PMID-sentid	Pub_year	Sent_text	comp_official_name	comp_offset	protein_name	organism	prot_offset
2556389-3	1989	When air-saturated borate buffer (pH 9.0) containing linoleic acid or arachidonate acid was mixed with lipoxygenase, fatty acid-derived peroxyl free radicals were readily detected; these radicals have a characteristic g-value of 2.014.	fatty acid-derived peroxyl free radicals	117-157	linoleate 9S-lipoxygenase-4	Glycine max	103-115
2556389-0	1989	Lipid peroxyl radical intermediates in the peroxidation of polyunsaturated fatty acids by lipoxygenase.	perhydroxyl radical	6-21	linoleate 9S-lipoxygenase-4	Glycine max	90-102
2556389-8	1989	Arachidonate peroxyl radical formation was shown to be dependent on the substrate, active lipoxygenase, and molecular oxygen.	arachidonate peroxyl radical	0-28	linoleate 9S-lipoxygenase-4	Glycine max	90-102
2556389-0	1989	Lipid peroxyl radical intermediates in the peroxidation of polyunsaturated fatty acids by lipoxygenase.	Fatty Acids, Unsaturated	59-86	linoleate 9S-lipoxygenase-4	Glycine max	90-102
2556389-2	1989	Lipid peroxyl radicals resulting from the peroxidation of polyunsaturated fatty acids by soybean lipoxygenase were directly detected by the method of rapid mixing, continuous-flow electron spin resonance spectroscopy.	perhydroxyl radical	6-22	linoleate 9S-lipoxygenase-4	Glycine max	97-109
2513351-1	1989	Activity of trout gill and soybean lipoxygenase was inhibited by various low concentrations of tri-n-butyltin, di-n-butyltin and n-butyltin chlorides at pH 7.8.	tributyltin	95-109	linoleate 9S-lipoxygenase-4	Glycine max	35-47
2556389-2	1989	Lipid peroxyl radicals resulting from the peroxidation of polyunsaturated fatty acids by soybean lipoxygenase were directly detected by the method of rapid mixing, continuous-flow electron spin resonance spectroscopy.	Fatty Acids, Unsaturated	58-85	linoleate 9S-lipoxygenase-4	Glycine max	97-109
2556389-3	1989	When air-saturated borate buffer (pH 9.0) containing linoleic acid or arachidonate acid was mixed with lipoxygenase, fatty acid-derived peroxyl free radicals were readily detected; these radicals have a characteristic g-value of 2.014.	air-saturated borate	5-25	linoleate 9S-lipoxygenase-4	Glycine max	103-115
2513351-4	1989	Although tri-n-butyltin (0.067-0.2 mM; 13-68% inhibition) was less inhibitory to soybean lipoxygenase, di-n-butyltin (0.134-0.537 mM; 51-75% inhibition) and n-butyltin (0.41-1.23 mM; 33-75% inhibition) were more inhibitory towards soybean lipoxygenase compared with trout gill lipoxygenase.	tributyltin	9-23	linoleate 9S-lipoxygenase-4	Glycine max	89-101
2557901-2	1989	Recent studies showed that soybean lipoxygenase inhibitors like phenidone and nordihydroguaiaretic acid (NDGA) reduce the catalytically active ferric lipoxygenase to its inactive ferrous form.	phenidone	64-73	linoleate 9S-lipoxygenase-4	Glycine max	35-47
2557901-2	1989	Recent studies showed that soybean lipoxygenase inhibitors like phenidone and nordihydroguaiaretic acid (NDGA) reduce the catalytically active ferric lipoxygenase to its inactive ferrous form.	phenidone	64-73	linoleate 9S-lipoxygenase-4	Glycine max	150-162
2557901-2	1989	Recent studies showed that soybean lipoxygenase inhibitors like phenidone and nordihydroguaiaretic acid (NDGA) reduce the catalytically active ferric lipoxygenase to its inactive ferrous form.	Masoprocol	78-103	linoleate 9S-lipoxygenase-4	Glycine max	35-47
2557901-2	1989	Recent studies showed that soybean lipoxygenase inhibitors like phenidone and nordihydroguaiaretic acid (NDGA) reduce the catalytically active ferric lipoxygenase to its inactive ferrous form.	Masoprocol	78-103	linoleate 9S-lipoxygenase-4	Glycine max	150-162
2557901-2	1989	Recent studies showed that soybean lipoxygenase inhibitors like phenidone and nordihydroguaiaretic acid (NDGA) reduce the catalytically active ferric lipoxygenase to its inactive ferrous form.	Masoprocol	105-109	linoleate 9S-lipoxygenase-4	Glycine max	35-47
2557901-2	1989	Recent studies showed that soybean lipoxygenase inhibitors like phenidone and nordihydroguaiaretic acid (NDGA) reduce the catalytically active ferric lipoxygenase to its inactive ferrous form.	Masoprocol	105-109	linoleate 9S-lipoxygenase-4	Glycine max	150-162
2557901-5	1989	Incubation of soybean lipoxygenase and linoleic acid with p-aminophenol, catechol, hydroquinone, NDGA, or phenidone resulted in the formation of the one-electron oxidation products of these compounds.	4-aminophenol	58-71	linoleate 9S-lipoxygenase-4	Glycine max	22-34
2557901-5	1989	Incubation of soybean lipoxygenase and linoleic acid with p-aminophenol, catechol, hydroquinone, NDGA, or phenidone resulted in the formation of the one-electron oxidation products of these compounds.	catechol	73-81	linoleate 9S-lipoxygenase-4	Glycine max	22-34
2557901-5	1989	Incubation of soybean lipoxygenase and linoleic acid with p-aminophenol, catechol, hydroquinone, NDGA, or phenidone resulted in the formation of the one-electron oxidation products of these compounds.	hydroquinone	83-95	linoleate 9S-lipoxygenase-4	Glycine max	22-34
2557901-5	1989	Incubation of soybean lipoxygenase and linoleic acid with p-aminophenol, catechol, hydroquinone, NDGA, or phenidone resulted in the formation of the one-electron oxidation products of these compounds.	Masoprocol	97-101	linoleate 9S-lipoxygenase-4	Glycine max	22-34
2557901-5	1989	Incubation of soybean lipoxygenase and linoleic acid with p-aminophenol, catechol, hydroquinone, NDGA, or phenidone resulted in the formation of the one-electron oxidation products of these compounds.	phenidone	106-115	linoleate 9S-lipoxygenase-4	Glycine max	22-34
2557901-6	1989	Free-radical formation depended upon the presence of the lipoxygenase and 13-HPOD.	Free Radicals	0-12	linoleate 9S-lipoxygenase-4	Glycine max	57-69
2514267-8	1989	Nordihydroguaiaretic acid (NDGA), the most potent lipoxygenase inhibitor, was a competitive inhibitor with Ki = 0.29 microM.	Masoprocol	0-25	linoleate 9S-lipoxygenase-4	Glycine max	50-62
2514267-8	1989	Nordihydroguaiaretic acid (NDGA), the most potent lipoxygenase inhibitor, was a competitive inhibitor with Ki = 0.29 microM.	Masoprocol	27-31	linoleate 9S-lipoxygenase-4	Glycine max	50-62
2513351-4	1989	Although tri-n-butyltin (0.067-0.2 mM; 13-68% inhibition) was less inhibitory to soybean lipoxygenase, di-n-butyltin (0.134-0.537 mM; 51-75% inhibition) and n-butyltin (0.41-1.23 mM; 33-75% inhibition) were more inhibitory towards soybean lipoxygenase compared with trout gill lipoxygenase.	tributyltin	9-23	linoleate 9S-lipoxygenase-4	Glycine max	239-251
2513351-1	1989	Activity of trout gill and soybean lipoxygenase was inhibited by various low concentrations of tri-n-butyltin, di-n-butyltin and n-butyltin chlorides at pH 7.8.	di-n-butyltin	111-124	linoleate 9S-lipoxygenase-4	Glycine max	35-47
2513351-4	1989	Although tri-n-butyltin (0.067-0.2 mM; 13-68% inhibition) was less inhibitory to soybean lipoxygenase, di-n-butyltin (0.134-0.537 mM; 51-75% inhibition) and n-butyltin (0.41-1.23 mM; 33-75% inhibition) were more inhibitory towards soybean lipoxygenase compared with trout gill lipoxygenase.	tributyltin	9-23	linoleate 9S-lipoxygenase-4	Glycine max	239-251
2513351-1	1989	Activity of trout gill and soybean lipoxygenase was inhibited by various low concentrations of tri-n-butyltin, di-n-butyltin and n-butyltin chlorides at pH 7.8.	n-butyltin chlorides	129-149	linoleate 9S-lipoxygenase-4	Glycine max	35-47
2513351-4	1989	Although tri-n-butyltin (0.067-0.2 mM; 13-68% inhibition) was less inhibitory to soybean lipoxygenase, di-n-butyltin (0.134-0.537 mM; 51-75% inhibition) and n-butyltin (0.41-1.23 mM; 33-75% inhibition) were more inhibitory towards soybean lipoxygenase compared with trout gill lipoxygenase.	n-butyltin	13-23	linoleate 9S-lipoxygenase-4	Glycine max	89-101
2513351-4	1989	Although tri-n-butyltin (0.067-0.2 mM; 13-68% inhibition) was less inhibitory to soybean lipoxygenase, di-n-butyltin (0.134-0.537 mM; 51-75% inhibition) and n-butyltin (0.41-1.23 mM; 33-75% inhibition) were more inhibitory towards soybean lipoxygenase compared with trout gill lipoxygenase.	n-butyltin	13-23	linoleate 9S-lipoxygenase-4	Glycine max	239-251
2513351-4	1989	Although tri-n-butyltin (0.067-0.2 mM; 13-68% inhibition) was less inhibitory to soybean lipoxygenase, di-n-butyltin (0.134-0.537 mM; 51-75% inhibition) and n-butyltin (0.41-1.23 mM; 33-75% inhibition) were more inhibitory towards soybean lipoxygenase compared with trout gill lipoxygenase.	n-butyltin	13-23	linoleate 9S-lipoxygenase-4	Glycine max	239-251
2513351-5	1989	Concentrations of butyltins required to provide substantial inhibition of trout gill lipoxygenase were of the order of magnitude of those reported for lethal water exposure concentrations of these compounds for trout and other fishes when bioaccumulation factors are considered.	butyltins	18-27	linoleate 9S-lipoxygenase-4	Glycine max	85-97
2513351-2	1989	Tri-n-butyltin (0.044-0.19 mM; 8-100% inhibition) was significantly more inhibitory against trout gill lipoxygenase than di-n-butyltin (0.1-0.27 mM; 17-39% inhibition) or n-butyltin (1.2-3.6 mM; 26-43% inhibition).	tributyltin	0-14	linoleate 9S-lipoxygenase-4	Glycine max	103-115
2513351-2	1989	Tri-n-butyltin (0.044-0.19 mM; 8-100% inhibition) was significantly more inhibitory against trout gill lipoxygenase than di-n-butyltin (0.1-0.27 mM; 17-39% inhibition) or n-butyltin (1.2-3.6 mM; 26-43% inhibition).	n-butyltin	4-14	linoleate 9S-lipoxygenase-4	Glycine max	103-115
2518221-2	1989	Sulfonic derivatives of quercetin were much weaker inhibitors of soybean lipoxygenase than quercetin itself.	sulfonic	0-8	linoleate 9S-lipoxygenase-4	Glycine max	73-85
2518221-2	1989	Sulfonic derivatives of quercetin were much weaker inhibitors of soybean lipoxygenase than quercetin itself.	Quercetin	24-33	linoleate 9S-lipoxygenase-4	Glycine max	73-85
2474334-1	1989	The rate of linoleic acid peroxidation catalysed by soybean lipoxygenase I was studied as a function of the hydration degree of aerosol OT (bis(2-ethylhexyl) sulfosuccinate sodium salt) reversed micelles in octane.	Linoleic Acid	12-25	linoleate 9S-lipoxygenase-4	Glycine max	60-72
2569867-0	1989	The possible role of 9(S)-hydroperoxyoctadecatrienoic acid as a suicide substrate of soybean lipoxygenase.	9(s)-hydroperoxyoctadecatrienoic acid	21-58	linoleate 9S-lipoxygenase-4	Glycine max	93-105
2569867-1	1989	While incubation of soybean lipoxygenase with alpha-linolenic acid resulted in the gradual decrease of lipoxygenase activity, the incubation with linoleic acid had no change.	alpha-Linolenic Acid	46-66	linoleate 9S-lipoxygenase-4	Glycine max	28-40
2569867-1	1989	While incubation of soybean lipoxygenase with alpha-linolenic acid resulted in the gradual decrease of lipoxygenase activity, the incubation with linoleic acid had no change.	alpha-Linolenic Acid	46-66	linoleate 9S-lipoxygenase-4	Glycine max	103-115
2569867-2	1989	The inactivation of soybean lipoxygenase during incubation with alpha-linolenic acid was markedly observed at pH 6.5, but not at pH 9.0.	alpha-Linolenic Acid	64-84	linoleate 9S-lipoxygenase-4	Glycine max	28-40
2569867-3	1989	Among the lipoxygenation products of alpha-linolenic acid, only 9(S)-hydroperoxyoctadecatrienoic acid caused the inactivation of lipoxygenase.	alpha-Linolenic Acid	37-57	linoleate 9S-lipoxygenase-4	Glycine max	129-141
2569867-3	1989	Among the lipoxygenation products of alpha-linolenic acid, only 9(S)-hydroperoxyoctadecatrienoic acid caused the inactivation of lipoxygenase.	(s)-hydroperoxyoctadecatrienoic acid	65-101	linoleate 9S-lipoxygenase-4	Glycine max	129-141
2569867-5	1989	Accordingly, it is suggested that the epoxide intermediate, one conversion product of 9(S)-hydroperoxyoctadecatrienoic acid, might be involved in the direct inactivation of lipoxygenase.	Epoxy Compounds	38-45	linoleate 9S-lipoxygenase-4	Glycine max	173-185
2569867-5	1989	Accordingly, it is suggested that the epoxide intermediate, one conversion product of 9(S)-hydroperoxyoctadecatrienoic acid, might be involved in the direct inactivation of lipoxygenase.	9(s)-hydroperoxyoctadecatrienoic acid	86-123	linoleate 9S-lipoxygenase-4	Glycine max	173-185
2502778-0	1989	The peroxidase/oxidase activity of soybean lipoxygenase--I. Triplet excited carbonyls from the reaction with isobutanal and the effect of glutathione.	isobutyraldehyde	109-119	linoleate 9S-lipoxygenase-4	Glycine max	43-55
2502778-0	1989	The peroxidase/oxidase activity of soybean lipoxygenase--I. Triplet excited carbonyls from the reaction with isobutanal and the effect of glutathione.	Glutathione	138-149	linoleate 9S-lipoxygenase-4	Glycine max	43-55
2502778-1	1989	Soybean lipoxygenase shows a secondary peroxidase/oxidase activity: The aerobic reaction with isobutanal, enhanced by hydrogen peroxide as a cosubstrate, yields acetone, exhibits chemiluminescence and consumes oxygen (phi cl = 1.3 x 10(-9) photons/O2 molecule consumed).	isobutyraldehyde	94-104	linoleate 9S-lipoxygenase-4	Glycine max	8-20
2502778-1	1989	Soybean lipoxygenase shows a secondary peroxidase/oxidase activity: The aerobic reaction with isobutanal, enhanced by hydrogen peroxide as a cosubstrate, yields acetone, exhibits chemiluminescence and consumes oxygen (phi cl = 1.3 x 10(-9) photons/O2 molecule consumed).	Hydrogen Peroxide	118-135	linoleate 9S-lipoxygenase-4	Glycine max	8-20
2502778-1	1989	Soybean lipoxygenase shows a secondary peroxidase/oxidase activity: The aerobic reaction with isobutanal, enhanced by hydrogen peroxide as a cosubstrate, yields acetone, exhibits chemiluminescence and consumes oxygen (phi cl = 1.3 x 10(-9) photons/O2 molecule consumed).	Acetone	161-168	linoleate 9S-lipoxygenase-4	Glycine max	8-20
2502778-1	1989	Soybean lipoxygenase shows a secondary peroxidase/oxidase activity: The aerobic reaction with isobutanal, enhanced by hydrogen peroxide as a cosubstrate, yields acetone, exhibits chemiluminescence and consumes oxygen (phi cl = 1.3 x 10(-9) photons/O2 molecule consumed).	Oxygen	248-250	linoleate 9S-lipoxygenase-4	Glycine max	8-20
2502778-3	1989	In the presence of hydrogen peroxide the lipoxygenase reaction with glutathione yields yet another excited state.	Hydrogen Peroxide	19-36	linoleate 9S-lipoxygenase-4	Glycine max	41-53
2502778-3	1989	In the presence of hydrogen peroxide the lipoxygenase reaction with glutathione yields yet another excited state.	Glutathione	68-79	linoleate 9S-lipoxygenase-4	Glycine max	41-53
2502778-5	1989	With isobutanal as a substrate lipoxygenase acts as an oxidase and as a peroxidase.	isobutyraldehyde	5-15	linoleate 9S-lipoxygenase-4	Glycine max	31-43
2502779-2	1989	During the aerobic reaction of soybean lipoxygenase with polyunsaturated fatty acids (linoleic, linolenic, and arachidonic acid) oxygen uptake is followed by excited carbonyl photoemission.	Fatty Acids, Unsaturated	57-84	linoleate 9S-lipoxygenase-4	Glycine max	39-51
2502779-2	1989	During the aerobic reaction of soybean lipoxygenase with polyunsaturated fatty acids (linoleic, linolenic, and arachidonic acid) oxygen uptake is followed by excited carbonyl photoemission.	Linoleic Acid	86-94	linoleate 9S-lipoxygenase-4	Glycine max	39-51
2502779-2	1989	During the aerobic reaction of soybean lipoxygenase with polyunsaturated fatty acids (linoleic, linolenic, and arachidonic acid) oxygen uptake is followed by excited carbonyl photoemission.	linolenic	96-105	linoleate 9S-lipoxygenase-4	Glycine max	39-51
2502779-2	1989	During the aerobic reaction of soybean lipoxygenase with polyunsaturated fatty acids (linoleic, linolenic, and arachidonic acid) oxygen uptake is followed by excited carbonyl photoemission.	Arachidonic Acid	111-127	linoleate 9S-lipoxygenase-4	Glycine max	39-51
2502779-5	1989	When 1 mM glutathione is added to the aerobic lipoxygenase/arachidonate reaction, carbonyl emission (375-455 nm) is replaced by intense red bands (630-645 nm and 695-715 nm) resembling the characteristic spectrum of (1 delta g)O2-singlet oxygen dimol-emission.	Glutathione	10-21	linoleate 9S-lipoxygenase-4	Glycine max	46-58
2502779-5	1989	When 1 mM glutathione is added to the aerobic lipoxygenase/arachidonate reaction, carbonyl emission (375-455 nm) is replaced by intense red bands (630-645 nm and 695-715 nm) resembling the characteristic spectrum of (1 delta g)O2-singlet oxygen dimol-emission.	Arachidonic Acid	59-71	linoleate 9S-lipoxygenase-4	Glycine max	46-58
2502779-5	1989	When 1 mM glutathione is added to the aerobic lipoxygenase/arachidonate reaction, carbonyl emission (375-455 nm) is replaced by intense red bands (630-645 nm and 695-715 nm) resembling the characteristic spectrum of (1 delta g)O2-singlet oxygen dimol-emission.	oxygen dimol	238-250	linoleate 9S-lipoxygenase-4	Glycine max	46-58
3122822-0	1987	Oxygenation of trans polyunsaturated fatty acids by lipoxygenase reveals steric features of the catalytic mechanism.	trans polyunsaturated fatty acids	15-48	linoleate 9S-lipoxygenase-4	Glycine max	52-64
24212490-7	1989	Isotope discrimination by soybean lipoxygenase (EC 1.13.11.12) supplied with linoleic acid was much lower than by respiration.	Linoleic Acid	77-90	linoleate 9S-lipoxygenase-4	Glycine max	34-46
2539142-1	1989	Incubation of gamma-linolenic acid with soybean lipoxygenase initially at pH 9.3 and subsequently at pH 7.9 gave rise to the conjugated triene dioxygenation product (lambda max = 267 nm, greater than 50% yield), which was reduced to form 9-cis isomer of 6,13-dihydroxyoctadecatrienoic acid (6,13-diHOT) accompanied by minor isomers.	gamma-Linolenic Acid	14-34	linoleate 9S-lipoxygenase-4	Glycine max	48-60
2539142-1	1989	Incubation of gamma-linolenic acid with soybean lipoxygenase initially at pH 9.3 and subsequently at pH 7.9 gave rise to the conjugated triene dioxygenation product (lambda max = 267 nm, greater than 50% yield), which was reduced to form 9-cis isomer of 6,13-dihydroxyoctadecatrienoic acid (6,13-diHOT) accompanied by minor isomers.	TRIETHYLENETETRAMINE	136-142	linoleate 9S-lipoxygenase-4	Glycine max	48-60
2539142-1	1989	Incubation of gamma-linolenic acid with soybean lipoxygenase initially at pH 9.3 and subsequently at pH 7.9 gave rise to the conjugated triene dioxygenation product (lambda max = 267 nm, greater than 50% yield), which was reduced to form 9-cis isomer of 6,13-dihydroxyoctadecatrienoic acid (6,13-diHOT) accompanied by minor isomers.	6,13-dihydroxyoctadecatrienoic acid	254-289	linoleate 9S-lipoxygenase-4	Glycine max	48-60
2539142-1	1989	Incubation of gamma-linolenic acid with soybean lipoxygenase initially at pH 9.3 and subsequently at pH 7.9 gave rise to the conjugated triene dioxygenation product (lambda max = 267 nm, greater than 50% yield), which was reduced to form 9-cis isomer of 6,13-dihydroxyoctadecatrienoic acid (6,13-diHOT) accompanied by minor isomers.	6,13-dihydroxyoctadecatrienoic acid	291-301	linoleate 9S-lipoxygenase-4	Glycine max	48-60
2471340-0	1989	[Activity of lipoxygenase incorporated into reversed micelles of aerosol OT in octane].	octane	79-85	linoleate 9S-lipoxygenase-4	Glycine max	13-25
2471340-1	1989	Soybean lipoxygenase (EC 1.13.11.12) incorporated into the reversed micelles of aerosol OT in octane has been studied for its catalytic properties.	octane	94-100	linoleate 9S-lipoxygenase-4	Glycine max	8-20
2471340-3	1989	In this case Km of lipoxygenase for linoleic acid increases from 10(-5) M to 5 X 10(-4) M. The activity of lipoxygenase is maximal, the aerosol OT concentration being 0.03 M and a degree of reversed micelle hydratation 40.	Linoleic Acid	36-49	linoleate 9S-lipoxygenase-4	Glycine max	19-31
2471340-3	1989	In this case Km of lipoxygenase for linoleic acid increases from 10(-5) M to 5 X 10(-4) M. The activity of lipoxygenase is maximal, the aerosol OT concentration being 0.03 M and a degree of reversed micelle hydratation 40.	Linoleic Acid	36-49	linoleate 9S-lipoxygenase-4	Glycine max	107-119
2492826-7	1989	Methyl esterification of linoleic acid blocked the formation of the (9S)-hydroperoxide by lipoxygenase-1, but not the (13S)-hydroperoxide.	Linoleic Acid	25-38	linoleate 9S-lipoxygenase-4	Glycine max	90-102
2492826-7	1989	Methyl esterification of linoleic acid blocked the formation of the (9S)-hydroperoxide by lipoxygenase-1, but not the (13S)-hydroperoxide.	(9s)-hydroperoxide	68-86	linoleate 9S-lipoxygenase-4	Glycine max	90-102
2541151-1	1989	In the reaction of soybean lipoxygenase (EC 1.13.11.12) with polyunsaturated fatty acids such as linoleic, linolenic and arachidonic acids, some radical species were detected using the electron spin resonance (ESR) spin-trapping technique.	Fatty Acids, Unsaturated	61-88	linoleate 9S-lipoxygenase-4	Glycine max	27-39
2541151-1	1989	In the reaction of soybean lipoxygenase (EC 1.13.11.12) with polyunsaturated fatty acids such as linoleic, linolenic and arachidonic acids, some radical species were detected using the electron spin resonance (ESR) spin-trapping technique.	Linoleic Acid	97-105	linoleate 9S-lipoxygenase-4	Glycine max	27-39
2541151-1	1989	In the reaction of soybean lipoxygenase (EC 1.13.11.12) with polyunsaturated fatty acids such as linoleic, linolenic and arachidonic acids, some radical species were detected using the electron spin resonance (ESR) spin-trapping technique.	linolenic	107-116	linoleate 9S-lipoxygenase-4	Glycine max	27-39
2541151-1	1989	In the reaction of soybean lipoxygenase (EC 1.13.11.12) with polyunsaturated fatty acids such as linoleic, linolenic and arachidonic acids, some radical species were detected using the electron spin resonance (ESR) spin-trapping technique.	Arachidonic Acids	121-138	linoleate 9S-lipoxygenase-4	Glycine max	27-39
3144281-0	1988	Inactivation of soybean lipoxygenase by lipoxygenase inhibitors in the presence of 15-hydroperoxyeicosatetraenoic acid.	15-hydroperoxyeicosatetraenoic acid	83-118	linoleate 9S-lipoxygenase-4	Glycine max	24-36
3144281-0	1988	Inactivation of soybean lipoxygenase by lipoxygenase inhibitors in the presence of 15-hydroperoxyeicosatetraenoic acid.	15-hydroperoxyeicosatetraenoic acid	83-118	linoleate 9S-lipoxygenase-4	Glycine max	40-52
3144281-1	1988	Soybean lipoxygenase is rapidly inactivated when incubated with arachidonic acid and any of several lipoxygenase inhibitors, including NDGA, the aminopyrazolines BW 755C and BW 540C, and the acetohydroxamic acid derivatives BW A4C and BW A137C.	Arachidonic Acid	64-80	linoleate 9S-lipoxygenase-4	Glycine max	8-20
3144281-1	1988	Soybean lipoxygenase is rapidly inactivated when incubated with arachidonic acid and any of several lipoxygenase inhibitors, including NDGA, the aminopyrazolines BW 755C and BW 540C, and the acetohydroxamic acid derivatives BW A4C and BW A137C.	Masoprocol	135-139	linoleate 9S-lipoxygenase-4	Glycine max	8-20
3144281-1	1988	Soybean lipoxygenase is rapidly inactivated when incubated with arachidonic acid and any of several lipoxygenase inhibitors, including NDGA, the aminopyrazolines BW 755C and BW 540C, and the acetohydroxamic acid derivatives BW A4C and BW A137C.	aminopyrazolines	145-161	linoleate 9S-lipoxygenase-4	Glycine max	8-20
3144281-1	1988	Soybean lipoxygenase is rapidly inactivated when incubated with arachidonic acid and any of several lipoxygenase inhibitors, including NDGA, the aminopyrazolines BW 755C and BW 540C, and the acetohydroxamic acid derivatives BW A4C and BW A137C.	acetohydroxamic acid	191-211	linoleate 9S-lipoxygenase-4	Glycine max	8-20
3144281-4	1988	The UV absorption at 235 nm, due to the conjugated diene in 15-HPETE or 13-HPOD, was rapidly destroyed in the presence of soybean lipoxygenase and inhibitor in a presumed pseudoperoxidase reaction.	diene	51-56	linoleate 9S-lipoxygenase-4	Glycine max	130-142
3144281-5	1988	The products of the reaction between linoleic acid, BW A137C and soybean lipoxygenase have been partially characterized.	Linoleic Acid	37-50	linoleate 9S-lipoxygenase-4	Glycine max	73-85
3149509-1	1988	Soybean lipoxygenase was assayed under conditions such that the concentration of the enzyme was in excess of the concentration of the substrate, arachidonic acid.	Arachidonic Acid	145-161	linoleate 9S-lipoxygenase-4	Glycine max	8-20
3138991-0	1988	Hydroperoxidase activity of lipoxygenase: hydrogen peroxide-dependent oxidation of xenobiotics.	Hydrogen Peroxide	42-59	linoleate 9S-lipoxygenase-4	Glycine max	28-40
3138991-1	1988	Since H2O2 is one of the major biologically available peroxides, its ability to support hydroperoxidase activity of highly purified soybean lipoxygenase was examined by monitoring co-oxidation of selected xenobiotics.	Hydrogen Peroxide	6-10	linoleate 9S-lipoxygenase-4	Glycine max	140-152
3138991-1	1988	Since H2O2 is one of the major biologically available peroxides, its ability to support hydroperoxidase activity of highly purified soybean lipoxygenase was examined by monitoring co-oxidation of selected xenobiotics.	Peroxides	54-63	linoleate 9S-lipoxygenase-4	Glycine max	140-152
3138991-3	1988	Tetramethylbenzidine oxidation was completely inhibited by the classical lipoxygenase inhibitor nordihydroguaiaretic acid.	3,3',5,5'-tetramethylbenzidine	0-20	linoleate 9S-lipoxygenase-4	Glycine max	73-85
3138991-3	1988	Tetramethylbenzidine oxidation was completely inhibited by the classical lipoxygenase inhibitor nordihydroguaiaretic acid.	Masoprocol	96-121	linoleate 9S-lipoxygenase-4	Glycine max	73-85
3138991-5	1988	The data clearly indicate, for the first time, that H2O2 can efficiently replace fatty acid hydroperoxide in a xenobiotic oxidation reaction medicated by the hydroperoxidase activity of lipoxygenase.	Hydrogen Peroxide	52-56	linoleate 9S-lipoxygenase-4	Glycine max	186-198
3138991-5	1988	The data clearly indicate, for the first time, that H2O2 can efficiently replace fatty acid hydroperoxide in a xenobiotic oxidation reaction medicated by the hydroperoxidase activity of lipoxygenase.	Lipid Peroxides	81-105	linoleate 9S-lipoxygenase-4	Glycine max	186-198
3132921-0	1988	Soybean lipoxygenase-catalyzed formation of lipoxin A and lipoxin B isomers from arachidonic acid via 5,15-dihydroperoxyeicosatetraenoic acid.	lipoxin A4	44-53	linoleate 9S-lipoxygenase-4	Glycine max	8-20
3132921-0	1988	Soybean lipoxygenase-catalyzed formation of lipoxin A and lipoxin B isomers from arachidonic acid via 5,15-dihydroperoxyeicosatetraenoic acid.	Lipoxin B	58-67	linoleate 9S-lipoxygenase-4	Glycine max	8-20
3132921-0	1988	Soybean lipoxygenase-catalyzed formation of lipoxin A and lipoxin B isomers from arachidonic acid via 5,15-dihydroperoxyeicosatetraenoic acid.	Arachidonic Acid	81-97	linoleate 9S-lipoxygenase-4	Glycine max	8-20
3132921-0	1988	Soybean lipoxygenase-catalyzed formation of lipoxin A and lipoxin B isomers from arachidonic acid via 5,15-dihydroperoxyeicosatetraenoic acid.	5,15-dihydroperoxyeicosatetraenoic acid	102-141	linoleate 9S-lipoxygenase-4	Glycine max	8-20
3132921-1	1988	Soybean lipoxygenase converted arachidonic acid to a group of polar products (lambda max, 300-301 nm), which were increasingly formed during the continued incubation at 20 degrees C after the initial incubation (2 hrs, at 4 degrees C).	Arachidonic Acid	31-47	linoleate 9S-lipoxygenase-4	Glycine max	8-20
3132921-4	1988	The exposure of 5,15-dihydroperoxyeicosatetraenoic acid to the soybean lipoxygenase produced the identical product profile of chromatography, substantiating the intermediacy of 5,15-dihydroperoxyeicosatetraenoic acid in the soybean lipoxygenase-catalyzed formation of lipoxins.	5,15-dihydroperoxyeicosatetraenoic acid	16-55	linoleate 9S-lipoxygenase-4	Glycine max	71-83
3132921-4	1988	The exposure of 5,15-dihydroperoxyeicosatetraenoic acid to the soybean lipoxygenase produced the identical product profile of chromatography, substantiating the intermediacy of 5,15-dihydroperoxyeicosatetraenoic acid in the soybean lipoxygenase-catalyzed formation of lipoxins.	5,15-dihydroperoxyeicosatetraenoic acid	16-55	linoleate 9S-lipoxygenase-4	Glycine max	232-244
3132921-4	1988	The exposure of 5,15-dihydroperoxyeicosatetraenoic acid to the soybean lipoxygenase produced the identical product profile of chromatography, substantiating the intermediacy of 5,15-dihydroperoxyeicosatetraenoic acid in the soybean lipoxygenase-catalyzed formation of lipoxins.	5,15-dihydroperoxyeicosatetraenoic acid	177-216	linoleate 9S-lipoxygenase-4	Glycine max	71-83
3132921-4	1988	The exposure of 5,15-dihydroperoxyeicosatetraenoic acid to the soybean lipoxygenase produced the identical product profile of chromatography, substantiating the intermediacy of 5,15-dihydroperoxyeicosatetraenoic acid in the soybean lipoxygenase-catalyzed formation of lipoxins.	Lipoxins	268-276	linoleate 9S-lipoxygenase-4	Glycine max	71-83
3132921-5	1988	Based on these results, it is proposed that the conversion of arachidonic acid into lipoxins by soybean lipoxygenase may bear a mechanistic resemblance to the formation of lipoxins in the human leukocytes.	Arachidonic Acid	62-78	linoleate 9S-lipoxygenase-4	Glycine max	104-116
3132921-5	1988	Based on these results, it is proposed that the conversion of arachidonic acid into lipoxins by soybean lipoxygenase may bear a mechanistic resemblance to the formation of lipoxins in the human leukocytes.	Lipoxins	84-92	linoleate 9S-lipoxygenase-4	Glycine max	104-116
3132921-5	1988	Based on these results, it is proposed that the conversion of arachidonic acid into lipoxins by soybean lipoxygenase may bear a mechanistic resemblance to the formation of lipoxins in the human leukocytes.	Lipoxins	172-180	linoleate 9S-lipoxygenase-4	Glycine max	104-116
3122826-0	1987	Reductive inactivation of soybean lipoxygenase 1 by catechols: a possible mechanism for regulation of lipoxygenase activity.	Catechols	52-61	linoleate 9S-lipoxygenase-4	Glycine max	34-46
3122826-5	1987	Lipoxygenase catalyzes the oxidation of NDGA by LOOH at a rate that is consistent with the independently determined rate constant for the reduction of Eox by NDGA.	Lipid Peroxides	48-52	linoleate 9S-lipoxygenase-4	Glycine max	0-12
3122826-5	1987	Lipoxygenase catalyzes the oxidation of NDGA by LOOH at a rate that is consistent with the independently determined rate constant for the reduction of Eox by NDGA.	eox	151-154	linoleate 9S-lipoxygenase-4	Glycine max	0-12
3122826-7	1987	Because the catalytically inactive Ered is oxidized by fatty acid hydroperoxides (e.g., LOOH) to give the active Eox, reducing agents such as NDGA are most effective as lipoxygenase inhibitors at low hydroperoxide concentrations.	Lipid Peroxides	55-80	linoleate 9S-lipoxygenase-4	Glycine max	169-181
3122826-7	1987	Because the catalytically inactive Ered is oxidized by fatty acid hydroperoxides (e.g., LOOH) to give the active Eox, reducing agents such as NDGA are most effective as lipoxygenase inhibitors at low hydroperoxide concentrations.	Lipid Peroxides	88-92	linoleate 9S-lipoxygenase-4	Glycine max	169-181
3122826-7	1987	Because the catalytically inactive Ered is oxidized by fatty acid hydroperoxides (e.g., LOOH) to give the active Eox, reducing agents such as NDGA are most effective as lipoxygenase inhibitors at low hydroperoxide concentrations.	Masoprocol	142-146	linoleate 9S-lipoxygenase-4	Glycine max	169-181
3122826-8	1987	Our results suggest that in vivo, where lipid hydroperoxides are maintained at low steady-state levels, reduction of lipoxygenase from the ferric to ferrous state may be important in the regulation of lipoxygenase activity and hence leukotriene biosynthesis.	Lipid Peroxides	40-60	linoleate 9S-lipoxygenase-4	Glycine max	117-129
2494999-0	1989	Lipoxygenase-catalyzed epoxidation of benzo(a)pyrene-7,8-dihydrodiol.	benzo(a)pyrene 7,8-dihydrodiol	38-68	linoleate 9S-lipoxygenase-4	Glycine max	0-12
2494999-1	1989	Metabolism of resolved radioactive stereoisomer, [14C](+)-benzo-(a)pyrene-trans-7,8-dihydrodiol by highly purified soybean lipoxygenase plus linoleic acid was investigated.	[14c](+)-benzo-(a)pyrene-trans-7,8-dihydrodiol	49-95	linoleate 9S-lipoxygenase-4	Glycine max	123-135
2494999-4	1989	This study provides evidence on the ability of lipoxygenase to catalyze the epoxidation of benzo(a)pyrene-7,8-dihydrodiol.	benzo(a)pyrene 7,8-dihydrodiol	91-121	linoleate 9S-lipoxygenase-4	Glycine max	47-59
2497775-1	1989	Isotope effects for the oxidation of [5,6,8,9,11,12,14,15-3H]arachidonic acid catalyzed by soybean lipoxygenase and by 5-lipoxygenase were measured.	[5,6,8,9,11,12,14,15-3h]arachidonic acid	37-77	linoleate 9S-lipoxygenase-4	Glycine max	99-111
3136803-1	1988	The iron coordination in native, Fe(II), lipoxygenase has been studied by Extended X-Ray Absorption Fine Structure (EXAFS).	Iron	4-8	linoleate 9S-lipoxygenase-4	Glycine max	33-53
2840081-4	1988	This was equipotent in our system with the known lipoxygenase inhibitor nordihydroguaiaretic acid (NDGA).	Masoprocol	72-97	linoleate 9S-lipoxygenase-4	Glycine max	49-61
2840081-4	1988	This was equipotent in our system with the known lipoxygenase inhibitor nordihydroguaiaretic acid (NDGA).	Masoprocol	99-103	linoleate 9S-lipoxygenase-4	Glycine max	49-61
2840081-6	1988	Manoalide showed some activity against soybean lipoxygenase, although it was 30- to 50-fold less potent than as an inhibitor of the 5-lipoxygenase enzyme.	manoalide	0-9	linoleate 9S-lipoxygenase-4	Glycine max	47-59
3128297-9	1988	Quercetin was the most potent and it inhibited the lipoxygenase in the liposomal suspension by about 42% while the other flavonoids inhibited the enzyme by about 14-23%.	Quercetin	0-9	linoleate 9S-lipoxygenase-4	Glycine max	51-63
2969420-2	1988	Oxidation products of linoleic and arachidonic acids, obtained either by autoxidation or incubation with soybean lipoxygenase, effectively blocked in a dose-dependent manner, the net influx of calcium in the absence or presence of 5 mM of oxalate.	Linoleic Acid	22-30	linoleate 9S-lipoxygenase-4	Glycine max	113-125
2969420-2	1988	Oxidation products of linoleic and arachidonic acids, obtained either by autoxidation or incubation with soybean lipoxygenase, effectively blocked in a dose-dependent manner, the net influx of calcium in the absence or presence of 5 mM of oxalate.	Arachidonic Acids	35-52	linoleate 9S-lipoxygenase-4	Glycine max	113-125
2969420-2	1988	Oxidation products of linoleic and arachidonic acids, obtained either by autoxidation or incubation with soybean lipoxygenase, effectively blocked in a dose-dependent manner, the net influx of calcium in the absence or presence of 5 mM of oxalate.	Calcium	193-200	linoleate 9S-lipoxygenase-4	Glycine max	113-125
2969420-2	1988	Oxidation products of linoleic and arachidonic acids, obtained either by autoxidation or incubation with soybean lipoxygenase, effectively blocked in a dose-dependent manner, the net influx of calcium in the absence or presence of 5 mM of oxalate.	Oxalates	239-246	linoleate 9S-lipoxygenase-4	Glycine max	113-125
2969420-3	1988	Unoxidized fatty acids were much weaker at lower concentrations as compared to their oxidized counterparts, except the lipoxygenase-generated product of arachidonic acid which had only a marginal effect even at high concentrations.	Arachidonic Acid	153-169	linoleate 9S-lipoxygenase-4	Glycine max	119-131
2969420-5	1988	Likewise, autoxidation products of linoleic and arachidonic acids and lipoxygenase-generated products of linoleic acid induced a dose-dependent release of calcium from vesicles previously loaded with 45Ca, and release was further enhanced in the presence of 0.5 mM of EGTA.	Linoleic Acid	105-118	linoleate 9S-lipoxygenase-4	Glycine max	70-82
2969420-5	1988	Likewise, autoxidation products of linoleic and arachidonic acids and lipoxygenase-generated products of linoleic acid induced a dose-dependent release of calcium from vesicles previously loaded with 45Ca, and release was further enhanced in the presence of 0.5 mM of EGTA.	Calcium	155-162	linoleate 9S-lipoxygenase-4	Glycine max	70-82
2969420-5	1988	Likewise, autoxidation products of linoleic and arachidonic acids and lipoxygenase-generated products of linoleic acid induced a dose-dependent release of calcium from vesicles previously loaded with 45Ca, and release was further enhanced in the presence of 0.5 mM of EGTA.	Egtazic Acid	268-272	linoleate 9S-lipoxygenase-4	Glycine max	70-82
2969420-6	1988	In contrast, lipoxygenase metabolites of arachidonic acid caused a transient increase in net calcium content.	Arachidonic Acid	41-57	linoleate 9S-lipoxygenase-4	Glycine max	13-25
2969420-6	1988	In contrast, lipoxygenase metabolites of arachidonic acid caused a transient increase in net calcium content.	Calcium	93-100	linoleate 9S-lipoxygenase-4	Glycine max	13-25
3122822-1	1987	Lipoxygenase, a nonheme iron dioxygenase, catalyzes the oxygenation of 1,4-diene units in polyunsaturated fatty acids, forming conjugated diene hydroperoxides as the primary products.	1,4-diene	71-80	linoleate 9S-lipoxygenase-4	Glycine max	0-12
3122822-1	1987	Lipoxygenase, a nonheme iron dioxygenase, catalyzes the oxygenation of 1,4-diene units in polyunsaturated fatty acids, forming conjugated diene hydroperoxides as the primary products.	Fatty Acids, Unsaturated	90-117	linoleate 9S-lipoxygenase-4	Glycine max	0-12
3122822-1	1987	Lipoxygenase, a nonheme iron dioxygenase, catalyzes the oxygenation of 1,4-diene units in polyunsaturated fatty acids, forming conjugated diene hydroperoxides as the primary products.	diene hydroperoxides	138-158	linoleate 9S-lipoxygenase-4	Glycine max	0-12
3040731-0	1987	The nitric oxide complex of ferrous soybean lipoxygenase-1.	Nitric Oxide	4-16	linoleate 9S-lipoxygenase-4	Glycine max	44-56
3040731-2	1987	Soybean lipoxygenase is a non-heme iron enzyme that catalyzes the hydroperoxidation of linoleic acid by dioxygen.	Iron	35-39	linoleate 9S-lipoxygenase-4	Glycine max	8-20
3040731-2	1987	Soybean lipoxygenase is a non-heme iron enzyme that catalyzes the hydroperoxidation of linoleic acid by dioxygen.	Linoleic Acid	87-100	linoleate 9S-lipoxygenase-4	Glycine max	8-20
3040731-2	1987	Soybean lipoxygenase is a non-heme iron enzyme that catalyzes the hydroperoxidation of linoleic acid by dioxygen.	Oxygen	104-112	linoleate 9S-lipoxygenase-4	Glycine max	8-20
3040731-3	1987	Exposure of ferrous lipoxygenase to nitric oxide yields a species displaying an electron paramagnetic resonance spectrum characteristic of a nearly axial S = 3/2 electronic spin system arising from the ferrous-nitrosyl complex.	Nitric Oxide	36-48	linoleate 9S-lipoxygenase-4	Glycine max	20-32
3040731-3	1987	Exposure of ferrous lipoxygenase to nitric oxide yields a species displaying an electron paramagnetic resonance spectrum characteristic of a nearly axial S = 3/2 electronic spin system arising from the ferrous-nitrosyl complex.	ferrous-nitrosyl	202-218	linoleate 9S-lipoxygenase-4	Glycine max	20-32
3116881-0	1987	Product yield in oxygenation of linoleate by soybean lipoxygenase: the value of the molar extinction coefficient in the spectrophotometric assay.	Linoleic Acid	32-41	linoleate 9S-lipoxygenase-4	Glycine max	53-65
3116881-1	1987	Two iodimetric methods and a gravimetric method were used to determine the spectrophotometric molar absorptivity of the purified product of lipoxygenase-catalyzed dioxygenation of linoleate (13-LS-hydroperoxy-cis,trans-9,11-octadecadienoate).	dioxygenation	163-176	linoleate 9S-lipoxygenase-4	Glycine max	140-152
3116881-1	1987	Two iodimetric methods and a gravimetric method were used to determine the spectrophotometric molar absorptivity of the purified product of lipoxygenase-catalyzed dioxygenation of linoleate (13-LS-hydroperoxy-cis,trans-9,11-octadecadienoate).	Linoleic Acid	180-189	linoleate 9S-lipoxygenase-4	Glycine max	140-152
3116881-1	1987	Two iodimetric methods and a gravimetric method were used to determine the spectrophotometric molar absorptivity of the purified product of lipoxygenase-catalyzed dioxygenation of linoleate (13-LS-hydroperoxy-cis,trans-9,11-octadecadienoate).	13-ls-hydroperoxy-cis	191-212	linoleate 9S-lipoxygenase-4	Glycine max	140-152
3116881-1	1987	Two iodimetric methods and a gravimetric method were used to determine the spectrophotometric molar absorptivity of the purified product of lipoxygenase-catalyzed dioxygenation of linoleate (13-LS-hydroperoxy-cis,trans-9,11-octadecadienoate).	trans-9,11-octadecadienoate	213-240	linoleate 9S-lipoxygenase-4	Glycine max	140-152
3116881-4	1987	Final 235-nm absorbancies for lipoxygenase runs over a wide range of linoleic acid concentrations up to 200 microM give a constant final percentage completion.	Linoleic Acid	69-82	linoleate 9S-lipoxygenase-4	Glycine max	30-42
3116881-8	1987	Above 200 microM linoleate, yields at 235 nm decrease and yields of materials absorbing at 280 nm increase (the latter is known to arise from lipoxygenase-catalyzed reaction of linoleyl hydroperoxide).	Linoleic Acid	17-26	linoleate 9S-lipoxygenase-4	Glycine max	142-154
3116881-8	1987	Above 200 microM linoleate, yields at 235 nm decrease and yields of materials absorbing at 280 nm increase (the latter is known to arise from lipoxygenase-catalyzed reaction of linoleyl hydroperoxide).	linoleyl hydroperoxide	177-199	linoleate 9S-lipoxygenase-4	Glycine max	142-154
3026385-5	1986	To establish the presence of [17O2]oxygen in our incubations, a portion of the gas from the lipoxygenase/linoleate experiments was used to prepare the 4-POBN-superoxide radical adduct utilizing a superoxide producing microsomal/paraquat/NADPH system.	Superoxides	158-168	linoleate 9S-lipoxygenase-4	Glycine max	92-104
3304843-10	1987	The presence of hydrogen peroxide, especially hydroperoxides, activates enzymes such as cyclooxygenase and lipoxygenase.	Hydrogen Peroxide	16-33	linoleate 9S-lipoxygenase-4	Glycine max	107-119
3304843-10	1987	The presence of hydrogen peroxide, especially hydroperoxides, activates enzymes such as cyclooxygenase and lipoxygenase.	Hydrogen Peroxide	46-60	linoleate 9S-lipoxygenase-4	Glycine max	107-119
3304843-21	1987	The classical soybean lipoxygenase inhibitors are antioxidants, such as nordihydroguaiaretic acid (NDGA) and others, and the substrate analog 5,8,11,14 eicosatetraynoic acid (ETYA), which also inhibit cyclooxygenase (g).	Masoprocol	72-97	linoleate 9S-lipoxygenase-4	Glycine max	22-34
3304843-21	1987	The classical soybean lipoxygenase inhibitors are antioxidants, such as nordihydroguaiaretic acid (NDGA) and others, and the substrate analog 5,8,11,14 eicosatetraynoic acid (ETYA), which also inhibit cyclooxygenase (g).	Masoprocol	99-103	linoleate 9S-lipoxygenase-4	Glycine max	22-34
3304843-21	1987	The classical soybean lipoxygenase inhibitors are antioxidants, such as nordihydroguaiaretic acid (NDGA) and others, and the substrate analog 5,8,11,14 eicosatetraynoic acid (ETYA), which also inhibit cyclooxygenase (g).	ETYA	152-173	linoleate 9S-lipoxygenase-4	Glycine max	22-34
3304843-21	1987	The classical soybean lipoxygenase inhibitors are antioxidants, such as nordihydroguaiaretic acid (NDGA) and others, and the substrate analog 5,8,11,14 eicosatetraynoic acid (ETYA), which also inhibit cyclooxygenase (g).	ETYA	175-179	linoleate 9S-lipoxygenase-4	Glycine max	22-34
3026385-0	1986	A search for oxygen-centered free radicals in the lipoxygenase/linoleic acid system.	Oxygen	13-19	linoleate 9S-lipoxygenase-4	Glycine max	50-62
3026385-0	1986	A search for oxygen-centered free radicals in the lipoxygenase/linoleic acid system.	Linoleic Acid	63-76	linoleate 9S-lipoxygenase-4	Glycine max	50-62
3026385-1	1986	Studies of the oxygenation of linoleic acid by soybean lipoxygenase utilizing electron spin resonance spectroscopy and oxygen uptake have been undertaken.	Linoleic Acid	30-43	linoleate 9S-lipoxygenase-4	Glycine max	55-67
3026385-1	1986	Studies of the oxygenation of linoleic acid by soybean lipoxygenase utilizing electron spin resonance spectroscopy and oxygen uptake have been undertaken.	Oxygen	15-21	linoleate 9S-lipoxygenase-4	Glycine max	55-67
3026385-2	1986	The spin trap, alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone (4-POBN) was included in the lipoxygenase system to capture short-lived free radicals.	alpha-(4-pyridyl-1-oxide)-n-t-butylnitrone	15-57	linoleate 9S-lipoxygenase-4	Glycine max	87-99
3026385-5	1986	To establish the presence of [17O2]oxygen in our incubations, a portion of the gas from the lipoxygenase/linoleate experiments was used to prepare the 4-POBN-superoxide radical adduct utilizing a superoxide producing microsomal/paraquat/NADPH system.	Superoxides	196-206	linoleate 9S-lipoxygenase-4	Glycine max	92-104
3026385-5	1986	To establish the presence of [17O2]oxygen in our incubations, a portion of the gas from the lipoxygenase/linoleate experiments was used to prepare the 4-POBN-superoxide radical adduct utilizing a superoxide producing microsomal/paraquat/NADPH system.	Paraquat	228-236	linoleate 9S-lipoxygenase-4	Glycine max	92-104
3026385-2	1986	The spin trap, alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone (4-POBN) was included in the lipoxygenase system to capture short-lived free radicals.	4-aminobenzhydrazide	59-65	linoleate 9S-lipoxygenase-4	Glycine max	87-99
3026385-5	1986	To establish the presence of [17O2]oxygen in our incubations, a portion of the gas from the lipoxygenase/linoleate experiments was used to prepare the 4-POBN-superoxide radical adduct utilizing a superoxide producing microsomal/paraquat/NADPH system.	17o2	30-34	linoleate 9S-lipoxygenase-4	Glycine max	92-104
3026385-5	1986	To establish the presence of [17O2]oxygen in our incubations, a portion of the gas from the lipoxygenase/linoleate experiments was used to prepare the 4-POBN-superoxide radical adduct utilizing a superoxide producing microsomal/paraquat/NADPH system.	Linoleic Acid	105-114	linoleate 9S-lipoxygenase-4	Glycine max	92-104
3026385-5	1986	To establish the presence of [17O2]oxygen in our incubations, a portion of the gas from the lipoxygenase/linoleate experiments was used to prepare the 4-POBN-superoxide radical adduct utilizing a superoxide producing microsomal/paraquat/NADPH system.	NADP	237-242	linoleate 9S-lipoxygenase-4	Glycine max	92-104
3026385-5	1986	To establish the presence of [17O2]oxygen in our incubations, a portion of the gas from the lipoxygenase/linoleate experiments was used to prepare the 4-POBN-superoxide radical adduct utilizing a superoxide producing microsomal/paraquat/NADPH system.	4-aminobenzhydrazide	151-157	linoleate 9S-lipoxygenase-4	Glycine max	92-104
16665148-6	1986	The incorporation of iron-59 from the nutrient medium into lipoxygenase during culture of immature seeds was indicative of de novo synthesis of the enzyme.	Iron	21-25	linoleate 9S-lipoxygenase-4	Glycine max	59-71
16665148-7	1986	The efficiency of the iron uptake was high, as indicated by the level of radioactivity found in the enzyme (one gram atom of iron per mole of lipoxygenase).	Iron	22-26	linoleate 9S-lipoxygenase-4	Glycine max	142-154
3105349-0	1987	Analysis of the stereochemistry of lipoxygenase-derived hydroxypolyenoic fatty acids by means of chiral phase high-pressure liquid chromatography.	hydroxypolyenoic fatty acids	56-84	linoleate 9S-lipoxygenase-4	Glycine max	35-47
16665148-7	1986	The efficiency of the iron uptake was high, as indicated by the level of radioactivity found in the enzyme (one gram atom of iron per mole of lipoxygenase).	Iron	125-129	linoleate 9S-lipoxygenase-4	Glycine max	142-154
3017277-5	1986	The ESR signal was, however, inhibited by the lipoxygenase inhibitors nordihydroguaiaretic acid and N-ethylmaleimide.	Masoprocol	70-95	linoleate 9S-lipoxygenase-4	Glycine max	46-58
3105349-1	1987	A chiral phase HPLC method was developed for the simultaneous determination of the positional and optical isomers of the lipoxygenase-derived hydroxypolyenoic fatty acids.	hydroxypolyenoic fatty acids	142-170	linoleate 9S-lipoxygenase-4	Glycine max	121-133
3106941-1	1986	Twenty flavonoids isolated from plants or transformed into methyl or acetyl derivatives were tested with regard to their influence on cyclooxygenase from the ram seminal vesicle microsomes and lipoxygenase from soya beans.	Flavonoids	7-17	linoleate 9S-lipoxygenase-4	Glycine max	193-205
3106941-3	1986	Only rhamnetin and myricetin inhibited the soybean lipoxygenase.	rhamnetin	5-14	linoleate 9S-lipoxygenase-4	Glycine max	51-63
3106941-3	1986	Only rhamnetin and myricetin inhibited the soybean lipoxygenase.	myricetin	19-28	linoleate 9S-lipoxygenase-4	Glycine max	51-63
3106941-6	1986	Structural requirements for the cyclooxygenase stimulation, lipoxygenase inhibition and antioxidant properties were different in the case of the twenty tested flavonoids.	Flavonoids	159-169	linoleate 9S-lipoxygenase-4	Glycine max	60-72
3101541-0	1986	Determination of stereochemistry in the fatty acid hydroperoxide products of lipoxygenase catalysis.	Lipid Peroxides	40-64	linoleate 9S-lipoxygenase-4	Glycine max	77-89
3101541-1	1986	High-performance liquid chromatography has been found to be an effective method for the determination of absolute configuration in the products of the lipoxygenase-catalyzed oxygenation of polyunsaturated fatty acids.	Fatty Acids, Unsaturated	189-216	linoleate 9S-lipoxygenase-4	Glycine max	151-163
3101541-6	1986	In addition, the chromatography of the derivatives obtained from lipoxygenase catalysis on arachidonic acid was found to be effective for the assignment of stereochemistry in those products.	Arachidonic Acid	91-107	linoleate 9S-lipoxygenase-4	Glycine max	65-77
3017277-5	1986	The ESR signal was, however, inhibited by the lipoxygenase inhibitors nordihydroguaiaretic acid and N-ethylmaleimide.	Ethylmaleimide	100-116	linoleate 9S-lipoxygenase-4	Glycine max	46-58
3017277-6	1986	The involvement of lipoxygenase in the production of hydroxyl radical was demonstrated by the trapping of the radical with DMPO in a reaction mixture of soybean lipoxygenase and arachidonic acid (AA).	Hydroxyl Radical	53-69	linoleate 9S-lipoxygenase-4	Glycine max	19-31
3017277-6	1986	The involvement of lipoxygenase in the production of hydroxyl radical was demonstrated by the trapping of the radical with DMPO in a reaction mixture of soybean lipoxygenase and arachidonic acid (AA).	Hydroxyl Radical	53-69	linoleate 9S-lipoxygenase-4	Glycine max	161-173
3017277-6	1986	The involvement of lipoxygenase in the production of hydroxyl radical was demonstrated by the trapping of the radical with DMPO in a reaction mixture of soybean lipoxygenase and arachidonic acid (AA).	5,5-dimethyl-1-pyrroline-1-oxide	123-127	linoleate 9S-lipoxygenase-4	Glycine max	19-31
3017277-6	1986	The involvement of lipoxygenase in the production of hydroxyl radical was demonstrated by the trapping of the radical with DMPO in a reaction mixture of soybean lipoxygenase and arachidonic acid (AA).	5,5-dimethyl-1-pyrroline-1-oxide	123-127	linoleate 9S-lipoxygenase-4	Glycine max	161-173
3017277-6	1986	The involvement of lipoxygenase in the production of hydroxyl radical was demonstrated by the trapping of the radical with DMPO in a reaction mixture of soybean lipoxygenase and arachidonic acid (AA).	Arachidonic Acid	178-194	linoleate 9S-lipoxygenase-4	Glycine max	19-31
3017277-7	1986	These findings support our previous postulation that the metabolism of AA via the lipoxygenase pathway is a source of hydroxyl radical in stimulated neutrophils.	Hydroxyl Radical	118-134	linoleate 9S-lipoxygenase-4	Glycine max	82-94
3086939-0	1986	Effect of isoquinoline alkaloids on soybean lipoxygenase activity in vitro.	isoquinoline alkaloids	10-32	linoleate 9S-lipoxygenase-4	Glycine max	44-56
3086939-1	1986	Novel isoquinoline alkaloids were evaluated for their effect on the kinetics of a soybean lipoxygenase type I using linoleic acid as substrate.	isoquinoline alkaloids	6-28	linoleate 9S-lipoxygenase-4	Glycine max	90-102
3086939-1	1986	Novel isoquinoline alkaloids were evaluated for their effect on the kinetics of a soybean lipoxygenase type I using linoleic acid as substrate.	Linoleic Acid	116-129	linoleate 9S-lipoxygenase-4	Glycine max	90-102
3937844-0	1985	High-performance liquid chromatography as a tool for identification of linolenic acid hydroperoxide prepared with soybean lipoxygenase.	13-hydroperoxylinolenic acid	71-99	linoleate 9S-lipoxygenase-4	Glycine max	122-134
3080416-0	1986	Singlet oxygen production by soybean lipoxygenase isozymes.	Singlet Oxygen	0-14	linoleate 9S-lipoxygenase-4	Glycine max	37-49
3080416-1	1986	The oxidation of linoleic acid catalyzed by soybean lipoxygenase isozymes was accompanied by 1268 nm chemiluminescence characteristic of singlet oxygen.	Linoleic Acid	17-30	linoleate 9S-lipoxygenase-4	Glycine max	52-64
3080416-1	1986	The oxidation of linoleic acid catalyzed by soybean lipoxygenase isozymes was accompanied by 1268 nm chemiluminescence characteristic of singlet oxygen.	Singlet Oxygen	137-151	linoleate 9S-lipoxygenase-4	Glycine max	52-64
3937844-1	1985	Linolenic acid hydroperoxide, enzymatically produced by soybean lipoxygenase from linolenic acid, was purified by high-performance liquid chromatography (HPLC) using a Supelco LC-8 (5 microns), 22 cm X 4.6 mm I.D.	13-hydroperoxylinolenic acid	0-28	linoleate 9S-lipoxygenase-4	Glycine max	64-76
3937844-1	1985	Linolenic acid hydroperoxide, enzymatically produced by soybean lipoxygenase from linolenic acid, was purified by high-performance liquid chromatography (HPLC) using a Supelco LC-8 (5 microns), 22 cm X 4.6 mm I.D.	alpha-Linolenic Acid	82-96	linoleate 9S-lipoxygenase-4	Glycine max	64-76
3937844-4	1985	The 13-hydroperoxy linolenic acid was the major hydroperoxide produced by soybean lipoxygenase.	13-hydroperoxylinolenic acid	4-33	linoleate 9S-lipoxygenase-4	Glycine max	82-94
3937844-4	1985	The 13-hydroperoxy linolenic acid was the major hydroperoxide produced by soybean lipoxygenase.	Hydrogen Peroxide	48-61	linoleate 9S-lipoxygenase-4	Glycine max	82-94
3936118-0	1985	Inhibition of soybean lipoxygenase by SKF 525-A and metyrapone.	Proadifen	38-47	linoleate 9S-lipoxygenase-4	Glycine max	22-34
2411781-5	1985	The suggested method was used to study the inhibitory action of dihydroriboflavin esters on D-amino acid oxidase from pig kidney and soybean lipoxygenase.	dihydroriboflavin esters	64-88	linoleate 9S-lipoxygenase-4	Glycine max	141-153
3918037-3	1985	The major lipoxygenase product from washed human platelets, soybean lipoxygenase, and neonatal rat epidermal homogenate was 13-hydroxy-(5E,9Z,11E)-octadecatrienoic acid, although lesser quantities of other isomers differing in the double bond configurations were also identified by ultraviolet spectrophotometry and gas chromatography-mass spectroscopy.	13-hydroxy-(5e,9z,11e)-octadecatrienoic acid	124-168	linoleate 9S-lipoxygenase-4	Glycine max	10-22
3918037-4	1985	Topical application of the major lipoxygenase product to paws of essential fatty acid-deficient rats resulted in nearly as complete resolution of the scaly dermatitis as did the application of columbinic acid itself; the cyclooxygenase product was not at all effective.	Fatty Acids, Essential	65-85	linoleate 9S-lipoxygenase-4	Glycine max	33-45
3918037-4	1985	Topical application of the major lipoxygenase product to paws of essential fatty acid-deficient rats resulted in nearly as complete resolution of the scaly dermatitis as did the application of columbinic acid itself; the cyclooxygenase product was not at all effective.	5,9,12-octadecatrienoic acid	193-208	linoleate 9S-lipoxygenase-4	Glycine max	33-45
2936111-0	1985	Mechanisms of inactivation of soybean lipoxygenase by acetylenic fatty acids.	acetylenic fatty acids	54-76	linoleate 9S-lipoxygenase-4	Glycine max	38-50
3088613-0	1986	Flavonoid inhibition of soybean lipoxygenase.	Flavonoids	0-9	linoleate 9S-lipoxygenase-4	Glycine max	32-44
2990543-3	1985	Addition of a catalytic amount of lipoxygenase to a mixture of 13-HPOD and N-octylhydroxylamine results in consumption of approximately 1 mumol of 13-HPOD/mumol of N-octylhydroxylamine present.	13-Hpode	63-70	linoleate 9S-lipoxygenase-4	Glycine max	34-46
2990543-3	1985	Addition of a catalytic amount of lipoxygenase to a mixture of 13-HPOD and N-octylhydroxylamine results in consumption of approximately 1 mumol of 13-HPOD/mumol of N-octylhydroxylamine present.	N-octylhydroxylamine	75-95	linoleate 9S-lipoxygenase-4	Glycine max	34-46
2990543-3	1985	Addition of a catalytic amount of lipoxygenase to a mixture of 13-HPOD and N-octylhydroxylamine results in consumption of approximately 1 mumol of 13-HPOD/mumol of N-octylhydroxylamine present.	13-Hpode	147-154	linoleate 9S-lipoxygenase-4	Glycine max	34-46
2990543-3	1985	Addition of a catalytic amount of lipoxygenase to a mixture of 13-HPOD and N-octylhydroxylamine results in consumption of approximately 1 mumol of 13-HPOD/mumol of N-octylhydroxylamine present.	N-octylhydroxylamine	164-184	linoleate 9S-lipoxygenase-4	Glycine max	34-46
2990543-5	1985	Consistent with this model, the ESR signal at g = 6.1 characteristic of ferric lipoxygenase is rapidly abolished by N-octylhydroxylamine and can be regenerated by 13-HPOD.	N-octylhydroxylamine	116-136	linoleate 9S-lipoxygenase-4	Glycine max	79-91
3920681-0	1985	Inhibitory effects of tannic acid and benzophenone on soybean lipoxygenase and ram seminal vesicle cyclooxygenase.	Tannins	22-33	linoleate 9S-lipoxygenase-4	Glycine max	62-74
3920681-0	1985	Inhibitory effects of tannic acid and benzophenone on soybean lipoxygenase and ram seminal vesicle cyclooxygenase.	benzophenone	38-50	linoleate 9S-lipoxygenase-4	Glycine max	62-74
3920681-1	1985	Soybean lipoxygenase and cyclooxygenase from ram seminal vesicles were inhibited by tannic acid and the apparent ID50"s were 7.5 x 10(-7) M and 6 x 10(-6) M, respectively.	Tannins	84-95	linoleate 9S-lipoxygenase-4	Glycine max	8-20
3920681-2	1985	The inhibition of lipoxygenase by tannic acid was noncompetitive.	Tannins	34-45	linoleate 9S-lipoxygenase-4	Glycine max	18-30
3933493-7	1985	The stimulation may be brought about by facilitating the susceptibility of the fatty acids to reticulocyte lipoxygenase.	Fatty Acids	79-90	linoleate 9S-lipoxygenase-4	Glycine max	107-119
18553581-2	1985	Experimental results obtained by air drying of soybean lipoxygenase entrapped in a glucose calcium-alginate gel are in good agreement with the predicted behavior, whereas hardly any differences occur between the results obtained with the approximate method and those obtained by a numerical solution of the original model.	glucose calcium-alginate	83-107	linoleate 9S-lipoxygenase-4	Glycine max	55-67
6440614-1	1984	The oxygenation of [1-14C]-arachidonic acid by a soluble soybean lipoxygenase (E.C.1.13.11.12) preparation was determined in the presence of various cyclo-oxygenase and lipoxygenase inhibitors.	[1-14c]-arachidonic acid	19-43	linoleate 9S-lipoxygenase-4	Glycine max	65-77
6440614-1	1984	The oxygenation of [1-14C]-arachidonic acid by a soluble soybean lipoxygenase (E.C.1.13.11.12) preparation was determined in the presence of various cyclo-oxygenase and lipoxygenase inhibitors.	[1-14c]-arachidonic acid	19-43	linoleate 9S-lipoxygenase-4	Glycine max	169-181
6440614-6	1984	In this new multiple-site model the potent lipoxygenase inhibitors (e.g. acetone phenylhydrazone, phenidone) possess high affinities for both sites, whereas weak inhibitors and certain cyclo-oxygenase inhibitors (e.g. benoxaprofen, phenylbutazone, indomethacin) interact predominantly with the supplementary site on the lipoxygenase but lack affinity for the catalytic site.	acetone phenylhydrazone	73-96	linoleate 9S-lipoxygenase-4	Glycine max	43-55
6440614-6	1984	In this new multiple-site model the potent lipoxygenase inhibitors (e.g. acetone phenylhydrazone, phenidone) possess high affinities for both sites, whereas weak inhibitors and certain cyclo-oxygenase inhibitors (e.g. benoxaprofen, phenylbutazone, indomethacin) interact predominantly with the supplementary site on the lipoxygenase but lack affinity for the catalytic site.	acetone phenylhydrazone	73-96	linoleate 9S-lipoxygenase-4	Glycine max	320-332
6440614-6	1984	In this new multiple-site model the potent lipoxygenase inhibitors (e.g. acetone phenylhydrazone, phenidone) possess high affinities for both sites, whereas weak inhibitors and certain cyclo-oxygenase inhibitors (e.g. benoxaprofen, phenylbutazone, indomethacin) interact predominantly with the supplementary site on the lipoxygenase but lack affinity for the catalytic site.	phenidone	98-107	linoleate 9S-lipoxygenase-4	Glycine max	43-55
6440614-6	1984	In this new multiple-site model the potent lipoxygenase inhibitors (e.g. acetone phenylhydrazone, phenidone) possess high affinities for both sites, whereas weak inhibitors and certain cyclo-oxygenase inhibitors (e.g. benoxaprofen, phenylbutazone, indomethacin) interact predominantly with the supplementary site on the lipoxygenase but lack affinity for the catalytic site.	phenidone	98-107	linoleate 9S-lipoxygenase-4	Glycine max	320-332
6440614-6	1984	In this new multiple-site model the potent lipoxygenase inhibitors (e.g. acetone phenylhydrazone, phenidone) possess high affinities for both sites, whereas weak inhibitors and certain cyclo-oxygenase inhibitors (e.g. benoxaprofen, phenylbutazone, indomethacin) interact predominantly with the supplementary site on the lipoxygenase but lack affinity for the catalytic site.	benoxaprofen	218-230	linoleate 9S-lipoxygenase-4	Glycine max	43-55
6440614-6	1984	In this new multiple-site model the potent lipoxygenase inhibitors (e.g. acetone phenylhydrazone, phenidone) possess high affinities for both sites, whereas weak inhibitors and certain cyclo-oxygenase inhibitors (e.g. benoxaprofen, phenylbutazone, indomethacin) interact predominantly with the supplementary site on the lipoxygenase but lack affinity for the catalytic site.	Phenylbutazone	232-246	linoleate 9S-lipoxygenase-4	Glycine max	43-55
6440614-6	1984	In this new multiple-site model the potent lipoxygenase inhibitors (e.g. acetone phenylhydrazone, phenidone) possess high affinities for both sites, whereas weak inhibitors and certain cyclo-oxygenase inhibitors (e.g. benoxaprofen, phenylbutazone, indomethacin) interact predominantly with the supplementary site on the lipoxygenase but lack affinity for the catalytic site.	Indomethacin	248-260	linoleate 9S-lipoxygenase-4	Glycine max	43-55
6437870-1	1984	The pure lipoxygenase from reticulocytes converts 5,15-di-HETE at 2 degrees C to product(s) showing a characteristic UV spectrum with maxima of strong absorbance at 300 and 316 nm and shoulders at 285 and 350 nm.	5,15-dihydroxy-6,8,11,13-eicosatetraenoic acid	50-62	linoleate 9S-lipoxygenase-4	Glycine max	9-21
6437870-5	1984	The lipoxygenase from soybeans also converts 5,15-di-HETE to these product(s) with a comparable initial rate but different kinetics.	5,15-dihydroxy-6,8,11,13-eicosatetraenoic acid	45-57	linoleate 9S-lipoxygenase-4	Glycine max	4-16
6437870-6	1984	These data suggest that 5,15-di-HETE is converted via a lipoxygenase reaction to 5,6,15-trihydroxy-7,9,11,13-(e,e,c,e)- and/or 5,14,15-trihydroxy-6,8,10,12-(e,c,e,e)-eicosatetraenoic acid, both of which contain a conjugated tetraene system.	5,15-dihydroxy-6,8,11,13-eicosatetraenoic acid	24-36	linoleate 9S-lipoxygenase-4	Glycine max	56-68
6437870-6	1984	These data suggest that 5,15-di-HETE is converted via a lipoxygenase reaction to 5,6,15-trihydroxy-7,9,11,13-(e,e,c,e)- and/or 5,14,15-trihydroxy-6,8,10,12-(e,c,e,e)-eicosatetraenoic acid, both of which contain a conjugated tetraene system.	5,6,15-trihydroxy-7,9,11,13-(e,e,c,e)-	81-119	linoleate 9S-lipoxygenase-4	Glycine max	56-68
6437870-6	1984	These data suggest that 5,15-di-HETE is converted via a lipoxygenase reaction to 5,6,15-trihydroxy-7,9,11,13-(e,e,c,e)- and/or 5,14,15-trihydroxy-6,8,10,12-(e,c,e,e)-eicosatetraenoic acid, both of which contain a conjugated tetraene system.	5,14,15-trihydroxy-6,8,10,12-(e,c,e,e)-eicosatetraenoic acid	127-187	linoleate 9S-lipoxygenase-4	Glycine max	56-68
6437870-6	1984	These data suggest that 5,15-di-HETE is converted via a lipoxygenase reaction to 5,6,15-trihydroxy-7,9,11,13-(e,e,c,e)- and/or 5,14,15-trihydroxy-6,8,10,12-(e,c,e,e)-eicosatetraenoic acid, both of which contain a conjugated tetraene system.	tetraene	224-232	linoleate 9S-lipoxygenase-4	Glycine max	56-68
6433987-0	1984	Pentane formation during the anaerobic reactions of reticulocyte lipoxygenase.	pentane	0-7	linoleate 9S-lipoxygenase-4	Glycine max	65-77
6433987-4	1984	Relative to the lipoxygenase activity with linoleic acid as substrate, soybean lipoxygenase is 4-times as effective in pentane formation as the lipoxygenases from reticulocytes or green pea seeds.	Linoleic Acid	43-56	linoleate 9S-lipoxygenase-4	Glycine max	79-91
6433987-4	1984	Relative to the lipoxygenase activity with linoleic acid as substrate, soybean lipoxygenase is 4-times as effective in pentane formation as the lipoxygenases from reticulocytes or green pea seeds.	pentane	119-126	linoleate 9S-lipoxygenase-4	Glycine max	79-91
6433987-5	1984	Pentane formation by the reticulocyte lipoxygenase is completely inhibited by lipoxygenase inhibitors (5,8,11,14-eicosatetraynoic acid, 3-t-butyl-4-hydroxyanisol) but only partially by radical scavengers which do not influence the oxygenase activity (2,6-di-t-butyl-4-hydroxytoluene).	pentane	0-7	linoleate 9S-lipoxygenase-4	Glycine max	38-50
6433987-5	1984	Pentane formation by the reticulocyte lipoxygenase is completely inhibited by lipoxygenase inhibitors (5,8,11,14-eicosatetraynoic acid, 3-t-butyl-4-hydroxyanisol) but only partially by radical scavengers which do not influence the oxygenase activity (2,6-di-t-butyl-4-hydroxytoluene).	pentane	0-7	linoleate 9S-lipoxygenase-4	Glycine max	78-90
6433987-5	1984	Pentane formation by the reticulocyte lipoxygenase is completely inhibited by lipoxygenase inhibitors (5,8,11,14-eicosatetraynoic acid, 3-t-butyl-4-hydroxyanisol) but only partially by radical scavengers which do not influence the oxygenase activity (2,6-di-t-butyl-4-hydroxytoluene).	5,8,11,14-Eicosatetraynoic Acid	103-134	linoleate 9S-lipoxygenase-4	Glycine max	38-50
6433987-5	1984	Pentane formation by the reticulocyte lipoxygenase is completely inhibited by lipoxygenase inhibitors (5,8,11,14-eicosatetraynoic acid, 3-t-butyl-4-hydroxyanisol) but only partially by radical scavengers which do not influence the oxygenase activity (2,6-di-t-butyl-4-hydroxytoluene).	5,8,11,14-Eicosatetraynoic Acid	103-134	linoleate 9S-lipoxygenase-4	Glycine max	78-90
6433987-5	1984	Pentane formation by the reticulocyte lipoxygenase is completely inhibited by lipoxygenase inhibitors (5,8,11,14-eicosatetraynoic acid, 3-t-butyl-4-hydroxyanisol) but only partially by radical scavengers which do not influence the oxygenase activity (2,6-di-t-butyl-4-hydroxytoluene).	3-t-butyl-4-hydroxyanisol	136-161	linoleate 9S-lipoxygenase-4	Glycine max	38-50
6433987-5	1984	Pentane formation by the reticulocyte lipoxygenase is completely inhibited by lipoxygenase inhibitors (5,8,11,14-eicosatetraynoic acid, 3-t-butyl-4-hydroxyanisol) but only partially by radical scavengers which do not influence the oxygenase activity (2,6-di-t-butyl-4-hydroxytoluene).	3-t-butyl-4-hydroxyanisol	136-161	linoleate 9S-lipoxygenase-4	Glycine max	78-90
6433987-5	1984	Pentane formation by the reticulocyte lipoxygenase is completely inhibited by lipoxygenase inhibitors (5,8,11,14-eicosatetraynoic acid, 3-t-butyl-4-hydroxyanisol) but only partially by radical scavengers which do not influence the oxygenase activity (2,6-di-t-butyl-4-hydroxytoluene).	2,6-di-t-butyl-4-hydroxytoluene	251-282	linoleate 9S-lipoxygenase-4	Glycine max	38-50
6433987-5	1984	Pentane formation by the reticulocyte lipoxygenase is completely inhibited by lipoxygenase inhibitors (5,8,11,14-eicosatetraynoic acid, 3-t-butyl-4-hydroxyanisol) but only partially by radical scavengers which do not influence the oxygenase activity (2,6-di-t-butyl-4-hydroxytoluene).	2,6-di-t-butyl-4-hydroxytoluene	251-282	linoleate 9S-lipoxygenase-4	Glycine max	78-90
6433987-6	1984	From the temperature dependence below 20 degrees C an activation energy of the pentane production by the reticulocyte lipoxygenase of about 28 kJ/mol was calculated, which is somewhat higher than that for the oxygenase activity.	pentane	79-86	linoleate 9S-lipoxygenase-4	Glycine max	118-130
6433987-7	1984	During the anaerobic reaction of both reticulocyte and soybean lipoxygenase C18-oxodienes, C13-oxodienes, linoleic acid dimers and a polar compound proposed to be epoxy-hydroxyoctadecenoic acid are produced in a similar pattern.	c18-oxodienes	76-89	linoleate 9S-lipoxygenase-4	Glycine max	63-75
6433987-7	1984	During the anaerobic reaction of both reticulocyte and soybean lipoxygenase C18-oxodienes, C13-oxodienes, linoleic acid dimers and a polar compound proposed to be epoxy-hydroxyoctadecenoic acid are produced in a similar pattern.	c13-oxodienes	91-104	linoleate 9S-lipoxygenase-4	Glycine max	63-75
6433987-7	1984	During the anaerobic reaction of both reticulocyte and soybean lipoxygenase C18-oxodienes, C13-oxodienes, linoleic acid dimers and a polar compound proposed to be epoxy-hydroxyoctadecenoic acid are produced in a similar pattern.	Linoleic Acid	106-119	linoleate 9S-lipoxygenase-4	Glycine max	63-75
6433987-7	1984	During the anaerobic reaction of both reticulocyte and soybean lipoxygenase C18-oxodienes, C13-oxodienes, linoleic acid dimers and a polar compound proposed to be epoxy-hydroxyoctadecenoic acid are produced in a similar pattern.	epoxy-hydroxyoctadecenoic acid	163-193	linoleate 9S-lipoxygenase-4	Glycine max	63-75
6433987-8	1984	Reticulocyte lipoxygenase produces pentane with submitochondrial particles only under anaerobic conditions after an aerobic preincubation.	pentane	35-42	linoleate 9S-lipoxygenase-4	Glycine max	13-25
6433987-10	1984	Preincubation of the cells with lipoxygenase inhibitors completely abolishes the pentane formation.	pentane	81-88	linoleate 9S-lipoxygenase-4	Glycine max	32-44
16663862-5	1984	On the basis of the sensitivity of the lipoxygenase reaction to both inhibitors (about 90%), the first burst is tentatively assigned to oxy-radicals mobilized upon water uptake by the embryonic axes, and the second phase is tentatively identified as due to lipoxygenase activity.	oxy-radicals	136-148	linoleate 9S-lipoxygenase-4	Glycine max	39-51
16663862-5	1984	On the basis of the sensitivity of the lipoxygenase reaction to both inhibitors (about 90%), the first burst is tentatively assigned to oxy-radicals mobilized upon water uptake by the embryonic axes, and the second phase is tentatively identified as due to lipoxygenase activity.	Water	164-169	linoleate 9S-lipoxygenase-4	Glycine max	39-51
16663862-6	1984	The in vivo lipoxygenase activity of the embryonic axes was estimated by both the fraction of total oxygen uptake that was inhibited by butylated hydroxyanisole and by the fraction of photoemission that was inhibited by butylated hydroxyanisole and by salicylhydroxamic acid.	Butylated Hydroxyanisole	136-160	linoleate 9S-lipoxygenase-4	Glycine max	12-24
16663862-6	1984	The in vivo lipoxygenase activity of the embryonic axes was estimated by both the fraction of total oxygen uptake that was inhibited by butylated hydroxyanisole and by the fraction of photoemission that was inhibited by butylated hydroxyanisole and by salicylhydroxamic acid.	Butylated Hydroxyanisole	220-244	linoleate 9S-lipoxygenase-4	Glycine max	12-24
16663862-6	1984	The in vivo lipoxygenase activity of the embryonic axes was estimated by both the fraction of total oxygen uptake that was inhibited by butylated hydroxyanisole and by the fraction of photoemission that was inhibited by butylated hydroxyanisole and by salicylhydroxamic acid.	salicylhydroxamic acid	252-274	linoleate 9S-lipoxygenase-4	Glycine max	12-24
16663862-8	1984	The measured chemiluminescence per O(2) uptake ratio (the experimental quantum yield) for the lipoxygenase reaction (3.3 x 10(-14) counts per O(2) molecule) was used to estimate the O(2) uptake due to lipoxygenase activity from the photoemission of the embryonic axes after 30 hours of imbibition.	Oxygen	35-39	linoleate 9S-lipoxygenase-4	Glycine max	94-106
16663862-8	1984	The measured chemiluminescence per O(2) uptake ratio (the experimental quantum yield) for the lipoxygenase reaction (3.3 x 10(-14) counts per O(2) molecule) was used to estimate the O(2) uptake due to lipoxygenase activity from the photoemission of the embryonic axes after 30 hours of imbibition.	Oxygen	35-39	linoleate 9S-lipoxygenase-4	Glycine max	201-213
16663862-8	1984	The measured chemiluminescence per O(2) uptake ratio (the experimental quantum yield) for the lipoxygenase reaction (3.3 x 10(-14) counts per O(2) molecule) was used to estimate the O(2) uptake due to lipoxygenase activity from the photoemission of the embryonic axes after 30 hours of imbibition.	Oxygen	142-146	linoleate 9S-lipoxygenase-4	Glycine max	94-106
16663862-8	1984	The measured chemiluminescence per O(2) uptake ratio (the experimental quantum yield) for the lipoxygenase reaction (3.3 x 10(-14) counts per O(2) molecule) was used to estimate the O(2) uptake due to lipoxygenase activity from the photoemission of the embryonic axes after 30 hours of imbibition.	Oxygen	142-146	linoleate 9S-lipoxygenase-4	Glycine max	201-213
6442774-2	1984	Albumin inhibited oxygen consumption by soybean lipoxygenase.	Oxygen	18-24	linoleate 9S-lipoxygenase-4	Glycine max	48-60
6083770-9	1984	These oxygen species function as oxidizing agents for AA metabolism and amplify the production of hydroxyl radical along the lipoxygenase (and possibly cyclooxygenase) pathway(s).	Oxygen	6-12	linoleate 9S-lipoxygenase-4	Glycine max	125-137
6083770-9	1984	These oxygen species function as oxidizing agents for AA metabolism and amplify the production of hydroxyl radical along the lipoxygenase (and possibly cyclooxygenase) pathway(s).	Hydroxyl Radical	98-114	linoleate 9S-lipoxygenase-4	Glycine max	125-137
3936118-0	1985	Inhibition of soybean lipoxygenase by SKF 525-A and metyrapone.	Metyrapone	52-62	linoleate 9S-lipoxygenase-4	Glycine max	22-34
3936118-1	1985	To determine whether agents which inhibit cytochrome P-450 enzymes also inhibit lipoxygenase, the effects of metyrapone and SKF 525-A were assessed on soybean lipoxygenase using a spectrophotometric technique which allows for measurement of both the rate and magnitude of product formation.	Proadifen	124-133	linoleate 9S-lipoxygenase-4	Glycine max	159-171
6431500-0	1984	Iothalamate stimulates hydroperoxide formation by soybean lipoxygenase.	Iothalamic Acid	0-11	linoleate 9S-lipoxygenase-4	Glycine max	58-70
6431500-0	1984	Iothalamate stimulates hydroperoxide formation by soybean lipoxygenase.	Hydrogen Peroxide	23-36	linoleate 9S-lipoxygenase-4	Glycine max	58-70
6431500-1	1984	Sodium iothalamate produced a dose dependent increase in basal oxygen consumption when soybean lipoxygenase was incubated with arachidonic acid in 0.1M borate buffer pH 9.0.	Iothalamic Acid	0-18	linoleate 9S-lipoxygenase-4	Glycine max	95-107
6431500-1	1984	Sodium iothalamate produced a dose dependent increase in basal oxygen consumption when soybean lipoxygenase was incubated with arachidonic acid in 0.1M borate buffer pH 9.0.	Oxygen	63-69	linoleate 9S-lipoxygenase-4	Glycine max	95-107
6431500-1	1984	Sodium iothalamate produced a dose dependent increase in basal oxygen consumption when soybean lipoxygenase was incubated with arachidonic acid in 0.1M borate buffer pH 9.0.	Arachidonic Acid	127-143	linoleate 9S-lipoxygenase-4	Glycine max	95-107
6431500-1	1984	Sodium iothalamate produced a dose dependent increase in basal oxygen consumption when soybean lipoxygenase was incubated with arachidonic acid in 0.1M borate buffer pH 9.0.	Borates	152-158	linoleate 9S-lipoxygenase-4	Glycine max	95-107
6431500-4	1984	The increase in 1500H arachidonate formation could be blocked by mannitol which is an inhibitor of the lipoxygenase enzyme.	1500h arachidonate	16-34	linoleate 9S-lipoxygenase-4	Glycine max	103-115
6431500-4	1984	The increase in 1500H arachidonate formation could be blocked by mannitol which is an inhibitor of the lipoxygenase enzyme.	Mannitol	65-73	linoleate 9S-lipoxygenase-4	Glycine max	103-115
6427320-0	1984	Determination of cis,cis-methylene interrupted polyunsaturated fatty acids in aqueous solutions by lipoxygenase chemiluminescence.	cis,cis-methylene interrupted polyunsaturated fatty acids	17-74	linoleate 9S-lipoxygenase-4	Glycine max	99-111
6427320-1	1984	The chemiluminescent reaction of luminol during lipoxygenase-catalyzed oxygenations was studied with the purpose of developing a specific luminometric assay for cis,cis-1,4-pentadiene fatty acids directly in aqueous solutions.	Luminol	33-40	linoleate 9S-lipoxygenase-4	Glycine max	48-60
6427320-1	1984	The chemiluminescent reaction of luminol during lipoxygenase-catalyzed oxygenations was studied with the purpose of developing a specific luminometric assay for cis,cis-1,4-pentadiene fatty acids directly in aqueous solutions.	cis,cis-1,4-pentadiene fatty acids	161-195	linoleate 9S-lipoxygenase-4	Glycine max	48-60
6427320-2	1984	The addition of picomole levels of either linoleic or arachidonic acids to reaction systems containing 0.04 mM luminol and 40 micrograms/ml of purified soybean lipoxygenase-1 gave light emission curves with a single sharp maximum.	Linoleic Acid	42-50	linoleate 9S-lipoxygenase-4	Glycine max	160-172
6427320-2	1984	The addition of picomole levels of either linoleic or arachidonic acids to reaction systems containing 0.04 mM luminol and 40 micrograms/ml of purified soybean lipoxygenase-1 gave light emission curves with a single sharp maximum.	Arachidonic Acids	54-71	linoleate 9S-lipoxygenase-4	Glycine max	160-172
6427320-2	1984	The addition of picomole levels of either linoleic or arachidonic acids to reaction systems containing 0.04 mM luminol and 40 micrograms/ml of purified soybean lipoxygenase-1 gave light emission curves with a single sharp maximum.	Luminol	111-118	linoleate 9S-lipoxygenase-4	Glycine max	160-172
6440550-2	1984	5,8,11-eicosatriynoic acid (ETrYA) is a powerful inactivator only for reticulocyte lipoxygenase.	5,8,11-eicosatriynoic acid	0-26	linoleate 9S-lipoxygenase-4	Glycine max	83-95
6421582-1	1984	The inactivation of soybean lipoxygenase by 5,8,11,14-eicosatetraynoic acid was studied in detail.	5,8,11,14-Eicosatetraynoic Acid	44-75	linoleate 9S-lipoxygenase-4	Glycine max	28-40
6440550-2	1984	5,8,11-eicosatriynoic acid (ETrYA) is a powerful inactivator only for reticulocyte lipoxygenase.	5,8,11-eicosatriynoic acid	28-33	linoleate 9S-lipoxygenase-4	Glycine max	83-95
6440550-3	1984	Several types of experimental evidence indicate that the acetylenic fatty acids act as suicidal substrates which are converted during the lipoxygenase reaction probably to allene hydroperoxides.	acetylenic fatty acids	57-79	linoleate 9S-lipoxygenase-4	Glycine max	138-150
6440550-3	1984	Several types of experimental evidence indicate that the acetylenic fatty acids act as suicidal substrates which are converted during the lipoxygenase reaction probably to allene hydroperoxides.	allene hydroperoxides	172-193	linoleate 9S-lipoxygenase-4	Glycine max	138-150
6421635-0	1984	New aspects of the inhibition of soybean lipoxygenase by alpha-tocopherol.	alpha-Tocopherol	57-73	linoleate 9S-lipoxygenase-4	Glycine max	41-53
6428914-0	1984	Soybean lipoxygenase inhibition: studies with the sulphasalazine metabolites N-acetylaminosalicylic acid, 5-aminosalicylic acid and sulphapyridine.	Sulfasalazine	50-64	linoleate 9S-lipoxygenase-4	Glycine max	8-20
6428914-2	1984	In an extension of a recent study which showed that therapeutically active compounds, such as sulphasalazine and its colonic metabolite 5-aminosalicylic acid were soybean lipoxygenase inhibitors, it has now been shown that N-acetylaminosalicylic acid, the principal metabolite of 5-aminosalicylic acid, also inhibits soybean lipoxygenase in a dose dependent and noncompetitive manner (Ki 3.0 X 10(-8) M, IC50 250 microM).	Sulfasalazine	94-108	linoleate 9S-lipoxygenase-4	Glycine max	171-183
6428914-2	1984	In an extension of a recent study which showed that therapeutically active compounds, such as sulphasalazine and its colonic metabolite 5-aminosalicylic acid were soybean lipoxygenase inhibitors, it has now been shown that N-acetylaminosalicylic acid, the principal metabolite of 5-aminosalicylic acid, also inhibits soybean lipoxygenase in a dose dependent and noncompetitive manner (Ki 3.0 X 10(-8) M, IC50 250 microM).	Sulfasalazine	94-108	linoleate 9S-lipoxygenase-4	Glycine max	325-337
6428914-2	1984	In an extension of a recent study which showed that therapeutically active compounds, such as sulphasalazine and its colonic metabolite 5-aminosalicylic acid were soybean lipoxygenase inhibitors, it has now been shown that N-acetylaminosalicylic acid, the principal metabolite of 5-aminosalicylic acid, also inhibits soybean lipoxygenase in a dose dependent and noncompetitive manner (Ki 3.0 X 10(-8) M, IC50 250 microM).	Mesalamine	136-157	linoleate 9S-lipoxygenase-4	Glycine max	171-183
6428914-2	1984	In an extension of a recent study which showed that therapeutically active compounds, such as sulphasalazine and its colonic metabolite 5-aminosalicylic acid were soybean lipoxygenase inhibitors, it has now been shown that N-acetylaminosalicylic acid, the principal metabolite of 5-aminosalicylic acid, also inhibits soybean lipoxygenase in a dose dependent and noncompetitive manner (Ki 3.0 X 10(-8) M, IC50 250 microM).	Mesalamine	136-157	linoleate 9S-lipoxygenase-4	Glycine max	325-337
6421635-2	1984	The formation of alpha-tocopherol--lipoxygenase complex was elucidated using immobilized affinity purified soybean lipoxygenase and [D-3H]alpha-tocopherol.	Tocopherols	23-33	linoleate 9S-lipoxygenase-4	Glycine max	35-47
6421635-2	1984	The formation of alpha-tocopherol--lipoxygenase complex was elucidated using immobilized affinity purified soybean lipoxygenase and [D-3H]alpha-tocopherol.	Tocopherols	23-33	linoleate 9S-lipoxygenase-4	Glycine max	115-127
6421635-2	1984	The formation of alpha-tocopherol--lipoxygenase complex was elucidated using immobilized affinity purified soybean lipoxygenase and [D-3H]alpha-tocopherol.	[d-3h]alpha-tocopherol	132-154	linoleate 9S-lipoxygenase-4	Glycine max	35-47
6421635-4	1984	Iodoacetate modified immobilized lipoxygenase did not form the complex with alpha-tocopherol.	Iodoacetates	0-11	linoleate 9S-lipoxygenase-4	Glycine max	33-45
6421635-5	1984	Lipoxygenase attached to an aminoethyl linoleyl Sepharose column was eluted by alpha-tocopherol.	aminoethyl linoleyl sepharose	28-57	linoleate 9S-lipoxygenase-4	Glycine max	0-12
6421635-5	1984	Lipoxygenase attached to an aminoethyl linoleyl Sepharose column was eluted by alpha-tocopherol.	alpha-Tocopherol	79-95	linoleate 9S-lipoxygenase-4	Glycine max	0-12
6421635-6	1984	DL-alpha-Tocopherol acetate at a concentration of 3 X 10(-3) M inhibited 80% of linoleate oxidation by soybean lipoxygenase.	DL-alpha-Tocopherol acetate	0-27	linoleate 9S-lipoxygenase-4	Glycine max	111-123
6421635-6	1984	DL-alpha-Tocopherol acetate at a concentration of 3 X 10(-3) M inhibited 80% of linoleate oxidation by soybean lipoxygenase.	Linoleic Acid	80-89	linoleate 9S-lipoxygenase-4	Glycine max	111-123
6421635-7	1984	The lipoxygenase--alpha-tocopherol complex did not give the usual soybean lipoxygenase antigenic pattern in immunodiffusion.	alpha-Tocopherol	18-34	linoleate 9S-lipoxygenase-4	Glycine max	4-16
6421635-8	1984	Digestion of the [3H]alpha-tocopherol--lipoxygenase complex with proteolytic enzymes showed that most of the radioactivity is incorporated into one peptide.	Tritium	18-20	linoleate 9S-lipoxygenase-4	Glycine max	39-51
6413205-2	1983	Lipoxygenase (EC 1.13.11.12) was enriched 20-fold from soybean acetone powder.	Acetone	63-70	linoleate 9S-lipoxygenase-4	Glycine max	0-12
6413205-3	1983	Linoleic acid was peroxidized with lipoxygenase and then used as a substrate in the glutathione peroxidase reaction.	Linoleic Acid	0-13	linoleate 9S-lipoxygenase-4	Glycine max	35-47
6316436-3	1983	The radiolabeled lipoxygenase metabolites were isolated by a combination of organic extraction, silicic acid chromatography and reverse-phase high pressure liquid chromatography (RP-HPLC).	Silicic Acid	96-108	linoleate 9S-lipoxygenase-4	Glycine max	17-29
6412709-7	1983	Two members of this new family of fatty acids (5 and 6) were found to inhibit the catalysis of the oxygenation of linoleic acid by soybean type-1 lipoxygenase.	Fatty Acids	34-45	linoleate 9S-lipoxygenase-4	Glycine max	146-158
6412709-7	1983	Two members of this new family of fatty acids (5 and 6) were found to inhibit the catalysis of the oxygenation of linoleic acid by soybean type-1 lipoxygenase.	Linoleic Acid	114-127	linoleate 9S-lipoxygenase-4	Glycine max	146-158
6414114-0	1983	Styrene oxidation to styrene oxide coupled with arachidonic acid oxidation by soybean lipoxygenase.	Arachidonic Acid	48-64	linoleate 9S-lipoxygenase-4	Glycine max	86-98
6414114-1	1983	Styrene was co-oxidated to styrene oxide during soybean lipoxygenase catalyzed formation of arachidonic acid lipid peroxides.	Styrene	0-7	linoleate 9S-lipoxygenase-4	Glycine max	56-68
6414114-1	1983	Styrene was co-oxidated to styrene oxide during soybean lipoxygenase catalyzed formation of arachidonic acid lipid peroxides.	styrene oxide	27-40	linoleate 9S-lipoxygenase-4	Glycine max	56-68
6414114-1	1983	Styrene was co-oxidated to styrene oxide during soybean lipoxygenase catalyzed formation of arachidonic acid lipid peroxides.	arachidonic acid lipid peroxides	92-124	linoleate 9S-lipoxygenase-4	Glycine max	56-68
6418158-3	1983	Haemoglobin augments also the lipoxygenase-induced loss of acid-labile sulphur in ETP not related to respiratory inhibition.	Ethionamide	82-85	linoleate 9S-lipoxygenase-4	Glycine max	30-42
6199312-2	1984	15-Hydroxyeicosatetraenoic acid (15-HETE) was prepared by soybean lipoxygenase-mediated oxygenation of arachidonic acid to 15-hydroperoxyeicosatetraenoic acid (15-HETE) and subsequent reduction by NaBH4.	15-hydroperoxyeicosatetraenoic acid	123-158	linoleate 9S-lipoxygenase-4	Glycine max	66-78
6199312-2	1984	15-Hydroxyeicosatetraenoic acid (15-HETE) was prepared by soybean lipoxygenase-mediated oxygenation of arachidonic acid to 15-hydroperoxyeicosatetraenoic acid (15-HETE) and subsequent reduction by NaBH4.	15-Hete	160-167	linoleate 9S-lipoxygenase-4	Glycine max	66-78
6199312-2	1984	15-Hydroxyeicosatetraenoic acid (15-HETE) was prepared by soybean lipoxygenase-mediated oxygenation of arachidonic acid to 15-hydroperoxyeicosatetraenoic acid (15-HETE) and subsequent reduction by NaBH4.	sodium borohydride	197-202	linoleate 9S-lipoxygenase-4	Glycine max	66-78
6411134-3	1983	The rate of arachidonate oxidation by soybean lipoxygenase in the presence of these lipoproteins was either unaffected or decreased.	Arachidonic Acid	12-24	linoleate 9S-lipoxygenase-4	Glycine max	46-58
6408711-2	1983	It was found that the best inhibitors of lipoxygenase were naproxen, BW 755C, indomethacin and isoxicam.	Naproxen	59-67	linoleate 9S-lipoxygenase-4	Glycine max	41-53
6408711-2	1983	It was found that the best inhibitors of lipoxygenase were naproxen, BW 755C, indomethacin and isoxicam.	4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine	69-76	linoleate 9S-lipoxygenase-4	Glycine max	41-53
6408711-2	1983	It was found that the best inhibitors of lipoxygenase were naproxen, BW 755C, indomethacin and isoxicam.	Indomethacin	78-90	linoleate 9S-lipoxygenase-4	Glycine max	41-53
6408711-2	1983	It was found that the best inhibitors of lipoxygenase were naproxen, BW 755C, indomethacin and isoxicam.	isoxicam	95-103	linoleate 9S-lipoxygenase-4	Glycine max	41-53
6199312-2	1984	15-Hydroxyeicosatetraenoic acid (15-HETE) was prepared by soybean lipoxygenase-mediated oxygenation of arachidonic acid to 15-hydroperoxyeicosatetraenoic acid (15-HETE) and subsequent reduction by NaBH4.	Eicosatetraenoic acid, 15-hydroxy-	0-31	linoleate 9S-lipoxygenase-4	Glycine max	66-78
6199312-2	1984	15-Hydroxyeicosatetraenoic acid (15-HETE) was prepared by soybean lipoxygenase-mediated oxygenation of arachidonic acid to 15-hydroperoxyeicosatetraenoic acid (15-HETE) and subsequent reduction by NaBH4.	15-Hete	33-40	linoleate 9S-lipoxygenase-4	Glycine max	66-78
6199312-2	1984	15-Hydroxyeicosatetraenoic acid (15-HETE) was prepared by soybean lipoxygenase-mediated oxygenation of arachidonic acid to 15-hydroperoxyeicosatetraenoic acid (15-HETE) and subsequent reduction by NaBH4.	Arachidonic Acid	103-119	linoleate 9S-lipoxygenase-4	Glycine max	66-78
6303533-1	1983	Electron spin resonance (ESR) spectra have been recorded for 5-doxylstearate (I) and 16-doxylstearate (II) in the presence of bacterial luciferase and soybean lipoxygenase.	5-doxylstearic acid	61-76	linoleate 9S-lipoxygenase-4	Glycine max	159-171
6419240-2	1983	A variety of prostaglandin synthetase inhibitors are cooxygenated during arachidonic acid peroxidation catalyzed by rat renal medulla prostaglandin synthetase or soybean lipoxygenase.	Prostaglandins	13-26	linoleate 9S-lipoxygenase-4	Glycine max	170-182
6419240-2	1983	A variety of prostaglandin synthetase inhibitors are cooxygenated during arachidonic acid peroxidation catalyzed by rat renal medulla prostaglandin synthetase or soybean lipoxygenase.	Arachidonic Acid	73-89	linoleate 9S-lipoxygenase-4	Glycine max	170-182
6814209-2	1982	We found that besides this compound a variety of hydrazones derived from other ketones and hydrazines exhibited similar or more interesting inhibition patterns both against soybean lipoxygenase and rat renal prostaglandin synthetase.	Ketones	79-86	linoleate 9S-lipoxygenase-4	Glycine max	181-193
16662797-0	1983	Structural Features Required for Inhibition of Soybean Lipoxygenase-2 by Propyl Gallate : Evidence that Lipoxygenase Activity Is Distinct from the Alternative Pathway.	Propyl Gallate	73-87	linoleate 9S-lipoxygenase-4	Glycine max	104-116
16662797-4	1983	The results indicate that the o-dihydroxy and not the ester function of propyl gallate is essential for inhibition of lipoxygenase.	Propyl Gallate	72-86	linoleate 9S-lipoxygenase-4	Glycine max	118-130
16662797-6	1983	Among those compounds possessing an o-dihydroxy function, the K(i)" for inhibition of lipoxygenase is directly related to the lipophilicity of the inhibitor as measured by the octanol-water partition coefficient.	Octanols	176-183	linoleate 9S-lipoxygenase-4	Glycine max	86-98
16662797-6	1983	Among those compounds possessing an o-dihydroxy function, the K(i)" for inhibition of lipoxygenase is directly related to the lipophilicity of the inhibitor as measured by the octanol-water partition coefficient.	Water	184-189	linoleate 9S-lipoxygenase-4	Glycine max	86-98
16662797-7	1983	The structural features of propyl gallate necessary for inhibition of lipoxygenase were found to differ from those required for inhibition of the plant mitochondrial alternative pathway.	Propyl Gallate	27-41	linoleate 9S-lipoxygenase-4	Glycine max	70-82
6817003-4	1982	A 5S,15S-dihydroxy-6,8,11,13(E,Z,Z,E)-eicosatetraenoic acid was obtained from incubations of 5S-hydroxy-6,8,11,14(E,Z,Z,Z)-eicosatetraenoic acid with the soybean lipoxygenase and reduction with stannous chloride, and was used as reference compound.	5s,15s-dihydroxy-6,8,11,13(e,z,z,e)-eicosatetraenoic acid	2-59	linoleate 9S-lipoxygenase-4	Glycine max	162-174
6817003-4	1982	A 5S,15S-dihydroxy-6,8,11,13(E,Z,Z,E)-eicosatetraenoic acid was obtained from incubations of 5S-hydroxy-6,8,11,14(E,Z,Z,Z)-eicosatetraenoic acid with the soybean lipoxygenase and reduction with stannous chloride, and was used as reference compound.	5s-hydroxy-6,8,11,14(e,z,z,z)-eicosatetraenoic acid	93-144	linoleate 9S-lipoxygenase-4	Glycine max	162-174
16662797-0	1983	Structural Features Required for Inhibition of Soybean Lipoxygenase-2 by Propyl Gallate : Evidence that Lipoxygenase Activity Is Distinct from the Alternative Pathway.	Propyl Gallate	73-87	linoleate 9S-lipoxygenase-4	Glycine max	55-67
27519438-2	1982	Separation of Ca(2+)-stimulated lipoxygenase from lipoxygenase active in the absence of Ca(2+) (lipoxygenase-1) was readily obtained using a DEAE-cellulose column.	DEAE-Cellulose	141-155	linoleate 9S-lipoxygenase-4	Glycine max	32-44
27519438-2	1982	Separation of Ca(2+)-stimulated lipoxygenase from lipoxygenase active in the absence of Ca(2+) (lipoxygenase-1) was readily obtained using a DEAE-cellulose column.	DEAE-Cellulose	141-155	linoleate 9S-lipoxygenase-4	Glycine max	50-62
27519438-5	1982	Ca(2+)-stimulated lipoxygenase bound to DAAE-cellulose required the use of a NaCl gradient for elution.	daae-cellulose	40-54	linoleate 9S-lipoxygenase-4	Glycine max	18-30
27519438-5	1982	Ca(2+)-stimulated lipoxygenase bound to DAAE-cellulose required the use of a NaCl gradient for elution.	Sodium Chloride	77-81	linoleate 9S-lipoxygenase-4	Glycine max	18-30
27519438-6	1982	Ca(2+)-stimulated lipoxygenase showed an apparent isoelectric point at pH 5.90 and optimum activity at pH 7.5 and at 1.1 mM calcium.	Calcium	124-131	linoleate 9S-lipoxygenase-4	Glycine max	18-30
6814209-1	1982	Acetone phenylhydrazone has recently been discovered as a predominant inhibitor of arachidonic acid lipoxygenase in platelets [1].	acetone phenylhydrazone	0-23	linoleate 9S-lipoxygenase-4	Glycine max	100-112
6814209-2	1982	We found that besides this compound a variety of hydrazones derived from other ketones and hydrazines exhibited similar or more interesting inhibition patterns both against soybean lipoxygenase and rat renal prostaglandin synthetase.	Hydrazones	49-59	linoleate 9S-lipoxygenase-4	Glycine max	181-193
6814209-2	1982	We found that besides this compound a variety of hydrazones derived from other ketones and hydrazines exhibited similar or more interesting inhibition patterns both against soybean lipoxygenase and rat renal prostaglandin synthetase.	Hydrazines	91-101	linoleate 9S-lipoxygenase-4	Glycine max	181-193
16661801-0	1981	Use of Tetraethylthiuram Disulfide to Discriminate between Alternative Respiration and Lipoxygenase.	Disulfiram	7-34	linoleate 9S-lipoxygenase-4	Glycine max	87-99
6788761-0	1981	Deuterium nuclear magnetic resonance study of the interaction of substrates and inhibitors with soybean lipoxygenase.	Deuterium	0-9	linoleate 9S-lipoxygenase-4	Glycine max	104-116
6788761-4	1981	Kinetic measurements established Ki = 1.5 X 10(-3) M for dodecanoic acid (lauric acid) inhibition of lipoxygenase when the substrate is linoleic acid (Km = 2.6 X 10(-5) M).	lauric acid	57-72	linoleate 9S-lipoxygenase-4	Glycine max	101-113
6788761-4	1981	Kinetic measurements established Ki = 1.5 X 10(-3) M for dodecanoic acid (lauric acid) inhibition of lipoxygenase when the substrate is linoleic acid (Km = 2.6 X 10(-5) M).	lauric acid	74-85	linoleate 9S-lipoxygenase-4	Glycine max	101-113
6788761-4	1981	Kinetic measurements established Ki = 1.5 X 10(-3) M for dodecanoic acid (lauric acid) inhibition of lipoxygenase when the substrate is linoleic acid (Km = 2.6 X 10(-5) M).	Linoleic Acid	136-149	linoleate 9S-lipoxygenase-4	Glycine max	101-113
16661801-4	1981	These mitochondria also possessed lipoxygenase activity, as determined by O(2) uptake in the presence of 0.8 millimolar linoleic acid.	o(2)	74-78	linoleate 9S-lipoxygenase-4	Glycine max	34-46
16661801-4	1981	These mitochondria also possessed lipoxygenase activity, as determined by O(2) uptake in the presence of 0.8 millimolar linoleic acid.	Linoleic Acid	120-133	linoleate 9S-lipoxygenase-4	Glycine max	34-46
16661801-7	1981	Use of tetraethylthiuram disulfide allows discrimination between alternative respiration and lipoxygenase activity in mitochondria.	Disulfiram	7-34	linoleate 9S-lipoxygenase-4	Glycine max	93-105
6783111-12	1981	A series of phenyl hydrazone inhibitors of various structural types were discovered to be potent inhibitors of the human platelet lipoxygenase.	phenylhydrazone	12-28	linoleate 9S-lipoxygenase-4	Glycine max	130-142
6776993-1	1980	The absolute configurations of a number of unsaturated hydroperoxy fatty acids obtained by lipoxygenase catalysis were investigated by capillary gas-liquid chromatography after proper derivatization.	unsaturated hydroperoxy fatty acids	43-78	linoleate 9S-lipoxygenase-4	Glycine max	91-103
6779301-4	1980	Epinephrine was assessed for its effects on the lag phase in activation of soybean lipoxygenase and was found to cause a similar reduction of the lag phase of this related enzyme.	Epinephrine	0-11	linoleate 9S-lipoxygenase-4	Glycine max	83-95
6779301-5	1980	These findings support the concept that reduction of Fe3+-heme to Fe2+-heme is critical to activation of both the prostaglandin endoperoxide synthetase and soybean lipoxygenase enzymes, and that mechanisms involved in regulation of the valence of iron are important for regulating enzyme activity.	fe3+-heme	53-62	linoleate 9S-lipoxygenase-4	Glycine max	164-176
6779301-5	1980	These findings support the concept that reduction of Fe3+-heme to Fe2+-heme is critical to activation of both the prostaglandin endoperoxide synthetase and soybean lipoxygenase enzymes, and that mechanisms involved in regulation of the valence of iron are important for regulating enzyme activity.	fe2+-heme	66-75	linoleate 9S-lipoxygenase-4	Glycine max	164-176
6109281-5	1980	SRS-GSH, SRS-Cys-Gly, and SRS-Cys may be readily distinguished from each other by means of their bioactivities, antagonism by FPL 55712, and relative susceptibilities to the actions of soybean lipoxygenase, microsome-bound leucine aminopeptidase, and gamma-glutamyl transpeptidase.	srs-cys	26-33	linoleate 9S-lipoxygenase-4	Glycine max	193-205
6776357-0	1980	Oxidation of 3-oxygenated delta 4 and delta 5 - C27 steroids by soybean lipoxygenase and rat liver microsomes.	Steroids	52-60	linoleate 9S-lipoxygenase-4	Glycine max	72-84
6776357-1	1980	The formation of dioxygenated metabolites of cholesterol, epicholesterol (5-cholesten-3 alpha-ol) 4-cholesten-3 beta-ol, 4-cholesten-3 alpha-one and 4-stigmasten-3-one was studied after incubations with soybean lipoxygenase and linoleic acid.	5-Cholesten-3-alpha-ol	74-96	linoleate 9S-lipoxygenase-4	Glycine max	211-223
6776357-9	1980	With iron-supplemented microsomes from rat liver, the compounds formed were qualitatively and quantitatively the same as with soybean lipoxygenase, whereas with 18,000 X g rat liver supernatant fractions the yields of all products formed--except 7 alpha-hydroxycholesterol and 6 beta-hydroxy-4-cholesten-3-one--were markedly decreased.	Iron	5-9	linoleate 9S-lipoxygenase-4	Glycine max	134-146
6776357-10	1980	The results indicate the presence of a rat liver microsomal 6 beta-hydroxylase which can use 4-cholesten-3-one as a substrate and extend previous findings of similarities between soybean lipoxygenase and a nonspecific lipoxygenase in rat liver microsomes.	cholest-4-en-3-one	93-110	linoleate 9S-lipoxygenase-4	Glycine max	187-199
6776357-10	1980	The results indicate the presence of a rat liver microsomal 6 beta-hydroxylase which can use 4-cholesten-3-one as a substrate and extend previous findings of similarities between soybean lipoxygenase and a nonspecific lipoxygenase in rat liver microsomes.	cholest-4-en-3-one	93-110	linoleate 9S-lipoxygenase-4	Glycine max	218-230
6250632-2	1980	The zero-field splitting constants (D) of the different components building up the high-spin Fe(III) EPR spectrum of lipoxygenase from soybeans were determined by two methods: (1) temperature dependence studies using the low-spin Fe(III) signal of cytochrome c at g 3 for accurate measuring of the temperature in the sample; (2) by establishing g-shift upon increasing the microwave frequency.	ferric sulfate	93-100	linoleate 9S-lipoxygenase-4	Glycine max	117-129
6250632-2	1980	The zero-field splitting constants (D) of the different components building up the high-spin Fe(III) EPR spectrum of lipoxygenase from soybeans were determined by two methods: (1) temperature dependence studies using the low-spin Fe(III) signal of cytochrome c at g 3 for accurate measuring of the temperature in the sample; (2) by establishing g-shift upon increasing the microwave frequency.	ferric sulfate	230-237	linoleate 9S-lipoxygenase-4	Glycine max	117-129
119581-1	1979	Several 2,5-disubstituted furans, which are known to react with peroxyacids, singlet oxygen and other active forms of oxygen were tested as potential inhibitors, co-oxidants, or substrates for soybean lipoxygenase.	2,5-disubstituted	8-25	linoleate 9S-lipoxygenase-4	Glycine max	201-213
6767147-1	1980	Incubation of linoleic acid with partially purified lipoxygenase from rice germ yielded a ratio of 9- to 13-hydroperoxides of linoleic acid of 97:3 as measured by high performance liquid chromatography.	Linoleic Acid	14-27	linoleate 9S-lipoxygenase-4	Glycine max	52-64
6767147-1	1980	Incubation of linoleic acid with partially purified lipoxygenase from rice germ yielded a ratio of 9- to 13-hydroperoxides of linoleic acid of 97:3 as measured by high performance liquid chromatography.	9- to 13-hydroperoxides	99-122	linoleate 9S-lipoxygenase-4	Glycine max	52-64
6767147-1	1980	Incubation of linoleic acid with partially purified lipoxygenase from rice germ yielded a ratio of 9- to 13-hydroperoxides of linoleic acid of 97:3 as measured by high performance liquid chromatography.	Linoleic Acid	126-139	linoleate 9S-lipoxygenase-4	Glycine max	52-64
117839-0	1979	Co-oxidation of carotenes requires one soybean lipoxygenase isoenzyme.	Carotenoids	16-25	linoleate 9S-lipoxygenase-4	Glycine max	47-59
117839-1	1979	The type II lipoxygenase (optimum pH 6.5) from soybeans was purified and separated into two fractions either by chromatography on DEAE-Sephadex or by isoelectric focusing.	DEAE-Dextran	130-143	linoleate 9S-lipoxygenase-4	Glycine max	12-24
117839-3	1979	Oxygenation of linoleic acid and co-oxidation of canthaxanthine by type II lipoxygenase is stimulated by 13-hydroperoxy-cis-9,trans-11-octadecadienoic acid but not by 13-hydroxy-cis-9,trans-11-octadecadienoic acid or 9-hydroperoxy-trans-10,cis-12-octadecadienoic acid.	Linoleic Acid	15-28	linoleate 9S-lipoxygenase-4	Glycine max	75-87
117839-3	1979	Oxygenation of linoleic acid and co-oxidation of canthaxanthine by type II lipoxygenase is stimulated by 13-hydroperoxy-cis-9,trans-11-octadecadienoic acid but not by 13-hydroxy-cis-9,trans-11-octadecadienoic acid or 9-hydroperoxy-trans-10,cis-12-octadecadienoic acid.	Canthaxanthin	49-63	linoleate 9S-lipoxygenase-4	Glycine max	75-87
117839-3	1979	Oxygenation of linoleic acid and co-oxidation of canthaxanthine by type II lipoxygenase is stimulated by 13-hydroperoxy-cis-9,trans-11-octadecadienoic acid but not by 13-hydroxy-cis-9,trans-11-octadecadienoic acid or 9-hydroperoxy-trans-10,cis-12-octadecadienoic acid.	13-hydroperoxy-cis-9,trans-11-octadecadienoic acid	105-155	linoleate 9S-lipoxygenase-4	Glycine max	75-87
117839-3	1979	Oxygenation of linoleic acid and co-oxidation of canthaxanthine by type II lipoxygenase is stimulated by 13-hydroperoxy-cis-9,trans-11-octadecadienoic acid but not by 13-hydroxy-cis-9,trans-11-octadecadienoic acid or 9-hydroperoxy-trans-10,cis-12-octadecadienoic acid.	Coriolic acid	167-213	linoleate 9S-lipoxygenase-4	Glycine max	75-87
117839-3	1979	Oxygenation of linoleic acid and co-oxidation of canthaxanthine by type II lipoxygenase is stimulated by 13-hydroperoxy-cis-9,trans-11-octadecadienoic acid but not by 13-hydroxy-cis-9,trans-11-octadecadienoic acid or 9-hydroperoxy-trans-10,cis-12-octadecadienoic acid.	9-hydroperoxy-trans-10,cis-12-octadecadienoic acid	217-267	linoleate 9S-lipoxygenase-4	Glycine max	75-87
119581-2	1979	The furan, 10,13-epoxy-octadeca-10,12-dienoic acid, methyl ester (IV) was converted by lipoxygenase or singlet oxygen or peroxyacid to the acyclic product, methyl 10,13-dioxo-octadec-11-enoate.	methyl 10,13-dioxo-octadec-11-enoate	156-192	linoleate 9S-lipoxygenase-4	Glycine max	87-99
119581-3	1979	Apparently furan IV is able to interact with an active site of lipoxygenase (Km = 220 microM).	furan	11-16	linoleate 9S-lipoxygenase-4	Glycine max	63-75
119581-5	1979	Lipoxygenase-catalyzed oxidation of furan (IV), which is inhibited by hydroquinone, is explained by a mechanism involving lipoxygenase-superoxide complex and furan-radical intermediates.	furan	36-41	linoleate 9S-lipoxygenase-4	Glycine max	0-12
119581-5	1979	Lipoxygenase-catalyzed oxidation of furan (IV), which is inhibited by hydroquinone, is explained by a mechanism involving lipoxygenase-superoxide complex and furan-radical intermediates.	furan	36-41	linoleate 9S-lipoxygenase-4	Glycine max	122-134
119581-5	1979	Lipoxygenase-catalyzed oxidation of furan (IV), which is inhibited by hydroquinone, is explained by a mechanism involving lipoxygenase-superoxide complex and furan-radical intermediates.	hydroquinone	70-82	linoleate 9S-lipoxygenase-4	Glycine max	0-12
119581-5	1979	Lipoxygenase-catalyzed oxidation of furan (IV), which is inhibited by hydroquinone, is explained by a mechanism involving lipoxygenase-superoxide complex and furan-radical intermediates.	hydroquinone	70-82	linoleate 9S-lipoxygenase-4	Glycine max	122-134
119581-5	1979	Lipoxygenase-catalyzed oxidation of furan (IV), which is inhibited by hydroquinone, is explained by a mechanism involving lipoxygenase-superoxide complex and furan-radical intermediates.	Superoxides	135-145	linoleate 9S-lipoxygenase-4	Glycine max	0-12
119581-5	1979	Lipoxygenase-catalyzed oxidation of furan (IV), which is inhibited by hydroquinone, is explained by a mechanism involving lipoxygenase-superoxide complex and furan-radical intermediates.	Superoxides	135-145	linoleate 9S-lipoxygenase-4	Glycine max	122-134
119581-5	1979	Lipoxygenase-catalyzed oxidation of furan (IV), which is inhibited by hydroquinone, is explained by a mechanism involving lipoxygenase-superoxide complex and furan-radical intermediates.	furan-radical	158-171	linoleate 9S-lipoxygenase-4	Glycine max	0-12
119581-1	1979	Several 2,5-disubstituted furans, which are known to react with peroxyacids, singlet oxygen and other active forms of oxygen were tested as potential inhibitors, co-oxidants, or substrates for soybean lipoxygenase.	Furans	26-32	linoleate 9S-lipoxygenase-4	Glycine max	201-213
119581-2	1979	The furan, 10,13-epoxy-octadeca-10,12-dienoic acid, methyl ester (IV) was converted by lipoxygenase or singlet oxygen or peroxyacid to the acyclic product, methyl 10,13-dioxo-octadec-11-enoate.	furan	4-9	linoleate 9S-lipoxygenase-4	Glycine max	87-99
119581-2	1979	The furan, 10,13-epoxy-octadeca-10,12-dienoic acid, methyl ester (IV) was converted by lipoxygenase or singlet oxygen or peroxyacid to the acyclic product, methyl 10,13-dioxo-octadec-11-enoate.	10,13-epoxy-octadeca-10,12-dienoic acid, methyl ester	11-64	linoleate 9S-lipoxygenase-4	Glycine max	87-99
111925-7	1979	With electron transfer particles the reticulocyte lipoxygenase causes a loss of acid-labile sulfur which accompanies respiratory inhibition; the strong respiratory inhibition is not exerted by soybean lipoxygenase.	Sulfur	92-98	linoleate 9S-lipoxygenase-4	Glycine max	50-62
409781-1	1977	Intradermal injection of as little as 500 ng of arachidonic acid or the metabolites from arachidonic acid incubated with soybean lipoxygenase produced infiltration of the upper dermis by polymorphonuclear leukocytes 18 hours after injection.	Arachidonic Acid	48-64	linoleate 9S-lipoxygenase-4	Glycine max	129-141
16660540-5	1978	Soybean lipoxygenase exhibits similar characteristics of insensitivity to cyanide and sensitivity to salicylhydroxamate and to propyl gallate.	Cyanides	74-81	linoleate 9S-lipoxygenase-4	Glycine max	8-20
16660540-5	1978	Soybean lipoxygenase exhibits similar characteristics of insensitivity to cyanide and sensitivity to salicylhydroxamate and to propyl gallate.	salicylhydroxamic acid	101-119	linoleate 9S-lipoxygenase-4	Glycine max	8-20
16660540-5	1978	Soybean lipoxygenase exhibits similar characteristics of insensitivity to cyanide and sensitivity to salicylhydroxamate and to propyl gallate.	Propyl Gallate	127-141	linoleate 9S-lipoxygenase-4	Glycine max	8-20
16660540-6	1978	The initial burst of respiration is enhanced by the addition of linoleic acid, a lipoxygenase substrate.	Linoleic Acid	64-77	linoleate 9S-lipoxygenase-4	Glycine max	81-93
16660540-7	1978	These results indicate that the conventional tests for alternate respiration in plant tissues can be confounded by lipoxygenase; they also suggest that propyl gallate can be used to assess the possible participation of lipoxygenase in the O(2) uptake by plant tissues.	o(2)	239-243	linoleate 9S-lipoxygenase-4	Glycine max	219-231
409781-1	1977	Intradermal injection of as little as 500 ng of arachidonic acid or the metabolites from arachidonic acid incubated with soybean lipoxygenase produced infiltration of the upper dermis by polymorphonuclear leukocytes 18 hours after injection.	Arachidonic Acid	89-105	linoleate 9S-lipoxygenase-4	Glycine max	129-141
822867-0	1976	Steady-state kinetics of lipoxygenase oxygenation of unsaturated fatty acids.	Fatty Acids, Unsaturated	53-76	linoleate 9S-lipoxygenase-4	Glycine max	25-37
409781-2	1977	In experiments comparing the chemotactic properties of four fatty acids in varying concentrations, oxidative products of arachidonic acid by soybean lipoxygenase were the most powerful followed by free arachidonic acid and free linoleic acid while stearic acid did not produce significant infiltration.	Fatty Acids	60-71	linoleate 9S-lipoxygenase-4	Glycine max	149-161
409781-2	1977	In experiments comparing the chemotactic properties of four fatty acids in varying concentrations, oxidative products of arachidonic acid by soybean lipoxygenase were the most powerful followed by free arachidonic acid and free linoleic acid while stearic acid did not produce significant infiltration.	Arachidonic Acid	121-137	linoleate 9S-lipoxygenase-4	Glycine max	149-161
409781-2	1977	In experiments comparing the chemotactic properties of four fatty acids in varying concentrations, oxidative products of arachidonic acid by soybean lipoxygenase were the most powerful followed by free arachidonic acid and free linoleic acid while stearic acid did not produce significant infiltration.	stearic acid	248-260	linoleate 9S-lipoxygenase-4	Glycine max	149-161
186306-0	1976	On the interaction of some catechol derivatives with the iron atom of soybean lipoxygenase.	catechol	27-35	linoleate 9S-lipoxygenase-4	Glycine max	78-90
186306-0	1976	On the interaction of some catechol derivatives with the iron atom of soybean lipoxygenase.	Iron	57-61	linoleate 9S-lipoxygenase-4	Glycine max	78-90
822867-1	1976	The oxygenation of linoleate and arachidonate catalyzed by soybean lipoxygenase is subject to competitive product inhibition.	Linoleic Acid	19-28	linoleate 9S-lipoxygenase-4	Glycine max	67-79
822867-1	1976	The oxygenation of linoleate and arachidonate catalyzed by soybean lipoxygenase is subject to competitive product inhibition.	Arachidonic Acid	33-45	linoleate 9S-lipoxygenase-4	Glycine max	67-79
812703-0	1976	The steady-state kinetics of the oxygenation of linoleic acid catalysed by soybean lipoxygenase.	Linoleic Acid	48-61	linoleate 9S-lipoxygenase-4	Glycine max	83-95
823735-0	1976	Co-oxydation of a carotenoid by the enzyme lipoxygenase: influence on the formation of linoleic acid hydroperoxides.	Carotenoids	18-28	linoleate 9S-lipoxygenase-4	Glycine max	43-55
823735-0	1976	Co-oxydation of a carotenoid by the enzyme lipoxygenase: influence on the formation of linoleic acid hydroperoxides.	linoleic acid hydroperoxide	87-115	linoleate 9S-lipoxygenase-4	Glycine max	43-55
823735-1	1976	A partially purified soybean lipoxygenase (L-3) was incubated for 15 min at pH 6.5 with linoleic acid and oxygen.	Linoleic Acid	88-101	linoleate 9S-lipoxygenase-4	Glycine max	29-41
813080-0	1975	Conversion of linoleic acid hydroperoxide by soybean lipoxygenase in the presence of guaiacol: identification of the reaction products.	linoleic acid hydroperoxide	14-41	linoleate 9S-lipoxygenase-4	Glycine max	53-65
813080-0	1975	Conversion of linoleic acid hydroperoxide by soybean lipoxygenase in the presence of guaiacol: identification of the reaction products.	Guaiacol	85-93	linoleate 9S-lipoxygenase-4	Glycine max	53-65
813080-1	1975	Linoleic acid hydroperoxide formed by soybean lipoxygenase was metabolized by the same enzyme in the presence of guaiacol.	linoleic acid hydroperoxide	0-27	linoleate 9S-lipoxygenase-4	Glycine max	46-58
813080-1	1975	Linoleic acid hydroperoxide formed by soybean lipoxygenase was metabolized by the same enzyme in the presence of guaiacol.	Guaiacol	113-121	linoleate 9S-lipoxygenase-4	Glycine max	46-58
809633-0	1975	Aerobic pentane production by soybean lipoxygenase isozymes.	pentane	8-15	linoleate 9S-lipoxygenase-4	Glycine max	38-50
811334-0	1975	Further studies of the kinetics of oxygenation of arachidonic acid by soybean lipoxygenase.	Arachidonic Acid	50-66	linoleate 9S-lipoxygenase-4	Glycine max	78-90
811334-3	1975	It has been confirmed that activation of lipoxygenase by its hydroperoxide product is necessary for activity, and product removal gives inhibition in a manner quantitatively predicted by the model.	Hydrogen Peroxide	61-74	linoleate 9S-lipoxygenase-4	Glycine max	41-53
809633-1	1975	The effects of oxygen on production of pentane and compounds absorbing at 234 nm and 285 nm by soybean lipoxygenase isozymes I and II were examined in a model system.	Oxygen	15-21	linoleate 9S-lipoxygenase-4	Glycine max	103-115
809633-1	1975	The effects of oxygen on production of pentane and compounds absorbing at 234 nm and 285 nm by soybean lipoxygenase isozymes I and II were examined in a model system.	pentane	39-46	linoleate 9S-lipoxygenase-4	Glycine max	103-115
4674505-0	1972	Structural requirements of acetylenic fatty acids for inhibition of soybean lipoxygenase and prostaglandin synthetase.	acetylenic fatty acids	27-49	linoleate 9S-lipoxygenase-4	Glycine max	76-88
27521073-2	1975	Chromatography on a column of silicic acid separated 13-hydroperoxy-11,9-octadecadienoic acid in 99+% purity from the mixture obtained by soybean lipoxygenase oxidation of linoleic acid.	Silicic Acid	30-42	linoleate 9S-lipoxygenase-4	Glycine max	146-158
27521073-2	1975	Chromatography on a column of silicic acid separated 13-hydroperoxy-11,9-octadecadienoic acid in 99+% purity from the mixture obtained by soybean lipoxygenase oxidation of linoleic acid.	13-hydroperoxy-11,9-octadecadienoic acid	53-93	linoleate 9S-lipoxygenase-4	Glycine max	146-158
27521073-2	1975	Chromatography on a column of silicic acid separated 13-hydroperoxy-11,9-octadecadienoic acid in 99+% purity from the mixture obtained by soybean lipoxygenase oxidation of linoleic acid.	Linoleic Acid	172-185	linoleate 9S-lipoxygenase-4	Glycine max	146-158
5459662-1	1970	Linoleic acid oxidation catalyzed by lipoxygenase (lipoxidase) activity in extracts of defatted corn germ does not terminate in the product, linoleic acid hydroperoxide, unless the lipoxygenase is first partially purified.	Linoleic Acid	0-13	linoleate 9S-lipoxygenase-4	Glycine max	37-49
32065346-0	2021	Novel quinolinone-pyrazoline hybrids: synthesis and evaluation of antioxidant and lipoxygenase inhibitory activity.	Quinolones	6-28	linoleate 9S-lipoxygenase-4	Glycine max	82-94
32065346-4	2021	Among all the pyrazoline derivatives, compounds 9b and 9m were found to possess the best combined activity, whereas 9b analogue exhibited the most potent LOX inhibitory activity, with IC50 value 10 muM.	3-trimethylsilyl-1-pyrazoline	14-24	linoleate 9S-lipoxygenase-4	Glycine max	154-157
33249836-3	2020	This study demonstrated that the formation of (E)-2-heptenal was independent of the lipoxygenase (LOX) and hydroperoxide lyase (HPL) activity as well as oxygen concentration but was related to the presence/absence of Fe2+ and chelators.	2-heptenal	46-60	linoleate 9S-lipoxygenase-4	Glycine max	84-96
33430075-2	2021	The maximal adsorption efficiency of soybean lipoxygenase to the silica particles was 50%.	Silicon Dioxide	65-71	linoleate 9S-lipoxygenase-4	Glycine max	45-57
33430075-3	2021	The desorption kinetics of soybean lipoxygenase from the silica particles indicate that the silica-immobilized enzyme is more stable in an anionic buffer (sodium phosphate, pH 7.2) than in a cationic buffer (Tris-HCl, pH 7.2).	Silicon Dioxide	57-63	linoleate 9S-lipoxygenase-4	Glycine max	35-47
33430075-3	2021	The desorption kinetics of soybean lipoxygenase from the silica particles indicate that the silica-immobilized enzyme is more stable in an anionic buffer (sodium phosphate, pH 7.2) than in a cationic buffer (Tris-HCl, pH 7.2).	Silicon Dioxide	92-98	linoleate 9S-lipoxygenase-4	Glycine max	35-47
33430075-3	2021	The desorption kinetics of soybean lipoxygenase from the silica particles indicate that the silica-immobilized enzyme is more stable in an anionic buffer (sodium phosphate, pH 7.2) than in a cationic buffer (Tris-HCl, pH 7.2).	sodium phosphate	155-171	linoleate 9S-lipoxygenase-4	Glycine max	35-47
33430075-3	2021	The desorption kinetics of soybean lipoxygenase from the silica particles indicate that the silica-immobilized enzyme is more stable in an anionic buffer (sodium phosphate, pH 7.2) than in a cationic buffer (Tris-HCl, pH 7.2).	Tris hydrochloride	208-216	linoleate 9S-lipoxygenase-4	Glycine max	35-47
33430075-7	2021	The thermal stability of the immobilized lipoxygenase was higher than the thermal stability of soluble lipoxygenase, demonstrating 70% and 45% of its optimal specific activity, respectively, after incubation for 30 min at 45  C. These results demonstrate that adsorption on nanoporous rice husk silica is a simple and rapid method for protein immobilization, and that adsorption may be a useful and facile method for the immobilization of many biologically important proteins of interest.	Silicon Dioxide	295-301	linoleate 9S-lipoxygenase-4	Glycine max	41-53
33249836-3	2020	This study demonstrated that the formation of (E)-2-heptenal was independent of the lipoxygenase (LOX) and hydroperoxide lyase (HPL) activity as well as oxygen concentration but was related to the presence/absence of Fe2+ and chelators.	2-heptenal	46-60	linoleate 9S-lipoxygenase-4	Glycine max	98-101
31757126-0	2019	Physicochemical Changes and in Vitro Gastric Digestion of Modified Soybean Protein Induced by Lipoxygenase Catalyzed Linoleic Acid Oxidation.	Linoleic Acid	117-130	linoleate 9S-lipoxygenase-4	Glycine max	94-106
33079529-0	2020	Physicochemical and Structural Characteristics of Soybean Protein Isolates Induced by Lipoxygenase-Catalyzed Linoleic Acid Oxidation during In Vitro Gastric Digestion.	Linoleic Acid	109-122	linoleate 9S-lipoxygenase-4	Glycine max	86-98
33079529-1	2020	The effects of oxidation on the gastric digestion properties of soybean protein isolates (SPIs) in a model of lipoxygenase (LOX)-catalyzed linoleic acid (LA) oxidation system and the multiscale structural characterization of SPI hydrolysate were investigated.	Linoleic Acid	139-152	linoleate 9S-lipoxygenase-4	Glycine max	110-122
31943295-4	2020	Coumarin 5e possessing a geranyloxy-chain on position 5 of the coumarin scaffold presented dual bioactivity, while 5-geranyloxy-coumarin 5f was the most competent soybean lipoxygenase inhibitor of this series (IC50 10 muM).	coumarin	115-139	linoleate 9S-lipoxygenase-4	Glycine max	171-183
32348134-0	2020	Gel properties of soy protein isolate modified by lipoxygenase catalyzed linoleic acid oxidation and their influence on pepsin diffusion and in vitro gastric digestion.	Linoleic Acid	73-86	linoleate 9S-lipoxygenase-4	Glycine max	50-62
32348134-1	2020	The model of lipoxygenase catalyzed linoleic acid (LA) oxidation was selected as a representative of lipid peroxidation system to investigate the effects of oxidative modification on soybean protein isolate (SPI) gel properties and in vitro gastric digestion.	Linoleic Acid	36-49	linoleate 9S-lipoxygenase-4	Glycine max	13-25
30359035-1	2018	Soybean lipoxygenase catalyzes a proton-coupled electron transfer (PCET) reaction and serves as a prototype for hydrogen tunneling in enzymes due to the unusually high kinetic isotope effect and significant modulation of the rate constant and kinetic isotope effect by mutation.	Hydrogen	112-120	linoleate 9S-lipoxygenase-4	Glycine max	8-20
31580070-1	2019	The rate-limiting chemical reaction catalyzed by soybean lipoxygenase (SLO) involves quantum mechanical tunneling of a hydrogen atom from substrate to its active site ferric-hydroxide cofactor.	Hydrogen	119-127	linoleate 9S-lipoxygenase-4	Glycine max	57-69
31580070-1	2019	The rate-limiting chemical reaction catalyzed by soybean lipoxygenase (SLO) involves quantum mechanical tunneling of a hydrogen atom from substrate to its active site ferric-hydroxide cofactor.	ferric hydroxide	167-183	linoleate 9S-lipoxygenase-4	Glycine max	57-69
31478006-5	2019	The results showed that the optimised SHS treatment could reduce the beany flavour in the soya milk significantly (P < 0.05) by reducing the specific LOX activity in the soybean, while ensuring the crude protein content in the soya milk complied with Malaysian Food Regulations 1985.	shs	38-41	linoleate 9S-lipoxygenase-4	Glycine max	153-156
30642482-0	2019	In vitro gastrointestinal digest of catechin-modified beta-conglycinin oxidized by lipoxygenase-catalyzed linoleic acid peroxidation.	Catechin	36-44	linoleate 9S-lipoxygenase-4	Glycine max	83-95
30642482-0	2019	In vitro gastrointestinal digest of catechin-modified beta-conglycinin oxidized by lipoxygenase-catalyzed linoleic acid peroxidation.	Linoleic Acid	106-119	linoleate 9S-lipoxygenase-4	Glycine max	83-95
30642482-1	2019	The aim of the present study was to enhance oxidative stability and bioaccessibility of beta-conglycinin (7S) prepared from low denatured defatted soybean flours with residual lipids and high lipoxygenase (LOX) activity.	ethyl-2-methylthio-4-methyl-5-pyrimidine carboxylate	106-108	linoleate 9S-lipoxygenase-4	Glycine max	192-204
30642482-1	2019	The aim of the present study was to enhance oxidative stability and bioaccessibility of beta-conglycinin (7S) prepared from low denatured defatted soybean flours with residual lipids and high lipoxygenase (LOX) activity.	ethyl-2-methylthio-4-methyl-5-pyrimidine carboxylate	106-108	linoleate 9S-lipoxygenase-4	Glycine max	206-209
30642482-3	2019	The interaction of UH-7S/H-7S with catechin dramatically inhibited LOX-catalyzed LA peroxidation-induced protein oxidation.	uh-7s	19-24	linoleate 9S-lipoxygenase-4	Glycine max	67-70
30642482-3	2019	The interaction of UH-7S/H-7S with catechin dramatically inhibited LOX-catalyzed LA peroxidation-induced protein oxidation.	h-7s	20-24	linoleate 9S-lipoxygenase-4	Glycine max	67-70
30642482-3	2019	The interaction of UH-7S/H-7S with catechin dramatically inhibited LOX-catalyzed LA peroxidation-induced protein oxidation.	Catechin	35-43	linoleate 9S-lipoxygenase-4	Glycine max	67-70
30724235-4	2019	Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis revealed that lipoxygenase was susceptible to heat denaturation, but 7S and 11S globulins were only partially denatured.	sodium dodecyl sulfate-polyacrylamide	0-37	linoleate 9S-lipoxygenase-4	Glycine max	81-93
29392938-1	2018	The proton-coupled electron transfer (PCET) reaction catalyzed by soybean lipoxygenase has served as a prototype for understanding hydrogen tunneling in enzymes.	Hydrogen	131-139	linoleate 9S-lipoxygenase-4	Glycine max	74-86
29970872-0	2018	Application of Docking Analysis in the Prediction and Biological Evaluation of the Lipoxygenase Inhibitory Action of Thiazolyl Derivatives of Mycophenolic Acid.	thiazolyl	117-126	linoleate 9S-lipoxygenase-4	Glycine max	83-95
29970872-0	2018	Application of Docking Analysis in the Prediction and Biological Evaluation of the Lipoxygenase Inhibitory Action of Thiazolyl Derivatives of Mycophenolic Acid.	Mycophenolic Acid	142-159	linoleate 9S-lipoxygenase-4	Glycine max	83-95
28691068-0	2017	Hydrogen-Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling.	Hydrogen	0-8	linoleate 9S-lipoxygenase-4	Glycine max	31-43
29191828-0	2018	Hydrogen-deuterium exchange reveals long-range dynamical allostery in soybean lipoxygenase.	Hydrogen	0-8	linoleate 9S-lipoxygenase-4	Glycine max	78-90
29191828-0	2018	Hydrogen-deuterium exchange reveals long-range dynamical allostery in soybean lipoxygenase.	Deuterium	9-18	linoleate 9S-lipoxygenase-4	Glycine max	78-90
29191828-5	2018	Herein, we employed hydrogen-deuterium exchange MS (HDXMS) to spatially resolve changes in protein conformation upon interaction of soybean lipoxygenase with a fatty acid surrogate, oleyl sulfate (OS), previously shown to act at a site separate from the substrate-binding site.	Hydrogen	20-28	linoleate 9S-lipoxygenase-4	Glycine max	140-152
29191828-5	2018	Herein, we employed hydrogen-deuterium exchange MS (HDXMS) to spatially resolve changes in protein conformation upon interaction of soybean lipoxygenase with a fatty acid surrogate, oleyl sulfate (OS), previously shown to act at a site separate from the substrate-binding site.	Deuterium	29-38	linoleate 9S-lipoxygenase-4	Glycine max	140-152
29191828-5	2018	Herein, we employed hydrogen-deuterium exchange MS (HDXMS) to spatially resolve changes in protein conformation upon interaction of soybean lipoxygenase with a fatty acid surrogate, oleyl sulfate (OS), previously shown to act at a site separate from the substrate-binding site.	Fatty Acids	160-170	linoleate 9S-lipoxygenase-4	Glycine max	140-152
29191828-5	2018	Herein, we employed hydrogen-deuterium exchange MS (HDXMS) to spatially resolve changes in protein conformation upon interaction of soybean lipoxygenase with a fatty acid surrogate, oleyl sulfate (OS), previously shown to act at a site separate from the substrate-binding site.	Oleyl sulfate	182-195	linoleate 9S-lipoxygenase-4	Glycine max	140-152
29191828-5	2018	Herein, we employed hydrogen-deuterium exchange MS (HDXMS) to spatially resolve changes in protein conformation upon interaction of soybean lipoxygenase with a fatty acid surrogate, oleyl sulfate (OS), previously shown to act at a site separate from the substrate-binding site.	Osmium	197-199	linoleate 9S-lipoxygenase-4	Glycine max	140-152
28691068-0	2017	Hydrogen-Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling.	Deuterium	9-18	linoleate 9S-lipoxygenase-4	Glycine max	31-43
29250456-1	2017	Soybean lipoxygenase (SLO) is a prototype for nonadiabatic hydrogen tunneling reactions and, as such, has served as the subject of numerous theoretical studies.	Hydrogen	59-67	linoleate 9S-lipoxygenase-4	Glycine max	8-20
27532889-0	2016	Computational Insights into Five- versus Six-Coordinate Iron Center in Ferrous Soybean Lipoxygenase.	Iron	56-60	linoleate 9S-lipoxygenase-4	Glycine max	87-99
27609488-5	2017	Finally, their inhibitory activity towards soybean lipoxygenase was evaluated, using linoleic acid as substrate.	Linoleic Acid	85-98	linoleate 9S-lipoxygenase-4	Glycine max	51-63
30496666-9	2017	Finally, their inhibitory activity toward soybean lipoxygenase was evaluated, using linoleic acid as substrate.The essential oil of 0. vulgare (OV-VL) presented the highest interaction with the stable radical DPPH (76.5%), followed by that of A. absinthium (54.7%).	Oils, Volatile	115-128	linoleate 9S-lipoxygenase-4	Glycine max	50-62
30496666-9	2017	Finally, their inhibitory activity toward soybean lipoxygenase was evaluated, using linoleic acid as substrate.The essential oil of 0. vulgare (OV-VL) presented the highest interaction with the stable radical DPPH (76.5%), followed by that of A. absinthium (54.7%).	1,1-diphenyl-2-picrylhydrazyl	209-213	linoleate 9S-lipoxygenase-4	Glycine max	50-62
26681513-0	2016	Design, synthesis of novel pyranotriazolopyrimidines and evaluation of their anti-soybean lipoxygenase, anti-xanthine oxidase, and cytotoxic activities.	pyranotriazolopyrimidines	27-52	linoleate 9S-lipoxygenase-4	Glycine max	90-102
27532889-1	2016	Soybean lipoxygenase (SLO) serves as a prototype for fundamental understanding of hydrogen tunneling in enzymes.	Hydrogen	82-90	linoleate 9S-lipoxygenase-4	Glycine max	8-20
26753816-0	2016	Synthesis and biological evaluation of novel 5-hydroxylaminoisoxazole derivatives as lipoxygenase inhibitors and metabolism enhancing agents.	5-hydroxylaminoisoxazole	45-69	linoleate 9S-lipoxygenase-4	Glycine max	85-97
26494261-0	2015	Esters of some non-steroidal anti-inflammatory drugs with cinnamyl alcohol are potent lipoxygenase inhibitors with enhanced anti-inflammatory activity.	Esters	0-6	linoleate 9S-lipoxygenase-4	Glycine max	86-98
27612190-4	2016	Their inhibitory activity toward soybean lipoxygenase was evaluated in vitro, using linoleic acid as a substrate.	Linoleic Acid	84-97	linoleate 9S-lipoxygenase-4	Glycine max	41-53
26494261-0	2015	Esters of some non-steroidal anti-inflammatory drugs with cinnamyl alcohol are potent lipoxygenase inhibitors with enhanced anti-inflammatory activity.	cinnamyl alcohol	58-74	linoleate 9S-lipoxygenase-4	Glycine max	86-98
26154975-1	2015	Soybean lipoxygenase-1 (SLO-1) is a paradigmatic enzyme system for studying the contribution of hydrogen tunneling to enzymatic proton-coupled electron transfer processes.	Hydrogen	96-104	linoleate 9S-lipoxygenase-4	Glycine max	8-20
25824465-5	2015	The scavenging ability of the complexes towards 1,1-diphenyl-picrylhydrazyl, 2,2"-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) and hydroxyl radicals was investigated and the in vitro inhibitory activity against soybean lipoxygenase was evaluated and complexes 4 and 5 were the more active compounds among those tested.	Hydroxyl Radical	135-152	linoleate 9S-lipoxygenase-4	Glycine max	223-235
25586578-0	2015	Characterization of an omega-6 linoleate lipoxygenase from Burkholderia thailandensis and its application in the production of 13-hydroxyoctadecadienoic acid.	13-hydroxy-9,11-octadecadienoic acid	127-157	linoleate 9S-lipoxygenase-4	Glycine max	41-53
25586578-6	2015	Under these conditions, linoleate 13-lipoxygenase from B. thailandensis produced 20.8 g l(-1) 13-HODE (70.2 mM) from 20 g l(-1) linoleic acid (71.3 mM) for 120 min, with a molar conversion yield of 98.5% and productivity of 10.4 g l(-1) h(-1).	Coriolic acid	94-101	linoleate 9S-lipoxygenase-4	Glycine max	37-49
25586578-6	2015	Under these conditions, linoleate 13-lipoxygenase from B. thailandensis produced 20.8 g l(-1) 13-HODE (70.2 mM) from 20 g l(-1) linoleic acid (71.3 mM) for 120 min, with a molar conversion yield of 98.5% and productivity of 10.4 g l(-1) h(-1).	Linoleic Acid	128-141	linoleate 9S-lipoxygenase-4	Glycine max	37-49
25586578-7	2015	The molar conversion yield and productivity of 13-HODE obtained using B. thailandensis lipoxygenase were 151 and 158% higher, respectively, than those obtained using commercial soybean lipoxygenase under the optimum conditions for each enzyme at the same concentrations of substrate and enzyme.	Coriolic acid	47-54	linoleate 9S-lipoxygenase-4	Glycine max	87-99
25586578-7	2015	The molar conversion yield and productivity of 13-HODE obtained using B. thailandensis lipoxygenase were 151 and 158% higher, respectively, than those obtained using commercial soybean lipoxygenase under the optimum conditions for each enzyme at the same concentrations of substrate and enzyme.	Coriolic acid	47-54	linoleate 9S-lipoxygenase-4	Glycine max	185-197
25886468-1	2015	BACKGROUND: Cyclooxygenase (COXs) and Lipoxygenase (LOXs) pathways are the two major enzymatic pathways in arachidonic acid (AA) metabolism.	Arachidonic Acid	107-123	linoleate 9S-lipoxygenase-4	Glycine max	38-50
25529698-1	2015	Lipoxygenase (LOX)-catalysed degradation of polyunsaturated fatty acids is supposed to be a major cause of undesirable off-flavour development in legumes.	Fatty Acids, Unsaturated	44-71	linoleate 9S-lipoxygenase-4	Glycine max	0-12
25529698-1	2015	Lipoxygenase (LOX)-catalysed degradation of polyunsaturated fatty acids is supposed to be a major cause of undesirable off-flavour development in legumes.	Fatty Acids, Unsaturated	44-71	linoleate 9S-lipoxygenase-4	Glycine max	14-17
25529698-7	2015	In contrast to soy and other legumes, LOX from lupin only converted free fatty acids, whereas trilinolein and beta-carotene were not oxidised.	Fatty Acids, Nonesterified	68-84	linoleate 9S-lipoxygenase-4	Glycine max	38-41
25886468-1	2015	BACKGROUND: Cyclooxygenase (COXs) and Lipoxygenase (LOXs) pathways are the two major enzymatic pathways in arachidonic acid (AA) metabolism.	Arachidonic Acid	107-123	linoleate 9S-lipoxygenase-4	Glycine max	52-56
25660964-3	2015	The ability of the complexes to scavenge 1,1-diphenyl-picrylhydrazyl, 2,2"-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) and hydroxyl radicals was investigated and the in vitro inhibitory activity against soybean lipoxygenase was evaluated; complexes 3 and 4 were the most active compounds.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	70-123	linoleate 9S-lipoxygenase-4	Glycine max	216-228
25660964-3	2015	The ability of the complexes to scavenge 1,1-diphenyl-picrylhydrazyl, 2,2"-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) and hydroxyl radicals was investigated and the in vitro inhibitory activity against soybean lipoxygenase was evaluated; complexes 3 and 4 were the most active compounds.	Hydroxyl Radical	128-145	linoleate 9S-lipoxygenase-4	Glycine max	216-228
25552290-4	2015	SA reduces the lipoxygenase (LOX) and hydroperoxide lyase (HPL) activity, which in turn resulted in reduction in the TBA number and carbonyl value in contrast to MJ.	2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine	0-2	linoleate 9S-lipoxygenase-4	Glycine max	15-27
25552290-4	2015	SA reduces the lipoxygenase (LOX) and hydroperoxide lyase (HPL) activity, which in turn resulted in reduction in the TBA number and carbonyl value in contrast to MJ.	2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine	0-2	linoleate 9S-lipoxygenase-4	Glycine max	29-32
25552290-4	2015	SA reduces the lipoxygenase (LOX) and hydroperoxide lyase (HPL) activity, which in turn resulted in reduction in the TBA number and carbonyl value in contrast to MJ.	tba	117-120	linoleate 9S-lipoxygenase-4	Glycine max	15-27
25552290-4	2015	SA reduces the lipoxygenase (LOX) and hydroperoxide lyase (HPL) activity, which in turn resulted in reduction in the TBA number and carbonyl value in contrast to MJ.	tba	117-120	linoleate 9S-lipoxygenase-4	Glycine max	29-32
26155826-0	2015	Fucophlorethol C, a phlorotannin as a lipoxygenase inhibitor.	fucophlorethol C	0-16	linoleate 9S-lipoxygenase-4	Glycine max	38-50
26155826-0	2015	Fucophlorethol C, a phlorotannin as a lipoxygenase inhibitor.	phlorotannin	20-32	linoleate 9S-lipoxygenase-4	Glycine max	38-50
26155826-1	2015	Fucophlorethol C, a phlorotannin, was isolated from the brown alga Colpomenia bullosa (Scyto-siphonaceae) as a novel lipoxygenase (LOX) inhibitor.	fucophlorethol C	0-16	linoleate 9S-lipoxygenase-4	Glycine max	117-129
26155826-1	2015	Fucophlorethol C, a phlorotannin, was isolated from the brown alga Colpomenia bullosa (Scyto-siphonaceae) as a novel lipoxygenase (LOX) inhibitor.	fucophlorethol C	0-16	linoleate 9S-lipoxygenase-4	Glycine max	131-134
26155826-1	2015	Fucophlorethol C, a phlorotannin, was isolated from the brown alga Colpomenia bullosa (Scyto-siphonaceae) as a novel lipoxygenase (LOX) inhibitor.	phlorotannin	20-32	linoleate 9S-lipoxygenase-4	Glycine max	117-129
26155826-3	2015	The compound inhibited a soybean LOX to the same extent as the known inhibitor nordihydroguaiaretic acid.	Masoprocol	79-104	linoleate 9S-lipoxygenase-4	Glycine max	33-36
26423719-0	2015	Pteridine-2,4-diamine derivatives as radical scavengers and inhibitors of lipoxygenase that can possess anti-inflammatory properties.	2,4-Diaminopteridine	0-21	linoleate 9S-lipoxygenase-4	Glycine max	74-86
26423719-7	2015	CONCLUSION: The 2,4-diaminopteridine core represents a new scaffold for lipoxygenase inhibition as well as sustaining anti-inflammatory properties.	2,4-diaminopteridine	16-36	linoleate 9S-lipoxygenase-4	Glycine max	72-84
25323520-0	2015	Aryl-acetic and cinnamic acids as lipoxygenase inhibitors with antioxidant, anti-inflammatory, and anticancer activity.	aryl-acetic and cinnamic acids	0-30	linoleate 9S-lipoxygenase-4	Glycine max	34-46
25323520-2	2015	Lipoxygenase pathway, catalyzing the first two steps of the transformation of arachidonic acid into leukotrienes is implicated in several processes such as cell differentiation, inflammation and carcinogenesis.	Arachidonic Acid	78-94	linoleate 9S-lipoxygenase-4	Glycine max	0-12
26155726-0	2015	In vitro, fluorescence-quenching and computational studies on the interaction between lipoxygenase and 5-hydroxy-3",4",7-trimethoxyflavone from Lippia nodiflora L. Lippia nodiflora L. is extensively used in traditional medicine for several medicinal purposes, including their use in inflammatory disorders.	5-hydroxy-3",4",7-trimethoxyflavone	103-138	linoleate 9S-lipoxygenase-4	Glycine max	86-98
25323520-2	2015	Lipoxygenase pathway, catalyzing the first two steps of the transformation of arachidonic acid into leukotrienes is implicated in several processes such as cell differentiation, inflammation and carcinogenesis.	Leukotrienes	100-112	linoleate 9S-lipoxygenase-4	Glycine max	0-12
26155726-1	2015	In this study, the folk use of L. nodiflora was validated using the isolated natural compound, 5-hydroxy-3",4",7-trimethoxyflavone (HTMF) by in vitro, fluorescence spectroscopic and molecular modeling studies with lipoxygenase (LOX), because LOX plays an essential role in inflammatory responses.	5-hydroxy-3",4",7-trimethoxyflavone	95-130	linoleate 9S-lipoxygenase-4	Glycine max	214-226
24767084-0	2014	Lipoxygenase inhibitory activity of alkyl protocatechuates.	alkyl protocatechuates	36-58	linoleate 9S-lipoxygenase-4	Glycine max	0-12
26155726-2	2015	In this perspective, the methanol extract and HTMF are shown to demonstrate prominent inhibitory activity against soybean lipoxygenase, with an IC50 value of 21.12 and 23.97 microg/ml, respectively.	Methanol	25-33	linoleate 9S-lipoxygenase-4	Glycine max	122-134
25467808-12	2014	In drought stressed plants, thiamethoxam induced (upregulated) expression of a thiamine biosynthetic enzyme (THIZ2) and gibberellin regulated protein (GRP), but repressed (downregulated) the expression of an apetala 2 (GmDREB2A;2), lipoxygenase (LIP), and SAM dependent carboxyl methyltransferase (SAM).	Thiamethoxam	28-40	linoleate 9S-lipoxygenase-4	Glycine max	232-244
25467808-12	2014	In drought stressed plants, thiamethoxam induced (upregulated) expression of a thiamine biosynthetic enzyme (THIZ2) and gibberellin regulated protein (GRP), but repressed (downregulated) the expression of an apetala 2 (GmDREB2A;2), lipoxygenase (LIP), and SAM dependent carboxyl methyltransferase (SAM).	Thiamethoxam	28-40	linoleate 9S-lipoxygenase-4	Glycine max	246-249
25456384-0	2014	Structural modifications of coumarin derivatives: Determination  of antioxidant and lipoxygenase (LOX) inhibitory activity.	coumarin	28-36	linoleate 9S-lipoxygenase-4	Glycine max	84-96
25456384-0	2014	Structural modifications of coumarin derivatives: Determination  of antioxidant and lipoxygenase (LOX) inhibitory activity.	coumarin	28-36	linoleate 9S-lipoxygenase-4	Glycine max	98-101
25456384-1	2014	In the present project, a series of coumarin analogues, were synthesised and evaluated for their antioxidant and soybean lipoxygenase inhibitory activity.	coumarin	36-44	linoleate 9S-lipoxygenase-4	Glycine max	121-133
25456384-3	2014	Prenyloxy-coumarins 9 and 10 displayed the best combined inhibition of lipid peroxidation and soybean lipoxygenase.	5-hydroxy-6-methoxy-7-(3-methyl-but-2-enyloxy)-2H-1-benzopyran-2-one	0-19	linoleate 9S-lipoxygenase-4	Glycine max	102-114
25456384-4	2014	Thiocoumarins 11 and 14 were identified as potent lipoxygenase inhibitors whereas hydrazone analogues 15 and 16 were efficient DPPH radical scavengers.	thiocoumarins	0-13	linoleate 9S-lipoxygenase-4	Glycine max	50-62
24767084-1	2014	Alkyl 3,4-dihydroxybenzoates (protocatechuates) inhibited linoleic acid peroxidation catalyzed by soybean lipoxygenase-1 (EC 1.13.11.12, Type 1).	alkyl 3,4-dihydroxybenzoates	0-28	linoleate 9S-lipoxygenase-4	Glycine max	106-118
24767084-1	2014	Alkyl 3,4-dihydroxybenzoates (protocatechuates) inhibited linoleic acid peroxidation catalyzed by soybean lipoxygenase-1 (EC 1.13.11.12, Type 1).	Linoleic Acid	58-71	linoleate 9S-lipoxygenase-4	Glycine max	106-118
24767084-5	2014	The allosteric (or cooperative) inhibition of soybean lipoxygenase-1 of longer alkyl protocatechuates is reversible but in combination with their iron binding ability to disrupt the active site competitively and to interact with the hydrophobic portion surrounding near the active site (sequential action).	alkyl protocatechuates	79-101	linoleate 9S-lipoxygenase-4	Glycine max	54-66
24767084-5	2014	The allosteric (or cooperative) inhibition of soybean lipoxygenase-1 of longer alkyl protocatechuates is reversible but in combination with their iron binding ability to disrupt the active site competitively and to interact with the hydrophobic portion surrounding near the active site (sequential action).	Iron	146-150	linoleate 9S-lipoxygenase-4	Glycine max	54-66
25312177-8	2014	Flavonoid aglycones showed stronger antioxidant and lipoxygenase inhibitory effects than their glycosides.	Flavonoids	0-9	linoleate 9S-lipoxygenase-4	Glycine max	52-64
25258676-4	2014	Herein these diagnostics are applied to a model of the active site of the enzyme soybean lipoxygenase, which catalyzes a PCET reaction that exhibits unusually high deuterium kinetic isotope effects at room temperature.	Deuterium	164-173	linoleate 9S-lipoxygenase-4	Glycine max	89-101
25100256-0	2014	Synthesis and docking studies of 2,4,6-trihydroxy-3-geranylacetophenone analogs as potential lipoxygenase inhibitor.	2,4,6-trihydroxy-3-geranylacetophenone	33-71	linoleate 9S-lipoxygenase-4	Glycine max	93-105
25312177-8	2014	Flavonoid aglycones showed stronger antioxidant and lipoxygenase inhibitory effects than their glycosides.	aglycones	10-19	linoleate 9S-lipoxygenase-4	Glycine max	52-64
25312177-9	2014	Lignoid glycosides showed moderate to weak antioxidant and lipoxygenase inhibitory effects.	Glycosides	8-18	linoleate 9S-lipoxygenase-4	Glycine max	59-71
25100256-1	2014	The natural product molecule 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) isolated from the medicinal plant Melicope ptelefolia was shown to exhibit potent lipoxygenase (LOX) inhibitory activity.	2,4,6-trihydroxy-3-geranylacetophenone	29-68	linoleate 9S-lipoxygenase-4	Glycine max	158-170
25100256-1	2014	The natural product molecule 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) isolated from the medicinal plant Melicope ptelefolia was shown to exhibit potent lipoxygenase (LOX) inhibitory activity.	2,4,6-trihydroxy-3-geranylacetophenone	29-68	linoleate 9S-lipoxygenase-4	Glycine max	172-175
25100256-1	2014	The natural product molecule 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) isolated from the medicinal plant Melicope ptelefolia was shown to exhibit potent lipoxygenase (LOX) inhibitory activity.	2,4,6-trihydroxy-3-geranylacetophenone	70-74	linoleate 9S-lipoxygenase-4	Glycine max	158-170
25100256-1	2014	The natural product molecule 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) isolated from the medicinal plant Melicope ptelefolia was shown to exhibit potent lipoxygenase (LOX) inhibitory activity.	2,4,6-trihydroxy-3-geranylacetophenone	70-74	linoleate 9S-lipoxygenase-4	Glycine max	172-175
25100256-2	2014	It is known that LOX plays an important role in inflammatory response as it catalyzes the oxidation of unsaturated fatty acids, such as linoleic acid to form hydroperoxides.	Fatty Acids, Unsaturated	103-126	linoleate 9S-lipoxygenase-4	Glycine max	17-20
25100256-2	2014	It is known that LOX plays an important role in inflammatory response as it catalyzes the oxidation of unsaturated fatty acids, such as linoleic acid to form hydroperoxides.	Linoleic Acid	136-149	linoleate 9S-lipoxygenase-4	Glycine max	17-20
25100256-2	2014	It is known that LOX plays an important role in inflammatory response as it catalyzes the oxidation of unsaturated fatty acids, such as linoleic acid to form hydroperoxides.	Hydrogen Peroxide	158-172	linoleate 9S-lipoxygenase-4	Glycine max	17-20
25100256-5	2014	All the synthesized analogs showed potent soybean 15-LOX inhibitory activity in a dose-dependent manner (IC50 = 10.31-27.61 muM) where compound 3e was two-fold more active than tHGA.	2,4,6-trihydroxy-3-geranylacetophenone	177-181	linoleate 9S-lipoxygenase-4	Glycine max	53-56
24729578-1	2014	Caulerpenyne (CYN) is a sesquiterpene from green algae with known inhibitory properties against soybean lipoxygenase.	caulerpenyne	0-12	linoleate 9S-lipoxygenase-4	Glycine max	104-116
24729578-1	2014	Caulerpenyne (CYN) is a sesquiterpene from green algae with known inhibitory properties against soybean lipoxygenase.	caulerpenyne	14-17	linoleate 9S-lipoxygenase-4	Glycine max	104-116
24729578-4	2014	The modes of 5-LO inhibition by CYN and the synthetic inhibitors cannot be assigned to any of the known categories of lipoxygenase inhibitors.	caulerpenyne	32-35	linoleate 9S-lipoxygenase-4	Glycine max	118-130
24631827-4	2014	After the separation, the bands were digested, and, in addition to others, the following proteins, previously associated with metals, were identified: 3-lipoxygenase A chain (soybean) complex with 13(S)-hydroperoxy-9(Z),11(E)-octadecadienoic acid, beta-amylase [Glycine max], seed lipoxygenase-1, lipoxygenase [G. max], seed lipoxygenase-2 (Pisum sativum) and beta-conglycinin.	octadecadienoic acid	226-246	linoleate 9S-lipoxygenase-4	Glycine max	153-165
24938495-0	2014	Pharmacological evaluation and docking studies of alpha,beta-unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and proinflammatory cytokines.	alpha,beta-unsaturated carbonyl based	50-87	linoleate 9S-lipoxygenase-4	Glycine max	170-182
24463435-4	2014	Complex 1 and previously reported Zn-tolfenamato complexes were tested for their free radical scavenging activity and in vitro inhibitory activity against soybean lipoxygenase and exhibited significant activity with [Zn(tolf)2(1,10-phenantroline)] being the most active compound.	zn-tolfenamato	34-48	linoleate 9S-lipoxygenase-4	Glycine max	163-175
24359271-0	2014	Ascorbic acid 6-palmitate: a potent inhibitor of human and soybean lipoxygenase-dependent lipid peroxidation.	6-O-palmitoylascorbic acid	0-25	linoleate 9S-lipoxygenase-4	Glycine max	67-79
24296456-0	2014	Enzymatic production of 15-hydroxyeicosatetraenoic acid from arachidonic acid by using soybean lipoxygenase.	Eicosatetraenoic acid, 15-hydroxy-	24-55	linoleate 9S-lipoxygenase-4	Glycine max	95-107
24296456-0	2014	Enzymatic production of 15-hydroxyeicosatetraenoic acid from arachidonic acid by using soybean lipoxygenase.	Arachidonic Acid	61-77	linoleate 9S-lipoxygenase-4	Glycine max	95-107
24296456-2	2014	The conditions of producing 15-HETE from arachidonic acid by using soybean lipoxygenase were optimal at pH 8.5 and 20 C with 9 g/l arachidonic acid, 54.4 U/ml soybean lipoxygenase, and 4% methanol.	15-Hete	28-35	linoleate 9S-lipoxygenase-4	Glycine max	75-87
24296456-2	2014	The conditions of producing 15-HETE from arachidonic acid by using soybean lipoxygenase were optimal at pH 8.5 and 20 C with 9 g/l arachidonic acid, 54.4 U/ml soybean lipoxygenase, and 4% methanol.	15-Hete	28-35	linoleate 9S-lipoxygenase-4	Glycine max	167-179
24296456-2	2014	The conditions of producing 15-HETE from arachidonic acid by using soybean lipoxygenase were optimal at pH 8.5 and 20 C with 9 g/l arachidonic acid, 54.4 U/ml soybean lipoxygenase, and 4% methanol.	Arachidonic Acid	41-57	linoleate 9S-lipoxygenase-4	Glycine max	75-87
24296456-2	2014	The conditions of producing 15-HETE from arachidonic acid by using soybean lipoxygenase were optimal at pH 8.5 and 20 C with 9 g/l arachidonic acid, 54.4 U/ml soybean lipoxygenase, and 4% methanol.	Arachidonic Acid	41-57	linoleate 9S-lipoxygenase-4	Glycine max	167-179
24296456-2	2014	The conditions of producing 15-HETE from arachidonic acid by using soybean lipoxygenase were optimal at pH 8.5 and 20 C with 9 g/l arachidonic acid, 54.4 U/ml soybean lipoxygenase, and 4% methanol.	Arachidonic Acid	131-147	linoleate 9S-lipoxygenase-4	Glycine max	75-87
24296456-2	2014	The conditions of producing 15-HETE from arachidonic acid by using soybean lipoxygenase were optimal at pH 8.5 and 20 C with 9 g/l arachidonic acid, 54.4 U/ml soybean lipoxygenase, and 4% methanol.	Methanol	188-196	linoleate 9S-lipoxygenase-4	Glycine max	75-87
24463435-4	2014	Complex 1 and previously reported Zn-tolfenamato complexes were tested for their free radical scavenging activity and in vitro inhibitory activity against soybean lipoxygenase and exhibited significant activity with [Zn(tolf)2(1,10-phenantroline)] being the most active compound.	zn(tolf)2(1,10-phenantroline)	217-246	linoleate 9S-lipoxygenase-4	Glycine max	163-175
24495846-7	2014	This is the first report on lipoxygenase inhibition of exo-methylenic alkapolyenes and a chlorophyll a-related substance.	exo-methylenic alkapolyenes	55-82	linoleate 9S-lipoxygenase-4	Glycine max	28-40
24495846-7	2014	This is the first report on lipoxygenase inhibition of exo-methylenic alkapolyenes and a chlorophyll a-related substance.	chlorophyll a	89-102	linoleate 9S-lipoxygenase-4	Glycine max	28-40
24176359-1	2014	Lipoxygenase (Lox) mediated oxidation of polyunsaturated fatty acids (PUFA) in mature soya seeds results in objectionable flavour.	Fatty Acids, Unsaturated	41-68	linoleate 9S-lipoxygenase-4	Glycine max	0-12
24176359-1	2014	Lipoxygenase (Lox) mediated oxidation of polyunsaturated fatty acids (PUFA) in mature soya seeds results in objectionable flavour.	Fatty Acids, Unsaturated	41-68	linoleate 9S-lipoxygenase-4	Glycine max	14-17
24176359-1	2014	Lipoxygenase (Lox) mediated oxidation of polyunsaturated fatty acids (PUFA) in mature soya seeds results in objectionable flavour.	Fatty Acids, Unsaturated	70-74	linoleate 9S-lipoxygenase-4	Glycine max	0-12
24176359-1	2014	Lipoxygenase (Lox) mediated oxidation of polyunsaturated fatty acids (PUFA) in mature soya seeds results in objectionable flavour.	Fatty Acids, Unsaturated	70-74	linoleate 9S-lipoxygenase-4	Glycine max	14-17
24176359-5	2014	Pure Lox-1 displayed unbiased response towards substrates with marginal preference (1.2-fold) for linoleic acid at its optimum pH.	Linoleic Acid	98-111	linoleate 9S-lipoxygenase-4	Glycine max	5-8
23856367-0	2013	Effect of endocannabinoids on soybean lipoxygenase-1 activity.	Endocannabinoids	10-26	linoleate 9S-lipoxygenase-4	Glycine max	38-50
23909602-2	2013	The lipoxygenase pathway produces and releases jasmonic acid, involved in the regulation of the plant defense genes, which encodes protease inhibitor (PI) production.	jasmonic acid	47-60	linoleate 9S-lipoxygenase-4	Glycine max	4-16
23856367-2	2013	Lipoxygenase activity has been known to be affected by unsaturated fatty acids or phenolic compounds.	Fatty Acids, Unsaturated	55-78	linoleate 9S-lipoxygenase-4	Glycine max	0-12
23856367-3	2013	In this study, we examined whether endocannabinoids containing both N-acyl group and phenolic group can affect the activity of soybean lipoxygenase (LOX)-1, similar to mammalian 15-lipoxygenase in physicochemical properties.	Endocannabinoids	35-51	linoleate 9S-lipoxygenase-4	Glycine max	135-147
23856367-8	2013	Taken together, it is proposed that endocannabinoids containing polyunsaturated acyl moiety and phenolic group may be efficient for the inhibition as well as inactivation of 15-lipoxygenase.	Endocannabinoids	36-52	linoleate 9S-lipoxygenase-4	Glycine max	177-189
22449314-0	2012	Methods for identifying lipoxygenase producing microorganisms on agar plates.	Agar	65-69	linoleate 9S-lipoxygenase-4	Glycine max	24-36
23528572-9	2013	All compounds have been tested for their antioxidant and free radical scavenging activity as well as for their in vitro inhibitory activity against soybean lipoxygenase showing significant activity with [Cu(fluf)(phen)Cl] being the most active.	cu(fluf)(phen)cl	204-220	linoleate 9S-lipoxygenase-4	Glycine max	156-168
23123338-9	2013	In particular, 1 presents significant inhibitory activity on LOX, with IC(50)=30 muM and selectivity to the inhibition of superoxide anion radicals and thus a promising candidate as a superoxide dismutase (SOD) biomimetic.	Superoxides	122-147	linoleate 9S-lipoxygenase-4	Glycine max	61-64
23200047-1	2012	Lipoxygenase enzymes initiate diverse signaling pathways by specifically directing oxygen to different carbons of arachidonate and other polyunsaturated acyl chains, but structural origins of this specificity have remained unclear.	Carbon	103-110	linoleate 9S-lipoxygenase-4	Glycine max	0-12
23200047-1	2012	Lipoxygenase enzymes initiate diverse signaling pathways by specifically directing oxygen to different carbons of arachidonate and other polyunsaturated acyl chains, but structural origins of this specificity have remained unclear.	Arachidonic Acid	114-126	linoleate 9S-lipoxygenase-4	Glycine max	0-12
22741794-0	2012	Biological evaluation of mechlorethamine-Pt(II) complex, part II: antimicrobial screening and lox study of the complex and its ligand.	mechlorethamine-pt(ii)	25-47	linoleate 9S-lipoxygenase-4	Glycine max	94-97
22741794-9	2012	UV absorbance-based enzyme assays were performed with HN2xHCl and [H2N2](2)[PtCl(4)] complex, in order to evaluate their in vitro inhibitory activity of soybean lipoxygenase (LOX), also.	platinum tetrachloride	76-83	linoleate 9S-lipoxygenase-4	Glycine max	161-173
22741794-9	2012	UV absorbance-based enzyme assays were performed with HN2xHCl and [H2N2](2)[PtCl(4)] complex, in order to evaluate their in vitro inhibitory activity of soybean lipoxygenase (LOX), also.	platinum tetrachloride	76-83	linoleate 9S-lipoxygenase-4	Glycine max	175-178
23997905-0	2013	New Insight into the SAR of Pyrimido [4,5-b][1,4] Benzothiazines as 15-lipoxygenase Inhibitors.	pyrimido [4,5-b][1,4] benzothiazines	28-64	linoleate 9S-lipoxygenase-4	Glycine max	71-83
23997905-1	2013	OBJECTIVE(S): Recently we reported that the soybean 15-lipoxygenase (SLO) inhibitory activity of pyrimido[4,5-b][l,4]benzothiazines largely depends on the orientation of sulfur atom of thiazine core towards Fe(III)-OH in the active site pocket of the enzyme with subsequent oxidation of sulfur to sulfoxide.	pyrimido[4,5-b][l,4]benzothiazines	97-131	linoleate 9S-lipoxygenase-4	Glycine max	55-67
23997905-1	2013	OBJECTIVE(S): Recently we reported that the soybean 15-lipoxygenase (SLO) inhibitory activity of pyrimido[4,5-b][l,4]benzothiazines largely depends on the orientation of sulfur atom of thiazine core towards Fe(III)-OH in the active site pocket of the enzyme with subsequent oxidation of sulfur to sulfoxide.	Sulfur	170-176	linoleate 9S-lipoxygenase-4	Glycine max	55-67
23997905-1	2013	OBJECTIVE(S): Recently we reported that the soybean 15-lipoxygenase (SLO) inhibitory activity of pyrimido[4,5-b][l,4]benzothiazines largely depends on the orientation of sulfur atom of thiazine core towards Fe(III)-OH in the active site pocket of the enzyme with subsequent oxidation of sulfur to sulfoxide.	Thiazines	122-130	linoleate 9S-lipoxygenase-4	Glycine max	55-67
23997905-1	2013	OBJECTIVE(S): Recently we reported that the soybean 15-lipoxygenase (SLO) inhibitory activity of pyrimido[4,5-b][l,4]benzothiazines largely depends on the orientation of sulfur atom of thiazine core towards Fe(III)-OH in the active site pocket of the enzyme with subsequent oxidation of sulfur to sulfoxide.	fe(iii)-oh	207-217	linoleate 9S-lipoxygenase-4	Glycine max	55-67
23997905-1	2013	OBJECTIVE(S): Recently we reported that the soybean 15-lipoxygenase (SLO) inhibitory activity of pyrimido[4,5-b][l,4]benzothiazines largely depends on the orientation of sulfur atom of thiazine core towards Fe(III)-OH in the active site pocket of the enzyme with subsequent oxidation of sulfur to sulfoxide.	Sulfur	287-293	linoleate 9S-lipoxygenase-4	Glycine max	55-67
23997905-1	2013	OBJECTIVE(S): Recently we reported that the soybean 15-lipoxygenase (SLO) inhibitory activity of pyrimido[4,5-b][l,4]benzothiazines largely depends on the orientation of sulfur atom of thiazine core towards Fe(III)-OH in the active site pocket of the enzyme with subsequent oxidation of sulfur to sulfoxide.	sulfoxide	297-306	linoleate 9S-lipoxygenase-4	Glycine max	55-67
23997905-5	2013	Results : The inhibitory activity of synthetic 2-substituted pyrimido[4,5-b][l,4]benzothiazines against soybean 15-lipoxygenase (SLO) was evaluated and structure activity relationships and binding modes of their 4-H and 4-methyl analogs were studied using docking analysis and ab initio calculations.	2-substituted pyrimido[4,5-b][l,4]benzothiazines	47-95	linoleate 9S-lipoxygenase-4	Glycine max	115-127
23997905-6	2013	DISCUSSION: The results of these studies showed that the lack of 4-methyl substituent in the pyrimido[4,5-b][1,4]benzothiazine molecules greatly reduces their lipoxygenase inhibitory activities and it was also found that the HOMO energy difference between the 4-H and 4-Methyl analogs can be responsible for the observed inhibitory activity reduction.	5H-Pyrimido[4,5-b][1,4]benzothiazine	93-126	linoleate 9S-lipoxygenase-4	Glycine max	159-171
23460823-8	2013	Deep analyses of the proteins and pathways showed that lipids were degraded through lipoxygenase dependent pathway and proteins were degraded through both protease and 26S proteosome system, and the lipoxygenase could also help to remove the reactive oxygen species during the rapid mobilization of reserves of soybean germinating seeds.	Reactive Oxygen Species	242-265	linoleate 9S-lipoxygenase-4	Glycine max	84-96
23460823-8	2013	Deep analyses of the proteins and pathways showed that lipids were degraded through lipoxygenase dependent pathway and proteins were degraded through both protease and 26S proteosome system, and the lipoxygenase could also help to remove the reactive oxygen species during the rapid mobilization of reserves of soybean germinating seeds.	Reactive Oxygen Species	242-265	linoleate 9S-lipoxygenase-4	Glycine max	199-211
22449314-1	2012	Plate assays for lipoxygenase producing microorganisms on agar plates have been developed.	Agar	58-62	linoleate 9S-lipoxygenase-4	Glycine max	17-29
22449314-2	2012	Both potassium iodide-starch and indamine dye formation methods were effective for detecting soybean lipoxygenase activity on agar plates.	potassium iodide-starch	5-28	linoleate 9S-lipoxygenase-4	Glycine max	101-113
22449314-2	2012	Both potassium iodide-starch and indamine dye formation methods were effective for detecting soybean lipoxygenase activity on agar plates.	N1-(4-Aminophenyl)benzene-1,4-diamine	33-41	linoleate 9S-lipoxygenase-4	Glycine max	101-113
22449314-2	2012	Both potassium iodide-starch and indamine dye formation methods were effective for detecting soybean lipoxygenase activity on agar plates.	Agar	126-130	linoleate 9S-lipoxygenase-4	Glycine max	101-113
22449314-4	2012	The potassium iodide-starch and indamine dye formation methods were also applied for detecting lipoxygenase production by Trichoderma reesei and Pichia pastoris transformants expressing the lipoxygenase gene of the fungus Gaeumannomyces graminis.	potassium iodide-starch	4-27	linoleate 9S-lipoxygenase-4	Glycine max	95-107
22449314-4	2012	The potassium iodide-starch and indamine dye formation methods were also applied for detecting lipoxygenase production by Trichoderma reesei and Pichia pastoris transformants expressing the lipoxygenase gene of the fungus Gaeumannomyces graminis.	potassium iodide-starch	4-27	linoleate 9S-lipoxygenase-4	Glycine max	190-202
22449314-4	2012	The potassium iodide-starch and indamine dye formation methods were also applied for detecting lipoxygenase production by Trichoderma reesei and Pichia pastoris transformants expressing the lipoxygenase gene of the fungus Gaeumannomyces graminis.	N1-(4-Aminophenyl)benzene-1,4-diamine	32-40	linoleate 9S-lipoxygenase-4	Glycine max	95-107
22449314-6	2012	For detection of the G. graminis lipoxygenase produced by Aspergillus nidulans the potassium iodide-starch method was successful.	potassium iodide-starch	83-106	linoleate 9S-lipoxygenase-4	Glycine max	33-45
22449314-7	2012	When Escherichia coli was grown on agar and soybean lipoxygenase was applied on the culture lipoxygenase activity could clearly be detected by the indamine dye formation method.	Indamine dye	147-159	linoleate 9S-lipoxygenase-4	Glycine max	52-64
22449314-7	2012	When Escherichia coli was grown on agar and soybean lipoxygenase was applied on the culture lipoxygenase activity could clearly be detected by the indamine dye formation method.	Indamine dye	147-159	linoleate 9S-lipoxygenase-4	Glycine max	92-104
21497583-3	2011	In vitro antioxidant activity of free ligands and their respective copper complexes includes: a) interaction with 1,1-diphenyl-2-picrylhydrazyl stable free radical, b) the EtaOmicron  mediated oxidation of DMSO, c) scavenging of superoxide anion radicals, d) inhibition of lipid peroxidation and e) soybean lipoxygenase inhibition.	Copper	67-73	linoleate 9S-lipoxygenase-4	Glycine max	307-319
21497583-3	2011	In vitro antioxidant activity of free ligands and their respective copper complexes includes: a) interaction with 1,1-diphenyl-2-picrylhydrazyl stable free radical, b) the EtaOmicron  mediated oxidation of DMSO, c) scavenging of superoxide anion radicals, d) inhibition of lipid peroxidation and e) soybean lipoxygenase inhibition.	etaomicron	172-182	linoleate 9S-lipoxygenase-4	Glycine max	307-319
21497583-3	2011	In vitro antioxidant activity of free ligands and their respective copper complexes includes: a) interaction with 1,1-diphenyl-2-picrylhydrazyl stable free radical, b) the EtaOmicron  mediated oxidation of DMSO, c) scavenging of superoxide anion radicals, d) inhibition of lipid peroxidation and e) soybean lipoxygenase inhibition.	Dimethyl Sulfoxide	206-210	linoleate 9S-lipoxygenase-4	Glycine max	307-319
20020224-0	2010	A proof for substitution of endogenous iron (II) in lipoxygenase by exogenous Cu2+.	ammonium ferrous sulfate	39-48	linoleate 9S-lipoxygenase-4	Glycine max	52-64
21106277-0	2011	Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities.	acrylic acid	61-73	linoleate 9S-lipoxygenase-4	Glycine max	96-108
21106277-1	2011	A series of novel acrylic acid derivatives bearing at the 3 position thienyl, furfuryl and 3,5-ditert-butyl-4-hydroxyphenyl substituents have been designed, synthesized and tested as potential dual lipoxygenase/cyclooxygenase-1 (LOX/COX-1) inhibitors and as antioxidant and anti-inflammatory agents.	acrylic acid	18-30	linoleate 9S-lipoxygenase-4	Glycine max	198-210
21106277-1	2011	A series of novel acrylic acid derivatives bearing at the 3 position thienyl, furfuryl and 3,5-ditert-butyl-4-hydroxyphenyl substituents have been designed, synthesized and tested as potential dual lipoxygenase/cyclooxygenase-1 (LOX/COX-1) inhibitors and as antioxidant and anti-inflammatory agents.	acrylic acid	18-30	linoleate 9S-lipoxygenase-4	Glycine max	229-232
20020224-0	2010	A proof for substitution of endogenous iron (II) in lipoxygenase by exogenous Cu2+.	cupric ion	78-82	linoleate 9S-lipoxygenase-4	Glycine max	52-64
20020224-1	2010	Soybean lipoxygenase (LOX) contains endogenous iron (II) at the active site, which is important for the enzyme activity.	ammonium ferrous sulfate	47-56	linoleate 9S-lipoxygenase-4	Glycine max	8-20
20020224-1	2010	Soybean lipoxygenase (LOX) contains endogenous iron (II) at the active site, which is important for the enzyme activity.	ammonium ferrous sulfate	47-56	linoleate 9S-lipoxygenase-4	Glycine max	22-25
20020224-2	2010	The activity of LOX can be accelerated by some exogenous metal ions including Cu2+.	Metals	57-62	linoleate 9S-lipoxygenase-4	Glycine max	16-19
20020224-2	2010	The activity of LOX can be accelerated by some exogenous metal ions including Cu2+.	cupric ion	78-82	linoleate 9S-lipoxygenase-4	Glycine max	16-19
20020224-3	2010	However, the mechanism of the activity improvement caused by exogenous metal ions remains unclear, not only for LOX but for most other metalloenzymes.	Metals	71-76	linoleate 9S-lipoxygenase-4	Glycine max	112-115
20020224-5	2010	In this paper, a quantitative proof of replacing iron (II) inside LOX by exogenous Cu2+ was provided, simply using UV-Vis spectrometry with two indicators p-carboxylantipyrylazo and 9-(4-carboxyphenyl)-2,3,7-trihydroxyl-6-fluorine.	ammonium ferrous sulfate	49-58	linoleate 9S-lipoxygenase-4	Glycine max	66-69
20020224-5	2010	In this paper, a quantitative proof of replacing iron (II) inside LOX by exogenous Cu2+ was provided, simply using UV-Vis spectrometry with two indicators p-carboxylantipyrylazo and 9-(4-carboxyphenyl)-2,3,7-trihydroxyl-6-fluorine.	cupric ion	83-87	linoleate 9S-lipoxygenase-4	Glycine max	66-69
20020224-5	2010	In this paper, a quantitative proof of replacing iron (II) inside LOX by exogenous Cu2+ was provided, simply using UV-Vis spectrometry with two indicators p-carboxylantipyrylazo and 9-(4-carboxyphenyl)-2,3,7-trihydroxyl-6-fluorine.	p-carboxylantipyrylazo	155-177	linoleate 9S-lipoxygenase-4	Glycine max	66-69
20020224-5	2010	In this paper, a quantitative proof of replacing iron (II) inside LOX by exogenous Cu2+ was provided, simply using UV-Vis spectrometry with two indicators p-carboxylantipyrylazo and 9-(4-carboxyphenyl)-2,3,7-trihydroxyl-6-fluorine.	9-(4-carboxyphenyl)-2,3,7-trihydroxyl-6-fluorine	182-230	linoleate 9S-lipoxygenase-4	Glycine max	66-69
20020224-6	2010	A 0.56 microM free iron (II) was observed in the bulk solution after incubating 9.45 microM Cu2+ with 16.10 microM LOX at 20 degrees C for 5 min, which is in coincidence with the decrement of Cu2+ in the bulk solution (0.53 microM), implying that iron (II) was replaced by Cu2+.	ammonium ferrous sulfate	19-28	linoleate 9S-lipoxygenase-4	Glycine max	115-118
20020224-6	2010	A 0.56 microM free iron (II) was observed in the bulk solution after incubating 9.45 microM Cu2+ with 16.10 microM LOX at 20 degrees C for 5 min, which is in coincidence with the decrement of Cu2+ in the bulk solution (0.53 microM), implying that iron (II) was replaced by Cu2+.	cupric ion	92-96	linoleate 9S-lipoxygenase-4	Glycine max	115-118
20636262-0	2010	Hexadecanoid pathway in plants: Lipoxygenase dioxygenation of (7Z,10Z,13Z)-hexadecatrienoic acid.	hexadecanoid	0-12	linoleate 9S-lipoxygenase-4	Glycine max	32-44
20627725-0	2010	A novel synthesis of 3-aryl coumarins and evaluation of their antioxidant and lipoxygenase inhibitory activity.	3-aryl coumarins	21-37	linoleate 9S-lipoxygenase-4	Glycine max	78-90
20422316-5	2010	Also, the double lipoxygenation and bond-isomerization of DHA into 10(S),17(S)-docosahexa-4Z,7Z,11E,13Z,15E,19Z-enoic acid, named PDX, by soybean lipoxygenase is described.	Docosahexaenoic Acids	58-61	linoleate 9S-lipoxygenase-4	Glycine max	146-158
20422316-5	2010	Also, the double lipoxygenation and bond-isomerization of DHA into 10(S),17(S)-docosahexa-4Z,7Z,11E,13Z,15E,19Z-enoic acid, named PDX, by soybean lipoxygenase is described.	17(s)-docosahexa-4z,7z	73-95	linoleate 9S-lipoxygenase-4	Glycine max	146-158
20422316-5	2010	Also, the double lipoxygenation and bond-isomerization of DHA into 10(S),17(S)-docosahexa-4Z,7Z,11E,13Z,15E,19Z-enoic acid, named PDX, by soybean lipoxygenase is described.	-enoic acid	111-122	linoleate 9S-lipoxygenase-4	Glycine max	146-158
20082280-0	2010	Trapping of fatty acid allyl radicals generated in lipoxygenase reactions in biological fluids by nitroxyl radical.	fatty acid allyl radicals	12-37	linoleate 9S-lipoxygenase-4	Glycine max	51-63
20082280-0	2010	Trapping of fatty acid allyl radicals generated in lipoxygenase reactions in biological fluids by nitroxyl radical.	aminoxyl	98-114	linoleate 9S-lipoxygenase-4	Glycine max	51-63
20082280-1	2010	Nitroxyl radicals can trap fatty acid allyl radicals on ferric-lipoxygenases at lower oxygen content, which are an intermediate in the lipoxygenase reaction.	nitroxyl radicals	0-17	linoleate 9S-lipoxygenase-4	Glycine max	63-75
20082280-1	2010	Nitroxyl radicals can trap fatty acid allyl radicals on ferric-lipoxygenases at lower oxygen content, which are an intermediate in the lipoxygenase reaction.	fatty acid allyl radicals	27-52	linoleate 9S-lipoxygenase-4	Glycine max	63-75
20082280-7	2010	It is proved for the first time that nitroxyl radical traps fatty acid allyl radicals generated in the lipoxygenase reaction in biological fluid without competition from endogenous antioxidants.	nitroxyl radical traps fatty acid	37-70	linoleate 9S-lipoxygenase-4	Glycine max	103-115
20082280-7	2010	It is proved for the first time that nitroxyl radical traps fatty acid allyl radicals generated in the lipoxygenase reaction in biological fluid without competition from endogenous antioxidants.	allyl radicals	71-85	linoleate 9S-lipoxygenase-4	Glycine max	103-115
20636262-0	2010	Hexadecanoid pathway in plants: Lipoxygenase dioxygenation of (7Z,10Z,13Z)-hexadecatrienoic acid.	roughanic acid	62-96	linoleate 9S-lipoxygenase-4	Glycine max	32-44
20636262-4	2010	The recombinant maize 9-lipoxygenase specifically converted 16:3 into (7S)-hydroperoxide.	(7s)-hydroperoxide	70-88	linoleate 9S-lipoxygenase-4	Glycine max	24-36
20636262-8	2010	Lipoxygenase 2 produced 7-, 8-, 10-, 11-, 13-, and 14-hydroperoxides of 16:3, as well as a significant amount of bis-allylic 9-hydroperoxide.	7-, 8-, 10-, 11-, 13-, and 14-hydroperoxides	24-68	linoleate 9S-lipoxygenase-4	Glycine max	0-12
20636262-8	2010	Lipoxygenase 2 produced 7-, 8-, 10-, 11-, 13-, and 14-hydroperoxides of 16:3, as well as a significant amount of bis-allylic 9-hydroperoxide.	bis-allylic 9-hydroperoxide	113-140	linoleate 9S-lipoxygenase-4	Glycine max	0-12
20423074-0	2010	Impact of distal mutation on hydrogen transfer interface and substrate conformation in soybean lipoxygenase.	Hydrogen	29-37	linoleate 9S-lipoxygenase-4	Glycine max	95-107
20337784-0	2010	The novel ketoprofen amides--synthesis and biological evaluation as antioxidants, lipoxygenase inhibitors and cytostatic agents.	Ketoprofen	10-20	linoleate 9S-lipoxygenase-4	Glycine max	82-94
20337784-0	2010	The novel ketoprofen amides--synthesis and biological evaluation as antioxidants, lipoxygenase inhibitors and cytostatic agents.	Amides	21-27	linoleate 9S-lipoxygenase-4	Glycine max	82-94
20337784-1	2010	The novel amides of ketoprofen and its reduced derivatives (5a-f, 4a-n, 6a-g) with aromatic and cycloalkyl amines or hydroxylamines were prepared and screened for their reducing and cytostatic activity as well as for their ability to inhibit soybean lipoxygenase and lipid peroxidation.	Amides	10-16	linoleate 9S-lipoxygenase-4	Glycine max	250-262
20337784-1	2010	The novel amides of ketoprofen and its reduced derivatives (5a-f, 4a-n, 6a-g) with aromatic and cycloalkyl amines or hydroxylamines were prepared and screened for their reducing and cytostatic activity as well as for their ability to inhibit soybean lipoxygenase and lipid peroxidation.	Ketoprofen	20-30	linoleate 9S-lipoxygenase-4	Glycine max	250-262
20337784-6	2010	Aromatic and cycloalkyl amides 4 and 5 were more potent lipoxygenase inhibitors than derivatives with carboxylic group.	aromatic and cycloalkyl amides	0-30	linoleate 9S-lipoxygenase-4	Glycine max	56-68
19679328-0	2009	Diethanolamine Pd(II) complexes in bioorganic modeling as model systems of metallopeptidases and soybean lipoxygenase inhibitors.	diethanolamine	0-14	linoleate 9S-lipoxygenase-4	Glycine max	105-117
20378968-0	2010	Soybean lipoxygenase inhibitory and DPPH radical-scavenging activities of aspernolide A and butyrolactones I and II.	aspernolide A	74-87	linoleate 9S-lipoxygenase-4	Glycine max	8-20
20378968-0	2010	Soybean lipoxygenase inhibitory and DPPH radical-scavenging activities of aspernolide A and butyrolactones I and II.	4-Butyrolactone	92-106	linoleate 9S-lipoxygenase-4	Glycine max	8-20
20378968-1	2010	Aspernolide A and butyrolactones I and II showed inhibitory activities against soybean lipoxygenase.	aspernolide A	0-13	linoleate 9S-lipoxygenase-4	Glycine max	87-99
20378968-1	2010	Aspernolide A and butyrolactones I and II showed inhibitory activities against soybean lipoxygenase.	4-Butyrolactone	18-32	linoleate 9S-lipoxygenase-4	Glycine max	87-99
20184028-0	2010	Lipoxygenase inhibitory activity of 6-pentadecanylsalicylic acid without prooxidant effect.	6-pentadecanylsalicylic acid	36-64	linoleate 9S-lipoxygenase-4	Glycine max	0-12
19853459-0	2009	Natural and synthetic 2"-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity.	2'-hydroxychalcone	22-42	linoleate 9S-lipoxygenase-4	Glycine max	130-142
19912068-0	2009	Trioxsalen derivatives with lipoxygenase inhibitory activity.	Trioxsalen	0-10	linoleate 9S-lipoxygenase-4	Glycine max	28-40
19679328-0	2009	Diethanolamine Pd(II) complexes in bioorganic modeling as model systems of metallopeptidases and soybean lipoxygenase inhibitors.	Polydioxanone	15-21	linoleate 9S-lipoxygenase-4	Glycine max	105-117
19825592-6	2008	Proteomic analysis of the isolated oil bodies of the 24-kDa oleosin knockdown shows the absence of the 24-kDa oleosin and the presence of abundant caleosin and lipoxygenase.	Oils	35-38	linoleate 9S-lipoxygenase-4	Glycine max	147-172
19772491-0	2009	Kukoamine A analogs with lipoxygenase inhibitory activity.	kukoamine A	0-11	linoleate 9S-lipoxygenase-4	Glycine max	25-37
19560532-0	2009	Antioxidant and lipoxygenase inhibitory activity of oligostilbenes from the leaf and stem of Vitis amurensis.	oligostilbenes	52-66	linoleate 9S-lipoxygenase-4	Glycine max	16-28
19560532-10	2009	Of the isolates, r-2-viniferin (8) exhibited the strongest scavenging activity against ABTS(+) radical with TEAC value of 5.57, and the most potential inhibitory effect on soybean lipoxygenase with the IC(50) value of 6.39 microM.	r2-viniferin	17-30	linoleate 9S-lipoxygenase-4	Glycine max	180-192
19825592-6	2008	Proteomic analysis of the isolated oil bodies of the 24-kDa oleosin knockdown shows the absence of the 24-kDa oleosin and the presence of abundant caleosin and lipoxygenase.	oleosin	60-67	linoleate 9S-lipoxygenase-4	Glycine max	147-172
18067328-0	2008	Secondary alkyl hydroperoxides as inhibitors and alternate substrates for lipoxygenase.	alkyl hydroperoxides	10-30	linoleate 9S-lipoxygenase-4	Glycine max	74-86
18247539-1	2008	Oxygenation of arachidonoyl lysophosphatidylcholine (lysoPC) or arachidonoyl lysophosphatidic acid (lysoPA) by lipoxygenase (LOX) was examined.	arachidonoyl lysophosphatidylcholine	15-51	linoleate 9S-lipoxygenase-4	Glycine max	111-123
18247539-1	2008	Oxygenation of arachidonoyl lysophosphatidylcholine (lysoPC) or arachidonoyl lysophosphatidic acid (lysoPA) by lipoxygenase (LOX) was examined.	arachidonoyl lysophosphatidylcholine	15-51	linoleate 9S-lipoxygenase-4	Glycine max	125-128
18247539-1	2008	Oxygenation of arachidonoyl lysophosphatidylcholine (lysoPC) or arachidonoyl lysophosphatidic acid (lysoPA) by lipoxygenase (LOX) was examined.	arachidonoyl lysophosphatidic acid	64-98	linoleate 9S-lipoxygenase-4	Glycine max	111-123
18247539-1	2008	Oxygenation of arachidonoyl lysophosphatidylcholine (lysoPC) or arachidonoyl lysophosphatidic acid (lysoPA) by lipoxygenase (LOX) was examined.	arachidonoyl lysophosphatidic acid	64-98	linoleate 9S-lipoxygenase-4	Glycine max	125-128
18247539-1	2008	Oxygenation of arachidonoyl lysophosphatidylcholine (lysoPC) or arachidonoyl lysophosphatidic acid (lysoPA) by lipoxygenase (LOX) was examined.	lysophosphatidic acid	100-106	linoleate 9S-lipoxygenase-4	Glycine max	111-123
18247539-1	2008	Oxygenation of arachidonoyl lysophosphatidylcholine (lysoPC) or arachidonoyl lysophosphatidic acid (lysoPA) by lipoxygenase (LOX) was examined.	lysophosphatidic acid	100-106	linoleate 9S-lipoxygenase-4	Glycine max	125-128
18247539-3	2008	Straight-phase and chiral-phase HPLC analyses indicated that soybean LOX-1 and rabbit reticulocyte LOX oxygenated arachidonoyl lysophospholipids mainly at C-15 with the S form as major enantiomer, whereas porcine leukocyte LOX oxygenated at C-12 with the S form.	arachidonoyl lysophospholipids	114-144	linoleate 9S-lipoxygenase-4	Glycine max	69-72
18247539-3	2008	Straight-phase and chiral-phase HPLC analyses indicated that soybean LOX-1 and rabbit reticulocyte LOX oxygenated arachidonoyl lysophospholipids mainly at C-15 with the S form as major enantiomer, whereas porcine leukocyte LOX oxygenated at C-12 with the S form.	arachidonoyl lysophospholipids	114-144	linoleate 9S-lipoxygenase-4	Glycine max	99-102
18247539-3	2008	Straight-phase and chiral-phase HPLC analyses indicated that soybean LOX-1 and rabbit reticulocyte LOX oxygenated arachidonoyl lysophospholipids mainly at C-15 with the S form as major enantiomer, whereas porcine leukocyte LOX oxygenated at C-12 with the S form.	arachidonoyl lysophospholipids	114-144	linoleate 9S-lipoxygenase-4	Glycine max	99-102
18247539-4	2008	Next, the sequential exposure of arachidonoyl-lysoPC to soybean LOX-1 and porcine leukocyte LOX afforded two major isomers of dihydroxy derivatives with conjugated triene structure, suggesting that 15(S)-hydroperoxyeicosatetraenoyl derivatives were converted to 8,15(S)-dihydroxyeicosatetraenoyl derivatives.	arachidonoyl-lysopc	33-52	linoleate 9S-lipoxygenase-4	Glycine max	64-67
18247539-4	2008	Next, the sequential exposure of arachidonoyl-lysoPC to soybean LOX-1 and porcine leukocyte LOX afforded two major isomers of dihydroxy derivatives with conjugated triene structure, suggesting that 15(S)-hydroperoxyeicosatetraenoyl derivatives were converted to 8,15(S)-dihydroxyeicosatetraenoyl derivatives.	arachidonoyl-lysopc	33-52	linoleate 9S-lipoxygenase-4	Glycine max	92-95
18247539-4	2008	Next, the sequential exposure of arachidonoyl-lysoPC to soybean LOX-1 and porcine leukocyte LOX afforded two major isomers of dihydroxy derivatives with conjugated triene structure, suggesting that 15(S)-hydroperoxyeicosatetraenoyl derivatives were converted to 8,15(S)-dihydroxyeicosatetraenoyl derivatives.	TRIETHYLENETETRAMINE	164-170	linoleate 9S-lipoxygenase-4	Glycine max	64-67
18247539-4	2008	Next, the sequential exposure of arachidonoyl-lysoPC to soybean LOX-1 and porcine leukocyte LOX afforded two major isomers of dihydroxy derivatives with conjugated triene structure, suggesting that 15(S)-hydroperoxyeicosatetraenoyl derivatives were converted to 8,15(S)-dihydroxyeicosatetraenoyl derivatives.	TRIETHYLENETETRAMINE	164-170	linoleate 9S-lipoxygenase-4	Glycine max	92-95
18247539-4	2008	Next, the sequential exposure of arachidonoyl-lysoPC to soybean LOX-1 and porcine leukocyte LOX afforded two major isomers of dihydroxy derivatives with conjugated triene structure, suggesting that 15(S)-hydroperoxyeicosatetraenoyl derivatives were converted to 8,15(S)-dihydroxyeicosatetraenoyl derivatives.	(s)-hydroperoxyeicosatetraenoyl derivatives	200-243	linoleate 9S-lipoxygenase-4	Glycine max	64-67
18247539-4	2008	Next, the sequential exposure of arachidonoyl-lysoPC to soybean LOX-1 and porcine leukocyte LOX afforded two major isomers of dihydroxy derivatives with conjugated triene structure, suggesting that 15(S)-hydroperoxyeicosatetraenoyl derivatives were converted to 8,15(S)-dihydroxyeicosatetraenoyl derivatives.	(s)-hydroperoxyeicosatetraenoyl derivatives	200-243	linoleate 9S-lipoxygenase-4	Glycine max	92-95
18247539-4	2008	Next, the sequential exposure of arachidonoyl-lysoPC to soybean LOX-1 and porcine leukocyte LOX afforded two major isomers of dihydroxy derivatives with conjugated triene structure, suggesting that 15(S)-hydroperoxyeicosatetraenoyl derivatives were converted to 8,15(S)-dihydroxyeicosatetraenoyl derivatives.	8,15(s)-dihydroxyeicosatetraenoyl derivatives	262-307	linoleate 9S-lipoxygenase-4	Glycine max	64-67
18247539-4	2008	Next, the sequential exposure of arachidonoyl-lysoPC to soybean LOX-1 and porcine leukocyte LOX afforded two major isomers of dihydroxy derivatives with conjugated triene structure, suggesting that 15(S)-hydroperoxyeicosatetraenoyl derivatives were converted to 8,15(S)-dihydroxyeicosatetraenoyl derivatives.	8,15(s)-dihydroxyeicosatetraenoyl derivatives	262-307	linoleate 9S-lipoxygenase-4	Glycine max	92-95
18247539-5	2008	Separately, arachidonoyl-lysoPA, but not arachidonoyl-lysoPC, was found to be susceptible to double oxygenation by soybean LOX-1 to generate a dihydroperoxyeicosatetraenoyl derivative.	arachidonoyl-lysopa	12-31	linoleate 9S-lipoxygenase-4	Glycine max	123-126
18247539-5	2008	Separately, arachidonoyl-lysoPA, but not arachidonoyl-lysoPC, was found to be susceptible to double oxygenation by soybean LOX-1 to generate a dihydroperoxyeicosatetraenoyl derivative.	dihydroperoxyeicosatetraenoyl	143-172	linoleate 9S-lipoxygenase-4	Glycine max	123-126
18247539-6	2008	Overall, arachidonoyl lysophospholipids were more efficient than arachidonic acid as LOX substrate.	arachidonoyl lysophospholipids	9-39	linoleate 9S-lipoxygenase-4	Glycine max	85-88
18247539-6	2008	Overall, arachidonoyl lysophospholipids were more efficient than arachidonic acid as LOX substrate.	Arachidonic Acid	65-81	linoleate 9S-lipoxygenase-4	Glycine max	85-88
18680379-0	2008	Regulation of lipoxygenase activity by polyunsaturated lysophosphatidylcholines or their oxygenation derivatives.	polyunsaturated lysophosphatidylcholines	39-79	linoleate 9S-lipoxygenase-4	Glycine max	14-26
18067328-1	2008	Lipoxygenase plays a central role in polyunsaturated fatty acid metabolism, inaugurating the biosynthesis of eicosanoids in animals and phytooxylipins in plants.	Fatty Acids, Unsaturated	37-63	linoleate 9S-lipoxygenase-4	Glycine max	0-12
18067328-1	2008	Lipoxygenase plays a central role in polyunsaturated fatty acid metabolism, inaugurating the biosynthesis of eicosanoids in animals and phytooxylipins in plants.	Eicosanoids	109-120	linoleate 9S-lipoxygenase-4	Glycine max	0-12
18067328-1	2008	Lipoxygenase plays a central role in polyunsaturated fatty acid metabolism, inaugurating the biosynthesis of eicosanoids in animals and phytooxylipins in plants.	phytooxylipins	136-150	linoleate 9S-lipoxygenase-4	Glycine max	0-12
18067328-4	2008	Controlling the redox state of lipoxygenase iron with small molecules, inhibitors or activators, could be a means to modulate the activity of the enzyme.	Iron	44-48	linoleate 9S-lipoxygenase-4	Glycine max	31-43
18067328-5	2008	The effects of secondary alkyl hydroperoxides and the corresponding alcohols on soybean lipoxygenase-1 reaction rates were investigated and found to be very different.	alkyl hydroperoxides	25-45	linoleate 9S-lipoxygenase-4	Glycine max	88-100
18067328-5	2008	The effects of secondary alkyl hydroperoxides and the corresponding alcohols on soybean lipoxygenase-1 reaction rates were investigated and found to be very different.	Alcohols	68-76	linoleate 9S-lipoxygenase-4	Glycine max	88-100
18067328-7	2008	Secondary alkyl hydroperoxides were inhibitors of lipoxygenase-1 primarily at high substrate concentration.	alkyl hydroperoxides	10-30	linoleate 9S-lipoxygenase-4	Glycine max	50-62
18067328-10	2008	Oxidation of the iron in lipoxygenase-1 by 2-hydroperoxyalkanes was evident in electron paramagnetic resonance (EPR) measurements, but the enzyme was neither activated nor was it inactivated.	Iron	17-21	linoleate 9S-lipoxygenase-4	Glycine max	25-37
18067328-10	2008	Oxidation of the iron in lipoxygenase-1 by 2-hydroperoxyalkanes was evident in electron paramagnetic resonance (EPR) measurements, but the enzyme was neither activated nor was it inactivated.	2-hydroperoxyalkanes	43-63	linoleate 9S-lipoxygenase-4	Glycine max	25-37
17996330-0	2007	Improvement of lipoxygenase inhibition by octapeptides.	octapeptides	42-54	linoleate 9S-lipoxygenase-4	Glycine max	15-27
17996330-4	2007	Replacement of the negatively charged glutamic acid by any other amino acid residue improves LOX binding.	Glutamic Acid	38-51	linoleate 9S-lipoxygenase-4	Glycine max	93-96
17897068-0	2007	Heterocyclic aryl(phenyl)acetic Acid and aryl acetohydroxamic acids as antiinflammatory -antioxidant agents and inhibitors of lipoxygenase and serine proteases.	aryl acetohydroxamic acids	41-67	linoleate 9S-lipoxygenase-4	Glycine max	126-138
17604175-0	2007	Synthesis and pharmacochemical evaluation of novel aryl-acetic acid inhibitors of lipoxygenase, antioxidants, and anti-inflammatory agents.	aryl-acetic acid	51-67	linoleate 9S-lipoxygenase-4	Glycine max	82-94
17604175-1	2007	Lipoxygenase catalyzes the first two steps of the transformation of arachidonic acid into leukotrienes which are implicated in host defense reactions.	Arachidonic Acid	68-84	linoleate 9S-lipoxygenase-4	Glycine max	0-12
17604175-1	2007	Lipoxygenase catalyzes the first two steps of the transformation of arachidonic acid into leukotrienes which are implicated in host defense reactions.	Leukotrienes	90-102	linoleate 9S-lipoxygenase-4	Glycine max	0-12
17604175-3	2007	Taking into account that compounds bearing a thienyl, naphthyl, pyrollyl, and 2,4-di-tert-butyl-phenol moieties possess anti-inflammatory activity which is related to their capacity to transfer electrons and to scavenge reactive oxygen species, we synthesized some new aryl-acetic acids and we explored their ability to inhibit soybean lipoxygenase, to present antioxidant and anti-inflammatory activities, and to interact with glutathione.	thienyl	45-52	linoleate 9S-lipoxygenase-4	Glycine max	336-348
17897068-0	2007	Heterocyclic aryl(phenyl)acetic Acid and aryl acetohydroxamic acids as antiinflammatory -antioxidant agents and inhibitors of lipoxygenase and serine proteases.	aryl(phenyl)acetic acid	13-36	linoleate 9S-lipoxygenase-4	Glycine max	126-138
17897068-1	2007	Taking into account that compounds bearing a thiazolyl, pyridyl and indolyl, moieties possess a wide spectrum of biological activities which is related to their capacity to transfer electrons and to scavenge reactive oxygen species (ROS), we synthesized some new heterocyclic aryl acetic acids and the corresponding acetohydroxamic acids and we explored their ability to inhibit soybean lipoxygenase, to present antioxidant and anti-inflammatory activities as well as to present serine proteases inhibition.	thiazolyl	45-54	linoleate 9S-lipoxygenase-4	Glycine max	387-399
17897068-1	2007	Taking into account that compounds bearing a thiazolyl, pyridyl and indolyl, moieties possess a wide spectrum of biological activities which is related to their capacity to transfer electrons and to scavenge reactive oxygen species (ROS), we synthesized some new heterocyclic aryl acetic acids and the corresponding acetohydroxamic acids and we explored their ability to inhibit soybean lipoxygenase, to present antioxidant and anti-inflammatory activities as well as to present serine proteases inhibition.	indolyl	68-75	linoleate 9S-lipoxygenase-4	Glycine max	387-399
17897068-1	2007	Taking into account that compounds bearing a thiazolyl, pyridyl and indolyl, moieties possess a wide spectrum of biological activities which is related to their capacity to transfer electrons and to scavenge reactive oxygen species (ROS), we synthesized some new heterocyclic aryl acetic acids and the corresponding acetohydroxamic acids and we explored their ability to inhibit soybean lipoxygenase, to present antioxidant and anti-inflammatory activities as well as to present serine proteases inhibition.	Reactive Oxygen Species	233-236	linoleate 9S-lipoxygenase-4	Glycine max	387-399
17227895-0	2007	Intramolecular rearrangement of linolenate peroxyl radicals in lipoxygenase reactions at lower oxygen content.	linolenate peroxyl radicals	32-59	linoleate 9S-lipoxygenase-4	Glycine max	63-75
17227895-7	2007	We proposed a possible reaction pathway as follows: a linolenate 9-peroxyl radical generated in the lipoxygenase reaction might be converted into C(2)H(5)-.CH-CH = CH-CH = CH-CH = CH-CH(OOH) -C(7)H(14)-COOH through an intramolecular rearrangement.	linolenate 9-peroxyl radical	54-82	linoleate 9S-lipoxygenase-4	Glycine max	100-112
17227895-7	2007	We proposed a possible reaction pathway as follows: a linolenate 9-peroxyl radical generated in the lipoxygenase reaction might be converted into C(2)H(5)-.CH-CH = CH-CH = CH-CH = CH-CH(OOH) -C(7)H(14)-COOH through an intramolecular rearrangement.	c(2)h	146-151	linoleate 9S-lipoxygenase-4	Glycine max	100-112
17348855-0	2007	Synthesis of phenyl-substituted amides with antioxidant and anti-inflammatory activity as novel lipoxygenase inhibitors.	phenyl-substituted amides	13-38	linoleate 9S-lipoxygenase-4	Glycine max	96-108
16933093-0	2006	Continuous measurement of the lipoxygenase-catalyzed oxidation of unsaturated lipids using the monomolecular film technique.	unsaturated lipids	66-84	linoleate 9S-lipoxygenase-4	Glycine max	30-42
17176111-1	2006	Soybean lipoxygenase-1 (SBLO-1) catalyzes the oxygenation of polyunsaturated fatty acids to produce conjugated diene hydroperoxides.	Fatty Acids, Unsaturated	61-88	linoleate 9S-lipoxygenase-4	Glycine max	8-20
17176111-1	2006	Soybean lipoxygenase-1 (SBLO-1) catalyzes the oxygenation of polyunsaturated fatty acids to produce conjugated diene hydroperoxides.	diene hydroperoxides	111-131	linoleate 9S-lipoxygenase-4	Glycine max	8-20
17176111-3	2006	(2001) Soybean Lipoxygenase-Mediated Oxygenation of Monounsaturated Fatty Acids to Enones, J.	Fatty Acids, Monounsaturated	52-79	linoleate 9S-lipoxygenase-4	Glycine max	15-27
17176111-3	2006	(2001) Soybean Lipoxygenase-Mediated Oxygenation of Monounsaturated Fatty Acids to Enones, J.	enones	83-89	linoleate 9S-lipoxygenase-4	Glycine max	15-27
17176111-13	2006	Comparison of the activities of 9(Z)-octadecenoic acid and 12(Z)-octadecenoic acid implies that the two double bonds of linoleic acid contribute almost equally to the C-H bond-breaking step in the normal lipoxygenase reaction.	Oleic Acid	32-54	linoleate 9S-lipoxygenase-4	Glycine max	204-216
17176111-13	2006	Comparison of the activities of 9(Z)-octadecenoic acid and 12(Z)-octadecenoic acid implies that the two double bonds of linoleic acid contribute almost equally to the C-H bond-breaking step in the normal lipoxygenase reaction.	12(z)-octadecenoic acid	59-82	linoleate 9S-lipoxygenase-4	Glycine max	204-216
17176111-13	2006	Comparison of the activities of 9(Z)-octadecenoic acid and 12(Z)-octadecenoic acid implies that the two double bonds of linoleic acid contribute almost equally to the C-H bond-breaking step in the normal lipoxygenase reaction.	Linoleic Acid	120-133	linoleate 9S-lipoxygenase-4	Glycine max	204-216
17061812-1	2006	The capacity of polyphenolic compounds to reduce the beta-carotene-linoleic acid cooxidation enzymatically induced by soybean lipoxygenase was assayed to determine their comprehensive antioxidant ability.	beta Carotene	53-66	linoleate 9S-lipoxygenase-4	Glycine max	126-138
17373554-4	2007	Among the examined compounds, lithospermic acid B demonstrated the best inhibitory activity on soybean lipoxygenase with IC50 = 0.1 mM.	lithospermic acid B	30-49	linoleate 9S-lipoxygenase-4	Glycine max	103-115
18256725-0	2007	Organosilicon-containing thiazole derivatives as potential lipoxygenase inhibitors and anti-inflammatory agents.	Thiazoles	25-33	linoleate 9S-lipoxygenase-4	Glycine max	59-71
18256725-4	2007	2-(4-Trimethylsilyloxypiperidin-1-yl)-N-[4-(p-methoxyphenyl)-thiazol-2-yl]-acetamide (19) was the most potent displaying inhibition against lipoxygenase (ID(50) = 0.01 mmol).	2-(4-trimethylsilyloxypiperidin-1-yl)-n-[4-(p-methoxyphenyl)-thiazol-2-yl]-acetamide	0-84	linoleate 9S-lipoxygenase-4	Glycine max	140-152
17029406-9	2006	The stearate spin-labeled at C5 has the highest affinity for the lipoxygenase, and it is a competitive inhibitor, with a K(i) of 9 muM.	Stearates	4-12	linoleate 9S-lipoxygenase-4	Glycine max	65-77
16873120-2	2006	An alternate model for tunnelling emerged following studies of the hydrogen atom transfer catalysed by the enzyme soybean lipoxygenase.	Hydrogen	67-75	linoleate 9S-lipoxygenase-4	Glycine max	122-134
16815818-0	2006	The effects of natural flavonoids on lipoxygenase-mediated oxidation of compounds with a benzene ring structure--a new possible mechanism of flavonoid anti-chemical carcinogenesis and other toxicities.	Flavonoids	23-33	linoleate 9S-lipoxygenase-4	Glycine max	37-49
16815818-0	2006	The effects of natural flavonoids on lipoxygenase-mediated oxidation of compounds with a benzene ring structure--a new possible mechanism of flavonoid anti-chemical carcinogenesis and other toxicities.	Benzene	89-96	linoleate 9S-lipoxygenase-4	Glycine max	37-49
16815818-0	2006	The effects of natural flavonoids on lipoxygenase-mediated oxidation of compounds with a benzene ring structure--a new possible mechanism of flavonoid anti-chemical carcinogenesis and other toxicities.	Flavonoids	23-32	linoleate 9S-lipoxygenase-4	Glycine max	37-49
16815818-2	2006	In this study, the effect of natural flavonoid compounds, such as green tea polyphenol, epigallocatechin gallate, quercetin, and rutin on lipoxygenase-mediated co-oxidation of guaiacol, benzidine, paraphenylenediamine, and dimethoxybenzidine was investigated.	Flavonoids	37-46	linoleate 9S-lipoxygenase-4	Glycine max	138-150
16542568-2	2006	The Fourier transform infrared (FT-IR) spectra of the enzyme obtained in chloroform, methanol, and acetonitrile showed an absorption band at 1617 cm(-1) indicative of significant protein aggregation, whereas spectra of lipoxygenase in hexane and octane exhibited substantially less aggregate formation.	Chloroform	73-83	linoleate 9S-lipoxygenase-4	Glycine max	219-231
16815818-2	2006	In this study, the effect of natural flavonoid compounds, such as green tea polyphenol, epigallocatechin gallate, quercetin, and rutin on lipoxygenase-mediated co-oxidation of guaiacol, benzidine, paraphenylenediamine, and dimethoxybenzidine was investigated.	Polyphenols	76-86	linoleate 9S-lipoxygenase-4	Glycine max	138-150
16815818-2	2006	In this study, the effect of natural flavonoid compounds, such as green tea polyphenol, epigallocatechin gallate, quercetin, and rutin on lipoxygenase-mediated co-oxidation of guaiacol, benzidine, paraphenylenediamine, and dimethoxybenzidine was investigated.	epigallocatechin gallate	88-112	linoleate 9S-lipoxygenase-4	Glycine max	138-150
16815818-2	2006	In this study, the effect of natural flavonoid compounds, such as green tea polyphenol, epigallocatechin gallate, quercetin, and rutin on lipoxygenase-mediated co-oxidation of guaiacol, benzidine, paraphenylenediamine, and dimethoxybenzidine was investigated.	Quercetin	114-123	linoleate 9S-lipoxygenase-4	Glycine max	138-150
16815818-2	2006	In this study, the effect of natural flavonoid compounds, such as green tea polyphenol, epigallocatechin gallate, quercetin, and rutin on lipoxygenase-mediated co-oxidation of guaiacol, benzidine, paraphenylenediamine, and dimethoxybenzidine was investigated.	Rutin	129-134	linoleate 9S-lipoxygenase-4	Glycine max	138-150
16815818-2	2006	In this study, the effect of natural flavonoid compounds, such as green tea polyphenol, epigallocatechin gallate, quercetin, and rutin on lipoxygenase-mediated co-oxidation of guaiacol, benzidine, paraphenylenediamine, and dimethoxybenzidine was investigated.	Guaiacol	176-184	linoleate 9S-lipoxygenase-4	Glycine max	138-150
16815818-2	2006	In this study, the effect of natural flavonoid compounds, such as green tea polyphenol, epigallocatechin gallate, quercetin, and rutin on lipoxygenase-mediated co-oxidation of guaiacol, benzidine, paraphenylenediamine, and dimethoxybenzidine was investigated.	benzidine	186-195	linoleate 9S-lipoxygenase-4	Glycine max	138-150
16815818-2	2006	In this study, the effect of natural flavonoid compounds, such as green tea polyphenol, epigallocatechin gallate, quercetin, and rutin on lipoxygenase-mediated co-oxidation of guaiacol, benzidine, paraphenylenediamine, and dimethoxybenzidine was investigated.	4-phenylenediamine	197-217	linoleate 9S-lipoxygenase-4	Glycine max	138-150
16815818-2	2006	In this study, the effect of natural flavonoid compounds, such as green tea polyphenol, epigallocatechin gallate, quercetin, and rutin on lipoxygenase-mediated co-oxidation of guaiacol, benzidine, paraphenylenediamine, and dimethoxybenzidine was investigated.	Dimethoxybenzidine	223-241	linoleate 9S-lipoxygenase-4	Glycine max	138-150
16815818-3	2006	Green tea polyphenol, epigallocatechin gallate, quercetin, and rutin can reduce the co-oxidation reaction speed of tested compounds mediated by soybean lipoxygenase and the production of oxidative products and free radical intermediates.	Polyphenols	10-20	linoleate 9S-lipoxygenase-4	Glycine max	152-164
16815818-3	2006	Green tea polyphenol, epigallocatechin gallate, quercetin, and rutin can reduce the co-oxidation reaction speed of tested compounds mediated by soybean lipoxygenase and the production of oxidative products and free radical intermediates.	epigallocatechin gallate	22-46	linoleate 9S-lipoxygenase-4	Glycine max	152-164
16815818-3	2006	Green tea polyphenol, epigallocatechin gallate, quercetin, and rutin can reduce the co-oxidation reaction speed of tested compounds mediated by soybean lipoxygenase and the production of oxidative products and free radical intermediates.	Quercetin	48-57	linoleate 9S-lipoxygenase-4	Glycine max	152-164
16815818-3	2006	Green tea polyphenol, epigallocatechin gallate, quercetin, and rutin can reduce the co-oxidation reaction speed of tested compounds mediated by soybean lipoxygenase and the production of oxidative products and free radical intermediates.	Rutin	63-68	linoleate 9S-lipoxygenase-4	Glycine max	152-164
16815818-4	2006	Their median inhibition concentrations on guaiacol oxidation mediated by soybean lipoxygenase were 8.22 mg.L-1, 17.8 micromol.L-1, 41.5 micromol.L-1, and 46.3 micromol.L-1, respectively.	Guaiacol	42-50	linoleate 9S-lipoxygenase-4	Glycine max	81-93
16391324-0	2006	A one-step method of 10,17-dihydro(pero)xydocosahexa-4Z,7Z,11E,13Z,15E,19Z-enoic acid synthesis by soybean lipoxygenase.	10,17-dihydro(pero)xydocosahexa-4z,7z	21-58	linoleate 9S-lipoxygenase-4	Glycine max	107-119
16391324-0	2006	A one-step method of 10,17-dihydro(pero)xydocosahexa-4Z,7Z,11E,13Z,15E,19Z-enoic acid synthesis by soybean lipoxygenase.	N-[(2-Amino-1,3-Benzothiazol-6-Yl)carbonyl]glycine	59-62	linoleate 9S-lipoxygenase-4	Glycine max	107-119
16391324-0	2006	A one-step method of 10,17-dihydro(pero)xydocosahexa-4Z,7Z,11E,13Z,15E,19Z-enoic acid synthesis by soybean lipoxygenase.	,19z-enoic acid	70-85	linoleate 9S-lipoxygenase-4	Glycine max	107-119
16948471-0	2006	Antioxidant and anti-inflammatory activity of aryl-acetic and hydroxamic acids as novel lipoxygenase inhibitors.	aryl-acetic and hydroxamic acids	46-78	linoleate 9S-lipoxygenase-4	Glycine max	88-100
16948471-1	2006	Lipoxygenase plays an essential role in the biosynthesis of the leukotrienes.	Leukotrienes	64-76	linoleate 9S-lipoxygenase-4	Glycine max	0-12
16948471-3	2006	Simple stable molecules containing the hydroxamic acid functionality have been shown to inhibit 5-lipoxygenase.	Hydroxamic Acids	39-54	linoleate 9S-lipoxygenase-4	Glycine max	98-110
16542568-2	2006	The Fourier transform infrared (FT-IR) spectra of the enzyme obtained in chloroform, methanol, and acetonitrile showed an absorption band at 1617 cm(-1) indicative of significant protein aggregation, whereas spectra of lipoxygenase in hexane and octane exhibited substantially less aggregate formation.	Methanol	85-93	linoleate 9S-lipoxygenase-4	Glycine max	219-231
16542568-2	2006	The Fourier transform infrared (FT-IR) spectra of the enzyme obtained in chloroform, methanol, and acetonitrile showed an absorption band at 1617 cm(-1) indicative of significant protein aggregation, whereas spectra of lipoxygenase in hexane and octane exhibited substantially less aggregate formation.	acetonitrile	99-111	linoleate 9S-lipoxygenase-4	Glycine max	219-231
16542568-4	2006	The secondary structure of lipoxygenase at the hexane-water interface was comparable to that of the structure of lipoxygenase in D(2)O after exposure of lipoxygenase solution to hexane.	Hexanes	47-53	linoleate 9S-lipoxygenase-4	Glycine max	27-39
16542568-4	2006	The secondary structure of lipoxygenase at the hexane-water interface was comparable to that of the structure of lipoxygenase in D(2)O after exposure of lipoxygenase solution to hexane.	Water	54-59	linoleate 9S-lipoxygenase-4	Glycine max	27-39
16542568-4	2006	The secondary structure of lipoxygenase at the hexane-water interface was comparable to that of the structure of lipoxygenase in D(2)O after exposure of lipoxygenase solution to hexane.	Hexanes	178-184	linoleate 9S-lipoxygenase-4	Glycine max	27-39
16542568-4	2006	The secondary structure of lipoxygenase at the hexane-water interface was comparable to that of the structure of lipoxygenase in D(2)O after exposure of lipoxygenase solution to hexane.	Hexanes	178-184	linoleate 9S-lipoxygenase-4	Glycine max	113-125
16542568-4	2006	The secondary structure of lipoxygenase at the hexane-water interface was comparable to that of the structure of lipoxygenase in D(2)O after exposure of lipoxygenase solution to hexane.	Hexanes	178-184	linoleate 9S-lipoxygenase-4	Glycine max	113-125
16186621-2	2005	The results showed that the highest immobilization efficiencies of LOX, 30.6 and 29.3%, were obtained with DEAE-cellulose and modified Eupergit C250L supports, respectively.	DEAE-Cellulose	107-121	linoleate 9S-lipoxygenase-4	Glycine max	67-70
21132078-0	2005	Modeling temperature dependent kinetic isotope effects for hydrogen transfer in a series of soybean lipoxygenase mutants: The effect of anharmonicity upon transfer distance.	Hydrogen	59-67	linoleate 9S-lipoxygenase-4	Glycine max	100-112
21132078-1	2005	Soybean lipoxygenase-1 (SLO) catalyzes the oxidation of linoleic acid.	Linoleic Acid	56-69	linoleate 9S-lipoxygenase-4	Glycine max	8-20
16157595-1	2005	Recent findings associate the control of stereochemistry in lipoxygenase (LOX) catalysis with a conserved active site alanine for S configuration hydroperoxide products, or a corresponding glycine for R stereoconfiguration.	Alanine	118-125	linoleate 9S-lipoxygenase-4	Glycine max	60-72
16157595-1	2005	Recent findings associate the control of stereochemistry in lipoxygenase (LOX) catalysis with a conserved active site alanine for S configuration hydroperoxide products, or a corresponding glycine for R stereoconfiguration.	Alanine	118-125	linoleate 9S-lipoxygenase-4	Glycine max	74-77
16157595-1	2005	Recent findings associate the control of stereochemistry in lipoxygenase (LOX) catalysis with a conserved active site alanine for S configuration hydroperoxide products, or a corresponding glycine for R stereoconfiguration.	Hydrogen Peroxide	146-159	linoleate 9S-lipoxygenase-4	Glycine max	60-72
16157595-1	2005	Recent findings associate the control of stereochemistry in lipoxygenase (LOX) catalysis with a conserved active site alanine for S configuration hydroperoxide products, or a corresponding glycine for R stereoconfiguration.	Hydrogen Peroxide	146-159	linoleate 9S-lipoxygenase-4	Glycine max	74-77
16157595-1	2005	Recent findings associate the control of stereochemistry in lipoxygenase (LOX) catalysis with a conserved active site alanine for S configuration hydroperoxide products, or a corresponding glycine for R stereoconfiguration.	Glycine	189-196	linoleate 9S-lipoxygenase-4	Glycine max	60-72
16157595-1	2005	Recent findings associate the control of stereochemistry in lipoxygenase (LOX) catalysis with a conserved active site alanine for S configuration hydroperoxide products, or a corresponding glycine for R stereoconfiguration.	Glycine	189-196	linoleate 9S-lipoxygenase-4	Glycine max	74-77
16157595-2	2005	To further elucidate the mechanistic basis for this stereocontrol we compared the stereoselectivity of the initiating hydrogen abstraction in soybean LOX-1 and an Ala542Gly mutant that converts linoleic acid to both 13S and 9R configuration hydroperoxide products.	Hydrogen	118-126	linoleate 9S-lipoxygenase-4	Glycine max	150-153
16157595-6	2005	To examine also the reversed orientation of substrate binding, we studied oxygenation of the 15S-hydroperoxide of arachidonic acid by the Ala542Gly mutant soybean LOX-1.	15s-hydroperoxide	93-110	linoleate 9S-lipoxygenase-4	Glycine max	163-166
16157595-6	2005	To examine also the reversed orientation of substrate binding, we studied oxygenation of the 15S-hydroperoxide of arachidonic acid by the Ala542Gly mutant soybean LOX-1.	Arachidonic Acid	114-130	linoleate 9S-lipoxygenase-4	Glycine max	163-166
16459928-9	2005	8,13-Dihydroperoxyoctadecatrienoic acid was synthesized by vitamin E-controlled autoxidation of gamma-linolenic acid followed by reaction with soybean lipoxygenase.	8,13-dihydroperoxyoctadecatrienoic acid	0-39	linoleate 9S-lipoxygenase-4	Glycine max	151-163
16459928-9	2005	8,13-Dihydroperoxyoctadecatrienoic acid was synthesized by vitamin E-controlled autoxidation of gamma-linolenic acid followed by reaction with soybean lipoxygenase.	Vitamin E	59-68	linoleate 9S-lipoxygenase-4	Glycine max	151-163
16186621-4	2005	The results showed a 1.5 and a 1.6 increase in the activity of free and immobilized LOXs, respectively, using a mixture of hexane and 1,4-dioxane compared with that in hexane alone; however, cosolvents, including 2-octanone, 2-heptanone, 2-butanone, and cyclohexanone, displayed an inhibitory effect on LOX activity.	Hexanes	123-129	linoleate 9S-lipoxygenase-4	Glycine max	84-87
16186621-4	2005	The results showed a 1.5 and a 1.6 increase in the activity of free and immobilized LOXs, respectively, using a mixture of hexane and 1,4-dioxane compared with that in hexane alone; however, cosolvents, including 2-octanone, 2-heptanone, 2-butanone, and cyclohexanone, displayed an inhibitory effect on LOX activity.	1,4-dioxane	134-145	linoleate 9S-lipoxygenase-4	Glycine max	84-87
16186621-4	2005	The results showed a 1.5 and a 1.6 increase in the activity of free and immobilized LOXs, respectively, using a mixture of hexane and 1,4-dioxane compared with that in hexane alone; however, cosolvents, including 2-octanone, 2-heptanone, 2-butanone, and cyclohexanone, displayed an inhibitory effect on LOX activity.	Hexanes	168-174	linoleate 9S-lipoxygenase-4	Glycine max	84-87
16186621-4	2005	The results showed a 1.5 and a 1.6 increase in the activity of free and immobilized LOXs, respectively, using a mixture of hexane and 1,4-dioxane compared with that in hexane alone; however, cosolvents, including 2-octanone, 2-heptanone, 2-butanone, and cyclohexanone, displayed an inhibitory effect on LOX activity.	2-octanone	213-223	linoleate 9S-lipoxygenase-4	Glycine max	84-87
16186621-4	2005	The results showed a 1.5 and a 1.6 increase in the activity of free and immobilized LOXs, respectively, using a mixture of hexane and 1,4-dioxane compared with that in hexane alone; however, cosolvents, including 2-octanone, 2-heptanone, 2-butanone, and cyclohexanone, displayed an inhibitory effect on LOX activity.	2-heptanone	225-236	linoleate 9S-lipoxygenase-4	Glycine max	84-87
16186621-4	2005	The results showed a 1.5 and a 1.6 increase in the activity of free and immobilized LOXs, respectively, using a mixture of hexane and 1,4-dioxane compared with that in hexane alone; however, cosolvents, including 2-octanone, 2-heptanone, 2-butanone, and cyclohexanone, displayed an inhibitory effect on LOX activity.	methylethyl ketone	238-248	linoleate 9S-lipoxygenase-4	Glycine max	84-87
16186621-4	2005	The results showed a 1.5 and a 1.6 increase in the activity of free and immobilized LOXs, respectively, using a mixture of hexane and 1,4-dioxane compared with that in hexane alone; however, cosolvents, including 2-octanone, 2-heptanone, 2-butanone, and cyclohexanone, displayed an inhibitory effect on LOX activity.	cyclohexanone	254-267	linoleate 9S-lipoxygenase-4	Glycine max	84-87
16186621-5	2005	In the mixture of 1,4-dioxane and hexane, LOX activity was dependent on the cosolvent concentration, which was increased with 1,4-dioxane up to 5% (v/v).	1,4-dioxane	18-29	linoleate 9S-lipoxygenase-4	Glycine max	42-45
16186621-5	2005	In the mixture of 1,4-dioxane and hexane, LOX activity was dependent on the cosolvent concentration, which was increased with 1,4-dioxane up to 5% (v/v).	Hexanes	34-40	linoleate 9S-lipoxygenase-4	Glycine max	42-45
16186621-5	2005	In the mixture of 1,4-dioxane and hexane, LOX activity was dependent on the cosolvent concentration, which was increased with 1,4-dioxane up to 5% (v/v).	1,4-dioxane	126-137	linoleate 9S-lipoxygenase-4	Glycine max	42-45
16104814-2	2005	Soybean lipoxygenase (LOX) isozyme LOX 3 was reported not only to produce less 13-hydroperoxides, precursors of C(6) aldehydes, but also to convert them to ketodiene products.	13-hydroperoxides	79-96	linoleate 9S-lipoxygenase-4	Glycine max	8-20
16104814-2	2005	Soybean lipoxygenase (LOX) isozyme LOX 3 was reported not only to produce less 13-hydroperoxides, precursors of C(6) aldehydes, but also to convert them to ketodiene products.	13-hydroperoxides	79-96	linoleate 9S-lipoxygenase-4	Glycine max	22-25
16104814-2	2005	Soybean lipoxygenase (LOX) isozyme LOX 3 was reported not only to produce less 13-hydroperoxides, precursors of C(6) aldehydes, but also to convert them to ketodiene products.	n-hexanal	112-126	linoleate 9S-lipoxygenase-4	Glycine max	8-20
16104814-2	2005	Soybean lipoxygenase (LOX) isozyme LOX 3 was reported not only to produce less 13-hydroperoxides, precursors of C(6) aldehydes, but also to convert them to ketodiene products.	n-hexanal	112-126	linoleate 9S-lipoxygenase-4	Glycine max	22-25
16104814-2	2005	Soybean lipoxygenase (LOX) isozyme LOX 3 was reported not only to produce less 13-hydroperoxides, precursors of C(6) aldehydes, but also to convert them to ketodiene products.	ketodiene	156-165	linoleate 9S-lipoxygenase-4	Glycine max	8-20
16104814-2	2005	Soybean lipoxygenase (LOX) isozyme LOX 3 was reported not only to produce less 13-hydroperoxides, precursors of C(6) aldehydes, but also to convert them to ketodiene products.	ketodiene	156-165	linoleate 9S-lipoxygenase-4	Glycine max	22-25
16104814-3	2005	Here, we examined the effects of LOX 3 on hexenal formation from linolenic acid homogenized with watermelon 13-hydroperoxide lyase (HL)-overexpressing Nicotiana tabacum leaves and soybean acetone powder.	Hexobarbital	42-49	linoleate 9S-lipoxygenase-4	Glycine max	33-36
16104814-3	2005	Here, we examined the effects of LOX 3 on hexenal formation from linolenic acid homogenized with watermelon 13-hydroperoxide lyase (HL)-overexpressing Nicotiana tabacum leaves and soybean acetone powder.	alpha-Linolenic Acid	65-79	linoleate 9S-lipoxygenase-4	Glycine max	33-36
16104814-4	2005	Compared to the wild type, which contains LOXs 1, 2, and 3, the elimination of LOX 3 in LOX 1 + 2 facilitates greater production of hexenals.	Hexobarbital	132-140	linoleate 9S-lipoxygenase-4	Glycine max	42-45
16104814-5	2005	The use of LOX 2 alone yielded the highest hexenal production, while a two-step conversion was required for LOX 1 to produce hexenals at high levels due to different pH optima of the enzymes involved.	Hexobarbital	43-50	linoleate 9S-lipoxygenase-4	Glycine max	11-14
16104814-5	2005	The use of LOX 2 alone yielded the highest hexenal production, while a two-step conversion was required for LOX 1 to produce hexenals at high levels due to different pH optima of the enzymes involved.	Hexobarbital	125-133	linoleate 9S-lipoxygenase-4	Glycine max	11-14
15664304-0	2005	Effect of Cleome arabica leaf extract, rutin and quercetin on soybean lipoxygenase activity and on generation of inflammatory eicosanoids by human neutrophils.	Quercetin	49-58	linoleate 9S-lipoxygenase-4	Glycine max	70-82
15941315-3	2005	Twenty-one compounds, including 11 aldehydes, three alcohols, four ketones, one furan, one alkane, and one alkene were detected in the LOX normal soybean line.	Alkanes	91-97	linoleate 9S-lipoxygenase-4	Glycine max	135-138
15941315-3	2005	Twenty-one compounds, including 11 aldehydes, three alcohols, four ketones, one furan, one alkane, and one alkene were detected in the LOX normal soybean line.	Alkenes	107-113	linoleate 9S-lipoxygenase-4	Glycine max	135-138
15941315-5	2005	The antifungal aldehydes hexanal and (E)-2-hexenal were observed in both LOX normal and LOX deficient lines and were detected at significantly higher amounts in soybean homogenate with added lipase.	Aldehydes	15-24	linoleate 9S-lipoxygenase-4	Glycine max	73-76
15941315-5	2005	The antifungal aldehydes hexanal and (E)-2-hexenal were observed in both LOX normal and LOX deficient lines and were detected at significantly higher amounts in soybean homogenate with added lipase.	Aldehydes	15-24	linoleate 9S-lipoxygenase-4	Glycine max	88-91
15941315-5	2005	The antifungal aldehydes hexanal and (E)-2-hexenal were observed in both LOX normal and LOX deficient lines and were detected at significantly higher amounts in soybean homogenate with added lipase.	2-hexenal	37-50	linoleate 9S-lipoxygenase-4	Glycine max	73-76
15941315-5	2005	The antifungal aldehydes hexanal and (E)-2-hexenal were observed in both LOX normal and LOX deficient lines and were detected at significantly higher amounts in soybean homogenate with added lipase.	2-hexenal	37-50	linoleate 9S-lipoxygenase-4	Glycine max	88-91
15941315-6	2005	These aldehydes may be formed through alternate pathways, other than the LOX pathway, and may account for the inhibition of A. flavus growth observed.	Aldehydes	6-15	linoleate 9S-lipoxygenase-4	Glycine max	73-76
15941315-7	2005	Other volatiles detected, particularly the ketones and alcohols, may contribute to the antifungal activity observed in both LOX normal and LOX deficient soybean lines.	Ketones	43-50	linoleate 9S-lipoxygenase-4	Glycine max	124-127
15941315-7	2005	Other volatiles detected, particularly the ketones and alcohols, may contribute to the antifungal activity observed in both LOX normal and LOX deficient soybean lines.	Alcohols	55-63	linoleate 9S-lipoxygenase-4	Glycine max	124-127
15941315-7	2005	Other volatiles detected, particularly the ketones and alcohols, may contribute to the antifungal activity observed in both LOX normal and LOX deficient soybean lines.	Alcohols	55-63	linoleate 9S-lipoxygenase-4	Glycine max	139-142
15913294-0	2005	Lipoxygenase inhibitory activity of anacardic acids.	Anacardic Acids	36-51	linoleate 9S-lipoxygenase-4	Glycine max	0-12
15796576-8	2005	The results showed that 0.1% procyanidins have a strong antioxidant activity in a soybean oil system, better than BHT at the same concentration; inhibited lipoxygenase activity by >90% at a concentration of 62.5 mug/mL, with an IC(50) value of 21.6 mug/mL; and had IC(50) inhibitory values rate to (*)OH of 10.5 mg/L and a scavenging effect on O(2)(*)(-) of 17.6 mg/L.	Proanthocyanidins	29-41	linoleate 9S-lipoxygenase-4	Glycine max	155-167
15664304-6	2005	The extract, rutin and quercetin caused concentration-dependent inhibition of soybean Lox activity.	Rutin	13-18	linoleate 9S-lipoxygenase-4	Glycine max	86-89
15664304-6	2005	The extract, rutin and quercetin caused concentration-dependent inhibition of soybean Lox activity.	Quercetin	23-32	linoleate 9S-lipoxygenase-4	Glycine max	86-89
15664304-7	2005	These results indicate that rutin, quercetin and an extract of C. arabica containing these compounds inhibit Lox activity, consequently decreasing LTB4 production.	Rutin	28-33	linoleate 9S-lipoxygenase-4	Glycine max	109-112
15664304-7	2005	These results indicate that rutin, quercetin and an extract of C. arabica containing these compounds inhibit Lox activity, consequently decreasing LTB4 production.	Quercetin	35-44	linoleate 9S-lipoxygenase-4	Glycine max	109-112
14745171-0	2004	Tetrapetalone A, a novel lipoxygenase inhibitor from Streptomyces sp.	tetrapetalone A	0-15	linoleate 9S-lipoxygenase-4	Glycine max	25-37
15476400-1	2004	There is much debate whether the fatty acid substrate of lipoxygenase binds "carboxylate-end first" or "methyl-end first" in the active site of soybean lipoxygenase-1 (sLO-1).	Fatty Acids	33-43	linoleate 9S-lipoxygenase-4	Glycine max	57-69
15137872-0	2004	Lipoxygenase inhibitory activity of octyl gallate.	octyl gallate	36-49	linoleate 9S-lipoxygenase-4	Glycine max	0-12
15118321-2	2004	USF-4727 that produced a lipoxygenase inhibitor tetrapetalone A (1) simultaneously.	tetrapetalone A	48-63	linoleate 9S-lipoxygenase-4	Glycine max	25-37
15118321-5	2004	Tetrapetalone B, C, and D inhibited soybean lipoxygenase with IC(50): 320, 360, and 340 microM respectively.	tetrapetalone B	0-15	linoleate 9S-lipoxygenase-4	Glycine max	44-56
14993710-1	2004	4-Nitrocatechol (4NC) is a known inhibitor of lipoxygenase.	4-nitrocatechol	0-15	linoleate 9S-lipoxygenase-4	Glycine max	46-58
14993710-1	2004	4-Nitrocatechol (4NC) is a known inhibitor of lipoxygenase.	4-nitrocatechol	17-20	linoleate 9S-lipoxygenase-4	Glycine max	46-58
14993710-7	2004	A description of the catechol binding contributes to the understanding of lipoxygenase inhibition and the participation of its co-oxidative activity in the utilization of natural flavonoids.	catechol	21-29	linoleate 9S-lipoxygenase-4	Glycine max	74-86
14993710-7	2004	A description of the catechol binding contributes to the understanding of lipoxygenase inhibition and the participation of its co-oxidative activity in the utilization of natural flavonoids.	Flavonoids	179-189	linoleate 9S-lipoxygenase-4	Glycine max	74-86
15458348-0	2004	Chlorpromazine N-demethylation by hydroperoxidase activity of covalent immobilized lipoxygenase.	Chlorpromazine	0-14	linoleate 9S-lipoxygenase-4	Glycine max	83-95
15458348-2	2004	Previously (1) we have shown that immobilized lipoxygenase produces the oxidative degradation of CPZ in the presence of hydrogen peroxide.	Chlorpromazine	97-100	linoleate 9S-lipoxygenase-4	Glycine max	46-58
15458348-2	2004	Previously (1) we have shown that immobilized lipoxygenase produces the oxidative degradation of CPZ in the presence of hydrogen peroxide.	Hydrogen Peroxide	120-137	linoleate 9S-lipoxygenase-4	Glycine max	46-58
15458348-3	2004	As a continuation of this work, here we studied the N-demethylation of CPZ by the hydroperoxidase activity of covalent immobilized soybean lipoxygenase.	Nitrogen	52-53	linoleate 9S-lipoxygenase-4	Glycine max	139-151
15458348-3	2004	As a continuation of this work, here we studied the N-demethylation of CPZ by the hydroperoxidase activity of covalent immobilized soybean lipoxygenase.	Chlorpromazine	71-74	linoleate 9S-lipoxygenase-4	Glycine max	139-151
15458348-6	2004	The results obtained in this work, together with those obtained previously by us for the oxidation of CPZ, suggest that hydroperoxidase activity of immobilized lipoxygenase may constitute a valuable tool for oxidative xenobiotics degradation or for application to synthetic processes in which a N-demethylation reaction is involved.	Chlorpromazine	102-105	linoleate 9S-lipoxygenase-4	Glycine max	160-172
15458348-6	2004	The results obtained in this work, together with those obtained previously by us for the oxidation of CPZ, suggest that hydroperoxidase activity of immobilized lipoxygenase may constitute a valuable tool for oxidative xenobiotics degradation or for application to synthetic processes in which a N-demethylation reaction is involved.	Nitrogen	295-296	linoleate 9S-lipoxygenase-4	Glycine max	160-172
14745171-2	2004	This assay was used to find the novel lipoxygenase inhibitor, tetrapetalone A (1).	tetrapetalone A	62-77	linoleate 9S-lipoxygenase-4	Glycine max	38-50
14745171-9	2004	Tetrapetalone A showed similar inhibitory activity against soybean lipoxygenase to the two well-known lipoxygenase inhibitors, kojic acid and NDGA, while methylated tetrapetalone A (2) showed little inhibitory activity, even at a concentration of 1 mM.	tetrapetalone A	0-15	linoleate 9S-lipoxygenase-4	Glycine max	67-79
14745171-9	2004	Tetrapetalone A showed similar inhibitory activity against soybean lipoxygenase to the two well-known lipoxygenase inhibitors, kojic acid and NDGA, while methylated tetrapetalone A (2) showed little inhibitory activity, even at a concentration of 1 mM.	tetrapetalone A	0-15	linoleate 9S-lipoxygenase-4	Glycine max	102-114
14971310-1	2003	Lipoxygenase was extracted from African oil bean seed and purified by ammonium sulphate precipitation, gel filtration on Sephadex G-25 and ion-exchange chromatography on DEAE--cellulose column.	Ammonium Sulfate	70-87	linoleate 9S-lipoxygenase-4	Glycine max	0-12
14971310-1	2003	Lipoxygenase was extracted from African oil bean seed and purified by ammonium sulphate precipitation, gel filtration on Sephadex G-25 and ion-exchange chromatography on DEAE--cellulose column.	sephadex	121-134	linoleate 9S-lipoxygenase-4	Glycine max	0-12
14971310-1	2003	Lipoxygenase was extracted from African oil bean seed and purified by ammonium sulphate precipitation, gel filtration on Sephadex G-25 and ion-exchange chromatography on DEAE--cellulose column.	DEAE-Cellulose	170-185	linoleate 9S-lipoxygenase-4	Glycine max	0-12
12818687-0	2003	Novel thiazolyl, thiazolinyl and benzothiazolyl Schiff bases as possible lipoxygenase"s inhibitors and anti-inflammatory agents.	thiazolyl, thiazolinyl and benzothiazolyl schiff bases	6-60	linoleate 9S-lipoxygenase-4	Glycine max	73-85
15369335-0	2003	An unusual isotope effect on substrate inhibition in the oxidation of arachidonic acid by lipoxygenase.	Arachidonic Acid	70-86	linoleate 9S-lipoxygenase-4	Glycine max	90-102
15369335-1	2003	Soybean lipoxygenase catalyzes the oxidation of arachidonic acid to 15S-HPETE.	Arachidonic Acid	48-64	linoleate 9S-lipoxygenase-4	Glycine max	8-20
15369335-1	2003	Soybean lipoxygenase catalyzes the oxidation of arachidonic acid to 15S-HPETE.	15-hydroperoxy-5,8,11,13-eicosatetraenoic acid	68-77	linoleate 9S-lipoxygenase-4	Glycine max	8-20
12826254-0	2003	Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of omega-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and tandem MS. With the combined techniques of on-line liquid chromatography/electron spin resonance (LC/ESR) and on-line liquid chromatography/mass spectrometry (LC/MS), we have previously characterized all classes of lipid-derived carbon-centered radicals (*Ld) formed from omega-6 polyunsaturated fatty acids (PUFAs: linoleic acid and arachidonic acid).	Carbon	31-37	linoleate 9S-lipoxygenase-4	Glycine max	67-79
12826254-0	2003	Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of omega-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and tandem MS. With the combined techniques of on-line liquid chromatography/electron spin resonance (LC/ESR) and on-line liquid chromatography/mass spectrometry (LC/MS), we have previously characterized all classes of lipid-derived carbon-centered radicals (*Ld) formed from omega-6 polyunsaturated fatty acids (PUFAs: linoleic acid and arachidonic acid).	omega-3 polyunsaturated fatty acids	107-142	linoleate 9S-lipoxygenase-4	Glycine max	67-79
12964012-0	2003	Inhibition of lipoxygenase by (-)-epigallocatechin gallate: X-ray analysis at 2.1 A reveals degradation of EGCG and shows soybean LOX-3 complex with EGC instead.	epigallocatechin gallate	30-58	linoleate 9S-lipoxygenase-4	Glycine max	14-26
12964012-0	2003	Inhibition of lipoxygenase by (-)-epigallocatechin gallate: X-ray analysis at 2.1 A reveals degradation of EGCG and shows soybean LOX-3 complex with EGC instead.	epigallocatechin gallate	107-111	linoleate 9S-lipoxygenase-4	Glycine max	14-26
12964012-0	2003	Inhibition of lipoxygenase by (-)-epigallocatechin gallate: X-ray analysis at 2.1 A reveals degradation of EGCG and shows soybean LOX-3 complex with EGC instead.	gallocatechol	107-110	linoleate 9S-lipoxygenase-4	Glycine max	14-26
12964012-5	2003	This work presents results obtained from an X-ray analysis of (-)-epigallocatechin gallate (EGCG) interacting with soybean lipoxygenase-3.	epigallocatechin gallate	62-90	linoleate 9S-lipoxygenase-4	Glycine max	123-135
12964012-5	2003	This work presents results obtained from an X-ray analysis of (-)-epigallocatechin gallate (EGCG) interacting with soybean lipoxygenase-3.	epigallocatechin gallate	92-96	linoleate 9S-lipoxygenase-4	Glycine max	123-135
12105892-3	2002	Modeling of the isotope effect data allows for a comparison to the hydrogen transfer catalyzed by soybean lipoxygenase in terms of environmental reorganization energy and frequency of the protein vibration that controls the hydrogen transfer.	Hydrogen	67-75	linoleate 9S-lipoxygenase-4	Glycine max	106-118
12792803-0	2003	Structure of curcumin in complex with lipoxygenase and its significance in cancer.	Curcumin	13-21	linoleate 9S-lipoxygenase-4	Glycine max	38-50
12792803-3	2003	This work delivers the first 3D structural data and explains how curcumin interacts with the fatty acid metabolizing enzyme, soybean lipoxygenase.	Curcumin	65-73	linoleate 9S-lipoxygenase-4	Glycine max	133-145
12792803-3	2003	This work delivers the first 3D structural data and explains how curcumin interacts with the fatty acid metabolizing enzyme, soybean lipoxygenase.	Fatty Acids	93-103	linoleate 9S-lipoxygenase-4	Glycine max	133-145
12792803-4	2003	Curcumin binds to lipoxygenase in a non-competitive manner.	Curcumin	0-8	linoleate 9S-lipoxygenase-4	Glycine max	18-30
12495021-4	2002	Autoclaved whole seeds, with or without LOX, produced good fungal growth and aflatoxin levels approaching those of broken seeds.	Aflatoxins	77-86	linoleate 9S-lipoxygenase-4	Glycine max	40-43
12234194-0	2002	Irreversible inactivation of soybean lipoxygenase-1 by hydrophobic thiols.	Sulfhydryl Compounds	67-73	linoleate 9S-lipoxygenase-4	Glycine max	37-49
12234194-1	2002	Soybean lipoxygenase-1 is inactivated by micromolar concentrations of the following hydrophobic thiols: 1-octanethiol, 12(S)-mercapto-9(Z)-octadecenoic acid (S-12-HSODE), 12(R)-mercapto-9(Z)-octadecenoic acid (R-12-HSODE), and 12-mercaptooctadecanoic acid (12-HSODA).	Sulfhydryl Compounds	96-102	linoleate 9S-lipoxygenase-4	Glycine max	8-20
12234194-1	2002	Soybean lipoxygenase-1 is inactivated by micromolar concentrations of the following hydrophobic thiols: 1-octanethiol, 12(S)-mercapto-9(Z)-octadecenoic acid (S-12-HSODE), 12(R)-mercapto-9(Z)-octadecenoic acid (R-12-HSODE), and 12-mercaptooctadecanoic acid (12-HSODA).	n-octanethiol	104-117	linoleate 9S-lipoxygenase-4	Glycine max	8-20
12234194-1	2002	Soybean lipoxygenase-1 is inactivated by micromolar concentrations of the following hydrophobic thiols: 1-octanethiol, 12(S)-mercapto-9(Z)-octadecenoic acid (S-12-HSODE), 12(R)-mercapto-9(Z)-octadecenoic acid (R-12-HSODE), and 12-mercaptooctadecanoic acid (12-HSODA).	12(s)-mercapto-9(z)-octadecenoic acid	119-156	linoleate 9S-lipoxygenase-4	Glycine max	8-20
12234194-1	2002	Soybean lipoxygenase-1 is inactivated by micromolar concentrations of the following hydrophobic thiols: 1-octanethiol, 12(S)-mercapto-9(Z)-octadecenoic acid (S-12-HSODE), 12(R)-mercapto-9(Z)-octadecenoic acid (R-12-HSODE), and 12-mercaptooctadecanoic acid (12-HSODA).	s-12-hsode	158-168	linoleate 9S-lipoxygenase-4	Glycine max	8-20
12234194-1	2002	Soybean lipoxygenase-1 is inactivated by micromolar concentrations of the following hydrophobic thiols: 1-octanethiol, 12(S)-mercapto-9(Z)-octadecenoic acid (S-12-HSODE), 12(R)-mercapto-9(Z)-octadecenoic acid (R-12-HSODE), and 12-mercaptooctadecanoic acid (12-HSODA).	12(r)-mercapto-9(z)-octadecenoic acid	171-208	linoleate 9S-lipoxygenase-4	Glycine max	8-20
12234194-1	2002	Soybean lipoxygenase-1 is inactivated by micromolar concentrations of the following hydrophobic thiols: 1-octanethiol, 12(S)-mercapto-9(Z)-octadecenoic acid (S-12-HSODE), 12(R)-mercapto-9(Z)-octadecenoic acid (R-12-HSODE), and 12-mercaptooctadecanoic acid (12-HSODA).	r-12-hsode	210-220	linoleate 9S-lipoxygenase-4	Glycine max	8-20
12234194-1	2002	Soybean lipoxygenase-1 is inactivated by micromolar concentrations of the following hydrophobic thiols: 1-octanethiol, 12(S)-mercapto-9(Z)-octadecenoic acid (S-12-HSODE), 12(R)-mercapto-9(Z)-octadecenoic acid (R-12-HSODE), and 12-mercaptooctadecanoic acid (12-HSODA).	12-mercaptooctadecanoic acid	227-255	linoleate 9S-lipoxygenase-4	Glycine max	8-20
12234194-1	2002	Soybean lipoxygenase-1 is inactivated by micromolar concentrations of the following hydrophobic thiols: 1-octanethiol, 12(S)-mercapto-9(Z)-octadecenoic acid (S-12-HSODE), 12(R)-mercapto-9(Z)-octadecenoic acid (R-12-HSODE), and 12-mercaptooctadecanoic acid (12-HSODA).	12-hsoda	257-265	linoleate 9S-lipoxygenase-4	Glycine max	8-20
12234194-4	2002	Lipoxygenase catalyzes an oxygenation reaction on each of the aforementioned thiols, as judged by the consumption of O(2).	Sulfhydryl Compounds	77-83	linoleate 9S-lipoxygenase-4	Glycine max	0-12
12234194-4	2002	Lipoxygenase catalyzes an oxygenation reaction on each of the aforementioned thiols, as judged by the consumption of O(2).	Oxygen	117-121	linoleate 9S-lipoxygenase-4	Glycine max	0-12
12234194-11	2002	The results imply that hydrophobic thiols irreversibly inactivate soybean lipoxygenase by a mechanism that involves oxidation at sulfur.	Sulfhydryl Compounds	35-41	linoleate 9S-lipoxygenase-4	Glycine max	74-86
12234194-11	2002	The results imply that hydrophobic thiols irreversibly inactivate soybean lipoxygenase by a mechanism that involves oxidation at sulfur.	Sulfur	129-135	linoleate 9S-lipoxygenase-4	Glycine max	74-86
12105957-0	2002	Development of a biocatalytic process for the production of c6-aldehydes from vegetable oils by soybean lipoxygenase and recombinant hydroperoxide lyase.	n-hexanal	60-72	linoleate 9S-lipoxygenase-4	Glycine max	104-116
12105957-0	2002	Development of a biocatalytic process for the production of c6-aldehydes from vegetable oils by soybean lipoxygenase and recombinant hydroperoxide lyase.	Plant Oils	78-92	linoleate 9S-lipoxygenase-4	Glycine max	104-116
12105957-3	2002	Vegetable oils were converted by soybean lipoxygenase and recombinant hydroperoxide lyase into hexanal and (2E)- or (3Z)-hexenal.	Plant Oils	0-14	linoleate 9S-lipoxygenase-4	Glycine max	41-53
12826254-0	2003	Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of omega-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and tandem MS. With the combined techniques of on-line liquid chromatography/electron spin resonance (LC/ESR) and on-line liquid chromatography/mass spectrometry (LC/MS), we have previously characterized all classes of lipid-derived carbon-centered radicals (*Ld) formed from omega-6 polyunsaturated fatty acids (PUFAs: linoleic acid and arachidonic acid).	carbon-centered radicals	31-55	linoleate 9S-lipoxygenase-4	Glycine max	67-79
12826254-0	2003	Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of omega-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and tandem MS. With the combined techniques of on-line liquid chromatography/electron spin resonance (LC/ESR) and on-line liquid chromatography/mass spectrometry (LC/MS), we have previously characterized all classes of lipid-derived carbon-centered radicals (*Ld) formed from omega-6 polyunsaturated fatty acids (PUFAs: linoleic acid and arachidonic acid).	omega-6 polyunsaturated fatty acids	437-472	linoleate 9S-lipoxygenase-4	Glycine max	67-79
12826254-0	2003	Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of omega-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and tandem MS. With the combined techniques of on-line liquid chromatography/electron spin resonance (LC/ESR) and on-line liquid chromatography/mass spectrometry (LC/MS), we have previously characterized all classes of lipid-derived carbon-centered radicals (*Ld) formed from omega-6 polyunsaturated fatty acids (PUFAs: linoleic acid and arachidonic acid).	Fatty Acids, Unsaturated	474-479	linoleate 9S-lipoxygenase-4	Glycine max	67-79
12826254-0	2003	Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of omega-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and tandem MS. With the combined techniques of on-line liquid chromatography/electron spin resonance (LC/ESR) and on-line liquid chromatography/mass spectrometry (LC/MS), we have previously characterized all classes of lipid-derived carbon-centered radicals (*Ld) formed from omega-6 polyunsaturated fatty acids (PUFAs: linoleic acid and arachidonic acid).	Linoleic Acid	481-494	linoleate 9S-lipoxygenase-4	Glycine max	67-79
12826254-0	2003	Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of omega-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and tandem MS. With the combined techniques of on-line liquid chromatography/electron spin resonance (LC/ESR) and on-line liquid chromatography/mass spectrometry (LC/MS), we have previously characterized all classes of lipid-derived carbon-centered radicals (*Ld) formed from omega-6 polyunsaturated fatty acids (PUFAs: linoleic acid and arachidonic acid).	Arachidonic Acid	499-515	linoleate 9S-lipoxygenase-4	Glycine max	67-79
12826254-1	2003	In the present study, the carbon-centered radicals formed from two omega-3 PUFAs (linolenic acid and docosahexaenoic acid) resulting from their reactions with soybean lipoxygenase in the presence of alpha-[4-pyridyl 1-oxide]-N-tert-butylnitrone (POBN) were investigated using the combination of LC/ESR and LC/MS techniques.	Carbon	26-32	linoleate 9S-lipoxygenase-4	Glycine max	167-179
12826254-1	2003	In the present study, the carbon-centered radicals formed from two omega-3 PUFAs (linolenic acid and docosahexaenoic acid) resulting from their reactions with soybean lipoxygenase in the presence of alpha-[4-pyridyl 1-oxide]-N-tert-butylnitrone (POBN) were investigated using the combination of LC/ESR and LC/MS techniques.	alpha-Linolenic Acid	82-96	linoleate 9S-lipoxygenase-4	Glycine max	167-179
12826254-1	2003	In the present study, the carbon-centered radicals formed from two omega-3 PUFAs (linolenic acid and docosahexaenoic acid) resulting from their reactions with soybean lipoxygenase in the presence of alpha-[4-pyridyl 1-oxide]-N-tert-butylnitrone (POBN) were investigated using the combination of LC/ESR and LC/MS techniques.	Docosahexaenoic Acids	101-121	linoleate 9S-lipoxygenase-4	Glycine max	167-179
12826254-1	2003	In the present study, the carbon-centered radicals formed from two omega-3 PUFAs (linolenic acid and docosahexaenoic acid) resulting from their reactions with soybean lipoxygenase in the presence of alpha-[4-pyridyl 1-oxide]-N-tert-butylnitrone (POBN) were investigated using the combination of LC/ESR and LC/MS techniques.	alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone	199-244	linoleate 9S-lipoxygenase-4	Glycine max	167-179
12826254-1	2003	In the present study, the carbon-centered radicals formed from two omega-3 PUFAs (linolenic acid and docosahexaenoic acid) resulting from their reactions with soybean lipoxygenase in the presence of alpha-[4-pyridyl 1-oxide]-N-tert-butylnitrone (POBN) were investigated using the combination of LC/ESR and LC/MS techniques.	POBN	246-250	linoleate 9S-lipoxygenase-4	Glycine max	167-179
12617600-0	2003	Oxidation of resveratrol catalyzed by soybean lipoxygenase.	Resveratrol	13-24	linoleate 9S-lipoxygenase-4	Glycine max	46-58
12617600-4	2003	When resveratrol was incubated in the presence of lipoxygenase at pH 9.0, the reaction displayed a k(M) value of 18.6 x 10(-)(6) M and a catalytic efficiency (k(cat)/k(M)) of 4.3 x 10(4) s(-)(1) M(-)(1).	Resveratrol	5-16	linoleate 9S-lipoxygenase-4	Glycine max	50-62
12617600-6	2003	The effect of lipoxygenase inhibitors on the lipoxygenase-catalyzed resveratrol oxidation was also evaluated.	Resveratrol	68-79	linoleate 9S-lipoxygenase-4	Glycine max	14-26
12617600-6	2003	The effect of lipoxygenase inhibitors on the lipoxygenase-catalyzed resveratrol oxidation was also evaluated.	Resveratrol	68-79	linoleate 9S-lipoxygenase-4	Glycine max	45-57
12105957-3	2002	Vegetable oils were converted by soybean lipoxygenase and recombinant hydroperoxide lyase into hexanal and (2E)- or (3Z)-hexenal.	(2e)- or (3z)-hexenal	107-128	linoleate 9S-lipoxygenase-4	Glycine max	41-53
12105892-3	2002	Modeling of the isotope effect data allows for a comparison to the hydrogen transfer catalyzed by soybean lipoxygenase in terms of environmental reorganization energy and frequency of the protein vibration that controls the hydrogen transfer.	Hydrogen	224-232	linoleate 9S-lipoxygenase-4	Glycine max	106-118
12130848-0	2002	Synthesis of new azulene derivatives and study of their effect on lipid peroxidation and lipoxygenase activity.	azulene	17-24	linoleate 9S-lipoxygenase-4	Glycine max	89-101
11983531-0	2002	A simple method for the preparation of (5Z,8Z,11Z,14Z)-16-hydroxyeicosa-5,8,11,14-tetraenoic acid enantiomers and the corresponding 14,15-dehydro analogues: role of the 16-hydroxy group for the lipoxygenase reaction.	16-hydroxy-5,8,11,14-eicosatetraenoic acid	39-97	linoleate 9S-lipoxygenase-4	Glycine max	194-206
11983531-4	2002	When 16-HETE was tested as lipoxygenase substrate, we found that it is well oxygenated by the soybean 15-lipoxygenase and by the recombinant human 5-lipoxygenase.	16-hydroxy-5,8,11,14-eicosatetraenoic acid	5-12	linoleate 9S-lipoxygenase-4	Glycine max	27-39
11983531-4	2002	When 16-HETE was tested as lipoxygenase substrate, we found that it is well oxygenated by the soybean 15-lipoxygenase and by the recombinant human 5-lipoxygenase.	16-hydroxy-5,8,11,14-eicosatetraenoic acid	5-12	linoleate 9S-lipoxygenase-4	Glycine max	105-117
11983531-6	2002	In contrast, the product pattern of 16-HETE methyl ester oxygenation by the soybean lipoxygenase (5-lipoxygenation) may be explained by an inverse head to tail substrate orientation.	16-hete methyl ester	36-56	linoleate 9S-lipoxygenase-4	Glycine max	84-96
11807975-0	2002	Abietic acid inhibits lipoxygenase activity.	abietic acid	0-12	linoleate 9S-lipoxygenase-4	Glycine max	22-34
12033451-2	2002	It has been known that lipoxygenase-mediated lipid peroxidation proceeds in general via regio-, stereo- and enantio-specific mechanisms, but that it is sometimes accompanied by a share of random hydroperoxides as side reaction products.	Hydrogen Peroxide	195-209	linoleate 9S-lipoxygenase-4	Glycine max	23-35
12033451-3	2002	In this study we investigated the oxidation of various substrates (linoleic acid, methyl linoleate, phosphatidylcholine, isolated LDL, and human plasma) by the arachidonate 15-lipoxygenases from rabbit reticulocytes and soybeans aiming at elucidating the effects of substrate, lipoxygenase and reaction milieu on the contribution and mechanism of random oxidation and also the effect of antioxidant.	Linoleic Acid	67-80	linoleate 9S-lipoxygenase-4	Glycine max	176-188
12033451-3	2002	In this study we investigated the oxidation of various substrates (linoleic acid, methyl linoleate, phosphatidylcholine, isolated LDL, and human plasma) by the arachidonate 15-lipoxygenases from rabbit reticulocytes and soybeans aiming at elucidating the effects of substrate, lipoxygenase and reaction milieu on the contribution and mechanism of random oxidation and also the effect of antioxidant.	methyl linoleate	82-98	linoleate 9S-lipoxygenase-4	Glycine max	176-188
12033451-3	2002	In this study we investigated the oxidation of various substrates (linoleic acid, methyl linoleate, phosphatidylcholine, isolated LDL, and human plasma) by the arachidonate 15-lipoxygenases from rabbit reticulocytes and soybeans aiming at elucidating the effects of substrate, lipoxygenase and reaction milieu on the contribution and mechanism of random oxidation and also the effect of antioxidant.	Phosphatidylcholines	100-119	linoleate 9S-lipoxygenase-4	Glycine max	176-188
12033451-6	2002	When phosphatidylcholine liposomes and LDL were oxygenated by soybean lipoxygenase, the product pattern was found to be exclusively regio-, stereo-, and enantio-random.	Phosphatidylcholines	5-24	linoleate 9S-lipoxygenase-4	Glycine max	70-82
12033451-7	2002	When free linoleic acid was incorporated into PC liposomes and oxidized by soybean lipoxygenase, the free acid was specifically oxygenated, whereas esterified linoleate gave random oxidation products exclusively.	Linoleic Acid	10-23	linoleate 9S-lipoxygenase-4	Glycine max	83-95
12033451-7	2002	When free linoleic acid was incorporated into PC liposomes and oxidized by soybean lipoxygenase, the free acid was specifically oxygenated, whereas esterified linoleate gave random oxidation products exclusively.	streptolydigin	101-110	linoleate 9S-lipoxygenase-4	Glycine max	83-95
11807975-1	2002	In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase (linoleate: oxygen oxidoreductase, EC 1.13.11.12) and an IC(50) of 29.5 +/- 1.29 microM was determined.	abietic acid	33-45	linoleate 9S-lipoxygenase-4	Glycine max	92-104
11807975-1	2002	In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase (linoleate: oxygen oxidoreductase, EC 1.13.11.12) and an IC(50) of 29.5 +/- 1.29 microM was determined.	Abietanes	50-58	linoleate 9S-lipoxygenase-4	Glycine max	92-104
11807975-1	2002	In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase (linoleate: oxygen oxidoreductase, EC 1.13.11.12) and an IC(50) of 29.5 +/- 1.29 microM was determined.	Diterpenes	59-70	linoleate 9S-lipoxygenase-4	Glycine max	92-104
11807975-2	2002	Since the lipoxygenase pathway leads to the biosynthesis of leukotrienes this result supports the view that abietic acid may be used in the treatment of allergic reactions.	Leukotrienes	60-72	linoleate 9S-lipoxygenase-4	Glycine max	10-22
11807975-2	2002	Since the lipoxygenase pathway leads to the biosynthesis of leukotrienes this result supports the view that abietic acid may be used in the treatment of allergic reactions.	abietic acid	108-120	linoleate 9S-lipoxygenase-4	Glycine max	10-22
11566371-3	2001	Because of the structural similarities between both compounds it was assumed for the amidrazones to affect the lipoxygenase reaction in the same suicide manner.	amidrazones	85-96	linoleate 9S-lipoxygenase-4	Glycine max	111-123
11602611-0	2001	Structure-function investigation of the interaction of 1- and 2-substituted 3-hydroxypyridin-4-ones with 5-lipoxygenase and ribonucleotide reductase.	1- and 2-substituted 3-hydroxypyridin-4-ones	55-99	linoleate 9S-lipoxygenase-4	Glycine max	107-119
11602611-1	2001	The structural and physiochemical properties of 3-hydroxypyridin-4-one chelators (HPOs) which influence inhibition of the iron-containing metalloenzymes ribonucleotide reductase (RR) and 5-lipoxygenase (5-LO) have been investigated.	3-hydroxypyridin-4-one	48-70	linoleate 9S-lipoxygenase-4	Glycine max	189-201
11602611-1	2001	The structural and physiochemical properties of 3-hydroxypyridin-4-one chelators (HPOs) which influence inhibition of the iron-containing metalloenzymes ribonucleotide reductase (RR) and 5-lipoxygenase (5-LO) have been investigated.	Iron	122-126	linoleate 9S-lipoxygenase-4	Glycine max	189-201
11602611-5	2001	5-LO inhibition was examined spectrophotometrically, measuring the rate of linoleic hydroperoxide formation by soybean lipoxygenase.	linoleic hydroperoxide	75-97	linoleate 9S-lipoxygenase-4	Glycine max	119-131
11767313-2	2001	Phosphatidylcholine hydroperoxides and cholesteryl linoleate hydroperoxides ranging from 0.1 to 0.5 nmol, which were prepared by reaction with soybean lipoxygenase, were visualized as fluorescent spots on the blotted membrane by immersing the plate into a blotting solvent containing 0.01% (w/v) diphenyl-1-pyrenylphosphine.	phosphatidylcholine hydroperoxide	0-34	linoleate 9S-lipoxygenase-4	Glycine max	151-163
11767313-2	2001	Phosphatidylcholine hydroperoxides and cholesteryl linoleate hydroperoxides ranging from 0.1 to 0.5 nmol, which were prepared by reaction with soybean lipoxygenase, were visualized as fluorescent spots on the blotted membrane by immersing the plate into a blotting solvent containing 0.01% (w/v) diphenyl-1-pyrenylphosphine.	cholesteryl linoleate hydroperoxides	39-75	linoleate 9S-lipoxygenase-4	Glycine max	151-163
11767313-2	2001	Phosphatidylcholine hydroperoxides and cholesteryl linoleate hydroperoxides ranging from 0.1 to 0.5 nmol, which were prepared by reaction with soybean lipoxygenase, were visualized as fluorescent spots on the blotted membrane by immersing the plate into a blotting solvent containing 0.01% (w/v) diphenyl-1-pyrenylphosphine.	diphenyl-1-pyrenylphosphine	296-323	linoleate 9S-lipoxygenase-4	Glycine max	151-163
11412104-3	2001	This study utilizes a combination of kinetic and structural probes to relate the lipoxygenase mechanism of action with structural modifications of the iron"s second coordination sphere.	Iron	151-155	linoleate 9S-lipoxygenase-4	Glycine max	81-93
11592738-1	2001	Lipoxygenase (LOX) is an enzyme that oxygenates polyunsaturated fatty acids to their corresponding hydroperoxy derivatives.	Fatty Acids, Unsaturated	48-75	linoleate 9S-lipoxygenase-4	Glycine max	0-12
11592738-1	2001	Lipoxygenase (LOX) is an enzyme that oxygenates polyunsaturated fatty acids to their corresponding hydroperoxy derivatives.	Fatty Acids, Unsaturated	48-75	linoleate 9S-lipoxygenase-4	Glycine max	14-17
11592738-2	2001	For example, LOX found in plants produce the corresponding 13- and 9-hydroperoxide derivatives of linoleic acid (13-HPOD and 9-HPOD).	13- and 9-hydroperoxide	59-82	linoleate 9S-lipoxygenase-4	Glycine max	13-16
11592738-2	2001	For example, LOX found in plants produce the corresponding 13- and 9-hydroperoxide derivatives of linoleic acid (13-HPOD and 9-HPOD).	Linoleic Acid	98-111	linoleate 9S-lipoxygenase-4	Glycine max	13-16
11592738-2	2001	For example, LOX found in plants produce the corresponding 13- and 9-hydroperoxide derivatives of linoleic acid (13-HPOD and 9-HPOD).	13-hydroperoxy-9,11-octadecadienoic acid	113-120	linoleate 9S-lipoxygenase-4	Glycine max	13-16
11592738-2	2001	For example, LOX found in plants produce the corresponding 13- and 9-hydroperoxide derivatives of linoleic acid (13-HPOD and 9-HPOD).	9-hydroperoxy-10,12-octadecadienoic acid	125-131	linoleate 9S-lipoxygenase-4	Glycine max	13-16
11592738-4	2001	Here we report a high-performance liquid chromatographic method in combination with electron impact (EI)-MS detection that separates and characterizes the HPOD isomers generated by soybean LOX type I oxygenation of linoleic (LA) and linolenic acids as well as HPOD products produced by photosensitized oxidation of LA.	Linoleic Acid	215-223	linoleate 9S-lipoxygenase-4	Glycine max	189-192
11592738-4	2001	Here we report a high-performance liquid chromatographic method in combination with electron impact (EI)-MS detection that separates and characterizes the HPOD isomers generated by soybean LOX type I oxygenation of linoleic (LA) and linolenic acids as well as HPOD products produced by photosensitized oxidation of LA.	Linolenic Acids	233-248	linoleate 9S-lipoxygenase-4	Glycine max	189-192
11592738-8	2001	Moreover, the 9-LOX isozyme under anaerobic conditions cleaves 13-HPOD to 13-oxo-tridecadienoic acid and pentane but does not cleave 9-HPOD.	13-hydroperoxy-9,11-octadecadienoic acid	63-70	linoleate 9S-lipoxygenase-4	Glycine max	16-19
11592738-8	2001	Moreover, the 9-LOX isozyme under anaerobic conditions cleaves 13-HPOD to 13-oxo-tridecadienoic acid and pentane but does not cleave 9-HPOD.	13-oxotrideca-9,11-dienoic acid	74-100	linoleate 9S-lipoxygenase-4	Glycine max	16-19
11592738-8	2001	Moreover, the 9-LOX isozyme under anaerobic conditions cleaves 13-HPOD to 13-oxo-tridecadienoic acid and pentane but does not cleave 9-HPOD.	pentane	105-112	linoleate 9S-lipoxygenase-4	Glycine max	16-19
11456594-0	2001	Soybean lipoxygenase-mediated oxygenation of monounsaturated fatty acids to enones.	Fatty Acids, Monounsaturated	45-72	linoleate 9S-lipoxygenase-4	Glycine max	8-20
11550050-1	2001	Free radical oxidation of arachidonic acid with soybean lipoxygenase was accompanied by inhibition of retinal synthesis from beta-carotene catalyzed by enzyme preparation from rabbit intestinal mucosa.	Arachidonic Acid	26-42	linoleate 9S-lipoxygenase-4	Glycine max	56-68
11550050-1	2001	Free radical oxidation of arachidonic acid with soybean lipoxygenase was accompanied by inhibition of retinal synthesis from beta-carotene catalyzed by enzyme preparation from rabbit intestinal mucosa.	beta Carotene	125-138	linoleate 9S-lipoxygenase-4	Glycine max	56-68
11361131-0	2001	Activity of soybean lipoxygenase isoforms against esterified fatty acids indicates functional specificity.	Fatty Acids	50-72	linoleate 9S-lipoxygenase-4	Glycine max	20-32
11361131-4	2001	The recombinant lipoxygenases were then characterized as to substrate preference, pH profiles for the most common plant lipoxygenase substrates, linoleic acid, and alpha-linolenic acid, and the reaction products with the substrates linoleic acid, alpha-linolenic acid, arachidonic acid, gamma-linolenic acid, and the triacylglycerol trilinolein.	Linoleic Acid	145-158	linoleate 9S-lipoxygenase-4	Glycine max	16-28
11361131-4	2001	The recombinant lipoxygenases were then characterized as to substrate preference, pH profiles for the most common plant lipoxygenase substrates, linoleic acid, and alpha-linolenic acid, and the reaction products with the substrates linoleic acid, alpha-linolenic acid, arachidonic acid, gamma-linolenic acid, and the triacylglycerol trilinolein.	alpha-Linolenic Acid	164-184	linoleate 9S-lipoxygenase-4	Glycine max	16-28
11361131-4	2001	The recombinant lipoxygenases were then characterized as to substrate preference, pH profiles for the most common plant lipoxygenase substrates, linoleic acid, and alpha-linolenic acid, and the reaction products with the substrates linoleic acid, alpha-linolenic acid, arachidonic acid, gamma-linolenic acid, and the triacylglycerol trilinolein.	Linoleic Acid	232-245	linoleate 9S-lipoxygenase-4	Glycine max	16-28
11361131-7	2001	Lipid analysis of leaves from plants subjected to sink limitation conditions indicates that the soybean leaf lipoxygenases are active in vivo against both free fatty acids and esterified lipids, and that the quantities of lipoxygenase products found in leaf tissue show a positive correlation with the level of lipoxygenase in the leaf.	Fatty Acids, Nonesterified	155-171	linoleate 9S-lipoxygenase-4	Glycine max	109-121
11456594-0	2001	Soybean lipoxygenase-mediated oxygenation of monounsaturated fatty acids to enones.	enones	76-82	linoleate 9S-lipoxygenase-4	Glycine max	8-20
11029517-0	2000	Curcumin inhibits lipoxygenase by binding to its central cavity: theoretical and X-ray evidence.	Curcumin	0-8	linoleate 9S-lipoxygenase-4	Glycine max	18-30
11163536-5	2001	The slow-flow technique allowed us to obtain well-resolved ESR spectra of PUFA-derived radical adducts in a mixture of soybean lipoxygenase, PUFA, and the spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO).	Fatty Acids, Unsaturated	74-78	linoleate 9S-lipoxygenase-4	Glycine max	127-139
11163536-5	2001	The slow-flow technique allowed us to obtain well-resolved ESR spectra of PUFA-derived radical adducts in a mixture of soybean lipoxygenase, PUFA, and the spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO).	5,5-dimethyl-1-pyrroline-1-oxide	199-203	linoleate 9S-lipoxygenase-4	Glycine max	127-139
30759919-7	2001	The partial amino acid sequences from the purified NAA-induced pI-5.09 LOX are identical to those of LOX4.	1-naphthaleneacetic acid	51-54	linoleate 9S-lipoxygenase-4	Glycine max	101-105
30759919-8	2001	RNA protection assays showed that NAA induces the expression of LOX4 and LOX5 mRNAs in cultured embryo cotyledons where they are not normally expressed.	1-naphthaleneacetic acid	34-37	linoleate 9S-lipoxygenase-4	Glycine max	64-68
30759919-9	2001	Soybean genotypes with a polymorphic variant of LOX4 in hypocotyls showed the same variation as NAA-induced LOXs in the embryo cotyledons.	1-naphthaleneacetic acid	96-99	linoleate 9S-lipoxygenase-4	Glycine max	48-52
30759919-10	2001	These results demonstrate that the NAA-induced pI-5.09 LOX is seedling LOX4 and also suggest that auxin might be directly or indirectly involved in seedling LOX expression during seed germination.	1-naphthaleneacetic acid	35-38	linoleate 9S-lipoxygenase-4	Glycine max	71-75
11029517-1	2000	Many lipoxygenase inhibitors including curcumin are currently being studied for their anti-carcinogenic properties.	Curcumin	39-47	linoleate 9S-lipoxygenase-4	Glycine max	5-17
11029517-3	2000	Recently it was shown that the soybean lipoxygenase L1 catalyzed the oxygenation of curcumin and that curcumin can act as a lipoxygenase substrate.	Curcumin	84-92	linoleate 9S-lipoxygenase-4	Glycine max	39-51
11029517-3	2000	Recently it was shown that the soybean lipoxygenase L1 catalyzed the oxygenation of curcumin and that curcumin can act as a lipoxygenase substrate.	Curcumin	102-110	linoleate 9S-lipoxygenase-4	Glycine max	39-51
11029517-6	2000	Understanding how curcumin inhibits lipoxygenase may help in the development of novel anti-cancer drugs used for treatment where lipoxygenases are involved.	Curcumin	18-26	linoleate 9S-lipoxygenase-4	Glycine max	36-48
10769137-2	2000	Steady-state kinetic data indicate that oleic acid (OA) is a simple competitive inhibitor for soybean lipoxygenase; however, kinetic isotope effect (KIE) data suggest a more complicated inhibitory mechanism.	Oleic Acid	40-50	linoleate 9S-lipoxygenase-4	Glycine max	102-114
11007531-1	2000	Oxidized metabolites of polyunsaturated fatty acids produced by lipoxygenase are among the endogenous regulators of Na+/K+-ATPase.	Fatty Acids, Unsaturated	24-51	linoleate 9S-lipoxygenase-4	Glycine max	64-76
11007531-6	2000	The presence of lipoxygenase enhanced the inhibition of Na+/K+-ATPase activity caused by 20 ng/mL ouabain (31+/-2 vs. 19+/-2) but had little or no effect with higher concentrations of ouabain.	Ouabain	98-105	linoleate 9S-lipoxygenase-4	Glycine max	16-28
11007531-6	2000	The presence of lipoxygenase enhanced the inhibition of Na+/K+-ATPase activity caused by 20 ng/mL ouabain (31+/-2 vs. 19+/-2) but had little or no effect with higher concentrations of ouabain.	Ouabain	184-191	linoleate 9S-lipoxygenase-4	Glycine max	16-28
10785362-5	2000	The results obtained showed that soybean lipoxygenase in the presence of hydrogen peroxide can oxidize homovanillic acid with the formation, by an o,o"-biphenyl linkage, of the corresponding dimer as the sole reaction product.	Hydrogen Peroxide	73-90	linoleate 9S-lipoxygenase-4	Glycine max	41-53
10785362-5	2000	The results obtained showed that soybean lipoxygenase in the presence of hydrogen peroxide can oxidize homovanillic acid with the formation, by an o,o"-biphenyl linkage, of the corresponding dimer as the sole reaction product.	Homovanillic Acid	103-120	linoleate 9S-lipoxygenase-4	Glycine max	41-53
10769137-3	2000	To investigate the inhibitory effects of fatty acids on lipoxygenase more thoroughly, we have synthesized a novel inhibitor to lipoxygenase, (Z)-9-octadecenyl sulfate (oleyl sulfate, OS), which imparts kinetic properties that are inconsistent with simple competitive inhibition for both SLO-1 and 15-HLO.	Fatty Acids	41-52	linoleate 9S-lipoxygenase-4	Glycine max	127-139
10769137-3	2000	To investigate the inhibitory effects of fatty acids on lipoxygenase more thoroughly, we have synthesized a novel inhibitor to lipoxygenase, (Z)-9-octadecenyl sulfate (oleyl sulfate, OS), which imparts kinetic properties that are inconsistent with simple competitive inhibition for both SLO-1 and 15-HLO.	(z)-9-octadecenyl sulfate	141-166	linoleate 9S-lipoxygenase-4	Glycine max	56-68
10769137-3	2000	To investigate the inhibitory effects of fatty acids on lipoxygenase more thoroughly, we have synthesized a novel inhibitor to lipoxygenase, (Z)-9-octadecenyl sulfate (oleyl sulfate, OS), which imparts kinetic properties that are inconsistent with simple competitive inhibition for both SLO-1 and 15-HLO.	(z)-9-octadecenyl sulfate	141-166	linoleate 9S-lipoxygenase-4	Glycine max	127-139
10769137-3	2000	To investigate the inhibitory effects of fatty acids on lipoxygenase more thoroughly, we have synthesized a novel inhibitor to lipoxygenase, (Z)-9-octadecenyl sulfate (oleyl sulfate, OS), which imparts kinetic properties that are inconsistent with simple competitive inhibition for both SLO-1 and 15-HLO.	Oleyl sulfate	168-181	linoleate 9S-lipoxygenase-4	Glycine max	56-68
10769137-3	2000	To investigate the inhibitory effects of fatty acids on lipoxygenase more thoroughly, we have synthesized a novel inhibitor to lipoxygenase, (Z)-9-octadecenyl sulfate (oleyl sulfate, OS), which imparts kinetic properties that are inconsistent with simple competitive inhibition for both SLO-1 and 15-HLO.	Oleyl sulfate	168-181	linoleate 9S-lipoxygenase-4	Glycine max	127-139
10769137-3	2000	To investigate the inhibitory effects of fatty acids on lipoxygenase more thoroughly, we have synthesized a novel inhibitor to lipoxygenase, (Z)-9-octadecenyl sulfate (oleyl sulfate, OS), which imparts kinetic properties that are inconsistent with simple competitive inhibition for both SLO-1 and 15-HLO.	Osmium	183-185	linoleate 9S-lipoxygenase-4	Glycine max	56-68
10704209-1	2000	Previous work has demonstrated that the ferric form of soybean lipoxygenase-1 will catalyze an elimination reaction on 12-iodo-cis-9-octadecenoic acid (12-IODE) to produce 9, 11-octadecadienoic acid and iodide ion.	Ferric enterobactin ion	40-46	linoleate 9S-lipoxygenase-4	Glycine max	63-75
10830513-5	2000	Compounds 1, 4 ((9Z, 12Z, 14E)-16-hydroxy-9,12,14-octadecatrienoic acid), 5 and 6 also showed inhibitory activity toward soybean lipoxygenase at a concentration of 10 microg/ml.	9z, 12z, 14e)-16-hydroxy-9,12,14-octadecatrienoic acid	17-71	linoleate 9S-lipoxygenase-4	Glycine max	129-141
10727939-0	2000	Formation of a new class of oxylipins from N-acyl(ethanol)amines by the lipoxygenase pathway.	Oxylipins	28-37	linoleate 9S-lipoxygenase-4	Glycine max	72-84
10727939-0	2000	Formation of a new class of oxylipins from N-acyl(ethanol)amines by the lipoxygenase pathway.	N-acylethanolamines	43-64	linoleate 9S-lipoxygenase-4	Glycine max	72-84
10727939-4	2000	We tested whether members of the NAE class can be converted by enzymes constituting this pathway, such as (soybean) lipoxygenase-1, (alfalfa) hydroperoxide lyase and (flax seed) allene oxide synthase.	N-acylethanolamines	33-36	linoleate 9S-lipoxygenase-4	Glycine max	116-128
10727939-5	2000	We found that both alpha-N-linolenoylethanolamine and gamma-N-linolenoylethanolamine (18:3), as well as alpha-N-linolenoylamine and gamma-N-linolenoylamine were converted into their (13S)-hydroperoxide derivatives by lipoxygenase.	alpha-n-linolenoylethanolamine	19-49	linoleate 9S-lipoxygenase-4	Glycine max	217-229
10727939-5	2000	We found that both alpha-N-linolenoylethanolamine and gamma-N-linolenoylethanolamine (18:3), as well as alpha-N-linolenoylamine and gamma-N-linolenoylamine were converted into their (13S)-hydroperoxide derivatives by lipoxygenase.	gamma-n-linolenoylethanolamine	54-84	linoleate 9S-lipoxygenase-4	Glycine max	217-229
10727939-5	2000	We found that both alpha-N-linolenoylethanolamine and gamma-N-linolenoylethanolamine (18:3), as well as alpha-N-linolenoylamine and gamma-N-linolenoylamine were converted into their (13S)-hydroperoxide derivatives by lipoxygenase.	alpha-n-linolenoylamine	104-127	linoleate 9S-lipoxygenase-4	Glycine max	217-229
10727939-5	2000	We found that both alpha-N-linolenoylethanolamine and gamma-N-linolenoylethanolamine (18:3), as well as alpha-N-linolenoylamine and gamma-N-linolenoylamine were converted into their (13S)-hydroperoxide derivatives by lipoxygenase.	gamma-n-linolenoylamine	132-155	linoleate 9S-lipoxygenase-4	Glycine max	217-229
10727939-5	2000	We found that both alpha-N-linolenoylethanolamine and gamma-N-linolenoylethanolamine (18:3), as well as alpha-N-linolenoylamine and gamma-N-linolenoylamine were converted into their (13S)-hydroperoxide derivatives by lipoxygenase.	(13s)-hydroperoxide	182-201	linoleate 9S-lipoxygenase-4	Glycine max	217-229
10727939-9	2000	Kinetic studies with lipoxygenase and hydroperoxide lyase revealed that the fatty acid ethanolamides were converted as readily or even better than the corresponding free fatty acids.	Fatty Acids	76-86	linoleate 9S-lipoxygenase-4	Glycine max	21-33
10727939-9	2000	Kinetic studies with lipoxygenase and hydroperoxide lyase revealed that the fatty acid ethanolamides were converted as readily or even better than the corresponding free fatty acids.	ethanolamides	87-100	linoleate 9S-lipoxygenase-4	Glycine max	21-33
10727939-9	2000	Kinetic studies with lipoxygenase and hydroperoxide lyase revealed that the fatty acid ethanolamides were converted as readily or even better than the corresponding free fatty acids.	Fatty Acids, Nonesterified	165-181	linoleate 9S-lipoxygenase-4	Glycine max	21-33
10704209-1	2000	Previous work has demonstrated that the ferric form of soybean lipoxygenase-1 will catalyze an elimination reaction on 12-iodo-cis-9-octadecenoic acid (12-IODE) to produce 9, 11-octadecadienoic acid and iodide ion.	12-Iodo-9-octadecenoic acid	119-150	linoleate 9S-lipoxygenase-4	Glycine max	63-75
10704209-1	2000	Previous work has demonstrated that the ferric form of soybean lipoxygenase-1 will catalyze an elimination reaction on 12-iodo-cis-9-octadecenoic acid (12-IODE) to produce 9, 11-octadecadienoic acid and iodide ion.	12-Iodo-9-octadecenoic acid	152-159	linoleate 9S-lipoxygenase-4	Glycine max	63-75
10704209-1	2000	Previous work has demonstrated that the ferric form of soybean lipoxygenase-1 will catalyze an elimination reaction on 12-iodo-cis-9-octadecenoic acid (12-IODE) to produce 9, 11-octadecadienoic acid and iodide ion.	9,11-linoleic acid	172-198	linoleate 9S-lipoxygenase-4	Glycine max	63-75
10704209-1	2000	Previous work has demonstrated that the ferric form of soybean lipoxygenase-1 will catalyze an elimination reaction on 12-iodo-cis-9-octadecenoic acid (12-IODE) to produce 9, 11-octadecadienoic acid and iodide ion.	Iodides	203-209	linoleate 9S-lipoxygenase-4	Glycine max	63-75
10704209-5	2000	ESR spectroscopy was used to demonstrate that 12-IODE can reduce ferric lipoxygenase to the ferrous form, and a large isotope effect on this process was observed with D(2)-12-IODE.	12-Iodo-9-octadecenoic acid	46-53	linoleate 9S-lipoxygenase-4	Glycine max	72-84
10704209-5	2000	ESR spectroscopy was used to demonstrate that 12-IODE can reduce ferric lipoxygenase to the ferrous form, and a large isotope effect on this process was observed with D(2)-12-IODE.	d(2)-12-iode	167-179	linoleate 9S-lipoxygenase-4	Glycine max	72-84
10643870-0	2000	Lipoxygenase-mediated biotransformation of p-aminophenol in the presence of glutathione: possible conjugate formation.	4-aminophenol	43-56	linoleate 9S-lipoxygenase-4	Glycine max	0-12
10643870-0	2000	Lipoxygenase-mediated biotransformation of p-aminophenol in the presence of glutathione: possible conjugate formation.	Glutathione	76-87	linoleate 9S-lipoxygenase-4	Glycine max	0-12
10643870-1	2000	This study tested a hypothesis that soybean lipoxygenase (SLO), a model enzyme, may be capable of generating a glutathione (GSH) conjugate(s) from p-aminophenol (PAP).	Glutathione	111-122	linoleate 9S-lipoxygenase-4	Glycine max	44-56
10643870-1	2000	This study tested a hypothesis that soybean lipoxygenase (SLO), a model enzyme, may be capable of generating a glutathione (GSH) conjugate(s) from p-aminophenol (PAP).	Glutathione	124-127	linoleate 9S-lipoxygenase-4	Glycine max	44-56
10643870-1	2000	This study tested a hypothesis that soybean lipoxygenase (SLO), a model enzyme, may be capable of generating a glutathione (GSH) conjugate(s) from p-aminophenol (PAP).	4-aminophenol	147-160	linoleate 9S-lipoxygenase-4	Glycine max	44-56
10643870-1	2000	This study tested a hypothesis that soybean lipoxygenase (SLO), a model enzyme, may be capable of generating a glutathione (GSH) conjugate(s) from p-aminophenol (PAP).	4-aminophenol	162-165	linoleate 9S-lipoxygenase-4	Glycine max	44-56
10643870-5	2000	Classical inhibitors of lipoxygenase and free radical scavengers markedly decreased the rate of GS-PAP formation in a concentration-dependent manner.	gs-pap	96-102	linoleate 9S-lipoxygenase-4	Glycine max	24-36
10643870-7	2000	Collectively, the results suggest that lipoxygenase pathway may be involved in the enzymatic formation of GSH conjugate(s) from PAP.	Glutathione	106-109	linoleate 9S-lipoxygenase-4	Glycine max	39-51
10874469-3	2000	Effects of 15-lipoxygenase on the hydrolysis of adenosine 5"-triphosphate were investigated in vitro using soybean lipoxygenase and adenosine 5"-[gamma-32P]triphosphate.	Adenosine Triphosphate	48-73	linoleate 9S-lipoxygenase-4	Glycine max	14-26
10874469-7	2000	These findings suggest that soybean lipoxygenase catalyzes the release of inorganic phosphate from ATP primarily via hydrolysis.	Phosphates	74-93	linoleate 9S-lipoxygenase-4	Glycine max	36-48
10874469-7	2000	These findings suggest that soybean lipoxygenase catalyzes the release of inorganic phosphate from ATP primarily via hydrolysis.	Adenosine Triphosphate	99-102	linoleate 9S-lipoxygenase-4	Glycine max	36-48
10910470-2	2000	"Shuttle Oxidant" effect of lipoxygenase-generated radical of chlorpromazine and related phenothiazines on the oxidation of benzidine and other xenobiotics.	Chlorpromazine	62-76	linoleate 9S-lipoxygenase-4	Glycine max	28-40
10910470-2	2000	"Shuttle Oxidant" effect of lipoxygenase-generated radical of chlorpromazine and related phenothiazines on the oxidation of benzidine and other xenobiotics.	Phenothiazines	89-103	linoleate 9S-lipoxygenase-4	Glycine max	28-40
10910470-2	2000	"Shuttle Oxidant" effect of lipoxygenase-generated radical of chlorpromazine and related phenothiazines on the oxidation of benzidine and other xenobiotics.	benzidine	124-133	linoleate 9S-lipoxygenase-4	Glycine max	28-40
10910470-5	2000	To evaluate the hypothesis, we investigated the metabolic interaction of two well-known substrates, chlorpromazine and benzidine, which have been shown to be oxidized by soybean lipoxygenase in the presence of hydrogen peroxide.	Chlorpromazine	100-114	linoleate 9S-lipoxygenase-4	Glycine max	178-190
10910470-5	2000	To evaluate the hypothesis, we investigated the metabolic interaction of two well-known substrates, chlorpromazine and benzidine, which have been shown to be oxidized by soybean lipoxygenase in the presence of hydrogen peroxide.	benzidine	119-128	linoleate 9S-lipoxygenase-4	Glycine max	178-190
10910470-5	2000	To evaluate the hypothesis, we investigated the metabolic interaction of two well-known substrates, chlorpromazine and benzidine, which have been shown to be oxidized by soybean lipoxygenase in the presence of hydrogen peroxide.	Hydrogen Peroxide	210-227	linoleate 9S-lipoxygenase-4	Glycine max	178-190
10910470-6	2000	The evidence presented here clearly indicates that the chlorpromazine cation radical generated by the lipoxygenase triggers a rapid oxidation of benzidine to benzidine diimine.	Chlorpromazine	55-84	linoleate 9S-lipoxygenase-4	Glycine max	102-114
10910470-6	2000	The evidence presented here clearly indicates that the chlorpromazine cation radical generated by the lipoxygenase triggers a rapid oxidation of benzidine to benzidine diimine.	benzidine	145-154	linoleate 9S-lipoxygenase-4	Glycine max	102-114
10910470-6	2000	The evidence presented here clearly indicates that the chlorpromazine cation radical generated by the lipoxygenase triggers a rapid oxidation of benzidine to benzidine diimine.	benzidine-4,4'-diimine	158-175	linoleate 9S-lipoxygenase-4	Glycine max	102-114
10910470-12	2000	Preliminary data suggest that purified human term placental lipoxygenase also displays a similar stimulatory response in the benzidine oxidation in the presence of chlorpromazine.	benzidine	125-134	linoleate 9S-lipoxygenase-4	Glycine max	60-72
10910470-12	2000	Preliminary data suggest that purified human term placental lipoxygenase also displays a similar stimulatory response in the benzidine oxidation in the presence of chlorpromazine.	Chlorpromazine	164-178	linoleate 9S-lipoxygenase-4	Glycine max	60-72
10552543-1	1999	Lipoxygenase activity in olive fruits increases considerably when the enzyme is extracted using extraction buffer with ethylenediaminetetraacetate, Triton X-100, dithiothreitol, sodium meta-bisulfite, and hydrated polyvinylpolypyrrolidone.	Edetic Acid	119-146	linoleate 9S-lipoxygenase-4	Glycine max	0-12
10606550-1	1999	A number of products including apocarotenal, epoxycarotenal, apocarotenone, and epoxycarotenone generated by lipoxygenase (LOX) catalyzed co-oxidation of beta-carotene have been tentatively identified through the use of GC/MS and HPLC combined with photodiode array detection.	apocarotenal	31-43	linoleate 9S-lipoxygenase-4	Glycine max	109-121
10606550-1	1999	A number of products including apocarotenal, epoxycarotenal, apocarotenone, and epoxycarotenone generated by lipoxygenase (LOX) catalyzed co-oxidation of beta-carotene have been tentatively identified through the use of GC/MS and HPLC combined with photodiode array detection.	apocarotenal	31-43	linoleate 9S-lipoxygenase-4	Glycine max	123-126
10606550-1	1999	A number of products including apocarotenal, epoxycarotenal, apocarotenone, and epoxycarotenone generated by lipoxygenase (LOX) catalyzed co-oxidation of beta-carotene have been tentatively identified through the use of GC/MS and HPLC combined with photodiode array detection.	epoxycarotenal	45-59	linoleate 9S-lipoxygenase-4	Glycine max	109-121
10606550-1	1999	A number of products including apocarotenal, epoxycarotenal, apocarotenone, and epoxycarotenone generated by lipoxygenase (LOX) catalyzed co-oxidation of beta-carotene have been tentatively identified through the use of GC/MS and HPLC combined with photodiode array detection.	epoxycarotenal	45-59	linoleate 9S-lipoxygenase-4	Glycine max	123-126
10606550-1	1999	A number of products including apocarotenal, epoxycarotenal, apocarotenone, and epoxycarotenone generated by lipoxygenase (LOX) catalyzed co-oxidation of beta-carotene have been tentatively identified through the use of GC/MS and HPLC combined with photodiode array detection.	apocarotenone	61-74	linoleate 9S-lipoxygenase-4	Glycine max	109-121
10606550-1	1999	A number of products including apocarotenal, epoxycarotenal, apocarotenone, and epoxycarotenone generated by lipoxygenase (LOX) catalyzed co-oxidation of beta-carotene have been tentatively identified through the use of GC/MS and HPLC combined with photodiode array detection.	apocarotenone	61-74	linoleate 9S-lipoxygenase-4	Glycine max	123-126
10606550-1	1999	A number of products including apocarotenal, epoxycarotenal, apocarotenone, and epoxycarotenone generated by lipoxygenase (LOX) catalyzed co-oxidation of beta-carotene have been tentatively identified through the use of GC/MS and HPLC combined with photodiode array detection.	epoxycarotenone	80-95	linoleate 9S-lipoxygenase-4	Glycine max	109-121
10606550-1	1999	A number of products including apocarotenal, epoxycarotenal, apocarotenone, and epoxycarotenone generated by lipoxygenase (LOX) catalyzed co-oxidation of beta-carotene have been tentatively identified through the use of GC/MS and HPLC combined with photodiode array detection.	epoxycarotenone	80-95	linoleate 9S-lipoxygenase-4	Glycine max	123-126
10606550-1	1999	A number of products including apocarotenal, epoxycarotenal, apocarotenone, and epoxycarotenone generated by lipoxygenase (LOX) catalyzed co-oxidation of beta-carotene have been tentatively identified through the use of GC/MS and HPLC combined with photodiode array detection.	beta Carotene	154-167	linoleate 9S-lipoxygenase-4	Glycine max	109-121
10606550-1	1999	A number of products including apocarotenal, epoxycarotenal, apocarotenone, and epoxycarotenone generated by lipoxygenase (LOX) catalyzed co-oxidation of beta-carotene have been tentatively identified through the use of GC/MS and HPLC combined with photodiode array detection.	beta Carotene	154-167	linoleate 9S-lipoxygenase-4	Glycine max	123-126
10606550-2	1999	Because of the large number of high molecular weight products detected and their probable chemical structures, a co-oxidation mechanism is proposed that involves random attack along the alkene chain of the carotenoid by a LOX-generated linoleoylperoxyl radical.	Alkenes	186-192	linoleate 9S-lipoxygenase-4	Glycine max	222-225
10606550-2	1999	Because of the large number of high molecular weight products detected and their probable chemical structures, a co-oxidation mechanism is proposed that involves random attack along the alkene chain of the carotenoid by a LOX-generated linoleoylperoxyl radical.	Carotenoids	206-216	linoleate 9S-lipoxygenase-4	Glycine max	222-225
10606550-2	1999	Because of the large number of high molecular weight products detected and their probable chemical structures, a co-oxidation mechanism is proposed that involves random attack along the alkene chain of the carotenoid by a LOX-generated linoleoylperoxyl radical.	linoleoylperoxyl radical	236-260	linoleate 9S-lipoxygenase-4	Glycine max	222-225
10606550-3	1999	It is suggested that a direct release from the enzyme of the radical, which initiates the co-oxidation of beta-carotene, is greater for pea LOX-3 than for pea LOX-2 or soybean LOX-1.	beta Carotene	106-119	linoleate 9S-lipoxygenase-4	Glycine max	140-143
10737223-0	1999	Effects of ascorbic acid on peroxidation of human erythrocyte membranes by lipoxygenase.	Ascorbic Acid	11-24	linoleate 9S-lipoxygenase-4	Glycine max	75-87
10737223-1	1999	The effects of ascorbic acid (AsA) on membrane phospholipids (PLs) and tocopherols (Tocs) of human erythrocyte during peroxidation by soybean lipoxygenase (LOX) were investigated.	Ascorbic Acid	15-28	linoleate 9S-lipoxygenase-4	Glycine max	142-154
10737223-1	1999	The effects of ascorbic acid (AsA) on membrane phospholipids (PLs) and tocopherols (Tocs) of human erythrocyte during peroxidation by soybean lipoxygenase (LOX) were investigated.	Ascorbic Acid	30-33	linoleate 9S-lipoxygenase-4	Glycine max	142-154
10737223-1	1999	The effects of ascorbic acid (AsA) on membrane phospholipids (PLs) and tocopherols (Tocs) of human erythrocyte during peroxidation by soybean lipoxygenase (LOX) were investigated.	Tocopherols	71-82	linoleate 9S-lipoxygenase-4	Glycine max	142-154
10737223-5	1999	Control incubation without LOX and AsA was done for 45 min at 30 degrees C. After the incubation with LOX, alpha- and gamma-Tocs were exhausted, PLs decreased, and PL-OOHs and malondialdehyde (MDA) increased.	Ascorbic Acid	35-38	linoleate 9S-lipoxygenase-4	Glycine max	102-105
10737223-7	1999	Subsequent incubation with AsA for 45 min after the incubation with LOX (after Tocs were exhausted) showed a 240% increase in MDA, but it decreased PLs by only about 15% of the preincubation values and recovered gamma-Toc to about 13% of the control.	Ascorbic Acid	27-30	linoleate 9S-lipoxygenase-4	Glycine max	68-71
10737223-7	1999	Subsequent incubation with AsA for 45 min after the incubation with LOX (after Tocs were exhausted) showed a 240% increase in MDA, but it decreased PLs by only about 15% of the preincubation values and recovered gamma-Toc to about 13% of the control.	gamma-Tocopherol	212-221	linoleate 9S-lipoxygenase-4	Glycine max	68-71
10602300-3	1999	The reactivity of lipoxygenase with peroxides in the gallic acid solidus hydroperoxide system was in the order of methylethyl hydroperoxide (MEK-OOH, 4800 cps) > tert-butyl hydroperoxide (tert-BuOOH, 607 cps) > hydrogen peroxide (H(2)O(2), 455 cps) > cumene hydroperoxide (cumene-OOH, 261 cps).	Peroxides	36-45	linoleate 9S-lipoxygenase-4	Glycine max	18-30
10602300-3	1999	The reactivity of lipoxygenase with peroxides in the gallic acid solidus hydroperoxide system was in the order of methylethyl hydroperoxide (MEK-OOH, 4800 cps) > tert-butyl hydroperoxide (tert-BuOOH, 607 cps) > hydrogen peroxide (H(2)O(2), 455 cps) > cumene hydroperoxide (cumene-OOH, 261 cps).	Gallic Acid	53-64	linoleate 9S-lipoxygenase-4	Glycine max	18-30
10602300-3	1999	The reactivity of lipoxygenase with peroxides in the gallic acid solidus hydroperoxide system was in the order of methylethyl hydroperoxide (MEK-OOH, 4800 cps) > tert-butyl hydroperoxide (tert-BuOOH, 607 cps) > hydrogen peroxide (H(2)O(2), 455 cps) > cumene hydroperoxide (cumene-OOH, 261 cps).	Hydrogen Peroxide	73-86	linoleate 9S-lipoxygenase-4	Glycine max	18-30
10602300-3	1999	The reactivity of lipoxygenase with peroxides in the gallic acid solidus hydroperoxide system was in the order of methylethyl hydroperoxide (MEK-OOH, 4800 cps) > tert-butyl hydroperoxide (tert-BuOOH, 607 cps) > hydrogen peroxide (H(2)O(2), 455 cps) > cumene hydroperoxide (cumene-OOH, 261 cps).	methylethyl hydroperoxide	114-139	linoleate 9S-lipoxygenase-4	Glycine max	18-30
10602300-3	1999	The reactivity of lipoxygenase with peroxides in the gallic acid solidus hydroperoxide system was in the order of methylethyl hydroperoxide (MEK-OOH, 4800 cps) > tert-butyl hydroperoxide (tert-BuOOH, 607 cps) > hydrogen peroxide (H(2)O(2), 455 cps) > cumene hydroperoxide (cumene-OOH, 261 cps).	OOH	145-148	linoleate 9S-lipoxygenase-4	Glycine max	18-30
10602300-3	1999	The reactivity of lipoxygenase with peroxides in the gallic acid solidus hydroperoxide system was in the order of methylethyl hydroperoxide (MEK-OOH, 4800 cps) > tert-butyl hydroperoxide (tert-BuOOH, 607 cps) > hydrogen peroxide (H(2)O(2), 455 cps) > cumene hydroperoxide (cumene-OOH, 261 cps).	tert-Butylhydroperoxide	165-189	linoleate 9S-lipoxygenase-4	Glycine max	18-30
10602300-3	1999	The reactivity of lipoxygenase with peroxides in the gallic acid solidus hydroperoxide system was in the order of methylethyl hydroperoxide (MEK-OOH, 4800 cps) > tert-butyl hydroperoxide (tert-BuOOH, 607 cps) > hydrogen peroxide (H(2)O(2), 455 cps) > cumene hydroperoxide (cumene-OOH, 261 cps).	tert-Butylhydroperoxide	191-201	linoleate 9S-lipoxygenase-4	Glycine max	18-30
10602300-3	1999	The reactivity of lipoxygenase with peroxides in the gallic acid solidus hydroperoxide system was in the order of methylethyl hydroperoxide (MEK-OOH, 4800 cps) > tert-butyl hydroperoxide (tert-BuOOH, 607 cps) > hydrogen peroxide (H(2)O(2), 455 cps) > cumene hydroperoxide (cumene-OOH, 261 cps).	Hydrogen Peroxide	217-234	linoleate 9S-lipoxygenase-4	Glycine max	18-30
10602300-3	1999	The reactivity of lipoxygenase with peroxides in the gallic acid solidus hydroperoxide system was in the order of methylethyl hydroperoxide (MEK-OOH, 4800 cps) > tert-butyl hydroperoxide (tert-BuOOH, 607 cps) > hydrogen peroxide (H(2)O(2), 455 cps) > cumene hydroperoxide (cumene-OOH, 261 cps).	Hydrogen	236-240	linoleate 9S-lipoxygenase-4	Glycine max	18-30
10602300-3	1999	The reactivity of lipoxygenase with peroxides in the gallic acid solidus hydroperoxide system was in the order of methylethyl hydroperoxide (MEK-OOH, 4800 cps) > tert-butyl hydroperoxide (tert-BuOOH, 607 cps) > hydrogen peroxide (H(2)O(2), 455 cps) > cumene hydroperoxide (cumene-OOH, 261 cps).	cumene hydroperoxide	260-280	linoleate 9S-lipoxygenase-4	Glycine max	18-30
10602300-3	1999	The reactivity of lipoxygenase with peroxides in the gallic acid solidus hydroperoxide system was in the order of methylethyl hydroperoxide (MEK-OOH, 4800 cps) > tert-butyl hydroperoxide (tert-BuOOH, 607 cps) > hydrogen peroxide (H(2)O(2), 455 cps) > cumene hydroperoxide (cumene-OOH, 261 cps).	cumene	260-266	linoleate 9S-lipoxygenase-4	Glycine max	18-30
10602300-3	1999	The reactivity of lipoxygenase with peroxides in the gallic acid solidus hydroperoxide system was in the order of methylethyl hydroperoxide (MEK-OOH, 4800 cps) > tert-butyl hydroperoxide (tert-BuOOH, 607 cps) > hydrogen peroxide (H(2)O(2), 455 cps) > cumene hydroperoxide (cumene-OOH, 261 cps).	OOH	198-201	linoleate 9S-lipoxygenase-4	Glycine max	18-30
10602300-5	1999	The photon intensity from the gallic acid lipoxygenase system corresponded to the linoleic acid hydroperoxide value.	linoleic acid hydroperoxide	82-109	linoleate 9S-lipoxygenase-4	Glycine max	42-54
16429610-0	1999	Exploring surfaces and cavities in lipoxygenase and other proteins by hyperpolarized xenon-129 NMR.	Xenon	85-90	linoleate 9S-lipoxygenase-4	Glycine max	35-47
10558895-0	1999	The use of fluorescein 5"-isothiocyanate for studies of structural and molecular mechanisms of soybean lipoxygenase.	Fluorescein-5-isothiocyanate	11-40	linoleate 9S-lipoxygenase-4	Glycine max	103-115
10558895-1	1999	Incubation of fluorescein 5"-isothiocyanate (FITC) with soybean lipoxygenase produces the coupling of 1 mol of fluorophore to 1 mol of enzyme.	Fluorescein-5-isothiocyanate	14-43	linoleate 9S-lipoxygenase-4	Glycine max	64-76
10558895-1	1999	Incubation of fluorescein 5"-isothiocyanate (FITC) with soybean lipoxygenase produces the coupling of 1 mol of fluorophore to 1 mol of enzyme.	Fluorescein-5-isothiocyanate	45-49	linoleate 9S-lipoxygenase-4	Glycine max	64-76
10558895-3	1999	The quenching by IK of the fluorescence of FITC-labeled lipoxygenase shows that the fluorophore is located near the surface of the protein.	Fluorescein-5-isothiocyanate	43-47	linoleate 9S-lipoxygenase-4	Glycine max	56-68
10558895-6	1999	The results obtained strongly suggest that FITC labels soybean lipoxygenase specifically at a lysyl residue which contributes to fixation of the carboxylic end of the substrate to the active center.	Fluorescein-5-isothiocyanate	43-47	linoleate 9S-lipoxygenase-4	Glycine max	63-75
10432202-3	1999	Flavonoids extracted from pcpso showed 31-44% inhibition of sheep cyclooxygenase and 69-81% inhibition of soybean lipoxygenase.	Flavonoids	0-10	linoleate 9S-lipoxygenase-4	Glycine max	114-126
10432202-4	1999	Flavonoids extracted from pfj showed 21-30% inhibition of soybean lipoxygenase though no significant inhibition of sheep cyclooxygenase.	Flavonoids	0-10	linoleate 9S-lipoxygenase-4	Glycine max	66-78
10552543-1	1999	Lipoxygenase activity in olive fruits increases considerably when the enzyme is extracted using extraction buffer with ethylenediaminetetraacetate, Triton X-100, dithiothreitol, sodium meta-bisulfite, and hydrated polyvinylpolypyrrolidone.	Octoxynol	148-160	linoleate 9S-lipoxygenase-4	Glycine max	0-12
10552543-1	1999	Lipoxygenase activity in olive fruits increases considerably when the enzyme is extracted using extraction buffer with ethylenediaminetetraacetate, Triton X-100, dithiothreitol, sodium meta-bisulfite, and hydrated polyvinylpolypyrrolidone.	Dithiothreitol	162-176	linoleate 9S-lipoxygenase-4	Glycine max	0-12
10432202-4	1999	Flavonoids extracted from pfj showed 21-30% inhibition of soybean lipoxygenase though no significant inhibition of sheep cyclooxygenase.	PQ-10	26-29	linoleate 9S-lipoxygenase-4	Glycine max	66-78
10552543-1	1999	Lipoxygenase activity in olive fruits increases considerably when the enzyme is extracted using extraction buffer with ethylenediaminetetraacetate, Triton X-100, dithiothreitol, sodium meta-bisulfite, and hydrated polyvinylpolypyrrolidone.	sodium metabisulfite	178-199	linoleate 9S-lipoxygenase-4	Glycine max	0-12
10552543-1	1999	Lipoxygenase activity in olive fruits increases considerably when the enzyme is extracted using extraction buffer with ethylenediaminetetraacetate, Triton X-100, dithiothreitol, sodium meta-bisulfite, and hydrated polyvinylpolypyrrolidone.	polyvinylpolypyrrolidone	214-238	linoleate 9S-lipoxygenase-4	Glycine max	0-12
10552543-3	1999	Moreover, when the oxidizing level of the medium is increased by the addition of linoleic acid or soybean lipoxygenase with linoleic acid, the crude enzymatic extracts of olives reduce the destructive capacity of soybean lipoxygenase on chlorophylls to one-sixth.	Linoleic Acid	81-94	linoleate 9S-lipoxygenase-4	Glycine max	221-233
10552543-3	1999	Moreover, when the oxidizing level of the medium is increased by the addition of linoleic acid or soybean lipoxygenase with linoleic acid, the crude enzymatic extracts of olives reduce the destructive capacity of soybean lipoxygenase on chlorophylls to one-sixth.	Linoleic Acid	124-137	linoleate 9S-lipoxygenase-4	Glycine max	106-118
10552543-3	1999	Moreover, when the oxidizing level of the medium is increased by the addition of linoleic acid or soybean lipoxygenase with linoleic acid, the crude enzymatic extracts of olives reduce the destructive capacity of soybean lipoxygenase on chlorophylls to one-sixth.	Linoleic Acid	124-137	linoleate 9S-lipoxygenase-4	Glycine max	221-233
10552543-3	1999	Moreover, when the oxidizing level of the medium is increased by the addition of linoleic acid or soybean lipoxygenase with linoleic acid, the crude enzymatic extracts of olives reduce the destructive capacity of soybean lipoxygenase on chlorophylls to one-sixth.	Chlorophyll	237-249	linoleate 9S-lipoxygenase-4	Glycine max	106-118
10552543-4	1999	These results suggest a double pigment protection against lipoxygenase in the olive crude extract, one inhibiting the enzyme and the other interrupting the chain of oxidative reactions beginning with hydroperoxide formation.	Hydrogen Peroxide	200-213	linoleate 9S-lipoxygenase-4	Glycine max	58-70
10379845-0	1999	N-demethylation of phenothiazines by lipoxygenase from soybean and human term placenta in the presence of hydrogen peroxide.	Phenothiazines	19-33	linoleate 9S-lipoxygenase-4	Glycine max	37-49
10794652-1	1999	Soybean lipoxygenase (LOX) inactivation [0.4 mg/mL in Tris-HCl buffer (0.01 M, pH 9)] was studied quantitatively under constant pressure (up to 650 MPa) and temperature (-15 to 68 degrees C) conditions and kinetically characterized by rate constants, activation energies, and activation volumes.	Tris hydrochloride	54-62	linoleate 9S-lipoxygenase-4	Glycine max	22-25
10418336-0	1999	A new phenolic fatty acid ester with lipoxygenase inhibitory activity from Jacaranda filicifolia.	phenolic fatty acid ester	6-31	linoleate 9S-lipoxygenase-4	Glycine max	37-49
9922163-0	1998	Structural and thermochemical characterization of lipoxygenase-catechol complexes.	catechol	63-71	linoleate 9S-lipoxygenase-4	Glycine max	50-62
9922163-1	1998	A complex between native, iron(II) soybean lipoxygenase 3 and 4-nitrocatechol, a known inhibitor of the enzyme, has been detected by isothermal titration calorimetry and characterized by X-ray crystallography.	Ferrosoferric Oxide	26-33	linoleate 9S-lipoxygenase-4	Glycine max	43-55
9922163-1	1998	A complex between native, iron(II) soybean lipoxygenase 3 and 4-nitrocatechol, a known inhibitor of the enzyme, has been detected by isothermal titration calorimetry and characterized by X-ray crystallography.	4-nitrocatechol	62-77	linoleate 9S-lipoxygenase-4	Glycine max	43-55
9922163-6	1998	These observations reveal specific details of the interaction between lipoxygenase and a small molecule and raise the possibility that changes in the ligand environment of the iron atom could be a feature of the product activation reaction or the catalytic mechanism.	Iron	160-164	linoleate 9S-lipoxygenase-4	Glycine max	70-82
9990451-0	1999	New minimal substrate structural requirements in the enzymatic peroxidation of alkenes with soybean lipoxygenase.	Alkenes	79-86	linoleate 9S-lipoxygenase-4	Glycine max	100-112
10379845-0	1999	N-demethylation of phenothiazines by lipoxygenase from soybean and human term placenta in the presence of hydrogen peroxide.	Hydrogen Peroxide	106-123	linoleate 9S-lipoxygenase-4	Glycine max	37-49
10379845-3	1999	In this study, we investigated hydrogen peroxide-dependent oxidation of six phenothiazines by purified lipoxygenase from soybean (SLO) and human term placenta (HTPLO).	Hydrogen Peroxide	31-48	linoleate 9S-lipoxygenase-4	Glycine max	103-115
10379845-3	1999	In this study, we investigated hydrogen peroxide-dependent oxidation of six phenothiazines by purified lipoxygenase from soybean (SLO) and human term placenta (HTPLO).	Phenothiazines	76-90	linoleate 9S-lipoxygenase-4	Glycine max	103-115
10379845-15	1999	The evidence gathered in this in vitro study suggests that phenothiazines can undergo peroxidative N-demethylation via lipoxygenase pathway.	Phenothiazines	59-73	linoleate 9S-lipoxygenase-4	Glycine max	119-131
9693089-0	1998	Characterization of soybean lipoxygenase immobilized in cross-linked phyllosilicates.	phyllosilicates	69-84	linoleate 9S-lipoxygenase-4	Glycine max	28-40
9784195-1	1998	A new high-performance liquid chromatography (HPLC) for separation of phospholipid classes with ultraviolet (UV) detection at 210 nm was applied to study of peroxidation of the human erythrocyte membranes induced by soybean lipoxygenase.	Phospholipids	70-82	linoleate 9S-lipoxygenase-4	Glycine max	224-236
9784195-4	1998	All phospholipid classes except sphingomyelin were significantly decreased by lipoxygenase.	Phospholipids	4-16	linoleate 9S-lipoxygenase-4	Glycine max	78-90
9784195-4	1998	All phospholipid classes except sphingomyelin were significantly decreased by lipoxygenase.	Sphingomyelins	32-45	linoleate 9S-lipoxygenase-4	Glycine max	78-90
9784195-6	1998	Polyunsaturated fatty acids of each phospholipid were preferentially decreased with lipoxygenase, and degrees of the changes of the phospholipid classes corresponded to the amount of polyunsaturated fatty acids of each phospholipid.	Fatty Acids, Unsaturated	0-27	linoleate 9S-lipoxygenase-4	Glycine max	84-96
9784195-6	1998	Polyunsaturated fatty acids of each phospholipid were preferentially decreased with lipoxygenase, and degrees of the changes of the phospholipid classes corresponded to the amount of polyunsaturated fatty acids of each phospholipid.	Phospholipids	36-48	linoleate 9S-lipoxygenase-4	Glycine max	84-96
9830005-3	1998	E-ring dinor isoprostane formation from linolenate was found to be catalyzed by soybean lipoxygenase.	e-ring dinor isoprostane	0-24	linoleate 9S-lipoxygenase-4	Glycine max	88-100
9830005-3	1998	E-ring dinor isoprostane formation from linolenate was found to be catalyzed by soybean lipoxygenase.	alpha-Linolenic Acid	40-50	linoleate 9S-lipoxygenase-4	Glycine max	88-100
9693089-1	1998	Lipoxygenase (LOX) is an enzyme that regioselectively introduces the hydroperoxide functionality into polyunsaturated fatty acids, such as linoleic acid (LA).	Hydrogen Peroxide	69-82	linoleate 9S-lipoxygenase-4	Glycine max	0-12
9693089-1	1998	Lipoxygenase (LOX) is an enzyme that regioselectively introduces the hydroperoxide functionality into polyunsaturated fatty acids, such as linoleic acid (LA).	Hydrogen Peroxide	69-82	linoleate 9S-lipoxygenase-4	Glycine max	14-17
9693089-1	1998	Lipoxygenase (LOX) is an enzyme that regioselectively introduces the hydroperoxide functionality into polyunsaturated fatty acids, such as linoleic acid (LA).	Fatty Acids, Unsaturated	102-129	linoleate 9S-lipoxygenase-4	Glycine max	0-12
9693089-1	1998	Lipoxygenase (LOX) is an enzyme that regioselectively introduces the hydroperoxide functionality into polyunsaturated fatty acids, such as linoleic acid (LA).	Fatty Acids, Unsaturated	102-129	linoleate 9S-lipoxygenase-4	Glycine max	14-17
9693089-1	1998	Lipoxygenase (LOX) is an enzyme that regioselectively introduces the hydroperoxide functionality into polyunsaturated fatty acids, such as linoleic acid (LA).	Linoleic Acid	139-152	linoleate 9S-lipoxygenase-4	Glycine max	0-12
9693089-1	1998	Lipoxygenase (LOX) is an enzyme that regioselectively introduces the hydroperoxide functionality into polyunsaturated fatty acids, such as linoleic acid (LA).	Linoleic Acid	139-152	linoleate 9S-lipoxygenase-4	Glycine max	14-17
9693089-3	1998	In this study, LOX was immobilized in dispersed phyllosilicate layers that were cross-linked with silicate polymers formed by the hydrolysis of tetramethyl orthosilicates.	phyllosilicate	48-62	linoleate 9S-lipoxygenase-4	Glycine max	15-18
9693089-3	1998	In this study, LOX was immobilized in dispersed phyllosilicate layers that were cross-linked with silicate polymers formed by the hydrolysis of tetramethyl orthosilicates.	Silicates	54-62	linoleate 9S-lipoxygenase-4	Glycine max	15-18
9693089-3	1998	In this study, LOX was immobilized in dispersed phyllosilicate layers that were cross-linked with silicate polymers formed by the hydrolysis of tetramethyl orthosilicates.	tetramethyl orthosilicate	144-170	linoleate 9S-lipoxygenase-4	Glycine max	15-18
9693089-8	1998	In general, LOX immobilized in cross-linked phyllosilicates retained the physical and chemical characteristics of free LOX.	phyllosilicates	44-59	linoleate 9S-lipoxygenase-4	Glycine max	12-15
9693089-8	1998	In general, LOX immobilized in cross-linked phyllosilicates retained the physical and chemical characteristics of free LOX.	phyllosilicates	44-59	linoleate 9S-lipoxygenase-4	Glycine max	119-122
9643019-5	1998	METHODS: (1) Lipid peroxides were formed by incubation of linoleic acid with lipoxygenase from soybean, separated by thin layer chromatography and incubated with tetramethylbenzidine.	Lipid Peroxides	13-28	linoleate 9S-lipoxygenase-4	Glycine max	77-89
9727603-0	1998	9-Hydroxy-traumatin, a new metabolite of the lipoxygenase pathway.	9-hydroxy-12-oxo-10(E)-dodecenoic acid	0-19	linoleate 9S-lipoxygenase-4	Glycine max	45-57
9689502-0	1998	Thiazolyl and benzothiazolyl Schiff bases as novel possible lipoxygenase inhibitors and anti inflammatory agents.	thiazolyl and benzothiazolyl schiff bases	0-41	linoleate 9S-lipoxygenase-4	Glycine max	60-72
9689502-2	1998	Several thiazolyl derivatives are reported to act as lipoxygenase inhibitors affecting inflammation and/or psoriasis.	thiazolyl	8-17	linoleate 9S-lipoxygenase-4	Glycine max	53-65
9643019-11	1998	(2) In the isolated retinae of pigs lipid peroxides became visible as electron-dense structures in the rod outer segments (ROS) after treatment with lipoxygenase and were lacking in the other parts of the retina.	Lipid Peroxides	36-51	linoleate 9S-lipoxygenase-4	Glycine max	149-161
9643019-12	1998	Without treatment with lipoxygenase lipid peroxides were only infrequently seen in ROS.	Lipid Peroxides	36-51	linoleate 9S-lipoxygenase-4	Glycine max	23-35
9643019-5	1998	METHODS: (1) Lipid peroxides were formed by incubation of linoleic acid with lipoxygenase from soybean, separated by thin layer chromatography and incubated with tetramethylbenzidine.	Linoleic Acid	58-71	linoleate 9S-lipoxygenase-4	Glycine max	77-89
9643019-6	1998	(2) Lipid peroxides were formed by incubation of porcine retinae with soybean lipoxygenase in an oxygensaturated atmosphere.	Lipid Peroxides	4-19	linoleate 9S-lipoxygenase-4	Glycine max	78-90
18574729-0	1998	Effectiveness of cross-linked phyllosilicates for intercalative immobilization of soybean lipoxygenase.	phyllosilicates	30-45	linoleate 9S-lipoxygenase-4	Glycine max	90-102
9497325-5	1998	Exposure of isolated HDL to either low fluxes of aqueous peroxyl radicals, Cu2+ ions, or soybean lipoxygenase resulted in the oxidation of apoAI and apoAII during the earliest stages of the reaction, i.e. after consumption of ubiquinol-10 and in the presence of alpha-TOH.	ubiquinol	226-235	linoleate 9S-lipoxygenase-4	Glycine max	97-109
9497325-5	1998	Exposure of isolated HDL to either low fluxes of aqueous peroxyl radicals, Cu2+ ions, or soybean lipoxygenase resulted in the oxidation of apoAI and apoAII during the earliest stages of the reaction, i.e. after consumption of ubiquinol-10 and in the presence of alpha-TOH.	alpha-Tocopherol	262-271	linoleate 9S-lipoxygenase-4	Glycine max	97-109
9497325-9	1998	Exposure of isolated apoAI to peroxyl radicals, Cu2+, or soybean lipoxygenase resulted in nonspecific (for peroxyl radicals) or no discernible protein oxidation (Cu2+ and soybean lipoxygenase).	perhydroxyl radical	30-46	linoleate 9S-lipoxygenase-4	Glycine max	179-191
9497325-9	1998	Exposure of isolated apoAI to peroxyl radicals, Cu2+, or soybean lipoxygenase resulted in nonspecific (for peroxyl radicals) or no discernible protein oxidation (Cu2+ and soybean lipoxygenase).	perhydroxyl radical	107-123	linoleate 9S-lipoxygenase-4	Glycine max	65-77
9497325-13	1998	alpha-TOH enrichment also enhanced HDL lipid and protein oxidation induced by Cu2+ or soybean lipoxygenase.	alpha-Tocopherol	0-9	linoleate 9S-lipoxygenase-4	Glycine max	94-106
9501125-0	1998	Specific soybean lipoxygenases localize to discrete subcellular compartments and their mRNAs are differentially regulated by source-sink status Members of the lipoxygenase multigene family, found widely in eukaryotes, have been proposed to function in nitrogen partitioning and storage in plants.	Nitrogen	253-261	linoleate 9S-lipoxygenase-4	Glycine max	160-172
9501125-8	1998	Specific lipoxygenase isoforms may have a role in short-term nitrogen storage (VLXC/D), whereas others may simultaneously function in assimilate partitioning as active enzymes (VLXA/B).	Nitrogen	62-70	linoleate 9S-lipoxygenase-4	Glycine max	10-22
18574729-2	1998	Lipoxygenase (LOX) intercalated into cross-linked phyllosilicates exhibited high enzymatic activity.	phyllosilicates	50-65	linoleate 9S-lipoxygenase-4	Glycine max	0-12
18574729-2	1998	Lipoxygenase (LOX) intercalated into cross-linked phyllosilicates exhibited high enzymatic activity.	phyllosilicates	50-65	linoleate 9S-lipoxygenase-4	Glycine max	14-17
18574729-4	1998	Alkylamines were used to occupy the charge sites of the phyllosilicate, which increased the hydrophobicity of the phyllosilicate and reduced charge-charge interaction between LOX and the phyllosilicate.	alkylamines	0-11	linoleate 9S-lipoxygenase-4	Glycine max	175-178
18574729-4	1998	Alkylamines were used to occupy the charge sites of the phyllosilicate, which increased the hydrophobicity of the phyllosilicate and reduced charge-charge interaction between LOX and the phyllosilicate.	phyllosilicate	56-70	linoleate 9S-lipoxygenase-4	Glycine max	175-178
18574729-5	1998	The amount of macropores and the enzymatic activity of the lipoxygenase-phyllosilicate composites increased with an increase in the ratio of trimethylammonium (TMA)-phyllosilicate to cross-linking reagent TMOS.	phyllosilicate	72-86	linoleate 9S-lipoxygenase-4	Glycine max	59-71
18574729-5	1998	The amount of macropores and the enzymatic activity of the lipoxygenase-phyllosilicate composites increased with an increase in the ratio of trimethylammonium (TMA)-phyllosilicate to cross-linking reagent TMOS.	Cetrimonium	141-158	linoleate 9S-lipoxygenase-4	Glycine max	59-71
18574729-5	1998	The amount of macropores and the enzymatic activity of the lipoxygenase-phyllosilicate composites increased with an increase in the ratio of trimethylammonium (TMA)-phyllosilicate to cross-linking reagent TMOS.	phyllosilicate	165-179	linoleate 9S-lipoxygenase-4	Glycine max	59-71
18574729-6	1998	LOX intercalatively immobilized into phyllosilicates displayed good storage stability and reusability at ambient temperature.	phyllosilicates	37-52	linoleate 9S-lipoxygenase-4	Glycine max	0-3
9335571-5	1997	Results from stopped-flow studies indicate that the hydroperoxide level influences the rate of Compound II formation indirectly, via changes in the transient accumulation of Compound I, rather than by reducing Compound I. PGHS and soybean lipoxygenase reactions with 11,14-eicosadienoic acid (20:2) were also analyzed using a spectrophotometer cuvette fitted with an oxygen electrode to monitor lipid product formation and oxygen consumption simultaneously.	Hydrogen Peroxide	52-65	linoleate 9S-lipoxygenase-4	Glycine max	239-251
9522277-0	1998	N-dealkylation of aminopyrine catalyzed by soybean lipoxygenase in the presence of hydrogen peroxide.	Nitrogen	0-1	linoleate 9S-lipoxygenase-4	Glycine max	51-63
9522277-0	1998	N-dealkylation of aminopyrine catalyzed by soybean lipoxygenase in the presence of hydrogen peroxide.	Aminopyrine	18-29	linoleate 9S-lipoxygenase-4	Glycine max	51-63
9522277-0	1998	N-dealkylation of aminopyrine catalyzed by soybean lipoxygenase in the presence of hydrogen peroxide.	Hydrogen Peroxide	83-100	linoleate 9S-lipoxygenase-4	Glycine max	51-63
9522277-1	1998	A hypothesis that lipoxygenase may mediate N-dealkylation of xenobiotics was investigated using the prototype drug aminopyrine and soybean lipoxygenase as a model enzyme in the presence of hydrogen peroxide.	Nitrogen	43-44	linoleate 9S-lipoxygenase-4	Glycine max	18-30
9522277-1	1998	A hypothesis that lipoxygenase may mediate N-dealkylation of xenobiotics was investigated using the prototype drug aminopyrine and soybean lipoxygenase as a model enzyme in the presence of hydrogen peroxide.	Aminopyrine	115-126	linoleate 9S-lipoxygenase-4	Glycine max	18-30
9522277-1	1998	A hypothesis that lipoxygenase may mediate N-dealkylation of xenobiotics was investigated using the prototype drug aminopyrine and soybean lipoxygenase as a model enzyme in the presence of hydrogen peroxide.	Hydrogen Peroxide	189-206	linoleate 9S-lipoxygenase-4	Glycine max	18-30
9522277-1	1998	A hypothesis that lipoxygenase may mediate N-dealkylation of xenobiotics was investigated using the prototype drug aminopyrine and soybean lipoxygenase as a model enzyme in the presence of hydrogen peroxide.	Hydrogen Peroxide	189-206	linoleate 9S-lipoxygenase-4	Glycine max	139-151
9522277-5	1998	The reaction was significantly inhibited by nordihydroguaiaretic acid and gossypol, the classical inhibitors of lipoxygenase.	Masoprocol	44-69	linoleate 9S-lipoxygenase-4	Glycine max	112-124
9522277-5	1998	The reaction was significantly inhibited by nordihydroguaiaretic acid and gossypol, the classical inhibitors of lipoxygenase.	Gossypol	74-82	linoleate 9S-lipoxygenase-4	Glycine max	112-124
9522277-10	1998	Collectively, the evidence presented suggests for the first time that lipoxygenase pathway may be involved in N-demethylation of aminopyrine and other chemicals.	Aminopyrine	129-140	linoleate 9S-lipoxygenase-4	Glycine max	70-82
9335571-5	1997	Results from stopped-flow studies indicate that the hydroperoxide level influences the rate of Compound II formation indirectly, via changes in the transient accumulation of Compound I, rather than by reducing Compound I. PGHS and soybean lipoxygenase reactions with 11,14-eicosadienoic acid (20:2) were also analyzed using a spectrophotometer cuvette fitted with an oxygen electrode to monitor lipid product formation and oxygen consumption simultaneously.	eicosa-11,14-dienoic acid	267-291	linoleate 9S-lipoxygenase-4	Glycine max	239-251
9335571-5	1997	Results from stopped-flow studies indicate that the hydroperoxide level influences the rate of Compound II formation indirectly, via changes in the transient accumulation of Compound I, rather than by reducing Compound I. PGHS and soybean lipoxygenase reactions with 11,14-eicosadienoic acid (20:2) were also analyzed using a spectrophotometer cuvette fitted with an oxygen electrode to monitor lipid product formation and oxygen consumption simultaneously.	Oxygen	367-373	linoleate 9S-lipoxygenase-4	Glycine max	239-251
9335571-6	1997	The results show that the oxygen electrode signal is inherently dampened and thus underestimates the oxygen consumption rate; the discrepancy is much larger for the more rapidly accelerating PGHS reaction than for the lipoxygenase reaction.	Oxygen	26-32	linoleate 9S-lipoxygenase-4	Glycine max	218-230
9335571-6	1997	The results show that the oxygen electrode signal is inherently dampened and thus underestimates the oxygen consumption rate; the discrepancy is much larger for the more rapidly accelerating PGHS reaction than for the lipoxygenase reaction.	Oxygen	101-107	linoleate 9S-lipoxygenase-4	Glycine max	218-230
9335571-7	1997	When correction is made for the electrode dampening, the ratio between the peak rates of oxygen consumption and lipid product formation was near unity for both PGHS and lipoxygenase, indicating a reaction stoichiometry of about 1 mol of O2 consumed/mol of 20:2 oxygenated for both enzymes.	Oxygen	89-95	linoleate 9S-lipoxygenase-4	Glycine max	160-181
9335571-7	1997	When correction is made for the electrode dampening, the ratio between the peak rates of oxygen consumption and lipid product formation was near unity for both PGHS and lipoxygenase, indicating a reaction stoichiometry of about 1 mol of O2 consumed/mol of 20:2 oxygenated for both enzymes.	Oxygen	237-239	linoleate 9S-lipoxygenase-4	Glycine max	160-181
9295158-0	1997	Kinetic characteristics of the enzymatic conversion in presence of cyclodextrins: study of the oxidation of polyunsaturated fatty acids by lipoxygenase.	Cyclodextrins	67-80	linoleate 9S-lipoxygenase-4	Glycine max	139-151
9295158-0	1997	Kinetic characteristics of the enzymatic conversion in presence of cyclodextrins: study of the oxidation of polyunsaturated fatty acids by lipoxygenase.	Fatty Acids, Unsaturated	108-135	linoleate 9S-lipoxygenase-4	Glycine max	139-151
9295158-2	1997	In order to evaluate the behaviour of the enzymes in presence of CDs a study of the lipoxygenase (LOX)-catalyzed oxidation of polyunsaturated fatty acids (PUFA) as model reaction has been carried out.	Cyclodextrins	65-68	linoleate 9S-lipoxygenase-4	Glycine max	84-96
9295158-2	1997	In order to evaluate the behaviour of the enzymes in presence of CDs a study of the lipoxygenase (LOX)-catalyzed oxidation of polyunsaturated fatty acids (PUFA) as model reaction has been carried out.	Cyclodextrins	65-68	linoleate 9S-lipoxygenase-4	Glycine max	98-101
9295158-2	1997	In order to evaluate the behaviour of the enzymes in presence of CDs a study of the lipoxygenase (LOX)-catalyzed oxidation of polyunsaturated fatty acids (PUFA) as model reaction has been carried out.	Fatty Acids, Unsaturated	126-153	linoleate 9S-lipoxygenase-4	Glycine max	84-96
9295158-2	1997	In order to evaluate the behaviour of the enzymes in presence of CDs a study of the lipoxygenase (LOX)-catalyzed oxidation of polyunsaturated fatty acids (PUFA) as model reaction has been carried out.	Fatty Acids, Unsaturated	126-153	linoleate 9S-lipoxygenase-4	Glycine max	98-101
9295158-2	1997	In order to evaluate the behaviour of the enzymes in presence of CDs a study of the lipoxygenase (LOX)-catalyzed oxidation of polyunsaturated fatty acids (PUFA) as model reaction has been carried out.	Fatty Acids, Unsaturated	155-159	linoleate 9S-lipoxygenase-4	Glycine max	84-96
9295158-2	1997	In order to evaluate the behaviour of the enzymes in presence of CDs a study of the lipoxygenase (LOX)-catalyzed oxidation of polyunsaturated fatty acids (PUFA) as model reaction has been carried out.	Fatty Acids, Unsaturated	155-159	linoleate 9S-lipoxygenase-4	Glycine max	98-101
9295158-9	1997	For the oxidation of PUFA by LOX in the presence of beta-CD we propose a model in which free PUFA is the only effective substrate, thus the oxidation of the complexed substrate requires the previous dissociation of the complex.	Fatty Acids, Unsaturated	21-25	linoleate 9S-lipoxygenase-4	Glycine max	29-32
9295158-9	1997	For the oxidation of PUFA by LOX in the presence of beta-CD we propose a model in which free PUFA is the only effective substrate, thus the oxidation of the complexed substrate requires the previous dissociation of the complex.	betadex	52-59	linoleate 9S-lipoxygenase-4	Glycine max	29-32
9295158-9	1997	For the oxidation of PUFA by LOX in the presence of beta-CD we propose a model in which free PUFA is the only effective substrate, thus the oxidation of the complexed substrate requires the previous dissociation of the complex.	Fatty Acids, Unsaturated	93-97	linoleate 9S-lipoxygenase-4	Glycine max	29-32
9295158-12	1997	CD was shown to slow down the reaction rate of LOX, specifically due to the increase of Km, Vmax remaining unchanged.	Cyclodextrins	0-2	linoleate 9S-lipoxygenase-4	Glycine max	47-50
9295158-16	1997	From the observation of the reaction progress curves in the conditions of the CD assay, we have studied some characteristic parameters of the oxidation of PUFA by LOX in this new medium, such as enzymatic activity, duration of linear product accumulation and the lag phase.	Cyclodextrins	78-80	linoleate 9S-lipoxygenase-4	Glycine max	163-166
9109655-12	1997	The 9- and 13-hydroperoxide products that are formed from 9-ODEYA and 12-ODEYA, respectively, oxidize Fe(II)-lipoxygenase to its Fe(III) state and are weak lipoxygenase inhibitors.	ferric sulfate	129-136	linoleate 9S-lipoxygenase-4	Glycine max	156-168
9109655-0	1997	Lipoxygenase is irreversibly inactivated by the hydroperoxides formed from the enynoic analogues of linoleic acid.	Hydrogen Peroxide	48-62	linoleate 9S-lipoxygenase-4	Glycine max	0-12
9109655-13	1997	11-HP-12-ODEYA is, however, the most powerful inhibitor and is able to oxidize Fe(II)-lipoxygenase to Fe(III)-lipoxygenase.	11-hp-12-odeya	0-14	linoleate 9S-lipoxygenase-4	Glycine max	86-98
9109655-0	1997	Lipoxygenase is irreversibly inactivated by the hydroperoxides formed from the enynoic analogues of linoleic acid.	Linoleic Acid	100-113	linoleate 9S-lipoxygenase-4	Glycine max	0-12
9109655-1	1997	Triple bond analogues of natural fatty acids irreversibly inactivate lipoxygenase during their enzymatic conversion [Nieuwenhuizen, W. F., et al.	Fatty Acids	33-44	linoleate 9S-lipoxygenase-4	Glycine max	69-81
9109655-13	1997	11-HP-12-ODEYA is, however, the most powerful inhibitor and is able to oxidize Fe(II)-lipoxygenase to Fe(III)-lipoxygenase.	11-hp-12-odeya	0-14	linoleate 9S-lipoxygenase-4	Glycine max	110-122
9109655-4	1997	During the inactivation process, Fe(III)-lipoxygenase converts 9-ODEYA into three products, i.e. 11-oxooctadec-9-en-12-ynoic acid, racemic 9-hydroxy-10(E)-octadec-10-en-12-ynoic acid, and racemic 9-hydroperoxy-10(E)-octadec-10-en-12-ynoic acid.	9-odeya	63-70	linoleate 9S-lipoxygenase-4	Glycine max	41-53
9109655-14	1997	11-HP-12-ODEYA is converted into 11-oxo-12-ODEYA by Fe(III)-lipoxygenase.	11-hp-12-odeya	0-14	linoleate 9S-lipoxygenase-4	Glycine max	60-72
9109655-4	1997	During the inactivation process, Fe(III)-lipoxygenase converts 9-ODEYA into three products, i.e. 11-oxooctadec-9-en-12-ynoic acid, racemic 9-hydroxy-10(E)-octadec-10-en-12-ynoic acid, and racemic 9-hydroperoxy-10(E)-octadec-10-en-12-ynoic acid.	11-oxooctadec-9-en-12-ynoic acid	97-129	linoleate 9S-lipoxygenase-4	Glycine max	41-53
9109655-14	1997	11-HP-12-ODEYA is converted into 11-oxo-12-ODEYA by Fe(III)-lipoxygenase.	11-oxo-12-odeya	33-48	linoleate 9S-lipoxygenase-4	Glycine max	60-72
9109655-4	1997	During the inactivation process, Fe(III)-lipoxygenase converts 9-ODEYA into three products, i.e. 11-oxooctadec-9-en-12-ynoic acid, racemic 9-hydroxy-10(E)-octadec-10-en-12-ynoic acid, and racemic 9-hydroperoxy-10(E)-octadec-10-en-12-ynoic acid.	9-hydroxy-10(e)-octadec-10-en-12-ynoic acid	139-182	linoleate 9S-lipoxygenase-4	Glycine max	41-53
9109655-4	1997	During the inactivation process, Fe(III)-lipoxygenase converts 9-ODEYA into three products, i.e. 11-oxooctadec-9-en-12-ynoic acid, racemic 9-hydroxy-10(E)-octadec-10-en-12-ynoic acid, and racemic 9-hydroperoxy-10(E)-octadec-10-en-12-ynoic acid.	9-hydroperoxy-10(e)-octadec-10-en-12-ynoic acid	196-243	linoleate 9S-lipoxygenase-4	Glycine max	41-53
9109655-12	1997	The 9- and 13-hydroperoxide products that are formed from 9-ODEYA and 12-ODEYA, respectively, oxidize Fe(II)-lipoxygenase to its Fe(III) state and are weak lipoxygenase inhibitors.	9- and 13-hydroperoxide	4-27	linoleate 9S-lipoxygenase-4	Glycine max	109-121
9109655-12	1997	The 9- and 13-hydroperoxide products that are formed from 9-ODEYA and 12-ODEYA, respectively, oxidize Fe(II)-lipoxygenase to its Fe(III) state and are weak lipoxygenase inhibitors.	9- and 13-hydroperoxide	4-27	linoleate 9S-lipoxygenase-4	Glycine max	156-168
9109655-12	1997	The 9- and 13-hydroperoxide products that are formed from 9-ODEYA and 12-ODEYA, respectively, oxidize Fe(II)-lipoxygenase to its Fe(III) state and are weak lipoxygenase inhibitors.	9-odeya	58-65	linoleate 9S-lipoxygenase-4	Glycine max	109-121
9109655-12	1997	The 9- and 13-hydroperoxide products that are formed from 9-ODEYA and 12-ODEYA, respectively, oxidize Fe(II)-lipoxygenase to its Fe(III) state and are weak lipoxygenase inhibitors.	9-odeya	58-65	linoleate 9S-lipoxygenase-4	Glycine max	156-168
9109655-12	1997	The 9- and 13-hydroperoxide products that are formed from 9-ODEYA and 12-ODEYA, respectively, oxidize Fe(II)-lipoxygenase to its Fe(III) state and are weak lipoxygenase inhibitors.	12-odeya	70-78	linoleate 9S-lipoxygenase-4	Glycine max	109-121
9109655-15	1997	We propose a mechanism for the latter reaction in which Fe(III)-lipoxygenase abstracts the bisallylic hydrogen H-11 from 11-HP-12-ODEYA, yielding a hydroperoxyl radical which is subsequently cleaved into 11-oxo-ODEYA and a hydroxyl radical which may inactivate the enzyme.	hydrogen h-11	102-115	linoleate 9S-lipoxygenase-4	Glycine max	64-76
9109655-12	1997	The 9- and 13-hydroperoxide products that are formed from 9-ODEYA and 12-ODEYA, respectively, oxidize Fe(II)-lipoxygenase to its Fe(III) state and are weak lipoxygenase inhibitors.	12-odeya	70-78	linoleate 9S-lipoxygenase-4	Glycine max	156-168
9109655-12	1997	The 9- and 13-hydroperoxide products that are formed from 9-ODEYA and 12-ODEYA, respectively, oxidize Fe(II)-lipoxygenase to its Fe(III) state and are weak lipoxygenase inhibitors.	ferric sulfate	129-136	linoleate 9S-lipoxygenase-4	Glycine max	109-121
9109655-15	1997	We propose a mechanism for the latter reaction in which Fe(III)-lipoxygenase abstracts the bisallylic hydrogen H-11 from 11-HP-12-ODEYA, yielding a hydroperoxyl radical which is subsequently cleaved into 11-oxo-ODEYA and a hydroxyl radical which may inactivate the enzyme.	11-hp-12-odeya	121-135	linoleate 9S-lipoxygenase-4	Glycine max	64-76
9109655-15	1997	We propose a mechanism for the latter reaction in which Fe(III)-lipoxygenase abstracts the bisallylic hydrogen H-11 from 11-HP-12-ODEYA, yielding a hydroperoxyl radical which is subsequently cleaved into 11-oxo-ODEYA and a hydroxyl radical which may inactivate the enzyme.	Hydroperoxy radical	148-168	linoleate 9S-lipoxygenase-4	Glycine max	64-76
9109655-15	1997	We propose a mechanism for the latter reaction in which Fe(III)-lipoxygenase abstracts the bisallylic hydrogen H-11 from 11-HP-12-ODEYA, yielding a hydroperoxyl radical which is subsequently cleaved into 11-oxo-ODEYA and a hydroxyl radical which may inactivate the enzyme.	11-oxo-odeya	204-216	linoleate 9S-lipoxygenase-4	Glycine max	64-76
9109655-15	1997	We propose a mechanism for the latter reaction in which Fe(III)-lipoxygenase abstracts the bisallylic hydrogen H-11 from 11-HP-12-ODEYA, yielding a hydroperoxyl radical which is subsequently cleaved into 11-oxo-ODEYA and a hydroxyl radical which may inactivate the enzyme.	Hydroxyl Radical	223-239	linoleate 9S-lipoxygenase-4	Glycine max	64-76
8679548-1	1996	We have used stopped-flow rapid reaction methods, employing both fluorescence and absorbance monitoring, together with HPLC analysis of the products to study the activation of soybean 15-lipoxygenase by 13(S)-hydroperoxy-9, 11(E,Z)-octadecadienoic acid (13-HPOD).	13-Hpode	254-261	linoleate 9S-lipoxygenase-4	Glycine max	187-199
9029051-1	1997	]4-aminobiphenyl (4-ABP) co-oxidation catalyzed by the human term placental lipoxygenase (HTPLO), purified by affinity chromatography, was studied in the presence of linoleic acid (LA).	Linoleic Acid	166-179	linoleate 9S-lipoxygenase-4	Glycine max	76-88
9005450-0	1996	Benzophenanthridine alkaloids of Chelidonium majus; I. Inhibition of 5- and 12-lipoxygenase by a non-redox mechanism.	benzophenanthridine alkaloids	0-29	linoleate 9S-lipoxygenase-4	Glycine max	79-91
9005450-1	1996	The benzophenanthridine alkaloids sanguinarine and chelerythrine of Chelidonium majus, L. (Papaveraceae), are potent inhibitors of 5-lipoxygenase in polymorphonuclear leukocytes and 12-lipoxygenase in mouse epidermis, while the activity of soybean lipoxygenase is not influenced.	Benzophenanthridines	4-23	linoleate 9S-lipoxygenase-4	Glycine max	133-145
9005450-1	1996	The benzophenanthridine alkaloids sanguinarine and chelerythrine of Chelidonium majus, L. (Papaveraceae), are potent inhibitors of 5-lipoxygenase in polymorphonuclear leukocytes and 12-lipoxygenase in mouse epidermis, while the activity of soybean lipoxygenase is not influenced.	Benzophenanthridines	4-23	linoleate 9S-lipoxygenase-4	Glycine max	185-197
9005450-1	1996	The benzophenanthridine alkaloids sanguinarine and chelerythrine of Chelidonium majus, L. (Papaveraceae), are potent inhibitors of 5-lipoxygenase in polymorphonuclear leukocytes and 12-lipoxygenase in mouse epidermis, while the activity of soybean lipoxygenase is not influenced.	Alkaloids	24-33	linoleate 9S-lipoxygenase-4	Glycine max	133-145
9005450-1	1996	The benzophenanthridine alkaloids sanguinarine and chelerythrine of Chelidonium majus, L. (Papaveraceae), are potent inhibitors of 5-lipoxygenase in polymorphonuclear leukocytes and 12-lipoxygenase in mouse epidermis, while the activity of soybean lipoxygenase is not influenced.	Alkaloids	24-33	linoleate 9S-lipoxygenase-4	Glycine max	185-197
9005450-1	1996	The benzophenanthridine alkaloids sanguinarine and chelerythrine of Chelidonium majus, L. (Papaveraceae), are potent inhibitors of 5-lipoxygenase in polymorphonuclear leukocytes and 12-lipoxygenase in mouse epidermis, while the activity of soybean lipoxygenase is not influenced.	sanguinarine	34-46	linoleate 9S-lipoxygenase-4	Glycine max	133-145
9005450-1	1996	The benzophenanthridine alkaloids sanguinarine and chelerythrine of Chelidonium majus, L. (Papaveraceae), are potent inhibitors of 5-lipoxygenase in polymorphonuclear leukocytes and 12-lipoxygenase in mouse epidermis, while the activity of soybean lipoxygenase is not influenced.	sanguinarine	34-46	linoleate 9S-lipoxygenase-4	Glycine max	185-197
9005450-1	1996	The benzophenanthridine alkaloids sanguinarine and chelerythrine of Chelidonium majus, L. (Papaveraceae), are potent inhibitors of 5-lipoxygenase in polymorphonuclear leukocytes and 12-lipoxygenase in mouse epidermis, while the activity of soybean lipoxygenase is not influenced.	chelerythrine	51-64	linoleate 9S-lipoxygenase-4	Glycine max	133-145
8679612-0	1996	Selenite incubated with NADPH and mammalian thioredoxin reductase yields selenide, which inhibits lipoxygenase and changes the electron spin resonance spectrum of the active site iron.	NADP	24-29	linoleate 9S-lipoxygenase-4	Glycine max	98-110
8679612-0	1996	Selenite incubated with NADPH and mammalian thioredoxin reductase yields selenide, which inhibits lipoxygenase and changes the electron spin resonance spectrum of the active site iron.	Selenium	73-81	linoleate 9S-lipoxygenase-4	Glycine max	98-110
8679612-10	1996	Since selenide is known to be efficiently oxidized by oxygen and to form elemental selenium the results evidence that selenide was the inhibitor of lipoxygenase activity in the anaerobic preincubations.	Selenium	6-14	linoleate 9S-lipoxygenase-4	Glycine max	148-160
8679612-10	1996	Since selenide is known to be efficiently oxidized by oxygen and to form elemental selenium the results evidence that selenide was the inhibitor of lipoxygenase activity in the anaerobic preincubations.	Selenium	83-91	linoleate 9S-lipoxygenase-4	Glycine max	148-160
8679612-10	1996	Since selenide is known to be efficiently oxidized by oxygen and to form elemental selenium the results evidence that selenide was the inhibitor of lipoxygenase activity in the anaerobic preincubations.	Selenium	118-126	linoleate 9S-lipoxygenase-4	Glycine max	148-160
8679548-0	1996	Role of lipid hydroperoxides in the activation of 15-lipoxygenase.	Lipid Peroxides	8-28	linoleate 9S-lipoxygenase-4	Glycine max	53-65
8679548-1	1996	We have used stopped-flow rapid reaction methods, employing both fluorescence and absorbance monitoring, together with HPLC analysis of the products to study the activation of soybean 15-lipoxygenase by 13(S)-hydroperoxy-9, 11(E,Z)-octadecadienoic acid (13-HPOD).	13(s)-hydroperoxy-9, 11(e,z)-octadecadienoic acid	203-252	linoleate 9S-lipoxygenase-4	Glycine max	187-199
9134748-0	1997	Modulation of lipoxygenase activity by bacterial hopanoids.	hopanoids	49-58	linoleate 9S-lipoxygenase-4	Glycine max	14-26
9134748-1	1997	Tetrahydroxybacteriohopane (1), a bacterial hopanoid, inhibited soybean 15-lipoxygenase with an IC50 of about 10 microM.	32,33,34,35-bacteriohopanetetrol	0-26	linoleate 9S-lipoxygenase-4	Glycine max	75-87
9134748-1	1997	Tetrahydroxybacteriohopane (1), a bacterial hopanoid, inhibited soybean 15-lipoxygenase with an IC50 of about 10 microM.	hopanoid	44-52	linoleate 9S-lipoxygenase-4	Glycine max	75-87
9134748-3	1997	Two other bacterial hopanoids, tetrahydroxybacteriohopane glucosamine (2) and tetrahydroxybacteriohopane ether (3), stimulated the activity of soybean 15-lipoxygenase.	hopanoids	20-29	linoleate 9S-lipoxygenase-4	Glycine max	154-166
9134748-3	1997	Two other bacterial hopanoids, tetrahydroxybacteriohopane glucosamine (2) and tetrahydroxybacteriohopane ether (3), stimulated the activity of soybean 15-lipoxygenase.	tetrahydroxybacteriohopane glucosamine	31-69	linoleate 9S-lipoxygenase-4	Glycine max	154-166
9134748-3	1997	Two other bacterial hopanoids, tetrahydroxybacteriohopane glucosamine (2) and tetrahydroxybacteriohopane ether (3), stimulated the activity of soybean 15-lipoxygenase.	tetrahydroxybacteriohopane ether	78-110	linoleate 9S-lipoxygenase-4	Glycine max	154-166
9005450-1	1996	The benzophenanthridine alkaloids sanguinarine and chelerythrine of Chelidonium majus, L. (Papaveraceae), are potent inhibitors of 5-lipoxygenase in polymorphonuclear leukocytes and 12-lipoxygenase in mouse epidermis, while the activity of soybean lipoxygenase is not influenced.	chelerythrine	51-64	linoleate 9S-lipoxygenase-4	Glycine max	185-197
8888310-1	1996	5-S-cysteinyl-dopa (cysdopa) and 5-S-cysteinyl-dopamine (cysdopamine) are oxidized in vitro by soybean lipoxygenase (LOX) in the presence of hydrogen peroxide giving rise to the corresponding pheomelanins.	Cysteinyldopa	20-27	linoleate 9S-lipoxygenase-4	Glycine max	117-120
8681970-0	1996	The effect of linoleic acid on pH inside sodium bis(2-ethylhexyl)sulfosuccinate reverse micelles in isooctane and on the enzymic activity of soybean lipoxygenase.	Linoleic Acid	14-27	linoleate 9S-lipoxygenase-4	Glycine max	149-161
8681970-14	1996	The latter conclusion is consistent with the data on lipoxygenase activity towards linoleyl sulfate in aqueous solutions [Bild, G. S., Ramadoss, C. S. & Axelrod, B.	linoleyl sulfate	83-99	linoleate 9S-lipoxygenase-4	Glycine max	53-65
8681970-14	1996	The latter conclusion is consistent with the data on lipoxygenase activity towards linoleyl sulfate in aqueous solutions [Bild, G. S., Ramadoss, C. S. & Axelrod, B.	Adenosine Monophosphate	152-155	linoleate 9S-lipoxygenase-4	Glycine max	53-65
8690317-0	1996	Oxidation of ascorbic acid by lipoxygenase: effect of selected chemicals.	Ascorbic Acid	13-26	linoleate 9S-lipoxygenase-4	Glycine max	30-42
8690317-1	1996	The ability of soybean lipoxygenase to mediate ascorbic acid oxidation was examined.	Ascorbic Acid	47-60	linoleate 9S-lipoxygenase-4	Glycine max	23-35
8690317-3	1996	The optimal conditions to observe maximal enzyme velocity included the presence of 800 microM linoleic acid, 500 microM ascorbic acid and 25 nM soybean lipoxygenase in 50 mM Tris buffer, pH 8.3.	Tromethamine	174-178	linoleate 9S-lipoxygenase-4	Glycine max	152-164
8690317-5	1996	The effect of ascorbic acid on the lipoxygenase-catalysed co-oxidation of xenobiotics was also evaluated.	Ascorbic Acid	14-27	linoleate 9S-lipoxygenase-4	Glycine max	35-47
8690317-6	1996	Ascorbic acid markedly decreased the rate of oxidation of test xenobiotics by the lipoxygenase.	Ascorbic Acid	0-13	linoleate 9S-lipoxygenase-4	Glycine max	82-94
8690317-7	1996	In contrast, the rate of ascorbic acid co-oxidation was enhanced significantly by the presence of xenobiotics, which are co-oxidized simultaneously by lipoxygenase through the formation of free radicals.	Ascorbic Acid	25-38	linoleate 9S-lipoxygenase-4	Glycine max	151-163
8690317-7	1996	In contrast, the rate of ascorbic acid co-oxidation was enhanced significantly by the presence of xenobiotics, which are co-oxidized simultaneously by lipoxygenase through the formation of free radicals.	Free Radicals	189-202	linoleate 9S-lipoxygenase-4	Glycine max	151-163
8888310-0	1996	Pheomelanin production by the lipoxygenase-catalyzed oxidation of 5-S-cysteinyldopa and 5-S-cysteinyldopamine.	pheomelanin	0-11	linoleate 9S-lipoxygenase-4	Glycine max	30-42
8888310-0	1996	Pheomelanin production by the lipoxygenase-catalyzed oxidation of 5-S-cysteinyldopa and 5-S-cysteinyldopamine.	Cysteinyldopa	66-83	linoleate 9S-lipoxygenase-4	Glycine max	30-42
8888310-1	1996	5-S-cysteinyl-dopa (cysdopa) and 5-S-cysteinyl-dopamine (cysdopamine) are oxidized in vitro by soybean lipoxygenase (LOX) in the presence of hydrogen peroxide giving rise to the corresponding pheomelanins.	5-S-cysteinyldopamine	33-55	linoleate 9S-lipoxygenase-4	Glycine max	103-115
8888310-0	1996	Pheomelanin production by the lipoxygenase-catalyzed oxidation of 5-S-cysteinyldopa and 5-S-cysteinyldopamine.	5-S-cysteinyldopamine	88-109	linoleate 9S-lipoxygenase-4	Glycine max	30-42
8888310-1	1996	5-S-cysteinyl-dopa (cysdopa) and 5-S-cysteinyl-dopamine (cysdopamine) are oxidized in vitro by soybean lipoxygenase (LOX) in the presence of hydrogen peroxide giving rise to the corresponding pheomelanins.	5-S-cysteinyldopamine	33-55	linoleate 9S-lipoxygenase-4	Glycine max	117-120
8888310-1	1996	5-S-cysteinyl-dopa (cysdopa) and 5-S-cysteinyl-dopamine (cysdopamine) are oxidized in vitro by soybean lipoxygenase (LOX) in the presence of hydrogen peroxide giving rise to the corresponding pheomelanins.	Cysteinyldopa	0-18	linoleate 9S-lipoxygenase-4	Glycine max	103-115
8888310-1	1996	5-S-cysteinyl-dopa (cysdopa) and 5-S-cysteinyl-dopamine (cysdopamine) are oxidized in vitro by soybean lipoxygenase (LOX) in the presence of hydrogen peroxide giving rise to the corresponding pheomelanins.	Cysteinyldopa	0-18	linoleate 9S-lipoxygenase-4	Glycine max	117-120
8888310-1	1996	5-S-cysteinyl-dopa (cysdopa) and 5-S-cysteinyl-dopamine (cysdopamine) are oxidized in vitro by soybean lipoxygenase (LOX) in the presence of hydrogen peroxide giving rise to the corresponding pheomelanins.	cysdopamine	57-68	linoleate 9S-lipoxygenase-4	Glycine max	103-115
8888310-1	1996	5-S-cysteinyl-dopa (cysdopa) and 5-S-cysteinyl-dopamine (cysdopamine) are oxidized in vitro by soybean lipoxygenase (LOX) in the presence of hydrogen peroxide giving rise to the corresponding pheomelanins.	Cysteinyldopa	20-27	linoleate 9S-lipoxygenase-4	Glycine max	103-115
8888310-1	1996	5-S-cysteinyl-dopa (cysdopa) and 5-S-cysteinyl-dopamine (cysdopamine) are oxidized in vitro by soybean lipoxygenase (LOX) in the presence of hydrogen peroxide giving rise to the corresponding pheomelanins.	cysdopamine	57-68	linoleate 9S-lipoxygenase-4	Glycine max	117-120
8888310-1	1996	5-S-cysteinyl-dopa (cysdopa) and 5-S-cysteinyl-dopamine (cysdopamine) are oxidized in vitro by soybean lipoxygenase (LOX) in the presence of hydrogen peroxide giving rise to the corresponding pheomelanins.	Hydrogen Peroxide	141-158	linoleate 9S-lipoxygenase-4	Glycine max	103-115
8888310-1	1996	5-S-cysteinyl-dopa (cysdopa) and 5-S-cysteinyl-dopamine (cysdopamine) are oxidized in vitro by soybean lipoxygenase (LOX) in the presence of hydrogen peroxide giving rise to the corresponding pheomelanins.	Hydrogen Peroxide	141-158	linoleate 9S-lipoxygenase-4	Glycine max	117-120
8888310-1	1996	5-S-cysteinyl-dopa (cysdopa) and 5-S-cysteinyl-dopamine (cysdopamine) are oxidized in vitro by soybean lipoxygenase (LOX) in the presence of hydrogen peroxide giving rise to the corresponding pheomelanins.	pheomelanin	192-204	linoleate 9S-lipoxygenase-4	Glycine max	103-115
8888310-1	1996	5-S-cysteinyl-dopa (cysdopa) and 5-S-cysteinyl-dopamine (cysdopamine) are oxidized in vitro by soybean lipoxygenase (LOX) in the presence of hydrogen peroxide giving rise to the corresponding pheomelanins.	pheomelanin	192-204	linoleate 9S-lipoxygenase-4	Glycine max	117-120
8639489-0	1996	Mechanism of lipoxygenase inactivation by the linoleic acid analogue octadeca-9,12-diynoic acid.	Linoleic Acid	46-59	linoleate 9S-lipoxygenase-4	Glycine max	13-25
8660537-5	1996	The utility of low-collision-energy ESI-MS/MS to examine biological samples was shown by examining the products formed by the metabolism of linoleic (18:2omega6) and arachidonic (20:4omega6) acids by soybean lipoxygenase using aerobic and anaerobic incubation conditions that generated increasingly complex mixes of metabolites.	Linoleic Acid	140-148	linoleate 9S-lipoxygenase-4	Glycine max	208-220
8660537-5	1996	The utility of low-collision-energy ESI-MS/MS to examine biological samples was shown by examining the products formed by the metabolism of linoleic (18:2omega6) and arachidonic (20:4omega6) acids by soybean lipoxygenase using aerobic and anaerobic incubation conditions that generated increasingly complex mixes of metabolites.	arachidonic	166-177	linoleate 9S-lipoxygenase-4	Glycine max	208-220
8639489-0	1996	Mechanism of lipoxygenase inactivation by the linoleic acid analogue octadeca-9,12-diynoic acid.	octadeca-9,12-diynoic acid	69-95	linoleate 9S-lipoxygenase-4	Glycine max	13-25
8639489-1	1996	During the irreversible inactivation of soybean Fe(III)-lipoxygenase [Fe(III)-LOX] by octadeca-9,12-diynoic acid (ODYA), significant quantities of 11-oxooctadeca-9,12 diynoic acid (11-oxo-ODYA) are formed [Nieuwenhuizen, W. F., et al.	octadeca-9,12-diynoic acid	86-112	linoleate 9S-lipoxygenase-4	Glycine max	56-68
8639489-1	1996	During the irreversible inactivation of soybean Fe(III)-lipoxygenase [Fe(III)-LOX] by octadeca-9,12-diynoic acid (ODYA), significant quantities of 11-oxooctadeca-9,12 diynoic acid (11-oxo-ODYA) are formed [Nieuwenhuizen, W. F., et al.	11-oxooctadeca-9,12-diynoic acid	147-179	linoleate 9S-lipoxygenase-4	Glycine max	56-68
7585636-9	1995	In the absence of NADPH, NNK metabolism resulted in the formation of keto acid, keto aldehyde, and keto alcohol, and the activities in different lung samples were decreased by indomethacin (100 microM; cyclooxygenase inhibitor) or nordihydroguaiaretic acid (100 microM; lipoxygenase inhibitor) by 0-27% or 30-66%, respectively.	Indomethacin	176-188	linoleate 9S-lipoxygenase-4	Glycine max	270-282
8904293-3	1996	In the present study we have used soybean lipoxygenase to model the interaction of the enzyme with LDL and show that a direct oxygenation of fatty acids occurs, including those esterified to cholesterol, with no lag phase or change in electrophoretic mobility of the LDL particle but with some depletion of alpha-tocopherol.	Fatty Acids	141-152	linoleate 9S-lipoxygenase-4	Glycine max	42-54
8904293-5	1996	When lipoxygenase-treated LDL is exposed to either copper (II) or metMb, a rapid oxidation process occurs, resulting in a marked decrease in resistance to oxidation and an increase in the rate of modification to a form with increased electrophoretic mobility.	cupric ion	51-62	linoleate 9S-lipoxygenase-4	Glycine max	5-17
8904293-5	1996	When lipoxygenase-treated LDL is exposed to either copper (II) or metMb, a rapid oxidation process occurs, resulting in a marked decrease in resistance to oxidation and an increase in the rate of modification to a form with increased electrophoretic mobility.	metmb	66-71	linoleate 9S-lipoxygenase-4	Glycine max	5-17
8904293-7	1996	We propose that a synergistic interaction may occur between the peroxides inserted into LDL as a consequence of the enzymatic action of lipoxygenase with haem proteins or copper, which decreases the potency of the endogenous antioxidants and enhances oxidation.	Peroxides	64-73	linoleate 9S-lipoxygenase-4	Glycine max	136-148
8904293-7	1996	We propose that a synergistic interaction may occur between the peroxides inserted into LDL as a consequence of the enzymatic action of lipoxygenase with haem proteins or copper, which decreases the potency of the endogenous antioxidants and enhances oxidation.	Copper	171-177	linoleate 9S-lipoxygenase-4	Glycine max	136-148
8769897-2	1996	Linoleic acid (LA) and its hydroperoxide 13-L-hydroperoxylinoleic acid (LOOH) prepared with soybean lipoxygenase inhibited the response of GABARs in the presence of GABA at high concentrations.	Linoleic Acid	0-13	linoleate 9S-lipoxygenase-4	Glycine max	100-112
8769897-2	1996	Linoleic acid (LA) and its hydroperoxide 13-L-hydroperoxylinoleic acid (LOOH) prepared with soybean lipoxygenase inhibited the response of GABARs in the presence of GABA at high concentrations.	Hydrogen Peroxide	27-40	linoleate 9S-lipoxygenase-4	Glycine max	100-112
8769897-2	1996	Linoleic acid (LA) and its hydroperoxide 13-L-hydroperoxylinoleic acid (LOOH) prepared with soybean lipoxygenase inhibited the response of GABARs in the presence of GABA at high concentrations.	13(S)-HPODE	41-70	linoleate 9S-lipoxygenase-4	Glycine max	100-112
8769897-2	1996	Linoleic acid (LA) and its hydroperoxide 13-L-hydroperoxylinoleic acid (LOOH) prepared with soybean lipoxygenase inhibited the response of GABARs in the presence of GABA at high concentrations.	Lipid Peroxides	72-76	linoleate 9S-lipoxygenase-4	Glycine max	100-112
8769897-2	1996	Linoleic acid (LA) and its hydroperoxide 13-L-hydroperoxylinoleic acid (LOOH) prepared with soybean lipoxygenase inhibited the response of GABARs in the presence of GABA at high concentrations.	gabars	139-145	linoleate 9S-lipoxygenase-4	Glycine max	100-112
8769897-2	1996	Linoleic acid (LA) and its hydroperoxide 13-L-hydroperoxylinoleic acid (LOOH) prepared with soybean lipoxygenase inhibited the response of GABARs in the presence of GABA at high concentrations.	gamma-Aminobutyric Acid	139-143	linoleate 9S-lipoxygenase-4	Glycine max	100-112
7585636-11	1995	Soybean lipoxygenase increased the rate of formation of keto aldehyde and keto alcohol in a concentration-dependent manner.	keto aldehyde	56-69	linoleate 9S-lipoxygenase-4	Glycine max	8-20
7585636-11	1995	Soybean lipoxygenase increased the rate of formation of keto aldehyde and keto alcohol in a concentration-dependent manner.	keto alcohol	74-86	linoleate 9S-lipoxygenase-4	Glycine max	8-20
7585636-12	1995	The increased rate in NNK oxidation by arachidonic acid or lipoxygenase was inhibited completely by nordihydroguaiaretic acid.	Masoprocol	100-125	linoleate 9S-lipoxygenase-4	Glycine max	59-71
12228538-4	1995	Activity with 13S-HPOT increased 24-fold under anaerobic conditions reminiscent of a similar anaerobic promoted reaction of 13S-HPOD catalyzed by lipoxygenase (LOX) in the presence of linoleic acid.	5-chloro-3-tert-butyl-2'-chloro-4'-nitrosalicylanilide	14-17	linoleate 9S-lipoxygenase-4	Glycine max	146-158
8720128-4	1995	In addition, GL, glycyrrhetinic acid (GA) and soyasaponin beta g slightly inhibited LOX activity of the purified gp96 fraction, whereas oGA (a GA derivative) greatly inhibited its activity.	Glycyrrhizic Acid	13-15	linoleate 9S-lipoxygenase-4	Glycine max	84-87
8720128-4	1995	In addition, GL, glycyrrhetinic acid (GA) and soyasaponin beta g slightly inhibited LOX activity of the purified gp96 fraction, whereas oGA (a GA derivative) greatly inhibited its activity.	Glycyrrhetinic Acid	17-36	linoleate 9S-lipoxygenase-4	Glycine max	84-87
8720128-4	1995	In addition, GL, glycyrrhetinic acid (GA) and soyasaponin beta g slightly inhibited LOX activity of the purified gp96 fraction, whereas oGA (a GA derivative) greatly inhibited its activity.	Glycyrrhetinic Acid	38-40	linoleate 9S-lipoxygenase-4	Glycine max	84-87
8720128-6	1995	All these results taken together suggest that (i) gp96 purified from soybeans as a GL-binding protein belongs to the LOX family; and (ii) triterpenoid saponins, including GL, are involved in the regulation of the activities of CK-II and LOXs in plants, such as soybeans and roots of liquorice, which contain large quantities of saponins.	Saponins	151-159	linoleate 9S-lipoxygenase-4	Glycine max	117-120
8720128-6	1995	All these results taken together suggest that (i) gp96 purified from soybeans as a GL-binding protein belongs to the LOX family; and (ii) triterpenoid saponins, including GL, are involved in the regulation of the activities of CK-II and LOXs in plants, such as soybeans and roots of liquorice, which contain large quantities of saponins.	Glycyrrhizic Acid	83-85	linoleate 9S-lipoxygenase-4	Glycine max	117-120
8720128-6	1995	All these results taken together suggest that (i) gp96 purified from soybeans as a GL-binding protein belongs to the LOX family; and (ii) triterpenoid saponins, including GL, are involved in the regulation of the activities of CK-II and LOXs in plants, such as soybeans and roots of liquorice, which contain large quantities of saponins.	Saponins	328-336	linoleate 9S-lipoxygenase-4	Glycine max	117-120
8821124-0	1995	Oxygenation reactions of prostaglandins endoperoxide synthase and soybean lipoxygenase.	Prostaglandins	25-39	linoleate 9S-lipoxygenase-4	Glycine max	74-86
8821124-2	1995	The stoichiometry of the oxygenation reaction of cis,cis-eicosa-11,14-dienoic acid catalyzed by prostaglandin endoperoxide synthase and soybean lipoxygenase has been investigated by using steady-state initial rate measurements.	cis,cis-eicosa-11,14-dienoic acid	49-82	linoleate 9S-lipoxygenase-4	Glycine max	144-156
8821124-4	1995	The ratio of the two rates, d[conjugated diene/-d[O2], is 2/1 for the prostaglandin endoperoxide synthase catalyzed reaction and 1/1 for the lipoxygenase reaction.	diene	41-46	linoleate 9S-lipoxygenase-4	Glycine max	141-153
8821124-4	1995	The ratio of the two rates, d[conjugated diene/-d[O2], is 2/1 for the prostaglandin endoperoxide synthase catalyzed reaction and 1/1 for the lipoxygenase reaction.	Oxygen	50-52	linoleate 9S-lipoxygenase-4	Glycine max	141-153
8821124-4	1995	The ratio of the two rates, d[conjugated diene/-d[O2], is 2/1 for the prostaglandin endoperoxide synthase catalyzed reaction and 1/1 for the lipoxygenase reaction.	Prostaglandins	70-83	linoleate 9S-lipoxygenase-4	Glycine max	141-153
8585333-1	1995	Fourier transform infrared spectroscopy (FT-IR) studies of lipoxygenase at pressures of up to 1.2 GPa have shown changes in the amide I" band which correlate to structural changes of the enzyme.	Amides	128-133	linoleate 9S-lipoxygenase-4	Glycine max	59-71
7635257-6	1995	These flavonoids produced an inhibition of soybean lipoxygenase activity in a dose-dependent manner, with IC50 values (20 and 29 microM respectively) similar to the reference drug.	Flavonoids	6-16	linoleate 9S-lipoxygenase-4	Glycine max	51-63
12228538-4	1995	Activity with 13S-HPOT increased 24-fold under anaerobic conditions reminiscent of a similar anaerobic promoted reaction of 13S-HPOD catalyzed by lipoxygenase (LOX) in the presence of linoleic acid.	5-chloro-3-tert-butyl-2'-chloro-4'-nitrosalicylanilide	14-17	linoleate 9S-lipoxygenase-4	Glycine max	160-163
12228538-4	1995	Activity with 13S-HPOT increased 24-fold under anaerobic conditions reminiscent of a similar anaerobic promoted reaction of 13S-HPOD catalyzed by lipoxygenase (LOX) in the presence of linoleic acid.	5-chloro-3-tert-butyl-2'-chloro-4'-nitrosalicylanilide	124-127	linoleate 9S-lipoxygenase-4	Glycine max	146-158
12228538-4	1995	Activity with 13S-HPOT increased 24-fold under anaerobic conditions reminiscent of a similar anaerobic promoted reaction of 13S-HPOD catalyzed by lipoxygenase (LOX) in the presence of linoleic acid.	5-chloro-3-tert-butyl-2'-chloro-4'-nitrosalicylanilide	124-127	linoleate 9S-lipoxygenase-4	Glycine max	160-163
12228538-4	1995	Activity with 13S-HPOT increased 24-fold under anaerobic conditions reminiscent of a similar anaerobic promoted reaction of 13S-HPOD catalyzed by lipoxygenase (LOX) in the presence of linoleic acid.	Linoleic Acid	184-197	linoleate 9S-lipoxygenase-4	Glycine max	146-158
12228538-4	1995	Activity with 13S-HPOT increased 24-fold under anaerobic conditions reminiscent of a similar anaerobic promoted reaction of 13S-HPOD catalyzed by lipoxygenase (LOX) in the presence of linoleic acid.	Linoleic Acid	184-197	linoleate 9S-lipoxygenase-4	Glycine max	160-163
7878664-0	1995	Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice.	Phenytoin	53-62	linoleate 9S-lipoxygenase-4	Glycine max	13-25
7790873-4	1995	The relative amount of polyunsaturated fatty acids (as determined with soybean lipoxygenase) was increased in whole brains and crude synaptosomal membranes of the type II diabetic mice.	Fatty Acids, Unsaturated	23-50	linoleate 9S-lipoxygenase-4	Glycine max	79-91
7562953-0	1995	Lipoxygenase-mediated glutathione oxidation and superoxide generation.	Glutathione	22-33	linoleate 9S-lipoxygenase-4	Glycine max	0-12
7562953-1	1995	Soybean lipoxygenase-mediated cooxidation of reduced glutathione (GSH) and concomitant superoxide generation was examined.	Glutathione	53-64	linoleate 9S-lipoxygenase-4	Glycine max	8-20
7562953-1	1995	Soybean lipoxygenase-mediated cooxidation of reduced glutathione (GSH) and concomitant superoxide generation was examined.	Glutathione	66-69	linoleate 9S-lipoxygenase-4	Glycine max	8-20
7562953-1	1995	Soybean lipoxygenase-mediated cooxidation of reduced glutathione (GSH) and concomitant superoxide generation was examined.	Superoxides	87-97	linoleate 9S-lipoxygenase-4	Glycine max	8-20
7562953-6	1995	Besides LA, arachidonic and gamma-linolenic acids also supported the lipoxygenase-mediated GSH oxidation.	arachidonic	12-23	linoleate 9S-lipoxygenase-4	Glycine max	69-81
7562953-6	1995	Besides LA, arachidonic and gamma-linolenic acids also supported the lipoxygenase-mediated GSH oxidation.	gamma-Linolenic Acid	28-49	linoleate 9S-lipoxygenase-4	Glycine max	69-81
7562953-6	1995	Besides LA, arachidonic and gamma-linolenic acids also supported the lipoxygenase-mediated GSH oxidation.	Glutathione	91-94	linoleate 9S-lipoxygenase-4	Glycine max	69-81
7562953-11	1995	These results clearly suggest that lipoxygenase is capable of oxidizing GSH to GSSG and simultaneously generating superoxide anion radicals, which may contribute to oxidative stress in cells under certain conditions.	Glutathione	72-75	linoleate 9S-lipoxygenase-4	Glycine max	35-47
7562953-11	1995	These results clearly suggest that lipoxygenase is capable of oxidizing GSH to GSSG and simultaneously generating superoxide anion radicals, which may contribute to oxidative stress in cells under certain conditions.	Glutathione Disulfide	79-83	linoleate 9S-lipoxygenase-4	Glycine max	35-47
7562953-11	1995	These results clearly suggest that lipoxygenase is capable of oxidizing GSH to GSSG and simultaneously generating superoxide anion radicals, which may contribute to oxidative stress in cells under certain conditions.	Superoxides	114-139	linoleate 9S-lipoxygenase-4	Glycine max	35-47
7742320-1	1995	Treatment of soybean lipoxygenase isozyme 1 with its substrates, linoleic acid and oxygen, or product, 13(S)-hydroperoxy-9,11(Z,E)-octadecadienoic acid (13-HPOD), leads to the appearance of a purple color.	Linoleic Acid	65-78	linoleate 9S-lipoxygenase-4	Glycine max	21-33
7742320-1	1995	Treatment of soybean lipoxygenase isozyme 1 with its substrates, linoleic acid and oxygen, or product, 13(S)-hydroperoxy-9,11(Z,E)-octadecadienoic acid (13-HPOD), leads to the appearance of a purple color.	13(s)-hydroperoxy-9,11(z,e)-octadecadienoic acid	103-151	linoleate 9S-lipoxygenase-4	Glycine max	21-33
7742320-1	1995	Treatment of soybean lipoxygenase isozyme 1 with its substrates, linoleic acid and oxygen, or product, 13(S)-hydroperoxy-9,11(Z,E)-octadecadienoic acid (13-HPOD), leads to the appearance of a purple color.	13-Hpode	153-160	linoleate 9S-lipoxygenase-4	Glycine max	21-33
7742320-3	1995	Irradiation of frozen purple solutions of lipoxygenase causes the reversible production of a radical, shown by the effects of 2H and 17O enrichment on its EPR spectrum to be derived from 13-HPOD.	Deuterium	126-128	linoleate 9S-lipoxygenase-4	Glycine max	42-54
7742320-3	1995	Irradiation of frozen purple solutions of lipoxygenase causes the reversible production of a radical, shown by the effects of 2H and 17O enrichment on its EPR spectrum to be derived from 13-HPOD.	17o	133-136	linoleate 9S-lipoxygenase-4	Glycine max	42-54
7742320-6	1995	Taken together, these observations support the suggestion that the purple species is a complex between ferric lipoxygenase and 13-HPOD, likely the ferric peroxide.	ferric peroxide	147-162	linoleate 9S-lipoxygenase-4	Glycine max	110-122
7878664-0	1995	Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice.	Phenytoin	53-62	linoleate 9S-lipoxygenase-4	Glycine max	158-170
7878664-0	1995	Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice.	Linoleic Acid	126-139	linoleate 9S-lipoxygenase-4	Glycine max	13-25
7878664-0	1995	Evidence for lipoxygenase-catalyzed bioactivation of phenytoin to a teratogenic reactive intermediate: in vitro studies using linoleic acid-dependent soybean lipoxygenase, and in vivo studies using pregnant CD-1 mice.	Linoleic Acid	126-139	linoleate 9S-lipoxygenase-4	Glycine max	158-170
7769969-5	1995	In conclusion, PMC is more effective than alpha-Toc as an inhibitor of lipoxygenase reaction with phospholipids and of autoxidation in phospholipids.	alpha-Tocopherol	42-51	linoleate 9S-lipoxygenase-4	Glycine max	71-83
7769969-5	1995	In conclusion, PMC is more effective than alpha-Toc as an inhibitor of lipoxygenase reaction with phospholipids and of autoxidation in phospholipids.	Phospholipids	98-111	linoleate 9S-lipoxygenase-4	Glycine max	71-83
7769968-1	1995	Soybean lipoxygenase (LOX; EC 1.12.11.12) catalyzes the oxygenation of polyunsaturated fatty acids, acylglycerols and phosphoglycerols, producing a regio- and enantiospecific hydroperoxide product.	Fatty Acids, Unsaturated	71-98	linoleate 9S-lipoxygenase-4	Glycine max	8-20
7769969-6	1995	The phytyl chain of alpha-Toc seems to be unfavorable for exerting an inhibitory effect on lipoxygenase reaction with phospholipid-bile salt micelles.	Phospholipids	118-130	linoleate 9S-lipoxygenase-4	Glycine max	91-103
7769968-1	1995	Soybean lipoxygenase (LOX; EC 1.12.11.12) catalyzes the oxygenation of polyunsaturated fatty acids, acylglycerols and phosphoglycerols, producing a regio- and enantiospecific hydroperoxide product.	Fatty Acids, Unsaturated	71-98	linoleate 9S-lipoxygenase-4	Glycine max	22-25
7769969-6	1995	The phytyl chain of alpha-Toc seems to be unfavorable for exerting an inhibitory effect on lipoxygenase reaction with phospholipid-bile salt micelles.	Bile Acids and Salts	131-140	linoleate 9S-lipoxygenase-4	Glycine max	91-103
7769968-1	1995	Soybean lipoxygenase (LOX; EC 1.12.11.12) catalyzes the oxygenation of polyunsaturated fatty acids, acylglycerols and phosphoglycerols, producing a regio- and enantiospecific hydroperoxide product.	Glycerides	100-113	linoleate 9S-lipoxygenase-4	Glycine max	8-20
7819206-1	1995	The ferric form of soybean lipoxygenase catalyzes an elimination reaction on 12-iodo-cis-9-octadecenoic acid (12-IODE) to produce iodide ions and 9,11-octadecadienoic acid (9, 11-ODA).	Ferric enterobactin ion	4-10	linoleate 9S-lipoxygenase-4	Glycine max	27-39
7769968-1	1995	Soybean lipoxygenase (LOX; EC 1.12.11.12) catalyzes the oxygenation of polyunsaturated fatty acids, acylglycerols and phosphoglycerols, producing a regio- and enantiospecific hydroperoxide product.	Glycerides	100-113	linoleate 9S-lipoxygenase-4	Glycine max	22-25
7769968-1	1995	Soybean lipoxygenase (LOX; EC 1.12.11.12) catalyzes the oxygenation of polyunsaturated fatty acids, acylglycerols and phosphoglycerols, producing a regio- and enantiospecific hydroperoxide product.	phosphoglycerols	118-134	linoleate 9S-lipoxygenase-4	Glycine max	8-20
7769968-1	1995	Soybean lipoxygenase (LOX; EC 1.12.11.12) catalyzes the oxygenation of polyunsaturated fatty acids, acylglycerols and phosphoglycerols, producing a regio- and enantiospecific hydroperoxide product.	phosphoglycerols	118-134	linoleate 9S-lipoxygenase-4	Glycine max	22-25
7769968-1	1995	Soybean lipoxygenase (LOX; EC 1.12.11.12) catalyzes the oxygenation of polyunsaturated fatty acids, acylglycerols and phosphoglycerols, producing a regio- and enantiospecific hydroperoxide product.	Hydrogen Peroxide	175-188	linoleate 9S-lipoxygenase-4	Glycine max	8-20
7769968-1	1995	Soybean lipoxygenase (LOX; EC 1.12.11.12) catalyzes the oxygenation of polyunsaturated fatty acids, acylglycerols and phosphoglycerols, producing a regio- and enantiospecific hydroperoxide product.	Hydrogen Peroxide	175-188	linoleate 9S-lipoxygenase-4	Glycine max	22-25
7769968-2	1995	The goal of this work was to measure the relative rate of LOX-catalyzed oxidation of mixtures of lipids containing linoleate, using high-performance liquid chromatography (HPLC) and a light-scattering detector (LSD).	Linoleic Acid	115-124	linoleate 9S-lipoxygenase-4	Glycine max	58-61
7769969-0	1995	Effect of d-alpha-tocopherol analogues on lipoxygenase-dependent peroxidation of phospholipid-bile salt micelles.	alpha-Tocopherol	10-28	linoleate 9S-lipoxygenase-4	Glycine max	42-54
7769969-0	1995	Effect of d-alpha-tocopherol analogues on lipoxygenase-dependent peroxidation of phospholipid-bile salt micelles.	Phospholipids	81-93	linoleate 9S-lipoxygenase-4	Glycine max	42-54
7769969-0	1995	Effect of d-alpha-tocopherol analogues on lipoxygenase-dependent peroxidation of phospholipid-bile salt micelles.	Bile Acids and Salts	94-103	linoleate 9S-lipoxygenase-4	Glycine max	42-54
7819206-1	1995	The ferric form of soybean lipoxygenase catalyzes an elimination reaction on 12-iodo-cis-9-octadecenoic acid (12-IODE) to produce iodide ions and 9,11-octadecadienoic acid (9, 11-ODA).	12-Iodo-9-octadecenoic acid	77-108	linoleate 9S-lipoxygenase-4	Glycine max	27-39
7819206-1	1995	The ferric form of soybean lipoxygenase catalyzes an elimination reaction on 12-iodo-cis-9-octadecenoic acid (12-IODE) to produce iodide ions and 9,11-octadecadienoic acid (9, 11-ODA).	12-Iodo-9-octadecenoic acid	110-117	linoleate 9S-lipoxygenase-4	Glycine max	27-39
7819206-1	1995	The ferric form of soybean lipoxygenase catalyzes an elimination reaction on 12-iodo-cis-9-octadecenoic acid (12-IODE) to produce iodide ions and 9,11-octadecadienoic acid (9, 11-ODA).	Iodides	130-136	linoleate 9S-lipoxygenase-4	Glycine max	27-39
7819206-1	1995	The ferric form of soybean lipoxygenase catalyzes an elimination reaction on 12-iodo-cis-9-octadecenoic acid (12-IODE) to produce iodide ions and 9,11-octadecadienoic acid (9, 11-ODA).	9,11-linoleic acid	146-171	linoleate 9S-lipoxygenase-4	Glycine max	27-39
7819206-1	1995	The ferric form of soybean lipoxygenase catalyzes an elimination reaction on 12-iodo-cis-9-octadecenoic acid (12-IODE) to produce iodide ions and 9,11-octadecadienoic acid (9, 11-ODA).	9, 11-oda	173-182	linoleate 9S-lipoxygenase-4	Glycine max	27-39
7819206-3	1995	Ferric lipoxygenase also catalyzes the conversion of 12-bromo-cis-9-octadecenoic acid (12-BrODE) to 9,11-ODA at a rate that is less than 25% of that observed with 12-IODE.	12-bromo-9-octadecenoic acid	53-85	linoleate 9S-lipoxygenase-4	Glycine max	7-19
7819206-3	1995	Ferric lipoxygenase also catalyzes the conversion of 12-bromo-cis-9-octadecenoic acid (12-BrODE) to 9,11-ODA at a rate that is less than 25% of that observed with 12-IODE.	12-bromo-9-octadecenoic acid	87-95	linoleate 9S-lipoxygenase-4	Glycine max	7-19
7819206-3	1995	Ferric lipoxygenase also catalyzes the conversion of 12-bromo-cis-9-octadecenoic acid (12-BrODE) to 9,11-ODA at a rate that is less than 25% of that observed with 12-IODE.	9,11-oda	100-108	linoleate 9S-lipoxygenase-4	Glycine max	7-19
7819206-3	1995	Ferric lipoxygenase also catalyzes the conversion of 12-bromo-cis-9-octadecenoic acid (12-BrODE) to 9,11-ODA at a rate that is less than 25% of that observed with 12-IODE.	12-Iodo-9-octadecenoic acid	163-170	linoleate 9S-lipoxygenase-4	Glycine max	7-19
7819206-4	1995	These elimination reactions cannot be detected with ferrous lipoxygenase or with lipoxygenase that has been inactivated by 5,8,11,14-eicosatetraynoic acid.	5,8,11,14-Eicosatetraynoic Acid	123-154	linoleate 9S-lipoxygenase-4	Glycine max	81-93
7947991-3	1994	plasma membranes exhibit a lipoxygenase activity with a pH optimum in the acidic (5.5-6.0) range and with a Km value of 200 microM for both linolenic and linoleic acids.	linolenic	140-149	linoleate 9S-lipoxygenase-4	Glycine max	27-39
7989328-2	1994	The addition of water-soluble cosolvents in the reaction medium of type 1 soybean lipoxygenase can modify the selectivity of the enzyme in the hydroperoxide synthesis reaction.	Water	16-21	linoleate 9S-lipoxygenase-4	Glycine max	82-94
7989328-2	1994	The addition of water-soluble cosolvents in the reaction medium of type 1 soybean lipoxygenase can modify the selectivity of the enzyme in the hydroperoxide synthesis reaction.	Hydrogen Peroxide	143-156	linoleate 9S-lipoxygenase-4	Glycine max	82-94
7999759-6	1994	Oligonucleotide-directed mutagenesis was employed to modify residue 713 in lipoxygenase 3 which corresponds to asparagine-694 in the sequence of lipoxygenase 1.	Oligonucleotides	0-15	linoleate 9S-lipoxygenase-4	Glycine max	75-87
7999759-6	1994	Oligonucleotide-directed mutagenesis was employed to modify residue 713 in lipoxygenase 3 which corresponds to asparagine-694 in the sequence of lipoxygenase 1.	Asparagine	111-121	linoleate 9S-lipoxygenase-4	Glycine max	75-87
7999760-2	1994	The intensity of the 1s-->3d pre-edge transition of native iron(II) lipoxygenase is greater than what was found for six-coordinate high-spin iron(II) model complexes, but comparable to that of a five-coordinate model.	ammonium ferrous sulfate	62-70	linoleate 9S-lipoxygenase-4	Glycine max	71-83
7999760-4	1994	The coordination of the iron(II) in native lipoxygenase changes when methanol (as low as 0.1%) or glycerol (20%) is added to the buffer prior to freezing.	Iron	24-28	linoleate 9S-lipoxygenase-4	Glycine max	43-55
7999760-4	1994	The coordination of the iron(II) in native lipoxygenase changes when methanol (as low as 0.1%) or glycerol (20%) is added to the buffer prior to freezing.	Methanol	69-77	linoleate 9S-lipoxygenase-4	Glycine max	43-55
7999760-4	1994	The coordination of the iron(II) in native lipoxygenase changes when methanol (as low as 0.1%) or glycerol (20%) is added to the buffer prior to freezing.	Glycerol	98-106	linoleate 9S-lipoxygenase-4	Glycine max	43-55
7999760-9	1994	The iron coordination in iron(III) lipoxygenase is less affected by the presence of alcohols than is the site in the iron(II) enzyme.	Iron	4-8	linoleate 9S-lipoxygenase-4	Glycine max	35-47
7999760-9	1994	The iron coordination in iron(III) lipoxygenase is less affected by the presence of alcohols than is the site in the iron(II) enzyme.	Alcohols	84-92	linoleate 9S-lipoxygenase-4	Glycine max	35-47
7999760-9	1994	The iron coordination in iron(III) lipoxygenase is less affected by the presence of alcohols than is the site in the iron(II) enzyme.	Iron	25-29	linoleate 9S-lipoxygenase-4	Glycine max	35-47
7947991-3	1994	plasma membranes exhibit a lipoxygenase activity with a pH optimum in the acidic (5.5-6.0) range and with a Km value of 200 microM for both linolenic and linoleic acids.	Linoleic Acids	154-168	linoleate 9S-lipoxygenase-4	Glycine max	27-39
7947991-9	1994	The plasma membrane vesicles also show a lipoxygenase, active in the alkaline (9.0-9.5) range, inhibited by NDGA, SHAM and propyl gallate, stimulated by H2O2, but with a lower Km value (60 microM) and less sensitive to calcium stimulation than the acidic one.	Masoprocol	108-112	linoleate 9S-lipoxygenase-4	Glycine max	41-53
7947748-1	1994	It has been proposed that catechols and other antioxidants inhibit lipoxygenase activity by reducing the active Fe3+ form of the enzyme [Kemal et al.	Catechols	26-35	linoleate 9S-lipoxygenase-4	Glycine max	67-79
7947991-9	1994	The plasma membrane vesicles also show a lipoxygenase, active in the alkaline (9.0-9.5) range, inhibited by NDGA, SHAM and propyl gallate, stimulated by H2O2, but with a lower Km value (60 microM) and less sensitive to calcium stimulation than the acidic one.	Propyl Gallate	123-137	linoleate 9S-lipoxygenase-4	Glycine max	41-53
7947748-1	1994	It has been proposed that catechols and other antioxidants inhibit lipoxygenase activity by reducing the active Fe3+ form of the enzyme [Kemal et al.	ferric sulfate	112-116	linoleate 9S-lipoxygenase-4	Glycine max	67-79
7947748-3	1994	In this model, reductively inactivated lipoxygenase can be reactivated by reaction with the hydroperoxide product in a pseudoperoxidase reaction.	Hydrogen Peroxide	92-105	linoleate 9S-lipoxygenase-4	Glycine max	39-51
7947991-9	1994	The plasma membrane vesicles also show a lipoxygenase, active in the alkaline (9.0-9.5) range, inhibited by NDGA, SHAM and propyl gallate, stimulated by H2O2, but with a lower Km value (60 microM) and less sensitive to calcium stimulation than the acidic one.	Hydrogen Peroxide	153-157	linoleate 9S-lipoxygenase-4	Glycine max	41-53
7947748-8	1994	A rate equation for the lipoxygenase-catalyzed reaction in the presence of reducing agent was derived considering that the inhibition of the oxygenase reaction is the combined result of 13-HpODE consumption and formation of inactive Fe2+ enzyme due to occurrence of the pseudoperoxidase reaction.	13-hydroperoxy-9,11-octadecadienoic acid	186-194	linoleate 9S-lipoxygenase-4	Glycine max	24-36
7947991-9	1994	The plasma membrane vesicles also show a lipoxygenase, active in the alkaline (9.0-9.5) range, inhibited by NDGA, SHAM and propyl gallate, stimulated by H2O2, but with a lower Km value (60 microM) and less sensitive to calcium stimulation than the acidic one.	Calcium	219-226	linoleate 9S-lipoxygenase-4	Glycine max	41-53
8188678-1	1994	Two types of 12-lipoxygenase that catalyze the transformation of arachidonic acid to 12(S)-hydroperoxyeicosatetraenoic acid (12-HPETE) have been previously classified into platelet-type and leukocyte-type categories.	Arachidonic Acid	65-81	linoleate 9S-lipoxygenase-4	Glycine max	16-28
8090060-4	1994	Linoleic acid is converted by lipoxygenase to the corresponding hydroperoxide that oxidizes the F-acid, probably in a radical reaction, to form an unstable dioxoene compound.	Linoleic Acid	0-13	linoleate 9S-lipoxygenase-4	Glycine max	30-42
8090060-4	1994	Linoleic acid is converted by lipoxygenase to the corresponding hydroperoxide that oxidizes the F-acid, probably in a radical reaction, to form an unstable dioxoene compound.	Hydrogen Peroxide	64-77	linoleate 9S-lipoxygenase-4	Glycine max	30-42
8090060-4	1994	Linoleic acid is converted by lipoxygenase to the corresponding hydroperoxide that oxidizes the F-acid, probably in a radical reaction, to form an unstable dioxoene compound.	Fatty Acids	96-102	linoleate 9S-lipoxygenase-4	Glycine max	30-42
8090060-4	1994	Linoleic acid is converted by lipoxygenase to the corresponding hydroperoxide that oxidizes the F-acid, probably in a radical reaction, to form an unstable dioxoene compound.	dioxoene	156-164	linoleate 9S-lipoxygenase-4	Glycine max	30-42
8073088-4	1994	In this study, inhibition of prostaglandin synthetase (bovine seminal vesicular microsomes) by hydroxyachillin required concentrations more than twice those which inhibited soybean lipoxygenase (ED50 values = 10(-4) M and 2.6 x 10(-5) M, respectively).	hydroxyachillin	95-110	linoleate 9S-lipoxygenase-4	Glycine max	181-193
7943384-1	1994	The accumulation of arachidonic acid and lipoxygenase metabolites of arachidonate occurs in ischemic-reperfused myocardium.	Arachidonic Acid	69-81	linoleate 9S-lipoxygenase-4	Glycine max	41-53
7943384-4	1994	Although neither arachidonic acid nor lipoxygenase alone had any effects, arachidonic acid plus lipoxygenase induced an increase in the twitch amplitude associated with an increased intracellular Ca2+ concentration ([Ca2+]i) and irreversible hypercontracture.	Arachidonic Acid	17-33	linoleate 9S-lipoxygenase-4	Glycine max	96-108
7943384-5	1994	Nordihydroguaiaretic acid, a lipoxygenase inhibitor, blocked these effects.	Masoprocol	0-25	linoleate 9S-lipoxygenase-4	Glycine max	29-41
7943384-6	1994	Linolenic acid, which is also a lipoxygenase substrate, caused the same effects as arachidonic acid in the presence of lipoxygenase, whereas oleic and stearic acid, which do not function as lipoxygenase substrates, did not.	alpha-Linolenic Acid	0-14	linoleate 9S-lipoxygenase-4	Glycine max	32-44
7943384-6	1994	Linolenic acid, which is also a lipoxygenase substrate, caused the same effects as arachidonic acid in the presence of lipoxygenase, whereas oleic and stearic acid, which do not function as lipoxygenase substrates, did not.	Arachidonic Acid	83-99	linoleate 9S-lipoxygenase-4	Glycine max	32-44
7943384-6	1994	Linolenic acid, which is also a lipoxygenase substrate, caused the same effects as arachidonic acid in the presence of lipoxygenase, whereas oleic and stearic acid, which do not function as lipoxygenase substrates, did not.	Arachidonic Acid	83-99	linoleate 9S-lipoxygenase-4	Glycine max	119-131
7943384-6	1994	Linolenic acid, which is also a lipoxygenase substrate, caused the same effects as arachidonic acid in the presence of lipoxygenase, whereas oleic and stearic acid, which do not function as lipoxygenase substrates, did not.	Arachidonic Acid	83-99	linoleate 9S-lipoxygenase-4	Glycine max	119-131
7943384-6	1994	Linolenic acid, which is also a lipoxygenase substrate, caused the same effects as arachidonic acid in the presence of lipoxygenase, whereas oleic and stearic acid, which do not function as lipoxygenase substrates, did not.	oleic	141-146	linoleate 9S-lipoxygenase-4	Glycine max	32-44
7943384-8	1994	These results suggest that lipoxygenase metabolites of arachidonic acid cause intracellular Ca2+ overload and cellular damage to cardiomyocytes, probably through augmentation of lipid peroxidation of the cell membranes by free radicals.	Arachidonic Acid	55-71	linoleate 9S-lipoxygenase-4	Glycine max	27-39
7918597-0	1994	Superoxide generation by lipoxygenase in the presence of NADH and NADPH.	Superoxides	0-10	linoleate 9S-lipoxygenase-4	Glycine max	25-37
7918597-0	1994	Superoxide generation by lipoxygenase in the presence of NADH and NADPH.	NAD	57-61	linoleate 9S-lipoxygenase-4	Glycine max	25-37
7918597-0	1994	Superoxide generation by lipoxygenase in the presence of NADH and NADPH.	NADP	66-71	linoleate 9S-lipoxygenase-4	Glycine max	25-37
7918597-1	1994	The ability of soybean lipoxygenase to mediate NAD(P)H oxidation and concomitant superoxide generation in the presence of linoleic acid was examined.	Superoxides	81-91	linoleate 9S-lipoxygenase-4	Glycine max	23-35
7918597-1	1994	The ability of soybean lipoxygenase to mediate NAD(P)H oxidation and concomitant superoxide generation in the presence of linoleic acid was examined.	Linoleic Acid	122-135	linoleate 9S-lipoxygenase-4	Glycine max	23-35
7918597-2	1994	At optimum pH of 8.3, lipoxygenase oxidized both NADH and NADPH in the presence of 700 microM linoleic acid.	NAD	49-53	linoleate 9S-lipoxygenase-4	Glycine max	22-34
7918597-2	1994	At optimum pH of 8.3, lipoxygenase oxidized both NADH and NADPH in the presence of 700 microM linoleic acid.	NADP	58-63	linoleate 9S-lipoxygenase-4	Glycine max	22-34
7918597-2	1994	At optimum pH of 8.3, lipoxygenase oxidized both NADH and NADPH in the presence of 700 microM linoleic acid.	Linoleic Acid	94-107	linoleate 9S-lipoxygenase-4	Glycine max	22-34
7918597-11	1994	These results strongly suggest that lipoxygenase not only generates lipid hydroperoxides but can also generate superoxide via oxidation of pyridine nucleotides and may, therefore, significantly contribute to oxidative stress in cells.	Lipid Peroxides	68-88	linoleate 9S-lipoxygenase-4	Glycine max	36-48
7918597-11	1994	These results strongly suggest that lipoxygenase not only generates lipid hydroperoxides but can also generate superoxide via oxidation of pyridine nucleotides and may, therefore, significantly contribute to oxidative stress in cells.	Superoxides	111-121	linoleate 9S-lipoxygenase-4	Glycine max	36-48
7918597-11	1994	These results strongly suggest that lipoxygenase not only generates lipid hydroperoxides but can also generate superoxide via oxidation of pyridine nucleotides and may, therefore, significantly contribute to oxidative stress in cells.	pyridine nucleotides	139-159	linoleate 9S-lipoxygenase-4	Glycine max	36-48
7918601-0	1994	Lipoxygenase-catalyzed oxidation of chlorpromazine by hydrogen peroxide at acidic pH.	Chlorpromazine	36-50	linoleate 9S-lipoxygenase-4	Glycine max	0-12
7918601-0	1994	Lipoxygenase-catalyzed oxidation of chlorpromazine by hydrogen peroxide at acidic pH.	Hydrogen Peroxide	54-71	linoleate 9S-lipoxygenase-4	Glycine max	0-12
7918601-1	1994	The hydroperoxidase activity of soybean lipoxygenase, a non-heme protein, oxidizes chlorpromazine using H2O2 at acidic pHs ranging from 3.0 to 4.0.	Chlorpromazine	83-97	linoleate 9S-lipoxygenase-4	Glycine max	40-52
7918601-1	1994	The hydroperoxidase activity of soybean lipoxygenase, a non-heme protein, oxidizes chlorpromazine using H2O2 at acidic pHs ranging from 3.0 to 4.0.	Hydrogen Peroxide	104-108	linoleate 9S-lipoxygenase-4	Glycine max	40-52
7918601-7	1994	The radical cation obtained in the oxidation of chlorpromazine by lipoxygenase decays by a disproportionation reaction.	Chlorpromazine	48-62	linoleate 9S-lipoxygenase-4	Glycine max	66-78
8073088-3	1994	In the experimental models in vitro, hydroxyachillin has been reported to be a dual inhibitor of cyclooxygenase and soybean lipoxygenase.	hydroxyachillin	37-52	linoleate 9S-lipoxygenase-4	Glycine max	124-136
8188678-1	1994	Two types of 12-lipoxygenase that catalyze the transformation of arachidonic acid to 12(S)-hydroperoxyeicosatetraenoic acid (12-HPETE) have been previously classified into platelet-type and leukocyte-type categories.	12(s)-hydroperoxyeicosatetraenoic acid	85-123	linoleate 9S-lipoxygenase-4	Glycine max	16-28
8188678-7	1994	Mutagenesis and deletion of the highly conserved lipoxygenase C-terminal isoleucine (Ile663), a residue believed to be involved in the non-heme iron atom coordination of all lipoxygenases, was performed.	Isoleucine	73-83	linoleate 9S-lipoxygenase-4	Glycine max	49-61
8188678-7	1994	Mutagenesis and deletion of the highly conserved lipoxygenase C-terminal isoleucine (Ile663), a residue believed to be involved in the non-heme iron atom coordination of all lipoxygenases, was performed.	Heme	139-143	linoleate 9S-lipoxygenase-4	Glycine max	49-61
8188678-7	1994	Mutagenesis and deletion of the highly conserved lipoxygenase C-terminal isoleucine (Ile663), a residue believed to be involved in the non-heme iron atom coordination of all lipoxygenases, was performed.	Iron	144-148	linoleate 9S-lipoxygenase-4	Glycine max	49-61
8188678-10	1994	These findings would tend to indicate a stringent requirement for the proper spatial alignment and folding of the C-terminal chain back into the core of the enzyme to interact with the iron atom by analogy with the recently determined crystal structure of a soybean lipoxygenase (Boyington, J. C., Gaffney, B. J., and Amzel, L. M. (1993) Science 260, 1482-1486).	Iron	185-189	linoleate 9S-lipoxygenase-4	Glycine max	266-278
8218349-0	1993	Lipoxygenase in soybean seedlings catalyzes the oxygenation of phospholipid and such activity changes after treatment with fungal elicitor.	Phospholipids	63-75	linoleate 9S-lipoxygenase-4	Glycine max	0-12
8166703-0	1994	Lipoxygenase-catalyzed oxidation of catecholamines.	Catecholamines	36-50	linoleate 9S-lipoxygenase-4	Glycine max	0-12
8166703-1	1994	Dopa and structurally related catecholamines in presence of hydrogen peroxide are oxidized in vitro by soybean lipoxygenase producing the corresponding melanin pigments.	Dihydroxyphenylalanine	0-4	linoleate 9S-lipoxygenase-4	Glycine max	111-123
8166703-1	1994	Dopa and structurally related catecholamines in presence of hydrogen peroxide are oxidized in vitro by soybean lipoxygenase producing the corresponding melanin pigments.	Catecholamines	30-44	linoleate 9S-lipoxygenase-4	Glycine max	111-123
8166703-1	1994	Dopa and structurally related catecholamines in presence of hydrogen peroxide are oxidized in vitro by soybean lipoxygenase producing the corresponding melanin pigments.	Hydrogen Peroxide	60-77	linoleate 9S-lipoxygenase-4	Glycine max	111-123
8166703-1	1994	Dopa and structurally related catecholamines in presence of hydrogen peroxide are oxidized in vitro by soybean lipoxygenase producing the corresponding melanin pigments.	Melanins	152-159	linoleate 9S-lipoxygenase-4	Glycine max	111-123
7922137-2	1994	In harmony with our studies on the activation of hydrocarbons by Gif chemistry, we have, in the first part of this paper, studied the mechanism of the lipoxygenase enzymes using soybean lipoxygenase as a model.	Hydrocarbons	49-61	linoleate 9S-lipoxygenase-4	Glycine max	151-163
8177015-1	1994	In many studies on lipoxygenase catalysis, nonionic detergents are used to obtain an optically transparent solution of the fatty acid substrate.	Fatty Acids	123-133	linoleate 9S-lipoxygenase-4	Glycine max	19-31
8177015-3	1994	However, at high linoleate concentrations, where substrate inhibition of lipoxygenase is significant, small amounts of detergent increased the dioxygenation rate.	Linoleic Acid	17-26	linoleate 9S-lipoxygenase-4	Glycine max	73-85
8177015-6	1994	The conclusions that monomeric, nonmicellar linoleate is the preferred substrate for lipoxygenase and that the observed inhibition and stimulation are solely due to changes in the effective linoleate concentration strongly corroborate the earlier observations by Galpin and Allen [Biochim.	Linoleic Acid	44-53	linoleate 9S-lipoxygenase-4	Glycine max	85-97
8033289-1	1994	The interaction of furan fatty acids (F-acids) with lipoxygenase was investigated by incubation experiments of a synthetic dialkyl-substituted F-acid with soybean lipoxygenase-1.	furan fatty acids	19-36	linoleate 9S-lipoxygenase-4	Glycine max	52-64
8033289-1	1994	The interaction of furan fatty acids (F-acids) with lipoxygenase was investigated by incubation experiments of a synthetic dialkyl-substituted F-acid with soybean lipoxygenase-1.	Fatty Acids	38-45	linoleate 9S-lipoxygenase-4	Glycine max	52-64
8033289-1	1994	The interaction of furan fatty acids (F-acids) with lipoxygenase was investigated by incubation experiments of a synthetic dialkyl-substituted F-acid with soybean lipoxygenase-1.	dialkyl-substituted f-acid	123-149	linoleate 9S-lipoxygenase-4	Glycine max	52-64
8033289-2	1994	Originally the oxidation of furan fatty acids was assumed to be directly effected by lipoxygenase.	furan fatty acids	28-45	linoleate 9S-lipoxygenase-4	Glycine max	85-97
8033289-3	1994	It is now demonstrated that this reaction is a two-step process that requires the presence of lipoxygenase substrates, e.g. linoleic acid.	Linoleic Acid	124-137	linoleate 9S-lipoxygenase-4	Glycine max	94-106
8142401-3	1994	In reactions started with 1.3 microM iron (II) lipoxygenase and 9 microM linoleate, the initial rate, r(init) (estimated from the increase in absorbance over the initial 0.02 s of the reaction), is very small (4 s-1).	Linoleic Acid	73-82	linoleate 9S-lipoxygenase-4	Glycine max	47-59
8142401-5	1994	In reactions started with mixtures of iron(II) and iron(III) lipoxygenase, r(init) is linearly related to the initial concentration of the Fe (III) enzyme form.	Iron	38-42	linoleate 9S-lipoxygenase-4	Glycine max	61-73
8142401-5	1994	In reactions started with mixtures of iron(II) and iron(III) lipoxygenase, r(init) is linearly related to the initial concentration of the Fe (III) enzyme form.	fe (iii)	139-147	linoleate 9S-lipoxygenase-4	Glycine max	61-73
8142401-7	1994	The observations provide solid evidence for the hypothesis that only iron (III) lipoxygenase can catalyze the hydrogen abstraction step in the dioxygenation reaction, and thus can be regarded as the active enzyme species.	Hydrogen	110-118	linoleate 9S-lipoxygenase-4	Glycine max	80-92
8218349-1	1993	Lipoxygenase (LOX) activities in the crude extracts of soybean cotyledons on phospholipid were measured by a chemiluminescence (CL) assay system.	Phospholipids	77-89	linoleate 9S-lipoxygenase-4	Glycine max	0-12
8218349-1	1993	Lipoxygenase (LOX) activities in the crude extracts of soybean cotyledons on phospholipid were measured by a chemiluminescence (CL) assay system.	Phospholipids	77-89	linoleate 9S-lipoxygenase-4	Glycine max	14-17
8218349-2	1993	The activity of LOX on phospholipid increased at 6 h after treatment with fungal elicitor, whereas the activity in the control experiment without elicitor treatment declined with incubation.	Phospholipids	23-35	linoleate 9S-lipoxygenase-4	Glycine max	16-19
8218349-4	1993	The LOX fraction obtained from soybean cotyledons at 6 h after elicitation by a DEAE column chromatography was reacted with 1-palmitoyl-2-linoleoyl-phosphatidylcholine substrate.	2-diethylaminoethanol	80-84	linoleate 9S-lipoxygenase-4	Glycine max	4-7
8218349-4	1993	The LOX fraction obtained from soybean cotyledons at 6 h after elicitation by a DEAE column chromatography was reacted with 1-palmitoyl-2-linoleoyl-phosphatidylcholine substrate.	1-palmitoyl-2-linoleoylphosphatidylcholine	124-167	linoleate 9S-lipoxygenase-4	Glycine max	4-7
8364403-6	1993	When bovine rumen fluid was used as a source of carotenoid for in vitro studies with preparations of lipoxygenase, a rapid decrease in carotenoid and chlorophyll concentrations was observed, again requiring the addition of linoleic acid.	Carotenoids	48-58	linoleate 9S-lipoxygenase-4	Glycine max	101-113
24248580-0	1993	Lipoxygenase-derived aldehydes inhibit fungi pathogenic on soybean.	Aldehydes	21-30	linoleate 9S-lipoxygenase-4	Glycine max	0-12
24248580-1	1993	Several unsaturated aldehydes are produced from polyunsaturated fatty acids via the lipoxygenase pathway when soybean (Glycine max) plants are wounded mechanically or by pathogens.	unsaturated aldehydes	8-29	linoleate 9S-lipoxygenase-4	Glycine max	84-96
24248580-1	1993	Several unsaturated aldehydes are produced from polyunsaturated fatty acids via the lipoxygenase pathway when soybean (Glycine max) plants are wounded mechanically or by pathogens.	Fatty Acids, Unsaturated	48-75	linoleate 9S-lipoxygenase-4	Glycine max	84-96
8347579-6	1993	The integrated steady-state rate equation for the single fatty acid binding site model of lipoxygenase catalysis [Schilstra et al.	Fatty Acids	57-67	linoleate 9S-lipoxygenase-4	Glycine max	90-102
8347579-10	1993	From a nonlinear least-squares fit to the steady-state rate equation of data obtained at lipoxygenase concentrations of 0.5 and 1 nM, it was calculated that 1% of the linoleate radicals that are formed after hydrogen abstraction dissociate from the active site before enzymic oxygen insertion has occurred.	Linoleic Acid	167-176	linoleate 9S-lipoxygenase-4	Glycine max	89-101
8347579-10	1993	From a nonlinear least-squares fit to the steady-state rate equation of data obtained at lipoxygenase concentrations of 0.5 and 1 nM, it was calculated that 1% of the linoleate radicals that are formed after hydrogen abstraction dissociate from the active site before enzymic oxygen insertion has occurred.	Hydrogen	208-216	linoleate 9S-lipoxygenase-4	Glycine max	89-101
8364403-6	1993	When bovine rumen fluid was used as a source of carotenoid for in vitro studies with preparations of lipoxygenase, a rapid decrease in carotenoid and chlorophyll concentrations was observed, again requiring the addition of linoleic acid.	Carotenoids	135-145	linoleate 9S-lipoxygenase-4	Glycine max	101-113
8364403-6	1993	When bovine rumen fluid was used as a source of carotenoid for in vitro studies with preparations of lipoxygenase, a rapid decrease in carotenoid and chlorophyll concentrations was observed, again requiring the addition of linoleic acid.	Chlorophyll	150-161	linoleate 9S-lipoxygenase-4	Glycine max	101-113
8364403-6	1993	When bovine rumen fluid was used as a source of carotenoid for in vitro studies with preparations of lipoxygenase, a rapid decrease in carotenoid and chlorophyll concentrations was observed, again requiring the addition of linoleic acid.	Linoleic Acid	223-236	linoleate 9S-lipoxygenase-4	Glycine max	101-113
8364403-9	1993	The inclusion of dietary sources of lipoxygenase may be an effective method for controlling carotenoid uptake in certain ruminant species.	Carotenoids	92-102	linoleate 9S-lipoxygenase-4	Glycine max	36-48
8431429-1	1993	We have measured, under identical conditions, the time courses for the native lipoxygenase (Fe2+ form)-catalyzed conversion of linoleic acid into 13-hydroperoxy-9,11-octadecadienoic acid (HPOD) and the oxidation of the Fe2+ form of enzyme to the Fe3+ form (in 0.1 M borate buffer, pH 10.0, at 25 degrees C) using a stopped-flow spectrophoto/fluorometer.	ammonium ferrous sulfate	92-96	linoleate 9S-lipoxygenase-4	Glycine max	78-90
8481396-0	1993	The interaction between beta-carotene and lipoxygenase in plant and animal systems.	beta Carotene	24-37	linoleate 9S-lipoxygenase-4	Glycine max	42-54
8481396-1	1993	The effect of beta-carotene (BC) on the activity of lipoxygenase (LOX) from plant and animal sources has been examined.	beta Carotene	14-27	linoleate 9S-lipoxygenase-4	Glycine max	52-64
8481396-1	1993	The effect of beta-carotene (BC) on the activity of lipoxygenase (LOX) from plant and animal sources has been examined.	beta Carotene	14-27	linoleate 9S-lipoxygenase-4	Glycine max	66-69
8481396-1	1993	The effect of beta-carotene (BC) on the activity of lipoxygenase (LOX) from plant and animal sources has been examined.	beta Carotene	29-31	linoleate 9S-lipoxygenase-4	Glycine max	52-64
8481396-1	1993	The effect of beta-carotene (BC) on the activity of lipoxygenase (LOX) from plant and animal sources has been examined.	beta Carotene	29-31	linoleate 9S-lipoxygenase-4	Glycine max	66-69
8481396-2	1993	Soybean lipoxygenase L-2 activity towards linoleate was inhibited by BC by a maximum of 70% at pH 6.5, whereas L-1 activity was little affected at pH 9.0.	Linoleic Acid	42-51	linoleate 9S-lipoxygenase-4	Glycine max	8-20
8481396-3	1993	Lineweaver-Burk plots indicated that BC inhibited LOX activity by mixed competitive/non-competitive mechanisms.	beta Carotene	37-39	linoleate 9S-lipoxygenase-4	Glycine max	50-53
8481396-4	1993	Other hydrophobic compounds also inhibited LOX activity; oleic acid and retinol were competitive inhibitors whereas tocopherol acetate and 5,8,11,14-eicosatetraynoic acid (ETYA) were non-competitive inhibitors.	Oleic Acid	57-67	linoleate 9S-lipoxygenase-4	Glycine max	43-46
8481396-4	1993	Other hydrophobic compounds also inhibited LOX activity; oleic acid and retinol were competitive inhibitors whereas tocopherol acetate and 5,8,11,14-eicosatetraynoic acid (ETYA) were non-competitive inhibitors.	Vitamin A	72-79	linoleate 9S-lipoxygenase-4	Glycine max	43-46
8481396-4	1993	Other hydrophobic compounds also inhibited LOX activity; oleic acid and retinol were competitive inhibitors whereas tocopherol acetate and 5,8,11,14-eicosatetraynoic acid (ETYA) were non-competitive inhibitors.	alpha-Tocopherol	116-134	linoleate 9S-lipoxygenase-4	Glycine max	43-46
8481396-4	1993	Other hydrophobic compounds also inhibited LOX activity; oleic acid and retinol were competitive inhibitors whereas tocopherol acetate and 5,8,11,14-eicosatetraynoic acid (ETYA) were non-competitive inhibitors.	5,8,11,14-Eicosatetraynoic Acid	139-170	linoleate 9S-lipoxygenase-4	Glycine max	43-46
8481396-4	1993	Other hydrophobic compounds also inhibited LOX activity; oleic acid and retinol were competitive inhibitors whereas tocopherol acetate and 5,8,11,14-eicosatetraynoic acid (ETYA) were non-competitive inhibitors.	5,8,11,14-Eicosatetraynoic Acid	172-176	linoleate 9S-lipoxygenase-4	Glycine max	43-46
8481396-5	1993	Binding studies with L-2 LOX bound to Sepharose indicated BC-binding and inhibition with the immobilized LOX.	Sepharose	38-47	linoleate 9S-lipoxygenase-4	Glycine max	25-28
8481396-5	1993	Binding studies with L-2 LOX bound to Sepharose indicated BC-binding and inhibition with the immobilized LOX.	Sepharose	38-47	linoleate 9S-lipoxygenase-4	Glycine max	105-108
8481396-6	1993	Activity of LOX from animal sources was also inhibited by BC both towards linoleate and arachidonate.	Linoleic Acid	74-83	linoleate 9S-lipoxygenase-4	Glycine max	12-15
8481396-6	1993	Activity of LOX from animal sources was also inhibited by BC both towards linoleate and arachidonate.	Arachidonic Acid	88-100	linoleate 9S-lipoxygenase-4	Glycine max	12-15
8507674-7	1993	Using this method the structures of epoxy, hydroxy derivatives of 4,7,10,13,16,19-docosahexaenoic acid (22:6w3) formed by soybean lipoxygenase were determined.	Docosahexaenoic Acids	66-102	linoleate 9S-lipoxygenase-4	Glycine max	130-142
8464355-0	1993	Simultaneous determination of the main molecular species of soybean phosphatidylcholine or phosphatidylethanolamine and their corresponding hydroperoxides obtained by lipoxygenase treatment.	Phosphatidylcholines	68-87	linoleate 9S-lipoxygenase-4	Glycine max	167-179
8464355-0	1993	Simultaneous determination of the main molecular species of soybean phosphatidylcholine or phosphatidylethanolamine and their corresponding hydroperoxides obtained by lipoxygenase treatment.	phosphatidylethanolamine	91-115	linoleate 9S-lipoxygenase-4	Glycine max	167-179
8464355-0	1993	Simultaneous determination of the main molecular species of soybean phosphatidylcholine or phosphatidylethanolamine and their corresponding hydroperoxides obtained by lipoxygenase treatment.	Hydrogen Peroxide	140-154	linoleate 9S-lipoxygenase-4	Glycine max	167-179
8464355-2	1993	Hydroperoxides were formed by incubation of phospholipids with lipoxygenase at pH 9.2.	Hydrogen Peroxide	0-14	linoleate 9S-lipoxygenase-4	Glycine max	63-75
8464355-2	1993	Hydroperoxides were formed by incubation of phospholipids with lipoxygenase at pH 9.2.	Phospholipids	44-57	linoleate 9S-lipoxygenase-4	Glycine max	63-75
8431429-1	1993	We have measured, under identical conditions, the time courses for the native lipoxygenase (Fe2+ form)-catalyzed conversion of linoleic acid into 13-hydroperoxy-9,11-octadecadienoic acid (HPOD) and the oxidation of the Fe2+ form of enzyme to the Fe3+ form (in 0.1 M borate buffer, pH 10.0, at 25 degrees C) using a stopped-flow spectrophoto/fluorometer.	Linoleic Acid	127-140	linoleate 9S-lipoxygenase-4	Glycine max	78-90
8431429-1	1993	We have measured, under identical conditions, the time courses for the native lipoxygenase (Fe2+ form)-catalyzed conversion of linoleic acid into 13-hydroperoxy-9,11-octadecadienoic acid (HPOD) and the oxidation of the Fe2+ form of enzyme to the Fe3+ form (in 0.1 M borate buffer, pH 10.0, at 25 degrees C) using a stopped-flow spectrophoto/fluorometer.	13-hydroperoxy-9,11-octadecadienoic acid	146-186	linoleate 9S-lipoxygenase-4	Glycine max	78-90
8431429-1	1993	We have measured, under identical conditions, the time courses for the native lipoxygenase (Fe2+ form)-catalyzed conversion of linoleic acid into 13-hydroperoxy-9,11-octadecadienoic acid (HPOD) and the oxidation of the Fe2+ form of enzyme to the Fe3+ form (in 0.1 M borate buffer, pH 10.0, at 25 degrees C) using a stopped-flow spectrophoto/fluorometer.	13-hydroperoxy-9,11-octadecadienoic acid	188-192	linoleate 9S-lipoxygenase-4	Glycine max	78-90
8431429-1	1993	We have measured, under identical conditions, the time courses for the native lipoxygenase (Fe2+ form)-catalyzed conversion of linoleic acid into 13-hydroperoxy-9,11-octadecadienoic acid (HPOD) and the oxidation of the Fe2+ form of enzyme to the Fe3+ form (in 0.1 M borate buffer, pH 10.0, at 25 degrees C) using a stopped-flow spectrophoto/fluorometer.	ammonium ferrous sulfate	219-223	linoleate 9S-lipoxygenase-4	Glycine max	78-90
8431429-1	1993	We have measured, under identical conditions, the time courses for the native lipoxygenase (Fe2+ form)-catalyzed conversion of linoleic acid into 13-hydroperoxy-9,11-octadecadienoic acid (HPOD) and the oxidation of the Fe2+ form of enzyme to the Fe3+ form (in 0.1 M borate buffer, pH 10.0, at 25 degrees C) using a stopped-flow spectrophoto/fluorometer.	ferric sulfate	246-250	linoleate 9S-lipoxygenase-4	Glycine max	78-90
8431429-1	1993	We have measured, under identical conditions, the time courses for the native lipoxygenase (Fe2+ form)-catalyzed conversion of linoleic acid into 13-hydroperoxy-9,11-octadecadienoic acid (HPOD) and the oxidation of the Fe2+ form of enzyme to the Fe3+ form (in 0.1 M borate buffer, pH 10.0, at 25 degrees C) using a stopped-flow spectrophoto/fluorometer.	Borates	266-272	linoleate 9S-lipoxygenase-4	Glycine max	78-90
27280998-0	1993	Synthesis of (+)-Turmeronol A, an Inhibitor of Soybean Lipoxygenase, and (+)-ar-Turmerone.	(+)-turmeronol a	13-29	linoleate 9S-lipoxygenase-4	Glycine max	55-67
16652980-6	1992	Electron microscopy of the methyl jasmonate-responsive lipoxygenase protein in the vacuoles showed that it was arranged into a stellate, paracrystalline structure in various cell types other than the paraveinal mesophyll cells.	methyl jasmonate	27-43	linoleate 9S-lipoxygenase-4	Glycine max	55-67
16653005-9	1992	In the in vivo lipoxygenase substrate pool, the linoleic acid level declined and the relative level of linolenic acid increased.	Linoleic Acid	48-61	linoleate 9S-lipoxygenase-4	Glycine max	15-27
16652980-0	1992	Expression, activity, and cellular accumulation of methyl jasmonate-responsive lipoxygenase in soybean seedlings.	methyl jasmonate	51-67	linoleate 9S-lipoxygenase-4	Glycine max	79-91
16653005-9	1992	In the in vivo lipoxygenase substrate pool, the linoleic acid level declined and the relative level of linolenic acid increased.	alpha-Linolenic Acid	103-117	linoleate 9S-lipoxygenase-4	Glycine max	15-27
16652980-1	1992	Exposure of soybean (Glycine max) seedlings to low levels of atmospheric methyl jasmonate induced the expression and accumulation of one or more lipoxygenase(s) in the primary leaves, hypocotyls, epicotyls, and cotyledons.	methyl jasmonate	73-89	linoleate 9S-lipoxygenase-4	Glycine max	145-157
16652980-2	1992	In the primary leaf, the major site of lipoxygenase accumulation in response to methyl jasmonate was in the vacuoles of paraveinal mesophyll cells.	methyl jasmonate	80-96	linoleate 9S-lipoxygenase-4	Glycine max	39-51
1510955-0	1992	Effect of lipid hydroperoxide on lipoxygenase kinetics.	Lipid Peroxides	10-29	linoleate 9S-lipoxygenase-4	Glycine max	33-45
16652980-5	1992	Both spectrophotometric measurement of conjugated diene formation and thin layer chromatography of lipoxygenase product formation indicated that methyl jasmonate caused an increase in the amount of lipoxygenase activity.	diene	50-55	linoleate 9S-lipoxygenase-4	Glycine max	198-210
16652980-5	1992	Both spectrophotometric measurement of conjugated diene formation and thin layer chromatography of lipoxygenase product formation indicated that methyl jasmonate caused an increase in the amount of lipoxygenase activity.	methyl jasmonate	145-161	linoleate 9S-lipoxygenase-4	Glycine max	99-111
16652980-5	1992	Both spectrophotometric measurement of conjugated diene formation and thin layer chromatography of lipoxygenase product formation indicated that methyl jasmonate caused an increase in the amount of lipoxygenase activity.	methyl jasmonate	145-161	linoleate 9S-lipoxygenase-4	Glycine max	198-210
1510955-2	1992	The following observations were made: (1) Iron(II) and iron(III) lipoxygenases are kinetically different: reactions started with the Fe(II) enzyme form show a lag phase, whereas iron(III) lipoxygenase induces an initial burst.	ammonium ferrous sulfate	133-139	linoleate 9S-lipoxygenase-4	Glycine max	65-77
1579592-5	1992	To investigate the potential significance of these reactions to biological systems, we have used soybean lipoxygenase to generate peroxyl radical enzymatically.	perhydroxyl radical	130-145	linoleate 9S-lipoxygenase-4	Glycine max	105-117
1579592-6	1992	beta-Carotene inhibits the oxidation of linoleic acid by soybean lipoxygenase as well as the formation of the hydroperoxide product.	beta Carotene	0-13	linoleate 9S-lipoxygenase-4	Glycine max	65-77
1579592-6	1992	beta-Carotene inhibits the oxidation of linoleic acid by soybean lipoxygenase as well as the formation of the hydroperoxide product.	Linoleic Acid	40-53	linoleate 9S-lipoxygenase-4	Glycine max	65-77
1579592-7	1992	In addition, the absorption of beta-carotene is diminished (bleached) by soybean lipoxygenase.	beta Carotene	31-44	linoleate 9S-lipoxygenase-4	Glycine max	81-93
1315759-0	1992	Nitroxide metabolites from alkylhydroxylamines and N-hydroxyurea derivatives resulting from reductive inhibition of soybean lipoxygenase.	Hydroxylamine	0-9	linoleate 9S-lipoxygenase-4	Glycine max	124-136
1315759-0	1992	Nitroxide metabolites from alkylhydroxylamines and N-hydroxyurea derivatives resulting from reductive inhibition of soybean lipoxygenase.	alkylhydroxylamines	27-46	linoleate 9S-lipoxygenase-4	Glycine max	124-136
1315759-2	1992	Recent studies have shown that compounds containing the hydroxamate moiety are potent inhibitors of lipoxygenase.	hydroxamate	56-67	linoleate 9S-lipoxygenase-4	Glycine max	100-112
1315759-0	1992	Nitroxide metabolites from alkylhydroxylamines and N-hydroxyurea derivatives resulting from reductive inhibition of soybean lipoxygenase.	Hydroxyurea	51-64	linoleate 9S-lipoxygenase-4	Glycine max	124-136
1315759-5	1992	It is consistently found that the selected NOH-containing compounds, e.g. alkylhydroxylamines or N-hydroxyureas, are also oxidized by lipoxygenase to form their corresponding nitroxides.	2-amino-5-chlorobenzophenone N-hydroxyamidinohydrazone	43-46	linoleate 9S-lipoxygenase-4	Glycine max	134-146
1315759-1	1992	One proposed mechanism of the inactivation of lipoxygenase by inhibitors is the reduction of the catalytically active ferric form of the enzyme to its ferrous form.	Ferric enterobactin ion	118-124	linoleate 9S-lipoxygenase-4	Glycine max	46-58
1315759-5	1992	It is consistently found that the selected NOH-containing compounds, e.g. alkylhydroxylamines or N-hydroxyureas, are also oxidized by lipoxygenase to form their corresponding nitroxides.	alkylhydroxylamines	74-93	linoleate 9S-lipoxygenase-4	Glycine max	134-146
1766441-0	1991	Lipoxygenase gene expression is modulated in plants by water deficit, wounding, and methyl jasmonate.	methyl jasmonate	84-100	linoleate 9S-lipoxygenase-4	Glycine max	0-12
1315759-5	1992	It is consistently found that the selected NOH-containing compounds, e.g. alkylhydroxylamines or N-hydroxyureas, are also oxidized by lipoxygenase to form their corresponding nitroxides.	Hydroxyurea	97-111	linoleate 9S-lipoxygenase-4	Glycine max	134-146
1315759-5	1992	It is consistently found that the selected NOH-containing compounds, e.g. alkylhydroxylamines or N-hydroxyureas, are also oxidized by lipoxygenase to form their corresponding nitroxides.	Hydroxylamine	175-185	linoleate 9S-lipoxygenase-4	Glycine max	134-146
1576704-3	1992	The results demonstrated that both purified soybean lipoxygenase and guinea-pig tissue cytosolic lipoxygenases were able to activate AFB1 to form [3H]AFB1-DNA adduct(s).	Tritium	147-149	linoleate 9S-lipoxygenase-4	Glycine max	52-64
1576704-4	1992	The reaction was completely inhibited by nordihydroguaiaretic acid (NDGA, 0.1 mM), a lipoxygenase inhibitor and an antioxidant, but not by indomethacin (0.1 mM), an inhibitor of prostaglandin H synthase (PHS), indicating that this reaction is associated with lipoxygenase activity, and/or is involved in a peroxyl radical process.	Masoprocol	41-66	linoleate 9S-lipoxygenase-4	Glycine max	85-97
1576704-4	1992	The reaction was completely inhibited by nordihydroguaiaretic acid (NDGA, 0.1 mM), a lipoxygenase inhibitor and an antioxidant, but not by indomethacin (0.1 mM), an inhibitor of prostaglandin H synthase (PHS), indicating that this reaction is associated with lipoxygenase activity, and/or is involved in a peroxyl radical process.	Masoprocol	41-66	linoleate 9S-lipoxygenase-4	Glycine max	259-271
1576704-4	1992	The reaction was completely inhibited by nordihydroguaiaretic acid (NDGA, 0.1 mM), a lipoxygenase inhibitor and an antioxidant, but not by indomethacin (0.1 mM), an inhibitor of prostaglandin H synthase (PHS), indicating that this reaction is associated with lipoxygenase activity, and/or is involved in a peroxyl radical process.	Masoprocol	68-72	linoleate 9S-lipoxygenase-4	Glycine max	85-97
1576704-4	1992	The reaction was completely inhibited by nordihydroguaiaretic acid (NDGA, 0.1 mM), a lipoxygenase inhibitor and an antioxidant, but not by indomethacin (0.1 mM), an inhibitor of prostaglandin H synthase (PHS), indicating that this reaction is associated with lipoxygenase activity, and/or is involved in a peroxyl radical process.	Masoprocol	68-72	linoleate 9S-lipoxygenase-4	Glycine max	259-271
1576704-15	1992	When expressed per gram of tissue, renal and hepatic PHS activities and renal lipoxygenase activities for AFB1 activation were similar, and higher than the activity of pulmonary PHS, while pulmonary PHS activity for the oxidation of N,N,N",N"-tetramethyl-p-phenylenediamine (TMPD) was similar to that in liver and lower than that in kidney.	Aflatoxin B1	106-110	linoleate 9S-lipoxygenase-4	Glycine max	78-90
1312396-0	1992	Isolation and characterization of the initial radical adduct formed from linoleic acid and alpha-(4-pyridyl 1-oxide)-N-tert-butylnitrone in the presence of soybean lipoxygenase.	Linoleic Acid	73-86	linoleate 9S-lipoxygenase-4	Glycine max	164-176
1312396-0	1992	Isolation and characterization of the initial radical adduct formed from linoleic acid and alpha-(4-pyridyl 1-oxide)-N-tert-butylnitrone in the presence of soybean lipoxygenase.	alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone	91-136	linoleate 9S-lipoxygenase-4	Glycine max	164-176
1312396-1	1992	The spin trapping agent alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN) was used to trap the initial radical formed from [U-14C]linoleic acid in the reaction with soybean lipoxygenase.	alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone	24-69	linoleate 9S-lipoxygenase-4	Glycine max	176-188
1312396-1	1992	The spin trapping agent alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN) was used to trap the initial radical formed from [U-14C]linoleic acid in the reaction with soybean lipoxygenase.	alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone	71-75	linoleate 9S-lipoxygenase-4	Glycine max	176-188
1312396-1	1992	The spin trapping agent alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone (POBN) was used to trap the initial radical formed from [U-14C]linoleic acid in the reaction with soybean lipoxygenase.	[u-14c]linoleic acid	126-146	linoleate 9S-lipoxygenase-4	Glycine max	176-188
1312396-8	1992	The trapped linoleoyl radical adduct provides evidence for the production of a free radical as part of the enzymatic mechanism of soybean lipoxygenase.	linoleoyl radical	12-29	linoleate 9S-lipoxygenase-4	Glycine max	138-150
1312396-8	1992	The trapped linoleoyl radical adduct provides evidence for the production of a free radical as part of the enzymatic mechanism of soybean lipoxygenase.	Free Radicals	79-91	linoleate 9S-lipoxygenase-4	Glycine max	138-150
1544449-0	1992	A lipoxygenase is the main lipid body protein in cucumber and soybean cotyledons during the stage of triglyceride mobilization.	Triglycerides	101-113	linoleate 9S-lipoxygenase-4	Glycine max	2-14
16668631-4	1992	Lipoxygenases L-5 and L-6 preferentially produced 13(S)-hydroperoxy-9(Z), 11(E)-octadecadienoic acid (13S-HPOD) as a reaction product of linoleic acid, whereas lipoxygenase L-4 produced both 13S-HPOD and 9(S)-hydroperoxy-10(E), 12(Z)-octadecadienoic acid.	13s-hpod	102-110	linoleate 9S-lipoxygenase-4	Glycine max	160-172
16668631-4	1992	Lipoxygenases L-5 and L-6 preferentially produced 13(S)-hydroperoxy-9(Z), 11(E)-octadecadienoic acid (13S-HPOD) as a reaction product of linoleic acid, whereas lipoxygenase L-4 produced both 13S-HPOD and 9(S)-hydroperoxy-10(E), 12(Z)-octadecadienoic acid.	13s-hpod	102-110	linoleate 9S-lipoxygenase-4	Glycine max	173-176
16668631-4	1992	Lipoxygenases L-5 and L-6 preferentially produced 13(S)-hydroperoxy-9(Z), 11(E)-octadecadienoic acid (13S-HPOD) as a reaction product of linoleic acid, whereas lipoxygenase L-4 produced both 13S-HPOD and 9(S)-hydroperoxy-10(E), 12(Z)-octadecadienoic acid.	Linoleic Acid	137-150	linoleate 9S-lipoxygenase-4	Glycine max	160-172
16668631-4	1992	Lipoxygenases L-5 and L-6 preferentially produced 13(S)-hydroperoxy-9(Z), 11(E)-octadecadienoic acid (13S-HPOD) as a reaction product of linoleic acid, whereas lipoxygenase L-4 produced both 13S-HPOD and 9(S)-hydroperoxy-10(E), 12(Z)-octadecadienoic acid.	Linoleic Acid	137-150	linoleate 9S-lipoxygenase-4	Glycine max	173-176
1766441-1	1991	Two classes of lipoxygenase (LOX) cDNAs, designated loxA and loxB, were isolated from soybean.	loxb	61-65	linoleate 9S-lipoxygenase-4	Glycine max	15-27
1766441-1	1991	Two classes of lipoxygenase (LOX) cDNAs, designated loxA and loxB, were isolated from soybean.	loxb	61-65	linoleate 9S-lipoxygenase-4	Glycine max	29-32
1815499-0	1991	Proline hydroxylation by soybean lipoxygenase.	Proline	0-7	linoleate 9S-lipoxygenase-4	Glycine max	33-45
1815499-1	1991	The lipoxygenase-catalyzed hydroxylation of proline was studied in vitro in the presence of linoleic acid.	Proline	44-51	linoleate 9S-lipoxygenase-4	Glycine max	4-16
1815499-1	1991	The lipoxygenase-catalyzed hydroxylation of proline was studied in vitro in the presence of linoleic acid.	Linoleic Acid	92-105	linoleate 9S-lipoxygenase-4	Glycine max	4-16
1815499-6	1991	It is suggested that free-radical products of linoleic acid peroxidation may co-oxygenate proline in the presence of lipoxygenase.	Linoleic Acid	46-59	linoleate 9S-lipoxygenase-4	Glycine max	117-129
1815499-6	1991	It is suggested that free-radical products of linoleic acid peroxidation may co-oxygenate proline in the presence of lipoxygenase.	Proline	90-97	linoleate 9S-lipoxygenase-4	Glycine max	117-129
1654081-1	1991	Inhibition of soybean lipoxygenase (L-1) and potato 5-lipoxygenase (5-PLO) by the pyrazoline derivatives phenidone and BW755C only occurs after oxidation of these compounds by the peroxidase-like activity of the lipoxygenases.	pyrazoline	82-92	linoleate 9S-lipoxygenase-4	Glycine max	22-34
1931955-0	1991	Keto fatty acids not containing doubly allylic methylenes are lipoxygenase substrates.	keto fatty acids	0-16	linoleate 9S-lipoxygenase-4	Glycine max	62-74
1931955-1	1991	The soybean lipoxygenase I oxygenates the unusual substrate 12-keto-(9Z)-octadecenoic acid methyl ester as indicated by oxygen uptake and spectral changes of the incubation mixture.	12-keto-(9z)-octadecenoic acid methyl ester	60-103	linoleate 9S-lipoxygenase-4	Glycine max	12-24
1931955-4	1991	These data and the earlier results on the oxygenation of furanoic fatty acids (Boyer et al., 1979) indicate that the lipoxygenase reaction is not restricted to substrates containing a 1,4-pentadiene structure.	furanoic fatty acids	57-77	linoleate 9S-lipoxygenase-4	Glycine max	117-129
1931955-4	1991	These data and the earlier results on the oxygenation of furanoic fatty acids (Boyer et al., 1979) indicate that the lipoxygenase reaction is not restricted to substrates containing a 1,4-pentadiene structure.	1,4-PENTADIENE	184-198	linoleate 9S-lipoxygenase-4	Glycine max	117-129
1654081-1	1991	Inhibition of soybean lipoxygenase (L-1) and potato 5-lipoxygenase (5-PLO) by the pyrazoline derivatives phenidone and BW755C only occurs after oxidation of these compounds by the peroxidase-like activity of the lipoxygenases.	phenidone	105-114	linoleate 9S-lipoxygenase-4	Glycine max	22-34
1654081-1	1991	Inhibition of soybean lipoxygenase (L-1) and potato 5-lipoxygenase (5-PLO) by the pyrazoline derivatives phenidone and BW755C only occurs after oxidation of these compounds by the peroxidase-like activity of the lipoxygenases.	4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine	119-125	linoleate 9S-lipoxygenase-4	Glycine max	22-34
1645725-5	1991	1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine next was fragmented by an uncontrolled free radical-catalyzed reaction: it was treated with soybean lipoxygenase to form its sn-2 15-hydroperoxy derivative (which did not activate neutrophils) and then allowed to oxidize under air.	1-O-hexadecyl-2-arachidonyl-sn-glycero-3-phosphocholine	0-54	linoleate 9S-lipoxygenase-4	Glycine max	155-167
1910308-2	1991	Among these compounds, 15(S)-hydroperoxyeicosatetraenoic acid (15(S)-HPETE)2 was found to be the most effective in the inactivation of lipoxygenase.	15(s)-hydroperoxyeicosatetraenoic acid (15(s)-hpete)2	23-76	linoleate 9S-lipoxygenase-4	Glycine max	135-147
1910308-6	1991	Based on these results, it is suggested that the selective inactivation of lipoxygenase by these peroxy acids may be due to unstable intermediates produced from hydroperoxy acids bound to the active site of lipoxygenase.	peroxy acids	97-109	linoleate 9S-lipoxygenase-4	Glycine max	75-87
1910308-6	1991	Based on these results, it is suggested that the selective inactivation of lipoxygenase by these peroxy acids may be due to unstable intermediates produced from hydroperoxy acids bound to the active site of lipoxygenase.	peroxy acids	97-109	linoleate 9S-lipoxygenase-4	Glycine max	207-219
1910308-6	1991	Based on these results, it is suggested that the selective inactivation of lipoxygenase by these peroxy acids may be due to unstable intermediates produced from hydroperoxy acids bound to the active site of lipoxygenase.	hydroperoxy acids	161-178	linoleate 9S-lipoxygenase-4	Glycine max	75-87
1910308-6	1991	Based on these results, it is suggested that the selective inactivation of lipoxygenase by these peroxy acids may be due to unstable intermediates produced from hydroperoxy acids bound to the active site of lipoxygenase.	hydroperoxy acids	161-178	linoleate 9S-lipoxygenase-4	Glycine max	207-219
1680652-1	1991	Catalytic potential of lipoxygenase coupled with linoleic acid oxidation.	Linoleic Acid	49-62	linoleate 9S-lipoxygenase-4	Glycine max	23-35
1680652-7	1991	Lipoxygenase inhibitors nordihydroguaiaretic acid, phenidone, 5,8,11-eicosatriynoic acid, and 5,8,11,14-eicosatetraynoic acid significantly inhibited epoxidation in a dose-dependent manner.	Masoprocol	24-49	linoleate 9S-lipoxygenase-4	Glycine max	0-12
1680652-7	1991	Lipoxygenase inhibitors nordihydroguaiaretic acid, phenidone, 5,8,11-eicosatriynoic acid, and 5,8,11,14-eicosatetraynoic acid significantly inhibited epoxidation in a dose-dependent manner.	phenidone	51-60	linoleate 9S-lipoxygenase-4	Glycine max	0-12
1680652-7	1991	Lipoxygenase inhibitors nordihydroguaiaretic acid, phenidone, 5,8,11-eicosatriynoic acid, and 5,8,11,14-eicosatetraynoic acid significantly inhibited epoxidation in a dose-dependent manner.	5,8,11-eicosatriynoic acid	62-88	linoleate 9S-lipoxygenase-4	Glycine max	0-12
1680652-7	1991	Lipoxygenase inhibitors nordihydroguaiaretic acid, phenidone, 5,8,11-eicosatriynoic acid, and 5,8,11,14-eicosatetraynoic acid significantly inhibited epoxidation in a dose-dependent manner.	5,8,11,14-Eicosatetraynoic Acid	94-125	linoleate 9S-lipoxygenase-4	Glycine max	0-12
1822994-5	1991	Also, a lipoxygenase cDNA coding region was able to detect changes in an mRNA that closely parallel changes in vsp94 protein levels resulting from alteration of nitrogen sinks.	Nitrogen	161-169	linoleate 9S-lipoxygenase-4	Glycine max	8-20
1822994-5	1991	Also, a lipoxygenase cDNA coding region was able to detect changes in an mRNA that closely parallel changes in vsp94 protein levels resulting from alteration of nitrogen sinks.	Nitrogen	161-169	linoleate 9S-lipoxygenase-4	Glycine max	111-116
1645725-5	1991	1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine next was fragmented by an uncontrolled free radical-catalyzed reaction: it was treated with soybean lipoxygenase to form its sn-2 15-hydroperoxy derivative (which did not activate neutrophils) and then allowed to oxidize under air.	Free Radicals	94-106	linoleate 9S-lipoxygenase-4	Glycine max	155-167
1646600-3	1991	Linoleic acid-derived radicals, which are formed in the reaction of linoleic acid with soybean lipoxygenase, were trapped with nitrosobenzene and the resulting radical adducts were analysed by h.p.l.c.-e.p.r.	nitrosobenzene	127-141	linoleate 9S-lipoxygenase-4	Glycine max	95-107
1646600-15	1991	Peak III, which was observed in the reaction mixture without soybean lipoxygenase, corresponds to a linoleic acid radical (L.).	linoleic acid radical	100-121	linoleate 9S-lipoxygenase-4	Glycine max	69-81
1646600-3	1991	Linoleic acid-derived radicals, which are formed in the reaction of linoleic acid with soybean lipoxygenase, were trapped with nitrosobenzene and the resulting radical adducts were analysed by h.p.l.c.-e.p.r.	Linoleic Acid	0-13	linoleate 9S-lipoxygenase-4	Glycine max	95-107
1646600-3	1991	Linoleic acid-derived radicals, which are formed in the reaction of linoleic acid with soybean lipoxygenase, were trapped with nitrosobenzene and the resulting radical adducts were analysed by h.p.l.c.-e.p.r.	Linoleic Acid	68-81	linoleate 9S-lipoxygenase-4	Glycine max	95-107
1646600-16	1991	The 12,13-epoxylinoleic acid radical, 12,13-epoxylinolenic acid radical and 14,15-epoxyarachidonic acid radical were also detected in the reactions of linoleic acid, linolenic acid and arachidonic acid respectively, with soybean lipoxygenase using nitrosobenzene and 2-methyl-2-nitrosopropane as spin-trapping agents.	12,13-epoxylinoleic acid radical	4-36	linoleate 9S-lipoxygenase-4	Glycine max	229-241
1646600-16	1991	The 12,13-epoxylinoleic acid radical, 12,13-epoxylinolenic acid radical and 14,15-epoxyarachidonic acid radical were also detected in the reactions of linoleic acid, linolenic acid and arachidonic acid respectively, with soybean lipoxygenase using nitrosobenzene and 2-methyl-2-nitrosopropane as spin-trapping agents.	14,15-epoxyarachidonic acid radical	76-111	linoleate 9S-lipoxygenase-4	Glycine max	229-241
1646600-16	1991	The 12,13-epoxylinoleic acid radical, 12,13-epoxylinolenic acid radical and 14,15-epoxyarachidonic acid radical were also detected in the reactions of linoleic acid, linolenic acid and arachidonic acid respectively, with soybean lipoxygenase using nitrosobenzene and 2-methyl-2-nitrosopropane as spin-trapping agents.	Arachidonic Acid	87-103	linoleate 9S-lipoxygenase-4	Glycine max	229-241
1646600-16	1991	The 12,13-epoxylinoleic acid radical, 12,13-epoxylinolenic acid radical and 14,15-epoxyarachidonic acid radical were also detected in the reactions of linoleic acid, linolenic acid and arachidonic acid respectively, with soybean lipoxygenase using nitrosobenzene and 2-methyl-2-nitrosopropane as spin-trapping agents.	nitrosobenzene	248-262	linoleate 9S-lipoxygenase-4	Glycine max	229-241
1646600-16	1991	The 12,13-epoxylinoleic acid radical, 12,13-epoxylinolenic acid radical and 14,15-epoxyarachidonic acid radical were also detected in the reactions of linoleic acid, linolenic acid and arachidonic acid respectively, with soybean lipoxygenase using nitrosobenzene and 2-methyl-2-nitrosopropane as spin-trapping agents.	tert-nitrosobutane	267-292	linoleate 9S-lipoxygenase-4	Glycine max	229-241
1903659-0	1991	Soybean lipoxygenase catalysed oxygenation of unsaturated fatty acid encapsulated in cyclodextrin.	Fatty Acids, Unsaturated	46-68	linoleate 9S-lipoxygenase-4	Glycine max	8-20
1850741-2	1991	Using soybean lipoxygenase-1 as a model, we have shown that two classes of lipoxygenase inhibitors currently in development as potential antiinflammatory agents obtain a significant amount of their potency by reducing the lipoxygenase active-site iron from the active ferric state to the inactive ferrous state.	Iron	247-251	linoleate 9S-lipoxygenase-4	Glycine max	14-26
1850741-2	1991	Using soybean lipoxygenase-1 as a model, we have shown that two classes of lipoxygenase inhibitors currently in development as potential antiinflammatory agents obtain a significant amount of their potency by reducing the lipoxygenase active-site iron from the active ferric state to the inactive ferrous state.	Iron	247-251	linoleate 9S-lipoxygenase-4	Glycine max	75-87
1903659-0	1991	Soybean lipoxygenase catalysed oxygenation of unsaturated fatty acid encapsulated in cyclodextrin.	Cyclodextrins	85-97	linoleate 9S-lipoxygenase-4	Glycine max	8-20
1850741-5	1991	This brings to (at least) five the number of classes of lipoxygenase inhibitors that are capable of reducing the active-site ferric ion and suggests the generality of this approach in the rational design of lipoxygenase inhibitors.	Ferric enterobactin ion	125-131	linoleate 9S-lipoxygenase-4	Glycine max	56-68
1903659-1	1991	The linoleic or arachidonic acid entrapped in cyclodextrin (alpha, beta or gamma) serves as an excellent substrate for soybean lipoxygenase-1 catalysis.	Linoleic Acid	4-12	linoleate 9S-lipoxygenase-4	Glycine max	127-139
1850741-5	1991	This brings to (at least) five the number of classes of lipoxygenase inhibitors that are capable of reducing the active-site ferric ion and suggests the generality of this approach in the rational design of lipoxygenase inhibitors.	Ferric enterobactin ion	125-131	linoleate 9S-lipoxygenase-4	Glycine max	207-219
1903659-1	1991	The linoleic or arachidonic acid entrapped in cyclodextrin (alpha, beta or gamma) serves as an excellent substrate for soybean lipoxygenase-1 catalysis.	Arachidonic Acid	16-32	linoleate 9S-lipoxygenase-4	Glycine max	127-139
1903659-1	1991	The linoleic or arachidonic acid entrapped in cyclodextrin (alpha, beta or gamma) serves as an excellent substrate for soybean lipoxygenase-1 catalysis.	Cyclodextrins	46-58	linoleate 9S-lipoxygenase-4	Glycine max	127-139
16668141-6	1991	MeJA was almost as effective in N-deficient plants as in those receiving abundant N. Inhibitors of lipoxygenase, the first enzyme in the jasmonic acid biosynthetic pathway, blocked induction by wounding and petiole girdling but not by MeJA.	jasmonic acid	137-150	linoleate 9S-lipoxygenase-4	Glycine max	99-111
1903070-2	1991	This process has been found to be related to the inhibition of the lipoxygenase activity, measured as hydroperoxide generation and to produce oxodienes as well.	Hydrogen Peroxide	102-115	linoleate 9S-lipoxygenase-4	Glycine max	67-79
1903070-2	1991	This process has been found to be related to the inhibition of the lipoxygenase activity, measured as hydroperoxide generation and to produce oxodienes as well.	oxodienes	142-151	linoleate 9S-lipoxygenase-4	Glycine max	67-79
1903070-4	1991	The inhibition of lipoxygenase activity by these pigments has been found to be competitive with linoleic acid, showing an increase of 4-7-fold of the Km value of linoleic acid in the presence of concentrations of hemin and hemoglobin as low as 0.2 and 0.02 microM, respectively, for the case of platelet lipoxygenase activity.	Linoleic Acid	96-109	linoleate 9S-lipoxygenase-4	Glycine max	18-30
1903070-4	1991	The inhibition of lipoxygenase activity by these pigments has been found to be competitive with linoleic acid, showing an increase of 4-7-fold of the Km value of linoleic acid in the presence of concentrations of hemin and hemoglobin as low as 0.2 and 0.02 microM, respectively, for the case of platelet lipoxygenase activity.	Linoleic Acid	96-109	linoleate 9S-lipoxygenase-4	Glycine max	304-316
1903070-4	1991	The inhibition of lipoxygenase activity by these pigments has been found to be competitive with linoleic acid, showing an increase of 4-7-fold of the Km value of linoleic acid in the presence of concentrations of hemin and hemoglobin as low as 0.2 and 0.02 microM, respectively, for the case of platelet lipoxygenase activity.	Linoleic Acid	162-175	linoleate 9S-lipoxygenase-4	Glycine max	18-30
1903070-4	1991	The inhibition of lipoxygenase activity by these pigments has been found to be competitive with linoleic acid, showing an increase of 4-7-fold of the Km value of linoleic acid in the presence of concentrations of hemin and hemoglobin as low as 0.2 and 0.02 microM, respectively, for the case of platelet lipoxygenase activity.	Linoleic Acid	162-175	linoleate 9S-lipoxygenase-4	Glycine max	304-316
1903070-6	1991	From the quenching of the intrinsic fluorescence of soybean lipoxygenase activity by hemin, we have obtained a dissociation constant of hemin-soybean lipoxygenase of 0.5 microM.	Hemin	85-90	linoleate 9S-lipoxygenase-4	Glycine max	60-72
1903070-6	1991	From the quenching of the intrinsic fluorescence of soybean lipoxygenase activity by hemin, we have obtained a dissociation constant of hemin-soybean lipoxygenase of 0.5 microM.	Hemin	85-90	linoleate 9S-lipoxygenase-4	Glycine max	150-162
1903070-7	1991	The results obtained in this paper for the cooxidation process of hemin and hemoglobin by lipoxygenase can be rationalized in terms of hemin binding at or near to the catalytic center, resulting in a lesser binding of linoleic acid and an enhanced release of radicals, and pigment bleaching by radicals and lipid hydroperoxides.	Hemin	66-71	linoleate 9S-lipoxygenase-4	Glycine max	90-102
1903070-7	1991	The results obtained in this paper for the cooxidation process of hemin and hemoglobin by lipoxygenase can be rationalized in terms of hemin binding at or near to the catalytic center, resulting in a lesser binding of linoleic acid and an enhanced release of radicals, and pigment bleaching by radicals and lipid hydroperoxides.	Linoleic Acid	218-231	linoleate 9S-lipoxygenase-4	Glycine max	90-102
1903070-7	1991	The results obtained in this paper for the cooxidation process of hemin and hemoglobin by lipoxygenase can be rationalized in terms of hemin binding at or near to the catalytic center, resulting in a lesser binding of linoleic acid and an enhanced release of radicals, and pigment bleaching by radicals and lipid hydroperoxides.	Lipid Peroxides	307-327	linoleate 9S-lipoxygenase-4	Glycine max	90-102
1904618-0	1991	Role of lipoxygenase in xenobiotic metabolism: sulfoxidation of thiobenzamide by purified soybean lipoxygenase.	thiobenzamide	64-77	linoleate 9S-lipoxygenase-4	Glycine max	8-20
1904618-0	1991	Role of lipoxygenase in xenobiotic metabolism: sulfoxidation of thiobenzamide by purified soybean lipoxygenase.	thiobenzamide	64-77	linoleate 9S-lipoxygenase-4	Glycine max	98-110
1904618-2	1991	To further explore the spectrum of reactions catalyzed by lipoxygenase, sulfoxidation of thiobenzamide was studied.	thiobenzamide	89-102	linoleate 9S-lipoxygenase-4	Glycine max	58-70
1904618-3	1991	Purified soybean lipoxygenase was found to oxidize thiobenzamide to thiobenzamide sulfoxide in the presence of linoleic acid at a rate of 241 nmoles/min/nmole enzyme.	thiobenzamide	51-64	linoleate 9S-lipoxygenase-4	Glycine max	17-29
1904618-3	1991	Purified soybean lipoxygenase was found to oxidize thiobenzamide to thiobenzamide sulfoxide in the presence of linoleic acid at a rate of 241 nmoles/min/nmole enzyme.	thiobenzamide sulfoxide	68-91	linoleate 9S-lipoxygenase-4	Glycine max	17-29
1904618-3	1991	Purified soybean lipoxygenase was found to oxidize thiobenzamide to thiobenzamide sulfoxide in the presence of linoleic acid at a rate of 241 nmoles/min/nmole enzyme.	Linoleic Acid	111-124	linoleate 9S-lipoxygenase-4	Glycine max	17-29
1904618-6	1991	Nordihydroguaiaretic acid and phenidone, the classical inhibitors of lipoxygenase, significantly blocked the sulfoxidation of thiobenzamide.	Masoprocol	0-25	linoleate 9S-lipoxygenase-4	Glycine max	69-81
1900203-4	1991	The soybean lipoxygenase, in contrast, prefers the 9Z,12Z-octadecadienoic acid (linoleic acid) which is oxygenated to its n - 6 hydroperoxy derivative.	Linoleic Acid	51-78	linoleate 9S-lipoxygenase-4	Glycine max	12-24
1904618-6	1991	Nordihydroguaiaretic acid and phenidone, the classical inhibitors of lipoxygenase, significantly blocked the sulfoxidation of thiobenzamide.	phenidone	30-39	linoleate 9S-lipoxygenase-4	Glycine max	69-81
1900203-4	1991	The soybean lipoxygenase, in contrast, prefers the 9Z,12Z-octadecadienoic acid (linoleic acid) which is oxygenated to its n - 6 hydroperoxy derivative.	Linoleic Acid	80-93	linoleate 9S-lipoxygenase-4	Glycine max	12-24
1904618-6	1991	Nordihydroguaiaretic acid and phenidone, the classical inhibitors of lipoxygenase, significantly blocked the sulfoxidation of thiobenzamide.	thiobenzamide	126-139	linoleate 9S-lipoxygenase-4	Glycine max	69-81
2171436-0	1990	Alkyl free radicals from the beta-scission of fatty acid alkoxyl radicals as detected by spin trapping in a lipoxygenase system.	Free Radicals	6-19	linoleate 9S-lipoxygenase-4	Glycine max	108-120
1900203-8	1991	The soybean lipoxygenase converts the 8Z,11Z,14Z-isomer with a singular positional specificity to the corresponding 15S-hydroperoxy derivatives.	8z,11z,14z	38-48	linoleate 9S-lipoxygenase-4	Glycine max	12-24
1842018-4	1991	The experiments with soybean lipoxygenase showed that the three components of silymarin brought about a concentration-dependent non-competitive inhibition of the lipoxygenase.	Silymarin	78-87	linoleate 9S-lipoxygenase-4	Glycine max	29-41
1842018-4	1991	The experiments with soybean lipoxygenase showed that the three components of silymarin brought about a concentration-dependent non-competitive inhibition of the lipoxygenase.	Silymarin	78-87	linoleate 9S-lipoxygenase-4	Glycine max	162-174
1842018-5	1991	The experiments also showed an analogous interaction with animal lipoxygenase, thus showing that an inhibition of the peroxidation of the fatty acid in vivo was self-evident.	Fatty Acids	138-148	linoleate 9S-lipoxygenase-4	Glycine max	65-77
18597258-0	1990	Polarographic measurement of oxygen uptake using lipoxygenase in reverse micelles.	Oxygen	29-35	linoleate 9S-lipoxygenase-4	Glycine max	49-61
18597258-1	1990	Lipoxygenase-catalyzed linoleic acid peroxidation was chosen as a model system to study the applicability of oxygraphy to monitor the oxygen uptake in organic solvents containing reverse micelles.	Linoleic Acid	23-36	linoleate 9S-lipoxygenase-4	Glycine max	0-12
2171436-0	1990	Alkyl free radicals from the beta-scission of fatty acid alkoxyl radicals as detected by spin trapping in a lipoxygenase system.	fatty acid alkoxyl radicals	46-73	linoleate 9S-lipoxygenase-4	Glycine max	108-120
2171436-1	1990	2-Methyl-2-nitrosopropane (tNB)-radical adducts from incubation mixtures of fatty acids and soybean lipoxygenase in borate buffer (pH 9.0) were measured by electron paramagnetic resonance (EPR).	tert-nitrosobutane	0-25	linoleate 9S-lipoxygenase-4	Glycine max	100-112
2171436-1	1990	2-Methyl-2-nitrosopropane (tNB)-radical adducts from incubation mixtures of fatty acids and soybean lipoxygenase in borate buffer (pH 9.0) were measured by electron paramagnetic resonance (EPR).	Trinitrobenzenesulfonic Acid	27-30	linoleate 9S-lipoxygenase-4	Glycine max	100-112
2171436-1	1990	2-Methyl-2-nitrosopropane (tNB)-radical adducts from incubation mixtures of fatty acids and soybean lipoxygenase in borate buffer (pH 9.0) were measured by electron paramagnetic resonance (EPR).	Borates	116-122	linoleate 9S-lipoxygenase-4	Glycine max	100-112
2171436-4	1990	EPR spectra of tNB-radical adducts formed in mixtures of either linoleic acid, arachidonic acid, or 15-hydroperoxyeicosatetraenoic acid with lipoxygenase exhibited hyperfine structure characteristic of tNB/.CH2CH2-R with hyperfine coupling constants: aN = 17.1 G; aH beta = 11.2 G (2H); and aH gamma = 0.6 G (2H).	Trinitrobenzenesulfonic Acid	15-18	linoleate 9S-lipoxygenase-4	Glycine max	141-153
2171436-4	1990	EPR spectra of tNB-radical adducts formed in mixtures of either linoleic acid, arachidonic acid, or 15-hydroperoxyeicosatetraenoic acid with lipoxygenase exhibited hyperfine structure characteristic of tNB/.CH2CH2-R with hyperfine coupling constants: aN = 17.1 G; aH beta = 11.2 G (2H); and aH gamma = 0.6 G (2H).	15-hydroperoxyeicosatetraenoic acid	100-135	linoleate 9S-lipoxygenase-4	Glycine max	141-153
2171436-4	1990	EPR spectra of tNB-radical adducts formed in mixtures of either linoleic acid, arachidonic acid, or 15-hydroperoxyeicosatetraenoic acid with lipoxygenase exhibited hyperfine structure characteristic of tNB/.CH2CH2-R with hyperfine coupling constants: aN = 17.1 G; aH beta = 11.2 G (2H); and aH gamma = 0.6 G (2H).	Trinitrobenzenesulfonic Acid	202-205	linoleate 9S-lipoxygenase-4	Glycine max	141-153
2171436-4	1990	EPR spectra of tNB-radical adducts formed in mixtures of either linoleic acid, arachidonic acid, or 15-hydroperoxyeicosatetraenoic acid with lipoxygenase exhibited hyperfine structure characteristic of tNB/.CH2CH2-R with hyperfine coupling constants: aN = 17.1 G; aH beta = 11.2 G (2H); and aH gamma = 0.6 G (2H).	r	2-3	linoleate 9S-lipoxygenase-4	Glycine max	141-153
2171436-4	1990	EPR spectra of tNB-radical adducts formed in mixtures of either linoleic acid, arachidonic acid, or 15-hydroperoxyeicosatetraenoic acid with lipoxygenase exhibited hyperfine structure characteristic of tNB/.CH2CH2-R with hyperfine coupling constants: aN = 17.1 G; aH beta = 11.2 G (2H); and aH gamma = 0.6 G (2H).	Deuterium	282-284	linoleate 9S-lipoxygenase-4	Glycine max	141-153
2171436-4	1990	EPR spectra of tNB-radical adducts formed in mixtures of either linoleic acid, arachidonic acid, or 15-hydroperoxyeicosatetraenoic acid with lipoxygenase exhibited hyperfine structure characteristic of tNB/.CH2CH2-R with hyperfine coupling constants: aN = 17.1 G; aH beta = 11.2 G (2H); and aH gamma = 0.6 G (2H).	Deuterium	309-311	linoleate 9S-lipoxygenase-4	Glycine max	141-153
2118902-3	1990	The dual specificity considered here is typified by the oxygenation of arachidonic acid by the reticulocyte lipoxygenase: two chiral products are formed (12S- and 15S-hydroperoxides, ratio approximately 1:9) via hydrogen abstraction from two separate methylene groups (C-10 and C-13).	Arachidonic Acid	71-87	linoleate 9S-lipoxygenase-4	Glycine max	108-120
2118902-3	1990	The dual specificity considered here is typified by the oxygenation of arachidonic acid by the reticulocyte lipoxygenase: two chiral products are formed (12S- and 15S-hydroperoxides, ratio approximately 1:9) via hydrogen abstraction from two separate methylene groups (C-10 and C-13).	CHEMBL2326358	154-157	linoleate 9S-lipoxygenase-4	Glycine max	108-120
2118902-3	1990	The dual specificity considered here is typified by the oxygenation of arachidonic acid by the reticulocyte lipoxygenase: two chiral products are formed (12S- and 15S-hydroperoxides, ratio approximately 1:9) via hydrogen abstraction from two separate methylene groups (C-10 and C-13).	Carbon	278-279	linoleate 9S-lipoxygenase-4	Glycine max	108-120
2118902-3	1990	The dual specificity considered here is typified by the oxygenation of arachidonic acid by the reticulocyte lipoxygenase: two chiral products are formed (12S- and 15S-hydroperoxides, ratio approximately 1:9) via hydrogen abstraction from two separate methylene groups (C-10 and C-13).	Hydrogen Peroxide	167-181	linoleate 9S-lipoxygenase-4	Glycine max	108-120
2118902-3	1990	The dual specificity considered here is typified by the oxygenation of arachidonic acid by the reticulocyte lipoxygenase: two chiral products are formed (12S- and 15S-hydroperoxides, ratio approximately 1:9) via hydrogen abstraction from two separate methylene groups (C-10 and C-13).	Hydrogen	212-220	linoleate 9S-lipoxygenase-4	Glycine max	108-120
2118902-3	1990	The dual specificity considered here is typified by the oxygenation of arachidonic acid by the reticulocyte lipoxygenase: two chiral products are formed (12S- and 15S-hydroperoxides, ratio approximately 1:9) via hydrogen abstraction from two separate methylene groups (C-10 and C-13).	Carbon	269-270	linoleate 9S-lipoxygenase-4	Glycine max	108-120
2164931-0	1990	The initial characterization of the iron environment in lipoxygenase by Mossbauer spectroscopy.	Iron	36-40	linoleate 9S-lipoxygenase-4	Glycine max	56-68
2164931-1	1990	The incorporation of 57Fe into two lipoxygenase isoenzymes from soybeans has been achieved making possible the first observations of the iron environment in these proteins using Mossbauer spectroscopy.	Iron-57	21-25	linoleate 9S-lipoxygenase-4	Glycine max	35-47
2164931-1	1990	The incorporation of 57Fe into two lipoxygenase isoenzymes from soybeans has been achieved making possible the first observations of the iron environment in these proteins using Mossbauer spectroscopy.	Iron	137-141	linoleate 9S-lipoxygenase-4	Glycine max	35-47
2164931-5	1990	Based on the sign of the electric field gradient, the most likely ligand sphere for the iron in native lipoxygenase consists of oxygen and nitrogen ligands in a roughly octahedral field of symmetry.	Iron	88-92	linoleate 9S-lipoxygenase-4	Glycine max	103-115
2164931-5	1990	Based on the sign of the electric field gradient, the most likely ligand sphere for the iron in native lipoxygenase consists of oxygen and nitrogen ligands in a roughly octahedral field of symmetry.	Nitrogen	139-147	linoleate 9S-lipoxygenase-4	Glycine max	103-115
2164931-9	1990	The Mossbauer spectra (4.2-250 K) for samples of both isoenzymes after oxidation of the iron in native enzyme by the product of lipoxygenase catalysis were extremely broad (20 mm/s) with no obvious narrow resonance lines.	Iron	88-92	linoleate 9S-lipoxygenase-4	Glycine max	128-140
2164931-11	1990	A small molecule containing an iron site sharing many of these Mossbauer and electron paramagnetic resonance properties with lipoxygenase was identified: Fe(II)/(III).diethylenetriaminepentaacetic acid.	Iron	31-35	linoleate 9S-lipoxygenase-4	Glycine max	125-137
2164931-11	1990	A small molecule containing an iron site sharing many of these Mossbauer and electron paramagnetic resonance properties with lipoxygenase was identified: Fe(II)/(III).diethylenetriaminepentaacetic acid.	ammonium ferrous sulfate	154-160	linoleate 9S-lipoxygenase-4	Glycine max	125-137
2164931-11	1990	A small molecule containing an iron site sharing many of these Mossbauer and electron paramagnetic resonance properties with lipoxygenase was identified: Fe(II)/(III).diethylenetriaminepentaacetic acid.	Pentetic Acid	167-201	linoleate 9S-lipoxygenase-4	Glycine max	125-137
33793947-0	2021	Lipoxygenase functions in 1O2 production during root responses to osmotic stress.	CHEBI:63768	26-29	linoleate 9S-lipoxygenase-4	Glycine max	0-12
34919703-0	2022	Oxylipin signaling in salt-stressed soybean is modulated by ligand-dependent interaction of Class II acyl-CoA-binding proteins with lipoxygenase.	Oxylipins	0-8	linoleate 9S-lipoxygenase-4	Glycine max	132-144
34453501-4	2021	The synthetic compounds inhibit lipoxygenase enzyme by competitive mechanism like the prenyloxy coumarins.	5-hydroxy-6-methoxy-7-(3-methyl-but-2-enyloxy)-2H-1-benzopyran-2-one	86-105	linoleate 9S-lipoxygenase-4	Glycine max	32-44
34427748-0	2021	Quantitative proteomic and lipidomics analyses of high oil content GmDGAT1-2 transgenic soybean illustrate the regulatory mechanism of lipoxygenase and oleosin.	Oils	55-58	linoleate 9S-lipoxygenase-4	Glycine max	135-147
34427748-10	2021	Four lipoxygenase proteins were down-regulated in linoleic acid metabolism while four oleosin proteins were up-regulated in the final oil formation.	Linoleic Acid	50-63	linoleate 9S-lipoxygenase-4	Glycine max	5-17
34641543-5	2021	The 3"-fluoro-substituted coumarins 3e and 4e, along with 3-(4-acetyloxyphenyl)-6,8-dibromo-4-methyl-chromen-2-one (3k), were the most potent lipoxygenase (LOX) inhibitors (IC50 11.4, 4.1, and 8.7 muM, respectively) while displaying remarkable hydroxyl radical scavenging ability, 85.2%, 100%, and 92.9%, respectively.	3"-fluoro-substituted	4-25	linoleate 9S-lipoxygenase-4	Glycine max	142-154
34641543-5	2021	The 3"-fluoro-substituted coumarins 3e and 4e, along with 3-(4-acetyloxyphenyl)-6,8-dibromo-4-methyl-chromen-2-one (3k), were the most potent lipoxygenase (LOX) inhibitors (IC50 11.4, 4.1, and 8.7 muM, respectively) while displaying remarkable hydroxyl radical scavenging ability, 85.2%, 100%, and 92.9%, respectively.	3"-fluoro-substituted	4-25	linoleate 9S-lipoxygenase-4	Glycine max	156-159
34641543-5	2021	The 3"-fluoro-substituted coumarins 3e and 4e, along with 3-(4-acetyloxyphenyl)-6,8-dibromo-4-methyl-chromen-2-one (3k), were the most potent lipoxygenase (LOX) inhibitors (IC50 11.4, 4.1, and 8.7 muM, respectively) while displaying remarkable hydroxyl radical scavenging ability, 85.2%, 100%, and 92.9%, respectively.	Coumarins	26-35	linoleate 9S-lipoxygenase-4	Glycine max	142-154
34641543-5	2021	The 3"-fluoro-substituted coumarins 3e and 4e, along with 3-(4-acetyloxyphenyl)-6,8-dibromo-4-methyl-chromen-2-one (3k), were the most potent lipoxygenase (LOX) inhibitors (IC50 11.4, 4.1, and 8.7 muM, respectively) while displaying remarkable hydroxyl radical scavenging ability, 85.2%, 100%, and 92.9%, respectively.	-acetyloxyphenyl)-6,8-dibromo-4-methyl-chromen-2	62-110	linoleate 9S-lipoxygenase-4	Glycine max	142-154
34641543-5	2021	The 3"-fluoro-substituted coumarins 3e and 4e, along with 3-(4-acetyloxyphenyl)-6,8-dibromo-4-methyl-chromen-2-one (3k), were the most potent lipoxygenase (LOX) inhibitors (IC50 11.4, 4.1, and 8.7 muM, respectively) while displaying remarkable hydroxyl radical scavenging ability, 85.2%, 100%, and 92.9%, respectively.	-acetyloxyphenyl)-6,8-dibromo-4-methyl-chromen-2	62-110	linoleate 9S-lipoxygenase-4	Glycine max	156-159
34403937-0	2021	Identification of phenylcarbamoylazinane-1,3,4-oxadiazole amides as lipoxygenase inhibitors with expression analysis and in silico studies.	phenylcarbamoylazinane-1,3,4-oxadiazole amides	18-64	linoleate 9S-lipoxygenase-4	Glycine max	68-80
34571971-0	2021	Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites N-13-Hydroxy-octodecadienoyl-ethanolamine and 13-Hydroxy-octodecadienoyl-glycerol by Human Neutrophils and Eosinophils.	n-13-hydroxy-octodecadienoyl-ethanolamine	65-106	linoleate 9S-lipoxygenase-4	Glycine max	40-52
34571971-0	2021	Biosynthesis of the Novel Endogenous 15-Lipoxygenase Metabolites N-13-Hydroxy-octodecadienoyl-ethanolamine and 13-Hydroxy-octodecadienoyl-glycerol by Human Neutrophils and Eosinophils.	13-hydroxy-octodecadienoyl-glycerol	111-146	linoleate 9S-lipoxygenase-4	Glycine max	40-52
34571971-8	2021	N-13-hydroxy-octodecadienoyl-ethanolamine (13-HODE-EA) and 13-hydroxy-octodecadienoyl-glycerol (13-HODE-G), the 15-lipoxygenase metabolites of LEA and 1-LG, were synthesized using Novozym 435 and soybean lipoxygenase.	n-13-hydroxy-octodecadienoyl-ethanolamine	0-41	linoleate 9S-lipoxygenase-4	Glycine max	204-216
34571971-8	2021	N-13-hydroxy-octodecadienoyl-ethanolamine (13-HODE-EA) and 13-hydroxy-octodecadienoyl-glycerol (13-HODE-G), the 15-lipoxygenase metabolites of LEA and 1-LG, were synthesized using Novozym 435 and soybean lipoxygenase.	Triethylene glycol monododecyl ether	143-146	linoleate 9S-lipoxygenase-4	Glycine max	204-216
34571971-8	2021	N-13-hydroxy-octodecadienoyl-ethanolamine (13-HODE-EA) and 13-hydroxy-octodecadienoyl-glycerol (13-HODE-G), the 15-lipoxygenase metabolites of LEA and 1-LG, were synthesized using Novozym 435 and soybean lipoxygenase.	1-Linoleoyl-(2S)-glycerol	151-155	linoleate 9S-lipoxygenase-4	Glycine max	204-216
34571971-15	2021	In conclusion, our data show that human eosinophils and neutrophils metabolize 1-LG and LEA into the novel endogenous 15-lipoxygenase metabolites 13-HODE-G and 13-HODE-EA.	1-Linoleoyl-(2S)-glycerol	79-83	linoleate 9S-lipoxygenase-4	Glycine max	121-133
34571971-15	2021	In conclusion, our data show that human eosinophils and neutrophils metabolize 1-LG and LEA into the novel endogenous 15-lipoxygenase metabolites 13-HODE-G and 13-HODE-EA.	Triethylene glycol monododecyl ether	88-91	linoleate 9S-lipoxygenase-4	Glycine max	121-133
34571971-15	2021	In conclusion, our data show that human eosinophils and neutrophils metabolize 1-LG and LEA into the novel endogenous 15-lipoxygenase metabolites 13-HODE-G and 13-HODE-EA.	13-hode-g	146-155	linoleate 9S-lipoxygenase-4	Glycine max	121-133
34066803-0	2021	Exploring the 2"-Hydroxy-Chalcone Framework for the Development of Dual Antioxidant and Soybean Lipoxygenase Inhibitory Agents.	2'-hydroxychalcone	14-33	linoleate 9S-lipoxygenase-4	Glycine max	96-108
34066803-2	2021	In an effort to delineate the structural features that favor antioxidant and lipoxygenase (LOX) inhibitory activity, the design, synthesis, and bioactivity profile of a series of 2"-hydroxy-chalcones bearing diverse substituents on rings A and B, are presented.	2'-hydroxychalcone	179-199	linoleate 9S-lipoxygenase-4	Glycine max	77-89
34066803-2	2021	In an effort to delineate the structural features that favor antioxidant and lipoxygenase (LOX) inhibitory activity, the design, synthesis, and bioactivity profile of a series of 2"-hydroxy-chalcones bearing diverse substituents on rings A and B, are presented.	2'-hydroxychalcone	179-199	linoleate 9S-lipoxygenase-4	Glycine max	91-94
34066803-3	2021	Among all the synthesized derivatives, chalcone 4b, bearing two hydroxyl substituents on ring B, was found to possess the best combined activity (82.4% DPPH radical scavenging ability, 82.3% inhibition of lipid peroxidation, and satisfactory LOX inhibition value (IC50 = 70 muM).	Chalcone	39-47	linoleate 9S-lipoxygenase-4	Glycine max	242-245
34066803-4	2021	Chalcone 3c, possessing a methoxymethylene substituent on ring A, and three methoxy groups on ring B, exhibited the most promising LOX inhibitory activity (IC50 = 45 muM).	Chalcone	0-8	linoleate 9S-lipoxygenase-4	Glycine max	131-134