PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
28713569-2	2017	Potassium channel tetramerization domain-containing protein (KCTD) 12 is a GABABR auxiliary subunit and mouse KCTD12 can alter GABABR function.	gababr	127-133	potassium channel tetramerisation domain containing 12	Mus musculus	110-116
28713569-7	2017	KCTD12 coexpression enhanced the potentiating effects of the positive allosteric modulator CGP7930, and its effects on GABABR activation and desensitization.	gababr	119-125	potassium channel tetramerisation domain containing 12	Mus musculus	0-6
28713569-10	2017	In the two bottle preference test, KCTD12 knockout mice demonstrated a reduced consumption at high ethanol concentrations.	Ethanol	99-106	potassium channel tetramerisation domain containing 12	Mus musculus	35-41
28713569-12	2017	This study also provides novel in vivo evidence that the interaction between KCTD12 and GABABR is of physiological significance, and may be a mechanism to more selectively modulate GABABR.	gababr	88-94	potassium channel tetramerisation domain containing 12	Mus musculus	77-83
28713569-12	2017	This study also provides novel in vivo evidence that the interaction between KCTD12 and GABABR is of physiological significance, and may be a mechanism to more selectively modulate GABABR.	gababr	181-187	potassium channel tetramerisation domain containing 12	Mus musculus	77-83
27073217-8	2017	In response to prolonged activation, GABABR-mediated currents displayed strong desensitization, which was absent in KCTD12-deficient mice.	gababr	37-43	potassium channel tetramerisation domain containing 12	Mus musculus	116-122
25065880-10	2014	Serine-892 phosphorylation in heterologous cells rearranges KCTD12 at the receptor and slows KCTD12-induced desensitization.	Serine	0-6	potassium channel tetramerisation domain containing 12	Mus musculus	60-66
25065880-10	2014	Serine-892 phosphorylation in heterologous cells rearranges KCTD12 at the receptor and slows KCTD12-induced desensitization.	Serine	0-6	potassium channel tetramerisation domain containing 12	Mus musculus	93-99
25065880-13	2014	Fast current desensitization is accelerated in hippocampal neurons carrying the serine-892 to alanine mutation, showing that tonic serine-892 phosphorylation normally limits KCTD12-induced desensitization.	Serine	80-86	potassium channel tetramerisation domain containing 12	Mus musculus	174-180
25065880-14	2014	Tonic serine-892 phosphorylation is in turn promoted by assembly of receptors with KCTD12.	Serine	6-12	potassium channel tetramerisation domain containing 12	Mus musculus	83-89
25065880-15	2014	This cross-regulation of serine-892 phosphorylation and KCTD12 activity sharpens the response during repeated receptor activation.	Serine	25-31	potassium channel tetramerisation domain containing 12	Mus musculus	56-62
33285230-7	2021	Furthermore, an increased expression of GABAB receptor 2 (GB2) in the DG of CSDS-treated mice was observed, and CGP35348, an antagonist of GABABR, improved the stress-induced behavior responses along with suppressing the excess expression of Kctd12.	CGP 35348	112-120	potassium channel tetramerisation domain containing 12	Mus musculus	242-248
33285230-8	2021	In addition, Kctd12 regulated the excitability of granule cell in DG, and the stimulation of neuronal activity by silencing Kctd12 contributed to the antidepressant-like effect of fluoxetine.	Fluoxetine	180-190	potassium channel tetramerisation domain containing 12	Mus musculus	13-19
33285230-8	2021	In addition, Kctd12 regulated the excitability of granule cell in DG, and the stimulation of neuronal activity by silencing Kctd12 contributed to the antidepressant-like effect of fluoxetine.	Fluoxetine	180-190	potassium channel tetramerisation domain containing 12	Mus musculus	124-130
31565480-2	2019	In a previous study, we found that levels of BTB/POZ domain-containing protein KCTD12 are lower in metastatic melanoma cells than in parental melanoma cells.	BTB-1 compound	45-48	potassium channel tetramerisation domain containing 12	Mus musculus	79-85