PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
35581939-8	2022	These findings provide novel insight into CDK12 being necessary for maintaining renal homeostasis by regulating NKCC2 transcription, which explains the critical water and electrolyte disturbance that occurs during the application of CDK12 inhibitors for cancer treatment.	Water	161-166	cyclin-dependent kinase 12	Mus musculus	42-47
17638870-10	2007	Mammary tissues of Cdc25A(+/-);MMTV-neu mice before tumor development display less proliferative response to the oncogene with increased tyrosine phosphorylation of CDK1/2, but show no significant change in apoptosis.	Tyrosine	137-145	cyclin-dependent kinase 12	Mus musculus	165-171
35581939-8	2022	These findings provide novel insight into CDK12 being necessary for maintaining renal homeostasis by regulating NKCC2 transcription, which explains the critical water and electrolyte disturbance that occurs during the application of CDK12 inhibitors for cancer treatment.	Water	161-166	cyclin-dependent kinase 12	Mus musculus	233-238
35550508-3	2022	Integrative transcriptomic, metabolomic and functional data reveal that hyperactivation of the serine-glycine-one-carbon network is a metabolic hallmark inherent to CDK12-induced tumorigenesis.	Serine	95-101	cyclin-dependent kinase 12	Mus musculus	165-170
35550508-3	2022	Integrative transcriptomic, metabolomic and functional data reveal that hyperactivation of the serine-glycine-one-carbon network is a metabolic hallmark inherent to CDK12-induced tumorigenesis.	Glycine	102-109	cyclin-dependent kinase 12	Mus musculus	165-170
35550508-3	2022	Integrative transcriptomic, metabolomic and functional data reveal that hyperactivation of the serine-glycine-one-carbon network is a metabolic hallmark inherent to CDK12-induced tumorigenesis.	Carbon	114-120	cyclin-dependent kinase 12	Mus musculus	165-170
32941949-2	2020	In the present study, we reported a synergistic and durable immune-mediated antitumor response elicited by the combined treatment of SR-4835, a CDK12/13 specific inhibitor, with PD-1 blockade in a syngeneic mouse model.	SR-4835	133-140	cyclin-dependent kinase 12	Mus musculus	144-152
33381022-15	2020	In addition, miR-433 upregulated the expression of Cdk12 and inhibited cell proliferation in a Cdk12-dependent manner and promoted apoptosis in HT-22 cells under the treatment of 10-hydroxycamptothecin.	10-hydroxycamptothecin	179-201	cyclin-dependent kinase 12	Mus musculus	51-56
27358111-11	2016	IMPLICATIONS: Augmented HR repair is a novel mechanism underlying acquired temozolomide resistance in GBM, and this raises the possibility of improving the therapeutic response to temozolomide by targeting HR with small-molecule inhibitors of CDK1/2.	Temozolomide	75-87	cyclin-dependent kinase 12	Mus musculus	243-249
27358111-11	2016	IMPLICATIONS: Augmented HR repair is a novel mechanism underlying acquired temozolomide resistance in GBM, and this raises the possibility of improving the therapeutic response to temozolomide by targeting HR with small-molecule inhibitors of CDK1/2.	Temozolomide	180-192	cyclin-dependent kinase 12	Mus musculus	243-249