PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
33200195-1	2020	The Tiam family proteins - Tiam1 and Tiam2/STEF - are Rac1-specific Guanine Nucleotide Exchange Factors (GEFs) with important functions in epithelial, neuronal, immune and other cell types.	Guanine Nucleotides	68-86	TIAM Rac1 associated GEF 2	Homo sapiens	37-42
33284659-1	2021	BACKGROUND AND AIM: As a Rac1 guanine nucleotide exchange factor, T-cell lymphoma invasion and metastasis 2 (TIAM2) has been reported to be correlated with malignant phenotypes in several cancers, but its prognostic significance and function in pancreatic ductal adenocarcinoma (PDAC) was not investigated.	Guanine Nucleotides	30-48	TIAM Rac1 associated GEF 2	Homo sapiens	66-107
33284659-1	2021	BACKGROUND AND AIM: As a Rac1 guanine nucleotide exchange factor, T-cell lymphoma invasion and metastasis 2 (TIAM2) has been reported to be correlated with malignant phenotypes in several cancers, but its prognostic significance and function in pancreatic ductal adenocarcinoma (PDAC) was not investigated.	Guanine Nucleotides	30-48	TIAM Rac1 associated GEF 2	Homo sapiens	109-114
33200195-1	2020	The Tiam family proteins - Tiam1 and Tiam2/STEF - are Rac1-specific Guanine Nucleotide Exchange Factors (GEFs) with important functions in epithelial, neuronal, immune and other cell types.	Guanine Nucleotides	68-86	TIAM Rac1 associated GEF 2	Homo sapiens	43-47
31908036-1	2020	TIAM2S, the short form of human T-cell lymphoma invasion and metastasis 2, can have oncogenic effects when aberrantly expressed in the liver or lungs.	tiam2s	0-6	TIAM Rac1 associated GEF 2	Homo sapiens	32-73
29844364-3	2018	Here, we demonstrate that STEF/TIAM2, a Rac1 selective guanine nucleotide exchange factor, localises at the nuclear envelope, co-localising with the key perinuclear proteins Nesprin-2G and Non-muscle myosin IIB (NMMIIB), where it regulates perinuclear Rac1 activity.	Guanine Nucleotides	55-73	TIAM Rac1 associated GEF 2	Homo sapiens	26-30
29844364-3	2018	Here, we demonstrate that STEF/TIAM2, a Rac1 selective guanine nucleotide exchange factor, localises at the nuclear envelope, co-localising with the key perinuclear proteins Nesprin-2G and Non-muscle myosin IIB (NMMIIB), where it regulates perinuclear Rac1 activity.	Guanine Nucleotides	55-73	TIAM Rac1 associated GEF 2	Homo sapiens	31-36
27597758-5	2016	Systematic depletion of Rho family GTPases and their regulatory proteins identified the Rac subfamily and the Rac-specific guanine nucleotide exchange factor Tiam2 as key components of EphB2 trans-endocytosis, a pathway previously implicated in Eph forward signaling, in which ephrins act as in trans ligands of Eph receptors.	Guanine Nucleotides	123-141	TIAM Rac1 associated GEF 2	Homo sapiens	158-163
19893486-1	2010	Tiam1 and Tiam2 (Tiam1/2) are guanine nucleotide-exchange factors that possess the PH-CC-Ex (pleckstrin homology, coiled coil and extra) region that mediates binding to plasma membranes and signalling proteins in the activation of Rac GTPases.	Guanine Nucleotides	30-48	TIAM Rac1 associated GEF 2	Homo sapiens	10-15
19893486-1	2010	Tiam1 and Tiam2 (Tiam1/2) are guanine nucleotide-exchange factors that possess the PH-CC-Ex (pleckstrin homology, coiled coil and extra) region that mediates binding to plasma membranes and signalling proteins in the activation of Rac GTPases.	Guanine Nucleotides	30-48	TIAM Rac1 associated GEF 2	Homo sapiens	17-24
18997336-0	2008	Crystallographic characterization of the membrane-targeting domains of the Rac-specific guanine nucleotide-exchange factors Tiam1 and Tiam2.	Guanine Nucleotides	88-106	TIAM Rac1 associated GEF 2	Homo sapiens	134-139
18997336-1	2008	T-lymphoma invasion and metastasis 1 and 2 (Tiam1 and Tiam2) are guanine nucleotide-exchange factors that specifically activate Rac GTPase by facilitating the dissociation of GDP.	Guanine Nucleotides	65-83	TIAM Rac1 associated GEF 2	Homo sapiens	54-59
18997336-1	2008	T-lymphoma invasion and metastasis 1 and 2 (Tiam1 and Tiam2) are guanine nucleotide-exchange factors that specifically activate Rac GTPase by facilitating the dissociation of GDP.	Guanosine Diphosphate	175-178	TIAM Rac1 associated GEF 2	Homo sapiens	54-59
20224579-5	2010	As a result, FAs in STEF-knockdown cells have a reduced disassembly rate and are consequently enlarged.	ammonium ferrous sulfate	13-16	TIAM Rac1 associated GEF 2	Homo sapiens	20-24
18267089-2	2008	PAR-3 directly interacts with Tiam1/Taim2 (STEF), Rac1-specific guanine nucleotide exchange factors, and forms a complex with aPKC-PAR-6-Cdc42*GTP, leading to Rac1 activation.	Guanosine Triphosphate	143-146	TIAM Rac1 associated GEF 2	Homo sapiens	43-47