in varying delta affinities and selectivities. cyclic pentapeptides 31-51 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 89-92 2835652-4 1988 This study also includes seven cyclic pentapeptides of the type: Tyr-Cys(Pen-Gly-Phe-Cys(Pen) with various combinations of DL-cysteine and DL-penicillamine (beta-dimethyl cysteine) as the second and fifth residues resulting in varying delta affinities and selectivities. Tyr-Cys 65-72 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 73-76 2835652-4 1988 This study also includes seven cyclic pentapeptides of the type: Tyr-Cys(Pen-Gly-Phe-Cys(Pen) with various combinations of DL-cysteine and DL-penicillamine (beta-dimethyl cysteine) as the second and fifth residues resulting in varying delta affinities and selectivities. Tyr-Cys 65-72 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 89-92 2896638-0 1988 Conformation of D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 (CTP-NH2), a highly selective mu-opioid antagonist peptide, by 1H and 13C n.m.r. Ctp-srih 57-64 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 44-47 2896638-0 1988 Conformation of D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 (CTP-NH2), a highly selective mu-opioid antagonist peptide, by 1H and 13C n.m.r. Hydrogen 119-121 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 44-47 2896638-0 1988 Conformation of D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 (CTP-NH2), a highly selective mu-opioid antagonist peptide, by 1H and 13C n.m.r. 13c 126-129 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 44-47 2896638-2 1988 spectral parameters of CTP-NH2 [D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2], a potent, highly selective mu-opiate antagonist, were measured in aqueous solution and a possible conformation has been deduced from the spectral data. Ctp-srih 23-30 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 60-63 2896638-4 1988 Solvent shielding of the Cys2 amide proton, observed in variable temperature experiments, suggests an orientation of this amide proton toward the gem dimethyls of Pen7 with possible hydrogen bonding to the Thr6 carbonyl oxygen, and a dihedral angle of -110 degrees for the disulfide bond. cys2 amide 25-35 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 163-166 2896638-4 1988 Solvent shielding of the Cys2 amide proton, observed in variable temperature experiments, suggests an orientation of this amide proton toward the gem dimethyls of Pen7 with possible hydrogen bonding to the Thr6 carbonyl oxygen, and a dihedral angle of -110 degrees for the disulfide bond. Amides 30-35 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 163-166 2896638-4 1988 Solvent shielding of the Cys2 amide proton, observed in variable temperature experiments, suggests an orientation of this amide proton toward the gem dimethyls of Pen7 with possible hydrogen bonding to the Thr6 carbonyl oxygen, and a dihedral angle of -110 degrees for the disulfide bond. Hydrogen 182-190 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 163-166 2896638-4 1988 Solvent shielding of the Cys2 amide proton, observed in variable temperature experiments, suggests an orientation of this amide proton toward the gem dimethyls of Pen7 with possible hydrogen bonding to the Thr6 carbonyl oxygen, and a dihedral angle of -110 degrees for the disulfide bond. Oxygen 220-226 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 163-166 2896638-4 1988 Solvent shielding of the Cys2 amide proton, observed in variable temperature experiments, suggests an orientation of this amide proton toward the gem dimethyls of Pen7 with possible hydrogen bonding to the Thr6 carbonyl oxygen, and a dihedral angle of -110 degrees for the disulfide bond. Disulfides 273-282 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 163-166 2882186-0 1987 Pen-sized digital 30-second blood glucose meter. Blood Glucose 28-41 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 0-3 2463265-2 1989 D-Pen, in the presence of copper sulfate, suppressed tritiated thymidine ([3H]TdR) incorporation into EC in a dose-dependent manner. Copper Sulfate 26-40 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 2-5 2463265-2 1989 D-Pen, in the presence of copper sulfate, suppressed tritiated thymidine ([3H]TdR) incorporation into EC in a dose-dependent manner. Tritiated thymidine 53-72 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 2-5 2463265-2 1989 D-Pen, in the presence of copper sulfate, suppressed tritiated thymidine ([3H]TdR) incorporation into EC in a dose-dependent manner. Tritium 75-77 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 2-5 2463265-7 1989 These results suggest that hydrogen peroxide generated by D-Pen and copper exerts a pronounced antiangiogenic effect through inhibition of EC proliferation. Hydrogen Peroxide 27-44 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 60-63 3017877-1 1986 Collagen production was investigated in cultured rabbit synovial fibroblasts exposed in vitro to D-penicillamine (D-Pen). Penicillamine 97-112 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 116-119 3495717-1 1987 Binding of D-Penicillamine (D-Pen) to human monocytes was examined by flow cytometry with fluorescent D-Pen conjugate. Penicillamine 11-26 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 30-33 3948434-1 1986 Long-term therapy of D-penicillamine (D-Pen) for rheumatoid arthritis (RA) is associated with a fall in rheumatoid factor, but many patients develop autoantibodies. Penicillamine 21-36 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 40-43 2415613-5 1986 The thiol (-SH) group of D-Pen was required for generating effective stimulator cells; other thiol compounds, however, or heavy metals (Hg, Au) were unable to generate cross-reacting stimulators on incubation with spleen cells. Sulfhydryl Compounds 4-9 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 27-30 6335884-1 1984 L-Histidine (L-His) and human serum albumin (HSA) at physiological concentrations, like the exogenous ligands D-penicillamine (D-PEN) and EDTA, are shown to inhibit the uptake of physiological levels of Ni2+ by B-lymphoblasts of human origin, human erythrocytes and rabbit alveolar macrophages. Histidine 0-11 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 129-132 6335884-1 1984 L-Histidine (L-His) and human serum albumin (HSA) at physiological concentrations, like the exogenous ligands D-penicillamine (D-PEN) and EDTA, are shown to inhibit the uptake of physiological levels of Ni2+ by B-lymphoblasts of human origin, human erythrocytes and rabbit alveolar macrophages. Histidine 0-5 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 129-132 2578436-2 1985 The binding of Pen 4 to carrier-bound penicillin derivatives was shown in an ELISA to be dependent on the structure of the side chain in the derivative. Penicillins 38-48 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 15-18 2578436-4 1985 From the difference in binding to carrier-bound penicillin derivatives in a competitive enzyme immunoassay it was concluded that Pen 7 mainly recognizes the new antigenic determinant which emerges from the binding of the penicillin derivative to a carrier. Penicillins 48-58 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 129-132 2578436-4 1985 From the difference in binding to carrier-bound penicillin derivatives in a competitive enzyme immunoassay it was concluded that Pen 7 mainly recognizes the new antigenic determinant which emerges from the binding of the penicillin derivative to a carrier. Penicillins 221-231 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 129-132 2578436-5 1985 The binding of Pen 9 to carrier-bound penicillin derivatives was not influenced by the nature of the side chain. Penicillins 38-48 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 15-18 2578436-7 1985 Therefore it is concluded that Pen 9 mainly recognizes the thiazolidine ring of penicillin. Thiazolidines 59-71 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 31-34 2578436-7 1985 Therefore it is concluded that Pen 9 mainly recognizes the thiazolidine ring of penicillin. Penicillins 80-90 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 31-34 6723124-1 1984 The effects of D-penicillamine (D-Pen) in rheumatoid arthritis suggest that the drug may be anti-inflammatory and immunosuppressive. Penicillamine 15-30 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 34-37 6526052-4 1984 Quantitative evaluation of uptake of radionuclide was obtained by calculating the ratio of the number of counts per pixel in pagetoid bone with that in comparable normal bone; measurements were performed by a computer interfaced to the gamma camera, after marking the regions of interest with a light-pen. Radioisotopes 37-49 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 301-304 6335884-1 1984 L-Histidine (L-His) and human serum albumin (HSA) at physiological concentrations, like the exogenous ligands D-penicillamine (D-PEN) and EDTA, are shown to inhibit the uptake of physiological levels of Ni2+ by B-lymphoblasts of human origin, human erythrocytes and rabbit alveolar macrophages. Penicillamine 110-125 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 129-132 6335884-1 1984 L-Histidine (L-His) and human serum albumin (HSA) at physiological concentrations, like the exogenous ligands D-penicillamine (D-PEN) and EDTA, are shown to inhibit the uptake of physiological levels of Ni2+ by B-lymphoblasts of human origin, human erythrocytes and rabbit alveolar macrophages. Nickel(2+) 203-207 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 129-132 119204-1 1979 83 in-patients, age 3 months to 12 years, with tonsillitis, otitis, bronchitis and pneumonia were treated with a new galenic preparation of phenoxymethylpenicillin V potassium (Star-Pen Trockensirus SANABO). phenoxymethylpenicillin v potassium 140-175 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 182-185 6230447-1 1983 Different inhibitory effects on the mixed leukocyte reaction were noted with sodium aurothiomalate (GSTM) and D-penicillamine (D-Pen) depending on the lymphocyte/macrophage ratio of responder cell populations. Penicillamine 110-125 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 129-132 16725863-8 1983 Testosterone propionate-treated mares and the stallion mounted an estrous mare 23.3 +/- 9.7 seconds and 172.5 +/- 22.5 seconds, respectively, after being introduced into the pen. Testosterone Propionate 0-23 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 174-177 6267115-14 1981 These results support the position that testing with PPL, PA, and Pen G is a rapid, safe, and effective method for identifying patients at risk, or not at risk, for allergic reactions to penicillin. Penicillins 187-197 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 66-69 7005521-1 1980 A prospective clinical trial in couples was done to compare effectiveness and toxicity of gold and D-penicillamine (D-Pen.) Penicillamine 99-114 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 118-121 1085099-1 1976 The D-penicillamine (D-Pen.) Penicillamine 4-19 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 23-26 830674-0 1977 Model for the binding of D-penicillamine to metal ions in living systems: Synthesis and structure of L-histidinyl-D-penicillaminatocobalt(III) monohydrate, [Co(L-His)(D-Pen)]-H2O. Penicillamine 25-40 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 169-172 830674-0 1977 Model for the binding of D-penicillamine to metal ions in living systems: Synthesis and structure of L-histidinyl-D-penicillaminatocobalt(III) monohydrate, [Co(L-His)(D-Pen)]-H2O. l-histidinyl-d-penicillaminatocobalt(iii) monohydrate 101-154 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 169-172 830674-0 1977 Model for the binding of D-penicillamine to metal ions in living systems: Synthesis and structure of L-histidinyl-D-penicillaminatocobalt(III) monohydrate, [Co(L-His)(D-Pen)]-H2O. co(l-his) 157-166 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 169-172 287191-1 1979 The inhibitory effects of D-penicillamine (D-Pen) on lymphocyte activation by PHA are found to be dose-dependent, showing significant effects above a concentration of 50 microgram/ml. Penicillamine 26-41 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 45-48 287191-4 1979 The supplementation of culture medium with L-cysteine abolishes the inhibitory effect of D-Pen, whilst copper sulphate synergistically inhibits PHA-induced transformation. Cysteine 43-53 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 91-94 874544-5 1977 The fall in end tical CO2 occurred at 0.5 to 1.0 cc/kg of intravenously injected air and was confirmed by pen write-out. N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)-4-((4-fluorobenzyl)oxy)pyridine-2,6-dicarboxamide 22-25 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 106-109 33991326-1 2021 INTRODUCTION: In a pivotal study, apomorphine sublingual film (APL; KYNMOBI ) was an effective and generally well-tolerated on-demand treatment of "OFF" episodes in patients with Parkinson"s disease (PD), approved across the dose range of 10-30 mg. Pharmacokinetics and comparative bioavailability of APL and two subcutaneous (SC) apomorphine formulations (SC-APO [APOKYN ] and SC-APO-GO [APO-go PEN]) were evaluated in a randomized, three-way crossover, open-label study (NCT03292016). Apomorphine 34-45 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 397-400 5447542-1 1970 A new polyethylene paper may be marked on a hard surface with an ordinary oversize ball-point pen or dull pencil point. Polyethylene 6-18 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 94-97 34008442-6 2021 RESULTS: Both the patch and pen groups achieved recommended targets in %TIR (74.1% +- 18.7%, 75.2 +- 16.1%, respectively) and marked reductions in %TAR >180 mg/dL (21.1% +- 19.9%, 19.7% +- 17.5%, respectively) but with increased %TBR <70 mg/dL (4.7% +- 5.2%, 5.1 +- 5.8, respectively), all P < .0001. tbr 230-233 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 28-31 34008442-8 2021 CONCLUSIONS: CGM confirmed that the patch or pen can be used to safely initiate and optimize basal-bolus therapy using a simple insulin adjustment algorithm with SMBG. cgm 13-16 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 45-48 34008442-8 2021 CONCLUSIONS: CGM confirmed that the patch or pen can be used to safely initiate and optimize basal-bolus therapy using a simple insulin adjustment algorithm with SMBG. smbg 162-166 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 45-48 33636492-1 2021 Herein, fluorescent DNA-templated silver nanoclusters (DNA-AgNCs) with red emission were synthesized and utilized as novel probe to detect D-penicillamine (D-Pen) for the first time. Penicillamine 139-154 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 158-161 33636492-2 2021 D-Pen molecules contain a thiol which can combine with Ag to form a non-fluorescent ground state complex, inducing the aggregation of DNA-AgNCs followed by the fluorescence quenching. Sulfhydryl Compounds 26-31 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 2-5 1118603-1 1975 D-pencillamine labeled with 99mTc (Tc-Pen) was used for cholescintigraphy in dogs and man. d-pencillamine 0-14 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 38-41 33948925-0 2021 Evaluation of the Octreotide Acetate Pen Injector and its Instructions for Use in a Formative Human Factors Study. Octreotide 18-36 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 37-40 33948925-2 2021 This formative human factors study assessed the octreotide acetate pen injector and accompanying instructions for use (IFU) with self-trained participants. Octreotide 48-66 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 67-70 33948925-12 2021 CONCLUSION: The octreotide pen injector and IFU were usable by self-trained participants. Octreotide 16-26 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 27-30 33964212-5 2021 Moreover, Pen-cRaf-v1 exhibits excellent activity comparable with a leading pan-RAS inhibitor (BI-2852), as well as high target specificity in transcriptome analysis and alanine mutation analysis. BI-2852 95-102 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 10-13 33861901-2 2021 Herein, we report a new ladder-type bis(1,4-oxaborine)pentacene (BO-Pen), the backbone of which can be regarded as an isoelectronic structure of pentacene. bis(1,4-oxaborine)pentacene 36-63 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 68-71 33964212-5 2021 Moreover, Pen-cRaf-v1 exhibits excellent activity comparable with a leading pan-RAS inhibitor (BI-2852), as well as high target specificity in transcriptome analysis and alanine mutation analysis. Alanine 170-177 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 10-13 33967938-0 2021 Multicenter Interventional Phase IV Study for the Assessment of the Effects on Patient"s Satisfaction of Peg IFN Beta-1a (Pre-filled Pen) in Subjects With Relapsing-Remitting Multiple Sclerosis Unsatisfied With Other Injectable Subcutaneous Interferons (PLATINUM Study). peg ifn 105-112 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 133-136 33967938-0 2021 Multicenter Interventional Phase IV Study for the Assessment of the Effects on Patient"s Satisfaction of Peg IFN Beta-1a (Pre-filled Pen) in Subjects With Relapsing-Remitting Multiple Sclerosis Unsatisfied With Other Injectable Subcutaneous Interferons (PLATINUM Study). Platinum 254-262 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 133-136 33843291-11 2021 A number of gaps were identified and interventions were undertaken to reduce insulin pen waste, which resulted in a significant decrease in both aspart (p = 0.0002) and glargine (p = 0.0005) pens/patient over time. Insulin Aspart 145-151 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 85-88 33843291-11 2021 A number of gaps were identified and interventions were undertaken to reduce insulin pen waste, which resulted in a significant decrease in both aspart (p = 0.0002) and glargine (p = 0.0005) pens/patient over time. Insulin Glargine 169-177 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 85-88 33861901-2 2021 Herein, we report a new ladder-type bis(1,4-oxaborine)pentacene (BO-Pen), the backbone of which can be regarded as an isoelectronic structure of pentacene. pentacene 54-63 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 68-71 33861901-5 2021 Compound BO-Pen is stable (even after 160 h) under ambient condition and exhibits very different electronic properties as compared to its all-carbon pentacene analogue (Pen-M). carbon pentacene 142-158 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 12-15 33250420-2 2021 Herein, a polyethylenimine (PEI) derivative, N-isopropylacrylamide-modified PEI (namely PEN), was constructed through Michael addition and then employed as a carrier for miR-29a transfection. Polyethyleneimine 10-26 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 88-91 33500029-1 2021 SiCOH thin films were deposited on rigid silicon (Si) wafers and flexible ITO/PEN substrates via plasma-enhanced chemical vapor deposition at room temperature using a tetrakis(trimethylsilyloxy)silane (TTMSS) precursor. sicoh 0-5 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 78-81 33725437-0 2021 Closed-Loop Nanopatterning of Liquids with Dip-Pen Nanolithography. liquids 30-37 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 47-50 33739925-5 2021 In this paper, we present a novel smart pen-shaped electronic system for continuous monitoring of propofol in human serum. Propofol 98-106 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 40-43 33500029-1 2021 SiCOH thin films were deposited on rigid silicon (Si) wafers and flexible ITO/PEN substrates via plasma-enhanced chemical vapor deposition at room temperature using a tetrakis(trimethylsilyloxy)silane (TTMSS) precursor. Silicon 0-2 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 78-81 33633292-0 2021 Sacrificial gold coating enhances transport of liquid metal in pressurized fountain pen lithography. Metals 54-59 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 84-87 33633292-4 2021 This work presents an injection technique based on pressurized fountain pen lithography with glass nanopipettes developed to directly pattern liquid metal on flat hard substrates. Metals 149-154 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 72-75 33250420-2 2021 Herein, a polyethylenimine (PEI) derivative, N-isopropylacrylamide-modified PEI (namely PEN), was constructed through Michael addition and then employed as a carrier for miR-29a transfection. Polyethyleneimine 28-31 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 88-91 33250420-2 2021 Herein, a polyethylenimine (PEI) derivative, N-isopropylacrylamide-modified PEI (namely PEN), was constructed through Michael addition and then employed as a carrier for miR-29a transfection. N-isopropylacrylamide 45-66 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 88-91 33250420-3 2021 The carrier PEN has been demonstrated to possess favorable ability to condense miR-29a into stable nanoparticles and protect miR-29a against the nuclease degradation, using agarose gel retardation assay. Sepharose 173-180 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 12-15 32673472-14 2020 Silano-Pen after hot acid improved the bonding of zirconia. hot acid 17-25 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 7-10 33347284-0 2021 Multifunctional and Ultrasensitive-Reduced Graphene Oxide and Pen Ink/Polyvinyl Alcohol-Decorated Modal/Spandex Fabric for High-Performance Wearable Sensors. Polyvinyl Alcohol 70-87 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 62-65 33390019-2 2021 Herein, the light incident angle is utilized to control the motion behavior of silica/Au/pentacene (SiO2/Au/PEN) spherical Janus micromotor. Silicon Dioxide 79-85 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 108-111 33390019-2 2021 Herein, the light incident angle is utilized to control the motion behavior of silica/Au/pentacene (SiO2/Au/PEN) spherical Janus micromotor. Gold 86-88 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 108-111 33390019-2 2021 Herein, the light incident angle is utilized to control the motion behavior of silica/Au/pentacene (SiO2/Au/PEN) spherical Janus micromotor. pentacene 89-98 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 108-111 33390019-2 2021 Herein, the light incident angle is utilized to control the motion behavior of silica/Au/pentacene (SiO2/Au/PEN) spherical Janus micromotor. Silicon Dioxide 100-104 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 108-111 33390019-4 2021 Interestingly, when the incident light is tuned to the vertical angle, the SiO2/Au/PEN micromotor stops moving. Silicon Dioxide 75-79 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 83-86 33390019-4 2021 Interestingly, when the incident light is tuned to the vertical angle, the SiO2/Au/PEN micromotor stops moving. Gold 80-82 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 83-86 33390019-5 2021 Similarly, a number of SiO2/Au/PEN micromotors exhibit the same "on-off" motion change, which is dependent on the light incident angle. Silicon Dioxide 23-27 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 31-34 33390019-5 2021 Similarly, a number of SiO2/Au/PEN micromotors exhibit the same "on-off" motion change, which is dependent on the light incident angle. Gold 28-30 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 31-34 33390019-6 2021 More interestingly, the "on-off" motion of the SiO2/Au/PEN microparticles under vertical light irradiation results in the formation of the agglomeration with position and size precisely controlled by light. Silicon Dioxide 47-51 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 55-58 33390019-6 2021 More interestingly, the "on-off" motion of the SiO2/Au/PEN microparticles under vertical light irradiation results in the formation of the agglomeration with position and size precisely controlled by light. Gold 52-54 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 55-58 33467148-3 2021 The +HC treatment involved a familiar stockperson patting and scratching sows and was imposed at a pen-level for 2 min daily. Hydrocortisone 5-7 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 99-102 33076078-1 2021 In2O3-10%SnO2 (ITO) thin films on various substrates have been obtained by pen plotter printing using a solution of hydrolytically active heteroligand complexes [M(C5H7O2)x(C4H9O)y] (where M = In3+ and Sn4+) as a functional ink. Indium oxide (In2O3) 0-5 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 75-78 33076078-1 2021 In2O3-10%SnO2 (ITO) thin films on various substrates have been obtained by pen plotter printing using a solution of hydrolytically active heteroligand complexes [M(C5H7O2)x(C4H9O)y] (where M = In3+ and Sn4+) as a functional ink. Tin(IV) oxide 9-13 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 75-78 32735382-2 2020 The potassium salt 1 , [Kpdl*], was treated with ClSiMe 2 NH t Bu, and the resulting pentadiene 2 was deprotonated with the Schlosser -type base KO t Pen/ n -BuLi ( t Pen = CMe 2 (CH 2 Me)) to yield the dipotassium salt [K 2 (pdl*SiMe 2 N t Bu)] ( 3 ). POTASSIUM BENZOATE 4-18 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 150-153 32735382-2 2020 The potassium salt 1 , [Kpdl*], was treated with ClSiMe 2 NH t Bu, and the resulting pentadiene 2 was deprotonated with the Schlosser -type base KO t Pen/ n -BuLi ( t Pen = CMe 2 (CH 2 Me)) to yield the dipotassium salt [K 2 (pdl*SiMe 2 N t Bu)] ( 3 ). POTASSIUM BENZOATE 4-18 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 167-170 32735382-2 2020 The potassium salt 1 , [Kpdl*], was treated with ClSiMe 2 NH t Bu, and the resulting pentadiene 2 was deprotonated with the Schlosser -type base KO t Pen/ n -BuLi ( t Pen = CMe 2 (CH 2 Me)) to yield the dipotassium salt [K 2 (pdl*SiMe 2 N t Bu)] ( 3 ). Alkadienes 85-95 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 150-153 33341775-1 2020 A new kind of flat sheet ultrafiltration membrane was prepared by a promising membrane material, poly (aryl ether nitrile) (PEN), via non-solvent induced phase separation. poly (aryl ether nitrile) 97-122 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 124-127 32993994-0 2020 Pen sensor made with silver nanoparticles decorating graphite-polyurethane electrodes to detect bisphenol-A in tap and river water samples. Silver 21-27 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 0-3 32233934-11 2020 Durable delivery pen like NovoPen 4 maintain accuracy and low dose force compared to vials and syringes. novopen 4 26-36 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 17-20 32980099-4 2020 The surface treatment of the carbon black/PLA electrodes fabricated by both 3D pen and FDM 3D-printing procedures provided substantial improvement of the electrochemical activity by removing excess of PLA, which was confirmed by scanning electron microscopic images for electrodes fabricated by both procedures. Carbon 29-35 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 79-82 32730172-1 2020 Roquefortine, also known as roquefortine C (ROQC) is a fungal secondary metabolite (mycotoxin) that is produced by some of the same Penicillia as the tremorgen penitrem-A (PEN-A). roquefortine 0-12 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 172-175 32730172-1 2020 Roquefortine, also known as roquefortine C (ROQC) is a fungal secondary metabolite (mycotoxin) that is produced by some of the same Penicillia as the tremorgen penitrem-A (PEN-A). roquefortine 28-42 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 172-175 32730172-1 2020 Roquefortine, also known as roquefortine C (ROQC) is a fungal secondary metabolite (mycotoxin) that is produced by some of the same Penicillia as the tremorgen penitrem-A (PEN-A). roquefortine 44-48 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 172-175 32986771-0 2020 Repeatability, reproducibility, agreement, and safety of Tono-Pen tip cover for intraocular measurement using latex and polyethylene wrap. Polyethylene 120-132 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 62-65 32986771-3 2020 A gas-sterilized, polyethylene wrap was used as an alternative for Tono-Pen tip cover. Polyethylene 18-30 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 72-75 32993994-0 2020 Pen sensor made with silver nanoparticles decorating graphite-polyurethane electrodes to detect bisphenol-A in tap and river water samples. Graphite 53-61 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 0-3 32993994-0 2020 Pen sensor made with silver nanoparticles decorating graphite-polyurethane electrodes to detect bisphenol-A in tap and river water samples. Polyurethanes 62-74 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 0-3 32993994-0 2020 Pen sensor made with silver nanoparticles decorating graphite-polyurethane electrodes to detect bisphenol-A in tap and river water samples. bisphenol A 96-107 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 0-3 32993994-0 2020 Pen sensor made with silver nanoparticles decorating graphite-polyurethane electrodes to detect bisphenol-A in tap and river water samples. Water 125-130 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 0-3 32993994-2 2020 In this paper, we report on a new design of a complete electrochemical system whose working (WE), auxiliary (AE) and reference (RE) electrodes were obtained on a pen (PEN Sensor) made with graphite:polyurethane (GPUE). Polyurethanes 198-210 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 162-165 32993994-2 2020 In this paper, we report on a new design of a complete electrochemical system whose working (WE), auxiliary (AE) and reference (RE) electrodes were obtained on a pen (PEN Sensor) made with graphite:polyurethane (GPUE). Polyurethanes 198-210 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 167-170 32993994-6 2020 The PEN Sensor could also detect bisphenol-A in tap and river water samples, with satisfactory reproducibility and repeatability, while common interferents did not affect electrooxidation of bisphenol-A. bisphenol A 33-44 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 32993994-6 2020 The PEN Sensor could also detect bisphenol-A in tap and river water samples, with satisfactory reproducibility and repeatability, while common interferents did not affect electrooxidation of bisphenol-A. Water 62-67 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 32993994-6 2020 The PEN Sensor could also detect bisphenol-A in tap and river water samples, with satisfactory reproducibility and repeatability, while common interferents did not affect electrooxidation of bisphenol-A. bis(4-hydroxyphenyl)sulfone 33-43 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 32825582-3 2020 This study assesses the use of synthetic human tubal fluid (HTF) supplemented with D-penicillamine (HTF + PEN) for the in vitro capacitation of frozen/thawed stallion spermatozoa by examining capacitation-related events over 180 min of incubation. Penicillamine 83-98 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 106-109 32906893-4 2020 As a result, light extraction efficiency of the flexible OLEDs on PEN substrates was enhanced by a factor of 1.65 by the incorporation of the scattering layer, with the highest Al2O3 NP concentration of 99 wt%. al2o3 np 177-185 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 66-69 32645209-2 2020 In this experiment, a new kind of electrochemical sensor is prepared based on magnetic mesoporous hollow carbon microspheres (MHM) as a penicillinase (Pen X) adsorption carrier to rapidly detect penicillin sodium (Pen G), named Pen X/MHM/MGCE. mesoporous 87-97 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 151-154 32645209-2 2020 In this experiment, a new kind of electrochemical sensor is prepared based on magnetic mesoporous hollow carbon microspheres (MHM) as a penicillinase (Pen X) adsorption carrier to rapidly detect penicillin sodium (Pen G), named Pen X/MHM/MGCE. mesoporous 87-97 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 214-217 32645209-2 2020 In this experiment, a new kind of electrochemical sensor is prepared based on magnetic mesoporous hollow carbon microspheres (MHM) as a penicillinase (Pen X) adsorption carrier to rapidly detect penicillin sodium (Pen G), named Pen X/MHM/MGCE. mesoporous 87-97 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 214-217 32645209-2 2020 In this experiment, a new kind of electrochemical sensor is prepared based on magnetic mesoporous hollow carbon microspheres (MHM) as a penicillinase (Pen X) adsorption carrier to rapidly detect penicillin sodium (Pen G), named Pen X/MHM/MGCE. Carbon 105-111 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 151-154 32645209-2 2020 In this experiment, a new kind of electrochemical sensor is prepared based on magnetic mesoporous hollow carbon microspheres (MHM) as a penicillinase (Pen X) adsorption carrier to rapidly detect penicillin sodium (Pen G), named Pen X/MHM/MGCE. Carbon 105-111 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 214-217 32645209-2 2020 In this experiment, a new kind of electrochemical sensor is prepared based on magnetic mesoporous hollow carbon microspheres (MHM) as a penicillinase (Pen X) adsorption carrier to rapidly detect penicillin sodium (Pen G), named Pen X/MHM/MGCE. Carbon 105-111 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 214-217 32645209-2 2020 In this experiment, a new kind of electrochemical sensor is prepared based on magnetic mesoporous hollow carbon microspheres (MHM) as a penicillinase (Pen X) adsorption carrier to rapidly detect penicillin sodium (Pen G), named Pen X/MHM/MGCE. Penicillin G 195-212 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 151-154 32645209-2 2020 In this experiment, a new kind of electrochemical sensor is prepared based on magnetic mesoporous hollow carbon microspheres (MHM) as a penicillinase (Pen X) adsorption carrier to rapidly detect penicillin sodium (Pen G), named Pen X/MHM/MGCE. Penicillin G 195-212 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 214-217 32645209-2 2020 In this experiment, a new kind of electrochemical sensor is prepared based on magnetic mesoporous hollow carbon microspheres (MHM) as a penicillinase (Pen X) adsorption carrier to rapidly detect penicillin sodium (Pen G), named Pen X/MHM/MGCE. Penicillin G 195-212 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 214-217 33018576-0 2020 High-Throughput Vascular Screening by ARTSENS Pen During a Medical Camp for Early-Stage Detection of Chronic Kidney Disease. Cyclic AMP 67-71 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 46-49 32708529-1 2020 Penicillin non-susceptible Streptococcus agalactiae (PEN-NS GBS) has been increasingly reported, with multidrug-resistant (MDR) GBS documented in Japan. Penicillins 0-10 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 53-56 32716310-2 2020 In the European Union, CZP is approved for administration by subcutaneous self-injection using a prefilled syringe, prefilled pen, or reusable electromechanical auto-injector (electronic device). Certolizumab Pegol 23-26 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 126-129 32380353-3 2020 In this work, phenoxymethylpenicillin potassium (Pen V) was selected to find a way to quickly establish a robust analysis method for the impurity profiling of penicillin. Penicillin V 14-47 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 49-52 32380353-3 2020 In this work, phenoxymethylpenicillin potassium (Pen V) was selected to find a way to quickly establish a robust analysis method for the impurity profiling of penicillin. Penicillins 27-37 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 49-52 32176248-16 2020 Conclusions and Relevance: In this study, PEN-FAST was found to be a simple rule that accurately identified low-risk penicillin allergies that do not require formal allergy testing. Penicillins 117-127 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 42-45 32604746-0 2020 Controlling the Size and Pattern Pitch of Ni(OH)2 Nanoclusters Using Dip-Pen Nanolithography to Improve Water Oxidation. nickel hydroxide 42-49 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 73-76 32604746-0 2020 Controlling the Size and Pattern Pitch of Ni(OH)2 Nanoclusters Using Dip-Pen Nanolithography to Improve Water Oxidation. Water 104-109 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 73-76 32604746-1 2020 We use dip-pen nanolithography to accurately pattern Ni(OH)2 nanoclusters on a metachemical surface with an exceptionally large surface area. nickel hydroxide 53-60 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 11-14 32556737-0 2020 Ratiometric fluorescent test pen filled with a mixing ink of carbon dots and CdTe quantum dots for portable assay of silver ion on paper. Carbon 61-67 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 29-32 32556737-0 2020 Ratiometric fluorescent test pen filled with a mixing ink of carbon dots and CdTe quantum dots for portable assay of silver ion on paper. cadmium telluride 77-81 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 29-32 32556737-0 2020 Ratiometric fluorescent test pen filled with a mixing ink of carbon dots and CdTe quantum dots for portable assay of silver ion on paper. Silver 117-123 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 29-32 32556737-1 2020 A ratiometric fluorescent test pen filled with a mixing ink of blue carbon dots (CDs) and red CdTe quantum dots (CdTe QDs) is introduced for portable assay of silver ion (Ag(I)) on paper. Methane 68-79 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 31-34 32556737-1 2020 A ratiometric fluorescent test pen filled with a mixing ink of blue carbon dots (CDs) and red CdTe quantum dots (CdTe QDs) is introduced for portable assay of silver ion (Ag(I)) on paper. cds 81-84 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 31-34 32556737-1 2020 A ratiometric fluorescent test pen filled with a mixing ink of blue carbon dots (CDs) and red CdTe quantum dots (CdTe QDs) is introduced for portable assay of silver ion (Ag(I)) on paper. cadmium telluride 94-98 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 31-34 32556737-1 2020 A ratiometric fluorescent test pen filled with a mixing ink of blue carbon dots (CDs) and red CdTe quantum dots (CdTe QDs) is introduced for portable assay of silver ion (Ag(I)) on paper. Silver 159-165 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 31-34 32351768-2 2020 We report a case involving a 16-year-old female who presented with fever, nonproductive cough, and shortness of breath after vaping e-cig/tetrahydrocannabinol dab pen. Dronabinol 138-158 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 163-166 32351768-2 2020 We report a case involving a 16-year-old female who presented with fever, nonproductive cough, and shortness of breath after vaping e-cig/tetrahydrocannabinol dab pen. diazobenzenesulfonic acid 159-162 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 163-166 32253911-3 2020 In this study, we dip the commercially available spandex/polyamide fabric into carbonic pen ink to prepare a textile strain sensor with good skin affinity. spandex/polyamide 49-66 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 88-91 31480497-0 2019 Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879). Terpenes 15-25 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 48-51 32124272-1 2020 INTRODUCTION: The CIMZIA AutoClicks pre-filled pen (CZP PFP) was developed to overcome barriers to self-injection, by improving self-injection confidence, reducing fear associated with needle use, and supporting patients with impaired dexterity. czp pfp 54-61 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 49-52 32039323-1 2020 A novel composite film of hydroquinone/resorcinol-based poly(arylene ether nitrile) (HQ/RS-PEN) improved by bisphenol A based poly(arylene ether nitrile) (BPA-PEN) was prepared, in which BPA-PEN acts as a plasticizer, leading to improved fluidity of the material, thereby favoring the crystallinity of HQ/RS-PEN. Hydroquinones 26-38 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 91-94 32039323-1 2020 A novel composite film of hydroquinone/resorcinol-based poly(arylene ether nitrile) (HQ/RS-PEN) improved by bisphenol A based poly(arylene ether nitrile) (BPA-PEN) was prepared, in which BPA-PEN acts as a plasticizer, leading to improved fluidity of the material, thereby favoring the crystallinity of HQ/RS-PEN. Hydroquinones 26-38 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 159-162 32039323-1 2020 A novel composite film of hydroquinone/resorcinol-based poly(arylene ether nitrile) (HQ/RS-PEN) improved by bisphenol A based poly(arylene ether nitrile) (BPA-PEN) was prepared, in which BPA-PEN acts as a plasticizer, leading to improved fluidity of the material, thereby favoring the crystallinity of HQ/RS-PEN. Hydroquinones 26-38 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 159-162 32039323-1 2020 A novel composite film of hydroquinone/resorcinol-based poly(arylene ether nitrile) (HQ/RS-PEN) improved by bisphenol A based poly(arylene ether nitrile) (BPA-PEN) was prepared, in which BPA-PEN acts as a plasticizer, leading to improved fluidity of the material, thereby favoring the crystallinity of HQ/RS-PEN. resorcinol 39-49 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 91-94 31646243-0 2019 Carbazole-Anthranyl pi-Conjugates as Small and Stable Aggregation-Induced Emission-Active Fluorogens: Serving as a Reusable and Efficient Platform for Anticounterfeiting Applications with an Acid Key and Multicolor Ink for a Quill Pen. carbazole 0-19 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 231-234 31646243-13 2019 The reversible color-changing behavior on the paper remains intact even after six consecutive days of exposure to sunlight, and the AIEgen is thermally stable up to 445 C. Further, this compound is also utilized as ink (10 muM 1,4-dioxane solution) where a pigeon feather is used as a quill pen. 1,4-dioxane 228-239 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 292-295 31069943-10 2019 RESULTS: Red tinted 2% chlorhexidine gluconate (w/v) with 70% isopropyl alcohol (v/v) was shown to reduce pen mark visibility significantly more than the other solutions used. chlorhexidine gluconate 23-46 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 106-109 31069943-10 2019 RESULTS: Red tinted 2% chlorhexidine gluconate (w/v) with 70% isopropyl alcohol (v/v) was shown to reduce pen mark visibility significantly more than the other solutions used. 2-Propanol 62-79 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 106-109 32039323-1 2020 A novel composite film of hydroquinone/resorcinol-based poly(arylene ether nitrile) (HQ/RS-PEN) improved by bisphenol A based poly(arylene ether nitrile) (BPA-PEN) was prepared, in which BPA-PEN acts as a plasticizer, leading to improved fluidity of the material, thereby favoring the crystallinity of HQ/RS-PEN. resorcinol 39-49 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 159-162 32039323-1 2020 A novel composite film of hydroquinone/resorcinol-based poly(arylene ether nitrile) (HQ/RS-PEN) improved by bisphenol A based poly(arylene ether nitrile) (BPA-PEN) was prepared, in which BPA-PEN acts as a plasticizer, leading to improved fluidity of the material, thereby favoring the crystallinity of HQ/RS-PEN. resorcinol 39-49 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 159-162 32039323-1 2020 A novel composite film of hydroquinone/resorcinol-based poly(arylene ether nitrile) (HQ/RS-PEN) improved by bisphenol A based poly(arylene ether nitrile) (BPA-PEN) was prepared, in which BPA-PEN acts as a plasticizer, leading to improved fluidity of the material, thereby favoring the crystallinity of HQ/RS-PEN. Nitriles 56-83 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 91-94 32039323-1 2020 A novel composite film of hydroquinone/resorcinol-based poly(arylene ether nitrile) (HQ/RS-PEN) improved by bisphenol A based poly(arylene ether nitrile) (BPA-PEN) was prepared, in which BPA-PEN acts as a plasticizer, leading to improved fluidity of the material, thereby favoring the crystallinity of HQ/RS-PEN. Nitriles 56-83 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 159-162 32039323-1 2020 A novel composite film of hydroquinone/resorcinol-based poly(arylene ether nitrile) (HQ/RS-PEN) improved by bisphenol A based poly(arylene ether nitrile) (BPA-PEN) was prepared, in which BPA-PEN acts as a plasticizer, leading to improved fluidity of the material, thereby favoring the crystallinity of HQ/RS-PEN. Nitriles 56-83 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 159-162 32039323-1 2020 A novel composite film of hydroquinone/resorcinol-based poly(arylene ether nitrile) (HQ/RS-PEN) improved by bisphenol A based poly(arylene ether nitrile) (BPA-PEN) was prepared, in which BPA-PEN acts as a plasticizer, leading to improved fluidity of the material, thereby favoring the crystallinity of HQ/RS-PEN. bisphenol A 108-119 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 91-94 32039323-1 2020 A novel composite film of hydroquinone/resorcinol-based poly(arylene ether nitrile) (HQ/RS-PEN) improved by bisphenol A based poly(arylene ether nitrile) (BPA-PEN) was prepared, in which BPA-PEN acts as a plasticizer, leading to improved fluidity of the material, thereby favoring the crystallinity of HQ/RS-PEN. Nitriles 126-153 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 91-94 32039323-1 2020 A novel composite film of hydroquinone/resorcinol-based poly(arylene ether nitrile) (HQ/RS-PEN) improved by bisphenol A based poly(arylene ether nitrile) (BPA-PEN) was prepared, in which BPA-PEN acts as a plasticizer, leading to improved fluidity of the material, thereby favoring the crystallinity of HQ/RS-PEN. Nitriles 126-153 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 159-162 32039323-1 2020 A novel composite film of hydroquinone/resorcinol-based poly(arylene ether nitrile) (HQ/RS-PEN) improved by bisphenol A based poly(arylene ether nitrile) (BPA-PEN) was prepared, in which BPA-PEN acts as a plasticizer, leading to improved fluidity of the material, thereby favoring the crystallinity of HQ/RS-PEN. Nitriles 126-153 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 159-162 32039323-1 2020 A novel composite film of hydroquinone/resorcinol-based poly(arylene ether nitrile) (HQ/RS-PEN) improved by bisphenol A based poly(arylene ether nitrile) (BPA-PEN) was prepared, in which BPA-PEN acts as a plasticizer, leading to improved fluidity of the material, thereby favoring the crystallinity of HQ/RS-PEN. enkephalinamide, Pen(2)-Cys(5)- 88-94 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 159-162 32039323-1 2020 A novel composite film of hydroquinone/resorcinol-based poly(arylene ether nitrile) (HQ/RS-PEN) improved by bisphenol A based poly(arylene ether nitrile) (BPA-PEN) was prepared, in which BPA-PEN acts as a plasticizer, leading to improved fluidity of the material, thereby favoring the crystallinity of HQ/RS-PEN. enkephalinamide, Pen(2)-Cys(5)- 88-94 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 159-162 32039323-3 2020 At the same time, the crystallization of the poly(arylene ether nitrile) blends with 5 wt % BPA-PEN could be promoted under both static and shear flow fields. Nitriles 45-72 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 96-99 32532468-10 2020 Another patient is BAT-positive to Pen G (10.18%, SI=40), Pen V (25.07%, SI=100) and Amp (19.52%, SI=79). Vanadium 62-63 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 58-61 31176152-1 2019 Pentoxyverine citrate (PEN-citrate) is an antitussive (cough suppressant) drug used for cough associated with illnesses like common cold. carbetapentane 0-21 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 23-26 31176152-4 2019 This is the first assay method reported for the quantification of PEN-citrate using the sulfonephthaleins as coloring agents. sulfonephthaleins 88-105 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 66-69 31532622-3 2019 Here, large-area polymer pen lithography is used to pattern substrates with nanoscale extracellular matrix protein features and to identify cues that can be used to direct cytoskeletal organization in human mesenchymal stem cells. Polymers 17-24 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 25-28 31359813-3 2019 All patients received subcutaneous insulin glargine administered by a needle-free injector or a glargine pen for 7 ~ 14 days, and were then crossed over after wash out. Insulin Glargine 96-104 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 105-108 31359813-4 2019 Results: Patients in the insulin needle-free injector (NFI) and glargine pen (GP) groups achieved similar fasting blood glucose control . Insulin Glargine 64-72 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 73-76 31480497-0 2019 Bathyptilones: Terpenoids from an Antarctic Sea Pen, Anthoptilum grandiflorum (Verrill, 1879). bathyptilones 0-13 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 48-51 31412553-2 2019 Herein, boron nitride and polyarylene ether nitrile hybrids (PEN-g-BN) with excellent thermal resistance and thermal conductivity are fabricated. boron nitride 8-21 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 61-64 31461879-1 2019 A novel poly(arylene ether nitrile) terminated with hydroxyl groups (PEN-OH) was synthesized successfully. poly(arylene ether nitrile) 8-35 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 69-72 31461879-1 2019 A novel poly(arylene ether nitrile) terminated with hydroxyl groups (PEN-OH) was synthesized successfully. Hydroxyl Radical 52-60 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 69-72 31461879-3 2019 Due to the cross-linking reaction occurring, at high temperature, among the nitrile groups on the side of the PEN-OH main chain to form a structurally stable triazine ring, the structure of materials changes from a linear structure to a bulk structure. Nitriles 76-83 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 110-113 31461879-3 2019 Due to the cross-linking reaction occurring, at high temperature, among the nitrile groups on the side of the PEN-OH main chain to form a structurally stable triazine ring, the structure of materials changes from a linear structure to a bulk structure. Triazines 158-166 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 110-113 31461879-8 2019 Moreover, because of the excellent adhesive property of PEN-OH to copper foil, a double-layer flexible copper clad laminate (FCCL) without any adhesives based on PEN-OH was prepared by a simple hot-press method, which possessed high peel strength with 1.01 N/mm. Copper 103-109 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 56-59 31412553-2 2019 Herein, boron nitride and polyarylene ether nitrile hybrids (PEN-g-BN) with excellent thermal resistance and thermal conductivity are fabricated. polyarylene ether nitrile 26-51 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 61-64 31412553-4 2019 The obtained BN-CN is introduced to a phthalonitrile end-capped PEN (PEN-Ph) matrix to prepare BN-CN/PEN composites. bn-cn 13-18 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 64-67 31412553-4 2019 The obtained BN-CN is introduced to a phthalonitrile end-capped PEN (PEN-Ph) matrix to prepare BN-CN/PEN composites. bn-cn 13-18 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 69-75 31412553-4 2019 The obtained BN-CN is introduced to a phthalonitrile end-capped PEN (PEN-Ph) matrix to prepare BN-CN/PEN composites. bn-cn 13-18 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 69-72 31412553-4 2019 The obtained BN-CN is introduced to a phthalonitrile end-capped PEN (PEN-Ph) matrix to prepare BN-CN/PEN composites. 1,2-benzenedicarbonitrile 38-52 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 64-67 31412553-4 2019 The obtained BN-CN is introduced to a phthalonitrile end-capped PEN (PEN-Ph) matrix to prepare BN-CN/PEN composites. 1,2-benzenedicarbonitrile 38-52 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 69-75 31412553-4 2019 The obtained BN-CN is introduced to a phthalonitrile end-capped PEN (PEN-Ph) matrix to prepare BN-CN/PEN composites. 1,2-benzenedicarbonitrile 38-52 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 69-72 31412553-4 2019 The obtained BN-CN is introduced to a phthalonitrile end-capped PEN (PEN-Ph) matrix to prepare BN-CN/PEN composites. bn-cn 95-100 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 64-67 31412553-4 2019 The obtained BN-CN is introduced to a phthalonitrile end-capped PEN (PEN-Ph) matrix to prepare BN-CN/PEN composites. bn-cn 95-100 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 69-75 31412553-4 2019 The obtained BN-CN is introduced to a phthalonitrile end-capped PEN (PEN-Ph) matrix to prepare BN-CN/PEN composites. bn-cn 95-100 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 69-72 31096642-0 2019 Writing Behavior of Phospholipids in Polymer Pen Lithography (PPL) for Bioactive Micropatterns. Phospholipids 20-33 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 45-48 31336901-1 2019 Enhanced dielectric and mechanical properties of polyarylene ether nitrile (PEN) are obtained through secondary dispersion of polyaniline functionalized barium titanate (PANI-f-BT) by hot-stretching. polyarylene ether nitrile 49-74 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 76-79 31336901-1 2019 Enhanced dielectric and mechanical properties of polyarylene ether nitrile (PEN) are obtained through secondary dispersion of polyaniline functionalized barium titanate (PANI-f-BT) by hot-stretching. polyaniline 126-137 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 76-79 31336901-1 2019 Enhanced dielectric and mechanical properties of polyarylene ether nitrile (PEN) are obtained through secondary dispersion of polyaniline functionalized barium titanate (PANI-f-BT) by hot-stretching. barium titanate(IV) 153-168 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 76-79 31336901-1 2019 Enhanced dielectric and mechanical properties of polyarylene ether nitrile (PEN) are obtained through secondary dispersion of polyaniline functionalized barium titanate (PANI-f-BT) by hot-stretching. pani-f-bt 170-179 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 76-79 31336901-4 2019 These nanoparticles are used as functional fillers to compound with PEN (PEN/PANI-f-BT) for studying its effect on the mechanical and dielectric performance of the obtained composites. pani-f-bt 77-86 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 68-71 31336901-6 2019 The results exhibit that the PANI-f-BT nanoparticles present good compatibility and dispersion in the PEN matrix, and the hot-stretching endows the second dispersion of PANI-f-BT in PEN resulting in enhanced mechanical properties, crystallinity and permittivity-temperature stability of the nanocomposites. pani-f-bt 29-38 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 102-105 31336901-6 2019 The results exhibit that the PANI-f-BT nanoparticles present good compatibility and dispersion in the PEN matrix, and the hot-stretching endows the second dispersion of PANI-f-BT in PEN resulting in enhanced mechanical properties, crystallinity and permittivity-temperature stability of the nanocomposites. pani-f-bt 169-178 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 182-185 31362450-2 2019 Here, we report a facile protocol to fabricate an immunosensor supported by a thermally resistant flexible polymer substrate (polyarylene ether nitrile, PEN). Polymers 107-114 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 153-156 30950141-1 2019 In this study, via a simple one-step method, chiral copper sulfide quantum dots (d/l-QDs) were prepared using d-/l-penicillamine (d-/l-Pen). cupric sulfide 52-66 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 135-138 30950141-1 2019 In this study, via a simple one-step method, chiral copper sulfide quantum dots (d/l-QDs) were prepared using d-/l-penicillamine (d-/l-Pen). d-/l-penicillamine 110-128 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 135-138 30933479-7 2019 We found mutating the metal binding amino acids to l-Pen can enforce trigonal Cd(II)S3 geometry exclusively compared to the mixed coordination determined for l-Cys coordination. Metals 22-27 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 53-56 30933479-7 2019 We found mutating the metal binding amino acids to l-Pen can enforce trigonal Cd(II)S3 geometry exclusively compared to the mixed coordination determined for l-Cys coordination. cd(ii) 78-84 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 53-56 30874423-4 2019 6,13-Bis(triisopropylsilylethynyl)pentacene (TIPS-PEN) crystal patterns are grown on the line-shaped wetting regions of the patterned film, and the crystallinity of TIPS-PEN and alignment of molecules are found using various crystal analysis tools depending on the pattern widths. TIPS-pentacene 0-43 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 50-53 30857829-1 2019 The goal of this study is to explore the mechanism of a heat shock protein 90 (Hsp90) C-terminal inhibitor, Penicisulfuranol A (PEN-A), for cancer therapy. Penicisulfuranol A 108-126 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 128-131 30857829-2 2019 PEN-A was produced by a mangrove endophytic fungus Penicillium janthinellum and had a new structure with a rare 3H-spiro [benzofuran-2, 2"-piperazine] ring system. 3h-spiro 112-120 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 0-3 30857829-2 2019 PEN-A was produced by a mangrove endophytic fungus Penicillium janthinellum and had a new structure with a rare 3H-spiro [benzofuran-2, 2"-piperazine] ring system. benzofuran-2, 2"-piperazine 122-149 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 0-3 30857829-5 2019 Mechanism studies showed that PEN-A was bound to C-terminus of Hsp90 at the binding site different from ATP binding domain. Adenosine Triphosphate 104-107 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 30-33 30857829-7 2019 These inhibitory effects of PEN-A were similar to those of novobiocin, an inhibitor binding to interaction site for ATP of C-terminus of Hsp90. Adenosine Triphosphate 116-119 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 28-31 30857829-8 2019 Furthermore, our study revealed that disulfide bond was essential moiety for inhibition activity of PEN-A on Hsp90. Disulfides 37-46 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 100-103 30857829-9 2019 This suggested that PEN-A may be bound to cysteine residues near amino acid region which was responsible for dimerization of Hsp90. Cysteine 42-50 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 20-23 30824071-0 2019 Ultrafine and carboxylated beta-chitin nanofibers prepared from squid pen and its transparent hydrogels. beta-chitin 27-38 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 70-73 30824071-3 2019 It might be due to the existence of the small amount of partial deacetylation (DD 9%) in the squid pen beta-chitins. beta-chitins 105-117 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 101-104 30824071-5 2019 When 45 wt% APS was used to react with squid pen, the carboxylate content of ChNFs reaches 0.802 mmol/g. carboxylate 54-65 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 45-48 30770374-3 2019 We have developed a handheld and biocompatible device coupled to a mass spectrometer, the MasSpec Pen, which uses a discrete water droplet for molecular extraction and rapid tissue diagnosis. Water 125-130 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 98-101 30680763-2 2019 In this study, penicillamine-protected gold nanoclusters (Pen-AuNCs) were synthesized and initially fractionated by sequential size-selective precipitation (SSSP). Penicillamine 15-28 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 58-61 30874423-4 2019 6,13-Bis(triisopropylsilylethynyl)pentacene (TIPS-PEN) crystal patterns are grown on the line-shaped wetting regions of the patterned film, and the crystallinity of TIPS-PEN and alignment of molecules are found using various crystal analysis tools depending on the pattern widths. TIPS-pentacene 0-43 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 170-173 30768077-3 2019 The application of this carbon on ITO/PEN substrates is also demonstrated. Carbon 24-30 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 38-41 30735385-0 2019 Discovery of an SSTR2-Targeting Maytansinoid Conjugate (PEN-221) with Potent Activity in Vitro and in Vivo. Maytansinoid 32-44 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 56-59 30735385-3 2019 Herein, we describe our efforts towards an efficacious SSTR2-targeting cytotoxic conjugate; examination of different SSTR2-targeting ligands, conjugation sites, and payloads led to the discovery of 22 (PEN-221), a conjugate consisting of microtubule-targeting agent DM1 linked to the C-terminal side chain of Tyr3-octreotate. octreotate, Tyr(3)- 309-324 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 202-205 30996778-6 2019 administration, higher than that of the cyclic biphalin analogues containing a disulfide bridge between the side chains of two d-Cys or d-Pen residues, previously described by our group. cyclic biphalin 40-55 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 138-141 30081589-6 2018 The effects of the various surface morphologies on the crystallization behavior of crystallizable poly(arylene ether nitrile) (c-PEN) were first employed to confirm the surface characteristics of the resulted microspheres. poly(arylene ether nitrile) 98-125 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 129-132 30755646-3 2019 By applying an additional dye such as Coumarin 307, or simply a highlighter pen, the emission line can be shifted from blue (~440 nm), towards turquoise (>480 nm), up to orange (590 nm) which can be useful for spectroscopic applications. coumarin 38-46 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 76-79 29883754-12 2019 These data provide proof of concept for a guideline-based selection of patients labeled with Pen-A for a direct penicillin challenge. Penicillins 112-122 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 93-96 30684268-18 2019 Chitin from squid pen could be further converted to chitosan with high DDA. Chitin 0-6 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 18-21 30684268-18 2019 Chitin from squid pen could be further converted to chitosan with high DDA. Chitosan 52-60 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 18-21 30684268-18 2019 Chitin from squid pen could be further converted to chitosan with high DDA. dda 71-74 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 18-21 30723504-7 2019 On the basis of combined results of UV-VIS, TLC, and FTIR, the DP was found from 0.73-0.8 for blue, 0.80-1.0 for black, 0.5-1.0 for green, and 1.0 for red colored fountain pen inks. dp 63-65 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 172-175 30455865-4 2018 The determination of specific IgE antibodies was positive for Pen m 4, a sarcoplasmic calcium binding protein, with a level of 6.7 ISU-E. Calcium 86-93 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 62-65 30081589-7 2018 Results indicated that the etched Fe3O4/FePc microspheres would improve the crystallization degree of c-PEN, due to their much more micro/mesoporous structures than that of original Fe3O4/FePc. ferryl iron 34-39 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 104-107 30081589-7 2018 Results indicated that the etched Fe3O4/FePc microspheres would improve the crystallization degree of c-PEN, due to their much more micro/mesoporous structures than that of original Fe3O4/FePc. Iron(II) phthalocyanine 40-44 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 104-107 30081589-8 2018 Then, Fe3O4/FePc hybrid microspheres reinforced PEN composite films were prepared and their interfacial compatibility was monitored using an SEM. ferryl iron 6-11 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 48-51 29956908-0 2018 Tuning of the Topochemical Polymerization of Diacetylenes Based on an Odd/Even Effect of the Peripheral Alkyl Chain: Thermochromic Reversibility in a Thin Film and a Single-Component Ink for a Fountain Pen. diacetylenes 45-57 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 202-205 30093848-1 2018 Background: Pen-based devices have emerged as useful tools for measuring pH and glucose, and for fabricating microchannels and microarrays. Glucose 80-87 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 12-15 29386311-10 2018 CONCLUSION: Patients with EGC with tumors >2 cm, Pen A-type disease according to Kodama, or lymph node metastases show a poorer prognosis and an increased risk of cancer-specific mortality. (-)-Epigallocatechin 26-29 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 52-55 29985313-5 2018 This protocol describes the utilization of polymer pen lithography to produce nanometer-scale features over centimeter-sized areas, facilitated by the use of an algorithm for the rapid, accurate, and automated alignment of probe arrays. Polymers 43-50 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 51-54 29952107-1 2018 Dip-pen nanolithography (DPN) is used to precisely position core/thick-shell ("giant") quantum dots (gQDs; >=10 nm in diameter) exclusively on top of silicon nanodisk antennas ( 500 nm diameter pillars with a height of 200 nm), resulting in periodic arrays of hybrid nanostructures and demonstrating a facile integration strategy toward next-generation quantum light sources. dpn 25-28 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 29686042-3 2018 Thus, the present study aims to elucidate the membrane- and metabolism-associated effects of l-Penetratin (l-PEN) and its corresponding all-d analog (d-PEN). penetratin 93-105 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 109-112 30966674-1 2018 A novel phthalonitrile-terminated polyaryl ether nitrile (PEN-Ph) was synthesized and characterized. 1,2-benzenedicarbonitrile 8-22 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 58-61 30966674-1 2018 A novel phthalonitrile-terminated polyaryl ether nitrile (PEN-Ph) was synthesized and characterized. polyaryl ether nitrile 34-56 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 58-61 30966674-7 2018 This suggests that the activation energy of the crystallization behavior is lower than that of the crosslinking behavior, indicating that the crystallization behavior is more likely to occur than the crosslinking behavior and the crystals of PEN-Ph can be self-crosslinked to form single-polymer composites. Polymers 288-295 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 242-245 29686042-3 2018 Thus, the present study aims to elucidate the membrane- and metabolism-associated effects of l-Penetratin (l-PEN) and its corresponding all-d analog (d-PEN). penetratin 93-105 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 152-155 29575578-0 2018 Direct-Patterning SWCNTs Using Dip Pen Nanolithography for SWCNT/Silicon Solar Cells. 3,5-diisopropylsalicylic acid 31-34 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 35-38 29575578-1 2018 Dip pen nanolithography (DPN) is used to pattern single-walled carbon nanotube (SWCNT) lines between the n-type Si and SWCNT film in SWCNT/Si solar cells. 3,5-diisopropylsalicylic acid 0-3 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 29575578-1 2018 Dip pen nanolithography (DPN) is used to pattern single-walled carbon nanotube (SWCNT) lines between the n-type Si and SWCNT film in SWCNT/Si solar cells. dpn 25-28 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 29575578-1 2018 Dip pen nanolithography (DPN) is used to pattern single-walled carbon nanotube (SWCNT) lines between the n-type Si and SWCNT film in SWCNT/Si solar cells. Carbon 63-69 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 29575578-1 2018 Dip pen nanolithography (DPN) is used to pattern single-walled carbon nanotube (SWCNT) lines between the n-type Si and SWCNT film in SWCNT/Si solar cells. Silicon 112-114 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 29575578-1 2018 Dip pen nanolithography (DPN) is used to pattern single-walled carbon nanotube (SWCNT) lines between the n-type Si and SWCNT film in SWCNT/Si solar cells. Silicon 139-141 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 29320187-6 2018 The dispersion energy contributions to BEs in PEn-Au-PEn rise nearly linearly with the number of carbon atoms in the PEn chain. BES 39-42 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 46-49 29320187-6 2018 The dispersion energy contributions to BEs in PEn-Au-PEn rise nearly linearly with the number of carbon atoms in the PEn chain. BES 39-42 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 53-56 29320187-6 2018 The dispersion energy contributions to BEs in PEn-Au-PEn rise nearly linearly with the number of carbon atoms in the PEn chain. BES 39-42 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 53-56 29320187-6 2018 The dispersion energy contributions to BEs in PEn-Au-PEn rise nearly linearly with the number of carbon atoms in the PEn chain. Carbon 97-103 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 46-49 29320187-6 2018 The dispersion energy contributions to BEs in PEn-Au-PEn rise nearly linearly with the number of carbon atoms in the PEn chain. Carbon 97-103 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 53-56 29320187-6 2018 The dispersion energy contributions to BEs in PEn-Au-PEn rise nearly linearly with the number of carbon atoms in the PEn chain. Carbon 97-103 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 53-56 29323220-1 2018 Large-area, pinhole-free CH3NH3PbI3 perovskite thin films were successfully fabricated on 5 cm x 5 cm flexible indium tin oxide coated polyethylene naphthalate (ITO-PEN) substrates through a sequential evaporation/spin-coating deposition method in this research. ch3nh3pbi3 perovskite 25-46 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 165-168 29382898-2 2018 The developed PTX loaded Mn:ZnS NPs with different CPPs (PEN, pVEC and R9) showed enhanced anti-cancer effect compared to bare PTX, which has been validated by MTT assay followed by apoptosis assay and DNA fragmentation analysis. Paclitaxel 14-17 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 57-60 30965898-5 2017 In addition, the cyano (-CN) groups of functional layer also can serve as potential sites for cross-linking with polyarylene ether nitrile terminated phthalonitrile (PEN-Ph) matrix and make it transform from thermoplastic to thermosetting. polyarylene ether nitrile 113-138 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 166-169 29376785-9 2018 Red pen should be avoided with betadine skin preparation. Povidone-Iodine 31-39 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 29348106-6 2018 In this piece of work the effect of salt and complexes of Palladium on the status of different thiols (GSH, NAC, and D-Pen) in aqueous medium, were examined, The thiol quantification was carried out using Elman"s method through UV-visible spectrophotometry and 1H- NMR. Salts 36-40 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 119-122 29416197-2 2017 Goal: To determine the optimal insulin delivery method for the prevention of hypoglycemia recorded by continuous monitoring of glucose in patients with insulin pump and PEN. Glucose 127-134 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 169-172 29399427-1 2017 A 16-year-old male presented to the emergency department with chest pain after smoking a synthetic cannabinoid from a vape pen. Cannabinoids 99-110 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 123-126 28082323-0 2018 Second Generation Electronic Nicotine Delivery System Vape Pen Exposure Generalizes as a Smoking Cue. Nicotine 29-37 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 59-62 29130281-0 2017 An unusual failure of sevoflurane QuikFil PEN bottles. Sevoflurane 22-33 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 42-45 29245263-4 2017 A 53-year-old man who had a history of iron wire ingestion went to our hospital, on examination, he only had slight abdominal tenderness due to swallowing a ball pen and 1 cap nut 1 day before, radiological imaging showed penetrating renal trauma, the blood test showed his renal function is normal. Iron 39-43 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 162-165 28756318-2 2017 Versatile counter electrodes using this carbon sphere catalyst on different substrates of fluorine-doped tin oxide (FTO) glass, indium-doped tin oxide polyethylenena phthalate (ITO-PEN), and Ti foil are fabricated for dye-sensitized solar cell (DSC). Carbon 40-46 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 181-184 28756318-4 2017 With cobalt electrolyte, the DSC using carbon sphere counter electrodes based on FTO glass, ITO-PEN, and Ti substrates yield high power conversion efficiency values of 8.57%, 6.66%, and 9.10%, respectively. Cobalt 5-11 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 96-99 28756318-4 2017 With cobalt electrolyte, the DSC using carbon sphere counter electrodes based on FTO glass, ITO-PEN, and Ti substrates yield high power conversion efficiency values of 8.57%, 6.66%, and 9.10%, respectively. Carbon 39-45 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 96-99 30965898-5 2017 In addition, the cyano (-CN) groups of functional layer also can serve as potential sites for cross-linking with polyarylene ether nitrile terminated phthalonitrile (PEN-Ph) matrix and make it transform from thermoplastic to thermosetting. 1,2-benzenedicarbonitrile 150-164 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 166-169 30965898-6 2017 Comparing with the pure PEN-ph film, the latter results indicated that the formation of cross-linked network in the polymer-based system resulted in increased tensile strength by ~67%, improved glass transition temperature (Tg) by ~190 C. More importantly, the CPEN/F-BaTiO3 composite films filled with 30 wt % F-BaTiO3 particles showed greater energy density by nearly 190% when compared to pure CPEN film. Polymers 116-123 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 24-27 28832124-3 2017 Herein, as a positive test case for chiral alloy nanoparticle synthesis, the stable and large chiroptical ultrafine Au-Ag alloy NPs were prepared by reduction of different molar fractions of HAuCl4 and AgNO3 with NaBH4 in the presence of d/l-penicillamine (d/l-Pen). Deuterium 86-87 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 261-264 28941181-0 2017 Large-Area Patterning of Metal Nanostructures by Dip-Pen Nanodisplacement Lithography for Optical Applications. Metals 25-30 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 53-56 28858643-0 2017 Exploring putative inhibitors of Death Associated Protein Kinase 1 (DAPK1) via targeting Gly-Glu-Leu (GEL) and Pro-Glu-Asn (PEN) substrate recognition motifs. Pro-Glu-Asn 111-122 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 124-127 28858643-6 2017 This inhibitor was found potent and considerably selective to DAPK1 as it made direct contact with the ATP binding sites as well as substrate recognition motifs: Gly-Glu-Leu (GEL) and Pro-Glu-Asn (PEN). Pro-Glu-Asn 184-195 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 197-200 28878011-3 2017 The device, named MasSpec Pen, enables controlled and automated delivery of a discrete water droplet to a tissue surface for efficient extraction of biomolecules. Water 87-92 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 26-29 28822344-2 2017 It reviews those ink aging methods that are based on the analysis (measurement) of ink solvents (e.g., 2-phenoxyethanol, which is the most common among ballpoint pen inks). phenoxyethanol 103-119 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 162-165 28650173-0 2017 Polymer Pen Lithography with Lipids for Large-Area Gradient Patterns. Polymers 0-7 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 8-11 28650173-2 2017 Polymer pen lithography (PPL) as an inherent highly parallel and large area technique has a great potential to serve in the fabrication of such patterns. Polymers 0-7 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 8-11 28650173-6 2017 By increasing the force applied to the elastomeric pens, which increases the tip-surface contact area and boosts the ink delivery rate, a switch between a dip-pen nanolithography (DPN) and a microcontact printing (muCP) transfer mode can be induced. dpn 180-183 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 51-54 28734603-1 2017 Some harmful volatile organic compounds (VOCs), such as methylbenzene, ethylbenzene, xylene, chlorobenzene and bromobenzene, are the commonly found chemicals in pen inks. Toluene 56-69 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 161-164 28734603-1 2017 Some harmful volatile organic compounds (VOCs), such as methylbenzene, ethylbenzene, xylene, chlorobenzene and bromobenzene, are the commonly found chemicals in pen inks. ethylbenzene 57-69 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 161-164 28734603-1 2017 Some harmful volatile organic compounds (VOCs), such as methylbenzene, ethylbenzene, xylene, chlorobenzene and bromobenzene, are the commonly found chemicals in pen inks. Xylenes 85-91 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 161-164 28734603-1 2017 Some harmful volatile organic compounds (VOCs), such as methylbenzene, ethylbenzene, xylene, chlorobenzene and bromobenzene, are the commonly found chemicals in pen inks. chlorobenzene 93-106 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 161-164 28734603-1 2017 Some harmful volatile organic compounds (VOCs), such as methylbenzene, ethylbenzene, xylene, chlorobenzene and bromobenzene, are the commonly found chemicals in pen inks. bromobenzene 111-123 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 161-164 28734603-2 2017 In this work, a dynamic headspace needle-trap device (D-HS-NTD) with a ZIF-8-derived nanoporous carbon (ZIF-8-NPC) as the adsorbent was developed for the extraction of some VOCs in different pen inks prior to GC-MS detection. 2-Methylimidazole zinc salt 71-76 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 191-194 28783949-12 2017 Furthermore, we fabricated an array of flexible TMB-processed PDPP2DT-F2T2 FETs on the plastic PEN substrates. pseudocumene 48-51 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 95-98 28811154-1 2017 By Means of Marcus electron transfer theory, the charge transport properties of tetraazapentacene (4N-PEN) derivatives were systematically explored. tetraazapentacene 80-97 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 102-105 30971018-7 2017 The glass transition temperature, relative permittivity, and tensile strength of CPEN/GS-Zn-CNT with 2.0 wt % GS-Zn-CNT, compared to that of PEN, were increased by 18%, 181%, and 27%, respectively. zn-cnt 89-95 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 82-85 30971018-4 2017 Phthalonitrile end-capped polyarylene ether nitrile (PEN-Ph) permeated into the GO-Zn-CNT in N-methyl-2-pyrrolidone (NMP) and the corresponding composite PEN/GO-Zn-CNT was fabricated through the solution-casting method. 1,2-benzenedicarbonitrile 0-14 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 53-56 30971018-4 2017 Phthalonitrile end-capped polyarylene ether nitrile (PEN-Ph) permeated into the GO-Zn-CNT in N-methyl-2-pyrrolidone (NMP) and the corresponding composite PEN/GO-Zn-CNT was fabricated through the solution-casting method. 1,2-benzenedicarbonitrile 0-14 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 154-157 28773199-6 2017 We also successfully fabricated high-performance flexible mixed lead halide perovskite solar cells based on PEN substrates. halide 69-75 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 108-111 30971018-4 2017 Phthalonitrile end-capped polyarylene ether nitrile (PEN-Ph) permeated into the GO-Zn-CNT in N-methyl-2-pyrrolidone (NMP) and the corresponding composite PEN/GO-Zn-CNT was fabricated through the solution-casting method. polyarylene ether nitrile 26-51 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 53-56 30971018-4 2017 Phthalonitrile end-capped polyarylene ether nitrile (PEN-Ph) permeated into the GO-Zn-CNT in N-methyl-2-pyrrolidone (NMP) and the corresponding composite PEN/GO-Zn-CNT was fabricated through the solution-casting method. polyarylene ether nitrile 26-51 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 154-157 30971018-4 2017 Phthalonitrile end-capped polyarylene ether nitrile (PEN-Ph) permeated into the GO-Zn-CNT in N-methyl-2-pyrrolidone (NMP) and the corresponding composite PEN/GO-Zn-CNT was fabricated through the solution-casting method. go-zn-cnt 80-89 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 53-56 30971018-4 2017 Phthalonitrile end-capped polyarylene ether nitrile (PEN-Ph) permeated into the GO-Zn-CNT in N-methyl-2-pyrrolidone (NMP) and the corresponding composite PEN/GO-Zn-CNT was fabricated through the solution-casting method. go-zn-cnt 80-89 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 154-157 30971018-4 2017 Phthalonitrile end-capped polyarylene ether nitrile (PEN-Ph) permeated into the GO-Zn-CNT in N-methyl-2-pyrrolidone (NMP) and the corresponding composite PEN/GO-Zn-CNT was fabricated through the solution-casting method. N-methylpyrrolidone 93-115 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 53-56 30971018-4 2017 Phthalonitrile end-capped polyarylene ether nitrile (PEN-Ph) permeated into the GO-Zn-CNT in N-methyl-2-pyrrolidone (NMP) and the corresponding composite PEN/GO-Zn-CNT was fabricated through the solution-casting method. N-methylpyrrolidone 93-115 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 154-157 30971018-4 2017 Phthalonitrile end-capped polyarylene ether nitrile (PEN-Ph) permeated into the GO-Zn-CNT in N-methyl-2-pyrrolidone (NMP) and the corresponding composite PEN/GO-Zn-CNT was fabricated through the solution-casting method. N-methylpyrrolidone 117-120 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 53-56 30971018-4 2017 Phthalonitrile end-capped polyarylene ether nitrile (PEN-Ph) permeated into the GO-Zn-CNT in N-methyl-2-pyrrolidone (NMP) and the corresponding composite PEN/GO-Zn-CNT was fabricated through the solution-casting method. N-methylpyrrolidone 117-120 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 154-157 30971018-4 2017 Phthalonitrile end-capped polyarylene ether nitrile (PEN-Ph) permeated into the GO-Zn-CNT in N-methyl-2-pyrrolidone (NMP) and the corresponding composite PEN/GO-Zn-CNT was fabricated through the solution-casting method. go-zn-cnt 158-167 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 53-56 30971018-4 2017 Phthalonitrile end-capped polyarylene ether nitrile (PEN-Ph) permeated into the GO-Zn-CNT in N-methyl-2-pyrrolidone (NMP) and the corresponding composite PEN/GO-Zn-CNT was fabricated through the solution-casting method. go-zn-cnt 158-167 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 154-157 28773199-6 2017 We also successfully fabricated high-performance flexible mixed lead halide perovskite solar cells based on PEN substrates. perovskite 76-86 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 108-111 28287703-0 2017 High Throughput Synthesis of Multifunctional Oxide Nanostructures within Nanoreactors Defined by Beam Pen Lithography. Oxides 45-50 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 102-105 28296390-0 2017 Clickable Antifouling Polymer Brushes for Polymer Pen Lithography. Polymers 22-29 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 50-53 28409640-4 2017 Associated simulations revealed a nanometer-scale quadratic relationship between contact line widths of the polymer pens and two other variables: polymer-pen base line widths and vertical compression distances. Polymers 108-115 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 116-119 28409640-4 2017 Associated simulations revealed a nanometer-scale quadratic relationship between contact line widths of the polymer pens and two other variables: polymer-pen base line widths and vertical compression distances. Polymers 146-153 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 116-119 28230283-1 2017 The benchmark of soluble organic semiconductors based on acenes is the 6,13-bis(triisopropylsilylethynyl)pentacene (TIPS-PEN). anthracene 57-63 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 121-124 28230283-1 2017 The benchmark of soluble organic semiconductors based on acenes is the 6,13-bis(triisopropylsilylethynyl)pentacene (TIPS-PEN). TIPS-pentacene 71-114 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 121-124 28230283-4 2017 Herein, we present an efficient synthesis and characterization of bistetracene derivatives that exhibit a band gap up to 1.71 eV and an increased stability up to 21 times compared to TIPS-PEN and mobility over 0.1 cm2 V-1 s-1 in solution-processed organic field-effect transistors. bistetracene 66-78 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 188-191 28492664-0 2017 Size-tunable, highly sensitive microelectrode arrays enabled by polymer pen lithography. Polymers 64-71 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 72-75 28492664-1 2017 By combining polymer pen lithography (PPL) patterning with in situ polymerization, we report a straightforward and bottom-up approach for bench-top fabrication of microelectrode arrays (MEAs) with well-controlled dimensions. Polymers 13-20 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 21-24 28296390-0 2017 Clickable Antifouling Polymer Brushes for Polymer Pen Lithography. Polymers 42-49 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 50-53 28296390-5 2017 The protein-repellent polymer brush is functionalized by highly localized molecular binding sites in the low micrometer range using polymer pen lithography (PPL). Polymers 22-29 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 140-143 28032754-5 2017 The formation of organic TIPS-PEN semiconductor microwire and their electrical properties were optimized by controlling both the amounts of added insulating polymer and the widths of the microwires. Polymers 157-164 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 30-33 28117961-0 2017 Flexible Fiber-Shaped Supercapacitor Based on Nickel-Cobalt Double Hydroxide and Pen Ink Electrodes on Metallized Carbon Fiber. Carbon 114-120 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 81-84 28117961-4 2017 Subsequently, the commercially available conductive pen ink modified high conductive composite fibers, on which uniformly covered ultrathin nickel-cobalt double hydroxides (Ni-Co DHs) were introduced to fabricate flexible FSSCs. ultrathin nickel-cobalt double hydroxides 130-171 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 52-55 28117961-4 2017 Subsequently, the commercially available conductive pen ink modified high conductive composite fibers, on which uniformly covered ultrathin nickel-cobalt double hydroxides (Ni-Co DHs) were introduced to fabricate flexible FSSCs. ni-co 173-178 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 52-55 28240854-0 2017 Correction to Thermoresponsive Polymer Micropatterns Fabricated by Dip-Pen Nanolithography for a Highly Controllable Substrate with Potential Cellular Applications. Polymers 31-38 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 71-74 30460315-1 2017 Abstract: By means of inkjet printing technique, flexible and all-solid-state micro-supercapacitors (MSCs) were fabricated with carbon-based hybrid ink composed of graphene oxide (GO, 98.0 vol.%) ink and commercial pen ink (2.0 vol.%). Carbon 128-134 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 215-218 28106171-3 2017 Wax-patterned paper microzones created in this way are utilized to conduct the pen-type pH meter-based P-ELISAs with enzyme-loaded SiO2 microbeads for highly efficient signal amplification of each antibody-antigen binding event. Silicon Dioxide 131-135 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 79-82 28337397-2 2017 Using a small calligraphy-brush-style synthetic hair pen (nylon-brush), and analogous to paper-spray mass spectrometry, the analytes can be collected, elution/desorption and then ionized from the surface of the nylon-brush. Nylons 58-63 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 53-56 30460315-2 2017 A small amount of commercial pen ink was added to effectively reduce the agglomeration of the GO sheets during solvent evaporation and the following reduction processes in which the presence of graphite carbon nanoparticles served as nano-spacer to separate GO sheets. Carbon 203-209 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 29-32 27941231-1 2017 Copper (Cu) films and circuits were fabricated by screen-printing Cu nanoink on low-Tg (glass transition temperature) flexible plastic substrates (PEN and PET) instead of widely used high-Tg polyimide (PI) substrate. Copper 0-6 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 147-150 27941231-1 2017 Copper (Cu) films and circuits were fabricated by screen-printing Cu nanoink on low-Tg (glass transition temperature) flexible plastic substrates (PEN and PET) instead of widely used high-Tg polyimide (PI) substrate. Copper 8-10 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 147-150 27941231-4 2017 The sintered Cu films exhibited strong adhesion to PEN and PET substrates, with measured adhesion strength of 5B by the ASTM D3359 international standard, whereas the top part of the copper film on the PI substrate was stripped off during the adhesion test. Copper 13-15 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 51-54 30460315-2 2017 A small amount of commercial pen ink was added to effectively reduce the agglomeration of the GO sheets during solvent evaporation and the following reduction processes in which the presence of graphite carbon nanoparticles served as nano-spacer to separate GO sheets. Graphite 194-202 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 29-32 28725704-7 2016 The transdermal rotigotine patch, infusion therapies with apomorphine, intrajejunal levodopa, and the apomorphine pen strategy are currently in clinical use with a few others in development. Apomorphine 102-113 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 114-117 28049320-1 2016 Pentacene (C22H14, PEN) and perfluoropentacene (C22F14, PFP) are considered promising building blocks of organic semiconductors. pentacene 0-9 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 19-22 27827436-2 2016 The film is obtained by solution-casting of polyarylene ether nitrile terminated phthalonitrile (PEN-Ph) combined with post self-crosslinking at high temperature. polyarylene ether nitrile 44-69 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 97-100 27827436-2 2016 The film is obtained by solution-casting of polyarylene ether nitrile terminated phthalonitrile (PEN-Ph) combined with post self-crosslinking at high temperature. 1,2-benzenedicarbonitrile 81-95 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 97-100 27505180-8 2016 The multifunctional characteristics of the microchemical pen are confirmed by different types of reactions in many research areas, including inorganic chemistry, polymer science, electrochemistry and biological sample treatment. Polymers 162-169 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 57-60 27683974-9 2016 Synergistic cytotoxic activity was seen between BEN and dADO/PEN suggesting that the combination of BEN and PEN should be evaluated in the clinic. 2-Deoxyadenosine 56-60 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 108-111 27494423-1 2016 Phospholipid membranes of different functionalities were simultaneously assembled on arrays of graphene surfaces in a parallel manner using multi-pen lipid dip-pen nano-lithography. Phospholipids 0-12 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 146-149 27511293-0 2016 Click-Chemistry Based Allergen Arrays Generated by Polymer Pen Lithography for Mast Cell Activation Studies. Polymers 51-58 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 59-62 27511293-4 2016 Here, a click-chemistry approach is applied in combination with polymer pen lithography (PPL) to pattern DNP-azide on alkyne-terminated surfaces to generate arrays of allergen. dnp-azide 105-114 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 72-75 27511293-4 2016 Here, a click-chemistry approach is applied in combination with polymer pen lithography (PPL) to pattern DNP-azide on alkyne-terminated surfaces to generate arrays of allergen. Alkynes 118-124 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 72-75 27572916-0 2016 Thermoresponsive Polymer Micropatterns Fabricated by Dip-Pen Nanolithography for a Highly Controllable Substrate with Potential Cellular Applications. Polymers 17-24 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 57-60 27572916-1 2016 We report a novel approach for patterning thermoresponsive hydrogels based on N,N-diethylacrylamide (DEAAm) and bifunctional Jeffamine ED-600 by dip-pen nanolithography (DPN). N,N-Diethylacrylamide 78-99 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 149-152 27572916-1 2016 We report a novel approach for patterning thermoresponsive hydrogels based on N,N-diethylacrylamide (DEAAm) and bifunctional Jeffamine ED-600 by dip-pen nanolithography (DPN). deaam 101-106 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 149-152 27572916-1 2016 We report a novel approach for patterning thermoresponsive hydrogels based on N,N-diethylacrylamide (DEAAm) and bifunctional Jeffamine ED-600 by dip-pen nanolithography (DPN). JEFFAMINE 125-134 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 149-152 27572916-1 2016 We report a novel approach for patterning thermoresponsive hydrogels based on N,N-diethylacrylamide (DEAAm) and bifunctional Jeffamine ED-600 by dip-pen nanolithography (DPN). ed-600 135-141 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 149-152 27185957-6 2016 There was an increased risk of NMSC in patients taking CSA (RR = 2.51, 95% CI: 1.23, 5.13) and D-Pen (RR 3.49, 95% CI: 1.34, 4.63) in addition to MTX, but not for patients taking AZA or LEF. Azathioprine 179-182 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 97-100 27185957-6 2016 There was an increased risk of NMSC in patients taking CSA (RR = 2.51, 95% CI: 1.23, 5.13) and D-Pen (RR 3.49, 95% CI: 1.34, 4.63) in addition to MTX, but not for patients taking AZA or LEF. lef 186-189 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 97-100 27711347-0 2016 Multi-color polymer pen lithography for oligonucleotide arrays. Polymers 12-19 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 20-23 27711347-0 2016 Multi-color polymer pen lithography for oligonucleotide arrays. Oligonucleotides 40-55 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 20-23 27711347-1 2016 Multi-color patterning by polymer pen lithography (PPL) was used to fabricate covalently immobilized fluorophore and oligonucleotide arrays with up to five different components. Oligonucleotides 117-132 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 34-37 27494348-4 2016 The optimised method was applied to the analysis of 11 water-based pen inks and the determination of their metal composition. Water 55-60 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 67-70 27572916-1 2016 We report a novel approach for patterning thermoresponsive hydrogels based on N,N-diethylacrylamide (DEAAm) and bifunctional Jeffamine ED-600 by dip-pen nanolithography (DPN). dpn 170-173 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 149-152 27581663-0 2016 Epinephrine pen maker offers discounts after alleged price hiking. Epinephrine 0-11 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 12-15 27494423-1 2016 Phospholipid membranes of different functionalities were simultaneously assembled on arrays of graphene surfaces in a parallel manner using multi-pen lipid dip-pen nano-lithography. Phospholipids 0-12 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 160-163 27494423-1 2016 Phospholipid membranes of different functionalities were simultaneously assembled on arrays of graphene surfaces in a parallel manner using multi-pen lipid dip-pen nano-lithography. Graphite 95-103 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 146-149 27494423-1 2016 Phospholipid membranes of different functionalities were simultaneously assembled on arrays of graphene surfaces in a parallel manner using multi-pen lipid dip-pen nano-lithography. Graphite 95-103 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 160-163 27027319-5 2016 On the basis of halogen substitution, the substitution of terminal benzene ring of triisopropyl-silylethynyl-pentacene (TIPS-PEN) by a thiophene or pyridine will greatly lower the LUMO level and improve the stacking mode, leading to more suitable ambipolar materials. Halogens 16-23 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 125-128 27427585-1 2016 N-isopropylacrylamide modified PEI (PEN) was synthesized via Michael addition and was developed as an efficient siRNA delivery system both in vitro and in vivo. N-isopropylacrylamide 0-21 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 36-39 27027319-5 2016 On the basis of halogen substitution, the substitution of terminal benzene ring of triisopropyl-silylethynyl-pentacene (TIPS-PEN) by a thiophene or pyridine will greatly lower the LUMO level and improve the stacking mode, leading to more suitable ambipolar materials. Benzene 67-74 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 125-128 27027319-5 2016 On the basis of halogen substitution, the substitution of terminal benzene ring of triisopropyl-silylethynyl-pentacene (TIPS-PEN) by a thiophene or pyridine will greatly lower the LUMO level and improve the stacking mode, leading to more suitable ambipolar materials. Thiophenes 135-144 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 125-128 27027319-5 2016 On the basis of halogen substitution, the substitution of terminal benzene ring of triisopropyl-silylethynyl-pentacene (TIPS-PEN) by a thiophene or pyridine will greatly lower the LUMO level and improve the stacking mode, leading to more suitable ambipolar materials. pyridine 148-156 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 125-128 26928012-0 2016 Hard Transparent Arrays for Polymer Pen Lithography. Polymers 28-35 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 36-39 26928012-3 2016 Here, we show that by coating polymer pen arrays with a ~175 nm silica layer, the resulting hard transparent arrays exhibit a force-independent contact area that improves their patterning capability by reducing the minimum feature size (~40 nm), minimum feature pitch (<200 nm for polymers), and pen to pen variation. Polymers 30-37 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 38-41 26958704-5 2016 NiOx-based flexible perovskite solar cells were fabricated on ITO-PEN substrates, and a preliminary PCE of 13.43% was achieved. niox 0-4 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 66-69 26928012-3 2016 Here, we show that by coating polymer pen arrays with a ~175 nm silica layer, the resulting hard transparent arrays exhibit a force-independent contact area that improves their patterning capability by reducing the minimum feature size (~40 nm), minimum feature pitch (<200 nm for polymers), and pen to pen variation. Polymers 30-37 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 136-139 26928012-3 2016 Here, we show that by coating polymer pen arrays with a ~175 nm silica layer, the resulting hard transparent arrays exhibit a force-independent contact area that improves their patterning capability by reducing the minimum feature size (~40 nm), minimum feature pitch (<200 nm for polymers), and pen to pen variation. Polymers 30-37 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 136-139 26928012-3 2016 Here, we show that by coating polymer pen arrays with a ~175 nm silica layer, the resulting hard transparent arrays exhibit a force-independent contact area that improves their patterning capability by reducing the minimum feature size (~40 nm), minimum feature pitch (<200 nm for polymers), and pen to pen variation. Silicon Dioxide 64-70 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 38-41 26928012-3 2016 Here, we show that by coating polymer pen arrays with a ~175 nm silica layer, the resulting hard transparent arrays exhibit a force-independent contact area that improves their patterning capability by reducing the minimum feature size (~40 nm), minimum feature pitch (<200 nm for polymers), and pen to pen variation. Silicon Dioxide 64-70 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 136-139 26928012-3 2016 Here, we show that by coating polymer pen arrays with a ~175 nm silica layer, the resulting hard transparent arrays exhibit a force-independent contact area that improves their patterning capability by reducing the minimum feature size (~40 nm), minimum feature pitch (<200 nm for polymers), and pen to pen variation. Silicon Dioxide 64-70 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 136-139 26928012-3 2016 Here, we show that by coating polymer pen arrays with a ~175 nm silica layer, the resulting hard transparent arrays exhibit a force-independent contact area that improves their patterning capability by reducing the minimum feature size (~40 nm), minimum feature pitch (<200 nm for polymers), and pen to pen variation. Polymers 284-292 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 38-41 26928012-3 2016 Here, we show that by coating polymer pen arrays with a ~175 nm silica layer, the resulting hard transparent arrays exhibit a force-independent contact area that improves their patterning capability by reducing the minimum feature size (~40 nm), minimum feature pitch (<200 nm for polymers), and pen to pen variation. Polymers 284-292 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 136-139 26928012-3 2016 Here, we show that by coating polymer pen arrays with a ~175 nm silica layer, the resulting hard transparent arrays exhibit a force-independent contact area that improves their patterning capability by reducing the minimum feature size (~40 nm), minimum feature pitch (<200 nm for polymers), and pen to pen variation. Polymers 284-292 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 136-139 26928012-6 2016 Ultimately, this form of polymer pen lithography allows for patterning with the resolution of dip-pen nanolithography across centimeter scales using simple and inexpensive pen arrays. Polymers 25-32 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 33-36 26928012-6 2016 Ultimately, this form of polymer pen lithography allows for patterning with the resolution of dip-pen nanolithography across centimeter scales using simple and inexpensive pen arrays. Polymers 25-32 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 98-101 26928012-6 2016 Ultimately, this form of polymer pen lithography allows for patterning with the resolution of dip-pen nanolithography across centimeter scales using simple and inexpensive pen arrays. Polymers 25-32 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 98-101 26882128-2 2016 This work was designed to investigate the recognition and binding of three typical beta-lactam antibiotics including penicillin G (Pen G), penicillin V (Pen V) and cefalexin (Cef) with bovine serum albumin (BSA) by frontal affinity chromatography in combination with UV-vis absorption spectra, fluorescence emission spectra, binding site marker competitive experiment and molecular docking under simulated physiological conditions. beta-Lactams 83-94 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 131-134 26882128-2 2016 This work was designed to investigate the recognition and binding of three typical beta-lactam antibiotics including penicillin G (Pen G), penicillin V (Pen V) and cefalexin (Cef) with bovine serum albumin (BSA) by frontal affinity chromatography in combination with UV-vis absorption spectra, fluorescence emission spectra, binding site marker competitive experiment and molecular docking under simulated physiological conditions. Penicillin G 117-129 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 131-134 26882128-2 2016 This work was designed to investigate the recognition and binding of three typical beta-lactam antibiotics including penicillin G (Pen G), penicillin V (Pen V) and cefalexin (Cef) with bovine serum albumin (BSA) by frontal affinity chromatography in combination with UV-vis absorption spectra, fluorescence emission spectra, binding site marker competitive experiment and molecular docking under simulated physiological conditions. Penicillin V 139-151 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 153-156 26214056-14 2015 For Ei = 5 eV, the pen-phys-pen, pen-phys, phys-pen, and phys trapping mechanisms have similar probabilities. phys 23-27 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 19-22 26572435-1 2016 We previously reported a chitin nanofiber hydrogel from squid pen beta-chitin by a simple NaOH treatment. beta-chitin 66-77 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 62-65 26572435-1 2016 We previously reported a chitin nanofiber hydrogel from squid pen beta-chitin by a simple NaOH treatment. Sodium Hydroxide 90-94 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 62-65 26624508-0 2016 Direct Pen Writing of Adhesive Particle-Free Ultrahigh Silver Salt-Loaded Composite Ink for Stretchable Circuits. Sodium 2-anthraquinonesulfonate 55-66 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 7-10 26713357-9 2016 Radio frequency inductors, which are highly sensitive to metal quality, were demonstrated as a proof of concept on flexible PEN substrate. Metals 57-62 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 124-127 26354252-0 2015 Adsorption mechanisms of L-Glutathione on Au and controlled nano-patterning through Dip Pen Nanolithography. Glutathione 25-38 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 88-91 26354252-1 2015 Dip Pen Nanolithography technique has been employed for patterning L-Glutathione tripeptide (l-y-glutamyl-l-cysteinyl-glycine) nanostructures at specific locations on metallic Au(111) substrate. 3,5-diisopropylsalicylic acid 0-3 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 26354252-1 2015 Dip Pen Nanolithography technique has been employed for patterning L-Glutathione tripeptide (l-y-glutamyl-l-cysteinyl-glycine) nanostructures at specific locations on metallic Au(111) substrate. Glutathione 67-80 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 26354252-1 2015 Dip Pen Nanolithography technique has been employed for patterning L-Glutathione tripeptide (l-y-glutamyl-l-cysteinyl-glycine) nanostructures at specific locations on metallic Au(111) substrate. tripeptide K-26 81-91 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 26354252-1 2015 Dip Pen Nanolithography technique has been employed for patterning L-Glutathione tripeptide (l-y-glutamyl-l-cysteinyl-glycine) nanostructures at specific locations on metallic Au(111) substrate. l-y-glutamyl-l-cysteinyl-glycine 93-125 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 26354252-1 2015 Dip Pen Nanolithography technique has been employed for patterning L-Glutathione tripeptide (l-y-glutamyl-l-cysteinyl-glycine) nanostructures at specific locations on metallic Au(111) substrate. Gold 176-178 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 26693078-4 2015 To address these limitations, we developed PhyloPen, an experimental novel multi-touch and pen application that renders a phylogenetic tree and allows users to interactively navigate within the tree, examining nodes, branches, and auxiliary information, and annotate the tree for note-taking and collaboration. phylopen 43-51 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 91-94 26214056-14 2015 For Ei = 5 eV, the pen-phys-pen, pen-phys, phys-pen, and phys trapping mechanisms have similar probabilities. phys 23-27 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 28-31 26214056-14 2015 For Ei = 5 eV, the pen-phys-pen, pen-phys, phys-pen, and phys trapping mechanisms have similar probabilities. phys 23-27 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 28-31 26214056-14 2015 For Ei = 5 eV, the pen-phys-pen, pen-phys, phys-pen, and phys trapping mechanisms have similar probabilities. phys 23-27 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 28-31 26257849-9 2015 The international normalized ratio of prothrombin time (P < 0.001) and the activated partial thromboplastin time (P < 0.001) were significantly prolonged in Group-PEN compared to those of Group-TETB. 5,5,7,12,12,14-hexamethyl-1,4,8,11-tetrazacyclotetradecane 200-204 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 169-172 26179027-7 2015 However, DAPNe-NSI-MS successfully discerned that the pen was dispensed on different days by quantitating the oxidation process. dapne 9-14 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 54-57 25990887-4 2015 Therefore, the overall aim of this study was to investigate if increased pig and pen soiling increases skatole concentration in entire male pigs. Skatole 103-110 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 81-84 25990887-10 2015 Moreover, outdoor pen soiling significantly affected skatole concentration in interactions with herd and season (P<0.001 and P=0.003) and affected human nose positive risk in interaction with herd (P=0.005). Skatole 53-60 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 18-21 26827544-1 2015 OBJECTIVE: To investigate the inhibition effect of curcumin on the proliferation of the human esophageal carcinoma cell line Ec109 and its impact on PEN/PI3K/Akt signaling pathway. Curcumin 51-59 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 149-152 26081390-3 2015 Here, polymer pen lithography is demonstrated with a novel leveling method to account for the magnitude and direction of the total applied force of tip arrays by a multipoint force sensing structure integrated into the tip holder. Polymers 6-13 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 14-17 25856496-9 2015 Absorbance decreased over 2 hours when marking pen was mixed with 1:1000 epinephrine (0.82 AU 0.32 AU) and lido+epi (1.19 AU 0.33 AU). lido+epi 109-117 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 47-50 26245285-10 2015 The second case involves a 22-year-old woman, a psychiatric hospital resident, presenting to the accident and emergency department 5 h after deliberately inserting the metal nib and inner plastic ink containing tube of a pen through her umbilicus. metal nib 168-177 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 221-224 25288693-14 2015 A hydrocortisone pen would hold a great potential to lower the current barriers to hydrocortisone self-injection. Hydrocortisone 2-16 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 17-20 25759181-0 2015 Evaluation of the Dual-Chamber Pen Design for the Injection of Exenatide Once Weekly for the Treatment of Type 2 Diabetes. Exenatide 63-72 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 31-34 25974155-0 2015 Direct Pen Writing of High-Tc, Flexible Magnesium Diboride Superconducting Arrays. magnesium boride 40-58 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 7-10 25984650-3 2015 It was shown that (3-mercaptopropyl)trimethoxysilane SALs enable significant adhesion improvements for both aqueous- and organic-based silver inks, approaching nearly 100% for PEN and PDMS substrates while exhibiting relatively low sheet resistance up to 0.1 Omega/sq. (3-mercaptopropyl)trimethoxysilane 18-52 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 176-179 26083646-1 2015 Incorporating spin-polarized scanning tunneling microscopy (SP-STM) measurements and first-principles calculations, we resolve spin-polarized states and consequent features in a pentacene(PEN)-Co hybrid system. pentacene 178-187 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 188-191 25288693-14 2015 A hydrocortisone pen would hold a great potential to lower the current barriers to hydrocortisone self-injection. Hydrocortisone 83-97 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 17-20 25742438-6 2015 The combination of the IR capture laser and the ultraviolet (UV) cutting laser is used to isolate individual dopamine neurons or the ventral tegmental area when using PEN membrane slides. Dopamine 109-117 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 167-170 25904773-5 2015 RESULTS: At the end of 12 months, effluent dialysate levels of CA125, decorin, HGF, IL-6, adiponectin and adhesion molecules were significantly higher in the PEN group compared to controls, but all decreased after patients switched to glucose-based PDF. Glucose 235-242 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 158-161 25904773-9 2015 Dialysate-to-plasma creatinine ratio at 4 h was higher in the PEN group at 12 months and remained so after switching to glucose-based PDF. Creatinine 20-30 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 62-65 25476521-2 2015 However, plastic substrates such as PEN and PET are permeable to water, oxygen and volatile electrolyte solvents, which is detrimental to the cell stability. Water 65-70 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 36-39 25476521-2 2015 However, plastic substrates such as PEN and PET are permeable to water, oxygen and volatile electrolyte solvents, which is detrimental to the cell stability. Oxygen 72-78 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 36-39 25653059-1 2015 Penicillin G (Pen-G) biosensor was developed by immobilizing penicillinase enzymes (Pen-X) onto tiny bio-chips using thioglycolic acid self-assembled monolayer (TGA-SAM). 2-mercaptoacetate 117-134 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 14-17 25256006-0 2015 Construction of 3D polymer brushes by dip-pen nanodisplacement lithography: understanding the molecular displacement for ultrafine and high-speed patterning. Polymers 19-26 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 42-45 25256006-1 2015 Dip-pen nanodisplacement lithography (DNL) is a versatile scanning probe-based technique that can be employed for fabricating ultrafine 3D polymer brushes under ambient conditions. Polymers 139-146 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 25653059-1 2015 Penicillin G (Pen-G) biosensor was developed by immobilizing penicillinase enzymes (Pen-X) onto tiny bio-chips using thioglycolic acid self-assembled monolayer (TGA-SAM). Penicillin G 0-12 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 14-17 25653059-1 2015 Penicillin G (Pen-G) biosensor was developed by immobilizing penicillinase enzymes (Pen-X) onto tiny bio-chips using thioglycolic acid self-assembled monolayer (TGA-SAM). 2-mercaptoacetate 117-134 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 0-3 25653059-2 2015 The selective pen-G biosensor was investigated by ferri/ferrocyanide couple using electrochemical method for catalytic hydrolysis of Pen-G/Pen-X in a very sensible approach. ferri/ferrocyanide 50-68 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 14-17 25653059-2 2015 The selective pen-G biosensor was investigated by ferri/ferrocyanide couple using electrochemical method for catalytic hydrolysis of Pen-G/Pen-X in a very sensible approach. ferri/ferrocyanide 50-68 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 133-136 25653059-2 2015 The selective pen-G biosensor was investigated by ferri/ferrocyanide couple using electrochemical method for catalytic hydrolysis of Pen-G/Pen-X in a very sensible approach. ferri/ferrocyanide 50-68 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 139-142 25450547-0 2015 Effect of water-soluble chitosan in combination with glutathione on the quality of pen shell adductor muscles. Water 10-15 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 83-86 25385465-1 2014 A spectroscopic investigation of the complexes formed between the Pb(II) ion and D-penicillamine (H2Pen), a chelating agent used in the treatment of lead poisoning, was carried out on two sets of alkaline aqueous solutions with CPb(II) 10 and 100 mM, varying the H2Pen/Pb(II) molar ratio (2.0, 3.0, 4.0, 10.0). pb(ii) 66-72 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 100-103 28989393-2 2015 The adenosine triphosphate (ATP) bioluminescence assay is an easy-to-perform, on-the-spot assay that provides objective data; therefore, using the LuciPac Pen and the Lumitester PD-20 System, we assessed contamination of the working environment of anaesthetists before and after surgery as well as their hands at the time of each procedure during induction and extubation. Adenosine Triphosphate 4-26 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 155-158 25385465-1 2014 A spectroscopic investigation of the complexes formed between the Pb(II) ion and D-penicillamine (H2Pen), a chelating agent used in the treatment of lead poisoning, was carried out on two sets of alkaline aqueous solutions with CPb(II) 10 and 100 mM, varying the H2Pen/Pb(II) molar ratio (2.0, 3.0, 4.0, 10.0). Penicillamine 81-96 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 100-103 25385465-1 2014 A spectroscopic investigation of the complexes formed between the Pb(II) ion and D-penicillamine (H2Pen), a chelating agent used in the treatment of lead poisoning, was carried out on two sets of alkaline aqueous solutions with CPb(II) 10 and 100 mM, varying the H2Pen/Pb(II) molar ratio (2.0, 3.0, 4.0, 10.0). Lead 66-68 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 100-103 25385465-7 2014 The combined spectroscopic results, reporting delta((207)Pb) 1870 ppm and lambdamax 298 nm for a Pb(II)S2NO site, are consistent with a dominating 1:2 lead(II):penicillamine complex with [Pb(S,N,O-Pen)(S-HnPen)](2-n) (n = 0-1) coordination in alkaline solutions, and provide useful structural information on how penicillamine can function as an antidote against lead toxicity in vivo. Penicillamine 164-177 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 201-204 25628687-9 2014 The bond strength of RelyX Unicem was significantly higher to Silano-Pen treated Verabond (P=0.011). verabond 81-89 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 69-72 25039825-2 2014 A working solution of a water/glycerol emulsion and butylene glycol is applied to thermal paper by means of either a vinyl stamp and pad, or a marker pen. Water 24-29 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 150-153 25039825-2 2014 A working solution of a water/glycerol emulsion and butylene glycol is applied to thermal paper by means of either a vinyl stamp and pad, or a marker pen. 1,3-butylene glycol 52-67 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 150-153 25367043-1 2014 The charge-transport properties of a series of silylethynylated N-heteropentacenes (TIPS-PEN-xN; x = 2, 4) were systematically investigated using Marcus electron-transfer theory coupled with kinetic Monte Carlo simulations. n-heteropentacenes 64-82 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 89-92 25367043-5 2014 Transport parameters evaluated from the hopping and band-like models both demonstrate that, among the TIPS-PEN-xN molecules, B-TIPS-PEN-4N-which has two internal pyrazine rings-is the most promising n-type material. Pyrazines 162-170 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 132-135 23922294-2 2014 Graphene is "written" from typical graphene oxide dispersion by applying negative potential on conductive surfaces vs. a micrometer-sized counter electrode "pen" with scanning electrochemical microscopy (SECM). Graphite 0-8 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 157-160 24789330-8 2014 This approach should bring SERS closer to the real world through ink cartridges to be fixed to a pen to create plasmonic sensors at will. sers 27-31 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 97-100 24417672-0 2014 Massively parallel patterning of complex 2D and 3D functional polymer brushes by polymer pen lithography. Polymers 62-69 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 89-92 24417672-1 2014 We report the first demonstration of centimeter-area serial patterning of complex 2D and 3D functional polymer brushes by high-throughput polymer pen lithography. Polymers 103-110 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 146-149 24417672-1 2014 We report the first demonstration of centimeter-area serial patterning of complex 2D and 3D functional polymer brushes by high-throughput polymer pen lithography. Polymers 138-145 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 146-149 24813164-0 2014 Inclusion complexes of beta-cyclodextrin-dinitrocompounds as UV absorber for ballpoint pen ink. betadex 23-40 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 87-90 24789330-2 2014 Inspired by recent advances in conductive ink pens for electronic devices on paper, we present a "pen-on-paper" approach for making surface enhanced Raman scattering (SERS) substrates. sers 167-171 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 46-49 24789330-3 2014 Through this approach, no professional training is required to create SERS arrays on paper using an ordinary fountain pen filled with plasmonic inks comprising metal nanoparticles of arbitrary shape and size. sers 70-74 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 118-121 24983446-0 2014 Subcutaneous administration of methotrexate with a prefilled autoinjector pen results in a higher relative bioavailability compared with oral administration of methotrexate. Methotrexate 31-43 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 74-77 25125973-6 2014 RESULTS: Overall patient preference for the MTX prefilled pen was 75% (P<0.0001). Methotrexate 44-47 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 58-61 25125973-10 2014 As well, 92% of physicians and study nurses indicated that they would recommend the MTX prefilled pen to patients for future MTX treatment. Methotrexate 84-87 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 98-101 25125973-10 2014 As well, 92% of physicians and study nurses indicated that they would recommend the MTX prefilled pen to patients for future MTX treatment. Methotrexate 125-128 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 98-101 25125973-12 2014 CONCLUSION: SC self-injection of MTX with a prefilled pen was generally preferred, by patients with RA, over a prefilled syringe with regard to use, acceptability, and satisfaction. Methotrexate 33-36 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 54-57 24983446-8 2014 RESULTS: Bioavailability, as measured by maximum plasma concentrations (Cmax) and area under the plasma-concentration curves (AUC0-t), was generally higher with the SC MTX pen compared with oral administration for all dose groups. Methotrexate 168-171 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 172-175 24983446-13 2014 CONCLUSIONS: Single-dose administration with the SC MTX pen resulted in a higher relative bioavailability compared with oral administration. Methotrexate 52-55 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 56-59 24983446-14 2014 SC MTX pen administration was associated with fewer gastrointestinal AEs than oral MTX. Methotrexate 3-6 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 7-10 24326004-12 2014 CONCLUSION: Patients switching to a glargine pen device achieved lower HbA1c at the 6-month follow-up. Insulin Glargine 36-44 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 45-48 25017533-2 2014 However, the commercially available benzylpenicilloyl polylysine (Pre-Pen) is not indicated in the pediatric population. penicilloyl polylysine 36-64 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 70-73 24684470-1 2014 Recently 1-(phenylethynyl)naphthalene (1-PEN) was suggested to be the primary dimerization product of phenylpropargyl radicals and therefore an important polycyclic hydrocarbon in combustion processes. 1-(Phenylethynyl)naphthalene 9-37 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 41-44 24515547-1 2014 Alginate hydrogels functionalized with D-, or L-penicillamine (D-, L-PEN-Alg) are used as new 3D scaffolds for cell adhesion studies. Alginates 0-8 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 69-72 24515547-1 2014 Alginate hydrogels functionalized with D-, or L-penicillamine (D-, L-PEN-Alg) are used as new 3D scaffolds for cell adhesion studies. d-, or l-penicillamine 39-61 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 69-72 24515547-3 2014 C-6-glioma and endothelial cells show higher affinity to the D-PEN than to the L-PEN functionalized 3D alginate hydrogel scaffold. Alginates 103-111 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 81-84 24943704-0 2014 A novel treatment for subacute thyroiditis: administration of a mixture of lidocaine and dexamethasone using an insulin pen. Lidocaine 75-84 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 120-123 24766067-1 2014 New tripodal metal-chelating agents derived from nitrilotriacetic acid (NTA) and extended by three unnatural amino acids D-penicillamine (D-Pen) are presented. tripodal 4-12 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 140-143 24766067-1 2014 New tripodal metal-chelating agents derived from nitrilotriacetic acid (NTA) and extended by three unnatural amino acids D-penicillamine (D-Pen) are presented. Metals 13-18 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 140-143 24766067-1 2014 New tripodal metal-chelating agents derived from nitrilotriacetic acid (NTA) and extended by three unnatural amino acids D-penicillamine (D-Pen) are presented. Penicillamine 121-136 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 140-143 24766067-2 2014 D-Pen is actually the drug most extensively used to treat copper (Cu) overload in Wilson"s disease and as such is a very attractive building block for the design of chelating agents. Copper 58-64 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 2-5 24766067-2 2014 D-Pen is actually the drug most extensively used to treat copper (Cu) overload in Wilson"s disease and as such is a very attractive building block for the design of chelating agents. Copper 66-68 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 2-5 24766067-3 2014 D-Pen is also a bulkier analogue of cysteine, with the beta-methylene hydrogen atoms replaced by larger methyl groups. Cysteine 36-44 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 2-5 24766067-3 2014 D-Pen is also a bulkier analogue of cysteine, with the beta-methylene hydrogen atoms replaced by larger methyl groups. beta-methylene hydrogen 55-78 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 2-5 24766067-5 2014 The ligands L(4) (ester) and L(5) (amide) were obtained from NTA and commercial D-Pen synthons in four and five steps with overall yields of 14 and 24%, respectively. l(4) ( 12-18 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 82-85 24766067-5 2014 The ligands L(4) (ester) and L(5) (amide) were obtained from NTA and commercial D-Pen synthons in four and five steps with overall yields of 14 and 24%, respectively. l(5) (amide 29-40 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 82-85 24684470-1 2014 Recently 1-(phenylethynyl)naphthalene (1-PEN) was suggested to be the primary dimerization product of phenylpropargyl radicals and therefore an important polycyclic hydrocarbon in combustion processes. phenylpropargyl radicals 102-126 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 41-44 24684470-1 2014 Recently 1-(phenylethynyl)naphthalene (1-PEN) was suggested to be the primary dimerization product of phenylpropargyl radicals and therefore an important polycyclic hydrocarbon in combustion processes. Hydrocarbons 165-176 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 41-44 24748824-7 2014 In all, 67.2% found the new somatropin disposable pen to be no different from or easier to use than the reusable pen (95% confidence interval: 58.8-75.7). Human Growth Hormone 28-38 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 50-53 25343298-7 2014 High levels of ethylbenzene were detected in permanent pen (ND-345,065 ppm), shoe polish (ND-277,928 ppm), leather cleaner (42,223 ppm), whiteout (ND-2,770 ppm), and glue (ND-792 ppm). ethylbenzene 15-27 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 55-58 24309996-2 2014 Herein, we utilize small molecules such as ethylene glycol (EG) or glycerol to facilitate the delivery of nanoparticle precursors to the substrates in the polymer pen lithography (PPL) process. Ethylene Glycol 43-58 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 163-166 24309996-2 2014 Herein, we utilize small molecules such as ethylene glycol (EG) or glycerol to facilitate the delivery of nanoparticle precursors to the substrates in the polymer pen lithography (PPL) process. Ethylene Glycol 60-62 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 163-166 24309996-2 2014 Herein, we utilize small molecules such as ethylene glycol (EG) or glycerol to facilitate the delivery of nanoparticle precursors to the substrates in the polymer pen lithography (PPL) process. Glycerol 67-75 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 163-166 24883171-4 2014 The gas-phase concentration of n-butanol at the tip of each pen was measured directly in a new set of pens via proton-transfer-reaction mass spectrometry (PTR-MS). 1-Butanol 31-40 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 60-63 24876551-3 2014 Using a large database of US retirees, this retrospective longitudinal study examined 1-year follow-up outcomes in patients with T2DM aged 65 years or older who were either insulin naive and initiated insulin glargine via disposable pen (pen initiators [PI]) or vial (vial initiators [VI]) or were already insulin glargine users but either continued with a vial (vial continuers [VC]) or switched to a disposable pen (pen switchers [PS]). Insulin Glargine 209-217 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 238-241 24876551-3 2014 Using a large database of US retirees, this retrospective longitudinal study examined 1-year follow-up outcomes in patients with T2DM aged 65 years or older who were either insulin naive and initiated insulin glargine via disposable pen (pen initiators [PI]) or vial (vial initiators [VI]) or were already insulin glargine users but either continued with a vial (vial continuers [VC]) or switched to a disposable pen (pen switchers [PS]). Insulin Glargine 209-217 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 238-241 24876551-3 2014 Using a large database of US retirees, this retrospective longitudinal study examined 1-year follow-up outcomes in patients with T2DM aged 65 years or older who were either insulin naive and initiated insulin glargine via disposable pen (pen initiators [PI]) or vial (vial initiators [VI]) or were already insulin glargine users but either continued with a vial (vial continuers [VC]) or switched to a disposable pen (pen switchers [PS]). Insulin Glargine 209-217 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 238-241 24876551-8 2014 In elderly patients with T2DM receiving insulin glargine therapy, initiating or switching to a disposable pen was associated with better treatment persistence and adherence than initiating or continuing with vial-and-syringe, without increased total health care costs. Insulin Glargine 48-56 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 106-109 24876551-9 2014 Among insulin-naive patients, initiating insulin glargine by disposable pen was also associated with significantly reduced risk of hypoglycemia compared with vial-and-syringe patients. Insulin Glargine 49-57 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 72-75 24470402-0 2014 Growth of long triisopropylsilylethynyl pentacene (TIPS-PEN) nanofibrils in a polymer thin film during spin-coating. triisopropylsilylethynyl pentacene 15-49 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 56-59 24470402-0 2014 Growth of long triisopropylsilylethynyl pentacene (TIPS-PEN) nanofibrils in a polymer thin film during spin-coating. Polymers 78-85 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 56-59 24470402-1 2014 This study demonstrates the growth of long triisopropylsilyethynyl pentacene (TIPS-PEN) nanofibrils in a thin film of a crystalline polymer, poly(epsilon-caprolactone) (PCL). triisopropylsilyethynyl pentacene 43-76 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 83-86 24470402-1 2014 This study demonstrates the growth of long triisopropylsilyethynyl pentacene (TIPS-PEN) nanofibrils in a thin film of a crystalline polymer, poly(epsilon-caprolactone) (PCL). Polymers 132-139 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 83-86 24470402-1 2014 This study demonstrates the growth of long triisopropylsilyethynyl pentacene (TIPS-PEN) nanofibrils in a thin film of a crystalline polymer, poly(epsilon-caprolactone) (PCL). polycaprolactone 141-167 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 83-86 24470402-1 2014 This study demonstrates the growth of long triisopropylsilyethynyl pentacene (TIPS-PEN) nanofibrils in a thin film of a crystalline polymer, poly(epsilon-caprolactone) (PCL). polycaprolactone 169-172 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 83-86 25343298-8 2014 Xylene was detected in permanent pen (ND-285,132 ppm), shoe polish (ND-87,298 ppm), leather cleaner (12,266 ppm), glue (ND-3,124 ppm), and whiteout (ND-1,400 ppm). Xylenes 0-6 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 33-36 24320821-3 2013 We also explored the patterning of the hydrophilic polymer polyethylene glycol (PEG) and found that, even though PDMS only absorbs trace amounts of water, soaking a PDMS pen array in water enables PEG deposition in completely dry environments for over 2 h. We find that the length of time one can pattern in a dry environment is determined by the availability of absorbed solvent, a relationship that we elucidate by comparing the performance of pens with varying ability to absorb water. Polyethylene Glycols 59-78 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 170-173 24320821-3 2013 We also explored the patterning of the hydrophilic polymer polyethylene glycol (PEG) and found that, even though PDMS only absorbs trace amounts of water, soaking a PDMS pen array in water enables PEG deposition in completely dry environments for over 2 h. We find that the length of time one can pattern in a dry environment is determined by the availability of absorbed solvent, a relationship that we elucidate by comparing the performance of pens with varying ability to absorb water. Polyethylene Glycols 80-83 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 170-173 24320821-3 2013 We also explored the patterning of the hydrophilic polymer polyethylene glycol (PEG) and found that, even though PDMS only absorbs trace amounts of water, soaking a PDMS pen array in water enables PEG deposition in completely dry environments for over 2 h. We find that the length of time one can pattern in a dry environment is determined by the availability of absorbed solvent, a relationship that we elucidate by comparing the performance of pens with varying ability to absorb water. Water 148-153 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 170-173 24320821-3 2013 We also explored the patterning of the hydrophilic polymer polyethylene glycol (PEG) and found that, even though PDMS only absorbs trace amounts of water, soaking a PDMS pen array in water enables PEG deposition in completely dry environments for over 2 h. We find that the length of time one can pattern in a dry environment is determined by the availability of absorbed solvent, a relationship that we elucidate by comparing the performance of pens with varying ability to absorb water. Water 183-188 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 170-173 24320821-3 2013 We also explored the patterning of the hydrophilic polymer polyethylene glycol (PEG) and found that, even though PDMS only absorbs trace amounts of water, soaking a PDMS pen array in water enables PEG deposition in completely dry environments for over 2 h. We find that the length of time one can pattern in a dry environment is determined by the availability of absorbed solvent, a relationship that we elucidate by comparing the performance of pens with varying ability to absorb water. Polyethylene Glycols 197-200 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 170-173 24320821-3 2013 We also explored the patterning of the hydrophilic polymer polyethylene glycol (PEG) and found that, even though PDMS only absorbs trace amounts of water, soaking a PDMS pen array in water enables PEG deposition in completely dry environments for over 2 h. We find that the length of time one can pattern in a dry environment is determined by the availability of absorbed solvent, a relationship that we elucidate by comparing the performance of pens with varying ability to absorb water. Water 183-188 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 170-173 23554307-3 2013 Here, a new integrative approach is presented for the fabrication of bioactive microarrays and complex multi-ink patterns by polymer pen lithography (PPL). Polymers 125-132 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 133-136 24263094-0 2013 Large-area molecular patterning with polymer pen lithography. Polymers 37-44 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 45-48 24263094-2 2013 This protocol describes the steps required for performing molecular printing using polymer pen lithography (PPL), a cantilever-free scanning probe-based technique that can generate sub-100-nm molecular features in a massively parallel fashion. Polymers 83-90 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 91-94 24282570-3 2013 In this contribution, by patterning adhesive PEG (polyethylene glycol) hydrogels using Dip Pen Nanolithography (DPN), we demonstrate that substrate elasticity, subcellular elasticity, ligand density, and topography ultimately define mesenchymal stem cells (MSCs) spreading and shape. Polyethylene Glycols 45-48 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 91-94 24282570-3 2013 In this contribution, by patterning adhesive PEG (polyethylene glycol) hydrogels using Dip Pen Nanolithography (DPN), we demonstrate that substrate elasticity, subcellular elasticity, ligand density, and topography ultimately define mesenchymal stem cells (MSCs) spreading and shape. Polyethylene Glycols 50-69 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 91-94 24203164-8 2013 Of the THR patients, 81.8% (95% confidence interval (CI) 78.4 to 84.7) preferred pen-and-paper questionnaires to electronic questionnaires, as did 86.8% (95% CI 83.1 to 89.8) of TKR patients. Threonine 7-10 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 81-84 24203164-11 2013 CONCLUSIONS: The majority of THR and TKR patients prefer pen-and-paper questionnaires. Threonine 29-32 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 57-60 24042582-3 2013 In the bending and tape tests, PEDOT-carbon composite catalyst layers exhibited higher elasticity and better adhesion on all the studied substrates (ITO-PET and ITO-PEN plastic, and FTO-glass), compared to a binder free carbon composite and a TiO2 binder enriched carbon composite, and showed lower charge transfer resistance (1.5-3 Omega cm(2)) than the traditional thermally platinized CE (5 Omega cm(2)), demonstrating better catalytic performance for the tri-iodide reduction reaction. Carbon 37-43 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 165-168 24042582-4 2013 Also the TiO2 binder enriched carbon composite showed good catalytic characteristics and relatively good adhesion on ITO-PET, but on ITO-PEN its adhesion was poor. Carbon 30-36 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 137-140 23177979-6 2013 Recently Pre Pen has been FDA re-approved and when combined with Pen G is a valid way to determine if patients are able to tolerate beta-lactam antibiotic. beta-Lactams 132-143 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 13-16 23992481-2 2013 Our approach is based on a fountain pen probe with appropriate dimensions enabling reversible filling with (nonwetting) mercury under changing the applied pressure at a connected mercury supply in a dedicated experimental setup. Mercury 120-127 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 36-39 23992481-2 2013 Our approach is based on a fountain pen probe with appropriate dimensions enabling reversible filling with (nonwetting) mercury under changing the applied pressure at a connected mercury supply in a dedicated experimental setup. Mercury 179-186 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 36-39 23992481-7 2013 Finally, cyclic voltammetry and square wave voltammetry were done in a static mercury electrode fountain pen configuration, demonstrating the principle usability of the mercury probe for electrochemical studies. Mercury 169-176 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 105-108 23177979-6 2013 Recently Pre Pen has been FDA re-approved and when combined with Pen G is a valid way to determine if patients are able to tolerate beta-lactam antibiotic. beta-Lactams 132-143 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 65-68 23646879-1 2013 Resistance switching memory devices with the configuration of poly(ethylene naphthalate)(PEN)/Al/polyimide (PI) blend/Al are reported. poly(ethylene naphthalate) 62-88 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 89-92 23612355-3 2013 Firstly, a pentapeptide-polyethylene glycol2000-stearate was synthesized and formulated into Pen-NLCs. pentapeptide-polyethylene glycol2000-stearate 11-56 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 93-96 23612355-8 2013 Through intravenous administration, a single dose of DXM loaded Pen-NLCs showed the strongest inhibition of inflammatory indexes of air pouch fluid weight, leukocyte infiltration, granulation tissue weight and nitric oxide concentration in comparison with free drugs and DXM loaded Bare-NLCs. dxm 53-56 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 64-67 23612355-8 2013 Through intravenous administration, a single dose of DXM loaded Pen-NLCs showed the strongest inhibition of inflammatory indexes of air pouch fluid weight, leukocyte infiltration, granulation tissue weight and nitric oxide concentration in comparison with free drugs and DXM loaded Bare-NLCs. Nitric Oxide 210-222 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 64-67 23612355-8 2013 Through intravenous administration, a single dose of DXM loaded Pen-NLCs showed the strongest inhibition of inflammatory indexes of air pouch fluid weight, leukocyte infiltration, granulation tissue weight and nitric oxide concentration in comparison with free drugs and DXM loaded Bare-NLCs. dxm 271-274 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 64-67 23859434-15 2013 CONCLUSIONS: Patients with T2DM initiating insulin glargine treatment showed low rates of hypoglycemia, especially when using a disposable pen device. Insulin Glargine 51-59 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 139-142 24347694-2 2013 Dodecapeptides containing N-terminal, C-terminal, or N- and C-terminal Pen were serially ligated into 36 amino acid polypeptides linked through Cys-Pen, Pen-Cys or Pen-Pen disulfide bonds. Cysteine 144-147 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 148-151 24347694-2 2013 Dodecapeptides containing N-terminal, C-terminal, or N- and C-terminal Pen were serially ligated into 36 amino acid polypeptides linked through Cys-Pen, Pen-Cys or Pen-Pen disulfide bonds. Cysteine 144-147 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 148-151 24347694-2 2013 Dodecapeptides containing N-terminal, C-terminal, or N- and C-terminal Pen were serially ligated into 36 amino acid polypeptides linked through Cys-Pen, Pen-Cys or Pen-Pen disulfide bonds. Cysteine 144-147 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 148-151 24347694-2 2013 Dodecapeptides containing N-terminal, C-terminal, or N- and C-terminal Pen were serially ligated into 36 amino acid polypeptides linked through Cys-Pen, Pen-Cys or Pen-Pen disulfide bonds. Cysteine 144-147 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 148-151 23763182-1 2013 In this work, we have reported a template-free hydrothermal approach to fabricate highly pure single phase ZnMn2O4 pen-type nano needles assembled with flower type nanostructures. znmn2o4 107-114 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 115-118 23553999-2 2013 After being off the market for 4 years, penicilloyl-polylysine was reintroduced in 2009 as PRE-PEN. penicilloyl polylysine 40-62 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 95-98 23563391-8 2013 Both 8-hydroxyquinoline and D-PEN chelation potencies, similarly to that of trientine, were pH-dependent and decreased with pH. Trientine 76-85 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 30-33 23563391-11 2013 In addition, lower binding affinity of D-PEN compared with 8-hydroxyquinolines and trientine was demonstrated. Trientine 83-92 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 41-44 23635318-2 2013 The pristine protective ligand is racemic penicillamine (rac-Pen), and the products of the ligand exchange reactions include clusters containing both rac-Pen and L-DTT (partial exchange). Penicillamine 42-55 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 61-64 23748521-0 2013 Clinical and economic outcomes among patients with diabetes mellitus initiating insulin glargine pen versus vial. Insulin Glargine 88-96 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 97-100 23763182-3 2013 Single crystalline hetaerolite ZnMn2O4 pen type nanoneedles of flower like nanostructures have an average diameter of 250 nm. hetaerolite 19-30 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 39-42 23763182-3 2013 Single crystalline hetaerolite ZnMn2O4 pen type nanoneedles of flower like nanostructures have an average diameter of 250 nm. znmn2o4 31-38 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 39-42 23261512-1 2013 The structure and stability of D-penicillamine-capped gold nanoparticles (d-Pen Au NPs) were studied using spectroscopic tools. Penicillamine 31-46 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 76-79 23534656-1 2013 Using thermal desorption spectroscopy (TDS) the thermal stability of binary pentacene/perfluoropentacene (PEN/PFP) thin films has been investigated for various preparation protocols. Perfluoropentacene 86-104 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 106-109 22580439-2 2013 METHODS: This study evaluated a newly developed noninvasive mobile pen-shaped meibography system comprising an infrared light-emitting diode as the light source and a highly sensitive complementary metal oxide semiconductor image camera. metal oxide 198-209 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 67-70 23261512-4 2013 The three thiol, carboxyl, and amino binding groups of d-Pen were presumed to interact with Au NP surfaces on the basis of the infrared spectral features. Sulfhydryl Compounds 10-15 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 57-60 24109731-1 2013 This study demonstrates the advantage of Dip-Pen Nanolithography (DPN) as a research and design tool for metal nano-structure fabrications. dpn 66-69 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 45-48 24109731-1 2013 This study demonstrates the advantage of Dip-Pen Nanolithography (DPN) as a research and design tool for metal nano-structure fabrications. Metals 105-110 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 45-48 23134102-6 2012 In comparison, only 21 pharmacists (21/38; 55.3%) agreed to administer an adrenaline auto-injector (Epi-Pen) for a child experiencing an anaphylaxis, with nine respondents (9/38; 23.7%) indicating that they would ask the mother for directions in a situation where they were unsure how to administer it. Epinephrine 74-84 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 104-107 22569685-1 2013 The aim of this in vitro study was to determine the influence of cross-infection control methods, as probe tip autoclaving and polyvinyl chloride (PVC) wrapping, on the performance of laser fluorescence device (DIAGNOdent pen--LFpen) on occlusal surfaces of primary molars. Polyvinyl Chloride 127-145 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 222-225 23186160-3 2012 After inkjet-printed or pen-written on plastic sheets, DEA in the silver ink decomposes at temperatures higher than 50 C and generates formaldehyde, which reacts spontaneously with silver ammonia ions to form silver thin films. Formaldehyde 136-148 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 24-27 23186160-3 2012 After inkjet-printed or pen-written on plastic sheets, DEA in the silver ink decomposes at temperatures higher than 50 C and generates formaldehyde, which reacts spontaneously with silver ammonia ions to form silver thin films. Ammonia 189-196 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 24-27 23649255-4 2013 SDS-PAGE of the purified protein showed a band at approximately 35 kDa that cross-reacted with IgE from the serum of a shrimp-allergic patient, identifying it as Pen j 1. Sodium Dodecyl Sulfate 0-3 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 162-165 23649255-5 2013 The circular dichroism spectrum of native Pen j 1 revealed the common alpha-helical structure of tropomyosins which easily collapsed upon heating to 80 C. However, there were no insoluble aggregates after heating, and the protein regained its native CD spectral pattern after cooling to 25 C. There was no significant difference in total IgG production between mice sensitized with native and heated Pen j 1. Cadmium 251-253 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 42-45 23863998-0 2013 Femtolitre chemistry assisted by microfluidic pen lithography. femtolitre 0-10 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 46-49 23863998-3 2013 This method, named microfluidic pen lithography, allows mixing reagents in isolated femtolitre droplets that can be used as reactors to conduct independent reactions and crystallization processes. femtolitre 84-94 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 32-35 23294785-3 2012 Using an insulin pen with memory function might facilitate corrective dosing to avoid postprandial blood glucose peaks and therefore might improve overall glycemic control. Glucose 105-112 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 17-20 22936617-2 2012 In the carbon-based fiber supercapacitor (FSC), which has high capacitance performance, commercial pen ink is directly utilized as the electrochemical material. Carbon 7-13 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 99-102 22775367-0 2012 Evaluation of a new reusable insulin pen (ClikSTAR) in Canadian patients with type 1 and type 2 diabetes mellitus receiving insulin glargine. Insulin Glargine 132-140 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 37-40 22777920-0 2012 Polymer pen lithography using dual-elastomer tip arrays. Polymers 0-7 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 8-11 22777920-1 2012 Dual-elastomer tip arrays are developed as a simple and cost-effective approach to significantly improve the uniformity and precision of polymer pen lithography (PPL). Polymers 137-144 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 145-148 22488791-0 2012 Polymer pen lithography (PPL)-induced site-specific click chemistry for the formation of functional glycan arrays. Polymers 0-7 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 8-11 22488791-0 2012 Polymer pen lithography (PPL)-induced site-specific click chemistry for the formation of functional glycan arrays. Polysaccharides 100-106 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 8-11 22488791-1 2012 Polymer pen lithography (PPL) can be combined with the Cu(I) -catalyzed azide-alkyne click reaction to create molecular arrays with control over orientation and sub-1 mum feature sizes over cm(2) areas. Polymers 0-7 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 8-11 22627738-1 2012 The present work demonstrates for the first time patterning of a ready-to-use biosensor with several different biomolecules using Dip-Pen Nanolithography (DPN) for the development of a procedure towards more rapid and efficient multi-sample detection. dpn 155-158 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 134-137 22488791-1 2012 Polymer pen lithography (PPL) can be combined with the Cu(I) -catalyzed azide-alkyne click reaction to create molecular arrays with control over orientation and sub-1 mum feature sizes over cm(2) areas. cuprous ion 55-60 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 8-11 22488791-1 2012 Polymer pen lithography (PPL) can be combined with the Cu(I) -catalyzed azide-alkyne click reaction to create molecular arrays with control over orientation and sub-1 mum feature sizes over cm(2) areas. azide-alkyne 72-84 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 8-11 21335346-16 2011 CONCLUSION: Chondrocyte viability is significantly reduced when cells are cultured in vitro on collagen membranes marked with methylene blue and crystal violet pen ink. Gentian Violet 145-159 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 160-163 23610669-2 2012 This study investigates the effect of a gentian violet ink marker pen, a common surgical marker, on the viability of the tissue and cells of tendon. Gentian Violet 40-54 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 66-69 21463395-0 2011 Bacterial colonization on writing pens touched by healthcare professionals and hospitalized patients with and without cleaning the pen with alcohol-based hand sanitizing agent. Alcohols 140-147 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 34-37 20926113-7 2010 Thus, for a very first assessment, the OECD approved biodegradation Zahn-Wellens test (ZWT, OECD 302 B) was used to study biodegradation and non-biotic elimination of the antibiotic Benzyl-penicillin (Pen-G) at different temperatures (5 C, 12.5 C and 20 C). Penicillin G 182-199 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 201-204 21224041-6 2011 These morphine-mediated actions on the anti-HIV miRNAs and HIV could be antagonized by the opioid receptor antagonists (naltrexone or Cys2, Tyr3, Arg5, Pen7-amide). Morphine 6-14 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 152-155 21138264-1 2010 We report that nanostructuring via dip-pen nanolithography can be used for modification of a broad range of different substrates (polystyrene, Teflon, stainless steel, glass, silicon, rubber, etc.) Polystyrenes 130-141 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 39-42 21138264-1 2010 We report that nanostructuring via dip-pen nanolithography can be used for modification of a broad range of different substrates (polystyrene, Teflon, stainless steel, glass, silicon, rubber, etc.) Stainless Steel 151-166 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 39-42 21600387-1 2011 BACKGROUND: In separate randomized, crossover trials, patients with diabetes reported a preference for durable insulin pen NovoPen( ) 4 compared with NovoPen 3 and OptiClik( ). novopen 123-130 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 119-122 20926113-11 2010 This hydrolyzed Pen-G was subsequently further degraded by decarboxylation, the result of which was 2-(5,5-dimethyl-1,3-thiazolidin-2-yl)-2-(2-phenylacetamido)acetic acid. 2-(5,5-dimethyl-1,3-thiazolidin-2-yl)-2-(2-phenylacetamido)acetic acid 100-170 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 16-19 20926113-12 2010 Furthermore, direct elimination of 2-phenyl-acetaldehyde from the hydrolyzed and decarboxylated Pen-G also led to the formation of 2-[amino(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidone-4-carboxylic acid. phenylacetaldehyde 35-56 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 96-99 20926113-12 2010 Furthermore, direct elimination of 2-phenyl-acetaldehyde from the hydrolyzed and decarboxylated Pen-G also led to the formation of 2-[amino(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidone-4-carboxylic acid. 2-[amino(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidone-4-carboxylic acid 131-203 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 96-99 20617791-3 2010 As a result of the introduction of cyclic and topological constraints with penicillamines, 2 (Tyr-cyclo[d-Pen-Gly-Phe-Pen]-Pro-Leu-Trp-NH-[3",5"-(CF(3))(2)-Bzl]) was found as the best bifunctional compound with effective NK1 antagonist and potent opioid agonist activities, and 1400-fold delta-selectivity over the mu-receptor. Penicillamine 75-89 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 106-109 21137428-2 2010 These blue ballpoint pens were classified into 34 groups according to their metal element components, among which, 26 groups can be directly distinguished according to the types of metal element components contained in the ballpoint pen, the other groups can be distinguished by different element response ratios. Metals 76-81 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 21-24 21137428-2 2010 These blue ballpoint pens were classified into 34 groups according to their metal element components, among which, 26 groups can be directly distinguished according to the types of metal element components contained in the ballpoint pen, the other groups can be distinguished by different element response ratios. Metals 181-186 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 21-24 20621465-1 2010 Writing a molecularly imprinted polymer (MIP) by nano-fountain pen on surface-enhanced Raman scattering (SERS)-active surfaces resulted in site-controlled arrays of microdots of approximately 6-12mum in diameter. sers 105-109 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 63-66 20920444-2 2010 ClikSTAR (sanofi-aventis) is a novel reusable insulin pen for injecting either long-acting insulin glargine or short-acting insulin glulisine. Insulin Glargine 100-108 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 55-58 20920444-2 2010 ClikSTAR (sanofi-aventis) is a novel reusable insulin pen for injecting either long-acting insulin glargine or short-acting insulin glulisine. glulisine 133-142 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 55-58 20617791-3 2010 As a result of the introduction of cyclic and topological constraints with penicillamines, 2 (Tyr-cyclo[d-Pen-Gly-Phe-Pen]-Pro-Leu-Trp-NH-[3",5"-(CF(3))(2)-Bzl]) was found as the best bifunctional compound with effective NK1 antagonist and potent opioid agonist activities, and 1400-fold delta-selectivity over the mu-receptor. Penicillamine 75-89 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 118-121 20617791-3 2010 As a result of the introduction of cyclic and topological constraints with penicillamines, 2 (Tyr-cyclo[d-Pen-Gly-Phe-Pen]-Pro-Leu-Trp-NH-[3",5"-(CF(3))(2)-Bzl]) was found as the best bifunctional compound with effective NK1 antagonist and potent opioid agonist activities, and 1400-fold delta-selectivity over the mu-receptor. tyr-cyclo 94-103 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 106-109 20617791-3 2010 As a result of the introduction of cyclic and topological constraints with penicillamines, 2 (Tyr-cyclo[d-Pen-Gly-Phe-Pen]-Pro-Leu-Trp-NH-[3",5"-(CF(3))(2)-Bzl]) was found as the best bifunctional compound with effective NK1 antagonist and potent opioid agonist activities, and 1400-fold delta-selectivity over the mu-receptor. tyr-cyclo 94-103 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 118-121 20617791-3 2010 As a result of the introduction of cyclic and topological constraints with penicillamines, 2 (Tyr-cyclo[d-Pen-Gly-Phe-Pen]-Pro-Leu-Trp-NH-[3",5"-(CF(3))(2)-Bzl]) was found as the best bifunctional compound with effective NK1 antagonist and potent opioid agonist activities, and 1400-fold delta-selectivity over the mu-receptor. BZL 156-159 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 106-109 20617791-3 2010 As a result of the introduction of cyclic and topological constraints with penicillamines, 2 (Tyr-cyclo[d-Pen-Gly-Phe-Pen]-Pro-Leu-Trp-NH-[3",5"-(CF(3))(2)-Bzl]) was found as the best bifunctional compound with effective NK1 antagonist and potent opioid agonist activities, and 1400-fold delta-selectivity over the mu-receptor. BZL 156-159 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 118-121 20515311-6 2010 One study assessed influence on glycemic control, and whereas no significant difference was found with respect to hemoglobin A1c, fasting glucose levels decreased significantly more in pen users versus syringe users (-57 +/- 14 vs. 1 +/- 13 mg/dL, P = 0.003). Glucose 138-145 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 185-188 21567539-0 2010 Towards nanowriting on plastics: dip-pen nanolithography of acrylamido-functionalized oligonucleotides on polystyrene. Oligonucleotides 86-102 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 37-40 21567539-0 2010 Towards nanowriting on plastics: dip-pen nanolithography of acrylamido-functionalized oligonucleotides on polystyrene. Polystyrenes 106-117 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 37-40 21567539-1 2010 Model high density DNA arrays have been realized by direct deposition with Dip-Pen Nanolithography of acrylamido-functionalized oligonucleotides (23-mer) on spin-coated, flat polystyrene surfaces. acrylamido 102-112 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 79-82 21567539-1 2010 Model high density DNA arrays have been realized by direct deposition with Dip-Pen Nanolithography of acrylamido-functionalized oligonucleotides (23-mer) on spin-coated, flat polystyrene surfaces. Oligonucleotides 128-144 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 79-82 20532409-4 2010 The ink is incorporated into a felt tip pen and applied to a number of different substrates, producing a distinct, reversible colour change on all tested surfaces, when a sufficient level of carbon dioxide is present. Carbon Dioxide 191-205 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 40-43 20184292-0 2010 "Force-feedback" leveling of massively parallel arrays in polymer pen lithography. Polymers 58-65 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 66-69 20358984-1 2010 Highly pure 6,13-bis(triisopropylsilylethynyl)pentacene (TIPS-PEN) nanofilms were deposited on a hydrophobic OTS-SAM surface at two different substrate temperatures (70 degrees C and 90 degrees C) via the vacuum thermal evaporation (VTE) method. TIPS-pentacene 12-55 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 62-65 20184292-1 2010 Polymer pen lithography is a recently developed molecular printing technique which can produce features with diameters ranging from 80 nm to >10 microm in a single writing step using massively parallel (>10(7) pens) arrays of pyramidal, elastomeric pens. Polymers 0-7 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 8-11 20559002-8 2010 In addition, the decrease in CD44 expression can be abolished by pre-treating Pen ch 13 with a serine protease inhibitor, phenylmethyl-sulfonyl fluoride. Phenylmethylsulfonyl Fluoride 122-152 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 78-81 20496440-0 2010 Nanopatterning of catalyst by Dip Pen nanolithography (DPN) for synthesis of carbon nanotubes (CNT). dpn 55-58 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 34-37 20496440-0 2010 Nanopatterning of catalyst by Dip Pen nanolithography (DPN) for synthesis of carbon nanotubes (CNT). Carbon 77-83 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 34-37 20496440-3 2010 Dip pen nanolithography technique was used to deposit NiCl(2) nanopatterns with sub-200 nm feature sizes on a silicon substrate. Silicon 110-117 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 20496441-0 2010 Self-leveling two-dimensional probe arrays for Dip Pen Nanolithography. 3,5-diisopropylsalicylic acid 47-50 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 51-54 19845335-2 2009 In combination with a solvent-free ionic liquid electrolyte, we have demonstrated a approximately 6.5% cell with an amphiphilic ruthenium polypyridyl photosensitizer showing excellent stability measured under prolonged light soaking at 60 degrees C. Compared to the Pt deposited PEN film, the CoS deposited PEN film shows higher electrocatalytic activity for the reduction of triiodide. Ruthenium 128-137 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 279-282 19852486-0 2009 Dip-pen nanolithography of electrical contacts to single-walled carbon nanotubes. Carbon 64-70 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 19852486-1 2009 This paper discusses a method for the direct patterning of Au electrodes at nanoscale resolution using dip-pen nanolithography, with proof-of-concept demonstrated by creating single-walled carbon nanotube devices. Gold 59-61 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 107-110 19845335-2 2009 In combination with a solvent-free ionic liquid electrolyte, we have demonstrated a approximately 6.5% cell with an amphiphilic ruthenium polypyridyl photosensitizer showing excellent stability measured under prolonged light soaking at 60 degrees C. Compared to the Pt deposited PEN film, the CoS deposited PEN film shows higher electrocatalytic activity for the reduction of triiodide. Ruthenium 128-137 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 307-310 19689100-0 2009 Controlled assembly of gold nanoparticles and graphene oxide sheets on dip pen nanolithography-generated templates. graphene oxide 46-60 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 75-78 19800477-1 2009 A recently proposed electroanalytical method, using differential pulse voltammetry (DPV) on the rotating Au-disk electrode, and electrospray ionization mass-spectrometry (ESI-MS) has been applied to study the binding of the pharmaceutical chelating agents meso-2,3-dimercaptosuccinic acid (DMSA), sodium 2,3-dimercaptopropanesulfate (DMPS) and D-penicillamine (D-Pen) with Hg(2+). Gold 105-107 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 363-366 19821927-5 2009 Overall, mean IOP was 18.3 +/- 4.8 mmHg using GAT and 18.8 +/- 5.5 mmHg using the Tono-Pen. tono 82-86 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 87-90 19689100-3 2009 The templates were obtained by passivation of the exposed Au area with AUT after 16-mercaptohexadecanoic acid (MHA) patterns were generated by dip-pen nanolithography (DPN) on Au. Gold 58-60 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 147-150 19689100-3 2009 The templates were obtained by passivation of the exposed Au area with AUT after 16-mercaptohexadecanoic acid (MHA) patterns were generated by dip-pen nanolithography (DPN) on Au. 16-mercaptohexadecanoic acid 81-109 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 147-150 19689100-3 2009 The templates were obtained by passivation of the exposed Au area with AUT after 16-mercaptohexadecanoic acid (MHA) patterns were generated by dip-pen nanolithography (DPN) on Au. 16-mercaptohexadecanoic acid 111-114 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 147-150 19465296-7 2009 In the 2 groups in which an oil-based pen was used, the corneal flap could not be lifted. Oils 28-31 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 38-41 19644851-5 2009 RESULTS: At study entry, the mean MRSS value was 21.0 in the D-Pen Trial cohort, 27.3 in the Relaxin Trial cohort, and 26.1 in the Collagen Trial cohort. Deuterium 61-62 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 63-66 19557559-6 2009 Unlike mauveine, which is now a chemical curiosity, fuchsine is still in use as a biological stain, especially in Schiff"s reagent for detecting aldehydes, industrially as a dye in coloring various materials from textile fibers to ball point pen inks, analytically as a visualization agent for thin layer chromatography, and as an antifungal agent. basic fuchsin 52-60 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 242-245 19407845-5 2009 RESULTS: Stepwise multiple regression analysis indicated that GAT (P=0.017) and DCT (P=0.002) readings correlated positively with MK; GAT, NCT, and Tono-Pen readings correlated positively with CCT (P<0.05); NCT (P=0.035), and DCT (P=0.016) readings correlated negatively with LT; GAT (P=0.006) and Tono-Pen (P=0.009) readings correlated positively with OPA. dct 80-83 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 153-156 19674222-0 2009 Improvement in health-related quality of life, independent of fasting glucose concentration, via insulin pen device in diabetic patients. Glucose 70-77 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 51-54 19674222-8 2009 In comparison with baseline, fasting glucose significantly decreased in the insulin pen group (-57 +/- 14 mg dL(-1), P < 0.001), and the reduction was significantly greater than that in the syringe group (P = 0.003). Glucose 37-44 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 84-87 19601651-0 2009 Writing droplets of molecularly imprinted polymers by nano fountain pen and detecting their molecular interactions by surface-enhanced Raman scattering. Polymers 42-50 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 68-71 19601651-1 2009 Molecularly imprinted polymer (MIP) droplets were printed using a pipet or a nano fountain pen on surface-enhanced Raman scattering (SERS)-active surfaces, to directly monitor the uptake and release of a template molecule, the beta-blocking drug propranolol, by SERS. Polymers 22-29 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 91-94 19465296-8 2009 In the 2 groups in which a water-based pen was used, the corneal flap was easily lifted. Water 27-32 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 39-42 19492310-1 2009 The ability to deposit different materials with nanoscale precision at user-specified locations is a very important attribute of dip pen nanolithography (DPN). dpn 154-157 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 133-136 21706669-4 2009 The investigations show that the "pen" actually is a small oxygen bubble between the counter electrode and the sample surface. Oxygen 59-65 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 34-37 20596481-4 2009 We demonstrate that by using Dip-Pen Nanolithography, individual DNA molecules attached to modified mica surfaces can be efficiently digested by DNase I. mica 100-104 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 33-36 19220655-2 2009 Recent research suggests that the degradation of triarylmethane dyes gives an indication of the age of a ballpoint pen entry on a document. triarylmethane 49-63 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 115-118 19626896-0 2009 [Analysis of roller ball pen water ink by capillary electrophoresis with photodiode array detector]. Water 29-34 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 25-28 19626896-1 2009 The analytical method of roller ball pen water inks was established by capillary electrophoresis with photodiode array (PDA) detector scanning in row. Water 41-46 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 37-40 18562017-6 2008 The specific mu opioid receptor antagonist, Cys2, Tyr3, Arg5, Pen7-amide (CTAP), also blocked the morphine action on intracellular IFN-alpha expression. CTAP 74-78 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 62-65 19218125-5 2009 Compared with conventional injections, the prefilled pen was associated with significantly lowered rate of local redness, high rate of local bruise, more frequent follitropin dose modulation and lower serum oestradiol levels on HCG day. Estradiol 207-217 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 53-56 18800771-3 2008 The cyclic peptide (2 S)-Mdcp-c[D-Cys-Gly-Phe(pNO 2)-D-Cys]NH 2 (1) was a potent and selective mu antagonist, whereas (2 S)-Mdcp-c[D-Pen-Gly-Phe(pF)-Pen]-Phe-OH (3) showed subnanomolar delta antagonist activity and extraordinary delta selectivity. Peptides, Cyclic 4-18 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 133-136 18800771-3 2008 The cyclic peptide (2 S)-Mdcp-c[D-Cys-Gly-Phe(pNO 2)-D-Cys]NH 2 (1) was a potent and selective mu antagonist, whereas (2 S)-Mdcp-c[D-Pen-Gly-Phe(pF)-Pen]-Phe-OH (3) showed subnanomolar delta antagonist activity and extraordinary delta selectivity. Peptides, Cyclic 4-18 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 149-152 18800771-3 2008 The cyclic peptide (2 S)-Mdcp-c[D-Cys-Gly-Phe(pNO 2)-D-Cys]NH 2 (1) was a potent and selective mu antagonist, whereas (2 S)-Mdcp-c[D-Pen-Gly-Phe(pF)-Pen]-Phe-OH (3) showed subnanomolar delta antagonist activity and extraordinary delta selectivity. s)-mdcp-c 22-31 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 133-136 18800771-3 2008 The cyclic peptide (2 S)-Mdcp-c[D-Cys-Gly-Phe(pNO 2)-D-Cys]NH 2 (1) was a potent and selective mu antagonist, whereas (2 S)-Mdcp-c[D-Pen-Gly-Phe(pF)-Pen]-Phe-OH (3) showed subnanomolar delta antagonist activity and extraordinary delta selectivity. s)-mdcp-c 22-31 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 149-152 18800771-3 2008 The cyclic peptide (2 S)-Mdcp-c[D-Cys-Gly-Phe(pNO 2)-D-Cys]NH 2 (1) was a potent and selective mu antagonist, whereas (2 S)-Mdcp-c[D-Pen-Gly-Phe(pF)-Pen]-Phe-OH (3) showed subnanomolar delta antagonist activity and extraordinary delta selectivity. )-mdcp-c 23-31 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 133-136 18800771-3 2008 The cyclic peptide (2 S)-Mdcp-c[D-Cys-Gly-Phe(pNO 2)-D-Cys]NH 2 (1) was a potent and selective mu antagonist, whereas (2 S)-Mdcp-c[D-Pen-Gly-Phe(pF)-Pen]-Phe-OH (3) showed subnanomolar delta antagonist activity and extraordinary delta selectivity. )-mdcp-c 23-31 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 149-152 18774652-5 2009 In this review we discuss the targeting of the elevated copper (both in serum and tumor) and oxidative stress levels in cancer with the aid of a copper chelator d-penicillamine (d-pen) for potential cancer treatment. Copper 56-62 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 163-166 18774652-5 2009 In this review we discuss the targeting of the elevated copper (both in serum and tumor) and oxidative stress levels in cancer with the aid of a copper chelator d-penicillamine (d-pen) for potential cancer treatment. Copper 145-151 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 163-166 18703709-2 2008 Polymer pen lithography merges the feature size control of dip-pen nanolithography with the large-area capability of contact printing. Polymers 0-7 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 8-11 18703709-2 2008 Polymer pen lithography merges the feature size control of dip-pen nanolithography with the large-area capability of contact printing. Polymers 0-7 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 63-66 18562017-6 2008 The specific mu opioid receptor antagonist, Cys2, Tyr3, Arg5, Pen7-amide (CTAP), also blocked the morphine action on intracellular IFN-alpha expression. Morphine 98-106 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 62-65 19484849-0 2008 Solostar pen for glargine and glulisine insulins: line extension. Insulin Glargine 17-25 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 9-12 18593193-2 2008 In this paper, we demonstrate that the dip pen nanolithography (DPN) method can be used to precisely functionalize multiple electrical gaps for multiplexed DNA detection. 3,5-diisopropylsalicylic acid 39-42 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 43-46 18715206-10 2008 CONCLUSIONS: The SoloSTAR pen allows people with diabetes to achieve a dosing accuracy with glargine and glulisine similar to that achieved in laboratory conditions. Insulin Glargine 92-100 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 26-29 18715206-10 2008 CONCLUSIONS: The SoloSTAR pen allows people with diabetes to achieve a dosing accuracy with glargine and glulisine similar to that achieved in laboratory conditions. glulisine 105-114 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 26-29 17920262-1 2008 The main purpose of this research was to investigate the antitumor and antimicrobial activities of the chitooligosaccharides containing hydrolyzates obtained from the hydrolysis of chitinous materials (such as chitin, chitosan, and squid pen) by bromelain. oligochitosan 103-124 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 238-241 18700497-0 2008 Quantitative evaluation of europium in blue ballpoint pen inks/offset printing inks tagged with europium thenoyltrifluoroacetonate by spectrofluorometry and ICP-AES. thenoyltrifluoroacetonate 105-130 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 54-57 18554252-4 2008 To increase the bioactivity of cIBR peptide, we systemically modified the structure of the peptide by (i) replacing the Pen residue at the N-terminus with Cys, (ii) cyclization using amide bond formation between Lys-Glu side chains, and (iii) reducing the peptide size by eliminating the C-terminal residue. cIBR peptide 31-43 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 120-123 18547104-0 2008 Preparation of chitin nanofibers from squid pen beta-chitin by simple mechanical treatment under acid conditions. beta-chitin 48-59 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 44-47 18547104-2 2008 The key factors to prepare the chitin nanofibers with such high aspect ratios are as follows: (1) squid pen beta-chitin is used as the starting material and (2) ultrasonication of the beta-chitin in water at pH 3-4 and 0.1-0.3% consistency for a few minutes. Chitin 31-37 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 104-107 18547104-2 2008 The key factors to prepare the chitin nanofibers with such high aspect ratios are as follows: (1) squid pen beta-chitin is used as the starting material and (2) ultrasonication of the beta-chitin in water at pH 3-4 and 0.1-0.3% consistency for a few minutes. beta-chitin 108-119 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 104-107 18547104-3 2008 Transparent and highly viscous dispersions of squid pen beta-chitin nanofibers in water can be obtained by this method. beta-chitin 56-67 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 52-55 18547104-3 2008 Transparent and highly viscous dispersions of squid pen beta-chitin nanofibers in water can be obtained by this method. Water 82-87 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 52-55 18547104-6 2008 Cationization of the C2 amino groups present on the crystallite surfaces of the squid pen beta-chitin under acid conditions is necessary for preparing the nanofibers. beta-chitin 90-101 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 86-89 18404990-3 2008 DNA was extracted from the epithelial cells on fountain pen by silicon bead and was genotyped by Identifier kit. Silicon 63-70 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 56-59 18210043-4 2008 At present, apomorphine injections with the apomorphine pen are underutilised, considering its current indications and contraindications. Apomorphine 12-23 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 56-59 18275107-0 2008 Separation of crystal violet dyes and its application to pen ink analysis using CZE and MEKC methods. Gentian Violet 14-28 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 57-60 18161335-3 2007 Therefore, the methods of gas chromatography and high performance liquid chromatography for analyzing the inks of ball-point pen and water-based pen cannot be used here. Water 133-138 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 145-148 18279246-4 2008 A pulsed nitrogen laser can be focused onto a pen stroke from a pigmented ink pen on paper, and positive and negative ions representative of the pigment can be generated for subsequent mass spectrometric analysis. Nitrogen 9-17 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 46-49 18279246-4 2008 A pulsed nitrogen laser can be focused onto a pen stroke from a pigmented ink pen on paper, and positive and negative ions representative of the pigment can be generated for subsequent mass spectrometric analysis. Nitrogen 9-17 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 78-81 18184536-6 2007 The mean of Meracilina/Pen-Ve-Oral 500,000 UI% geometric mean was 99.89% for AUC0-t, 100.86% for AUC0-infinity and 101.11% for Cmax. meracilina 12-22 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 23-26 18184536-10 2007 CONCLUSION: Since the 90% CI for AUC0-t, AUC0-infinity and Cmax ratios were all within the 80 - 125% interval proposed by the US FDA and accepted by ANVISA, it was concluded that the Meracilina formulation (manufactured by AchA(c) S.A.) is bioequivalent to Pen-Ve-Oral (manufactured by Eurofarma) for both the rate and the extent of bioavailability. meracilina 183-193 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 257-260 17937667-2 2007 Derivatives with penicillamine (H-Pen), cyclohexylalanine (H-Cha), butylglycine (L-t-Bg), and norleucine (H-Nle) showed relatively high inhibitory activities against lipase. Penicillamine 17-30 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 34-37 17937667-2 2007 Derivatives with penicillamine (H-Pen), cyclohexylalanine (H-Cha), butylglycine (L-t-Bg), and norleucine (H-Nle) showed relatively high inhibitory activities against lipase. h-nle 106-111 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 34-37 17918925-1 2007 The antiarthritis drug D-penicillamine (D-PEN) catalyzes zinc(II) transfer from carboxypeptidase A to chelators such as thionein and EDTA at a rate constant up to 400-fold faster than the uncatalyzed release. Penicillamine 23-38 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 42-45 17918925-1 2007 The antiarthritis drug D-penicillamine (D-PEN) catalyzes zinc(II) transfer from carboxypeptidase A to chelators such as thionein and EDTA at a rate constant up to 400-fold faster than the uncatalyzed release. Lys-Cys-Thr-Cys-Cys-Ala 120-128 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 42-45 17918925-1 2007 The antiarthritis drug D-penicillamine (D-PEN) catalyzes zinc(II) transfer from carboxypeptidase A to chelators such as thionein and EDTA at a rate constant up to 400-fold faster than the uncatalyzed release. Edetic Acid 133-137 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 42-45 17918925-2 2007 Once D-PEN releases zinc(II) from enzyme stronger chelators can tightly bind zinc(II) leading to complete and essentially irreversible inhibition. Zinc 20-28 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 7-10 17918925-2 2007 Once D-PEN releases zinc(II) from enzyme stronger chelators can tightly bind zinc(II) leading to complete and essentially irreversible inhibition. Zinc 77-85 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 7-10 17918925-3 2007 D-PEN is the first drug to inhibit a zinc protease by catalyzing metal removal, and the name "catalytic chelation" is proposed for this mechanism. Metals 65-70 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 2-5 17940647-1 2007 The complex formation between mercury(II) and penicillamine (H(2)Pen = 3,3"-dimethyl cysteine) in alkaline aqueous solutions (pH approximately 2) has been investigated with extended X-ray absorption fine structure (EXAFS) and 199Hg NMR spectroscopy. Mercury 30-37 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 65-68 17940647-1 2007 The complex formation between mercury(II) and penicillamine (H(2)Pen = 3,3"-dimethyl cysteine) in alkaline aqueous solutions (pH approximately 2) has been investigated with extended X-ray absorption fine structure (EXAFS) and 199Hg NMR spectroscopy. Penicillamine 46-59 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 65-68 17940647-1 2007 The complex formation between mercury(II) and penicillamine (H(2)Pen = 3,3"-dimethyl cysteine) in alkaline aqueous solutions (pH approximately 2) has been investigated with extended X-ray absorption fine structure (EXAFS) and 199Hg NMR spectroscopy. Penicillamine 71-93 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 65-68 18035204-22 2007 CONCLUSIONS: This study found that teriparatide pen injection was well accepted in these patients, and acceptance rates improved during the first 6 months of treatment and, thereafter, improved slightly for approximately 18 months. Teriparatide 35-47 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 48-51 18035204-24 2007 Teriparatide pen injection was a viable treatment in these osteopenic or osteoporotic patients with fragility fractures. Teriparatide 0-12 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 13-16 17408805-4 2007 PEN-peptoid showed greater cell viability and as a consequence better efficiency as an apoptosis inhibitor than the TAT-peptoid. tat-peptoid 116-127 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 0-3 17335413-1 2007 SoloStar (sanofi-aventis) is a new, disposable insulin pen for the administration of insulin glargine (Lantus, sanofi-aventis) or insulin glulisine (Apidra, sanofi-aventis). sanofi-aventis 10-24 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 55-58 17404307-12 2007 These finding show that Pen c 13 induces IL-8 release in airway epithelial cells and that this is dependent on PAR-1 and PAR-2 activation and intracellular calcium. Calcium 156-163 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 24-27 17275091-2 2007 D-Pen reduces Cu(II) to Cu(I) in the process of chelation while at the same time being oxidized to D-penicillamine disulfide. cu(ii) 14-20 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 2-5 17275091-2 2007 D-Pen reduces Cu(II) to Cu(I) in the process of chelation while at the same time being oxidized to D-penicillamine disulfide. cuprous ion 24-29 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 2-5 17275091-2 2007 D-Pen reduces Cu(II) to Cu(I) in the process of chelation while at the same time being oxidized to D-penicillamine disulfide. penicillamine disulfide 99-124 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 2-5 17404307-9 2007 Moreover, Pen c 13-mediated IL-8 release was significantly decreased in Ca(2+)-free medium and was abolished by the protease inhibitors, PMSF and 4-(2-aminoethyl) benzenesulfonyl fluoride. Phenylmethylsulfonyl Fluoride 137-141 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 10-13 17404307-9 2007 Moreover, Pen c 13-mediated IL-8 release was significantly decreased in Ca(2+)-free medium and was abolished by the protease inhibitors, PMSF and 4-(2-aminoethyl) benzenesulfonyl fluoride. 4-(2-aminoethyl)benzenesulfonylfluoride 146-187 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 10-13 17335413-1 2007 SoloStar (sanofi-aventis) is a new, disposable insulin pen for the administration of insulin glargine (Lantus, sanofi-aventis) or insulin glulisine (Apidra, sanofi-aventis). Insulin Glargine 93-101 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 55-58 17335413-1 2007 SoloStar (sanofi-aventis) is a new, disposable insulin pen for the administration of insulin glargine (Lantus, sanofi-aventis) or insulin glulisine (Apidra, sanofi-aventis). Insulin Glargine 103-109 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 55-58 17335413-1 2007 SoloStar (sanofi-aventis) is a new, disposable insulin pen for the administration of insulin glargine (Lantus, sanofi-aventis) or insulin glulisine (Apidra, sanofi-aventis). glulisine 138-147 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 55-58 17028000-3 2006 The chromatographic conditions for separation of the dye-based black gel pen inks were optimized and the dye components in inks were satisfactorily separated by using 40 mmol/L tetrabutylammonium bromide as ion-pairing reagent. tetrabutylammonium 177-203 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 73-76 16586368-1 2006 BACKGROUND: We evaluated the impact of resistant penicillin-binding protein (PBP) allele acquisition on the ability of penicillin-resistant (PEN-R) pneumococcal strains to compete with penicillin-susceptible (PEN-S) ancestors for upper-respiratory-tract (URT) colonization. Penicillins 49-59 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 141-144 17020056-0 2006 [Determination of copper and chromium in the cartridges of permanent marker pen and ink by ICP-AES]. Copper 18-24 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 76-79 17020056-0 2006 [Determination of copper and chromium in the cartridges of permanent marker pen and ink by ICP-AES]. Chromium 29-37 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 76-79 17020056-1 2006 The method for the determination of copper and chromium in the cartridges of permanent pen oil base and ink by ICP-AES was reported. Copper 36-42 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 87-90 17020056-1 2006 The method for the determination of copper and chromium in the cartridges of permanent pen oil base and ink by ICP-AES was reported. Chromium 47-55 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 87-90 16084680-0 2006 Analysis of Indian blue ballpoint pen inks tagged with rare-earth thenoyltrifluoroacetonates by inductively coupled plasma-mass spectrometry and instrumental neutron activation analysis. thenoyltrifluoroacetonates 66-92 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 34-37 16084680-10 2006 This study of tagging metal ions in combination with ICP-MS and NAA as an analytical tool can allow to draw various combination options based on different rare-earth chelates as suitable materials for tagging of ballpoint pen inks for absolute/relative age determination to aid in document related crime examination. Metals 22-27 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 222-225 16675334-8 2006 Mutual adjustment for other exposures did not significantly alter the results for endotoxin and only moderately affected the results for EPS-Pen/Asp. exophthalmos producing substance 137-140 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 141-144 16586368-1 2006 BACKGROUND: We evaluated the impact of resistant penicillin-binding protein (PBP) allele acquisition on the ability of penicillin-resistant (PEN-R) pneumococcal strains to compete with penicillin-susceptible (PEN-S) ancestors for upper-respiratory-tract (URT) colonization. Penicillins 119-129 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 141-144 15896888-7 2006 An adrenaline pen is provided for use in case of anaphylaxis. Epinephrine 3-13 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 14-17 16285023-6 2006 In the uterotonic assay, the substitution with the ureido group at Gln(4) results in retention of high antagonistic potency, albeit somewhat lower than that of PA, e.g. [Orn(Car)(4), Pen(6)]-PA and [Dab(Car)(4), Pen(6)]-PA having pA(2) = 8.52 and pA(2) = 8.42 respectively. Glutamine 67-70 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 212-215 16285023-7 2006 In the pressor assay, [Lys(Car)(4), Pen(6)]-PA and [Dab(Car)(4), Pen(6)]-PA were somewhat weaker antagonists of arginine vasopressin than [Pen(6)]-PA; [Dap(Car)(4), Pen(6)]-PA showed only a faint trace of pressor agonistic activity. Protactinium 42-46 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 36-39 16684431-6 2006 Since teriparatide is administered subcutaneously, it is important that patients receive training on the use of the teriparatide injection device (i.e., the pen device). Teriparatide 116-128 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 157-160 16608296-0 2006 Nano fountain pen manufacture of polymer lenses for nano-biochip applications. Polymers 33-40 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 14-17 16436150-7 2006 RESULTS: Pen ch 13 induced productions of prostaglandin-E2 (PGE2), interleukin (IL)-8 and transforming growth factor (TGF)-beta1 by A549 cells, 16HBE14o- cells and primary cultures of HBEpC. Dinoprostone 42-58 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 9-12 16436150-7 2006 RESULTS: Pen ch 13 induced productions of prostaglandin-E2 (PGE2), interleukin (IL)-8 and transforming growth factor (TGF)-beta1 by A549 cells, 16HBE14o- cells and primary cultures of HBEpC. Dinoprostone 60-64 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 9-12 16436150-8 2006 The protease activity of Pen ch 13 is needed for the induction of PGE2 IL-8, TGF-beta1 and cyclo-oxygenase (COX)-2 expression. Dinoprostone 66-70 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 25-28 16059896-0 2005 Surgery versus steroid injection in carpal tunnel syndrome: comment on the article by Ly-Pen et al. Steroids 15-22 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 89-92 16141253-9 2006 EPS-Pen/Asp exposure was detected in 20% of waste collectors and 49% of compost workers. exophthalmos producing substance 0-3 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 16262418-1 2005 We have succeeded for the first time in preparing a pair of gold nanocluster enantiomers protected by optically active thiols: D- and L-penicillamine (D-Pen and L-Pen). Sulfhydryl Compounds 119-125 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 153-156 16262418-1 2005 We have succeeded for the first time in preparing a pair of gold nanocluster enantiomers protected by optically active thiols: D- and L-penicillamine (D-Pen and L-Pen). Sulfhydryl Compounds 119-125 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 163-166 16262418-1 2005 We have succeeded for the first time in preparing a pair of gold nanocluster enantiomers protected by optically active thiols: D- and L-penicillamine (D-Pen and L-Pen). d- and l-penicillamine 127-149 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 153-156 16262418-1 2005 We have succeeded for the first time in preparing a pair of gold nanocluster enantiomers protected by optically active thiols: D- and L-penicillamine (D-Pen and L-Pen). d- and l-penicillamine 127-149 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 163-166 16262418-2 2005 Circular dichroism (CD) spectroscopy confirmed the mirror image relationship between the D-Pen-capped and the L-Pen-capped gold nanoclusters, suggesting that the surface modifier acts as a chiral selector, and that the nanoclusters have well-defined stereostructures as common chiral molecules do. l 110-111 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 112-115 17196015-1 2006 Bacterial endotoxin, fungal (1 --> 3)-beta-D-glucans, and extracellular polysaccharides from Aspergillus and Penicillium (EPS-Asp/Pen) have been suggested to be stable markers of microbial exposure. Polysaccharides 75-90 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 112-115 17196015-1 2006 Bacterial endotoxin, fungal (1 --> 3)-beta-D-glucans, and extracellular polysaccharides from Aspergillus and Penicillium (EPS-Asp/Pen) have been suggested to be stable markers of microbial exposure. eps-asp 125-132 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 112-115 16176250-6 2005 We also report on the generation of considerably finer structures, with a typical size of 100 nm, which were inscribed onto the polymer surface by the tip of a scanning near-field optical microscope used as an optical pen. Polymers 128-135 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 218-221 15787963-6 2005 The magnitude of this energy penalty depends on the nature of the fourth residue of the peptide (d-Pen or d-Cys) and correlates well with the observed kappa-receptor binding affinity. D-cysteine 106-111 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 99-102 15934064-8 2005 E(pen) is fit in a limited number of selected Zn(II)-mono-ligated complexes so that the sum of E(MTP) and E(pen) reproduces the Coulomb contribution E(c) from an ab initio Hartree-Fock energy decomposition procedure. Zinc 46-52 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 2-5 15934064-8 2005 E(pen) is fit in a limited number of selected Zn(II)-mono-ligated complexes so that the sum of E(MTP) and E(pen) reproduces the Coulomb contribution E(c) from an ab initio Hartree-Fock energy decomposition procedure. Zinc 46-52 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 108-111 15934064-8 2005 E(pen) is fit in a limited number of selected Zn(II)-mono-ligated complexes so that the sum of E(MTP) and E(pen) reproduces the Coulomb contribution E(c) from an ab initio Hartree-Fock energy decomposition procedure. coulomb 128-135 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 2-5 15934064-8 2005 E(pen) is fit in a limited number of selected Zn(II)-mono-ligated complexes so that the sum of E(MTP) and E(pen) reproduces the Coulomb contribution E(c) from an ab initio Hartree-Fock energy decomposition procedure. coulomb 128-135 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 108-111 16120036-7 2005 The NovoPen 3 was also associated with a higher percentage of patients who felt the click sensation than with the Humalog Pen (P < 0.001) and HumaPen Ergo (P < 0.01). Insulin Lispro 114-121 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 8-11 16102480-12 2005 CONCLUSIONS: Tono-Pen readings disagree with Perkins tonometer measurements for measuring IOP in children with PCG who present with IOP greater than 16 mm Hg and tends to overestimate IOP. pcg 111-114 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 18-21 15641022-4 2005 Measurement of the amide proton temperature coefficients revealed solvent shielded hydrogens for Gln(4) and Pen(6) in the major trans-conformer of 1 as well as for Gln(4) in the minor cis-conformer of 2. Amides 19-24 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 108-111 15774273-0 2005 Dip Pen Nanolithography (DPN): process and instrument performance with NanoInk"s NSCRIPTOR system. 3,5-diisopropylsalicylic acid 0-3 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 15774273-4 2005 Dip Pen Nanolithography (DPN) is a scanning-probe-based direct-write technique for generating surface-patterned chemical functionality and discrete structures on the sub-100 nm scale. 3,5-diisopropylsalicylic acid 0-3 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 16833406-4 2005 We synthesized the platinum complex (Syd-PEn-Pt), the unmodified ligands (PEn-H), and the unmodified platinum complexes (PEn-Pt). Platinum 19-27 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 41-44 16126562-11 2005 Risk factors for penicillin resistance were ventilatory support (p<0.01), intubation (p<0.001) and resistance to other antibiotics: 8 of 16 (50%) of PEN-R VSB were resistant also to erythromycin or cotrimoxazole or tetracycline compared with 9% of PEN-R VSB (p<0.005). Penicillins 17-27 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 155-158 16126562-11 2005 Risk factors for penicillin resistance were ventilatory support (p<0.01), intubation (p<0.001) and resistance to other antibiotics: 8 of 16 (50%) of PEN-R VSB were resistant also to erythromycin or cotrimoxazole or tetracycline compared with 9% of PEN-R VSB (p<0.005). Penicillins 17-27 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 254-257 15224381-6 2004 Consequently, this shorter cyclic peptide was used as a template for the development of several synthetic analogues, among which a superagonist, termed P5U: H-Asp-cyclo(Pen-Phe-Trp-Lys-Tyr-Cys)-Val-OH. Peptides 34-41 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 169-172 15378483-1 2004 13C homonuclear through-bond correlations of alpha- and beta-chitin were determined by using two-dimensional (2D) INADEQUATE spectra of these allomorphs purified from crab shell and squid pen, respectively. 13c 0-3 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 188-191 15511333-0 2004 Evaluation of a pen device for self-administration of recombinant human FSH in clomiphene citrate-resistant anovulatory women undergoing ovulation induction. Clomiphene 79-97 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 16-19 15965889-1 2004 The occurrence of L(S)-allo-isocitric acid in nature, as a new fungal product, was first found in the culture medium of Pen. l(s)-allo-isocitric acid 18-42 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 120-123 15224381-6 2004 Consequently, this shorter cyclic peptide was used as a template for the development of several synthetic analogues, among which a superagonist, termed P5U: H-Asp-cyclo(Pen-Phe-Trp-Lys-Tyr-Cys)-Val-OH. p5u 152-155 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 169-172 15224381-6 2004 Consequently, this shorter cyclic peptide was used as a template for the development of several synthetic analogues, among which a superagonist, termed P5U: H-Asp-cyclo(Pen-Phe-Trp-Lys-Tyr-Cys)-Val-OH. h-asp-cyclo 157-168 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 169-172 15224381-6 2004 Consequently, this shorter cyclic peptide was used as a template for the development of several synthetic analogues, among which a superagonist, termed P5U: H-Asp-cyclo(Pen-Phe-Trp-Lys-Tyr-Cys)-Val-OH. val-oh 194-200 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 169-172 15270455-0 2004 Dynamic of the ageing of ballpoint pen inks: quantification of phenoxyethanol by GC-MS. phenoxyethanol 63-77 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 35-38 15315413-2 2004 The electrophilic thiocyanating agent N-thiocyanatosuccinimide (NTS) also reacts with PEN and GSH to yield the corresponding RSSCN derivatives. n-thiocyanatosuccinimide 38-62 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 86-89 15315413-2 2004 The electrophilic thiocyanating agent N-thiocyanatosuccinimide (NTS) also reacts with PEN and GSH to yield the corresponding RSSCN derivatives. nts 64-67 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 86-89 15315413-2 2004 The electrophilic thiocyanating agent N-thiocyanatosuccinimide (NTS) also reacts with PEN and GSH to yield the corresponding RSSCN derivatives. rsscn 125-130 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 86-89 15984231-1 2004 Here, we describe the effect of writing speed in dip pen nanolithography on the morphology (height and density) of self-assembled monolayers of alkanethiols on gold surfaces. 3,5-diisopropylsalicylic acid 49-52 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 53-56 15984231-1 2004 Here, we describe the effect of writing speed in dip pen nanolithography on the morphology (height and density) of self-assembled monolayers of alkanethiols on gold surfaces. alkanethiols 144-156 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 53-56 15236919-1 2004 OBJECTIVE: The emergence of multidrug resistance within Streptococcus pneumoniae population was analysed, correlating penicillin resistance Pen(R) with secondary antibiotic resistance, capsular serotype, and genetic diversity among isolates. Penicillins 118-128 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 140-143 15236919-3 2004 RESULTS: Overall 35% of the isolates were Pen(R) of which 45% demonstrated high-level penicillin (Pen(R)-R, MIC>1). Penicillins 86-96 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 98-101 15063339-1 2004 D-Penicillamine (D-Pen) is a thiol drug used in the treatment of Wilson"s disease, rheumatoid arthritis, metal intoxication and cystinuria. Sulfhydryl Compounds 29-34 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 2-5 15063339-1 2004 D-Penicillamine (D-Pen) is a thiol drug used in the treatment of Wilson"s disease, rheumatoid arthritis, metal intoxication and cystinuria. Metals 105-110 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 2-5 12914799-6 2003 Our results suggest that sequestration of the N-terminal fragment of proSAAS in intracellular PBs may cause a functional disturbance of neurons in Pick"s disease. pbs 94-97 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 69-76 15137481-0 2004 [A notice for use for patients who benifit from an adrenaline pen. Epinephrine 51-61 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 62-65 13678221-1 2003 A simple and versatile method for aminoacylation of a dinucleotide (pdCpA) in aqueous micellar solution was developed by using a hydrophobic amino acid derivative, N-pentenoyl-L-2-naphthylalanine cyanomethyl ester (Pen-napAla-OCM), and a CTACl micelle. Dinucleoside Phosphates 54-66 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 215-218 13678221-1 2003 A simple and versatile method for aminoacylation of a dinucleotide (pdCpA) in aqueous micellar solution was developed by using a hydrophobic amino acid derivative, N-pentenoyl-L-2-naphthylalanine cyanomethyl ester (Pen-napAla-OCM), and a CTACl micelle. 5'-phospho-2'-deoxyribocytidylylriboadenosine 68-73 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 215-218 13678221-1 2003 A simple and versatile method for aminoacylation of a dinucleotide (pdCpA) in aqueous micellar solution was developed by using a hydrophobic amino acid derivative, N-pentenoyl-L-2-naphthylalanine cyanomethyl ester (Pen-napAla-OCM), and a CTACl micelle. n-pentenoyl-l-2-naphthylalanine cyanomethyl ester 164-213 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 215-218 12801590-4 2003 Thus, two (2S)-Mdp(1)-analogues of the delta-selective cyclic enkephalin analogue H-Tyr-c[D-Pen-Gly-Phe(pF)-Pen]-Phe-OH turned out to be potent and selective delta antagonists. 2-methyl-3,3-diphenyl-3-propanolamine 10-18 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 92-95 12895574-4 2003 Secondly, the aqueous solution of a photo-reactive polymer (several nanoliters) was cast using the dip pen of the micro-spotter and dried in air. Polymers 51-58 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 103-106 12895574-9 2003 The protein-immobilized area depended on the manipulation of the micro-spotter and the size of the dip pen. 3,5-diisopropylsalicylic acid 99-102 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 31-34 12801590-4 2003 Thus, two (2S)-Mdp(1)-analogues of the delta-selective cyclic enkephalin analogue H-Tyr-c[D-Pen-Gly-Phe(pF)-Pen]-Phe-OH turned out to be potent and selective delta antagonists. 2-methyl-3,3-diphenyl-3-propanolamine 10-18 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 108-111 12801590-4 2003 Thus, two (2S)-Mdp(1)-analogues of the delta-selective cyclic enkephalin analogue H-Tyr-c[D-Pen-Gly-Phe(pF)-Pen]-Phe-OH turned out to be potent and selective delta antagonists. cyclic enkephalin 55-72 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 92-95 12801590-4 2003 Thus, two (2S)-Mdp(1)-analogues of the delta-selective cyclic enkephalin analogue H-Tyr-c[D-Pen-Gly-Phe(pF)-Pen]-Phe-OH turned out to be potent and selective delta antagonists. cyclic enkephalin 55-72 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 108-111 12660948-2 2003 All strains were characterized by multilocus sequence typing and were determined to be susceptible or intermediate resistant to penicillin (Pen(s) or Pen(i), respectively). Penicillins 128-138 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 140-143 12062658-1 2002 A pyrolysis-negative ion mass spectrometry (Pyr-NIMS) is used for the monitoring of enzymatic hydrolysis of penicillin G (Pen G) to 6-aminopenicillanic acid (6-APA) and phenyl acetic acid (PAA). pyr-nims 44-52 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 122-125 12062658-1 2002 A pyrolysis-negative ion mass spectrometry (Pyr-NIMS) is used for the monitoring of enzymatic hydrolysis of penicillin G (Pen G) to 6-aminopenicillanic acid (6-APA) and phenyl acetic acid (PAA). aminopenicillanic acid 132-156 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 122-125 12062658-1 2002 A pyrolysis-negative ion mass spectrometry (Pyr-NIMS) is used for the monitoring of enzymatic hydrolysis of penicillin G (Pen G) to 6-aminopenicillanic acid (6-APA) and phenyl acetic acid (PAA). aminopenicillanic acid 158-163 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 122-125 12062658-1 2002 A pyrolysis-negative ion mass spectrometry (Pyr-NIMS) is used for the monitoring of enzymatic hydrolysis of penicillin G (Pen G) to 6-aminopenicillanic acid (6-APA) and phenyl acetic acid (PAA). phenylacetic acid 169-187 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 122-125 12062658-1 2002 A pyrolysis-negative ion mass spectrometry (Pyr-NIMS) is used for the monitoring of enzymatic hydrolysis of penicillin G (Pen G) to 6-aminopenicillanic acid (6-APA) and phenyl acetic acid (PAA). phenylacetic acid 189-192 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 122-125 12590392-2 2003 The tapered capillary tip was coated with silver using an acrylic-based silver conductive pen. Silver 42-48 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 90-93 12062658-1 2002 A pyrolysis-negative ion mass spectrometry (Pyr-NIMS) is used for the monitoring of enzymatic hydrolysis of penicillin G (Pen G) to 6-aminopenicillanic acid (6-APA) and phenyl acetic acid (PAA). Penicillin G 108-120 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 122-125 11964171-6 2002 The Pen n 18 coding sequence was expressed in Escherichia coli as a His-tagged fusion protein and purified by Ni(2+)-chelate affinity chromatography. Nickel(2+) 110-116 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 11948446-8 2002 The model predicted the equilibrium conversion of Pen G quite reasonably for different values of pH, initial penicillin G concentration and phase volume ratio. Penicillin G 109-121 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 50-53 11952379-0 2002 Synthesis, characterization, and chiral behavior of S-bridged Co(III)Pt(II)Co(III) trinuclear complexes composed of bis(thiolato)-type octahedral units cis(S)-[Co(aet)(2)(en)](+) and/or trans(N)-[Co(D-pen- N,O,S)(2)](-) (aet = 2-aminoethanethiolate, D-pen = D-penicillaminate). co(iii)pt(ii)co(iii) 62-82 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 201-204 11952379-0 2002 Synthesis, characterization, and chiral behavior of S-bridged Co(III)Pt(II)Co(III) trinuclear complexes composed of bis(thiolato)-type octahedral units cis(S)-[Co(aet)(2)(en)](+) and/or trans(N)-[Co(D-pen- N,O,S)(2)](-) (aet = 2-aminoethanethiolate, D-pen = D-penicillaminate). co(iii)pt(ii)co(iii) 62-82 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 252-255 11435430-10 2001 Molecular modeling studies and circular dichroism analysis indicate an extended and poly-l-proline II type structural conformation for proSAAS-(235-244), the most potent PC1 inhibitor, a feature not present in poor PC1 inhibitors. polyproline 84-98 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 135-142 11955210-0 2002 Thiol diffusion and the role of humidity in "Dip Pen Nanolithography". 3,5-diisopropylsalicylic acid 45-48 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 49-52 11893850-3 2002 METHODS: In the present study, Pen ch 13 was further characterized in terms of cDNA cloning, protein purification, enzymatic activity, histamine release and IgE cross-reactivity with alkaline serine protease allergens from two other prevalent fungal species--P. citrinum (Pen c 13) and Aspergillus flavus (Asp fl 13). Histamine 135-144 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 31-34 11893850-15 2002 Basophils from 5 asthmatic patients released histamine (12-73%) when exposed to the purified Pen ch 13. Histamine 45-54 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 93-96 11893850-16 2002 In ELISA (enzyme-linked immunosorbent assay) experiments, IgE for Pen ch 13 was able to compete with purified Pen ch 13, Pen c 13 or Asp fl 13 in a dose-related manner. asp fl 13 133-142 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 66-69 11893850-16 2002 In ELISA (enzyme-linked immunosorbent assay) experiments, IgE for Pen ch 13 was able to compete with purified Pen ch 13, Pen c 13 or Asp fl 13 in a dose-related manner. asp fl 13 133-142 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 110-113 11893850-16 2002 In ELISA (enzyme-linked immunosorbent assay) experiments, IgE for Pen ch 13 was able to compete with purified Pen ch 13, Pen c 13 or Asp fl 13 in a dose-related manner. asp fl 13 133-142 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 110-113 11493062-1 2001 Dip-Pen Nanolithography (DPN) uses an AFM tip to deposit organic molecules through a meniscus onto an underlying substrate under ambient conditions. dpn 25-28 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 12545511-5 2001 The ballpoint pen ink spots were eluted in a solvent of isopropyl alcohol. 2-Propanol 56-73 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 14-17 11534617-1 2001 In situ surface-enhanced resonance Raman spectroscopy (SERRS) with excitation at 685 nm is suitable for the direct discrimination of blue and black ballpoint pen inks on paper. serrs 55-60 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 158-161 11509226-8 2001 A significant increase in errors with ethanol was seen for both maze tasks, and there was a tendency to speed up with ethanol (significant only for the pen computer task). Ethanol 118-125 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 152-155 10657731-1 1999 The biosynthesis and secretion of somatostatin (SRIH) within the hypothalamic periventricular-median eminence (PeN-ME) pathway follows a sexually differentiated developmental pattern beginning in the early neonatal period. srih 48-52 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 111-114 12203653-1 2001 Nanoscale construction work with DNA: Dip-pen nanolithography (DPN) is used to generate nanostructures which can be subsequently functionalized with oligonucleotides a" and b" and used to assemble, in an orthogonal manner, gold nanoparticles (a, b in scheme) functionalized with sequences complementary to the DPN-generated structures. dpn 63-66 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 42-45 12203653-1 2001 Nanoscale construction work with DNA: Dip-pen nanolithography (DPN) is used to generate nanostructures which can be subsequently functionalized with oligonucleotides a" and b" and used to assemble, in an orthogonal manner, gold nanoparticles (a, b in scheme) functionalized with sequences complementary to the DPN-generated structures. Oligonucleotides 149-165 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 42-45 12203653-1 2001 Nanoscale construction work with DNA: Dip-pen nanolithography (DPN) is used to generate nanostructures which can be subsequently functionalized with oligonucleotides a" and b" and used to assemble, in an orthogonal manner, gold nanoparticles (a, b in scheme) functionalized with sequences complementary to the DPN-generated structures. dpn 310-313 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 42-45 10816562-4 2000 The PC1 inhibitory region of proSAAS was mapped to an 8-12-residue region near the C terminus that includes a critical Lys-Arg sequence. Lys-Arg 119-126 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 29-36 10858308-3 2000 In contrast, the antiarthritis drug D-penicillamine, D-PEN, which differs from D-Cys only by the presence of two methyl groups on the beta-carbon, inhibits ZnCPD by promoting the release of the active-site zinc. Penicillamine 36-51 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 55-58 10858308-3 2000 In contrast, the antiarthritis drug D-penicillamine, D-PEN, which differs from D-Cys only by the presence of two methyl groups on the beta-carbon, inhibits ZnCPD by promoting the release of the active-site zinc. D-cysteine 79-84 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 55-58 10858308-3 2000 In contrast, the antiarthritis drug D-penicillamine, D-PEN, which differs from D-Cys only by the presence of two methyl groups on the beta-carbon, inhibits ZnCPD by promoting the release of the active-site zinc. Carbon 139-145 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 55-58 10858308-3 2000 In contrast, the antiarthritis drug D-penicillamine, D-PEN, which differs from D-Cys only by the presence of two methyl groups on the beta-carbon, inhibits ZnCPD by promoting the release of the active-site zinc. zncpd 156-161 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 55-58 10858308-7 2000 The interaction of D-PEN and D-Cys with the active-site metal has been examined by replacing the active-site zinc by a chromophoric cobalt atom. Metals 56-61 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 21-24 10858308-9 2000 While the D-Cys complex is stable, the CoCPD.D-PEN complex breaks down to apoenzyme and Co(D-PEN)(2) with a half-life of 0.5 s. D-PEN is the first drug found to inhibit a metalloprotease by increasing the dissociation rate constant of the active-site metal. D-cysteine 10-15 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 47-50 10858308-9 2000 While the D-Cys complex is stable, the CoCPD.D-PEN complex breaks down to apoenzyme and Co(D-PEN)(2) with a half-life of 0.5 s. D-PEN is the first drug found to inhibit a metalloprotease by increasing the dissociation rate constant of the active-site metal. D-cysteine 10-15 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 93-96 10858308-9 2000 While the D-Cys complex is stable, the CoCPD.D-PEN complex breaks down to apoenzyme and Co(D-PEN)(2) with a half-life of 0.5 s. D-PEN is the first drug found to inhibit a metalloprotease by increasing the dissociation rate constant of the active-site metal. D-cysteine 10-15 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 93-96 10858308-9 2000 While the D-Cys complex is stable, the CoCPD.D-PEN complex breaks down to apoenzyme and Co(D-PEN)(2) with a half-life of 0.5 s. D-PEN is the first drug found to inhibit a metalloprotease by increasing the dissociation rate constant of the active-site metal. Metals 171-176 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 47-50 10858308-10 2000 The ability of D-PEN to catalyze metal removal from carboxypeptidase A and other zinc proteases suggests a possible mechanism of action in arthritis and Wilson"s disease and may also underlie complications associated with its clinical use. Metals 33-38 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 17-20 10691683-1 2000 Topographically constrained analogues of the highly mu-opioid-receptor-selective antagonist CTAP (H-D-Phe-c[Cys-Tyr-D-Trp-Arg-Thr-Pen]-Thr-NH(2), 1) were prepared by solid-phase peptide synthesis. CTAP 92-96 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 130-133 10691683-1 2000 Topographically constrained analogues of the highly mu-opioid-receptor-selective antagonist CTAP (H-D-Phe-c[Cys-Tyr-D-Trp-Arg-Thr-Pen]-Thr-NH(2), 1) were prepared by solid-phase peptide synthesis. cysteinyltyrosine 108-115 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 130-133 10691683-1 2000 Topographically constrained analogues of the highly mu-opioid-receptor-selective antagonist CTAP (H-D-Phe-c[Cys-Tyr-D-Trp-Arg-Thr-Pen]-Thr-NH(2), 1) were prepared by solid-phase peptide synthesis. d-trp-arg 116-125 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 130-133 10691683-1 2000 Topographically constrained analogues of the highly mu-opioid-receptor-selective antagonist CTAP (H-D-Phe-c[Cys-Tyr-D-Trp-Arg-Thr-Pen]-Thr-NH(2), 1) were prepared by solid-phase peptide synthesis. Threonine 126-129 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 130-133 11082429-1 2000 The Phe(1) cyclic tetrapeptide Phe-c[D-Cys-Phe-D-Pen]NH(2) (Et) (JH-54) has been shown previously to exhibit high affinity and selectivity for the mu-opioid receptor. Phenylalanine 4-7 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 49-52 11082429-1 2000 The Phe(1) cyclic tetrapeptide Phe-c[D-Cys-Phe-D-Pen]NH(2) (Et) (JH-54) has been shown previously to exhibit high affinity and selectivity for the mu-opioid receptor. Phenylalanine 31-34 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 49-52 11082429-3 2000 Alteration of the bridging groups between the D-Cys(2) and D-Pen(4) residues of JH-54 from dithioether to disulfide revealed the importance of the relative position of the aromatic rings of the first and third residues in determining mu- and delta-affinities. juvenile hormone III 80-82 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 61-64 11082429-3 2000 Alteration of the bridging groups between the D-Cys(2) and D-Pen(4) residues of JH-54 from dithioether to disulfide revealed the importance of the relative position of the aromatic rings of the first and third residues in determining mu- and delta-affinities. dithioether 91-102 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 61-64 11082429-3 2000 Alteration of the bridging groups between the D-Cys(2) and D-Pen(4) residues of JH-54 from dithioether to disulfide revealed the importance of the relative position of the aromatic rings of the first and third residues in determining mu- and delta-affinities. Disulfides 106-115 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 61-64 10852254-1 2000 OBJECTIVE: To investigate the mechanism of autoimmune phenomena, occasionally seen in patients with rheumatoid arthritis treated with bucillamine (BUC) and D-penicillamine (D-Pen), by evaluating their effects on apoptosis of T cells induced by T cell receptor activation or dexamethasone. Penicillamine 156-171 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 175-178 10727108-7 2000 Lastly, we have identified a peptide, D-Hat-c[D-Cys-Phe-D-Pen]NH2 (Et), with high potency and > 1,000-fold functional selectivity for the mu over delta opioid receptor as measured by the [35S]-GTPgammaS assay. Cysteine 48-51 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 58-61 10727108-7 2000 Lastly, we have identified a peptide, D-Hat-c[D-Cys-Phe-D-Pen]NH2 (Et), with high potency and > 1,000-fold functional selectivity for the mu over delta opioid receptor as measured by the [35S]-GTPgammaS assay. Sulfur-35 191-194 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 58-61 10657731-4 1999 Using an in vitro hypothalamic preparation where more than 97% of the immunoreactive SRIH is contained within the PeN-ME pathway, peptide release in response to the GABA(A) receptor antagonist, bicuculline, was followed through development. srih 85-89 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 114-117 10521346-1 1999 A scanning probe method, dip-pen nanolithography (DPN), can be used to pattern monolayers of different organic molecules down to a 5-nanometer separation. dpn 50-53 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 29-32 10555917-1 1999 A 66-year-old Japanese woman with severe scleroderma developed anemia and thrombocytopenia due to D-penicillamine (D-Pen) treatment, although the leukopenia was not markedly severe. Penicillamine 98-113 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 117-120 10366112-1 1999 OBJECTIVE: To test the hypothesis that systemic sclerosis (SSc) patients taking high-dose D-penicillamine (D-Pen) would have greater softening of skin, lower frequency of renal crisis, and better survival than patients taking low-dose D-Pen. Penicillamine 90-105 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 109-112 15822268-0 1999 [Study on the inkblot of carbon pen fields by Raman micro-spectroscopy]. Carbon 25-31 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 32-35 15822268-1 1999 The four carbon-pen inkblots in market were studied by Raman micro-spectroscopy. Carbon 9-15 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 16-19 10520960-0 1999 Isolation and analysis of a novel acidic polysaccharide from the case of squid pen. Polysaccharides 41-55 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 79-82 10520960-1 1999 A new non-sulphated acidic polysaccharide with an average molecular mass of 55 kDa was isolated from squid pen case after papain digestion and beta-elimination. Polysaccharides 27-41 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 107-110 10366112-1 1999 OBJECTIVE: To test the hypothesis that systemic sclerosis (SSc) patients taking high-dose D-penicillamine (D-Pen) would have greater softening of skin, lower frequency of renal crisis, and better survival than patients taking low-dose D-Pen. Penicillamine 90-105 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 237-240 10381063-2 1999 We describe 3 patients with accelerated nodulosis treated with D-penicillamine (D-Pen) while continuing MTX. Penicillamine 63-78 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 82-85 10103041-3 1999 The protein, designated Pen c 1, was purified by sequential DEAE-Sepharose and carboxymethyl (CM)-Sepharose chromatographies. deae-sepharose 60-74 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 24-27 10103041-3 1999 The protein, designated Pen c 1, was purified by sequential DEAE-Sepharose and carboxymethyl (CM)-Sepharose chromatographies. carboxymethyl-coenzyme A 79-92 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 24-27 10103041-3 1999 The protein, designated Pen c 1, was purified by sequential DEAE-Sepharose and carboxymethyl (CM)-Sepharose chromatographies. Sepharose 65-74 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 24-27 10103041-8 1999 Pen c 1 codes for a larger precursor containing a signal peptide, a propeptide and the 33-kDa mature protein. Peptides 57-64 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 0-3 10103041-8 1999 Pen c 1 codes for a larger precursor containing a signal peptide, a propeptide and the 33-kDa mature protein. propeptide 68-78 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 0-3 10103041-12 1999 The allergen encoded by Pen c 1 gene was expressed in Escherichia coli as a fusion protein bearing an N-terminal histidine-affinity tag. Histidine 113-122 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 24-27 10069885-3 1999 OBJECTIVE: The purpose of this study was to evaluate the measurement by enzyme immunoassay of extracellular polysaccharides of Aspergillus and Penicillium species (EPS-Asp/Pen ) in house dust as a marker for fungal exposure and to study the relations between EPS-Asp/Pen levels and home dampness and respiratory symptoms in children. Polysaccharides 108-123 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 172-175 10217714-0 1999 Malayenolides A-D, novel diterpenes from the indonesian sea pen veretillum malayense Malayenolides A-D (1-4), four new briarane diterpenes, were isolated from the sea pen Veretillum malayense collected in Indonesia. malayenolides a-d 0-17 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 30-33 10217714-0 1999 Malayenolides A-D, novel diterpenes from the indonesian sea pen veretillum malayense Malayenolides A-D (1-4), four new briarane diterpenes, were isolated from the sea pen Veretillum malayense collected in Indonesia. malayenolides a-d 0-17 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 61-64 10198852-9 1999 Mean Tono-Pen IOP in steroid-treated post-PRK eyes was 4.3 +/- 3 mm Hg higher than in the fellow eyes (P = .0014); mean GAT IOP was only 2.3 +/- 3.5 mm Hg higher (P = .04). Steroids 21-28 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 10-13 10069885-3 1999 OBJECTIVE: The purpose of this study was to evaluate the measurement by enzyme immunoassay of extracellular polysaccharides of Aspergillus and Penicillium species (EPS-Asp/Pen ) in house dust as a marker for fungal exposure and to study the relations between EPS-Asp/Pen levels and home dampness and respiratory symptoms in children. eps-asp 164-171 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 143-146 10069885-3 1999 OBJECTIVE: The purpose of this study was to evaluate the measurement by enzyme immunoassay of extracellular polysaccharides of Aspergillus and Penicillium species (EPS-Asp/Pen ) in house dust as a marker for fungal exposure and to study the relations between EPS-Asp/Pen levels and home dampness and respiratory symptoms in children. exophthalmos producing substance 164-167 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 143-146 10069885-3 1999 OBJECTIVE: The purpose of this study was to evaluate the measurement by enzyme immunoassay of extracellular polysaccharides of Aspergillus and Penicillium species (EPS-Asp/Pen ) in house dust as a marker for fungal exposure and to study the relations between EPS-Asp/Pen levels and home dampness and respiratory symptoms in children. Aspartic Acid 127-130 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 172-175 10069885-5 1999 RESULTS: EPS-Asp/Pen were readily detectable (40 to 46,513 nanogram equivalent/g dust) in 161 house dust extracts, with highest concentrations in living room floor dust. exophthalmos producing substance 9-12 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 17-20 10069885-6 1999 EPS-Asp/Pen levels were 2 to 3 times higher on carpeted floors than on smooth floors. exophthalmos producing substance 0-3 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 8-11 10069885-8 1999 EPS-Asp/Pen levels in living room floor dust were positively associated with occupant-reported home dampness. exophthalmos producing substance 0-3 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 8-11 10069885-10 1999 EPS-Asp/Pen levels in living room floor dust were positively associated with respiratory symptoms. exophthalmos producing substance 0-3 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 8-11 10069885-11 1999 EPS-Asp/Pen in bedroom floor and mattress dust showed a reversed association with respiratory symptoms, possibly because of allergen-avoidance measures taken in the bedroom. exophthalmos producing substance 0-3 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 8-11 10069885-12 1999 CONCLUSION: The enzyme immunoassay for fungal EPS-Asp/Pen may be a useful method for exposure assessment of indoor fungi. eps-asp 46-53 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 54-57 8756510-2 1996 Residue 3 dehydrophenylalanine analogues of Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13) confirm required gauche orientation of aromatic side chain. phenyldehydroalanine 10-30 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 62-65 9916749-3 1999 When PBMC of donors suffering from hypersensitivity reactions against beta-lactams were stimulated in vitro with different doses of Pen G, a preferential expansion of IL-4-producing TCR alphabeta+ cells was detected. beta-Lactams 70-82 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 132-135 9511860-3 1998 In our studies, capillary electrophoresis (CE) was used for the analysis of water-soluble fountain pen inks. Water 76-81 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 99-102 9241694-3 1997 A levelling bulb with water mounted on the pen transmits the pressure adjustments to the KOH solution through a water filled tubing. Water 22-27 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 43-46 9241694-3 1997 A levelling bulb with water mounted on the pen transmits the pressure adjustments to the KOH solution through a water filled tubing. potassium hydroxide 89-92 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 43-46 9241694-3 1997 A levelling bulb with water mounted on the pen transmits the pressure adjustments to the KOH solution through a water filled tubing. Water 112-117 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 43-46 9041177-3 1997 Previous studies identified 4-demethylpenclomedine (4-DM-PEN) as the major plasma metabolite in rodents and humans. 4-demethylpenclomedine 28-50 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 57-60 9041177-4 1997 4-DM-PEN was demonstrated to be an antitumor-active metabolite of penclomedine in vivo when evaluated against the penclomedine-sensitive MX-1 human breast tumor xenograft implanted either s.c. or intracerebrally and is believed to be on the metabolic activation pathway of penclomedine. penclomedine 66-78 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 5-8 9041177-4 1997 4-DM-PEN was demonstrated to be an antitumor-active metabolite of penclomedine in vivo when evaluated against the penclomedine-sensitive MX-1 human breast tumor xenograft implanted either s.c. or intracerebrally and is believed to be on the metabolic activation pathway of penclomedine. penclomedine 114-126 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 5-8 9041177-4 1997 4-DM-PEN was demonstrated to be an antitumor-active metabolite of penclomedine in vivo when evaluated against the penclomedine-sensitive MX-1 human breast tumor xenograft implanted either s.c. or intracerebrally and is believed to be on the metabolic activation pathway of penclomedine. penclomedine 114-126 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 5-8 9574332-2 1997 In a prospective randomised trial, a new automatic pen for subcutaneous injections of low molecular heparin was studied with 489 injections in 51 patients. Heparin 100-107 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 51-54 9574332-3 1997 The automatic pen with a covered needle allows a safe and standardised subcutaneous administration of low-molecular heparin with good patient comfort and at no additional costs. Heparin 116-123 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 14-17 9987254-6 1998 However, because inadvertent exposure to latex is not uncommon, Medic-Alert bracelets and an Epi-Pen should be provided for children allergic to latex. Latex 145-150 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 97-100 9595865-6 1998 They were given a Glaxo-Pen with two sumatriptan refills to take with them for treating their own migraine attacks. Sumatriptan 37-48 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 24-27 9359588-2 1997 Opioid agonists selective for either mu (Tyr-D-Ala-Gly-Mephe-Gly-ol; DAMGO) or delta (Tyr-D-Pen-Gly-Phe-D-Pen-OH; DPDPE) receptors inhibited high-threshold Ba2+ currents. Phenylalanine 100-103 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 92-95 9095309-5 1997 Another notable feature of the case was an atypical entrance wound due to the 0.25 caliber Winchester AXP ammunition that the pen gun fired. 4-ACETAMIDO-2,4-DIDEXOY-D-GLYCERO-BETA-D-GALACTO-OCTOPYRANOSYLPHOSPHONIC ACID (AN AXIAL PHOSPHONATE) 102-105 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 126-129 8957332-0 1996 Triethanolamine allergy inadvertently discovered from a fluorescent marking pen. triethanolamine 0-15 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 76-79 8957332-2 1996 We report a case of a woman with a contact allergy to triethanolamine inadvertently discovered when she had a reaction to a triethanolamine-containing fluorescent marking pen that was used in patch testing. triethanolamine 54-69 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 171-174 8957332-2 1996 We report a case of a woman with a contact allergy to triethanolamine inadvertently discovered when she had a reaction to a triethanolamine-containing fluorescent marking pen that was used in patch testing. triethanolamine 124-139 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 171-174 8756510-3 1996 We have previously proposed a model for the delta-opioid receptor binding conformation of the high affinity tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13) based on experimental and theoretical conformational analysis of this peptide and a correlation of conformational preferences of further conformationally restricted analogues of this tetrapeptide with their receptor binding affinities. Tyrosine 121-124 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 139-142 7578939-2 1995 Two kinds of peptides were designed, namely, the cyclic peptides of the H-Tyr-cyclo (D-Pen-Gly-Trp-L/D-3-transmercaptoproline)-Asp-Phe-NH2 sequence (compounds 1a and 1b, respectively), and the linear peptides of the H-Tyr-D-Val-Gly-Trp-L/D-3-trans-methylmercaptoproline-Asp-Phe- NH2 sequence (compounds 2a and 2b, respectively). h-tyr-cyclo 72-83 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 87-90 8730113-10 1996 From a societal perspective, the incremental cost of CyA was $2,886 and $3,731 between Aza and D-Pen, respectively. Cyclosporine 53-56 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 97-100 8589255-2 1996 We have previously proposed a model of the delta-opioid receptor bound conformation for the cyclic tetrapeptide, Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13) based on its conformational analysis and from conformation-affinity relationships observed for its analogues with modified first and third residues. Tyrosine 113-116 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 131-134 9095246-3 1996 Pen a 1, purified by preparative SDS-PAGE and commercially obtained porcine, bovine and rabbit tropomyosin were cleaved by CNBr or digested by endoproteinases Lys-C, Glu-C, trypsin, Arg-C and chymotrypsin. Sodium Dodecyl Sulfate 33-36 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 0-3 8759396-7 1996 Ana-guard injector is recommended for the allergic adult due to its easy handling and the fact that it contains two doses of adrenaline 0.3 mg. For both children and adults with a low bodyweight, the Epi-Pen automatic injector is recommended. Epinephrine 125-135 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 204-207 7578939-2 1995 Two kinds of peptides were designed, namely, the cyclic peptides of the H-Tyr-cyclo (D-Pen-Gly-Trp-L/D-3-transmercaptoproline)-Asp-Phe-NH2 sequence (compounds 1a and 1b, respectively), and the linear peptides of the H-Tyr-D-Val-Gly-Trp-L/D-3-trans-methylmercaptoproline-Asp-Phe- NH2 sequence (compounds 2a and 2b, respectively). l 99-100 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 87-90 7578939-2 1995 Two kinds of peptides were designed, namely, the cyclic peptides of the H-Tyr-cyclo (D-Pen-Gly-Trp-L/D-3-transmercaptoproline)-Asp-Phe-NH2 sequence (compounds 1a and 1b, respectively), and the linear peptides of the H-Tyr-D-Val-Gly-Trp-L/D-3-trans-methylmercaptoproline-Asp-Phe- NH2 sequence (compounds 2a and 2b, respectively). Deuterium 85-86 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 87-90 7578939-2 1995 Two kinds of peptides were designed, namely, the cyclic peptides of the H-Tyr-cyclo (D-Pen-Gly-Trp-L/D-3-transmercaptoproline)-Asp-Phe-NH2 sequence (compounds 1a and 1b, respectively), and the linear peptides of the H-Tyr-D-Val-Gly-Trp-L/D-3-trans-methylmercaptoproline-Asp-Phe- NH2 sequence (compounds 2a and 2b, respectively). h-tyr-d-val-gly-trp 216-235 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 87-90 7578939-2 1995 Two kinds of peptides were designed, namely, the cyclic peptides of the H-Tyr-cyclo (D-Pen-Gly-Trp-L/D-3-transmercaptoproline)-Asp-Phe-NH2 sequence (compounds 1a and 1b, respectively), and the linear peptides of the H-Tyr-D-Val-Gly-Trp-L/D-3-trans-methylmercaptoproline-Asp-Phe- NH2 sequence (compounds 2a and 2b, respectively). trans-methylmercaptoproline 242-269 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 87-90 7578939-2 1995 Two kinds of peptides were designed, namely, the cyclic peptides of the H-Tyr-cyclo (D-Pen-Gly-Trp-L/D-3-transmercaptoproline)-Asp-Phe-NH2 sequence (compounds 1a and 1b, respectively), and the linear peptides of the H-Tyr-D-Val-Gly-Trp-L/D-3-trans-methylmercaptoproline-Asp-Phe- NH2 sequence (compounds 2a and 2b, respectively). asp-phe- nh2 270-282 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 87-90 7608665-0 1995 Pen injected apomorphine against off phenomena in late Parkinson"s disease: a double blind, placebo controlled study. Apomorphine 13-24 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 0-3 8529495-7 1995 Blood glucose profiles were similar during both treatment modalities except for pre-lunch blood glucose values (mmol/l) lower during pen treatment (8.7 +/- 2.9 vs. 9.2 +/- 2.7, P < 0.01). Blood Glucose 90-103 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 133-136 7654064-4 1995 The PEN O:4/59 serotype, isolated from the stools of a Guillain-Barre syndrome patient, inhibited 63 to 93% of the anti-GM1 activity in 6 of 11 patients. G(M1) Ganglioside 120-123 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 7654064-5 1995 The PEN O:41 inhibited 63 to 100% of the anti-GM1 antibody activity in 9 of 11 patients. G(M1) Ganglioside 46-49 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 7654064-6 1995 The PEN O:22 inhibited anti-GM1 antibody activity in only 2 of 11 patients (80 and 86%). G(M1) Ganglioside 28-31 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 4-7 7586781-1 1995 OBJECTIVE: We have previously shown that the administration of D-penicillamine (D-PEN) to patients with rheumatoid arthritis induces circulating insulin autoantibodies (INSAAB). Penicillamine 63-78 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 82-85 7608665-1 1995 The effect, therapeutic dose range, and pharmacokinetics of apomorphine, given as subcutaneous injections by a single use pen, were evaluated in the treatment of off phenomena in 22 patients with idiopathic Parkinson"s disease. Apomorphine 60-71 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 122-125 7608665-10 1995 It is concluded that pen injected apomorphine is a valuable treatment for patients with advanced Parkinson"s disease with on-off phenomena. Apomorphine 34-45 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 21-24 8151486-5 1994 The mean CSF penicillin concentration among the 63 infants treated with either of the A-PEN regimens (0.465 microgram/ml) was significantly greater than the mean concentration (0.077 microgram/ml) among those treated with P-PEN (p < 0.001). Penicillins 13-23 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 88-91 7821007-1 1994 2-hydroxy-5-tert-butyl benzylalcohol and 2,6-bis(hydroxymethyl)-4-tert-butylphenol were identified as contact allergens in a phenolic resin used as a tackifier in the ink of a marking pen, which, after being used directly on the skin, caused an acute contact dermatitis on the hand of a 13-year-old boy. 2-hydroxy-5-tert-butylbenzyl alcohol 0-36 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 184-187 7821007-1 1994 2-hydroxy-5-tert-butyl benzylalcohol and 2,6-bis(hydroxymethyl)-4-tert-butylphenol were identified as contact allergens in a phenolic resin used as a tackifier in the ink of a marking pen, which, after being used directly on the skin, caused an acute contact dermatitis on the hand of a 13-year-old boy. 2,6-bis(hydroxymethyl)-4-tert-butylphenol 41-82 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 184-187 7896499-7 1994 In general, these trends mirror those observed for similar modification in Tyr-c[D-Cys-Phe-D-Pen]. Tyrosine 75-78 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 93-96 7896500-3 1994 This paper investigates the effect of the addition of a phenylalanine residue on the RGD conformation in cyclo(1,6)Ac-Cys-Arg-Gly-Asp-Phe-Pen-NH2 (1) as compared to the previously studied cyclo(1,5)Ac-Pen-Arg-Gly-Asp-Cys-NH2 (2). Phenylalanine 56-69 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 138-141 7896500-3 1994 This paper investigates the effect of the addition of a phenylalanine residue on the RGD conformation in cyclo(1,6)Ac-Cys-Arg-Gly-Asp-Phe-Pen-NH2 (1) as compared to the previously studied cyclo(1,5)Ac-Pen-Arg-Gly-Asp-Cys-NH2 (2). Phenylalanine 56-69 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 201-204 7930306-4 1994 Benzylpenicilloyl-polylysine (Pre-Pen) and fresh penicillin G are used for skin testing by more than 86% of both respondent groups, whereas minor determinant mixtures are used by only 40%. penicilloyl polylysine 0-28 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 34-37 7799341-1 1994 OBJECTIVE: To determine whether intermittent rather than daily administration of D-penicillamine (D-Pen) would effectively reduce the incidence of adverse effects without significantly diminishing the clinical benefits. Penicillamine 81-96 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 100-103 8151486-8 1994 However, 33.3% (9/27) of specimens from infants who received P-PEN, tested between 18 and 24 hours after a dose, had CSF penicillin concentrations < 0.018 microgram/ml. Penicillins 121-131 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 63-66 8041003-5 1994 We conclude that PPNG as well as other penicillin resistant strains (Pen RB Neg) of neisseria gonorrhea are prevalent in our country and appropriate changes in the conventional therapeutic regime are desirable. Penicillins 39-49 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 69-72 8145226-1 1994 Structure-activity studies have been pursued on cyclo-S,S-[Ac-Cys-(N alpha-Me)Arg-Gly-Asp-Pen]-NH2, 2 (SK&F 106760), a potent inhibitor of platelet aggregation, in an effort to improve potency and affinity for the GPIIb/IIIa receptor. emodepside 48-55 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 90-93 8145226-1 1994 Structure-activity studies have been pursued on cyclo-S,S-[Ac-Cys-(N alpha-Me)Arg-Gly-Asp-Pen]-NH2, 2 (SK&F 106760), a potent inhibitor of platelet aggregation, in an effort to improve potency and affinity for the GPIIb/IIIa receptor. Adenosine Monophosphate 106-109 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 90-93 18615694-3 1994 The SLM system in this study proved to be a promising process for the selective separation of Pen G from PAA. phenylacetic acid 105-108 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 94-97 7746886-8 1994 After 3 months of the pen use the mean levels of glucose were lower as well as the level of HbA1c. Glucose 49-56 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 22-25 18615694-1 1994 The separation of penicillin G (Pen G) from phenylacetic acid (PAA) by use of a supported liquid membrane (SLM) system with Amberlite LA-2 dissolved in 1-decanol, supported on a microporous polypropylene membrane, was studied. Penicillin G 18-30 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 32-35 8216554-10 1993 In addition, once the patient develops a positive IPT, Pen G residue on the testing site should be wiped away rapidly and washed out with cool water thoroughly to disrupt further violent reaction. isoprothiolane 50-53 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 55-58 18965799-2 1993 The chemical equilibria involved in nine mixed ligand systems Zn(II)-L-cysteine (Cys)/D-penicillamine(Pen)/L-cysteic acid(Cya)(A)-imidazole(Him), histamine(Hist) and L-histidine(His)(B) have been investigated in aqueous perchlorate medium by pH titrimetry at 37 degrees and ionic strength, I = 0.15M (NaClO(4)). Penicillamine 86-101 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 102-105 8216554-7 1993 The results of skin tests in these patients showed that IPT with 500 U/ml of Pen G was not only reliable but also safe. isoprothiolane 56-59 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 77-80 8475703-6 1993 The Tono-Pen was agreeable both to patients and physicians. tono 4-8 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 9-12 8461340-0 1993 Charge-remote fragmentation in a disulfide-containing peptide, [Pen]-enkephalin, under fast atom bombardment collisionally activated dissociation conditions. Disulfides 33-42 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 64-67 8461340-1 1993 Fast atom bombardment collisionally activated dissociation tandem mass spectrometry (FAB CAD MS/MS) of a disulfide-containing peptide, [2-D-penicillamine, 5-D-penicillamine]- enkephalin ([Pen]-enkephalin), is described. Disulfides 105-114 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 188-191 8461340-1 1993 Fast atom bombardment collisionally activated dissociation tandem mass spectrometry (FAB CAD MS/MS) of a disulfide-containing peptide, [2-D-penicillamine, 5-D-penicillamine]- enkephalin ([Pen]-enkephalin), is described. Peptides 126-133 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 188-191 8461340-1 1993 Fast atom bombardment collisionally activated dissociation tandem mass spectrometry (FAB CAD MS/MS) of a disulfide-containing peptide, [2-D-penicillamine, 5-D-penicillamine]- enkephalin ([Pen]-enkephalin), is described. 5-d-penicillamine]- enkephalin 155-185 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 188-191 8461340-2 1993 Unlike those of most other disulfide-containing peptides investigated, CAD of the native, unreduced protonated molecule of [Pen]-enkephalin yields a relatively large number of fragment ions. Disulfides 27-36 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 124-127 8461340-7 1993 Comparison of the CAD spectra of derivatized and underivatized [Pen]-enkephalin suggests that charge-remote fragmentation plays a significant role in the high-energy dissociation of this disulfide-bonded peptide. Disulfides 187-196 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 64-67 8337118-10 1993 HPA-4 (Pen, Yuk) as HPA1 is on GPIIIa but in a different location (Arg<==>Gln 143). Arginine 67-70 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 7-10 8337118-10 1993 HPA-4 (Pen, Yuk) as HPA1 is on GPIIIa but in a different location (Arg<==>Gln 143). Glutamine 80-83 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 7-10 1530602-0 1992 Conformational study of cyclo(1,5)-Ac-Pen-Arg-Gly-Asp-Cys-NH2 in water by NMR and molecular dynamics. Water 65-70 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 38-41 1582389-5 1992 Although the peak urinary levels of procaine occurred between 30 mins and 6 h, detection in urine in most cases was as long as 78-120 h except for Diathal for which detection was limited to 54 h. Daily administration of a penicillin G-procaine preparation (Pen-Di-Strep) for 5 days produced a biphasic peak in plasma procaine at 3 and at 6-9 h with detection from 16 to 23 h after drug treatment. Procaine 235-243 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 257-260 1410736-0 1992 [Experience with the Du Pen epidural catheter in chronic cancer pain]. du 21-23 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 24-27 1410736-1 1992 We evaluate the results obtained with the use of Du Pen"s epidural catheter in a series of patients with chronic oncologic pain. du 49-51 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 52-55 1580809-3 1992 The speed and the quality of motor response and the pharmacokinetic profile showed results similar to those seen after subcutaneous injection of apomorphine administered by insulin pen syringe. Apomorphine 145-156 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 181-184 1582389-5 1992 Although the peak urinary levels of procaine occurred between 30 mins and 6 h, detection in urine in most cases was as long as 78-120 h except for Diathal for which detection was limited to 54 h. Daily administration of a penicillin G-procaine preparation (Pen-Di-Strep) for 5 days produced a biphasic peak in plasma procaine at 3 and at 6-9 h with detection from 16 to 23 h after drug treatment. Penicillin G 222-234 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 257-260 1582389-5 1992 Although the peak urinary levels of procaine occurred between 30 mins and 6 h, detection in urine in most cases was as long as 78-120 h except for Diathal for which detection was limited to 54 h. Daily administration of a penicillin G-procaine preparation (Pen-Di-Strep) for 5 days produced a biphasic peak in plasma procaine at 3 and at 6-9 h with detection from 16 to 23 h after drug treatment. Procaine 235-243 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 257-260 1338161-4 1992 PEN patients demonstrated segmental vegetative disorders that manifested by reduced conduction in sweating fibers (a method of evoked cutaneous sympathetic potentials), a lowering of sympathetic effects in the cardiovascular system, a decline of diurnal excretion of catecholamines. Catecholamines 267-281 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 0-3 1667926-6 1991 Only class III conformers for both c-ORN and c-PEN, having tyramine dihedral angles chi 1 = 150 degrees +/- 30 degrees and chi 2 = -155 degrees +/- 20 degrees, had significant structural and conformational properties that were mutually compatible while respecting the PEO vector space. Tyramine 59-67 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 47-50 1676628-1 1991 D-penicillamine (D-PEN) is incompletely recovered during short-term balance studies, despite rapid elimination of D-PEN and its low molecular weight metabolites. Penicillamine 0-15 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 19-22 1886858-12 1991 Hatch of fertile eggs, overall hatchability, and the number of chicks per pen were all significantly improved by 27.5 mg/kg of zinc bacitracin. Bacitracin 127-142 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 74-77 1917296-3 1991 A variety of procedures have been demonstrated using the related model peptides Ac-Cys-Pro-D Val-Cys-NH2 and Ac-Pen-Pro-D Val-Cys-NH2 (which both readily assume a type II beta-turn conformation that becomes stabilized by a 14-membered disulfide-containing intramolecular ring), and oxytocin (conformationally mobile 20-membered disulfide ring). val-cys-nh2 122-133 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 112-115 1917296-3 1991 A variety of procedures have been demonstrated using the related model peptides Ac-Cys-Pro-D Val-Cys-NH2 and Ac-Pen-Pro-D Val-Cys-NH2 (which both readily assume a type II beta-turn conformation that becomes stabilized by a 14-membered disulfide-containing intramolecular ring), and oxytocin (conformationally mobile 20-membered disulfide ring). Disulfides 235-244 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 112-115 1917296-3 1991 A variety of procedures have been demonstrated using the related model peptides Ac-Cys-Pro-D Val-Cys-NH2 and Ac-Pen-Pro-D Val-Cys-NH2 (which both readily assume a type II beta-turn conformation that becomes stabilized by a 14-membered disulfide-containing intramolecular ring), and oxytocin (conformationally mobile 20-membered disulfide ring). Disulfides 328-337 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 112-115 1654306-5 1991 These sets of structures were compared for geometrical similarity between themselves and with the low-energy conformations found for the delta-selective peptide Tyr-D-Cys-Phe-D-Pen-OH and nonactive peptide Tyr-Orn-Phe-Asp-NH2. tyr-d-cys 161-170 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 177-180 1654306-5 1991 These sets of structures were compared for geometrical similarity between themselves and with the low-energy conformations found for the delta-selective peptide Tyr-D-Cys-Phe-D-Pen-OH and nonactive peptide Tyr-Orn-Phe-Asp-NH2. Phenylalanine 171-174 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 177-180 1654306-5 1991 These sets of structures were compared for geometrical similarity between themselves and with the low-energy conformations found for the delta-selective peptide Tyr-D-Cys-Phe-D-Pen-OH and nonactive peptide Tyr-Orn-Phe-Asp-NH2. Deuterium 165-166 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 177-180 1654306-5 1991 These sets of structures were compared for geometrical similarity between themselves and with the low-energy conformations found for the delta-selective peptide Tyr-D-Cys-Phe-D-Pen-OH and nonactive peptide Tyr-Orn-Phe-Asp-NH2. Tyrosine 161-164 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 177-180 1872124-0 1991 Octreotide treatment in acromegaly: a comparison between pen-treated and pump-treated patients in a cross-over study. Octreotide 0-10 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 57-60 1872124-1 1991 The effect of a schedule of three daily injections of 100 micrograms octreotide (pen treatment) compared with that of a continuous sc infusion of 300 micrograms/24 h on GH and IGF-I suppression, and other GH-dependent parameters was studied in 10 acromegalic patients in a cross-over study. Octreotide 69-79 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 81-84 1676628-3 1991 A study was performed to determine whether the formation and later breakdown of a stable disulfide between D-PEN and plasma albumin could explain these aspects of D-PEN pharmacokinetics. Disulfides 89-98 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 109-112 1676628-3 1991 A study was performed to determine whether the formation and later breakdown of a stable disulfide between D-PEN and plasma albumin could explain these aspects of D-PEN pharmacokinetics. Disulfides 89-98 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 165-168 1676628-5 1991 Plasma concentration-time profiles for D-PEN and D-PEN-albumin disulfide (D-PEN-albumin) were determined during the first day and pre-dose concentrations were measured on five further occasions. Deuterium 39-40 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 41-44 2086280-3 1990 The aim of the french multicentric study is to estimate the clinical interest of a new insulin-pen (Optipen-Hoechst) with two main characteristics: the ability of a predetermination of the insulin dosage to be administered and the suitability for both regular, intermediate and pre-mixed regular (25%) and intermediate (75%) Hoechst insulin preparations. optipen-hoechst 100-115 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 95-98 2093440-1 1990 D-Pen represents an effective treatment for a proportion of patients with RA and PSS. Radium 74-76 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 2-5 1925086-3 1991 These results suggest that the Oculab Tono-Pen is an effective instrument with which to measure intraocular pressure in silicone-filled eye. Silicones 120-128 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 43-46 2086280-3 1990 The aim of the french multicentric study is to estimate the clinical interest of a new insulin-pen (Optipen-Hoechst) with two main characteristics: the ability of a predetermination of the insulin dosage to be administered and the suitability for both regular, intermediate and pre-mixed regular (25%) and intermediate (75%) Hoechst insulin preparations. hoechst 108-115 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 95-98 2376469-3 1990 Treatment of the protected peptides Ac-L-Pen(X)-L-Pro-D-Val-L-Cys(X)-NH2 with thallium (III) trifluoroacetate or iodine for X = Acm or piperidine/DMF (1:1) for X = Fm induced with good yield the formation of the intramolecular disulfide bridge. Peptides 27-35 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 41-44 2115686-9 1990 The combination of glibenclamide and insulin (administered with the Novo Pen injector) is a safe and effective form of therapy in secondary failure of sulfonylurea, and is well accepted due to the mild start into insulin therapy. Glyburide 19-32 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 73-76 2354430-0 1990 Chronic cancer pain management with the Du Pen epidural catheter. du 40-42 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 43-46 2354430-2 1990 The Du Pen epidural catheter (Davol, Inc.) a silicone-based tunneled catheter modeled after the Hickman central venous catheter, has provided a safe, reliable means of long-term administration of drugs to the epidural space in over 400 patients to date. Silicones 45-53 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 7-10 2376469-3 1990 Treatment of the protected peptides Ac-L-Pen(X)-L-Pro-D-Val-L-Cys(X)-NH2 with thallium (III) trifluoroacetate or iodine for X = Acm or piperidine/DMF (1:1) for X = Fm induced with good yield the formation of the intramolecular disulfide bridge. Thallium 78-86 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 41-44 2376469-3 1990 Treatment of the protected peptides Ac-L-Pen(X)-L-Pro-D-Val-L-Cys(X)-NH2 with thallium (III) trifluoroacetate or iodine for X = Acm or piperidine/DMF (1:1) for X = Fm induced with good yield the formation of the intramolecular disulfide bridge. Trifluoroacetic Acid 93-109 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 41-44 2305223-0 1990 [Evaluation of Pen meters for blood glucose analysis in ambulatory diabetics]. Blood Glucose 30-43 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 15-18 2305223-1 1990 A recently developed pen-sized glucose meter using direct electrochemistry to give an automatic digital readout of the blood glucose concentration was evaluated in 10 diabetic outpatients using it at home for 8 weeks. Glucose 31-38 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 21-24 2305223-5 1990 Patients" replies to a questionnaire revealed that all welcomed the pen-meter as a fast, easy to use and highly portable device for self monitoring of blood glucose. Blood Glucose 151-164 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 68-71 2112569-2 1990 Since many patients previously studied were on Gold Sodium Thiomalate (GST), Auranofin (Auf), or D-Penicillamine (D-Pen) we have investigated the effects of these drugs on IFN gamma production using PBMC from normal controls (NC), and RA patients off GST, Auf, and D-Pen. Penicillamine 97-112 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 116-119 34524010-1 2022 OBJECTIVE: This study used connected pen to determine missed bolus dose (MBD) frequency during masked and unmasked continuous glucose monitoring (CGM) periods and examined its link with time-in-range (TIR), time-above-range (TAR), time-below-range (TBR), and key participant characteristics in people with diabetes. Glucose 126-133 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 37-40 33587519-11 2021 The Tono-Pen showed clinically acceptable agreement with GAT in control eyes and poor agreement in PKP eyes. gat 57-60 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 9-12 34271183-2 2022 A recent study has proposed a clinical decision rule, PEN-FAST, to identify low-risk penicillin allergies. Penicillins 85-95 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 54-57 34542865-8 2021 Reasons were consistent with IL200 features, explaining the better patient experience and potential resource saving transitioning from a disposable MTI-100 pen. mti-100 148-155 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 156-159 34940015-6 2021 The augmenting effect of AgNPs used to increase the surface plasmon resonance signal response was examined using polymer-based PEN-G imprinted (MIPs) sensor without the addition of AgNPs. agnps 25-30 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 127-130 34709261-4 2021 The lowest WVTR value measured was 1.28 x 10-5 g m-2 day-1 for the O2 plasma pre-treated PEN substrate coated with 100 ALI cycles, which improved 3-4 orders of magnitude compared to that of the pristine ones. Oxygen 67-69 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 89-92 34709261-5 2021 Besides, the infiltrated PEN substrate with O2 plasma pre-treatment exhibited good mechanical stability, with only a slight increase of the WVTR value which was observed after the bending fatigue test with a radius of 5 mm. Oxygen 44-46 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 25-28 34913792-0 2022 Device Development for Biosimilars: Human Factor Engineering for a Teriparatide Pen. Teriparatide 67-79 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 80-83 34913792-1 2022 BACKGROUND: A thorough Human Factors Engineering (HFE) process was implemented to develop a new Teriparatide Pen for the treatment of osteoporosis. Teriparatide 96-108 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 109-112 34287896-1 2021 In this experiment, we designed an electrochemical sensor using penicillinase (Pen X)-rhombus porous carbon (RPC) as the detection element and hematoxylin as the indicator to detect low concentrations of penicillin sodium (Pen G). Carbon 101-107 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 79-82 34696121-0 2021 Single-Use Fluidic Electrochemical Paper-Based Analytical Devices Fabricated by Pen Plotting and Screen-Printing for On-Site Rapid Voltammetric Monitoring of Pb(II) and Cd(II). cd(ii) 169-175 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 80-83 34610238-3 2021 Here, we use angular-resolved UV/vis absorption spectroscopy to characterize the CTXs of crystalline pentacene:perfluoro-pentacene (PEN:PFP) films allowing determination of the polarization of this state. pentacene 101-110 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 132-135 34610238-3 2021 Here, we use angular-resolved UV/vis absorption spectroscopy to characterize the CTXs of crystalline pentacene:perfluoro-pentacene (PEN:PFP) films allowing determination of the polarization of this state. perfluoro-pentacene 111-130 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 132-135 34379328-2 2021 It is understood that intersections with different intersecting sequences made by the same laser printer and the same gel pen are distinct from each other under coaxial light, and the appearance of an oil film or bright metallic marks in the regions of interest can be used as the basis to identify that the ink is above the toner. Oils 201-204 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 122-125 34504668-4 2021 PEN contains proteomic and phosphoproteomic data on 4,129,728 peptides, 13,862 proteins, 7,138 phosphorylation site-associated genomic variations, 117 studies, and 12 cancer. Peptides 62-70 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 0-3 34287896-1 2021 In this experiment, we designed an electrochemical sensor using penicillinase (Pen X)-rhombus porous carbon (RPC) as the detection element and hematoxylin as the indicator to detect low concentrations of penicillin sodium (Pen G). Hematoxylin 143-154 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 223-226 34287896-1 2021 In this experiment, we designed an electrochemical sensor using penicillinase (Pen X)-rhombus porous carbon (RPC) as the detection element and hematoxylin as the indicator to detect low concentrations of penicillin sodium (Pen G). Penicillin G 204-221 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 79-82 34287896-1 2021 In this experiment, we designed an electrochemical sensor using penicillinase (Pen X)-rhombus porous carbon (RPC) as the detection element and hematoxylin as the indicator to detect low concentrations of penicillin sodium (Pen G). Penicillin G 204-221 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 223-226 35527562-7 2022 RESULTS: Coinjection of proSAAS-encoding lentivirus profoundly reduced the motor asymmetry caused by unilateral nigral AAV-mediated human aSyn overexpression. CHEMBL2031461 119-122 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 24-31 34206028-0 2021 A Surgical Pen-Type Probe Design for Real-Time Optical Diagnosis of Tumor Status Using 5-Aminolevulinic Acid. 5-amino levulinic acid 87-108 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 11-14 34095669-0 2021 Zero-Order Controlled Release of Water-Soluble Drugs Using a Marker Pen Platform. Water 33-38 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 68-71 34095669-3 2021 Inspired by the marker pen, which stores the water-based ink in the sponge core and releases a constant amount of ink from the tip for writing, we explore the marker pen as a drug delivery platform to achieve zero-order release of water-soluble drugs. Water 45-50 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 23-26 34095669-3 2021 Inspired by the marker pen, which stores the water-based ink in the sponge core and releases a constant amount of ink from the tip for writing, we explore the marker pen as a drug delivery platform to achieve zero-order release of water-soluble drugs. Water 45-50 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 166-169 34095669-3 2021 Inspired by the marker pen, which stores the water-based ink in the sponge core and releases a constant amount of ink from the tip for writing, we explore the marker pen as a drug delivery platform to achieve zero-order release of water-soluble drugs. Water 231-236 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 23-26 34095669-3 2021 Inspired by the marker pen, which stores the water-based ink in the sponge core and releases a constant amount of ink from the tip for writing, we explore the marker pen as a drug delivery platform to achieve zero-order release of water-soluble drugs. Water 231-236 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 166-169 34095669-4 2021 Through the capillary interaction between the material and water, the pen core can absorb the aqueous drug solution to encapsulate and store the water-soluble drug model sodium fluorescein (SF) and can release the encapsulated SF by moving the pen tip across the surface. Water 59-64 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 70-73 34095669-4 2021 Through the capillary interaction between the material and water, the pen core can absorb the aqueous drug solution to encapsulate and store the water-soluble drug model sodium fluorescein (SF) and can release the encapsulated SF by moving the pen tip across the surface. Water 59-64 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 244-247 34095669-4 2021 Through the capillary interaction between the material and water, the pen core can absorb the aqueous drug solution to encapsulate and store the water-soluble drug model sodium fluorescein (SF) and can release the encapsulated SF by moving the pen tip across the surface. Water 145-150 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 70-73 34095669-4 2021 Through the capillary interaction between the material and water, the pen core can absorb the aqueous drug solution to encapsulate and store the water-soluble drug model sodium fluorescein (SF) and can release the encapsulated SF by moving the pen tip across the surface. Fluorescein 170-188 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 70-73 34095669-4 2021 Through the capillary interaction between the material and water, the pen core can absorb the aqueous drug solution to encapsulate and store the water-soluble drug model sodium fluorescein (SF) and can release the encapsulated SF by moving the pen tip across the surface. Fluorescein 190-192 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 70-73 35506547-1 2022 Herein, a so-called carbon nanotube (CNT) electrode was printed in on a paper substrate using the handwriting technique and carbon nanotube ink in a marker pen to print the working electrode, graphite pencil to print the counter electrode and graphite/silver nanoparticle (AgNP) ink in a rollerball pen to print the quasi-reference electrode. Carbon 20-26 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 156-159 35506547-1 2022 Herein, a so-called carbon nanotube (CNT) electrode was printed in on a paper substrate using the handwriting technique and carbon nanotube ink in a marker pen to print the working electrode, graphite pencil to print the counter electrode and graphite/silver nanoparticle (AgNP) ink in a rollerball pen to print the quasi-reference electrode. Carbon 20-26 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 299-302 34110664-2 2021 Pyramidal pen arrays, consisting of more than 10 000 hydrogel pens loaded with metal salts, are integrated into a three-electrode cell and used to locally reduce ions at each pen tip. metal salts 79-90 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 10-13 34110664-2 2021 Pyramidal pen arrays, consisting of more than 10 000 hydrogel pens loaded with metal salts, are integrated into a three-electrode cell and used to locally reduce ions at each pen tip. metal salts 79-90 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 175-178 35048423-2 2022 OBJECTIVE: The aim of this study was to compare the safety and pharmacokinetics of inhaled apomorphine (AZ-009) with subcutaneous apomorphine (APO-go PEN) in healthy volunteers (HVs) and to examine the safety, pharmacokinetics, and efficacy of AZ-009 in patients with PD. Apomorphine 130-141 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 150-153 35421906-0 2022 Serotonin Syndrome Misdiagnosed in a Patient Who Used a Cannabis Dab Pen. cannabis dab 56-68 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 69-72 35123070-0 2022 Evaluating Use of the Octreotide Acetate Pen Injector in a Summative Human Factors Validation Study. Octreotide 22-40 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 41-44 35123070-2 2022 We aimed to validate the safe and effective use of the octreotide acetate pen injector, its labelling, and instructions for use (IFU) by patients, caregivers, and HCPs and mitigation of use-related risks. Octreotide 55-73 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 74-77 35123070-16 2022 CONCLUSION: The octreotide acetate pen injector, labelling, and IFU enabled intended users to administer subcutaneous octreotide safely and effectively. Octreotide 16-34 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 35-38 35123070-16 2022 CONCLUSION: The octreotide acetate pen injector, labelling, and IFU enabled intended users to administer subcutaneous octreotide safely and effectively. Octreotide 118-128 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 35-38 35406227-2 2022 We studied the formation of thermoresponsive hydrogels with beta-glycerol phosphate and found proper formulations that form the hydrogels at 37 C. Gel formation depended on the chitosan source being possible to produce the thermoresponsive hydrogels at chitosan concentration of 1% with cuttlebone chitosan but 1.5% was needed for squid pen. Chitosan 178-186 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 338-341 35119205-2 2022 With precise spatiotemporal control over the illumination pattern, beam pen lithography (BPL) allows for the photo-crosslinking of polymers into ultrahigh resolution features over centimeter-scale areas using massively parallel >160 000 pen arrays of individually addressable pens that guide and focus light onto the surface with sub-diffraction resolution. Polymers 131-139 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 72-75 35119205-2 2022 With precise spatiotemporal control over the illumination pattern, beam pen lithography (BPL) allows for the photo-crosslinking of polymers into ultrahigh resolution features over centimeter-scale areas using massively parallel >160 000 pen arrays of individually addressable pens that guide and focus light onto the surface with sub-diffraction resolution. Polymers 131-139 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 237-240 35191669-1 2022 d-Penicillamine (d-Pen) is a sulfur compound used in the management of rheumatoid arthritis, Wilson"s disease (WD), and alcohol dependence. Penicillamine 0-15 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 19-22 35191669-1 2022 d-Penicillamine (d-Pen) is a sulfur compound used in the management of rheumatoid arthritis, Wilson"s disease (WD), and alcohol dependence. Sulfur 29-35 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 19-22 35191669-4 2022 Based on the well-known oxidase activity of hemoproteins and the participation of catalase in cellular H2O2 redox signaling, we posit that d-Pen could inactivate catalase, thus disturbing H2O2 levels. Hydrogen Peroxide 103-107 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 141-144 35191669-4 2022 Based on the well-known oxidase activity of hemoproteins and the participation of catalase in cellular H2O2 redox signaling, we posit that d-Pen could inactivate catalase, thus disturbing H2O2 levels. Hydrogen Peroxide 188-192 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 141-144 35191669-6 2022 Initially, d-Pen reacts with native catalase and/or iron metal ions, used to mimic non-heme iron overload observed in long-term treated WD patients, to generate thiyl radicals. Iron 52-62 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 13-16 35191669-6 2022 Initially, d-Pen reacts with native catalase and/or iron metal ions, used to mimic non-heme iron overload observed in long-term treated WD patients, to generate thiyl radicals. Heme 87-91 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 13-16 35191669-6 2022 Initially, d-Pen reacts with native catalase and/or iron metal ions, used to mimic non-heme iron overload observed in long-term treated WD patients, to generate thiyl radicals. Iron 92-96 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 13-16 35191669-6 2022 Initially, d-Pen reacts with native catalase and/or iron metal ions, used to mimic non-heme iron overload observed in long-term treated WD patients, to generate thiyl radicals. thiyl radicals 161-175 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 13-16 35191669-9 2022 These findings support the evidence that d-Pen could perturb H2O2 redox homeostasis through transient but recurring catalase inactivation, which may in part rationalize some deleterious effects observed with this therapeutic agent, as discussed. Hydrogen Peroxide 61-65 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 43-46 35175046-2 2022 A thermoprocessable carbon black-loaded, electronically conducting, polylactide polymer composite was used to prepare substrate electrodes of user"s defined shape/arrangement applying a 3D pen in a hot melt process. Polymers 80-87 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 189-192 35225603-0 2022 Chemo-Selective Cys-Pen Disulfide for Proximity-Induced Cysteine Cross-Linking. Cysteine 56-64 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 20-23 35225603-4 2022 Cysteine-cysteine (Cys-Cys) disulfide bonds are intrinsically unstable in endogenous reductive environment, while cysteine-penicillamine (Cys-Pen) disulfide bonds show satisfactory stability. cysteine-penicillamine 114-136 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 142-145 35225603-4 2022 Cysteine-cysteine (Cys-Cys) disulfide bonds are intrinsically unstable in endogenous reductive environment, while cysteine-penicillamine (Cys-Pen) disulfide bonds show satisfactory stability. Disulfides 147-156 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 142-145 35225603-5 2022 We envisioned the Cys-Pen disulfide as a potential ligand-induced covalent bonding warhead, and this disulfide could reconstruct with the protein cysteine in the vicinity of the peptide binding site to form a new disulfide. Disulfides 101-110 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 22-25 35225603-5 2022 We envisioned the Cys-Pen disulfide as a potential ligand-induced covalent bonding warhead, and this disulfide could reconstruct with the protein cysteine in the vicinity of the peptide binding site to form a new disulfide. Cysteine 146-154 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 22-25 35225603-5 2022 We envisioned the Cys-Pen disulfide as a potential ligand-induced covalent bonding warhead, and this disulfide could reconstruct with the protein cysteine in the vicinity of the peptide binding site to form a new disulfide. Disulfides 213-222 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 22-25 35225603-7 2022 Both proteins were successfully modified by Cys-Pen disulfide and formed new disulfides between proteins and peptides. Disulfides 77-87 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 48-51 35225603-8 2022 The new disulfide was then analyzed to confirm it was a newly formed disulfide bond between Pen of the ligand and a protein Cys near the ligand binding site. Disulfides 8-17 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 92-95 35225603-8 2022 The new disulfide was then analyzed to confirm it was a newly formed disulfide bond between Pen of the ligand and a protein Cys near the ligand binding site. Disulfides 69-78 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 92-95 35225603-8 2022 The new disulfide was then analyzed to confirm it was a newly formed disulfide bond between Pen of the ligand and a protein Cys near the ligand binding site. Cysteine 124-127 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 92-95 35014649-2 2022 ),1 the magnetomechanical behavior of cobalt (Co) magnetic nanowire arrays on a polymeric substrate (polyethylene naphthalate (PEN)) under bending was measured by magneto-optical Kerr effect (MOKE) magnetometry in situ. Cobalt 38-49 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 101-132 34953135-5 2022 Also, Kiss1 ARH neurons co-express glutamate and Kiss1 AVPV/PeN neurons co-express GABA, both of which are upregulated by E2 in females. gamma-Aminobutyric Acid 83-87 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 60-63 34953135-5 2022 Also, Kiss1 ARH neurons co-express glutamate and Kiss1 AVPV/PeN neurons co-express GABA, both of which are upregulated by E2 in females. Estradiol 122-124 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 60-63 34953135-8 2022 Kiss1 ARH and Kiss1 AVPV/PeN neurons also project to the pre-autonomic paraventricular nucleus (satiety) neurons and the dorsomedial nucleus (energy expenditure) neurons to differentially regulate their function via glutamate and GABA release, respectively. Glutamic Acid 216-225 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 25-28 34953135-8 2022 Kiss1 ARH and Kiss1 AVPV/PeN neurons also project to the pre-autonomic paraventricular nucleus (satiety) neurons and the dorsomedial nucleus (energy expenditure) neurons to differentially regulate their function via glutamate and GABA release, respectively. gamma-Aminobutyric Acid 230-234 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 25-28 34953135-3 2022 There are two distinct populations of hypothalamic Kiss1 neurons, namely arcuate nucleus (Kiss1 ARH) neurons and anteroventral periventricular and periventricular nucleus (Kiss1 AVPV/PeN) neurons in rodents, both of which excite GnRH neurons via kisspeptin release but are differentially regulated by ovarian steroids. Steroids 309-317 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 183-186 34953135-4 2022 Estradiol (E2) increases the expression of kisspeptin in Kiss1 AVPV/PeN neurons but decreases its expression in Kiss1 ARH neurons. Estradiol 0-9 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 68-71 34953135-4 2022 Estradiol (E2) increases the expression of kisspeptin in Kiss1 AVPV/PeN neurons but decreases its expression in Kiss1 ARH neurons. Estradiol 11-13 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 68-71 34980816-1 2022 Follitropin Delta (Rekovellle Subcutaneous Injection 12 mug/ 36 mug/72 mug Pen) is a recombinant human follicle-stimulating hormone (rFSH) developed by Ferring Pharmaceuticals Co., Ltd. Because human follicle-stimulating hormone (FSH) gene is incorporated into a human-derived cell line (human embryonic retinoblastoma: PER.C6), the Follitropin Delta is produced with having alpha2.3 and alpha2.6 linked sialic acid sugar chain which is similar to natural human FSH. N-Acetylneuraminic Acid 404-415 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 75-78 35381093-2 2022 Chromogranin A (CgA) and peptide proSAAS belong to the family of granins and are present in neuroendocrine cells of adrenal medulla, from where they are released to circulation, along with catecholamines. Catecholamines 189-203 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 33-40 34980816-1 2022 Follitropin Delta (Rekovellle Subcutaneous Injection 12 mug/ 36 mug/72 mug Pen) is a recombinant human follicle-stimulating hormone (rFSH) developed by Ferring Pharmaceuticals Co., Ltd. Because human follicle-stimulating hormone (FSH) gene is incorporated into a human-derived cell line (human embryonic retinoblastoma: PER.C6), the Follitropin Delta is produced with having alpha2.3 and alpha2.6 linked sialic acid sugar chain which is similar to natural human FSH. Sugars 416-421 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 75-78 35222920-4 2022 Such reducible solubilizing tags (RSTs) are compatible with peptide salicylaldehyde ester-mediated Ser/Thr ligation and Cys/Pen ligation for purifying and ligating peptides with poor solubility. Cysteine 120-123 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 124-127 35222920-4 2022 Such reducible solubilizing tags (RSTs) are compatible with peptide salicylaldehyde ester-mediated Ser/Thr ligation and Cys/Pen ligation for purifying and ligating peptides with poor solubility. Peptides 164-172 proprotein convertase subtilisin/kexin type 1 inhibitor Homo sapiens 124-127